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<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GWL7</accession>
    <name>A0A6P8GWL7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein OZF-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Zinc finger protein OZF-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC116286314</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031548648.1">
        <property type="nucleotide sequence ID" value="XM_031692788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031548649.1">
        <property type="nucleotide sequence ID" value="XM_031692789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286314"/>
    <dbReference type="KEGG" id="aten:116286314"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000839">
        <property type="entry name" value="Zinc finger protein 691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044652992" evidence="11">
        <location>
            <begin position="26"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031548648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031548649.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="59666" checksum="095CA72B93AA0962" modified="2020-12-02" version="1">MSWMLSFFSFEYFVIFVDFPAQTNCFLVNWYVRISMASGDHIKREEMNLDETESDWFGYACDSGEILFYYNIKTGELRWPTNSPHSKNTILKVQTSDVPGVRNELCSVATQTEDYGCVNHCTSMYVDNERQVENRESESLEIKEEVSDDVTIDVSEQNTFNNTDVNENLDEVSEDYGMDESLSTIITKMKEKEIVQNVQPQHKSNTKTYDCSYCGRTFKRKGCLDLHIRTHTGEKPYGCSYCNKTFTNKSNLNVHFRVHTGEKPYECSYCDKAFAARASWRTHLRTHNVEKPYECSYCDMAFAQKVTFNGHLRIHTGNEPYKCWFCNKAFTMKANLNIHLRTHTGEKPYGCSYCDKAFADXSNLRVHLRIHTGEKPFKCSHCDMAFAARASFRAHIRTHTVEEPCKCSYCDMTFAQKGTFDGHLRLNTGVKPYVCWYCNKAFTIKTKLDTHLRTHTGEKPYGCSYCDKAFADKSNLKVHLRVHTGEKPFECSYCDKAFAARASFRAHLRTHTDEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1R5</accession>
    <name>A0A6P8H1R5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inactive rhomboid protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549583.1">
        <property type="nucleotide sequence ID" value="XM_031693723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1R5"/>
    <dbReference type="GeneID" id="116287109"/>
    <dbReference type="KEGG" id="aten:116287109"/>
    <dbReference type="InParanoid" id="A0A6P8H1R5"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="249"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549583.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49238" checksum="17529C96C32C2F91" modified="2020-12-02" version="1">MTSQIRPTAPSSNTRGLVVPAAGSDYKHWPVFTCAYGLVQISMMIWVCNRGGKISNALQPIRRSRLETLTFRGPTVINHTEYPNPWYGPSERSLVQLGALFPPCMRTEHRYNYQFATSWSNIQLRLGREKLGCCEAETLNIAGTLTKKQCQSMSAPNMTQWKEIRCSQRRTGQNFIAHAIRPCCDALASKCHMTSPDHCVFIGGVYHLHAEHCYQVDCLAFSCDADPEVRGIDDDHLLSAGVILPPSYHQWWRFLVTIYLPHGIVDGTILNLLGLPICLIIERKIGLLRMVLVHTTAGVGGHLIGSLCSESTSITTGGVPSLAGIIVISIIYSFRAQTQSSRILLYLSGYFFSLVVLFILSSFPLVNNFSTFSGLILGIFLGFTYLPNLKLRREHVVRVTCLAVIILVFIICLFIFYEVQPSCSWCMKFSCVFFVDGWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2J4</accession>
    <name>A0A6P8H2J4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotubularin-related protein 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549636.1">
        <property type="nucleotide sequence ID" value="XM_031693776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2J4"/>
    <dbReference type="FunCoup" id="A0A6P8H2J4">
        <property type="interactions" value="1466"/>
    </dbReference>
    <dbReference type="GeneID" id="116287138"/>
    <dbReference type="KEGG" id="aten:116287138"/>
    <dbReference type="InParanoid" id="A0A6P8H2J4"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106018">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13211">
        <property type="entry name" value="PH-GRAM_MTMR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF73">
        <property type="entry name" value="LD06050P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="3">
        <location>
            <begin position="125"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549636.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="62549" checksum="8774658D9E783126" modified="2020-12-02" version="1">MEFVEYIKSPRIEKVLLKRRHGTKVEGTLCVTGHHLIFSSRTQHEEELFLLHSAVESIEKKILSGEQAILTICCKNFDLVKLEFSNTEEALNVASSIEDLSVIDDSSLKYPFFYRHLQSLSEEDGWDMFSTDIEFSMMCTSTQNWRISHVNRDYKTCPSYPSSVIVPATVTDEDIKASAQFRQGGRFPVLSYFHKPTGVAVLRSGQPVLGLGNRRCKDDEKLINAALKEKKKGIIVDTRSQAATINSRSKGGGIEPESNYPQWKRVNHNIEKYSALNDSIAKLVEGALDHHLSMNSWLSKLESSGWLDHVQAVLSSAHFVATCVDKQGVPVLVHGDAGYDATLQVTSLVQVILEPNCRTVKGFQGLIDREWLRAGYPFATRCIKVGVSPIRYKGQGPCFLLFLECVWQIYQQFPCSFQFNDKFLQFLYQHSYYSQFGTFLCNNEFERAAIKLKKKTISLWSFINQREVIAPMLNSMYEMNVSAIWPSVSSQSLSLWSGLFLKWQKSHRNGDFFWEEVRRIQNNNKELKHKAVSLRKEFAQLQASLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2W4</accession>
    <name>A0A6P8H2W4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19 20">DELTA-actitoxin-Aeq1c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19 20" type="primary">LOC116288142</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18 19 20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Octamer or nonamer in membranes. Monomer in the soluble state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nematocyst</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actinoporin family. Sea anemone subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550743.1">
        <property type="nucleotide sequence ID" value="XM_031694883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550744.1">
        <property type="nucleotide sequence ID" value="XM_031694884.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550745.1">
        <property type="nucleotide sequence ID" value="XM_031694885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2W4"/>
    <dbReference type="GeneID" id="116288142"/>
    <dbReference type="KEGG" id="aten:116288142"/>
    <dbReference type="OrthoDB" id="5954752at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042151">
        <property type="term" value="C:nematocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051715">
        <property type="term" value="P:cytolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046931">
        <property type="term" value="P:pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.270.20:FF:000001">
        <property type="entry name" value="DELTA-actitoxin-Afr1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050677">
        <property type="entry name" value="Actinoporin_PFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009104">
        <property type="entry name" value="Anemon_actinoporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40388">
        <property type="entry name" value="BRYOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40388:SF1">
        <property type="entry name" value="BRYOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06369">
        <property type="entry name" value="Anemone_cytotox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0166">Nematocyst</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="13" id="KW-1053">Target membrane</keyword>
    <keyword evidence="8" id="KW-0800">Toxin</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653002" evidence="16">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031550743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031550744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031550745.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23850" checksum="AD94F64D88FDE7E0" modified="2020-12-02" version="1">MSRLIIVFIVVTMICAATALSTKRRINKEEKEEKRVVAVAGAIIKGATLTFNVLQTVLKALGDISRKIAVGVDNESGMTWTATNTYFRSGTSDIVLPYKVPHGKALLYNGQKDRGPVATGVVGVLAYAMSDGNTLAVLFSVPYDYNWYSNWGNVRIFKGRRRADQRMYEQLYYYLSPFRGDNGWHERHLGYGLKSRGFMNSGGQAILEIHVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3B5</accession>
    <name>A0A6P8H3B5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287405</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549941.1">
        <property type="nucleotide sequence ID" value="XM_031694081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3B5"/>
    <dbReference type="GeneID" id="116287405"/>
    <dbReference type="KEGG" id="aten:116287405"/>
    <dbReference type="InParanoid" id="A0A6P8H3B5"/>
    <dbReference type="OrthoDB" id="5982648at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549941.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51457" checksum="C85FCA8BC49FF459" modified="2020-12-02" version="1">MSESMEVLNSFDNFVFLAFLLQLLYFANGKEILTIFRNPGNGGLWTDLDQFKLPDSKCSSSNTYCTNWKALPLDSQPCHCECSDFKKATFGFYLGSWTCLDNTEVRKQTECKYKFESEVIGYPLRIVEQDQSYNLILLSRRCSVESKTTRYFTCDGSWATIDSNSWFTITQEDKLKRPTRYRYKLTIGSDVDDVLQGRIISLNINCTKRETSCLLFKLEGTIDCAENVTFATTAKPSSPTRIASDKIPITATATATVSAVPNATAIPNESGKKEKSKASGGSSTVVGIVVTLMIILVIAILIVVYVYLKRKRGEAVWLVDYISSRRVRKTKSTQAKKKTVDEDPVYAEIPEEQRNMNAPVDQAGGIYSYAFDDPQTAYIAPQPAPYNRLEHKQQGLNQEGALYSTADDGPVYNFLERPLAENNIIMAPENTVNEGPPSQVLEPEYLVLEEPDTTSVNTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6U0</accession>
    <name>A0A6P8H6U0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116288533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031551201.1">
        <property type="nucleotide sequence ID" value="XM_031695341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6U0"/>
    <dbReference type="FunCoup" id="A0A6P8H6U0">
        <property type="interactions" value="1090"/>
    </dbReference>
    <dbReference type="GeneID" id="116288533"/>
    <dbReference type="KEGG" id="aten:116288533"/>
    <dbReference type="InParanoid" id="A0A6P8H6U0"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="44"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031551201.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20028" checksum="B1242116D7601D04" modified="2020-12-02" version="1">MASQGNISDQDKAMEHVKGLIRCFQDFPKPGISFKDICPILKDPCTLKTVTDVTSDHIRKNVGQIDAIIGLEARGFLFGPQIAMNLGIAFIPIRKSGKLPGPTIKVSYSKEYGEDVFEMQEDALKPGQKVVVFDDLIATGGTLVAACDLVKSAGCEVKQCIALLELEELNGKAKLSVPCHVLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H721</accession>
    <name>A0A6P8H721_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylinositol phosphatase PTPRQ-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551138.1">
        <property type="nucleotide sequence ID" value="XM_031695278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288481"/>
    <dbReference type="KEGG" id="aten:116288481"/>
    <dbReference type="InParanoid" id="A0A6P8H721"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="167"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="257"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="356"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551138.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="69049" checksum="FBD0F35A5251C151" modified="2020-12-02" version="1">MFVALGCPEQSLVGKEINLNLSDSSYTASSYYKKPGISEDVRYKPHNAILYGRYGWASSDNDNPDDYLQIDLGTPRVVTAVATQGSGRTANRECVTKYKLYLATNNITLWHTYKDEFGNXKFFKGNTDSNSVVRHDLTNPQLARYIRFVPVEYHNHKTMRVNVYVTNQEPPRMKFVPNKRSIILTWTYEKCSPTDXITGYLVKVGNTTHKVIGDYQSYTVTSLKPYTEYNVSIKAIKQVGYGVWSNVTTIRTAIAEPESXPSLNATTTSSETSLLKWNLQXSEFIHGPLKGYRITYTPQGGKSNIIIDVGDVGNYTLMYLLXYTTYVITIAVNNTKYIGSPSTERRVRTLEDAPSAPVNITGTLIPAQGSFGPRVVITWDRPREPNGIIRKYTIVYYYNQATSNNKTVIINGTSDLQYTMNITGNGTFSYKISATTIKEGPYKSGDNITILSLVKSRRNADENSTSPFNRSMIAGFVAGFIVLVLILIVVITLYKRRNRNRKNKHEVIVMDPVPVPLAVIDDTPVPENNDYDDLLEVSAKSSFDAENNIGDHTYDEAESSIPDLIMIPAQSPIEFIPPDKSKLTEEFKVCLCQLYVNVTPSYLLSFINVLYILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7J4</accession>
    <name>A0A6P8H7J4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-catenin-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116289572</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552379.1">
        <property type="nucleotide sequence ID" value="XM_031696519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7J4"/>
    <dbReference type="FunCoup" id="A0A6P8H7J4">
        <property type="interactions" value="3129"/>
    </dbReference>
    <dbReference type="GeneID" id="116289572"/>
    <dbReference type="KEGG" id="aten:116289572"/>
    <dbReference type="InParanoid" id="A0A6P8H7J4"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="11">
        <location>
            <begin position="85"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031552379.1"/>
        </source>
    </evidence>
    <sequence length="591" mass="67882" checksum="70CF26C05309D0E3" modified="2020-12-02" version="1">MFFILYNELKLAACLSACLFVLSVCLSVCLFVCLSVCLFCCVLIYLQPDKGTKRKKGDEEDEQISWKKKISEVEAQFMAKGTELTDEERERILEMVDNEPEVETLDVSSLKRMLLSFEKRVTKNQEMRIKYPDLPEKFMESELDLNDEIQKLHIIATAPELYHHIVELNAVNTMLGLLSHENTDIAVNVIDLLQEMTDVDTLNESEEGATALIDALLEGQVIALLVQNLERLEETVKEESDGVYNSLSIIENMTELRDTICQIAGEQGLIGWIIRRLKQKPAFNANKLYSSEILSILLQNTEENRQLLGESNGIDTLLQSLSLYKRYDPTASDELEYMENLFNCLCSALMYNPNKDLFLKGEGLQLMILMLREKKMSRRSALKVLDYAMQGLEGIENCQKFIEFLGLRCLFPLFMKPPKSNKKTGVSEEQFEEHTLSILASLFRNLSGNLRNRLVQKFVEGDHIKIDRLMELHFKYYKKVHDCDEKIEREKEKLVEEGEEIDEETEDMFYLKRLDAGLFTLQLIDCVMLEACCSGVPSIKQRVLALLNQHGGSMKDIKAVMREYAASVGDARSKESREIEKKRLLSLVDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7L8</accession>
    <name>A0A6P8H7L8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Microtubule-associated protein RP/EB family member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116288783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551476.1">
        <property type="nucleotide sequence ID" value="XM_031695616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7L8"/>
    <dbReference type="FunCoup" id="A0A6P8H7L8">
        <property type="interactions" value="1305"/>
    </dbReference>
    <dbReference type="GeneID" id="116288783"/>
    <dbReference type="KEGG" id="aten:116288783"/>
    <dbReference type="InParanoid" id="A0A6P8H7L8"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000007">
        <property type="entry name" value="Microtubule-associated protein, RP/EB family, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="190"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551476.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30816" checksum="C09822E658C12D2B" modified="2020-12-02" version="1">MAVNVFASSQTTDNLSRHELMQWVNDSLQLQYQKVEQMCTGAAYCQFMDMLFENCVNLKKVKFGAKQEHDYINNFKQLQLAFKKSAVDKVIPVDKLVKGRFQDNFEFLQWFKKFFDANYGGQEYDPVAARHGQTDVEVNVIKRKPVGGSGGNIAAQSYQSTTKKTSRTGISKATPSVKAAPLSSAGGGGNSSQKDAKIRELTEELDEMKTTVEGLEKERDFYFGKLRDIEVFCQEGSDVYGPEKETIKKVLAVLYATEDGFAPPEGEQEEQEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9N1</accession>
    <name>A0A6P8H9N1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116289445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552246.1">
        <property type="nucleotide sequence ID" value="XM_031696386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9N1"/>
    <dbReference type="FunCoup" id="A0A6P8H9N1">
        <property type="interactions" value="1737"/>
    </dbReference>
    <dbReference type="GeneID" id="116289445"/>
    <dbReference type="KEGG" id="aten:116289445"/>
    <dbReference type="InParanoid" id="A0A6P8H9N1"/>
    <dbReference type="OrthoDB" id="200206at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000133">
        <property type="entry name" value="Serine-threonine kinase receptor-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552246.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35421" checksum="FFEB2F3A0D4F6996" modified="2020-12-02" version="1">MARQIPLSCSGHTRPVVDLSFSENTPYGYFLISACKDGKPMLRQGDTGDWIGTFEGHKGAVWSASLNKDATKAASGAADFTAKIWDAVTGDELASLPHKHIVKTVDFSSDSNYLLTGSQEKLIRTFDCQNTDADPEVLKGHTGNIRVARWNKDSSCIFSGGEDKVLRVWDIRALENTKNVELQHAITSMELSADGNILLLTYGKTVSFWNAHSMDLIKSFDTPTQVFSASLHPNKSCYVVGGEDFKLYKFDYENGNELESYKGHFGPVHCVRFSPDGELYASGSEDGTLRLWQNTVGTTYGLWRAVSATNGNSSSNSSNASGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA24</accession>
    <name>A0A6P8HA24_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 28-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116289254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552013.1">
        <property type="nucleotide sequence ID" value="XM_031696153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289254"/>
    <dbReference type="KEGG" id="aten:116289254"/>
    <dbReference type="InParanoid" id="A0A6P8HA24"/>
    <dbReference type="OrthoDB" id="5962828at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="718"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="760"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="802"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="844"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="886"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="928"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552013.1"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127539" checksum="EC73293C167C90C9" modified="2020-12-02" version="1">MAAAQEYSTEELNYFRVCNVTTRIIXDGLRVVFKQLWDTHYQATHGQWQDTAKNGIDLYNMESSKSRKRNSRELLILRNGNSRKWDCTSLSFAILXSASIGKGLDPVVXKGVXDLRQFRNXVFAHVXDGKLTVXDFQKSIQTVIXAFSALKLDTAGIEAIKXQKTFLTEELRLXQQQLEKEKIRNEEPRSFCVLPPKPSHEVIDRSSEMNEILQEMKRLRSIKRNEITVXYLSGNPGCGKSEIARQIGENVFDDVPDNATDQVKFVFALNASSXDTLIQSYIEFAITLNCDENSTTSIGTSKDLSPEDKLIHLKSLVAPKLRKYSSWLLIVDNVTDVKSVFRFLPQAGEKTEGNGQILITTQDSRSIVAYDSYTYHLSLSRGMKPDEAVKTLSXISGVSSNKECILQVAKALDYQPLALACAATYMKRVSDITSISWEEYLQKIQQGKREATEGEYKRISVTYPQSMTAAVKLALEKEMAADKVMMHAFQFLSALGPERIPLEYVVQYVTRCMPDQDEDLVAATVFSSSLILNSPEDQSKEIGVHQVAHSCLQDIVLHKSKAEEFYFLVNVINAFSALLNVFDKDNVNHITTTKSVAVHFMHLSKHLSNFAMESLSPIKRNTNFQQGYNESVSCITTAGKVCQTHAKHEAAKTFFQTVLMMEEFYHHCNHPTFASALNSLAWSLRHLGKHEEAQKCFERALQLAIQEMAYGQNHPIIATILNNLALNLRDLGKHEEAQKCFERALAIDEMAYDQNHPILAITLNNLALNLRDQGKHEEAQKCFERALAIDEMAYGQNHPTLASTLSNLGSNLRDLGKHEEAQKYLERALALQEMAYDQNHPNLAAMLNNLGSNLRDLGKHEEAKKCFERALTIDEVAYDKNHPKLATTLSNLGLNIRDLGKHEEAQKYFERALAIQEMAYAQNHPTLAITLNNLALSLSDLGKHEEAQNYFERALAIKEMAYDQNHPNLVTILNSLALNLGDQGKHKEAQKCFERSLAIQEMAYDQNHPTLAVILNNLALNLRDVGKHEEAQERFKRAMHIDEMAYGQNHPILAITLNNMALNLRDLGKHEEVKKRFERALAIQEMAYGQNHPKLISTLNNLASYLFFLGNFEEAQKCIERALAIQEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAE0</accession>
    <name>A0A6P8HAE0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553409.1">
        <property type="nucleotide sequence ID" value="XM_031697549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAE0"/>
    <dbReference type="FunCoup" id="A0A6P8HAE0">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="GeneID" id="116290506"/>
    <dbReference type="KEGG" id="aten:116290506"/>
    <dbReference type="InParanoid" id="A0A6P8HAE0"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="115"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553409.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="56380" checksum="6C7A59E48BA17565" modified="2020-12-02" version="1">MPSPKNLSYSPFAIMNRGEVIGALNRWKWPVAGVAAAFVGSLYTLGFSQVFQLYASDDKEVAGTSSYGVKGLLKKLIHDFIQGGKSPDNPPLSPSEASMIIRKNEKRVDVNSGVVYYYDTNNLASNNPMEDRNTECRIIKNNGFLFSVFDGHGGWQCAEAVKNRLPLYIALSLLEKSELGRFEKKIIKDLLLASLYSNGSTSASSNTNETSSLTTDYTLSKKQDIFHTGPKYLVQSLKDVLNGDDKLTAEESLSLAYSQLDDDISAEAIPLKMLDDSFVIGATGACAVSAYVEGDSIYLANSGDCRVVLGSKAQSGSWVAQQLTEDQNSKNEKEYRRLLKEHPGEEGTVIKNGRLLGQLQPLRAFGDIQYKWDQVTHSHILTQIYGGPIVPPHLYKTPPYLTAKPVTTKHQIQKQDKFIILASDGLWDSLSSQQAVELVGQFLDSSKKNIGEILEKNAATHLIRHAIGGNDHHFVAQMLLVPEQYRRMWRDDITVTVVFLKSDDFNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBK1</accession>
    <name>A0A6P8HBK1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287525</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550067.1">
        <property type="nucleotide sequence ID" value="XM_031694207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287525"/>
    <dbReference type="KEGG" id="aten:116287525"/>
    <dbReference type="InParanoid" id="A0A6P8HBK1"/>
    <dbReference type="OrthoDB" id="5979063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="1">
        <location>
            <begin position="52"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550067.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41085" checksum="83CD9CA432CD44DB" modified="2020-12-02" version="1">MASAPADPIEILRSSKEKNNYTRLTRLLIAGGTVILRELLDNIIPPHHFPHVLLFPKVHRTLKRLKKKRIITSEQWKSLFPTDTSCGKSTDFDITLIFKLLRELCCLTPPPKGWDELPADDKDLTLPADLARIKNYRNAVYAHKVKIELDDSEFQDLWKRIKDALLRIVNHYNSSNPSAVLKWKTAIEKLLTDPLDIKKSHEENEKLKIWCINDPNVPNSDLKDDNARLKNQVTRDRLESSLVNVYCTWRSIMQEETDGPVGAFIILCHKNDPESLINMISDALPDGLVXKYIVAGSIVLQLTSTSDEALNELVIVLTDTKLEVLKEKYTYVPNKTEVLFEAEEFTLMVICLIFFGNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDP8</accession>
    <name>A0A6P8HDP8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rap1 GTPase-GDP dissociation stimulator 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550695.1">
        <property type="nucleotide sequence ID" value="XM_031694835.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HDP8">
        <property type="interactions" value="2374"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116288099"/>
    <dbReference type="InParanoid" id="A0A6P8HDP8"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="I or L" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550695.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="69756" checksum="8B64D2383478B46C" modified="2020-12-02" version="1">MDSELLEHFQNLNDIAKEKGHIDDASKDAIFKLLKSKQEALIVTTIQTVLESLKKTLLYLENEPDKAKVFDLLAELAKSDEVRDFCVDXGWIAIALDHLEHEDQNVVLHTLRSIGNICYNNELGRKSLLGANGADDIVRKLEFLNQNYDATKDNRMDVVICGCVLNLATDDEELAADLVNCGAMPHLLGLAHKSIHSNPVLCRMAVSAISELMNTANGKESFKESGGPSVLLSALKEDYRDEELSYLLLEALNPLVMNDDIMKKEMVNAGCTETLVHVIASCKGREEEESMKYRLETAADMIVTILTDDECMKRLFQNGDGIVVKECIKWLSSRNKHLEISGSLAVGNFGRSDDNCIKLVQMGVHKELLNLLPLAKQRPEPFKHVQAIFGALKNLALPLVNKPILLNDSCLEACLAQLSSQSPLVLTKVLGTMCALMAVPSKEETVKSAAETTANKIVNTKGQLEVLIRLSKSTGNEEVRIESCRLLALIVKYGSSQEISHKMITSGGLPQIAEIVTSSRXVVQNEALIAMTILVSFVKPDFYPKLRETGLTQTLIKLIKERKLNPQSCYNSLAYLEALSTKDYFARDLQVAGLHRVLEDLVDDENENIKKRALFMVTRLKAKQLEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE31</accession>
    <name>A0A6P8HE31_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Parahox neighbor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116288271</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OHCU decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031550902.1">
        <property type="nucleotide sequence ID" value="XM_031695042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HE31"/>
    <dbReference type="FunCoup" id="A0A6P8HE31">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="GeneID" id="116288271"/>
    <dbReference type="KEGG" id="aten:116288271"/>
    <dbReference type="InParanoid" id="A0A6P8HE31"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3330.10:FF:000001">
        <property type="entry name" value="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="13">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550902.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16849" checksum="7FED36F5DD46FC79" modified="2020-12-02" version="1">MTPLCAASVSSMRPFDGIDKLYFAMSEFIDALPTCGREGILRCHPDLAGRHAKTNELTAESKQEQAKAGLGNLTEQEASIIDSLNQSYRAKFGFPFVICARENKKDAIISGLKRRVENDKETELRTGIQEVKKIMLLRLKDLMEDRESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEV7</accession>
    <name>A0A6P8HEV7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aggrecan core protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551152.1">
        <property type="nucleotide sequence ID" value="XM_031695292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEV7"/>
    <dbReference type="GeneID" id="116288495"/>
    <dbReference type="KEGG" id="aten:116288495"/>
    <dbReference type="InParanoid" id="A0A6P8HEV7"/>
    <dbReference type="OrthoDB" id="5976046at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551152.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18314" checksum="71D8B7AB58EC7A33" modified="2020-12-02" version="1">METEEKWKFINSKIQGFNKYPNEWYIGLKKEGGEWKWVNEQILSINKWQPEWNSNIEPNGDGECVIMAKNFPPGTQGLFKDLNCKYALMFVCEYRKGNPRCKDGYYPPRCNETNLGNTSVEPTKKTIAAATQLTTTFKKKRKNQSNSYIHRDIVAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF80</accession>
    <name>A0A6P8HF80_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116288566</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551230.1">
        <property type="nucleotide sequence ID" value="XM_031695370.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288566"/>
    <dbReference type="KEGG" id="aten:116288566"/>
    <dbReference type="InParanoid" id="A0A6P8HF80"/>
    <dbReference type="OrthoDB" id="5967409at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551230.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42085" checksum="3E2DC7F9CD14FDDC" modified="2020-12-02" version="1">MRXNISLPAEDTDGGVXRHSNSSHVGNPTMVFSAVTHVNSCTKDSTKPSKNSTNARKEGHNTPTYHENDTDGLQTNRRSLETQGISKRAGDIILQSWRKGTKKQYDSYIKRWNNYCHRKQIDFVNPSIAQALDFLVELYEQGIGHSSINTAKSALSCILNPVNGIPFGTHPTVTRFLIGVFESRPTATRYTETWDVGKVLRYLKTIPSDSEKTTLKDLTLKTVMLMALVSAQRGQTIHMFSIGDMITTETSVTFIISTPIKQTKPGSKPLSVKFNSYPLDSNLCVVTTLRNYLAHTESLRGDHKQLFISYLKPFHPVSRSTISRWIKVVMNSSGINTDTFKPHSTRSXATSKATACSVPLDQIFVHSRVEFRKHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFP1</accession>
    <name>A0A6P8HFP1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L27, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551395.1">
        <property type="nucleotide sequence ID" value="XM_031695535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFP1"/>
    <dbReference type="FunCoup" id="A0A6P8HFP1">
        <property type="interactions" value="926"/>
    </dbReference>
    <dbReference type="GeneID" id="116288708"/>
    <dbReference type="KEGG" id="aten:116288708"/>
    <dbReference type="InParanoid" id="A0A6P8HFP1"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000031">
        <property type="entry name" value="39S ribosomal protein L27, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551395.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17440" checksum="1C8C6950E64C07CD" modified="2020-12-02" version="1">MAACTPGLLTRIRAPNYLINSWLPLLTCARNASKKAAGSTKNQGKNKKGKHLGVKRREGERVIPGTTLVMQRGYKFHPGVNVGVGRDHTLFALSEGVVRYKRELLDPYPWGLGRKGPIHERKFVHVLEKEPKSPPELVLVHKPQISPSHKPTSETIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFU2</accession>
    <name>A0A6P8HFU2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynein heavy chain 1, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116288763</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551447.1">
        <property type="nucleotide sequence ID" value="XM_031695587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288763"/>
    <dbReference type="KEGG" id="aten:116288763"/>
    <dbReference type="InParanoid" id="A0A6P8HFU2"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="14">
        <location>
            <begin position="498"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031551447.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="83265" checksum="1ACE28935B7B731A" modified="2020-12-02" version="1">MKTLEKRQDPSMALLCLRTTPIDNKLSSPSELLFGRKLQDNLPRTINRSANSDQITDRLREKQEIQRFYHDRNVRPLPELARGTNITXQNPSTKKWEPAVVKEKLEAPRSYLVTSQTGSELRRNRCHIREAPPAAEQPTSEYQEPTETRGNAEPLENNGSHAPGTTVTRSGRIIRPPNRYNVPQLEKMVLEGLFWSGTPLLESVGENEPEVVRLRETVRQAIRSSLKPIRAYAKQYEKYLDLFNLDVNEYLQQYDSQEHTAAEVKQEIERHLKDKEVLENTLPSSIVIGSYWVMTEGIKKELAKKRKTLANAVIELLAKKLRKQADEVCEEFKFIARRLYDKPNSIEELAEQREYMKTIPDLLKKNQELIDKAMVDYELIEEFNYSISAEDFSAKWTCISWPYKIQQQMEATEQTLEADEERFQKNLLADQNNFQDRLDSLNMAVAGFAAHTDITKAHEIGNEVRRLVKQMKECQTLAHTYNNRERLFNLPVTSYEKLNRLIKDFEPFKNMWLTASDWQKWHDSWMNDPLTTIDPEQLEQNVSNAFKTIFKCYKHFKEIPACQEVAYEVKEKIEAFKPYIPLIQGLRNPGMRSRHWEQLSKDLGFPVVCNAQLTFTKCLDMGLQNHIDVIAKIAEVAGKEYSIEQALDKMEGEWKPVVLEIVPYKDTGTFIMKVGEECSQLLDDHIVMTQSMSFSPYKKPFEERISTWESKLVMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIX2</accession>
    <name>A0A6P8HIX2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031556334.1">
        <property type="nucleotide sequence ID" value="XM_031700474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIX2"/>
    <dbReference type="FunCoup" id="A0A6P8HIX2">
        <property type="interactions" value="786"/>
    </dbReference>
    <dbReference type="GeneID" id="116293079"/>
    <dbReference type="KEGG" id="aten:116293079"/>
    <dbReference type="InParanoid" id="A0A6P8HIX2"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556334.1"/>
        </source>
    </evidence>
    <sequence length="650" mass="74058" checksum="E0E7D74611D0C99D" modified="2020-12-02" version="1">MPCAQATHHWIPRQHEMGHNVRVGMPHAFRQQEFSQKMRFEVFYDESMKDLSHSKRLLVRNKLIPEAVAYFHNTLSVRPSKSNITLQRTCKNNAYYLKDTSGDKNGDVQFCKLECIPTKCGPVAAPKQHLDQCRICDTRGVECLTMPGMEWKDGPGVNKDFILYVSSIQTSHCYSANAVAYASYCQQEQVLDRPVAGFVNLCPNRLETGTVHYSSLVSTVKHEIYHALGFSAGLYAFYRKRDGSPYTAREKNGLPSYNKKYNLYQWSPSVVRKIERKKWAVRHGYVTHTVHMIVTPRVKENVRNHFNCKSLEGAEIENQGGLGTEFTHWEKRLFENEAMTGTYTQNPVFSRLTLALMEDTGWYKANYSMADTLDWGKNLGCTFAKSSCKTWMEQNMEDMSLAQPFCFTIKQEPLRMRCTHSKMSVALCNLRQYDKVLPDEYQYFNFLPDTKGKHLGTLVGDTAYYGGAVALADYCPYYQKFTLSDKGGKKRETTCTVTDNAPASMDNFALESYGTNSRCFEQGRQWTGKKGLLTRTMLDWGSGCYRYYCDDGIKVHIGNKVYSCFQEGQHIEVNGVLGEWAINGSLICPSCRQFCGDSTGCPMEIVDDNTEDGLEKDKKSLATNTQHAPRHWKNIVLRSMLSVLVSIYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ91</accession>
    <name>A0A6P8HJ91_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116289941</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116289941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552752.1">
        <property type="nucleotide sequence ID" value="XM_031696892.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289941"/>
    <dbReference type="InParanoid" id="A0A6P8HJ91"/>
    <dbReference type="OrthoDB" id="5984148at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="843"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="877"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552752.1"/>
        </source>
    </evidence>
    <sequence length="1124" mass="129440" checksum="A823DEF09AB7435F" modified="2020-12-02" version="1">MAANKEIISSMTAADIKNELEANGLSTIGTKTELVQRLYSFRKGKQTPLIAPSFSFEYTPSKLHEEVKGLIEKVSEREKEIDEKISSQFEKLSKQLMLFVGSHVQNEHISSDVGESEKVHEEKAVVTDIVKLNRKLKMFGRSIEMIFAEIEHLQKNANARLEMESALRRLNNLEESYSNIVQEIIASIKDEIAVDEEIQKWASFQQEIIRISRKAENYISLRNTEESQFSXISQVVEHMAHKTCSGVGHLRLPKFTLPEFNGDILEWVPWWDQFKTCIHENETLGDREKFNYLRMYVTGTAKRAIEYIEVSXENYSRAIGALQRRYGRKRIVVEHLVESMLSIEKKEKVNAKSLRYLYDVMVNRYHTLESYEPNXKYCHRILVPILQSKLPQEVRRKWEYELSKIENEEEDKKITVEYFFDFLRSHVMSEEASEKSRSVFPVRETEERNTPRTRYSGRISTDKYIFPSSATSLTGNSKQEDFKQRNQSIKSVEERLQIIKEKKLCFNCLRPTGSSHTSATCKRPGCLVEGCSKKHHVLLHRAQKENDEQKASTTMSESQGSLSNQVKGHSGLVTGVFGADVNNQIRLLPTALARLHCNGKELMVRVLVDSGSDHSYIRREVAQALNLPSNGPSKSMTISMHGGQTRKTKVENVNFQVSPIHDFNKKVELSAWSVETVCSPLEPVQVDMSRYNHLGDLDFADEYPRGTVAIDLLIGADQWDQVMLNGIRKGPLHTPFAMNSIFGWLLLGCSXKSXMQDIQNDKLATNLNTVVCIREDAENDEDSFSLKKFWELESIGIIDQKKKLSSEEDEALQQFQSTINFKENRYEVGLPWRSNAPKLLPNYQQASKRLTRVEEMLRQNERKETMYKEAMNQYTKDGHAREITEEDQQASKIYYLPHHPVFREDKTTTKCRVVFDASAKNRQGISLNDCLLPGPALQPNLVSILLRFRLHRIAMXADIRKMFLQVKLALEDQNVHRFLWRESQDESPKTYCMTRVTFGVVSSPFEAIATVQHHAKANEDKFPTAAKEVVKNMYVDDYLSGEEDEDKAYFLHKDLYDMMKXGGFELVKWYTNSEELKDRISPELRGPTTLVELKNEAEXLKALGISWHTSKDIFLFNQGENLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJC8</accession>
    <name>A0A6P8HJC8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Opioid-binding protein/cell adhesion molecule-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555946.1">
        <property type="nucleotide sequence ID" value="XM_031700086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJC8"/>
    <dbReference type="FunCoup" id="A0A6P8HJC8">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="GeneID" id="116292734"/>
    <dbReference type="KEGG" id="aten:116292734"/>
    <dbReference type="InParanoid" id="A0A6P8HJC8"/>
    <dbReference type="OrthoDB" id="5963605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="69"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="162"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555946.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31934" checksum="A73F9BA5E410DAE8" modified="2020-12-02" version="1">MLNKWKWNIHTNTCPARLLNPVRVSKESTATLVIHNVTLADSGTYGCVLVLTTRNPITSKVKLVVTSLPNITLNPSSSIIRVNESEGLFISCSAVGIPEPNVTWLRLRDGGKFRKNQGVGHVTINLSNITRNDSGIYNCCATNNPKENPTCRSTTISVQYKPEIDVVQSNDTVSSYNNGTVTIYCLANGVPSPLFTWYDPRNRSILTGSHTVTGVGVLELVTIDAGSYGLYKCKAENLLGYDEHIINVTQTGLKHLILLMVLMVLFMRKQSSKSCFENQVRQKLQKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJR4</accession>
    <name>A0A6P8HJR4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 501-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116290004</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552830.1">
        <property type="nucleotide sequence ID" value="XM_031696970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJR4"/>
    <dbReference type="GeneID" id="116290004"/>
    <dbReference type="KEGG" id="aten:116290004"/>
    <dbReference type="InParanoid" id="A0A6P8HJR4"/>
    <dbReference type="OrthoDB" id="5984310at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000608">
        <property type="entry name" value="zinc finger protein 286A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000992">
        <property type="entry name" value="Zinc finger protein 320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF191">
        <property type="entry name" value="GDNF-INDUCIBLE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552830.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="55656" checksum="CC83B28C7074FFCC" modified="2020-12-02" version="1">MYIDTSHDQETDHSDSREDMERQGVHSEGAQTDHIKGCTSSSIENIVEMQNCPPAENDQTTCADFGTSVSSTEFDGHGVNCLGSTSDGRDIDGETSSCVEQKDIRSTVSSNYDDKHHDDQHKELNLNQETHRCHTCNTAFTRHSQLEQHERIHTSVRLYKNDNCSKAFARKDNLKIHERIHTDVKPYKCTCCDKSFRRQENHLTRHERIHMGVKPYKCTCCDKTFTKQSYLTIHERIHTGVKPYKCTICEKTFTRQGSLKMHEHERIHTGVKPYKCTICEKTFTRQGSLKMHERIHTGIKPYKCAICEKTFTRQRSLKMHESIHIGVKPYKCTICDKTFRQQSYLKVHERIHTGVKPYECAHCHKRFTEQGSLKIHESIHTGVKPYKCAICEKTFTRQDKLKMHERIHTGVKPYKCTICVKPYKCTICDKTFTQQGSLKMHERIHTGVKQYKCTCCDKTFRRKDRLKKHKRIHTGVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKQ2</accession>
    <name>A0A6P8HKQ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactose-3-O-sulfotransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555483.1">
        <property type="nucleotide sequence ID" value="XM_031699623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKQ2"/>
    <dbReference type="GeneID" id="116292336"/>
    <dbReference type="KEGG" id="aten:116292336"/>
    <dbReference type="InParanoid" id="A0A6P8HKQ2"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF85">
        <property type="entry name" value="GALACTOSYLCERAMIDE SULFOTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555483.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="56109" checksum="38043F6033C0AB3F" modified="2020-12-02" version="1">MRKFRNCRVKRTFASIFVLVIIAAYITLNKSINQNTKRNVRTDERDPYRFQLQHAAWVWNDDVVYVEEKSRKPREVPTDESPQFEVITHTNKSASLAQEGTDYGQNKFLGLEGVEDYILSKDDYREQRKVPNRRIEKCKFPLFNILFLKTHHTGSDIITNILNRFADLRDLRVAIPNGGVSTFYWPARFHWRHLDLSIHDGVLPNILCNHARFNGEIMDQIMPQGTVYLTMLRNPETLFESTFDHEHFTAMLDMFEYDDPIGSFLENPKMHIEHVIKHNMFKDNLNLIKNGMFFDLGLRTADYHKPQVFKDAILDISDKFTLVLIYEHLDESLVMLKRKLCWELDDLLYLKSYFIEKTSYRNFTEAQREQLRNWSKADSALYEYFNRTLWERIANEDNFEEELGLFKAKQRQIEEDCEDATVDDGVFDSDETSSPGTEKMNKYLCHKMTMSAGNYLEYFRTKFAVRKHGKSYTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKY5</accession>
    <name>A0A6P8HKY5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116290391</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116290391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553270.1">
        <property type="nucleotide sequence ID" value="XM_031697410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKY5"/>
    <dbReference type="GeneID" id="116290391"/>
    <dbReference type="KEGG" id="aten:116290391"/>
    <dbReference type="InParanoid" id="A0A6P8HKY5"/>
    <dbReference type="OrthoDB" id="10051448at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031553270.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14309" checksum="8DCAB501E15A6201" modified="2020-12-02" version="1">MGCVFHWSQAVWRKVQELGLTLPYENDFIRKLLALPFLPATEIERVFNTLMQQATTRPLQDLVEYIDNQCVSSATFPPEEWSVYSQAIRTNNDVEGWHKGLNGCASGRVHLLFYLLRLSLPQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKZ5</accession>
    <name>A0A6P8HKZ5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557064.1">
        <property type="nucleotide sequence ID" value="XM_031701204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKZ5"/>
    <dbReference type="FunCoup" id="A0A6P8HKZ5">
        <property type="interactions" value="3461"/>
    </dbReference>
    <dbReference type="GeneID" id="116293741"/>
    <dbReference type="KEGG" id="aten:116293741"/>
    <dbReference type="InParanoid" id="A0A6P8HKZ5"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="138"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557064.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31165" checksum="B5F07A5E29A21339" modified="2020-12-02" version="1">MSTFGGESSVEIDQDFFDSGYSYNSQAQSSNYYDQTEHQQPQNQSEYAQSYSQYGQTQSATGYNSYNSSSYPNNTGFYNPQTYDYGASGPTAMSEPSFSGFMQPKQTSEDYTSFEDEPPLLEELGINFEHIWQKTLSVLNPLQQIESNIMDDTDLAGPLVFCLAFGGFLLLSGKVHGFGYIYGVGVLGCLSLYAILNLMSMTGVNAGCVISVLGYCLLPMVLLSGISIIFSLQGMLGTVLTAVTIGWCSLTASKLFVTVLAMDSQQLLVAYPCALLYGVFALLTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLJ3</accession>
    <name>A0A6P8HLJ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Receptor-type tyrosine-protein phosphatase epsilon-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555818.1">
        <property type="nucleotide sequence ID" value="XM_031699958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292611"/>
    <dbReference type="KEGG" id="aten:116292611"/>
    <dbReference type="InParanoid" id="A0A6P8HLJ3"/>
    <dbReference type="OrthoDB" id="5986740at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000080">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="427"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="600"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="714"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="887"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555818.1"/>
        </source>
    </evidence>
    <sequence length="984" mass="110003" checksum="0834C0964C6DCE14" modified="2020-12-02" version="1">MNSSCCSLYLHDLLVCAEYLISIKGYTTAGPGPASNVTSLETSAPGPPSGLEVLTTKKRIISLRWQKPESVTETIKSYTISFEGKKNYNSSFVHSGLLLDESTEKEIPNLYPGTLYTFQVSATTACGKGDYSLSSSSNTKVDAPPAPVVXFVGNITSEVNNITVWESSDINGPIKAYQITVINVDETSSIDETKLKRYEEAEKGKLHFYIAAELREENGKKFPTFFTLGDEKEYHGYKNVKLKHGTKYQISQRAMTIQEDGGKKTFLPGLSALIATGQVPVNKGGGKTQTGDTNNGATKAAIGGVVAVLLVVAVIAGAIFFWKRRKGERTRKNERESLDDLDNALDLNDIQNEQDKKGSSTPNSRTNLVDQGPNGASNKQGGGSTNGALHDEDADLYSNAETVRHQPIPINKFPXFVTEKKSGDHSFKEEFKTLSNGQQYPWDNARTPINKPKNRYANIISYDHSRIILQDSEDGSDYINASYIHGFDGTPRTYIASQGPIPTTVSDFWLMVWQEKVKTVVMLTNLMEAGRVKCHQYWPDSKDTYGPMTVILHRSDVLADYVVRVFFVSKRGEEGKIQVNHFQYTAWPDKGVPQHATSVLGFRRKVRANYASVGGEGPLLVHCSAGVGRTGAFIAVDAMLERTRKDKTIDIFNFVQMMRNNRITMVQTEEQYAFVHYAVLEALTCGNTEVPVMNLNIVMGKLSKPRPKDQMIGYEVEFKRLNHISPALLTEESSEIGQREENMARNRYPDVIPLDCARVLLSNEKQNYINASFANAYRERNAFIMTQAPLENTIYDFWHMVFQYKIGSVXMLNILQEEDEIFTPYLPSEGKQSYNRISIEITDIETKGPLVIKKCKLVHPMEPQAPHNFIHVQHTKWPNQGIPESSQSVLDMVTIVQRSQQQSGNTPIAVQCSDGVGRSGTFAAVYSLLERVKTEQVIDVFQAIKVLRLGRPNAVKTLVQYKFCYMMVQTYLDSFNDYANFSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMF9</accession>
    <name>A0A6P8HMF9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiosis 1 arrest protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557539.1">
        <property type="nucleotide sequence ID" value="XM_031701679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMF9"/>
    <dbReference type="FunCoup" id="A0A6P8HMF9">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="GeneID" id="116294137"/>
    <dbReference type="KEGG" id="aten:116294137"/>
    <dbReference type="InParanoid" id="A0A6P8HMF9"/>
    <dbReference type="OrthoDB" id="6433824at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051308">
        <property type="term" value="P:male meiosis chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007127">
        <property type="term" value="P:meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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            <position position="1"/>
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    <sequence length="487" mass="55209" checksum="722D1FF66C43AE60" modified="2020-12-02" version="1">NLFQLQHVKNNFPRLHSALEELKFFTKDTKQQTESKTTEVLLQGMQDAITQFKRQSQSFRQINTSSCQMEICVFTCRKSSNVTRKIEEISSNLDLGSIKKIQIAAVVDNTEDQDVQEDYNNKEQETSPSSSTETGMTGCGIVDTIVLQKDPSSFQNFFKTWLIDCETDQEHLRIELPSPCALNEEDMILEPMHNNTVTLKCDLHERLISPSNLPYRSQFEVNAECVPVNKSWACNTKQNGVNSYPVHTMAVDRLIKREAICESVIFGMPYILRPTVCWKLDWEELERNQQYCHALCHALQERDLMVLLKTKTDTKQGQQPSLPIGHFILLPSHGNTMLLKSIATNELMLPVDLNQPVEGPNIEATEIIGACLDQLHIVDAYNPLLVRSNLYKCLSSNALKGNKGNVPQRSVKRGFQVPQRYQQENNNNQVAESRPNHLKPTRVPAVPKRVIFSKEGNVNKATAIKRSRVAPALDIYVSSPPDFPDDV</sequence>
</entry>
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            <begin position="1"/>
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            <begin position="57"/>
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            <begin position="149"/>
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            <begin position="207"/>
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            <begin position="335"/>
            <end position="362"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="RefSeq" id="XP_031557689.1"/>
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    </evidence>
    <sequence length="369" mass="37668" checksum="3FEA32F4BE8A6DC2" modified="2020-12-02" version="1">MDDLVSKIDKAFSEKPAFSPSENDKKPPGGTGNIGSSTGNTEFNKLFGFSDDSSKNGSLSGDLLDMFDLDSFSSPKTQSPAKSSPSSLSNQSPRTQKSSSSLSMSGSRSMMTSSPTLGGSIGGTPMVGAKNNGSTSGSTGSKQVGSSTFGSMPSNLTGMGSLSGTNMGSGKHSNMGPGNYSXMGSTSHSNMGPGTYNNMSSASYNNMGPGSMSSSSMNSRGMGAPSGTWSMAGAGGMGTTTSQSFGAMSSGHSMWNPSSTTSRTDQNKSASALDSLYSPEMSHLQNKNKPSLSVLQAQKQSSVAPQMNTGMGMMGARLPYATAPMTSAGMLPMQSQSMMGNNPRSPNQYQAPSSQPGIGSSNDLKDIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN15</accession>
    <name>A0A6P8HN15_ACTTE</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC116291068</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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        <lineage>
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        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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    </evidence>
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    <sequence length="267" mass="30233" checksum="CFA98026BB2CA205" modified="2020-12-02" version="1">MFSILVYSKLFKKVKRNINPVEATRIIKMGKYSKFTDLDHQVKTFRWPYWLLPLLFLSLLLVLGLFIFITIHSADRFGCLFHCEQKIDDGGVVPPNDGPFDIRRGDHNVTEHVSTKKPSTGTDSDEMIMGSTPTPTPTEATTQITVKGKLLFPSDRVPDSIPPNSHLIVKFEDSSLQDASSVVLGKTLVDANTYKKGTNLTYKIVCPKPKNHHDFYSVSATLNMGWTPTKEGPWIRHGDLFTDTMYDVKIKNNVTVYEKDITFAYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNB6</accession>
    <name>A0A6P8HNB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tuberin-like isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="primary">LOC116291140</name>
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    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="6">Tentacle</tissue>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
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        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
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    </dbReference>
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        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="498"/>
            <end position="535"/>
        </location>
    </feature>
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        <location>
            <begin position="1674"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="1946" mass="218175" checksum="9E824C2EA5256950" modified="2020-12-02" version="1">MSKTHSNEGFKQRFKQFLGIKKGHPISISIHDGTKTDEFTFTNELLQEMGPESPVASRVKLLKELCEFLVNRKLEDHATEAAWQAVEDLLQHNHPQEARHIALQFLSVLVTCQFDKLHILRAHFFKVVVLXKIPEDFTPRIQLLKALSDNGKDITYFEEDIGTFLLSWMPEVIYTDRLEPLMSLLINVFHYNSSYLDENVVAGIVRENCNMARTLKNEKSVEFSLCLLDAVVRYSSLPVGSVHEFISALCSTVNLEKCCQHSWKIMRNVLGTHLGHRGVYTMCSIMESGGQQIPNVMQIRGAVFFIGMCLWGSQRVTTLKHSHSSVLPSMLQSLFCHHPIVSLEVTLSIQRLVKKYGHELHVVSWDSVLDITSKLQSLIKEQQQKETTLIENLHTLLNYIEELMESGKYRGSEERFYDIVEKCSSKRPESSLHLLVSFRAQSVHPAHAGWLNNLKNLMEKYFRYEIRTSVRVKALDVLSFVLTSYRHWYEEELLDLVVLPFLGSIADDQDVTVRTSAVQLLLDLSQTCDSSKCMDILNIVEKVISRRVEVPGKMSPTESSQEEEVLKDIKTAISALVQVFKVKLFRLPHSHAQKVFSLLVTHLKAHYYHGYTTNIASVIRNIVFECLLSLRCDTSHRLGFVEEKSGEHDKVSLYFVCTPSALTSSSESKPCCSSPLGVIPYSEAFNVILNCLQYEWDWRVLEHVLSELPDVLQNKTLVLAADPSLNIMSSVLCKMVSDSATVLDLQNVPQGVGRTGFHALIFPVLTVLATYHFRLDRTHQCELVQSLELGFLSKCANLCVSSLMLCTMEMQAVMNSLLPAILVRLSQISATVSMAVPMLEFLSGLVHLPHLYTSFKENQYKSVFAICFPYTDPFRYSQYTVTLAYHVITAWFVRARVAYRKDFVGFITKALKTNITKPERYEQRGDSPTVGLRSRSSSAAQQQSSPQPSNRSASPSSSMQAKENESAYEFHKEMSEVCMDMMARYSFAMSLSQPKRTAAMEFLLSRGKTRQWIVGNSVVSITTSGTYIELDGVCENCLPLHKRGRPDSKIVMSSSSASLLLKRRKSKEKILEEYSLSAKKDASTAHDDKGFDGWSTVSQDANLKPDHYKQSGRKSPVGDSGRVDATSERSKTSEPGDSTDHGKSGEGLKTQATRGGTSDEIVDCHCICQGWAEIVIRRPSGNISWTMRIQNRLVGPLLTMPEVDGDVSTALVDDSHIKEYLLVPDGDTDQLKIRTKSREVLSTSTDSDVLLIELVKKEKQKDTKDSGETALKEPDDKSTSEASPESQQEENDEYLNTNTALSLQGFTPSSPLPSPYDFSGSEMGSTNNRPRLLSNSPRRGPFAFRMTRDSESSDQFEQKSLPQDVPPSAKRQLRYEKPELGVSPAELSRPEHHTRDHNMYLSSSEMYRLASDDGDVKQTFEAGDKSESKHGGKTSEPTESELARSKREPVKLRLKGEARAKSQRPKSLPLECLPKGPCSDTSHATQQPSHATSSHVNREKHENHLKEESRNSHSASTSPRSPVKTKLKKSFSLSSPRRIRKNVELPGESKSSQVLRNTSADDMGYFSKVNKSSSSPELSSPTLNRASMLHELGKKKKTPTIGTKQHDTSGTSSKDGPGVSSTRDPPKLVTASESYRYPLDPNFVFLQLYQTAFSGSSKDKPIPLPEGEVIDRAIKCLDRIPPYDTHKIGVIYVGPGQHNNETAILRNVYGSSRYMKFISGLGSLIRLRDCPLAEIYTGGLDREGEDGEFSYSWQDSICQVIFHVATLMPTKDSDPGCNSKKMHIGNDFVTIVYNDCEENVAFGTIKGQFNFAELVITPLDNECNVIKMRFKETLKNLYVDTGPRVISDSNLPMLIRQLAIHINMASVLHQGQKRTTDAYGCNWLERLRQIKRLRNKAVTESVPPCTPPPSLVKSPPGSSAFGVVVPSTLTHPHLLDFTEYVTNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPS2</accession>
    <name>A0A6P8HPS2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116294188</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557596.1">
        <property type="nucleotide sequence ID" value="XM_031701736.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HPS2">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="GeneID" id="116294188"/>
    <dbReference type="KEGG" id="aten:116294188"/>
    <dbReference type="InParanoid" id="A0A6P8HPS2"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="354"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="446"/>
            <end position="453"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557596.1"/>
        </source>
    </evidence>
    <sequence length="707" mass="79097" checksum="C692A34C5D1615DB" modified="2020-12-02" version="1">MDPVETRSPLQTQDQNVMAKRLPQPSKLRPPSAVKRPCVKDSMDEPKLKAPKCDLAIPKSSAGSSAKPQLPTALRRQTSSAVVRRTTTTKNNMPPPSTVKPVGSTLRRQTSANSLKKGTASSNTKTAGKATSSKLSNGEAKQLPKVPGQGKKRSTWDYKGRLEDMENYLSNTKYLMDDMNKSMNHNRERIEYLESVKKELEGTIEVKHQQSEQASARIQDLQAHILITEEELNSLKLRHEFEIEVKENKIKSLVKEKETLERDLKVSENEVMALKTAIAQITAQTSGLNAELEATKINLQSNIELNRCKDERIAKLLKEIEEQQHLIDEKDSKLRDEETIRRKLHNAIQELKGNIRVFCRVRPALEAEKNLPLANFTFTDEDRGIIVEQSIASEDVAGNKKAASRYEFSFDKIFDKGSEQNDVFQXISQLVQSALDGYNVCIFAYGQTGSGKTFTMEGNHGNHDQRGMIPRSMEQVFETAARLQEKGWKYTMEASFLEIYNETIRDLLGSGDESVKHDIKIVNNGKSNTEPTEVMVTNLKSFEVTAVTQVSDLLQKATQNRAVAATKCNERSSRSHSVFILKLTGENSLTGEKCQGTLNLIDLAGSERLSQSCSKGERLRETKNINSSLSNLSNVIMALANKDSFVPYRNSKLTYLLKNSLGGNSKSLMFVNVSPREESFQETLCSLRFATKVNQCNIGTAQKKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTS6</accession>
    <name>A0A6P8HTS6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292809</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556017.1">
        <property type="nucleotide sequence ID" value="XM_031700157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTS6"/>
    <dbReference type="GeneID" id="116292809"/>
    <dbReference type="KEGG" id="aten:116292809"/>
    <dbReference type="InParanoid" id="A0A6P8HTS6"/>
    <dbReference type="OrthoDB" id="5977824at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027654850" evidence="1">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556017.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21120" checksum="9C6EB369BAF55555" modified="2020-12-02" version="1">MMFQTVDLLLVGFVLTGIMIKPSKCQPNSTIQPNEPKCLTYLDEVVQILGSKIPPIIDSRMTDNYYNISRALYPSIDLPALYVKVTIQFLKDYQNGTKIIDGDTMKLTWSTSCTYVSVKHISLFAMTVFSLATIYPQRRETELTITVLPLCKDSPYKHDDEARTKMWRYIVSTFSVFRMLLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU20</accession>
    <name>A0A6P8HU20_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Centromere protein K-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116295264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558896.1">
        <property type="nucleotide sequence ID" value="XM_031703036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU20"/>
    <dbReference type="FunCoup" id="A0A6P8HU20">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="GeneID" id="116295264"/>
    <dbReference type="KEGG" id="aten:116295264"/>
    <dbReference type="InParanoid" id="A0A6P8HU20"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11802">
        <property type="entry name" value="CENP-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="96"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    <evidence type="ECO:0000313" key="9">
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    <sequence length="265" mass="31491" checksum="D3FC8D7E518670BE" modified="2020-12-02" version="1">MEQFLKAKCEETWEKLYETHSRIQSKKNNYPPTGIDNNDDNDVLKAILRAKEKKLQAEITAMKNENIEVPEKEELLSEEELKQKLEERTSHLESTLSVIEMQKQDMMNELEREEEIFQQNLEIQKSIQRKIMQLENEKENVKSGNSQVRELEKKIRITEENLRDLLKKLGAFIKEHFPIPSPEDLKEKEKKLPPRQRVVDAAQKYSSFHELLEDLLNKMWQTPHDPYVKIQPNHWPPYIELLLRCGIALRHQHDCNLIKLESFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUG1</accession>
    <name>A0A6P8HUG1_ACTTE</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116295256</fullName>
        </submittedName>
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    <gene>
        <name evidence="10" type="primary">LOC116295256</name>
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    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="10">Tentacle</tissue>
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            <location evidence="5">Nucleus</location>
        </subcellularLocation>
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    <sequence length="304" mass="33790" checksum="DC5798D2CA6ABE2C" modified="2020-12-02" version="1">MEQRTKRTCVKCRFHGKVVPLKDHKSNCPYKLCSCEQCSTHDKSKEGKRLANQPQTTNASCTQTVLDVAEVDLSSKVVAKNMSVTAKKTEQKKKQLEKHRELYAKVNEFSKDISSAVPDMNPLQVMKTALQLHQSGLSTAKPKARSKEREAWQAMPDLPIPSARKSYILEEDKLDHLYGAFPDVSRSTLASLLIHEKGDINRVITSWMVSDEESSTESSVADVFMNEELAVADIATKTSISKQELNSILDNVKNQELGTGANILSFHSREARQQAPSVTCTGFTSKHGNDNTFSRALSSQTDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXT8</accession>
    <name>A0A6P8HXT8_ACTTE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294094</fullName>
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        <name evidence="3" type="primary">LOC116294094</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </location>
    </feature>
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            <begin position="116"/>
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    <evidence type="ECO:0000256" key="1">
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    <sequence length="136" mass="15539" checksum="2C8AAC71587D4CD7" modified="2020-12-02" version="1">MVFAIKMSAKGYESDEDDKPKTFEVIEVFAKGEDRFVYEPLGIVYRDPRDDGFQAERGYIVDTISTKAGDEITLIMNTTMKARVAKITRKGPNDYVVDKEHDVYSKTVDINCRAKKTTRIRNNRGRRRGGSNQNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0A0</accession>
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        <name evidence="5" type="primary">LOC116297120</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <lineage>
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        </source>
    </evidence>
    <sequence length="1966" mass="222766" checksum="D669224B6533DCA8" modified="2020-12-02" version="1">MTEILCRWLNEEVGLSRQIDHFNFAKEFATGYLLGELLEKHALQNDFAEFSQSITADSKLNNFTRLEPTLKLLEVPYDTNIAHAVMNENHSVVTRLLYQLFITLGKKNKMGLTGVAMETMRPSGPVKLESIESGMYKERLKQLTKRQVDLNFENLVQRYQAKQKQQEELAFKAKFEEEEKFRKHQQAQRIRGLEKSRQVRNKQQEMMDKIREATVKIPKPPDAKKSGKSRGEIRRQREAEEVKANIDAFEASMKATIPPVSPAALDDIPRVSRDVSVDVEVFIRQDSAKQLPDPLSVIKPAANKEYINKIRTRLEEDAVAREEREKRRRRVLVEQLKAHEAQEEAHREEMLVNRLMRQSQQERRIAVQLMQVRHEKEVIRQNRIFREQQYAERRLKDFDDALEREAEMCRQAKLEYAEETRKANELHDRLADERRQAKYNKHYDICMQMLLEMIDFSCKVGEYRELTEKLVPAKLYREWKDLFLCGLPLYEEKEAELSPEELEKEREIKAEKERLLDEGDFMEYKNLVGEWVPGEGQDIQCPPKDNAVLGHIVQRLFNIVSPPQPPPPPPELPPFPIKACFLGKFFSGKSSVIKKIAEYHRVVRLSMDTLVTEAIEAHKKGEVYEEVDGEVKVLQATASKRPSITDEPIESPKPEAQGASESRVVSAGSAAVSVGSAKETPDPNKISEDQLGEKSEEQDEKRDKTKEEIAKEREKQTKSSAASEKKAFEVSMYKSGPKGPKPTPRAKLGARAYAYLKKGKPTPDQLIIEIMVEAIRNVPEGTGWIMDGFPATINQAKILEKALTGYDDQKQAKESKSAKEPGKVSRTKKSRLAPDPHPAPEAPPHKAGIDLVVLFDLPDEVALRRAEGRTFNPITEEKFHQEYNPPIEGSYTGINKQEKVVTVVDSSNDREQVQQRITGFLDAWPKLEKWFTRFGVLQKLNADKPQDDLYEEASGILNETYQKIMAPPEEPASEAASVQQSVAPEGEAQPLEEPLPTTGGAPPEGGTPAEAQSTTSPVAPSESAISKSEKGATKTKSKTGSPKGSRKMSKKDRSPSPSASKKGVKSRSPSPPSKKGSGSRAGSKSPPPSRKGSRPGSKGSRPGSKRAKSPKKGEEPEEETPPEPEGPPEPEPGSDEWEYIDQPIEKEFASVLARQWENNEDIYIETCKTIFRKIRHERELMYRYFYGTRKDFVEFLKRPDEKQEYVLQWQKEFNEIAEDMRSDDDTKAEWHQRVDDLCDRLHEICDNRKEMAERERQTIMNEGWMEDRLGVLTNHYIGLMQVEVDRYQDTIRLLRDYYMGMEVSSGKVPCEPVNEYVRLPLVELPPTLRPQSASSRASDSTGNVNAEKSETKSPSAKREKDKGSPKTPEPTEGVEEEQKPRIPLVPRRPKSSEGGTGKGRDKRTGQKKDKQSDPDKPETPVPPSDPDERLVFDAYMLALTVIEALAALDVADQEAEAQRQLELDREKEKELIQKKVKESKGKKGRKSPVKSPSKTETPPPPPPEETEGESEEDKLKQKIKERSRKEFLASVASEDKGLKSRLEMVKVHTMAVLQELKGKAESMYKDMEDWLGERFLQEVESIKAMAATIRFAIEQENKLQEETILEDKDFIVDLDTKTFKTPTPPPPLVQIELPTSDSFTVSQILNLCNQFIEAAPSGVISNRGFCDVIMDLANLTFGTESLPDIWMNITQQQLQDICSLLSQDSEFIDWRKFLLAAAQPWTPPSKMDLLMTLERFRTVDQGGVGLIDEAQYAEVDMWFSKLISDEEQPEVPELVTAYDRLEKLKEAFFYIFANHNLQPAPLLDYANMLMYFAADSDPMEGFLRALSISTGQPMPSSDSLSSIPLAESQATEIQVPLIQTPGTPPPEMESLVRLDDLITVLHHGQSRLGDTHRLSVTSDPADSFARERLAGLFIELGADDEEEALPFHLLYQHPIMQDCLQTCMLFKSADLRSAFKGNGSSSDTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0Y9</accession>
    <name>A0A6P8I0Y9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116294985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558547.1">
        <property type="nucleotide sequence ID" value="XM_031702687.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116294985"/>
    <dbReference type="InParanoid" id="A0A6P8I0Y9"/>
    <dbReference type="OrthoDB" id="5966378at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34400:SF4">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Iminophenyl-pyruvate dimer synthase" evidence="3">
        <location>
            <begin position="657"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558547.1"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124242" checksum="492EE3552391D6BB" modified="2020-12-02" version="1">MIFLKGSCLNFVICFFVFGSIWMASNKEALVKAETKNAKPTTESTNGRPSSEQDDPDDPYMNYLFHPRLTFSGTFQSDVSTVNNIPSNFDSANFVQTNYLTHGQLWNSRGTGEWNVDASVTQVCYVNGTCVADNNEEEPILEATFQEGGNETIGKMVDLDTEAQMFSEIWGWRLRIGDFFSADFTPVPFQYIWPKIVDPGTLSPFGSAYQSVLSNIRWIDDNANSPLIEEWKKIMKSDNVESDKLSIRFNVDMYELDPQNNNFTYGRVTGSIGLLGIKSPPFFSHGRMLHAKSPNVQNAPFIVDKKKKKAYIDFGNSLQITRNGSFDTMDLNNLYVGLPLDLSETSLNITCDNKFVWLGIVNQTAPNWYRNYAGIQSFPVMRAFSEREINMLGSNPFVVVKVTGEWPALVCKEIVLAEDIKGFDIHPYDDWTMHKEPEESVNVRVIATKFGEPLXNVKVHFEANDCPNIFADGPPVAVPPIPPPEDVLTNSEGIXEFKIMTKDPKSPRDYIDGQLYPYTYSINNEEHPKKNFSLMCKIDMFXLLNNLIVIAVWDQYGPVSEPTWLDHVYPIFKQYANLYPVMTENIVDLGNYYEVTERKKAIQMSMELPISHPNYMPVTRDLSPSKSKVILDWLKKDDPPTGKPKDYYTVENLRRDLQTALQLEQATIPPYLTALASIKYNYNEDVQSILRSIVIQEMMHMNLVANILNAVGGSPIFHSKDFVPFYPSRLPGGIQPDLVVPIEKVSINLIRNVFMTIEQPGVTQERKSSFNXMFDFVEKLKCSGVSKYSNQESCIVKHQTSEIVDPLIDGDYVPCLVQGFEEDSIANFKLRQYGMSRSRANKKDKDSKDKKFFPNYHYEYERHHNTIGDFYNHMLNSLGYLTDCGKNNSIFTGDPNRQVDFTHWSVHGRSLNVTDFVSAVEAIKLIVEQGEGSSPCNPMAWSNGTVKDLSHYFLFYSIAEKREXQVFNKHHQEGTGTDQSTKVNYEGCNGTYFFTGPKIPFDPDGVWPMVPNPKMXKFKEGTKAYLRADKFNKIYTKXLKSLENVFNGHPESLKDALGLMFSVNLHLKKLVSTPIDPDGDPDVGPNAGPPYDFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1B1</accession>
    <name>A0A6P8I1B1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116297460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031561543.1">
        <property type="nucleotide sequence ID" value="XM_031705683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1B1"/>
    <dbReference type="FunCoup" id="A0A6P8I1B1">
        <property type="interactions" value="1486"/>
    </dbReference>
    <dbReference type="GeneID" id="116297460"/>
    <dbReference type="KEGG" id="aten:116297460"/>
    <dbReference type="InParanoid" id="A0A6P8I1B1"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01410">
        <property type="entry name" value="SIRT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000029">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031561543.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42846" checksum="4593C231B471D708" modified="2020-12-02" version="1">MSVNYASGLSDYPNKGKCGLPERFDSSDDLDSKVSLLVDLLRTSKHAIVHTGAGISTSSGIPDFRGPNGVWTLEEKGLAPNFDVSFDSAAPSLTHMALIKLEEVGLVKYIVSQNVDGLHLKSGFPRSKLSELHGNMFVDKCDKCGKEYIRKTATTSVGQKRTGKSCVQQRRRGTCRGKLCDTILDWEANLPYDDLLAAEQQSRQSDLSLCLGTSLQILPSGNLPLITKKNGGKIVIVNLQKTKHDKKADLKINYYVDEVMKRVMKMLGLEIPAYKGFHPENDPRLCNSVLKTEDSDEESSEDEIEDKSTVKLEDRGTSKLEKTKNSQSNGEHITEFMEGSTQKLENLKREPLNDAEKFSLDIDKGGQNDKEDSISDVKRQKLDVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2S4</accession>
    <name>A0A6P8I2S4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC116295475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559150.1">
        <property type="nucleotide sequence ID" value="XM_031703290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2S4"/>
    <dbReference type="GeneID" id="116295475"/>
    <dbReference type="KEGG" id="aten:116295475"/>
    <dbReference type="InParanoid" id="A0A6P8I2S4"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043544">
        <property type="entry name" value="SNX10/11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46209">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46209:SF3">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559150.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45655" checksum="BD00DB24A6A99EC7" modified="2020-12-02" version="1">MDNDELISVEVRNPRTHLKRRWTSFTDYEIVISTNSMAFALQQSKVRRRFSEFEWLRRTLAKNSSISTTPPPLPNKRVLGRFNQDFLEKRRAALEEFLTKVINTTFHLSELAVHLFLQSSLTTKEIERVLEGKDQRDVAELILQEKKLNEKLTRKGSEHTNTDSGFSGSNNLDWHIPDCILKCQGIGNGWSSGCTNMLGSSSGKRKPCKACRRKSLRNNAASVLPTGQLLIAEDVQDSASKNDSNGSISSSERCPEENCTKCNQYDADDETDANVVDYDIINTKTFRLRDWLTNVTPANDCELDSTDEGDCNLPPSLSRSIPEYDVISVPCSSTSINNTSLRRSNNLSDDGTCGYGSSNDSQYSVVHSTIDGLKLENYNKFMCSSSSTLSSAGIYRTYDVVEMIELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I356</accession>
    <name>A0A6P8I356_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116295601</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116295601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559332.1">
        <property type="nucleotide sequence ID" value="XM_031703472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I356"/>
    <dbReference type="GeneID" id="116295601"/>
    <dbReference type="KEGG" id="aten:116295601"/>
    <dbReference type="InParanoid" id="A0A6P8I356"/>
    <dbReference type="OrthoDB" id="5988859at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF69">
        <property type="entry name" value="MAB-21-LIKE HHH_H2TH-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="4">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="5">
        <location>
            <begin position="340"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031559332.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="54393" checksum="4FC215833A482366" modified="2020-12-02" version="1">MDFSSGLLWSELNDILMSTFDDELGNTASEEKVYTQVVQSLINYVEENVNASDSILISGSFAETTNMHPYVRQHEAEFDIMIATRHFIISRDMQPAIFKDIPDEPGFVRVEASDIRENESIEVKEVIHSGGRSSHFYIVPNRKMFQYQPNPIYKNILVQSMCDTLGIEKLSVMEYQQGPALTGSFLSLLPSIESISTHPKNTLFKFLGHLGTRVLEHFDHDKTETEKNNLNGEFKEHSFWEAFNVMKTTHPKEIPWINKLVVDFCPAIKCEGWPHKALRFFHRTRVWPDHTMLNKLLQSGFHLVYKPLNPLSQDSVEWRISFSQTEVSLFQSMDDFRVCCYRIFKAIYYSELTLPKVLCSYHMKTIFLWACERIPSEMWVKANLAQIIMGLLDDLLHCLVTKSCPHYFIPENNLFAHVHQDFLDHLAKVVAKIRRNPKRYLSVLKNRNTAVQDKDVGVEDVSSMGDIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3Q1</accession>
    <name>A0A6P8I3Q1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116298777</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasmic vesicle</location>
            <location evidence="1 12">COPI-coated vesicle membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="12">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563189.1">
        <property type="nucleotide sequence ID" value="XM_031707329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3Q1"/>
    <dbReference type="FunCoup" id="A0A6P8I3Q1">
        <property type="interactions" value="2194"/>
    </dbReference>
    <dbReference type="GeneID" id="116298777"/>
    <dbReference type="KEGG" id="aten:116298777"/>
    <dbReference type="InParanoid" id="A0A6P8I3Q1"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000008">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="319"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="593"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="868"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="927"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031563189.1"/>
        </source>
    </evidence>
    <sequence length="966" mass="109246" checksum="4B1B0A2C3A302678" modified="2020-12-02" version="1">MPLRLDIKRKLSARSDRVKSVDLHPTEPWMLASLYNGNVHIWNFESQTLIKTFEVTDLPVRVSRFVPRKNWVLTGSDDMMLRVFNYNTLEKVHGFEAHSDYLRCIAVHPTQPYALTSSDDMLIKLWDWDKKWQCTQVFEGHTHYVMHIVINPKDNNQFASASLDRTIKVWQLGSPTPNFTLEGHEKGVNTVDYFHGGEKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNISCVGFHPELPIILTGSEDGTVRVWHANTYRLESTLNYGLERVWAIAMMKGSNNVALGYDEGSMLIKLGREEPAMSMDTNGKIIFAKHSEIQQANLKNLTDDDIKDGERLSLSIKDMGSCEIFPQTISHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFVWASDSSEYGIRDGNKIKIFKNFKEKRSFKPEYGAEGIFGGYLLGVRSAGGLSFYNWENNEMLRRIEIHPKNIFWSDSGELCCISTEESFFILKYNADNVAKALETREDITEDGIEDAFDVQGEIEEVVKTGVWVGDCFIYTNSVNRLNYYVGGEIVTIAHLDRPMYLLGYIPKDSKLYLADKDMTVVSYSLLLSVLEYQTAVMREDFDTAKQVLPTIPRDQRNRVAHFLEKQGFKQQALAVSCDPEHRFELAVHLGELRTAYEIAVESESERKWKQLAELAISKCQIQLAQECLHHAQDFGGLLLLATSSGDADMISRLAITAAKKGKNNVAFLAYFVLGRVEECLDLLCSTDRYPEAAFMARTYAPSHVSRIVKLWKEDLEKVNKKAAESLADPSEYENLFPEFQEAVMAEKFLKQERMSLKPAMQYKNVPNNCERDVFQEIKAAQENGTFDALVSAADGLRIADLEEEMNNVDTQPPIFSVPPEPTQPRPAPPPQAAPLVAEPAPEPPSPSSSNEVNLPSSTNKPLPTDDKDDDDDLDFEDAAGDNQFDDDDFNFDDDDLMDDDDLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I532</accession>
    <name>A0A6P8I532_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296056</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559870.1">
        <property type="nucleotide sequence ID" value="XM_031704010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I532"/>
    <dbReference type="GeneID" id="116296056"/>
    <dbReference type="KEGG" id="aten:116296056"/>
    <dbReference type="InParanoid" id="A0A6P8I532"/>
    <dbReference type="OrthoDB" id="5988734at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559870.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53140" checksum="A127752D3B1F6DFC" modified="2020-12-02" version="1">MGFRDSLRSRPSFALPPTQFTLRCDSSLQGWGSVIEGSDNPTGGRWSPFEATYHINYLELKAIQMGLMSLCNDLYEVHIKVLSDNQTAVAYIRNMGGTHSPSCNLITREILLWCKQRKITITISHLPGHLNVQADKASREFKDDIEWSLDTGVFTMLSRKWGQPQIDMFASRLNHKISLYVSWKPDPMFDRKSPTENSNESNLSNNRGSKVGDTILVPIVVENVGTASNSDTCTSVHFDIGPRSIESTSIIPQIETTWVSCVRKMLQEQGINGQSLEIILDSWRKGTKKQYSTYITQWASYCRQNKVSLTKPSLPQVLGFLAAQSARLGYSAVASTRSALSSFIKLDGVNLGEHPLVSRFMTGLFNRKPALPRYVETWNPQIVLDNIRSLPDNSLLSLKQLTMKLTVLMALVTAQRTQTLKALSLDGIVCSEDQYSFTVLDVLKQTSRHGGQNRHLAPVVFKKFPNDTKLCPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5R4</accession>
    <name>A0A6P8I5R4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299395</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031563909.1">
        <property type="nucleotide sequence ID" value="XM_031708049.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I5R4">
        <property type="interactions" value="2726"/>
    </dbReference>
    <dbReference type="GeneID" id="116299395"/>
    <dbReference type="KEGG" id="aten:116299395"/>
    <dbReference type="InParanoid" id="A0A6P8I5R4"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000006">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028085983" description="procollagen-proline 4-dioxygenase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="423"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563909.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="63037" checksum="3E6A1D0FD35EA6AA" modified="2020-12-02" version="1">MVVASRTLSFLLLFLSLEIAKCEFFTALIDLEHLVYREKELKSSLKSYIAMEEQRLAILKKFSEKVENIHNKIDDKNIESFTGHPVNSYLIIKRFYTDWTKMEELIQKDNSEEMMETIEKHKSAYSSKEDFEGAITALLRLQDTYRLLTTSMAEGKLKNAQPMPPMTVDDCYQIGRYAYLTNDMFSTKVWMEEVLRKIRMNEPPEDVTVFDVADHLAYAEYQRGNLRKALNYTLEMVRIDPHHERALDNVAFFGEKIKKTKPTGLRGERGTVPTTTTTTSXKETFKRIKERDVFHRTKAFQNYEKLCRGEIRNLTKWEESKMKCWFVNNDPLTILKPARIERVFVNPEIFIIRDVLSDSEIDHIKKLATPRLRRATIQNPVTGNLEFAKYRISKSGWIKDDEDELVKRISRRVQAITGLNMTTAEELQVVNYGIGGHYEPHFDFARDGEDKFTSLGTGNRIATFLAYLSNVQSGGGTVFTRVGTVVWPTKGDAAFWYNLKRNGDGDDSTRHAACPVLIGSKWVANKWIHEVGQEFRRKCSLNPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6J1</accession>
    <name>A0A6P8I6J1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LOW QUALITY PROTEIN: uncharacterized protein LOC116296453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116296453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560330.1">
        <property type="nucleotide sequence ID" value="XM_031704470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296453"/>
    <dbReference type="KEGG" id="aten:116296453"/>
    <dbReference type="InParanoid" id="A0A6P8I6J1"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050179">
        <property type="entry name" value="Trans_hexapeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43300:SF10">
        <property type="entry name" value="2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43300">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031560330.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27262" checksum="BCA265180A3A2674" modified="2020-12-02" version="1">LDTHVTLDTHATLDTHATLDTHATLDTHVTLNTNATLDTHVTLDTHATFDTHATLATHATLATNATPMQHLSHMQHLTPMDVTGNQIREIHPGTFSVSLPLIYFNTHATLDTHATLDILLTLDTHATLINTHATLATHATLATHATLDTHVKLDTHATLDPNATLDTHVTLETHATLETHVTLETHATLDTLCNNXHPCDTXHPVTFDTHVTLDTHVTLDTHVTLDTHATLDTHATLDTHATPMQHLTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7J6</accession>
    <name>A0A6P8I7J6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116299961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564554.1">
        <property type="nucleotide sequence ID" value="XM_031708694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7J6"/>
    <dbReference type="FunCoup" id="A0A6P8I7J6">
        <property type="interactions" value="2085"/>
    </dbReference>
    <dbReference type="GeneID" id="116299961"/>
    <dbReference type="KEGG" id="aten:116299961"/>
    <dbReference type="InParanoid" id="A0A6P8I7J6"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="13">
        <location>
            <begin position="312"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031564554.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53503" checksum="1CBD26AF8830323A" modified="2020-12-02" version="1">MAQASISRYFCQSCGYVSRCHGVVVPRGSSSRSCGGRSWMNIALIEKHHNQQVRNFAYRRPDEQPGLFGRFIQNIKEGFERNKEMQENIKKFKKQAEKFEKSDTLKTAKSRFELLDKAKDKFSDASTKISSTARSVSGSAATKVTQAYEEFTKSDTFKKGREASEELSKSAQDAASKIKEQSDELSKTAPFKTVSTGFKVVKEEVLDEEFKQSRPYQTPAELRRRTEASKREGMEKERRLEADEDTTGMVLHKDSKWYQQWQEFKDNNPVVNGLFSLKMKYDESDNLFVRATRVVTDKVGDIFSDVFSQSEMAKTLSEITKIDPQFNKDKFLQECEFEIIPAVLEAFLKGNLELLKDWCHEPAYNVLSAQIEQIKQVGQKLDAKLLDIRDVDLAMAKIMEQGPVLVLTFNAQQIMVLRDATGTIIEGGEDNIESVSYVWALCRDQSILEHRQAWRVLEFGIQNSTAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8R5</accession>
    <name>A0A6P8I8R5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glutamyl aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC116299877</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="29">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.</text>
            <dbReference type="EC" id="3.4.11.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.7" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031564453.1">
        <property type="nucleotide sequence ID" value="XM_031708593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299877"/>
    <dbReference type="KEGG" id="aten:116299877"/>
    <dbReference type="InParanoid" id="A0A6P8I8R5"/>
    <dbReference type="OrthoDB" id="5953999at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004230">
        <property type="term" value="F:glutamyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000023">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 21" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="27">
        <location>
            <begin position="132"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="25">
        <location>
            <begin position="350"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="26">
        <location>
            <begin position="654"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="22">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_031564453.1"/>
        </source>
    </evidence>
    <sequence length="1005" mass="114815" checksum="8D6E2BB50DA30E37" modified="2020-12-02" version="1">MRNVNEEVPLEPKGDKSAETYVVNKGPKGGYIFTKLKLLLLLLLLIILIIIIIILAALLGAERTKNGAKEKVKTTFFPTSLFRELLHSSGDLNSPGGSVAKEKGPGNLTTPAPSSASPTGVWSNTRLPDYIVPTHYDLHMLVDPNNDGFSGSEEIVINVIKKTPTVLLHSNGLDVTEVKIENSNKDVSTIKKHFDFPKNHYHVIETAEPLVPGTYVLELKFKGTYSKSLFGLFKGTYRSKDNKEASFVSMQFEPLDARKMFPCFDEPAMKATFSVDITHPIDMMALSNNIAKEKKDKGSTRTTFFDKTPVMQTYLVSIAVGHFESKEITSKNGVKIRAFAQPGKTDQMDFALKMANETLTQLEEVFGIPYSMTKLDLVAPPECYIAMENWGSIRFEEDGLLYKKGFSSEEIQQDLLMRWLPHEIAHMWFGNLVTMRWWDDLWLNEALADYFNYFDGSPSSVSXWNRDKLFLHSNVGDALFLDGLVNTRAVITSVPQPTIDTFDDIVYKKGSSLLNMLKHTFPSVNRKNFIAGMQKYLKQHSYSNAVGDDMWSALQSTCSVXECENIKEIMDPWMKKAGYPVLTIKKSSTAANKYTVTQEHFLYDITAKQQDTLWSIHFTYSLSTSKSNNKPATIKSKWIKGKKQVDIEWAGNGWIKANMDLTGFYRVNYDDDVWTNLAEQLQHNHFANYNILWKEQGQRLNVNKALDMTNYMIKENDYLPWKCVQKNIGYIQSILPPHSHTYHHLKRYMAFQSEKLFNDLGVQDSGEHLDKLKRLIVTGFQCDLGTKKCLGNLTRMFNEWKKDPLTTSVTPALRKLVYYYGVNQGIPEDWERVLQELMKTSVPSEIQPLLMGLAGSRDTWTLYKYMKMAGNQTIVKRQYAKYVLHYVANHNPDGPDVAWTFLQLNWQDIKQNGGPIQAMMTYIPTITRRLSTSYQLEQLTNFINKNLNREAMPRGLRKAVEIVKLNIAWRAAHEPDLERWLKNFLAKQNLPVQKFRPFDGFSEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I945</accession>
    <name>A0A6P8I945_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adhesion G protein-coupled receptor L2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561175.1">
        <property type="nucleotide sequence ID" value="XM_031705315.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297150"/>
    <dbReference type="KEGG" id="aten:116297150"/>
    <dbReference type="InParanoid" id="A0A6P8I945"/>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="11"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561175.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="64698" checksum="D057BDC7C7B7237D" modified="2020-12-02" version="1">MIMNGKPSYVLHATAIVGCGISLFFCVVSIIGFSCFRPRTESMLIKKHLTMAVCATQTIFLVAIQGYKEEIGCRILSVLLHLAATACFTWCALDALGLYFFHVNSFXPIRNTKLYLLVGWGIPCMVLILTLTVGLVDVESTITYNLSLYSCWASDAIVWTFVVPSILAVVADIIILCTIMKQLRYPSYDISPKAVIEKRGTRYGLRTNSLMLLGLCIGWIFGILSLRDTNNLRYQLIFGLVNGLQGIFLFFFHCLLNTDHVKGYISTSGRTTSTEDEGRSTASDVSRTKKQDQQTSTKRKGRQRASKLENVPLISLNSGPSKQEEESAVNLSKTLAVESCSTSVDIVSEPLDDRKQHLRSGDHDVITHLPGTPDHDVIPQLPGTPDHDVIPQIPGTPDHAADEKACTSQDQFKRKAKKDDRVSATRPKTADNKLQVCEEANQEKRRKSNSEPVISSSYEDNKGQERTERLKANERSSVQFHYSKQKRSARPQRPHSSVNELESLFSRTDFTPTKPHRSSSSSLHSSKASRDRKTSQEEKQRKRFSSTDNHDSDQSSNTNEALEESQSRTPSRSTQQTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9T4</accession>
    <name>A0A6P8I9T4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297769 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561917.1">
        <property type="nucleotide sequence ID" value="XM_031706057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9T4"/>
    <dbReference type="GeneID" id="116297769"/>
    <dbReference type="KEGG" id="aten:116297769"/>
    <dbReference type="InParanoid" id="A0A6P8I9T4"/>
    <dbReference type="OrthoDB" id="5945667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025562">
        <property type="entry name" value="Tae4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14113">
        <property type="entry name" value="Tae4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028400253" evidence="1">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561917.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19683" checksum="DEF5EF7A7BE6C909" modified="2020-12-02" version="1">MFVKILTLLTAVRMASGGVWPSFSTLWNNYPTASQYKGDDLIDKIGLPEWLHGANTCAIRLSYALIQSGHTIDIKENEFNWSGVRASRGGNEKYIIRVATFRQYLENRKGPADVVSKSKADFLGKKGIIVFQNCPSFKTATGHVDVFDGQDCKGQAYFNECFDIRLFELSDRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAJ7</accession>
    <name>A0A6P8IAJ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein of 104 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031562247.1">
        <property type="nucleotide sequence ID" value="XM_031706387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAJ7"/>
    <dbReference type="GeneID" id="116298046"/>
    <dbReference type="KEGG" id="aten:116298046"/>
    <dbReference type="InParanoid" id="A0A6P8IAJ7"/>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048738">
        <property type="entry name" value="CEP104_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21039">
        <property type="entry name" value="CEP104_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 Zn finger" evidence="2">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562247.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18645" checksum="4A65E2BB5E8A2594" modified="2020-12-02" version="1">MDRMCIFCGEQNETFTEEMLDLHYWKNCPMLKRCDHCSQVVEVSGFNEHLVTECDAKDKFSQCPRCKDVVLTVDLEEHITDNTCAAPKGGKDASVCPLCRTVVGPEEEAWRSHLMENCKTNKVRLQQQQASKAPSRASLRSNRGRGGKTTPSTRGIGRGRQGTLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBE4</accession>
    <name>A0A6P8IBE4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116297920 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562105.1">
        <property type="nucleotide sequence ID" value="XM_031706245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBE4"/>
    <dbReference type="GeneID" id="116297920"/>
    <dbReference type="KEGG" id="aten:116297920"/>
    <dbReference type="InParanoid" id="A0A6P8IBE4"/>
    <dbReference type="OrthoDB" id="190994at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="MODULATOR OF FTSH PROTEASE HFLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911:SF2">
        <property type="entry name" value="PROHIBITIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="34"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562105.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33863" checksum="CB8CD2F23BD48E97" modified="2020-12-02" version="1">MAGENRKDKKTLIIILVLAVLGSIIALVVNSLKRIDTWEVGISYDVHQKKLGDKIQTAGLHMGTPGFQFIKFPSVFKTIKFNKITCFNKEGVSIVIHEQFQYRARPKNLRDIIIRYKNHETYAKLLRSLALAAIHDSCSAFNVTQFQTQRAVFQEYVRTLTAQRFNNVSADLTDLQVSSIVRPASYETAVRNMESAEENIKLAKAQRPRLLITANTAKQEAITAAQITKQKADAEASVILAQADATAAGITSTFEAEATAYEAVLTNQNLTIEGLLSYMAVRAVAEKGKVSVNLKEPARTKYTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBG4</accession>
    <name>A0A6P8IBG4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116300017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031564636.1">
        <property type="nucleotide sequence ID" value="XM_031708776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300017"/>
    <dbReference type="KEGG" id="aten:116300017"/>
    <dbReference type="InParanoid" id="A0A6P8IBG4"/>
    <dbReference type="OrthoDB" id="5988573at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031564636.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43209" checksum="E665379980C9A2A2" modified="2020-12-02" version="1">MAFIRCFGRITLRKKAVLGTIFSIWIVVLVLQKFWELKLEMEDSYQDRQATLNNRRMNQSYLPIKDPVITPNGFNNSQFLXIILVSSSPSNLHRRTAIRXTWGRAENWNFFGTMPLVLRKXSYRTAFVIGTSSSLXLEIXEEIAKNHDMLIGNFTDSYKSLNIKVFMXXXWSLSIXCKXILKADDDVYVNVPLLSTWLNNKNSKIPKDLYSGFVHWSIGPFRKNNSKHFLNNILYSSKVFPPYCAGFSYILSRYLVSRILDASRVILPLWIDDVYIGMLVYYLGVRPLNHDGFHLRLNAVSSXELHGFNECSFLNTFTYGHQMGPKELIHVHETFRRMDSRSNGYLVFQCMSKNLAFTMSVVVPSLLLSITAIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBQ2</accession>
    <name>A0A6P8IBQ2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116300137</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031564781.1">
        <property type="nucleotide sequence ID" value="XM_031708921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBQ2"/>
    <dbReference type="GeneID" id="116300137"/>
    <dbReference type="KEGG" id="aten:116300137"/>
    <dbReference type="InParanoid" id="A0A6P8IBQ2"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    <sequence length="1027" mass="114148" checksum="90F6AF311FDE8635" modified="2020-12-02" version="1">MANSGFLQVVFGLLWVTLFLKAFSDATASPKFTTKPNNPLVGFQGEAVNFTWEFSNHSISKVYFGVYKRDWGTLGNTLIWIASHKNGSVDVTVAKNEPDVKPYIGRMRWVGDLSQNKAAFELSPLLSTDKKFYGIEVEFGPTTLSGFTELDVKMLSNFTLGAGTLSVQRGQRATFAWRYDLNKDDIQTLSSITFGVYKNGEYKALCLIKVKGKYVESTNCSTGIRNPDAHHTVLESTKQATFVLSAINLDDEAVYSIRLGGTLRNMENKILLIVTDPPKITQPPKSTTIIEGKTLNLTCAANGKPRPVITWLKDSQVVQENYTEQYVIRSTERKDDGKYYCVAENEVGKVTSGIATVDVQYAPIINISSHLQIVRVPIGRGVLLRCPVSANPEAKIEWLANGILEKRDTDELYIFISNSFDYANYTCKASNSIGKDYVTFVLQQVGPPSVPRVDCEKREDSRVSRVAIFHWLEPKDDGGAPVLVYTVKHRILKNNFMRGAWSNENVTNTRTWYKFNLQWQTTFEFSVTAWNIYGESKLDPDNSCIVTIGKEPKTEEEGSTLNPQATKQVVAAAARKGDTGSSSSASVLVYVGPIIALVVIVAVVAVLIHRRRRKRGKRGKREWNDPRHFSFGEALSLEGNVWGEASANDNLLGSRSRTQSMVGSPCYQMDPDWTIPREKICILKVIGNGAFGLVYKGRVHGKGPNSVGWNLVAIKSPYADATDAEIRDLMKEFELLKTLKPHPHVIRLLGCGEDEGRPLVVIEYVPFGDLLGYLRKSRGENDDYYSDPEIKPNTNLSSQQLLRFGWHVADGMAYLASEKIIHRDLAARNVLVGEGLSCKVTDFGMAKDVSNDDIYVRTTEGRLPVKWTAIEALTGSGEYTTKSDVWSFGVVLYEICTIGAEPYAGLNGKEIPQRLDDGYRMPRPGHVDPELYDVMTSCWESNPDDRPTFPELKETLIKLEEVQTRDYINLSECLYQNVKANGQVRLPKRKSFLGSIGKASGSSKEAAKGNAYHMGPEISASNVGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <begin position="119"/>
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    </feature>
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            <end position="150"/>
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            <begin position="188"/>
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        </location>
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    <sequence length="305" mass="34420" checksum="2A3F82345590DEAA" modified="2020-12-02" version="1">MANRLSATKIRLPPIDSSIHDLVTGLPIKSRNSEKRRNVLDRKKGIQDHSVIDFPPIVQPPSLQQFGSYERRKPLRNASVKMTHIEKIPTQFPGKKFAVLPPIGGSQCQEQKNKRSDENPSVQPCGTIQESVVKRRATKKAESTDSRDSNELNPNSAVNKSKQVLKRQISVLGLANIDRKQGYKVVNNGPSDESQTLSTSKKKPFDKSSLNSLTNAEIFQPRSDLQDDDNVIDDDDDDDDSTMMKLSEVLQFLEWSSELREFLNGKNSSRRNATCTGIDPMLTHAVDVIRDMLLRQTMEELCMMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICC7</accession>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22426:SF1">
        <property type="entry name" value="LYSINE-RICH NUCLEOLAR PROTEIN 1"/>
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        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Small acidic protein-like" evidence="2">
        <location>
            <begin position="283"/>
            <end position="360"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
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        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563342.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44599" checksum="4EC9CEFF869BE821" modified="2020-12-02" version="1">MEERKNKNSKKKNKKESAKDVDINEDRGNSKEEEEGMLDQDLKPKKKKHKRNKESNSDEDEIELGKKKKKKIEKKSEKEKTVPEDLEDNFSSDIESMTKKKRKKEKKGKEEVESGKDLTKRKEKKKDKTRHEQEVTSSDSDSTTKKKKKTKSEDKESIYDDINNAKKDKGKKKSKSKESQDNSEEDDSEHKSDVKKSKKRKHKSKDDSEEKSSDSETEDQPKKKKKRKKEKEHRNEKNHKTDETEKKKEKKKKAKDKDQTDDGDESQQTEQDLAAGTRQFNSWENASFESDXRKEKFLRLMGGFKKSSNKDGSALNQTSQPKSSFSAMSRSQESSFNKALEDQFQKAFDLKRTSRGRGLGYDGNLDPENKTFFIDKQPKSTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICU8</accession>
    <name>A0A6P8ICU8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcriptional enhancer factor TEF-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562965.1">
        <property type="nucleotide sequence ID" value="XM_031707105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICU8"/>
    <dbReference type="FunCoup" id="A0A6P8ICU8">
        <property type="interactions" value="2052"/>
    </dbReference>
    <dbReference type="GeneID" id="116298588"/>
    <dbReference type="KEGG" id="aten:116298588"/>
    <dbReference type="InParanoid" id="A0A6P8ICU8"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000001">
        <property type="entry name" value="Transcriptional enhancer factor TEF-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016361">
        <property type="entry name" value="TEF_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002603">
        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="9">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562965.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50888" checksum="4AAED5484BD9B500" modified="2020-12-02" version="1">MTNSADEGKAKSPADMANDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHLQVLARKKVSSHIQVLARKTAKDIQGKFKDQAARDKALQTMASMSSAQIVSASVIHNKNTSGGASGFSGNDNQSYQYWQQPGSNQQAAGYGSVNQSPYGSPIQPGMQAGSVVSTATAASSAGAVVNSQDEIVRSTTYGDTRTVVTSPPTGHASWNSNRQASHMPLRLLEFSAFLEQQTMDPETYHKHLFVHLGPNTNFTDPLLEAVDIRQIYDKFPEKKGGLKELYDKGPQPVFFLVKFWADLNTSIHDEAGAFYGVSSTYESSENMTITCSTKVCSFGKQVVEKVETEYGHFENGSFLYRIHRSPMCEYMINFIHKLKQLPEKYMMNSVLENFTILQVVTNRETQETLLCLAYVFEVSTSEHGAQHHIYRLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEG2</accession>
    <name>A0A6P8IEG2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116300495</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565232.1">
        <property type="nucleotide sequence ID" value="XM_031709372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300495"/>
    <dbReference type="KEGG" id="aten:116300495"/>
    <dbReference type="InParanoid" id="A0A6P8IEG2"/>
    <dbReference type="OrthoDB" id="5990645at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027878261" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="105"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="434"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="679"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="923"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="1539"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="1908"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1437"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1782"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1977"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1323"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1437"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1791"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1804"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1824"/>
            <end position="1834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565232.1"/>
        </source>
    </evidence>
    <sequence length="1997" mass="202497" checksum="77D2659E5C4552B4" modified="2020-12-02" version="1">MRSLFLELVVVTLFCLASTKARILPKGKPQSRFYIERIGLEPKESNERHSQRETLYRGAAKSPKKKTNEKKNHNDGMKLEKPGLKIARVNNDDDSKSKACDAKVDLGFLIDGSASLEMYGKGTFQKCLDFIKTVLKTFDVGEDGTRVGAITFSDNSTVDFDFGQYNDKDELNDAIDKITHAGLTTFTGKALKLAMDKLFISARKGVPKILVVMTDGRSHDDIVKPSQVLKKDGVQIVTVGLGKNYDLNQLKAISSKPESKHLITVDFSELLAASDTLRDIICKAADSPPKSIVKSSSLNEQNSIKSQVKYPEGERGTGKDIPNSIVDYLKSHLTANGEAQRRGVGAQFTSRTVSSGGSYSVSSSSKTSSSQSSGGSSGGSVSGGGGGGASAAGGGGSAGGGSAGGGAAGSGAAGGGSDSGGSASASSSGGGKCELAFMLDISESIQSEANLQLCITFIKAVFMSFSAGLGSVVRFGFVTFSASATVVFDFAKYTSASQIEGAFGSIKLAGGSCAAGAALTTCKSSLFASARSGAAMVLVVMIAGKSTDDVSAGAGALKGMKVKTIAVGMGAKFEQAQLTAMAWEASYVITASSFSQLTSIQGQVTSLVSSAGGISASGGAGGSAGGGAGGGAGGGAGGGAGGGAGGGAGGGAGGGAGGGAGGGAGGGAGGGGSVSGSCDLAFMLDTSTSIGGEAXFQLTLTFIIAVFEAIGVSAQIRFAFIRFGSSAEIMFSFSKYSSIAEIRTSVMGTKMVGGECKAGVALSAAREMYSGARKEVSRILIVMLAGSSADSIDAGASGLKESGVKIIGIGMGGSYSKEQLGIMISSSSYMLVAASYSSLSGLSGQCVQLVIQASGGGLTGGAGGAGGGAGGGVGGGAGGGAGGGAGGGAGGGAGGGAGGGAGGETGGGSGGGAGGGAGGSGCDVAILLDSSTSIEGDANFQLALAFVVAVFEAIGVSAQMRVAFIIFGSSTQVVFNFEKYTAFADVRTAVMGAKMVGGTCTAGAALTTCKTDVFANARSSRILVVMFAGRSTDSVMAPSSAIKEIGVKIIGVAMGGGYDQEQIDIMASAQEYILKAASYSALSGLSGQCVELIRKVGGCGAGGGGGGAGIGGGGGAGIGGGGGGSIGGGGGSSIGGGGETKTATEEIAQNIAKEPGQKEMINELKEKGLLNKQGEEVVNKEKEIEGKATDENKQEVLKNLEKQNMLNNEGKELLKQENQKVLLEELGKNGLLNKEAEETIMKEGENGFMKKLGHTTTEVGEGTLPGMTVDSSGKVVSSGGTIPGQPGVTTTLSGTAVDSSGKVVSSGGTIPGQPGVTTGGTLPGTAVDSSGKVVSSGGTIPGQSGVTTGGTLPGMAVDSSGKVVSSGVTIPGQPGVTTVGTLPGTSVDTTGISQPGASVVQELQKTPSGQAIMTSLQNQGLLSPDGQNVLSRVQTNEFGVSPGGQASMTSIKGSPEGQQLLSSLQSQGLLSPQGQMNLAVSQGQGQMVPSQGQVVQSSIGYGTGIRISGGGGIGIGGGGGGGANIGISGGTSGMHVCMDLAFLIDGSMAVGGEGNFKQILNFVWNVVQSFSVGAHLTRVGVVLFSLESFAIFNFHTYYDKSNILQALNTVQYPGTDGPGTYIGRGLHVTRHYLFEETGRPRVPHALIVVAAGRSLDDVISPAMELRSLGIDIYCVGVGSSYSKLQLHAMASFPHSEHIFGASTTQLGYIAQNVVTKILKGISVHFCHPCFEGQTDMCDYCPDEFHSDIFRREHYHGSKLPMAKPAKLEADNPDFIKKPLLSTNLNTEADPEESKDPFNDDPSHSNDSLNLSESSETDDSDDTKAQGSHSSSTIEGNHLQVHHELPRFHSDELKGADDGINWKTNYNDMDMAQDDSSNRFFNDNLKEEEKNYSEYKYDASHVSVDTEECKDYADECEQYALQGYCSEYAPTTGIGTINMMCKRSCGTCHSTSSDDDGQYTYKVTQSLDTNYFKKGQVEKDRKTKQNNTKNLRKRMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF52</accession>
    <name>A0A6P8IF52_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">D(2) dopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565300.1">
        <property type="nucleotide sequence ID" value="XM_031709440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IF52"/>
    <dbReference type="FunCoup" id="A0A6P8IF52">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="GeneID" id="116300553"/>
    <dbReference type="KEGG" id="aten:116300553"/>
    <dbReference type="InParanoid" id="A0A6P8IF52"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000437">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565300.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39063" checksum="29D67A8A780D8B1F" modified="2020-12-02" version="1">MAESVGFVFHVLFLVLLMIVIICGNSLVIIAFKTNKRLRTATYTFLVSLAVSDFLVGSVSLPLWVYHLKYYPSSVEVGLTNFYACFDIFSALASIFHLTGVTLERWIAICKPFYYNTLSKRSYHISILIAWFLALAVAAPYPKIYIPKENLFIAFKAYSVIIFLMGLVIPSVLITFVNLSIFKVVKSLVKTTRQQLDQSSDRVLDRNIFRDRKTAMTLVLITTLFCVSWTPFFLINLVPIYCGHCFSPMLGNVKFVSCVKWLHYSNSAYNPVVYAFRDAEMRMTFVRLFKRCGRVLKSRQKPKSEWELSLNTDFILSPRSVSNYNRRADLSIPLKTKVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF57</accession>
    <name>A0A6P8IF57_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leukocyte receptor cluster member 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565325.1">
        <property type="nucleotide sequence ID" value="XM_031709465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IF57"/>
    <dbReference type="FunCoup" id="A0A6P8IF57">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="GeneID" id="116300580"/>
    <dbReference type="KEGG" id="aten:116300580"/>
    <dbReference type="InParanoid" id="A0A6P8IF57"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565325.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32369" checksum="58E01DE721FA72FD" modified="2020-12-02" version="1">MNILHHKSWHVRNKDNIERVRKDEENARLEEEKKAKRAALADQEARTALLRDRAKGSKSKELTNDSKSSSSPGLDLAPVSISDQQKHINFFEDIEEGLRQGNNPEYEAEKKAEQEKQEKAIGLLTYLGQSASEKHSDKPWYIKKDHQKKATDNDNSRDMKRKDALDPLNKMKKYLEAHEKHKHKKHKKEHKHSKSRKEKRREETSPRKKSVQELRAERLKREQSERIRESELRSSSKGEKKAPEPLEDNPYRYNSQFNPDLVRKPHSSHRYRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG10</accession>
    <name>A0A6P8IG10_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 20-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116300868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565690.1">
        <property type="nucleotide sequence ID" value="XM_031709830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG10"/>
    <dbReference type="FunCoup" id="A0A6P8IG10">
        <property type="interactions" value="2552"/>
    </dbReference>
    <dbReference type="GeneID" id="116300868"/>
    <dbReference type="KEGG" id="aten:116300868"/>
    <dbReference type="InParanoid" id="A0A6P8IG10"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031565690.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="58710" checksum="9611D6BF8698D373" modified="2020-12-02" version="1">MASPKGPGSELKQHFVTKEGVYKLMTLSEYSRPNKMPYSAQQCHPVKVSFVTVKEPGGCNDRIAFNVGRDLYFYIYKGVRKAADLTKPLDKRVYKGTIPTCHDFNLLTRSSESLELLIGFSAGQVQLLDPIRHEVNKLFNEERTVDKTKVTCIKWIPGSENLFLVSHESSNMYVYNKENPAGTGPPQYALMKQGPGYTVHSGKSKTTRNPVCKWTVGEFGINEFSFSPDCKHLAIATQDGCLRVFDFDSQTLYGVMKSYFGGLTCVCWSPDGKYIVTGGEDDLVTVWSFFERRVIARGQGHQSWISVVAFDPYTTSFSGDGRVDESDEEDIEENGPRDSPCHPSADKGVTSYRFGSVGHDTMLLLWDLGEDILRPQRPRCRSLRTHTMSNSHLVNSNSISNGPVCWEPNNGATSNDTSRSLTKVHSLSKSVEQLVTIRDYSPGTSLCPRIVEAPLLEPLVAKKIAYERLTDIVFREDCIVTACQEGFIRTWARPGRSDNGNSSLMEDDEAEVLCNGDHEHPSQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG75</accession>
    <name>A0A6P8IG75_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenosine receptor A2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565752.1">
        <property type="nucleotide sequence ID" value="XM_031709892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG75"/>
    <dbReference type="FunCoup" id="A0A6P8IG75">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="GeneID" id="116300924"/>
    <dbReference type="KEGG" id="aten:116300924"/>
    <dbReference type="InParanoid" id="A0A6P8IG75"/>
    <dbReference type="OrthoDB" id="10329382at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565752.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34222" checksum="B5CFAA01275A7DA5" modified="2020-12-02" version="1">MDQPISLCFVPANNFSNSITSQDARNLLILEVINSVLAVPTAAANALVIVAILTTSSLRTPSYLLLSSLAISDLAVGLLGQPFFTFCIFSFRNGNAKAYCYARWISTVILALLASGTLLTAAAISVDRYLAIRIKTRYRSVVTVRRVRYILISVWLHSIFTLSCPFFMSPSTSCYVAASELVICMLIIMYCYTMSFKVLKIHCAQTHPQGDQQPNSTTQSNTIDVLKYRKLLKTLLLIMVGIFICYLPLASAFVIFTKPNPNRVVAWYLLSITTLNSLFNPVIYMTRMKDLRRVCFQMLRKIFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH02</accession>
    <name>A0A6P8IH02_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing protein 4A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116301230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566117.1">
        <property type="nucleotide sequence ID" value="XM_031710257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH02"/>
    <dbReference type="FunCoup" id="A0A6P8IH02">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="GeneID" id="116301230"/>
    <dbReference type="KEGG" id="aten:116301230"/>
    <dbReference type="InParanoid" id="A0A6P8IH02"/>
    <dbReference type="OrthoDB" id="10003345at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000034">
        <property type="entry name" value="SH2 domain-containing protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388:SF17">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14388">
        <property type="entry name" value="T CELL-SPECIFIC ADAPTER PROTEIN TSAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="563"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031566117.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="82139" checksum="C4273FA9329B2887" modified="2020-12-02" version="1">MLAQILKEMYVDPDLLAELPEEQKQILFVKMREEQVRRYNEWEKELEEQVNNVIKPKKAHAKSVHYLMAKDGNPWVWVMEDDIDLEKIRKEQEMREDQLAEQKAMEQAHKEAEELLRKEQERLEEEERRLKEEQERLEREGAEKEAKMKKLQEEARQLAIKAAEDKKRLEEEKRQAERKKREERRKLEEERKREQEARRKAEEEKAAKAKAEMEERMRKLEERKREAERKAEEKRREHLKELEKKRQEEEMRKLEAQRKEELRKYEEMKKAEELARQKEEEERRLQQEKEDRLRREKEEEERLQREKEEKRRREEEARLKQIEEERRILEEQRKLEEERREKDRQRREELKRLREQRLAEKQKREEELVQQEKRRAQEIYLSLKTVREEDKKKEEEEQKKVDEAWKVSELKAKEAEKERRNSVSLARREVLRERIIAAKRRNTLGKTITIEAPPTPSPTLSTHRGSISMKPNRAPPPVPNHPPPPIPNKPALAKTRSTSPPPRPPPPRRVSLNAATLPIQSGDRPERPQRNRKPRSRVDVIEWFREEEFPKRACYVGDSVLPYFHGIVSRQEAEEILLDKPVGSFLVRVSERVWGYTISYRSQERCKHYLIDTSENTYQFFGHNQIAHPTLNDLIEFHKVRPISGQGQELLQHPCGQARDPPDYEELLKPPDNKEMTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH05</accession>
    <name>A0A6P8IH05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Optineurin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566122.1">
        <property type="nucleotide sequence ID" value="XM_031710262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH05"/>
    <dbReference type="FunCoup" id="A0A6P8IH05">
        <property type="interactions" value="1289"/>
    </dbReference>
    <dbReference type="GeneID" id="116301237"/>
    <dbReference type="KEGG" id="aten:116301237"/>
    <dbReference type="InParanoid" id="A0A6P8IH05"/>
    <dbReference type="OrthoDB" id="5983103at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032419">
        <property type="entry name" value="CC2-LZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034735">
        <property type="entry name" value="NEMO_ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051301">
        <property type="entry name" value="Optineurin/NFkB_EssMod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31553:SF1">
        <property type="entry name" value="NF-KAPPA-B ESSENTIAL MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16516">
        <property type="entry name" value="CC2-LZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18414">
        <property type="entry name" value="zf_C2H2_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51801">
        <property type="entry name" value="ZF_CCHC_NOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="806"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC NOA-type" evidence="11">
        <location>
            <begin position="841"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="769"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="80"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="243"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="580"/>
            <end position="747"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51801"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
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    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566122.1"/>
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    <sequence length="873" mass="102540" checksum="90FF4DD982BC6613" modified="2020-12-02" version="1">MSLTMNAMSTSPKSSLSDTDDFVMVSNSPPPSTSVEVLKESLEQKEYGEQPSSDLLPKAVSEKPKDNEILEKFVALAKENEELRETLKHNNNTLQKHINEFAEMQDQYKQNNETIKKEHQKAKEVVTKLRNENKSLKEQLKSLDIENGEILKKEKELGIEKENAFLRQQINTLKGQISQIDNQIEENQFTEVAVENWHQLLGSIASYEYQTGTLFHGIEKQHESSSEVSSEDISSQKDGYSQLEAVKVDLDKLKDEKDHMEKQLLEMLEINKKLQTRSEHAKEEKEELQKMLNERLEKDAERGNEQQELKEMVHNLNAKVESLNEELQKKTQEMSEAEKENKRLAAECEVRFQKEEELKQKLREMEIEMLKKADEDDSVSKEKFEMIKMQYIKYQGQVDKLENEKKELQDKLKPSEEQKNKLQEELDNVKKLINIQDKEMAEEKLLEFRKLMEEELESRSETYREKLIQLHSELEEGRNREEHNLKQLENLQSEVEEGKRREVMLQERLETFQTTLEEKESMVESLQDQVCHLIEENESFKVKNDKLTEINARRDKLYEGRMKNMEKEGYNREKEMLSLIDMLKTEIGSLKEENKKYLEQRQMSRKEMERLETQYESLLKEYDELFNLYNGTLEESRSKRSDASAEIDTYKRQIDFLSAERSCFEEALHKKDFQIQEMEEDLQELQSCKERVSVLEQQLEVYRNDFQAERESRERQHEEYERVRMENEDLQRELDNLANNQMAEMQRRHGSHVPHHSVIGLVNQQPFRNGFYRRGGEPDPRGGFESGGGRNAPGQGTPDEQSEDPYQCHGCRKNFVRFSELQTHVRECPAALHGNGPPQAGVGNSQPYCPKCGNEFPDLDTLQIHVLECLDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II38</accession>
    <name>A0A6P8II38_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase domain-containing protein 4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116301589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566531.1">
        <property type="nucleotide sequence ID" value="XM_031710671.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A6P8II38"/>
    <dbReference type="FunCoup" id="A0A6P8II38">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="GeneID" id="116301589"/>
    <dbReference type="KEGG" id="aten:116301589"/>
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    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031566531.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28420" checksum="5DD1B0D338E48E21" modified="2020-12-02" version="1">MNLSFAGCGFLGVYHLGVAKCLVEHAPNFLRSIKAFAGASAGSLAAAMLATSAPIDKCSEYVVDLTNEARKNPLGPFSPQFDLVGNLRKGMEEYLPSNCHKLASGRLFISVTSLKTRKNLMISEYESKDELMKVLLASCYIPFYVGLDFPEFKGQKWADGGLTNNLPVLPFGETILISPFSGKDMHISPEDESQGITDITFHNMNIFVNRENLQRELRIFIPPKKEGIEEIVQKGYEDALKFLHKKNLCDHSLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIX6</accession>
    <name>A0A6P8IIX6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZP domain-containing protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116301747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566719.1">
        <property type="nucleotide sequence ID" value="XM_031710859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIX6"/>
    <dbReference type="FunCoup" id="A0A6P8IIX6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="116301747"/>
    <dbReference type="KEGG" id="aten:116301747"/>
    <dbReference type="InParanoid" id="A0A6P8IIX6"/>
    <dbReference type="OrthoDB" id="5977047at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027806660" evidence="6">
        <location>
            <begin position="22"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="156"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="8">
        <location>
            <begin position="329"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031566719.1"/>
        </source>
    </evidence>
    <sequence length="666" mass="74557" checksum="352C9B6E5CC425E7" modified="2020-12-02" version="1">MVASVWLPIFGLLILASFSSAGPLDCGEGNWEVEITGTKPGEIYSPNFPTAYPANRDCTWKIKAPLGNLIRVTITNLNLANGDTLTFSDGETAFPGNRIGQYSNCMDGKLPLFSTGSNMLVHFKSNAAGEDKGFKLTFKIVKKSKVESAGKVERTCSPLSRVSGDSGYIAHQEFPDSLSKQVQCSWEASVPSGKRIFSSFKMFGIGDKKDGYCSDYVLRHNFQGSATAGRYFCGCKLPNNIASTTNVGFYKFATYKNDQIYPGFLAYYKGLDPGTCVDQKSCSQLEDDRNVGFDRNGNILFERKTVTTTPPPTTAPKKVSAPVKPFQVNCKKDEIEIVLNITKYPELQHQSATLSDSSCKASHTNATHVFIRTALDECGTTHNYSSDGRYIIYHNEILIQKKALSKGESSVITRDHEAAFVFECKYHRSVVMSVVHFTPARAKVYTRTENFGNFTYEMEMFKSEKYDEAHDKYPVTVLANQRVYFQTKVVANDTDLVLLVENCKVTPSKDINDKEFYVIIEKGCERDETLKYNHKLSPFQRFSFNAFYFEADREATIHLHCKVRVCRRADKKSRCVEGCPYSKRRRRSEGVESEDISGTLMVGPLEIRDRGASSGRPSSPESRTMIVEVLIGVLGFIVMLLVVAVIFVVVKHQRRPKKLSLIVDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKI4</accession>
    <name>A0A6P8IKI4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Guanine deaminase</fullName>
            <shortName evidence="9">Guanase</shortName>
            <ecNumber evidence="3 9">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116302311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 9"/>
    <dbReference type="RefSeq" id="XP_031567451.1">
        <property type="nucleotide sequence ID" value="XM_031711591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKI4"/>
    <dbReference type="FunCoup" id="A0A6P8IKI4">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="GeneID" id="116302311"/>
    <dbReference type="KEGG" id="aten:116302311"/>
    <dbReference type="InParanoid" id="A0A6P8IKI4"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="70"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567451.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49692" checksum="B911E474122BCBBA" modified="2020-12-02" version="1">MASAKCDKVFCGTFVHSSNENLMQILMNKAIGVDSSGKIIFFDDESRIVDLQEKFSFTTDQVTYLSGREYIIPGFVDTHIHAPQYIFTGTGYDLPLLGWLEKYTFPSEAKFKDVDFAKMAYRKAVERTLKNGTTTASYFATIHYDACTVLCDLVEELGQRAYIGKVCMDRNAPEFYVESTRRSVEDTERFIKYVLAKNDSLITPVITPRFVITCSEELMKGLGQLAQKYQLPIQSHLSENLREIREVNAMHPDSLNYTNLYKEMGLLTEKTYMAHCCHVSLDEVKMLSECKTSVAHCPMSNFDIRSGVADVKLLTDHGIDVGLGTDIAGGHSPSMLSAIHMAIVASNTIQFTRGDDYKPISYKEAFYMATLGGSKVLGLDNVIGNFIVGKQFDALLIDTGAKDSPFDVFEDDSIEDLVQKFLYIGDDRNIKKVFVAGKLVSGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILB9</accession>
    <name>A0A6P8ILB9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tyramine/octopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116302133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567213.1">
        <property type="nucleotide sequence ID" value="XM_031711353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILB9"/>
    <dbReference type="GeneID" id="116302133"/>
    <dbReference type="KEGG" id="aten:116302133"/>
    <dbReference type="InParanoid" id="A0A6P8ILB9"/>
    <dbReference type="OrthoDB" id="5964710at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567213.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30412" checksum="001AC6ED9E808DE7" modified="2020-12-02" version="1">MPIEAAHLYYSPIWPFGKVLCRLWNTFFATFASLSVCTLCAISAERLWALLRPFRYDSSEISVKTLIILVSLWIYAFLSGVYSFFIWDVDEEGFCFSDLSAPFDKAAPILIINVLLPYATCLVAYGKIFKISHKQEKNICLTTVNCSNKINSKRKRIVSHLLVRKSTVTLGLLLGSFTLCCMPFLVFHIIDAAVEHLPNRLYVSSITKWLFFVCSSSNWALYGLLNKDYRKTMMEIVGNMMFFRKNRVAFVQNQELTIRVTISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILI8</accession>
    <name>A0A6P8ILI8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116302388</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567530.1">
        <property type="nucleotide sequence ID" value="XM_031711670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILI8"/>
    <dbReference type="GeneID" id="116302388"/>
    <dbReference type="KEGG" id="aten:116302388"/>
    <dbReference type="InParanoid" id="A0A6P8ILI8"/>
    <dbReference type="OrthoDB" id="10295799at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567530.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18304" checksum="E96716F844E6BA5B" modified="2020-12-02" version="1">MGNSRSASFEVDHPPGEVTPTRHSSRKEFTFVGENDSNNSKPYISTRPPGMYADVYAESLVSENSSKESETISTVSSTSNAVKRPSFADHYTKTAPSRLSISIDNEDGIKTDTQKTRSVNQHPSPESFFDAIFATIEQEAGKRSPVPPRRSPHTMAKKRWTTMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILR0</accession>
    <name>A0A6P8ILR0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC116302696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC116302696</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567904.1">
        <property type="nucleotide sequence ID" value="XM_031712044.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567906.1">
        <property type="nucleotide sequence ID" value="XM_031712046.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567907.1">
        <property type="nucleotide sequence ID" value="XM_031712047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILR0"/>
    <dbReference type="GeneID" id="116302696"/>
    <dbReference type="KEGG" id="aten:116302696"/>
    <dbReference type="OrthoDB" id="10401261at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567907.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="41668" checksum="E8A05811A5112BD6" modified="2020-12-02" version="1">MAVSESTCVSTIMFMLSILLTIGQIITAVVLIILVKAFWNLRRRVLDYEKNLPLVRLETPQRINTTTATKPLKRASTTASSKRLEDGEEATVVPTPNPGNRRSVCEQQVPHADDCTMTVPRTQSTSAQKLLELIHNVSFESFSSPRDSGTGSASTTSPNSSISYELQRSMKESFSKREGSSTLPKTKSWGSQGSKSCDAPFESGRSLSTASCGPSRPTRYGSHFVKFLSKKPINENDFRPSRLKTISIEMIGQDDDDCPNETKSKRASRILREMEEDASEEPAAIEEVGFCNEGYHASSNRSSPEVSKNAPLASEESVSSSNSESVNEINNNDFEKLDSEDEYENQEVVDAMRYNSVGSKKGCSSKQNEPVCVKSSTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM69</accession>
    <name>A0A6P8IM69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-1A adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116302514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567690.1">
        <property type="nucleotide sequence ID" value="XM_031711830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM69"/>
    <dbReference type="FunCoup" id="A0A6P8IM69">
        <property type="interactions" value="1347"/>
    </dbReference>
    <dbReference type="GeneID" id="116302514"/>
    <dbReference type="KEGG" id="aten:116302514"/>
    <dbReference type="InParanoid" id="A0A6P8IM69"/>
    <dbReference type="OrthoDB" id="5958759at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="51"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031567690.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37047" checksum="EF8DE33D1BE95546" modified="2020-12-02" version="1">MTNTSHRNETEDCITRSSSLVSCSPACFFPSVPGYSLVTVTGILAVAGTLANTLVCVTILRNPSLRKRKNYLILNLAFGDLVLTAFGMPIYAVYTLGEMERSCVIIISRLKGFNLNISIVVSLLTLCAISIERLVVIVWPLKYRNIITKQRLCVTIALSWIISSIYGIIIATDVHTHSNLVYKVFTLVSFTGMALCYIIIALCYVIILIKSIRMTYDRRNLAPSHQDNTDRRVALTVALIIGLFTITWIPFVFFRFFAGNHDKLWFKVSELLALSSSAFNSIIYFYRAKEYRAALKHLVRRSPEVHSVSRENYRRTVEKLELTNRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INK2</accession>
    <name>A0A6P8INK2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC116302724</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031567946.1">
        <property type="nucleotide sequence ID" value="XM_031712086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567948.1">
        <property type="nucleotide sequence ID" value="XM_031712088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302724"/>
    <dbReference type="KEGG" id="aten:116302724"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008726">
        <property type="entry name" value="PRK11728.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF2">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031567946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567948.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="50779" checksum="0832B334E61C9096" modified="2020-12-02" version="1">MLSKRLLTTRRGSVLIGNAVRRCKQGEAVTSCDLQKRALNTQSYDIAIVGGGIIGLATARRLIMNYPNLKFCVLEKEKELSTHQTGHNSGVVHCGIYYKPGSLKAKLCVEGLDLTYKYCDENNIPYKKCGKLIVAVENKEIPLLNNLFDRGKMNGVRDLTMVDRKGIKEIEPNCEGLFAIVSPNTGILDWAQVSNSFGENFKXAGGDIYTNYNVTDFTCTTESDKQQEKEEGLAYPVTIHGKGVPLINCKYVITCGGLYSDRLAEKSGCSKVPRIVPFRGDYLVLKPEKCDLVKGNIYPVPDPNFPFLGVHFTPRIDGSVWLGPNAVLAFAREGYKLWDVNLKDLGDAFAFRGLRKLMFKYFSFGVGEYYRGIYTAAQVKQLQKYVPSLTVEDVTRGPSGVRAQALDIEGNLVDDFVFDGGVGEIGSRVLHVRNAPSPAATSSLAIAKMVAXKAKERFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INY5</accession>
    <name>A0A6P8INY5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303184</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568542.1">
        <property type="nucleotide sequence ID" value="XM_031712682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INY5"/>
    <dbReference type="GeneID" id="116303184"/>
    <dbReference type="KEGG" id="aten:116303184"/>
    <dbReference type="InParanoid" id="A0A6P8INY5"/>
    <dbReference type="OrthoDB" id="5958806at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF31">
        <property type="entry name" value="RIBITOL 5-PHOSPHATE TRANSFERASE FKRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568542.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37869" checksum="DF0B1A6D8701CEBB" modified="2020-12-02" version="1">MADYTKAPNSHRDPISNTGIPLPLQLWICNMVEFPFVIRQSVFNRIGLNQSYGEAMLLDFFLRSNGTLKIAVSHRCIFSKSQSIDKQSSGTKRQVNMDYGLLGHNHNILRIVRQDSITWTKCSSNNSSCPDIPEEQNKVDNILLPYCCKTALNQILMHTVDALNQIGTGYRVCFGTLLGAIRSKTIIPWTQDVDICLKSEHFTTQTFEKLKELLLPSNFSLAFLESMHRVVPLNAFVKHLSNHSLVTESDLFSEQALQFMQEMLPVPAPLWLRFTYADLYKYDKLFKNNAINVTIDGLEYCSGDKPHELLREWFGSKYMSTDENDRATSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ42</accession>
    <name>A0A6P8IQ42_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568560.1">
        <property type="nucleotide sequence ID" value="XM_031712700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQ42"/>
    <dbReference type="GeneID" id="116303205"/>
    <dbReference type="KEGG" id="aten:116303205"/>
    <dbReference type="InParanoid" id="A0A6P8IQ42"/>
    <dbReference type="OrthoDB" id="6022142at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027739801" evidence="1">
        <location>
            <begin position="17"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568560.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21496" checksum="2DFD32D00D8D3664" modified="2020-12-02" version="1">MLIYAVFLVLAIVTSAEVSEVVDDEGKHSCAESDWVKISRHAVCFEALGDHYGSFHNYVRGGIVAAIKLEYVSGMVNCVAAAGGKSHWGCNNDYFKTHPLAVVLTDNRNNMLFPKKEFITYPYGVWYWLPFVHPLDKELIFTDYATPIYFPLYKEMRIWYGEDLKDAWTGAEGDNTGRVCVNVYARFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR94</accession>
    <name>A0A6P8IR94_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Melanopsin-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17 18 19 20 21" type="primary">LOC116303403</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568785.1">
        <property type="nucleotide sequence ID" value="XM_031712925.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568786.1">
        <property type="nucleotide sequence ID" value="XM_031712926.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568787.1">
        <property type="nucleotide sequence ID" value="XM_031712927.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568788.1">
        <property type="nucleotide sequence ID" value="XM_031712928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568789.1">
        <property type="nucleotide sequence ID" value="XM_031712929.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568790.1">
        <property type="nucleotide sequence ID" value="XM_031712930.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568791.1">
        <property type="nucleotide sequence ID" value="XM_031712931.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568792.1">
        <property type="nucleotide sequence ID" value="XM_031712932.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568794.1">
        <property type="nucleotide sequence ID" value="XM_031712934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IR94"/>
    <dbReference type="GeneID" id="116303403"/>
    <dbReference type="KEGG" id="aten:116303403"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="61"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="623"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031568787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031568788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031568789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031568790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031568791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031568792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031568794.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="78662" checksum="29BA66C20D16401E" modified="2020-12-02" version="1">MATTEGLEAATEEFHMEHQKNVTNGSLFLDEGGHYMVLEPQPFRWVLRLIFISVFLVGSVGNLVVCSAILRRKRMQTSNNIFTFNLAVSDLMIVLIYLPSQMAAFENNHNWPFGYFGCQFAYIIIPVCLSASIATLLAITSDRYRAIAYPMKPKLGAKSIRLILLSIWVISLLVALPLVFVAGTVRPEPGQVYCDEEWPKPIYGEIYWISIFVIQYILPLCIIWVLAVLIALKLRRNSLQMIERTSHVLAAAFRQRMKQSSKITNMLIALIILYAICMLPQHLVYLFSIYGDLSKFKYRVYVIRFANVFPMANSALNPIAYGTLNKEFKAVFKNFFKCECHKDVPMEDSIHGQSHFDRGRRLRLAVYRHVDDDGNTVVNNYGHNWRRKSSAASLFAGLFQRSKRGSGRERKHSRESMSRNRKQSNQEHHKTNGNVNNNQSSKVATDSIIDLMDHQEKSPSPKIRFQEPKKYEMERLIPTRMKKGERILENSSRVKKVDGKNFCLVEKDKRPNLCKMKRYDENDSELKQCLLCSQSSTESNATRESEPKHEHLHQINSCTSQEDSINVSGSLEWDPMTTAPPLVQEDKMASHANQNDTNCTLSPDSQSFRNRQNVDLETCSPHEPTELSAFNKTNSGINSTNETCRRTMDDTSENEKPDVTSNPSDPANNSINSDNEWLTLIESVQETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRL3</accession>
    <name>A0A6P8IRL3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ectonucleoside triphosphate diphosphohydrolase 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569517.1">
        <property type="nucleotide sequence ID" value="XM_031713657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304012"/>
    <dbReference type="KEGG" id="aten:116304012"/>
    <dbReference type="InParanoid" id="A0A6P8IRL3"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569517.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21096" checksum="469E9463C50D6930" modified="2020-12-02" version="1">YPCYSGLSRRRSRVPLTAADCKKIISHCHNDGYEEKVKINDKDYLLIGKYNGVLCKKAIRNKIFCNDPDIEECPFIVQPKLKGNFYGFGAIYFALRDVEMLKTDDDIVTVPQIKNSTXTFCAEPAEDLDTSKYEIYGLCFQLNYIYELVKDGYGAGNNFTLHVAKGLHGFELNWVLGAMLEATKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRP0</accession>
    <name>A0A6P8IRP0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Beta-secretase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116303503</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568918.1">
        <property type="nucleotide sequence ID" value="XM_031713058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRP0"/>
    <dbReference type="FunCoup" id="A0A6P8IRP0">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116303503"/>
    <dbReference type="InParanoid" id="A0A6P8IRP0"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050435">
        <property type="term" value="P:amyloid-beta metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000003">
        <property type="entry name" value="Beta-secretase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000007">
        <property type="entry name" value="Beta-secretase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009119">
        <property type="entry name" value="BACE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009120">
        <property type="entry name" value="BACE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01816">
        <property type="entry name" value="BACE1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01815">
        <property type="entry name" value="BACEFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028160262" evidence="15">
        <location>
            <begin position="26"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="16">
        <location>
            <begin position="65"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="18">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031568918.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54792" checksum="DC85D4E72E71C716" modified="2020-12-02" version="1">MRVRIDFCWTTIWLFLMCLLDLSYEQNVPKRKAFHRIPLLRTKRDLRDSNGVPMENLKGRPGQGYYIATNLGKPPQRINVLVDTGSSNFAVAASPHPYVPYYFHIEKSTTYKDLNTVVSVPYTQGNWEGELGSDLLNFIEGPNATVRVDVASILSSENFFINGSMWEGILGLGYARLAKPDSSVVPVFDQFVREKAVQKDSFSMQLCGSSEIEPSAEPTVAGTMVFGDIDDELYKGDLLYTPIVKKWYYEVVITDIAVDGESLALDCKKYNYDKTIVDSGTTNLRVSEQVFNSILDRLRKFDRLGVPDDFWYGRQMMCWNYDKTPWEEFPDMSLSLLSSIGASKEFRLKIPPQLYLRETIEHGPLLGQHCYKFAITKAEKGTVIGAVIMEGFYVVFDRENVQVGFAATTCGAEGRLNPRSEVSGPFSRDPVDCEYIETESSDTALLTVAYVMAGVCGLCLLPIFILLGQASCRRKKENRLLGGSEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS77</accession>
    <name>A0A6P8IS77_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC116304196</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116304196</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569747.1">
        <property type="nucleotide sequence ID" value="XM_031713887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS77"/>
    <dbReference type="GeneID" id="116304196"/>
    <dbReference type="KEGG" id="aten:116304196"/>
    <dbReference type="InParanoid" id="A0A6P8IS77"/>
    <dbReference type="OrthoDB" id="7493297at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027908192" evidence="13">
        <location>
            <begin position="16"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="14">
        <location>
            <begin position="171"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031569747.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="49241" checksum="471E9F76DEE14B40" modified="2020-12-02" version="1">MFWHMLLSVIALVMGEKVLSISSPSQLTREVGQDVVFMINSTAMSEATWGVRDGDTNYLNPRLYRVLSSFGEFPDTKINSTSYAGRVSFVGNLSKGHAWFKISNLNISDTNQYMALIMLQGEKSYRYIATKLDVIQPVPTTATITVPTASSSPTGIITQGQTAFPSTEPPILKNLTTSLKVKREFSKSMEDSNSLSFRNFAKEFQTAIEQAYKNDSNFHYFGSVRVISLREGSINVTFIVFFTSGIKRDSACAPLENAIKDGNLGNFEIVPGSLGCSDPKTSTPRPPASTTGVHPGIIAGVVIVGVLAIAGLVIAILFVCRKKSSKKAYRSSTGPAPGYEMDARHGEPEEQYASVQKPGASVPKQSGDQSLPQYAVVDKSKKNKNKPRESDELVYAVLDHDHNASMSSRPPSDRRSTGATGDTVYADIQSEKKKQRYPPPQYGNIQDNSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUB0</accession>
    <name>A0A6P8IUB0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570629.1">
        <property type="nucleotide sequence ID" value="XM_031714769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUB0"/>
    <dbReference type="GeneID" id="116304962"/>
    <dbReference type="KEGG" id="aten:116304962"/>
    <dbReference type="InParanoid" id="A0A6P8IUB0"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031570629.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20565" checksum="C63E68BAA7DE8F4A" modified="2020-12-02" version="1">MFEWGDIKLENNIKRRGVDDTRRLPYYPFRDDGAEIEKAIRLMITDYVNAMTGQHASVNYPMIDYVTYVPNLPLKLYDSERIPNTTFGPERLPNRAQSASQASFGATLASYREDSLFDYGKNLKDCKGRKVVSRYYNYLKDVVDPLLEMRNHKRLVKGHLTYPYMQPRWVPNGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUQ8</accession>
    <name>A0A6P8IUQ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Creatine kinase B-type-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304313</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569888.1">
        <property type="nucleotide sequence ID" value="XM_031714028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUQ8"/>
    <dbReference type="FunCoup" id="A0A6P8IUQ8">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="GeneID" id="116304313"/>
    <dbReference type="KEGG" id="aten:116304313"/>
    <dbReference type="InParanoid" id="A0A6P8IUQ8"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00716">
        <property type="entry name" value="creatine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000001">
        <property type="entry name" value="Creatine kinase M-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000002">
        <property type="entry name" value="Creatine kinase S-type, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF57">
        <property type="entry name" value="PHOSPHAGEN KINASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="154"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="349"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569888.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46044" checksum="69D7C358E3C9DFBE" modified="2020-12-02" version="1">MLKVLSNKRVLIVSAIGLGVSAYAAAKLFSAGSRFRNYGSHRQFHPMDDYPDVRKHNNCMANHLSPRLYAKLKNKTTPSGFTLDQAIQTGVDNPGHPFISTVGLVAGDEETYEVFADLFDPVIEERHNGYKKTDKHVTDLDASKIRGGNFDERYVLSSRCRTGRSIRGFSLPPHCTRAERREVEKIVVEALSELKGDLSGTYYPLANMSNEEQEQLIKDHFLFDKPVSPLLTCAGMARDWPDARGIWHNKNKNFLVWINEEDHTRLISMQKGGNMRAVFERFCNGINEVEKLMEKKNRQYMWNNHLGYILTCPSNLGTGLRAGVHVKLPLLGKHKDFPNILETLRLQKRGTGGVDTAAEGGIFDISNSDRLGYSEVQLVQKVIDGVNLLVEMEMRLERGRAIDDLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV86</accession>
    <name>A0A6P8IV86_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116305264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570999.1">
        <property type="nucleotide sequence ID" value="XM_031715139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IV86"/>
    <dbReference type="FunCoup" id="A0A6P8IV86">
        <property type="interactions" value="2868"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116305264"/>
    <dbReference type="InParanoid" id="A0A6P8IV86"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000172">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028170426" evidence="5">
        <location>
            <begin position="21"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="625"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="8">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570999.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="85807" checksum="D87BF5BC1DFBDD47" modified="2020-12-02" version="1">MVSNYIIYALFFKVWGFVIANNESRLSTGCGDSELRVWKISYPANTQDAPASELGAKRSAIDADLENESDVLQSDKQESQPVTCELLGSVIRQSRARVTSLHSSNSGQILGCLGNDSQLELFRITTEEEINKSLQKRMKRARKKQRKEATDPEKAKFEDISITRTVEDEFVRVFTLRVSAKTKAFDLHQNFTAEDVKVLLLLQNNTIEVHNIPVSGQIPQSSLVEHVRQPGHRSDVRTISLSSDGMCVLSGSQETLKVWNRDSQQCIHTMSTGYTLCSFFVPGDKHAIIGTKEGKIEIYDIAAGSLLESVEAHEGPVWSLSLAPDKRGFVSGSGDSTVKFWEFELITDENYSKTSKRLGIAHVQTLKLKEEVVCVKYSPNQKLLAVSLLDCTVKVFFADSLKFFLSLYGHKLPVMALDISSDSTLIITGSADKNIKIWGLDFGDCHKSIFAHDDGIMGLQFIANTHYFMSVSKDKTLKYWDADKFEQIMVLQGHQGEVWCLAVSPNGEYVVTGSHDKSLRLWQRTDEPLIIDEEREQERETAFEETLAQGPEQVIPGENDSEARKAGKKTMESMKSAEQLMEAIELHREESAKMFEYRTALKVNKKAPLPPTNPILMAFGNISSSRYVLQVTQKIRSSELEEALVVLPFDYVIDILKLLDEWIKANWEIELSCRCLFFLMRIHHNQIAATSKLLPVIDSIRQNTKRQVHGLRDIIGFNQAGMQFLRQEMEAKEISFFTDATEKLRNIRKKRKTVKQVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVC6</accession>
    <name>A0A6P8IVC6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sorcin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570922.1">
        <property type="nucleotide sequence ID" value="XM_031715062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVC6"/>
    <dbReference type="FunCoup" id="A0A6P8IVC6">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="GeneID" id="116305206"/>
    <dbReference type="KEGG" id="aten:116305206"/>
    <dbReference type="InParanoid" id="A0A6P8IVC6"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16181">
        <property type="entry name" value="EFh_PEF_Group_II_sorcin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF3">
        <property type="entry name" value="CALPAIN SMALL SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031570922.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21746" checksum="7EFC2DA2E2940F80" modified="2020-12-02" version="1">MAYPGYGAPGGYPGGYPGYQQPPMDPLYGYFQQVAGQDQEIDAQELQRCLTASGISGTYQPFNLETCRLMINMLDRDYSGKMGFTEFKEIWAALNQWKTCFMQYDRDRSGTVEPHELHQALSSFGYNLSPAALNVMVKRYAINNRITFDDFVSCCVRLRALTDNFRRRDVSRTGNANFTYDDFIQVTMYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVC9</accession>
    <name>A0A6P8IVC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304495</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570098.1">
        <property type="nucleotide sequence ID" value="XM_031714238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304495"/>
    <dbReference type="KEGG" id="aten:116304495"/>
    <dbReference type="InParanoid" id="A0A6P8IVC9"/>
    <dbReference type="OrthoDB" id="5989132at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028101">
        <property type="entry name" value="DUF4616"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14375">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 4931414P19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14375:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 4931414P19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15394">
        <property type="entry name" value="DUF4616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570098.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50290" checksum="9726EF124022DF8E" modified="2020-12-02" version="1">MVLSTSSFFSGSGNRTRTTTSRSDRSASTNDQDRRETVVVSSLELRQIFESIKILSNTVKEQSGKLEQLNNNVSFVKAELIKLSTTVDEMRSELPLIKEAANEQTGSQHYGPVPKAVKDAVHLLHNKQEDNNKFKGQERVDSSHNSRLRSFLVTELEKDADLSEFSKQTIFRGVTRYYETKRQQHLDTLPERLEAAEKKNYEKKLTSRRRRLFVNRLKVCDENQQERWQELDPILMSDEEDGTGENSGAWLVRKPIWRSPELENLIATLQKKVDERDAKTTFKHPKNRRVLGRPCQRPVPSSSPSWAIRERQPAARSNPSSNSSSSSSSPSQHSTSTPRAQASTPRLITPTSPSMPRNASSSSNSGNSEXQSRKRKASKKKRDHHXNRXRLELSXVVLAVQASSQEYDSSDENISTSVCSSNSSSSKKRYRRIMSDDEDQFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWJ7</accession>
    <name>A0A6P8IWJ7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Guanylate cyclase</fullName>
            <ecNumber evidence="2 14">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116304783</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_031570423.1">
        <property type="nucleotide sequence ID" value="XM_031714563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWJ7"/>
    <dbReference type="KEGG" id="aten:116304783"/>
    <dbReference type="InParanoid" id="A0A6P8IWJ7"/>
    <dbReference type="OrthoDB" id="5975751at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="243"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="19">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031570423.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51484" checksum="E10B9B1528812BBC" modified="2020-12-02" version="1">MSMAVDIAAGMKYLHSSPIKLHGCLTSSKCVIDSHWVVKITDWGLHYFKAGQEKGNLPAQKMYTDLLWTAPEHINLAKLEREGMTQKGDVYSFAIIIQEISTRTGPFNDCGFEPREIIQRVIARDDPPFRPEVSTDEVRAELVLLMIECWNEDPEERPHFLRIVERLKKISGRYRNTNIIENMVSMMEKHSNHLEQLVEERTRQLNEEKEKTDRLLFRLLPQPVAEQFKLYNSVQAEEFEEVTIFFSDIVGFTKLCSNSQPLEVVDFLNDLYVAFDEIISHFDVYKVETIGDAYMVVSGCPVLNDKKHAGEIGSMALDLLSHMTVFRIRHRPEEQLQLRIGIHTGPVVAGVVGVTMPRYCLFGHTVNIAMKMESTGVGLRIHVSREAYLRLVELGGFYLEERGQVKIKRRGMVTTYWLVTKEGFNKPLPDPAPDINEPVFETLDVYYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYB5</accession>
    <name>A0A6P8IYB5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ADP-ribosylation factor-related protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116306540</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with SYS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572481.1">
        <property type="nucleotide sequence ID" value="XM_031716621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYB5"/>
    <dbReference type="FunCoup" id="A0A6P8IYB5">
        <property type="interactions" value="1331"/>
    </dbReference>
    <dbReference type="GeneID" id="116306540"/>
    <dbReference type="KEGG" id="aten:116306540"/>
    <dbReference type="InParanoid" id="A0A6P8IYB5"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031572481.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27669" checksum="8625078E1FD8E0F0" modified="2020-12-02" version="1">MAVSSILEIFEGPNGGVLAVATGLFLVLITTLLLVFLRKGGRRGNAVLLVGLTDSGKTLLFSRLTTEKYVMTHTSMKENKGSYTLKGKNQGKTLDVIDIPGHSRIRFQFLDKQEGQARAIIFVIDSVNFPRELKDVAEQMYDILCNKHLSKAAVPILVACNKQDMTTAKSSRVIKLQLEKEINTLRVTRSAALQGTDGSSKDSFIGRKGKDFEFAHVEPVKVEFVECSCKGDTEGKDPDINAVYDWINKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYG2</accession>
    <name>A0A6P8IYG2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ras-related protein Rab-35</fullName>
            <ecNumber evidence="8">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC116306315</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031572209.1">
        <property type="nucleotide sequence ID" value="XM_031716349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYG2"/>
    <dbReference type="FunCoup" id="A0A6P8IYG2">
        <property type="interactions" value="1830"/>
    </dbReference>
    <dbReference type="GeneID" id="116306315"/>
    <dbReference type="KEGG" id="aten:116306315"/>
    <dbReference type="InParanoid" id="A0A6P8IYG2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Putative ras-related protein Rab-35"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0168">Coated pit</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067828"/>
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    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_031572209.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22845" checksum="B9B15CA9C7C66DE3" modified="2020-12-02" version="1">MARDYDHLFKLLIIGDSGVGKSSLLLRFADNMFSGSYITTIGVDFKIRTITIDGEKVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTSADTFVNVKRWLHEIDQNCDDVTRILVGNKNDCPERKVVETQDAQKFGEQMNIQVFETSAKENINVEEIFNAITKMVLKQKKEQQAKQSDQPKAIKVNGGKKRKKFCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYJ5</accession>
    <name>A0A6P8IYJ5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116306638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031572576.1">
        <property type="nucleotide sequence ID" value="XM_031716716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYJ5"/>
    <dbReference type="FunCoup" id="A0A6P8IYJ5">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="GeneID" id="116306638"/>
    <dbReference type="KEGG" id="aten:116306638"/>
    <dbReference type="InParanoid" id="A0A6P8IYJ5"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000002">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08629">
        <property type="entry name" value="PDE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="270"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="514"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="864"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="866"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="590"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031572576.1"/>
        </source>
    </evidence>
    <sequence length="910" mass="101829" checksum="20F0507BC97C6CBA" modified="2020-12-02" version="1">MGCAPSIHVSQSGIVIREEIRESSSPRPIVSSPSEIVGHIRSSSDSGSHISTSSSSRYRGSYKRSYYSARGSSIEAETQTQDLSMTENIKSEKRPGIMLGPMKLYQPIVQIMLVFAKEDAQTESFVQAAERGGYKYSICKTFEAAMDQFLSNQPEVIFIDMRDSSTIDGEKLCKSMRTKRPSDSSTIIAVVKPCPRHSDEPSFLPLLKTGFDRRFIENTNVGGCFNELKMLEYGEVRSQLKLRATACFINAIEHTHDAVEITRLDPDKSDNQVHVEYVNPAFEKMTGYSRRDVIGHTQKLMYLEQSKPELFEAILSQLKKGTTWEGSFMGKRRNGEQFLQNVHIVPIIGRGGKVEHHVTVKRELKEANSLHNQVNMNMSVNMHMETPSSGTGHRDPIDYSSTLPNGNLHRRPSMTSRIEAPITKVINMLNAAQENSPSSVVQALDRVMEILRTAELYSPVFAGHNTMDADDVMAIDLVGGLMSNGRRRSGCEIQRSSHPFHPSKESGRLAHISHAPEIPAEVSSAMVDVADWDFDILKLEKASNHRPLYFLGMKILNKFRVCERLNISEEIMKNWLQLIEANYHRKNAYHNSTHAADVLHATAVFLAKERVKAVLEPLDEAASLIAAIVHDVDHPGYTNSFLCNAGSELAILYNDIAVLESHHAALAFKLTAREEKSNIFSGLDVEDFRTVRQSIIDMVMATEMTRHFEHLSKFVNSINKRRSSSMDEVHSVHSGRDTPDSNTSSTTALTTPENRTLIKRMLIKCADIANPARPRYLCKEWAERIAEEYFSQTDEEKKRGLPVVMPVFDRATCNVPRSQVWFIDYFVSDLYDAWDAFAYVPETIRHLTDNYDYWKKKADELDAKRAASPSSPTTSTTTAGSSASTALNAASTVSSTSDARSSSMTSLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYN7</accession>
    <name>A0A6P8IYN7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 49 member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116306382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572289.1">
        <property type="nucleotide sequence ID" value="XM_031716429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYN7"/>
    <dbReference type="GeneID" id="116306382"/>
    <dbReference type="KEGG" id="aten:116306382"/>
    <dbReference type="InParanoid" id="A0A6P8IYN7"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572289.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="53515" checksum="5EFF53B09ED6C791" modified="2020-12-02" version="1">MASTNDQNSESAALLDPTASISSLRPTEPEQEAVTEDLDLKVYPQRWYILGLFTLFNATTNLLWNTWPPVQETCQLVFGWDKKNVLIIGALQAVGSIISVVPSSWFLDTKGLRVAVLCSLTLQVVGVLCEVFPIHPFWLRTIFITIGEFLISVAAPAVQNVGVVVLSATWFPPNERMTATAIATLASYLGSASSYIMGPYIVPDVDYGNITYTKGRKIDIDLLRNMTSQAHLNYLESKINEYILAECVIIGILFFAAMLYFPAKPPSPPSKSSAMQRFDFCSGAKNLFRNSHFWLLLVVFSVSNGVSWGWSSVQDLIFSHVGISQKAAGWLGFFANIASLLGIIFSWYTDRMKRHAKLILVGLFITTSCAQMVLTLACEQIIPLTNTVFYTSGILQVVLFGGTVPLIMEIAAECAFPVAEGITSGVLILSVYTINFFFFLGFMFPQASPLWMNWLLVGSSIFCIPLIACYRGTNNRLDVDLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZU4</accession>
    <name>A0A6P8IZU4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305478</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571265.1">
        <property type="nucleotide sequence ID" value="XM_031715405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305478"/>
    <dbReference type="KEGG" id="aten:116305478"/>
    <dbReference type="InParanoid" id="A0A6P8IZU4"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571265.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38449" checksum="B88D2F42A2AA7335" modified="2020-12-02" version="1">MRPAMRLIISVFSVWVLLLVLVLGYYLQWERGMRKVWWSAKDEVTAIEGESXTLAWSINLTDSDVNEHWTFVKIFHAEEPNTVELVTFKRRGGTLIENPSYNSRISDMTFSIFQRFPIVTIRFTMANLVRATDMKSYKAMVGFNSVASTYPGVILLTILVKPHSTELKIKPEKNAYCLGDKVIVTCKADGIPPPHISLFLNGKSIKSEITSVAVTLSLNVKGENKLDCVPINTAGIGQTRNVKLVVKGKEWGGKTVVIAFGIIVTLVLVVIYCKPRGKEWGGKTVVIGFGIICMLVVAVLVVIYCSPRETKQKIMEEVMEEKNSPQCEDRDVIVNPAEYQYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J027</accession>
    <name>A0A6P8J027_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cathepsin L1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116305713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571538.1">
        <property type="nucleotide sequence ID" value="XM_031715678.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J027">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="GeneID" id="116305713"/>
    <dbReference type="KEGG" id="aten:116305713"/>
    <dbReference type="InParanoid" id="A0A6P8J027"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028469569" evidence="7">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="114"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031571538.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36976" checksum="D05AA0F6172DE2A5" modified="2020-12-02" version="1">MKALVIVMFIMCACYGMSELIKDSEWQAWKVFHNKNYETRDEEGLRYAIWKENLEIIKRHNQGKHSFTMAMNHLGDLTSKEVKSMLNGYLGTKKFANKTKFDAVTFLPPSNVNLPKDVDWRKKGYVTPVKNQKACGSCWAFSTTGSLEGQHFKKTGKLVSLSEQNLVDCSQKFGNNGCEGGLMDNAFKYIKANGGIDTEESYPYLAQDEQCXFKKQDVGATDSGYVDVKTQSEKDLQMASATVGPISVAIDASHTSFQFYKNGVYDEPDCSSLQLDHGVLAVGYGVSDDGIDYWLVKNSWGTTWGMDGYIMMSRNKNNQCGIATNASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J033</accession>
    <name>A0A6P8J033_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 42 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116305718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031571543.1">
        <property type="nucleotide sequence ID" value="XM_031715683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J033"/>
    <dbReference type="GeneID" id="116305718"/>
    <dbReference type="KEGG" id="aten:116305718"/>
    <dbReference type="InParanoid" id="A0A6P8J033"/>
    <dbReference type="OrthoDB" id="2134857at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="4">
        <location>
            <begin position="59"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571543.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44733" checksum="72CC016298507D7F" modified="2020-12-02" version="1">METIGKYKLELEDQKENVFVTQLREEDEEDIKVRKFPIVEETSGRLLDTGLNTFQSTLLLKKQVEVEKVHEDLEIKRRQFADRMAACQIKEEELKKKQLQIRERVGKFEKFIKENEAKRRRAIQKYQTELKLKEQKASEQDILSNELEILKAKKARLERKMAKYSVYEKFLLKVLDVVPEDYLETSDSMIMGIMMRFKTLSATNQTLVQMLTDRADEIESSQQKLSDMNQSHTQNLVLMNSELACLQEKLEDTMQKNVELEQHLVNRKAIIRQQSEILGRIKLAIDNLAEKCQKIVLVPVEDQDFDTKLRIIQDHINEYNDIIWLARPTEGSPSVDNTPVTGSPSILKKESRLPRLRPQESSLKSAVPRRSGPMELRFAADVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J192</accession>
    <name>A0A6P8J192_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YdjC deacetylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573254.1">
        <property type="nucleotide sequence ID" value="XM_031717394.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J192">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="GeneID" id="116307234"/>
    <dbReference type="KEGG" id="aten:116307234"/>
    <dbReference type="InParanoid" id="A0A6P8J192"/>
    <dbReference type="OrthoDB" id="8908051at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609:SF1">
        <property type="entry name" value="CARBOHYDRATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="YDJC DEACETYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573254.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22930" checksum="DF91F875DF29BE6D" modified="2020-12-02" version="1">MKLDEMDLGKKGTCLIINADDFGYCSQRNRGIVEAFCNGVVSSVSLLVNGSSSLEAIGFACEHNIPMGLHLNLTEGHPMGKDHETLIDSKGYFKGKMGFRDALRSDQENHLLSKXWIEFMVHPGYRSIKGTGGCGEGPDEFALSKDREHELKILTSQELKNFLKREGIILKSFNNIQTXIFFLNQKMNFLFARQSIKNKTNKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1C0</accession>
    <name>A0A6P8J1C0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116307554 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116307554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573701.1">
        <property type="nucleotide sequence ID" value="XM_031717841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1C0"/>
    <dbReference type="GeneID" id="116307554"/>
    <dbReference type="KEGG" id="aten:116307554"/>
    <dbReference type="InParanoid" id="A0A6P8J1C0"/>
    <dbReference type="OrthoDB" id="546383at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026507">
        <property type="entry name" value="PIRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899">
        <property type="entry name" value="PIERCE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20899:SF4">
        <property type="entry name" value="PIERCER OF MICROTUBULE WALL 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14892">
        <property type="entry name" value="PIRC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031573701.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14051" checksum="754CF1217EA6DA5C" modified="2020-12-02" version="1">MSNGAANTAAETQVAMTQNTSSDLEKTKPGKEAPVGINNLGNPVFSCPATTNATMKIEAPSVEEDCFQGYGSKPTNPMYLTSSMDYGNRSPTVHTMPTSFHAKCQKFSAHLGQCGMYRNYSLNTSLDKSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1E7</accession>
    <name>A0A6P8J1E7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573309.1">
        <property type="nucleotide sequence ID" value="XM_031717449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307282"/>
    <dbReference type="KEGG" id="aten:116307282"/>
    <dbReference type="InParanoid" id="A0A6P8J1E7"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573309.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16559" checksum="FEB79AB2A948144D" modified="2020-12-02" version="1">MINKSFSDNIVKSWNNKSLIIRCFVIGTARPHIIWYSPIGNDITNSSRLTKEGSQLSVITLQDTDYGIYTCLAKDIFGFXQHEINVTNSCICPTIKKRRKARALIENKHPSHKKSNPGLKHKKLYVVCLGIIGVSWVVSLFLILKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J246</accession>
    <name>A0A6P8J246_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307831</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574011.1">
        <property type="nucleotide sequence ID" value="XM_031718151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J246"/>
    <dbReference type="GeneID" id="116307831"/>
    <dbReference type="KEGG" id="aten:116307831"/>
    <dbReference type="InParanoid" id="A0A6P8J246"/>
    <dbReference type="OrthoDB" id="10590348at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028400066" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574011.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24562" checksum="D3E3EBF65398DE82" modified="2020-12-02" version="1">MVKLSICSFWILLIATSSFLFLETRAKEGIAHEHKDHPVQRNAGKKEILPAFEDPEVTVTVTETQYVTITVPPASKCNLTTTQVHTQYLTTFSEASTVTETTTIQTIALETATTIKVTPTDTETTTSVLSTQTTTFLKETTNVVTTAKTEVLLTETSTVELTVTTPIAVTTTIVATQTPTPFVLVKSAGKRDSVKHRSQRVRRSWYTKLIPNVVKKWIGMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2H8</accession>
    <name>A0A6P8J2H8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307658</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573797.1">
        <property type="nucleotide sequence ID" value="XM_031717937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2H8"/>
    <dbReference type="GeneID" id="116307658"/>
    <dbReference type="KEGG" id="aten:116307658"/>
    <dbReference type="InParanoid" id="A0A6P8J2H8"/>
    <dbReference type="OrthoDB" id="5979519at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027947026" evidence="1">
        <location>
            <begin position="26"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573797.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="69583" checksum="57DDC06BBAE98C76" modified="2020-12-02" version="1">MRGNSRLVVYLCVLLFLNEFGPAHFHRVLSHDGYSFNKHGAKGTYNDIVRERRTASSLLRLGKHLFEALEFTSKYFKDVTSLVSMATTIYVVASDNCCSEADREVCDLQEEAKEISEYIDSESKNINKIQLETQNLQALVESLNNLFNTTVENMRNVGYISSKVLEGIDPNIEDTLNVTTLELQKLILKEQNAGKSVDYVVMGKKYFTRIEQVINIAGPVFVTVIPKMVKITKFGSERLGRIKSWEMTEKFKNINLPGTNTAAYKGMKSWFAKTSNYIKAKSESLRTLITTKYSKAVDVVKNLKRGFLTLSGFLTGAYNIYVSIQNIKKCQKIKEEVKGAVEKLRQAKTKFTEIYNNVTKAKENMQKAAEDMYESVASDVFLSDLKEMRDNMLSIQGDSKGMQDMISQTTKYIDSIKSSKDLNDVVPLFNGLYHALGILPFVYNCLYDKTWFIGSIARGCEEGDKPLTELVTLARHQYSNNIKDCEERTGIPYITDETIRDMIDKAAKDKGFNQNCVLNSKTLKDFVCSMKCQPLDFDDIASRLSPRGISKDTVKILYDDCPPCENDKEKDVKMVCMIKKLQPKIKDKEIQELVPKLTLDEIAKIDCSKVNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5A1</accession>
    <name>A0A6P8J5A1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane emp24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574854.1">
        <property type="nucleotide sequence ID" value="XM_031718994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5A1"/>
    <dbReference type="FunCoup" id="A0A6P8J5A1">
        <property type="interactions" value="2915"/>
    </dbReference>
    <dbReference type="GeneID" id="116308544"/>
    <dbReference type="KEGG" id="aten:116308544"/>
    <dbReference type="InParanoid" id="A0A6P8J5A1"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028220398" evidence="10">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574854.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23322" checksum="47F2DF825719B231" modified="2020-12-02" version="1">MTTINILYCCVSFLFLLRSSYCYFITIDAHGEECFHDRVTSGTKMGLIFEVAEGGFLDIDVKIIGPDQKVIYSGERETNGKYTFAAHMDGVYNYCFSNKMSTMTPKIVKFSMDIGEAPKDTSKDDNASHDKLSEMVGQLGEAMTGVKHEQEYMEVRERIHRSINDNTNSRVVWWSFFESLVLVAMTLGQVYYLKRFFEVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5I8</accession>
    <name>A0A6P8J5I8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Opsin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574949.1">
        <property type="nucleotide sequence ID" value="XM_031719089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5I8"/>
    <dbReference type="GeneID" id="116308618"/>
    <dbReference type="KEGG" id="aten:116308618"/>
    <dbReference type="InParanoid" id="A0A6P8J5I8"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF34">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574949.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40281" checksum="5D9850DF61AB03CF" modified="2020-12-02" version="1">MNFTSVPTNITTSLSAKQCHANPVYFSLMAVIHILTFVVNFLTAVAIWRLPGLEGNKYHLVVRTLIVSDCLISLSSLPMSMISFINCGWVGGAVACILSAFFSTAFLSWSAMIVIVMCVMRFLAVKKPLLYRNSVTYLRIKKGLAVAFIWGVLHLALPLAGLGKFRLYERGYFCALDITPVRPKDKTLVYITVTEGCLVMTALVYFSIVVMVLVKKKRRVSTSLSVQQRRGVGVEAINKREGGFATMTFVIVLVYCICYVPFLIYRTVVVVRGPSLINEYTYYFTELIAHLNPLLNPVVYVACSRQYRSSIKRLFDNCCLYRLSLLMQKYLVESYGGSSSIELRKMSSLSARSETTIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6B2</accession>
    <name>A0A6P8J6B2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TNF receptor-associated factor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116308925</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575304.1">
        <property type="nucleotide sequence ID" value="XM_031719444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308925"/>
    <dbReference type="KEGG" id="aten:116308925"/>
    <dbReference type="InParanoid" id="A0A6P8J6B2"/>
    <dbReference type="OrthoDB" id="5980013at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000001">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012227">
        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF153">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015614">
        <property type="entry name" value="TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57953">
        <property type="entry name" value="Trimerization domain of TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="14">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="14">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="13">
        <location>
            <begin position="356"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="11">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="11">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031575304.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58282" checksum="8860DBE99988F109" modified="2020-12-02" version="1">MCSECLQKRLRGPSPHCPLDNEPLSEREVFNDVCCKREVLGLICFCMNHKHGCEWKKELMYLEEHLSHCEYREVPCPNQGCKEMIPMKKLDQHVKESCLFKPSSCQHCGERVPEVQMEAHLLKCEKVPITCQYCGMSDILRELQNDHIENHCEAAEKPCKFKDVGCLFKGKLEDLNEHYDCQKDEHLKLTVQSMDSSKKLQEQLSQKVDKAKEKTEKLEKELSEHRESLASNAQNLRSYQARLSKAEKGVTENKSAIAQIRERTEDAASSKGGKTCEVSLLLEEFRSALADQEEKLHSFERELARGVGGGGLRSFSSSSLTLDRRLDRNEHQLALHDIQLAEHDLKIQMLEAXSYDGTYIWKIDEFSRRNHEGIIGKTPSIYSPPFYVGRYGYKVCARVYPNGDGMGKGSHLSLFFVIMKGEYDALLPWPFRQKVTFKLLDQDRQQDITDTFRPDPNSSSFKRPTSNMNIASGCPLFVSQQVLLSRSYVKDDTLFVKINVETAGLPPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JB31</accession>
    <name>A0A6P8JB31_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116308601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031574923.1">
        <property type="nucleotide sequence ID" value="XM_031719063.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308601"/>
    <dbReference type="KEGG" id="aten:116308601"/>
    <dbReference type="InParanoid" id="A0A6P8JB31"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF893">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028506740" description="Metalloendopeptidase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="5">
        <location>
            <begin position="75"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="652"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031574923.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="90093" checksum="22E78FAAFC726A98" modified="2020-12-02" version="1">MFSRHETWSRAAVVILLLSLTDAALDNLQDKRNVTSMDAVVEANTKESLTGRTQDALDDMIFPKITSSAGSQDYSAAADARHKIWPNGKIFYKMSRNITQKPNYVRVIKAAMAEWERGTCIRFINKTNSNDVKEYVYIYYGAGCRGSVGKWDGKTSLLSLGKFCDKFRIVLHELGHTIGFFHEQNRQDRDYYVEIIWRNINPRWTRAFYLRRNRIKKPSTPYDYYSIMHYGTHTYSINGKPTLKSRDPSVKYLGNTGLSLMDIKQTNILYNCFDFPNFPEDFFFTKGKQPKNPNCVAMDEPEDPLWNTTNICYKEDKKINIVWSKSGRVSSMICTNTAIPHRDSYACFWQDNYICVPRDSVLRFGWSVSGPINGMKCVGIRVHAGSPYLYYLCAVRTNKVTPNDNKVLQSNYTSWSPWQPCSKECGGGNQSRFRQCKNERLCTGSLVEMRVCNKNKCSSWPHWPRDFKFYIGLSKIQSITTCINIYERNQYIQWLNHKFCWLIMRRRKLKILWSDXNEVPGMRCTQISEPQEKKNSGWDNNYLCVQQDAPYRFHWSVNGLIDGLYCLKWMGKEGMDGWDNNYLCADKYPEINYTSWSLWQPCSKTCGEGMRSRLRHCKKGKICNKRLNETRVCHRKKCPGCPNNWETWKTNGNHFCYLFVYNISTWPEAQMACEEHNANLLSIGSQEEFLFIKKNIQKGNNIWIGANDRKTEGRWRWTDGRNFTFSKWSSGEPNNGGSKNNEDCAMMRKDGRWNDYPCAESDTFSYICKQVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCC5</accession>
    <name>A0A6P8JCC5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Testis-expressed protein 47-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575253.1">
        <property type="nucleotide sequence ID" value="XM_031719393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCC5"/>
    <dbReference type="FunCoup" id="A0A6P8JCC5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308880"/>
    <dbReference type="KEGG" id="aten:116308880"/>
    <dbReference type="InParanoid" id="A0A6P8JCC5"/>
    <dbReference type="OrthoDB" id="548795at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009882">
        <property type="term" value="F:blue light photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007024">
        <property type="entry name" value="BLUF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055308">
        <property type="entry name" value="TEX47-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24787">
        <property type="entry name" value="TEX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01034">
        <property type="entry name" value="BLUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50925">
        <property type="entry name" value="BLUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLUF" evidence="1">
        <location>
            <begin position="36"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575253.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28347" checksum="6C4E0C68EDE3E68D" modified="2020-12-02" version="1">MAATPGGEESVYETGRLSLLDLIFEKNRAQNKKQLVHRLVYISKIRQDVADRREVGAHYEKLFKNSQAQIHGEAVSGLLLIYPVHIVHVLESSANVLQEVINDLAEEEEQSIGGMMHNSRILVYSGDLQNRLFTQWSFRCINQSAARMQEYTTNESIDVAVMEALNLLLKLGEYLGKLPKLSFSKTMDQLPEKVPELLVRQDLLEYLINSKELSSPSEYLKRYTKPLNVVLESELVWPMQTKLFPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0R3</accession>
    <name>A0A6P8H0R3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor IIIA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550024.1">
        <property type="nucleotide sequence ID" value="XM_031694164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287484"/>
    <dbReference type="KEGG" id="aten:116287484"/>
    <dbReference type="InParanoid" id="A0A6P8H0R3"/>
    <dbReference type="OrthoDB" id="6021436at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF20">
        <property type="entry name" value="TRANSCRIPTION FACTOR 3A PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550024.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="51605" checksum="28D929CEADAD4125" modified="2020-12-02" version="1">MIHHNNMEDKKRIECDVCGKTFNKNWRLIEHKRSHTGERPFQCNHEGCNKTFVRPYHLKRHQLTSHSEEKPFKCSYPGCSLAFSIKHNLKRHEKRAHDKPFKCKFEGCCKTFSKGTQLRKHECAHENKLPYSCERDGCDERFATAQKLKIHIIRKHEQGQVYFCSHENCGESFSRFHDLNKHVTSHGYKCLKCGKVFKERYELKRHAVIHDDERKVFKCPVEECDKFYTKAYNLKIHVQCYHEGMKSFSCDVENCDKQFAYRRSLEKHMELAHAKKKPAPKRKKSHKTSNKKPRVEDKEETNATSVDQATGGRNDDRSSEQPKEAEEKEVMTETGEKRFKSCAEKKDSTLNDVDNGDDGNEGSCANDDDEDDANEDDADDEERVDKAYXNKSGSKNESCDKNQNEKKIEDEENDAGTSQEKGDLFMTKEHCVPGAIKEQPIPVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H111</accession>
    <name>A0A6P8H111_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Keratin-associated protein 10-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549066.1">
        <property type="nucleotide sequence ID" value="XM_031693206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286649"/>
    <dbReference type="KEGG" id="aten:116286649"/>
    <dbReference type="InParanoid" id="A0A6P8H111"/>
    <dbReference type="OrthoDB" id="5978403at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027762644" evidence="1">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549066.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="44796" checksum="C2FCDAC05FD38752" modified="2020-12-02" version="1">MMLVVLGAVLSSIFILDGVSAVDQCEQVIGNTTAQICINGNCSFTCGNAGNPHDVCDQLCLQMSKVPCPLLRCSNAKDCNQRCWSGGCNTLDCVSSESCEQSCSVNCSMXECNSKKCNQQCEKGGCKLSAXGVDADQTCSLSPCSDIHCXSTGTCNQNCQGGGCKLRCTNSQTXECLQGCNKGGCSFECSSKSCESACSHGNCPKMTCNGQNCTQTCQKGCSSITCSSERCKQTCNGEDCNLSCANRQSESCVQNCKGSCRAECVSRDCDTTCSGSGCDLSCANPETESCDQVCSHAKGSCNIDCKSKACKSTCVHGSCSKMSCNGTSCSQLCTGGNCTEMSCSANTCTLTCEGGNCKKMSCDASVQTCTMKCAGGSCAMRCDAKXCNVEECEGCIRTGSGISTPKPKSGSSPTFASILFVFTGLIGSVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H160</accession>
    <name>A0A6P8H160_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC116287595</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116287595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550143.1">
        <property type="nucleotide sequence ID" value="XM_031694283.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550144.1">
        <property type="nucleotide sequence ID" value="XM_031694284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H160"/>
    <dbReference type="GeneID" id="116287595"/>
    <dbReference type="KEGG" id="aten:116287595"/>
    <dbReference type="OrthoDB" id="10481935at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550144.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="15929" checksum="EA8F47B1B161A0F0" modified="2020-12-02" version="1">MATEPPTPKPSSNGPDVMTTTNTSGNSTAGILPLPTEKPTIKIKDTSHNQKQTVKIIVAVVVPVVILLVIIAVVKYCKKKKAQNVIANEEFPLQRRSSEKFVQQNASGIDNDPEDPVIRGQDNLDDEAVEEYVDSEFGEIRMELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3Y2</accession>
    <name>A0A6P8H3Y2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Keratin-associated protein 10-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC116287723</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550271.1">
        <property type="nucleotide sequence ID" value="XM_031694411.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550272.1">
        <property type="nucleotide sequence ID" value="XM_031694412.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550273.1">
        <property type="nucleotide sequence ID" value="XM_031694413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287723"/>
    <dbReference type="KEGG" id="aten:116287723"/>
    <dbReference type="OrthoDB" id="5952690at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653009" evidence="1">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550273.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="56153" checksum="8943200E385CBADF" modified="2020-12-02" version="1">MKVLFLLVLATFPVLVNPTKLVNSCTSYKSRACRQHFIYGSLDINCRSHSKACDQKCIRAGCSMNCATSKPCRQRCVASGCKTMVCNSHKCTQSCLQSRCQMECNGERCKQSCEGGFCNMTCPGSARKCIQSCQGGGCLMVCPKGVEYCEQYCSRGKCFMMCAGRVCQRTCGSNGECRVSNRPIVTSLTRPSSRSKMNECSSVSYNMCFQKCLPGKCDIXYDNIKPLGWGSTQVCLGGNCVLGCNNKNGKCWQNCPGGRCLPMTCNSRMCIQECGGGACVMRCTALKCNQVCLGGACTMECSSRVKKCYQSCQGGGCLFKCNARRCFKLCPSGNCRSISPPTVLPKIPGECKYMKSGRCKQECSQKRCALSCKGSKPYGSCDQTCAQGRCRLKCHTPNSCKQTCKRGKCIAMTCKSKKCTQDCTGNQCRMACTSDNCQQRCNGRSCSMDCASGTKNCHQICDGGGCVFNCHGKKCTYSCKGGGCVTRVAEASPDASNKISDKTYFLSLFSKKGQGRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6R9</accession>
    <name>A0A6P8H6R9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Centromere protein T-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116288512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-T/CNN1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551181.1">
        <property type="nucleotide sequence ID" value="XM_031695321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288512"/>
    <dbReference type="KEGG" id="aten:116288512"/>
    <dbReference type="InParanoid" id="A0A6P8H6R9"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028255">
        <property type="entry name" value="CENP-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="7">
        <location>
            <begin position="319"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031551181.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46971" checksum="32427644C6A33EFF" modified="2020-12-02" version="1">MERATPSARDVAAKIFGRSGLVTSTRNIKAHVTTPSEDATPRTLIGGILDAXSVSKSSLVASRKSKLTKSPATGPPRKKKKAIRQSLGDNATPRTIIKNFLMEASPETPLVVPLKLPENRFQDNDNDTSSQSLPHDMQASTSSLQQDSTTTENEIPDHEIDSLPNSEDSQTPLAGEMKEGNDAFLRQNSVNKNXEDAKVLSHVPVNTEADIPEIAPEGVNEFSTRTMTNDEQESHSDSIPDEDIIMPSVDTSSEPPEKSRWKDLVTPHLPLKTRKILLEKQTAQEEEEEEESKRVPKAARKPPTINKRIKTKSTSSGDTNLPSGLVKSIFQHFSKSRISKNTLNSIEKGSSVFFKQVSSDLMAYSSHAGRSTIEIGDVELLMKRQGFITDKQSLNSLIEKYLPLEYRQELIPVVQSGNNVVLKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8P1</accession>
    <name>A0A6P8H8P1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116289969</name>
        <name evidence="8" type="synonym">MED4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552789.1">
        <property type="nucleotide sequence ID" value="XM_031696929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8P1"/>
    <dbReference type="FunCoup" id="A0A6P8H8P1">
        <property type="interactions" value="2795"/>
    </dbReference>
    <dbReference type="GeneID" id="116289969"/>
    <dbReference type="KEGG" id="aten:116289969"/>
    <dbReference type="InParanoid" id="A0A6P8H8P1"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="58"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031552789.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29961" checksum="B229FAA1DDE7C5B7" modified="2020-12-02" version="1">MIIKMAAKMNRETSTKDVVNSILDDYEKLTRQLFENLSVFSLYRGKNDASEGDTTEIVNKLTEKDKELQAAIKIAKEQMDCQLQIQVTKENMAKKDQEILRLENQLKETEQILSQAVFQAKKKLKAIEQANRGSVSSEELIKYAHKISSSSAVEAPTTWMPGDQGRPYPLDIEMRSGLLGKLGEGLDTIPASTLTMDGTSMATTTSLADDGIINGQSTVGLSWQSHLQRLPNTIEQDTTSDGNIGAANGRPDHAVTEEAEIMSSSSSSSSSDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9H4</accession>
    <name>A0A6P8H9H4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tudor domain-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116289073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
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        <property type="nucleotide sequence ID" value="XM_031695963.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="SNase_OB-fold_sf"/>
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        <property type="entry name" value="Tudor"/>
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        <property type="entry name" value="Tudor_domain_containing"/>
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        <property type="entry name" value="Znf_CCCH"/>
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        <property type="entry name" value="FI02030P-RELATED"/>
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        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
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    </dbReference>
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        <location>
            <begin position="143"/>
            <end position="172"/>
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        <location>
            <begin position="274"/>
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    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551823.1"/>
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    <sequence length="440" mass="49991" checksum="D9F6C48D2B77C4DD" modified="2020-12-02" version="1">VYYPTASARDGSRTDITYKRPTLALKLYDTTGEEDIDTGQVLVDTGLAELCEEEVQEVEEFFPVDGERDEAKTVHISLVDLENTADQLEREGATISPLGSRCSSPDEEALNLWNPMMEDYVSSTNSYRIDKDDLDIALYGFKPIENQVCRFFQSTRSKCWRGQNCPFLHVKKGEDASMMVQAFCENSDFTVDLPGLGSWVGVRVTAVLNPGHFWVQFPCGSGPIEKRIMEARLGLNMDDGKEKDEDEDEDFETMAEKMNKFYSRNLFRDSSSILPAMGELVVAQYSSNDAWYRARVTDVRDEEFQVYFVDYGNTEWTAERNVKRMLPQFLHIPFQAVECFLANVETIEENGEWSAEANEVFESLTQDKLLIAHVLSIACNNTMYLELYDTQTNEVNINEELVKQGFAVESTIRIVKPRQVKTVTASDEDSSDCEIIEMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9I2</accession>
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        <submittedName>
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    </protein>
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        <name evidence="6" type="primary">LOC116289409</name>
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        <name type="scientific">Actinia tenebrosa</name>
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            <tissue evidence="6">Tentacle</tissue>
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        <property type="nucleotide sequence ID" value="XM_031696321.1"/>
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        <property type="entry name" value="MG_RAP_rcpt_1"/>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="24"/>
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        </location>
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            <dbReference type="Pfam" id="PF06401"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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        <source>
            <dbReference type="RefSeq" id="XP_031552181.1"/>
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    </evidence>
    <sequence length="323" mass="38590" checksum="0B4D5CB5A572D55E" modified="2020-12-02" version="1">MVHFIRTVLAILFLFIFNDVSFARQDDKPFRMHKLNIIWQKVRSKMSTQKLESLKHALTQQDAKELKWKELKAHGGDASGEQEAKLRRNLFQILDKYAFGHLVEGHQKLSEPGVEDNTVREEGMFNNKKLHQLWDVAEKQGKFDNEEMDDLKTEFKHHQGKIEEYNMLLKILQEQHDISDNSINIHERMNENQIDKLKDELKDKYSEMNKHYAELKEKITGEKDKSQFKDYRVVELWERALEKNFSEFELQSIKDELKHFDHKISKHEHFKKQVEKTERMLKAGEKVDHQTHKNAIKKAKEHGRYVKKLHSTLLDRVSHRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9X5</accession>
    <name>A0A6P8H9X5_ACTTE</name>
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        <submittedName>
            <fullName evidence="8">Protein DBF4 homolog B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290339</name>
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    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <tissue evidence="8">Tentacle</tissue>
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        <property type="nucleotide sequence ID" value="XM_031697384.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Znf_DBF"/>
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        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZnF_DBF"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="240"/>
            <end position="290"/>
        </location>
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        <location>
            <begin position="105"/>
            <end position="132"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="230"/>
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    </feature>
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        <location>
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            <dbReference type="PROSITE" id="PS51265"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553244.1"/>
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    </evidence>
    <sequence length="356" mass="41004" checksum="92A2DAE37B9A007F" modified="2020-12-02" version="1">GDRLSKGARQKWTTLTKLDFITLTKSAQSHCFTTQNTQSPQSSSLLRRRKHALPRPLHGESFYLDVPKKSRSDKLEEAIVQLGGTMARFLSKHVTYVVTDRPDIRRTSPRFHPSRGQTMLQNAKPLPSSISSSDVTRXAKTWKIPVKTFDEFKEWLKERKVADQKSRTPKRNTKXRRLRGAFIKVEDRSRKYRPLVKEMKSWPRPNLDAKPGNGPFDDIKRARRSSTPLSPRRKRLFRKATLKKGYCELCDTEYDIGTKQHLEGNKHRSEANVPDKYSDVDKLINSGITLKQFIERVNKRHKIKTARETPTKQPERTTAPQTVIIRRSARLVAASLEGSAYFTLPATVTYTLPHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBD7</accession>
    <name>A0A6P8HBD7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289631</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552438.1">
        <property type="nucleotide sequence ID" value="XM_031696578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289631"/>
    <dbReference type="KEGG" id="aten:116289631"/>
    <dbReference type="InParanoid" id="A0A6P8HBD7"/>
    <dbReference type="OrthoDB" id="408971at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552438.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="72888" checksum="9F4A6793FD226AFD" modified="2020-12-02" version="1">MSVTVGKLKFLDSQQFMVDSLANLVRYNTEFPISSQYGAERKGVYPYEYMSSWDKFEEPLPKDFYSTLTESGIKDEEYQHALDVCEKYSCENMGEYHDIYLRSDVVPLADVFQSFRKMAMEYYGLDPANFYTAPGLSWSALLKKTNMQLDLLTEYDMYRFMEGGIRGGVCGPSRRYAKANNPTVEYDPEKPTTYIFYLDANNLYGWAMSQYLPVRDFEWDKVKPIDFYMQVDKEAEKGYVLEVDLEYPTHLHNAHDEFPLAPEAIEIPFTQLSPLQREMCPSYKPYRKLTMNLMDKKKYVVHYRNLQFYVRHGMRVTHIHRVLKFTQETWMRSYIDFNTQKRTQAKNDFEKNLFKLMNNSVLGKTMENIRKRVSIKIASTREEAEAYVSQPGFVRYVEMLNFYVIHMKKANLFLNKPVYTGFTVLDLSKLLMYEFYYDKLKPKYGDKCRLLYTDTDSLILEVQTEDVYEDCVPDINEYDTSDYPRDHFLYSAKNKKVIGKMKDEMKGKPIVEYVGLKPKMYSVLKLDGVEKKANGVKXYVVKKDITHESYLKVLRTRKEQRHTMNSLRSYGHQIHNVTQEKVSLSAFDGKRWMCDDGIHTIAFGHHTISSSSLTNPRVGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCH4</accession>
    <name>A0A6P8HCH4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="9">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031550377.1">
        <property type="nucleotide sequence ID" value="XM_031694517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCH4"/>
    <dbReference type="FunCoup" id="A0A6P8HCH4">
        <property type="interactions" value="2912"/>
    </dbReference>
    <dbReference type="GeneID" id="116287820"/>
    <dbReference type="KEGG" id="aten:116287820"/>
    <dbReference type="InParanoid" id="A0A6P8HCH4"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000066">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase SSU72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550377.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22427" checksum="A01DDF5CB9CB1625" modified="2020-12-02" version="1">MVHKLRIAVVCSSNQNRSMEAHNFLSKRGFDVKSYGSGTHVKLPGSAPDKPNVYTFDTTYEEMYKDLLRRDSNLYTQNGILHMLDRNKRIKANPERFQDTTDEFDLIITAEERVFDQVIEHLESIGQQSYTPVHVINIDIQDNHEEATIGAFLICEICKDIQELDDVEDEIDEVIQKFEKKCKRNLLHTVAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCM2</accession>
    <name>A0A6P8HCM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550437.1">
        <property type="nucleotide sequence ID" value="XM_031694577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCM2"/>
    <dbReference type="GeneID" id="116287868"/>
    <dbReference type="KEGG" id="aten:116287868"/>
    <dbReference type="InParanoid" id="A0A6P8HCM2"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550437.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11379" checksum="9BE176601D18CEF3" modified="2020-12-02" version="1">MLKETITKDFWICMAAEFLATFFFVFLTTGSAITWDPSRPPTTEHISLSFGLSISTLAMSILHISGGLINPAVSAAQTVTGKISPVRGAFYIIVQVIGGSANNNIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HD98</accession>
    <name>A0A6P8HD98_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">WD repeat-containing protein 86-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9 10 11 12" type="primary">LOC116288078</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6 7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550664.1">
        <property type="nucleotide sequence ID" value="XM_031694804.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550665.1">
        <property type="nucleotide sequence ID" value="XM_031694805.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550666.1">
        <property type="nucleotide sequence ID" value="XM_031694806.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550667.1">
        <property type="nucleotide sequence ID" value="XM_031694807.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550668.1">
        <property type="nucleotide sequence ID" value="XM_031694808.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550669.1">
        <property type="nucleotide sequence ID" value="XM_031694809.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550670.1">
        <property type="nucleotide sequence ID" value="XM_031694810.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550671.1">
        <property type="nucleotide sequence ID" value="XM_031694811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HD98"/>
    <dbReference type="GeneID" id="116288078"/>
    <dbReference type="KEGG" id="aten:116288078"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044715">
        <property type="entry name" value="WDR86-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489:SF11">
        <property type="entry name" value="WD REPEAT DOMAIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031550665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031550669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031550671.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="40967" checksum="BD62FEE1349FD437" modified="2020-12-02" version="1">MGSGSSKSSKKGGKGKKDKTFLIKSLEQHEGGINSMCLSQGGSTIITVSEDKTGRLWDTKTEECVGTLTGHTGYITYVCASDKYAFTGSSDKTIRKWNLETGACCKVFEGHASVVHRLIYAGDILFSSSYDKTIRCWHADTGEKLKVFRGHKRGVHPILLVPSEANRGTYIDMDNSDDILVSGSSDNTAKAWEMNSNDCLITFKGHEGPVLCLAVDGKGKLLFTGSSDCTVRSWDLLTGAPIKVFKGHSASVLSIQIVNKLMYTCSADYTARCWVVEFGDCTRTYKGHKHVVSTMLVQDGLLFTGDGDGLAKAFDAKSGVCKRTFKGHLYSIASLLEHKNKLYTASYDCTLKIWDTSNIRENEDDIYSQENGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEZ3</accession>
    <name>A0A6P8HEZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 558-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116288518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551187.1">
        <property type="nucleotide sequence ID" value="XM_031695327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288518"/>
    <dbReference type="KEGG" id="aten:116288518"/>
    <dbReference type="InParanoid" id="A0A6P8HEZ3"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF2">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551187.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="60858" checksum="446A9B466F3BEB58" modified="2020-12-02" version="1">MADEETGINESNAKTASSDVSMDQTPLIEHVAPSPLVSTAQLITSQTDSCQSVLPMSTXMTSHVSTCTLTPITTVTSMGEESHAALLFLLNTSSPPSQAETTTSYSGLSSFGNAVFVPQPVTINVMAQGQNSLSKAINNSDGGSNVIEKAMDLANLGEMPGGESVHHPVTNAALTLVSLGSAVGQPVQEIVIDERGRSSLSHDSNLGEVSVTVESEGSSPMVHKSQVGGCTMVASTSGISNMDNIDDKTELRAKLREVVTQTGGGEKEVVVLKAIARSNHKSLSSLLVNQSLERKRLAELKETQKEEIEKERAHPCDKCEKKFFTKHDLKRHYLVHSEVRPYECQTCTKAFRTPNELKLHLPVHNTDTPYKCEFCGKEFRTKGCIKSHIKYHIGDKRHKCTLCGRAFVKSADLKRHIAAHNNEKKFKCDECDSMFTRRDNLKAHMLLHSRKSVVNCKMCNKEFINEVYLKRHMHIHKQAKKKPYECQWCPKTYEQLEGLRRHIRQHVGDEKFVCEHCAKKFITAIQLKRHLWLSHEQNSPYRRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF09</accession>
    <name>A0A6P8HF09_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Intersectin-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116291310</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554336.1">
        <property type="nucleotide sequence ID" value="XM_031698476.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HF09">
        <property type="interactions" value="2335"/>
    </dbReference>
    <dbReference type="GeneID" id="116291310"/>
    <dbReference type="KEGG" id="aten:116291310"/>
    <dbReference type="InParanoid" id="A0A6P8HF09"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08375">
        <property type="entry name" value="C2_Intersectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11837">
        <property type="entry name" value="SH3_Intersectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11839">
        <property type="entry name" value="SH3_Intersectin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000029">
        <property type="entry name" value="Intersectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000055">
        <property type="entry name" value="Intersectin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="EH" evidence="16">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="16">
        <location>
            <begin position="253"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="826"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="973"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="1135"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="1235"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="15">
        <location>
            <begin position="1319"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1543"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="1661"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="655"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="888"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="660"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="947"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1200"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031554336.1"/>
        </source>
    </evidence>
    <sequence length="1799" mass="203109" checksum="D2506E3409426196" modified="2020-12-02" version="1">MASIGSSQGPWVISAEERMKHETTFQSLKPMSGFLSGEQAKQFFLKSNLPPIVLGKIWSLSDFDRDGKMTMQEFTVAMHLIQNKLKGIEVPTVLPNTVKMTSLPASNQPGKKASPSYGPQGVTNGFTNLSGSMTLPKSSGISWSGVNQPNISPVPSSGISWNQPNISPAPSSGISWSSMNQPNISSATSYGVPSSSFSMKSGGGFNTNTTNIGFSNGPGIMTSSIQPQSSLSQGNILQGTMNTSSSNTIATAARLKYNQMFKSLDFKNTGVLSGEQARSVLIQSGLSQTLLAKIWSLSDLDKDSQLNIEEFALAMFFVDMAKQGKQLPNQVPQELLPLAYQGRVHSDSVGSEGRDRSGSNISLDGRSRSGSMAEDKRIFTFEDRRKQNFEKGRLELERRRQDLQEKLKRERDERESKERQQEERKQRAKLEAEQRRQAEIEKQRQQQLEMEKEQEALRKKMIQQRLAQQIEAERQRQLEWQKRKEEELLNQKGLEQDIVNNLKTRKKNLKDDLAVVVGKKTAAQQGFDQEQQLCTEAQTTLNDVNQKKEMCRMDINRIQCEIKEYQQRLLALSNEKERVSLELNKRDTSKMAEAHGNAMASLQDSKAAIKRKQTMQNNLEKDLNEKLKELDSWNVQLKEAQNNVQQLTEENTRLQQTVESKQREYTMWKQKKDDEERMKKELDAKRKREEEENRRQKEREQEAMRKEQEQQRKDQEIRRRMQEAKEAEARRKDQQLLTKDKIVVQQQQTLVKTQPAIVWGEPAKKKEENIISKPVSVWGEPAKKQENIVSQTWSMKTTTTTTSETKEVATKKGVAVPRPRPRPAKKNVQYYRGLFSFDPRNPDEMKIDEGDIVTVDLDNMKAPPGWLRGKSEDRFGLFPENYVESITEDEAKRSTGHVETTSPETTSPGEKVPDVSVKSLVAVISQQLGGGSESADVHMNVHPARETTTTTTSMTTNTTTTDGPRAEGGVPAPKGLTAVALYAYRGKKDDMLSFAKGDLISITEQQDMWWSGELNGKVGWFPKSYVKLTSNTAKNTATTGLQPKSDVINSDFSAVNEPVSETRSEQNQPVLFECVALYPYDGEEGDLSFVQGDAISITKSDGDWWEGKLRGKHGLFPANYVKKVENEGPVAAQRSKPEIATVITAYTATSPDQLSLAPGQLIRVNKRDPSGWWDGELQARGKKRQSGIFPSTHVKILSKSTSPTPTPTAAGGTTPSDEANIYEVPPSNKAAVPDAKLEQVLAMFPYTAQNQDELTFYKGSVINVISRDGDWWKGEMNGQVGMFPSNYVQALSDLPESTTQWTGSFDAKVLASMSDVERQRQNAIYELINTEQTYVDHLSLTLEVFYNPLAESNLLTMEELSTIFVNWKELIHCNTKLLKAFLVRKKMRNNGLIVMIGDLMCEQLPHFSPYVRFCSRQLKACQFIQQKIETNPEFKQLEKKCCSEPRAMGLPLSSYLLKPLQRMCKYPLLIRQLLKYTPKDHPDRLNLESALEKAEELCNQVNEGVRSQESSDRLEWLQSHVNLEGLGEQLIFNSATNCLGPRKLIYSGTLYKVKSGKELKAFLFNDFLLFTRPQSSLTGNLSKKIGLDANEAATQYTIYRKPIFLNEVVVKRPADLNSDDYSFQISHIDRVYTLKTDSKLERNKWIEHLEKAAEHYIETERFTRLKAHRARSLRTPGIGTLVVTILEGKDLATSDPSGLSDPYCEVSMGSQEHRTKVCPQTLNPKWNSTMSFVIKDMEQDVLCITVFDRDLFSPNDFLGRTEVSLSSLRKKTNSKGPWVERLLLHEVVTGEVLVKLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF76</accession>
    <name>A0A6P8HF76_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuromedin-K receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553678.1">
        <property type="nucleotide sequence ID" value="XM_031697818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HF76"/>
    <dbReference type="GeneID" id="116290717"/>
    <dbReference type="KEGG" id="aten:116290717"/>
    <dbReference type="InParanoid" id="A0A6P8HF76"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553678.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33188" checksum="E793E42F8423D1E0" modified="2020-12-02" version="1">MDKSLLFSIFACVLVSIAVAGNLLIVIAVWKKRFLRSTTNYLLVNVAFSDLVSLCFLPLMLTQRYVKFNEGVVADMLCKFLISFNIPLTASFAAICTLVVLSVERYHAIVKPMKTGFRLREDTVKYAIGSCWLCAGLATLPLYIYGKYSNIDQRNLCITNLFDLFPLIYILHVSFFFVAVPFITISFCYFKIVHEVYFKNKVGPKNLAAQQETLNKRKLVKLSLSITITFVICFFPVTIAVILKSIDPRHANRSLVKYTSVLYFLESLCNPFLYAYQSTNFRQAFKAILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFC2</accession>
    <name>A0A6P8HFC2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain-containing protein Dlish-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116290743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553708.1">
        <property type="nucleotide sequence ID" value="XM_031697848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290743"/>
    <dbReference type="KEGG" id="aten:116290743"/>
    <dbReference type="InParanoid" id="A0A6P8HFC2"/>
    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090251">
        <property type="term" value="P:protein localization involved in establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039687">
        <property type="entry name" value="NPHP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15176">
        <property type="entry name" value="NEPHROCYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15176:SF1">
        <property type="entry name" value="NEPHROCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="330"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031553708.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44863" checksum="9D73B1ED4B7AF6BC" modified="2020-12-02" version="1">MAFLCPSQLTVKKKVLRGKSPIPPDSYVVNGRTDNSTPTEYKSALKSPTSSTDSSNKTSNQQRTVRIKETTTLKHETLVERKIKAASPTKPANIRVKVTHDFKSEDDEELTVHKGHYVNIIYQKHDWVYVKDSAGHQGFIPYVYCSTVNVSTDSKSSTSGYEESFEESDDVEHSGVDRNINKRGKKSSKHQHHQSRTSGKTTPTTYFPKRPYGPQMTVLYDYKARYENDLRVLRGESVMLLNDQDPEWLWVATEDGEEGFIPRTFVISHTCEGCRKKILHEQVYSPCTNGDINTSDVTVTSSSSIDKKSKESSFTDPTSSSSSNDKKYSLKGSKLIALYDFEGTAFDDLTVVXGEYVYANLKDQIVPHWIWAYSPYRKRSGFIPEEYLKEPVISDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFR8</accession>
    <name>A0A6P8HFR8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 501-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116288738</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551422.1">
        <property type="nucleotide sequence ID" value="XM_031695562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFR8"/>
    <dbReference type="GeneID" id="116288738"/>
    <dbReference type="KEGG" id="aten:116288738"/>
    <dbReference type="InParanoid" id="A0A6P8HFR8"/>
    <dbReference type="OrthoDB" id="5972065at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000226">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000992">
        <property type="entry name" value="Zinc finger protein 320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031551422.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44316" checksum="B88F30EAAC21F812" modified="2020-12-02" version="1">MGREGLVGTKQYNNDCKLSASQEIQCAKTGDFGCTNGQTTQSKEKHVKQGNRNLSKESGYLDEIEEESLPSTQQSLQEHITERPGGQDDKQRRKRENTNVKTNKCTYCNKGFKRKCHLQNHERIHTGVKPYKCKYCDKAFAQKGDLKVHERIHTGVKPYKCTYCDKAFARVSNLKTHERIHTGVKPYKCTYCNKVFTLKRSLNDHERIHTGVKPYKCTYCKKAFTQPGQLKLHERIHTGVKPFKCTYCNKAFAHQYNLKTHERIHTGVKPFKCTYCNKAFIQQGDLKKHERIHTGVKPYKCTYCNKAFTGQGDLKTHERIHTGVKPFKCTYCNKAFNRKSHLLIHERLHTGLKPYKCTYCNKAFIQAVHLKRHKRIHTGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFW3</accession>
    <name>A0A6P8HFW3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Unconventional myosin-Ie-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116292178</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555304.1">
        <property type="nucleotide sequence ID" value="XM_031699444.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HFW3">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="GeneID" id="116292178"/>
    <dbReference type="KEGG" id="aten:116292178"/>
    <dbReference type="InParanoid" id="A0A6P8HFW3"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:microfilament motor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd11827">
        <property type="entry name" value="SH3_MyoIe_If_like"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3DOMAIN"/>
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        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
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    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
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            <end position="688"/>
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            <end position="919"/>
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        <location>
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            <end position="1850"/>
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            <begin position="109"/>
            <end position="116"/>
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        <source>
            <dbReference type="RefSeq" id="XP_031555304.1"/>
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    <sequence length="1850" mass="207702" checksum="14A39E0F4C62E817" modified="2020-12-02" version="1">MPSSYHWQSKGNVKSSGVEDMVLLPKIQEAAIVENLRKRYLDDLIFTYIGPVLVSVNPFKQMPYFTDKEIELYQGAASYENPPHIYALTDNMYRNMLIDHENQCVIISGESGAGKTVCAKFIMSYLAKVSGGGENVQRIKDIILESNPLLEAFGNAKTVRNNNSSRFGKYVEIQFTRGGQPDGGKISNFLLEKSRVVMQNSTERSFHIFYQILSGASSEDKGKFGLTDPSYYYYLNQSGTYTVDGTNDSQEYEETRKAMDVIGISDENQADCLAIVAGVLHIGNICFTEDGNYAVPADDEFLQYPGYLLAVEPSLLKDKLTSRVMDSKWGGKSEIINMKLNVEQACYTRDALSKALYSRLFDYLVQSVNKAMQKDYVELTIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVEEGINWTPIDYFNNKIVCDLIETKRPPGILCVMDDVCATMHAVGEGADATLLEKLGNSVGTHQHFQSCSGGFIIHHYAGKVSYDCGGFCERNRDVLFKDLIELMQCSQNPFIASLFPDDIKSEKRGRPTTAGAKIKAQCNTLVERLMKCTPHYIRCLKPNETKRAHDWEGDRVKHQVEYLGLKENIRVRRAGFAYRRPFDKFLQRYAILTKETWPKWKGEVRQGITHLMNAVNMEKDQWQLGKSKVFIKAPESLFLLEELRERKFDGYARRIQKAYRMYKHRQYFAELKQQASDILFNKKERRRCSINRNFVGDYIGYDENPALRSLVEKRERIEFAATVNKYDRRFKPTKRDLLLSSKHIYLIGREKVKKGPEKGRVFEVIKRKLDIKSVVSVSLSHLQDDFLVLHLPDYDSVLETVFKTEFLTLLASKYEDSTSKQLKIDISGSITFSVKKEGWGGGGSRAITFSKGDSEFPLMKASGKTLNVSIATGLPKETRPGKLPTKISHSPAKPHRGAPRAPSSAAYARPHNRSRSASNAFRQSSIQPHLPSSGAQHLAKGQAQVDVHSGFMMTPESGVCGFNRSNPGPGKVQRIPNRGCVSYSAGSGRVIERVKAVRAKSVSFGESDSMQKERAQRHFEAVRATLQDAGEDTPGDVGETLQSQPQRGKYRDLDFVKAITENIQIKNASAGSKPNVQYHKDAYPPTTIEICSTDFNETCSTKKLADGIAKQRVGLSHNDGNQVFYTEYGRQRSTDDTTRLQSRTGTLPHFDCNEKTKGSRTRRLPRPATAHELTLASFASTANDMNAYKSSQMAYGTLPSKHRSCRPVTTHECTFADYYSQSYLERSMLNCRQDNGSRDFNILQKQGAQVRQATIPHGYRTASYRMAMTGQKHNKVLRDVTKLTHETISEATHLSGIEKQASCNVVSSGHRTKSKLTKNDDYVSMENLHATSPIAAKQDSVADVHYSLAHFSIDKDGREGDDARRRAVSIDYSKKSVSVPTSGTKKAPLKSILKNPTKHTEVNSKSGASTFNAKQIPHIKSSSSSSNDGNVPTVEKNGIFLTSFPVTPNKPVTEKIISKEEDFTLETAGSKNVLHHKALIHHSGDESSKTTVAECRDTNNKSPKKTFLEKTDTAADAHDVCTESVHQVIRSDSKVDDSCLDVVKPIWPAPPPPLQGALTRNTSFKCDENRATLTRSKKRRAPPVPSKDLPSRGIGDCNSQSQKTKEYGGNVTDAQTNTMEEKKKEEGGPPERNGELIKYLREIASRAMEMASDVPLDSKEKNSDAGATNPDYVNYDWYNQYYANHGINNLNASYSEDDYFSDDEFDDDFDGDDSELDETDFHESVQRDSSRKKTRPPAPNKPRLPPKPTPCLPKCRTLYPYDASDVDELTFQPGDIIEIVKEDASGWWTGKLKGKEGLFPSNYIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGE1</accession>
    <name>A0A6P8HGE1_ACTTE</name>
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        <submittedName>
            <fullName evidence="5">Nucleolar protein 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551650.1">
        <property type="nucleotide sequence ID" value="XM_031695790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGE1"/>
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        <property type="interactions" value="1059"/>
    </dbReference>
    <dbReference type="GeneID" id="116288926"/>
    <dbReference type="KEGG" id="aten:116288926"/>
    <dbReference type="InParanoid" id="A0A6P8HGE1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="HTH_NOL4"/>
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    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF22">
        <property type="entry name" value="NUCLEOLAR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23079">
        <property type="entry name" value="HTH_NOL4_2nd"/>
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    </dbReference>
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        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENPB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="319"/>
            <end position="389"/>
        </location>
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            <begin position="427"/>
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            <end position="491"/>
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        <location>
            <begin position="494"/>
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            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551650.1"/>
        </source>
    </evidence>
    <sequence length="704" mass="78530" checksum="4869F3CA82461EE9" modified="2020-12-02" version="1">MSVVEKSTFRRNFQRWVQMNYGENSRTKTITRTKYNKICRYLLGEPLIETDAKFRFWVKSKGFRIVQSEDMSLYGTLYVPVKVPHTRSMDAMYPYEESMGPRTQVLEYRRVAVADDFFDIISSVHINDRGIHVGQKKTYRAVANTYAFLPREAVSYYLMSCSTCKLRIQRCNSILLKHGRPVTPTSDLESSDAEASISSHDSDDESYSVRKLKKEPQEGLFEENGARNGMISSQRDTAETSLNGSQGHSLKEGSEDGALGRGLPPGYQTYSSDHKQEVINYAKETTVREAARKYCVPRSTVQVWCKHGTGVKKEKRSPLSGGRRLSYSSETDDKLLQWVIKEQENGTPVTKDAIQLQARSLVRDECPDFKASSGWVEKFMSRHNLAVATTMSSTNTNEAIPISYVVASPASAPSPVGGNHSSYSPRGDGRSFTSEDTRSDSGRSEEEDDMDDGSASLENMAAPISQSVIREPPNLNEILKTSGLSGSASSGLKDDDDDDGEGDDADGDAERGESGAVNPERLKAFNMFVRLFVDENLDRLVPISKQPKEKILAIIQSCQRQFPEFRDRARKRIRTYLKSCRRLKKLKEPLKRTADQMSTNPNMSAAQMAEVNNILASACASEVENSKRPRLETDSPATPPVTTTNMTATCMSVTSPAIKSRSSTQCQLSPSEIQAIRHLIQGYRESAAFLYRSADELEQLLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGZ1</accession>
    <name>A0A6P8HGZ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116289124</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116289124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551862.1">
        <property type="nucleotide sequence ID" value="XM_031696002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGZ1"/>
    <dbReference type="GeneID" id="116289124"/>
    <dbReference type="KEGG" id="aten:116289124"/>
    <dbReference type="InParanoid" id="A0A6P8HGZ1"/>
    <dbReference type="OrthoDB" id="2154780at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893:SF2">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="351"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031551862.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="60515" checksum="9187F9CF5C3B5EC9" modified="2020-12-02" version="1">MQTSLNAVKMKDETVLFCPGNCNDRGACVAGSCVCEVRYSGGNCTDSNLGYNIGFGLTFYLLCVVCFLQLVLCIWSEFGKLKRPSLAKACRPTVQKMLYICMIIACGSRGVYHSIQEYLPGWLAPNLFSVYYPIIMSGFSIIICFWAETFHVEGLQLDKPRFLSKSNIGFIIFNAFIYLLLAVQVITIEVTDYNTKVYLHNIFSGIFASLMFLVLIFFLIYGVELYYKVRGAFMTTPSSRVDCAQVTMSRLGLVSQAFFQLLISMYLMGEVMGKVWKDRLPVDSRNVLEILFRILEVAVALWFPCCLWNWKSPHQLWILNPNKLLLRQQSGENQNLLSSEKQTTSYDAIETKKGSDQECWVCYDNERRDAGDMIYPCQCKGDVAAVHHECLRRWLLELSTENHEVPKCKVCGSEYIFKLSHGRVWLPSGLNVRYWLQAVLVLAVMVTSPIGAYILCISKAPTACKVLIIGICIIMEYLCLRLMGFNMMGAYRRARLTAITIIGRHDPSTPKNNLHPELEVVEDVMHQASTSTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHJ1</accession>
    <name>A0A6P8HHJ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM221B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555306.1">
        <property type="nucleotide sequence ID" value="XM_031699446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHJ1"/>
    <dbReference type="FunCoup" id="A0A6P8HHJ1">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="GeneID" id="116292180"/>
    <dbReference type="KEGG" id="aten:116292180"/>
    <dbReference type="InParanoid" id="A0A6P8HHJ1"/>
    <dbReference type="OrthoDB" id="196393at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF3">
        <property type="entry name" value="PROTEIN FAM221B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555306.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40129" checksum="8D8CFA1E7CE4532E" modified="2020-12-02" version="1">MAESKRLFSSDLGEGLKDLSVSPQNISNSRKGHSGASGINVRGKVLKNVDKKTKPKLSSSKPVSVRPCSNQKTTEDKQAVKSKDRQSRIESSFTPKGYTSRPIVPATKAELLPVAHAMHGEDFAPRVKELFDPESKAALEAIETGIYIGWRCPDFKHDCIRVGRFSKCFCGHLLSEHRKYDGHSFRVPCALGQCECKAFAFVPSRAEEVGEFWLQRRVNFDPSTWRAKCKCKHTHEEHAPNGMKRCRVKGCRCSTFFSNFLCCACDKHWEEHETVFETAEMRKSQGIPYGESYLPFHELPELRNVVLTGKKDDNSLFEELASGPFAIPKDVPSPLALRLSGENQRSHEKHGRSQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI52</accession>
    <name>A0A6P8HI52_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555546.1">
        <property type="nucleotide sequence ID" value="XM_031699686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HI52"/>
    <dbReference type="GeneID" id="116292377"/>
    <dbReference type="KEGG" id="aten:116292377"/>
    <dbReference type="InParanoid" id="A0A6P8HI52"/>
    <dbReference type="OrthoDB" id="10283563at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555546.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61548" checksum="9798103706377CF9" modified="2020-12-02" version="1">MDERKSGKKEFQEGLGESSQNDYQRQKEAAKKAMLVANDFNSSDDTTCGERIASFLVSADLTNKDGDSKHKEAFHPSRPILWTKGKYKSRDGKSQSSQIKPFYSDMVVRRTGNDLPKSDGSLAQKTKIQRSTLHHCSITNNTDPSREVYIVEKKKAVSHKRCFESYDASTSKDEKHNANFSCSDRVSIPRMRSEKEDISSVDKKRTKDLEATSSEDWKDRQEENTEKSLNFRATTVPKKERLTVAESKKKTISGSKIVEKECKDSERDHQVNEGNRKSAKLRGAAKDPGGKKMAKTTMVIDKDELKSKSENHVSFSFTGHLPGRIPGTYSLIDIEKLKQKHSRCCRECLEARARSAAPFRKGDKEEQAKKMITGRPTAPVVAVDRASSPEEQLENSIVFFRNALNAVDLLEKLFQNIGSTKEFLQNVYDGLEESNDVARCRRNMTQAREGDEGPIQPKDIPKDDRKEKVTNENHEVENKKVVGKPKKKFHSRIRFKNNGATGQSSDMTSLKQDQKSKPKRDRDKNLLELSDEWKKRNHNAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ35</accession>
    <name>A0A6P8HJ35_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289889</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031552692.1">
        <property type="nucleotide sequence ID" value="XM_031696832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ35"/>
    <dbReference type="GeneID" id="116289889"/>
    <dbReference type="KEGG" id="aten:116289889"/>
    <dbReference type="InParanoid" id="A0A6P8HJ35"/>
    <dbReference type="OrthoDB" id="5982552at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027753859" evidence="1">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="195"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552692.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41178" checksum="51D73C7E1A216534" modified="2020-12-02" version="1">MFFLTILLLGAIQLSSCLLPSEITYKTCPKLWKKIGCSTGVHVNLSIAIDDRNKNIVDWDNVNAYEHDLLCRCRQLNLAKGHTWFGVDSQGLCLSQRGDLGSYLIQNPLEDVSKCSGPITQATLIAPDGSNCIGSQYRPFFYTIETSVPAVLAGAPVGSAPEEEMEEEEEEVAVGAAPEKEQEEEEVASCKTVADVVLVIDVSGSVKLKGFRQTQKFIKSFMDRFDFTDGTRIGIVTYDEKCQQVLDWNESAKKNKESLKKYCDSLRYTGGSTRTDLALKCAADKIVKLQKRPNVPITCVVMTDGMTWGGSNTVHGPASSLRSLGAKIISIGVGVDIDPHELKTIAGGVENNVIITDNFSDLSGPRFLNNLIAKSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ60</accession>
    <name>A0A6P8HJ60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289845</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552635.1">
        <property type="nucleotide sequence ID" value="XM_031696775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ60"/>
    <dbReference type="GeneID" id="116289845"/>
    <dbReference type="KEGG" id="aten:116289845"/>
    <dbReference type="InParanoid" id="A0A6P8HJ60"/>
    <dbReference type="OrthoDB" id="5949674at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028192280" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552635.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13535" checksum="D27B24FA4E971018" modified="2020-12-02" version="1">MKQMVVALFFVALCCVAKVQADKCYSCSSTESWGKCNGAKKEMTCSSAKCMKLKVSTEIKASGANITKTYSYIKGCGSAAACEINNNPLCKISLPGKYLMSVSASSLNSSNRHETGEFGCDVFFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJM1</accession>
    <name>A0A6P8HJM1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556574.1">
        <property type="nucleotide sequence ID" value="XM_031700714.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HJM1">
        <property type="interactions" value="708"/>
    </dbReference>
    <dbReference type="GeneID" id="116293304"/>
    <dbReference type="KEGG" id="aten:116293304"/>
    <dbReference type="InParanoid" id="A0A6P8HJM1"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="42"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556574.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36103" checksum="973727CA98A83422" modified="2020-12-02" version="1">MNSTISTANVSQKWRDFWNRSPATIAIETSILILIELIAIGGNLLVVISIYRNPRLRTITNYFVLSLAXXDILYPMLVLPISVXSSAVSRFEMGQTVCDFQGTISLILLNVSXYTIAXMAVNRYXCVCKXHKYKRWFNKKTCSIMIFGGWFVYFVVGLVVIGTGNVVYNVFLPRKIMCNLSRTTKNSTTKIIGNINSTFPILLPFTIITYCYFKVFXKIREHKRSIAPASNPNSLGTSVQEIKVTWTMFTVLMGFVLNWIPVLIVMLTTSHDKSLPRQVHMIVTYLMASCSAVNPVIYGAMNPTFRKEYKRIIKCQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK60</accession>
    <name>A0A6P8HK60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histamine N-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116290127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552980.1">
        <property type="nucleotide sequence ID" value="XM_031697120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK60"/>
    <dbReference type="FunCoup" id="A0A6P8HK60">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="GeneID" id="116290127"/>
    <dbReference type="KEGG" id="aten:116290127"/>
    <dbReference type="InParanoid" id="A0A6P8HK60"/>
    <dbReference type="OrthoDB" id="5956379at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552980.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35312" checksum="63B15FDB1DCACE08" modified="2020-12-02" version="1">MASSILDDGEYYKKSFGVFLKKTNKGEKDKEIIKLYLPNVVSKILPHHDESQFNVLSIGCGDGEMDRYIVGVIKEELQRHEKHKNTKIFTRAIDPNDHYVSQYKAYIDRSRNDDQSFFSVSQKTFEEYKKEQMSKTKQANEEEKFRIVHFIHSIYYVDPEEALAYCLEKVLHENGQVVCVVEGCDLVSNALVEMAIPVRQVRKHSPYESYAEQLKQIAEKRGWKVDLHMQIYSMDITEVFDEKSEEGNLLLDFMTKVKNFRAITEKNKVEEILKLIKELSKVTENGKRLGKRNDGIMFIYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKE4</accession>
    <name>A0A6P8HKE4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 24 25 26 27 28 29 30 31 32 33 34 35" type="primary">LOC116293026</name>
    </gene>
    <organism evidence="22 33">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24 25" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23 24 25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="RefSeq" id="XP_031556270.1">
        <property type="nucleotide sequence ID" value="XM_031700410.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556271.1">
        <property type="nucleotide sequence ID" value="XM_031700411.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556273.1">
        <property type="nucleotide sequence ID" value="XM_031700413.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556274.1">
        <property type="nucleotide sequence ID" value="XM_031700414.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556275.1">
        <property type="nucleotide sequence ID" value="XM_031700415.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556276.1">
        <property type="nucleotide sequence ID" value="XM_031700416.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556277.1">
        <property type="nucleotide sequence ID" value="XM_031700417.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556278.1">
        <property type="nucleotide sequence ID" value="XM_031700418.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556279.1">
        <property type="nucleotide sequence ID" value="XM_031700419.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556280.1">
        <property type="nucleotide sequence ID" value="XM_031700420.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556281.1">
        <property type="nucleotide sequence ID" value="XM_031700421.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556282.1">
        <property type="nucleotide sequence ID" value="XM_031700422.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556283.1">
        <property type="nucleotide sequence ID" value="XM_031700423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKE4"/>
    <dbReference type="GeneID" id="116293026"/>
    <dbReference type="KEGG" id="aten:116293026"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
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    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like I"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653064" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="21"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="507"/>
            <end position="813"/>
        </location>
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    <feature type="domain" description="Guanylate cyclase" evidence="21">
        <location>
            <begin position="886"/>
            <end position="1017"/>
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        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
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        <location>
            <begin position="823"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001436"/>
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            <dbReference type="ARBA" id="ARBA00004479"/>
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            <dbReference type="RuleBase" id="RU003431"/>
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    <evidence type="ECO:0000256" key="16">
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    <sequence length="1129" mass="128900" checksum="FAA1179156AE820F" modified="2020-12-02" version="1">MKTLFLAIVIFFLTSSHAYGKEYKLGLLIPYENVDFIIRNSYFVGQKYAAAITLAVKDVNERKDLLPNDNLTFVWKDTKCNEFTTLRHQINMIHDNLTAFIGPGCHCKMAAKNAAAFNKTMISYMCSSPELSNKTEYPTFARTFSVDTKILPTFIAIFRKFHWSKVAIVYERLQKYTMMTTYMRKEFAKRGIQVTYTAGVENQGHYDESLIYNEKKYVKEYENVMENVKKKARIVIMMTGYHMGLEGIYQANKSGMINGDYVFILSEMRPVMSGTKDKSNKLWFYLGMRSLYLRRELQAGLVITVKSPKGQRYDKFVKDLRTWTSKEPFNSDIYVNATSFFEPTAYAAFLYDAVYQFAIALNKTLAKGLPVQGSVILRQMHNISFDSIRGYQVRMDQNGDAEYNMTLKSVRMENDKLIMDEVGTFMPSGDPAGNIELVFSPGKKIHWFKKWPPPDMPKCGFDGKLCNTTKEEKKDNTHIIITTISVVLGVLAVLLIAILFRHYKVERELNSRLWKIEYNELFFDQGRRRRSEASLASSLMRLTDEGENLPLIDYPIDGEKSTSVAHYKCNVVTVARLPIRSIDVNRQVLLEMKQMRDIRHDNLNQFLGVCIGPPSVCIVMQYCSRGSLQDILENEEVKLDIVFIASLVSDVVKGMEYIHNSDLRSHGNLKSSNCLVDSRWVLKITDYGLPSIRARARKVNTEINWQDLLWVAPEILRMPIRPAKGTQKGDVYSFGIMLQEFHTREGPFSGDYMEPKSIVEKVRAGEFPPFRPVVPNLISGAEELRDMMKQCWQEEPNDRPDFNEIKKSINKIVVSSGMKRNIFDNMVQMMEKYADNLEELVAEKTVQLMDEKRKTDALLESILPRPVAEQLKKGKSVEAESFHEVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTLFDDIIQEYDVYKVETIGDAYMVVSGLPIRNGRRHAGEICRMALHLLEAVSMNFVVRHKPDYKLQLRVGVHSGPVVAGVVGNTMARYCLFGDTVNTASRMEANGEPLKIHISEVTKEILEELGGFVVETRGQVYLKGKGNVETYWLKSALKRHDSKPTLRVYTANEQPQLLNIFNTPSSSPVLIRNTNFKKSIRSRNGQIPSGKSSANQTPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKV8</accession>
    <name>A0A6P8HKV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290436</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553327.1">
        <property type="nucleotide sequence ID" value="XM_031697467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKV8"/>
    <dbReference type="GeneID" id="116290436"/>
    <dbReference type="KEGG" id="aten:116290436"/>
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    <dbReference type="OrthoDB" id="283575at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553327.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18024" checksum="3201903EAAB14CC4" modified="2020-12-02" version="1">MIVTGIISLVQPRFFPEKKEEKNMNRLGCTAQGNPLVTEWKRKNLLNDDIWVFDTKDTSSKGKYVFSNMDGFKDHTLTIYDVQPKDAGQYYCCIKNIKSPRPPEDISNCQIFGVQPQPLLQTQPPSTLTTPPPVSGFVVGKASLTFYIILLDLLLNWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPI5</accession>
    <name>A0A6P8HPI5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291537</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554580.1">
        <property type="nucleotide sequence ID" value="XM_031698720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPI5"/>
    <dbReference type="GeneID" id="116291537"/>
    <dbReference type="KEGG" id="aten:116291537"/>
    <dbReference type="InParanoid" id="A0A6P8HPI5"/>
    <dbReference type="OrthoDB" id="5954234at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028265">
        <property type="entry name" value="TTDN1/SICKLE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15502">
        <property type="entry name" value="MPLKIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554580.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="15135" checksum="A2EFA8DE02D7A9A1" modified="2020-12-02" version="1">MSGFGPPRFPHRPRGPFPFDPRFPPLNPPPRSLSPGFRPRYQENEYFRHRGRSGPRERFPTPHRHDRPSFGNRGRGQGYYGSKSFKRSSDQGRAIEAYYKHSMVEDPWKELEENLRKQNQKQEKHDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPW7</accession>
    <name>A0A6P8HPW7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosome-associated protein 350-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558414.1">
        <property type="nucleotide sequence ID" value="XM_031702554.1"/>
    </dbReference>
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        <property type="interactions" value="1250"/>
    </dbReference>
    <dbReference type="GeneID" id="116294871"/>
    <dbReference type="KEGG" id="aten:116294871"/>
    <dbReference type="InParanoid" id="A0A6P8HPW7"/>
    <dbReference type="OrthoDB" id="306254at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028750">
        <property type="entry name" value="CEP350/CC187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958:SF3">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN 350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="692"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="925"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSB2</accession>
    <name>A0A6P8HSB2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 15">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116295557</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 15"/>
    <dbReference type="RefSeq" id="XP_031559264.1">
        <property type="nucleotide sequence ID" value="XM_031703404.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HSB2">
        <property type="interactions" value="2475"/>
    </dbReference>
    <dbReference type="GeneID" id="116295557"/>
    <dbReference type="KEGG" id="aten:116295557"/>
    <dbReference type="InParanoid" id="A0A6P8HSB2"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="18">
        <location>
            <begin position="469"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="193"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031559264.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="86282" checksum="CAF2CD90BB3BDF0F" modified="2020-12-02" version="1">MPRRKVNFRKPSLEDQSDSDFDVDIETLSEDTADTESNPSYSSSPRKQDASPRRLKKSPNVTPRKGVRRSGRKNLSGGQSSQEGSKECCLCFEISDEGPPDAEDMIVCAECRNYSHQSCLGMSSNMLSIVKMYPWQCSSCKTCEKCNIRRPKCKLRVCNNCDRSFHTTCMDPNLGVDANEQWTCQICLDEPATPKAQPEEQEEEKLDAKNVDENISKPIPKTASPLRKSPKRKKTMKFVHRKRSKLKEERSKSDENMANTESEESEGGCLSDVSLSSSPAKELDYGTSTSSFKTFYVKSSSIQKKCPTQGCDGKGHLTGRFSMHHTVSGCPKYHHMTAEECKFKAEEREKEIKEKRISRKVAVDTTITTEDTPRRDLRRQVALSFMAEKVRSAVGSAELMPNNLEKYKMSPAPSRSSTVMEPVSLVAPREELKEEVLKGLTSEYDFHLFKTAWKKAAEVNEEEASIXVNGRPVCRCVVFGMFEIDTWYSSPYPEDYQRLKRIYICEFCLKYMKSPTILRRHMAKCVWKHPPGIEIYRNNNLSVFEVDGKKHKTYCQNLCLMAKLFLDHKTLYYDVEPFLFYVMTKADNVGCRFIGYFSKEKKSFLNYNVSCILTLPAYMKQGYGKMLIDFSYLLSKVEGKVGSPEKPLSDLGLISYRSYWKSVVIKYLQTYGYEKISVRDISQETAIHPNDIVSTLQYLGILKYWKGKHVVLRSKELYEEYNKKVDSRPANYQEIDPACLRWSPPVTMENNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSL3</accession>
    <name>A0A6P8HSL3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Barrier-to-autointegration factor-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Barrier-to-autointegration factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558426.1">
        <property type="nucleotide sequence ID" value="XM_031702566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSL3"/>
    <dbReference type="FunCoup" id="A0A6P8HSL3">
        <property type="interactions" value="2501"/>
    </dbReference>
    <dbReference type="GeneID" id="116294882"/>
    <dbReference type="KEGG" id="aten:116294882"/>
    <dbReference type="InParanoid" id="A0A6P8HSL3"/>
    <dbReference type="OrthoDB" id="9997163at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.40:FF:000002">
        <property type="entry name" value="Barrier to autointegration factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00079764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558426.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10169" checksum="F1AD5290862182F1" modified="2020-12-02" version="1">MSSTSQKHKNFVSEPMGEKPVTELAGIGEVLGGKLKDKGFDCAYVVLGQFLLLKKDEEMFKEWLKDLVNANKKQSSDCYTCLKEWCDAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HST8</accession>
    <name>A0A6P8HST8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116295689</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116295689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559454.1">
        <property type="nucleotide sequence ID" value="XM_031703594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HST8"/>
    <dbReference type="GeneID" id="116295689"/>
    <dbReference type="KEGG" id="aten:116295689"/>
    <dbReference type="InParanoid" id="A0A6P8HST8"/>
    <dbReference type="OrthoDB" id="5988221at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028133809" evidence="5">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="109"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031559454.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23721" checksum="A3180F8A44A464FC" modified="2020-12-02" version="1">MAARRVFLSSAILLLLLGFSLSFELSDQISDYQKFGVSFIINHGLLISGRTAYFLAGYDYLTRPRGRKYFSTRICRYPNAQITFNLNRLATSGDINPNPGPIFSGNSTNTLCSVCMKTVAKTHRAIECDLCFKWCHIKCGGVSPTEYRNLQNTLNFAWTCPTCILDLQSLPFANISNLELDDLNLNDSIHSGSLLNDSREAEANSLRDFLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTY1</accession>
    <name>A0A6P8HTY1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292941</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556150.1">
        <property type="nucleotide sequence ID" value="XM_031700290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTY1"/>
    <dbReference type="GeneID" id="116292941"/>
    <dbReference type="KEGG" id="aten:116292941"/>
    <dbReference type="InParanoid" id="A0A6P8HTY1"/>
    <dbReference type="OrthoDB" id="5977854at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556150.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23644" checksum="FFAD84B4ABFFEE3D" modified="2020-12-02" version="1">MDVDVSSSAKVTTGQTVPRMEQPFSTAREGDKTSLGAAATQELQLHANANQKAGDPRVRDVISFNKAPTPIALGNSPVDHRRTRYVFLLDDSRGTSTVKESPSGRSGGNLDLMIKHDDRLMEKMEESNRRANEDQEDFSDGGSEGSLDDVRQHPGIIKVAKSDDHEYLTLYEAHLSRLEEVGNTSSGLNDLGTVIVTNRQSVHVFDFLAMHIIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUC9</accession>
    <name>A0A6P8HUC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ral GTPase-activating protein subunit alpha-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116295223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558848.1">
        <property type="nucleotide sequence ID" value="XM_031702988.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUC9">
        <property type="interactions" value="3267"/>
    </dbReference>
    <dbReference type="GeneID" id="116295223"/>
    <dbReference type="KEGG" id="aten:116295223"/>
    <dbReference type="InParanoid" id="A0A6P8HUC9"/>
    <dbReference type="OrthoDB" id="6021142at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1741"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="903"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1969"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2044"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1420"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1970"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1990"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2010"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2053"/>
            <end position="2063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558848.1"/>
        </source>
    </evidence>
    <sequence length="2088" mass="235483" checksum="64785DB969CE8B88" modified="2020-12-02" version="1">MFHSRKNHPDIKRTTQKFLDPKKETPGRLRALRTLLDAFDSADSKVFFQGHYSEIYYVFNDMFCVVESNLKQKGHRSQKEDLDGVLYVLEKILILLPELVQKRWQFHSIGRIMLKLLHHGNAIKLRREGVRLFMLWFQCLQANSDELSQLMYASIIPGFPNPVDSIDWSKSTLSKTEAEDIVYVLHGPENEDQLIHTSLSTFHLDKSNEDWCSREEIQPIFPVATNEKSTTPDKITKFFLDRVLESMSTGVVLSEWADKRSRDHSFAFIFNNFKKFYLPYIFSNWNPRPPLYESHAEIQVPSSTVTAEDMAQDSRMIGPRESVLRWFVAFTVRFKRQNSSELSSQFLSSTKSLDSQLSSSPTSSPGSIPNIDMLRSGSSGSEHLHEASDVIRRVLYSTRENVQLLHEVLRQGFRLPPRNVNTIKQVLLVYQDWIKLQHSEKPIFILEPTPQSSHTHDVTDAPRAIMTGNEDFGPPASPVRTWSYCRAVGERERERTFTLPSEEVRAGLQANLRLFLLHSAEVFLVPEDKEFLIKQVDVCKRVIHLYRSIVLEVPMEGKTWEQLLLVLLEAAKHLLSREVPGERGSTLCGQLAAGLLQTLFVTWIRANLKVQVSTFLWDKCMDVLSSLTHWAEVINEWNTTLQTLTRVMARTVYSLDLEDLPLVRLSEQKRKKRRHQVENKTQFDKDSFTRWSKMGNHSKGSPKVIRNTLEKTNGSSAPVTPNVQRPTANAASSEVYPLDGTKKELDAAPVGNSAFYRTRKTSKIKEDALTEAADVAAGSATSNEGENAGQFSSSSALRNDLEEAKEESPLANKLLSFQMSDTESTGSGEMSFKTEPEDSINGIKDEDKTDFASTPPMLRQAATSTVTRQDTAKSMEWYNLSFDKEPSCLPKVQSETHIGLSRISESSLESKSDGGSRDSLINPVFGQDDIDIKRDDMMNMTDQMDENQGSRLSSVLTGQDISDDLTQTSYASPSPFLGETREELLEVEEVGGASEEELSVIAGGVREGWGPISSVVLWRRMLGILGNINKIKDPAIHAKVIECLTIIWDMLAKVRLNQGISIDNKFTPSVPELLPPLQYFATWVFEAASLSMPFKFKQGRLLAYQLMTAMTVRRHELPLSQEYLTHFYRLMHIGLTGTDQDVISAIISNCGHFFSLVLPCCTLLILDFIQASNTIFINQNLELPRAEAVTLMGSLLCYPNAFPNMPLHQPGHQTNEYQPTSMGKDIKEKLIVALLRVAKLDPSATTRCIALNSLGVFLVEELVHCKGHPRVQDCICILLQSITFHHKAICNVSVDLIHLLSEYYEELTEYEIDLPLKIVEVLCQTLVSLLPGGEAANVHEDHSIIVPVILCLLDWTMVIPVERLLAKKGDENLSLLTRVFQVLQMATANKISQRRRKSLNISTIISGDGRPIRLARVQDGSKTNNLLPSPLESQDSGDDSQENKTPVHFSFPPKAEPVKLTAQAALMHLVNHLGHFPLGAGPSRIDSNISEHEDNPSVPDAAEELQQSIFNSPNVQFFILNDSVLVTMIEIQEEMPTNRSVLHDMTTAKTQVRLILRDMSGRHSWDYTLLYGKNDDTGKRISFPGLLQGLSVQLQPLSPATTNKSHTRKRVLKDLRASSSPFTPDRLDEALSYIGSTSRECILYPDQSLNEPAPSSHVIDRNMEMSVIDSVSQQFESELNYINDVTDVSLSAAEFRPPSHVDPSSPFQLCRFLISENGIMAWEKRLRVDLLERNERFLRELKNLDKIRCRERHKIAVLYVADGQEDKTSIMNNSAGSQPYEDFVAGLGWEVDLSKHTGFMGGLERNLSTGSTAPYYANSTEEVIFHVSTRMPLATDGTGFTKKMRHLGNDEVHIVWSEHSRDYRYGIVNTEFGAVLLVIYPLKNHLFRIHIIKKPQVPHFGPLFDXAIVNRRVLPSLVRATAINASMAIKRALIPMYERCYEERQESIRRIVKNHKHLSMFEEFASRCFSPAPSTSSRPSTPAGDLKSFMRTQTTPSSLIEQESIRNRSKSTGNSLNGQNSELANKDLSSLAMSLPDELNRVSTGEIGTSRQEKRRLSRRWRNKSSSTTLTEIAADQNMYPEGLNCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUV6</accession>
    <name>A0A6P8HUV6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556382.1">
        <property type="nucleotide sequence ID" value="XM_031700522.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116293126"/>
    <dbReference type="InParanoid" id="A0A6P8HUV6"/>
    <dbReference type="OrthoDB" id="5978462at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="I or L" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031556382.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="38171" checksum="C3CD9BAC0FF0CB0A" modified="2020-12-02" version="1">MDLVQLQSLLRTLIAVVLLFVALQPPLRGGRFSLSQRLLPGFHGYDFRGRDXFSLISGQCWLFWRNTGETPGSFLQLVRDLTPNLFQLNVRGQPRQRQGRQKINLINQILLVLMWLRKYPHIDTLALYDIDHMSVVRIIYKVLPELWQYFHNQIRWLNDLEWANLMGNWPEFPNAVGAIDSTPHEIYRPLIEPQRQFYSGHRHYHCFNDATAYRLMTPIGTGQPLSLPRDANFLTDRAYPDGGPLLTPIXAMQMHLLNARDQRRARKFNRCLARRGIKVEHVFKDMKTYKAIANIWRHPRWLMPICIELVAFLAERRVRLFQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY77</accession>
    <name>A0A6P8HY77_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Insulin-like growth factor-binding protein complex acid labile subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116296451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560328.1">
        <property type="nucleotide sequence ID" value="XM_031704468.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296451"/>
    <dbReference type="KEGG" id="aten:116296451"/>
    <dbReference type="InParanoid" id="A0A6P8HY77"/>
    <dbReference type="OrthoDB" id="5989349at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027635722" evidence="9">
        <location>
            <begin position="21"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031560328.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57867" checksum="ECE5D6ADD677CBAC" modified="2020-12-02" version="1">MKLKPLLCLMCFSLLYRMDSTLEVCPSDCTCGYRDGILNYKSVACHNKRSVPVGIPKDANILNLFANQLEYLGPGMLTDLTLLQQLNVSRNLIGTIYPGAFYGLFDLYLLDMRLNKITHLEVGALSGPXNLKTIYLAQNFISTLKADTFKGLSRLSAMNISVNYISTIEYGAFRGLFFLRYLNIRMNRLVRLPQAAFNHTRYLEKLLLNQNLLVEVGDNYFAGLSRLKYLYLSQNYIEKISLKAFKGLSSLRKLYLSRNRIKVISNGFFEGMPRLSYLNLLDNSIVTIEAEAFMPLRALSSLLLDCNYMASFEPDLFKNTIYLRTLTITFNSFKRLQVNSLNGLKRITTLSLRFNQISEIDPGAFNKTIYLRRLYLDENLLRSLKPGIFDGLSNLETLYLQDCQITDIGIGVFKDLVGLLHLTXGYVNEENISFKIAPVELYLANSVQHLSPDSFMGLSNLKLLYLAHSSIKVLGPNSFRELSSLIELDLSYSNIEDIAPQAFTGLDGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYY6</accession>
    <name>A0A6P8HYY6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L49, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116294369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557822.1">
        <property type="nucleotide sequence ID" value="XM_031701962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYY6"/>
    <dbReference type="FunCoup" id="A0A6P8HYY6">
        <property type="interactions" value="2011"/>
    </dbReference>
    <dbReference type="GeneID" id="116294369"/>
    <dbReference type="KEGG" id="aten:116294369"/>
    <dbReference type="InParanoid" id="A0A6P8HYY6"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L49, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557822.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18089" checksum="91FFCA5395D0E914" modified="2020-12-02" version="1">MATFLCRRVLTGSCRTLGTHLAVSRDIASCIRTGLLVSQMKQKHDSANKTIEVQIDPERLKEIEESPSGWVPPTETPPDLPFFLKRSKMNNLPVYTDYKAGGTRHITVIRKIKGDLKALECLLHDKLDKDLVIQINELTGQVKIKGNHKDKVVSILKELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I075</accession>
    <name>A0A6P8I075_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase ZNRF1</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase ZNRF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc/RING finger protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">LOC116297827</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24 25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031561993.1">
        <property type="nucleotide sequence ID" value="XM_031706133.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561994.1">
        <property type="nucleotide sequence ID" value="XM_031706134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I075"/>
    <dbReference type="GeneID" id="116297827"/>
    <dbReference type="KEGG" id="aten:116297827"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000235">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031561993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031561994.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20378" checksum="7F3627F5B3C54FE0" modified="2020-12-02" version="1">MGAKQSSASTVSSRSNNRHSGPVVNGEHSRVVSLDSRTRTRSLNSVEHSLSIPSHQDSFQESDLSSSNDDSSSQLRNLGYSMQGAHSLPAQLFATSFFTGVKCPVCSKVVMSEDIELHLVLCLTKPRLSYNEDVLQMNSEECAICLDELKKGDTIARLPCLCIYHKKCLDKWFQKSRTCPEHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0J7</accession>
    <name>A0A6P8I0J7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558402.1">
        <property type="nucleotide sequence ID" value="XM_031702542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0J7"/>
    <dbReference type="FunCoup" id="A0A6P8I0J7">
        <property type="interactions" value="1931"/>
    </dbReference>
    <dbReference type="GeneID" id="116294862"/>
    <dbReference type="KEGG" id="aten:116294862"/>
    <dbReference type="InParanoid" id="A0A6P8I0J7"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031558402.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22818" checksum="5BE0C607A352DACF" modified="2020-12-02" version="1">MASGQGSKKKGLSSLMSNDPDKPVKVDKWDGNAVKNALDDQAKKVLTEGYGYQEDHSVTDTRLAICTVSVLFALGALAYDYLYPFPTSRPVLILCVVAYFVLMGILTLFTTLKEKNYILFAVEKDDAGVGPDHVWTLRSGLKRYDHMYTLTMSFKDGNSKKEREQSMIKSVACWFDTEGTLIPEHFDKDVKELRKSLGEKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2D3</accession>
    <name>A0A6P8I2D3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metalloproteinase inhibitor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561686.1">
        <property type="nucleotide sequence ID" value="XM_031705826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2D3"/>
    <dbReference type="FunCoup" id="A0A6P8I2D3">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="GeneID" id="116297572"/>
    <dbReference type="KEGG" id="aten:116297572"/>
    <dbReference type="InParanoid" id="A0A6P8I2D3"/>
    <dbReference type="OrthoDB" id="5957227at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="9" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="9" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028027665" evidence="6">
        <location>
            <begin position="24"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="42"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561686.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28269" checksum="43F261C31BF014DE" modified="2020-12-02" version="1">MDFRASMAVVFIVIVVFFSFADGRSGRRCKCRSVTHPQEFFCRSDYVFRGKLLSGPTPVSLPEPKTPKSTFRIWATERKVLRYVFQVDEILKGQTQNGLEGKIVGAGSYREIKSPYKVNVYTDPHICTVELSSKTHYVVGGYLDERRMFVSSCDWVSRWNSLSRAQKVGFRHRYGGTNCECYESSCSYLDPEGVLLDSYCRDKHLYCGRQGLGCNWKHVFASHIPYNKCVVNNIHGLFFDFAQNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3W6</accession>
    <name>A0A6P8I3W6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563259.1">
        <property type="nucleotide sequence ID" value="XM_031707399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3W6"/>
    <dbReference type="FunCoup" id="A0A6P8I3W6">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="GeneID" id="116298832"/>
    <dbReference type="KEGG" id="aten:116298832"/>
    <dbReference type="InParanoid" id="A0A6P8I3W6"/>
    <dbReference type="OrthoDB" id="10063436at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF111">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563259.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16922" checksum="4D04E4157B17C46F" modified="2020-12-02" version="1">MGRYTNYDANENQLGPEEFIIKPRKRANYDHPSANALRERIRAQNLKKAYMELQKTLPNVPPDTKLPRLNILLLAIDHIEHLMTVLSQETSMANERLPRKEDMIQPFIKKWPARCQLFSEQPAAQPTEYLPSCMYETRYPQSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I413</accession>
    <name>A0A6P8I413_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable G-protein coupled receptor No18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116298001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562201.1">
        <property type="nucleotide sequence ID" value="XM_031706341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I413"/>
    <dbReference type="GeneID" id="116298001"/>
    <dbReference type="KEGG" id="aten:116298001"/>
    <dbReference type="InParanoid" id="A0A6P8I413"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031562201.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52604" checksum="A6B7832881A61183" modified="2020-12-02" version="1">MNITSTESCQANLQAAKLSISLTLIISGIVLNVSVVAALLRRKVASLSGFQLLVVHLASADLMVFITAAPFLSMSAEYQQHAFTTAVCKGTAFSNRFTTISSIFILTAMSGCRFYSITKPFSYRVHVKSSTINVACGFLWFLSLVLSVTPFLGWGEYEQIKGQCWCALNPAKHKLNYTTVLVLAFCLPTALCCYFLVGIVVAMRNSRKTVSQKSNQAKGEVVNVNLEPAEAEAVAVAETEKQQPGQPQSPENLEEEKSNSCKAKVNLDRCLKRHQGNVDSEKPVHVSILDVLPNIQQIIEPVMTSTPSAFVVRKSSFLARKSKQTFDIEKAGNGEPESRENVFELQSYTNDTDGTNQILSQHVKLAFENSKKLRENSKKAFSILILLFCVYIAFCGPTYIIWSWFAFSDSLGSEPPRASFPVFRTMAGAQSIANCLLYGIRHREIRKEVFKLWKDIALCAKAKILKFVHSIFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4E2</accession>
    <name>A0A6P8I4E2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295841</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559655.1">
        <property type="nucleotide sequence ID" value="XM_031703795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4E2"/>
    <dbReference type="GeneID" id="116295841"/>
    <dbReference type="KEGG" id="aten:116295841"/>
    <dbReference type="InParanoid" id="A0A6P8I4E2"/>
    <dbReference type="OrthoDB" id="10271268at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027837095" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559655.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15094" checksum="873FBF534E8B88BF" modified="2020-12-02" version="1">MGILIALGWLSIFVVHSVSSSQDETIHHGIPYDATGSQEELQTDNPKESGLNTYNVKEVAKKNPKKLAHPCYAPSHMYGPTPESILINGQRFLLNTARCKSRTIFACLDNVATSLGRCQVIVKTFRGFSYTSGCQCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5D3</accession>
    <name>A0A6P8I5D3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563759.1">
        <property type="nucleotide sequence ID" value="XM_031707899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5D3"/>
    <dbReference type="GeneID" id="116299268"/>
    <dbReference type="KEGG" id="aten:116299268"/>
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    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563759.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28844" checksum="8ACD92FBE8C77D9C" modified="2020-12-02" version="1">MKVICAGLPQTGTTSIAHALRILGYKVYDYDEQILYYMNEWLDLYKHGKVPDFYAMFKDVDVVIDYPGNFFFEEIMEAFPDAKVILSEREEDIWIRRYVNNMELFASTNKLIIKMQNLIPTFKKFWFVILNLRMASLGISDPKSSYICRKRYRWHNDRVKSVVPADKLLVYSVKQGWEPLCEFTGKKIPDQPFPHLNIKGEIFRTYLTETELGRKIAQEFRVAKVCCVAVMVALIGVVLIYLFTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5H0</accession>
    <name>A0A6P8I5H0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hemicentin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116296164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559995.1">
        <property type="nucleotide sequence ID" value="XM_031704135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5H0"/>
    <dbReference type="FunCoup" id="A0A6P8I5H0">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="116296164"/>
    <dbReference type="KEGG" id="aten:116296164"/>
    <dbReference type="InParanoid" id="A0A6P8I5H0"/>
    <dbReference type="OrthoDB" id="5976503at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028283344" evidence="10">
        <location>
            <begin position="23"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Hemicentin-1-like von Willebrand factor A" evidence="11">
        <location>
            <begin position="401"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031559995.1"/>
        </source>
    </evidence>
    <sequence length="894" mass="97411" checksum="B51691F7BC7883C9" modified="2020-12-02" version="1">MMVQHKMWVVLVVLVAVHAANAAEWEPLGCYADDRDRAMPHYFKSVASSDYKHIFEECRKEAEKQGYDYFGVQYFKECWGSKQAHKTYDKHGCKDNCKVQGEYGIGTHWSNFMYHRKDDWTECSAKKCGEGVQHKLILSKDTRPNCPSYNVKIKISTETKPCSAAKPCPVDGGWSAYSTWSTCSKTCGGSGTQERTRTCTNPAPAHGGKPCSGPSEITRKCNAKPCSVNGGWSAYSAWSSCSKKCGGGTQKRTRTCTKPPPSHGGKPCSGLAEETRKCNVNKCAPKPCSVDDIVQYVLDVMPKGSVEVNNHLVGALFQVVKGMGAAGGIPKNVKVDKDEMIERIKKAMDHKGYTYARTMMGFILQKQEDCHGTGDKIIKEIKDALGEDKFKDFLAVDGDVSLVFVIDTTGSMKEEIHQAKAIARAIANYKRKGKVDYILSPYNDPGSGPVTKYTYETRSNFEKAINGLYAHGGGDCNELTFNGIINAIKVGDPLPSSPMYVFTDAPPKARGDYNRDNAIGYALDYMMPVHFFFSTMGCGNPGNNADYKAIMEDTGGLSLFFKSASAISSADALVKADLDGSTIISSGGSSSARGKRDLFGLWERGSSDVAFPVDESVANLIVSISAQSYWNNVKLVDSRGGNVAHTLDMNKGKLWLIKNPTKGTWRLSVPAGVRGLSYEIKASALSNIEFDQMFVRTLKPSGMVVPISNPLIGEKATLKLLLPHISSLNMASLKADLVNEHGVSIKDLTFKDDTATFDLPSVRAFRIRLSGKTHDGNAFQRLSREEVKPQTAIIRTQIHQSLLTIKRGVRSSFRAAIDYAGSGSKTFSVKASVVPSNLKLSVRSSVRVTNARPGYVFAYLTAPAGTPVGTVAKVHIIASSGDIKLNLLAHLMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I705</accession>
    <name>A0A6P8I705_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acid-sensing ion channel 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116296855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560822.1">
        <property type="nucleotide sequence ID" value="XM_031704962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I705"/>
    <dbReference type="GeneID" id="116296855"/>
    <dbReference type="KEGG" id="aten:116296855"/>
    <dbReference type="InParanoid" id="A0A6P8I705"/>
    <dbReference type="OrthoDB" id="5987228at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031560822.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47169" checksum="8B4ADFDF44336E95" modified="2020-12-02" version="1">MSNNEEMLKEKPESLRELAHCTTLHGVRFLAEKNVFRRIFWAACLLGATSFCVLQVKEAVEYFRSRPFSTVITIKKETKISFPEVTICNMNSIHTGKYSRQVKRLFPNTTDREIEDDISYMSRSFRVNFDSTIKTGNVSQLNRIRVMLRNLTSISYGIDDILLPKELLSCTWAGKTCGAQNFKAFYDSKSFQCFTFQPSESEVGMAGISQGLQLKMNVGTDWYLPNSYEPFVGQKVVVHPSGEYPQLDPYALLIAPGIHTSCAVRRIQFINLGTPYQTNCGEEELKYVNRGKYSYSRVVCIEDCFYKILVDRCHCKTIEMSGDLPLCLDDVQTNCILALAENMTKVDSYLKCVNSCRESCKNSLYKTKLSTAKLNSKTMANDLDDICKLKNQRLSVCEEIQNKSHMEKIQFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8A7</accession>
    <name>A0A6P8I8A7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NACHT, LRR and PYD domains-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NLRP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561307.1">
        <property type="nucleotide sequence ID" value="XM_031705447.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I8A7">
        <property type="interactions" value="1457"/>
    </dbReference>
    <dbReference type="GeneID" id="116297256"/>
    <dbReference type="KEGG" id="aten:116297256"/>
    <dbReference type="InParanoid" id="A0A6P8I8A7"/>
    <dbReference type="OrthoDB" id="5951217at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="86"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561307.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="84762" checksum="526CEA21F78A2DFD" modified="2020-12-02" version="1">MLKEAIKXNTENQTKFMAAHDVPSAKTDEIFTNLTVYYADKKQEKKEQAKDLGRSKRLKGYTKSRMTGCKVEKYEDIFIDMKGENPKLLLTGKPGIGKTFLCEKFIRDWSMNRIFQXENTPNIQFAYLLKFRQLSLQGDKXMNLQELLNCSPLLDHNSVINDSLFEHLIQNPSKVLIILDGFDECSEQHRKQITSNFEKKYPNDSKKEMPIPALCSKLIKGIFFKNSVVLVSSRPGKAEKLGKVQFDRYVEISGFSPEQVTEYVDKYFSEKEQTKKVVREHIEKNKNLISFCHIPLLSFLLCWCLEWRISRSGITENLPAKITDLYDDVAKVLVQKLHANLKYSEMSEYAKQIAEETLDKLAKLAANLLKESKYIFDEEDMKKLDLTDDEIENLKVSGILHCVPGIRITPFETKAEFSFTHLTLQEYLSASFFVKNNEIPEGMSEQTLVFMCGRLSKIKDGEQLMSKLIQQIAPECYPVEYNKVLVLQCLYEYGERELTSTIINDRYQFGEICFCRATDAEVEYLTFVLDSIRSLKEQQQSSTLNISQSSLTLFGVGVVCRSLVGNSFITKLDLSECSLDDKCVEKITESLENTGITHLDPKYSEITDEGVKSICSVLTQTKITHLDLSGNYIMDEGAESICSVLTQTKITHLDLGDNNITDEGVKSICSVLTQTKITRLDLWNNNITDEGAESICRVIIRDDCQVEYLDLSDNNRITAECKERVKQLVKKHKPGVEFHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8S4</accession>
    <name>A0A6P8I8S4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297411</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561492.1">
        <property type="nucleotide sequence ID" value="XM_031705632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8S4"/>
    <dbReference type="GeneID" id="116297411"/>
    <dbReference type="KEGG" id="aten:116297411"/>
    <dbReference type="InParanoid" id="A0A6P8I8S4"/>
    <dbReference type="OrthoDB" id="5962291at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561492.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19071" checksum="D7BA09A63951A39D" modified="2020-12-02" version="1">MASEPNDTQMQVERLTNEIEDMPRDMAIFSLCLKSLFAEGAVGTNAEAAVKFRKLRDDTRNDAMVYLKVVLPICVEFVASISEFFEYYETLDYEEWCDKLEDILEETTACKQLCETITKMHEDILVPLKKRQDQANLVVQELKDLQLEFERKKKELEKSADEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I906</accession>
    <name>A0A6P8I906_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116300336 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565049.1">
        <property type="nucleotide sequence ID" value="XM_031709189.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116300336"/>
    <dbReference type="InParanoid" id="A0A6P8I906"/>
    <dbReference type="OrthoDB" id="5989160at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027833518" evidence="2">
        <location>
            <begin position="26"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="563"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565049.1"/>
        </source>
    </evidence>
    <sequence length="725" mass="82457" checksum="0144B9BE4C06CE74" modified="2020-12-02" version="1">MYLRXVLTAFCAVFIIIFSCSVTNARKEEKRKLEILHAGKSLEELVSLGAHVDPHDITVNGLAETIEPKLMEETHQERLMLQQNGIEDPYPLDATIEYEHKKKLPKPIIATENNPKDKSSFSYEDPEDTRYDSNDMPEYDVETKADFTANQEAADWLMHDPNRFNVMPDEDTKNLFSDDKESNRKTNDDPIRLDDKDKQDSGYQNLNNDDNQEMYAKIQESLAPDSNMEKIYSKYEKFLNKFDQKLKGINKNVKDENDFSDVGNDVNNVAESDVTTDEDSDENENNADPDANSQRINVMTSLESSFEGDDNKAKTSKVKEIVSDEESKIKLLKHLQEKIKMNEEKEIENRKHEKDSTASSSGNGKINKADSARHDNKLDDQRNTSSGKSGSFPSDESPTNVLPVFRISHLHKPITESQERDVSPRVGAXSTEKGTSRQNVDINRGSFGMSRFSRLYPSNKYGGIAQMMLSTPSYEQPRVQGIXSLVHASQKMPRPQLHPQDPEDGKGRHGIPTRFGEWNGWSECSVSCGRGSQIRARICLQLPCQSRDLYQTRKCTRNICPGKWRKESLKAHNIIRALHHSPPLVWSNSLAQKAKQLADNLASRDYIGSQDLHEENGENIAQLRDIKGSDSLAQKAVDLWYNEIKSYSFSYPEMNRENKHFIQMVWKKTKTLGMASTQSPSGEYNFVVALYGGPDIDNKLLHDNVFRAGQKHDVYTTFKRSRGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I912</accession>
    <name>A0A6P8I912_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multiple PDZ domain protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563716.1">
        <property type="nucleotide sequence ID" value="XM_031707856.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299227"/>
    <dbReference type="InParanoid" id="A0A6P8I912"/>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="529"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563716.1"/>
        </source>
    </evidence>
    <sequence length="650" mass="73227" checksum="1A0E4E4CB7712B6B" modified="2020-12-02" version="1">MKAPNFDLSSLSFVSKARKFLKSRNSTTERRDFKAISFSNEVYQETCRPVKNREESSTWRHPLTIWQKNNTEKSNAGETTTPRTSVRSYKYPWGRKDDGEVVKKEESASTNEIQKDEGIFTVELVKPHYGYLGLVLVGGADTPLQKHYVKEILPDSIXDKSGSVRIGDELIEVNGHTLRGRTHSSALVVIRTLPPVIKFLIERSKDGNKGILSSFASEEPETDSGDPDITSPKARSRKRSVLQMANDSCVIKKSVSTVIDVVSRNIPSPLVKPAKLVRRESKCTSFVGVANGDDDVKSCKGGESVKDGVVDEEANDYDDRLSMLSNTSEWCARQMTMSTPSQDSTIQNDDLSDVMSTFSMSTLSESLPEPFTEEALDRHEEYVPCYQSTPLRHGSLRKSRVLTESIIEVDSDEDEEKVPSEPKMFLRRGSLRARGSLALRRVSCIEDEEERATWPTSTRRQRASLNWDTFVPPPDRPVRRSSSGCIRPSSMYTNNVPSGKTSEQAKQSSRRLQRSNSTGKYIDKQTLRTKVYRKQNTGGWGFTIAGGVCSPYGDLPIHILDIENSTTAGGSLLKKGDEIVSFGGENFENITFLEANRKMRNFEENXATVIIKRKYLHRKKMQACSTFAEAWNEQARQSQRIRQRPESFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9B7</accession>
    <name>A0A6P8I9B7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116299231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563831.1">
        <property type="nucleotide sequence ID" value="XM_031707971.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I9B7">
        <property type="interactions" value="3807"/>
    </dbReference>
    <dbReference type="GeneID" id="116299231"/>
    <dbReference type="InParanoid" id="A0A6P8I9B7"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563831.1"/>
        </source>
    </evidence>
    <sequence length="1070" mass="123804" checksum="2A2C14F79037B065" modified="2020-12-02" version="1">MPTAMATIEQAPQLLDFSQKLDINLLDSVVSWFYMSQGPQQKVADQILTQLKQHPDAWTRVDTILEFSTNQQTKYFALQILEMVIKTRWKILPEEQREGIKKYIVGLIIKISSDSSELEKEKTYLGKLNMILVEILKHEWPTKWPTFISDLVGASKANESLCQNNMTILKLLSEEVFDFSSGQMTQTKSKHLKDSMCSEFSQIFTLCQFVMDNSQNVTLVESTLETLLKFLNWIPLGYIFETKVISTLIYKFLNVPLFRNVTLKCLTEIAGINASQYEGQFVDLFSLTMAQLKQVLPLTINIRDAYANGRDDEQKFIQNLSLFLCTFLKEHGNLVEKKVDLQTTLLEALHYLVLISEVEETEIFKICLEYWNTLASDLYRENPFSSTSNPLLIVQSQQVPPRRQLYLSVLTKVRIIMISRMAKPEEVLVVENDQGEVVREFMKDTDAINLYKNMRETLVYLTHLDYQDTERIMTEKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEIKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCKRHFVQVQVGEVMPFIEEILNSTQSIICDLQPLQVHTFYEAVGYMISAQTDPVVMERLIEKYMSLPNQAWDNXIREATRNIDHLKDMEVVKQLGNILKTNVRGCKSIGHPFVTQLGRIYLDMLNVYRCLSENISLAITQNGEIVMKQPLIRAMRTVKTEVLRLISTWVNKSNDPKLVCDNFIPPLLDAVLGDYQRNVPRAREPEVLSTMATFINKLENHITENVPQIFDAVFECTLEMINKDFEEFPEHRTNFFLLLQAVMQHCFQALLKIPPEQFKLVLDSIIWAFKHTMRNVADTGLQVLYTLLKNIENESASQSFYQTYYIMIVQHVLSVVTDTSHTAGLTMHATILAHMFSLADSGKISEPLFNASEVQYPSNEAYIQSYIMDLLKQAFPHLRDEQIQITVKGLFQLDQDIPAFKEHLRDFMVQIKEFRSEDTHDLFLEEREVQLKSAEEEKRKVQMTVPGIINPHDIPEDMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA85</accession>
    <name>A0A6P8IA85_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Degenerin mec-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116297514</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561615.1">
        <property type="nucleotide sequence ID" value="XM_031705755.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IA85">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="GeneID" id="116297514"/>
    <dbReference type="KEGG" id="aten:116297514"/>
    <dbReference type="InParanoid" id="A0A6P8IA85"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031561615.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="70914" checksum="F632CABCF1B66627" modified="2020-12-02" version="1">MDGLESPTQETKMNPKTKSSTLSVIKEFCDYTSIHGLGRTAGAKHLLQKFVWLLLFLGALGMAVFQLRELYLKYESRPVSTIMKLTNKATLRFPEVTFCNINPLHASLVQEITPELYREIMSTKGENMIDDEPMSWPSLSGDEDNENNQTSPDTTSTPPPTTSSHLNTSIDSDEDHEKDDFEDQPLLRKRRSQGESNEQGRLGEGNDNDSDDNEDGEDSKSDDDNEGNGDDDYYDYDDVDDEDDFPVNPSELLASHKRQQLIYQFISEIGERVGYKIGHQFHDSVLACSFRGMDCKKKMIQYWAKFWHHKYGICYTFNAKAKSFKPLKSNKAGPSHDQANYMSEFTRMAGYKIVINEQGLMTFPDEEGINVPPGVFASIGMRKVHIIRADPFNNNSCFDNKKQSNEGNLYYLQYRTKYSNNACRESCLXYNQRKYCNCSEYRFPFTDNTPACLMFNITHAKCLRNVNALFKDNKLNCSKECTPPCKEDYYRLSPSFAAWPSKKYEEEIFKGKNEDLDRKIHFSDNYLKVSIFYEQLNYEIIEETVSYGVIDFVSDVGGQLGLWLGVSVLAATEVIELMMLIVIFLCKKGEKPERGMMNEDKTFYLQEELKLSNISSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBK2</accession>
    <name>A0A6P8IBK2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gremlin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116298525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562882.1">
        <property type="nucleotide sequence ID" value="XM_031707022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBK2"/>
    <dbReference type="FunCoup" id="A0A6P8IBK2">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="GeneID" id="116298525"/>
    <dbReference type="KEGG" id="aten:116298525"/>
    <dbReference type="InParanoid" id="A0A6P8IBK2"/>
    <dbReference type="OrthoDB" id="10061784at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF4">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028339993" evidence="6">
        <location>
            <begin position="27"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="7">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031562882.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21644" checksum="5F75FE90C4FDDE6D" modified="2020-12-02" version="1">MLVVPKSKTGIIILLIVMLKASLNNGRSLSQDSLYSTNDLESQGSMRKVPLQNKFPLSPKNHMPSGTSVVVQPSSSSATSQKTHNKKFPLKGGSTLLVLPFLRTAIPKDWCKTRKFLQKIHHHGCNSTYITNNVCVGQCLSVFIPNHFVSCSYCTPVEKNVISVELKCPGLQKPVVKKVSIVKSCRCMPCRKNYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC84</accession>
    <name>A0A6P8IC84_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116298842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031563272.1">
        <property type="nucleotide sequence ID" value="XM_031707412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC84"/>
    <dbReference type="FunCoup" id="A0A6P8IC84">
        <property type="interactions" value="2893"/>
    </dbReference>
    <dbReference type="GeneID" id="116298842"/>
    <dbReference type="KEGG" id="aten:116298842"/>
    <dbReference type="InParanoid" id="A0A6P8IC84"/>
    <dbReference type="OrthoDB" id="10016527at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06607">
        <property type="entry name" value="STKc_TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000030">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="859"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="428"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563272.1"/>
        </source>
    </evidence>
    <sequence length="897" mass="104938" checksum="B3D0CC510224A8E1" modified="2020-12-02" version="1">MPSVKVALFKNPEYAGLFDEHDPEKLYADLREIGHGSFGAVYYGRNVKTQEVVAIKRMSYSGKQSQEKWNDIVKEVKFLKQCNHRNTISYLACHLKDHTAWLVMEYCLGSASDILEVHKKPLKELEIAAICADAIEGLKYLHSHERIHRDVKAGNILLTEDGTVKLADFGSASLASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITSIELAERKPPLFNMNAMSALYHIAQNDPPTLTTSGWSEDFVHFVQSCLQKHPLDRPSSEQLAEHRFITGRRSNGIIKDLIHRTKAAVRALDKMNYHRMKKMIMSDVPGEINAEGTSDSDSISPYQDTDDKDPQTSALEVENKGASVKSSVSSRSSNESLQDTETEDDKSIIHRHVAIERQTAERDDRFATIRPKNVIARQQQEHRPGADRMHDQLMVYKRMRQSHQRQLEILENKLRTEMNDHRRQLDKEYEQMVHQFEKDLDKIRSRHKVELDQKCKQMQSEEKKLQKQIRDQQDNEIKIFCSKQKAEYKAAKSSFKKNNPALYQERKDTFQATQNKILQQKRLAQREYLRNERRRFLRQQMNQRHILENDLISEEMNKLEAQKEQSHKMLIRHHESTQELEFKHLSALHKLRREQQQYQHTTEWNNQMEYNKQAELDLRKKHLFELKQQPKTLKQKENEIKKQYRDAIRTQTSQYKFLQKQTLEKAPRDQHKDIIKQYREDRMRKMADLAVQYDQSIAEMLQRQTLKLDEVQLCEQESLRQKLQSEQELLNAYQSKQSNQLKLQHDREEKELQEKVSVRRALLEQKMFQETEKLQQLRRDKTRQLEERHTRELEDFDNDADPDNYSTASWKLRSISSVTSLSNLSSSSSVSASSAQGTNENNGALRAQPASNERLTVNSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICA2</accession>
    <name>A0A6P8ICA2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116298867</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116298867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563302.1">
        <property type="nucleotide sequence ID" value="XM_031707442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298867"/>
    <dbReference type="KEGG" id="aten:116298867"/>
    <dbReference type="InParanoid" id="A0A6P8ICA2"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0420">Kringle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028057845" evidence="6">
        <location>
            <begin position="18"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="8">
        <location>
            <begin position="166"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="676"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="877"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563302.1"/>
        </source>
    </evidence>
    <sequence length="990" mass="112778" checksum="0DADAA5CC694F158" modified="2020-12-02" version="1">MQKVAIQLLLVLASVNGFLWDKEIEVIKSEWSPVVVVIRHVEYIGRQDNGTLDCSVPGFTNYRWTVINKATMEGFTESYVLGTGSKRIPESQSHLTIGEGGFDLLNDVLAVSCEALIGLHPRMQIIWAITRLHSPMGYPTDPRVCDFGSTSLETNCLWYQWTYKKDCYYDKGMEYTGSVNMAKHNKCKYWHMGTGPHKRSPVIARLMGIFDKGGHDYCRNIPWNPTCYLKKGEDPSCKENVLTQPWCYSDDDPNEGEFKVHYCDVPECSSCMYGNGDGSFKLYPGRKFPVYLGRNIETTKITNKNRVLCRQGIGWQDNVCRVKLSIRTQEMGAPHVVTKATPHCYVAKPGTDVNKIKKVPDQNLELVECKFKQCTVRQVWFLFFNTYGNPFVVESNFDGIKIELVRGRKEERIKFAAFGIHLVSGLIIESNDNRVTSYLDNFSLITRRPPEKLSELVVKNVRKEYSGLYQLTYKFAEADPAVDQGTYKVNFEIDVKEPTSFSLKPSVLKVCANGKGKLRVEVRGYFQVLEDTIKWKYGLSRMSINTEILPQNTRFELSADAKGLSIKTVTEDLWVSXEGRSYSGKPKAIAHVTLKDQPFLKSVSPTTQYTLPGDDVSLIIENDQLQKVTWRFDAMEISSLPDDPNMGFRRVPRGDHIVTSLVISDVREHQYGSYYVETEMDGCKSTVKFDVKHLSEKPDTDQQILIKNKVKPVDFNRTGLWCTDELDPYAFYFDIDLNDVTTIGALRNEPLTHSNAVEVQHYTIQYSIDRRTWNTLILKGNESKIPYTLLGNEIYWLNKSITTRYLRLLPETTETTTCMRVTLFGCEGDTLDCDIIPLSSSGLGIKNLGIYLGIGGVLLSLSIAVFVLIRRSRLSDEENKKRKTKKRGREDNSTCKKPRKREKPSGKKDICKGKGKLNHPGLKNKGKKKRHIDSFDENWNSEVSGTREMKKRIPKRHIKEDGRKPGNKVQERARRAGYAVDGDSFYGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDY9</accession>
    <name>A0A6P8IDY9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTP-binding protein Di-Ras1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116300105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564737.1">
        <property type="nucleotide sequence ID" value="XM_031708877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300105"/>
    <dbReference type="KEGG" id="aten:116300105"/>
    <dbReference type="InParanoid" id="A0A6P8IDY9"/>
    <dbReference type="OrthoDB" id="5968470at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031564737.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26398" checksum="FECC45A6FB274A15" modified="2020-12-02" version="1">MATTSLRHQDQDGLNVETRKFTIVFFGDSSVGKTSLILRFLGYGFSDEYQPTIEDFFIKHVXYNNKTCELQLIDTTGTYEFPAMRKVDILKADAFVLVYTPNNPVSFKKLSRYRSEILEEGKDKCPCIVVCNKSDLGRDVQQPILRDHRGMQVSVQHLVENQWRCHWMDCSAKENYNVELIFYRLLDDICKLYQTETPLRKISSLLQLRKKSVSKQSLASLDHENTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG69</accession>
    <name>A0A6P8IG69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 17 member 9-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565729.1">
        <property type="nucleotide sequence ID" value="XM_031709869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG69"/>
    <dbReference type="GeneID" id="116300900"/>
    <dbReference type="KEGG" id="aten:116300900"/>
    <dbReference type="InParanoid" id="A0A6P8IG69"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000059">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF279">
        <property type="entry name" value="VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565729.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35995" checksum="551178C09A718697" modified="2020-12-02" version="1">MRYPAFPARPKLSFIMMKSLDTTDKELNDQWQGGKRRVWIMAMFVGTMFLYAARSAVPLCMAAMSKDMSWDKEADGAVMSAFFWGYTPAQIIGGWLSDKYGGELVLGYAGIVWSLCTMIVPFLPAGPTLFFPPIAIMVISRVFTGLSQGLHYPSLTNIIVKRIPLKERSLFTSSIFSAGPVGTLLMGSAGSIVLVLFGWHSVFLLQGLVGLTWAWLWRYYATGQYTPTRTELSIGNIKMTEATVSEKAARVSVPYSTFFKHPGVWAIIISQFCQAGAFWILFSWLPLYFEEVYPNSKVLHCNTYQTSKKIIFIFHISADNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGV1</accession>
    <name>A0A6P8IGV1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZZ-type zinc finger-containing protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116301107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565971.1">
        <property type="nucleotide sequence ID" value="XM_031710111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGV1"/>
    <dbReference type="FunCoup" id="A0A6P8IGV1">
        <property type="interactions" value="1717"/>
    </dbReference>
    <dbReference type="GeneID" id="116301107"/>
    <dbReference type="KEGG" id="aten:116301107"/>
    <dbReference type="InParanoid" id="A0A6P8IGV1"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="348"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="349"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="516"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565971.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="68293" checksum="CB757C74267B812E" modified="2020-12-02" version="1">MACVREAIDRCGETFGKELGVEEEEIDIIGITSEKQGDENSRNQLNGKVEEEEKILNYEELLSSKSEEEINQANHCSDKNHSCEAEKNATEIKDKLESNISTTSDSDVNSLKAELTRIDNYTCNDCSSNSSASSSTKSSRRSSISSTDNSKKQNEKQETFVNESGIMGQYSQLSDYEDDDFKSSEPYERFFFESDYLALKDNKHYCLLLQTLVALEAQRIQAIKDLDQLCEEEAKALDDPIEFVEKLQNNEPLDLPAAQNVTKLPNIPWEVYASSIGSLENLSAHPNTRATANHVEKVPQLPSNFANDSASENISPSNRGSEMIFSVSAENNILEESGHSSKLRTFNQPWTTEEQTRLEKLLQIYPQEEVESKRWEKIAKALGNRTPKQVASRTQKYFIKLARAGLPIPGRVPNVPKAGSRLNRRSNHYSTIGFRNSTFFPSYQPRVYMDDNNDDDDDDSSVGFSDDISCLSDDEVIPEELRQTNEYKELLQLKNIKRRKLHHVDQQQQQQTSTVHSGYMCDGCGVSPITGPRWHCQDCPDNKSVDFCSFCIEKGIPESRSHSRHHRLELVSKDSCFFVDGDYVGMSGSTTGYNYLDPNFLPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHB9</accession>
    <name>A0A6P8IHB9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301231</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566119.1">
        <property type="nucleotide sequence ID" value="XM_031710259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHB9"/>
    <dbReference type="GeneID" id="116301231"/>
    <dbReference type="KEGG" id="aten:116301231"/>
    <dbReference type="InParanoid" id="A0A6P8IHB9"/>
    <dbReference type="OrthoDB" id="5965074at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566119.1"/>
        </source>
    </evidence>
    <sequence length="946" mass="104486" checksum="E510106BB533B1C8" modified="2020-12-02" version="1">MASAFGDQSYSKLPPIRKGSNESQHHDEGKETDSSHLIDFNREGHGLVRLPPIIRVDSSLNTTKQRESPTSVICSENKDSFVSSRRLSTDLTSKRKLYSSQSDLQLHEARRADEKRKLDENTTNDSSDNYTRDSHLVKSDTHGCTIPRLEIDTFWENNLNDSKATSLLNTRQVDRNSRRASLIAAEPQKLHRSRRLAKSSPELSSTRKKYNSPIKESKVASKGRADVESIAASCSASDSKNEQLQFDISVNISSKDQESPRSPRNGQGRGIARRTEYKHKASTKGDFLPYSSPSTPVVHLMSDDNLSPRGGRQSLGDINNILSPQRARKTSIVSTRKKIPIRDELKKESALRVDGKTCPKNERLTSRATSSFRPHQMNKDGFLRPPESRTKRDSLYDLQQILSMLNTEDKSSNPSDSSKRENRSSSVYDLQEFLKMSSFGEQPASVTSNSKQSKHSSVGAESLLVPRLVEPGNRRGSTYELLEFLNQLNLAAAKTKGPPGKGSENTTVGQKQTENAPFLSPGDSENTSTQRRPSAYDLMEFLSLSRGSQNEETTNTDGTSQTQPVLKLRVNAGSEQGETRKASVYNLEEFLGIPKNVPTTGSMVCDSEATPTPNTPLLSPNFASKFKFKRESIYDLQEFLGILQKETDGKQNSSQATDEDKKTSKPIEHPGMEHHPGKEHTDTLSGAEPQKNRSLSIYDLREFLSMHASQSQSQSQSRGRKASSISQTSIMINVSEDEFGNGSVDDVFLAVPVEGALARKRSSVSELSELLNILNDPSRKRIHSNVSSAKSTSSERSSVAPPSPVSRHDSSGAKSLYDLGEFLSVLNSDDSPLRRRLSSVSDRGNCTPSGLSRHDSSGGSSLYDLEEFLTILNDNGKEENESMEENNGQEICIPVPQLPSRSERNGSERMTLVKRTSLTALNSLPESTDIVGKAEEGRRKSLGHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHI6</accession>
    <name>A0A6P8IHI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Fibropellin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116301282</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566179.1">
        <property type="nucleotide sequence ID" value="XM_031710319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHI6"/>
    <dbReference type="GeneID" id="116301282"/>
    <dbReference type="KEGG" id="aten:116301282"/>
    <dbReference type="InParanoid" id="A0A6P8IHI6"/>
    <dbReference type="OrthoDB" id="5948426at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000334">
        <property type="entry name" value="protein delta homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028028099" evidence="13">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031566179.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="26889" checksum="E80E6D6F148B6682" modified="2020-12-02" version="1">MIFLGILLIALAGSQLADGQLLYCAFNPCINGGTCKEVVNGFECQCAPGWTGNNCESSIDDCRPESCINGATCIDRHLGFRCNCILGWTGKHCEININDCIPDPCLNGGTCCCDRLNSFTCNCLPGFTGKICEININECASNPCQNGGTCNDKVNGYTCSCPEHFTGSHCEIEIDFDECGSNPCQNGATCTDQINGYLCSCPTGFQGSECQINIDDCAASPCMHGGVCTDLVNNFNCKCPNGWMGKKCEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJA6</accession>
    <name>A0A6P8IJA6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301857</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566879.1">
        <property type="nucleotide sequence ID" value="XM_031711019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJA6"/>
    <dbReference type="GeneID" id="116301857"/>
    <dbReference type="KEGG" id="aten:116301857"/>
    <dbReference type="InParanoid" id="A0A6P8IJA6"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF1">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="332"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566879.1"/>
        </source>
    </evidence>
    <sequence length="667" mass="74924" checksum="2C5B7836E3FE259C" modified="2020-12-02" version="1">MWEVSMWQYFTATIVNFNARTLKFEIIWDDQDPSGRIIDYYNLALDRVPDDDEVAVGSIVLFPQGEYRGEEGVRLGGQRWHQGKITFVSKGENGEKLYSGQHTKGKEDGKWVTFRGYEPEFYSLTRNQLRIAPNVLDLLSAEASNDEESVHDTNEDAADSCDVFISYSKLNSLDAVRNNEVGNQDLPPSYNEALAAMCDPHDIRNQLQQNGLLVGQEPSGDLMKTVKMIHNAKVVIAFLSDEYANDEICRQEFQYAKKTAKKSVIPVVIGESFEWMMSVVGLLIAGELYIHFKDKTVQEMKMQELLKAVGKSVPTGADTTDAAVTSVPKKLPTPDVFVSYCWSNSNKALQSHQIPKLVGSQFADARRIKEDLSKSGDLVLWLDIERLQTTNQSAESMSMFQQIASGLNTAKVVIVCVSAEYAKSDNCRSEFQFALKSLKKPIIPVVVGEGSDWRDTVIGLLVSSQETEIIDMQSVTTEENYRNALEKIEKNVKAILGTKNKTKEKKDFRAPMPGDHVICHHHKWAFYYATIESFNAETLEYTVNWDDNDPSGRHETYKNVAIDTIPSPDQIGVDSIVFFPQGSYGATLGNNTGGGRFHQGRITNIHKDAFGVTLYDGHHTKGDDDGKWVTYKDYNYYFTNLKIDQLRIAPNAMDALMACKQAFSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKI7</accession>
    <name>A0A6P8IKI7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuronal-specific septin-3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116302183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567267.1">
        <property type="nucleotide sequence ID" value="XM_031711407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKI7"/>
    <dbReference type="FunCoup" id="A0A6P8IKI7">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="GeneID" id="116302183"/>
    <dbReference type="KEGG" id="aten:116302183"/>
    <dbReference type="InParanoid" id="A0A6P8IKI7"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="115"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031567267.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46453" checksum="FF6DA066E05A5CB2" modified="2020-12-02" version="1">MADKRFMLTGAQRDALSKVFKFADVEETGFVDVATISTLAVQLLGAQLSDNEKDTITSKAESKAEKGLLSYQNFIDIMMETMQAMTHWGKLKTPLDGYVGFDTVQEQIRKKSLKRGFEFNLMVVGASGLGKSTMVNTLFKSKLSRPSATGIPTTIPKTVDVKSVSHVIEEKGVRLKLTLTDTPGFGDQINNDKCWDPILEYINDQYDKYLEEETSISRKSRIPDTRVHCCLYFIAPTGHRLRPIDVEFMKRLDKCVNIVPVIAKADNLTLEEREAFRRRIRDDIEANKINIYPMVKRDDLDEEELRVNSRIRDQLPFAVVGSDRFVTVSGKSVLGRKTKWGLIEVENKNHCEFSQLRDMLIRTHMQDLKEVTNSIHYESFRKIQLTEQQKNRIDISNIDDTQESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKR3</accession>
    <name>A0A6P8IKR3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116302255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116302255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567347.1">
        <property type="nucleotide sequence ID" value="XM_031711487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKR3"/>
    <dbReference type="GeneID" id="116302255"/>
    <dbReference type="KEGG" id="aten:116302255"/>
    <dbReference type="InParanoid" id="A0A6P8IKR3"/>
    <dbReference type="OrthoDB" id="5988065at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028229113" evidence="4">
        <location>
            <begin position="22"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="237"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031567347.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46130" checksum="915937C1897B3FB6" modified="2020-12-02" version="1">MYPWCSFVFVILLHTAVENKGSPPTWPYGEYTLLKPRTGCPAGWDDKGYIYQDTIDKNPSNNRSQTLHIDGKVACSHVKRHFCSKTNTDGEVWPSGQYCVYRHEKEKLHRMRPGSILMYNEKNNNKDEYKLTKFRVYIKKIKRSFIYMKLYFACQTSGDKKIPISLPITKPFYLLPHGSRDCQQVKWMVATTEWIKYHTNNYIKKGGKQTYGKVPYHELGDRKHQGITMFYCYYESCKYTLIDTRGVFQSPGFPGEYPDGQLCSWRIMVPVNHTVQVRFTNVSLNDNDTLRYSERYSTRSNGSFRSWHTIPLNLSVPFTLLSDSDVLFVFSSDESKTSSGFRAEYHHGSIPQATTTPTETSTASTASTASTASTATPSETSSIPLTTPHSELIEGLVKQAEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL29</accession>
    <name>A0A6P8IL29_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fas-binding factor 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567504.1">
        <property type="nucleotide sequence ID" value="XM_031711644.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IL29">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="GeneID" id="116302366"/>
    <dbReference type="KEGG" id="aten:116302366"/>
    <dbReference type="InParanoid" id="A0A6P8IL29"/>
    <dbReference type="OrthoDB" id="8195456at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033561">
        <property type="entry name" value="FBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049390">
        <property type="entry name" value="FBF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33689">
        <property type="entry name" value="FAS-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33689:SF1">
        <property type="entry name" value="FAS-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21007">
        <property type="entry name" value="FBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fas-binding factor 1 C-terminal" evidence="3">
        <location>
            <begin position="838"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="796"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="1018"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <end position="183"/>
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            <begin position="506"/>
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            <begin position="537"/>
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            <begin position="641"/>
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            <end position="669"/>
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            <begin position="741"/>
            <end position="752"/>
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    </feature>
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        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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            <dbReference type="Pfam" id="PF21007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567504.1"/>
        </source>
    </evidence>
    <sequence length="1387" mass="155701" checksum="67314577CD513B6E" modified="2020-12-02" version="1">MKKSGDPFGRPATKGRSTPMSLGKSQASKTGRGSKLSTLTSSATDEDFYSSLADMAGDNFHDDDEEESMTELDAKNLADTLEGMDDLDSDLFGDSLRRKTSTKNVSNTKPTTTSTPSKNKLSNTATSEKQDKTETRDDTTRKTAEKRGSSSSPTGKKFSLNKYDNLDFDEDDPLAGLLSDDEDAATKSKAKKKTAAAKKTPVKKEPEPVAVSAELERPTTSRSQQRQESQSLDLQSPPLSPNTKTQNRQETASPKSVKFSDRISSPTESQDGSLAASPRPKGRQSQSKPKNDVSFDDDGDDLLPGIDQSPRQTPSSRQTSVGQTPSTRQTSGTPGRRREQKTDSDLFGEDDGLLGLDEGKPTAKQTNTKASRFDELLGGKKEKIEPKPQKPKTLDDFMSNISTSSGKKSTETQPKKALSSKEEEESFQFGSYTPSAAIGPGGPGSRPDTAPGRRSVRFADELGLDDDLLGGASRPSTAPPERKQATQGKGRRGMKDSGGSSFDEDSTQKEPHKKEATPGSDWLGLGSEDPGLELELPSYKPSTPSKTVPKKTKTEDAAAQQKPIQDSTGRRNRGQDSSDGDDFLKMLGITPDDKTPKSPLDGSPRRGRRWRDQSSQEEDPLDLSSSLTDEMKPSPVVHQKAQPTGSSDVPTRSDSPGRDQVLRDQKLETPKTTALPQHGLRDQSLEISRTSAIPEREQETSKPTPLIYQGMRDQIPDVTSKHALPLHKDVPSLHFQSNQHPSQTSISTPSSPYLQQGQLQLTNQMQVHSPQGQPTTQYHTPSNYIPQGSRLITGDKAQLESEMHEIMKRIHEMEGNTQRQQIDGAGYVAQLEAKVRRLEMEIDHLQTTLNSMKTRHHTEMANIDTSNKAHIKTLEESYQLRETRIKEETDLQVSHYKDRIRALEEEKSTMQAAHLRKVQSLESSRNIDLDRIKELHRKGVEEMRQEHEEEMAHLRKLKEQEVSAATSAHGHTKSLQSLMQQVLNSTKDVSDMRTQIETTHKSNISERELAAKARDEYLTHLQERLAKQQAENDEERARLQGLIAKMEVHMREQSRQVDQERWRLTQEDSRIKALQSALEDERRITMEQLAMERADVQRAREELLREQKRITTELQEERRNISMERARLSSAHREILTKEKHKTDTTIQAEAEMEITASKIKEDAAALGVRQAQLKQEEDALRREKRDFSLRLERFEEEKDRIGKLSLEVQRRSEEIGKLCTENTRAREEGEEALARAEMLRRETENERAELENRFILIQEKEKQLAQDRVSIAHERRVLEMDKRNGRCRQCEGNTTDSPLLIADLPDGRISSTPVISALDFDCLSQSPGRTLGTPDILLNSLELKRNLRKWTNEKEKDEEFLEQESQFLNQLRGSRGKTKKRLSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL37</accession>
    <name>A0A6P8IL37_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger and BTB domain-containing protein 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116302505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567676.1">
        <property type="nucleotide sequence ID" value="XM_031711816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IL37"/>
    <dbReference type="GeneID" id="116302505"/>
    <dbReference type="KEGG" id="aten:116302505"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="9">
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            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="340"/>
        </location>
    </feature>
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            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031567676.1"/>
        </source>
    </evidence>
    <sequence length="727" mass="79005" checksum="93D309258F8BAA0D" modified="2020-12-02" version="1">MSFEQVDSGDLASFAAIAESTLANKEGETNPPQEEQEAEKEKSDKSSAKEPENEQTNIEQQQTTQDDTADTTEETSQEYTPEEASQGAEQAAVSTSTAEVTQEVASSESHLPDGQQESTYANLQPIFLAMEMGQTSQHEGQPTTTADISQQTQTLQVSQAITEQGNQLPFSQPSSVLLNSLTTSVAEGSTSVSLQSILQDVVSGIPTTSGTVPAAIITDPSSSTGSYLIVNQNGIPIVRPVLVSNMPENGMSGSETLQVLATGIHGMEGGDSQEPVTVEVSANTDGSSAASGIGDVDPDSSMGMSSEEMSMRVQHHSGSGDEESTPSRLTGGKRKLSDGPRVCEECNKSFKYPSDLKKHLQIHTNVKKFKCDDCGRLFRRLHQLNVHMRIHTGEKPYVCSRCNVAFRHDSTLTMHIRTRHDHLRPFKCDECGNTFGRLSHLRKHVRKVCGNRMNKDRPIAQCRFCEENFPTKGDLRKHVLTCERKEAKVKAKEVTLHVCDQCSKDFASPYNLRRHQLTHTDEKPFQCEVCARQFKEKSSLSKHMKRKHTGVDQGSQTDETGETEYNSVDVIAESAAASGVPIDSDDDQVESMNVTEVASSTVDASTLITDPSEAVRVQGQEDVEMTTIELSLPPGAESHEATALQAAVEALVSASQQQMSMEHSIVVPADPSAGKEIYSNVADVQDNQDVGMVDSTTELVTTEVKATTPEDNQVEYVEANEAPETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM03</accession>
    <name>A0A6P8IM03_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-binding protein IPP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567854.1">
        <property type="nucleotide sequence ID" value="XM_031711994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM03"/>
    <dbReference type="GeneID" id="116302650"/>
    <dbReference type="KEGG" id="aten:116302650"/>
    <dbReference type="InParanoid" id="A0A6P8IM03"/>
    <dbReference type="OrthoDB" id="6357972at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567854.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="62612" checksum="7476E9C7AC86F649" modified="2020-12-02" version="1">MAACADETEKSPSKNPPIRVISLPDAKEKVVEDKKHSSAILLGLHQNYKDEKFCDVTLVFGDKEIKAHKVVLASSSRYFEAMFSSNFIDGSQQKLEIPLFDSKIGTALIDYAYTGKVEITADNVVEILAGANFLQGFDFVEKSCCDYLKFHMSDENALQILQVADQFHQSKLKDHIKKYCFLRFSTFAENKAFLNIPFKLLKEVLSDDHLLVEKNGVVYLGRRQEEYLLEKVLEYIKHNEEVNEKAEQLLKCIHLPLLKNKKLHALKSNDVLQSTECKALIDEALLLKKEKTSKSAQLQEEETDELSQKDWTKPRPCGEYQLWRGRCLANGEQVNDEAVAFSDKEKINVHSDYVTGMDLWIRSWDGRPVIGGMKIYYSNGESCMHGDEKGSTKEEFRLDTDERIIKLDSQSGYMIDCVTFFTNKERKLGPHGGSGGGYRQENPPNYHGYLVCVEGNVVKSQGSLGITKLQFLWRFFRTHDQSHVPDYIEAYYDEFDEDDYDDFYDDYEDYDDYEGYDFEDDYDIEDENFYDYDPTPDDDFWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMP7</accession>
    <name>A0A6P8IMP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Protein gustavus-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC116303011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568306.1">
        <property type="nucleotide sequence ID" value="XM_031712446.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568307.1">
        <property type="nucleotide sequence ID" value="XM_031712447.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568308.1">
        <property type="nucleotide sequence ID" value="XM_031712448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMP7"/>
    <dbReference type="GeneID" id="116303011"/>
    <dbReference type="KEGG" id="aten:116303011"/>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="40"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031568306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031568307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031568308.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33022" checksum="6D6441F5ACED2732" modified="2020-12-02" version="1">MGSRISSVKRSDHNDNRQGLYKSLNFLKEEEDRARDLARPEKLDSVLDRPPIPRERQKDFSWNPSDRSVNVFVKDDDPFTFHRHPVAQSTDCIRGRKGFTRGFHVWEINWSTRQRGTHAVVGVATQKAPLHCTGYHSLIGKTDDGWGWDIVRNKLYHDEKNNPTVKYPAQQDVEHNFTVPDRFRVILDMDEGTLAFETIDGRYLGVAFRGLKGHTVYPVVSAVWGHCEIAMYYIGGLDPEPQPLQDLCRRTIRKSIGKEHLNKANINTLPIPTSMKQYLLYQQGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN69</accession>
    <name>A0A6P8IN69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome non-ATPase regulatory subunit 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568491.1">
        <property type="nucleotide sequence ID" value="XM_031712631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IN69"/>
    <dbReference type="FunCoup" id="A0A6P8IN69">
        <property type="interactions" value="2838"/>
    </dbReference>
    <dbReference type="GeneID" id="116303152"/>
    <dbReference type="KEGG" id="aten:116303152"/>
    <dbReference type="InParanoid" id="A0A6P8IN69"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031568491.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22025" checksum="27772D89032C44E7" modified="2020-12-02" version="1">MADGDVKRVKELIAKKDEIEKQIKEFQEVLESQKGVGMDGNLVDSEGFPRSDIDVYTVRIARNKIICLQNDHKALMKEIEDGLHQIHAMARENEKEEYEKPKLDETADLVPFLKVGSVTDGSPACQAGLQKKDKILKFGSLTHKNFQGMQNVASVVEHSKGNSMPIILLRNEQKLRLSLIPNPWSGRGLLGCHVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INR0</accession>
    <name>A0A6P8INR0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116303303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116303303</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568680.1">
        <property type="nucleotide sequence ID" value="XM_031712820.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568681.1">
        <property type="nucleotide sequence ID" value="XM_031712821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303303"/>
    <dbReference type="KEGG" id="aten:116303303"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653214" evidence="1">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568681.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25498" checksum="A3FF8276439971CD" modified="2020-12-02" version="1">MMNVVIHFYVVLVFVCGSHALPKKEKLNDSNLNTCLFDCGRCVGILGEDKYKRDACMEKCEETNGASRDPDCKNSDFVKVNKLDACFNACAHCTFIHGKSVYIGGACLKECRKTKGKSIDPECKNPEFLMTEAERECLASCEECMDVDYMYGVCTSLCRSTKGASNDPECTSLLMNSGSNQTKEKDDCLSSCEKCNDENYXYKACKYLCNSTNGASNDPNCTKFQNKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ21</accession>
    <name>A0A6P8IQ21_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568540.1">
        <property type="nucleotide sequence ID" value="XM_031712680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303183"/>
    <dbReference type="KEGG" id="aten:116303183"/>
    <dbReference type="InParanoid" id="A0A6P8IQ21"/>
    <dbReference type="OrthoDB" id="5988618at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568540.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39210" checksum="2DF486815ADFC17C" modified="2020-12-02" version="1">MSMPTNIPLPSTLEVSGNLATNWKRFIRAWRNYEIAARLKDPAKPDENKVLRTATFLTCLDSDALDIYEGFKFEDDSDKNDIDQVIAKFEEYCIGQRNETFERYNFNMRTQQEGETVDAYVTALKTLAKTCNFGQLQDDLLRDRIVIGIRDTATRKKLLNMPKLTLKECIDICRTHESTSNQMKTKTQQEVSAVSSRFPKPAKQQNAAKQRRSTHDESSKEIQCMFCGKKHAKDREQCPAWGKKCSSCHKPNHFAAVCKSTSKSRSITRQVSMVDQDSSDDDVLTLEEKESIDVVTYRSHPNQVFVTLVVNNTEVRFQLDSGAXVNVMSDHILSKIMWKCQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ37</accession>
    <name>A0A6P8IQ37_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116303584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569012.1">
        <property type="nucleotide sequence ID" value="XM_031713152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303584"/>
    <dbReference type="KEGG" id="aten:116303584"/>
    <dbReference type="InParanoid" id="A0A6P8IQ37"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000045">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028140516" evidence="2">
        <location>
            <begin position="40"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="344"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="604"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031569012.1"/>
        </source>
    </evidence>
    <sequence length="726" mass="81471" checksum="83865A6D434F1F0E" modified="2020-12-02" version="1">MKIDQKLTTKHSIQINIMILHRVLILLILASCALAGTHAQSHVKRDLTKSVLDISALHSEAVNEISTDRIRQNLEYYAGAPHVAGSEENYQKALEIQKRFVEYGFDKVEIKKYNVLLSIAGLPGSVTLTDETGVELFRSRPFEKILDPAENMTNVVPPYSAFSPSGTVEGKLVYAYFGSSKDFKRLKENGVNVTGKIAIIRYGRGGRGKKVDRAAKEGAIGVILYADPEDFAREGPDKVYPDYNWLPSTAVPRGSIKASKGGGDLLTPFYPAIDGIYREPLSEVIKKEFAAIPTLPVSYGDAARLLSTLTGQLPKFYWRGGLPIIYGVQTDDSDRRRVTLTVNTETLVIIGNHRDAWVYGGTDPSSGTAXMMELARVFGMLLKKGWKPRRTIIFASWDAEESGLIGSTEWLEEHAKILQARGVAYINVDMAIDGNFTFLARSMPSLDWTIIDXAKKYIFVHPSVLGHVYYCIVARLICINIVLFPHVHFHVTRISRMCTDSDYSTFYHMIGVPSMDIRYSFNTAEGAGNPLYHTLHDTYRLVSKLIDPTFKYHQATARVWALVTLNLADSVIIPFNVTHYAKKLAGYRDELKEVADKILMENKISLEYLNKEIQNFKDAAKQFEDIIINTSKTDYLNIRLINNRLTALEKSFIDDGDTPIMSDITIRRHVLLSSPRTSGAYKLPGIRQAIRRARRGEATWDDVKKQISIVVYAIQSAIKLLRLSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQH7</accession>
    <name>A0A6P8IQH7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cdc42 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116303859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569331.1">
        <property type="nucleotide sequence ID" value="XM_031713471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQH7"/>
    <dbReference type="FunCoup" id="A0A6P8IQH7">
        <property type="interactions" value="2407"/>
    </dbReference>
    <dbReference type="GeneID" id="116303859"/>
    <dbReference type="KEGG" id="aten:116303859"/>
    <dbReference type="InParanoid" id="A0A6P8IQH7"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000167">
        <property type="entry name" value="Cell division control protein 42 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031569331.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21246" checksum="DFC3D304CD7687AF" modified="2020-12-02" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQVDLRDDAGTLEKLAKNKQKPLTVEQADKLARELKAVKYVECSALTQKGLKNVFDEAILAALEPPEQPKKRKCNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS47</accession>
    <name>A0A6P8IS47_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CD59 glycoprotein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569991.1">
        <property type="nucleotide sequence ID" value="XM_031714131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS47"/>
    <dbReference type="FunCoup" id="A0A6P8IS47">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="GeneID" id="116304401"/>
    <dbReference type="KEGG" id="aten:116304401"/>
    <dbReference type="InParanoid" id="A0A6P8IS47"/>
    <dbReference type="OrthoDB" id="5963601at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028320271" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569991.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="11653" checksum="2E1DDA6BCDF4C33A" modified="2020-12-02" version="1">MKLLIVTLCVLAYLIPSALSIDCYVCRNSNGNCMSGKTSCSGIACLKAKGGDAVAKTCTNSLGCNVAKSICKNSGDCEAYCCDSDLCNGGVPLKPVKVVTLLAMALAVAKYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISB0</accession>
    <name>A0A6P8ISB0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurexin-1b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116304463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570061.1">
        <property type="nucleotide sequence ID" value="XM_031714201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304463"/>
    <dbReference type="KEGG" id="aten:116304463"/>
    <dbReference type="InParanoid" id="A0A6P8ISB0"/>
    <dbReference type="OrthoDB" id="5975234at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028335387" evidence="4">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="5">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570061.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34186" checksum="C36D4A7622203DBC" modified="2020-12-02" version="1">MAYLLLAALLCVIATGWADIGMKFKESNLPFAEFRPWDVSANGAIDLYFQTKKRNALILYQDDGEGRDWIDVFLVNGIARLRLRLGTCDQAITHLNGNFTDFKWHRLNVERNFSMTTISIDGIRSESLLCEETLESPVKPKPSKSSLYLGGIPLLSKPIGXWSNPNIFHEAQYHGFTGCIARVRYSNGDKKLRKAKYKSSSGTTSNCQGACVGKHSKACKNGGKCLDFLVRMRCDCRGTGFTGMYCQEKLPIVVSFTNATSVTLVNATLMVSAHARGKASAVHVEKPFNTVTVMLCGIYYILYNNHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT03</accession>
    <name>A0A6P8IT03_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">One cut domain family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116304455</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CUT homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570052.1">
        <property type="nucleotide sequence ID" value="XM_031714192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304455"/>
    <dbReference type="KEGG" id="aten:116304455"/>
    <dbReference type="InParanoid" id="A0A6P8IT03"/>
    <dbReference type="OrthoDB" id="10068888at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF47">
        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="13">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="325"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031570052.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43076" checksum="A15E25ACFCAC2470" modified="2020-12-02" version="1">MDMDSRAANNSTPSGNSVNPNALEPLLTLALGASEEVNTTARSKDKSEKNSYMLRSKSSKTKESYMENSSQGILQTTPLNTPITNXSQSSSHQSPSKENEISERVVSANDTDLTQVLLPEHLNLIQVQTVSESTNSNAEGAEAVALPAGLVMIEQAVLEQINGILRNAGTVTNDXIQKIITSAMTPSVQITSSIQDQQTLIQSNTNVSTSEAEEPVLTTDEDEWIDTKATALQLTDELRRYHIPQAVFARKVLNRSQGTLSDLLRKPKPWNEMRLGKEIFRKMKEWLSLPEVKRIPQLRMEAAKDLDTRSKRHISDSEDIRQEGTVPKKVRRQFTEXQKRALFAIFKETKKPTKEMQKALAEELGLDINTVANFFMNARRRYVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITK9</accession>
    <name>A0A6P8ITK9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein ATIC</fullName>
            <ecNumber evidence="6">2.1.2.3</ecNumber>
            <ecNumber evidence="7">3.5.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">AICAR transformylase/inosine monophosphate cyclohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116304669</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:22193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate</text>
            <dbReference type="Rhea" id="RHEA:59144"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57452"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:59145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18447"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="6"/>
    <dbReference type="EC" id="3.5.4.10" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031570287.1">
        <property type="nucleotide sequence ID" value="XM_031714427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITK9"/>
    <dbReference type="FunCoup" id="A0A6P8ITK9">
        <property type="interactions" value="1696"/>
    </dbReference>
    <dbReference type="GeneID" id="116304669"/>
    <dbReference type="KEGG" id="aten:116304669"/>
    <dbReference type="InParanoid" id="A0A6P8ITK9"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="19">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031570287.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="65307" checksum="A243534EC2626109" modified="2020-12-02" version="1">MAAASEGGNLALLSVSNKQGLVEFAKKLHDCGFRLIASGGTANAIRTANIPVRDVSEITNAPEMLGGRVKTLHPAIHGGILARITDSDKADMEKQGHEYIKVVVCNLYPFVKTVAKEGVTVVDAVEQIDIGGVTLLRAAAKNHARVTVVCDPDDYDKIVSEMSASPTQEVLPDTRKSLALKAFNHTASYDLAISDYFRKEFSEGVSHIPLRYGMNPHQKPAQLYTMEPQLPVKVVNGSPGFINLCDAFNSWQLVKELRKSLNLPAAASFKHVSPAGAAVGVMLTPEEAKVAMVDDMIDDLTPLAIAYARARAADRMSSFGDWVALSDTCDLPTAKIISREVSDGIIAPGYNAEALEVLKKKKGGKYCVLQMDPNYEPSPMESRTIFGLHLEQLRNNCTIDENVFKNIKTKQIKYLPADAVRDLIVASIALKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANNWWLRHHPRVLGMTFKKGVKRAEKSNAIDVYVNGTVGKDNDKATWEDMFDSPPELLTESEREKWISKLKGVSLSSDAFFPFRDNIDRAVQSGVHYIASPSGSAADDICVQACDEHGITMVHTDLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITU1</accession>
    <name>A0A6P8ITU1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein C23A1.17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570449.1">
        <property type="nucleotide sequence ID" value="XM_031714589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITU1"/>
    <dbReference type="GeneID" id="116304801"/>
    <dbReference type="KEGG" id="aten:116304801"/>
    <dbReference type="InParanoid" id="A0A6P8ITU1"/>
    <dbReference type="OrthoDB" id="10594767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570449.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="37013" checksum="EA9D9D065001BF32" modified="2020-12-02" version="1">MEINTDDQTPSTSGIPSTTHSEREDGPVGDTEISSSSEDQDTDDSSNEEYCSSDNEGKEEGIFTSYLKKLSSKQDIAEVKEQMTSDALSTSSIINSYLSMNSIIFPQQPRASSHPPVMPSLSSPSSSSPQDILNALSDISSKLERFTANIPTLPEHTNAADTQHVAFQIAHWSSLFISMLQNPIASISLSASSCTSTSSSTSTLMSQPPSTPQPFIPQPFISQPFIPQPSIPQPSIPQPFIPQPSIPQPSIPQPSIPQPSIPQPSIPQPSIPQPSIPHPSTPQPSTPQPSIPRPSIPRPSIPQPSTPHPSTPQPSTPQPSTPQPSTPHPSIPQPSIPHPSTPQPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUG6</accession>
    <name>A0A6P8IUG6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS-type transporter SLC18B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570582.1">
        <property type="nucleotide sequence ID" value="XM_031714722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUG6"/>
    <dbReference type="FunCoup" id="A0A6P8IUG6">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="GeneID" id="116304924"/>
    <dbReference type="KEGG" id="aten:116304924"/>
    <dbReference type="InParanoid" id="A0A6P8IUG6"/>
    <dbReference type="OrthoDB" id="497880at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="75"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031570582.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="53110" checksum="E2377313B06E3C86" modified="2020-12-02" version="1">MAATMRAPSPFKRMMSYEEPRDRSNTKSPVNGVCNGGIHSPVPAKTDEDEEKAKETTTVEPVEVKIWGTARQKLTIVCLAVVYFATCAAFSVLSPFFPKEAANKGASGTVIGLIFGVYSLVSFLVSPLIGVIIPKVGARFTITCGLLLMGGSESLFGFVDSMQPGTIYITFCFILRIVSAIGGSMADVAIFAIVAGAFPKNLGAVMGAMETFSGLGFMAGPPLGGALYTYGGFKVPFLTLGGLVLLTLPLVLCVLPMPDESSSEQRESGSLLAVLKIPGILVLASCILLSGVVLGFLDPTLSPHMAEFGLNASKIGLMFLLIGAVYAISAPFVGWIGDKTGRTRILIVIGVLLGVLGYLGLGPTPLISFLPQKKVWMAAIALMILGLSYSFYLVPVMPDMMATALEHGLPDDIRTHGVLSGIFGSLISIGAFLGPTIGGTMNHYLGFNWSATILAGILAVQGVVLAVFSTCEALMKTSSSTKSTEGNITEDKVVNERTSLLHQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUS3</accession>
    <name>A0A6P8IUS3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116304347</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569930.1">
        <property type="nucleotide sequence ID" value="XM_031714070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304347"/>
    <dbReference type="KEGG" id="aten:116304347"/>
    <dbReference type="InParanoid" id="A0A6P8IUS3"/>
    <dbReference type="OrthoDB" id="5967416at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051145">
        <property type="entry name" value="GAS-SHBG-PROS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040:SF16">
        <property type="entry name" value="FIBRILLIN-2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040">
        <property type="entry name" value="LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027893945" evidence="11">
        <location>
            <begin position="21"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="13">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="279"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="14">
        <location>
            <begin position="488"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="769"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031569930.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="96056" checksum="810E773FE53E5C66" modified="2020-12-02" version="1">MVGGIGFIVFLLLRSFVVEGAYYKVQTQTGGSDGAGTDAKVFIRIFGVGGVKQTSRHELDTNGDDDFEEGNLDTFDVNDNTDVGMPEYIKIYRKSHAFFGNWQLSWIRVTHNGKEFLFPYYGWVAHSRWIKINGKCKPPGLELASNDSCVDVNECATSPCKENSVCKNLVGSFKCECNDGYKPKDQLSCEDINECIGDSHKCNYKTSECVNTPGEYHCKCNSGFKKVSRYECKDXNECVEGSHTCNTTTSKCVNLHGDFYCKCKTGYHQTDSMKLCMKDECAPLARPYKSIIEPARCTQXRANYYGDVCTVRCENGYVLENPNLNSVSCGANGKWNTNTPRCTAVKCPVLLAPTNGRLLPSSCLTEGNKYQGQCTYICNKGYQLSGSPVRECRADKTWTGSKPTCIKVVVKPWIRCPIDIMVNLAPGQKTADXSSLWKEPSYLGEILLVDPPTANAKFRFPAGETKITWTTRNXAGSDSCSILVMVYDKENPKIVTPCPASPVGVLTTTSSATVTWQEPAFSDNVGVTKVTXTRKSGEVFGLGSWNVYYTAYDKAGNTATCEFVVTVKIQGCPELKGPYGGDRKCSSFGQIKYCTITCPSDKQIYKNPSPYSVWTCNSAKWDPTPAVPDCVAAALKDDSSCTGNQVEMAIAFSSGSKTYCADCPRGTYSSNGKCKPCAAGQYQDQQGSATCKDCASGTSSLAGANDVKQCRVVCRPGHYSVDGMDPGCQLCPKNTYQNNPKATSCIPCPAGTTTLSLGMSKLSHCGAKPVITSVTPKTKTIDERQSTSISCYVTGSPTPSITLKFRRNISAGFLGQETREFLRDSNGKVIGIKLTITGATYENSGNYECSAENPFGKVVELSTLTVNQVFGSGADASFDVDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWC2</accession>
    <name>A0A6P8IWC2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571337.1">
        <property type="nucleotide sequence ID" value="XM_031715477.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IWC2">
        <property type="interactions" value="795"/>
    </dbReference>
    <dbReference type="GeneID" id="116305539"/>
    <dbReference type="KEGG" id="aten:116305539"/>
    <dbReference type="InParanoid" id="A0A6P8IWC2"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571337.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19607" checksum="94E8DA9E156B4BB3" modified="2020-12-02" version="1">MQWIRNLLGVFRSGRRLVGTDXDGNQYYEILAGKNRRPRREVITNLKHEQYKDGTIPLEWESWMRGKRXNPPTHDELISMLQKREVLNQRVKKIEAEEERKGEEQDMATRPIGHASAPVYEKXGLKTEPTRTGDTFQPGSWTPGSNTGQPGKGGEEEADIFEPQSWTPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXL7</accession>
    <name>A0A6P8IXL7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116306260</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_031572146.1">
        <property type="nucleotide sequence ID" value="XM_031716286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXL7"/>
    <dbReference type="FunCoup" id="A0A6P8IXL7">
        <property type="interactions" value="1269"/>
    </dbReference>
    <dbReference type="GeneID" id="116306260"/>
    <dbReference type="KEGG" id="aten:116306260"/>
    <dbReference type="InParanoid" id="A0A6P8IXL7"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000008">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031572146.1"/>
        </source>
    </evidence>
    <sequence length="731" mass="83247" checksum="861EA8EF4ABBA7D5" modified="2020-12-02" version="1">MATVSKENLDLSQYTISTNTTINFLDCQNAFEGLTDEEKLYAHYLLKASWEGSLICLFQTSPEAPRIFQLFQKVFSFEEVSEIKERALKAENGLTVEEFECFLMYVASFYGNIGNYKSFGDTKFIPALSKEKFQAIIYASKAYQDDPKAVENPWQDCKDPMYSLGVKLRQLGFGDQALSTYYSSNCDKSDAEFVQGFLKEKGIDAYNTRLFKEVDADQRITYNLRIASVCTTAEPLNGVEDKMSSLIASHEYKRCTIKITRGDYSGLLKRVVENLEKAVTYASNEREKSMLKSYIISFNTGSIEDHKQGSRFWIRDKGPIVETYIGFIETYRDPFGVRAEYEGFVSIVNKAMSEKFGQLVAGAEKLLPCLPWPSSYEKDTFLRPDFTSLDVLGFGSSGIPAGINIPNYDDIRQEEGFKNVSLGNVLSAHSADQKITFLDEQDAEIYAKLKAPSFEVQVGLHELLGHGSGKLFMQKSDGTFNFDIESVKHTETGEKIQSWYTEGENWYTKFADISSSYEECRAECVGIYLCLNQQVLSIFGHEGEMANDIIYINWLNMVRAGLLGLEFYTPENNKWRQAHMQARYVILRVLLEAGQQLVKLEKINGSDGQPDLILTLDRSKIECVGKLAIGDFLRKLQVYKSTADYEGGKALYDHYSKVEEEFLEYRKIVLARKTPRRMFVQANTRCQDNKVSMSTFSSNAEGMIKSFISRFPRDDHVLEGLWRADLPHHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYA6</accession>
    <name>A0A6P8IYA6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116306528</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572471.1">
        <property type="nucleotide sequence ID" value="XM_031716611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306528"/>
    <dbReference type="KEGG" id="aten:116306528"/>
    <dbReference type="InParanoid" id="A0A6P8IYA6"/>
    <dbReference type="OrthoDB" id="5964882at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027605750" evidence="2">
        <location>
            <begin position="22"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572471.1"/>
        </source>
    </evidence>
    <sequence length="855" mass="95036" checksum="B1FCA045C83F922B" modified="2020-12-02" version="1">MSAFLANALVFSIVCVNLARCSHFRGATLSWKSVNASSTTDKRVIISLRIAWRRSNTYCDQSTINSGRLIGPSGSRLQCRSGCSGYVGSMDFKCTDFSVQEDWSAGERNYTYRFPDIHSPLYQASFTGSDWISLVKGGGNWEVRMYVNLTKRKDTGLINTSPTAALSSIIRLQYGCNHTIVIPVSDADKDDIRCRWAESSKYECAGVCRTFPGAVLDERKCQMEYLATGRIGWYAVAIMVEDFTDRLSSNALSGIPIQFLVQVFTSSASCSSKPEFSGETRVDGSCIGVPHGSTLNERIIAKSQGTGNRIIEITTISPSGLTKSSLAQYSANEWYVNVTWTPSQSQVDPVIFCYTAIDANGLSSDQSCVTLLAGVAPPYXVNGSHFPTGLIYPNNQRWTVKFDKEFVRPKRSRYIRIFRSDGTEVYTVDVSISHDVIYPEDSLGRALEFRPSLRLVEESTYYVLLDRGIVRGTTYCDLESPPMRDPHFWRFTINKLLEPPVLEASSSGGIEDTPIPVFLSARMSGINRTDDVTLSITIYGVPDSFVFSRGMRSKDQVTLLKQQFGDLFVTPAKDFSGNFTVDIVAQAARGLEKTQTNYSFTINVKAKADVPVLITGDACANLTGLIPLNIKALLNDNDGSEKLTIALSGLPNEYQLSRQGRLVNGTHYLETDSLTGLVARYDGVFEPFVLKVVATSVEKSNGDRASVMTIINVTSCILQFTCEKNCSDHGFCVAPDQCRCEEGYTRPDCSQDKRSNSDEVHHIIPIAWYILRDQIRWSNAAEWATFRNSWDTFPNAVGAIDCTIHRIWRPSVRQATYYRADKKTHFLATIVIVNTDGLPVYVRAEYVLSMRNGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ92</accession>
    <name>A0A6P8IZ92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116305362</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031571115.1">
        <property type="nucleotide sequence ID" value="XM_031715255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305362"/>
    <dbReference type="KEGG" id="aten:116305362"/>
    <dbReference type="InParanoid" id="A0A6P8IZ92"/>
    <dbReference type="OrthoDB" id="5855429at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000024">
        <property type="entry name" value="Transmembrane agrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052229">
        <property type="entry name" value="Collagen-VI/PIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588:SF3">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08685">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027806664" evidence="4">
        <location>
            <begin position="23"/>
            <end position="5933"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="GON" evidence="6">
        <location>
            <begin position="225"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="455"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="514"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="708"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="796"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="849"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="1293"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="1662"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="1849"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="2036"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="2219"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="2405"/>
            <end position="2582"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="2591"/>
            <end position="2776"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="2777"/>
            <end position="2951"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="2962"/>
            <end position="3136"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="3146"/>
            <end position="3322"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="3334"/>
            <end position="3505"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="3521"/>
            <end position="3696"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="3707"/>
            <end position="3883"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="3895"/>
            <end position="4069"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="4077"/>
            <end position="4252"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="4263"/>
            <end position="4438"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="4449"/>
            <end position="4624"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="4637"/>
            <end position="4812"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="4823"/>
            <end position="5000"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="5011"/>
            <end position="5186"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="5197"/>
            <end position="5372"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="5385"/>
            <end position="5559"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="5571"/>
            <end position="5746"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="5757"/>
            <end position="5931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4411"/>
            <end position="4431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="5933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571115.1"/>
        </source>
    </evidence>
    <sequence length="5933" mass="650994" checksum="BA20CBFF2B621A85" modified="2020-12-02" version="1">[encoded data, 5933 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZC5</accession>
    <name>A0A6P8IZC5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Protocadherin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116305383</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571145.1">
        <property type="nucleotide sequence ID" value="XM_031715285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305383"/>
    <dbReference type="KEGG" id="aten:116305383"/>
    <dbReference type="InParanoid" id="A0A6P8IZC5"/>
    <dbReference type="OrthoDB" id="5954590at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000094">
        <property type="entry name" value="protocadherin gamma-C4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571345.1">
        <property type="nucleotide sequence ID" value="XM_031715485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305545"/>
    <dbReference type="KEGG" id="aten:116305545"/>
    <dbReference type="InParanoid" id="A0A6P8J052"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571345.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24796" checksum="9A997818A17312F7" modified="2020-12-02" version="1">MENIGEEVLVHIFSYFDVKTLCIASEVCHQWYGTANISGLWKSLCGIRCKKENRPCHLGRADSWKERFIQLYSGRITSRKRVKETLMPSFEELRKALIPANGRFMEFRVKKRQGIREFIQSKGLDYVVGNAFYQHTKTETISFKKKIVLKSKENGAIYEGGQAARDMVGLRKGSQDWNIHPQTLNKQATKDFVVFIQSTXVNRALVPKTSVLYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0B6</accession>
    <name>A0A6P8J0B6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116306893</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572884.1">
        <property type="nucleotide sequence ID" value="XM_031717024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0B6"/>
    <dbReference type="GeneID" id="116306893"/>
    <dbReference type="KEGG" id="aten:116306893"/>
    <dbReference type="InParanoid" id="A0A6P8J0B6"/>
    <dbReference type="OrthoDB" id="6019201at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027039">
        <property type="entry name" value="Crtac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16026">
        <property type="entry name" value="CARTILAGE ACIDIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16026:SF0">
        <property type="entry name" value="CARTILAGE ACIDIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027655744" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="ASPIC/UnbV" evidence="4">
        <location>
            <begin position="574"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572884.1"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114351" checksum="05E36DC383B9A1C2" modified="2020-12-02" version="1">MSSLKLFIFIFEICLWLPCTSTLSPRIFAASDYFIVNDQEVRQQTADDRGVLRNRRTTLDKLQLVDNDVVLDPPRAEKTCVLTSILTASQPKDRMPSHNHFQDVHKEAGFHHIHRDYMAVRPHCVFDFIIPHHNSSKETRLRGEFCIPEHLTGGAAVGDYDNDGLQDIYFTLFHKTSVLYRNNGDGTFTDVTKDVGLGPSRCASGAGWIDVDEDGDLDLYVTTVGDSRHYLYINYGGFFVEEAEKRNCSLVFPNKRKLAGMTPNFGDFDRDGFLDIYVTEWILHTVGKPSASRLLRNKGFVKAGYFEDITDQVGLNMDGYRGGSSLNRGTHTFGASFTDFDEDGWPELLVTADYGDSKMFWNKNGKSFVECTEKCGLRGEQDAMGHAIGDWDNDSHLDWFSTAIFHNQTDCSITGCVFGSGGNRLYRNHGNRRFDDATDKAGVRNGGWGWGAAFIDFNNDGYLDVVMTNGVDFPSTTTDDHFQKQSMILWQNLGPGYNGSTKEVSNAVGLNATGQGRGLLKFDFDDDGDEDVVVCNNLGPPQLYDNKGGNKRNWLKVRVVHNCLTFSDKLCDSYGARVQVLTSSNHIQTKEVGSDTHFLGQSEITTHFGLGSESGNVDVKVTWPGGLFEVTVTDVQPNRRIRVMKPSLQLGGKQSTSFKNLTVCSTLRIIAIEKQPSHATVVINPDGRSVSFKIDEGVNMRSLNMETFVYRVALVQGDNTTLLNTTTTAFVVFHYNDSDGGSNSGECVNGRHAGSKPTPTNKRRFDGISNNQKNVFWGANMEDLTRDIPAAYEDKLASLSGTCTIQQRKLGTCTFPDELNGIGSNRPSPRNISNVLFYQVKSKISSRRLSDMHAHFGQFLAHDTDFSSPLPRFEFDGQLNDVWLPISVPKGDVHFDQRDKGTEYLSFVRSTFNRCTGRNHGTPRQQINKITSYIDGSVVYGDSEGRNAHLRTKQNGKMKLTRNGIIPSNSMGIANDNVVGRDASRLLVAGDTRANVQPGLIALHSLFVREHNRLCDEYLKTHHKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0C0</accession>
    <name>A0A6P8J0C0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-fucose kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116306898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572889.1">
        <property type="nucleotide sequence ID" value="XM_031717029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0C0"/>
    <dbReference type="FunCoup" id="A0A6P8J0C0">
        <property type="interactions" value="926"/>
    </dbReference>
    <dbReference type="GeneID" id="116306898"/>
    <dbReference type="KEGG" id="aten:116306898"/>
    <dbReference type="InParanoid" id="A0A6P8J0C0"/>
    <dbReference type="OrthoDB" id="271303at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="458"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="8">
        <location>
            <begin position="638"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031572889.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="81414" checksum="7AFABC8FB2EF1406" modified="2020-12-02" version="1">MNSVIKGPITVGENSVISHCYLQGNITVGNGCVVSGIGPDDYKVNEALQIPGLLCLLGYNISFPHVNNKYNKVFVVFGINDNPENLVSNEASGTFCNKTWKTFFERTGIKSTDLWMHGLPEENRNLFNARLFPVVHHIGNDSDDPPLYDCLWLAGINVKTSNETMIQRWFSSLRVSLKEILSNIDLGVEFYARRQLFFDIGRRHVEAALMGGTNECFLPFLKTCAVEGFHKEILETMDNVASSSGSSMGVAARTLACIADVLGAMAGEKAGLRSGPAQNDAWKHAFQLLEDKKIEDGVKALALERSKWMDRPDLLIRAARHYEGAEQILRRHAVMTAKQFMKFEKTDIPPMDRWVIAEAPVRIDFSGGWTDTPPIAYEHGGVVTNVAIKLDGKKPLQVKAKRIHKFQIILVILAGKHSVRVVCEKLEDLADYSQPHAPGALIKACFCAANIVVLDSPKSLADQLKERYGGGFEVHSSADVPYGSGLGTSSILAGVVMGAVLRASGLTADVTSLIHAVMVVEQMLTCGGGWQDNVGGLAPGFKIASSKASLPIEVEYEVLSVSDSMVDQLNKCLVFVYTGKTRLAKNLLQVKEDLEPNDIKEERLVIHSFNQNVVRNWYGRQPNIVKVVDDLADNAKTLAKALVDGDLTLFGQCVSNYREHKKLIAPGTEPEDIRRMMEDIQPYAYGQCLAGAGGGGFLCVIAKSPEMRQKIEETLGNTKFSDEVAFHEVSIDNEGLTIRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0C4</accession>
    <name>A0A6P8J0C4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein nst1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572917.1">
        <property type="nucleotide sequence ID" value="XM_031717057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0C4"/>
    <dbReference type="GeneID" id="116306919"/>
    <dbReference type="KEGG" id="aten:116306919"/>
    <dbReference type="InParanoid" id="A0A6P8J0C4"/>
    <dbReference type="OrthoDB" id="5980012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572917.1"/>
        </source>
    </evidence>
    <sequence length="853" mass="91764" checksum="3C951BC02E90C9BF" modified="2020-12-02" version="1">MNSKPNDDSGVLEVQQEITTTEETQGSVLESRPERIRRLNRERQRRRRMKLKMSRQDEPTMASESSSNVNMNLDNLEAVFENANTGHDRDDIEVKTDSEHAETGLGKTRATRRRISRRKRTPVNVSSPGETANQGVSESANNAITEVCHGGQLTTPSNELSEATDQLAVLVVASEIEVFGENPSNSGVLNGAGEEESHENAYADTGEAKRSTRSRKREDGDEARIPRRKRSSTNSEEEITVRREKQRELKRKQKERMTPDQVEALRARYREWRRRRKEVMTSEQLEIIRRGNRERQRRRRERLGVRKRAASTSSQSRGASEAVLQGIRNMQTQGRSASEASSAGDSSKGSVSELMTASGLLDDKTAPSSVMGSNLPSNLPTMVTHLQASIANNPNPQVPTTNIVSVPASYAQLQTTTIPVIGPQGTLLPGMAAGTFFPGVTMPGMQVAGLQGAIFPGMPVPGSAAQAGIIQSSGNQTITTIPMSGVPGIQTAQGGFLSGIPVTSTQGNVQGVQQTYPNLPGFPREGQVLHNFQTLLPITPVQGQTPGMTFITQVPFTSAGQFQGLPDPKYTVANQASAQVQGLPPVTQLVQVPIPVDSTPAEDPKPAATEQPGQTKGKPKTRGRKRNTSAAEMLASLSNYVPSTSTPMASMLSALASSARDRQSSSTPQGTEELTGENAQNKTIVIEASQGQQNPSQAAYGMYVTQPRGIDPYMLRTVVSTVQTHTTIDVNSNNYTLAATSNGPSNIPHMNTFLTAIGGPQRSTAVPLTAAQVTRVPGQHVVDADMISVAVATDMIQKATKGTNTGKVENPDSLISVGTMTDSLYRSSVATNTELANNSGVPIEIKVETDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0R5</accession>
    <name>A0A6P8J0R5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Basement membrane proteoglycan-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307058</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573059.1">
        <property type="nucleotide sequence ID" value="XM_031717199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0R5"/>
    <dbReference type="GeneID" id="116307058"/>
    <dbReference type="KEGG" id="aten:116307058"/>
    <dbReference type="InParanoid" id="A0A6P8J0R5"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen-like_C"/>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
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    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="187"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="276"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="365"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="9">
        <location>
            <begin position="448"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573059.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="77313" checksum="508D77F3DF77E8F0" modified="2020-12-02" version="1">MKDKTLHPRSAMSTVTTVCSICFVLLSCGEFMRIELVMRQQNTRINQLEKKMTRAFNDKIFVNAEERGDHIYFARMEDHRKSNRRFVRSVPNNKEANETTYKTIDAKLTKMIEGKINKAISAKNFIAIQGRRGRRGPRGPPGPMGKPGRIGKQGMPGLKGDPGQNGAPGPRGMQGPKGDRGPSLEPPSVVISPPHLIVNESNSAIFHCSASGYPRPEIVWTKVNRLLAGNRSVVDSTGKIQIMNVLPNDTGIYQCQASSILGKVRDTARLVVNFSPRILLANGPVRVKIGNNATFPKCHVTGYPTPKVTWSKSVGSLPRSRATMNNDQLSLLNSRMDDSGAYLCTAENVLGNAVGESILIVVPLPVFTIKPAPSYYNLAGTQLAFNCSAIGNPKPVISWRKENGVLPVGRHEIKQDGSLVIKNLVKSDSGVYICTATSADVADVQARTLLRDPYIDCSGVLRSSNTNSSGVYEIKLNSQRVFRVYCDLTTDGGGWTLIARFSNNDTKNWMRDDGLWWYDLMTGKGNTTNTSENKDMISPAFWSVRGREIKITRSDDPLHTALLRTTTNCLGSRTFRAKISSYGIFKRKAVWSNDKCLGRCDVVYGGYYQTTSGFNQAQCSSNLQSSNKIGFWCNWRQGDGSVMMIGGGGNSCGRADHGIGITECNKGSFEEWSDKGEFDFGNDATVSKTTSRSATYSLNLWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1Y9</accession>
    <name>A0A6P8J1Y9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor subfamily 2 group C member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116307429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573544.1">
        <property type="nucleotide sequence ID" value="XM_031717684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1Y9"/>
    <dbReference type="FunCoup" id="A0A6P8J1Y9">
        <property type="interactions" value="3208"/>
    </dbReference>
    <dbReference type="GeneID" id="116307429"/>
    <dbReference type="KEGG" id="aten:116307429"/>
    <dbReference type="InParanoid" id="A0A6P8J1Y9"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="42"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="169"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031573544.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="46432" checksum="F3A2F100AB9533E3" modified="2020-12-02" version="1">MNDTRRSNIQPIAHKSGDWSSTNVAVQSLTTTNKSNSTTISWGDCRVCGDRATGRHYGVVACEGCKGFFKRSIRKKLVYGCRAEGDCVVDKIHRNRCQRCRLEKCFKVGMNQDAVQCERKPLKISLSPTNDLRRPSTEEQDECGTTLSETRLNVASFGRSTCAPIQISSASHSTTNVPGDIIGTQHSEFKLHIPSLAIPKLSMDYIYEFATRLLFQSVDWARSISAFRSLEKSDQVVLLQRSWSEIFLLGVAQCIACFPFSPLLAFAAQSLKQKEEHQKPRVFSSNHSPFSNFEKLIIVKDFVFSFDKLELNGMEYAYIKAIVLFNSDPQATVTDLKLIDSIQEKTHCSFKAYIEREYPEQPGRFAKVLLRLPAIRSIEQSLVEELFFSQLIGNVKISDIMEYIVSQSPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3L0</accession>
    <name>A0A6P8J3L0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116306283</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572170.1">
        <property type="nucleotide sequence ID" value="XM_031716310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3L0"/>
    <dbReference type="KEGG" id="aten:116306283"/>
    <dbReference type="InParanoid" id="A0A6P8J3L0"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="22">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031572170.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="54993" checksum="537E660ED78BBBAC" modified="2020-12-02" version="1">MADKENDPLGSTEARQPLTKDEEANGDVPEVKIEDKVQLKKEVTLLNGVGLVVGVMIGSGIFISPKGVLIRTESVGMSLVVWAGCGLLALCGSLCYCEMGTMIPKSGAEYSYLKETFGPLPGFLYSWTLALIIRPSSIAIVALTFARYVTQPFFPDCEISPLAVRKVLAAACIAVTIFINCASVKVATRITDVFTLGKLIAIAILVVIGIVTLAEGNVQYLKDPFDDSESNPAAIGLAFYSGLWAYDGWNALNFVTEEMRNPARDLPRALMIGIPLVTICYLLTNIAYIAVVGGEGILTSGAVAMTVGAMKLGPVAWLIPIFVACSTFGCVNGLAFSGARLVYVAARSGHMPKALAMIHRKRQTPMPSIIFMNVIALIMLIPDSAQFSTLVNYFSFAAWLSYFAVFIALLYLRWKRPDLHRPYKVWIVVPIFTALVALYLLITPFAMEPIESSLALIFIALGIPVYFIFCKWDLVGKCGGCDNFNLLIQKLFDVAVEDEKDEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3T1</accession>
    <name>A0A6P8J3T1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574259.1">
        <property type="nucleotide sequence ID" value="XM_031718399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3T1"/>
    <dbReference type="FunCoup" id="A0A6P8J3T1">
        <property type="interactions" value="3148"/>
    </dbReference>
    <dbReference type="GeneID" id="116308046"/>
    <dbReference type="KEGG" id="aten:116308046"/>
    <dbReference type="InParanoid" id="A0A6P8J3T1"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13284">
        <property type="entry name" value="PH_OSBP_ORP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000074">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000003">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574259.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="88868" checksum="2EF802A16025651F" modified="2020-12-02" version="1">MAEVDGFTVIDLPKKGKNVKKSPEKKMPDGRVCPDHFRGWLLKWTNYIKGYQRRWFVLSNGLLSYYRSQAEMAHTCRGTINLAGAFIDTLDACSFVISNGGTQAFHLRASSEVERQRWVTALELAKAKAIKMLESDEEEDEPFEDIKPLSAKLEDLHTCNDLVGKHGSALQRSIGELQEIEDNQTLINKLKAVNEKATLFRITSNAMISACAEFLDLAQAQEKKWHKSLEYERHQRINLEETVEVLARQHNFLERACQRRGGGPPGEPPDEVVANDSDEDENEFFDAISEHSVSDLSVRGSQESIQSSTSSESYGKEVEAKPLLPKEMENKVEGKKNEKLKENTVTTLATVFPQSGTFAAISSYPSFDKESVKKRRTSIQPRPDISINLWSILKNCIGKELTKIPMPVNFNEPLSMLQRLTEDMEYSEVLDRAAACHSSLEQMCYVAAFTVSSYSTTSHRTGKPFNPLLGETFECDRSLEKGWRSLAEQVSHHPPASALHVEHKDWIFWQEFTATSKFRGKYLQIIPQGVAHLKFTKSGNHYTWRKVTTTVHNIIVGRLWVDQSGEMDIVNHTTNENCHLRYDAYNYFGRDTPRKVTGVVTDASKVVRYVISGTWDHKIDCAKVVYHKPSGGKGAVPPSSQKGQPQTLPPSTIWTRVLPPPEHDQMYFMTEFAITLNEEEDGVAPTDSRNRPDQRLMENGKWEEANQEKLRIEDKQRAWRRRREQESADALNEGIVLESYKPVWFEQIVDELTETPMHVYKGGYWEAKEKEDFSCSPDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4B0</accession>
    <name>A0A6P8J4B0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116308266 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574512.1">
        <property type="nucleotide sequence ID" value="XM_031718652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308266"/>
    <dbReference type="KEGG" id="aten:116308266"/>
    <dbReference type="InParanoid" id="A0A6P8J4B0"/>
    <dbReference type="OrthoDB" id="5969782at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00934">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="661"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="719"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="900"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031574512.1"/>
        </source>
    </evidence>
    <sequence length="1191" mass="130712" checksum="DDCCE06BC4FC7611" modified="2020-12-02" version="1">MSQFRVQKVTKVKGPTELSTGKSSESSSKKVRANPSPTDRPQAQPRLKKSSASTKSAEDKSTPSGSDKTQRSKPTTPKRTATKTCSSQQSKRNGLPQTASKQNRKTGAESQKSTSASSKPSVPKKPPHQETTVKKSPKIEKENSYDASGSDSDDLHLFGKLSPKDDIGYETGSFDEIDGSNSETTSPAAGEENKTILGQNLNGENTAGYSYAEVEFRPLVVTDEGGLSTPVPTTHQEKLQNTQTHKDENNPSVEHLSYAYVGEEFRPLIITDSGGIAGPLEKKKSSEPTNNCLLVDQRRAPMRYEEVEVLGGKFDRANINTTHLISGMPGNNDTAVENEDDTYEAVNQQNISRTEQISNATQKDFTAADDGQGVGDIYAVVQKDKTKKDNKISSGVLYKNQEPEVPPEIPSRSNITKSDLCESISGELQDMINSYDDNSPVGKISRSSSRDGYSSSDSGKVTARPPPLPKPYSGPGVSLAFENNEAASSDEDCVGSPLYAAIQKKPKKKTPPKKPEPKQPEEEPPPLPSRTLLDEKDDTLGRDVSLSQLEKESQEKSKKSGFGIFKKKHLRKMSDGNVINTSREALGYPAPGSSKKGHKRSKSQDDMTIXMNNLLGDPGKIRSGSGQLIEPYLAVDITNPPDTPKELHKPKYYMEDECEDGDLPDGWKEVESENGTKYYWHVSSGTTQWERPQVSQRPKKKTSGEQPLPQAVERQKVLSFPIHSMGWIELEENQVAPHNMSDTIAECISTLAKNRKDLWQTSETWGEGKDIRLLLEGDTLKLVEPRNKITLLVQPVSKMRVWGVGKEDHRDFAYVARDPSTSKHKCHMFRCHGNISGRAITTALHEMCNKILEEKKRAQEISKMNSQAKPWSDIINTPPPLSAKDGASFNEKPLREPRKDFTATYLGSTDVPKPTGMEMLNKAISRVASKGGAKRTVLIQVTVSCIRITDCTSQEEISEDRVRFLSFMGVGRDERLCGYIMVNDQDNFVCRVFQCSPNAGMLAKALEEACQLRYQKALDAHPEMASKITSSQEQEPDKSKDKANFMSSVQGLLGKLSTTKKNGGKKEEVASAPPLPKPSHTFMVKYYGALPVAVGTGIETVEEAAKHLTGGTLLICQLDVAINGVTLYDSQRSALSRRHMDADTISFCGLTSDSGHFGLIQCQGGGKYVCHVFSEYKTKAGPIVAAIHETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4H6</accession>
    <name>A0A6P8J4H6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Homeobox protein six1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116306485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572415.1">
        <property type="nucleotide sequence ID" value="XM_031716555.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572416.1">
        <property type="nucleotide sequence ID" value="XM_031716556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4H6"/>
    <dbReference type="GeneID" id="116306485"/>
    <dbReference type="KEGG" id="aten:116306485"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000063">
        <property type="entry name" value="SIX homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031572415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031572416.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30696" checksum="4E344D40FFD0956C" modified="2020-12-02" version="1">MLPSFSFTPEQVACVCEVLQQSGDIERLGRFLWSLPECETIQKNESVLKAKAIVSFHNGNFQELYRLLESSNFSPASHPKLQSLWLKAHYLEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRNILREWYSHNPYPSPREKRELAENTGLTTTQVSNWFKNRRQRDRAAEAKIRELTNDARNGKLLSNDKQGNMDAKKCVTTDFSQCLSQSIPVNVKLEVDEATLMGVAHHADSVNDFSQGLQDSNMLTTLTNSLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5S0</accession>
    <name>A0A6P8J5S0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DBH-like monooxygenase protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116309060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575456.1">
        <property type="nucleotide sequence ID" value="XM_031719596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5S0"/>
    <dbReference type="FunCoup" id="A0A6P8J5S0">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="GeneID" id="116309060"/>
    <dbReference type="KEGG" id="aten:116309060"/>
    <dbReference type="InParanoid" id="A0A6P8J5S0"/>
    <dbReference type="OrthoDB" id="10003276at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.310:FF:000004">
        <property type="entry name" value="DBH-like monooxygenase protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1210:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1, like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DOMON" evidence="12">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031575456.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="66292" checksum="B11A01BE84CE5DAE" modified="2020-12-02" version="1">SAYLDESKTFKIYWKINNEKKSIQFAARVKTLGWVGFGISSGNGNMIGSDVIIGWVKENTGYLKDRYADAKALPPIDAKQDYTLVAAREDNGETIIEFSRLWNTCDEKDNKIEEGTVRVVYAYHTNDPTSEENIPQHSVRGAASLVLLNVFTSKPSIPQNTPHFDLRQNDTVVPDSDTTYFCKSYEFPQYSTKKHVIKIEPVISSGNDRVVHHMLVYECNRDFPRSNLSVNGPCYASNMPPAVQECTGSSVIASWGIGGGPFYFPNHTGFAIGAGVGPRYVILEIHYDNPQRKSGIKDSSGLRFYYTDSLRQYDAGILWAGWNVEFAMMIPPYQQQWMTTGYCSGMCTKIVSYRKEYQKHLQIYLAKLDVPTIYLIGLGTALKTRHVRDGKELPEIARDDYYDFNYQEFHISRKETHIAPGDDIIVDCQYQSKDKTRPVTGGLKSSEEMCMSFLYYYPKVELNKCLSADYGMYPFFRKHFNVNGSTVGYPPAQWTQNLTNELKESYDKNPYIRLKCVYQAEVKSPVYNNYTLKPIVNVPYTKEGDNCPTAIPSTTKPVGEPSAAGLQTVEMFGATLAAFVALVLNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6M0</accession>
    <name>A0A6P8J6M0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein LEG1 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116309026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LEG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575414.1">
        <property type="nucleotide sequence ID" value="XM_031719554.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J6M0">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="116309026"/>
    <dbReference type="KEGG" id="aten:116309026"/>
    <dbReference type="InParanoid" id="A0A6P8J6M0"/>
    <dbReference type="OrthoDB" id="17046at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008499">
        <property type="entry name" value="Leg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18820">
        <property type="entry name" value="LEG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18820:SF1">
        <property type="entry name" value="PROTEIN LEG1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05612">
        <property type="entry name" value="Leg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031575414.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50915" checksum="F00FB8BC7666C136" modified="2020-12-02" version="1">MHLETKSRLSKKISLGVRFLSRICKLPQPLARIISASWRPKHAVVLKMPILKSFLDHPSEVQQVFLLEKVGSTHRMMKGSINHGVLAFGVILICLFQEAFSAISKETSPYPPGWENAASSLEDFPVREMGGKNVTIVDPWLYIDRLGIFKIMVISTERYFSAWGFNYSGNLLWGLPLQFGWQMTTGRLSVTKPHSHDLSIITKFSPSSWWADMNYFLSIIPFLGALNAGIVISVKNPLNVLKPSNVSMELRDKFCTSVXECVSKHSKLMNSWTKFFQHLHENTDKNKKNDKDATVGLLWTAHTDSIRTANPLFLDQRALLSTPEMHFGRGWALLVDFIAATYFQTNLNNTHEQQAMALPPRILHNTDHPPDIPDFNKDQNNALVIINTIYYVEELTNGGFLYLWRKAMCSPQGRADGREMLESLLRHPLVVAKDLVKLVLDFIKDHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6P5</accession>
    <name>A0A6P8J6P5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box/LRR-repeat protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">F-box and leucine-rich repeat protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573553.1">
        <property type="nucleotide sequence ID" value="XM_031717693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6P5"/>
    <dbReference type="FunCoup" id="A0A6P8J6P5">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="GeneID" id="116307438"/>
    <dbReference type="KEGG" id="aten:116307438"/>
    <dbReference type="InParanoid" id="A0A6P8J6P5"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000260">
        <property type="entry name" value="F-box/LRR-repeat protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00070268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00077971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573553.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43717" checksum="09E93E42FE137767" modified="2020-12-02" version="1">MEHKSWADLPEHVIVSIFSYTSIPTRSKLALVCKSWLDAFKSPFLWHSFTFQFLTPEDFKYEPFLHQHGQYLRSVYIRCNQEDKVNRENACKLIRGLYELEKQRLERLKINFTGENPLFYAGQEFVECLRGIFGSPPTKVETKNVQVLTRLKSVDLRGLPVALNDELLLCLAEHNAETLEYLDIQNASLVCKVTASCILKLVRRCRKLKSLATHYGNITEEILLSFIEEGRSPLSNLSVLCRREEKYGRDISSETWSTVRAKLPNLRVTLYFDLSCPMFKVNAILKPEIPVSYLRLLVQARLVQQVYFATQYYSKTLEKIALSTTNSPELENALLHLSSACNKLNEIHVFQCYVSSETKVKILKMLPNLKKYTLKTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ01</accession>
    <name>A0A6P8GZ01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DnaJ homolog subfamily C member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116286379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031548748.1">
        <property type="nucleotide sequence ID" value="XM_031692888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZ01"/>
    <dbReference type="FunCoup" id="A0A6P8GZ01">
        <property type="interactions" value="1933"/>
    </dbReference>
    <dbReference type="GeneID" id="116286379"/>
    <dbReference type="KEGG" id="aten:116286379"/>
    <dbReference type="InParanoid" id="A0A6P8GZ01"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="386"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031548748.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55916" checksum="EED1F4BB6D24DB13" modified="2020-12-02" version="1">MSPIYRVLSSILFITIEIDFKAAYGKLSGVEVQRHLDEGKRLLSSGQLNDALIHYHAAVDGDPENFLPHFQRATVFMALGRSKSALPDLDRVLELKPEFYQARLQRGNVLLKQGCLDEAHIDYEAVLRYSPDNPESLQQLSVIEPVKRNVADAKHAIERGDCQHAIELLGTAIEVAPWDPELRLMRAECYERLGDLVKAISDIKPTTKLINDNTQGYLRMSQLHYEMGELEDALREIRECLKLDQDHKECHPFYKKMKKLNKLLTGAQDLINKEEYAAATEKLKKALKVEAHIRPIVGKMRRQLCHCHVKLHAPKEAIKECNLALQLNENDVDALCDRAEAHILEDNFSEAVKDYQKAKNINDQLHKVQEGLERAQRLLKQSKKRDYYKILGIKRNASKKEITKAYRKLAVKWHPDQFKEPQEKKKAEKHFIDIAAAKEVLTDPEKRQKYDNGEDPLDPDQQGGGGWPFQHGGFPFGDGYQFKFHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZY9</accession>
    <name>A0A6P8GZY9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosome-associated protein CEP250-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548686.1">
        <property type="nucleotide sequence ID" value="XM_031692826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZY9"/>
    <dbReference type="GeneID" id="116286350"/>
    <dbReference type="KEGG" id="aten:116286350"/>
    <dbReference type="InParanoid" id="A0A6P8GZY9"/>
    <dbReference type="OrthoDB" id="5964730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031548686.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38747" checksum="D46FCAE7D86555E5" modified="2020-12-02" version="1">MTNKQQLDLGNVARNMSSDEQAISLIARLVTQPAVNLESSEITRHTGEISELKEQLEQKDAEIIELRKNVKQLEEDNHNLLIKLEAKDEEVKILKKRIQLLEDEKKILKEELAAVHFKLKSIEEEMKNIQQSRQDDEEKSSKLDEEMKMIHYTLKEIKKDLAATKSENEVLKKQIRHQTRYVPGALPLMSVQVSEEANASKNLGEMCLQIQAQLYKKILPGYFTPIRSYKIATLKKDIEKLSKTVNEKAEALKRWEDLKSTLQLREEDFEEALDALQEGYNRSHDLKPPNLNVKVLKESAELLERRNILKGWISLERVNGLIDVWKNLVDCGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0U9</accession>
    <name>A0A6P8H0U9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intracellular protein transport protein USO1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548986.1">
        <property type="nucleotide sequence ID" value="XM_031693126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286564"/>
    <dbReference type="KEGG" id="aten:116286564"/>
    <dbReference type="InParanoid" id="A0A6P8H0U9"/>
    <dbReference type="OrthoDB" id="5974868at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1427"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="668"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="735"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="896"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1435"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031548986.1"/>
        </source>
    </evidence>
    <sequence length="1457" mass="167140" checksum="9DAB8C3CF72C714D" modified="2020-12-02" version="1">MEPELFSPEGERVISTIFEAHEMEELLYQDSEDSFTVCSEKVDYERMARQLAETLENKEREWRRLKTDYESYIMSLKANQKKDSDVELEVGRYEQGLPDKARVGPWQKTISDPIEESLKNQTKALLLMELISMELFYGMEDLLRDGGGAGVNKQVTXEKLYTLTDRELLLHSAETLLELTEYFFTKIGAAAQNGLADSSYAGKLLRVRSTLCRIKXNTDKAAVQFLSRLLDKQTTDTGVESSLVSFRKKSSEDSSTRSDGRLISVDEGVVLEGSESTNSREKLSHPLESSSLAEMEAENRALCEKNAEMRKRLNDSEKENESLNRKLSEVEKKLQDSQSILPKFASDSELVEKLKLAERSNQELISKVQDLEEKLNINLDKSLLKRIRDLEEKLKEHAIAEGNEEIVVNKVAVGLEDAVSDSMALRTRLHELEEQLKSRSNDDLSRCRDTEVGNDNRRLKEELKVLEEKLHDGNEARGLLDKERKIQDELIEELSAQLKTARAGSRELEEKVKILENCLKRSEATRIEESNEARRETKELKIKLQTAEHKNNRFLIKAEEFEGKLKEVGKLVARHKENERFLQTNIAKLQAENSLLKKDGDASNESKMEETKNNNAEESSPVEEEQQKMRETIVQLETEIFLKDQEILCLKNEAVDLMSEVSKLDTEYNELVAQRVKIEXDMKEQRNQRDEIEGELQGVLQECSKLRCDVLTLMDENNALRNKIESTSDVLKTSVSAVLSERNLLERDLQAVQERENELEKLTSDFETKNSKLQNDIDEREATVKKLQHDLDELLSEKSRLNFSLSEMKDEKVNAVEENEALQHDIKTLERNLLTLQESLTYCLNEKVALTEEISIKASELETLRTYSSLCSEEIKSMKTQIELYKETEGILNGRVEELKVSLDEWKEESLRMKEELGSIDDERKCLDKRIHEASRAIDQVKEELISLMHIVLSLQKELLCLVDGILVCLGIEGKQLDFSRQRLISIDSGYTSTATEASSERSSAGSESNIAESLSNCNLVPDEQCLVNPSEISIIRENKTEIFRFQEELKIKLLIIKDFLQQFKDNEALESIKSCEASNIESQSEISQENTGENLTEFPYLNKSEREKLTKLLSVLRRENGNEGTMYDLYSRLEEKLSGLSSHLATKELQICDLLKEKLKLQNELMKSKYGITLCEHCLSDPEKVNQSNELLRANLLSYMEDTARLESEIMEFAQYKAKLEEELNEVREQITELEDQIIEGQERETLPRMDVKTEPSIRASTVSCNDSSTSSDTTDASERKTKTEKRVTFDKMVVEPKQTSCLRKRKHRDIKNPEPTQDTRLQNTRMVADDDRKNSSFDEVDLCALLESIPIDPIPELKPKVEDKEVIEIVNRLSAYENMSFDDKVKFVVERQNSEDSSEKPDEVPNKNSYVIRYSGEGSNCKMCGLMKKKKTKESNSTKKTDEKSRKIKYTSHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H157</accession>
    <name>A0A6P8H157_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116286700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549126.1">
        <property type="nucleotide sequence ID" value="XM_031693266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H157"/>
    <dbReference type="GeneID" id="116286700"/>
    <dbReference type="KEGG" id="aten:116286700"/>
    <dbReference type="InParanoid" id="A0A6P8H157"/>
    <dbReference type="OrthoDB" id="9946013at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="30"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031549126.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35524" checksum="014D519F5BCC18B7" modified="2020-12-02" version="1">MRENIVDPKNSRDLMIATVGSFVFFIGIAGNILVVVAVWRKKSLHSTTNFLLVNLATSDITSLVFSPLLMIPKYVSFTNQGSLADFLCMFVFSYHVILTASIVSILTLTVLSVERYHAVVKPMNIGMRLREGTVKYAIVSVWVVGILLTLPMYINSYYKESSEDCRHTSYWTRAVSRTYQVFLILFVVVIAFAITGFSYFHIVREMYFKKNQQNLASNSAAERLRNQRKRRVVKLSLTVTLVFAVFLLPFAVLITMKYFNERAYRSYYKIAAILFFSEAGINPFLYAFQSAIFRHAFKHILKCSCRASNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1H7</accession>
    <name>A0A6P8H1H7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116287027</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031549498.1">
        <property type="nucleotide sequence ID" value="XM_031693638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1H7"/>
    <dbReference type="FunCoup" id="A0A6P8H1H7">
        <property type="interactions" value="1124"/>
    </dbReference>
    <dbReference type="GeneID" id="116287027"/>
    <dbReference type="KEGG" id="aten:116287027"/>
    <dbReference type="InParanoid" id="A0A6P8H1H7"/>
    <dbReference type="OrthoDB" id="5985483at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549498.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="61314" checksum="D20FBA78490B7A0C" modified="2020-12-02" version="1">MDFPKNSKKSKMNGFRKDQENKLLISYSGEEKPTDSDSDRVEPLELPPTRLRRPKSRKVRVSPNSKSSFSLWNFCQVLFVVVVIGSMVSMLWFTIILKTSLESMKKRVSILETSDRSTSKECLEQGKDLQKKLELLRGSSSGHLETAEKNFHLLFKRIEDLNSTVKYLQSKLKSPQSISSINNDIKLLKKAMADTSREITEVTDKFNRLRKIALLQNTNIKHLKIQLYNVSVQIAKLSGQPTPSPQLHTATQPWLLRVPGADSGSHSKTTLHAEEAEKLRLNITAQVRKDILKLVSLVRKSNKTVQSQVHELNVRLSGMANNVSEHMALIDSLIKTNVQHNDKTASKKNRVTSIPTDVPSQYKNLTKMVASLRNMFDEHLQRFQEMTIDIASIKLTVHQRVPPSTVSCNCSLDSIWTVLSKDKKMLHSLKTDLELLQESVQKLIKKDKEPTKAPDTTPENETIKPTTSSLPSTVTKATSSSQQPTTAQKNVSGTSSTTSKPASSTNATVAPTTEEEEQTLKENKRMTDEQIDLDSWNEDDTNQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1Z2</accession>
    <name>A0A6P8H1Z2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116287856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550409.1">
        <property type="nucleotide sequence ID" value="XM_031694549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287856"/>
    <dbReference type="KEGG" id="aten:116287856"/>
    <dbReference type="InParanoid" id="A0A6P8H1Z2"/>
    <dbReference type="OrthoDB" id="5990520at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027996588" evidence="2">
        <location>
            <begin position="25"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550409.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="63999" checksum="9BB390BA788C4B68" modified="2020-12-02" version="1">MMNILSRYRHIFLVLLVFLVCSECFPSKLKKPGNHRRTTRSHLKGHGHGKSMKKDSVRPSRQEVMAAVMHPGKLDIREEKELSQMQDFNKEYMNNEMAAETSLLANQGIDDDSALKISNIEALPGAFRGANASPKTKFNEMKDDTTSMSKQNVANFNPDEYMLDANSWPEYKIKDSDYMSRNFRVFPXPNEGEGGFQGGMMPYGARGKMEEGMEGPYGDGNYGFPQPPQMVSDQPSPPQMPDEGSQITSMPMNEANKVQRLVLKNNKHKNPQSETFNDMNAGPSKGSSDKDLLHPAEGGSGSGEGSGNSDPNVKENKAPLKPNGASETPKASNMKIHLKDDGKGVVGADKGGKGAAGPSTGGGGTEGGSGDASGAVGAGKTGSDGTEASATGTKSNSDSSQVLTSQPNPEQLVTSTKTPTPEKIKQKDDKNKTQNLSTSGKSDSTNGKTGSNQSNGTTGSNLSDGSSAKEITNALSQAQGNNPLGQFAEFLKSKGITLTINKDKATATSNAQTPDKESQPNSTTAQSAPPPLSMLASVLPTTGESLSQPSSNTNSITXANGSQDSHASPNNLDNAVMNWQNIAPQNAGQIGELFLRQSTKQGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H365</accession>
    <name>A0A6P8H365_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116287514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550058.1">
        <property type="nucleotide sequence ID" value="XM_031694198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287514"/>
    <dbReference type="KEGG" id="aten:116287514"/>
    <dbReference type="InParanoid" id="A0A6P8H365"/>
    <dbReference type="OrthoDB" id="382013at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028050376" evidence="4">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550058.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34247" checksum="2B1D82489810BBE5" modified="2020-12-02" version="1">MTSIPLLLVLLIFPAHLIIHGRVECVNSKPIARIIKRYLNRPSLPVKENQAPWHVFIPTVRCSGALVHGRWVVTAASCFSQDSEQDSLPKFRVMRVRSDDGFXNLETPLLVRIGNHHXDVQSAGEDMIPVLEVIIYPKFNDKTLDGDLAILFLVREPILSKVSKINMLSRGLVLPDLNDTNYDRYYGTLTVTGWGHKSGTRNPFPVLHSDLVSLTFTNICNDTTNYNGVVTSNMICSEGLACSVDGGSPLVAQDKNISKLLGVFSWGRSCALDKKQAVYTRLGSDILQWLINRIKITAGQPSSVANNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H432</accession>
    <name>A0A6P8H432_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116288429</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031551114.1">
        <property type="nucleotide sequence ID" value="XM_031695254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H432"/>
    <dbReference type="FunCoup" id="A0A6P8H432">
        <property type="interactions" value="2223"/>
    </dbReference>
    <dbReference type="GeneID" id="116288429"/>
    <dbReference type="KEGG" id="aten:116288429"/>
    <dbReference type="InParanoid" id="A0A6P8H432"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05605">
        <property type="entry name" value="STKc_GRK4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000074">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="13">
        <location>
            <begin position="58"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="200"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031551114.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="66210" checksum="BAE568F24672B98F" modified="2020-12-02" version="1">MELENIVANTVYIKARESKNKGRSKKWKELLRFPHYTLCVKDEFRSQIPQEYDKICEKEPIGKELFRIFCATDPRLQQAIDFLDSVEEFIKAEATNRPEKARDIVRRHLQPPDNNRDFVEEEEITYRVGGVLDDTAEKAYSVVSRSSDEEFSINLFNDAVREVKDYLSDFPFKKYLDSMYFARYLQWKWLEKIKVTKKTFRHYRVLGKGGFGEVCACQSKISGKMYAMKKLEKKRIKRRKGEAMALNEKTLLEKIDSRFVVSLAYAYETKDALCMVLTLMNGGDLKFHVHNMGNPGFEEERAVFYAAEVTLGLIHLHSQRIVYRDLKPENLLLDDDGHVRISDLGLAVQIRNGDTIRGRVGTIGYMAPEVIKNERYTFSPDWWGLGCLIYEMIQGKSPFRARKEKVKREEVERRVKEDTETYSDKFSSYARLICSQTLQKDPATRLGCRGDDVRKHPFFRSINWSQLEAGCTPPPFTPDPRAVYCRDVLDIEQFSSVKGVRLDESDEEFYKRFASGSVSIPWQKEMIEMGCFKELNVFGPNGTPTPDLTGEAPPEPPKKSSCTCSCFGDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4Q5</accession>
    <name>A0A6P8H4Q5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysophospholipid acyltransferase 5</fullName>
            <ecNumber evidence="16">2.3.1.23</ecNumber>
            <ecNumber evidence="17">2.3.1.n6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116287845</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="16"/>
    <dbReference type="EC" id="2.3.1.n6" evidence="17"/>
    <dbReference type="RefSeq" id="XP_031550401.1">
        <property type="nucleotide sequence ID" value="XM_031694541.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H4Q5">
        <property type="interactions" value="984"/>
    </dbReference>
    <dbReference type="GeneID" id="116287845"/>
    <dbReference type="KEGG" id="aten:116287845"/>
    <dbReference type="InParanoid" id="A0A6P8H4Q5"/>
    <dbReference type="OrthoDB" id="5974730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF14">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031550401.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53255" checksum="B9F4B7F9226C32CC" modified="2020-12-02" version="1">MADYETVGVGDISFLVQKTGLSDPSLRLVIGLLAAYPLSVFYRLVLYRKNAIIQHLYFIICGLALLIFNYGWGAKHSVINISMVYLVLLVGGSQAATVLAVFVLNFTYLITGYMVNATGGYDVNWTTPHCVLCLRLISLAWDYYDGGQDQETLSEDYKKTALNXLPSLLEVFGTSFFMGGVLVGPLFPIKHYIQLVEGKLIDKEDDNNSCIAAGFKRLSAGVLYLGLYATLGSFFPDEYLLSQDFKVICLLFKTIFNGGMLQSVHLSIHPAGHPSVSPSHSSIEGSCIIPGLAYNGKTPQGELTWDGLRNIKLSIYEVSYTFQHIVECFNINTNKWVFRYVFKRLRFLGNKDLSHFLTLMFLAVWHGLFLGYFIIYAMCITLSNKRWADMSIALRALVIAISWPIRFCGFGYTIIPFNFLTWDKMNEVFYTTYYTVPAVLLAWFILYPIVILPIFKAVSRKTGDKERLKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5D3</accession>
    <name>A0A6P8H5D3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116288833</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="RefSeq" id="XP_031551579.1">
        <property type="nucleotide sequence ID" value="XM_031695719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5D3"/>
    <dbReference type="FunCoup" id="A0A6P8H5D3">
        <property type="interactions" value="1276"/>
    </dbReference>
    <dbReference type="GeneID" id="116288833"/>
    <dbReference type="KEGG" id="aten:116288833"/>
    <dbReference type="InParanoid" id="A0A6P8H5D3"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="74"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031551579.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55175" checksum="3AF7A34AFBF06D8A" modified="2020-12-02" version="1">MPKRNNKRKASDSKLQSTEKQNHSHDFLAEEESSIRANLLSWYDQNKRDLPWRRYASEEDPNKRGYAVWVSEVMLQQTQVATVIDYYNRWMEKWPTLKDLAAATLEEVNECWSGLGYYSRGRRLHEGCKKILEELDGNMPTSASKLQKELPGVGRYTAGAIASIAFKEKTGVVDGNVIRVFSRLRAIGADTTTNVVIDKFWQLANSLVDGERPGDLNQALMEFGATVCTPKSPSCSNCTLNEYCRAYKQVEEYNKKSTELLNAKLNNNKLSKTFEILDIENCELCLSSEVPWDPALGVFNYPMKPKKKETKEEKFATFIVQRNNPDDEQQFLIVQRPKTGLLAGMWEFPNIELTLEAKSNTVTNDFLSEKIGLSKLDNRKEIGEVNHKFSHRYHTYIVESYVCEDTENDLVESTKLNGQASRWVTKDEFEEAAMPTAMRKILKLYEDSLKTISQAAKKRKLGNASSQVKNQRTMDSFFKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6L4</accession>
    <name>A0A6P8H6L4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551131.1">
        <property type="nucleotide sequence ID" value="XM_031695271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6L4"/>
    <dbReference type="GeneID" id="116288476"/>
    <dbReference type="KEGG" id="aten:116288476"/>
    <dbReference type="InParanoid" id="A0A6P8H6L4"/>
    <dbReference type="OrthoDB" id="5944938at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027535930" evidence="6">
        <location>
            <begin position="18"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="120"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="243"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="339"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551131.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="48820" checksum="1AD9D01572DAA74F" modified="2020-12-02" version="1">MKFLGLLVVLCARPLLCQEQVRLAGGKAPGEGRVEIYHDGRWGTVCDDGWDIRDAKVVCRSLGQPNATYAIQGAFFGRGSGKIWLDDVHCRGTESSLSQCSHRSWGFHNCGHGEDASVVCGEPSIVKINITDLSGVITSPGYPQYMRRANYEWTLRPPVPNTLVLISFKEFDLRRHDRGKSKVTIEDSNHVQLFQSENANFGQFAVRMSNSPGTLRFYSSFSRLNGGGKGFRLNYLFIGQGFCKADWNVTVTAGISTVNISWPPPSASSQNDTSYSYLVLYNSTNTGVQSFTKLKNLTSITIDNQFQSDNFSIQVVAFDMRNHSINSCPKIFRKTQAGVRLAGGKAPGEGRVEVYHNGQWGTVCDDAWGFNNAKVVCRSLNLPITDVLSFRLARFGLGVGRIWLDNVGCTGSEPSLYQCRHNGWGVQNCGHSEDASVVCGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8P2</accession>
    <name>A0A6P8H8P2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NF-kappa-B inhibitor-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inhibitor of kappa B-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551881.1">
        <property type="nucleotide sequence ID" value="XM_031696021.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H8P2">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="GeneID" id="116289143"/>
    <dbReference type="KEGG" id="aten:116289143"/>
    <dbReference type="InParanoid" id="A0A6P8H8P2"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551881.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="43380" checksum="D1D2C01A3BC612E0" modified="2020-12-02" version="1">MADNDGHIKKKNVERLFRYVKDGRLKRVRSLLKRHKVDLNFQDGKKRTALHLACILGEDAIVNVLLQHGASKESKDIDGNTPLHLALNYALQVLEKRIYDELIIPLLHSNPNIENDSNDQGESPRDLIKRFKKELKRKREDRKIXEEEEELKREKSRESKEWNEKLFFELGNDDVDFTGFTRKYDDKDSRRETYDQWADGIDREYYYRKKCLHSKQKEKICEEKIRIEKENEERTRMLEENHRKYLNDVCKKRKQLRLEELRSNYESRCTTVFAQDMITKLSFHDIPWPCKGTLEEMIEMISKWICHDEDGKKYLKEQQIRWHPDRFFQKCGDRLIEDDKETILNYVKQLSQGINMLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8T3</accession>
    <name>A0A6P8H8T3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-specific adenosine deaminase 1</fullName>
            <ecNumber evidence="8">3.5.4.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-specific adenosine-37 deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116286732</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically deaminates adenosine-37 to inosine in tRNA-Ala.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA(Ala) + H2O + H(+) = inosine(37) in tRNA(Ala) + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50968"/>
            <dbReference type="Rhea" id="RHEA-COMP:12855"/>
            <dbReference type="Rhea" id="RHEA-COMP:12856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ADAT1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.34" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031549172.1">
        <property type="nucleotide sequence ID" value="XM_031693312.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H8T3">
        <property type="interactions" value="1749"/>
    </dbReference>
    <dbReference type="GeneID" id="116286732"/>
    <dbReference type="KEGG" id="aten:116286732"/>
    <dbReference type="InParanoid" id="A0A6P8H8T3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A to I editase" evidence="13">
        <location>
            <begin position="61"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031549172.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="60591" checksum="F09649C14B5844F5" modified="2020-12-02" version="1">MIMVLWQEDENFGLNVASSCCSLYSSVGKKGKPQKGREWTLLAAVVMVKQQGDHYSLEIVAMGTGSKCIGQSKXSERGDVLNDSHAEIIARRGFLRYLNKELADTYQGKDXTIFDFQEDTNLCLLKDEISFHLFTSHTPCGDASIFPKPDCGIKQNTNSNNTNEVEPNKLTQKKRRNHTTDEDAREPKKPCLLSKKREKDDSKEACQVAQSIDNSTVDLLGTNECCLDNNTDDETCLSHLSNDENVCQHILNKFDRREMIKDIRKTSSXTSSSSGSVINEQKSLEHGSKLDKQQQKDIFRTGAKCVPGEPQDPLQPGIDYHHIGVLRTKPGRGDPTLSMSCSDKILKWNVLGCQGGLLIHFLVAPIYLSSIILGRCPCDVNALQRGLYGRAKDKMNXFKLCFGFKVNAPKFFITDVIFKDGKEGVENEMGKDVKISPSSAAIIWIKEPPIYEVGVNGLRQGITKGDLNTLKARLSICKASLFKEFNNLVEIIPDEKIPFTLRSADLKTYSQFKNAATKYYEMRTQFMNAFPAWSLKPKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9R6</accession>
    <name>A0A6P8H9R6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger CCHC domain-containing protein 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116286994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549462.1">
        <property type="nucleotide sequence ID" value="XM_031693602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9R6"/>
    <dbReference type="GeneID" id="116286994"/>
    <dbReference type="KEGG" id="aten:116286994"/>
    <dbReference type="InParanoid" id="A0A6P8H9R6"/>
    <dbReference type="OrthoDB" id="10038672at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057809">
        <property type="entry name" value="ZCCHC24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23490">
        <property type="entry name" value="ZCCHC24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031549462.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13919" checksum="04C6C33C4B93E9FD" modified="2020-12-02" version="1">MTSANEKKVAVANSEKYFGCVILQQHFHRAKMSDKKTPYQGKRRVFGEFRCPSCNRMWQSGNSWANAGQKCKTCDIMVYPYKQRPLERKDSDDEDFIDESKPHLQHLCEKCIRLGHSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAC7</accession>
    <name>A0A6P8HAC7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 120A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM120 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549642.1">
        <property type="nucleotide sequence ID" value="XM_031693782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAC7"/>
    <dbReference type="FunCoup" id="A0A6P8HAC7">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="GeneID" id="116287141"/>
    <dbReference type="KEGG" id="aten:116287141"/>
    <dbReference type="InParanoid" id="A0A6P8HAC7"/>
    <dbReference type="OrthoDB" id="2015098at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012926">
        <property type="entry name" value="TMEM120A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 120 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07851">
        <property type="entry name" value="TMEM120A-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031549642.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="40815" checksum="8380897D37F1106B" modified="2020-12-02" version="1">MAAIAEISTLQEWDEEWRTVEDDLLKFKTGQFLEYQKKMDEFHKSQKSCLSMVNLMKRKINDFDKALKRLEKQNDTPESKKLVVELRYRIELLENKIKEVQRSLPSSAGSFLRLCLGDINVSLYNKKLEYKDNYEKFKLKMTILCTVFACFNLVCNYRLTDSLFHGVLVWYYSTLTLQEHILIANGSRIKGWWVLHHYFSILLSGFLLIWPDGIIYQMFRRQFFLFSLYLSFVQLIQFKYQSGVMYRLRALGVSHGMDVTVDGFQTWMWRGLGFVLPFLFLGYVFQFYNAYTLVALYYHPDCREWQVMATGVTFFVLFFGNFTTLLYVLKQKMTKGQKMRVPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB60</accession>
    <name>A0A6P8HB60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290737</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553699.1">
        <property type="nucleotide sequence ID" value="XM_031697839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290737"/>
    <dbReference type="KEGG" id="aten:116290737"/>
    <dbReference type="InParanoid" id="A0A6P8HB60"/>
    <dbReference type="OrthoDB" id="5958283at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553699.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="47141" checksum="901895E25FF76120" modified="2020-12-02" version="1">MMKASKNELDNFXENLFNEERSRFEYEFCGRAPIRHVKRFMSSGLLLKGFALAFGXWNPRRRWRAMFALIILLVDVYLSIQTAIYVFVCPKLRAQRTLVIWFCANSSVNITSKSVEDTDILLXVRMKELLINDAVLDIGRLLSHLTFFRSVWMLSKELNCVKQENTLPLVNPWGWIKLNCVLLFFWCALISGIVLIMFGISSSNYSSFVAHGVYSASLWTSLLTCWLFSTLILSMETLVTRCTDDIMTAEHLDDIIKKHQQLCKIIFGTSNAFKLWFIVHWVLYTIACVFWVATFTSFSDLMHSHFQKIFFYEIILGIYLYVFIYPCYRAAQLTGKCQQMLANFNLMTEADWHDNHPFRQRSQLHLFLQYASYADCGYRVGRYTFGSMAVFFSSVLAMVGTGLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBD3</accession>
    <name>A0A6P8HBD3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor AP-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552926.1">
        <property type="nucleotide sequence ID" value="XM_031697066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBD3"/>
    <dbReference type="GeneID" id="116290086"/>
    <dbReference type="KEGG" id="aten:116290086"/>
    <dbReference type="InParanoid" id="A0A6P8HBD3"/>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
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    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
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    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005643">
        <property type="entry name" value="JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03957">
        <property type="entry name" value="Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="280"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="283"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552926.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40827" checksum="DEB325A68BA3AFFA" modified="2020-12-02" version="1">MGDHVYRSYDNMDVLFYEQQTPTQSGGNFNKYDKSAMRLNLRPTQLTGQENHRPINGKSATGMFHHSPDMGIFKMVSPELERFIGSNTGLTPKGNPVQPSSPEFPLFSLVSPEFEKILASIQNKTPTPTRILREGNSVAKQREVYVQGFAEALQHIHDQQQHTHLEHGNNEHVKIQYQQQQMSVPGTVSYGWTDRRQDSHQNYESMSKENPQCDMEAMHYVSSVEPSEDSQNALDSTYNQMEQINEPNEHKLDETPLRRNQNLNVLPLPPIDLELQEIVKRERKKQKNRVAASKCRRKKLEREAQLEVRVQQLKEKNIELNAVASALRQQVGELKQRVLEHVAFGCQLPTVTTAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBH4</accession>
    <name>A0A6P8HBH4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">SH3 and PX domain-containing protein 2A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116289670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552478.1">
        <property type="nucleotide sequence ID" value="XM_031696618.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552479.1">
        <property type="nucleotide sequence ID" value="XM_031696619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBH4"/>
    <dbReference type="GeneID" id="116289670"/>
    <dbReference type="KEGG" id="aten:116289670"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="235"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="579"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50195"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552479.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="87843" checksum="BCFC22E3CC75B34F" modified="2020-12-02" version="1">MSLSAVSDITVERVVKQKSRKKHFVFSIQVEWKDGLIIRIYRSYDDALNLQDKLRKMDEFNSYLNNEAAEYRNGYSLQDKGLFGKVTIKTSKQARRRMVEVEEFLKSIVHLPSHISMADVVVTFFRPVPDDLMFVDPERYEESLKEAKGTRQKNDPLHISEPILLDQYVAISDYTRMNKNDLNLKAGDIVEVIYKADHGWWFVDLDGELGWVPASYLESRDGDMDEQIMETFEDGQEEMYIAMGKYDAEYDDEIQLEIGKLVQVKQKKMDGWWLVKCNDRIGWVPCMHLHELSTSSTKSNAREMGREKALMTMNNIFAITDRRRTWNPSLPPKRLSTFKSTVRRRRFEKEETIQEEDEDEEKPSYMNIEFHKKIVKTTTKIPSNDNDEEAGPSYINLDFHKKDNTKANKKKKNVVLKDEEKEKGPSYINMEFHRKKDQAMAPRQRVRRRRDEDEDLVEIDFDKMKKFNSQSKETSSKAGLVENEIPKDNGSGNEEGNSMKDEMKKVEMKKVEMKVENSLADSDSNEYEFPPSFSEKPLNTEGLGQVPENVTLQAKSQKKLKFDLKIHIPEPTDETDMTSGSNIYLAVGDYTKESDREVNLQTGTSVEVLEQSEGGWWLVRTKSLTIGWAPSNFLEKISKEELERRKELGLESPTRSPLRPPKSPRVHRMAKHVSTEQKFWNFMRKSDQNNATCSIVDEKEVCRVDDSRAQQLTVMDVNGNRLGEYHVHEPSKHMKKSYICDSNTGVCKLEQNEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBY1</accession>
    <name>A0A6P8HBY1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neuropeptide FF receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553146.1">
        <property type="nucleotide sequence ID" value="XM_031697286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBY1"/>
    <dbReference type="FunCoup" id="A0A6P8HBY1">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="GeneID" id="116290278"/>
    <dbReference type="KEGG" id="aten:116290278"/>
    <dbReference type="InParanoid" id="A0A6P8HBY1"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="46"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553146.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44977" checksum="34BF4721C37B2444" modified="2020-12-02" version="1">MKMNVIVNNTNGTSNSSSTTEPTENVTERTVRLTFYVATFVLGMIGNILVMVILGKKSKRSIHEMFIFNLAVSDLTFIAFCLPVNGYELFEIIPKIEFYCRFIFLMQTITYFISIYTITSMAIHRCYVIVNPYKPKMSTKSASVWIAFIWLISLIIVIPIAVVNQSVNDECQENWLDPYHAKVYTAALFVLQFLLPLCIIAIAYIWIGIYLVMNKGPQTSIGGRRRTASHQKKRRENKQIITTLAAIVILFTICLLPGQIAWMVRDFGSPKQQNDIEVVFKFSDILDFIHACVNPIIYGLLTDKFRKDYKDVLAKIFTCGKTTVVPGTNDTTFQMEASNNSGQQAANPELPSDVYSVDIKGSLEHTNGQQTCSDDIKGSLEQTNGQQTCTNNHEDFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC90</accession>
    <name>A0A6P8HC90_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbohydrate-responsive element-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553251.1">
        <property type="nucleotide sequence ID" value="XM_031697391.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HC90">
        <property type="interactions" value="1469"/>
    </dbReference>
    <dbReference type="GeneID" id="116290373"/>
    <dbReference type="KEGG" id="aten:116290373"/>
    <dbReference type="InParanoid" id="A0A6P8HC90"/>
    <dbReference type="OrthoDB" id="6022628at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000028">
        <property type="entry name" value="MLX interacting protein like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="1166"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553251.1"/>
        </source>
    </evidence>
    <sequence length="1394" mass="155635" checksum="342FC9ED81CF8D87" modified="2020-12-02" version="1">MDTRDILAQLLSSEDSISSTGTLGADGQPVKKDLSTHIEDNLSRLFECLKLEYGRRILVSPKWKNFGSQKLQLSEKTRLNNAIWRCWHIQYQKNKKPLFCQFVSPLSSEEREPPKKPLAIILQGRYWRRKLDAIAREYQKWRTYYKQKSQEAEEEAQQERLRTLSTSSGDDEVSHGSPMTQVVNLMDMQLTTDNMVHSHPDTLFTTKTAVRSQAKETIPEASISEITFQPSLDSLQPNLDEFSKHIESLVDFLTENQPNESYQVPFSTSSRESLQFGSNQLTPLNTSLTSQAPSMMSFQGPQNNVEMMDQSQNFELYSIPTGVGQENQPIQQVTSLQQDQDFMDTSENFQQYTMDYDSQMNLQSFSPSSGQPLSHEGIPLEHLHEEVEQDFFVNQNQAESTVVQGTTLTSPTQKSPIPVLPQSPAQHIPGSHLQDPKLMTSGQTRHLPYRHSSGNLQEYGTSPVRKGRLPRNVSDNQLSMIDSSQLSTLGLPFLHSQEQKIPAQVQFPNLVAHLQSSNASHSESLSTGTQAKRPRIPRNMSDSGLYDMLRTSKSHLPTSYNSSLSQFSSAMATSPPPHSSQQTPLEQIRAQAQAGQAQSQICPAPFQQTPASQIKHSTGRSRKGKLPRNMSDSSLMYMSNQNSSXNLKGFPTHRRKSNDSLQAMSPPLSLPSAHSVLSSSNQAVDPLTRLQSTHPVYASTTLASSQPFDVTKQVPVPPISSSVTGASAHEQMLLFNELQNQNQSSMASSTTPNTGLTKNVYSFAETPKTGSLLSQLLLQSEGSPELQKMETKESQNQMVKQLLQVVQNQSQFTSHKPISSQELMLAAMKSTSTNQQSTELMSLLQGTSPQQRGTDLVGTTSSSQLYHILPQHDQQQQQQQQKSLQLLQQQQQQQQQPLVQITQQRKAKAPQQATQVLEQKLQQQLLQQQQQLQXQATENQKTSQLISALKSTTQVLQQQLAQPQQLQHLQQHAVHPQLPQGAIFDSKQTMSARQPNVTIQPRSEGAATITHKVYQGPVLIAPHPKVSSNSIQGAQASLKSTLVQPVQGVTAEVQPSTTSLLSLQQMLDDSTSTQVASPSGLKVESSTLGFKTSGLPQQSTPTITSSFSFPQALFTTGTTTTAAPTTNELTAITGDLLNTVSTSASPQTPKFTRPISAADRENYKEHRRQSHITAEQKRRFNIKVGFDQLSNLVPSLAHQKNAKISKATILQKSVEYTMKLQQEKERMMEEEELLKKEIQSLHSSISACQQQLPASGVPLNRQRSDQMLTLYNEYVKMRTQENFKFWILGVIFRKMFEVYNQNVSTSTWKEFCANILSWLDEHCTLPNLRPAVLSALRDISRSTSILTNPSKFPDEIKHYIATNTNPTVISDTPSSSPTKRNIQGRNYFHDDTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCN4</accession>
    <name>A0A6P8HCN4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116290494</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553396.1">
        <property type="nucleotide sequence ID" value="XM_031697536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290494"/>
    <dbReference type="KEGG" id="aten:116290494"/>
    <dbReference type="InParanoid" id="A0A6P8HCN4"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF15">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="3">
        <location>
            <begin position="155"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031553396.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56129" checksum="9130F1738B31EA37" modified="2020-12-02" version="1">MEVYMRQRVNQDYLTVVARLPGQNNVQLFPQEYLYWMXPGSRVLEFHLTNNISRKIALGSEITLEAVYKFCCKGILCPSCPLVLKLEAFKQTIMVNRSLEMTCEEHKMRHKIEAVVQPGNYSIYIIYDFLAGDTHYWKRKRTIAESIQVSDSTRLQCSFRDGRCPGWIVTSQDISCQWSLEKPGKTEDKIIYLGDFIALTTPGISSLESPSMPWTSNYKHIRMCAEFSYLFPSNTSSRLEVYRKTSSSEDLLWLIKGHHGIKWQRANIPFKSKENFQIILKGVSKTNGSXSLAIRGFQVTSRSCRHRPEFAEPGFVCEVTDFQCANGQCINKHRRCDGIHGDCPDGSDEKGCVCQIGYFTCANQKXIHHNKLCDEKRHCSGGEDELHCDKKCPGHQCLDGTCSSCGQQSHCEEKRHLSCDAFVTKQMANSQRCQVQRGICGFHNELCGFQNDTKGILSWDSFKPLDYDTELRKQNLSRKYDHKSLTDKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCP4</accession>
    <name>A0A6P8HCP4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116290015</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116290015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552848.1">
        <property type="nucleotide sequence ID" value="XM_031696988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCP4"/>
    <dbReference type="GeneID" id="116290015"/>
    <dbReference type="KEGG" id="aten:116290015"/>
    <dbReference type="InParanoid" id="A0A6P8HCP4"/>
    <dbReference type="OrthoDB" id="5970391at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552848.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27128" checksum="658EE9C26D5BCFF3" modified="2020-12-02" version="1">MPNRHVFTVYDPLAELKKHHANVFIKQYTMAERPRFRRQRSQTVPSIGNVQVKNSSSTTSISQARMTHVPVRQTRSLDFTIPNKTRPRSYATGQHTVSFSGNAVETNTKRFHGPRHSLSHSKVSTLDLPIRKTSKEESATIATRQTKSKSIPFDDKSSIYSIVKTRSLALKWYRGNTKTTSTKPKRKKSEPLPTINDKETISLCQAKCSPQFAEAMNLLQNDDNPIEEDIEGELSVLCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFB0</accession>
    <name>A0A6P8HFB0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Adipolin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adipolin/erythroferrone family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554451.1">
        <property type="nucleotide sequence ID" value="XM_031698591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFB0"/>
    <dbReference type="FunCoup" id="A0A6P8HFB0">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="GeneID" id="116291420"/>
    <dbReference type="KEGG" id="aten:116291420"/>
    <dbReference type="InParanoid" id="A0A6P8HFB0"/>
    <dbReference type="OrthoDB" id="5969874at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052136">
        <property type="entry name" value="Adipolin/Erythroferrone-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019:SF5">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028021252" evidence="9">
        <location>
            <begin position="34"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="10">
        <location>
            <begin position="173"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031554451.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35576" checksum="5172819BC7E02480" modified="2020-12-02" version="1">MTTFWLGKSLVSSLTGVFVVVLLVLLHLSPVKTSPTNKTSCVESTVSQGDRNLARRLPICNSTDPQSTEITNDNRKLDPFGSWSNFLGHATNSRNSKKGDRGKGKPRNKTPSTKKSTHPCPPGPPGPPGPQGPAGAVVTEAHMMMEFRNLVRESAQKRSRRLADNISLMASGIPDLVSAFHVELRNEIQIARKTLHELNNYKSHVGSFGTFVRGNDIEYKNGRYIARYTGVYQFSCSLHVLRARDANLRPRDSIKLQICINSLCDHNTSLLTVTGVNSNSKVFTISLHGILLLKAGQYTSVFVENSSGNPITISSQSSFSGILLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFQ1</accession>
    <name>A0A6P8HFQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-2-syntrophin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116292134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntrophin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555244.1">
        <property type="nucleotide sequence ID" value="XM_031699384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFQ1"/>
    <dbReference type="FunCoup" id="A0A6P8HFQ1">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="GeneID" id="116292134"/>
    <dbReference type="KEGG" id="aten:116292134"/>
    <dbReference type="InParanoid" id="A0A6P8HFQ1"/>
    <dbReference type="OrthoDB" id="9975356at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031555244.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54765" checksum="2A2CF4374267A642" modified="2020-12-02" version="1">MAEKSATLGYLHMQVNRGELQKVRVKLSREALTIQKEGGPPYASPNAQQATGSGNNRREVRIARRKVGGLGMSIRGGKESNLPIAISKIYKNQAAAATRQLYEGDIIVEVNNQDMTNATHDEAVVALKESGPEVVLVVEHPSTGSLGRQEKQANGIVRSIEESSERQRFMNSTSSDYGETDSMSSMQSWTDNIILPLTFASISRYKTGEDNLRSNAFEVSSMDGGASVVLYSENSGELLSWYTAIKDRISMLLDQSINMSNSSLPSAEQIIHMCWVWERIQSTTHWNVWKRKFMTIKGCEIALFEMPPVVTRDWLQSEITFNLMEIVFHVCREDELLDKRENCFYIQTCTGESCYFSVDTQADCTDLSNSVHRATHISVAQVECRTFPGKWHGRAVKLVLDLKRGLRLYSAEDRTLLWQYRFSYLRGSSDDGHKKITLLFSPAPGGPFDRQELEFTNMQLVLTVMHAFYAAKVAQVDPKFVMENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHI3</accession>
    <name>A0A6P8HHI3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555296.1">
        <property type="nucleotide sequence ID" value="XM_031699436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHI3"/>
    <dbReference type="GeneID" id="116292171"/>
    <dbReference type="KEGG" id="aten:116292171"/>
    <dbReference type="InParanoid" id="A0A6P8HHI3"/>
    <dbReference type="OrthoDB" id="10051855at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028264821" evidence="10">
        <location>
            <begin position="26"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="159"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555296.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="26194" checksum="D7574FE547BB0855" modified="2020-12-02" version="1">MVSFRTSTILLAVFSFLACVHLNKSLLPIRLVNGTRPNEGRVEVYYNGTWGTICDDSWASSAPCCGRFGQGNGPILIADVHCNGWESSLGQCYYQGWGINYCWHNEDAGVVCGGNASVATTFRPIVTTSSPALVRLVNGTSPNEGRVEVFHNGRWGTVCDDGWNITAANVVCRQLGLPPASSAPGNARFGQGWGPIYMDDVRCYGWERSLAQCYFRGWGNHNCGHGEDAGVVCGSAPTTDPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIC5</accession>
    <name>A0A6P8HIC5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552320.1">
        <property type="nucleotide sequence ID" value="XM_031696460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIC5"/>
    <dbReference type="GeneID" id="116289514"/>
    <dbReference type="KEGG" id="aten:116289514"/>
    <dbReference type="InParanoid" id="A0A6P8HIC5"/>
    <dbReference type="OrthoDB" id="10028859at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028021645" evidence="2">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552320.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="56458" checksum="1D9D1A4B76A804F6" modified="2020-12-02" version="1">MASFHKISAVLICSMVLLTVQGRVHKKKDELIHPATPIREGACVVGEWQGQESSSIPTIPTLMWFHTPSIIRIEPGHYQATGRIIKANYLKERLTLKDINFNTAERRNMESLLKLDILADTFHIEGEVTFYAIQTVKIYARQIVAAEGSRIVFATPDWIQDFATPGVQGNGVGTNGDNGKDGKDGPEVEVLSDAIHGELDISSKGGNGHKGQDGGNGRPGTRAADKGDKYSDWKWCPRGGWVSWSMRGVDLYAEASKRCRNRNRGSEYGNRGGNGARGGNAGTPGQGGNAGSVTLRYRMLNGRVKANVCAGTGADAANNGRGGNGGSGGAGVKGIQCYVRRSSSYDSEVQTFECHMKHPRLDTIRGANGRKGASGTTPNVKGQDGTVSDSAISKSETIDEESKNAFPENLLLLIRRKAVDLLLGDSKNKEGKDALQFLVRITTGRTDVEYIMKDAQRKLAFLDKDGFDIFGKNSLFAPLIKWEELQKDVNRIKEAAKIYEDAFTNIMNQVNDEENFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKP6</accession>
    <name>A0A6P8HKP6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116293104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031556361.1">
        <property type="nucleotide sequence ID" value="XM_031700501.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HKP6">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="GeneID" id="116293104"/>
    <dbReference type="KEGG" id="aten:116293104"/>
    <dbReference type="InParanoid" id="A0A6P8HKP6"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031556361.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55967" checksum="3344F349B4D60C91" modified="2020-12-02" version="1">MAANTPVFKLADHTLSVSMSMFATNRKRLCKKLQENGEVPKGAFVVLQGGEQKQRYCTDTDVVFRQESFFHWTFGCLEADCLGAVEVDTGKSILFVPELPQEYAIWMGEIYPKEHYQKKXDVDEVCYTNEIAEVLERKKPSLLLTLRGLNTDSGSICREAAFDGISKFKVNNTLLHXIIVECRVFKTPQELEVLRYVCRVSSEAHKELMRRIRPGMTQFQMESLFQHYCYSQGGCRHTSYTCIGATGKCCATLHYGHAGAPNDQRIEDGDMCLFDMGGEYFCYASDITCSYPANGKFTEKQRQIYEAVYKSNRAVMAAVKPGVSWPDMHRLANRTNLEELKRIGIVRGDIDEMIKHHIGALFMPHGLGHFMGIDVHDVGGYPEGVKRIDEPGLRSLRTGRTLEENQVLTIEPGIYFIRAVLEPALSNPEISHFFNRELVEQYWNFGGVRIEDDIAVTADGMELLSCVPRTVEEIEALMAEGRDLTPHFTEPVASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKT2</accession>
    <name>A0A6P8HKT2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 48-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553302.1">
        <property type="nucleotide sequence ID" value="XM_031697442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKT2"/>
    <dbReference type="FunCoup" id="A0A6P8HKT2">
        <property type="interactions" value="4122"/>
    </dbReference>
    <dbReference type="GeneID" id="116290416"/>
    <dbReference type="KEGG" id="aten:116290416"/>
    <dbReference type="InParanoid" id="A0A6P8HKT2"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000543">
        <property type="entry name" value="WD repeat-containing protein 48 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="633"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553302.1"/>
        </source>
    </evidence>
    <sequence length="705" mass="79209" checksum="4099F64745E9B3F8" modified="2020-12-02" version="1">MAAGRPPSAHSHSQTTHRRKVSVSFVIRDEEEKRHRSGVNALQYDCNTTRLYSAGRDSIIRCWNVKHERIKDPYIASLEHHTDWVNDIVLCRNGKTILSASSDTTVKVWDASRGFCMSTLRTHKDYVKALAYASDKEQVASGGLDKQIFLWDVNTLTALTATNNTVTTSSLSGQKDSIYSLAMNRSGTVLISGSTEKVLRVWDPRTCGKVMKLKGHMDNVKAITIDADGTHCLSGSSDGSIRLWSLGQQRCIATYHIHEEGVWALYANHSFTEFFSSGRDKHVFWTDMTKDDSSVLLFVEEAPVLKLEYCPDPMCLWTATTNSNINCWPITLSSLQNDTSMNMETNETEPTPVCTVKRMVIKGASSIKKFNILKDRRHVLTKDTDDHVALWDVLKARKVEDLGCIDFDEELKRREQRIYVPNWFSLDIKTGMLTVTLEESDVFCAWISLSDVPGLEPKTTDYKALDIKHVNYGVLLLQALLEHWPETHSVTTEDTEQGRANTPEDGRDASASDININVEPKVIVGNGFYSIPDHTPLIFSESSGTGRTLFRLLAIDASGENEGYLLSETVPSWVVDVTIKRQTPKFPKIAFFLQPHTTSSSKSLKRDRLSASDMLHVRKVVEHVYEKVIGWDNTSHTSSTPSTPTGGQIPPTYDNEEDRSSIAESRVELLCQDQVLDPGMDLRTVKHFIWKGGGDLVLQYRLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLC7</accession>
    <name>A0A6P8HLC7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031553415.1">
        <property type="nucleotide sequence ID" value="XM_031697555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290512"/>
    <dbReference type="KEGG" id="aten:116290512"/>
    <dbReference type="InParanoid" id="A0A6P8HLC7"/>
    <dbReference type="OrthoDB" id="10007527at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052825">
        <property type="entry name" value="CCD-Prefoldin_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031476">
        <property type="entry name" value="DUF4686"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15742">
        <property type="entry name" value="DUF4686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="651"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553415.1"/>
        </source>
    </evidence>
    <sequence length="1175" mass="136602" checksum="54942493F183532A" modified="2020-12-02" version="1">MSSLVILESDKGELKDIDDRLIQDGYSTSIPVEHKLRYXWRQFGRAETSLKSSLESLEQLRKQHAEEMIEVENYVTHIRQLSDEREDLTKDLETENEQLKAEMEQMKVEREAGAVVSEEVCDMLRDSGMKEISKETNTVKNQVGHLLKERATNLERIHRLEREVEFSKKEDSSSQSNKKVMEIVEQERREMEEEMSRLRETTKQVKMEMKKMHEKELEDLTRENKELKKKLDQSQDQFNKDMAVMLKKFEDDKMRLVEEKEEEQEKTTHQLSKADRVMKEMEEIKVKMKDIEQEKISLHSTVKSLEEEIRKEKEQLNGNKATQDTTIKKLRSELSXTKQKLLETEAKMKTVQEERNTLESRLKMVTTDLNNLKQRENQLNTEKESLLTEGKTNVQKLQIQVTTLTDEIKSSRERLKTSDDTIARQTKQVENLTVQLGEAERMLREKEEDMEDLDKSTKNEINNLKARLAQTSEEASDLREELAETKKHYETIIQQSKEEASSFREKLNEESGKNKNVESDRDILKSQITELRKDLEASLAASVSREKETMNQIAVLQDDKDKLARELAGYISREKDMTKCMEELRLXMQSFEGEKTSLQTVISSQEKQVADLIIKLEKSDQKCAVMEHQLSSEQSKTAELSTRYHYTSESSSSARQEVDSLKEEVKALTAQLLRQHDATMDSRSKYEKLIMELKSEMEREREKFSTERHSLASQLEVAMRESKDLSTLLRAREEELNLLRNELSSASTTGTKASTALEFESKLRGTLETRANHLESELSKAWGQIKELTEKASGLEATKRHLEIELDRRSQQLXQSESTLHKRQAEHTAVMVAKDTAQQQAEEAETKLAALRREYEILVSQLEKTQVDLQTASDQLMELHLKHQENDALRGHLEEEQVNKNIQNQTVKELEHQNDVLHERNNQLQQSLKQQENTIAEMKEKMRKNNDKQKQSESESKSLSERMNEALQENEMLKQELIGAADRIDNLKRKNDERKTKTQAKVQALRNQFARDKRNLEEKVMSLENALGLVRERALKEEEWEGAANATLKTLQQEKRQLLTNLMDSEEVIREYQRTSRESEARLAMLNKENDELQNKVNELTKDKISLSRELTKTRSTSPFSSTXTKGPIDSQVLMNALARLHQSDPRDSFISSPSXDIYSPENRSPERTMNMTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM62</accession>
    <name>A0A6P8HM62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116292880</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556088.1">
        <property type="nucleotide sequence ID" value="XM_031700228.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292880"/>
    <dbReference type="InParanoid" id="A0A6P8HM62"/>
    <dbReference type="OrthoDB" id="10066605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578:SF6">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="8">
        <location>
            <begin position="8"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556088.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34873" checksum="4BA2DBF304A83011" modified="2020-12-02" version="1">MQTSTANPNADPEPGPNWYVAKRIWGQAWQVHWIGLGXAFALIAVHSLVAMLMADKRKAFTRRLLFYAINSLLVIFGSVRALLLLTDPYGSSEHGFNIELWLTRVLFGLXFPCLTSAFCLVHVAFLEVSKLQLGSKKXHSLPFVFSIIVLHFXVVLVSXLTVALEADKTELLIVCQSFFIVWGFINSIAFLYSGGKVILTSRRAKKQLNQINLQETSNDGNAGRKKSTVKVAKITXXTAFLGFVCCGLQIYSMVGXYGLYSRVXNPAPWPWYGFQTCFRMMELXMGCTLAYTVIQPLENRRSVLQRLNLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNH4</accession>
    <name>A0A6P8HNH4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC116294467</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC116294467</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557922.1">
        <property type="nucleotide sequence ID" value="XM_031702062.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557923.1">
        <property type="nucleotide sequence ID" value="XM_031702063.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557924.1">
        <property type="nucleotide sequence ID" value="XM_031702064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294467"/>
    <dbReference type="KEGG" id="aten:116294467"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031557924.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="67114" checksum="A21B6061EC7857F9" modified="2020-12-02" version="1">MERNLEIRRPVHQDHHGLSTVSKIFFGVDIFQVVIVVTFQSVMITYGNYNAFNSPENPGMGPGRRIYMCVYMGVVVYTCFLCLFAVKQQNILEIFAFLLQNFGFVTYGLIQVYHVGYKELPIPGSNATMQHNNVLRNVAMTNSIALFFLNGVFIFLSWKLYTEFGWKIYKRVRFNMSLRSIYHFYQLLSCLLKMEIMYWWMYAICNSFVLLRDTGTVMYYVNLVFIPLSVFYAGLGYIATQREIKILMSLFIIWTIGGAGYFLYKLYGFVSDTCNGCQEFHKTGKDIHDEAMLHFVYLGSLNLILLLAILGVSSKVFANFGKGLEEHFKPQQEGRPRSETDLYLRRVSHYIEESVVSVTSYESEYDELNESMRLGYHEGMSTSAAFLLESDXHSLASSMPNLAEASSTKAKTLXLEKGKTCTENTLRTFEKNVLPRKGKLLAAIDEDVDFQANNTNGLHKPGNSSIIEVKRKDPNGILNTKGDRCKPSADEGSDEKNEKLRISSNNDNALDNGKVFNDLHDAERDSGCVDCNGYDLKSTILKTRKCAITSDERDVEVISTNKVDGVRDDREQDKHNGSIKRKISTLNIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNN4</accession>
    <name>A0A6P8HNN4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">SID1 transmembrane family member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC116293922</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557284.1">
        <property type="nucleotide sequence ID" value="XM_031701424.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557285.1">
        <property type="nucleotide sequence ID" value="XM_031701425.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557286.1">
        <property type="nucleotide sequence ID" value="XM_031701426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293922"/>
    <dbReference type="KEGG" id="aten:116293922"/>
    <dbReference type="OrthoDB" id="416618at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051033">
        <property type="term" value="F:RNA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025958">
        <property type="entry name" value="SID1_TM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185:SF14">
        <property type="entry name" value="CHOLESTEROL UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMEBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031557284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557286.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56968" checksum="C91E3B31DD861CFB" modified="2020-12-02" version="1">MPKKAPSTEDEDENESLSPLVEARSLTSGSRFKYGSVQKELNETPEVXDQNREXREHAYDSESLPEPSTEHIEKDYDMLHDLEHEKDIYRLRTFVTVADMSKKNRKQLKKKYKLYHWNLIVISVFYTLTVLQLVITYQNVLRSSGDEDICYYNFLCAHPAGLLSAFNNVYSNIGYILLGILFFFIVLRRDRLHKQAIASKDIQEKSCGIPKHYELFYAMAMALVMEGVLSACYHVCPNNSNFQFDTSFMYIIACLGMVKVYQTRHPDIVSSAHXVYVLFAXIILIAVVGVLFSSTLFWSVFCVIHITISLYLSSQLYYMGRLKFESGMLTRLLFFLRYDCCACPAYRDRMLLLIIANAVNWMFAICGVVYEPKDFATYMLAILIVNGLLYVGFYVIMKIRNKEHILVLPCVVSVLSLVCWILALIFFFQELTSWQKSPAKSREGNRECRLLGFYDDHDIWHLLSASALFFSFLAVLTIDDDLEDVPRKRIPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP90</accession>
    <name>A0A6P8HP90_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293568</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556868.1">
        <property type="nucleotide sequence ID" value="XM_031701008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HP90"/>
    <dbReference type="GeneID" id="116293568"/>
    <dbReference type="KEGG" id="aten:116293568"/>
    <dbReference type="InParanoid" id="A0A6P8HP90"/>
    <dbReference type="OrthoDB" id="10345231at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028029170" evidence="2">
        <location>
            <begin position="28"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556868.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28828" checksum="FA1EB96AD04469E2" modified="2020-12-02" version="1">MKMVNLRLVLLLASVSFLGSHMAQANASREEDEGSSGTNTILQTNSEEDLSGDESGAVELELPELPSEENAPEIGLNDSSYQSRSKRSEPVFKCHCWIGWRYYIKYKYVDFGEIGLYPRREACKHECSTKCAPWLEKKELLCQKIGGRYDSRKQRSVGCFSQFGYPNSQENIWEFNNLPFELCCQSTGINCAALYGPRFYYNSCLGLCVKNTKSCCPPWLINNRPSTPHCCDNHKFSVCKKPKCGVHSVPCPNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRC7</accession>
    <name>A0A6P8HRC7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555232.1">
        <property type="nucleotide sequence ID" value="XM_031699372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRC7"/>
    <dbReference type="GeneID" id="116292120"/>
    <dbReference type="KEGG" id="aten:116292120"/>
    <dbReference type="InParanoid" id="A0A6P8HRC7"/>
    <dbReference type="OrthoDB" id="5987529at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555232.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49322" checksum="6B0A797CB8EBB815" modified="2020-12-02" version="1">MHVCYCSQVRTFVHILEKCNQDWFSVLSVLENLFLELPKTLPNIKEVFLRSDNAGCYHNAALITSIHTIAKKQGLILKNYSFSEANSGKDVCDRNIAPLKAHINRYLNEGQDITSAEHLKEAIDSYGGLKGCQAAIIELDTNIQSATKPFKLKGISKLKQFEYNIGGEMTVWQAWNIGKGMKISKTGSPQGETGVIVTRPFLEPKVTSGILKKIIVEPSSCPAAKNEPNVPDVKDKEPVKFYCPEEVCIKAYSCSRYLKQHLDIGKHEFKLHEESQYDQIRRKWAQKCTSLKPPNPSCPPMVSSASTSEEVHVPDLVTGWALKKSKQCNRFPLHVKSYLVGQFLIGEDTGRKVTPAETSTRMRSMRDSNGKRVFDKEDWLTVQQITSYFSRLVAMKKLGQLPPAPLTEEEEEEVEVAVRTTERYNLRERVLRKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSW0</accession>
    <name>A0A6P8HSW0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558521.1">
        <property type="nucleotide sequence ID" value="XM_031702661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSW0"/>
    <dbReference type="GeneID" id="116294963"/>
    <dbReference type="KEGG" id="aten:116294963"/>
    <dbReference type="InParanoid" id="A0A6P8HSW0"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028370749" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="26"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031558521.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="37147" checksum="E5D429C9AF2FFF01" modified="2020-12-02" version="1">MLHLKNLSIFLLSLFLFLLNNECECTVEPHKDHLYKHEHFTGSNEHDVRYDHEAFLGPDAEKFEDFPPEESKRKLKIIVIARIDTDKDGFVSEGELEAWIEKQRKAFMYEAVEKNIKKEDKDGDGKISWDEYKLEYFGEWDDTNLPKDHNLRRQIHKADHKFKMADEDKDGKMDSDEYVNFQHPEETKHMEELAIDEILEDVDQDGDGFITVEEFIGQYGDKENAPAWVERERKEFARQFDKDKDGKLNREEVRDWVLPERGESLDETKHLIDGSDDNADGRLSVDEILVHWDLFVGSKATDHGETLRKMKHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT43</accession>
    <name>A0A6P8HT43_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Globin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14 15 16 17 18" type="primary">LOC116295774</name>
    </gene>
    <organism evidence="9 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559553.1">
        <property type="nucleotide sequence ID" value="XM_031703693.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559554.1">
        <property type="nucleotide sequence ID" value="XM_031703694.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559555.1">
        <property type="nucleotide sequence ID" value="XM_031703695.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559556.1">
        <property type="nucleotide sequence ID" value="XM_031703696.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559557.1">
        <property type="nucleotide sequence ID" value="XM_031703697.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559558.1">
        <property type="nucleotide sequence ID" value="XM_031703698.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559559.1">
        <property type="nucleotide sequence ID" value="XM_031703699.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559560.1">
        <property type="nucleotide sequence ID" value="XM_031703700.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559561.1">
        <property type="nucleotide sequence ID" value="XM_031703701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT43"/>
    <dbReference type="GeneID" id="116295774"/>
    <dbReference type="KEGG" id="aten:116295774"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013314">
        <property type="entry name" value="Globin_lamprey/hagfish"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01906">
        <property type="entry name" value="FISHGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031559554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031559556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031559558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031559559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031559560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031559561.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19332" checksum="33181EF2D1E54AC6" modified="2020-12-02" version="1">MGCASSIDSNVRKEFVSIPLSTTQKYLVRETWETIDAHKNSVGKKTFLRFFEINPDFQKLFPEFVNLKREELERANALHGHAKRVMKAVENAVTAMDDTESFAAYLEGLGQRHVARALKPSYLDAMQVALMDTLQDLLQSQWTQETSEAWNILFRFIADTMKRGLQSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU71</accession>
    <name>A0A6P8HU71_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116295162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558778.1">
        <property type="nucleotide sequence ID" value="XM_031702918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU71"/>
    <dbReference type="FunCoup" id="A0A6P8HU71">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="GeneID" id="116295162"/>
    <dbReference type="KEGG" id="aten:116295162"/>
    <dbReference type="InParanoid" id="A0A6P8HU71"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050260">
        <property type="entry name" value="FAD-bd_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43429:SF2">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="281"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558778.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53722" checksum="F3F0EDCB48BCA40F" modified="2020-12-02" version="1">HLNLLCPDKKVTLITATDLVKAVVNLNQYGRYIEDFDVEEKSVDSFSSGLSNLTVVKGKVKDFNPEDHYVTTSDGRVYEYEKLLISTGGSPRLIDDSNPHVIGIRDTHSVQYFKTRLADARRVAVIGNGGIAMELVFELTGHEVLWAIKHDSIGNHYFDKGAASFLLSHLESTNTPRPKEPVIKRMKYGRIVGKELSPASLEDKSLSEGGVIGGALGPDWSQGLSLHSDSTEDSYRNIHIEYKCEVEKILTPQNLLDQNFEETPFPRNKCLYEESTQWPVYVKLTNGKIYGCDVVVSATGVTTNTAPFISNAPFDIATDGGIKVDDNMRSSIPDVYAAGDVCTTSWEPSKLWFQMRLWTQARPMGAFAAHCMSDNLKGQQVPLDFCFELFTHVTKFFGFKVVLLGKYNAQGLGNDYQLLFRCTKGVEFVKVVMQNGRMVGAVLIGETGLEETFENLILNEIDLSGFEDSLLDSRVDIEDFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU92</accession>
    <name>A0A6P8HU92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC116292961</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116292961</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556183.1">
        <property type="nucleotide sequence ID" value="XM_031700323.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556192.1">
        <property type="nucleotide sequence ID" value="XM_031700332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU92"/>
    <dbReference type="GeneID" id="116292961"/>
    <dbReference type="KEGG" id="aten:116292961"/>
    <dbReference type="OrthoDB" id="6116165at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF31">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653092" evidence="4">
        <location>
            <begin position="24"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="169"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="286"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031556183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556192.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52606" checksum="5BB029EA78F2E495" modified="2020-12-02" version="1">MKHLPVFLTTFAYILLLPKEIDGMTACPSRTISVPPDDLEVTSEGYADGDEYALGSNCTLTITTDPGKVFKVTLNDLEIQPDPDALYEKFPVKLFKCKDNMVVIDFGSEKFERCGRLYQDEPETFVSTGNTMSIHFLTQKEKSFNRRHIRGFSLSYETQVAQVDGESICPGRHIKKKRSGTLFSPGFSSNYGNDQDCQVVIPIPDNFQMNVWFSDFSLQNSPTCQNDWLTIKDEHGGQRMCAGGVNRLPPFKELKASLAKFHFRSDSSVDRKGFRLHYNMTRLRDGHCMCTLGKSFICMMNFNKKVRRLWHRIKFSIKTTQLNGLIMFSKGTLRDYMYLGIRDGTIFYRSDLGTGSSLVVANDAKVNDDVWHKVEIRRRKRSLSITVDDGRAEDTSKTRGNFNKIDLPESVGFFLGTPPELNILPNFVGCIQDFTVDGREPLSNAYVSKPEYPSYGMEYMSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW81</accession>
    <name>A0A6P8HW81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">RWD domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116295817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559626.1">
        <property type="nucleotide sequence ID" value="XM_031703766.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559627.1">
        <property type="nucleotide sequence ID" value="XM_031703767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW81"/>
    <dbReference type="GeneID" id="116295817"/>
    <dbReference type="KEGG" id="aten:116295817"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23816">
        <property type="entry name" value="RWD_RWDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559627.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27572" checksum="D40FAC896AAD1267" modified="2020-12-02" version="1">MTDYKEEQHNELEALESIYPEEFSIISNEDPICFKMCIKAFNEKTEDFPEIVAKVDIQFTYVENYPDAIPLIEVSSNEILTDENVQELEELMLKEAEENLGMVMVFTLVSSAQEKLQEFVDNIKKGMEEEKRRREKEEEEREKKKFTGTPVTKENFLEWREKFNAEMSEMKKKTRNVLLIPKSKITGRELFEQDEKMILSDAAFIDSTDVDVEVDESLFQDIDDLELDDEEFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWJ8</accession>
    <name>A0A6P8HWJ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-adducin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560769.1">
        <property type="nucleotide sequence ID" value="XM_031704909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWJ8"/>
    <dbReference type="FunCoup" id="A0A6P8HWJ8">
        <property type="interactions" value="2268"/>
    </dbReference>
    <dbReference type="GeneID" id="116296815"/>
    <dbReference type="KEGG" id="aten:116296815"/>
    <dbReference type="InParanoid" id="A0A6P8HWJ8"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000013">
        <property type="entry name" value="Class II aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005451">
        <property type="entry name" value="PRK07044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="120"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560769.1"/>
        </source>
    </evidence>
    <sequence length="629" mass="70483" checksum="F07C314D406A9BA2" modified="2020-12-02" version="1">MSASKAGRAITDMKARRLSAPARSKAVKRPEDIVRDVRGLKLRQRVSLVLNDKVLREELEDIVENFVHNGPKHTENIRAYQDFLVPTYGGNAGGSVVTPIADIRGSDTLNYSKQERLLRCKVASVYRLADLFGWSHGIYGHITARTSNEEEHYLLNPFGLLYSEVTASSLVKVDIEGNLIDGGSTSLGISKAGLVLHSAIHGARKDIKCVIHLHQTDCTAVSATEFGLLPLSIEGSVLGEVTYHNYEGILMDDEEKQSIVKDLGDTSKVLILRNHGIVCCGETVEEAFDLAFWAVKACEQQVRAMAAGVDNLLKIDEQARKHDVNVHSNDSINQSKTKWKTGELQFEAYMRMLDSRGYRTGHLYKNPDVFIGDKPSAREVTSPATTTSTRAHLFFTPEIDKQPSRSHSTGRANTYRNRVKWLNTPVKSTEYKKESDIPEDVDETVIIKDQKPEKVDKDIIKTEKKEDDEIVMHTTNVIVESSPDAWPEEEKGVADAETPEGVTHKREIKETTVVVSRLVDKDGEVTQETQVTENKKVFVNGEEVKDEVTHLKTPEEEEEEKEEEKKEEDKEEHEKKEEDGEGGATAESPEPGSPSKTKVKKKKSFKDALKKKFSKRGKDDHHEKTEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXG5</accession>
    <name>A0A6P8HXG5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557355.1">
        <property type="nucleotide sequence ID" value="XM_031701495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXG5"/>
    <dbReference type="FunCoup" id="A0A6P8HXG5">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="GeneID" id="116293989"/>
    <dbReference type="KEGG" id="aten:116293989"/>
    <dbReference type="InParanoid" id="A0A6P8HXG5"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557355.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="58442" checksum="554806AD93E86925" modified="2020-12-02" version="1">MAKQSDLHEFDNVFRHVKSFGRYQVIGYLSINLLIFSLSSQWGGIVFALSSPGFHCANTTGNTTCEPNVCCDECTSYVFDGTFTSSVTKWNLICDRAYLGATIQSCFFVGMLIGSFVTGMVSDAWGRKECIFFCNALFIVSNTASAFVDCISFFAFLRFTVGFSMTGVMLTSYIYGVELAGPKKRTAAGIITYFYWSGSSVVFTLIAYLIRDWRYLLTATCLPNILLFPFWRLMPESPRWLIANNKLDEAENVLMKFGGKRGRPIDSDQLRKLIENIRIDQEEKENHAERHTPLDLLRTPKMRKWTLIMGFQWFSTALESFGILIFFTQLAGDPYLNYLILAIATVVRVPFTWVVFLKFGRRISYGGSVIFVGVVMLATYAVKDIPKATTAFAIIGFVLLDHIWSGVYLITSEIFPTVLRNTGQGTGSTIARIGAIIAPYVAMLSQIPSLGVIVPIVIFGALALIAGVMMNWIPETLYAPMHQTIEEAEAAKEDFGIPCCGNILDEDERMDEDKQLTRICLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYD9</accession>
    <name>A0A6P8HYD9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal multifunctional enzyme type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116294223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557637.1">
        <property type="nucleotide sequence ID" value="XM_031701777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYD9"/>
    <dbReference type="FunCoup" id="A0A6P8HYD9">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="GeneID" id="116294223"/>
    <dbReference type="KEGG" id="aten:116294223"/>
    <dbReference type="InParanoid" id="A0A6P8HYD9"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557637.1"/>
        </source>
    </evidence>
    <sequence length="724" mass="78710" checksum="9529284205E31096" modified="2020-12-02" version="1">MAAPIRFDGRVVLVTGAGGGLGKQYALAFAARGASVVVNDLGGDPKGEGKSSRAADLVVEEIRSKGGKAVADYNSVEDGEKVVQTALDAFGRIDIVINNAGILRDKSFARISDLDWDLIQRVHLRGSFLVTRAAWPHMKKQKFGRIIMTTSTSGLFGNFGQANYSAAKMGLVGLSNTLSLEGTKYNIYCNAIAPIAGSRLTQGLMTPEMLEELKPEYIVPLVMYLCSENCEENGAVFQSAAGWHSKLRWQRSKGKLLHRKGIEVTPEMIRDNWDNITDWSGAEYPSPQDAQTVLMQIIEDKNSGSEDTSGDSKEFSFSYTHRDIILYALGVGVSAKDDYSHLKFLYEGHEDFSVLPTFGVITSQGGMSEIFAKGELGGIKFDLSRLLHGEQYIELFKPFPTSGTVTTKSEVVDVLDKGKGALVLLNVTTFDEEGEAICLNQSAIYLGGSGGFGGKRNSDKAKPLVNAPSRNPDASIQEKTGVTQAALYRLSGDYNPLHVDPAFAQMGGFSVPILHGLCSFGIACRHVLKQYANDDVTKFSAMKARFAKPVVPGQTIQTDMWRENNRIHIQCKVVENGNVVLSGGYVDLVNITQEVPDVNSLISKPSSSGLKSEALFQELKKRISSHPELVKKVKGIFQWNVTKNGKTLGQWVIDLKTGSGAVIEGISNSLKPDCTITVSDEDLIGLAAGKLNAQQLFMKGKLKVTGNIMLTVNLDKLFKEHSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYP9</accession>
    <name>A0A6P8HYP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116296622</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116296622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560528.1">
        <property type="nucleotide sequence ID" value="XM_031704668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYP9"/>
    <dbReference type="GeneID" id="116296622"/>
    <dbReference type="KEGG" id="aten:116296622"/>
    <dbReference type="InParanoid" id="A0A6P8HYP9"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031560528.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12502" checksum="4486058DCD1D9FFC" modified="2020-12-02" version="1">MPAPGPATAAQFRVINMGGNVVALNSIAYPQFFLGIDNGRLMGKTFDTYCHFYIHETPDHYVSLESCMLPGQHIGVDHHTAMTPPASTPKNDQAFFEVKLLVCRWPGHETSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ48</accession>
    <name>A0A6P8HZ48_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein AATF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116296653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560566.1">
        <property type="nucleotide sequence ID" value="XM_031704706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ48"/>
    <dbReference type="FunCoup" id="A0A6P8HZ48">
        <property type="interactions" value="2727"/>
    </dbReference>
    <dbReference type="GeneID" id="116296653"/>
    <dbReference type="KEGG" id="aten:116296653"/>
    <dbReference type="InParanoid" id="A0A6P8HZ48"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="4">
        <location>
            <begin position="180"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="3">
        <location>
            <begin position="433"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031560566.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="61391" checksum="5C04604A02AC594C" modified="2020-12-02" version="1">MASIAEQIRSLSRPEPTHFDPEEDDFDITRAKLVSKDDNEELDGEKLDSSSLRKKNIALLADEDSKYHGRPVSRGEIARMRGDFQDSDESLEDDEEDDSDEREEIESDDDDGIKEKENREESNENEKDVEDDDDDEDDSEVDCDDSDEDDDDVENGRGLNDEEEEGRGIDSFSSSRREDEIEKGIAVKQQLSLWDSILEYRIRIQKAMMLANKLPQSDNINVFTSSNDINLKSVKDKERKSLMDFLYKLLKVQEKLLEGNPETRSILHPGNKNGKQDSEDDEEIPSDSEGEDEKKKSDEEEEESENIPSLKLPAKRKRDLTQEELSECITKRHAAFQSYRDSVISKWSEKTRLASGKLSSKSFSAFDKSALTQIKQILSDKPRLIRRTQLKRSSYRVLGKTDKDASTGTETEEQANAHLKDYDSEIFDDDDFYHQLLRELIERRTTTNTDDPIEMGRQWLELQKLRRKIKKKIDTKASKGRKLRYNVHSKLEGYMPPIETGTMPDSSRNELFSSLFGQSKTQTEIFDLDVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ69</accession>
    <name>A0A6P8HZ69_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-sarcoglycan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116297569</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <location evidence="3">Sarcolemma</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561679.1">
        <property type="nucleotide sequence ID" value="XM_031705819.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HZ69">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="GeneID" id="116297569"/>
    <dbReference type="KEGG" id="aten:116297569"/>
    <dbReference type="InParanoid" id="A0A6P8HZ69"/>
    <dbReference type="OrthoDB" id="5843723at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027659">
        <property type="entry name" value="Sgcb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21142:SF2">
        <property type="entry name" value="BETA-SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21142">
        <property type="entry name" value="SARCOGLYCANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031561679.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33369" checksum="03616220D1357578" modified="2020-12-02" version="1">MSSNRQGRRXNLVDKDKDDDGYDNIFDAGKVKVSERSLHRTGIRGRKIWLFLTVLIILLILCIXNLVILAVIYGVIRIDKDGVESLSFFEDGMIRWTKPSDLETVTVYKNEIGGFKDRDLNIETTQNEIVLHGGPSTLSSQVHISDGNTTIIGKKGLKFXDPFVEKEIVSFDGSSSQFLQQSVHGNDIGINTVLSHRIVSNEYENLTLNSDKDIKIRGNEGIKMDGKSLSFNAEKDITITSTVGKGIIFDSPEIALHLKSNISPTIDKYKLCICKDSFKVFGVKQASKTSSCNTEKKVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0I0</accession>
    <name>A0A6P8I0I0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Switch-associated protein 70-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561233.1">
        <property type="nucleotide sequence ID" value="XM_031705373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0I0"/>
    <dbReference type="GeneID" id="116297193"/>
    <dbReference type="KEGG" id="aten:116297193"/>
    <dbReference type="InParanoid" id="A0A6P8I0I0"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13288">
        <property type="entry name" value="PH_Ses"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF53">
        <property type="entry name" value="INOSITOL PHOSPHATASE INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561233.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39403" checksum="0933E6EA622F6C30" modified="2020-12-02" version="1">MKVGVFFPQRMKLNERSLAQFSISSAPIDKEGYLNKKGELNRGYQRRWFVLKGNLLYYFERKGDKEAIGVVILENCHVELAESEDQLYAFQISYGGAGSRTYVLGADSSQEMESWMKAVTNASYLYLKMMVEDLEKRLQDLTTSQNEMVNDSLSDSERFLDSTESADAEVKVNRHSASQIVENRLSISKPMPASRTPDSFGKFEPTVGTLIDFDSLPEQDTEFYSMGKSPEDLLPLNFNEFQHLEALHARELDSQREKSQVSQDDSLLGQRLAAGNIRAPRSKSERRRNLKPDISDVSSYRSITQTFTDEACGLTDQGSVFKRLHEKYGASIWVKVKECGKKDAFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1D0</accession>
    <name>A0A6P8I1D0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116298146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562384.1">
        <property type="nucleotide sequence ID" value="XM_031706524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1D0"/>
    <dbReference type="GeneID" id="116298146"/>
    <dbReference type="KEGG" id="aten:116298146"/>
    <dbReference type="InParanoid" id="A0A6P8I1D0"/>
    <dbReference type="OrthoDB" id="5965679at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562384.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="37250" checksum="B55AC8EE4BE2AAE4" modified="2020-12-02" version="1">MRAQCDKSRVEQVRNKVAKLKRNLLIAENKLREARESLLASSDERLKKTLGFRWRYERQVKSRSLVTEVIPVLAPPCRNIAVQRFHDRLGFRNIAYASTKPSAGDRCSMHHSVVTDRCKTIVKKELSNSSEPSNKPRSIANSGYHLRRMTSKVCAARNKSSNFQIKFKTLRERLHYLEAKILKTKSRVEIADSLIKVLKERLSFLGERVKAHEVNRRYRRESMQKISDLENRITIALNKAIEVENLEGVLETRVLEIEDSIEVYNMKIQRAQDVLHRLNQGKIPANTCTVTMVFRRISLSSQFSFKPPLPVLLQATYCEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1X6</accession>
    <name>A0A6P8I1X6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable G-protein coupled receptor No18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116295255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558887.1">
        <property type="nucleotide sequence ID" value="XM_031703027.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aten:116295255"/>
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    <dbReference type="OrthoDB" id="5975661at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031558887.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38687" checksum="23764AAF0C4E13B3" modified="2020-12-02" version="1">MENMAELVVMTIIMISIALAAIGGNLLVIVAVLWNKRIRTVPNFLFINLAVADFFQGLVSIPLRLTEQLNHSDIKPLVPCLVVIPLTILFYSASNINLTVISLDRFVALYKPMHYKNIVTPCKVITTVLISWIIALVLALLPIMGWGPKNDIDLIDICLFSTTLTKEYLFMLFTVINFVVLVILGITNIYILRTARKQIRRIHVVTNVRVLDQNTDSMSTMNQTAETTGPTGSKRSGISSFASFRRRAHANATRFSGRRERKATKVVLIIVGLFIILTVPITVIDILGVFDVDVDVPLLLIKITACMAYSNACLNVFIYAGYNKDMRDTLTMMYLRLKCFLRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I275</accession>
    <name>A0A6P8I275_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone deacetylase complex subunit SAP130-A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116295312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP130 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558955.1">
        <property type="nucleotide sequence ID" value="XM_031703095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I275"/>
    <dbReference type="FunCoup" id="A0A6P8I275">
        <property type="interactions" value="2229"/>
    </dbReference>
    <dbReference type="GeneID" id="116295312"/>
    <dbReference type="KEGG" id="aten:116295312"/>
    <dbReference type="InParanoid" id="A0A6P8I275"/>
    <dbReference type="OrthoDB" id="10048604at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024137">
        <property type="entry name" value="His_deAcase_cplx_SAP130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031963">
        <property type="entry name" value="SAP130_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13497">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13497:SF3">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16014">
        <property type="entry name" value="SAP130_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP130 C-terminal" evidence="8">
        <location>
            <begin position="602"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558955.1"/>
        </source>
    </evidence>
    <sequence length="875" mass="94488" checksum="86E6943E8A686765" modified="2020-12-02" version="1">MSFQGDDRSDRETVNTPSSVVKNTSTDNDKTGLEKTKVLPNQSTAQTNEGPSQPQQQQQRQSMDVPNMKTSKPQPNRPIAPAAASNVMPIGPPLNTGYMHMPAFGYPQMMNPHMIGRPMQLQAPQQYSHVPFGASSAAISASAHPKGISPSLRGASLPTAAKLSGMTSHLQGQTLTLQSKTHPAVSTPTTLSRPSSPAMPIPSTSSVPSFQQQSTEHKPVEVRSPMMPDHPRRTSSPHCPSSTVQNSSAVITSVKTTLHTPSVPSHKPGQPIMLPHFVQDHSSLTASSYPPPAVSSSMQPGGNGTVVSMAISQHLPKPIQSVSVTMAPTMDKMYASHMSMIPGRPGIPQPEAIASPDISRLSGKQSGPASPVTVPQHSVVSTVPSSAHVIAASAAMQPSTVMDARMERPHPSVTITNTMLTNQMGMYPRYVFPETTGFPFSHSGFPPPIIRPLHTATTPVSSGMHILDPQGYMAVANNALRTSVAMMDSTGGQSIYGMPVPMQQPSNLQMPISSSNPNATSPRPSILRKRPSEGIRKPAVVPYNDGTSATPSDPNVSPRSDSTLSAPQSGQSSPKPPSDSGSQPSEPPQQQQQPPVVMPIPTTSKVEPPVTVQNVPEPPVQIKKEQNEIADVTTTGTTVTSSMAVATTSSSTAEKPAAVSVALPDGASPRKKPRKQNVVVTEDKYGSSVPLEEGSSDEEEKKPKPQPEDTVMDDDLKFILLKRPKISIYGGYKVNTKAAHNHFLRYSDIKIKEERKPTLQDIANQKNILHRVSGWRIHHVAAQMDDLNSIEQEVLSKLFEFRENLPKPRPGQKSKYHDELVMLDELVQGNIQRSQLVTEQLADIRKVMVKALDHRPRCVEVLQKYINKRNPKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2Q5</accession>
    <name>A0A6P8I2Q5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="20 21">A disintegrin and metalloproteinase with thrombospondin motifs 18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC116295497</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20 21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559182.1">
        <property type="nucleotide sequence ID" value="XM_031703322.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559183.1">
        <property type="nucleotide sequence ID" value="XM_031703323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2Q5"/>
    <dbReference type="GeneID" id="116295497"/>
    <dbReference type="KEGG" id="aten:116295497"/>
    <dbReference type="OrthoDB" id="5988823at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653129" evidence="17">
        <location>
            <begin position="25"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="18">
        <location>
            <begin position="207"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 16">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15 16">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="509"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031559182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031559183.1"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118418" checksum="D9F6E6B57564F6A3" modified="2020-12-02" version="1">MFIQPRVLLSWCWIFSVCVCQTEGKTKPDLHQHMTQRELQKFFGVNSHQEVPDYDIAHSYSVDSPRAKRSSESSRLYKLKAFGSSMDLNLELDPSVKSPHFVVHSYEEDGSRVDSTIDDVKLYTGHVEGHPGSRVALKENNGLSGLISLNDKAFFVTPLTERLARAYGYNGDGQPHLVYRQPKDKAITDFQDLLNDEHSQSSEAGFKVLEMTLVADEFLINVYEKETAEHLLMIAHIARSLYLDHTIGPIKINIVVVGVVLKKDGLGYDSSASSLTRLGALGDWCQKNLPTLDTDPGHPDTVVLISKNIAGRALSSSTCFYTFGKAAVGDIGPATGAIVAHETAHTFGVLHDGEMQNPLCPGHKYIMSYASASGPDAYKWSVCSKEKIQAFLRSSDSSCLDDEPDRSVESHYAVKYINKLPGDALDRDIQCKMMFNTRYFACPMKSNECSSLWCSHSKSGPYCEHMRIPPVDGTACGPRHWCIKGICEDNGSPIIDGMWSGWSATYTRCSKECGIGLQWRTRTCTNPSPKNGGKDCPGSAEGRWKLCNTQDCPQGTMDYRLEQCKAIDPKFDGVHYYDKEPCILKCKIGHYIWNKGVVKDGTRCYNDHTDKSVCIKGRCRVAACDESLDIGIKYDRCHVCDGDSSSCGKLIGLFDAPCIGHGPDHECTVISVPVGATNVNVEKKLADGNAILAIRDGNGQIITPHFPSPTTVVDFKGTRVYYYYQEPRDRVFIPGPTTIALSIVNIPLYNKPNSGVEYSMFLKNMTTVVLPSDAEWKTAEWSSCTRTCAGGTQVRAVECVRKDDKSHLGTYVCESNARMPAAVQVCNQQACPQSWYKSNWSPCSKTCGKGLQTREIICRQEISKQKYKTLPDSSCSGEKPTGDLRKDCNKVGCPLEWVPTPWSKCSTTCGVGAMTRKLTCMRRTSEGDVIQLHHLMCNDIPRLKTPTVKPCEQLPPCPTVSPTISVTPSIYQPLGCYKDDKPNAMPNLVINLRDSIDWSNLNKTIDACANYVHKYYPEYKVFGVQFYGECWTGLGAENTYMKYGAAENCYKGVGAKHSIYVYKLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I316</accession>
    <name>A0A6P8I316_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melanocyte-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116295521</name>
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</entry>
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</entry>
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    <accession>A0A6P8I3Q6</accession>
    <name>A0A6P8I3Q6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562126.1">
        <property type="nucleotide sequence ID" value="XM_031706266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3Q6"/>
    <dbReference type="KEGG" id="aten:116297910"/>
    <dbReference type="InParanoid" id="A0A6P8I3Q6"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="431"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562126.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="72906" checksum="DFA4F04B49BC5D2E" modified="2020-12-02" version="1">MAKQVSPYGSWVSPISSDLVIKESLSLREVRLDPLDKGTVYWSELHPEEAGRTIICKVKDDDKNIEVLTPQDFNCRTLVHEMGGGTFIVYNKKIYFSNFGDQRLYSQESKPGCTPVPITPEGKQWRYADADVALNGRVLVCVREDHDVLKEGAEEALNTIVSIDLETQKQNVLVSGCNFYASPRVSHSGMLAWFQWNHPNMPWDDTELWVGQLNEAGDGFVEGTKKKVSGGVGISISSPRWSNDGKLLFISDKNNWWNLYKLEDDGTETNLCPLEKELGIPHWIFGMNAYACDPRPGNKDVLVTFGENLSLLKPNGELLNIETGGTQHSQVVTDGHSAYLITRSATRFPALIRVNLESKKVTVLKESFTVHVDPEYLSVPREVTYPTTDDKVSHGFFYPPKNKDFNAPEGSLPPLLVKVHGGPTSACGPALNLEIQFFTSRGIAVLDVNYRGSTTYGRKYREELKGNWGIVDMDDCCNGALYLANTTKEVDVNKLAIDGGSAGGYTTLSVLTFRDVFKAGASFYGISDVEALAKDTHKFESRYIDTLIGPYPEAKDVYKERSPIHYVEKLNCPIALFQGDEDKIVPPNQAEMMFNAVKNKGLPVAYKLYKGEQHGFRKAENIKSTLEGELYFFSKVFGFSAPGLTVELEIHNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4C4</accession>
    <name>A0A6P8I4C4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein LOC116298966 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116298966</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563419.1">
        <property type="nucleotide sequence ID" value="XM_031707559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298966"/>
    <dbReference type="KEGG" id="aten:116298966"/>
    <dbReference type="InParanoid" id="A0A6P8I4C4"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027626472" evidence="12">
        <location>
            <begin position="24"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="10">
        <location>
            <begin position="767"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="10">
        <location>
            <begin position="810"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="10">
        <location>
            <begin position="853"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="10">
        <location>
            <begin position="897"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="986"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="1050"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="1161"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031563419.1"/>
        </source>
    </evidence>
    <sequence length="1409" mass="157700" checksum="856C8420E96BC0E0" modified="2020-12-02" version="1">MDSRVSTARFVIVLTIFLIKGQAIGLDGVHVFASHGFHEIQESISSRIDPFSNEFLQGSSKIADLKSSSGEHLSELSSLQRVRKRRDVVSGGLQVQGLSASQGCNGIILEWDALPLPYSAKLQYVSSEFKHFNVYRSNSFFSDVTGMAPHASGVTDPRLRAVDNRRWIDFYPPPMANWFYAVTIVDGKGREQTRVAAKKVIFVGAIEKEGKPFLMIPSVLRGRAMHHSVAFNPNRNEYLVAFDWDMNHDGTSDHLYAARLDQAGKIVDKKVLNFSASIPGWVSGEQGWPAVAFNPSSNEYLVLFHFRSTKHFSNRHVILAQRILAAQSERAASPSVTATADGADIKEPKLLYNPKTGGYVASVVVTKPKKDVIGLFLDKNGKVAKVGQVCSFRYDAYEHNLFHDSKRDEFYFTCTIENKGTIANPQLETRPFMVLMTKMDAFGVHASNTPSSGTKTLIGYSNKRHTRHEGYYNQKTDRLVMFWEDLKNGKNTLSSSSLLMTRALFLLEVGKYDCHLDREVKTPVLLPMPISGGHYLLWQERSQLSWSIGGQLMKDGNFRLTSGIQKNPTVVYNVNRDMGFVVWQEDVGRQVKLIGRHFTYSSSHTCSSACPPNQRCVQQNTCDSDRCSSNNGGCSHKCQVKAGGLLTQCICPKDMELDADQKTCINNLPCRGMTPMKNPLTSQDMYCGRGPLHVDCLEGSYCHIHPTDKFAKCCPDLLPGYAILVASQNTIWKAVINENQQKANVSRMPFTQGFMQVVAIAYDPKEKRMYWSDVMGQTIKRALMDGTGEETILRSNVHTPDGLYLDTVDRELYWTDAGQETIEKSKLDGSGRRVLVNKGLDQPRAIVLYKKRRQMYWTDWGKIPKIERSLEDGTTRETIVTRGLGWPNGLAIDEDLRQLYWADAKVDKIETSDLEGRNRRVLVGGDKAKHPFSIGILNNRLFWSDWEKEGVQSVDKQTGKDYAEILNGLENPKGMFLFMTESQPLNTCPDPGRPNNGNRFPAPGPTGRYDVGVSLIFTCNPGYTLIGPINRQCKRTGKWSRKVTECVAPPFLTATPINTTVDEGKAAVLRCSSSIDRSHPIQVQWFKNGSPLAPDPDIRYHVAFTGHLIFSLTRYSDRGLYKCVAQNKGGKVSATAHLKVRGSVKLKVECGRPGFNTRARIIGGRRADRGAHPWQVMLWNKLDKRHFCGGTLITDRWLVTAAHCVHAKLLFPSNIKIRLGKHVRTRTERNEQSMNADMIKIHPNYNAMDRTYDSDIALVRTSKKVIFTDYIQPICLPTKEQDFQLMRVNTSGVISGWGSRKVFRDSARRLYEAGVPIVSTSACKASHPAYIITPNMFCAGQKNSSLGDACQGDSGGPFSVNSPLPSKRNVKRHVLLGVISWGDGCGHYGKYGVYTRVTNFVDWIMNEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4P2</accession>
    <name>A0A6P8I4P2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding motif protein, X chromosome-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116299044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563529.1">
        <property type="nucleotide sequence ID" value="XM_031707669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4P2"/>
    <dbReference type="FunCoup" id="A0A6P8I4P2">
        <property type="interactions" value="1903"/>
    </dbReference>
    <dbReference type="GeneID" id="116299044"/>
    <dbReference type="KEGG" id="aten:116299044"/>
    <dbReference type="InParanoid" id="A0A6P8I4P2"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563529.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="32981" checksum="3C483BE147B3B6E4" modified="2020-12-02" version="1">MSGDGKKKLFIGGLPSECDEKALASAFSRWETEDIIVVYDRETRRSRNFGYVTFRDDRDASDAMKQMGGESGKGKEIFGRALNIEYAQDKESARPARRGGGGGGPRGPPRGPPRGPPPGRGPPFGRDMSSGRGPPPRGGPPPPAPRRGPMPPERDGPYNGYDRYDRPPPDRRPPPPDRSGYPPQRDYERERPPSYGSDRGYADKYPPPDRGYSSSDRGYGPPGGDRYGSERAGYPDRYSSTDRYPPADHGYGSERGYERSSYGASGDRGYGASSDRGYGAPYERSSYGPPSSGGGGYSAGGRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4X4</accession>
    <name>A0A6P8I4X4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116298275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031562526.1">
        <property type="nucleotide sequence ID" value="XM_031706666.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4X4">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="GeneID" id="116298275"/>
    <dbReference type="KEGG" id="aten:116298275"/>
    <dbReference type="InParanoid" id="A0A6P8I4X4"/>
    <dbReference type="OrthoDB" id="5964716at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031562526.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="50027" checksum="EFB125E3E608786B" modified="2020-12-02" version="1">MAKXNFQTRFRLGGLKMLLVLLILLVYFQLLIFWSVSSKKHDYSQSFQEQKEAKGTKNLQDITLNHRGINKILQTQMVLSYQPRTKSFTKQKEITTETQKPRTTTLQPSSPTTLQGSTNNSSEKTTLKHLFTTKKSADMENDYYPFVDFSFVWPETMPDLKGERDFFLVVVVNSAARGEKYRLRREAVRKTWAKHVTKCELLQSAKLRNHKWILVFSLGKAGEYADDKANAEEAKMHNDVLIGDFEDIYINNVIKMFMGKLWVSSMNVRYILKTDDDVYVQIPSLIDFLVTQGYPKPFYGGAPYFNFKVDRDPEGKWAISKKYFSEDIFPTFCAGAFYVLSTDILPKLFNYVRRRRPFHTDDAYLGIAARDMNITVQRIPGLLLEPSMSDILRGFDDCKLIQARGYGHDVDPPTMNIVFNRLEDLCRKNFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I511</accession>
    <name>A0A6P8I511_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 12 member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116299144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563639.1">
        <property type="nucleotide sequence ID" value="XM_031707779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I511"/>
    <dbReference type="GeneID" id="116299144"/>
    <dbReference type="KEGG" id="aten:116299144"/>
    <dbReference type="InParanoid" id="A0A6P8I511"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031563639.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62216" checksum="82CF69E683D1D621" modified="2020-12-02" version="1">FQQVNWGSSTQAYTYIRALRFAYRLARVEDHVKNFRPQCLVLTGAPSSRPNLTYIVSQMTRNVGLMICGQVKVGKFCKPSAYENRWLRKQKIHAFHTICTAPTLREGVQSLLQIAGIGKLKPNTLVLGFKNNWIRAPPSEIAEYVNIINDAFEMNYGVAILRMSEEYQMEEEECDDDDWMGDKEEERFLPKTRNLSGSKDSLSIRPESPSHGSQVFSDKPQDASRKIFHVERTATPESSSLLAEIFDSIGDDAEGKQKQSNDDKKEFVVAKNVDLNSDKKDTSSVSDSAAPTSELDFPSGSTKVEVGSLATREFSVSEFRTSDSNISQTLTVEIEKTKEVSSKQSPSLSPSHETSVDPLPVRQEPVMEYSPSSPVSFQGKQRGTIDVWWLSDDGGLTILIPYLLSLHHSWKNCKLRIFTHATSGNIQDNIVRMANLLKKFRIDFSSIEEVKGIREPPSKESVEEFLKLPIRSEFEEGGMQMDKRILRHIRIGELVRKHSKDARLIVMTLPVPKVEIMSCMMYMSWLEVLSADLPPVLLVRGNQTSVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5B3</accession>
    <name>A0A6P8I5B3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C-Jun-amino-terminal kinase-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116299249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563739.1">
        <property type="nucleotide sequence ID" value="XM_031707879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5B3"/>
    <dbReference type="GeneID" id="116299249"/>
    <dbReference type="KEGG" id="aten:116299249"/>
    <dbReference type="InParanoid" id="A0A6P8I5B3"/>
    <dbReference type="OrthoDB" id="5971741at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01212">
        <property type="entry name" value="PTB_JIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000032">
        <property type="entry name" value="Putative C-Jun-amino-terminal kinase-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047178">
        <property type="entry name" value="JIP1_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="161"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="337"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563739.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45526" checksum="9F835AB6915A9098" modified="2020-12-02" version="1">MTSEYENKGTYPYEINEITRGINALATNLNEQRNFHSTMENQRSPSSNSYVNSSKRIQRREYNSQMDDSGAYNGNYRQYYLPPSPRNNMASFQTGYPISSQPTLPQGVNPPYQMRKTQIGTVDARLTSPLDDPSQNRISDLSISSSGSYSSHSSTDEISNLMRQTHIAVYKFNVRHEDEISLEVGDAICLLKSHDESWFEGTNLRSGQTGMFPSRYVSDILQYAKKRDSSSSLVSSNSSDNNQFYLRFLGSVEVADFKGNEVLCSAMKEIVKQHQMASESSPPYCTLDISIRGIKITEHQGQLSKPLSGKKPSRNKITKLFDKDQSDLPESCHFFNLKNVTFCGCHPNNSRYFAFITKHPEESRFACHVFMSEFSTEPVAYAIGKAFKEFYNEFLDYQSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I794</accession>
    <name>A0A6P8I794_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296941</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560922.1">
        <property type="nucleotide sequence ID" value="XM_031705062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I794"/>
    <dbReference type="GeneID" id="116296941"/>
    <dbReference type="KEGG" id="aten:116296941"/>
    <dbReference type="InParanoid" id="A0A6P8I794"/>
    <dbReference type="OrthoDB" id="5990085at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560922.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45029" checksum="0CD232A785C6B530" modified="2020-12-02" version="1">MSFEKKSTFSSPLKHSTRKGGAVEQWETELLKAFHGQIERKLVVEDQAFTNLDPRNMTSELKSTQKMILRTAQQASKDESIILTRFDPNFMSPREIRCRSPGCKQTKKRQPSLTEPSKEDLYLCPRHRKLLEDYVTKICAEKGIDVGTKYLAGDFEGYISMIGMLESAYFLFVKRPRGTENILKGKPEILKEIFINLRNFLMITNALLNPGWENLFTVLPRVMEIFRDILKILSTDGENIVQRLTELVGLLRSVMQDILFTFGIVYSWVYLTVINANPGAKIGAGIGGFIGMAGLFVASPPVALLAMAGGSIFGGLTGSGIYNLQEQRRQEQEAEESHRRYQEFVIMQRNQENQNEVQAGNNPQVMAEPDGGDVLFHITGSERGDSCLIILLAARLYFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7Q7</accession>
    <name>A0A6P8I7Q7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box/LRR-repeat protein 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563301.1">
        <property type="nucleotide sequence ID" value="XM_031707441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7Q7"/>
    <dbReference type="GeneID" id="116298863"/>
    <dbReference type="KEGG" id="aten:116298863"/>
    <dbReference type="InParanoid" id="A0A6P8I7Q7"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013101">
        <property type="entry name" value="LRR_PRU1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07723">
        <property type="entry name" value="LRR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563301.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="51474" checksum="0DA19A2DF3CCC1A4" modified="2020-12-02" version="1">MNDQGNEKVGVTERNTGENEIKHKDDSTLEICERKERQDKKKTSPPDDLSPPMKALPDTVLLKVFSYLPEEQVCKVASVCEAWKRVAYDSSLWESVDLRRFHTTLDEIRLTRLIRSRMIPLLQKLNLGGLSLSPRVFQILTKDCPKLKVLCLESVTFLENFNATENCFPNGLSTLDLRHSSGDESAFQVIAQNVRQVENLGLSDHCITSLIVSNDLDAVFPRLSNVRVLEFSYCVALTDTMISDIALYSKSLRSLCLRRCNTFQGASLALLIASCPLLTSLVLDGTCVNDSALRAVDWENSALTEVDLSWCRHLSSEGLKAMLPHLSKLRYLRLCCVGYGHAVTDDLLYVMSATRNQTLEILDMSYSGSVTDTALGYFAIEHEALLYLRMHHCRLITPKIMDLIPQDSQVFIVANFPIDNEGMVLNSELLNRYTYWPTPIYMRDWSLDQRMGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7T5</accession>
    <name>A0A6P8I7T5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116300009</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116300009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
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    <dbReference type="RefSeq" id="XP_031564629.1">
        <property type="nucleotide sequence ID" value="XM_031708769.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CD59_antigen_CS"/>
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        <property type="entry name" value="PROTEIN SLEEPLESS-RELATED"/>
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    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028253742" evidence="4">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031564629.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15309" checksum="708CB17A6E47A73F" modified="2020-12-02" version="1">MELHFKTKGIFLITFFIIAVFVLKGYAVECFACGSDNSLDECHGRIKKITCPNGFDRCLKANWTAALFGDISEGFLLGCARSTMCKWQNYTYCTQTSGKISCGIHCCENNFCNXGSIPGLSLTFTIFVVILSIFLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8T6</accession>
    <name>A0A6P8I8T6_ACTTE</name>
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        <submittedName>
            <fullName evidence="6">Calcyphosin-like protein isoform X1</fullName>
        </submittedName>
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        <name evidence="6" type="primary">LOC116299161</name>
    </gene>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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            <end position="76"/>
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            <end position="193"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563651.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24216" checksum="E63A2CACFD58D12F" modified="2020-12-02" version="1">MFTGRKNEELRRKTTKILKGNTKDIHPVEILRLKCLSRGCGGIMGLGRVFRIMDDDGNRKLDFAEFKKGLREYGLILEPKEVKSIFDAFDKDGSGTIDFDEFLISLRPPMSKARKSVINLAFNKLDKTGDGQITVEDLKGVYNVKHHPKYINGEWTEEQCFRKFLDSFDSPDDKDGVITLDEFLNYYSGVSASIDNDAYFDLMMRNAYKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBT9</accession>
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        <submittedName>
            <fullName evidence="3">Protein FAM149B1-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC116298105</name>
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        <name type="scientific">Actinia tenebrosa</name>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031706475.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="116298105"/>
    <dbReference type="KEGG" id="aten:116298105"/>
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    <dbReference type="OrthoDB" id="2134133at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="FAM149"/>
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    </dbReference>
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        <location>
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            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562335.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="32973" checksum="05494CD5E3905EC3" modified="2020-12-02" version="1">MMIKSLALQHRAPSAAAIHPIDSREGTPYIQGRPGSSSTVASRMSRFGRVPDNFLNRMASAKTRRNPASQRLAPLERERPKTPNTQEDVKCEIVRGTKLLPGGERLTSPPHPLNTSSPQPWGARNGTLPPLERTVSYGESTAAVSTLVSASTTGSSNQTLHSAARSSAKAKVHFNVRASSAATDDSRRSLRERAPVFSESRPNTTHSFRTDTPSANANNRRLSTPMNNFNHSRGVLGTNRQPLDLGGITGVSMSISAGPPGSDLHTSHSGHHGDSRGISPISDEADEVESYFGHAGHQRRGRLGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDD2</accession>
    <name>A0A6P8IDD2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
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        <name evidence="17" type="primary">LOC116299624</name>
    </gene>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564162.1">
        <property type="nucleotide sequence ID" value="XM_031708302.1"/>
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    <dbReference type="GeneID" id="116299624"/>
    <dbReference type="KEGG" id="aten:116299624"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hvcn1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="60"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031564162.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24582" checksum="2C0F735F34DAB163" modified="2020-12-02" version="1">MDPDDQQLVGRLSFDELSTDTAEMEVGGAGDSNLEVVPSTPWWKDNRAKLRELLHSQKAQYTVVGLVVLDCIIVIAELIVDLQILKVHHDNPAPHILHYISIAILSIFLIELILKMYAMGLDFLRHKMEVFDGIVVVVSFALDIAFSGSESAAEGASLLVILRLWRVTRIVNGIVMSVKIQAEKKIEQLTAENDELKEEIIKIKTRNAELEKEISALKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDG2</accession>
    <name>A0A6P8IDG2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Complement C1q subcomponent subunit B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116299674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564242.1">
        <property type="nucleotide sequence ID" value="XM_031708382.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564244.1">
        <property type="nucleotide sequence ID" value="XM_031708384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDG2"/>
    <dbReference type="GeneID" id="116299674"/>
    <dbReference type="KEGG" id="aten:116299674"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22838">
        <property type="entry name" value="Gal_Rha_Lectin_nemgal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653168" evidence="2">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="3">
        <location>
            <begin position="150"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031564244.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="27741" checksum="B1BFC3AC3467E19B" modified="2020-12-02" version="1">MRIVCPGISLFIGLVLFHYSASLPVSPVPPLLNKLLKDQNVTLGFILKGLQGPPGTAGQNGMSGSPGPMGPMGLKGDPGMPGMPGPPGMPGSPGLQGPPGFDGMPGAPGMPGPAGMPGGSGMPGPPGPPGLTGPPGPAGPTPIRYNGTVKCEEDTAWLRCNEYKHISIISAFWGRRNFGLCTEHTGNLKYDKYCPTSPLFTTKVKDTCEGTTMCEIKCTKFFFHDQSCLDVYKYLEVYYKCIEVINGHEVVNEDNLLNANFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDJ7</accession>
    <name>A0A6P8IDJ7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116299750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564332.1">
        <property type="nucleotide sequence ID" value="XM_031708472.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IDJ7">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="GeneID" id="116299750"/>
    <dbReference type="KEGG" id="aten:116299750"/>
    <dbReference type="InParanoid" id="A0A6P8IDJ7"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="11">
        <location>
            <begin position="242"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031564332.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="54002" checksum="2CA05AD3C4DAADB1" modified="2020-12-02" version="1">MSISIMASTFLNNFRHRPICLFLRSRLSLQGIRTFHHPGRSSSFRFLNQRXVPFRYWNLSFNRTQRCLLSNNCNHSRFYEIHCWSREHWFRSEGWKDVCCRLRGRYKYQSFHTSARRDAWPIAALLVKFVGPLSKVLKLVAMVGGRSFRKWYQKLSPKYKLQLLNDKRTEKLVIISGSIGGLFIAYYFFHLEETPVTNRVRFMPIGNAQMEHLVESEYKQTLELCGEYILPVNHPDHIRVFQVTKRLLKGNQSKETDGIKWQVNVVNTADXNAFVLPNGQIFMFKGMLDMLSNDSELATILGHEMAHAILGHGAEQASLHGXINLFIVVSLAILWAVLPTDYIAIAAQWIQDQILTILLHLPYSRKLEEEADEVGMLFAAKACFDVRQSPKVWKRLAAQQQLKGNTDVEWLSTHPSHATRANNLESLLPEALEIRKECNCPTLESLPPLLVTTQXRLMKLFGVKMAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFK5</accession>
    <name>A0A6P8IFK5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor C domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565524.1">
        <property type="nucleotide sequence ID" value="XM_031709664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFK5"/>
    <dbReference type="GeneID" id="116300742"/>
    <dbReference type="KEGG" id="aten:116300742"/>
    <dbReference type="InParanoid" id="A0A6P8IFK5"/>
    <dbReference type="OrthoDB" id="5959272at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565524.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19113" checksum="A90F8B57EB2E06A6" modified="2020-12-02" version="1">MNGKLLSHSFIHSFIHSFIFVALFSKCKKKKWSCNRDPHHGFTDISEKPQCIDEVRDEPVRVWAVWLPSECSYCQCGNDGFGNCSMVNCANPRCEDSFKMKGRCCPVCPQDFQTMCNYDGQKYITGEKTVLPDRCTICTCENSRWQCSSKGCKGSKFLREPLHISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFN4</accession>
    <name>A0A6P8IFN4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitogen-activated protein kinase kinase kinase kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116300773</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031565566.1">
        <property type="nucleotide sequence ID" value="XM_031709706.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFN4">
        <property type="interactions" value="2501"/>
    </dbReference>
    <dbReference type="GeneID" id="116300773"/>
    <dbReference type="KEGG" id="aten:116300773"/>
    <dbReference type="InParanoid" id="A0A6P8IFN4"/>
    <dbReference type="OrthoDB" id="6017484at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06608">
        <property type="entry name" value="STKc_myosinIII_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000003">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000006">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="16">
        <location>
            <begin position="594"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="423"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="26"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031565566.1"/>
        </source>
    </evidence>
    <sequence length="909" mass="102525" checksum="AB2F41E9ADC1974D" modified="2020-12-02" version="1">MAYGLDDIDLTTLKEPAGIFDLVEVVGNGTYGQVHKGRHKRTGQLAAIKIMDVTEDEEEEIKLEINVLKKFSNHRNIATYYGAFIKKALQGQEDQLWLVMEFCGAGSVTDLVKTARNKTLKEEWISYICREVLNGVSHLHLNHVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDEQPDATYDNRCDMWSIGITAIEMAESQPPLCDMHPMRALFLIPRSEPPRLKSKKSWSKRFHNFVNTCLIKDYQHRPTADQLLQHEFIRDPRANERKIRIELKDFVDRMRKKKGGYSEHDGPDYQFSGSEDEDEQLLAVMIAEDMVGSSDNPRSTLRRNLTLMQGGTYKANHPHETPYRSNSVSSPERRQAPAAYGVGTGVYDNEMHPAYSMETNQEGFAMGHAENNVPAAQPNRPGSLSIDGVDERTLTRHNHDTAREEAEAVXEEHEEYGTLRLDDEDNQSDSSSSTASLTESESPTRGSNLPDVLPATSQPPQSPPSSRSPGQQSSDESIASSFAAVQEPAKEKKMVKQRSFGFGRQSQAPSEVSVNLDPERTSIASQEDFAMPQIRKYKYKFRTEVLCGALWGVNLLIGTETGLYLLDRSGNGKVFQLISRRRFQQIDVLEGINVLITISGKRNKLRVYYLSWLKAKILKGEEGNHRGQRGYTVVGDIEGCIHYKVVNFHRIKFLAFATQSSIEVYAWAPKPYHKFMAFKSFPELKHQPVLLNMTIEKENSKLKVCYASKVGFHAVDLDSATVIDLYIPTKLQEPFHPHSIVTLPNSSGKELLLCYNTEGVYVDTDGQLVRHATMQWGETPYAIASIGSCQIMGWGEKAIEVRSVETGLLDGVFMHKRAQTFRFLCERNEKVFFASRSTSSGQIYFLTLSKSFKNFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFZ6</accession>
    <name>A0A6P8IFZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ophiophagus venom factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116300842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565659.1">
        <property type="nucleotide sequence ID" value="XM_031709799.1"/>
    </dbReference>
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        <property type="interactions" value="685"/>
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    <dbReference type="GeneID" id="116300842"/>
    <dbReference type="KEGG" id="aten:116300842"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02896">
        <property type="entry name" value="complement_C3_C4_C5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
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    </dbReference>
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        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
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        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
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        <property type="entry name" value="A2M/Complement_sys"/>
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        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
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    <dbReference type="InterPro" id="IPR002890">
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    </dbReference>
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        <property type="entry name" value="MG3"/>
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        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF166">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NTR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027613734" evidence="8">
        <location>
            <begin position="17"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="9">
        <location>
            <begin position="1600"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="968"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1406"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1406"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031565659.1"/>
        </source>
    </evidence>
    <sequence length="1735" mass="193873" checksum="62CB42F231798341" modified="2020-12-02" version="1">MKILLLVSLLVGGCAASIPRHVIMAPDVFYVGVPQKIHVALFDVTSPHNVEVKIRVLLPANPQWKTISSDRAVFSKDHLSGLLSLTVGLDNASDYLTRGNNWQFFLLAKISDSHQTFTTKPVKVAVSYSDGIVLIQTDKPIYTPTQKVKIRVVPLGFNLMPSTKKINLAIKNPQGIRVRQWNNLSTDSGFISQVLDMGTSAMVGNWTVEVYYGHLFVHDTSKTFEVREYILPKFSVTIKGPHYIMSGSSPLKVSIEAKYTYGKTVEGTVSVRLDVVGILKEPRRLYSFRSLLRKGTFKFDVKVENIQKLLGDKWFPAIEGHRLQITADVTEKSTGKTETAVDDSIYFVVSPYRIKYIDTSRFFMPGLPFQLKVRVTYPNKENAADVNLVLETKSLDENDKDLESQSFVKQAVDQTVATTDNNGVAMFVVNVPSQARKLIISVNASEGAIANGQNAYKTLLVEASQSDELMKLKQHKPAKIGDSAGCEAIISSLSVNQLSYFVVSRGQIVYNGKIDARVGVGIVTTLPFKITSSMSPSARLVAYYVNKATKKIVSDSILLEIEDTFPNQILFVPFNEKGDHLPGHLYELKILGAVGTKVSLLGVDQSVYLLSRMNLLIPXSVFKKLEQLDLGCGAGGGRNAKDVFKNAGMVVISHDMVLPTREREKCGTELRRNKRSIAGMQDHLDFCCNLGNETDPNNRNCYRRVMELDVGILKDQELIHDCKTKYLNCCITAFGLGDVGILARSGQPENFMNDEEDLTNIALRQFFPETWLNEEIVISDDTKSKDCKKLHLDPQSKCGSAVLPVSLPETMTTWVVQAIGVSNTTGFGMAEPLXITTFKPFFIHLSMPYSVQRGEEITILATLFNYKKYDISVYLYLKGDKSFCSVAQPGKTSRLTSNKIKVKRESSVSYAINLLPIKFGEIPIEVTAKGLYADDRILKKLLVVPEGVEEILTQSYVLDPKEFFKGRKEQGEKQQNDADKLSFQSEQAHNTSRSEQVDKILLKINKKAVPESVDAKVYLTGNMIGPAVTNIAVGQLKHLLYLPYGCGEQNMNAVGPNVYALHYLQATNQMTKEMESKKNDYIQQGYARELNYRQEDGSFAYFSKSNRAGSTWLTAFVVKVFCQARKIKGIKIDKEVLCESANWLLKKQRKEDGVFIEDLKVKYIRGMGYHGNVGAYTSDMTLTAFVLIALKQCQCGGYQENASVQRATTILKESISNLTDAYTLALTTYALILADSPEKMRANRLLVEMATFNSATSTRYWETGSRTRNIKTAAYALLAQVALNRLEYAGPIVVWLTKQRGPKGGFASTTDTTVALEALAKYSELANMNKLDMKVWIKNKSKKLNKDTALLQQEVDIKPYIDKELMVESRGTGVGQLQINVKYNVPSKKKDKCDFHLSIKITEDESGKLVSKTESEGPQKGTRMATQGRKRKGKKNKRKGKRGXKRPSKRRTGHKKPTKKPLQKHEIPKKLIVSICARFKKRGTTGMAIIDAGILTGYSVIEESLAKLVKKDNSSIERYELSDRAVVFYLDRIDNVKPLCVAFGVFRDFHVGGIQPVPVKVYDYYEPDDSCTVFYNLGPSSKSVGKCKDTGFCKCTQGKCPLANPSLGNAGRLKKRICKQFDYAIKGQVVFIDEDNTWLTYNVLVITVLKQPGKDVQLINATNVIEFRKQAICVNPHLWMKETVLIMGQIKHGLYVLNNDAFVKKLDKNEEEYVDKLAARIKRRGCGSXSETFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG84</accession>
    <name>A0A6P8IG84_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fos-related antigen 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565767.1">
        <property type="nucleotide sequence ID" value="XM_031709907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG84"/>
    <dbReference type="FunCoup" id="A0A6P8IG84">
        <property type="interactions" value="1788"/>
    </dbReference>
    <dbReference type="GeneID" id="116300932"/>
    <dbReference type="KEGG" id="aten:116300932"/>
    <dbReference type="InParanoid" id="A0A6P8IG84"/>
    <dbReference type="OrthoDB" id="2596881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14699">
        <property type="entry name" value="bZIP_Fos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565767.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20535" checksum="11DBFAFDE18D086A" modified="2020-12-02" version="1">MNGLYYSMNSEGNYLVLQNRAMPVPMDDSDMESNISSEDAGNFSEFSNPQTPPLSKGAADEVKLELQRAIRCRRVAQGLDEMPSLESQRSNSNQLSAAELEKRRLRRERNKLAAFKCRQRRKEHMQALEEETDGLNSANHTLETEIAALKEQKRELEEMLRSHDCLIVVNSSDEEDKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II92</accession>
    <name>A0A6P8II92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC116301511</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC116301511</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566442.1">
        <property type="nucleotide sequence ID" value="XM_031710582.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566443.1">
        <property type="nucleotide sequence ID" value="XM_031710583.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566444.1">
        <property type="nucleotide sequence ID" value="XM_031710584.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116301511"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653195" evidence="1">
        <location>
            <begin position="25"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="340"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031566443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031566444.1"/>
        </source>
    </evidence>
    <sequence length="687" mass="76693" checksum="2CAB2D628E8E6A10" modified="2020-12-02" version="1">MTSRGYYFVLAVCILLGSCVLLQAKDTNILKRAKRKTPTVYDIYALNHFIELVEKIEKNVTKLYDVATYIRQVGYDNDYWTTVIGTALPLPSGILSRTEIDVLRNMVAHRYDRSREXGVILTPAGKTIAIGHVINGICAGMVRDKEITLAKWSPGAENEIDNLFAATISRDVAQAXLXKKNDAXLPYFGPGGSWDDTKCPEVYTRSPDVSTGASDAELLGDIDGFLLGYYLPRWVSKGVRLGQLLRMYYSTGVCYDMSVASCKRYSKFKSLVDGEGLYEEIYAVAKAIYLKNSASYPNVKREDISKATKTTIEKFLPYIAKLQNDQKCPEKEEGCELPANLVFVMDESTSIRDRHFKVEKDFVRDIIDAFNVSPQQTKVSIVEFSDSAAIDIGLHDYSSKTRLKCAVNNLRQRKGYTHTAEALQLVKDDIFWPLQNDQAATTTSKSDVSNIVILLTDGKSNDPDKRALQRVVRQMKNEIRDLTMISVGVGNYDYNELELIATDPYKHVFTANDFTALLLLVKRLQTRTCTTPVQMDLDFKVEGNNTIVTAYVYPGSFRYFALAPRFFYGVKDIDIAIKPIYGSLKIYASRIADTPGPSNHTYKLDPIAIGQQMSLHISNPCSGYNETTCPPVYLGIYADQVSCACTEPECTVPGQIKFTIQKGTGGVKQVQASLLFVLISLALSYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIY5</accession>
    <name>A0A6P8IIY5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566729.1">
        <property type="nucleotide sequence ID" value="XM_031710869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIY5"/>
    <dbReference type="FunCoup" id="A0A6P8IIY5">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="GeneID" id="116301753"/>
    <dbReference type="KEGG" id="aten:116301753"/>
    <dbReference type="InParanoid" id="A0A6P8IIY5"/>
    <dbReference type="OrthoDB" id="10054259at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:cilium assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF25">
        <property type="entry name" value="TEKTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566729.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="55247" checksum="14586EFF5F2CC397" modified="2020-12-02" version="1">MTTQSFVETAKYLSSSSFDPPSYLRPTGGPYETTYTASFQGIRPHTTPYSMRPITLSRSYEFPSKILQGSSSGLEHLPYTAVNQRAIHKYSPQQWRSSNLLNVSSGEKERATAERLRDECSRLRTETSLRTHRTQMDVNKKLDNRIHDISYWKAELEKQHNETVAEIKALQAFIGRLEKALAATEKPLNIAQQCLGFRERRVKIDLVHDSVENHLSKEVEMIENVQALLKKTMDQAHEQLWLLRNAKTQLEKDLGDKYGALGIDGKCSTLNNFSKEIHFAPHSVTIQQHSFTPDEWEAYSSENIAKAERERKASVALRSEINGILMQTYVDLKNIYETVNNEFSKRIQDTDAAKKSLEKELARVMDEISSMENNIRDLRMAIGEKEAPLKVAHTRLDKRSIRPNVELCRDPVQYRLVGEVGEINTSIDRLRMRLAEAEGSMQALVRNKENLEDDIEVKTNSLFIDRDQCMVIRQQVRHISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJM7</accession>
    <name>A0A6P8IJM7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PR domain zinc finger protein 14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116301906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566935.1">
        <property type="nucleotide sequence ID" value="XM_031711075.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A6P8IJM7"/>
    <dbReference type="GeneID" id="116301906"/>
    <dbReference type="KEGG" id="aten:116301906"/>
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    <dbReference type="OrthoDB" id="3565419at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000905">
        <property type="entry name" value="PR domain containing 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PR domain zinc finger protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000480">
        <property type="entry name" value="PR domain zinc finger protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF19">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566935.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33456" checksum="89524709AB2A27F6" modified="2020-12-02" version="1">MKFVRCAHHANEQNTNLVQRGSKLYYETTRDINEGEELLVWYGDGYEMVMGLPLKLRTKEQSQQDGLTNSPSYPCERCGKLFAYDYYRDKHLKYTRCLDKGDRRFPCSLCDRSFDKRDRLRIHVLHVHEKHRPHQCTVCDKRFSQSSSLNKHMRVHSGERPYRCPHCEKAFTASSILRTHIRQHSGEKPFKCKHCGRAFASHAAHDSHVRRTHLRAKTWTCEFCGLSFSDVKQLHFHRTVHGQEGPFSCEWCHRKFQSRFLRDIHQNSFECLVGERIPTSPMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL23</accession>
    <name>A0A6P8IL23_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable calcium-binding protein CML16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567467.1">
        <property type="nucleotide sequence ID" value="XM_031711607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IL23"/>
    <dbReference type="KEGG" id="aten:116302322"/>
    <dbReference type="InParanoid" id="A0A6P8IL23"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567467.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18932" checksum="9DEC54E22BCB7AE0" modified="2020-12-02" version="1">MEAGEKYLTLSTPDVVIQSLFSKYDLNKNGFLEEEELRSLLEQDLGMNTDQADVFALLIDKNGDHRVSYTELVDWLHSDERYRCINDKSRFYLISKAVELFKQFDRNENGSLDRKEFLRLVRSLGYQQVNNDKEFQTMDSDGNGVISFWEFLRWLNWIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN87</accession>
    <name>A0A6P8IN87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18">ATP-binding cassette sub-family B member 6, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC116303158</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568501.1">
        <property type="nucleotide sequence ID" value="XM_031712641.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568503.1">
        <property type="nucleotide sequence ID" value="XM_031712643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IN87"/>
    <dbReference type="GeneID" id="116303158"/>
    <dbReference type="KEGG" id="aten:116303158"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015439">
        <property type="term" value="F:ABC-type heme transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18581">
        <property type="entry name" value="ABC_6TM_ABCB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032410">
        <property type="entry name" value="ABCB6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16185">
        <property type="entry name" value="MTABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="171"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="242"/>
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        <location>
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            <end position="326"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="445"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="451"/>
            <end position="471"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="306"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031568501.1"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031568503.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="73264" checksum="21F8164406E3F7B3" modified="2020-12-02" version="1">MKVCSIYCEFNESLIHGASEDEGLPRCIMETYPPAILLALILFIGLVKYIQRKERYKNAYRNFDSTEDAESGPVPNNEIPHDIRFGTVNRTNSKENGHPQIPNPVKFVHGTDQMSFLFTFQQFLHVCLMIVPLIDFATKGGLDSSRLQGVTIFFDAASLLLWLIGLLVLRYESIAFFKAKRSSHSLGMILFWGLAFINENLSFISWNNKHWWFEHKTTIKQVELGLFITRYVCISLLFLLGLKAPGLYKPEPVLEVHVRERQGPNEATSVVSDRSGQSAFKDFWKKCKMLWPFLWPSNRWLQLKVVVCFILLALGRVVNVLIPYSYKLIVNKLTGVGNHKVVDPYALIGIYVALKWMGTGNSGALSNLRTFVWIRIQQFTSRTLQVRLFEHLHSLSLRWHITRKTGEVITMVNRGSNSIYNLLNYILFNIVPTIADIIIAIVYFIVAFNGWFGLIVFISMSAYLASTIIVTEWRTKFRRDMNIRDNDAKAKAVDSLLNFETVKYYAGEEFEVNRLNDAIVGYQECEWKVLGSLAILNTAQNTIINVGLLVGAMYCGHLVVNGTLGVGEFVQFITYMVQLYVPLNFFGTYYRLIQSSFVDMENMFDLFSQGREVLDPPDATILNVSNGLIEFKDVSFGYNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INF1</accession>
    <name>A0A6P8INF1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-24-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568394.1">
        <property type="nucleotide sequence ID" value="XM_031712534.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="RAB"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568394.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26086" checksum="9EB425E0FB0AA70A" modified="2020-12-02" version="1">MTEARSELKIVLLGKENGGKSCLVVRYLHKRYNPENVSTTIGAGYGSHRVIVDGKTVVLGIWDTAGSERYNAMARVYYRNAKAAVVCYDLTDDTSFERAKFWINELRKYEEGCKVYLCGTKLDLVQDDPSCRKIYSEMAENLGLEIGSKTFETSSKTGENVEEFFYEIAKDSLMVEAEQETRRDPLGPVKLYTHQMMRPEIELEISEVSANEVFLVDRGKAKNQIKFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQA0</accession>
    <name>A0A6P8IQA0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional peptidase and arginyl-hydroxylase JMJD5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116303650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569089.1">
        <property type="nucleotide sequence ID" value="XM_031713229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303650"/>
    <dbReference type="KEGG" id="aten:116303650"/>
    <dbReference type="InParanoid" id="A0A6P8IQA0"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000025">
        <property type="entry name" value="Lysine-specific demethylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF18">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028155748" evidence="3">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="116"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031569089.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="48107" checksum="0B5CCD5F88D900D9" modified="2020-12-02" version="1">MKPLLLLGFIFNVVQGNSDHPSGHLKPLGSHQEPEQPITELHGAPSPKDFFENFVKPGKPVLFKGAAKKMPSFSLWTDEYLSKKFGGLKMDVEEGKKENRSWGTFNFKLQDFIKRYKTEDVYMVESLPKQMQEEYMLLKSLHCGGFTDVLQDAVMWFSSGGTKSVFHFDAVENINCLFSGSKQFVMVDKIFKPQAHIDKVDGSYSTVDVEKVDMYKYPGLRNIPWYNVSMMEGDCLYIPYMWLHHVRSYGTRNLAINIWWAHFTFFNESDCKTSKYKDTEYLPLSSFAFKPMETTRQRILEELGRKSVTQDXWIEMSRKLATALLLEQNTKEAIIKNFQELDKNKDGFVSAEEILDLESSDIERLLTPGQLPEEENEEEEEEDYPPAKEEEVKSEESTIEKLVEAKNERVGIKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQJ5</accession>
    <name>A0A6P8IQJ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mucin-5AC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303877</name>
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    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569346.1">
        <property type="nucleotide sequence ID" value="XM_031713486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303877"/>
    <dbReference type="KEGG" id="aten:116303877"/>
    <dbReference type="InParanoid" id="A0A6P8IQJ5"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032715">
        <property type="entry name" value="NCOA6_TRADD-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13820">
        <property type="entry name" value="NCOA6_TRADD-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear receptor coactivator 6 TRADD-N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
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            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
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            <begin position="585"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="679"/>
            <end position="714"/>
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        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
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        <location>
            <begin position="989"/>
            <end position="1018"/>
        </location>
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        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
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            <begin position="433"/>
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            <begin position="588"/>
            <end position="616"/>
        </location>
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            <begin position="863"/>
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        <location>
            <begin position="913"/>
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        <location>
            <begin position="1007"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF13820"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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            <dbReference type="RefSeq" id="XP_031569346.1"/>
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    <sequence length="1018" mass="108572" checksum="CD8292D4E0F1D6ED" modified="2020-12-02" version="1">MHLKTSNSTGNRARPVTVNFPLPRKAVSKLRALAIAKDPRLLDLGVLAVQITDDESIVLGIELDKTKKKSAVYVNKAASPSYAHSSVNRVSFNPKTVDPRSFTTTTTFDPLTHRYSGANASQLSQAARXVSFVSKTKKLAQNSAAKKRAKDTLNAARRGRGRGRAGKTIGQTKTSIRASTWEMVYSHIGLPREHRNEATNLLEPPVGSQASGIANVPVAQTELPKENILKLDRKRKSSVSSPPLKSSLKSPGQSGVYSEDDSSVSSSPCSHSPMNSEELMNLFVDSNFSATSVLKQLAESRSKGDEKQTDKENNNDKTNNSFVNAAAESNVKKKESGSSMVDVTVFDSSTQMGTFPKNSGTPISNVGNNSYVSDTKTSKPFTGVGKNLAVSSLFGVGPSGSSLNFSSSSLSSISSVKTSSGSGKRPANTLGDSYSGLSHPSSKYSLSSSELTFHDPQSKRARLELSIKRENLNKANEQNRQKSPDCPSSQSPKPPVISVSSPSNSHSSDILTTATKAAATTTTASNVALKNYMQYGYYYSSEDLSRALAKNGSSKSKNTPQTSLYVSASSISTPIMSISSNIHAMPKPQTQNKQPTSKEPASEVLSNSCTWQQSVDPSHKTNDHPNSESISKTSDSSKMAIRPQSSTDFHEIASSSSIEKSTSEKSQCEASALSFTTSTSGATTTTITTSSPTVLTSSDATPLRGTVPDSSSNIQSNGKCYAISYVYPMGTVWYPYVAITPYAVLQKNARKSSGLERCENETEGTSGACDTSSQYIDLASSLRYWQQLSLLYKNQMLVTASANPNILSSTPLTLGQNALGVSSSMASEVPAVLSQQTSMIDSKSERASFSFSSSELSSDITSAFSKQPGQDGSSNSSGPLEKKPLRRASVIVAAKTSNAVSSSRANSEESFENRFSVSTPESDVSSDGTQIKSEPLVIDNCNRLIEEHCQRMNEVLAATRGDYSNNLAASPTPPLLSFIPDSSIAYVNVGNNGSKKTAGNWKDGKSKSSKKKKSNKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQU4</accession>
    <name>A0A6P8IQU4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116303396</name>
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    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Actinia</taxon>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="11">Tentacle</tissue>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="7tm_1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="85"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="97"/>
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            <begin position="139"/>
            <end position="159"/>
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            <end position="299"/>
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    </feature>
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            <begin position="39"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031568780.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37485" checksum="62C9FCB487D5FF5D" modified="2020-12-02" version="1">MSDLQHYETLAFELANRSPQRRVIETSLLCIIALTALLGNSCVLYVFYKTPRLRSVTSIYLKSLALSDVFLSVVVMPTSILTSFYGRNVISDKLGKVVGWMFAQLVFVSLYTTFLIAINRFFXVVKPLLYKKYFKRKTVHLTILVSWLFLFLFVLVLYLSGAVEIDFYPGRMVYFLSFTHKTTTPIPRVITAVSHFILVLFPLTLAGICYWKLYIEFKGHNARVSTTLNVNSKGSTTSLTKEEVQLTRSVLALVCGFIICWIPPSTLFHIAIYIDLPRSLEIVILYTSYMGSALNPILYNIMNQPFRKRCLTLICCRNNEAGLDVQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRI7</accession>
    <name>A0A6P8IRI7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116303979</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116303979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569482.1">
        <property type="nucleotide sequence ID" value="XM_031713622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRI7"/>
    <dbReference type="GeneID" id="116303979"/>
    <dbReference type="KEGG" id="aten:116303979"/>
    <dbReference type="InParanoid" id="A0A6P8IRI7"/>
    <dbReference type="OrthoDB" id="10542736at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569482.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14371" checksum="C6275A73D114064A" modified="2020-12-02" version="1">MVKIRVETRIIHIMNVVVVFDDVKDEKSERGKKFRKNFKNWCLQRLRRRKRRGRSRAWGLRIHRLRKGSVIVEYDLFVNATSQQETQDFIDGLQQEIDSGTIGNYTVDPNHPLGAKITMQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRN2</accession>
    <name>A0A6P8IRN2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISI3</accession>
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        <submittedName>
            <fullName evidence="6">Cysteine-rich hydrophobic domain-containing protein 2-like</fullName>
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        <name evidence="6" type="primary">LOC116304349</name>
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        <name type="scientific">Actinia tenebrosa</name>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="4">
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            <begin position="47"/>
            <end position="136"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="Pfam" id="PF10256"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569934.1"/>
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    </evidence>
    <sequence length="167" mass="19065" checksum="27235084B0384257" modified="2020-12-02" version="1">MANFDAIIDENIETEDVSRVSEDYVPVQKESVVVRGIGHMTIFGLNSKFDPTFPQGLHAKVAPEEFKATIDRVNRVLSKAMPINIRWMLCGCICCCCTLGMSMWPVVCLNKRTKHSLNKILDAENCHLYHKLGLHWHLNKQKCSSSNMKEYVLLIDFIPMTNILRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISZ6</accession>
    <name>A0A6P8ISZ6_ACTTE</name>
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        <submittedName>
            <fullName evidence="16">Transient receptor potential cation channel subfamily A member 1 homolog</fullName>
        </submittedName>
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        <name evidence="16" type="primary">LOC116303922</name>
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        <name type="scientific">Actinia tenebrosa</name>
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            <taxon>Actinia</taxon>
        </lineage>
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="16">Tentacle</tissue>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="component" value="Unplaced"/>
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    </dbReference>
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        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Ank_4"/>
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    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
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    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
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        <property type="match status" value="16"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
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    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="867"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="940"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="977"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="1038"/>
            <end position="1061"/>
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            <begin position="233"/>
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        </location>
    </feature>
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        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
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            <begin position="869"/>
            <end position="1071"/>
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            <begin position="1152"/>
            <end position="1179"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031569405.1"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134524" checksum="E01F3591B82E88F5" modified="2020-12-02" version="1">MSIELVNFIPTDSDPEMTQVEPVQPVKPEKVDVVLPKGATDTSEFSHISLHQAARDGRVDVINHQIFKLGRASSARRYNAINKLDDDRISPLHYAVRYGHLNIVKLLVDNGADINIEGLDGAIPLHYAARFHSVTSKARHQSAISASVEDNVDNLLSENELRPTRAFSEDAISLSGDDGESIIDYLLSLDCDINNRDSYGQTPLHYAANKNNVAGAKKLLQHSGVGVDERDSSSGTPLHAAATVGAELIVKALIDKGADIRAKDYENSTPLHFACSEGHLNVVQLLLAMGEKQHGEEYVSAMLADRNSEKECALHVATDGSFLDIVELLINKGANVRDVRNNNTQPLHLAAISGEIHIAKLLIQHGANIEARNANHETPLHRAAAFNRHSFVHFLIDKGANIESCDKNNFTPLLSAACEGHTLVVTGLLKRGANLNAKNIHNKTAIFMAAEENCVETLKELLNQSTSNSLINESDIYGNTPLHVAAQKGFVVVAELLLNNGAKIDPINEEEYTPLHLAAKYGRTRTVIALLKRDSSIINDEDESSNTPLHLAAMEGHWKCVRELLENGSPVDARNSYLWTPLDCAADKGHVKTAAILLDYDSPVDPKDKTRTTPLHLAARAGHMEMVVLLLSRNADIAMTDHTGRNCLDMAIDHGHKEVAAAIVKAKNWLEAMRNKTLEQGKVTTPMRKLILKLPDVAEIVLNQCVTDNGLPVYHHDYQVDLNYEFLEDVYADWFATTGGSSMGSDTSSLASVQLEKSEFGFQMIDDETMKEEATKQLEKKSSHPLMIMIKRKRETLASHPLVSFLLHNKWRKYGRFVYYLKLLIYVAFLFFLTGYSVITTENPAKTVGNDTIGKTCPAVNIKTKTYIFFVEVGSVVIVVLASWHILMELFQMFYQLQHYLAWENLLEWCTYVSSIVYVATEFKGSDSFGLSKCSEWHQSVGAVSVFSSWXSLLLFIRKFPKLGIYIVMFTDIFYTFTKFSLIFFLFIVAFALSFFMLFSNTDSFQGVGRSLVKTGVMMIGEFEFDDLFGPGVPTLSWALFVIFLIVMTLILMNLLIGLAVDDIKGVQDQATLKRQAMLVDLALDVEKAFPRKMRKRLLERKESFFPNQNKGFLRFLSQPPLTPQEMREALELEKSPIQKLEEQNEVIGKSVKTVKARLKEMQLAQEQLQNMLNAVVQKLEITLEDDAPDEFEEESLFLHNVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT29</accession>
    <name>A0A6P8IT29_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fibropellin-3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116304534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570144.1">
        <property type="nucleotide sequence ID" value="XM_031714284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT29"/>
    <dbReference type="GeneID" id="116304534"/>
    <dbReference type="KEGG" id="aten:116304534"/>
    <dbReference type="InParanoid" id="A0A6P8IT29"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028250185" evidence="8">
        <location>
            <begin position="23"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031570144.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45472" checksum="41047A6725F227D1" modified="2020-12-02" version="1">MNFKAGSLIFVVAVLVTGIATANQSTSKNIKGNKQESSAIIPTIDGKKVGLLHDSKKSAVKSFQWSNLPHKTGKTFAVKNQNLPSQKSGQGLLVRRQFIPNLVRKYQFLQQQYLNQPNDDRQSQAFYSNEETGSERSGPCSAQPCHNDGACMRKKRGFYCSCAPGYIGTHCETRKECDPDTCKNGGTCTEESMGRHLCTCAVGFRGENCEAVSKCHPNPCRNGGECSETEESYNCLCKEGYKGKNCEDINQCDPNPCKNAGTCFEQDGDFYCNCPSMYRGKTCEVISECSTARCINGGTCRDSNTGFGCKCPYGFYGKRCEVTACQPNPCLNGGVCSLFGNQHICRCSHGYSGKHCEVHSPCTQSICLNGGTCVDSMYTNSKYGFACVCPTHFDGILCEKRLPANINQDDEDNSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT86</accession>
    <name>A0A6P8IT86_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570209.1">
        <property type="nucleotide sequence ID" value="XM_031714349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT86"/>
    <dbReference type="GeneID" id="116304587"/>
    <dbReference type="KEGG" id="aten:116304587"/>
    <dbReference type="InParanoid" id="A0A6P8IT86"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="152"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="366"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="480"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="154"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031570209.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="68526" checksum="2FB2CF923506BC8F" modified="2020-12-02" version="1">MPDAKVACRQLGFTKAVGIWYYGRGTVAKPVIRQWGTVCDGSWSSDDLNTAKVVCRQLGFTKTVGYSYRGRGTDLTLHENVQGQWGTVCGDWSDWDMDDAKVACRQLGFTKTVGFWWGGRGTGNSKILLGIRRALCIRKRNQRYNVKQERVTVCNRGAWDMPDAKVACRQLGFTKTVGYWYWGRGTGKVWLYYMRCTGSEASLGSCTHNGWGSVSSSCNSHTYDVGVSLFIDLQSIVNTYFWVMNDATGIVCDVDWISDDRTDKLQYIDLTFNGNIIQVYHSGLWGTVCHRNWNWEINDAKVACRQLGFIKAVGYWYWGRGTGSIVRVYHSGQWGTVCDYYNGYWDMNDAKVACRQLGFTKTVGYWYLGRGTDSGLGSIIQVYHSGQWGTVCDYNLYWDMRDAKVACRQLGYTKAVGYWQLGRGTGKVWLWKMGCSGTETSLGSCTHNRWGNRLRVLTWELYSHGWGTVCINDWDIRDAKVACRQLGFTKPVGYWWYGHGNGKVWLDRMQCSGSETLLESCSHNGWGNVNWDCPTHRYDVGVDPFHLYTAMRMMYVLFCPNGETGQDEAVGAVQRCIDDVRAWMTTGKLLLNDDKTECIVIGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITC6</accession>
    <name>A0A6P8ITC6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine-arginine protein 55-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116304818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570466.1">
        <property type="nucleotide sequence ID" value="XM_031714606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITC6"/>
    <dbReference type="GeneID" id="116304818"/>
    <dbReference type="KEGG" id="aten:116304818"/>
    <dbReference type="InParanoid" id="A0A6P8ITC6"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000028">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031570466.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31661" checksum="609AF88D864FA62F" modified="2020-12-02" version="1">MSRVFIGRLPLDARESDVDRFMRGFGRIRDITLKRGYGFVEFDDYRDAEDAIDDLNGKEILGERVTLEMARGRRGGAGGGGSRGGGGGGRDRGGFSRRRPVWLDKGNQSRSSGSYGPPVRTGYVAVVENLSSRTSWQDLKDYCRKAGKVTYADAHKRRVGEGIVEFSCREDLNAAISKLDDTELGGRRIRIIEDKNRDSSPRRRHSRSLSRSRSRSRSPKRRSRSRSKSRSRSRSPAKRSPRSRSKSPSRSRSRSYSRSPVARSRSRSPPMQNKDDGRDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITJ3</accession>
    <name>A0A6P8ITJ3_ACTTE</name>
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        <submittedName>
            <fullName evidence="7">Dual specificity protein kinase shkB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116304691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031714464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITJ3"/>
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    <dbReference type="KEGG" id="aten:116304691"/>
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        <property type="component" value="Unplaced"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="394"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="220"/>
            <end position="268"/>
        </location>
    </feature>
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            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570324.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="68985" checksum="BCA93B525184B3BE" modified="2020-12-02" version="1">MKGFLWYNKIEGGSTKSRLAGEYPNLYFRSETFRDAILKAVFTSECKAFIMSRLGSESTKYILLRHMMLGLEMQLCERGQIFVEGLHASEVNLPSGFIALYDESSEQQLRPRYESRRNPSPREDMVLAHISWLRPFATHSWTAIKRSREQRRNAHSLENYVRSLENKLAAQHQAWKNERVLLAQLEIQEKEIDLVNSEQISDGFETELMIQQEINNELKFNELQRKLARKQEDIKVAEHQFKRSEQRVQELEVTLAEEQNAHEQTKRSLKLKSEKVHELEINLASTPKALEEKENELIRVRQIPAVFEDKLVTEQETTKEVEKHHEGTVDKSNELQRKLACEQKAKEETEKRLEICQEKSKELETTLAATQKLVKKKQEPENECEWTLNREEIQITEEKLGSGTFGTVYKGMFRGTQVAVKQVSVKPKITEYNIGNFRREMKIASRCRHPCMLQFIGATSDDQSPLLLTELLDTSLKMVLLDRALDLVEIITIARDVAKGLNYLHLTRPHPIVHRDISSGSVLLWKHGQSWRGKISDYGNAVLMNYAKTGSGGAILYLAPEMNNKRFSPKCIRVYWKKSNTVMPRAFSDDEASCLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITQ1</accession>
    <name>A0A6P8ITQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116304085</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="KEGG" id="aten:116304085"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047:SF7">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569600.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="82569" checksum="4E1A7F41139D98BC" modified="2020-12-02" version="1">MADFDEDDTIRNKCRNVKFKIFRLFRIEINPVVTFVSAILIWGFVIYCLRWTGQAGEVLPTWKNWITQTWTWLYIGNQDAWAVFILYLLFSKYGKLKLGKPNDKPEYXDATYFTMLFAAGIGVGLFYFGVAEPIYHYHPSHKTDYGNRYQGRYSDNQRAQDALNVTIFHWGIHAWVVYALVGLILGYLSHCKGMPMTMRSCFHPLLGDKIFGTLGDFIDILAVVCTMLGVCTSLGLGVVQLNSGFNRMNNNITQSKETQVIIIWCITALATASVISGLKLGIRRLSELCFSIGMLLWFVVFFYDDTWYILNVSVQTLGYYMQQLVQLGFHTDAFAQPGDAPDKKQAPQWMNDWTIFYWGWWVAWSPFVGTFIARISRGRTIREFIMYTLTLPTIYSLLWFSVFGGAGLRMERAAANANITCNSPLGGWNSTESLXGLYRLSCRPSVNMWFDLMDQYGGLGDFLSGMSIVGLILYFVTSSDSGSLVIDSLSANGHPDPPVLQRIFWALTEGATATALLWTGGTKALSALQAVSIXSGLFLTVLLNFICVALWRILKTDVGDLDPNGPQFTMGLLDIFYXPSCKLFARLVVAIFAPWWPLGNATGKLYGSNRYVSMVSLAIPFYGWIILEILQVLEPGLAYVGWAVLFGFFALATGTRAYMREKYNILGNLAEDFFSVMLVYPLAALQMDEQMRGGQFHHDEKFNAAETNMALDEMEKNPDALNGTYKRKSSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX86</accession>
    <name>A0A6P8IX86_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116305909</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571769.1">
        <property type="nucleotide sequence ID" value="XM_031715909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305909"/>
    <dbReference type="KEGG" id="aten:116305909"/>
    <dbReference type="InParanoid" id="A0A6P8IX86"/>
    <dbReference type="OrthoDB" id="10285285at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027917343" evidence="3">
        <location>
            <begin position="20"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031571769.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="77700" checksum="B2AD9DA0AA451E44" modified="2020-12-02" version="1">MFLVLVLVVFIVVSQPCFAIEMSVTRSLQDNFSVSNCSLCAKFNQATCFGEGVCQCPTNASTFFIYKQRCDSFSSLINDKDCLSWSSDKNHLEVIDLTSSSSSPIFTTLDSCSVPLGRTFEYLGRRGHWITHRLQGDGTVFGIERKPTPPRRMSLQILKNNDLVSFAGRIIRVGLLCRGSEGEVNRCLILKAKGTISVKGSISPSQGSVPTIQHGDISTTIAATSKRITKTETKEPTTPNIHYIGPQSKPRFTPTPSNSTVITQAHINGAVSVDKTNKKGDAVVVAIISVLGAIACVLVIGALFAWFVIKYYKGFRQQDQRNAPQSIVMGNSQDLQNVIPMASMTTAGRLPEPVYSELPDVVESANRNRSGGPTDITIPIDNQKDFFIIRNPMQYNTLPRARKLTDPLPATPIPDRSRTPDFRLTHRTTSTADPSVTKTAQFLSEISKTLHAPVFQDLTRRNRSFTDADSDGVFFENFPAKVLVVNMVDGREENSKPINKSAQSIYEDLSEANKQSRISVYEPLEKATLQPPDVRKTTLERINDTKENANQQIVFSEEYSAVPEYYVLEPSIEHETHGHENSPTNDQIGXEKLYLDNEDNSGTLPVGADLKGPYSSPMTGHLVQKGPNEEWDQGFSNKGLEHDDKSIXDKKSFQASEKIFKDNQSNGLSESKDGCVSHGLSHRRGRTSEEIILRPRAKSSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYJ7</accession>
    <name>A0A6P8IYJ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572244.1">
        <property type="nucleotide sequence ID" value="XM_031716384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYJ7"/>
    <dbReference type="GeneID" id="116306344"/>
    <dbReference type="KEGG" id="aten:116306344"/>
    <dbReference type="InParanoid" id="A0A6P8IYJ7"/>
    <dbReference type="OrthoDB" id="5951194at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="34"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572244.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21332" checksum="80B7822CE57EA1B0" modified="2020-12-02" version="1">MAATESESRTPLQTSRKRRHIGKRNSQTFLSSGCTINLNPIGVSNSNIIPDDRFTATSYLVTSAKPHYARLNGMYSAWIPNTNVDPNDCLQIDLGEVFVIRAVATQGHPKWPFCTKEYKISTSIDSNTWTMYQSSGKVKLFHGNTDENAVKTNVLDSPVDARFIRFIPTKYKVWKALRVEVYGRKKLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0W6</accession>
    <name>A0A6P8J0W6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">von Willebrand factor A domain-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573152.1">
        <property type="nucleotide sequence ID" value="XM_031717292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0W6"/>
    <dbReference type="FunCoup" id="A0A6P8J0W6">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="116307139"/>
    <dbReference type="KEGG" id="aten:116307139"/>
    <dbReference type="InParanoid" id="A0A6P8J0W6"/>
    <dbReference type="OrthoDB" id="5971315at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056475">
        <property type="entry name" value="GBD_Hemicentin/VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057615">
        <property type="entry name" value="Ig_VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23560">
        <property type="entry name" value="GBD_Hemicentin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23619">
        <property type="entry name" value="Ig_VWA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027560359" evidence="6">
        <location>
            <begin position="26"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="187"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031573152.1"/>
        </source>
    </evidence>
    <sequence length="682" mass="75602" checksum="A1A64EDE7FB347EF" modified="2020-12-02" version="1">MVMKTLAYLLVLSLALVFRFHLADGFTFPSILDDARQAMMKFSKPATTTTTTPTKPTVPGGGWLGGGRRRRRYVRPRPPSRTKPSNSFLEVLSKVEKSVLEAQASGNKHFLSRAKMDTLINNIKIALKKRSFLFARETLGKALYKALTTRSGPRVKRSASSAKQFLDKLQKEIGQTKFSELLGVEDYKTLVFAIDDTGSMGGEIRAVKDISSAIVRTQAGKKTVNYILSVFNDPTTGPVIFKDSGTEFIKELQKLRAHGGGDYPELTFKGMLDAMEEGPREGSPMYVFTDATAKDHTKDNINTLIGAARDFGVSINFFTTSAASSFAPFVQVARETCGMILRLVGSSEIRKLESITKLSLRNSGVCMTGGDDGGFFGKKRAVSRSKVILVDDSVKNMIISVSTQNSNPVIVLRDPSGRRFTGRKISLYRAAIYELINPTPGRWTLSVAASAGKYHYLVRGSSDSNIDFDYYFVMLPTRKGRYPIPINQPLAGQRANAIITVAGAERIQRNRLSVELIDSRNGRVLTTVAMTPRSSSKVHFVVSFTPPSTPFKFRMKGRTKAGHGFERSSRKTIRATTALIRVYRAKDGQLTIPRGRRMYVILLIFNVGPTETFDVSVNDPKRYATTRRKQRVQVYKNRSRRFILWFTAPSSATPGKGYPVAVTIKGRKSRVETGQILNLIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1C3</accession>
    <name>A0A6P8J1C3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116307559</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031573706.1">
        <property type="nucleotide sequence ID" value="XM_031717846.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J1C3">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="GeneID" id="116307559"/>
    <dbReference type="KEGG" id="aten:116307559"/>
    <dbReference type="InParanoid" id="A0A6P8J1C3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18078">
        <property type="entry name" value="DEXXQc_Mov10L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000864">
        <property type="entry name" value="Mov10-like RISC complex RNA helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025223">
        <property type="entry name" value="S1-like_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14444">
        <property type="entry name" value="S1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="680"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031573706.1"/>
        </source>
    </evidence>
    <sequence length="1438" mass="160510" checksum="2DF1141EE769AD22" modified="2020-12-02" version="1">MFNIISKFTGYVFGSDEDGNSSIAKNKDKSPQNPKDNSSKKVSNSVKKDEDLLRKSCYGKVSRLYDGAGVIDDEVYFTFDVIIGGSRLEVGNEVHFEAKRENNTSGWKATRVRRFKEWGTFQENGVIENAIGFATALKGDILELNNGMSFNMSVLKHQPYSPCKGDWVKVELERFTDDSLEIRGVKPLREKNLSGKVNSVFPGYGYINEEVYFTFGACVRGYRPCRGDDVQVTAVESVQGKCKWRAVNVEPKKIPKQNSPCVGNLQQFLGNKMAELLSDKHGIVISGNLDFGDIAIGQSRTLCINIKNTDDKEHTFKSWSFVRADPQFEIQLLSMENHSPVPQNSKRKTSESATRMLYCGMQIPSQETRNLNIKFTAKNLGRVKQLVVLAFDCGEIGRHVTSNVVDDHQDMLAPVTPYQRNRNRGREAWDRFVESGSRERWIVPGERPTRKTKLIFPIKLKMYSVPRDIRNCIMDDRDLTALVPVLTEPLTMQNHAAKFGTLLYAEELQMELDMREFDLQNVTMDLYREYLSLRVPGLAEGRPSLLIGDTVVASLTDGVYDAPKYEGYVHEVRKDDILLKFNEEFHKNFGLQSCDVTFYFNRSTIRRAHQAVEFAAQLGPEVMFPRKLEPKLPVVNLCLGSSNAEDTAETSNKEEDFLYNSNLNERQRAAVSRILSGQSRPTPYILFGPPGTGKTVTLVEAILQAFHRIPSSRIIACAPSNSAADLLAVRLQSSGFIQEGDMVRLNAVQRAQDIPETIVPYCLDTDRLTLAAHYRIIICTCSTSGQLFSLGLRAGHFTHVFVDEAGQATEPDCLIPMGLAAGGEGQIILAGDPHQLGPVLRSTLALEYGLNISLLERLMSRPLYTRDEARFIDHGCYDPLLVTKLVNNYRSHPVLLHLPSALFYHNELRVHADEKMRERFGEFEMLPKKGAPLVFHGVKGEDLREGNSPSWFNPAEAVQIIRYIQGLKKSEACSIKPTDIGIISPYKKQVEKIRLLLRRVGIDDVKVGSVEEFQGQERPVIIISTVRSDQSYIGSDVDHSIGFLSNPKRFNVAITRAQALLIVIGNPHVLCQDPYWCSLVQYCVMNDVYTGCDLPDLDSELYQEEFHYALNVISQIASNSESGNHGNDEETITDEVCATLKVDASASVSSSVTASNNTQQITTMHLSDKNLLKKDSQISEQGKHAANKNQNYENLVEHSLNELNSSASEKLENTFELSLVAKQHQSCVKTRDKESSCYDDEPDPRGYRTSSACLFEDAINGTSNGVYSENVLKATTGSPTDIGGFSRGLPGIEKTMSQQTDIFASKASLLQSQENQVYHKVGGNVTTKNDEGNGRIVITEGQKSNSKGDQTCKVPDSSCHGLTNFNNTLTSSNIHRENQVMKNVDSSNLQLKVDFTTSELGLPVDDPLVCVHVMNTSLPPNDASDEEDLEEFFIKPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1S8</accession>
    <name>A0A6P8J1S8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iodothyronine deiodinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the iodothyronine deiodinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573552.1">
        <property type="nucleotide sequence ID" value="XM_031717692.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J1S8">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="GeneID" id="116307435"/>
    <dbReference type="KEGG" id="aten:116307435"/>
    <dbReference type="InParanoid" id="A0A6P8J1S8"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004800">
        <property type="term" value="F:thyroxine 5'-deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042403">
        <property type="term" value="P:thyroid hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000643">
        <property type="entry name" value="Iodothyronine_deiodinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008261">
        <property type="entry name" value="Iodothyronine_deiodinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781">
        <property type="entry name" value="IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781:SF22">
        <property type="entry name" value="TYPE I IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00837">
        <property type="entry name" value="T4_deiodinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001330">
        <property type="entry name" value="IOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01205">
        <property type="entry name" value="T4_DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 8" id="KW-0893">Thyroid hormones biosynthesis</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573552.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31882" checksum="BEE9D5FA5E2308EC" modified="2020-12-02" version="1">MGASSKVLILYYAISVILLLVFGILKLLQKICWMEGAITGLIKMVSTIDMPKEDYWENLFGWEMFKAQQKCLQRDLMKEAQKGRPAPNPHLVSLDGSKYFQLLDFARGSRPLVVNFGSCTCPVFMERLQQFGEIVEEFSPIADFLTVYIEEAHPIDEWKLEGNIEILQHRTQQERCHAARTLLDLGKVHSESPLVVDTMENVANNAFGALPIRLVVIQXGQVKYTGGIGPTFYETADIRQWLSVYRKKKHPPEGVKKAPSLFVLFPFLILFPNSNAVIISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2C8</accession>
    <name>A0A6P8J2C8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RYamide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116306327</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572223.1">
        <property type="nucleotide sequence ID" value="XM_031716363.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306327"/>
    <dbReference type="KEGG" id="aten:116306327"/>
    <dbReference type="InParanoid" id="A0A6P8J2C8"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031572223.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39552" checksum="0D9D0537E61DA0ED" modified="2020-12-02" version="1">MLVNDSXVNNTWNSTSTSQVHSXNNGTASLVILSIIIGLGIIGNSFVVMVVSMIPAMRTTTNFLLLNVAVADIVTLLLTAIHVALRSVVVASNFMCKVIAPNTLSNVALLATGLTLTVLSVERYNALVKPMRVSRRLTTDNVLYVIIVIWVVSMAMALPMLIYIKYDPQSPQMCTPGQNLNDLLISVGCIVFSMTIIPFLVIAFSYSQIISGLYFSNTIWNSNNPGTLPEDLVAKRKLVKLLVTVTVIFFIAFVPYGVLQILNFSLHEKISKQQLQNLKKLTVVIKYLMPLHSSINPLLYTLQSQNYRDGFVAVAKKIFCKGGGNVREGGELSRAEERSCNHYYRDSAVFFSKDHVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2T6</accession>
    <name>A0A6P8J2T6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116307761</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573927.1">
        <property type="nucleotide sequence ID" value="XM_031718067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2T6"/>
    <dbReference type="GeneID" id="116307761"/>
    <dbReference type="KEGG" id="aten:116307761"/>
    <dbReference type="InParanoid" id="A0A6P8J2T6"/>
    <dbReference type="OrthoDB" id="5972148at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573927.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27488" checksum="21D48C4EDF5BF1AB" modified="2020-12-02" version="1">MASNQQKGDESIPLEANETPEDCAKRLSRRLSEYEAASIDIEGRANQLRKERDAERALNQKLHKEVEKLSNQLLHERTTNALLAKKVKMLENKDDDEVKTDPDNMDASSIPSDVFSDKDLALKVKELQKIIEERIKEEEKKQPEDEADIHNKMAALVMLHQSTQNYLEEKNDNEDSEDDSVETLNTVETLVEGLKNTHEYLEEKKKKGKPQVSTWMRIFVCLGPIFLSALCYLAFASVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J323</accession>
    <name>A0A6P8J323_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="10">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116307858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>thiamine + UTP = thiamine diphosphate + UMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79423"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:79424"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031574037.1">
        <property type="nucleotide sequence ID" value="XM_031718177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J323"/>
    <dbReference type="FunCoup" id="A0A6P8J323">
        <property type="interactions" value="817"/>
    </dbReference>
    <dbReference type="GeneID" id="116307858"/>
    <dbReference type="KEGG" id="aten:116307858"/>
    <dbReference type="InParanoid" id="A0A6P8J323"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10240:FF:000006">
        <property type="entry name" value="Thiamin pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000002">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="11">
        <location>
            <begin position="166"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574037.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27888" checksum="6DD5BCF6B50A5F6F" modified="2020-12-02" version="1">MMEPLKSLSSANIKEKIALLILNCPLEVLEKKLDVLWRNAAVKIAVDGSANHLYSLIQQNQEFLPDSITGDFDSARKEVLEFFKDKGVEIIHTPDQDHTDFTKGLKYLTSKPNAEYDVIVVLGGVMESRMDHTFANFHTLYLAAEMTDKNVFLIIDDSINILLQPGKHTIRVDSGLEGDWCGTIPLGQPCKSITTTGLKWNLDHESLSFSSMISTSNTWAEGSTAVTIDTSDPVLWSMGIKMPKVGNGEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3C6</accession>
    <name>A0A6P8J3C6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein DDB_G0271670-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572518.1">
        <property type="nucleotide sequence ID" value="XM_031716658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3C6"/>
    <dbReference type="GeneID" id="116306582"/>
    <dbReference type="KEGG" id="aten:116306582"/>
    <dbReference type="InParanoid" id="A0A6P8J3C6"/>
    <dbReference type="OrthoDB" id="10545226at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027754526" evidence="3">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572518.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="45910" checksum="1DA920A34B69A072" modified="2020-12-02" version="1">MSQVFISVCALVFCFLLIEVRATNTTTSNSSAPICNDNSTVNGSSANMTGNTTACSPSISYSLTPSPSPTPTATAGAQATTTTAGSGTPTTTTSSTTSTPGGGATPTTAGASNGTTSTTAGASNGTTSTTTGASNGTTSTTTGSGGSTASNTAGSGTTTASTTTGAAGSTASNTAGSVDSTASTTAGAGGSTTSTTAGSGSSTASTTAVSGGSTTATTTGGDGGTTAATSAGAIQPTTTSSSSSGSTQTPGGSNSTTQSPTGEMPTTKAKLPYAKATISARLFGIFTQDLKNNNSDGFKSKAKECEDAICPVITAKFKNGSVKECRVKEFINGSIIAVMIVTVDKEIASIPPNTSYNNIITNALLEANSTGTLKGLNLYSVNVNSEVPTRPPPPPPAPEDDDDGLEGWQIALIVIFVLILICVIVFVVFLVMYKKKTEPAKEMVDRGCNMGASNPAMYGDAEDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J555</accession>
    <name>A0A6P8J555_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein rolling stone-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572605.1">
        <property type="nucleotide sequence ID" value="XM_031716745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J555"/>
    <dbReference type="GeneID" id="116306667"/>
    <dbReference type="KEGG" id="aten:116306667"/>
    <dbReference type="InParanoid" id="A0A6P8J555"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049352">
        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF49">
        <property type="entry name" value="HEADBUTT, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572605.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="33044" checksum="0C9585ACDF500F9F" modified="2020-12-02" version="1">MCLKLSDVNPKKLYPRYPFVRAFTTSPCLPTYAFVLYRLIVGLYCLAWLIFSGYNYNSKWLLYISNWIFVFIAAHFIFGSILSMSYGLSDEAQYYDTSTRWGSEPFIEGFSGYDEDKESTGKEVWVDEKIEDKLGLCHKLLWIIFTIASVGALQITLIYWSIFYEDQEINGVNITFLIFNSVFITIELLLSNLPVVLLHFFYSHIVQSIYILFTVLYWAFGGTDAKGHPYIYKALDYENEPDWAVIFAFLYVVIFQILAHIYCFSLFHLRKWLVRKFYLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J862</accession>
    <name>A0A6P8J862_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116307802</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031573978.1">
        <property type="nucleotide sequence ID" value="XM_031718118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J862"/>
    <dbReference type="FunCoup" id="A0A6P8J862">
        <property type="interactions" value="1568"/>
    </dbReference>
    <dbReference type="GeneID" id="116307802"/>
    <dbReference type="KEGG" id="aten:116307802"/>
    <dbReference type="InParanoid" id="A0A6P8J862"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07838">
        <property type="entry name" value="STKc_CDK4_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000205">
        <property type="entry name" value="Cyclin-dependent kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF472">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="5"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031573978.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35565" checksum="124F020442E8FA05" modified="2020-12-02" version="1">MATKYEEVAEIGTGAFGTVYKARDLLNDGQFVALKRVRIINTEDGIPLSTIREIALLKQIDHCAHPNVVRLLDIFHIPMVLLKETHLNLVFEHVEQDLAAYIDECPSPGISEWKAKDISYQLLNGVDFLHTHRIVHRDLKPQNILITKEGQVKIADFGLARVYKDAMALTSVVVTLWYRAPEVLLQSSYATAVDIWSVACIMAELYNRTPLFEGKSEMNQLVKIFSVIGLPPQADWPQGVSIPWLSFHKYTPEPLENLIPEMCPEGFDLMKKMLVFNSKSRPTACESMQHPYFQELQENDKENSQSNSNTKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JGG6</accession>
    <name>A0A6P8JGG6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116308975</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575360.1">
        <property type="nucleotide sequence ID" value="XM_031719500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JGG6"/>
    <dbReference type="GeneID" id="116308975"/>
    <dbReference type="KEGG" id="aten:116308975"/>
    <dbReference type="InParanoid" id="A0A6P8JGG6"/>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="54"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="261"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031575360.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="54389" checksum="5580639657EB2FC6" modified="2020-12-02" version="1">MYVLPVFTWLYSLNYLSEKTFGLIQKEGETSKHVNATGASYSIAAKIIREKMKLKNYDKWVRPNDTGGAVEVFVEMKIMAFGKVREDDMDFTLDVFFRQWWTDERLAHGVDKIFNMAADPKKYFWTPDTYFVNVKSSNFHKVTRENMRLMIWPDGKIYYSTRITLTASCEMNLSMFPMDTQVCLLKIESYAYTIEDVVYNWRVRGKEDSSIEVYAAEMAQFDMKSIQTSKRESSNSKGSFDSLHIKFKFKRRSSYFFVQHYIPSSFIVFISWLSFWINKNAVPARVSLTVTCILSTMVLFESINSSLPRISYLKAIDYYLIVSFFFILASMVEYCFVLNIMEKSAEMSRKNSLQVKEELDRVEYDYFRERFPGVSRLKRDANLTNGCPSSTINMNTIPRPIPTSKENRHQQINYDLDDFLPAECLRSGKECVHFVDHYSRKVFPLLYILFNIGYWSYFLPKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZJ6</accession>
    <name>A0A6P8GZJ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-aminoadipic semialdehyde synthase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116286530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548928.1">
        <property type="nucleotide sequence ID" value="XM_031693068.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8GZJ6">
        <property type="interactions" value="1806"/>
    </dbReference>
    <dbReference type="GeneID" id="116286530"/>
    <dbReference type="KEGG" id="aten:116286530"/>
    <dbReference type="InParanoid" id="A0A6P8GZJ6"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="218"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031548928.1"/>
        </source>
    </evidence>
    <sequence length="941" mass="104762" checksum="27EE62BE127A0911" modified="2020-12-02" version="1">MWRVSSVKTGRRCLLTQHILRCASSRTFCSSHGEKVMAIRREDINVWERRSPISPAHVSELVNRGIKVLVQPSTRRAYTMDEYERAGAIITEDLSPASLIIGVKAVPVDLLLPNKTYAFFSHTIKAQEANMPLLDAMLDKNIRIVDYEKMMDDTGQRVCAFGKFAGVGGMINILHGLGLRLLALGHHTPFMYMGATHNYKSSRAAKLAAYELGEDIKSGKLPKHFGALSFVFTGSGNVSQGAQEIFKELPHMYVHPHDLKKAVEGGDHRKLIGTVVSREDYLVPKAGGKFDAEEYEAHPERYRSNFAEVVAPYMSCLVNGTYWAPGIPRLLTYDDAKNLLKPMARTSAYDGCPNLPHRLLAICDISADTAGSLEFMTXCTTIEYPFHLYDIKNETSQIGMAGDGVLICSIDNLPAQLPREATDYFGKLLLPWIPEMIDSHATDPFEKQTHLSNTIKNAIITSNGELTPNFKYIADLRKRMEEAKTRALGPNVSVPISKRVLVLGCGMTAGPVIEYLTKDKTVAVTVASDIISEAEALASKYVNTTPVILNAQHSPDKLEEMIKNHDVVVSMVPYELHDIVAKKCIKQKKNLLTSSYSHVLDPDIHQAAVDANISIGMELGLDPGIDHMLAMECFDDVKEEGGKITSFLSYCGGLPAPECADNPLRYKFSWNPRAGLMSIMHGAKYLWYGKTVEVAPGERLLEEIKPTDQFPGFRLEAYPNRDSTVYRERYNIQTADTVVRGTLRYEGFSTAASALYKMGFYDLRESPVFELAHEVPFFKLVAKMMGRPDAGMKELLSLIHDRVGRDDARVQAIHDLGLLSEEPVVPQKNAFDTLAHFLKTKLAYKEGERDLVLLRHEIGIEWPDKKMETRSITMTSYGDPNGYSAMARTVGIPLAIATKFVMDGDIKAAGVFTPVRRQIYKPLVKKLRVEGIKSQSSSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0A4</accession>
    <name>A0A6P8H0A4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">5-hydroxytryptamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549854.1">
        <property type="nucleotide sequence ID" value="XM_031693994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0A4"/>
    <dbReference type="FunCoup" id="A0A6P8H0A4">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="GeneID" id="116287329"/>
    <dbReference type="KEGG" id="aten:116287329"/>
    <dbReference type="InParanoid" id="A0A6P8H0A4"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="51"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031549854.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37968" checksum="674956F5FA0E92D9" modified="2020-12-02" version="1">MNNTSLGNVALPIKCLRSVAEEWTNYHYLNPTLVTAIAVLSLILGVLSTLANGLVLAAVFKTPSLRTKTNFFLTSLALTDLSMGLFICPLFFFGALKWPYHVRFPVFGMVLDFLIMQTLIGSTLNLCAISYDRHIAVKSPLLYTVIMTDKKCVSIITTIWVASTGLSALSFMDSSYEERPTVYIIPALAVPVPSITFMSYCYWKIYKVVLRQKKQIKANSPSAFVNNDDTTVVQNRGNDSARLKKERKATTTVAMIVGTFILCWLPNTLVSILHFFITKSYKCNAYTFGEFWLLSLPISFLNSLLDPLIYVLRNREFKFAIKALFLRSSTRISHLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0A6</accession>
    <name>A0A6P8H0A6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116286445</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548821.1">
        <property type="nucleotide sequence ID" value="XM_031692961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0A6"/>
    <dbReference type="GeneID" id="116286445"/>
    <dbReference type="KEGG" id="aten:116286445"/>
    <dbReference type="InParanoid" id="A0A6P8H0A6"/>
    <dbReference type="OrthoDB" id="5981056at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031548821.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47482" checksum="ADB1DD7B79DE3147" modified="2020-12-02" version="1">MNIVDENGKLQEDENSLWLPFEHYEDQNDTKNFHCTSIIWKHDYATYTELISHSFPWPKPDSKEVGHNHSEFSDKSSTCKCAAKELCYEQCISYSKFFIDQRSKEYWDKLLQSSRKKKKVLNKQKSIWNQSYVNVLPLNKLCINRQEAPNDDIKESTLNDGSSFSKNEVKCNFVLTSDESESEDSGDVVDESDPMYSRFAVIRNSFHTSEDGIVFYCQKELDIYKAKMAEMEDLLERELKQIKYQHDQLRAKRAEQRKLLSGGADSSNDHDSHEEEPTEKDALNSDNSRQGTALKQERKSAIFSSIHDVFSYARTGIQGMFVKTSPNSARKVKTNDASDSEGSDDEEDTKINDSTSSIKHSAPLLDNHDEFTRQMTSEGGLKYESSDKSVQQLSYQNLPPPLSLNSLQDKRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3M8</accession>
    <name>A0A6P8H3M8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550066.1">
        <property type="nucleotide sequence ID" value="XM_031694206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287523"/>
    <dbReference type="KEGG" id="aten:116287523"/>
    <dbReference type="InParanoid" id="A0A6P8H3M8"/>
    <dbReference type="OrthoDB" id="5954753at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="385"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550066.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="77181" checksum="F1EEC05A9ACD69B5" modified="2020-12-02" version="1">MPTQRNKEYDDAHSFFTEAKTIAREPEDNHKVSYLGIRINEISEIVGMSEGHSELVSPLKEFPDVVQENESLFHSFFRFLHLKANYKYEEAISCLEDFMAHGKNSINEDEYRELLWTCKQNISELHVLLKDYDKGIQYQQEALDVARKQGSKANQAKTHFSLGKVYYKLKKFENAEXSFKESLTCYELIFVGLKQNDRFKIAFIDKYKETFKLLLKVLIERNKKEEALSLSDHYRAKALKDLLVSNYGMKKEQTADEDLQYADVQSLVSSSDYTLLFYSTCFDELSKVGFSVQRFKYCDTCVDKLVDERFEDMKVPRQVIHCEDRSLDNMHYSEENKNPKDDELTQLLIQQREKRLSRYCRSTCVCRENPSENCDESRLTSGLEILYQKLINNIKSLNKQDEMVIIPEGPWYRLPFAALRDPDTGQYLSERMRIRMAPSMASLKFLQEYPVKHHSRNEALIIGNPIVGEVMLDRAPFKFAPLPGAEKEADEIALILKVTSLLGTKATKPVVIKRLQEGASVVHIAAHGSLEKATIVLAPSPEIRKTKIPDEKDYMLTMADVQQTQVRAQLVVLSCCYSGRGEIKAEGVVGMCRAFLASGARAVVGSLWAINDDATLMFMKKFYKYLKDGKNASTSLNLTMKDMKRTPQYSEPKYWAPFFLMGDDVTIQFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3N5</accession>
    <name>A0A6P8H3N5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550076.1">
        <property type="nucleotide sequence ID" value="XM_031694216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287533"/>
    <dbReference type="KEGG" id="aten:116287533"/>
    <dbReference type="InParanoid" id="A0A6P8H3N5"/>
    <dbReference type="OrthoDB" id="5995398at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028012554" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550076.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13050" checksum="6B7AED23651A532E" modified="2020-12-02" version="1">MESTRTQVIITAVLLVILAAFSLAQPLXKPDNNDVAPGNQTSASSSQQGQIITVDATAPNKAMFRKTRNGNLCVERRITRVFYFRYAVTGIAVCHKGCTAKTKALRLGNGRWVVVNSDCX</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3V2</accession>
    <name>A0A6P8H3V2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel subfamily K member 18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550131.1">
        <property type="nucleotide sequence ID" value="XM_031694271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3V2"/>
    <dbReference type="GeneID" id="116287581"/>
    <dbReference type="KEGG" id="aten:116287581"/>
    <dbReference type="InParanoid" id="A0A6P8H3V2"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="244"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550131.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37066" checksum="DCC04B1FD58B8FDB" modified="2020-12-02" version="1">MASSELTDQEKTQRNEANDNTEPNEGAENIINLVAARKLCDLKPKFMYNCLLVGVLISYGLAGGFVFKTFEAAPIDFEEKTEAIKATPSAEDLLNELLKTQNKNTEPFDEEWRRFAIAKIDEFVDVKTKAGQVELNPVEWSFADSWLFACTIFTTIGYGNIAPLSIKGRFFCMLFATIGIPLFSVVAGSLASFIMDLTRTLHAEYHRRKRRAQSAQQKKDDTSSPDVEGEVPELEITLKHVAMVCFGYLCLGSMFFSLGEGWSLFESFYYCFITLSTVGLGDYVPGHVHHTSLFGVYILVGLVLLIMLFGALEEVITKHCQKIKDKLKVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4K9</accession>
    <name>A0A6P8H4K9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division cycle protein 123 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550366.1">
        <property type="nucleotide sequence ID" value="XM_031694506.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H4K9">
        <property type="interactions" value="1683"/>
    </dbReference>
    <dbReference type="GeneID" id="116287809"/>
    <dbReference type="KEGG" id="aten:116287809"/>
    <dbReference type="InParanoid" id="A0A6P8H4K9"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550366.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38357" checksum="2A114ACCC5320B07" modified="2020-12-02" version="1">MKQQHVRNCSFSTWYPRFKNVTIRSRVIPLSKDFIDYLNADGVVLPGEPCSHTRNSDDESDSEEWKSREEDPDQETAQAPEFNEIETKIKEAVSDLGGSVFPKLNWSAPRDASWISHNGTLKCKSVNEIYLLLKSSDVIAEQLTNPFEGCEDSQSENDMGYELVLRKWMDIYPGMEFRCFVKDRELVGISQRDISSFYPFIKENQDDVITDILLXFENKIAEAFPDSCYVFDVYRYADQKVLLLDVSPFGPPTNPLLFTWSEFTEDELEQLQDVEYPVFRAINSEVGIQPSPFSSSHLPKDFRDLAAGEDINKLVDFLNVNQLIRRPEDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4Z7</accession>
    <name>A0A6P8H4Z7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ceramide kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550608.1">
        <property type="nucleotide sequence ID" value="XM_031694748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4Z7"/>
    <dbReference type="FunCoup" id="A0A6P8H4Z7">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="GeneID" id="116288028"/>
    <dbReference type="KEGG" id="aten:116288028"/>
    <dbReference type="InParanoid" id="A0A6P8H4Z7"/>
    <dbReference type="OrthoDB" id="530923at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045363">
        <property type="entry name" value="CERK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057465">
        <property type="entry name" value="CERK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF111">
        <property type="entry name" value="CERAMIDE KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19280">
        <property type="entry name" value="CERK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25382">
        <property type="entry name" value="PH_CERK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="128"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550608.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="61708" checksum="AC7B38FAA09DFF36" modified="2020-12-02" version="1">MATGGEGSSLFHSVLHHNSKSVNVFITPKTFYWCSEGSEEHPYGNVPPRHSIPLTEIFAVSPNKQVTSQNEDGDIEMSMLKSTSFIIHAIKRMKHHKWKTKRLLFDCQLSSECYEWIQRIQELLDGMQRPRRLLIFINPVGGKKLAGKIYKEKVQPLFDLANIKTEIIVTERANHAKDYLELESLDKLDGIITVGGDGMFHEILNGLIRRTQTDNNVDTTKPDFEPVQPSLTVGVIPAGSTDAIAYCTNGINDPVTSALHIIIGDVHPLDVCSVKHKTEVQRYSVSMAAYGFFGDVLQDSEKLRWMGPKRYDYSGFKKFFINKGYDGSVSFLQDDSLEAHPLDKSRCRTGCYICNPVNKDPFLQETPDETDKQTESDSSSLQWKTIDGRFISVIGVNMSCACAKSPEGLSPSAHLADGYMDLILVKHTSRLQYLRHMLSLANRSNHFNFNFVEVFRVKEFHFKPSQSAEPNDDETDEAAIPARDNDQEILAGPAKKSRGNASKSTWNVDGEPVEEPGVHVRVHCQLIKIFARGIEECSDTPSCALCYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5L7</accession>
    <name>A0A6P8H5L7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116288153 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550756.1">
        <property type="nucleotide sequence ID" value="XM_031694896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5L7"/>
    <dbReference type="GeneID" id="116288153"/>
    <dbReference type="KEGG" id="aten:116288153"/>
    <dbReference type="InParanoid" id="A0A6P8H5L7"/>
    <dbReference type="OrthoDB" id="5917794at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028230123" evidence="5">
        <location>
            <begin position="23"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="258"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="371"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550756.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="80189" checksum="B0CFA7A17FA4EE79" modified="2020-12-02" version="1">MVCAFSYPAILILLLQNGYITGLTSWPDGKYGLLKPTTGCPEEWTDKEWKKTRVKYKYGNNRWSYRLEYRGLTDRGFIFQTTDDNYPNIEASQTLNMEEYVDPDFVLRYFCVKRTEVKPSSIKWPPGQYCIYERGKQPGGRIRMYDMDYSYRHSTKYVKDFTDNWYHSINLHFSCQTSGNEKIPISLPITKPFYLLPYGSRDCQQVEWMVATTEWIKYHTGNYKDRSYQKSGTAVPFYEIGDIKNKGITMYYCYYESCNYTLTNTTGVFQSPGFPGEYPDGQLCSWRIMVPDNHTLHVHFTNFSLYEYDKDCLQLYENNSRIFKHRQAFFGQQPPFTITATSDVMFVFRSDEENNSTGFRANYTMFKTPERTTTAPPKPPTTTTLPTTTTQSTTKLITTQPTTTKQPTTKRPSTTEATTTFPTTPNINSTANETVQCIPITTKNKSYNKDNIHSLKKTCFCDETWRIVIMVLPLVVFILIVLVIIDIFCRCRSIKALQKGTSGSSVDDGMVVNPTYEQGNIIIDQSTGATTDVSTVNTVDEQPQSRDEPPDYEDVDYTQLNEVPHPRRSTKRQECHALEPIGYDTPDVFYHVLEPPNIESSDGPQCYATNHSGKEASSVFYHVLEPPEIESDGPQFHAPEPVGNGAPEVSYHTLESPTALNRPTYQNLSEVNHYTLNPLYESAENSAPLVEANKLYDNSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6S3</accession>
    <name>A0A6P8H6S3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116288406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551053.1">
        <property type="nucleotide sequence ID" value="XM_031695193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6S3"/>
    <dbReference type="FunCoup" id="A0A6P8H6S3">
        <property type="interactions" value="2411"/>
    </dbReference>
    <dbReference type="GeneID" id="116288406"/>
    <dbReference type="KEGG" id="aten:116288406"/>
    <dbReference type="InParanoid" id="A0A6P8H6S3"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551053.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13646" checksum="A8921A7B98C3D803" modified="2020-12-02" version="1">MTSLLNKPKSEMTPEELAQREQEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLARVKAFDRHCNMVLENVREMWTETPKSGKGKKKAKPVNKDRYIAKMFLRGDSVILVLRNPMATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H887</accession>
    <name>A0A6P8H887_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031551716.1">
        <property type="nucleotide sequence ID" value="XM_031695856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H887"/>
    <dbReference type="GeneID" id="116288981"/>
    <dbReference type="KEGG" id="aten:116288981"/>
    <dbReference type="InParanoid" id="A0A6P8H887"/>
    <dbReference type="OrthoDB" id="5985770at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049100">
        <property type="entry name" value="TAGT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20691">
        <property type="entry name" value="TAGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TET-Associated Glycosyltransferase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551716.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46993" checksum="C05EFBBD7EB57DD6" modified="2020-12-02" version="1">MTTSSNAEDELVEGISNLELETNETPTETLQETPHEWLKDHPWQDHQANDYLNEDFDNLISYSNRYPVSKKWKQGEKIDLRRVYRDLPTFIQEIKPKETQSDDGQRQNKSLEEGHYTAKSLPDPSTGTTNKDFEEQNLDVNGDMLKVSVPKHKKTFLEKSGFTSAERPNLTRRWIFIPSYMRANCGLFDWSEAGIDEEITIRIIVVRPSQFEEYQKHCGNYLPIISLPDNKIGVGYARYWIQKIATSLGLKYIWMIDDDVKQFYEVHPKRRRKLKKRYYLRRRRFNEVFTKFESIVKANEGNNLVAISPLGFPNLKFKEEEAFVRKPPRAAVFLNLKLINEKGVSYRPQLVRFEDMLFGKECEEKGLKVIMWRRIQVYSIKNWIKTGCSSPGGGGGGDGGEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAL0</accession>
    <name>A0A6P8HAL0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coactosin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116289850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552641.1">
        <property type="nucleotide sequence ID" value="XM_031696781.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HAL0">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="GeneID" id="116289850"/>
    <dbReference type="KEGG" id="aten:116289850"/>
    <dbReference type="InParanoid" id="A0A6P8HAL0"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF29">
        <property type="entry name" value="COACTOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031552641.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16249" checksum="ABE21E6DEC03090E" modified="2020-12-02" version="1">MPHNVDKHGVEEAYENIRNDHTDEIWASFGYDDNEKIVHLKSGXNYDHFLEELDDDRRLYAFVRVETGDELSKRAKFVFITWIGENVSPLKKAKVSTDKGNVKMVITNFAVEILCSDKNELLYDKVKCQVQKAGGAHYGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB83</accession>
    <name>A0A6P8HB83_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553719.1">
        <property type="nucleotide sequence ID" value="XM_031697859.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HB83">
        <property type="interactions" value="2107"/>
    </dbReference>
    <dbReference type="GeneID" id="116290755"/>
    <dbReference type="KEGG" id="aten:116290755"/>
    <dbReference type="InParanoid" id="A0A6P8HB83"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12413">
        <property type="entry name" value="RRM1_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12414">
        <property type="entry name" value="RRM2_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12415">
        <property type="entry name" value="RRM3_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12416">
        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000182">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="283"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="450"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="606"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553719.1"/>
        </source>
    </evidence>
    <sequence length="879" mass="100250" checksum="61F270A3D0DC5286" modified="2020-12-02" version="1">MATKEGXEVEKEEEKSNRISKKVLFVRNLPYDIKDEDFEKAFSDIGPIRRSYLIKEKGSNNCRGFGYVTFAIEEDTQRAMETVKMLGGRKLKFAFSDKKPRQNRREKHPNKEKKLQGSDHEDNHDDDDDDDENTNTDSSETKKDRKNFKKTEEEKEEENEAKHKSTTKPDGHPSSDSKTRKPKSQRAQPQSDVGRTVHVLGLPSTISAKEIYKRCRKVGEIENTVFPLEDRDEPVAALTFKTPKDARIAVAKLNKKVIKGKEVTVVLKSKEHQQLSQKSLKKSRLIVRNLSFKCTDAILKEFFSQYGEINEVNMPVTMKGRRKKKQGFAFVQFSDVFSAAKAREAMNLKEILGRPIAVDWAIPKDQYEKVGKSLQGNKDEKVEGAANQHDDDDDDENNDDNESHEEDERLEESGQESDDADDDKNDEEEDDDDEDSQESKKKPSDVKEGLTVFISNLNYDTTQKSLFQLFKKYGDIEYCKIVTDPLTDHSKGTAFVKFKALESVENCLEEANVEGVENEGLHLDGFKLRVHLAVTRGKAQQLRMENKESKKEPRDKRNLYLAREGVITAGSEAAKDLSKADLQKREKAETEKKAKLRNPNYFVSTTRLCVRNLPLSATEKELEKIFSTSGAVNGGKPALVKKVLIMRSKDRMDGSGKGRSLGFGFIELASHKEALTALRQTNNNPEIFGSNRRPIVEFSIENSLALKAKQQRMARSKNKEKPRVEKEEEIKTNKQRRIEKGVRRREKRKLKRLNKKNAGGKDASSVAEGSTNSRANKPNSGENFKKKKKQFPSKKQQKSLKKEPENLPTKETKSVKLFQRATKSAQKEPANQSFTGRKNSKRKAIDMKEEVEFNTIVQKYKSKLFGDSNSAAKRSRWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE41</accession>
    <name>A0A6P8HE41_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 436-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116290991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553971.1">
        <property type="nucleotide sequence ID" value="XM_031698111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290991"/>
    <dbReference type="KEGG" id="aten:116290991"/>
    <dbReference type="InParanoid" id="A0A6P8HE41"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
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    <sequence length="551" mass="63717" checksum="A2D587C640AA453D" modified="2020-12-02" version="1">MFVKRKTKEIIPFKVGWKKFSLSSLCIINVLFKTMEVNLCPAINFGQASCSVKYNNEASSDATLENEAVVELDQSVTVVYQNXGEVSMEVIYPENTERNAENRIYPVKNTSLGGPSELQTFLGQTEPLPTSXSNHPHEYDYADDKEEFPSTCSLCSIRCQSSKDLDDHLKTHCTKDTNECPVCNKKLSLRGSLFGHLRIHSKYKAYVCDKCNKAFNAQYQLAYHHCGDEKLKPYKCGYCENRFAVLISRIIHERVHVNKDSKLCIHCHKTFTNEREFQTHKCVALRVLKCASCNEEYPNEEQLLRHQRSHENFKPFKCSHCSKSFRRQSNLDTHVRIHTGIKPYKCDHCSKAFSRNDHLKNHVRIHTSTKPFQCKQCNKTFSNGTRLSLHERTHTAAREYNCNICDVVFQSYNEFKSHKLTHVTSKPYNCTYCGKRFARADHLRNHERIHTGVKPFGCSFCDKAFARQDHLKNHERIHTGVKPYTCEHCGKAFTRVSNLQTHLRIHTGIKPYKCEFCKKDFSRLDYLKSHERAAHMDNTALHSDILNNDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF43</accession>
    <name>A0A6P8HF43_ACTTE</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116291935</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC116291935</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        </source>
    </reference>
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            <begin position="158"/>
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    <sequence length="180" mass="20310" checksum="9BD822E3CE329408" modified="2020-12-02" version="1">MEASLVLWISLIIKVLLVSRTQGAARFTINPPSVSYVSVGKTIKLVWDYSVDSKREEFGVYSPKWIFYADNGSEFIIAQENVFNQGQWNIQKATCPARLLNPVRVSKESTATLVIHNVTLADSGTYGCVLMLAARSPITNKVKLVVTCGYDCFNLLKLLFLFRLDSFLVCLSFLFLFFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
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        <location>
            <begin position="1597"/>
            <end position="1790"/>
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            <begin position="15"/>
            <end position="39"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="47"/>
            <end position="85"/>
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        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031554426.1"/>
        </source>
    </evidence>
    <sequence length="1918" mass="217931" checksum="8AD6EF4ADD550494" modified="2020-12-02" version="1">MKLCERIQMYERKSMYSKSNPPSIKSVKSRASKGSLSSSMHSVSQARADVAAEAAQFQVEIEYLEREKELKRLELEKRLALAKAKENAYKNILDEDNRDEIDKINKDSTQNVKREMNPNIPPFVLKLKQEIKTEKEHNAEIIPPIPAANVTKQKLDPNSDHHTYQPQTLDHALGQLINLQAQQAHLSSLLIDQQRTSQLPVKEPPTFAGNSFEYPAFVTAFDNIISANVSDDKDRLFFLEKYTTGKANEAISGFLATNSDTAYREARKLLKQRFGNPVVVAEDYKRKLLEWKQVNDGDSQGLQDFSDFLVRCLEAMKTMKSMSELNSAKTLQSIVAKLPSYLGVKWCRSAHDKLSKEDRIVEFEDLAKFVKQEAELANDPIFSPEMLKRERRKNIPLTKDNRGARSRPQSGARPSQSLATSTTKAKQNEQRSPLPATATYGPTCLICDGKHAIAKCDTLNQTNADARFELVREKRLCFRCFKSGHVSADCPSKSTCGECGKRHHTLLHGSTPRTKSRDEQRTSATGPPRSQSKPSQSSPDAESAHSNATSVTHNSVGTYTTTLCRIVPVVLYHKDDPNTELKTYALLDDASDTTFVTNQMKNKLGLKGVGTNLNLSTMHGNEVIQVTRLDGLIVERPDRRATVELPKAYARDAIPSRRDQIPTPDVADKWQHLRRIKDKIPPIDDSLEVGILIGSNCPKAIKPKEIITGKSNDPYAVRTILGWCIVGPSNPSEATTDEEVLANCNRIIAREACNSDERVVQFVISKPTKELVNPIAVAKMFELDFVEHMASPTKGLSKEDRRFLQIASEGIHRTEDGHYELPLPLRDENVTLPDNRAAAARRLDQLKRRFESPNGKQYREDYIKSMNSMIDNGYAEMVPPDETTNGSDKNSLTKPKRWLIPHHGLYHPKKRKFRCVFDCAAVYQGQSLNKNLLQGPDLTNNLVGVLSRFRQEPVAFSCDIEGMFHQVRVNEEHRDLLRFLWWPNGDIKREPKEYRMTVHLFGATSSPGCANFALKATADDHETEFGAAAASFLRNDFYVDDGLKSVPTVDEAVKLVENVKEICRKGGFNLHKFLSNSKEVIRSIPEADRADGIKEMDLDLDSLPLERTLGVHWCIESDCFEFRIILQDKPCTRRGILSTISSIFDPLGFVAPLLLEGKSILQDLCREDLGWDDTIPDETKVTWERWRTELMQLQRISIPRCYKPDGFGRVVKTELHHFSDASTRGYGQCSYVRMIDEHDRIHCAFVIGKSRVAPLKPVTIPRLELTAAVCSTRISQQIHRELDYRVNRDFYWTDSKVVLGYINNESRRFHVFVSNRVQEIQDSTNSNDWRYIESKENPADEASRGMKAQELKDSRWILGPTFLWKKETEWPNSDENDYSLSNPQEDPEVKKSVVMATATSDQRSYPAMDERVERFSSWYRAKRAVALCMKCISRLKARIKKEKVEEEVRVEDVERAGRLIIRAAQERAFKDELKNMTNGSEEKKFRGELSKLDALIDEDGIIRAGGRLKHATLSAYVKHPIILPKGAHISLLVIRHFHERVSHQGKGITLNEIRSNGFWVVGGTSAVRSAIGRCVKCRKLRGPVVEQKMCDLPKDRLECCPPFTYCAVDYFGPFAIKEGRKELKRYGVLFTCLSSRAIHLETATSLETDTFLNALRRFLSRRGPVRQIRSDQGTNFVGAQRELKEAFNEMNVDNIKAELQKIQCDWVTFKMNVPAASHMGGVWERQIRTVRSVLSSLLLDNGSQLDDDSLRTFMCEAESIVNSRPLTINQLTDHDSPEPLTPSHLLTMKSKVLLPPPGNFEAADIYARKRWRRVQYLANQFWTRWRKEFLLSLQGRNKWTRTRRNLTIEDIVLIKDENLPRSTWQLARVSDVYPSSDGKVRKVQVALADGCLDKQGKRSAAVRYLDRPVQKLVLLMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGY6</accession>
    <name>A0A6P8HGY6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551857.1">
        <property type="nucleotide sequence ID" value="XM_031695997.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289108"/>
    <dbReference type="InParanoid" id="A0A6P8HGY6"/>
    <dbReference type="OrthoDB" id="5989200at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057926">
        <property type="entry name" value="QRICH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25561">
        <property type="entry name" value="QRICH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="QRICH1-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551857.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="60112" checksum="E6F998963534702A" modified="2020-12-02" version="1">MTADSLNFWLTKFVQEICKEDGQRYPPRSLYSIICGLQRHLDEGNGAEAVRLLNIEDRSLRVTCATRLFQEAVDEKLIRERTGHRSSALFTYEKASXQQEVHVSKILGPPKDIQPVTDTTIEDLSLISDIVDLEISDAFLSNMTLPNXTITSSNQDKDESLSLMPDFDISDDLLSSXTLPNETVTSNVSSTITNXTHTIAVVNGSESRGTLENSFRDVFNEINLVKENGYIMVDGSKVEVDFFLGGDYKFLLLVMGLSAANSIYACIWCKVHKNERGDMTKPDDYYDSGTMQRTLDELKKMAETGDFCCTSKPLLSIALNKIIPDELHLMLRVSDILIGNLIEDALQWDEKDQFRNXGKNLGTHLKKLVETICSCGVSFSVWEKNNADGRGSGTMDWTSLMGDDRKKLLNELPQKLGEAIQPDTAQAVADLWKKFADMYFGFISSLKPYNIDQYRAQIKQWIDDFTSLGHKRVGYKTERVTCYMHMAAYHIPNMVKTHDNLKQFSGQGNLIIDIENTVSCQQEYPSXVEYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH58</accession>
    <name>A0A6P8HH58_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116289190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the Deltex family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031551927.1">
        <property type="nucleotide sequence ID" value="XM_031696067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289190"/>
    <dbReference type="KEGG" id="aten:116289190"/>
    <dbReference type="InParanoid" id="A0A6P8HH58"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Macro" evidence="12">
        <location>
            <begin position="406"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="640"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="599"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551927.1"/>
        </source>
    </evidence>
    <sequence length="820" mass="91491" checksum="050EFC83B653D9C1" modified="2020-12-02" version="1">MDDPSFFKVELDEEEAKRSILITDVPENVSPKDVVIHFQKKSNGGGEVVNIDDHGNEHRSPVVITFEDPSIVGRAIELQHIINGKEVTVQRYPAETRIPEIFSLVDVRINLKVFDGSIFXLXEVLXYLXSELGIEYCENRYGYSIRGSYKQIRSCRNYIQDNIRNGKISQQMPRGCAIYGEAEEAASPEERDATSRSTETNDYKKNDAMTFQSVPIILQFIFTVSKYARRIQDIESEFNVKIGAVDGGSKVXIXPLPGCTQTKHHDACEEYIELYKEVCDSPKMSKNLLLRPGIGSDFSVKEVVMKVLLMEPVAIQEMEEQDKWLFYGEETNVRSAINAVCNMLKIDNPLRKTRKARVRQVTENDAGTAHSLPKQSGNDKAEEHAVQKHPNNVRSHIHKDFPGDTEQPCVVQTKKGFRXTVYQGDIVEERVDVIVSTTDDSLGFFAGLSKAIVDKGGRTIEKEIVAESKRKKIKPGNIIVTGPGNLHCLKILHLITNRHKRTKEKCKAIANAGCLHCLKVAQKQKLTSIAFPALGTGLQGITLDTCAIAMLNAVEEYMKCNDPKVDAVADIRFVHLDARAAEVFKTEVTKRYGDSIVKPSGEKGYGRHTDYETLSPPSPDSKVVSSVDKKTGKKEDDDVCPICLDGFHDPTALPKCKHKFCKKCIDQAFQHRKACPTCGMAYGVHTGNMPPGTMNHYFDSYPHLPGYERCGTIRIDYNFPSGTQGPEHPNPGQWYGGTSRTAYLPDCQEGREVLDLLKKAFNARLTFTIGRSVTTGASNVVTWNDIHHKTNPYGGSTGFGYPDPTYLKRVKDELAAKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHG4</accession>
    <name>A0A6P8HHG4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031552015.1">
        <property type="nucleotide sequence ID" value="XM_031696155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHG4"/>
    <dbReference type="GeneID" id="116289259"/>
    <dbReference type="KEGG" id="aten:116289259"/>
    <dbReference type="InParanoid" id="A0A6P8HHG4"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552015.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48036" checksum="E36F87548B9159C8" modified="2020-12-02" version="1">MKASAWMRRIVDLLPIFYAVLTRVIFFIHGFLCVWVLAHCKQAMSYWWLMIGILCLLVEMCYTLVVRKGHEYKYFWPSCFFYMLTMVPIVWIIEIDLYHARETAVPQSDSTSTVPTTAASPEGCLSIGNTLNRQKKICELGLIIGIILGRWLLPRGDITRDQLSALLLGYVGTAADILELFEVFEEDKVVGRGDITFAVLGVYSWSLLQFTLVTTATTGKDNQIRITANKVDTEPSAEEVFNRKISSHNKYGNPTKYGNTVINASDDELKEKYIQRLRMKRRQTEKDLNNRGKGFKGVRERKVNPITTARGEVKEISRREMLLHGDIFGILAGILMQDGPFLVLRLVLIIKFSVISEMHIFFTCKNAIALSLLMYRLCILTCSGEDEVYDEHRENEWRLQNVQQAVYSDQFKASGAIQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHR8</accession>
    <name>A0A6P8HHR8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RUN and TBC1 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116291472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554503.1">
        <property type="nucleotide sequence ID" value="XM_031698643.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HHR8">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="GeneID" id="116291472"/>
    <dbReference type="KEGG" id="aten:116291472"/>
    <dbReference type="InParanoid" id="A0A6P8HHR8"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17688">
        <property type="entry name" value="RUN_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11813">
        <property type="entry name" value="SH3_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000012">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000013">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000115">
        <property type="entry name" value="Small G protein signaling modulator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035833">
        <property type="entry name" value="SGSM3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="191"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="558"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="633"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031554503.1"/>
        </source>
    </evidence>
    <sequence length="838" mass="95845" checksum="1D25A14297921B17" modified="2020-12-02" version="1">MAGQYMYRLCPSQLGEVLWRYSLKFHIYTQXCQAKCRRCISYVITPTLSEDEDDGNEDALAWDDSAIPVGGGSTPVTGSFVPAIGGPFSALTPSMWPQDILSRIQQTEDSGNRPEGQYDEFGFIMDGADLEHEYKDPDPGNFVTNEDEGLRLKWTAYLEFTQNQDVGDLTWDKVSPTFPRSEKLRELVFSGIPHSMRAPMWMRISGALQKKINAEFTYKQVARASSDENSLTAKQIEKDLQRTLPNNACFYKQTSIGLLRLRRILRGLAWLYPDIGYCQGMGMIVASLLLFVEEEDAFWLMCTVIEDLNPPSYFSSTLIGVQADQRVLRQLIVSYLPHTDEQLKEHDIELSLITLHWFLTAFASVVHMKILLRIWDVYFYEGSVTLFRITLGMLKLKEQVILTLDNSAQIFNALSDIPGDITDPELLIKASQKASASLTEVILDAHRKKHLAFLMADLGVLVDKDSGKHLTRHQVNRRQLSTHRSFFNLLFGKGQKSDGRSQGGNIQRPIEFVADLREAILHIAKHFDAIDPKKGLEVDYSMESHARDHERFVSVARNRRRRAKALLDFERHDDDELGFRKNDIITIISQKDEHCWVGELNGLRGWFPAKFVQILDERSKEYSSAGDDSVSETVTDLVRGGLCPSLKSIFEHGMRRPSILGGPCHPWLFIEEASQREVERDFQSVYSRLVLCKTFRLDEDGKVLSPEEILYRAVQSINMSHDASGSQMDVKFRSLMCYGLNEQCLHLWLESLCACEDTVAKWYHPWSFLRSPGWIQIKCELRMLSSFSFNLNVDWELTNEPKVVESVIGDEKHMQVTQPMKDGVRDMLVKHHLFSWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJL0</accession>
    <name>A0A6P8HJL0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Helicase with zinc finger domain 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116289966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552785.1">
        <property type="nucleotide sequence ID" value="XM_031696925.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HJL0">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="GeneID" id="116289966"/>
    <dbReference type="KEGG" id="aten:116289966"/>
    <dbReference type="InParanoid" id="A0A6P8HJL0"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000419">
        <property type="entry name" value="Probable helicase with zinc finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="655"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="8">
        <location>
            <begin position="1452"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="2331"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1103"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1993"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2000"/>
            <end position="2028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552785.1"/>
        </source>
    </evidence>
    <sequence length="2829" mass="322497" checksum="00A4F65C1735D3BB" modified="2020-12-02" version="1">MAQNPPNFQFGHGSSQTDSTSKASTEDSLETVNRQRIRKKKENTFKLPKGVNVICHHHETSRTPDVCQGCESECVYAYWSTVLKKWTKVRNIPPTIAKTTTINYCSGYRKGETCKRCTYAHGPELQMWNLQRQLEKNLPSPEKYLANQKLKSGNTNNPSCMVHTSQPSSSNNNSSSDSSSSNDNNSSSNNNSSNDNNSSSSNSNDNRSTQSANECFEDSENMIMQAIQNALGPTGPVKDIKHHELKLRESIPGVELFVNPENPHVQLAKENCDYNYTWEFRARLKVDQVHTIPGVYLQYHRHHFYISRIQVVAFGKSNDDVLLILDTPLKDDHYHRPSIQLDLNTKTVDFGVEVTFQASSSVTGSFIQRISFDFGTKGLLIKEFNIDFDSSKILQTLLEARQAIGLEIHPWDHRDAEIIRCKPHRAKKKLMSTYSLPEDTEKIVSVQMLDGTIRQDTYKQTMHQLLFAEEIYMRNLLSRLTPNKLKLQVTKCLDLGLGGMKCAEDGHFFGIIELDDGIEITPDDMAGRVCLRNVRSVLIMPNDHQKCLYEAAIESLQSKKVIIDLTPEICNELNIERHDSIVHDVCMRFNLNRVPHCVMHKAIDRLGPEHVFQLFPEKTSHAKKRKSKVKFQSLDPRLNECQKRVIRAIADVVPPSPPLVVFGPFGTGKTFTLNQAVIYLMKEKANRVLLCTHTNSAADIHLELLNKHLHGTNRELQCAEDILRIYSPETELNKTSDVVRNYALVKDGVFLMPTRKNVVDHRVVITTLTTAALLTDLDVSHGFFTHILIDEAAQAWETEALIPLALAGPNTKIVFTGDHMQMNPEVYSAFAREKGLQRSLPERLFSHYSEDTSSKDENVIFLLDNYRSNKDILDFPSKYFYNGNIKAKGHADNPSHPVMGSLSFHSTEGREARQHDNTYLNTAEVDKVVELVENLDRSWPECWGEKNLQDIAVVAAYSFQVRAIRERLRTKRLGSVTVETIHNVQGKEFRALVISTVRTRHSIEPSRLQDHHEDLSLQFLSDPKLLVTAVTRAKSLVAVVGDPVALCTIGSRECRSLWKNYISSCDNLKALYGTTWQDLVRKIGEIRAGDRVKNIFLNPEAASFVPGNSQSTDVDQETSDDDDDPNTEQLDEIIKAFIKKFKEREAFEKDFPYLSRNNEHSLPSGVDDAGARPPKRNHSRLLDLKSLRCKWLIRRKNGREEILLLDLGHDKRSDQPVVLNPEEEEPGIADPKELKQKLEGDPTRYLTARLHIGSDRFRTTYAVLQDKTKPDIQVKGSIRQAFNGDTVVIDLQRDNLAIKGNVGYFIGVLNQFADPRGRQYVCEVDHKNPSIMVPIDRSFTKIMNVSDKKCKDIPIYEKDERGRLEEIKMLSLQEAQSEKCLFLVEFLKWKKGFPLPLGCALKTIPRGDKLDTSKEILRTELGIPKNFSNDIQEVLQKSTPEVHQVQSELAKRTRVTNAFTIDPPQARDLDDAISLDVIGNEKFKVGIHIADVSFFVQSGTELDQKARQRGVSYYSGQSGEENIPMLPRELSENILSLLPNEDRLTVSVFVTLDSKGKVVGEEEILRTVTRSRCRLSYSQAQQILDMEKHDNVERVPAEVPPAIKRLHSLVVKRRWQRLKEASFDHSNNREHADAHELIEELMILANHTVGDKLLREVGKGTPFRTQDEPKVDNLNEWASSYGSFAKYSLALQPHLESKDIKPEVRETIMSKQNIFIKNEVWEEIRKAVASKDHRKVTRLICDPFCSLQIAIARQNLMKIQCRSQYQAGIEEPYHHSLKLRSYVHFTSPIRRYVDIEVHRLLLALIQGNGLNMEQQALSEDEMTTLCQRATLVKDNSGKFEKESERLYFASKLKQKSLTGMFVIDKIEEHAFTIHPVNPEQEQLLGNQKTISFDDLSPYSKSENTDGAPRTTLKWRFRMYIASSSRKSYRDFAGSKKDDPLFALSKDADDIKTFMEHKYRFEAHKIEGDTWMRIIDAIKTSSTPQLLRHLREADQMKQNVDDGDDDDDGDDDDDDDEDDDEDEDHDDEDDDHFFKINWKLKQYDMICLQLHSRLYRGMIQPDEQLLKVSPHFGICLEHHRDPRGCFACHATGQVNTMKVYQTIPSYIHRWKPLLEMESATGAVRQSDGYTLKDLEVTWSLKDDTIKGQYTLTSSYCEDRQIYFNRGDFTCVKISCGSVETSAETSSSLRYTKSPDNASTVIWIGHGIIKECLVKGEKTKEKDERKATVTLKILQMSSKFPHELQDEQRYRIMCDLDIIYQPLPLRRMNEALTVKLENGSDLVQKICLGKKTPKASFPLPHTKNELSLAVHFEKSGFHSLNEYQEKAVRQALKKNFSLIQGPPGTGKTVTGIHIAYWFAKVNSEMMPRNASEDEKPPAAPPQVLYCGPSNKSVDVVTEYLLRIPEMKDKILRVHGTLIQETEYPIPNKIGSCKPTTSKDELKIPEGEVKEVSLHHFIRSKASPYSEKLAEMEARFAELKNKKEEKKKKKKVPGAYVEEYCKLISEAERWAIQRTDKEIILCTCSRAGSRTITEFCDNIQQCIIDECGMCTEPESLVPMTSSNAKQFVLIGDHKQLQPIVIDRLAKSFGLQVSMFERLSNRAFMLEIQYRMHPSICEFPSKWFYGGKLETPDIVKSRTTANVQIWPAPVDKDLRCAFCHVEGEEKSTVISTAESGVDSKYNDEEAVKAVQVAEYLVDNHRQQIREKNIVILTPYRQQRKVIQDLLKDADKDILVTTIIKSQGSEWDYVILSLVRSVPEQELEPEPSSSWLGEHLGFITDDHQINVALTRAKHGLVIIGNKKLLSYSPTWAALIEQYEKNSCVVEGNQWPVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK64</accession>
    <name>A0A6P8HK64_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555283.1">
        <property type="nucleotide sequence ID" value="XM_031699423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK64"/>
    <dbReference type="GeneID" id="116292160"/>
    <dbReference type="KEGG" id="aten:116292160"/>
    <dbReference type="InParanoid" id="A0A6P8HK64"/>
    <dbReference type="OrthoDB" id="10405669at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555283.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27781" checksum="4D2C7A5BD2771C04" modified="2020-12-02" version="1">MISSLKTNCKIKTYIQRLNCVRIGQCLLLGQCCAACSSAKTNERSKESRKRKSDGEIHIFHNERYFSEDDWKKKSEIINKKLKASKTREARLAEKFQDQLIDLESDDHNDLAWIMDNENNNIPEDMKTLWHQQIEITQTASKNGYRWHPKIIKLCLELYCKNPHVLEPLRNVMHLPSNRSIRYYKNKCEQQSGWNKNIVEWCLKDARERNLRECDYWGGFVIDEMKIEVMIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKP7</accession>
    <name>A0A6P8HKP7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553267.1">
        <property type="nucleotide sequence ID" value="XM_031697407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKP7"/>
    <dbReference type="FunCoup" id="A0A6P8HKP7">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="GeneID" id="116290386"/>
    <dbReference type="KEGG" id="aten:116290386"/>
    <dbReference type="InParanoid" id="A0A6P8HKP7"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553267.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="32461" checksum="3DFE287AD895397C" modified="2020-12-02" version="1">MNIHLPIRAGFAFGSCSLIVRRALKTNSLDLSGAIAALLVGFVLTLTNLCFFSSLLIFFLSSSMLTKFRSEVKREIEDDFKEGGQRNWIQVFCNGGVACLLAAVYFLDNGCGERPIDYARDFDASLIAMAILGAIACSCGDTWSSEIGTAFPSNKPRLITTLRQVPTGTNGGVTFIGLLASITGGLLVGIAYYAVLVMSMFFRGKSNGYPQQWPIILIGCAGGFIGSIVDSILGATVQYSGYCSVRKKVVNKPAPNAKHISGCPLIHNHTVNLVSSAVTSVAMSIFGYYLWKFIDSQYRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL95</accession>
    <name>A0A6P8HL95_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurotrypsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555708.1">
        <property type="nucleotide sequence ID" value="XM_031699848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292508"/>
    <dbReference type="KEGG" id="aten:116292508"/>
    <dbReference type="InParanoid" id="A0A6P8HL95"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="72"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031555708.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25068" checksum="DEB3CE83D9DD0D54" modified="2020-12-02" version="1">MLGYEAAEHLIRYIEGEIPRRTLLKYMACRGREKSIAECAHLEWWNVYLFCSNKRLAGVICQTNEDPPPVHVRLAGGRSGNSGRLEVRYHGQWGTXCNXGXDMKDAEVVCRMLGYPGVQEYITTNFTPVKGIVWLMNVGCTGRETSXTDCSHNGWGNAACYHSNDVGRKPEIPQKNPHGKVENKTSNNLNSHVVKSEPQGSNPEPSGEKRAVNLYTTHATQYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMJ7</accession>
    <name>A0A6P8HMJ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Caltractin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116290883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553862.1">
        <property type="nucleotide sequence ID" value="XM_031698002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMJ7"/>
    <dbReference type="GeneID" id="116290883"/>
    <dbReference type="KEGG" id="aten:116290883"/>
    <dbReference type="InParanoid" id="A0A6P8HMJ7"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031553862.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26863" checksum="ABE500548DE92028" modified="2020-12-02" version="1">MPKKTGKGKKKVKKKKSTKSPETTTEIGKVSNKTMVQQMASVSLSPTPTRKSTARERLVEAVQQAEMEKERRFMKGKISSKAYEQLTPHEIRDLRIVFDTFDTDRSGSIDARELRKAMRTLGFKIPKASLEAMISNLDTDESGEIEFDEFLDFIVSRQADSRDVHDEILQGFKMFDTDKSGHISLDDLKKVSRLSGLKLNEKELKEMIYEADKDGDNQVDQEEFVNMMLKTNLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMY3</accession>
    <name>A0A6P8HMY3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein DDB_G0281931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557071.1">
        <property type="nucleotide sequence ID" value="XM_031701211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMY3"/>
    <dbReference type="GeneID" id="116293751"/>
    <dbReference type="KEGG" id="aten:116293751"/>
    <dbReference type="InParanoid" id="A0A6P8HMY3"/>
    <dbReference type="OrthoDB" id="5959161at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052941">
        <property type="entry name" value="StomDev_PlantInt_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48004:SF59">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48004">
        <property type="entry name" value="OS01G0149700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028411082" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="894"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557071.1"/>
        </source>
    </evidence>
    <sequence length="1101" mass="124690" checksum="061D5CB71ABE899C" modified="2020-12-02" version="1">MNIFGVNWLPIFALLLSLFSFCDRASSYRSSLHERRLKPAHLNFNKNEFCLDSLPVPDNLQPDTTFTTDEEAIVLQDIYRSTGGPYWTHQRGWNDPDHIHHCSWYGVKCDNRTHYVISLDFSENNLTNTLPSSLWKLRNLLALCAPSNTRLGGELRSFLFPNMSRLIRIDLAYCSLTGHIPQNIANLLSLVKIQLCCQQGLGLSGPIPYWIGNLTDLQVLSIGENDVSGDIPESIGKLYKLRFLDLEILSGLRGNIELFYNLSSMVFLHVSNCGIHGNISDDFGTFYPEMNQCLLPQNNLQGMIPSSIKAMKNLTQLVLSQNKLTGVIPRAIGDLPSLRIVDLSGNDLLGFQNGTMLHSSKIEVLILSNNRRFSSEFNNLIISLMPLNQSIRILNVSTCHLTGYIPVQLWSFPNLISIDIRDNEIRGAIPDVPFDLLFLLKIDFSINQLSGPVPASFSQLHVLQDLDISGNPSMSSPLDDKRMLQNFFEPDLNVLVKKDPSDKFSCPYVRFSFNNGLVILDPSYYAYSYCVCDIGYYGYGNICRECMEGGKCMDRQDGSTYPSVMTISTGYWPSPSPKNTSHLVSCDPKGLSITQLSSCNPNGSCTCNFVKNGNSYYTHCEPSGICSEGSYDRFCTRCMTSYYRSGNICSKCPDYSNSVNMITLFVVMLVLSLVVLWWAFIYVRKRTRYLALVVAIGQVLLLGILWCFQLIPGWLFEINVLFLLFYVAGSGKRTRGLVKISIFYIQIVDAMISAHSSTWPPEILQAHHYISSVVNFHFLGMACEFPSLFTPIGKITSVLLVPLVGLTLVWMYYVIVYLRYRKSSHETHRRRVQRRQWECRQASIVILNIIYFPVVKQTITMIAPCDHDGYVSYMHTAPWVECTSRNHTYVALRVIAWGAFVFYVLGIPLCVFLPLLRKYLTLRKAQENDEENLELKEKQAMMDLWLGSIYLPYKESVRAGFETVALLRKFLIAFVIAFLQSTSIYQTLFLLLILSISLIVQLSLTPYIDSFKTFPLENACETIVLLVLLHSFVAIQLAELTRDTVLLWVVIGTNMAVVVLLVASVIIVFLRNWLIKRIHPEMEGERISQTSQTTVTQQGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNI0</accession>
    <name>A0A6P8HNI0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysophospholipid acyltransferase 5</fullName>
            <ecNumber evidence="16">2.3.1.23</ecNumber>
            <ecNumber evidence="17">2.3.1.n6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116293879</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.23" evidence="16"/>
    <dbReference type="EC" id="2.3.1.n6" evidence="17"/>
    <dbReference type="RefSeq" id="XP_031557236.1">
        <property type="nucleotide sequence ID" value="XM_031701376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNI0"/>
    <dbReference type="GeneID" id="116293879"/>
    <dbReference type="KEGG" id="aten:116293879"/>
    <dbReference type="InParanoid" id="A0A6P8HNI0"/>
    <dbReference type="OrthoDB" id="5974730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071617">
        <property type="term" value="F:lysophospholipid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF14">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031557236.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16119" checksum="9D91AF2081E9FFCD" modified="2020-12-02" version="1">MLILNITKFKFKFLINKKYPLLSTGWNCLHSLANIILAYCLLHQGGPTLTTVVCSFILNLGYLHVAYYCRSLDEFMLDWSVPHCILCLRLIGIAWDYYDGNNFNNNKISEDMKATRISTPPTLFEMTGFCYFFGGVLVGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNJ5</accession>
    <name>A0A6P8HNJ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Forkhead box protein J3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557251.1">
        <property type="nucleotide sequence ID" value="XM_031701391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNJ5"/>
    <dbReference type="FunCoup" id="A0A6P8HNJ5">
        <property type="interactions" value="1410"/>
    </dbReference>
    <dbReference type="GeneID" id="116293894"/>
    <dbReference type="KEGG" id="aten:116293894"/>
    <dbReference type="InParanoid" id="A0A6P8HNJ5"/>
    <dbReference type="OrthoDB" id="10029558at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20052">
        <property type="entry name" value="FH_FOXJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000088">
        <property type="entry name" value="Forkhead box protein J3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="72"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="72"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557251.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="51553" checksum="B48FBF0B4E664DD9" modified="2020-12-02" version="1">MADLNSSLTAMDWLPKLSVGSALSGQQLKNNNNNNDACKDKQAVRKAPGSPLDPGAVLDETEARQHQTRESKPPYSYANLITFAINSSPKKKMTLSEIYQWICDHFPYYKDAGNGWKNSIRHNLSLNKCFMKVPRSKDDPGKGSYWAIDQNPQEESFPSRQNRKRKPSDSRLSPCGTEENQWSPNSSQGSNLSSSPVAHSPTLASLQGDHFYTSSPNSQSFLGVSPSSSSNVHSGNGMMGNGAQGGLNNSNNFGEPPHKIFPEIAFEDLSASFKNLYKSVFDASQNSSSFGTMRSSDPAATQHVATSLPQAKQQQQHLMQNMETLLESMNKGNIQNIDLGHWQNLMESMKDIDFTNIGLDASQWQELAYSFSQYLSQQNLLGSGEMQSSQGFGLMQSPNIPVQQSSSTYSSSTPQSSLHGSHTSYNSSAGFSAGSNHSIPGIKVTPVSQSVQGGTQLDDEEEEDFDWESIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRV1</accession>
    <name>A0A6P8HRV1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555370.1">
        <property type="nucleotide sequence ID" value="XM_031699510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRV1"/>
    <dbReference type="FunCoup" id="A0A6P8HRV1">
        <property type="interactions" value="1194"/>
    </dbReference>
    <dbReference type="GeneID" id="116292229"/>
    <dbReference type="KEGG" id="aten:116292229"/>
    <dbReference type="InParanoid" id="A0A6P8HRV1"/>
    <dbReference type="OrthoDB" id="5988811at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555370.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28723" checksum="6A75353B25DEFFCC" modified="2020-12-02" version="1">MTSYYSSPTRLLPLYQKIAVSSSKSKMASVARGRLGCSLSFSVRLFLQNYSRGLSTAAKHLEKDGMSKKELKRVNKEANMKVQVDYKEATRKVVSLFREERLENLRQREAAEGEQQKLLEREKVEEKRIIEGVKMENLKLADMRKERIEIEEWTRRFRDMRREARHIQHQERLREKRIAMVKQAIEESKDFITPENLEEKINYALDNETNYNFALKPNGERIYSTKPPGNVETDQPGPAAFGFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS81</accession>
    <name>A0A6P8HS81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Probable G-protein coupled receptor No9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116292356</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555515.1">
        <property type="nucleotide sequence ID" value="XM_031699655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HS81"/>
    <dbReference type="GeneID" id="116292356"/>
    <dbReference type="KEGG" id="aten:116292356"/>
    <dbReference type="InParanoid" id="A0A6P8HS81"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="52"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031555515.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39766" checksum="4FC7FD5212AFF417" modified="2020-12-02" version="1">MAQTFFQHLRSNQTTRQTNLTSGDSDSSLSTLAETVFFSCFYLVISLTAMFGNLLVMVAIFVQSNLQTTSNYLLANLALTDFLQGFVSVPLRVAETLTWKTDVKLLCQISIPLSILFGSTSNVNILFISVERFVAIFMPYFYYEAVTPNFIFAVIGTSWIMITVLALAPSVGLGGLNPSPPVTICRFTTLLSKEYITTLYIIVHFIPITTVILIYGFILRASVNHNRRIHAQERFVVQPRNNEEVSNTKSTETLENTPEDRRNSIKQMKAARIVSFVVGFFIVLVVPIIVIDVVEMFGGPKAPSVLVKIAVCMIYTNHCVNVFVYAGCNRDYRRAFGKIFRKIREFFSKCDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS88</accession>
    <name>A0A6P8HS88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Influenza virus NS1A-binding protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558033.1">
        <property type="nucleotide sequence ID" value="XM_031702173.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HS88">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="GeneID" id="116294549"/>
    <dbReference type="KEGG" id="aten:116294549"/>
    <dbReference type="InParanoid" id="A0A6P8HS88"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
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        <property type="entry name" value="Kelch_1"/>
    </dbReference>
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        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF26">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558033.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="70823" checksum="1CFAC43A85524E01" modified="2020-12-02" version="1">MEIAVVEKSWPKLSYFQHEHPSMVLRELNQQRRSGNFCDVLLKVEEVEIAVHRAVISSTFPKLKDSLQNHKDCSIFEIDGLKSEAVEALVDFSYTSQLDVPPDSIFSVMVAAHKFGMAELESVLEAFIIESILPQNWLCVWKFTDLFPQLRSAVEKFLAENTAALFHKQDFLRLPHLQIELTGRQGDTKNNMDPKDICEKAVLWIHSQLQEDINLSVMLEQTHIMYITPEGDLKECTAEDLGDMEKFVATDAQMEYIRQSSTEQLSKMDTHVSDDEGIIILDNNNVCKRKISPFSGEFKVLSAIHSSESDFFGFALVNGKVTALSIHQQLPISSHHSTSSESSGYEDWTLIASMSRGRCSVGAAELSGKLFAVGGYDRGDCLHTVEVYDPLTNEWMPAAHLHSNRGRFKLCALSDIIYAIGGSDGHNELNTVECYDITSDTWSIKAPMGYCRSSLGTAILDDKLYAIGGYSGSHNLKTAERYDPSTDKWQQIASLSCGRENLCAASLDGKVYAIGGYNGWSYFNTVECYDPVKDTWTFTXPMKVARRGAAAAAMDGCLYVVGGYDGTTFLNSVECYNPQTNTWTTVASMNTARHNVGVAVVGGQIYAVGGFNGSAFLKTMETYDPKSNKWKSFVLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSS4</accession>
    <name>A0A6P8HSS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116294750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558268.1">
        <property type="nucleotide sequence ID" value="XM_031702408.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294750"/>
    <dbReference type="KEGG" id="aten:116294750"/>
    <dbReference type="InParanoid" id="A0A6P8HSS4"/>
    <dbReference type="OrthoDB" id="5945231at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF42">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028370269" evidence="2">
        <location>
            <begin position="23"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558268.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45165" checksum="87D23EFFBF1676CC" modified="2020-12-02" version="1">MDLTVFFTQILLIGYILTANLARCCTNQTRFCERINFDLFKDTLKNRALKGHSFLAVAVQDASECQMKCISDCRCLSTNYIESSKGEYGRCELNSADHVLNPLQLVETPASYYYKLERKFICEKDEAVFDPIRHTCPKSCCLPSTCPPHTTCRDMCLPKFKRFMCVCPPGNTNGCKELPRSCSDIARIFGFSPADGLYLVYDSQENLYQVYCDFSSEPRFAFTLIESFSFVNRDIFKRLGFYTDAPMGQESFKWEKHRLSKTRMQVIANHSTHLRSTCNRPTAFRYTDYFRVKLQELDLFKVFEAKCPRYERINFSGHECFNCTVGTWHVANEHFHVNGYYSVSLAGCEYXYTGFNQVLFGFYPVSAVNPGSFSCCNADESTTQYWIGSSVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTA6</accession>
    <name>A0A6P8HTA6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Baculoviral IAP repeat-containing protein 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558463.1">
        <property type="nucleotide sequence ID" value="XM_031702603.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HTA6">
        <property type="interactions" value="3502"/>
    </dbReference>
    <dbReference type="GeneID" id="116294914"/>
    <dbReference type="KEGG" id="aten:116294914"/>
    <dbReference type="InParanoid" id="A0A6P8HTA6"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000014">
        <property type="entry name" value="Baculoviral IAP repeat-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022103">
        <property type="entry name" value="BIRC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
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            <dbReference type="PROSITE" id="PS50127"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <name evidence="14" type="primary">LOC116295450</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
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    <sequence length="95" mass="9943" checksum="F93F2AF8AC4A29E4" modified="2020-12-02" version="1">MVEKSPSSTNVGAGRAPSKAVASRGSGSQVRQRKGGASSSGRSIRAASXGSSGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRG</sequence>
</entry>
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        <name type="scientific">Actinia tenebrosa</name>
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                <consortium name="RefSeq"/>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="PX_dom_sf"/>
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        <property type="entry name" value="SNX10/11"/>
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        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46209:SF3">
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="15"/>
            <end position="133"/>
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            <begin position="161"/>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50195"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559171.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38260" checksum="FBFF06A0D232BA5B" modified="2020-12-02" version="1">MIRDHVSSPGFGSSCLDVDVKNPRTHIDRGKALYTDYEIEVKTNHPSFPLLYSKTRRRYSEFVWLRNQLGLNDVLMHAAPRLPGKQLIGRFKESFLQERSEGLKIFLKRLAAEHSYLQEPSLQLFLQTNLSTSQMDHYMKTRTTGAIRSLIMMLHTKGLKKRERKISTKQQSNEYPPTKKNLRQHAGGRGWSSRYGDGYYNLPFGYRDETDFDEKDVRQRSSTLNAGALPGGRLTLPTIPGSMDESFPCSGSELTTTTDEEEDIDFRPLSASWHGSQHDQVDFILDDYEVIPIDIISKIEDEHKAEISDLGYLDLTTTTDQLNSYSNEQACFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWW3</accession>
    <name>A0A6P8HWW3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">WD repeat-containing protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterodimer with the catalytic subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557155.1">
        <property type="nucleotide sequence ID" value="XM_031701295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWW3"/>
    <dbReference type="FunCoup" id="A0A6P8HWW3">
        <property type="interactions" value="1059"/>
    </dbReference>
    <dbReference type="GeneID" id="116293814"/>
    <dbReference type="KEGG" id="aten:116293814"/>
    <dbReference type="InParanoid" id="A0A6P8HWW3"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557155.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45706" checksum="40D3E0CA5BC200CD" modified="2020-12-02" version="1">MASLVFSNNSLLALISCSKFRILDCNDGSCKFSCELSSIKPNTDSKTTKPDTSDAKQDPALGHGNIGCFSSSGRYFSLCMTNKTVTLWETDTWKCLSTRSLEKKATAILFTKDENYIVVADKTGDVYKFSTNDVHSEGILLLGHISMIMDMAFSNADKFIITAERDEKIKVTHFPNCHNIEAYCLGHTDFVSSIGVIKSEDDEILVSGSGDGCVMFWDFKSGKRLHTECLNEQKEEEGKEIQDDKVIVSVSCCPKNNVVCVMTESSCLLHLYHVSNDNNLKVTKLPTVTTSVPPWNITFDSNGLLWCLQPMKSEPLMVFHPEGAVQHIKYVKLEQFEDLPVYSTASDWTYLEECVGKEKQLSALRRKKDMDNLKEYLTKKEERIRQKKARLGGLDVEECDAKRIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXA0</accession>
    <name>A0A6P8HXA0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293928</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031557290.1">
        <property type="nucleotide sequence ID" value="XM_031701430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293928"/>
    <dbReference type="KEGG" id="aten:116293928"/>
    <dbReference type="InParanoid" id="A0A6P8HXA0"/>
    <dbReference type="OrthoDB" id="6086616at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557290.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41766" checksum="074FC2BDC23E55D0" modified="2020-12-02" version="1">MKTSPRIKMKAFGFGIIAIILILTFVYAVSPPLLENNRTRIAQFLEKSDMTEMGLQQYVHPHNISVKGIKFKLTFHTYNLAMQLMAQLESGKKVDETLTMDSLIEAMAPVTAVSSNHLHELLKHLDNFHRFXPNKKLIVYDLGLTXXDVXTLXXIDYVEYRNFDFSVYPKHVRNLNSYAWKPLIIQQILAEQGGALWMDSSVKIKKPYNKVLERMVNSSSGFLFYLHPVGHSILSATHSKMFEYLPMNNLNDMKLNQFQATGFIVFNTPQIRKLIFKWAILCSLVEDCIIPKGSTKSCGPKFPKEPASGCHRYDQSMFSILTRNEFGPETKRYVIPEKLEYADVNRLGLTFYRKVAIFFQSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY23</accession>
    <name>A0A6P8HY23_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermatogenesis-associated protein 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561269.1">
        <property type="nucleotide sequence ID" value="XM_031705409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HY23"/>
    <dbReference type="FunCoup" id="A0A6P8HY23">
        <property type="interactions" value="954"/>
    </dbReference>
    <dbReference type="GeneID" id="116297224"/>
    <dbReference type="KEGG" id="aten:116297224"/>
    <dbReference type="InParanoid" id="A0A6P8HY23"/>
    <dbReference type="OrthoDB" id="10047985at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029176">
        <property type="entry name" value="SPATA24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35155">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35155:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15175">
        <property type="entry name" value="SPATA24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561269.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22811" checksum="16235FE598B3BC3B" modified="2020-12-02" version="1">MAAEKVPSYMIVNKQLQDLVRIQDNILAKSIAMNDSRKENVVPLEEYEKVVRQFENEQLEHIKTKAKLASVSEKLEFALGEIDILTKQLNREKMAFEKSFGNLKHIANEESQAKNELLNKCGEMEMICSKQDDVLSSKDAQIKDLKQRLAKQKQNHKQCLSEMEIQRQQERYIIMNTHKTKDSSNNTRQRRVTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0C7</accession>
    <name>A0A6P8I0C7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC116297149</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116297149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561173.1">
        <property type="nucleotide sequence ID" value="XM_031705313.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561174.1">
        <property type="nucleotide sequence ID" value="XM_031705314.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116297149"/>
    <dbReference type="OrthoDB" id="567787at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF36">
        <property type="entry name" value="PROTEIN FAM234A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="6">
        <location>
            <begin position="146"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="8">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031561173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561174.1"/>
        </source>
    </evidence>
    <sequence length="776" mass="87276" checksum="938A4B6076E5A92A" modified="2020-12-02" version="1">MALSNMYKPQTNNILDLESDEDDFTEDELDNELDDYSKSFSVRHVSSKSEVQKPLMAPHTKTKIRHKHTKPWCTTKSCLSCFMWLAFFSICVVGLVLLILRAIDSADLNANSESNHVKKGIQGEHVFYGNDKNIEACDVLKTKNIWHSNLPKLMTETAVRLNDVNGDGVKDIIISFSTGVDAHKPPRLSCDLYFNGSYPCFGGALALDGNTGKELWRHYSMHEIYALNCNGDLDHDGTWDCLLGGRGGAFQAISGKTGKLLWNMDEQPARDENMNFYTAQFIRDLDGDGVMEVLAAHGGDPLAEANSPKRLKGRLIIFSGKTGKVLRWTIVPDEREIYFSPVLYHKKDGRQMVIFGTGGETHPGGLWVIPLMNLYLGMVETAQQIYEDKYKGVMTPPLLVDLNKDGTVDIVISMFNTTVAAFDGETYKMIWNYSFPNSESYATPGAGLYNDDDIPDIMVRYNYGPGFPIYYYSQVTILDGXTGQPLVTPFKKSSVXVNSSPLSVSMEGLGNDLFIYWMADCKGFEGDGKEFSFVEGTNVHEQSRADTCQLRYNTKSFSKLNIMNRRTGFPGKTIYNSDEYWELEHSENDTIPSKKEGRRKRHIGVPDHGGFQRIIATGGLAPSLQVGNDGPANSIDVVFTTYWQYPAKVRIILPEDKACXEHYRKLAKQGKFKNKVNTEENEKLGIYDAGDAAVNICLKKKEKASSTNTDKIYVSQEDFDWYKIHFGSLTVYRFQISCECKSLVTENKCSRFLPMNQQGWGGYMGTLGNSYYLPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0Q2</accession>
    <name>A0A6P8I0Q2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116294908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116294908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558457.1">
        <property type="nucleotide sequence ID" value="XM_031702597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0Q2"/>
    <dbReference type="GeneID" id="116294908"/>
    <dbReference type="KEGG" id="aten:116294908"/>
    <dbReference type="InParanoid" id="A0A6P8I0Q2"/>
    <dbReference type="OrthoDB" id="5958350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028095775" evidence="5">
        <location>
            <begin position="25"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="6">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="6">
        <location>
            <begin position="166"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558457.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41270" checksum="579A2154FFA56740" modified="2020-12-02" version="1">MGFLRVVSLGVMLSLLFLQLHVEGKQCVRFEDSPLRRCAAAGYNYTYALPDDLSDSTTRYIVRLVDYLSNATVNCSVAQIAEAITCMSFAPKCVDAEKEPVLPCRRVCSELLKRCSESIREYIVDWMIQICLVLPNATAESGKCFEPKQFDKHYNATSKGPLERGCQKLVNFPFCEGMGYTYTIPTPEAQLKTYRFFYDKNMTDGDKTKPANNSILQRVIWRINNTPKCGKNIKKLFCADVVPPCFPPEEKSYYTVCQPVCKAIGEQCPEVLEGRGSIYYKTCERMAPGNSSHGYCRHTKLPPIIDWADYFKDPPTPTTPKGLSTTTIVIIAVVVPVIVIAVITTVVIMYMKRKKSDLFNYQRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1F0</accession>
    <name>A0A6P8I1F0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295117 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558717.1">
        <property type="nucleotide sequence ID" value="XM_031702857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1F0"/>
    <dbReference type="GeneID" id="116295117"/>
    <dbReference type="KEGG" id="aten:116295117"/>
    <dbReference type="InParanoid" id="A0A6P8I1F0"/>
    <dbReference type="OrthoDB" id="5959702at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558717.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="83023" checksum="B1F3A35B8044F18A" modified="2020-12-02" version="1">MTRYSLRLKMSYYLGRSDYSSYRSSYEPRKYSSLSKSSYGSGSYGSSYSRPSYADSYSWRNSSSLSSSYKPKTYDIGSSSFSSSYGSRYGDSSWRTRDLTNRDSSSKDYSSTTEDSKDYLSNDGNSTEESSSKDDTATEEYSAKTGKDALAKDFSEQNHSSNGSDMAKEEARESFVKEFFDKDNSDQESPSKTKGPLFKDFSSTGSSGRNLSSRRSENTSPKETKDFLGKYGSDSKQKNYLNKYLKEDDKGKITNGEVKDFSQTNDASSYEKDKYGRYGFLNSTKNSGHRDRNDYTLDDKTAKEERKFTPNKKVYSFEDVIKEDTKDNALFASRGSDFDDVDSYKPKQSGRINGDSHGSLYKPKKSYFNQKNKNSRDSSQENRYSAPQKSNEDVSYSHPKMRGRASSDSGPRPVSLHRPEIQKFISVVPEENRYITSVNYLPDRIELRLCGTTPKEKKIKKWRSIPDLYNITLKPQQSGEEQISCEEEAVAYAYDSSNELLNYSMPKHEHMKEMYVTQYTHHFDPEEPRSHIAGWKVDVEPNGIPHERSRMCVLKHPVVSGPNKHRRTRPKSAPPMIPLRSKSPEEPIRLQQVDVVDRGYYTSPRSSRASESGFYNGIEDSTDVSSLGYAPSDDTSDSSAFLDPRSPNNKDSNFSFSKPKLIRLSAEFPGIRNLEKMRRKRQSMGSATSPRPRSSLGHSPSSRDGEYGFFVALTSGDSPKFQSKSGRSYSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1Y0</accession>
    <name>A0A6P8I1Y0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116298294</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562549.1">
        <property type="nucleotide sequence ID" value="XM_031706689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298294"/>
    <dbReference type="KEGG" id="aten:116298294"/>
    <dbReference type="InParanoid" id="A0A6P8I1Y0"/>
    <dbReference type="OrthoDB" id="5986399at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031562549.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18260" checksum="E40CA7A3A9A93006" modified="2020-12-02" version="1">MVDFSQDQVNTDQAPPVVTTKDVNAIKVFETVCATGLXXFGDNKPQPIPNKKNLTKLEGCLIDETGSIPITIWNEHIQLVQDGEFYKIQNMVVKQYFGXKFLSSTTSSNFQKVTENLPKLSPDVVQEAGDQLRNTEVRCSNFRSVDIITYYNCLNCAKRLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2E1</accession>
    <name>A0A6P8I2E1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116295406</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116295406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559062.1">
        <property type="nucleotide sequence ID" value="XM_031703202.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116295406"/>
    <dbReference type="InParanoid" id="A0A6P8I2E1"/>
    <dbReference type="OrthoDB" id="10360046at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011106">
        <property type="entry name" value="MANSC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF2">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23597">
        <property type="entry name" value="KIAA0319_N"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00765">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50986">
        <property type="entry name" value="MANSC"/>
        <property type="match status" value="1"/>
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<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Actinia tenebrosa</name>
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            <taxon>Cnidaria</taxon>
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            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <text evidence="14">Binds 1 zinc ion per subunit.</text>
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        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="530"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031559185.1"/>
        </source>
    </evidence>
    <sequence length="1080" mass="117873" checksum="B34ACAFEDD5B8FA9" modified="2020-12-02" version="1">MIVKALLLVGAICALQSMGSQAHPKDIPLHHRMTKQEIQQHFGVDSRSEVPEYXVVHPFLADHTGEFLSNDLSQKTRQRRSLGKDSELFYKMDALGKNIHVRVSKSDDILTPEAKVKIIEADGKIKVREPLRINYYQGHVVSDPNSVVAISNDDSGLTGMIQSKDDSLFIKPLSSHLAKHYNKKDGAISHIVYRRSTIDNSNCLQLQGQREKRSASIRSSDEPDARDADSTTKYLETHTIADQYYSQAHGDNTERDMLIVAHVTRLFLTHPSIGNIKLHLVVIGITIKQTFAYTKSATRIQRMDGLGKYLDTGVFPKEDSDPAHPDLALLMTSGLSGGVADSNSICTATYGRVITGDSGLASAIIIAHEISHALGAGHDGNRDDCPGGTFIMASSVPAGKKAFLFSPCTREFLQKVFSGSTCPSLNDVPERFLGFKAKWISKFPGVSFNGDQQCVLQFGAGYKQCPINKSNCKSLFCASGNSLQCVSKAAPPMDGTRCGVRNWCIKGVCEDDGSPLVNGGWSKWGVWSACSYSCGGGVQYRARTCTNPAPKNGGANCHGNSKGLWRSCNPEPCPDGAKNFREAQCLAFSPRFTPYYIAAKPCQLYCLEGSMNHDKGQAKDGSRCSGDKFVKDVCIENKCRKVGCDDVLESGKYIDRCGVCNGDSSSCGLISGTYSTRCGWGVDKACLMLTIPVGSTQVYVNQTNKDWDVLGVKGENDQWLWNMPSWSTVVEAAGTKVHYKHEENVYKDSIFIPGPTNAVLRVYHVYISGNKPITYKYFSNSVKTVVTGSDFEWVVSPWSACSKTCAKGKQTRSVICQRKDDKSMGRESLCSQNGPKPAMAQACKTQPCPAQWYESPWGPCTSSCGKGVQHRQIACRNLVAEGQYEVVSDSSCTGSKPAGATSQICNKISCPPMWLPGVWSSCSVSCGGGIRTRSVSCRFKDEDSLIKPMLDMYCTGLPKPALQEACNEDPCNAGGSVPHTYKPIGCFKDNGKSGARPFPVLTNLRGQIDWYNLQKTVDACAKLANVNDQVFGIEYYGECWYGPGSISTYNRDGKADPSRCVAGVGMENALQVYKFNXRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2Z2</accession>
    <name>A0A6P8I2Z2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116297997</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116297997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562198.1">
        <property type="nucleotide sequence ID" value="XM_031706338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297997"/>
    <dbReference type="KEGG" id="aten:116297997"/>
    <dbReference type="InParanoid" id="A0A6P8I2Z2"/>
    <dbReference type="OrthoDB" id="5987925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="5">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="CRC" evidence="6">
        <location>
            <begin position="317"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562198.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61038" checksum="0306E2BEE87FE277" modified="2020-12-02" version="1">MTCALYAWNWKRKGKSLQNKRTTPVVPVEIFKSSFTKPSPQEPRMKETTERDTAHSTSSLHVPFSTSATSVKKIKTETTLNYIIQRVLHLQDFCCAITTRCKIKTLDVIALLWSNSVTMNDLIENESKLNEIGLDLTDQRCDNLERNLSGLNLGLDKVARDGNCFFTAVSRQLKKHLMLYREQLEARCTMLGMGMSEEADKEKLRKLFVKEVLENIDYYKNWMTSDNYSXEVNKFNQDGYFASEVGDLCAKATARLLRIPIVIVTALPTQPTVPFLPQEFIIAIPIYIAYDHSGPGHYDGTIESSASDEQSIANVVNEKGCTCGKNSQKENKVSCVSDNCPCKRKKKSCTRKCRCCRCKNTQTAGKDAVVKESLYEKSCRCGQGRKSKGEQPIQEACRDGSRKSKCPCVASGIGCTKMCRCLNCANIIQSRVAPSTPTKPRKRKRELASPYKRKRGKTFMESKNVSMKPGIWINLEIYCLXICREVLLSQDISVEPSNLKSLYNFVAGSNNIKAMSLTINLKSQAQITAKLAHIKNYHKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I334</accession>
    <name>A0A6P8I334_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial glutamate carrier 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glutamate/H(+) symporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Solute carrier family 25 member 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">LOC116298580</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21 22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamate(in) + H(+)(in) = L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562954.1">
        <property type="nucleotide sequence ID" value="XM_031707094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562955.1">
        <property type="nucleotide sequence ID" value="XM_031707095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298580"/>
    <dbReference type="KEGG" id="aten:116298580"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000026">
        <property type="entry name" value="Putative mitochondrial glutamate carrier 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="101"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="226"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031562954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031562955.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35005" checksum="58B98AB74AC58E54" modified="2020-12-02" version="1">MENRNGFLAKLLNGAIAGVVGVSCTFPLDLCKTRLQNQLNGGPKLYKNVHDVLFQVARSEGLRGLYKGMGVNVVLINPEKAIKLAVNDQLRQMFGGKLHILPLHLEMIAGGTAGLCQVIITTPMEMLKIQLQMAGKQVGSQTVSNTINSGASAAASVHVRSFGTASVTAPTSALRITKDLLQTKGISGIYRGLGATLARDIPFSCIYFPIFAYLNLKGIQAEGGRPPLFYSLGAGCLAGLTACLAVNPMDVIKTRLQLLNRPQGQPPYNGIIDCXRKIYKNEGVLAFYKGAVPRMIVIAPLFGIAQTVYFVGVAEWIMGWDKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3D8</accession>
    <name>A0A6P8I3D8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain collagen C4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562353.1">
        <property type="nucleotide sequence ID" value="XM_031706493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3D8"/>
    <dbReference type="GeneID" id="116298124"/>
    <dbReference type="KEGG" id="aten:116298124"/>
    <dbReference type="InParanoid" id="A0A6P8I3D8"/>
    <dbReference type="OrthoDB" id="6086925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562353.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23217" checksum="95A1D4785C8909D7" modified="2020-12-02" version="1">RDGRDGKDVLPGPKGPPGLKGEIGHQGVRGPPGPKSGGVQYVRWGRSACPSNATLVKIRVIACSHKGGASDYVCLPETPKYGRYKDGLQSLGGYMYGAEYEVSFELFTKSGLYDHEVPCAVCSVQTPSAKLMIPATYECPAGWKREYHGYLMTEHSKHIHQTEFICVDQDAEFVSGTKPDLDGAVLYPVEGRCGSLPCLPYVEGRELTCVVCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3E4</accession>
    <name>A0A6P8I3E4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Dual specificity protein phosphatase 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116297850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562021.1">
        <property type="nucleotide sequence ID" value="XM_031706161.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562022.1">
        <property type="nucleotide sequence ID" value="XM_031706162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297850"/>
    <dbReference type="KEGG" id="aten:116297850"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031562021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562022.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23257" checksum="0D9FF7EC4A743A7C" modified="2020-12-02" version="1">MNFQSQIEKFSKERLKNVETRITTVEGKKLVESTXDGERVTVDTGLSSLGFCEDTNPDTKIYKVLDKLYISSQDGARNKNALTALKITHILNVATGVANAFLDDFTYKNVEILDLPETRIQPYFKEMFDFIEKGFHHGSVLVHCNAGVSRSTTVIVAFLMHKLHMSLNDALQMVKDSKPSVKPNDGFIRQLKEYEQQLGLYKDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4J0</accession>
    <name>A0A6P8I4J0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296003</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559827.1">
        <property type="nucleotide sequence ID" value="XM_031703967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4J0"/>
    <dbReference type="GeneID" id="116296003"/>
    <dbReference type="KEGG" id="aten:116296003"/>
    <dbReference type="InParanoid" id="A0A6P8I4J0"/>
    <dbReference type="OrthoDB" id="5947013at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028012123" evidence="2">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559827.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19762" checksum="02844C71A1EC63B4" modified="2020-12-02" version="1">MHVLVGLFCLCGMLVAANASISRPVLGAAPANEEVPEGGRHPNDDKRYTIEQLNLAARHRNVYYDRAGSDPYGISSPMISHMGKRSVTYRYPAGSDFHSASNPMFARKQMNIEEKRAHIARQNYAARHRNVYLDNYGSDPYGGGSPIVSRQTIRVPHRHGRSAEEKPQTLMQRLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I533</accession>
    <name>A0A6P8I533_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 183-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560037.1">
        <property type="nucleotide sequence ID" value="XM_031704177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I533"/>
    <dbReference type="FunCoup" id="A0A6P8I533">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="GeneID" id="116296192"/>
    <dbReference type="KEGG" id="aten:116296192"/>
    <dbReference type="InParanoid" id="A0A6P8I533"/>
    <dbReference type="OrthoDB" id="5955317at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026509">
        <property type="entry name" value="TMEM183"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560037.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="38063" checksum="52286B7AE7A7073A" modified="2020-12-02" version="1">ISQFLFTQEYESLREKQDDLLWYERDDLELDPNSTSNEETNDSADEKLESINEDTKEQEYNDEKKKKVKRKKVMKSKSFSGEYVYPLDLWCLLSKFIRPEDVLRFSLVCKGAFQAVTFSAFWLRLYNIYVCEPEKLPEHLQPSRIDCGTGLRTRVVQALFHQYGELKSRLVTVTGDSSCMDALLFYWCSSVWFHQKIKKDTKIWMFYFKLSSEKTKSSHTNPRRFSKKWFNTVDFVRDNPNEGFTVLAVSCLNFISFQPVIGMVLTEALVGVSQGMKHCRVKLMFHSHRKDKRYRPESGYQVILDPVQDVRVLKWWHPLYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7U8</accession>
    <name>A0A6P8I7U8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 221-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564098.1">
        <property type="nucleotide sequence ID" value="XM_031708238.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I7U8">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="GeneID" id="116299565"/>
    <dbReference type="KEGG" id="aten:116299565"/>
    <dbReference type="InParanoid" id="A0A6P8I7U8"/>
    <dbReference type="OrthoDB" id="5538672at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029676">
        <property type="entry name" value="CFAP221"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058536">
        <property type="entry name" value="Ig_CFAP65_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46500">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46500:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24507">
        <property type="entry name" value="Ig_CFAP65_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24771">
        <property type="entry name" value="Ig_CFAP74_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP65 fourth Ig-like" evidence="2">
        <location>
            <begin position="151"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564098.1"/>
        </source>
    </evidence>
    <sequence length="906" mass="102839" checksum="FD40A9AB64CE34E4" modified="2020-12-02" version="1">MAVTSRRVASETFGGLVAPSKELPVPNHLLDTKIFSKVSQNDFLQTKPSVVHYAGFKVGGKHIQVLNIINASSETQRMHIIPPSTQYFYIKYTKNERLVPGLSIEVTIEFKPDEWRYYYDCIRIHSKAEENLVVPIHAYPVMSSFQFPKEVHFGSVPLGESKTKAIPLKCEVPIDFEFQFNCLQYNTAFTVTPMSGVVPGXGEVQVHVTYTPTDFSTSVLRLQLLISQFNSEPQVCTFTGTSQPGQVKKLKEKEWGGDIPTLPYSKILDPLLIDPLGRTRIKKLKTRPWIPEDRIAKEVTKDGYRIPANGINNTFAVAKILNQQQGKLKAKDIRQAVQLKKDVAGSSKQMKETMFEYQVHQNVQEERQNQLRWCVNLGEDPITNSTKTQIMENRNKMDKEYKLLRGDPVIINEFDRSSTGCQLRRIHRQTDDVPNHQPKFDVLVNDEWSKRHMVIKKFVQAGRKVIIRTRATKNIHSLTEFLSGWRKGKFCRDQTRRQMAESEEEKLFIELQNSICASRVHPFCFPAYKSPDTKDDLDVDALGTLTVQPTIVNIKTHIPYYNLKVPKYYRVWGYNAHSVAAASSGYVTSKLVRNLRTGAQDEVVSLSSNIAVSSTTSQSPGFGDEEEELQVDDVGRGVTSSSLKSRATYMIPDETAMTEPEVAPLVVPAALFQPLPYHPMHIFNPAPGLQVFKPQLPYSEVDEDYHLCPLPRHRQPTRGSSGKPGRRYLERQDVIPSVMTWKRFPCHPLVSVTNHPTLSTVWLPRWSDPFSEDLLPTEVPLLLNGLPDDDYSSEEEIDEEDDVLNEIAVPTPEMVSAQFPTAEKVLAELQVQHPPSQLSDVMISVNTKLQPQLNYSSSNVVSSSRDQREKELNDFIKQRQNRLGTRISQRVTSMHDLLSLSDLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9B6</accession>
    <name>A0A6P8I9B6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SH3 and PX domain-containing protein 2A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116297206</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SH3PXD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561245.1">
        <property type="nucleotide sequence ID" value="XM_031705385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9B6"/>
    <dbReference type="FunCoup" id="A0A6P8I9B6">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="GeneID" id="116297206"/>
    <dbReference type="KEGG" id="aten:116297206"/>
    <dbReference type="InParanoid" id="A0A6P8I9B6"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06888">
        <property type="entry name" value="PX_FISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd12015">
        <property type="entry name" value="SH3_Tks_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12016">
        <property type="entry name" value="SH3_Tks_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000082">
        <property type="entry name" value="SH3 and PX domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037961">
        <property type="entry name" value="SH3PXD2_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="482"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="780"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="871"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="746"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="831"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031561245.1"/>
        </source>
    </evidence>
    <sequence length="928" mass="102699" checksum="53460B8421388FBF" modified="2020-12-02" version="1">MVKRTLTSVKIVDIQKRKVPSKHYVYVISVTWSDGSVNVVYRRYSKFFDLQTKLLEEFPVEGGVQNPSTRVIPFLPGKIIFGRSHVRDVALKRKESIDEYCSKLIELDPKLSQSDLVLKFFEPSSDDIDIPAEKKKKKNETADNISDPISLDQYVAIADYQKQNRNEISMAAEDVVEVIDKNENGWWFVNLDEEQGWVPAAYLEPLDGPSDDMDFTDVSSVEENQFITTTSHIAELDDEISFEMGVIVTVVKKNFDGWWLIRYQNKEGWAPAMYLKKPDPMQLHAAEIGGAVPKRDSVPVITHAPIMQQPTSNLARKGKGVPPRKASVKRSIRKPFSIANQSYEKHFEPVKETAAIHSEAEYVTIGDFRAVDIQSGLSFDKGEAVEILDKSPNGWWLGKIGGHEGWIPSSYVEKRNRSQKGNVVTPKPDRPQLPSSRLSISEIKPETSQSPDLKSDLNIALSSMRLKSCAASEPAEPSGQSSTKEMYAAVSDFEDSSDGVVCLKEGDVVEVVDKSEGEWWLVRLNEKQGWVPSSYLTKQEIKNSPAPRRPKPPASKPSSSSQGASKPALPAIPSSKPVSSQKMNKKPLLPSVPSGKPGTLRKTDGKPLPSPVLSGKPATLQKTNGKPTPPPVPSAKPTLAQKPKAKPSPHPVPKGKPAFPQKTTAKPVPPPVPSTKPSVSQKPMALPVSSRNPQRDSLQNQQHKPVFPLKPVKQNSPVSNKKDDNINRPKKIGKLNTALFESKIPIFAPQLDETPKQAETPSKKIPPTTEKPTRNEPAKPSASQCVAIAAFTNTDQDGLSFSEGDLFDFLEDSGSGWWLVKTQATNREGWAPSSYLEMKTPDNITPIANQTNRPQRRDPPDPPKRPDSSKPAKQFYVAIATFCEDDETSVSFQEGDTIEVLQQDDGGWWMVKVNDETGWAPSNYLQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9F1</accession>
    <name>A0A6P8I9F1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565204.1">
        <property type="nucleotide sequence ID" value="XM_031709344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9F1"/>
    <dbReference type="GeneID" id="116300468"/>
    <dbReference type="KEGG" id="aten:116300468"/>
    <dbReference type="InParanoid" id="A0A6P8I9F1"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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            <dbReference type="ARBA" id="ARBA00004479"/>
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        <source>
            <dbReference type="RefSeq" id="XP_031565204.1"/>
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    <sequence length="717" mass="80340" checksum="523404577CBBF8AA" modified="2020-12-02" version="1">MVCYSDKLPNLAFRWANNAFAYAGRLGRLEVRYHGTWGALCADNIDLEDAHVVCRMMGYSQALGVFKMPMSFSVIKFSLILSCNGNENSTKKCSTAVLNKINSCNTNMESWISCKSSSENSVDADVAVRLVNGTAPNEGRVEVRYYGIWGTICDDGWDLADAHVVCRMLNYSKASWTGPAKVKGSGLILLYDVECRGNENTLGDCRKPGWGQHNCDHSEDAGVKCGHMTEEESSVTARLVERIEKHVGFVEVRYNGTWIPICDDTLDISDAYVVCRMLGYKGAQAPIRQYRQGVNGLWMGGVECSGDEVSISHCYHRGWTNARCRGNYYAGVMCKVTKDLPPIQIRLEERPKPDSGRVAVRYGNIWGSICARGLEMKDALVICRMFGYPGIISWYISQSVNGTIWLSNLECNGTEKSIADCRHRGWGQTTPCTHDSDIGVNCKKADAPRFQINGTNAITKSTVEILLNNSLTIDLGLQSLYQVAVEKRNIEQRLKSYEQPPPFVYNEVNVTMATQMGNDSYITAEIISPIKNLTIGDGQYYHGYYNAPLEAGSMYRVHIRIVTMAMEGEQERVNGHSNFVAFTTKSKTTASVKDVTDQETKKNTYSYAVLGLSVILMLLVCVIVGLIAYCTIKLKNTRKKYKSAKAAELTEFTNPEEPNDQPDFYCKPLDRKYESTEENECCDYENVTGLWMQRYQVPKPVLTDEEKDTDDEDYENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9W6</accession>
    <name>A0A6P8I9W6_ACTTE</name>
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        <submittedName>
            <fullName evidence="12">RNA polymerase-associated protein RTF1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116300169</name>
    </gene>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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        <lineage>
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            <taxon>Actiniaria</taxon>
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            <taxon>Actinia</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="KEGG" id="aten:116300169"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RNA polymerase-associated protein RTF1 homolog"/>
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        <property type="entry name" value="Plus-3_dom"/>
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        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="423"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031564828.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="75614" checksum="CEBFA40E59A58A2F" modified="2020-12-02" version="1">MGKKDGDAKRKRKRAVFDSESEDDESGADLEEEFLSLTKRPKQKEPASKPLANKPSAASDSDLDSSEGSDDEWTMDSETSKGKTTKVKAKKKQGKKRSSSESSEMESGETSSGELSSSSLSSSDEDEEQYHDGWDENLIGDEADRSMLEKMTEIEREQEIFNRVERREALKTRFEIERKLRHAKKKEKKKKKDKEKASYFKGGGIALRKKERKKVIEEKKVKALDDLKAKRSEKKEKKAGEAFLEQKEPLKASEVFTDDEDEDDQDESKSSADEDSYAGSDDERDYSAPVKVSMVDEIEKIRLSRHKLEKWVHMPFLADTIVGCFVRIGIGSHEGRPVYRVAEIRDVVETAKVYNLGKTKTNKGLKLRHGPQERVFRLEFVSNQRITETEFQRWKEECEEHDIPIPNLDDIERKDADIKSAVNYMYKEEDIEKIISEKKKFGNTPVNYAVKKNQLARSKELAEQSGDIEKADKIRQELEDVEEKAEGLDKKRSKGLSAISYINERNRKRNIIEAEKAAAEELRTEEKKDDPFTRRKTLPILVSMAKNQALIDGSFIADPPEDNPVPEPVETPKITRTLESMIPSHSLLDTPIDVTETPVADVNKPNSEDLFSAHNFDITINLNFPLPETRTSATVTQTPNSERDGTPRRSLNLEDYKKRKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA01</accession>
    <name>A0A6P8IA01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 16-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561500.1">
        <property type="nucleotide sequence ID" value="XM_031705640.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22172">
        <property type="entry name" value="F-box_FBXO16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052805">
        <property type="entry name" value="GEF_Ubiquitin-Prot_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46857">
        <property type="entry name" value="EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46857:SF2">
        <property type="entry name" value="F-BOX ONLY PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
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            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561500.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43499" checksum="6CEEA45728D0E6CE" modified="2020-12-02" version="1">MTTRTVDFNSTAYAKTKSFIAKENVASIARAKESRKQVSVPPSGVKSSWTPQKQELNEKLFEERKELVGNWFDRWSDPQRRTVLDILVSKCKQPQLQYIFSLLDAHIPVTHVDFTRKLPRVITVYIFSYLDPRSLCRCAQVCWYWKYLSELDEIWMPKCLKFNWVLPFVPSPFEHGVWKRHYLESVKGLQYVRPKSPPSVTFQSISRETERKSQSLTNLSSTKKAMKKGSSTDLPPWKGTDNKPNEIIRKASREGPLIGCRRCHMSTHTNDDEHSHPENIKKTSTMPKTKPRIRPALASFAPEAESTSTKLDSRTGRPDWAVQSTISPVTAKRPPPPVVRPSAEALGKRREARHPPSQDLFPTQPWARPPDYDSDENSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAD8</accession>
    <name>A0A6P8IAD8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-1 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116300361</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565083.1">
        <property type="nucleotide sequence ID" value="XM_031709223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAD8"/>
    <dbReference type="FunCoup" id="A0A6P8IAD8">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="GeneID" id="116300361"/>
    <dbReference type="KEGG" id="aten:116300361"/>
    <dbReference type="InParanoid" id="A0A6P8IAD8"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000437">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="64"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031565083.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39501" checksum="C3B3274B11A691A5" modified="2020-12-02" version="1">MSAPANGSICNTGTLDAWDWNTTNSTKNHSIEKLAATVSSDSHETDTIVFLVSSISLAVVIVVGNVLIVLAYRSNSRLQTKANMFLVNLAVSDFLVGIVSLPCWVVVQLLGLRRDDSFYEFFITFDIFSGLTSVLHLTAISIERFLAISKPFLYPSIPSRYYKVTIVFAWILAAIISALRSAIPKPWIKFYIPAVLVIGFLGPLFIIGSMYCGIFKIAKSLILKEPGGDERMMDRQNRKSSKKYVIRKERKVAVTVSIITGLFFVSWLPFYVVLLIGVFCFPGCWPKSPFDVLRVIAFSKWMHYGNSAVNAFVYSFRDKEMRRTFARLLHNRFTQFCIEVKPVEEASTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAP7</accession>
    <name>A0A6P8IAP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tenascin-N-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116300506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565243.1">
        <property type="nucleotide sequence ID" value="XM_031709383.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IAP7">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="GeneID" id="116300506"/>
    <dbReference type="KEGG" id="aten:116300506"/>
    <dbReference type="InParanoid" id="A0A6P8IAP7"/>
    <dbReference type="OrthoDB" id="5979006at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF459">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="186"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="270"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="359"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="7">
        <location>
            <begin position="443"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031565243.1"/>
        </source>
    </evidence>
    <sequence length="659" mass="72576" checksum="74EED44CAF7274DB" modified="2020-12-02" version="1">MAGTKRSSWPSSSMIVSFIVVLLCLGEFIRVELLLKNHVSRIRELESTVQTKRRQHVESTTSNAQNEEGQETSRIRRHQTINVNVSSSKIVRELERIQRFALRFCAVTMTDKHCRAGPPGPPGRPGHRGRRGKRGPKGDMGMPGRFGKQGIMGPLGPKGEKGNRGVQGPRGMRGSKGDPGRSITSPDVIIFPSSLVVNEGQTAILKCWASGNPKPVIGWNKVGTSSQLTGDDKLVIPNVTPSDTGSYKCHARNLLGTAQQTVRITVQFRPGILIHGDQIFEKEGNNVTLPECLVTGFPSPNISWSRASKPLPKARTITNGGKLSLLKVRRNDSDTYICQAENVLGSTSRTVQLIIVKLPTFVKKPPTSFRTTVGESFSLNCTARSDPAPRISWRKLNATLPPGRRSEVRGGTLTIRRAEIEDSGVYICNATSAGVSSVEAATQVTVIRAADCSEIYKSGVRQNGVYTIYPDSTGPFQVYCDMTTDGGGWTVFQRRQDGSVDFYRTWDXYKTGFGNLHGEFWLGNDKIHRLTSRTASMLXVELEDWDGVKVYAKYGSFSVGSEGSKYRLSVTSYSGTAGDSLSYHNSMAFTTKDNENDLDHVNGNCAHQWKGAWWYNSCHESNLNGKYLGRVNDNQGIAWSDFRSDLSLKYSEIKLKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB65</accession>
    <name>A0A6P8IB65_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rhophilin-2-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RHPN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562010.1">
        <property type="nucleotide sequence ID" value="XM_031706150.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IB65">
        <property type="interactions" value="1039"/>
    </dbReference>
    <dbReference type="GeneID" id="116297843"/>
    <dbReference type="KEGG" id="aten:116297843"/>
    <dbReference type="InParanoid" id="A0A6P8IB65"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047138">
        <property type="entry name" value="RHPN1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031:SF15">
        <property type="entry name" value="LD12055P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23031">
        <property type="entry name" value="RHOPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="7">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="BRO1" evidence="6">
        <location>
            <begin position="131"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="524"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="623"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031562010.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="76320" checksum="1CA57504884905BE" modified="2020-12-02" version="1">MSHECEDPQMEGTENTEMENLAQKSSNDDVKELTRALDDAEFAFRKSARWRLQHKRQDLNQKIYKQMKLRDGAENLLKALRATNDRRLKKAAKMELNFASTQLNQLREELEGINSAFDVYQFDESMEKQIPMISLGLRETTELNFKVPFMDFIAEHYSEDPEQYEMELQKFSDMRKGICNPNRDEKGIQKLYQYFNQLHFIEKKFFSKKTTMPVYFHWYDALSGLPKIQRSVAFEKASVLFNIGALLSQIGTKQDRNTEEGVRVAFSCFQKAAGVFSYTRDNFINSPSVDMTQDTLEALMSLMLXQAQACLWEKRMQIQDGFQDNIQAGQECAEISQEYNRTFLLMNMGICMDAIPSAWRNMVKIMSLYYKALSHYYTAVGLLKCPTPEMDVTSLHEIIPSLYIPQSNSGNIKNKQAKAHLHTALRNHEEAIRAKQLCRFCRKMVSLQKVLSESRNRSMSKLISMEEEDDFDDPMSPTPVKAHVEQKAHLHAPEFSCAPVEDLFHKLGPVHIFNADSTLSTPRSITIARRGGSFGFSVIGSAPVIVQSAEEHGAAWDAGLQVGDIVIGVNGTDVKWSEHIDVVTTIRKLTDNVTLQIRTPQSLREIAAHCNLRVIKSDSSVSTNDKVSVSSEGSSTSSLHPSSSDAGSNDSEGSNPIKRRKPIFRHSSDPFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFB4</accession>
    <name>A0A6P8IFB4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">LOC116300656</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031565421.1">
        <property type="nucleotide sequence ID" value="XM_031709561.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFB4">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="GeneID" id="116300656"/>
    <dbReference type="KEGG" id="aten:116300656"/>
    <dbReference type="InParanoid" id="A0A6P8IFB4"/>
    <dbReference type="OrthoDB" id="5976751at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 22 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 22 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="27">
        <location>
            <begin position="136"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="259"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="432"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="439"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22 24">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_031565421.1"/>
        </source>
    </evidence>
    <sequence length="715" mass="81135" checksum="46443B8BFC26253D" modified="2020-12-02" version="1">MLADQKKAELVIPDVRIKDAVYYGCTATNRVGKITLDEAFIDVITSLDIINGGENFTAVAEGNVTIRCVASSEITPTVRMLKNGVELQTKEKVSDDKKVVMAELTIISVTTDDSGFYACEATNRQKSVQADVRLVVDVPIKIDMDVTLQDQTFSDELKDTSSEKYRNLSAIFVEELTKXYINETGFERVEVLGFRNGSVAVRFRVIFKVKVQKPEDKPPPDTKVRIANVVVRRVVETQGVVGTLKIKPESVKPLVKPPSPRNLTAVNIKKRQMAIEWKHPLFHDNYDVKHYVIKYKVFGNSWQEIQLNGKHVNRYLLEDLEAGTRYSIQTHAVNHLGEGLPSNVVETQTLSAFWETFAKVFIPLLIIVLIIIIIVLFYLRRRRLRNKKRREMMDKNRHKELLIKEKKINEEDDVMETIELPQRWKEIPRDKLVLDKELGSGQFGVVYKGFLKEKGEDEVVPCAVKMLKPNASQEATRDLFNELEIMVSVDEHPNIVNLLGACTGKDGPLYVIVEFAENGCLLDYLHANRMPFPSANGNIEDVSSLKNQEKIRLAFDVATGMQHLAKFRCVHRDLAARNVLLGKDMIAKVADFGLARDVYEQGFYEKSCTGGKLPAKWMSIEALETLKATTESDVWSFGVLLWEIETGGKMPFAGLVFNDILKALKSGVRLPQPAYCSDEVYSIMRTCWEADPRKRPTFGDLSWKLDNLFIHYLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFD0</accession>
    <name>A0A6P8IFD0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565444.1">
        <property type="nucleotide sequence ID" value="XM_031709584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300670"/>
    <dbReference type="KEGG" id="aten:116300670"/>
    <dbReference type="InParanoid" id="A0A6P8IFD0"/>
    <dbReference type="OrthoDB" id="5971504at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565444.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="36092" checksum="C2168F63E36FF835" modified="2020-12-02" version="1">MWRRIQEEHDLRVNQKXVRQLMKVIDPIGVETRKRHRLSRRKYVAPGPNYLWHADGYDKLKPFGFAIHGAMDGYSRRVLWLHVSPXNNDPAVIAWYYLKYLEQHQQAPRILRCDLGTENTTIEVLQPFFRYDCNDAFAGVKSFMYGKSTANQRIEAWWALLRKSCTGWWINMFKDLRDRGLYNGHDPVHIQCLRYCFMGVLRAELQRTVKEWNSHPIRSNKNGECPSGRPNVIYFSPELYDSENFGITVDVEDVEICLDEYASPPPPDYTDDFLQLLHLLRPFAERPNTVGAACDLYVELIEELRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFR8</accession>
    <name>A0A6P8IFR8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116300754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565537.1">
        <property type="nucleotide sequence ID" value="XM_031709677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFR8"/>
    <dbReference type="FunCoup" id="A0A6P8IFR8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116300754"/>
    <dbReference type="KEGG" id="aten:116300754"/>
    <dbReference type="InParanoid" id="A0A6P8IFR8"/>
    <dbReference type="OrthoDB" id="75950at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="9">
        <location>
            <begin position="156"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="206"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031565537.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="62683" checksum="5354C7A8B5253180" modified="2020-12-02" version="1">MMVQHTRRCREYTGPTPNSVAIRAKPTNKRPVEYLILEGRRRDELRDQAIAETKYQNQCDLKSEWEKATDKRIQRNTIVRRVDRLMQSETFNLEDRRERLREMLLKEEEDHIKEMEAKEETTIERQAKMRERAKFLKQKHEQERLQFVQEKLDQRWREECEELRATLSKRHQDDVFTERSDQIRMKEEQKKREKEIESMYADLWEKDVQAKKLREEQAAHEQMERNRETLRILQLQSEAIEKQKEEEKQLKEMEAAWLAEQQKMREQEEEFLRQEKVRKQQAAKRARDISIRLKNEKEAREKQEELALDMKILEKLLDDTRNEAMEDKQRKKELREENLRFMQYCALNRKEEEEREKALENHVNAEVEKQWAKKMEQYRKERAARKRLMENVMKTRQEQMEERKRIANALKDAEFAEKEAMFQAWQEHERIEKANKERALQKNRDYQAHLSMQIDYQAQMKQKEKDEEREEFLLGQEAEKEYQRRLKEALQRPANKIHPIRLMASHRSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHG6</accession>
    <name>A0A6P8IHG6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase-activating protein 24-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116301229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566115.1">
        <property type="nucleotide sequence ID" value="XM_031710255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301229"/>
    <dbReference type="KEGG" id="aten:116301229"/>
    <dbReference type="InParanoid" id="A0A6P8IHG6"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF24">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="133"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="392"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031566115.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53722" checksum="E567666720D70608" modified="2020-12-02" version="1">MQKAPIXPPRTKQKVVYSGWLRKQGGGFRTVRTRWFEIKGDQLYYYKDRKEPKSPLGIVPLAGNEVIRFPLDPNDPGKYKFEIISGKDKAGRNVTEGHETFVLIASTMQEMDSWISVINRIIYQPFGGGMFGGDLAETIKYEARKGGGFVPIIVDICMKYIRENGLDEEGLFRLPGNMKIITELKAAFNRGENPDISDRDIHTVASLLKLYLRELSEPVIPYDFFEVFLTAAKCYEMYEIDGIISIQKHLQQLPKANYNLLKMLCRFLFEVQEHSDENKMDTRNVAMVFGPNILRSGSEDPQVMMESTGQVTALICILIRQHELFFPPSDDEHTYSRPXVMPDRESKLLIDFSSESPVMQRASAPGASPSGNFNVTENELFQEAISNGPAEEEDLKTQVEEMENEMELQQQQIKELQMDLEKQRKVQEMLLIRLSDEQRARVAAEDRIAKLNEAMDEFIVQNGGFGFGQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHI3</accession>
    <name>A0A6P8IHI3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tripartite motif-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566251.1">
        <property type="nucleotide sequence ID" value="XM_031710391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301352"/>
    <dbReference type="KEGG" id="aten:116301352"/>
    <dbReference type="InParanoid" id="A0A6P8IHI3"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="441"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566251.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="54508" checksum="CD559D475A6262EF" modified="2020-12-02" version="1">MEDDFVSKLEQDVQCSLCNDRLTEPKILSCFHTFXKPCIKRXAELXEKAVNVFKCPKCKSLTPLPDLNSVEDLKPSLLHSRMVKVLEFVESEKXCSVSGSHPPASWHCFECNRSLCDECEKSHSVFTKAHKTTRLNNLKKEDVALMLRGNYGHEHEAIYNFYCNDSKENGEQAKLEVQKTVKRLISSLEESEKELEREIEKKIKKAEQKESKGQVVVGKTLSVLDYVCKVMENGNLNEMNEALIDTAGYDNSIDNPSRQESRFKFVCSKEVHALGNSGIGILKPILTDPVMSLIEVESEDLEALKKSALVVLTKTTTGKLNADPDDVVDVKITPEDGVKIKLKRTTDGKIEVEFIPKVAGQLTAEVQVNGNNVSNSPLVINVKPQKMEITSEFKMKGIQTTSSDFTGIAVNKENSRIAVADKSSHCVYVCNTDGDLLLTYGSRGNGQDQLDNPHGLAFLNDTDLVIADFGNNRICIVNTDTGTLIRCFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHQ2</accession>
    <name>A0A6P8IHQ2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116301438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566357.1">
        <property type="nucleotide sequence ID" value="XM_031710497.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IHQ2">
        <property type="interactions" value="1320"/>
    </dbReference>
    <dbReference type="GeneID" id="116301438"/>
    <dbReference type="KEGG" id="aten:116301438"/>
    <dbReference type="InParanoid" id="A0A6P8IHQ2"/>
    <dbReference type="OrthoDB" id="5919182at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031566357.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19410" checksum="86D66FB60A9012BB" modified="2020-12-02" version="1">MPKGKFPFRRTFEFLSAGRVILKKDIRSVMLSYTHKDESKGLRNFIYKDLPQIQFKNNAXQFITWRNRTELNRIVICLGDGRKVLIDVENKKGPEILDIFDKVAGATESELQIRRQPKYPGRINPANFGKYGHCYCICEKPGQVPCPSRVPRPETRKTKPWQEKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHZ0</accession>
    <name>A0A6P8IHZ0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein KRI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116301271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566163.1">
        <property type="nucleotide sequence ID" value="XM_031710303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHZ0"/>
    <dbReference type="FunCoup" id="A0A6P8IHZ0">
        <property type="interactions" value="1184"/>
    </dbReference>
    <dbReference type="GeneID" id="116301271"/>
    <dbReference type="KEGG" id="aten:116301271"/>
    <dbReference type="InParanoid" id="A0A6P8IHZ0"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="4">
        <location>
            <begin position="460"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031566163.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="80098" checksum="E71438A31A00F074" modified="2020-12-02" version="1">MKTRGVEVSVKAKYGERDYQESDSSSSETEDEDAKELTAQKEKDFLKVLSLLKKKDPKIYDKGVTFYHQESSSEEDEGEKEEKPKKPVFLKDYERERLLEKGSKAFISDDESNGESDDASEEKGVKDLTYSEEQKALKDRLKAAITESDEEDGGFLSLRQKSKEEKQKEESDYKEWLKGVKNGSSSHDTDLETLQQFWSNPSLDQDEQFLRNYILGKGYIDKDVSRIPTYNEIVDDEKEDEEELEKQEEFERKFNFRFEEPDAEFVKTYPRTVNASVRQKDDKRIEARKKREERKKKEKEQKREELKRLKNLKRKEIQEKLEKLKEITGNPNVGFTEDDVDDDFDPKKYDSIMEKVFNEGYYEDEEGEKPTFDDGLDLEEEENWDEWVGPSQDGNYDNEEYNDYNENHNDDYYDDCNFNMDADYDPSMETQQPKRNRKNPSSKLTRALNQKKPLFDPNEKTFEEYFDEYYKLDYEDIISDLPCRFKYRNVLPNDYGLSTEEVLSRPERELNQWVSVKKMSQYRTDEEERRDIKKFLKFSRDERRKQRIFSSTATASEISTPETKQSTIQKDPTEQKTNFTITKQERKIPIEKQITNDTKPQQKQETKTERKEKGKMSQLKRMGWKRRLTPKEAKDQAQKKKLARQFKGAKREQLAGLTVDRLAAYGLRKKRKVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIL6</accession>
    <name>A0A6P8IIL6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116301585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566525.1">
        <property type="nucleotide sequence ID" value="XM_031710665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIL6"/>
    <dbReference type="FunCoup" id="A0A6P8IIL6">
        <property type="interactions" value="2336"/>
    </dbReference>
    <dbReference type="GeneID" id="116301585"/>
    <dbReference type="KEGG" id="aten:116301585"/>
    <dbReference type="InParanoid" id="A0A6P8IIL6"/>
    <dbReference type="OrthoDB" id="18145at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026164">
        <property type="entry name" value="Int_cplx_su10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21045">
        <property type="entry name" value="INT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02106">
        <property type="entry name" value="INTSUBUNIT10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031566525.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="86905" checksum="31FF0ABCFC933E4A" modified="2020-12-02" version="1">MAATSENIAVNRTGCFSTAEWLVERARQSLKHKDLYEAKSWLLTAKTLYPRDFHVQHEAYNIERNAKKVKESAILFYDMFVQFPNESLLWEDIQNITEALERNEIDPQGVFLKEMFNSLPQDAQREILLQAAGRCKDCIEKCRMMLLLMRRFPDAIPKNGITLTEMLIDAENSEYPTNPLNQYRKLLVNDVLPHLLTSERVVITENWSAETEKEGRQPGISQPTVLKWLELSIQFYSFCATFLPNPVEQQLLSPTASSGPQVKDTREIVSSVQEGRGPWGSLFDIFCLVAKKCEWTEILRTQDMLNPVVHRSIKERWLCISEIHQWLKKAAKHGTTERVINESQEKTGVFYAIIIIFFQSVWEYCKVVNKLDSGVNTSLSSSVPLVLLEDVGADKTSIDGWAGGASSEGSSAPKKKKKKGGTAPSSPSKEDSRAKQTATITVNKSCGNVSTSLPDEFVVSVDTWHILNTHSDYKSGFTRVLAEWHIDQWIWMESFKVDRMVYKAKYKKVVDFLKEQKGFLESDPFAQQEVFIRGSLQMSCCYFYLGEYRNSCAEALNALRFFSSQSINTTDVKSLKRGISTMQGSSNRDTNAMGPSQLIFPGRVLQLIPCTEGEALSFCVRLLITCFKQKISHETRSGDLVGHMIILLQYDWPKEDQTFYELLERIRSHGGLTYRKFFNYIVNIDILEEFAYLSSEGVLKLELLPKSTSTSRSRTVTRGVNKGAKEDFRATLEKQVSRSEENIEVILRTFLEEERDSIINCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJE6</accession>
    <name>A0A6P8IJE6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116301848 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116301848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566862.1">
        <property type="nucleotide sequence ID" value="XM_031711002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301848"/>
    <dbReference type="KEGG" id="aten:116301848"/>
    <dbReference type="InParanoid" id="A0A6P8IJE6"/>
    <dbReference type="OrthoDB" id="10285525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028477984" evidence="3">
        <location>
            <begin position="27"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031566862.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44264" checksum="DBDA63AA497E1E7F" modified="2020-12-02" version="1">MESVGFFYILFFLTILSILGISKSSSQHNNISCNATVDCKVNGNLSYFCCNNICRFDSDCRHNSSSEESSMNDTKPVYSGQSNSNVNLNQSRRYDDFCSKDNDCNSSHRICISFECLTTSAKENIKDCQRCVLIDCKDGRCYNLTSSVVPTSKPGEETITTLQLVLLFGSMGGILIFIIIVYCVKTFTDNRRRQYLLKHGVWDNPPNKEGKDKDDKGDGDTKPDXIRQLRKLEVPTITLETETDFIRKKKNKETSKDEITDTEGLHDFAIQDSKQQKVKTIADQGISDTNQHVNPSTNATKHPYCAQKEIGETIGSPKNIRMPTDWDNEDEKTPLTESPKQKRFANLMKTRNNSPTKIIANGAPDNSPKFGKHKHNSPSVQLCEPENFSDFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJU3</accession>
    <name>A0A6P8IJU3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="12 16">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116301958</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="function">
        <text evidence="14">In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:55989"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="12 16"/>
    <dbReference type="RefSeq" id="XP_031566990.1">
        <property type="nucleotide sequence ID" value="XM_031711130.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IJU3">
        <property type="interactions" value="1233"/>
    </dbReference>
    <dbReference type="GeneID" id="116301958"/>
    <dbReference type="KEGG" id="aten:116301958"/>
    <dbReference type="InParanoid" id="A0A6P8IJU3"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000009">
        <property type="entry name" value="mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000001">
        <property type="entry name" value="Mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="19">
        <location>
            <begin position="94"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="18">
        <location>
            <begin position="335"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031566990.1"/>
        </source>
    </evidence>
    <sequence length="814" mass="93729" checksum="9090DCBA23715CD6" modified="2020-12-02" version="1">MARSRRGKQASDPSPDHKEPRPKISKSRGRSSRSSKDGVLSPTIVLAILIIVPVCIAASYGGYAFYNYRRTARLYTPLDAEPVVDRSKADPRRFWGSYRXNLYFGMKTRSPASLMPGLMWFSQFPHDGQLSIRHTCEQGDRLSKYGWLKHDGVNFGTQEIVDDDFILMTDFVKQAGGDHGGDWTARISGRKREQGNPNQLVSVLFYTTHDNPIQLKPSLGRNSLTELQGESPELGKFKIIFPKPNNKVILSNFLATHTPNIHSIKDVVMQSLGYIKMKKDLKLIGLQGILPKRDENQRELPTNLYVQQWTFQLPFXMEVIFESASFTSRTRRLSGNIFSDAFRKFSDSFDKKFEETFPLESKSFSEEERRFAQAALSNMVGGIGYFYGKSRVVSRYLKKPVEYWESALYTAVPSRPFFPRGFLWDEGFHQLLISQWDKDISMDIIGHWLDLMNIEGWIPREQILGDEARTKVPDEFVTQHNENANPPTLILPIKSMIDKGVLDKQYLVKIFPRLKAWFHWFNTTQLGRLPSTYRWHGRDAKTDRELNPKTLTSGLDDYPRASHPSDDERHVDLRCWIAFAAGLMADIATAVGKDPEVYHSTNAYLSDATLLDHYHWSSKAHMYSDFGNHTKLVKLTHRASQPGGPTRVVRVVTSRTGPVLRFVNCFGYVSLFPFLLXILKPDSPRLDKILTDLKNPDLLWTDYGLRSLSKSDPFYQKYNTEHDGPYWRGSIWINMNYLSVRALRHYSHTEGPYQEKARSLYSELRHNLISNIFRQYQMSGFIWEQYDDETGRGKGCHPFTGWSSLVVLMMSEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKH2</accession>
    <name>A0A6P8IKH2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116302196</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567289.1">
        <property type="nucleotide sequence ID" value="XM_031711429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302196"/>
    <dbReference type="KEGG" id="aten:116302196"/>
    <dbReference type="InParanoid" id="A0A6P8IKH2"/>
    <dbReference type="OrthoDB" id="6078042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14389:SF3">
        <property type="entry name" value="PROTEIN FAM111A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14389">
        <property type="entry name" value="SI:CH1073-475A24.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="69"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567289.1"/>
        </source>
    </evidence>
    <sequence length="1351" mass="153639" checksum="126F14EAF0FBCC82" modified="2020-12-02" version="1">MAAHYVTGAKTDEIFTNLTVYYADKKQEKKEQAKDLGRSELLQGYTKRTMDRKVEKYENVFNDMKGENPKLLLIGKAGIGKTFLCEKVIRDWSMNRIFQNENTPNIQFAYLLKFRQLSKQGDKEINLQELLNCSPLLDDNSVIDDSLFEHLIQNPSKVLIILDGFDECSEQHRKQIASDFEKKYPNDSKKEMPIPALCSKLIRGKLLRNAVVLVSSRPGKAEELGKIKFGRYVEISGFSPEQVIEYVDKYFGGPGKEQTRNDDTIPSEIRARGPEALKAYEEALESGKTKNRRLLIMVVGPARAGKTSLLKSLNGEKYDPKEDSTDGIQLQRTFCKSQENCWSKESTKGISYADCMADIIHKNLQGGDDSEEIHDKNFAKARLKESTEKSVESSESLSKNDDDDRDEDHDNDDDAVEDDDVDEDDEADDDDDAHGNDDDKMNAIKVESEEMNEEANEERENQEYISEKSAANLPKPIEEKLIKLMGSKMSDKTNRENEVYIKSLDFAGQAVYNVIHPIFLTSKAVFILVYNLKNVPHDLMKSIVQEDGAERELVDPFEMTNMENLELWLSCISSYTDIQRMAKIDELSLPPVFLAGTHADRFDGNLEAARKIIREIYKSLSPSKNPSGSHVVRNEIYTVNNSVSGNGEINDEVVRKLKADVEDLSKSLPHMNEDIPINWLWFEEELSNLVENENKKYITIDEALKIVNECKVNTSAESKEFFTLLNYLHDSKTVIYFEETKKVFIDTEWLVKVFTKVIEVRPVEKRDGFDESWDKLEEKGVLDRALVEHVWKGLVDERNTIDSLLLIMEKFSLICRWNTSEGEEVYLVPCMLCNSEKREDIAKCLEHEKSSTMVIRFNTSHVSLGIFPRLFVAIAEELKKIWPNLEKPELHKNFCRIFEIGKERNLDICIIQSSFQTICVTVCNIQNIDGQQVTEFCQDFRKLLDQIFDEMWRNFPWMQNMTFEYGILCPVCTTSSNKCKSHGMEGCTQDTCLHFVNEKELSVDTPKCKKYVANLDNVIEEKAYVYWFPRQAHQLQVEKFGRCGNFASNHKYQVPVTDLQETLNGMKPSIGAIIAINISNVPACGATCFRIGTKYVITNKHVIDDLCKSGIQSWSSCYVDFNYNERGQPGYRVDFAPNPVSFICEELDYVILEMCSKNGNRLPPSVTDLGYNIAPPGHQLKSGEYLTFIGHPGERRKQIDVTCPIKLQQDIQKDLHKYDASTVSLILEACNHPDHATYDVSTFFEGASGSPGILMEKKLLVVLHKGGFENRALEFGILMSSVVKDVMTKIGNAPIQNALDDIFGGSTSSIFDQRSLVPLSESERNTPTQILGEYPTPPGGMTCRNIENLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILM6</accession>
    <name>A0A6P8ILM6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116302533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116302533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567714.1">
        <property type="nucleotide sequence ID" value="XM_031711854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302533"/>
    <dbReference type="KEGG" id="aten:116302533"/>
    <dbReference type="InParanoid" id="A0A6P8ILM6"/>
    <dbReference type="OrthoDB" id="5959102at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027833519" evidence="4">
        <location>
            <begin position="25"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="5">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="5">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031567714.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50372" checksum="368A1CEC12817978" modified="2020-12-02" version="1">MALNGKIFFTLLFVVLCCYGHGSSFVCQKLDNQLQQLCSKINGGYNFTASFKSVNGVSYQDGVYSKVLHLQRELKTCSIVSELMICSRFVPKCVEGRSSPVLPCREICEQFVEQCGSKLEERNLKVLYATICNELPHSRGDDGVCIEPKGLEKQGKHKKLAISFNCSSQTIPACIXGNYSQLXEDIRTKLTKGLSHSQXLIKNGCAEYLKRYSCYGQTTPCYMHNRLPYRPCRWHCELMRKECDREISMFNLSFPLCDELTEKDRVGDLCRMDSWPVPWPNITKKKEVQETWKTCYCNSGCGQIKKTCETKGSCFIQSQFSIDYGYTYTTQVCIHPGKQRDFICNNTKNYMYAKCCDQNYCNKHLEGISRASTTTAKPTSIPITAVANVTSXAKSTSNPSITNNMAPTGTPPPIIVATTNNSSASTGHDGIYIITIRAALASVLAITFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILX0</accession>
    <name>A0A6P8ILX0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116302594</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116302594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567787.1">
        <property type="nucleotide sequence ID" value="XM_031711927.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ILX0">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="GeneID" id="116302594"/>
    <dbReference type="KEGG" id="aten:116302594"/>
    <dbReference type="InParanoid" id="A0A6P8ILX0"/>
    <dbReference type="OrthoDB" id="6022335at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF459">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="178"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="262"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="351"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="7">
        <location>
            <begin position="436"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031567787.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="71921" checksum="B0DE22437DAC4BC1" modified="2020-12-02" version="1">MGDSKRTSWPSSSVTVSFIVVLLCLGEFIRVELVLKEHVTRIRDLESKVRSNRQQREEDTTKQALNVNTAKLDTSRVRTRRNASRPSDLEELQKLHSRLCATIVTDRKCRAGPPGPPGRPGPRGRRGKRGPKGEMGIPGKKGIMGPPGAKGKKGNRGLQGPRGMPGSKGEPGLSVSSPDVIISPPSLVVNEGQTAVFHCSSSGYPTPEIGWSKVGISSQLTGDDKLVISNVTPSDTGSYKCHARNLLGTARKTVRLTVNFRPRVSMKTVPLFAKEGDNVTLPRCHVTGSPVPTIMWSRAAGELDQSRTISNGGQLSILNLKQQDSDIYFCRARNLLGSSKRNIQLMVVVLPKFVPKSPKNVTKYERETFSLSCSTKGTLKPVISWRKVNGTLPSGGRSEVRGETLTIRRVEIEDSGVYICTATTIGIFKQKADTQLQVITPAADCSEIYKSGVRQNGVYTIDPDXTGPFQVYCDMTTDGGGWTVFQRRQDGSVDFYREWDEYKTGFGNLTGEFWLGNDKIHRLTSRTASILRVELKDWEGVKVYAKYGSFSVGSEGSKYRLSVTSYSGSAGDSLTLHHNGMSFSTKDRDNDESSSTSCARKYSGAWWYTKCXDSNLNGKYLGNFLSLKGVVWYYYKNNMLSLKFTEMKLKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM70</accession>
    <name>A0A6P8IM70_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuronal pentraxin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116302685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567892.1">
        <property type="nucleotide sequence ID" value="XM_031712032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM70"/>
    <dbReference type="FunCoup" id="A0A6P8IM70">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="GeneID" id="116302685"/>
    <dbReference type="KEGG" id="aten:116302685"/>
    <dbReference type="InParanoid" id="A0A6P8IM70"/>
    <dbReference type="OrthoDB" id="5946182at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF161">
        <property type="entry name" value="LAMININ G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027829248" evidence="7">
        <location>
            <begin position="25"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="9">
        <location>
            <begin position="158"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031567892.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40730" checksum="231948BB0E412741" modified="2020-12-02" version="1">MNSTVKVFMIKWLTMILYAAATNAKCNSSSAIGYMLTGHVYRDFSAPEPLQCYSACKEEEPQCRSFNFHADKRICELNNHSKESRPSNFVPRDVTVYFHSCYRDGLGQTKALAANSCAEILEYEDSVGDGWYWIRTDPARNESAEIYCNMTNGGNMSSSFDLIFPTTRNTTNYAIIDTTIGTLSAFTVSLWLKTTEKILAPFSYAVPSQMNAILLIIDETGFLRFLVNNNQLDGQVRSLDDNAWHHVAATWESVTGHAQVFIDGVLTLNKASISLNTNIAAGGKIVLGQDQDTMGGGFDILQSFAGELTHVYLWDTVLSADVIAQMSRVCKEFPYPGHVVGWKDFDGSLHGEVLRRNLSRCKLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMC3</accession>
    <name>A0A6P8IMC3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptotagmin-15-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568156.1">
        <property type="nucleotide sequence ID" value="XM_031712296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMC3"/>
    <dbReference type="GeneID" id="116302894"/>
    <dbReference type="KEGG" id="aten:116302894"/>
    <dbReference type="InParanoid" id="A0A6P8IMC3"/>
    <dbReference type="OrthoDB" id="10259057at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF227">
        <property type="entry name" value="SYNAPTOTAGMIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="67"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="209"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568156.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39942" checksum="4056B5063E923BD9" modified="2020-12-02" version="1">MGSEFSMHKRKEYNELSITEPVEFSVPKPYTPSYRHSLLKMIGEIDKDIYSETLDYRQLAPPSKALPLGTLSFKVEYESYEEKLTIHLVNAKRLPVRHHVTKVGEDVEYNPVPCDVKVLICLLPGQNENLESSVKQDNRDPVFDELFVINISKQDLRKSIVRLSVFDSRRLHHLCPIGHALYSLKAQDLDGAIEVQREIKPQSQTDGHSRGQLYLSLQYLSSQGRVVLKIIQAQDILHFEKACFKEYYVKVCHIYTDRKVKTKRSSTVEGTRNMVFDCSFSFPISVGDLSESCLVVSLVNYDMFRGSRTTGRVILGPYVMEGEHERSHWGKMVAVPNELVSQWHGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPB7</accession>
    <name>A0A6P8IPB7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Exosome complex component 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC116303017</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Component of the RNA exosome complex. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6 (via its N-terminus). Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. The RNA exosome complex interacts with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with MTREX; the interaction with MTREX mediates the association of MTREX with nuclear RNA exosomes. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with ALYREF/THOC4. Interacts with DHX36; this interaction occurs in a RNase-insensitive manner. Interacts with NRDE2. Interacts (via C-terminus) with USP36 (via C-terminus); the interaction is facilitated by the association with RNA and promotes sumoylation of EXOSC10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568315.1">
        <property type="nucleotide sequence ID" value="XM_031712455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPB7"/>
    <dbReference type="FunCoup" id="A0A6P8IPB7">
        <property type="interactions" value="2912"/>
    </dbReference>
    <dbReference type="GeneID" id="116303017"/>
    <dbReference type="KEGG" id="aten:116303017"/>
    <dbReference type="InParanoid" id="A0A6P8IPB7"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019219">
        <property type="term" value="P:regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000022">
        <property type="entry name" value="Exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="13" id="KW-0271">Exosome</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="HRDC" evidence="24">
        <location>
            <begin position="485"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="701"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00070703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_031568315.1"/>
        </source>
    </evidence>
    <sequence length="819" mass="93896" checksum="A5CCFC5106966AF5" modified="2020-12-02" version="1">MADESKEETEREIPGIVDLQAFSQKALRYLVGCTQKANALPGPGEDHDFYYSFSDFREFRKAQGTRLLHKTSDLLRHFHIQCGWPKKGQSSDSIDHEDLFENLVEANDIILEEVDTKLDEASGLSKNKKPVMNESVKQSKPVVSSWNRRSHGGVKDSPVRLLLAKNILRPQIKFKDKIDNSNSPFVPIIKYKPNAIKKLQIYTPSSPQPEDLSIPTAIADFVHQQRMISNTTTNRICHPYQHELEVFEPPENQLKEAKEELYKGLEETPYTYVETVEQLEELCQKLSSVTEFAVDLEHHSYRSFQGFVCLMQISTRDHDYLVDTLELRSDLSILNESFTNPKILKVLHGADMDIGWLQRDFGLYIVNMFDTGQASRVLNYERFSLSYLLKKFCGVTANKQYQLADWRIRPLPAEMIQYAIEDTHYLLYIYDRLRNELIKSGNAQNNLLMSVYQRSKAVCLKKYEKPLFTKESYLNLYKKQRRPLNPQQLQVFQALYEWRDTIARQEDESYGYVLPNHMLFNLTESLPREPTGVLACCNPVPTLLKQYANEVHQIIQDAKERSVTVTEENISSTEATPMETSSRSPVVARLDVKETRSKSIERASQYASQVSTTPRPVKAYIPTGPQVKTMKPSISIFDYPQKAGPHNEGLEKAKEIMAGFVNPFKVVLPDLEAADVGNKNRTEQSKASIDKINENWKKVSSGVLEETSSSTQGTKIVNNDSDHEDSTPLRQKIEGKKKRKRKKKNETQEGDIPSTPIEKKIKSEDVDEEDDDDRNPSYEAITKVGKEFVPFDYNPTEYSKLEGTDHFFFALGVRITVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPM7</accession>
    <name>A0A6P8IPM7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase/reductase SDR family member 7-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569006.1">
        <property type="nucleotide sequence ID" value="XM_031713146.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IPM7">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="GeneID" id="116303579"/>
    <dbReference type="InParanoid" id="A0A6P8IPM7"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05332">
        <property type="entry name" value="11beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569006.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37325" checksum="F6EBCD2AB466D839" modified="2020-12-02" version="1">MKYILAVLVVFVSVFGYFFWYHQDADLTLLFYEKFGREPCSVLDGKVVWITGASSGIGEYLAYELAQCGCKLVLSARRKHELXRVRDKCAEIAIQHHKSYDKNKDILVLPMDLKEFSSHRNLSQQVLSHFKQIDVLVNNAGRSQRGWMKNMPLEVEQDLLDLNLVGTMSLTKAVLPHMLERRAGQIIVVSSIMGKFGFPYESTYAASKFGLHGYFNSLRLELADTDINVQVVCPGPVKSNVAAYAITEEKDKAFKDTDGYTDQGKRMPTERCTKLMVVGMAHNMSEIWISIQPALTFTYMSQYMPTVFDWYSKARFLDIMKAMFIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQF2</accession>
    <name>A0A6P8IQF2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116303712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031569159.1">
        <property type="nucleotide sequence ID" value="XM_031713299.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303712"/>
    <dbReference type="KEGG" id="aten:116303712"/>
    <dbReference type="InParanoid" id="A0A6P8IQF2"/>
    <dbReference type="OrthoDB" id="5978482at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="442"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="717"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1241"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1090"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1201"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569159.1"/>
        </source>
    </evidence>
    <sequence length="1357" mass="155471" checksum="CD235D506D10E72F" modified="2020-12-02" version="1">MARGLHHRGSSTDFTSSSEDEGCTKRKKKRIKNIVNIRGKENHVAVGNGANVSTTAESAGVTQNSFDVVEILKNPTTLLEAVAKCRGTEKDKIEKNILQHLLPEIENHAIKAASSCNDALELLARFCSPELKSPRLTIHSLRIMKRLLDLEFGSCESANAHIIEVERILRRSLVDGSFAENLQHIQRCRLEVYNSILALILLYLAKGHLKPPYINKTEKEEIKQTVTKNIQKTLQRNPRPKKDRWRFSMETVLNLIERLFDYNKLSRMTKLLDLCKDITLEAFLKKLQCAESSSVDYFVILKMLHGKLCTSNADAYQIIEIIIKNHDVFSKQWQRRNEDWKFSLLACQTLLHTINSTKLSKATRIKAAHCLASLMATKVYGKSEVIRNIIENHCIKTSFARDSKSRKVVIERRLKPELLDHIPLERDVMIKQICKIYESKGLECIEIIDEDENRVIVRGLYDYQPVAITVAIINPIKNLYADQDQDLSPSEKHLQNETKVLQHLNQTPNKHVLMVHTADTKTRPLHMICDYMPKEDLLHFLRVCKEELEIPTYRQLLNVCLGIANCMNFIHKKQVIHNQLRPEHVLLDDNFNVRITGFCQAKILSKNEMERGIHGEKLDLEDPSIRFSAPECLEDEPLFSRESDIWAFGVLMYVVFTCGGTPYANVDTKNIHQHVLSGRTLTKDMGDEVFLLIQKCMGKTRQDRISSFQKISEELQKLLAECDGKGADERLRLISEPLPKEDKDIDVMKNTPNTTKESLSLVDNSKQHLEKLRLLDHTHLARVVEDRKTKSGRVIAYENCEGPSLRHYILSNKCTPEDVIEFAAQITEAINYLHQKNIVLCVLNAESVRVVKKNHVKIFGLHFSRSILPSCNQFNTSFGVVNGEVHPDVYRWCAKEVIQEGIFSTAGDIWSLGMTILEMFLCLAKDADTAKPFSQYSNEEILGALKKNCRPFQPVLCPDWVYVLVTQCWCLKTTERASSLSVLDCLTQKCPWKSYLLQRWIKQNEIHENWPNLNVVQQLDETNPISRQDVESSVSEEFAGSHIYDYEGPFWLKKFKDLVISGKRFLMPSSRPPRSEQRPRLPNSPQETPEDIKHKNQKGKDEDDCDDTYDLPRLPEYEVTCPPRLRSASFPPLSLPPNSTQETITDIRQKEKKGEDDDTYYNIDDMTKLPEYKVTACPPRLRSASSPPLPWPPNSTQETITDTRQKEKKGEDNDIYDDTNDRPRLPEHKVTACPPRLRCVSSPLLSLPPNSPQETPTNIKHKEEKGKENDIYDDTYDRPRTKCLHGNSDQECYTPYLEPDESYQGLSYSTENGYMSLISNSSERIFDVDVAGFHMASTNNGAANNMENQKPVFLMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR13</accession>
    <name>A0A6P8IR13_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">High-affinity choline transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116304031</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569536.1">
        <property type="nucleotide sequence ID" value="XM_031713676.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IR13">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116304031"/>
    <dbReference type="InParanoid" id="A0A6P8IR13"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="16">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031569536.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="60033" checksum="09AC6D4A86762E92" modified="2020-12-02" version="1">MAVFIAGVVGIIVFYVIILGLGIWAAQKKKQGEEETILAGRSIGAALGTFTLTATWVGGGYINGTAEAVYDKGLISAQAPWGYATSLALGGMFFAKIMRRRNYVTMLDPFQEKYGTXMGGLLFFPALLGEIFWSAAILSALGSTVSVVIGLGKQLSIIVSACIAVLYTLVGGLYSVAYTDVIQLLCIFIGLWLSIPFAMTNKAVTKISTTAPMWMGEWPVNYGYWLDHAMLLVFGGIPWQVYFQRVLACKTPAKAQFLSFAGAFGCVIMTIPAVLIGAIGASADWRQTSYYDAPINVTLTNNSDPLKPHGLLILPLVLRHLTPNYIAFFGLGAISAAVMSSTDSSILSCSSMFSHNIYKAVFRPKATSRELLWVIRVSILVVGTLATLMGLTVDSVYSLFALCSDLVYVVLFPQLCCVIYVQHTNTYGSLAGYXLGLVLRVLGGEKLIGLPPAVKYPYYSDVYGQMFPFRTLAMACSFATILVVSYLIRYLFKKEILPMSMDFLYCFREYDLKHDKEPNIVSAQTKDKFEMPELGFSNLAESSVKLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRN3</accession>
    <name>A0A6P8IRN3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Decaprenyl-diphosphate synthase subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569025.1">
        <property type="nucleotide sequence ID" value="XM_031713165.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IRN3">
        <property type="interactions" value="829"/>
    </dbReference>
    <dbReference type="GeneID" id="116303593"/>
    <dbReference type="KEGG" id="aten:116303593"/>
    <dbReference type="InParanoid" id="A0A6P8IRN3"/>
    <dbReference type="OrthoDB" id="9983019at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569025.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44097" checksum="2A00607E829D7DC2" modified="2020-12-02" version="1">MRSDSARQIFQRSGRFLGHPRERCPRLLPSRLFPSRLLWSARKDDLTQALSEAEKLVGYPTSFLSLRCLLSDELSNXAMYMQRLVGSKHPLLKTARGFVYDGHYGMQTRGLLVLLVAKAAAPYLSSDDVSIEQEAVSGIYSGQRQLAEITEMINTAYLIHCGVVNLESLSPLVKLKDMEFGNKMSVLTGDFLLASACTGLARLNNTHVVDMISXVIGDLMEGQAMKNHRSVKDLSLEFWRQVVFKSKASLLASSCQAVLKLMNHSSQLQEKAFEFGNNIAFAHQLKDESQSLQDPQASININTVPVILSLHKKKVKDLVETLIRVKSEDDIEAYEEQSKELHQYIDKDSIARVQAMMVDYSNKAFIALKGFPPSETRRALENIVNTVSHTYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS95</accession>
    <name>A0A6P8IS95_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569767.1">
        <property type="nucleotide sequence ID" value="XM_031713907.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116304212"/>
    <dbReference type="InParanoid" id="A0A6P8IS95"/>
    <dbReference type="OrthoDB" id="5988542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="4">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569767.1"/>
        </source>
    </evidence>
    <sequence length="750" mass="80578" checksum="F18F1575DA41B154" modified="2020-12-02" version="1">MKAEKEENIDFHGPEKSKALHKSCKVKYTIVAVVSVTLLVAAVSLLVAFWPGKHKVSKCLVEVNLEEGDTLMYRVDQSFEVKEKDSQKETISSTVGFQVVNKTSYAYWFLLKINTTFKDDDEEVKSAITGYFRVQLPSTKDYSEDTGNDDTTELFELHGYPQTDGKFVRYLHGILYQLLPAVRRDLYEDVDGQTDQNVKPENSPLFPGPVRMHRQANTKEIDDVLVKNHFNQSDLVNXSSDMDIDVKYNDSATINKTNGMVSESNXYVSEELHFGEPIKTKDGHDVTTMMVNLYSHVTRIEMDSAYFVEEEIKALKIDSFVMLVVPTEESTLDDTLDGQRLSTQEPXTVIRRNRRAVGSDSNRTATPYPGGNVGGGGGGGNGTVGSIGGGGGNGTVGSIGGDGNGTVGSLGGDGNGTVGSIGGNGNGTVGSFGGDGNGTVGSIGGGGGNGTVGSIGGDGNGTVGSLGGDGNETVGSIGGNGNGTVGSLGGDGNGTVGSLGPKLFLRRLLDLSLAMENTFSLFDKTLLGIRTKGEGSTWLKTTAFDWKNGTKKWEMGTDLYVTLGSIRKNIYRVKYSNEEIENGIGREVGMSWSKGIPPICFSSVLIVSLCAEFTLNVDFNIKPPKLLSQETSLSPPKIALQVEAFAEVKANVEAYASALVVRAGVFVDGTLVRVTVPTKLSYSAVKPANQKWCLASNANLTALELHAGLFYQRRICRFIFMCRWGTRNTISSFGTWAALSKDFKLYGICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISY4</accession>
    <name>A0A6P8ISY4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570094.1">
        <property type="nucleotide sequence ID" value="XM_031714234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISY4"/>
    <dbReference type="FunCoup" id="A0A6P8ISY4">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="GeneID" id="116304491"/>
    <dbReference type="KEGG" id="aten:116304491"/>
    <dbReference type="InParanoid" id="A0A6P8ISY4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44207:SF1">
        <property type="entry name" value="SURFACE ANTIGEN BSPA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44207">
        <property type="entry name" value="SURFACE ANTIGEN BSPA-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570094.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24460" checksum="C7C2585F3F61028C" modified="2020-12-02" version="1">MIKDCDNPIFAKEVISQLEDAKLDTNAAEPNSCSGLTPFLCACMSRSMELVEYMLKHGANINSQTACQDGPLHIATFACANQNSKESFDVLAMLIKTGCDLNSKNWLGNTPLCIAASYDRKRLIRYLLFQGADPSICNKNGVYPIDFATNAGNTRIASLLAINLPNPYVWDFIEPHTPPRIKLGLQTPSKQHLVQSSFNRNKRKLNTFRTPRPIRTQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITZ9</accession>
    <name>A0A6P8ITZ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570392.1">
        <property type="nucleotide sequence ID" value="XM_031714532.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304750"/>
    <dbReference type="KEGG" id="aten:116304750"/>
    <dbReference type="InParanoid" id="A0A6P8ITZ9"/>
    <dbReference type="OrthoDB" id="10358530at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570392.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26871" checksum="907309CCB4B4FD1A" modified="2020-12-02" version="1">MLVLLISVIFSCVIGIFLIMWSAKQLLLGGLAVSGVAAAGYFAYRYYKNRNTRYVDDTKREDNEETNEDGDGETQDTQENRAKHTKGGEQVTEVKREENEDGENRGENGRELQLNNQTKDDFVNNNELTKACSNLNKEAVRKASTLRPCPRPKFLQHVKTMEELEMTFEALSAYLFTQNRSEEELKEAEKELGWAWXVAVAFKNRLPQHVPLMDGCITDDDGWLPLQDENGMQSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXA9</accession>
    <name>A0A6P8IXA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC116305930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571794.1">
        <property type="nucleotide sequence ID" value="XM_031715934.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305930"/>
    <dbReference type="KEGG" id="aten:116305930"/>
    <dbReference type="InParanoid" id="A0A6P8IXA9"/>
    <dbReference type="OrthoDB" id="5984501at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571794.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="30456" checksum="A67D8E7C81AF17C8" modified="2020-12-02" version="1">MGDQFRTDVKLTIKLFNCLIKPILLYGSEVWGVDKKKNLNGDPTETVQVTILQNAAGLQYTYLVPYIYLVPYTYLVPYTYLVPYTYLVPYTYLVPYTYLVPYIYLVPYAYLVPYTYLVPYAYLVPYTXLVPYTYLVPYTYLVPYTYLVPYTYLVPYTYLVMQCAAVFHTRKLRCPDSSFSVWIDVGHLILWECKPVLAYIKYLVPHMKYLVPHVKYLVPFIXYLLPYIKYLVPHIKYLVPHIKYLVPDIKYLVPPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXM0</accession>
    <name>A0A6P8IXM0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116306264</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031572151.1">
        <property type="nucleotide sequence ID" value="XM_031716291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXM0"/>
    <dbReference type="FunCoup" id="A0A6P8IXM0">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="GeneID" id="116306264"/>
    <dbReference type="KEGG" id="aten:116306264"/>
    <dbReference type="InParanoid" id="A0A6P8IXM0"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001026">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01223">
        <property type="entry name" value="Pmev_kin_anim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13101:SF1">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036639">
        <property type="entry name" value="PMK_anim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="14"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031572151.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23912" checksum="D65AEA120BE484BA" modified="2020-12-02" version="1">MAAEPKVVCIFSGKRKSGKDFVVGKLANLIGVEFCEVLRLSGPLKQEYARIHALDFNKLLDSSSYKEKFRKDMIQWGEEKRNQDPSYFCNLAAKMAYHENTISTESSQQLITKLVWLVSDARRVSDVQYFRSHYPNVLHVRVQASEQVRKSRGWVFTAGVDDAESECGLDNEVYEVVIKNDDDDDDQEREISFLVISLYDNLINDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXQ0</accession>
    <name>A0A6P8IXQ0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 G2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin carrier protein G2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase G2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116305994</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AUP1 (via C-terminus); the interaction recruits UBE2G2 to lipid droplets. Interacts with ubiquitin ligases AMFR/gp78 and RNF139/TRC8; recruitment to lipid droplets by AUP1 facilitates interaction of UBE2G2 with AMFR and RNF139, leading to sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031571877.1">
        <property type="nucleotide sequence ID" value="XM_031716017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXQ0"/>
    <dbReference type="FunCoup" id="A0A6P8IXQ0">
        <property type="interactions" value="2092"/>
    </dbReference>
    <dbReference type="GeneID" id="116305994"/>
    <dbReference type="KEGG" id="aten:116305994"/>
    <dbReference type="InParanoid" id="A0A6P8IXQ0"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031571877.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18303" checksum="6AAB20777A5518E8" modified="2020-12-02" version="1">MAGAALKRLMAEYKQLTLNPPEGIIAGPMAEDNFFEWEALISGPEGTSFEGGVFTTRLTFPHDYPLSPPKMRFVGEMFHPNVYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRENRTKFNEIAQQIVRKSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXQ6</accession>
    <name>A0A6P8IXQ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch-like protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571959.1">
        <property type="nucleotide sequence ID" value="XM_031716099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXQ6"/>
    <dbReference type="GeneID" id="116306067"/>
    <dbReference type="KEGG" id="aten:116306067"/>
    <dbReference type="InParanoid" id="A0A6P8IXQ6"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF501">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571959.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="69594" checksum="94D7454D4D80C125" modified="2020-12-02" version="1">MASGPAEHYYPRGTTFSEENHDRFIFKRLGQMRYHSVLTDVILNVEGRQFPAHKNVLAASSDYFMAMFSGHMAIASNTVDVHEISAGAMELLLDYVYTGFLEINEDNVEDIFCGSCLLLLDSVTQACCRFIQERLTLDNCWGIRTLADKFDCRDMLNNVNKFIEESFTKIVEADEYLLLPRQEIAKLLDDDAIVVPNEEVVFEALMKWMNHDLENRKADFPYLLQKVRLPQVKPEYFETFIARNELVKEIPEANEIIADAREKFYSFEDTQEIVCNSDSTFNEAAKKQRVNWESPRRCLRFLEVVVTVGGGALCEFFDADYNAWVPITPPLTRHCPGLETLDNHIYIVGGSKEWKRSDRCERYDPELNEWVVLSPMKITRSNIGLVNLNGYLYAIGGYDGRSPVRVVECYNPKKDEWTYVKEMNNCRDGACVVSDGMYIYAISGYDGNNYLSSVEVYDPISDKWTVGEVDPIVERREDAMAAVVDGKIYVIGGEHHNTFLASVEELDLDTMKWDFKTPMSGSRYQAGVAVLNKTIYICGGWTGEGLASSSVVCYDITTDSWSEVASLPAPSAARTTSCRFPRTQIERLRKSKNRKSGNGSDANNANNDLGIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IY38</accession>
    <name>A0A6P8IY38_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Uncharacterized protein LOC116306129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4 5 6 7" type="primary">LOC116306129</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572037.1">
        <property type="nucleotide sequence ID" value="XM_031716177.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572045.1">
        <property type="nucleotide sequence ID" value="XM_031716185.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572052.1">
        <property type="nucleotide sequence ID" value="XM_031716192.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572059.1">
        <property type="nucleotide sequence ID" value="XM_031716199.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572067.1">
        <property type="nucleotide sequence ID" value="XM_031716207.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572075.1">
        <property type="nucleotide sequence ID" value="XM_031716215.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306129"/>
    <dbReference type="KEGG" id="aten:116306129"/>
    <dbReference type="OrthoDB" id="5960670at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031572037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572075.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20492" checksum="D53963681F1D1CAB" modified="2020-12-02" version="1">MGCSPSHALIINSSRTHHEPVCPLQPRIYMVSESTLRILQDVGELRLYQQEDKDPGVARVRFGTTTLDQLENPVGYQSKIRKQVSVDSEQEVKVLQNDSEIAPVNLETVQGNNQGAMEEDSVDFNEQDVNETTGLLTGDDTSQCSISSSSTLIAAQIHNPLXLKSIAKVSVPSDEKSRTETPDSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYW6</accession>
    <name>A0A6P8IYW6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116306437</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572364.1">
        <property type="nucleotide sequence ID" value="XM_031716504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYW6"/>
    <dbReference type="GeneID" id="116306437"/>
    <dbReference type="KEGG" id="aten:116306437"/>
    <dbReference type="InParanoid" id="A0A6P8IYW6"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36535:SF1">
        <property type="entry name" value="DUF1772 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36535">
        <property type="entry name" value="YALI0E30327P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572364.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18412" checksum="049EED3C96E8AADE" modified="2020-12-02" version="1">MKFDCDTMFPVFKAVSTISVGLFAGGGIYINIVEHNARMALDTKSCHAQWKASFDRAKIHQRRLALITAISGAGAFYCKPSEGMTFLIGGCSMLLIFPYTLFILKPASIDPIYDDYDKIVDRESEEFVRDTIVKWNNYHSVRSVLSLGVLVGFVSQILHETPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYX3</accession>
    <name>A0A6P8IYX3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Progestin and adipoQ receptor family member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116306450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572377.1">
        <property type="nucleotide sequence ID" value="XM_031716517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYX3"/>
    <dbReference type="FunCoup" id="A0A6P8IYX3">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="GeneID" id="116306450"/>
    <dbReference type="KEGG" id="aten:116306450"/>
    <dbReference type="InParanoid" id="A0A6P8IYX3"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031572377.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36330" checksum="71ECBE81336F465D" modified="2020-12-02" version="1">MASSSVIIEIEDPQPIPDKAIKLYEYHEIPYFLRGNAYITDGYRAYLNSKWCIKSLFMMSNESINIWSHILGFWYFSFLLIYDNFLKIPYVAGSTLADYLVFSALLIGFQLCMLFSAGYHVFCCHSERVFHRWFALDLAGISLGLCTCYIPSVYYAFYCHVTLRTLYLTGVCILTILTISFQAHPHFLTSHWARRRLLLFCSMVAYGVMPSTHWVYLNGGWDQEIVKLFIPRVVVQYILGILALSFYAFKIPERYFPGKLNYIGSSHQWWHLLVVIAFCWWHQSCIFYMEYLKEHECEATTVYTDNMPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0W0</accession>
    <name>A0A6P8J0W0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573114.1">
        <property type="nucleotide sequence ID" value="XM_031717254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0W0"/>
    <dbReference type="GeneID" id="116307106"/>
    <dbReference type="KEGG" id="aten:116307106"/>
    <dbReference type="InParanoid" id="A0A6P8J0W0"/>
    <dbReference type="OrthoDB" id="5990207at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573114.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12237" checksum="6181C9CCAC18474B" modified="2020-12-02" version="1">MVFIGKWESPRRHRTSECCFFALEPTGAVPSTSNMTPIVTTTSTSSSTSLQSARTQVDSAMEPNETKIKARGMILQQLVELKNLKDANVLSNDEFEEQKKKMLEDLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1D6</accession>
    <name>A0A6P8J1D6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mortality factor 4-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571610.1">
        <property type="nucleotide sequence ID" value="XM_031715750.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="116305775"/>
    <dbReference type="KEGG" id="aten:116305775"/>
    <dbReference type="InParanoid" id="A0A6P8J1D6"/>
    <dbReference type="OrthoDB" id="10044771at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WGS project CABT00000000 data, contig 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571610.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51060" checksum="57451787AB21785D" modified="2020-12-02" version="1">MASSVRSNPAPKFVQGETVLCYEPDLTKSRVLYEAKVLEVDLTKDEKGKKVPEYFIHFNGWNKSWDRWVIEDQVLKNSEANKALKAKLHEQACKSKKKRKQQRASTSSEDNIQSTSNNFNAEISSYEAENTDQPKVEIEIPSQLKLRLEDDCYFIKRKKKLIQLPRTPCVEDILEEYYQYYLKTNSESSAHLVKELMDGLKIYFNFTLPTLLLYNFEREQFRQIMQLGPGESASNDSQPSSEQNGSALEEKCGVVSSTTENAKTVDEPTNSPREKEKRILRRRALRSNAAHSDQQTSPASQSGSDNKNQNDTLDQTNPSNVTNNEESQSSMVSSTSSPLHVDNSVSRLSTKRKAKEVEETEPSNKQPSSGLSSSLPLTVALLSASCKVLPSKLYGPEHLLRLFVKFPGLLVKTNMPEVNLSALLDHIDLFLKYLVERSPVLFQDDVYQSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3R6</accession>
    <name>A0A6P8J3R6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116306334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031572230.1">
        <property type="nucleotide sequence ID" value="XM_031716370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3R6"/>
    <dbReference type="FunCoup" id="A0A6P8J3R6">
        <property type="interactions" value="1219"/>
    </dbReference>
    <dbReference type="GeneID" id="116306334"/>
    <dbReference type="KEGG" id="aten:116306334"/>
    <dbReference type="InParanoid" id="A0A6P8J3R6"/>
    <dbReference type="OrthoDB" id="5968052at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="7">
        <location>
            <begin position="521"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031572230.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119955" checksum="F738B0ACB2FAE5F1" modified="2020-12-02" version="1">MVDAHVARKHWRCTLERAEKFISNQFFSDINLYSRLYPKSLPVTSITHYAAPGRITYEEAVKGEYSPAKVGESFGPTWSTHWFKVIIDIPEEWTGERVHFRWNSESEAMVWQNGKPIQGLTGADGHQQRTDFLLSYKATGNESYTLYIEMAANEMFGAGKDGLINAPDPSRTYSLSMAEIAVFDTDCYDLLTDLTVIIDLAKHLPEGSSRSFEALYTANKIVNACDTSNRSTFGKVHKEIAASFFAQKNGESQHKVYAIGNCHIDCAWLWPVAETIRKCGRSFATAVRLMEKYPDFKFACSQMQQLEWVKIHYPSLFEELKHFASKGQFIPVGGTWVEMDGNIPSGEAFIRHFLIGQKFAKEEFGKECEVFWLPDTFGYSAQLPQIIRGTGIKYFLTQKLSWSLINKFPFNTFFWQGIDGSKCLTHFPPADTYESRADAGDVLKTAHKLKDKGKVHGSILLYGHGDGGGGPSEEMLDMLKRMEDVDGCPRVSLSTPEDFFTAVDKQDSNKLCTWVGELYLELHQGTFTTQAKIKAENRRGEFLLHDAEFMCTLAWALGGHRPDLYPTEKFLQIWKPFLLNQFHDILPGSCIPEAVTDALQAYEEVHAAATKIFDTASNNVISKLAPNTTDCTLKPVIFNTLCFDRQEVIPVPQELIKNLSKEEQISIETQKTNDGQTLAMVSVPCMGINTVNCTPKTEFQPVVVQEDQESGHVTIQNEHFNVIFDSCGRVVSFIHKQSERQAVSSGCHANQFVLFDDIPLYWDAWDVMPYYLEKRISLSECTKPNGTLKVVEKGPLRATLEFSLAISSSSSLKQVIIVDSCLPYIKFDTKVDWHENRKFLKVEFPVDVHSMNATYEIQFGHLQRPTHCNTSWDWAQYEVCGQRWADLSEHGWGVSLMTDSKYGYSTYGNTMFISLLRSPKAPDDQADMGNHEFSYALFPHSGTFQDAGLIRHAYCFNESLHVRGCVVGSGFKTESFFRVDNPAVVLETVKKAEKNPSAFILRLYESFGGKAKTRLTTSLPLKHVQRCNLLEVPEDDAKITWYDGGIQLTVGPFQIITLICSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3V9</accession>
    <name>A0A6P8J3V9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">von Willebrand factor D and EGF domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116306370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572275.1">
        <property type="nucleotide sequence ID" value="XM_031716415.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J3V9">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="GeneID" id="116306370"/>
    <dbReference type="KEGG" id="aten:116306370"/>
    <dbReference type="InParanoid" id="A0A6P8J3V9"/>
    <dbReference type="OrthoDB" id="5982528at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26129">
        <property type="entry name" value="Vwde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="428"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031572275.1"/>
        </source>
    </evidence>
    <sequence length="1069" mass="121055" checksum="414CCC179EEA74FB" modified="2020-12-02" version="1">MQFRSVKEPKLLNSLFHFFLVFVVSSFFIGTRGTQXNDVDPCKAYQEINDPYRSTKSRLKAGMRANCDYDLSKGWYRFTSIVGGQIPTTKPEPFYCNTIAPIWMKGELPKTKGEQIHATACVNFFNLAGGCKRKFSMSVKYCDGGDGQDGEDFYIYRLSPVRGCAMAYCAGNQTPCPRGMTGIEPNCNVSKIVKFPYTRVPRPKVDYVKDINTLAMSCKFHFPPWNNVSYAVEWFADGRLIRTQWMCVGVNSTCDRKNLESIVNYGSFKMGQNLQCRISMKYSTSPDNKWSAAKYSNNFYVGIEITPRVTHIVVKECDRNSDVTINLRPTVPIYNNTYTPKVDYLSLSILVPKKDKNQNKAAIDTCNVTLKTEDISSGKDITIKGICNNLNDGVSQSRFYFVPETTYLPWRDYRPPALLVWINTTEIKTCSGTGDPHYKTFDGKVFHFYKPGNYLMYSNANKTVEVQTRLWTCGESQVSCHCGVAIREKNEIVVLSVCNDVLVHKSTEFTPMTLRRNKNGFHIVKKSKGSSMVYDVFLPSGTRVKVSRIDWGIDVFITAPDTDRGNVLGLCGNFDGDPNNDLKGSDGKLYEDSRIPGHQLFGSTWEIFGKTYFETYPNKFPAQIDDDGMFCTCFPKEAKEKSSDCNTVGSYYFDSEDNKQQTDDPEQKKKKKKRFAHTDWYSDDIIDHEPRSYFVDDPQVQHAMNRIRNKRSLKIVMSNKEATDYCRSHIEDTNAGRSCKDVSGASIGIAMEQCIADLELTGEQAYAYSAFDFMAYECKDAIFKNVSLYTKSPDGDLVPPTELVKDLCPSDCSGRGKCKNRTCICDEGYTALDCSMEVGAVPEVLGIYNGGLCDLRERPCRKTNIKGQYFISSENLTCHVQEIEVFPGPWSPRGQPXKLPGDMFDLYGVKCDLPDPPTRLGDYDHEGTPAGGLMISVSNDGFNASVQKLRHVSFDSKCMNCSNSSICERKPNSCLIRGHCFAANEPNPRDWCQQCIPRDDQNSWTRRKINQAPKFTTKKIMFAVKEEDLVIQLKATDPDNRPVTLSTQFYSYWPHIQYSWSTEMEGYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3W7</accession>
    <name>A0A6P8J3W7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C3/C5 convertase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116308431</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574706.1">
        <property type="nucleotide sequence ID" value="XM_031718846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3W7"/>
    <dbReference type="FunCoup" id="A0A6P8J3W7">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="GeneID" id="116308431"/>
    <dbReference type="KEGG" id="aten:116308431"/>
    <dbReference type="InParanoid" id="A0A6P8J3W7"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006956">
        <property type="term" value="P:complement activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011360">
        <property type="entry name" value="Compl_C2_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001154">
        <property type="entry name" value="Compl_C2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8 19" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 19" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027536703" description="C3/C5 convertase" evidence="20">
        <location>
            <begin position="24"/>
            <end position="852"/>
        </location>
    </feature>
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            <begin position="96"/>
            <end position="152"/>
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    <feature type="domain" description="Sushi" evidence="23">
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            <begin position="153"/>
            <end position="214"/>
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            <begin position="215"/>
            <end position="272"/>
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        <location>
            <begin position="275"/>
            <end position="332"/>
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        <location>
            <begin position="388"/>
            <end position="565"/>
        </location>
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            <begin position="586"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="17">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="17">
        <location>
            <position position="692"/>
        </location>
    </feature>
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        <location>
            <position position="797"/>
        </location>
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        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
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            <end position="270"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001936"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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    <sequence length="852" mass="95077" checksum="0813F0D22B7132C5" modified="2020-12-02" version="1">MLPLRELAVTLFVWILFVNVVTSAPGGNHTCEEVLRNLKKNPPPHTIIRLQEPLRKTWSVKYKCVKEAKMVHGSDTAVRRCENGTMIGDEPQCKLISCGKPVPIPHANFNGPSFTYNSIVRYRCQEGYRMKGRNFRRCKINGKWTKKPKCMIQRCTSAKNLRIRNGTITTTDPNYRHGATLVFQCNDDYELSGQDTITCIGSKWSSYSLPYCKPIRCPYPGIPVNGRRIGSRFTVGATVRFHCQSGFKLLGSSTRVCLKNRMWSGNLAVCDDGHSHCPKLGTPISGTKKGNRYDIGSFVKFSCKEGYVLVGSSVRQCQKDGTWNGTEAKCMNDFEYMVRDSNSTAKILRQNIDKMLEYTCSGVNSTCNLTAVDMRARAINPNHAGGLDLIFVFDASSSIRKPDFQLGLRFAQELVKLLGSTWKPGGTHVAALTYGTNARIEFNLGDASVNSAKKAMERIGEIKRAGGGTASRPALDLVRNAIVPFTRKGSQKVLFFITDGHSNIGGSPRKAAKFLRDEKEFEIYAIGVGKKVMRRELMEIASEPEDEHVISVRKYKELLHAVKQVVDIKIDYSPCGFSPVNLRARIVGGNKAGRGNWPWQVGIHKLDNTNKLVLRCGGALIKPGWVLTAAHCFISLDPVTFKRYKDVVPAQIYTVRAGDHHLTFKEPTQQDVTAKDIFIHQNYRDVPFIENDIALIQLREDIKLGPSVRTVCLPRKNESLLEPGHFGIVAGWGATQVLELRENPKKKKASSKVLRHSAFTIQTNELCDNKTKFYFNSEVTFCAGDGKGGNDTCKGDSGGSFVREALRDGVYRWVATGVVSWGEGCGLVGKYGYYTRVERFVDWIEKTIKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J443</accession>
    <name>A0A6P8J443_ACTTE</name>
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        <submittedName>
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        <name evidence="6 7" type="primary">LOC116306415</name>
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        <name type="scientific">Actinia tenebrosa</name>
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            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="6 7">Tentacle</tissue>
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        <property type="entry name" value="RASTRNSFRMNG"/>
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    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="228"/>
            <end position="241"/>
        </location>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572325.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28756" checksum="7D314960840CB9C4" modified="2020-12-02" version="1">MADVTCFSFDDYHKISGKASSYNTMSLSKTKEFDLQYKVIVIGETAVGKSSLIRRYANPEQPFTSNMISTVGIDFVNVDTKVDDLTVRLQIWDTAGQERFRTMTKSQFRGTKGVLLVYDITKDFSYDQLQFWIKSIKESKLDHEEFLIVGNKYDLNDEREVPKTRGEELAKSLGVKYMETSAKTGRNVKEVFHSLATQMKDANDPFVHVRREDFNMSFTDRPDGIIVPRKEERTSDSESKKKGYSSYCCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6M5</accession>
    <name>A0A6P8J6M5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin-like protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116309061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575457.1">
        <property type="nucleotide sequence ID" value="XM_031719597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6M5"/>
    <dbReference type="GeneID" id="116309061"/>
    <dbReference type="KEGG" id="aten:116309061"/>
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    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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        <property type="entry name" value="CALMODULIN LIKE 3"/>
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    </dbReference>
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        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
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    <feature type="domain" description="EF-hand" evidence="3">
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            <begin position="222"/>
            <end position="257"/>
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    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="342"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575457.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50006" checksum="6539674A3625B09A" modified="2020-12-02" version="1">MSELLSEDQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLSMMAKKMRETDTEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVEEMITEADIDGDGQVNYDGITSDLTEEQIAEFKEAFSLFDKDGDGTITTQELGTVMRSLGQNPTLSELKDMINEVDIDGNGLIDFPEFLTMMARKIRETDSEEEIREAFRVFDKDGNGFISAAELRHVMTSLGEKLTDEEVEEMIKEADTNGDGQVDYDGRLGSSLALGPLSVRFPMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVKMMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J928</accession>
    <name>A0A6P8J928_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Tropomyosin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116307355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573410.1">
        <property type="nucleotide sequence ID" value="XM_031717550.1"/>
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        <property type="nucleotide sequence ID" value="XM_031717551.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A6P8J928"/>
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        <property type="component" value="Unplaced"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
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        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
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    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031573411.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28683" checksum="219CD765A16DE8E5" modified="2020-12-02" version="1">MEGLKRKVVQTRQEIEKAEIKEKYFRKLLRRQGERAIIAEMEADGLRNRIKDIEARIEKLNDKTYQVSLGVQAKSLENDDSEKDRKTMEGKEYDHSDQIALLEDRVADVVRDVDEKEIRLEEAKRRLTETKANLASANDRAEEADKKISILENEIHSMCKDLYTLERKAERRFKRNDYFADKVEELDLRRRNAILRADDSQIEGKQLQNQCDKVSNSLSREKKRVAFMKRELEDALADLNIARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAB6</accession>
    <name>A0A6P8JAB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease P protein subunit p40-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116307637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573770.1">
        <property type="nucleotide sequence ID" value="XM_031717910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JAB6"/>
    <dbReference type="FunCoup" id="A0A6P8JAB6">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="GeneID" id="116307637"/>
    <dbReference type="KEGG" id="aten:116307637"/>
    <dbReference type="InParanoid" id="A0A6P8JAB6"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031573770.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42650" checksum="6620F3E4CB802BED" modified="2020-12-02" version="1">MADVKQFKTPKRRLVFEKNSLEDTKQRHKKQITEHYFNHSVSLVIPGCAIGTVKHYFREHLPSLDEFCVAVLPLHVFIEKEFIEKFIRQGNFYALSRKTKLDTENCVAVLPTGILLLSLDKDTYEELGLVGKQSIFQNKLRFIVEIDLKSPSFHPGKNLYERVRWCLKEHLDLEFEFVFTWTDTDNKLDIKDIQSHFRLYKCCPFKNKEDIRSLSNARIPVVNSQETQLTDKDNDNISCAGASGFYEWLGSIHCDIECSSGSPDSYVSTFTCPNPSTVSKEMVKCQWTGFITPQRILNLLEASRSFLQCSPEKPPWIALNVWGFADTPVSWLKNEHGFHYEGDNMYTMIIFPSDIYWCYMALGSNDVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAL8</accession>
    <name>A0A6P8JAL8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Melatonin receptor type 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18" type="primary">LOC116308486</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16 17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574772.1">
        <property type="nucleotide sequence ID" value="XM_031718912.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574773.1">
        <property type="nucleotide sequence ID" value="XM_031718913.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574774.1">
        <property type="nucleotide sequence ID" value="XM_031718914.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574775.1">
        <property type="nucleotide sequence ID" value="XM_031718915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JAL8"/>
    <dbReference type="GeneID" id="116308486"/>
    <dbReference type="KEGG" id="aten:116308486"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="30"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031574772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031574773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031574774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031574775.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38823" checksum="86B229937B70B55A" modified="2020-12-02" version="1">MSYQVHPRSTTWVVLESIALVTLNIIIFFGNFIICLVIYKSKRLRTMTNMLVVTLSISDLITASITLPMAAATSILRRWIYGSIGCQVFGFCSKYLVHVSLYIITLIALNRYVRIIKPSLYKKVFTLRRSVALLAFIWVMPALVRIIPILTSSARFVFVSHTATCILAFYEKKSQFPYTVFATLVFIALPMLVIIVCYAAVTRHVRKHRQRISSVRGDQGDLGVSIEEVKVTRTLFALVFTFILCWLPVSVALIFVKSATGSIPTLAARVLSCLVALSSASTPFVYGVLNRPFRKEFKKILPLCCRGNRTFDSESAWNLGLNARDSARNRQGPGNQSSNSAENKCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JC75</accession>
    <name>A0A6P8JC75_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Arylsulfatase J-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14" type="primary">LOC116308868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575233.1">
        <property type="nucleotide sequence ID" value="XM_031719373.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575234.1">
        <property type="nucleotide sequence ID" value="XM_031719374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575235.1">
        <property type="nucleotide sequence ID" value="XM_031719375.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575236.1">
        <property type="nucleotide sequence ID" value="XM_031719376.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575237.1">
        <property type="nucleotide sequence ID" value="XM_031719377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308868"/>
    <dbReference type="KEGG" id="aten:116308868"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653313" evidence="7">
        <location>
            <begin position="29"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031575233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031575234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031575235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031575236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031575237.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="62194" checksum="781CE0FE783C0509" modified="2020-12-02" version="1">MNRRITYDVIWRLVLFTAQAFCAVSVQGAQNPPHIVMVMVDDLGWSDVGYNNISAVNTPNIDRLAADGVKLMSYYTQAMCTPSRGALMTGKYPLHTGMQHFVINSTSPWGMPRNLPTLPEKLRKLGYSTNLVGKWHLGYFDWDYVPTARGYDSFFGIYMGEGDHWNHSKMGYLDMRRGMEPTWDYRGRHSTDVFTDEAINIVTRHDQTKPLFLLLSYTAPHTPLQAHPRDIDKYKHISDVKRRNYLAMVDALDQAIERLVDTFKNKSIWNDTVFIWFSDNGGFPGPGGGYNWPLRGLKSNIWEGGIRVPAFVHGSMLKRRGVKINDLFHVTDWYPTLINLAGGTVDEDVDGVDQWKVISEGQSSKRTEILHNIDYAPDLKAMNYAPLGFSYYTGAAIRIGHMKLLHRSPNSTWYGLPENGAAPPKMLTIDRLPFIDIALYNITXDPEERHDLKAKYPEVVQQMLARLKEYNSTVMKYHLQPEDPECLKLAKRLGRWEPWKDEDCITSSGTIHYPVIDYCGPXPIVGIKTICAIWIAFLWTLLGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCS4</accession>
    <name>A0A6P8JCS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116309015</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116309015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575398.1">
        <property type="nucleotide sequence ID" value="XM_031719538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCS4"/>
    <dbReference type="GeneID" id="116309015"/>
    <dbReference type="KEGG" id="aten:116309015"/>
    <dbReference type="InParanoid" id="A0A6P8JCS4"/>
    <dbReference type="OrthoDB" id="5976521at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031575398.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60540" checksum="BD89D59BA8278C57" modified="2020-12-02" version="1">MSKFDQIRLFMLDSDNRPQIDILSINESALKTSIPDSLYAIPGFSMHRRDRKGIKKKGEVLVYINEVKHRRRTDLEDSNIEAVWLEGYPFKSKRPILFAGVYRPPSNSKEKDELLEKNIESAYLLNLETIAIGDINVNYLASSTFKKHCLVRALTSMNFKRLVTQVTRPISKTCLDHVFTNRPERIHSVCVRNSGLADHLPVFAVFKMERFNETQFLATLQEIPWDTSFIFDSVDDILCAWEDLFNKALDNHCPWRGKRVAREKQAPWMTNEVLRHLQKRDSLLKTARVSASLDAWENYKSARNKATNLIKTAKFKFYDNCFENSKGDSKGIWKTIKSLTGTSNKSTKSDGMTADEFNFHFSSIADRLRSLLPRIPFGISKLEHFVLSRKDPDVKFSIPPLTKGFVVDCLRNLNSNKATGVDKFSARVLKIAALVIVSSVTKLMNYSLGSSVFPKRWKTAKVTQSFKAGDRGDPSNYCPISVLPILSKIVERHVHNHLYDYLNDNNLLYARQSDFRRQHGTERLLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GXA0</accession>
    <name>A0A6P8GXA0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116286501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031548889.1">
        <property type="nucleotide sequence ID" value="XM_031693029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GXA0"/>
    <dbReference type="GeneID" id="116286501"/>
    <dbReference type="KEGG" id="aten:116286501"/>
    <dbReference type="InParanoid" id="A0A6P8GXA0"/>
    <dbReference type="OrthoDB" id="5949690at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="125"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031548889.1"/>
        </source>
    </evidence>
    <sequence length="720" mass="80242" checksum="C296930B49F31BA5" modified="2020-12-02" version="1">MSLLCAKSGDIGVTRSKSNTTTTSGFQVSFQRSRQRFCAFSVSIVIVPLMNRTREKKMKNRAVQDDKLRQQSVEIEGSGGARRCNLVTNDVTHLYDDVSTVYEAFLNGIKVSGDGPCLGSRKGSGPYQWMSYSQIHERAANLGCGLLELGCQSSQETYIGVWSKNCVEWFLTDMGCQMFSMVTVPIYDTHGPDACIYIIQQASLKVIVCNTDKVSFLLEKANECDSLKTIILIGGPVDGSTLAEADELGIKIHIFEEIEELGKNNKHPILPPGPNDVHTISWTSGTTGYPKGALVTHGNIISNMAAYLFIIKQDGVELNAHDVHLSYLPPEHMYERCTQVLMLSSGARIGFSRGKRETLMEDFQELKPTVFSAVPRLLNVIYDKVTAQVLRSKLKKWIFDIAMHSKQQDLKRNILRKNTIWDRLVFKKIQNLLGGNVRIITCGSAPLSANVTTFIRCVMGCYLQEGYGQTETTAIVTMQRLSDFSTGHVGAPAPCNQVKLVDVPEMGYYAKDGHGEICVKGQNVFKGYLGNPEKNAECFDDGGWFHSGDIGQWNENGTLKIIDRKKHIFKLSQGEYIAPEKIQNAYLRSPYVAQVFVHGYSLKSCIVGVVVPDQEMLFALAKSKGIQGDLKQLCQNQTIRKLIHDDMLTRGKDAKLNSLEQVKAIYLSPNSFTIEEGLVTPTMKVKRQAMAAYFDVKIQQLYDELEAGQIKKNLGERKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GXG4</accession>
    <name>A0A6P8GXG4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116286545</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116286545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548964.1">
        <property type="nucleotide sequence ID" value="XM_031693104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GXG4"/>
    <dbReference type="GeneID" id="116286545"/>
    <dbReference type="KEGG" id="aten:116286545"/>
    <dbReference type="InParanoid" id="A0A6P8GXG4"/>
    <dbReference type="OrthoDB" id="6021814at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031548964.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22141" checksum="C0E6AF33CC635012" modified="2020-12-02" version="1">MLNVDWFQPYKHTNYSCGVIYLVVMNLPREERFKTENVILVGIITGPNEPKGNINSFLQPLVSELTDLWDGVILNDRCIPGWAVKIKVALLAICCDVPAARKCDGFAGHSALKGIQLMRKFLRNNDLQQSDWPEEFVGFGDCLIHLMFFLLDKHPLSLKTICRIEKKKLYAFHQSRELALTVILQPNFLMYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0T2</accession>
    <name>A0A6P8H0T2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC116286546</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116286546</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548965.1">
        <property type="nucleotide sequence ID" value="XM_031693105.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031548966.1">
        <property type="nucleotide sequence ID" value="XM_031693106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286546"/>
    <dbReference type="KEGG" id="aten:116286546"/>
    <dbReference type="OrthoDB" id="5963004at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905762">
        <property type="term" value="F:CCR4-NOT complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07307">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031813">
        <property type="entry name" value="DUF4745"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043385">
        <property type="entry name" value="GARRE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15703:SF3">
        <property type="entry name" value="GRANULE ASSOCIATED RAC AND RHOG EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15703">
        <property type="entry name" value="RIKEN CDNA 4931406P16 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15923">
        <property type="entry name" value="DUF4745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4745" evidence="2">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031548965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031548966.1"/>
        </source>
    </evidence>
    <sequence length="1254" mass="138239" checksum="539F2A2D68045D0D" modified="2020-12-02" version="1">MDSVRYLSYHQWRTRKEGDEKPSRYHQKLLANVESLQNNVSSIDKLISEYLDATKTYCGAGSHLAEAFSSVLKDTPLLEITQQLKQVVEEVDHVAHKSSVHIINHILGTLCEFTATFPDLKRAIEAHKRCAQNYEACQENLESLDKDESLSEGSKRFKIAKKRFRSADEELSTEEENLYRSFTEVEENRIKMLGSCFLSLLQVQSQFLTASSELMSPLGCFQEIGDYLRDREVTLALKDATSAWLSLAQANQSLRQXKGLTREDVQLLMHSFDEELPEPERKQLAGRVDLLLKNYQKEFERAPTPEADIPGGFHKHPKGAELALKGCCSETEALAAGGQQGIVSDEQMEAEILKQIPKLLLKIGTVTHETCPSPSKAPDNLKSKLHCIRELVNTVATHNDIPLNKENLDNFVLSVLYEPCSPICVSSAKTAVQLLFGRANLVTIKPCKDSNARLAQVAVKSTSVHVEVLSTWSILANQALFSCISRDLDLNTPLGIVEATYVVKFSLMDFLEDKERPLPTIYMKRYNSPHSPQTQPKQESSPSHRQNRFRKSLTKATSKIFSRKSAQGAKASGNSANPPGSPSSNSVPSTGTXSPGNEGFRMSFITSSTDTSNEQDTDIEEPAPLPPPRPKHWARKVQAQNMGPGALIKPDGELTQSHKKSDDWYQTDPKFPLPKFKPTLSDSQSQLSVASQQELDEVIKFLSGTPLKSRPPPSVDNVSHVTPADSGLGSSLSIACSSITLASITGGLEGAGREAASVKAPRVEVSEPEASQNTDSTETPKETKKDSKPRKGKNKQDSETKKENNKTSSESTKGKKSSKKSIKSQDSGKSGVDGKETKNDHKKKTMAEEPKAKDGGRKTEEVTKEKAGGQKKVGETDEKVGGLKTECGTDEKVGGKKTEGGTKENDGGLKDEKKDGTSPVVVTVSSVDDDKEKGDQSKVTISESLRSVWENADPAKKRDSGGVTALQLSRLKEKYGSQETLYHSCWSLSEFDGNDKDNQDEDTRSLNENMLPSNASPVMDLGLMWSPGFANDVWSSNPNIKDSDEAENTHWCRSDETLDRSTHGGKNVFSLGLGITGPELFAAASQAGRDDYVKEKCLTIPEMSKPRXAEDLSCKDPWPSRSTSPTPHPHWTKTASLNDDSHRQSVHRQTLPPQHYSDPFLPNDHWWSQVGPGLPHPSNPRYQQYLQRQYAVDVNYQGVQSNPHGGYSSMGMSAFHPVQQRFSKPSRPAHLQVPPHYPNGNGSGNNHHASNPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3E3</accession>
    <name>A0A6P8H3E3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chitinase</fullName>
            <ecNumber evidence="1">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116287430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031549971.1">
        <property type="nucleotide sequence ID" value="XM_031694111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3E3"/>
    <dbReference type="GeneID" id="116287430"/>
    <dbReference type="KEGG" id="aten:116287430"/>
    <dbReference type="InParanoid" id="A0A6P8H3E3"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028281152" description="chitinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="33"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="388"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031549971.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49380" checksum="CC6C7E213AA2F44E" modified="2020-12-02" version="1">MDLRIVLLTVISFCVVELVASYRINERALPNRQLLVGYWGQNSAGPKFGKWKYERDLRHFCNNFKFDIYVIAFVHRLFDPRHADRLPGMNFAHHCSYVPDPKYPGIYECASIGGAIRDCQKLGKKFLISLGGDTCDGTLGSAANARFLAKNIWNMFLGGQELPGKRPFLSAVLDGVDLDIEIGSYKYYPDFVKELRRLMRTDPSRKYLVTAAPQCPYPDAWMGPVNPGTAFKEVGHEFDYLFIQFYNNYCYPGSQYYVSVMDQWLKWTNSINNGPLILLGLPSGVGGAGKPEYYFPPDQLAVAYKKIRDKPGVGGMMFWECSWDQNNIINGRHYSEYAFELVSGGSITPPTQAPSTNPPPVTTTKPPVVTTQAPVTTAKPTTSTPTGSVDCSSSPDGYYPEPADCSKYVVCASGVAYHKSCPPGLNYNKVKKYCDWPHNVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3I9</accession>
    <name>A0A6P8H3I9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ankyrin repeat domain-containing protein 50-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550016.1">
        <property type="nucleotide sequence ID" value="XM_031694156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3I9"/>
    <dbReference type="GeneID" id="116287479"/>
    <dbReference type="KEGG" id="aten:116287479"/>
    <dbReference type="InParanoid" id="A0A6P8H3I9"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF55">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like AAA+ ATPase lid" evidence="8">
        <location>
            <begin position="220"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="9">
        <location>
            <begin position="305"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="675"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="713"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="793"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="826"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="859"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="892"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="925"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="958"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1187"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1213"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1227"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550016.1"/>
        </source>
    </evidence>
    <sequence length="1267" mass="139250" checksum="1F8C640438F86EB8" modified="2020-12-02" version="1">MNTRVRGCRSFYCRDWVFEKVLTCLQRRKEQEDLKTKGAFIVGGPGSGKTTLLKELIFPSIKDGPQHDLSKKVLAHHFCEAHNYSTVSVSEFIKSLAEQLAKAEPLNSYREKFNESQIQDYLKPEQCAKNPDVSFKEGILLPLNSITPPEDVFVVVVDSIDESFLHSFDSGVFSGSRTIAELVATHYDLLPPWLFLVISARKQSKTVTKMFTGFRKLTLDDLRKAHVVRDIQGYILNRLDDDKELRKYLTRETAEIFNQLHIKSNGCFLYLEKVLDGIEEQLFSLDEVQDIPGTLNGLYLWLCNRLYKEEQFNQMRLILNVILASQKPLEANELYQAVWTRNSSICTKEFHNILESMSYMVVNVEDSKCIFHHSFAEWLIDVKHCTPRYLCSPSDGHAMLALRCTLLASNKQSVDLHQFAVHLSRASFKEELSQEHFALWLLWSGAPLSETLAATDQPKQKALQILLDAGADVSNVDESGELAISYGKETEESIKAFLEKGSSVDRVDSVGRTQLCNAAFNGNTDVVKILLQHGANVNYSDPSGESPLILAAKQGHADVVYLLVNCGANVNQSSSDGCTALRASASGGHSDVVSILLKHGANVDQADNDKRTALRGAAWGGHADVVQQLIEHGADPNHTDKDGRSALIAAAYMGHKSVVRYLLEHKADVNLADKDGRTALAVAVLCISANPEHTEVVKILIEYKADVDRPDYDGMTALCVACLEGHYNVVKLLLNANADISHWDRNGRTPLFAAAASGHVGIVKILLEKNSKGQPSSGDWRAPKDAMFRADNGGWTPLMVACFQGHSSVVKALLEAGIHMNDRDKENKTCLIIAAQEGHSKAVSTLLMFGAPVNQEAKEGRTALYYAAMEGHFDSVDVLLKNGADINGVDSLGRTALFSVTIEGSEEIVEHLLRHGATVDCVDNDGRTPLQGAAWQGNYNLVALLLKYNADVNFGDNFGRTALMSAAWQGQNSVIQLMIDNGADVDKVSSEGATALSIACQEGHDEVAQILLENGANMNHTDTFGRTPMQVASEAGHTKIMKALEAYSVVRMNDNSFTSALKRRVSTPAEIPETTSLVCEVITRKESISSSGSSTQGSRHDVSSQDDGEGASGSLPTPRLSHDRRYSSSFLEVHKIAAAKEPWSSKCPPYTSQETVHREPPPYTEQVLHSSVTVNDDIAPVKPNSPKTRRKPFSMLHKIKRPFALGGSGERKNKSKTPHDKRRLFSSRKSSSSGKSTEVVSDPPSSSGLDHLDYRLSDSQSSVETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6Y4</accession>
    <name>A0A6P8H6Y4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-related protein Rab-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116288458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551108.1">
        <property type="nucleotide sequence ID" value="XM_031695248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6Y4"/>
    <dbReference type="FunCoup" id="A0A6P8H6Y4">
        <property type="interactions" value="1943"/>
    </dbReference>
    <dbReference type="GeneID" id="116288458"/>
    <dbReference type="KEGG" id="aten:116288458"/>
    <dbReference type="InParanoid" id="A0A6P8H6Y4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551108.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22978" checksum="E425A1E1324FD702" modified="2020-12-02" version="1">MAKKSYDYLFKLLLIGDSGVGKTCILFRFSDDAFNTTFISTIGIDFKIKTIEMKGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITQEKTFENISKWLRNIEEHANEDVEKMILGNKCDMDDRRIVSRERGEQIAREHGIRFLETSAKTNVNIEDAFFALAQDILKKQLTKDNDEPSNNIHVQDSKDQKKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7F0</accession>
    <name>A0A6P8H7F0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ homolog subfamily B member 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551238.1">
        <property type="nucleotide sequence ID" value="XM_031695378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7F0"/>
    <dbReference type="FunCoup" id="A0A6P8H7F0">
        <property type="interactions" value="2798"/>
    </dbReference>
    <dbReference type="GeneID" id="116288575"/>
    <dbReference type="KEGG" id="aten:116288575"/>
    <dbReference type="InParanoid" id="A0A6P8H7F0"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000021">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551238.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27814" checksum="E319EF4AD2686E63" modified="2020-12-02" version="1">MADYYEILEISRSATEADIKKAYRKLALLWHPDKNPDIKEAAEEKFKEISEAYEVLSNKERRDIYDRYGRDGLTGGGGRGAGPDFDFDFHFHRPEEIFKNFFGTNDPFSTFFDDDIPGFGSSFFSRKKKNNPSNRRNEPSHHGSLFSDPFSDRFSDPFGGFGFGFSRSFGQDPFSTSSFASFSNFGNGGNGVGAANVRSTSTSTKYVNGKKITKKKIVENGKETVEEYENDTLIKRIVDGTPLQITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8A6</accession>
    <name>A0A6P8H8A6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289877 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552674.1">
        <property type="nucleotide sequence ID" value="XM_031696814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8A6"/>
    <dbReference type="GeneID" id="116289877"/>
    <dbReference type="KEGG" id="aten:116289877"/>
    <dbReference type="InParanoid" id="A0A6P8H8A6"/>
    <dbReference type="OrthoDB" id="10380138at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552674.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25863" checksum="0D39627DD515E947" modified="2020-12-02" version="1">MDTSLHSTLGIPYNSENNMPIPEEIKSQSYKFNPVTPDVSPPQPPGRMSQLSTPRNQQNFLDSRAFGDISNVTSMDIHEMENVGNHLQNMLKTSKDLIIDRDYEPNVHTGSADQKDVPRDGAENHSMSSVDTAAFFQKMLPNSSPLEELKVHLEFGDQSRGAHAKDDTSQTSHSSIRHASDVRKQVAHPQHPTSGANKSLMLENTLLREHLDGERSRRKPFHVKSSISTQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9U7</accession>
    <name>A0A6P8H9U7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116289203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551943.1">
        <property type="nucleotide sequence ID" value="XM_031696083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289203"/>
    <dbReference type="KEGG" id="aten:116289203"/>
    <dbReference type="InParanoid" id="A0A6P8H9U7"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF101">
        <property type="entry name" value="PROTEIN WNT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027792340" description="Protein Wnt" evidence="12">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551943.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41413" checksum="ABE2F9992AAFB7A7" modified="2020-12-02" version="1">MGASSVVMVWIFIAXFGAAKPGQRVERDVPFMPNANALELASNTNAEKLCPLLSWLKPHQKKKCLLYPALVANVQRGVGMALTECKNHFSDHQWNCSGINTAQVFKSRGILTTGSRESAYVYAITSAGVSYQVTKGCAAGNLDSCGCDLRVRGREPRKGKEPGWEWGGCSENVNFGDEFSRKFMDWQPATKDIKYLLMKHNNEAGRKSLRDNMGKSCKCHGVSGSCTVKICWKTMPNFSVVAQLLRIKFDRSIRVRANANKSKLQRTTRGKRGKQRKRKDKNRKPPASSLVHSESSPDFCRPNLSLGILGTQGRICNTSSTGNDGCKHMCCSRGHDTVERSKMAKCNCEFIWCCKVKCELCERDWLEHLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAY4</accession>
    <name>A0A6P8HAY4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549655.1">
        <property type="nucleotide sequence ID" value="XM_031693795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAY4"/>
    <dbReference type="FunCoup" id="A0A6P8HAY4">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="GeneID" id="116287151"/>
    <dbReference type="KEGG" id="aten:116287151"/>
    <dbReference type="InParanoid" id="A0A6P8HAY4"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549655.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20638" checksum="D963906466319279" modified="2020-12-02" version="1">MADEDKHHKTMSWKSSLFGHKDVDIFRDTPIRYLGYANEVGEAFKTHIPKSLYYGSYVVASSYCLADAISKGRKIYEEGSALPMAVRRRRTIETAVEAGVWQGLASVIIPGFTINRICVSSRFILKQVARSMPLHTQTWLTTLVGLSMIPVIIKPIDRGVDYLMEGALNMLRELGVVSENVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HD26</accession>
    <name>A0A6P8HD26_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 8 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116288025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550602.1">
        <property type="nucleotide sequence ID" value="XM_031694742.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HD26">
        <property type="interactions" value="1668"/>
    </dbReference>
    <dbReference type="GeneID" id="116288025"/>
    <dbReference type="KEGG" id="aten:116288025"/>
    <dbReference type="InParanoid" id="A0A6P8HD26"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23413">
        <property type="entry name" value="zf_RING_Vps8_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1257"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1312"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550602.1"/>
        </source>
    </evidence>
    <sequence length="1415" mass="160005" checksum="DFADDFD0666AE62D" modified="2020-12-02" version="1">MADGGGYSSTDDSVLAGLLSASNDLQSLESFDAAFTTRSRDRQSFRSSSLVSDAVDIELDLPEVESIPTLESILNEKDDDLSGVDYDPELASILHDEALSSPLNLDLVPKKQETNKHGTILRHIILKNVSSQMVSACSKVDAGLPTAMAVSSLIAVGTSHGIILIFDPKQTLKLVLGNTAMGGEYGAVTALGINEDCTRLLAGHARGQITMWDLQTGKLLRTILDAHPLGSAVLHIMFTDDPNVAICSDSGGSVFILSFKRLIIGVRSYESTCLFSGSRGEVCTMAPLHMXSGMKDHPMYEYSLLALVTLTKILVLTLKPSMEVLFSHSLRGPVDSLPLVSWQFAIIQVANKKVIDPVLAFGRGNTIYFFQAHCTEEKEVKFMFLQRIETNYKLIALHWLNPHVISTLDTLEKLHVLDVRSREELEVVDLSDVQLVYSSSYFKSLSTGGNVSKALAAASEYSCYQTINVFNGQMLVLGSKSIHVLTIRTWKDRIAVLMRLNKFQDALELALSFYKGTAKAIVGLIGSQEMRKHEVASEIDEILLAYVDIVIFANRPETCNSVELSHYFKEFVSIFIQYCLAINHTNLLFRDIYYKFCEHSLGKVAYLESLEPYILNDKLTSLSAIVMKDFIEHYQNLGKVKEVESCLLHLDVTNLDIHQMVKLCWSHCLYDAILYVYNRGMRDYTTPLEELLGVLRSALNSGKQLSELDQALGYKMLVYISCSLAGRSYPLGEIPEDIVTLVKTQVFNCITAVHTRDAFETERSYPYLRILLEFDTQEFLNVLSIAFEEKEFDNDFRGEDNTSGRQYVVNILLQIMVQDTGFSPSQVGSLFTFLARQMAKHENTIHVNKVLFEQVLEYLANPDDDARHEERQQAILELLVAGGLRQFDDERILVLAENARFYRVCEMLYERKRQFAKVLSCYFRDSSRKDQAFRYIKSVMTDDIYADIEREEVKEAALNSLQELVSISCWQMANLVLTHFPDTLTSVVCSLEAQHKVQYEFLKGVFDSRSPVSRLEQTPDVEVHEKYIELMCQFEPDQAVFSYLRASDNYRIEETLSIVRGYSFTYAXAYLLEKAGDVHGAFQLLLETLNEKVKVVVVGFEKGHQYDELRKSFSDIWAVMLVITQLCQRNSARFDEVDREALWFPLLESVMAPQRKCHDTSTEYFQAFKELTRHVMNSMMGYISLPAILQKIMQDPTYSGGKFGEIKELILGMLDTYSYESTLLKTTNRLLEKDLYTSLSHLKSYLNKGIAPDAMRCGVCGRQYSTDVVPKDAVIFRCHHTYHQECLEGYHSSDTTDKMICVLCHKGKMSRVPSXKGKRPAKKTTTTEERATKGNTSRVEKSQPDMVRQQLELISRLRKQNQGPSRLAILSELSRTRDDSILSLSYGSSSSYSNSIFEHEGFRLKLVPPLPRPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDB6</accession>
    <name>A0A6P8HDB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitoguardin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitoguardin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553058.1">
        <property type="nucleotide sequence ID" value="XM_031697198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290194"/>
    <dbReference type="KEGG" id="aten:116290194"/>
    <dbReference type="InParanoid" id="A0A6P8HDB6"/>
    <dbReference type="OrthoDB" id="8880065at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019392">
        <property type="entry name" value="Miga"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508:SF5">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10265">
        <property type="entry name" value="Miga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553058.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="60298" checksum="E338916AB9B9ECBC" modified="2020-12-02" version="1">MYGGRKSLLFLLLTVGATGTLFWISALYFRRKRRQKAAISNEESLKTDEKPKGRALRASGLLTRSQLKNKLAKDGNENNSTRNAQYDSLRGDETCDRTAMIPDGRAADENFPSNSEELVDRFINQGVEEFGLALEHWYEAARYFLESKDQDMNRRRIEQEGTLRIMLSCSRQMRTALVIQGMAEDRXFAVAPKNVLSWIDSDAMIEQSVAEIAEKCSDDSDAESFVSAASETAALEFDDLIDERFISESAQLKMFRQTILKAAGQHSHLDFYVLGLEQYARCEVECRKMRTEVVGCESDMEFLAKVVCIRQASELAFSVAENCTWMAETGRFMLSSVIDAMGKDPANFEAAFDELIEYCAKPENLQQISDELMGRRVPVISFYDVPLDFILLDAFDDLATPPYSVATAIQNRWLSASIKETALTTAIWGVLKAKASYLENQYGFMAHFYVVSQYILPCLAWGFMGPDEELRDLCNFFKDQILGYIRDVFSFDAADYSTVTSLSESIIQLAKRRTDNLAQRLQQSSPINGLQVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDK4</accession>
    <name>A0A6P8HDK4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290797 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553761.1">
        <property type="nucleotide sequence ID" value="XM_031697901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290797"/>
    <dbReference type="KEGG" id="aten:116290797"/>
    <dbReference type="InParanoid" id="A0A6P8HDK4"/>
    <dbReference type="OrthoDB" id="5985758at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553761.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="73017" checksum="53EEB37D0281D60B" modified="2020-12-02" version="1">MTMTSRHRQSDNQVNVCYKHQDSSSTSFSNMTLPATTIYGTPPFSISPIFGTSPDTLYEHPGGAEVLFLNLNEHTVFDKVQSRRGGQARMRVINGVIEIVCRTPVQIMCIKAFVSREQEAAKLHGDENGRIELPVVMGKIMDVEDSPGFYKQFLSVNLDSVYEGPNKPVYELSKVEMETRNLFQLSIQVQYIGGLGYQEFKSVPFLMRTKPRTMKRKFEDENSLHSPDVQRTHHEIEMESPLYSSLPSNGGDPRTVEFDRVRILDHLEAKRASIDHLTFRVMTSPKNADIGYRFGLKHPVLREDFEEGDVVGFFKDNEGKTVIDLLDNNNVKDAFMAGVISRSAYIEAKQGFEKDNSDVVCVIGIVKVNCVGSIRAGERIYSSFNLDKPGMAMAESQLPPGAMVTKXGTLLGMAMEDSKPRNSDEERLVKCFVCIVMGIIDKQVAKEVESLYDHFNIQMTIRLRKERKRARQALCLIFSVLGVLLIGLAALAFELFYPGSALRVYICKMGSIKGHYSTFKYFPSQIMRTFEVYGMEFPSWPALQNKLHQLKNLPPLNATKVNTTKVHYYLNLDRCSYGGSKLATVLNLDPVKEVGGPIIYAIDQKCSRVYYYTDVYPEGWRNEESVKYYPKRLNCYPRSSFKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE87</accession>
    <name>A0A6P8HE87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Probable 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116291044</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554026.1">
        <property type="nucleotide sequence ID" value="XM_031698166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HE87"/>
    <dbReference type="GeneID" id="116291044"/>
    <dbReference type="KEGG" id="aten:116291044"/>
    <dbReference type="InParanoid" id="A0A6P8HE87"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="36"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031554026.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24188" checksum="08BDE38D86473BF4" modified="2020-12-02" version="1">MDRIVEIAKYSLVDIEDPVNLVPVVLISLCVFWSGRPVGLAWWAMFNGCLIHIYMDGIVGIFGRGPKWLVEQYGKLDVRYWQTQDPMVMTISAVEMVIMTPLCIIWYHSIVQKRWYCHAIAIMTSTFQLMGCIMYVGAEILDGFKHLPSNWPPRFDNFNDLFYFWFVFVCLNGVWVVVPVSIIVKSLYEMHHICSQLPPIKKKTSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEG8</accession>
    <name>A0A6P8HEG8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC116288381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551022.1">
        <property type="nucleotide sequence ID" value="XM_031695162.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551023.1">
        <property type="nucleotide sequence ID" value="XM_031695163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288381"/>
    <dbReference type="KEGG" id="aten:116288381"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18594">
        <property type="entry name" value="ABC_6TM_CFTR_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="829"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="142"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="460"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="774"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031551023.1"/>
        </source>
    </evidence>
    <sequence length="1411" mass="157911" checksum="EC7276D3AB95DF9E" modified="2020-12-02" version="1">MNHQEDQSGSVCNLDKKPFDKHNDDDEGDDDDGSYKQDDASADLLGGRKDSAGVIPTPMKAASFLSKYITLWWLNSFLSLGAKRPLEASDLYGLMTPDQTGTLCDKLQNEWENEVRRSQNNEKVKKPSLVKALVKAFGKGYAALGILAIFADGLRILQPMLLGQLITYFSEDSTMPARDAYLFAAGLGLCGFLITIFNTPFSYLRNVYGMRVRVACTSLIYSKTLXLSNAALASTTTGNIVNLVSSDTQKFDWTAPFLHYLILGPLEVVVVLVLLWYQIGMAAVAGMGLLICLAPMEIKMGTLLMTLRTKALIWMDERVKIMNEVIAGMRVIKMYTWENSFTEWITKLRKNELKWFLRTSLANGLFASFFFSSLALISFITFLTYVMSGEVLTASKVFTCVSLFNSIRVVMAMYFPIAIXLLNESKASLIRMEELLLLDEMQSKGLITSQLRPKXQDCTVKADNVTANWNKKIASPTLDDVSFEVKAGELLGVIGPVASGKSSLLMSILGELPMXSGTXNVKGKIAYASQQAWIYNSSLRHNIIFGKEYEEERYKQVIKVCALEQDIELLPEGDTTLVGERGVSLSGGQRARIGLARALYSDADIYLLDDPLSAVDANVGRHLFDKCICGYLADKPRILVTHQLQFLKQASKVLVLTEGRCVGQDTYQNLLQAGVDFISLTHKEEEEVALEHKHEEHDKIRHRFARNISRQKSEQGGVCLRSTKLIESNLSVMSAASSASVYKEDLLPEEEKQEGAVSAKTYLSYLRSFHNLGLGIFVVFLFAVCQVVAMCCDLWLAEWTNVEESYHVILQARNSSSNMSSPTRPDRDYYLGVYAALVFGLFVLSIICVELFFVMTIVASRNLHLKMLASTMRATMYFFDNNSIGRILNRFAKDISVVDDNIPWLLCDVLLTGFTCLGILFLVGATNPVTLVVVFPVIVIFILVRNYFMKSSREIKRIEAISRSPLFGHFSTTLLGLDTIRAFGVQETFKDQFISFQDAHSRAWFTYISGQAWLSFRLHILCVVFLLFVALISPVIKDVVGLSAGIVGLXVSYAIMLTATFQPFIEESAEVENLMTSVERIVEYYHLEHEAPQETDVKPPDNWPNEGQIEFNNMSFSYHKGLPKVLHHISCVIKXKEKIGVVGRTGAGKSSLLSTLFRLAEPTGVIRIDDMNIRDIGLKDLRRKLSIIPQDPVLFSGTMRKNLDPFNXHSDVQIWNALEEVQLKKAVEDLPDKLDEELAESGSNFSVGQRQLVCLARAILRHSRILVIDEATANVDPNTDTLIQSTIRDKFRNCTVLTIAHRLHTIMDSDRVMVLDAGRLKEFDXPYLLLKNHQSIFSELVDNTGPTEKRRLHDIARNAYTETKNAIPEIGNETDDDDDSKTATQNDVIIRVPNIGTLEQTSGTHFQSSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HER6</accession>
    <name>A0A6P8HER6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116288464</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551122.1">
        <property type="nucleotide sequence ID" value="XM_031695262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288464"/>
    <dbReference type="KEGG" id="aten:116288464"/>
    <dbReference type="InParanoid" id="A0A6P8HER6"/>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551122.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="26568" checksum="BC531AB163EF3776" modified="2020-12-02" version="1">MQINVQAGRYKYLWYTEGSFSSPNYPGPYPGDLHYTWFMPYTSKELXLEFVELDLYKCFVQERYRVCNDFDNVYIKGKSYCNWNRPSKPIIFLPWTQQSVVFTSSYSXSDCKGRGFKVKYRPVDQWNETSTLWPIPRTMMMTTTTTETSSEWSGKTPDRDIHCLVINDSKAMHRVHFQSYSPRALLVPFGHHQKRKKKRKKIQMQCIPKRMTEIAKEQAATWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HES9</accession>
    <name>A0A6P8HES9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116291236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554236.1">
        <property type="nucleotide sequence ID" value="XM_031698376.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291236"/>
    <dbReference type="KEGG" id="aten:116291236"/>
    <dbReference type="InParanoid" id="A0A6P8HES9"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033749">
        <property type="term" value="F:histone H4R3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF22">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="333"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554236.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="63825" checksum="BF602F87811344FC" modified="2020-12-02" version="1">MAEENLSDEKYFISSWPPESAVNSKGSPCKRTKYDQDKDTVLSKHVYIENSSKNSRQVDTGDRESEGKLVRKADKCDTILNLNKTNDSKDCLSWALPALAKWWKEKQKSLXISCEWKIPDSNNPKTILHHVSRLPEAKQFMMAQVKQLQKQVSSKPGCVGIHVTLASYYTKIRDLTKAEEALDNAHKLDPENKEILWMQAKVRRDKDLQEQTQKYKELMPPPKSKDLKMKEPLKVERRHHSTLDAREFLFKYALTGTPIIITGLXESMTEERWTIQYIKKVLGHKNVPLKKRVKESTEWAKLEHHGTMSVETFINSLHDDRKPSCLFDWSLSTFAPELAKQITIPRYFASDFLQRTEKSSMYQDSWPSLFIAPXGMITDLHVDSFGSNFWMALFEGRKRWTFFRKEDLPCLYPHCDQDFNIVFDVDFSNPDLKDFHLLSTVTPIQCMLXPGEILFVPHGSPHYVETLEDSLAVSANFIDLSNYKSALEELKVMGIIDPQAESLYNQLSDDNFPTKMWSEQKDMKWEQFKEWPRDDYEMYDIDLVDCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF78</accession>
    <name>A0A6P8HF78_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554401.1">
        <property type="nucleotide sequence ID" value="XM_031698541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291372"/>
    <dbReference type="KEGG" id="aten:116291372"/>
    <dbReference type="InParanoid" id="A0A6P8HF78"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554401.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45257" checksum="2B34B452ADBE9A3C" modified="2020-12-02" version="1">MALKTSFHMEEVTRTMLGRQLDFALLFRDSIWIRVXEQFLSYSVSEMPSVLEFIGAIITRVLFGVHAVLVIWIVLQLYSGYEAYWVVCTGLCFLAIETLFTLIIRKGQEYRYFWPSCFFYLCSLVPCVWILHINMLTSRVSGTRGATLLISGKTIDEGFVSKVAEIGLVLIIIAGRWILPRGTITRDQLSALLLEYIAIAADILELFGAFEEPKVEGNYPVTVAILSLYSWSLLQFTFSFTAFVDDDDEGEEEKEDKNQLHGDLFGILAAIFMQDGPFLILRLYLISALGVKGDLQIFFAGKNAVTLALLVYRLFSIQCLKKQDERTPYQRFRTASIAVVGVKILQSQTFHDKINFYNERDMKLETNKDASNKDTSDSPSPEASSPDSSPPVKQLAFEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFX3</accession>
    <name>A0A6P8HFX3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Reticulocalbin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116288785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551477.1">
        <property type="nucleotide sequence ID" value="XM_031695617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFX3"/>
    <dbReference type="GeneID" id="116288785"/>
    <dbReference type="KEGG" id="aten:116288785"/>
    <dbReference type="InParanoid" id="A0A6P8HFX3"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027947011" evidence="3">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551477.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="43136" checksum="C4979A5E277F2BD3" modified="2020-12-02" version="1">MFKNILLKLLLLGIVISLVVSEEKAEKKHEDHDEEEHDDDHEKVTPKDHEKDEEHHDEEEHHDEPESHEDEHHDEKKDDEHEDDEHDEKHDDDEGDHDEAKDDDDDDEEDGDDGGEHDSHGEEDAFLGDHLKDFKGLSAEDAKKKLKDIITNEVDLNKDGFLTEDEIRARLRATTKQNRMKELNSTMITHDEDKDGKISWEEFKKHHFTDGDDDKEQMKEDEEKFKYADVNGDGGLDLKEYMSFYHPGDDERMSAFVIAETLKKYDADKDGDLSKDEFFASYKDLNPDAKAELEKDFSNTYDKNKDGKLEKDEIRRWLFPDEDMPLEEPPVMIKEADDDKDGKLSMDEIMKNHKVFVDDPMANGGDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG29</accession>
    <name>A0A6P8HG29_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="10">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116291710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554781.1">
        <property type="nucleotide sequence ID" value="XM_031698921.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HG29">
        <property type="interactions" value="2251"/>
    </dbReference>
    <dbReference type="GeneID" id="116291710"/>
    <dbReference type="KEGG" id="aten:116291710"/>
    <dbReference type="InParanoid" id="A0A6P8HG29"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000149">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="12">
        <location>
            <begin position="216"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031554781.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="63513" checksum="B035127DE8960924" modified="2020-12-02" version="1">MAAPVAKIALRSPGGVFMVDGSSPFKESGKFERDTSPRCGVMTFSRDGSLFAWCNSSCITIVNTADGQVIQKIPRAKTSQLRFSPLGTYLSSWEPYAVTKENPAGIKNLEIWEVKTGNLMTSFSQKKLETWEPRWTDNEKVCARSVTNEVHCFHDGNFGTIAAKLRLQGVGSFEISRGPAPYTIAAYVPGAKGAPAYVRLYRHPQFDSPGAVLANKSFFKADSVNIKWNDKGTAVLVLAITDVDKSGASYYGEQTLHYINTSGESSMVQLAKRGPIYDVKWSPNSKEFGVVYGFMPAKATLFDIKCEPIFDFGTGPRNEIHYNPHGNIVCVCGFGNLQGWMEMWSRKDLKMINKFQASDTTMFEWSPDGEHILTATTAPRLREGNGFKVWHYCGSLLYKKDIPELYQALWQPFPVGVFPEKPVSFNKAASSMAVAQSPQPKAAYIPPSLRGTGMKTIKLHEXEPPQNKKNQEPVSKSAAKNKKKREAKARAKETEQVANQVLATSGPPAPTSAPSQPVAIADDKKLRNLKKKLRQIEDLKESQKAGQKLEANQLEKMKAEASLIKEIEALELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGN5</accession>
    <name>A0A6P8HGN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein IMPACT-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116289003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551735.1">
        <property type="nucleotide sequence ID" value="XM_031695875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289003"/>
    <dbReference type="KEGG" id="aten:116289003"/>
    <dbReference type="InParanoid" id="A0A6P8HGN5"/>
    <dbReference type="OrthoDB" id="5988257at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="120"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="279"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551735.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47065" checksum="49F40CCF20EB7593" modified="2020-12-02" version="1">MDYLVQIDMELVDVREGSIKLVLWVKELGALEKFWKRYETGELRKELARILITEELKFLADGEDVELEVSISEEEYKKAQEQLKAKEEEVLAQEXEAKMTIGEKPSHFEIFDGDIFEEKENKFQAHFAAITSENQVEQVLKKVKETPDVPGATHYIWAYRIFDAHKDDFDEGCNDDKDDDSGAKVLHLLQGTCAQNLIVIVACLYKTSPLDLGPNRLIYIYKGVLXLLLIHKVIRLNSKVKTFLKETEYTSFYKGXATTEDPSVIPXFDIKSGVPIEDRESTFQGHIADVTSLEQVPQVLHQLKQNEKIANATYNMWACRIYDEKKKSYFXDXDDDGEDRGGEKLLHLLKTSDASNVIVIVTRWHGGIPIGNDRFKHINDCANDLLQQRRLAAKLSTTSADPKEKKKRIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHM6</accession>
    <name>A0A6P8HHM6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box/WD repeat-containing protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555904.1">
        <property type="nucleotide sequence ID" value="XM_031700044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHM6"/>
    <dbReference type="GeneID" id="116292688"/>
    <dbReference type="KEGG" id="aten:116292688"/>
    <dbReference type="InParanoid" id="A0A6P8HHM6"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="386"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="427"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555904.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53722" checksum="35DC49F13F367E9B" modified="2020-12-02" version="1">MKPTLEALSDEILVGIFSFLSARDLCRCSKVCSSWCRLANDFHLWKNLFIKTFNRFVSDPSFYNNVTPSQWKELYILKSNWFSGHCHVQQLKKESPVHSDSVLTKVTCLKISKCGENILSSVNQGSKIVNIWSLEDKRGLHVVRCEGVVSSLDFGCLRSRNLLAIGLSCNKFCLWDFKLARYRLHQTNLNERSLEDFPILQNISPPFNLSDSTVVRVNLVDDKLATVTQDCIIKVWQLNFRPDGSVSCQPLHTLSTNKPRCSVLDIQLKHETVNGYWSVSISHAAEVLENWNLIGFQSLKFQGINLVNFESPVITPAIHYTGFNTDIDYHLEDKQEYKRQQQESMSSRTFISCLSISPCTKLVTSGQNDNTISLWDTSTKTRRHTLFGHTGSVTCTDVDRHKVVSGSNDRTVKVWSLESGDCQLTLPEDHSSGVSCVTFNDQWVVSGDNSGEIKVWDFAVNSLSVLQSQDSTELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHP4</accession>
    <name>A0A6P8HHP4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289335</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552085.1">
        <property type="nucleotide sequence ID" value="XM_031696225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHP4"/>
    <dbReference type="GeneID" id="116289335"/>
    <dbReference type="KEGG" id="aten:116289335"/>
    <dbReference type="InParanoid" id="A0A6P8HHP4"/>
    <dbReference type="OrthoDB" id="10275738at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552085.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33099" checksum="CDA67635B11305E5" modified="2020-12-02" version="1">MMENSIVFIIGLILNVLVLCYCCIKWKTIGNIKFLVATQAILSSLTISANPGLMAENIDWHPKGDFICYKLPSLVIHFLCVAILNLACLSCISYAQITDTWQVRRSSAILIFLAVVSVSTILSSPIFYSINKGWSILRYDGCISKISDAEVANKVHINVVRYAFWFLILQYIIPAFIIASRVVLILIHLWQEESKTDISPRPKNQVVIRFAVHAIFAILFLVVIVLFSIHLGGLESDKALAFLNVIFHKFVLFFVVVLCCPWYLIEMIRSQCENDESSCPVEYTKQENELNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIK8</accession>
    <name>A0A6P8HIK8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291683 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554743.1">
        <property type="nucleotide sequence ID" value="XM_031698883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIK8"/>
    <dbReference type="GeneID" id="116291683"/>
    <dbReference type="KEGG" id="aten:116291683"/>
    <dbReference type="InParanoid" id="A0A6P8HIK8"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554743.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11257" checksum="80E1AB73FB0A710B" modified="2020-12-02" version="1">MPDKYEETIYSEIIGTKKLVSGNESAAGASNDIPLSDMHGQGTETESNPSDQTADPAKQNDQKPATDEKEKPPDNQVQPPTKEDSADSLPNLNGRNNTTLTTVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIM1</accession>
    <name>A0A6P8HIM1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116292496 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555696.1">
        <property type="nucleotide sequence ID" value="XM_031699836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIM1"/>
    <dbReference type="GeneID" id="116292496"/>
    <dbReference type="KEGG" id="aten:116292496"/>
    <dbReference type="InParanoid" id="A0A6P8HIM1"/>
    <dbReference type="OrthoDB" id="10377041at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028080735" evidence="2">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555696.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24108" checksum="3E7DDFEEC7FF5A6A" modified="2020-12-02" version="1">MASIGFQILSICLLLNFFEIVQQDKVYLIKGPKHINGSIGEDALFMWNTTDRKEILAVSWGIRKGNIPDPQFISVDGYHRRVTKNKDIGETLKRRVEFLGNLTMGRAWFVLKNLTVNDTNEYIASISDDESSDIPYCVRLNVTEKRKEKPTEGPSPTPDTTAAAPNNTRAPTNKTNTFSNITTPPEPNSSNIQRHINGYTILTDIALVLWHFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJI7</accession>
    <name>A0A6P8HJI7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116293281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Deltex family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031556544.1">
        <property type="nucleotide sequence ID" value="XM_031700684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJI7"/>
    <dbReference type="GeneID" id="116293281"/>
    <dbReference type="KEGG" id="aten:116293281"/>
    <dbReference type="InParanoid" id="A0A6P8HJI7"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Deltex C-terminal" evidence="11">
        <location>
            <begin position="115"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556544.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25351" checksum="756713C37ED7265E" modified="2020-12-02" version="1">AERVSQKESLELDGSKLTITLKEIPKEISKDPNKLHVTGISEKTNKDGFESFMEVVSGVEVESFFFGSNYNAMVAFKEPPVLPKCKHKFCKKCIDLAFQHRKACPTCGMTYGVHTGNMPQGTMHHSLEPYLRLPGYERYGTVRIDYNFPSGKQGPEHPNPGQRYSGTSRTAYLPDCSEGREVLDLLQKAFNARLTFTIGRSVTTGVFNVVTWNDIHHKTNPYGGANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJW6</accession>
    <name>A0A6P8HJW6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Visual pigment-like receptor peropsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555178.1">
        <property type="nucleotide sequence ID" value="XM_031699318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJW6"/>
    <dbReference type="GeneID" id="116292083"/>
    <dbReference type="KEGG" id="aten:116292083"/>
    <dbReference type="InParanoid" id="A0A6P8HJW6"/>
    <dbReference type="OrthoDB" id="5955346at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="32"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031555178.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46990" checksum="0B98FEBBF60CC97B" modified="2020-12-02" version="1">MSGIDSTVAFDHNISTFFSISIGVLFVLGVSMHVLSLKVLLHHEHKSRELTPYLVNVCLSNFVCLLLQFPLVFVASIQKGWTFLGSTSCYVVGMTCFASSTVVIFTLASMSVKIYHSVINQDMGHHEQSFLRKFVFIWVFGFLIFIPTLFGWNSIVSDGPFCTVNWHAESFLDASYLFVVAFVSFVIPLVVCCLYCIKTSRYVSRDTHHVATFTMQQIRTRALYISAGKLTAVVLSLFFIFWLPYWIDGFCTLFAVRRTKPASLAVLCWLFVSISVVYSPMVFTLMNKRFRRSLAKMLWRQRSHRRVNPRISVDRFESSDAALSSCQITTRACSPTNFVPRSPLVNRSFKMSVFEDVTSEIVSQQKTLQRPELTNEAVTRLIRSSLHAAHELHEDYASHDGEHEQRRKTTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKI9</accession>
    <name>A0A6P8HKI9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GATOR complex protein DEPDC5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556889.1">
        <property type="nucleotide sequence ID" value="XM_031701029.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HKI9">
        <property type="interactions" value="2120"/>
    </dbReference>
    <dbReference type="GeneID" id="116293584"/>
    <dbReference type="KEGG" id="aten:116293584"/>
    <dbReference type="InParanoid" id="A0A6P8HKI9"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055213">
        <property type="entry name" value="IML1_double_psi_beta_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23013">
        <property type="entry name" value="IML1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556889.1"/>
        </source>
    </evidence>
    <sequence length="1612" mass="184661" checksum="52BB8BA8469F05AF" modified="2020-12-02" version="1">MKLFKLWVHQHTFSEDDLIINPKEFPDGRVGDVLEIFHPEDQGSARLLLQINSISDFQQKDTVSIEQSVANLFQLRTYSNVNVKKVDPDEVSVDLVDVLVKEQYLSRNDMWRLAKALVDKCVYVSKKVSFSGIRGQINELWKKGKQKTCGVISKDTKVVFRSLTAEIFLFIQMSQEMWDFELNGDLYFEKVINGFLHELFTKWKDLKSNHEVTIVLFSRTFYDCKSIDSFPLEKRGSILQDPYGRFYEDFYQVLVQEERRDDWLPVLVTLKYHFNQYPKYINCCQDIPGMPTGNNSTAFEGNFLESINLTMNIFEKNHLDRSFDRTGQTIVMVTPGPGVFEVDRSLNSITKQRMVDSGVAVDLVCMAEQPLHSVPLLKFYNKDGDCRVNIGDDYNIPHWMNHSFYTSHKAKNKHDSFRPRVKIPDVVLNYFNVKPEENPYMKGLHKNFLPMNAKDQLANQIPDFINYKEYDANVFRAATSAKQKAKNVDRGKSSRSAPSFSRPNSSSDLEKLNKSRDDGNVIREYSPRDSVNGAISIPSSSRSPARHSQTDITKYRISASMDHTIYAQLSKGYSPGHQNDDDEFRIEMDQVVVGSAGAPRHFPRFLSRVTHDPRRTLFNPFKPLDIPCRWTCNRHRWAHCFPIGPDGESIHRHFEKQNEKKDDDTPQKPKAAKEATLGVADARKRIITIQSQDSDEFEEEDEVYEVEDPDDAEVARISLSTESGERSFLDSLNEPPVLQEVQKKGSLETPLTPDRGSSLRRPRAPVRTSFFHHSSKKVEHDWTATITTSVDWESLVLPACLPLTSEYCPDMKTLGNDYLEFHYELCVGDDDEYAMSRQRCTSNPARMEQSRHPVSAQSMILELVAQRLSKGFQILTNPPYQERGQSYYIAQNDEFESEECFLSLGRNIHRLSVIPKRSQISVTRYRPRHVRREVNPIQYRYRLWARHAKQYYYKEAEFQHDELDKYNWNYLDQHISGDQDFTALVESLRYWKARFLLLPDTNYKRYNCEEKKGDRKNTNEEDSRIEGILKYLEMLNGIKRSKARRRPLSPNVKILPKNGSRTPEPRKEQQQQLPGQDAAVKKDEKGTAPISEKDTTESQSSPENTSETAGSATDESADDAQEGTLNKTSPLESIAEAMLDESNSFPFLPPTKGLGSACFLSIEAIWWMMHNIGLDDRKEAVALAQKMVDAKIFQHASGSSRQKFVCGFAIFSXTAKEKWNEKEDTSDKKRSQRMYQSSVMLDLPLEHFQEDWFEVAISRPKPPSRSIPAFLVPDQELPEYLESSPLFRQGAFMRSRGRSFQNSMSDDCGNGPPYKTVNVNCDAQRKSERPEWAVVRYHGNYCNTHAFEIEVHWIETTGSVVSDLIQAWARKATSCGFHLIPAPVSPFPDPLGFSFNPFRLPVYIPVLLSACQDQGQENIFLGFGPSTYRPRKFLFLEAILENFGFIKDSPYGSSQNIYSFFAPPVQCRAADYVHSSGAAFARIHDQDTSAKPELYGFGPGDGSPPEGSVGFFWMDNYMLTKRWRSAATGDVEFVRKLMADFVDFCSNKNGELKAFWDDSWGSLINASQDLSEQETSTDTADNSTISVPHMEEKETAEEVNTKKEVLLDGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM04</accession>
    <name>A0A6P8HM04_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cotranscriptional regulator FAM172A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116290711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553672.1">
        <property type="nucleotide sequence ID" value="XM_031697812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HM04"/>
    <dbReference type="GeneID" id="116290711"/>
    <dbReference type="KEGG" id="aten:116290711"/>
    <dbReference type="InParanoid" id="A0A6P8HM04"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="310"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="469"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031553672.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63850" checksum="FDDDB1E4D82B697A" modified="2020-12-02" version="1">HVHGNEVTVLRDKKTKERFKFNVYQDESKNQERYVKLGEAVKNYVHDVCLSGNLKLSKIAIPVDAGKKEPQGFYFISEYALYFKKLIILMHGGGAVRAGQWSRSLIINENLESGTMMPYIEKALEEGFGVILTNGNHNMDSNDRPIQGSESAQDHFVYVWNKFIKDAKAEHIVIVAHSLGGEVVLHGLREIDEARRRINAVAFTHSTHTTIKESTEIKRWLKENARNWVCSEEPLDTPVKIDCKDDCDQVSAGTNEHTMTSHLAKDSVFNFFEEKLSAASSFIKPTQLTRIPLQYQPHELDSVYKMTSSPRGLAVIVNMNNFQPKARVHNRKGSEKDQQGLVNLFEELDFRTKTLVDLTKEELLSEFQDITKYHFGAYDCLIVCIMSHGDEDYFVACDGGKIKTQSIREMFNNKNCETLCGKPKLFFINTCRGELEDPGTVVKESGSKLSVKPQPSPEPKAYTAVENCGRETTAENADILTAFSTVEGYCSYRHEEEGSWFIRSLIEVFREYAGVEDVTDMLIRVNKEVNSKGSLGSKQVPEPRNTLTKKVFFWPGMKFKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNA9</accession>
    <name>A0A6P8HNA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THAP domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="RefSeq" id="XP_031554160.1">
        <property type="nucleotide sequence ID" value="XM_031698300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNA9"/>
    <dbReference type="GeneID" id="116291169"/>
    <dbReference type="KEGG" id="aten:116291169"/>
    <dbReference type="InParanoid" id="A0A6P8HNA9"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554160.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21715" checksum="874C3F8ECCB1404C" modified="2020-12-02" version="1">MFGLLFRSVRRPFCFELSKTMSSQASSKPPIDQALTPISWLIGKWKGEGCGIYPTISPFTYLEEVTFDHFGKPILTYDAKSFSTTDQTPMHYESGFLRIKPGTTTLAFMVAQNAGISEVEEGEVKDKEIHLLSHTIGRMTFGADPKVTKVERIYRLTTDQDTMEYIMHMETDRTPHAQHLHITYKRVKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNP7</accession>
    <name>A0A6P8HNP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293368</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556648.1">
        <property type="nucleotide sequence ID" value="XM_031700788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293368"/>
    <dbReference type="KEGG" id="aten:116293368"/>
    <dbReference type="InParanoid" id="A0A6P8HNP7"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF35">
        <property type="entry name" value="SEPTIN-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556648.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50488" checksum="8023B720AD131351" modified="2020-12-02" version="1">MGGSDSKIVYETVDRSDPRARQLGIRAAREENDRKVREMEEELRQMKERELSSALEDVRLQNLRDAHGRAEAKRREEELKAERLREEKEQKEKIACIKMKQELLTYKFGNKLSLKTFESEGLDVSDMKRVVFALFGPTGSGKTSFIGTAERVLLGSHNQTAFEQGAGEEGTVLLQEFLSALNINLLDTRGFWDINNDTASECLNIMTGKTRESDVIVRNHDTEELGEXADVSARSVAKFGEQVHAVIFVIQAHDRRLKEGMYLERMKKIRDHFRFEGHSPITVITCEDKIKNDEDREIAFEEASAATGSPIDRTFFITNYTSQKNVYSLQTEKQVLDILDTALLSAERFVLIQKLREMHHGRSEGAGASSGSAVNKTVRQFFKHLQVKYDWNSDRVAAIIEQLEKEEIKTVDTLKASWDDVKKEIKMTIGIKQGVEKALRDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP82</accession>
    <name>A0A6P8HP82_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Max dimerization protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116294056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557446.1">
        <property type="nucleotide sequence ID" value="XM_031701586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HP82"/>
    <dbReference type="GeneID" id="116294056"/>
    <dbReference type="KEGG" id="aten:116294056"/>
    <dbReference type="InParanoid" id="A0A6P8HP82"/>
    <dbReference type="OrthoDB" id="5981879at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF99">
        <property type="entry name" value="MAX-BINDING PROTEIN MNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="60"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557446.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40120" checksum="86CCFA6F6553A67A" modified="2020-12-02" version="1">MSLDTLLKAAEFVELSSGPKKKENLSNARGNHPNNVYADRRRVVSESEAAERRRRPGGAGTRETHNKLEKNRRAHLKECFDILKKQVPSLEEKKTSNLNILRGALKYIQNMKKQEQEYATECDALKMNQKSLEERLNALKSNTKIKTEQKSSSSETIDSEVSQASSSSVQTLSATTAAAKTTGESRTLPISVATQTPSSSQLGTSVNEEDDEVSTTRISTSSTDTGGEGDESEHKLSTFDDNEDEKTDTDEGLSIDEEDIDQDIEIDVVGGQDDCPSTENLHSAVKEKSAHSNKMNGEVEEGSKRKVEEIPKGRYHNIKSRKRSKSEAAVKNEEDSDYDENTKEEPKAKIQACARKFRSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPH4</accession>
    <name>A0A6P8HPH4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031556973.1">
        <property type="nucleotide sequence ID" value="XM_031701113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPH4"/>
    <dbReference type="GeneID" id="116293654"/>
    <dbReference type="KEGG" id="aten:116293654"/>
    <dbReference type="InParanoid" id="A0A6P8HPH4"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="MCM OB" evidence="3">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556973.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19761" checksum="CAE4DAEDC68B37B7" modified="2020-12-02" version="1">MDVADRSSGTVTVRDELAERCQKLFQDFLEEFKEDGELKYLADAQELIRPERNTLVVSYSDVEAYNAQLSTIIQEEYYRVFPFLCRGVRNFARDRGEVPTNKEFYVSFVDLPTRHKIRELTSQKIGSLLRISGQVVRTHPVHPELVTGTFVCLDCQTIIKDVEQQFKYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPQ1</accession>
    <name>A0A6P8HPQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291584</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554617.1">
        <property type="nucleotide sequence ID" value="XM_031698757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPQ1"/>
    <dbReference type="GeneID" id="116291584"/>
    <dbReference type="KEGG" id="aten:116291584"/>
    <dbReference type="InParanoid" id="A0A6P8HPQ1"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554617.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16984" checksum="2881FB484F9E0B1E" modified="2020-12-02" version="1">MDELNNSFPQNYHVCKSPPYDYVEPEQNQKIKQDFRTAEGPESSSMYGSLLGNMPHVYSSLQVPHKTKEGNADGQEKCVDSSMYGSLVEDIPHVYSSLQVPHKTQEGNADGQKKTLESSMYGSLVGNALHVYGSLQEPHETYKHDTFDSPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ30</accession>
    <name>A0A6P8HQ30_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294920</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558474.1">
        <property type="nucleotide sequence ID" value="XM_031702614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ30"/>
    <dbReference type="GeneID" id="116294920"/>
    <dbReference type="KEGG" id="aten:116294920"/>
    <dbReference type="InParanoid" id="A0A6P8HQ30"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031558474.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18678" checksum="43C6D65BC3E3378A" modified="2020-12-02" version="1">MEADVPYVMQTNLQRCYIIAFKSTYLLCNGSWNILDNDFVNSRFLIVESENTQNFTIQFKRTTSHLEYNDAMKGRILRMTIGCYDKSDTIISDCLLLKMQGTLKCPDFSLPALPKPTTSPWTIAPTSETGTSKNEFQTHSISTSQSTTMVSKTIPSQILALVHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQD0</accession>
    <name>A0A6P8HQD0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein CDV3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDV3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554847.1">
        <property type="nucleotide sequence ID" value="XM_031698987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQD0"/>
    <dbReference type="FunCoup" id="A0A6P8HQD0">
        <property type="interactions" value="1629"/>
    </dbReference>
    <dbReference type="GeneID" id="116291778"/>
    <dbReference type="KEGG" id="aten:116291778"/>
    <dbReference type="InParanoid" id="A0A6P8HQD0"/>
    <dbReference type="OrthoDB" id="6288097at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026806">
        <property type="entry name" value="CDV3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284:SF13">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15359">
        <property type="entry name" value="CDV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554847.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32555" checksum="B6E45045D5832368" modified="2020-12-02" version="1">MSRVDLSPFGRALRSTCESSKEREKREDFYSSLIPNFCLYSPRHSAREPYTSRTMSDDKSLEDFFAKKKAKKGKNKNKFTTSDVITKQVSQPKKDESKDQSSKKFAATNQAISGKEDEEWIDFQQPQEKDYSGLRIGTLQISDKQEQEANEEEEREEFNEDGELLAKKEKASPWQQATAQQTVQASKPEEKEMPNVVGNVYRPPGAYKPPGMRNKLAMSGGVKGKAPEINSEIAFPSLQAAVQDSKSKEPAGSRSFETVKHGSRSSDNPVDRRPKLDLENKYDALRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUE3</accession>
    <name>A0A6P8HUE3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031556330.1">
        <property type="nucleotide sequence ID" value="XM_031700470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUE3"/>
    <dbReference type="FunCoup" id="A0A6P8HUE3">
        <property type="interactions" value="1032"/>
    </dbReference>
    <dbReference type="GeneID" id="116293077"/>
    <dbReference type="KEGG" id="aten:116293077"/>
    <dbReference type="InParanoid" id="A0A6P8HUE3"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556330.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31216" checksum="672C9B13CECEF42F" modified="2020-12-02" version="1">MLYLIGLGLGDAKDISVRGLEVVKKAKSVFLEAYTSILSVDKLALEELYGREVILADRELVEQQADIILQDAKSEDVAFLVVGDPFGATTHTDLVIRAREQNIPYKVLHNASILNAVGCCGLQLYNYGETVSIVFWTDDWKPDSFYDKIAANRKRGLHTLCLLDIKVKEQSVENLMRGRKIYEPPRYMTVSEAVKQLLEVPKLRNLNKEEAAYDETTLAVGLARIGSNEQQVVFGTMKSLLSHDLGPPLHSLVVPGEMHFLEKEMLYRFAVDINTDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUL2</accession>
    <name>A0A6P8HUL2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116296256</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560114.1">
        <property type="nucleotide sequence ID" value="XM_031704254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUL2"/>
    <dbReference type="FunCoup" id="A0A6P8HUL2">
        <property type="interactions" value="3120"/>
    </dbReference>
    <dbReference type="GeneID" id="116296256"/>
    <dbReference type="KEGG" id="aten:116296256"/>
    <dbReference type="InParanoid" id="A0A6P8HUL2"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032924">
        <property type="term" value="P:activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10491">
        <property type="entry name" value="MH1_SMAD_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10985">
        <property type="entry name" value="MH2_SMAD_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF25">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="227"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031560114.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47390" checksum="4F44ED0B8270F1FD" modified="2020-12-02" version="1">MTSLLPFTPPVVKRLLGWKRGGDEDDKWAEKAVKSLVKKLKKTGGLEELEKAITNPGIPTKCVTIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLQSHHELRPIEACDYAFNLKKDEVCVNPFHYQRVETPVLPAVLVPRQTIDTPHELHPIPEYTRPDNMSFPTQEPTNTFQLPETPTGGYMSEDACSDMSGDQQQNMQTDQQLSPAPEAPLIDAQPIQYTEPACWCSIAYYEMNTRVGETFHASQPSLTVDGFTDPSSSDRFCLGLLSNINRNPPIEMTRKHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYNWHPATVCKIPPGCNLKIFNNQEFAQLLSQSVNQGFEAVYALTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSAPCSSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUR6</accession>
    <name>A0A6P8HUR6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295382</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559038.1">
        <property type="nucleotide sequence ID" value="XM_031703178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUR6"/>
    <dbReference type="GeneID" id="116295382"/>
    <dbReference type="KEGG" id="aten:116295382"/>
    <dbReference type="InParanoid" id="A0A6P8HUR6"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028006599" evidence="2">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559038.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="21918" checksum="4E8239B7DCFCD76F" modified="2020-12-02" version="1">MKTILLLLIFAGFSFQSLISAPINQVGSLDEKDALKAPDGELLKRSKQHGISSSIDHLQELGTLDEAVLNRKDNGLPAKRDPWRRWRPNKRWRRKKQKSRCRRKEIWMDGCMDGWIRSTMEPTTTTTTPTAAVQDVSVNATGEPATSTITPATSTMEPTTTTTTPTAAVQGDVSVNATGEPATSTIAAGANKQQTRQQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUX1</accession>
    <name>A0A6P8HUX1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Doublecortin domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556470.1">
        <property type="nucleotide sequence ID" value="XM_031700610.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUX1">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="GeneID" id="116293210"/>
    <dbReference type="KEGG" id="aten:116293210"/>
    <dbReference type="InParanoid" id="A0A6P8HUX1"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17071">
        <property type="entry name" value="DCX1_DCDC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16113">
        <property type="entry name" value="DCX2_DCDC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF11">
        <property type="entry name" value="PROTEIN RPI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556470.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44360" checksum="B468FDA800337DB4" modified="2020-12-02" version="1">MASTTVTVYRNGDPTYPGKKLVVNRRQIRTMDALLDKVTKDVKLRTAARTIKTPTGGHTITKLDSIEPGGCYVAVGPESFKRLPYTEIKVQAKFNPKKDVEITPVKHSRLQMSARARKVADAEPSTHKIIFVYRNGDDLYPSCKMLLDKRALTSMDNVLKIVTSKVHLQSGAVFWLFTMEGREIKEPSELENGGQYVAVGHGKKFKRVAYNDQGSSLTPRSKAASKNXYKVPQVNRAKHNRSTSKNTHPQTNKTLQRKSSTGGSSSKASSVLSPRENYPGKQEQPIKEEVQEKYIRTPPLEEPIEEETQEEFISQPPVEELSSQSPTDEVYKASGKEQVKAKEVQDDKDVKEDKPIDQMPAEEVEEEDIEEVNETENNDNNDDGQKEDGEKPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVG6</accession>
    <name>A0A6P8HVG6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule-associated protein Jupiter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116295621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to all microtubule populations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAP Jupiter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559366.1">
        <property type="nucleotide sequence ID" value="XM_031703506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVG6"/>
    <dbReference type="GeneID" id="116295621"/>
    <dbReference type="KEGG" id="aten:116295621"/>
    <dbReference type="InParanoid" id="A0A6P8HVG6"/>
    <dbReference type="OrthoDB" id="10071234at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033335">
        <property type="entry name" value="JUPITER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34930">
        <property type="entry name" value="GEO05313P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34930:SF2">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN JUPITER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031559366.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14026" checksum="837E643E608CCA8E" modified="2020-12-02" version="1">MSSEFVVGFDDSHRQSRVLAPPGGKDSVSFAAAQASDPSGKPLNPCQVQRNSSNVFEASEMGIQSKGNVKSCQEARQKSSVFTAPLEPIPVPKKAHQEKSSGNIIAATEAAPEKIHTSVQVKAPPGGVSHISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVR2</accession>
    <name>A0A6P8HVR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mismatch repair endonuclease PMS2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116296599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560499.1">
        <property type="nucleotide sequence ID" value="XM_031704639.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HVR2">
        <property type="interactions" value="2876"/>
    </dbReference>
    <dbReference type="GeneID" id="116296599"/>
    <dbReference type="KEGG" id="aten:116296599"/>
    <dbReference type="InParanoid" id="A0A6P8HVR2"/>
    <dbReference type="OrthoDB" id="10254304at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000032">
        <property type="entry name" value="mismatch repair endonuclease PMS2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="226"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="710"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031560499.1"/>
        </source>
    </evidence>
    <sequence length="897" mass="101233" checksum="4E704CB71CBE3A9C" modified="2020-12-02" version="1">MDDEEEXRKDAPSVLPIDRRTIHQICSGQVVLNLATAMKELLENSLDAGAKSVDIKLKENGAELIEVSDDGHGVEPQNFEALTLKHHTSKIRDFSDLSAVETFGFRGEALSSLCALSNLSITTRHKSQMAGTKIEYDHSGRILSKTPCARQIGTTVTLTNLFSTLPVRHKEFQRNVKKEFVKLVHVLNGYCLISSSVRINCTNLIGKNKKMTIVSTTGGDQIRDNITCVFGAKQVQSLIPFKQMEPSEEELNEFNIPNSQSTLYEITGYISKXDHGLGRSTADRQFFYINKRPCDLLKVSRVVNEVYHMFNRHQYPFVMLDISLQRDAVDVNVTPDKRQVFMQEEKLLLAIIKSSLKRMFDTGTSSYEVNQKPLSQMNLSFIKNDKQTTRNENNESDGLIARSLSVQTFPSLKSFKRPFSXIANDSDVNRKPKQAKLTXFSQETSISNCEGLNNSLELKSKDEISCESCAVFVCEKSQESRENIAKDASTVDVNLDDEVQIIKQEKEVQNLEAEERGSENFEMKHSNPDVIDLSIEPVKTSLVDGKSVQDNSESQGRITTVDVVLDDEVQITKQEKEVQNLEADDRESKNFEVEDSNSDVIGLSIEPVKTSLANGKSVQDNSESRGRGTSDKGIRTKSRNLKEIIKTRKTMHVDFNIEKLQNTGXSRMIQQNLERTARIFRAKISPENNTAAEDELTKNITKESFAEMEILGQFNLGFILTKLGEDLFIIDQHASDEKYNFEYQQKHTSLNSQKLIVPRNLDLTASGESVLIDNIEIFRKNGFEFEIDESAETTKKARLVSVPVSKNWTFGVEDVEELLFMLSDSPGVMCRPTRVRKMFASRACRMSIMVGTALTREQMRTVVNHMGEMEHPWNCPHGRPTMRHVINLSMIAGVKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX19</accession>
    <name>A0A6P8HX19_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116293869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX59 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031557230.1">
        <property type="nucleotide sequence ID" value="XM_031701370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX19"/>
    <dbReference type="FunCoup" id="A0A6P8HX19">
        <property type="interactions" value="1113"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116293869"/>
    <dbReference type="InParanoid" id="A0A6P8HX19"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23022">
        <property type="entry name" value="zf-HIT_DDX59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="246"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="438"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="11">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031557230.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="71728" checksum="351C3A66AB73EE75" modified="2020-12-02" version="1">MADKMAAFVPRAVRRKDGKNNIKNSLKRKPTSQEKQEKSKVHIVDLREKCNSAASIPIPDKVSKENANLEDDDEEEVEEEIVSYSKNQRWPDQDEPVCVVCGRYGAYICDETEKDVCSLECKAKHLKTLGISVKTLISSPKQFQDETTNICSLSTSSNSELNYNESDVGTENLSFQNYKFKEHPTISSLSETKVQHLLKSLEIQTKGNNVTKPILEFFHCQFDKLLSENITKCGYFSPTPIQMQLIPVALSGRDIIACAQTGSGKTAAFLLPMIARIHSITDKLLPKSALLRTPLGLVLAPTRELCMQIEDQAKEFMQGLSNMRTALLVGGMPLPPQIHRIQMGVQIIVATPGRLLEILSKVNLDLTNVKCLVVDEVDSMFQLGFEQQVQQILENLNEAKQTMMTSATIPPNVETMASKLLRDPAFISVGNPNAPTQAVKQLVLWVEEKSKKKHLFSILNDSKHFKPPVVVFVDSKIGADMLAEAIQKMCKIPCVAMHGDKKQEERTQILQSFISGEYPVIVCTGVLGRGVDLLNVKQVINFDMPASIEEYIHQVGRAGRLGTSGWAVTFINNQNKHLFLDLIETLSPLGVSLPSELTNSFYAKQQKERKKQKAKDEKDEIVHQGNLIDLLKKSTERRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX74</accession>
    <name>A0A6P8HX74_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Adenosine receptor A3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116296985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560979.1">
        <property type="nucleotide sequence ID" value="XM_031705119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX74"/>
    <dbReference type="GeneID" id="116296985"/>
    <dbReference type="KEGG" id="aten:116296985"/>
    <dbReference type="InParanoid" id="A0A6P8HX74"/>
    <dbReference type="OrthoDB" id="10333329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031560979.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48037" checksum="6BACD6183A26B69A" modified="2020-12-02" version="1">MWTSWIFVAETVVIVTGNVTLLIVFTRTPALRKRKHYLLINLAVADFLVGVISVPMYGTMPLISYTRTANIMYQVQDILFGTASVFGLAAVAIERAYAVYFPFKHRTLWKGVYMIGMAGIWMMALLFATSEIYADNFVNVIIIAVILISLFTVIFSYTVIWIRMNCMSPISSNAIPRRDRKLTVTLLIVTVISLLFPFLVLNVMSFFDPQSLGSLGNIVMATKFCHYGNSLINPIVYALCMPDFKRALRMQIVCCDSIRKQAAFLHESREGNKVSDGTYQEHRLENYHGNYNEDHDKTSKHHGDNNAHRDKTSNRHGDNNAHWIRLPAITMETTMQTVIRPTIAIETTVNTVKRPAIAMETTVNTVKRPAITMETTMNTCEKTASNHHGVNTNISSTRMDEMRTLTTLAVDNEGFVNETNQDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZN9</accession>
    <name>A0A6P8HZN9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116294648</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558145.1">
        <property type="nucleotide sequence ID" value="XM_031702285.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HZN9">
        <property type="interactions" value="2796"/>
    </dbReference>
    <dbReference type="GeneID" id="116294648"/>
    <dbReference type="KEGG" id="aten:116294648"/>
    <dbReference type="InParanoid" id="A0A6P8HZN9"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000096">
        <property type="entry name" value="ADP,ATP carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="111"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="210"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031558145.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33269" checksum="1A35BA8084462C92" modified="2020-12-02" version="1">MPEKKQLHFIENFALSGAAAIISKTAAAPIERVKLLVQNQDEMLKSGRLXSPYKGVIDCTVRTFKAEGLLSFWRGNLANCIRYFPTQALNFAFKDQIKAIFKSKKSDSYAVKFSKNIASGGAAGAMSLTFVYSLDYARTRLANDAKSTTKGGGERQFNGLIDVYVKTLKSDGIVGLYRGFVISCVGIVIYRGFYFGLYDTLKPVLLGENANLVASFMLGYIVTVTSGLASYPIDTIRRRMMMTSGEAVKYKGSIDCTIQVIKNEGAISLMKGAGANILRGMAGAGVLAGFDKFQQLYIYWRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4R0</accession>
    <name>A0A6P8I4R0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296078</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559892.1">
        <property type="nucleotide sequence ID" value="XM_031704032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296078"/>
    <dbReference type="KEGG" id="aten:116296078"/>
    <dbReference type="InParanoid" id="A0A6P8I4R0"/>
    <dbReference type="OrthoDB" id="6020762at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="183"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559892.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50771" checksum="43B3A82D64F5DF86" modified="2020-12-02" version="1">MFCSSCGKPVNDGDRYCAQCGQGVASSSNLSQPGSSNCTGNQQSDDSDSSLGGLEEENDEEEAIKYYFNCGFNYQEILAFLAKRHGISLSYSTLLRRLKKHGSNRRGIANSTEFNDTLLKVQKRISEIITGPGSSLGYRSXWHTLEMEGLRVPRKIVQDLLKEMDPEGTELRKKHRLRRRCYRNPGPNYAWHMDGYDKLKHWGFPIHGAIDGFSRKILWLKVTRSNNSPIRIADYFVQTVIKHEGCPVELVTDLGTENGLAASIQAFFRDNPDAHRYVSSPRNQRIEGWWSFFSKNHSIWWRNFFRDLESQGIIDTSSDLSMELLWFCFNNILQEELDMIKEHWNTHSIRRSRHETVPGRPDSIYFLPELNGGASNLKLDVPIAEINYALQHVVEDENPDESEYQDYFDYVKSNLLFSMPKNWKEALNLYNLLLRVSENGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5Z1</accession>
    <name>A0A6P8I5Z1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polycystic kidney disease protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116299488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564009.1">
        <property type="nucleotide sequence ID" value="XM_031708149.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299488"/>
    <dbReference type="InParanoid" id="A0A6P8I5Z1"/>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="959"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="10">
        <location>
            <begin position="43"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="12">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="12">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="12">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031564009.1"/>
        </source>
    </evidence>
    <sequence length="1303" mass="148670" checksum="26AB9B8A5CB335A1" modified="2020-12-02" version="1">SAVCGVILLYVLGLLWIKRIRSKEQVHIGATIIPHRSFYRHPHHYFLLFYTGSGRHAGTTANVYCVIHGKQKKTKPIVLRDPERLLFQSGTTTSFLLTLNKSLDQITKLHLWHDIXGPKPSWFLEKVVVCHLNTGLLWHFEAHRWLDVSEDDGSVECVFIRGPEVSVTMVTVLVVTVAVDSKKDGDVFPSTKIILGPMAFKLSDIIWGVICSVIPFFLRLLLELLFTYSESKFRQLPPDERDVKAHIDWCLNKANEITFLDGQSNTFDGEKENNDELENAKEENEAQIKENESELSHRMRXXSLQSESEWXYLAESWSEVSLRNIGXDLTDHDCGSENQNENERXETDLHXVTNPDSTLDGNSDTTINKGTXIENQGEVKENIXPSMPNEDGSPIIQQAENELSTTXDTEYENXDDIHLIKEXDFLAIPSDTCQTTAESNAQSPENVXQKNSXEXXTXNGECVKXVXGXSECSFEDGRMSTSSKKMENDXNDGXITDQVNFAYTNSLRNTDKVPKLWKMIPLPGFLIDPNSIKIRNEENTLKLSIXFFYLALFVCLALSLASSXVTIKSGLSXSSQTTVSWLMTVIFALVFQISIAESFYVFFQAIYFGVYLQRPXEENDVINEQKNKVWAKEEDDVRYYVDDLDDXXSSVPMPPSAQEVKKARKKAGQDRQLEEVLMMVAFDVIFLLQLVIISFGNRDAYSYPSRIVVETNYNISNYTSIQNANNFWGWIKTHLVTGLYYEGNFKQAGSRQTRDGYGTLLGVPILRQQRVKPNGTCTLNEYSSPYFPQCNVPVPSVEHYDEKDYSPGWKYEAARDXITQSPWIHKKGSQSNTDYTMYARINSYEAGGYIASLGYNKSSALKMLNELQQLNWIDRFTRVVFIEFASYNGNINILSDVAFAVEFTAFGGAFPRFDHFSFRLYRYFTPLQLIYLVCEVIFIVFIVQLIYKVSCEIYEYRLAYFASFWNMTDVVLVVASLVTIGLYGARAIQLQNGIKAIQENPTLFYGFYPIALYDNLVAFISCIVVIVPTLQFLKFMKFNKNFMIFDLTLKILIPDLKGFVLIFMISLLGFSFWAFHMLGTEQEPYSTFIGAFNSILSMLLGKFSFRVFAPGESQDFGPLFTYAFTLVNVFVIMTIILCIITIAFTKARQDKSIKNKYEIVKFIVYRVKDILGLNPPYIPPKPVIKPTPVDFSQLQLELNTQYIMESQMSRIQRFANVVYSEETIDDVEIVERILGLDNGAEYLKTIIRKRKEEQQVLMEGHHPTIVPHEDQGSEEPKETANHGQDRRLSTLSIENECSQDFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I608</accession>
    <name>A0A6P8I608_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA (Cytosine(72)-C(5))-methyltransferase NSUN6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560427.1">
        <property type="nucleotide sequence ID" value="XM_031704567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I608"/>
    <dbReference type="FunCoup" id="A0A6P8I608">
        <property type="interactions" value="1611"/>
    </dbReference>
    <dbReference type="GeneID" id="116296537"/>
    <dbReference type="KEGG" id="aten:116296537"/>
    <dbReference type="InParanoid" id="A0A6P8I608"/>
    <dbReference type="OrthoDB" id="260824at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21150">
        <property type="entry name" value="PUA_NSun6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF34">
        <property type="entry name" value="TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560427.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="51741" checksum="9E6113FF005190FA" modified="2020-12-02" version="1">MSCFTKLEFSSPEVEDFLRNSFKSIEDEDHKESLTSKTNHEEDSWFDLLLKCLTIPPLFTTVRVNTCKISVEDAKKQLEKFLYMQYKSKGQDCPVVRPHHSLPDVLVIPGTGPHDMTPSRKEIIVDTICGTAVLRGADVFAPGVMGAHPGIQKGDEVSVYADLDNGCRKGFAKPYEGRKMFVGNGTALMSRSDIFCDNSNISGVAIQMNNALYDCPSLSGVLPGLVFPQNLPSVVTGHVLGPQPGETILDMCAAPGGKTTHLATLMDNKGVVIAFDKNSPKVQKIKSNCDAMHLKNVHAFHFDAIKSLDPTLQSRQINPEDVGHPPYPPQSFDRILLDAPCSGLGQRPMSIVRMSLKDLQSFPRLQKKIFPAAVGLLKEGGVLVYSTCTITSQENEELVAWVLTNFPCMHLCPQNPFLGSPGLAHCGLTDEERRLVQRFDPTTTHSTPPREPCDVDTIGFFIAKFVKKTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I848</accession>
    <name>A0A6P8I848_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116299655</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031564213.1">
        <property type="nucleotide sequence ID" value="XM_031708353.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299655"/>
    <dbReference type="InParanoid" id="A0A6P8I848"/>
    <dbReference type="OrthoDB" id="6021362at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000080">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="290"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="661"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="889"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="1061"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="1175"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="1361"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="17">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031564213.1"/>
        </source>
    </evidence>
    <sequence length="1457" mass="164818" checksum="5657CEBB3A63C5BF" modified="2020-12-02" version="1">MQNSVIAADKITASSGTAGDQARLNYTNGPSWCAIGNDDNPYLQIDLGTPHIICAVSTQGDHLAKQWVKTFQLNCSDDGKTYHPYKENGNTQQTFYGNVDNSGIFKQILYQGIIARYLRILPIMQHGAVCMRAEIYGIRIQSTSKVNYAYDKTATQSSTGWDAPPDRAVDGNRNPNFDSVKSCTHTEMQDNEPWWMVDLGQSIPVYEVFIVNRKNHHERLHDFLILIGGSSSNGGKSNPVCNSVKGPLPSGIGTSIYCHQSMMGRFLTITFDNHVGILTLCEVEVYTEVYMELAIGISNSSAVPDNRMSASSNYSNTRTAAKARLLGNYSWRPRDDDTNPWLQIDLGEIYYVCAVATQGDPDGDERTIKYKVEGSIDNLLWMPVESKTLKKEMVFSGNQNKSTSIIKHSLPSPLAARFVRFYPVENIEAYALRVEIYGVTKVSVPPIPPPIGNKELHPSLGSHIDLVCRAEGGLSIKWYHNDTDITSYSIGSVGTGSILISTLRVNYTSVDDVYDKYSCDATKMYCTSLDYICQVDYGSYRKLQSRGKISTLLVPTRPRHLNATINPQRGTQRPTVTLKWEKPMRAIGKTTSYTLCYNYVIDNNSSMKSLTITDLTGMSYTIDVIGGARFEFYLKAKANGLIGDPSQTWTANIQECKPSSAPANIKVIKIENGKYNVSWEETPRELNNSKIITYEINWSSLARRMRRSTVASRAANASESTYTLVNISLTDNMKYNITVRGYTIAGPGPFSDPIVLEKEIEKADGRKEDDQVPDSVIVVAVVFSLLFVVGMIVFIFWYKKRKGQEDTTQQENPGGHLRMRSTGGVAVRPLASHQCDPDEYNQNENQNEGNIEMVEVEGDAIYENKTEKISIRQFPDFMNRVRRNEHELLMHQFKILPQGRLYPCTVAMKPINKSKNRYGNIIPYNNSRVVLEKLEGDEDSDYINASYIWGYDCKQISYIATQGPLPQTVNDFWRMIWQEKMSVIVMLTGIKEQNKIKCEKYWPENSKTYQDLSVHLHKTEVFADYSIRTFVVSKMKTREQRYVFQYHFTAWTDKGVPQHATQLLAFRRRLESDTAMGSPWVVHSSTGVGRTGAFLAIDAMIRQARDYKTIDVFNFVKTMRQNRQNMVQTKEQYLFIHMAILEHLTCRITEVQAQQLGKTIKKLTIYDRKEKITGFEKEFKHLSALCPDVPKDEMKIGSKACNSKKNRFQHILPLDKARVILQADPDKGGNDYINASYANGYRQKDAYILTQAPLDTTIADFWKMIYDNKLGTIVMLNENKEEKMVKGFSLHCLSYPSYWPEKGSLEFGNIPVEIIQKETEKSIVSRVFTLTHKSDGPNKPHKVRHLQHTGWSDGSVPGTTTSVLDLVEKIQRSQQQSENKPVVVLCSDGVGRSGTMCTILSLLDRVKTEQMVDVFQTVKALRISRPGAVDTAIQYQFCFQVVMDYLESFSEYANFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I898</accession>
    <name>A0A6P8I898_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galactosyltransferase-associated protein kinase p58/GTA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116300139</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031564784.1">
        <property type="nucleotide sequence ID" value="XM_031708924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I898"/>
    <dbReference type="GeneID" id="116300139"/>
    <dbReference type="KEGG" id="aten:116300139"/>
    <dbReference type="InParanoid" id="A0A6P8I898"/>
    <dbReference type="OrthoDB" id="647at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000124">
        <property type="entry name" value="cyclin-dependent kinase 11B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="565"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="873"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="380"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031564784.1"/>
        </source>
    </evidence>
    <sequence length="937" mass="107279" checksum="4201C66FAE89E3CB" modified="2020-12-02" version="1">MSGNTAKWSRKRSSNEEDYDNSSIKEDEKLPKAGDWKVKTLDEIRQEKRRKLDNEYFEVETEGSRLSGKSSSTSSPSLKIESRSSSKRPSPLTPQEIIYQLSPDHSSPLSTESDGSSKKRPMQQKGRRKTAEEEEGEILSDISDVESGTSKQRSRGNSRRTSVDVEMVEKPTAEEEEEEESEEESSDEDSESSEEEVEEETKVEKDISGSTQDKQEETESSEEEESSDTDSDDSEESSEDEEEEDEKNNQTSENKKEETKVENQEDSDDDSEKDSSESDDSDDSDSSEEEEEESPAKDVKQKQNIKTNKDENGEDVNMKSSRTTDSRKEQEKDRKQRDGLEQQSKSRDKYDRHTEEPSKSSSRRRKNYDEVQGQRHSREKPKYSKDSSDDLLSKENKSREKSEEQSKGEKVSSKREKNSRPIKDRNEMIESNRSKGEDRDSYKRKRREGKSSSSKDENRSSKRDSGSKTSNASESRLREASSERKTPREQTVSKILMDQERLQFSTEVVDSESDNPSSDEDSSDSEREKSELNESQENEKEDERPRKLPDYLPGIQGCRNVSEEFVWLNRIEEGTYGVVYRARDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGNNMDRIYIVMDYVEHDLKTLMEHMSSKFSVGEVKSLLVQLLRAVAHLHDNWILHRDLKSSNLLLSNEGILKVGDFGLAREYGSPLRHYTPIVVTLWYRAPELLLGIKEYSCPIDLWSCGCIFAELLTMKPLFPGKSEIDQINRIFKELGTPSDSIWPGPPKYSELPHVKKMTFTEYPYNQLRNNFGTYLTDKGFDLLNRFLTYDPSRRITAEEALKHEYFNESPLPVDPDMFPTWPAKSEMMQRPRRKDYQHSPKPPEGGEMFSKLKDGSDSSSATAAGGGLQGFHMPSSKKGSAAVAGFALKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8M5</accession>
    <name>A0A6P8I8M5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AT-rich interactive domain-containing protein 4A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116297025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561010.1">
        <property type="nucleotide sequence ID" value="XM_031705150.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I8M5">
        <property type="interactions" value="3552"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116297025"/>
    <dbReference type="InParanoid" id="A0A6P8I8M5"/>
    <dbReference type="OrthoDB" id="5986491at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20389">
        <property type="entry name" value="Tudor_ARID4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20390">
        <property type="entry name" value="Tudor_ARID4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012603">
        <property type="entry name" value="ARID4A/B_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
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        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF01388">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08169">
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    <dbReference type="Pfam" id="PF11717">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54160">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="315"/>
            <end position="407"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031561010.1"/>
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    <sequence length="1217" mass="134664" checksum="27586B503582BA17" modified="2020-12-02" version="1">MAQGSEEPPFLKVGTEVSAKYRGAFCEASIKIVKKHVKCKIQYKDNTTATLTDDVVKGDLKVGSNVEVKTPDGKIMNGVIIKLTDASTYTVVFDDGDERTLRRSSLCLKGERHFNESETLDHLPLTDPENFGTPVMQNGKKRKKRRPSFQQSSNADDTGSEKEESAPIPSKKKCLFNDSIVGKVVVVERGTRRKSHWFPALGVSPSPENMVYIKSKDQCVVRSFKDGNYHVVNVRDTKEFSKDQDPVSSSLKTDNRANKPAIERAIAYIETGRIPSIWEGNKSEVVTHDDNDDDSRRSSSKPTKAASSDDETDEDAERDAFTEKLQNFMEENGTPIVRHPILGNQDLDLHKLYSLVMEAGGMEEVTKQQQWRNIYSKMGIAIMPPSASHHIKMAYKKYLQSFEVHETSGSTGGSGKDSDEEKSDTSTSKNGRTRLERNSKTSTRQGXIEKVEKTSTDKRARTGSAEKVEEKASTPNKPALNKPRRSSTPNKPVSKPVSKPVSKPVSKPVSKPVSKPVAKLAEPVSTSNKPSTKLPVPIKWPLSNLSTTTPNKQATTPTGKTSAKSTLSKRSITNKPSTPETIKEKPEDNVKIEIKVENENGEVAKPEVKTEEQENGQKNLKRQDSIESDIDVDEQVTSPESELAVDVVNSPGSMSDTSESKSDTRSDAGTEEFIDCXVGDKIQVKYGRGRNRRLYEAKIITVDPDAEEGLLYLIHYAGWNIRYDEWISPDRIHCKSNKLSKKKGGTAKEIPRSKIPPRPLGKQYIRSLSKRGTKSPPPSSSSNKASDSKTNQGNGSKNSPRNSPSPPQIDSSLSSPASSLSTTNSSKSVAKASTPSRRTRSERSSLSNGLEEAVKSPPGRRRQKXETLEPPTEKQNLEKTNETPLAGPSDKGSTDSTESFKESSESHIKNENEIKLESKDQDCLGSSPSNKLDSINFENSNEQDSLNFPTNKTWAKLPNGLTNYSSSSESDCPEHSTSDNDMEPASKKIKLEXEKELGAENIQRLLDEHVEHKSPVVAPYSKGSSSSENQNGSECTREEREKEQKDSDGKEKDDLSETKSSSGPESSKETTSLNVSKEETKSEKKDDHRNKRHRKKKEKKKHRRHSVNENSSDVPGSPNVAHSPSSKGSPTRPKICFDSDLETIKSMEDGSERIRLLQLKINEMRKVYGSLKAEVASIDRKRKKLKKKREDAASHESNSKSSHSNHVTSSPAPVECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I998</accession>
    <name>A0A6P8I998_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116299314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563811.1">
        <property type="nucleotide sequence ID" value="XM_031707951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I998"/>
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    </dbReference>
    <dbReference type="GeneID" id="116299314"/>
    <dbReference type="KEGG" id="aten:116299314"/>
    <dbReference type="InParanoid" id="A0A6P8I998"/>
    <dbReference type="OrthoDB" id="5974593at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00233">
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="231"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="585"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="26"/>
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            <begin position="492"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005864"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031563811.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="73064" checksum="B56F6FD94B14991E" modified="2020-12-02" version="1">MESDPNELLSALRDAEEFISVGLSKESLNRETENKRQKLETRLKNLINRSTPRSDGQLPPRPPKSVQNATWEEEEEGEDLYDDVGPDIIEVKEESDDRVISQSHFSMEVRGVPKETQDNDTQESYEDMSNKEVPQEEMYDDTVNTPSEDDYEEPGKEDSTSITEDIDYEVAEPKHTPEEEKSDDVYEGVDAGDGQEETNKADAESLEQKDRTITRDLEMLMNPIKATDVKEVIYKGYLDKHRKKGKLYIGNKWQKRYCIVRSFAMYYFINPNSDRQKGTILLPGYKVKVNKQSKSNREFILTREKDRSYTVSIHRFQSESKEEMVKWMDAIEKAAGGKISKRQSEYLDSLRSESPDGDEDSTSLCYDDVSLKSGTMNNGQSGGGEIYDDVNENDDSGSATIDYEIPQAEASEAAMEESTKEEAVQEDFYEMPKDENQERSAPVQPSRPAVVVQAASSVPGKPPSHDIPPTTEEEEELYDDVGVDVSPPDVAQTLTKPQMSLPTPPSDIGRASPGMPRPALPPPPGEPKPSIPPRRNGALPPEPDKETTAPIGKAPPPPPPEENTIPDKAPPPPPPEEETEDQAIDYSNIYQALWDCNPDADDELEFSRGDLIYIYEKPHSDWWIGSKYKPQGYETRLIPRNYLTEAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9S8</accession>
    <name>A0A6P8I9S8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116299391</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563941.1">
        <property type="nucleotide sequence ID" value="XM_031708081.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299391"/>
    <dbReference type="KEGG" id="aten:116299391"/>
    <dbReference type="InParanoid" id="A0A6P8I9S8"/>
    <dbReference type="OrthoDB" id="5956799at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1604"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="15">
        <location>
            <begin position="634"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="16">
        <location>
            <begin position="787"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1194"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1242"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1364"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1246"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031563941.1"/>
        </source>
    </evidence>
    <sequence length="1679" mass="185140" checksum="F6B1D988692F3832" modified="2020-12-02" version="1">PTTADQTTQAPTTSAPTTGAPTTLAATTADATTQVPTTDDPTTEAPTTSAPTTQAPTTSAPTTAAPTTAAPTTKVPTTVESTTQAPTTAAPSTGAPTTLAPTTGDATTQAPTTADQTTQVPTTAAXTTAALTTSDATTQAPTXDAPTTQDPTTADPTTSAPTTSAPITLAPTTADATTQVPTTADPTTQAPTTSAATTQAPTTSAPTTADPTTAAPTTQAPTTADATTQVPTTAAPSTGAPSTLAPTTADATTQVPTTAAPSTVAPTTADATTAAPTTSAPTTQVPATADPTTAAPTTQAPTTPALTTQVPTTTDSSTAALTTLAPTTAAPTTRIPTTAAPTTQETITLRPSTTAPSEDPLMYPYGLEASDTKYNWKQWYWRCPRVDFDFGGLPFFGRKHYHIHVCPNGLMSFDSSWYRRWPYNFGQYYWFDRYAMLAPYWGLTDVYDSFANDISQMYYHVYREYDGNPSTESILKRAAVDVNKHTRNNPLPTEFTKATYVLVVTWVSLRHWYSGRRKVMQNKFNTFQAVLITDGVFSFVLYNYPQNGIQWSAPDETRYYYRYWYDRALPVVGINAGDINRNYYNHPRSGRVPIVDIDQIEGLNAIKSFGDLNFRQTLNGIRGRLFIRLEDSPGRLDAMIECAKWYVKDNWELXSRGLQXYLNTLEACPCTYWQAWRDRRFRYESGRWPVYCFVSRFPSVFGWGQKCCYEFIRTTGWWWGWWWWFPLLTSGFPNGGNAQRHHQHWDRYNWVQNDYKAYQQCCVYSNLCWMYQERRPSDTCARYVPPRMTWFWGDPHFVTLDSKNYTFNGLGEYVMLDAKDGYFQIQARTRLAKGKGTATVFSGAVAKENNSTTVQVTLPYDNETMEVLVDGKPFDFKSLTNESIDLNNGSVTVSKPEKQCFEMTFPSGMSVTICEKQNILSIVTAAPESFKNKTKGLLGTWNGNPEDDFTLPNGTVLPHDMNGSDIHYKFGLPWQVNSTTSLFTYKPGENFSTFVNSSFKPMFIEDINWANDSLRLQAEAACNGDISCLFDIASTGDLSVGLSTRQIGSQFVNDSNRLSNEAPKFSNSSSEIYLNINKTVTVLINATDDDGDDITFNVSGLPDGTNQKIYPTSVSLKWKVTMEKFQLVVIATDSKGASTVFKPTTYICPCHNNGICEKPNKLANQSLADPGKERFFLMSCVCVDGYTGQYCESDIDACEANSNPCYPGVECKDLPPPANLTSGYTCDPCPSGYTGNGANCADVDECAGVNDCEQICGNTPGSYVCDCKKGYKLNVDKKTCDDINECDPVSDCMQNCTNYVGSYSCSCNKYFKVKPDNSKQCIPETPCKNNRLGCTHVCYVADEVDTCACNQGYELANDKRTCEDIDECARNIYRCQQKCHNTKGGYYCSCVDGFELASDNVTCNDIDECMRWEFNCTDPSQLCVNTAGSYKCDCEAGLYWIDNKCRALKKDEPTPTPPPAPTPKTPTVNELENAVIIKLENLTFLQWNKENEDRFKEAVAKAVTKYCANASHDCGARDPNRVTMYTADQVHLVPDFXKENPXHLAFYVNQPPGVGQPGKTTIEKDTLIKIIESHQDDIGKSLNTRVTDVRPYKEPAPGPIETDYLPIIIGSAVGLVVLLLLILFAVWWLYRRRSKVVATEKGDQLTEKEIERIKHFPFEELEMQTEIPRANAENRLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAU8</accession>
    <name>A0A6P8IAU8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Fibropellin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116299773</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564351.1">
        <property type="nucleotide sequence ID" value="XM_031708491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAU8"/>
    <dbReference type="GeneID" id="116299773"/>
    <dbReference type="KEGG" id="aten:116299773"/>
    <dbReference type="InParanoid" id="A0A6P8IAU8"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
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    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027625100" evidence="15">
        <location>
            <begin position="24"/>
            <end position="699"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="228"/>
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    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
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            <begin position="266"/>
            <end position="302"/>
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        <location>
            <begin position="341"/>
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            <begin position="379"/>
            <end position="416"/>
        </location>
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        <location>
            <begin position="450"/>
            <end position="486"/>
        </location>
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        <location>
            <begin position="487"/>
            <end position="523"/>
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        <location>
            <begin position="524"/>
            <end position="560"/>
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        <location>
            <begin position="561"/>
            <end position="597"/>
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    </feature>
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        <location>
            <begin position="598"/>
            <end position="634"/>
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        <location>
            <begin position="24"/>
            <end position="50"/>
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    </feature>
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        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
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        </location>
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    <feature type="disulfide bond" evidence="13">
        <location>
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        <location>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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        <source>
            <dbReference type="RefSeq" id="XP_031564351.1"/>
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    <sequence length="699" mass="77019" checksum="1439425173EF4C74" modified="2020-12-02" version="1">MRLNFLGLFLGILLLFFTQATKSESGDAKNEGNQIFRLQNNGTKEQPKQKWMKSKYHKVEFLKRVGSKTRKTVPKTMAPSKVKSSTKAIDRLPLTSKGKKEQKRQFILRPPHLSMFGSFQKSPFMMMRPPPLTQKTVVTTHIPRPPIAIPYNSLLMNHLFHPFMGEQHEMRSPLQMFENPNLMKQFEEDEDEDSNCDSNPCQNGGTCNEVKNGYECICTHGFKGSDCEEENKCHPNPCRNGGICTMANGGYVCTCMQGYKGTNCEEHNKCQPNPCRNGGSCTEVDDGFECACPPEYKGPSCEVQNHCYISPCLNGGTCLSSSLSSFSCLCGDGFSGQSCEVESKCRNQPCRNGGTCFDHHNSYTCACTNGFSGVNCDTMISACDSNPCLNSGSCINQGPNIYRCICQHGFKGKNCESKFIRYEIILRKPAQNGQVCLVHVSRIICLFSEQINLCESSPCANGATCSMFANTFHCLCSDGYKGLYCREVEKCHPNPCRNGGTCISELNSYRCVCREGYRGNDCEEELKCHSNPCQNGGTCYENSGGFTCTCMEGYKGVNCEERDRCHPNPCRHGGLCEVENNEAVCSCSSGWTGLTCEEEDRCHPNPCEHGGVCITKAFRYDCHCPIHWSGLNCEVPSATFAAPLRETASVVNACATTTYGCCPDGTTAAVGPHQAGCPEHIPGIGKRTVIEKAEKRSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBJ1</accession>
    <name>A0A6P8IBJ1_ACTTE</name>
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        <submittedName>
            <fullName evidence="4">Tctex1 domain-containing protein 1-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298507</name>
    </gene>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:dynein intermediate chain binding"/>
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        <property type="term" value="P:microtubule-based movement"/>
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        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562867.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27523" checksum="CF77318FCBFEDF41" modified="2020-12-02" version="1">MKKDRSMSEKSNFTKPLSAALGKATGVFTRPKLQRRAFTAHAASELISAASLSSVLLDLRENGTKSQDKIQTEQEKPEVIDDAPNVLISHRLSTCHGNGTGIVDSKTKTEGNVHEPRRNSDTAVSNNPQLQNNKFIAKDKDFTSLNCFRVKNIISETLKAHVGNMEYDHQECGEKSRVMSQIIEKRVKTLSNAQYKVTVMVFIGAIRDKGIELATQCVWSPAEDYFAMATHKNETVFASAIVFATIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEB3</accession>
    <name>A0A6P8IEB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase TRIM71-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565072.1">
        <property type="nucleotide sequence ID" value="XM_031709212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEB3"/>
    <dbReference type="GeneID" id="116300355"/>
    <dbReference type="KEGG" id="aten:116300355"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF57">
        <property type="entry name" value="BEE-MILK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="Filamin" evidence="5">
        <location>
            <begin position="55"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="307"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565072.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44840" checksum="E0BCDDEF4F560C94" modified="2020-12-02" version="1">MQSLLDIGRIVKNVTDPARSTIESVKKGPRGFINECKIITRNTEGEVCPTRIESIDVRIKDVEGNEVEKKMSEEQTGKYRVSFKPQKSGRHEIQVNIGREKIKNSPQNVEILDVKELFKPVKTFGGRGSGRGQLNYSYSIAVSDNGEIAIADCRNHRIPIFSLDGNYLREFGRKGTGEGQLYYPFGVVFNENRIIVSDGPHGKGRLQEFDLNDTYVRTNYRHDQWFVPRGMCVNDDKNIAVCCWGKQELGIKPSIKVLSKQGDLVHEFDMPDKTEHPRYITYGNGKYFVSCLDINYVIVFDVNGVFLYKFGEEGERDGQFNGVGGLAVYGPEMILVCDRYNNRVQRFTQEGQFIRSFGSRGSGVGQMYGPVDVVVTADCRVFVLEWLSNRVTVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEB5</accession>
    <name>A0A6P8IEB5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 9-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116300364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565082.1">
        <property type="nucleotide sequence ID" value="XM_031709222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEB5"/>
    <dbReference type="FunCoup" id="A0A6P8IEB5">
        <property type="interactions" value="1838"/>
    </dbReference>
    <dbReference type="GeneID" id="116300364"/>
    <dbReference type="KEGG" id="aten:116300364"/>
    <dbReference type="InParanoid" id="A0A6P8IEB5"/>
    <dbReference type="OrthoDB" id="10059035at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008853">
        <property type="entry name" value="TMEM9/TMEM9B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05434">
        <property type="entry name" value="Tmemb_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028146174" description="Transmembrane protein 9-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031565082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19659" checksum="3B846547C041FD3A" modified="2020-12-02" version="1">MRWMLMLVVVFLHINTIQSESSSSQASYSDVRCKCVCPKGNSTERNVFVATVEPEQCNCQHIVKREENFCLRCQCMYEARNTILIKVVIIFIIVLLVCLTVYAIYLLVDSKMSPVEISVSSDEMQERLTARTRGARNFSVRAFDRRHARWKQQVAAQRRHIYDTRTMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFH8</accession>
    <name>A0A6P8IFH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U11/U12 small nuclear ribonucleoprotein 25 kDa protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565499.1">
        <property type="nucleotide sequence ID" value="XM_031709639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFH8"/>
    <dbReference type="FunCoup" id="A0A6P8IFH8">
        <property type="interactions" value="1277"/>
    </dbReference>
    <dbReference type="GeneID" id="116300723"/>
    <dbReference type="KEGG" id="aten:116300723"/>
    <dbReference type="InParanoid" id="A0A6P8IFH8"/>
    <dbReference type="OrthoDB" id="72819at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17058">
        <property type="entry name" value="Ubl_SNRNP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040610">
        <property type="entry name" value="SNRNP25_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18036">
        <property type="entry name" value="Ubiquitin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNRNP25 ubiquitin-like" evidence="1">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565499.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17375" checksum="257962AD8BC38D0B" modified="2020-12-02" version="1">MADEEEEMEAMSHPELMALFRKELNKLMQDPLLADLPSEPTVEEVNAQLALEHGRAIVVNVRQMDDVGTILPVVVVQNATVDDLKKAIKRHITLKQEREGGTITNINWKHVWKTYLLTYDGQKLTEDHKPLKEYGITSKDVVTFTKRLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFZ5</accession>
    <name>A0A6P8IFZ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pantetheinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565657.1">
        <property type="nucleotide sequence ID" value="XM_031709797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFZ5"/>
    <dbReference type="GeneID" id="116300841"/>
    <dbReference type="KEGG" id="aten:116300841"/>
    <dbReference type="InParanoid" id="A0A6P8IFZ5"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07567">
        <property type="entry name" value="biotinidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012101">
        <property type="entry name" value="Biotinidase-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027709404" evidence="5">
        <location>
            <begin position="18"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565657.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="56928" checksum="AC35B82B874A5691" modified="2020-12-02" version="1">MYLNLLAVFLLVHSCVALNHSNSKDYVAAVYEHAAFFIPGIKTPPRELALKIMMINLAVYEEQAKKAKSRGAQIIVFPEDGLYGYGYKRDDIKSFLEIIPKASSLKHPWNPCLDPSRFSNTEVLNKLSCIAMNNTIAVVANMGDLQPCSKPRDPNCPDDNHYQYNTDVVFDLDGTFLAKYHKQHLFHENQFNTPSQCEYVTFTTGFGVRFGVFTCFDMLFKCPAVDLVEKYGIRNIVFPTAWFDGFPILMSVEYQQSWSRTNCVNLLAANIHIPLDTVDFFGSGIYSCGEIKAYVFDPLATKEQRLLIATLPDLEATTKDASDPPNPGALMPQAEVKQALENVNKEASDDGGRMAPVFEGEIMDDNYMMKWLDPHNTRISVCHNALCCTLDYSIGNNKVEESYALGAFRGHHNPEGFFLEVCILLKCAGSSEKMCGTKVDTSSTVFKYVQLSGNFTSTAHVYPEILTSGLKLAAKQEVSVSGHVTMTTKTLREPLISASLFGRDYDKDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG99</accession>
    <name>A0A6P8IG99_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hamartin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565731.1">
        <property type="nucleotide sequence ID" value="XM_031709871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG99"/>
    <dbReference type="GeneID" id="116300902"/>
    <dbReference type="KEGG" id="aten:116300902"/>
    <dbReference type="InParanoid" id="A0A6P8IG99"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565731.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23779" checksum="F8F3DE171FE8E084" modified="2020-12-02" version="1">MYDKSLHKGNTNFYLLQKLHQCESKIFTLQNEIDCMKPKLAEKSQLKSEIERLIKELVIMGELNQHHKDMMEKAAVDKGKKPEASLQFYACQKELTASKQMVRKQKTEIEALHSKVAELEKHLTKKDVEMKEFRKFSESLNGIYLAKHKALEEKYTAQKKINQTLEARILNLQLALEDTKHENTMQAAAKTKTRATSPIQEETSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGD9</accession>
    <name>A0A6P8IGD9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="11">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116300918</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031565748.1">
        <property type="nucleotide sequence ID" value="XM_031709888.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IGD9">
        <property type="interactions" value="2188"/>
    </dbReference>
    <dbReference type="GeneID" id="116300918"/>
    <dbReference type="KEGG" id="aten:116300918"/>
    <dbReference type="InParanoid" id="A0A6P8IGD9"/>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21062">
        <property type="entry name" value="BTHB_HectD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041200">
        <property type="entry name" value="FKBP3_BTHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18410">
        <property type="entry name" value="BTHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="15">
        <location>
            <begin position="1316"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="2028"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="2338"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="645"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1335"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1585"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2221"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1355"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1402"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1589"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1627"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="2490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031565748.1"/>
        </source>
    </evidence>
    <sequence length="2521" mass="280242" checksum="BDE440F0A86873E9" modified="2020-12-02" version="1">MVDVDPDTLLEWLNMGQGDERDMQLIALEQLCMLLLMSDNIDRCFESCPPRTFLPALCRVFLDECAPENVLEVTARAITYYLDVSAECTRRIVAVEGAVKALCNRLVVVELSSRTSKDLGEQCVKVLELICTREAGAVFEAGGLQCAITFIREFGNSVHKDTLHSAMNVVSRLCGKMEPQDPNLEACVKSLSTLLKHEDSYVSDGALRCFASLADRFTRRGTDPAPLALHGLTKELLERLANAAGPNLDKSGSAGATPDSKSNSTSVSTIVSLLSTLCRGSPVITHDLLRSELPEAIEKALQGDERCILDTMRLVDLLLVLLFEGRQALPKSCVSIPRAGGGGIRRFDSSSERSHRQLIDCIRSKDTDALIDAIENGGFEVNFMDDVGQTLLNWASAFGTLEMVEYLCERGADVNRGQRSSSLHYAACFGRPAVAKTLLRHGANPDLRDEDGKTPMDKARERNDEGHREVVHILQSPGEWMVPVASGSTAEGQAEEETTAEDGPSDENKGKEKEKEKEKEKEKEKEEDTKGDPEMAPVYLKTLLPVLAKNYLSTMMPSIRKATLALIRKNIHYATKELLLDLSQIPNVASLIVEVLAMVLDHEEDDDGHLIALQMIQDICEKCPDEFISHFARLGIINHVSERAGLNDGVQEEEEEQQKTKLDKEDEPVQEDASELEQGKPYHWNDWCIVRSRDCLYLWNESCAIELSNGSNGWFRFILDCKLATMYSSGSPEGGSDSSESRGEFLEKLQRARSQVKLGMPSQPILSSPGPARLSIGNWFLNCSKEKQMAINNSDGQQATILREDLAGFVFESNRGTKHTFSAETSLGQEFVAGWSGKRGKRFVSKVEAQKQKVKNLATEIQDKYLQSSHATPREVVTRLHEIVEHLNDAALSQENKAFNESGEAKWKDLMCSSLQELLQLFKEDNTVSSYELQTTGLVTALLNCLNVADQTIGHKAKLVRERAEVFKQAFGETEEHLSKESVTDITPASILVKKLVAVLESAEKLPVYTYDCPGSGLQVLTKRLRFHLERAPGEASLIDRSGRTLKMEPLTTVGALERYLLKMVAKQWXDYDRSTFNFIRRIKGGQKVTLTQTGDFDENGIIYWIGTNGKTVPDWTNPASVGLVVVSSSEGKSLPYGKMEDILSRESAALNCHTNDDKNSWFSVDLGLWVRPSCYTLRHARGYGRSALRNWLFQASKDGKNWITLYTHTXDSALNEPGSTASWPIEPPEDEEGWRHFRLQQAGKNASGQTHYLSLSGLEIYGTVVGAVDEALVTEHQQSKTLQDSQSRSLKPCWSLYPGKSRDMDSSPRRQRRLVRSQMLRNLRVGSKVVRGRDWKWKDQDGPSPAEGLVTEGSSSSTSQATSTLVVMQDRPNTVDPACLSDSGSSRDVSPRSESGAANMAAQQEEVSSTTPVVLEGSESEAVSAVMEEIFGGPGTPDDGVSLELDREVPIDSPTPQAGFDSEYDKILLPSSPGNLMMSDEAEFSVVTADDPMTQVMEPATSTXSTRSVENSISNLSVAVNSAKSLLSMARSTASHTPTVTLRHLSDIESLLSMVQSSATAQTGGISRASDIEAEVYEAVRSSGLLADLDDGDDLHEPDDEDEEDDDDDDENDEENEDDYEDMAEEPERPGTRRRMWDDEYVLKRQFSALVPAFDPRPGRTNVQQTQDIEVPQPGTKEESKAEEIAPQQPKLMLTIRGPSSLGPSEIEIPLSNPSATIFSYVQRVALSLGGTKTERIRRVWEPTYIITYREDQKGEQNLQEKEKVIKEHVTPVQWTATYVEQYLGSDELPKSEVVAFLQQHADAAFLRRWKLTGTPKSTRKNRNCSQLVAAYKEFLKNLESTPTSSVSSPMHTRYDRMVSGGSSLTSYKDDLGSVSDILQLLRQLNXLSTSSTQHFGEDDENKFGFMVGPEDFISNKLTTKLMQQIMDPLIXSSNAIPDWCEYLTSTFPMLFAFETRQLYFSCSAFGCSRAIVWLQNQRETAVERTRVPTFRRDDSHEFKIGRLKHERVRVPRGEKFFDCAVAVLRHHASRKAILEIEFEGEEGTGLGPSLEFYALLAAELQKKSLGMWVCDDDAQEGSIKEVDIGHGGRPKGYYVQQPGGLFPAXLPQDAPDTERVVSLFSLLGIFLAKCIQDNRLVDIPLSLXFLRLLCSGGSVSQDQLGLTSLGTCPNTINLGESICSQGWGGGSSDITNELDQPSLEENQNAINKLDSHFSKEDELIKDEELLKEEESELKKTKESVEDVSVLAQEPCWFAGLIDNELSTIDPLRVKFINSLKEVVNRRKEILQDDSLSNSEKKAKVQNLKLNTNGVECHLEDLGXTFQFLPSSKVYGFDALNLIPHGEEVLLTLDNAEAYIELMTDMCLYSGIRKQMDAFKAGFNLVFSMEKLRIFSPEELQLMMSGEHVPEWTREDILNYTEPKYGFTRESPGYLRFVNVLENMNGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVKKEGEGDGSFPSVNTCVHYLKLPDYTSEEILREKLLAATKEKGFHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHK3</accession>
    <name>A0A6P8IHK3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sperm flagellar protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566199.1">
        <property type="nucleotide sequence ID" value="XM_031710339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHK3"/>
    <dbReference type="GeneID" id="116301302"/>
    <dbReference type="KEGG" id="aten:116301302"/>
    <dbReference type="InParanoid" id="A0A6P8IHK3"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052634">
        <property type="entry name" value="Sperm_flagellar-bone_growth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919">
        <property type="entry name" value="KPL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919:SF0">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566199.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34429" checksum="FDAA4ABBE6BEA9DE" modified="2020-12-02" version="1">MTEILCRWLNEEVGLSRQIDHFNFAKEFATGYLLGELLEKHALQNDFAEFSQSITADSKLNNFTRLEPTLKLLEVPYDTNIAHAVMNENHSVVTRLLYQLFITLGKKNKMGLTGVAMETMRPSGPVKLESIESGMYKERLKQLTKRQVDLNFENLVQRYQAKQKQQEELAFKAKFEEEEKFRKHQQAQRIRGLEKSRQVRNKQQEMMDKIREATVKIPKPPDAKKSGKSRGEIRRQREAEEVKANIDAFEASMKATIPPVSPAALDDIPRVSRDVSVDVEVFIRQDSAKQLPDPLSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ56</accession>
    <name>A0A6P8IJ56_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116301579</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566518.1">
        <property type="nucleotide sequence ID" value="XM_031710658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJ56"/>
    <dbReference type="FunCoup" id="A0A6P8IJ56">
        <property type="interactions" value="2278"/>
    </dbReference>
    <dbReference type="GeneID" id="116301579"/>
    <dbReference type="KEGG" id="aten:116301579"/>
    <dbReference type="InParanoid" id="A0A6P8IJ56"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 15" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031566518.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14745" checksum="DBDE97F7B5BF9F04" modified="2020-12-02" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKTKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGVIEPSLRILAQKYNCEKMICRKCYARLHPRATNCRKKKCGHSNNLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ79</accession>
    <name>A0A6P8IJ79_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116301599</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566543.1">
        <property type="nucleotide sequence ID" value="XM_031710683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJ79"/>
    <dbReference type="GeneID" id="116301599"/>
    <dbReference type="KEGG" id="aten:116301599"/>
    <dbReference type="InParanoid" id="A0A6P8IJ79"/>
    <dbReference type="OrthoDB" id="5964333at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566543.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43044" checksum="8AB0BE6B8E77672B" modified="2020-12-02" version="1">MKFADVVQLNIFKLVPLECLKQSIRLTPYAGLVVYISLDAMVILIAILYFFIQKALTNINRDNKRLSKCKANCYRAVFLFIFVTYPATCEKVFQVLPSSCHKVCDNEQGCSWYLQSDYSSKCFTSFYNKFVILVYFTLLIPIGFPVATTFFLWKYCRNNGPEESDIEDEGSDKVHLEVMKKRCQDDAAGHEISAGMRFLYENYSEDCWYWEVIELVRKVIFTSVLVYSGQEGRLFLGVTAILFGFYAVYFAHTQPIPHLFDKWLHLGALMATMANQFIAMLLKIPAETVSTLVDAESDAIGITVMLMFANLFVVIVIVVRYVYGVYFTMQAIRENPKCDLSCVLSVLQVVNFGQGHELSTKKGKKTGREDKIEPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJI4</accession>
    <name>A0A6P8IJI4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566618.1">
        <property type="nucleotide sequence ID" value="XM_031710758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJI4"/>
    <dbReference type="GeneID" id="116301668"/>
    <dbReference type="KEGG" id="aten:116301668"/>
    <dbReference type="InParanoid" id="A0A6P8IJI4"/>
    <dbReference type="OrthoDB" id="10328813at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028185224" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566618.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12363" checksum="42D2B65B2C7E5C35" modified="2020-12-02" version="1">MEKILFLLLLVGLVVAKPSFDGDDDELIQTLINQKDVEDVQYQPEANLNLNDEDSDQDLSIFFKFIHYLIHVSVGKVKPDEHPDIKYIKPGKELVKRLLVVREAVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL05</accession>
    <name>A0A6P8IL05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microfibril-associated glycoprotein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567641.1">
        <property type="nucleotide sequence ID" value="XM_031711781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302481"/>
    <dbReference type="KEGG" id="aten:116302481"/>
    <dbReference type="InParanoid" id="A0A6P8IL05"/>
    <dbReference type="OrthoDB" id="5946302at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567641.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39824" checksum="408D95A6E233BC14" modified="2020-12-02" version="1">MISRAIEKGLFSAVVFIFLLFFRMSLQLDGNGYSTFPQLITKDLGSRYFSVKKGYRLDGKPSKTIQVHDTFTCLQHCMKDSCISVNFQEKTRTKGTHVCELITGKLSPSELDKALRGDDTFNFISLQPPLYKDCHEIYKDGGKVSGVYSISPSQFHPVQVYCDMVTSGGGWTVIQKRIDGSVDFYRDWADYXWGFGNKLGEYWLGLDNIHRMTSQRRYRLRVDMEDFEGNTRYADYGLFKVADESVNYRLTVGQYTGDAGNALFVHDNMTFSTKDRDNDKDNLKSCAVAFKGAWWYNNCLNCNPNAYYYQACKNACPEYKGIYWQQWHGAKYSLKRFEMKIKPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILT2</accession>
    <name>A0A6P8ILT2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC116302720</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116302720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567941.1">
        <property type="nucleotide sequence ID" value="XM_031712081.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567942.1">
        <property type="nucleotide sequence ID" value="XM_031712082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302720"/>
    <dbReference type="KEGG" id="aten:116302720"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000462">
        <property type="entry name" value="Glyoxylate reductase (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="39"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="119"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031567941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031567942.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35895" checksum="1B523F85888CC906" modified="2020-12-02" version="1">MATSDLPLALILQPGTLKYVFQEIVNSYSNKLSXVFIKDVTDLHITEDQYSKIQGLALVGRNGQMDINGSFMDLFPNLLIISSIGVGVDHIDVTEARKRGIKIGFTPKVIGDCTADLAFALLLASARDVVKGDMTSKHSNFLLKLDCSWPGVKVSGSTIGIVGFGSIGSTVAKRAKGFDMKILYHTRTIKEDVEKETGAEYCNQLHDLLKQADFVVLCVPLTSETKYLISASELSIMKPSATLINISRGDVVNQDDLVKALQTGQIRGAALDVTSPEPLPRDHPLLTLPNVIITPHIGTFTETTRIKMIKTVMENLIAGIHGKPLLYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN96</accession>
    <name>A0A6P8IN96_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC116303161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC116303161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568516.1">
        <property type="nucleotide sequence ID" value="XM_031712656.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568525.1">
        <property type="nucleotide sequence ID" value="XM_031712665.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568534.1">
        <property type="nucleotide sequence ID" value="XM_031712674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IN96"/>
    <dbReference type="GeneID" id="116303161"/>
    <dbReference type="KEGG" id="aten:116303161"/>
    <dbReference type="OrthoDB" id="6018356at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568534.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38751" checksum="3BB7590D9D998BFB" modified="2020-12-02" version="1">MCDRACELMISCCSVVCKVCCRYMSAKVAFLIQFLVYGIFQGFNVATDAALFVELFKTQRRCSNMTSSPFHCTSFTPGNSSSTLKKLLEDHVDTLEVLEYSMMLVMGVGAAIYIVHMIILIPNLCKNFHDPDIALEVEGKVAPRYYQNITITHCMFMVLESIIHDIPASCLAMEISVHFWGKNDVNCWECSPITEPLPKEQSLSNTKLWLALMITGIGLLALYKGLMPLYFWVGNPFCWSCYFLRFFMVMPAGFIYALLILTPCMGVAALRVIPAVPSLKDEIGGTADTFWSIGLVFWVLIFICFITYFCCKRTIMDLCPCLAWCEEPKSRNKEEKKAGCICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPA6</accession>
    <name>A0A6P8IPA6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">von Willebrand factor A domain-containing protein 7-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">von Willebrand factor A domain-containing protein 7-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116303304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568682.1">
        <property type="nucleotide sequence ID" value="XM_031712822.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568683.1">
        <property type="nucleotide sequence ID" value="XM_031712823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPA6"/>
    <dbReference type="GeneID" id="116303304"/>
    <dbReference type="KEGG" id="aten:116303304"/>
    <dbReference type="OrthoDB" id="5975513at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653215" evidence="5">
        <location>
            <begin position="23"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Hemicentin-1-like von Willebrand factor A" evidence="6">
        <location>
            <begin position="261"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031568682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031568683.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="84639" checksum="07B15858BAA931FE" modified="2020-12-02" version="1">MHLLQISMVLGLAICLVHNVHSMDFDLMNFARDTVMEYSSGTERTVNILQPQLKVVNPPVNPYKRRNKKKSRRRRPVDGHGGVVGAGGGGGGFLSMRKHRRKFRFKRPPSGYTHRRKFRFRRPPSGYRRNRKPQTKLTFITRTKTYRRRSKPSNKFLEAMATIERAVAEAEVARSRIRYSDQKLQDMKKTIKLAVQKRMFQFARHRLGQALFLIKNHNSTPTSRSRRSTQNQASVFMDDLKQTMGPAQFDKFMAVMGDVTLMFAIDTTGSMADEIDTAKRIAVDVINYQRENPVSYILSPFNDPTTGPVTFRETTEGALFVDAINKLKATGGGDCPELTMKGILDALYEGPDPGSPMYVFTDASAKDATPENINEVKIMAKFLGKVVINFFTTALCRGSSVTDSPFMQIAEATSGQMLSLTSATELQNLNGFTGSVLGGSTIINSGCNIFNRKKRAALTASRYSIKIDDSIGNMSICVTTDRPNQGAAISLTDSQGVTITSGKVSMSKVSIYEIASPRVGTWTLVIPPSAGMHNYFVKSNSDQNIDFDYYFLMLIKKPASEVPVTDPLIGENSKVVITLAGNEKTRKNSVVLELITKYGKHIRDLQLTPDSRGVRYTATFTPPSRPFKLKIKGTTKRGNPFERISRSIVEPKHVQLRVLHSANDFTLRRGTSSTVTFHLYNSANVNKRVKINVKDRLGYARINGLKVRTIRRGRWAFFSVLFRTPMSAAIGTCDTAFISVSVNNGAEIVSQPVQLIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPB1</accession>
    <name>A0A6P8IPB1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prenylcysteine oxidase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568208.1">
        <property type="nucleotide sequence ID" value="XM_031712348.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IPB1">
        <property type="interactions" value="1000"/>
    </dbReference>
    <dbReference type="GeneID" id="116302930"/>
    <dbReference type="KEGG" id="aten:116302930"/>
    <dbReference type="InParanoid" id="A0A6P8IPB1"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="8">
        <location>
            <begin position="139"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031568208.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="56304" checksum="1B6C1C706F3BA32C" modified="2020-12-02" version="1">MKLVNLALGISTSFVLFPALILNRKTILCKAEERVSEDSVRVAIVGSGIGGSAAACFTRKLXGDKASIDVFEASSRVGGRLGVMEVAGRMYESGGSIIHEKNKYMKSFVEELGLKKLKSNEADSLIAIYNGTGFDFIGSKFKILNYIKLLWRYGFDLITIDKWINNMLKHFSNIYDLQDKGNAYENVDDLLNAMGGEEFVGLKQKTTRDVLQNLGLKDITINEIVTSVMRVNYGQDVTLNAFAGSVSLAGVGGGLWSVEGGNYRVCELLLTAYKANLYKETKVSKITKISNNNKPSYIITTSQGLNQSYDIVIIAAPLEVQSNYFTCLSCSNWPQASHTNTFWQTVATFVQGEINLTHFGFQSASDVPEGIFTTENPKNYFNSIGLQQPVQDRNSTDTRDKPVRKVFSRQSLTSEQLQELFATRNVTKSVKWLAYPDLKPARHFTSFILDEGVFYINAIEHAASAMEMSCVGAKNAVLLAYKYYNKQQVDKEEEKREEKTKNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPK9</accession>
    <name>A0A6P8IPK9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein artichoke-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568385.1">
        <property type="nucleotide sequence ID" value="XM_031712525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPK9"/>
    <dbReference type="GeneID" id="116303074"/>
    <dbReference type="KEGG" id="aten:116303074"/>
    <dbReference type="InParanoid" id="A0A6P8IPK9"/>
    <dbReference type="OrthoDB" id="5977656at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568385.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28813" checksum="AE639F31EDC79622" modified="2020-12-02" version="1">MTFSDTRIFMKATIEIVKNGTFASRLPNLRLIDLSGNCLSSLASIESGWYGNKAVSHTLILILNDNKIRNITKYSTKGKGMLNSLGLKRNLISFIEEGAFEELHWLEHVDLSNNLIANLEPNTFVGIGKEIFNIMIDVSSNRLTCIKRGVFAQDLYINSLILFNNSIEAIEEGSINSIHLDTLDIRNNMLKDISILPWGSLDDIFYLYLGNNSIQNLTVKMFEGKKNLRILDIGYNELGIIRKDLFTGLKTMLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQQ3</accession>
    <name>A0A6P8IQQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Shematrin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569411.1">
        <property type="nucleotide sequence ID" value="XM_031713551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303926"/>
    <dbReference type="KEGG" id="aten:116303926"/>
    <dbReference type="InParanoid" id="A0A6P8IQQ3"/>
    <dbReference type="OrthoDB" id="10332513at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028296508" evidence="1">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569411.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17790" checksum="42556865CF32B777" modified="2020-12-02" version="1">MKAFLWLLVLIVVVHAETHIEDENFESIXKDSLKGVVQGDDDDDNFGXIGGGGIGGGGIGGGGIGGGVIGGGGDDDDDDNGSGTAPPPQYCVVRYRQCMMFAFTWYAKQVCTNQYYQCVRIMTHPCYRQRSICLSNAGWNYYQRYWCDVRYKQCLAGGQRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQY8</accession>
    <name>A0A6P8IQY8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303886</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569354.1">
        <property type="nucleotide sequence ID" value="XM_031713494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQY8"/>
    <dbReference type="GeneID" id="116303886"/>
    <dbReference type="KEGG" id="aten:116303886"/>
    <dbReference type="InParanoid" id="A0A6P8IQY8"/>
    <dbReference type="OrthoDB" id="10369281at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569354.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24884" checksum="B3745E6F803D867B" modified="2020-12-02" version="1">MTSMFNLRAHSAVCTRRKELDYDVFFPMYQEHKDMKQQGAYSRTPLLSLRTNVEENRLRPHTTTGIVQGLQNTKNFGLLFTPRRISYRVERALKHTENEKGLCLYKGKPRRMVVTERGIVQNIRPSATVNDTSLFSGATSAWQGDDTMSSSSQQTSNSNGTTLTETTESLSLMPGVFQDKNSKPRIFVRLRQLSSQERVMEWLYRSCNHPCKTLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQY9</accession>
    <name>A0A6P8IQY9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heterochromatin protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116304000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569506.1">
        <property type="nucleotide sequence ID" value="XM_031713646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQY9"/>
    <dbReference type="GeneID" id="116304000"/>
    <dbReference type="KEGG" id="aten:116304000"/>
    <dbReference type="InParanoid" id="A0A6P8IQY9"/>
    <dbReference type="OrthoDB" id="340605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031569506.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22268" checksum="929CCEF9D8B25C84" modified="2020-12-02" version="1">MATDIDDDEVFEVKTILKRRMNNGMVEYLVSWKGFGPEDNTWEPEKNLNGCRALLRDYLRSMKPKDFSPKTTRRRTINLPTTNAKENDFFTRIKSPGRKAQPKVLHMKEPPPPSPLGPKTNKTRIFEEEKTSIQEEKQSVTRTITRKQTKVQNSEQPVQINSNGLRTFVFLALFLFFVILLAFFFKPVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQZ5</accession>
    <name>A0A6P8IQZ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569327.1">
        <property type="nucleotide sequence ID" value="XM_031713467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQZ5"/>
    <dbReference type="GeneID" id="116303856"/>
    <dbReference type="KEGG" id="aten:116303856"/>
    <dbReference type="InParanoid" id="A0A6P8IQZ5"/>
    <dbReference type="OrthoDB" id="5980458at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="48"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569327.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24954" checksum="90408CA1DF2A42E1" modified="2020-12-02" version="1">MVKCKQRARDVLYWTGMNADIEQTVKNCGKCADFQKSLPPEPLASKAPPDLPFSEVGTDLFEYDHRTYLLPVDYYSKYIEVDLLQNTTSRSVIEALKSQFKRHGIPTVLRSDCGSQYMSAEFSRFCKEYGIIHKPSSPHFQSSNGEAERAVQTVKQLWKKATDKHLALLDYRTTPLEGLSLSPAQLLMGRRPRNVLPPTSAILRPTSYSSQEVRRYLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IST5</accession>
    <name>A0A6P8IST5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Hippel-Lindau-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VHL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570054.1">
        <property type="nucleotide sequence ID" value="XM_031714194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IST5"/>
    <dbReference type="FunCoup" id="A0A6P8IST5">
        <property type="interactions" value="2647"/>
    </dbReference>
    <dbReference type="GeneID" id="116304457"/>
    <dbReference type="KEGG" id="aten:116304457"/>
    <dbReference type="InParanoid" id="A0A6P8IST5"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05468">
        <property type="entry name" value="pVHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.780:FF:000001">
        <property type="entry name" value="von Hippel-Lindau disease tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024053">
        <property type="entry name" value="VHL_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022772">
        <property type="entry name" value="VHL_tumour_suppress_b/a_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01847">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="2">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570054.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17933" checksum="B4A4DB3A5D01AD03" modified="2020-12-02" version="1">MENNDQDQEEQGMRSLHHHCVSPVRFQNRTGRNVNLIWIDYEGKQGMLVELQKEQDQNLNTYVTHPWLAEDSETKERLLLNFSEVFFPVEPEIVINDFRPRRAQAKRILVKITTPVHRLEKYCKQVILGLVDKENIKHLPLPPIIIKILLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT05</accession>
    <name>A0A6P8IT05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M-phase phosphoprotein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116303894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569363.1">
        <property type="nucleotide sequence ID" value="XM_031713503.1"/>
    </dbReference>
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        <property type="interactions" value="1795"/>
    </dbReference>
    <dbReference type="GeneID" id="116303894"/>
    <dbReference type="KEGG" id="aten:116303894"/>
    <dbReference type="InParanoid" id="A0A6P8IT05"/>
    <dbReference type="OrthoDB" id="6022064at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
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    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
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            <begin position="695"/>
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    </feature>
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            <begin position="940"/>
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            <begin position="144"/>
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    </feature>
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        <location>
            <begin position="1034"/>
            <end position="1048"/>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="1449" mass="161693" checksum="A78AFD09B495F7A2" modified="2020-12-02" version="1">MEEDDELFEVEYFLNTRVKDGKRYYKVRWKGFPPEEDTWEPEENVLECEEVLEAFWRKRRRNANKRQKLRRDRLMSEGEDQDTASTSRENKATAFFGDIEPLGLTRQASKELAMCMIQTRKTKTCSESSSQAGSDVALMESDVSNQSSSKSTLLSSQTGSDITASDNDVFSQSSDVKSSETGDDILNRSTESTNESNSTDVIHISSHESLNQSDLESSPLETLDKNIKSNSGKTNNIEIISLLSDSEDNNSEVTGSRTQSPRVLQSPLDVSSDCSPVIRRESLETPESTPTKFSQSNGAQDTKKAFDTSSEQSPGFIKENDEDQSIFGTPVRRKNRFELSLKKNRKRSLNKKESSSSESPKTEEEALNFGAKIKNHDNSSDDESLVKIKGKTQLQTLKERMLELENSEKILEKSDSEFLEISEPKAKRALIKGDRSNESSMVDNVCPTITELKGIMHKIARDKYQKHIDAEQGEGTEMACIKNRESSDVSCSSSPDLSKAKTSKTMSHSDERRAVEKMLPEDDDVQEKQDGLNLCSSDVSKRLLVEDDEHSTFDGRMASIEDSATACNDEGESNAMISISLSETKDENLKDIEKDEISCMYESPSLEKGDHLQRRPEEEGNNSIGEATLEKGEEEKRETIKEWTSAVEPRSSKKGLVLTSETTSRVLKNLRFLAAKTRESKNVEATMNLATTENTQQATEKNNDGINGKKIESENNLGNTNADNENNKLVLEEKLVGSEKQLNEDENTSEKEIGRIAGVEEGNKSRETDEKKKNEKDELGLIDVRIKPIHKESIRNDNDVKSRVEKIDDKCTEINNSIHETEKMQNIESLTDKEIKPATPERTQVVVPYTEELRRSRYDSLSRAEKNCEMNTKDKTSDDFNLVDVDDMMREDSENCTNSSATIKPKSSSDVQSSFINDTASTHGCLGDHGTEETLVQNFQKHSSVESSAAKEKNKQKNRKPKKMLKKSHENTAAGKRVKRKKPVQSMANNVNSNQGVEKGTASSSSMKLNLQHSKAMKGAKVKKNSKMDKNEESNTTAKAKSNPTLQNTREEQSKKSSILDANFSSSLTSGDLIGAIIGEGNRENILEENQKKSCATENNNSNDLVAAREDEDXMIEDDEDFDFELEDFPLEKLLQEEDDIYVXCIPSPPFEPMEVPFASVKTAIRDGDEMTVRAALAGELELDTLDGASGMTLLMLAAASGQDGVVELLLRRKADLNACQKNGMTALMHACEQGFPETAHVLLLYGADINKQQIAGETALMKACKKGHTDVVEVLLRNGADTRLESKSGHTAQHFAIRGYPELSSLIEEHEKRLGRVIKEAILKCLGDTVSLCKPPILSHRCVVPREGQQMTFPFQYFPQLYDKEVDVILFCIKAVFDDVVSLLFGEDNGVRGVLLNNKPQIPLLHGVRSIFSIDPKSRQNTITLQTHKCNNXASRIILCIYAVQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV42</accession>
    <name>A0A6P8IV42_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031714153.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aten:116304412"/>
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    <dbReference type="OrthoDB" id="5986386at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
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    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
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            <begin position="107"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
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            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
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            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="321"/>
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        </location>
    </feature>
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        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
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            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031570013.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38262" checksum="A9999B35A9EC9F13" modified="2020-12-02" version="1">MVLTKSYLRYEPTGCFGLVGSLKANVLFVEGKVLGLKSSVQLAVVPALEDVFIWDTKKEEKVRVLKGSKWEVTAMAISADQQSLAVGYEDGSIKIWKLSDGTSQVTLSGHRSAVSVLQFDHSCGLLASGGRDTDVILWDVINESGLYRLHGHKGMVTQCRFLKKKNVLVTSSKDMLVKMWDLDTQHCFLTLVGHRSEVWGFVIASNESRLITGCGDSELRVWKISYPANTQDAPASELGAKRSAIDADLENESDVLQSDKQESQPVTCELLGSVIRQSRARVTSLHSSXSGQILGCLGNDSQLELFRITTEEEINKSLQKRMKRARKKQRKEATDPEKAKVYIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVP4</accession>
    <name>A0A6P8IVP4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-2 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116304577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570198.1">
        <property type="nucleotide sequence ID" value="XM_031714338.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IVP4">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="GeneID" id="116304577"/>
    <dbReference type="KEGG" id="aten:116304577"/>
    <dbReference type="InParanoid" id="A0A6P8IVP4"/>
    <dbReference type="OrthoDB" id="5980611at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="61"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031570198.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="61778" checksum="89E8EB362C850E0E" modified="2020-12-02" version="1">MSVSMNTTLNVTASNDSLNSNFTNDTRRRPLGGPPPCPLITTENLASAVCFSILIFMILMGNSLVIASFRVNRRLRTKTNYFILSLAFADLAIGSISVPLWIYITLCPAIQSPMHPNYIXMEIWNVLDVVVGVSSILNLTMISLERGYALMRPIQHRNIKKRIIVFAILIAWSLALFAGCLRPMPLPEDAKKAYGIIVTVTFFIVPLIIILTTYAVIFKIARAHARGRGVRSFKKDLRIATTVAVVIGFFSVAWLPFFSLNFLFSICFRYNISVCRKVPPKIVPYIKWMQYGNSACNPIIYGFRNKDFKLAFKKILLKMCGKDIALTSYTRSTYVKTARNRFVRSDSSFDESQSVLYPDQIVPPGMYDMRESYRSAIDRGHSLPKKRKSPKKNLAHGLMALNVETFSMPVDSPEKNTSKSNPSKPASEVMSDTNSNTADTKSSPSKNGIHTSLDIDIYPYEGTRLARDKGVINESFVKSQEDVTGSQTNRCSSRVSFADTNGIANGGLVIDEQEYHLDLTIPLEQKERSYSDVTPVLSKDDDGPSGNRRSSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW11</accession>
    <name>A0A6P8IW11_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation channel sperm-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571294.1">
        <property type="nucleotide sequence ID" value="XM_031715434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW11"/>
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        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="116305502"/>
    <dbReference type="KEGG" id="aten:116305502"/>
    <dbReference type="InParanoid" id="A0A6P8IW11"/>
    <dbReference type="OrthoDB" id="2984333at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097228">
        <property type="term" value="C:sperm principal piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028744">
        <property type="entry name" value="CatSper4"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47077:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47077">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="119"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571294.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="60197" checksum="406F36E660ED2686" modified="2020-12-02" version="1">MNKASKGLNENETEASTVQESEKTQPAGKSLKSTVDRVRLRLKVASVLGGALQKEEDDKDIAREKEFHAVFHAKQNQEEDPLLQNENDEENMWDIVDMDEEAIEEYASNELVGQFLSNKMFRTGILGIILFNSLLIVVETNEELEKEYNHLFSVLDQCLMTIFVCEILLKWYHGFFMFWKMGWNVLDFFIVASLLLGPLLSKDSGSRGVLRILRVLRAFRSLRSISSLPGLQIVVQTILQSIPDMANIVLLLVIIMLVFSVIGITLFRDTVPKYFGSLSTAMFTLFVCLTQDGWMEIFGAFQSQGDTTYIGGGIFLLVFIAIGAFVFANLVVAVVVTNLEFAMVAVKNEGKEREADDLKSKLEAENDLVNIVSPDDIPACIFNKQMPYQVPEFKNLPIDQLENYITVIFALENNLAEYKKIKAGIVEIFSEVSELQEKAKKEGILKEGGDSHNLPSQGQLPMSGDVISNLMEMESGRVFDSHKDTLSTMLKEGAKRVKHGSRRSSQRSAGLPTTPFSGIFIFNWIHHHVHPSQGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWA5</accession>
    <name>A0A6P8IWA5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116305820</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031571651.1">
        <property type="nucleotide sequence ID" value="XM_031715791.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IWA5">
        <property type="interactions" value="2865"/>
    </dbReference>
    <dbReference type="GeneID" id="116305820"/>
    <dbReference type="KEGG" id="aten:116305820"/>
    <dbReference type="InParanoid" id="A0A6P8IWA5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd14091">
        <property type="entry name" value="STKc_RSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05582">
        <property type="entry name" value="STKc_RSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000041">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000121">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AGC-kinase_C"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041906">
        <property type="entry name" value="RSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="60"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="319"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="420"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="66"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="14 15">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <begin position="426"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="14 15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00009804"/>
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            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
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            <dbReference type="PIRSR" id="PIRSR000606-50"/>
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    <evidence type="ECO:0000256" key="14">
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    <evidence type="ECO:0000256" key="15">
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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            <dbReference type="PROSITE" id="PS50011"/>
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            <dbReference type="PROSITE" id="PS51285"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031571651.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="83371" checksum="0AD89B62330122DC" modified="2020-12-02" version="1">MPLALQDPWQKLHIAELSEAQDEEMMDENRNGPNEEGAVIDVTDELENSKALTKSNPSEFELLKVLGQGSFGKVFLVRKIIGPDAGTLYAMKVLKKATLKVRDRLRTKKERDILVDVQHPFIVHLHYAFQTEGKVYLILDFLRGGDLFTRLSKEIMFTEEDVKFYLAELALALDHLHKIGIIYRDLKPENILLDASGHIAITDFGLSKESEQDQKTYSFCGTVEYMAPEVVNRRGHGQAADWWSYGVLMFEMLTGSLPFQGKDRKDTMNMILKAKLGMPQFLTPEAQSLLRMLFKRNPLNRLGATENGIEDIKSHAFFATIDWDKLMKKEIKPPFKPAAGRADDAFYFDPEFTSKTPQDSPAIPPSATCHQLFRGFSYVAPALLDEDLNSNQKEMKMEVDNNKPSKSLFSVRTTSILEEYDIKQEIGRGSYSVCRKCINKADGQEYAVKVIDKLKKDPGEEVEILLRYGHHPTIIHLRDVYDDGKCVYMVMELMRGGELLDRILKHKCLSEREASXIMYTLTSTIAFLHEEGVVHRDLKPSNIMYADDSGTPESLRIVDFGFSKQMRATNGLLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVLLYTMLSGLTPFAVGPEDTPANILARIGEGSYSLAGGPWDAASDLSKDLVRQMLHVNPRLRLTAKQVLQHPWIVSRHHLSNHRLHHVSSVSKIKDAVKATFSALHSSPDHFRRLKPVQTSLLAQRRTKKTQRV</sequence>
</entry>
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    <accession>A0A6P8IWQ5</accession>
    <name>A0A6P8IWQ5_ACTTE</name>
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        <submittedName>
            <fullName evidence="9 10 11">Neurocalcin homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC116305731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571559.1">
        <property type="nucleotide sequence ID" value="XM_031715699.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_031715701.1"/>
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    <dbReference type="RefSeq" id="XP_031571562.1">
        <property type="nucleotide sequence ID" value="XM_031715702.1"/>
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    <dbReference type="KEGG" id="aten:116305731"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Visinin-like protein 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031571562.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22066" checksum="35100BE18D4AEE2A" modified="2020-12-02" version="1">MGKQNSKLKPEELADLRNATQFNEQELQEWYKGFLKDCPSGNLSVEEFKKIYGNFFPYGDASKFAEHVFRTFDTNGDGTIDFREFICALSVTSRGKLEQKLKWAFNMYDLDGNGYISRQEMLEIVKAIYKMVGSVMKMPEDESTPEKRTDKIFRQMDKNLDGKLSMDEFIEGAKSDPSIVRLLQCDPSSGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXF0</accession>
    <name>A0A6P8IXF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-induced degradation protein 4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571849.1">
        <property type="nucleotide sequence ID" value="XM_031715989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXF0"/>
    <dbReference type="FunCoup" id="A0A6P8IXF0">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="GeneID" id="116305977"/>
    <dbReference type="KEGG" id="aten:116305977"/>
    <dbReference type="InParanoid" id="A0A6P8IXF0"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571849.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23635" checksum="A71CB2D54146C4E9" modified="2020-12-02" version="1">MPGKVAANPLPPSTKQPGLAQSLLYSGSRFQGHQKSKGNRYDVEVVLQHVDDENAFLCGYLKIKELTEEFPTLTTYFDGEVIGRKHPFLTRKWDADEDVDRKHWGKFLAFYQFAKTFNSDSFDYSQLDNIDFVFMRWKEQFLVPDHKIRDISGASFAGFYYICLQKSTATIEGYYYHRSSEWFQSLNLTHIPDHSQPIYEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYE5</accession>
    <name>A0A6P8IYE5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Annexin A13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116306300</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572191.1">
        <property type="nucleotide sequence ID" value="XM_031716331.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572192.1">
        <property type="nucleotide sequence ID" value="XM_031716332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYE5"/>
    <dbReference type="GeneID" id="116306300"/>
    <dbReference type="KEGG" id="aten:116306300"/>
    <dbReference type="OrthoDB" id="5954565at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF175">
        <property type="entry name" value="ANNEXIN A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572192.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38148" checksum="C259C5F80B9442FD" modified="2020-12-02" version="1">MGCSESIQREVFVTRSHRKQTILNWDLESARLHKIVNAIGTDENAVIQILATFKCSERQRIILAYKKTYGKDLISVLESELSLGYQEAATALLYRPEVYDAKSLHQAIEDHENDTLIEIICSRKTLAIEMIREAYQEEFTCSLENDLLSIQDQDLRELLIKFCTINTEGVRSKADRTAAQERAIRLHSYGDLVELLCEPLGRNQLKATFEELETLYMKPIDVYIDNQYKGKSLDFRRALKAYVACTISPPAFFCKELNKALEKNSRSKKVLRIVITRSETDLYYIIREYLSCYSIQLTKAIQKKCLPHYTHPLKIILAIRGQYQESAVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZD1</accession>
    <name>A0A6P8IZD1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Testis, prostate and placenta-expressed protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571150.1">
        <property type="nucleotide sequence ID" value="XM_031715290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZD1"/>
    <dbReference type="FunCoup" id="A0A6P8IZD1">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116305387"/>
    <dbReference type="KEGG" id="aten:116305387"/>
    <dbReference type="InParanoid" id="A0A6P8IZD1"/>
    <dbReference type="OrthoDB" id="9970246at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034584">
        <property type="entry name" value="SPMIP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35348">
        <property type="entry name" value="TESTIS, PROSTATE AND PLACENTA-EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35348:SF1">
        <property type="entry name" value="TESTIS, PROSTATE AND PLACENTA-EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22574">
        <property type="entry name" value="SPMIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571150.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27382" checksum="35A2F289905C57AA" modified="2020-12-02" version="1">MSRMDKPFGNRPYDRQGQRFSKHGPVRPHGTDYNYEPPRRMLVALKQGMMHPKPPTYRRMDMDSFLRKLPIEHSRTSTSRSADDFKSASITLFKPAERPLSGTRITETGRNLQSRGYNPLETGGTAEFLKQNEDERNFQEEMEYRTSTGHPSARYDPREAYTYMPEAYLAKSAQEMRFNGYAARYLAPRLSGGWRYSLRQEPFVDLRGQRPIPATIYSRYRSTHPLISVSSQPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J131</accession>
    <name>A0A6P8J131_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Neuropeptide FF receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116305966</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571837.1">
        <property type="nucleotide sequence ID" value="XM_031715977.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571838.1">
        <property type="nucleotide sequence ID" value="XM_031715978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J131"/>
    <dbReference type="GeneID" id="116305966"/>
    <dbReference type="KEGG" id="aten:116305966"/>
    <dbReference type="OrthoDB" id="5965524at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000368">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571838.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38367" checksum="B4C01F88F0A93CC9" modified="2020-12-02" version="1">MLTAGEIIIRTAFSIVTVTGVTGNVLVCLVILLNRPMRTPMNYLLVNLAISDMILLVFFTPTFIFKGAYTHPTGLAGDLLCVFLTGESFAWMGGYASAFFLVAIAIERYFAVTKPAKSDVSITKDNLKVLVFCCWFFALSWNSIGFAVKRYDEKLGFCAMRWPAHYSFKVYSALTFVVLGVIPITTMCILYSRVVHTLWFKREVIQVNNQEIEKKRRKKVTKMVLIVSLIYTLSYVPELTIFVLFAYAPHSLDVNITYPATVAMVTFNSAVNPIIYGFHNERFRRYLIDLLCCRKTNARVVPSESRGGITAVSSHARHARKKSTLPVSVVDLEVSNTSRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1W5</accession>
    <name>A0A6P8J1W5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylcholinesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571705.1">
        <property type="nucleotide sequence ID" value="XM_031715845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1W5"/>
    <dbReference type="GeneID" id="116305866"/>
    <dbReference type="KEGG" id="aten:116305866"/>
    <dbReference type="InParanoid" id="A0A6P8J1W5"/>
    <dbReference type="OrthoDB" id="5987252at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031571705.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44184" checksum="B3BFEBB0D6C74D38" modified="2020-12-02" version="1">MSVSLLMLSPLTKGLYRNVILQSGAAPAIATALLVNESKEHAKMFADALRCPTLSDLKNCAMKKNISEIITAQLKVNPTLMLAPFAPVVDGHFLEDTPLMVLTKGSYQDEGSVMIGVTRDEGSLALIYLPGLQEGIPDSDKGLNYSVFVEKVNSTTWVRGQNEEILNSIFQEYTNWADTNDVNATRQGFMDANADAIFKAPAILSAQLYDKMGMRTYFYQMDYSAELDFENKTVPEWRRVPHAADIPYVFGHPLLKYPKDLNNTDVKFGKLVMKYWATFAKTGNPNPSSGQNAVQWPLYTTANKQYLSLKPTPEVKSNLLAARMNFWNSYLGTLKSEKKKPCPEDLTQEPPNEKEKALLGLAIAVGVLGLLVIILIIVIICLKRKLKCLTLYSTNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1Z0</accession>
    <name>A0A6P8J1Z0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116305883</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571730.1">
        <property type="nucleotide sequence ID" value="XM_031715870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1Z0"/>
    <dbReference type="KEGG" id="aten:116305883"/>
    <dbReference type="InParanoid" id="A0A6P8J1Z0"/>
    <dbReference type="OrthoDB" id="112749at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34204">
        <property type="entry name" value="RNA-BINDING ASCH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34204:SF2">
        <property type="entry name" value="RNA-BINDING ASCH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="D or N" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571730.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32675" checksum="69E16F12FF53894F" modified="2020-12-02" version="1">MDFICSEFQDLVKNVLKKNQSKKGSTEMLTTDIVDALLERDFEFTTASDPLQSSPNISPLTGENHYPMYPLYKEIANKLFKWMETTQNPSESLQSFELLEQTKVVSLTKKEDLENVGKLLNQLKDSWKNWNVEEREIHIAKVFGILDKRMLLDLLGVRHTVGSIDFFPPPLEELINSFCKKHKPNSNLSVGARALSKHCHRDNTSKFWGVCTGSEDAKNNHACTTLHKILNDVAWINIHSLPHDVKVVEIRCSQGYGARWLHDGSEFRGFLEPQMVDGHSVKWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J344</accession>
    <name>A0A6P8J344_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylmalonyl-CoA epimerase, mitochondrial</fullName>
            <ecNumber evidence="7">5.1.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DL-methylmalonyl-CoA racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116306131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20553"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="EC" id="5.1.99.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:20555"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031572035.1">
        <property type="nucleotide sequence ID" value="XM_031716175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J344"/>
    <dbReference type="FunCoup" id="A0A6P8J344">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="GeneID" id="116306131"/>
    <dbReference type="KEGG" id="aten:116306131"/>
    <dbReference type="InParanoid" id="A0A6P8J344"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000003">
        <property type="entry name" value="Methylmalonyl-CoA epimerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13669">
        <property type="entry name" value="Glyoxalase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="56"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031572035.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20437" checksum="BADDEBB174603602" modified="2020-12-02" version="1">MASRMLGFARRALFSQNKVLLARITTQNSTFKNLRCISTTQRLTTDSSDKLWSLGRLNHVAIAVPDLDKASNLYKNVFGAKVSDSQALPEHGVYTVFVDLGNTKIELLHPLGEKSPISGFLKNKPDGGIHHICIEVKNIKEAMKDLKEHKIRALSSEPKIGAHGKPVVFLHPKDCGGVLVELEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3B6</accession>
    <name>A0A6P8J3B6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Complement C3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574491.1">
        <property type="nucleotide sequence ID" value="XM_031718631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3B6"/>
    <dbReference type="GeneID" id="116308248"/>
    <dbReference type="KEGG" id="aten:116308248"/>
    <dbReference type="InParanoid" id="A0A6P8J3B6"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041425">
        <property type="entry name" value="C3/4/5_MG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF166">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17790">
        <property type="entry name" value="MG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="1">
        <location>
            <begin position="489"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="2">
        <location>
            <begin position="792"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574491.1"/>
        </source>
    </evidence>
    <sequence length="979" mass="109042" checksum="33465802AC4698D7" modified="2020-12-02" version="1">MTYSYKPLHAIEKTSSSRGKRGCNMKMLLYIILFTAASCASAQSYFISAPNVFHVGTPENVSVTVFGINSPITVRLFLQDFPHRRKTFSPVQAVFQTDVPQFLTVRVDPKDIPDQGALDKQYVYLVAKSDDQTLRFHEETKILLSFKDGVILIQTDKPIYTPKQSVKIRVIPLGFDLMPTTKKITVVVKNPQGIRVQQWKNLDTKTGFISKVLDLGDFVLNGNWTVQAFYGHQFIHNTSIKFEVRGYVLPTFSVKITGPSVILPTDISITVGIASSYTHGKSVEGTLAVRIKIVGMKQEPILISSFRMRILDGFATLTIKRRHIMDLPGNIWFPEGRRLEVEADVTESSTGITEHAIENSIFFSSSKYRIKFYKTAKYFKPGLPFSVKVIASYPDDKPAPNIDVRISAKAIKSDGSETDVGRHADDIKDEANRDVTGANGQAEFVIDIPRDVKTLKVKVETAEKGLPLNQNAVKELITRVYTSKSNEYLMLRQTKPVRVGRTVFCDAFLSSGKVDKLSYMVVSRGQIVVHNVVVKKFGVSATISFQVTSMMSPSARLVAYYISSGGEVIADSILLEVDDSLPNQIQIKDNEHEITRFPALEYTVNVLGKKGTRVGILGVDQSVYLLRNDNRLTPKRVFDELENLDLGCGVGSGKDTQGVFKNAGIAVIAPSLAIPGRQDFKCDDSLPRQKRSVNQNSDLDPQTFCCKLGNATDENQRSCIRRVYDLDVPEYTGQKLRECIRHFLKCCVRRFGAKDMGALARSGDFGDFGDFAGPSDDELIEMTQVRSYFPETWIYEEKVIGDEENHIDCQKYLQKDQCGRAMLEATLPHTITSWVVQAVAVSNTSGFGIAKPLHIKTFKPFFMRFTMPYSAQLGEQISILATVYNYNKEETAVKFYLFGNEGFCSAAPSDERVLLTNKDGVKVKAGGSLSLPIAIVPIKYGLVPIKVAVLDSRAFKVDIVEKKLLVVVSMSPSVTRLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4G0</accession>
    <name>A0A6P8J4G0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of basal transcription 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572878.1">
        <property type="nucleotide sequence ID" value="XM_031717018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4G0"/>
    <dbReference type="FunCoup" id="A0A6P8J4G0">
        <property type="interactions" value="2506"/>
    </dbReference>
    <dbReference type="GeneID" id="116306883"/>
    <dbReference type="KEGG" id="aten:116306883"/>
    <dbReference type="InParanoid" id="A0A6P8J4G0"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572878.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="23108" checksum="387826636ABA9366" modified="2020-12-02" version="1">MKPSKVRYIFSQYGEVGRLFLQPEDESVRKKRKKFGGSGRKAFTEGWVEFKNKKIAKQVANSLNNTIIGGKKKSFYHDDIWNIKYLPRFLWSQLSEQIAYEKATREQRMRTEISQAKKDANFYIESVEKGKGFEAMEQRKRKHDEVVPEKNIRTFKQHRVIDDAPTTSEPEKKKSKPSQNTNKINANLLSKIFTSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5H9</accession>
    <name>A0A6P8J5H9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116308616</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031574947.1">
        <property type="nucleotide sequence ID" value="XM_031719087.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J5H9">
        <property type="interactions" value="2233"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116308616"/>
    <dbReference type="InParanoid" id="A0A6P8J5H9"/>
    <dbReference type="OrthoDB" id="5600418at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16450">
        <property type="entry name" value="mRING-C3HGC3_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056527">
        <property type="entry name" value="WD40_RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23419">
        <property type="entry name" value="WD40_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="21">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031574947.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="72013" checksum="B83F8893CCC713ED" modified="2020-12-02" version="1">MSLSEEGVFAVSQDRISSSENGANSSVEEMEVEEQQQSGDRVEENAETSVLNFPSTQQAPEPGVSTLSQENDPPLAPESVXHEAETNNSTPLEARTVPLVNQPIIVESPDEFRDEFKAKSSKRAKISKSPLKSPEKEDEAQCCPICFEPWSNSGAHRLASLACGHLFGKSCIERWLKGKGSNEKCPQCNAPARRRDIRNIYAKALKTIDTTEKDRALEELEKEKKLRQRAEEAEARALLQYQLVKAECERMKITLLQQQELRLASSSSCACKRPNSETRTVGEASSQAFTSNKCYILQGTSQISKGGSRVMSFDEHHALLVISKPSANQLFPGFGVLKVSSLDVKHSEFVQIHQKPLRDACFSCQGDGLLLTAGMDKTVKITSMISNTVVQSYSTPVPAWSCAWDNSDSNYMYCGLMNGSCLMFDVRNTNTFLKNLKTEGDSSCPVISLAHVKPDINSKLRPGGLLVCKLGGACFWESTFGVDYLPHTLMLPEGSCTSLSFEPKTRHCMFSLRPSKNLPKTRHVVCELQGNGIGVSTARAQSEDDPSTAPNEADGSASNVGSLITCNSKMQCVGGPIQKLLSRSSLFTSPDNSESLIVAAPDEAAKATLLWDGFTGNKLQKLPYQGETVLDVLPFTVNGHSFLTTITEQKLDVYRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5I6</accession>
    <name>A0A6P8J5I6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116309000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031575386.1">
        <property type="nucleotide sequence ID" value="XM_031719526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5I6"/>
    <dbReference type="GeneID" id="116309000"/>
    <dbReference type="KEGG" id="aten:116309000"/>
    <dbReference type="InParanoid" id="A0A6P8J5I6"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575386.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25383" checksum="D6CAAAE0E453D7C2" modified="2020-12-02" version="1">MRSRKVNQVHSDIKSIRIVLLGLEGVGKSAFLVRFLTRRFIGEYDQTLESSYKHIVELDGVAVCLDILDTAGEITNCKLQQCKIQGDVFVILYSIADKETFRQATKIGRYLNHFKSPGAPTAMVLVGNKNDLEHFRQVESSQGREFSSELECLFKEISISERTGYEEVNDVIHGALRQYLAIDQPDKKKKLDRRENSSVSYLSKMKEGLMKRTGSIRRKSVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5U4</accession>
    <name>A0A6P8J5U4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116308747</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116308747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031575089.1">
        <property type="nucleotide sequence ID" value="XM_031719229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308747"/>
    <dbReference type="KEGG" id="aten:116308747"/>
    <dbReference type="InParanoid" id="A0A6P8J5U4"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031575089.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48384" checksum="5FFA3E09EBF0A37B" modified="2020-12-02" version="1">IHVPEQIQGILDSTIDGDTKLYGLFKNIPESFSDAERTLIKENVSLIEDKVKPAFKTLLDFFSKEYIPASRESISCEEFPNGKEFYKKVLEFHITCDLTPKQVHEIGLKEVXRIRDRMKQVAKETGFDGDLEAFVAMLRKDKRFYFDSKEELMARYREICFDLIEPKLKDYFKNIPKAKFEVIETPAEAAPTAPGAFYLAPPEDGSRPGTFYVNTYKYEERPNYEMISLSLHEAVPGHHLQAAYSIEQPDQPSFRKHMEDRXYYEAPARFAMNTAYMEGWGLYSEYLGEEMGLYTNLYDLFGRLSHEIMRACRLVVDTGMHAFGWSRQQAVDFMEQNTAMSLHDINSEVTRYITWPGQACAYKVGEIKIRELRENSTHQLGEKFDVRDFHDLFLAFGSVPLATLEEAVNEYIETKMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J788</accession>
    <name>A0A6P8J788_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KATNB1-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116307027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573030.1">
        <property type="nucleotide sequence ID" value="XM_031717170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J788"/>
    <dbReference type="GeneID" id="116307027"/>
    <dbReference type="KEGG" id="aten:116307027"/>
    <dbReference type="InParanoid" id="A0A6P8J788"/>
    <dbReference type="OrthoDB" id="8754475at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042404">
        <property type="entry name" value="KATNBL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14682">
        <property type="entry name" value="KATNB1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14682:SF1">
        <property type="entry name" value="KATNB1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="5">
        <location>
            <begin position="139"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031573030.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34374" checksum="52379F93424A3A0A" modified="2020-12-02" version="1">MASLKKRSASVDNVGHFYYDWALSRYKWTSEEIRNKQNNHSIQENGLSNENGEIRGKKHIDQVQPVGIENLIPLRMNLDDNVKRPLRNRDVNQPIPEERVPIKPVLEQKETTDVKEDGALRKKSVSNEPKDEALELMNSHPAMMSVLTNRLLRLRAAETLWHKDTNAFLEYVLRLKDDALLVDVMPLLTSRVKENAPEGQALSMGACLEMLPALERLLASKFEDYIVVALNMVREMIKRWWTQLKAATSEGNDPKHQRCSRSVNGLYMAMVSISAIIARLKSRKGRVAEKALIVSRLLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J8G3</accession>
    <name>A0A6P8J8G3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tachykinin-like peptides receptor 86C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573310.1">
        <property type="nucleotide sequence ID" value="XM_031717450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J8G3"/>
    <dbReference type="FunCoup" id="A0A6P8J8G3">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="GeneID" id="116307284"/>
    <dbReference type="KEGG" id="aten:116307284"/>
    <dbReference type="InParanoid" id="A0A6P8J8G3"/>
    <dbReference type="OrthoDB" id="5950491at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000368">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573310.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37478" checksum="8A2313FF2A0ED95C" modified="2020-12-02" version="1">MAELYGDNKPAQIGIAVALSMLVMTDFIGNILVILVILTNRSMKTPINYLLINLAIADIMVGLFMAPRFIFSQFFNHPDGIGGKVMCSLLTGANIAWLALVASSASLVAISLERYFAIVRPLSTKYRLTKTKVKRTSTLCWVFGLVINLPLFFIRVYDKKDKLCVESWPKDKQWLAIAYSAVWFIAVGVVPIAVMVVVYSRVVYALWFKRSQQQGTQQALQKSRKRVTKMVVSVSVIYAACMLPNLTMYLLDYVTDQKEYDVQYIISIILYALNSSINPVVYTFQSQHFRQQMKKLVCCGKLPAGVDLEISNISLNKSRSYVVSSATSLETIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J8J7</accession>
    <name>A0A6P8J8J7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574108.1">
        <property type="nucleotide sequence ID" value="XM_031718248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J8J7"/>
    <dbReference type="GeneID" id="116307922"/>
    <dbReference type="KEGG" id="aten:116307922"/>
    <dbReference type="InParanoid" id="A0A6P8J8J7"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574108.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="50714" checksum="AADBC84091AF1289" modified="2020-12-02" version="1">MLATLTMKEMNTKKLTTKSDSERTQQGNVFPAFALFGCFFTSLTSVILAGTQDTLAGTYKPSTTVLLAGVVPLLIVDVIAPYFVNRIPNLVLVFTASISVSVGLIILAYADVEWKIAAVALLAFGVAVGTITIVSLTSYFEPSAVSAYSSGTGVGFLLGPLYYTALTTWFCVSPNTTLTIVSPLPLSYFVLYYFIIKNIRKKASDSDEEVVYTKIDDTDTEDVEDSEIKKERKQETKDKCTRKTDDVFLSRKEKMLILAKLFSLTLVPGFIGFCSQYLLTQTVITTIAYKNAPFTPRDHYQYYFFIFALGEMIGRSHHLILSKTRLLYTPTRLLLWLFSSTEMLILCFAILESWYRFLPNVGILLFFVFFAGFTQGMVYVNMLGLLHLKFEGEEREFVMGYAVVPRGLGMFTAGLVGFFVEPLLLKHCISLFKESTSCLTRSESLVSITSKCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9W5</accession>
    <name>A0A6P8J9W5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116307487</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116307487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573615.1">
        <property type="nucleotide sequence ID" value="XM_031717755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307487"/>
    <dbReference type="KEGG" id="aten:116307487"/>
    <dbReference type="InParanoid" id="A0A6P8J9W5"/>
    <dbReference type="OrthoDB" id="6428524at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031573615.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="65245" checksum="6017C2114DCA143D" modified="2020-12-02" version="1">MEELRCFNCHHKNLTHENVFNVSEIRKTIALQRDTEEEQVPYDARQNGVRVDLDKENVFLVVCADCVYDRLQKCKNCSEKAPLCMFKVGQWFNAKENRVCIDCAAVKESSKLLKDGCEMASLIQQCFRCGHFKYLPSFMVSSKSNVERIPRECTSCLLKADMRKYKKDLHERYQSQLREEPVLVSEHKSSFSKDINSQSTSLSYASVVTKGFSKNSSAEVNYEEDSGEVCEGASVGDRQINKMMKLTTFSASINESICENLLQSLKYSFKQLEEKTKLELQLMQLDLHLCHGILRDKLIRVSHRFSKQGTQQTLFDDAESRWAYMGTYTVAHASLVHATFKSGIFPPLEXFLKNIHQGNKRPLVCSFGAGPGSEVLGLSQHFPPGTEWILLDNCEDWEHLAQVLLTQTAGITFQYGTVDVTSKLPIRTGPKDMFLHTTFKKANLMIFVKFISAVQNQTGAKKYLTSVIRNFSSPGTQFLFIDNAHIQTKTFIEDLVFADGRYVDHGDFKESEHFTLYTTYAELKSEGNDALKSTVLCDWVGYITYWLDRWPTLDLRVNVFLAVKKDKTEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JA57</accession>
    <name>A0A6P8JA57_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116307558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573705.1">
        <property type="nucleotide sequence ID" value="XM_031717845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JA57"/>
    <dbReference type="FunCoup" id="A0A6P8JA57">
        <property type="interactions" value="2605"/>
    </dbReference>
    <dbReference type="GeneID" id="116307558"/>
    <dbReference type="KEGG" id="aten:116307558"/>
    <dbReference type="InParanoid" id="A0A6P8JA57"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031573705.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="33083" checksum="DAEBD2BE98EBA83A" modified="2020-12-02" version="1">MADYDAPISDDEKVRIASNFIKHAPPGEFNEVFTDARLLLNNDSLLKEKGASAFSDYNKEQFTPARLGSSDEQVLITRHGELPDGRFVDPRSKQVFTYDHLRKEAKDLEPSDIDTTAEPWRASIDESFRVYVKDHYPHGVCTVYGKSSGGSITIVACIEDHLFQPHNFWNGRWRSEWSMTFNKNGGETVELKGILKLQVHYYEDGNVQLVSSKELEEEIKITRETATANLFVEIVEKAESDYQKAISENYSTMSDTTFKALRRQLPITRTKIDWNKILNYKIGQELKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JES0</accession>
    <name>A0A6P8JES0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574895.1">
        <property type="nucleotide sequence ID" value="XM_031719035.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8JES0">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="GeneID" id="116308571"/>
    <dbReference type="KEGG" id="aten:116308571"/>
    <dbReference type="InParanoid" id="A0A6P8JES0"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574895.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="55443" checksum="602B620CF8B6AAA8" modified="2020-12-02" version="1">MAKXLERRENDNVCCGCLRAFFRFLRSDLLLTFILIGVVIGFIIGITANGKINXITDVEDRKTAVMLIGFPGELFMNMLKLLILPLIVASLVTAVASLDSKATAKIGRRTVIYFLSTTFVAVVLGIILVTSIQPGKGGKPNVDGKYTPKFRTVDSFLDLIRSLFPPNIAEATFNQRQTKYSSLEAKYREYNKTIETNKQNETSGIIAEFAVNATHKVVTVKELVSRSYSKIPAGTSPVHGSSMNVLGLVLFSIVLGAVLSRMGEQGMPLKTLFESLNQAVMRMITIVMWSSPIGICSLTAAKLVAMDDILKSLEALGLFMVTSIVGVLIHTLIILPLIYFIVTRTNPYKFMAKMSDALITAWGTASSAATLPTTIRCTEEKLGIDPRITRFVLPLGATVNMDGTALYEAVGAIWIAQMNNIPMGAGKIITTCLTATAAAVGAAAVPSAGLITMVIVCQAINVPAEDIGLIFAVDWFIDRFRTXSNVMGDAFGSGVVFKLSKEDLLHDDPLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYR3</accession>
    <name>A0A6P8GYR3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat and IQ domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031548663.1">
        <property type="nucleotide sequence ID" value="XM_031692803.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8GYR3">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="GeneID" id="116286326"/>
    <dbReference type="KEGG" id="aten:116286326"/>
    <dbReference type="InParanoid" id="A0A6P8GYR3"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000084">
        <property type="entry name" value="Abnormal spindle microtubule assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF8">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1457"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1490"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1271"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1415"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1461"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1492"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031548663.1"/>
        </source>
    </evidence>
    <sequence length="1521" mass="177330" checksum="5F4FC54B102C4AB2" modified="2020-12-02" version="1">MMTGIIGDDEAEIEAEIQRELDEICEDNIEIEDLENEDLISPYLNEKDADVLPDSLQQYLRAVQSRTEGVEQDVRDCDTVLNKLPIGGINDDDEQILARKIKEALGDGCHDDPLDIRKKVLSEIEELEQNEEKEKIRRESNADNMAIDIIRTDISDQIRILEEAAEKQLLELEEKQANKKQKRNEWYEDMKREENKRMEKVQEMKRQRQQELETAQKRLNESQQVIQKMLEKEAEQGKQKLDLLQQQFQVDIQEIEEESKKEKAALEEMKNQEAEYQRKKQNAAAVKIQKTYRGHRVYLQHKNILQQRRSERIKKYEEELEQQEREEKKKMEEVERRKQEEKRNEELQEKKRIEEERKRKEEQWKREREEEKQREEEKKKLEQLKKDEEKKKKIEEEREEQKRREEKRKIEELKKEEEKKRKEEEEREEQKRREKRKIQELKKEEEKKQEEAKKKELELIEKRKKEEEEERRKAEEKIREDELRKEIERKKEEQKRIEEEKKTAARRKKLEEIEKQKMKEEEKMKEEQRESEKKKMENKSGNPDINRNSTKLEGSEEIQNCLGLRHLEERRLQWVQEYLNVMVFSSTTSEDRVQPVAKMKSRQRPRRPFSASKNLPSLTEEQLLQASPPMTTLNKVVRVCVSSLPACNMHGVKRCPDLQSLTIHNCGLMAVESIEECTSIRELRVQDNCIEYVSCRGIHNLEEIQLNNNNLTSVQGFDGCRGLRCLYLSNNKITRLGDLSSCCKLQTLCLDSNQLIMTKGLLSLPNLQSLSCANNHLPNVKEIDSCQLLQSLNLQGNNLQQPPVLSNHVLLRELRLDDNSISTLEPLSKVWLPSLRLLSASQNSISKLDSLEGLIMLETLDVSHNLISDLDWLIPGLSQCRELKVLRIAGNPVNEDPDCRKAIVESLAFLTKLDDESLQPKKSSSEGHSSSFITMCLNQLTEYDNMMARHDTELSSFSESEVDPKKVQERLNIKSKQFEERHQLAVTHLQQHERYGTGDEHLNLSRDAPRFTEKDPKIMETMSRHETCEQPESRQSHDVSVTLKAKASEPYSFEGVEAGRADEQRKTLADDSSILTTAAIKIQSVWRGWYVRHLIDLQMNKWLAAVTIQAAWRGYRVRSRMRKSRVSRARKALWDARDHAAATTIQACYRGYRARKRIASALQAVNYYNDDDDDDDFNYDEEVDLSAFDYDSGLLDEGWTPTDTPQLPSRGPILPGPGQSSFHSRSKQSEAYMPRQAWRSADSPMEQGLLANQRGTPRVHNDQRSPEQDLMSVTSGTQSHLTHRQEEMSSEWGVRDPSTAELMWKRANRMKYNPARKRKLLDPNKRLALFKKLDEANKLREVKPPPKRQPQRVDYFAARDSSMLPSGSNTPTLERQAKAQMTYSWVYNQGVIHVDQDEPGRLGLTKDYSTEPTKTKKSPGKRYPSKSRSPISLPQMDPVALTGRNVPLVSSPALIREQISKDSTPTTRRYSSASEQIHFPPIKTYSVPNLTARSAASEASSLSPEKSNSAGARMTKERKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZD0</accession>
    <name>A0A6P8GZD0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Bifunctional coenzyme A synthase</fullName>
            <ecNumber evidence="20">2.7.1.24</ecNumber>
            <ecNumber evidence="4">2.7.7.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116286485</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:18246"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="18">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the central section; belongs to the eukaryotic CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="20"/>
    <dbReference type="EC" id="2.7.7.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031548868.1">
        <property type="nucleotide sequence ID" value="XM_031693008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZD0"/>
    <dbReference type="FunCoup" id="A0A6P8GZD0">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="GeneID" id="116286485"/>
    <dbReference type="KEGG" id="aten:116286485"/>
    <dbReference type="InParanoid" id="A0A6P8GZD0"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000899">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="22">
        <location>
            <begin position="158"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00066359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031548868.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="59347" checksum="B36F2292AE0778C2" modified="2020-12-02" version="1">MFRCGLLVINPSCIKASIPQIIKVASKDIRDVLYVDLFNSKAACLSTTYSLLLQVYGRSHRSLGNVDIKVLLPELGQPKPRVLSKQPDITLVVDFPESSEEDNTLDNIKTWINERFWGLSEVQSRIVHLNKDLSLLSSESSIDLASIPSLKVYDEVALGGTFDRIHDGHRLLLGVACLLCERKITVGLSDGPLLERKVLKELIQSFEERKRIVEELIEDIRPGLQHNIVPLTDPIGPAGTDPNLKCLIVSKETEKGIAFVNEARRKSSLQDLEAHVIDIVTEETAMFTPGKSDDAEKMSSTIERHKLLGKLLRPVKSIPRKRSSERPYIIGLTGGIASGKSAISKRLEKLGAAVINCDLLGHLAYAPGKKAYGQIVESFGEEVLANDGTINRKALGTIVFADKDKLSELNKIVWPEIMNLVEEKISIFASQGAQVCVVEAAVLLEAGWDSVVDEIWVTFVPEGEAINRMLSRDKMNEQQAINRVRAQMSNEDRVSHAHVALSSLWEPEYTQKQVERAWKGLQERITALPSNQSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1Y8</accession>
    <name>A0A6P8H1Y8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116287850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116287850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550404.1">
        <property type="nucleotide sequence ID" value="XM_031694544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287850"/>
    <dbReference type="KEGG" id="aten:116287850"/>
    <dbReference type="InParanoid" id="A0A6P8H1Y8"/>
    <dbReference type="OrthoDB" id="5964629at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031550404.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48178" checksum="B959044455F2697F" modified="2020-12-02" version="1">PPGVEPITIDDLDDPASDADLLTPALECTTSPEKALHLFQKQTIVATPKERIFLSRLDGIPEMKREIMGIYKNPQTNLHRAPRVRFEEEDGIGCGPVREFFSNVIKIIEEGISSSSSKPLMFLEGETDHRLPIHDQSLRAIGAFKAVGRMISHSVLHGGPFVYGLSPXVKQYLSTEANDKQLSLTLAIEDIPDIELRQLISELDELLLDQNVSPEQRLAIQPYLFEAGLDPDELNQNRKFLLDGLMTYNVIDKRRLELDDIIKGKSSIQYSLYIYKLLFIDICTGMNEVSLXRFLTRFPTLATLIFPSECERVIYGSDIKAVITNEEKDLNECNKRAALWFNDYIDDIETNSEDGAKLVDLVCFWTAGGLQVSNGQLLVKFDGGANNLPLSETCFKSIILPTKHEEYSSFKKNMDIALKYGSKGFSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H322</accession>
    <name>A0A6P8H322_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Elongin 18 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SIII p18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116287316</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (either CUL2 or CUL5), a catalytic subunit (either RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1 or RAB40C. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Elongin B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549841.1">
        <property type="nucleotide sequence ID" value="XM_031693981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H322"/>
    <dbReference type="FunCoup" id="A0A6P8H322">
        <property type="interactions" value="1422"/>
    </dbReference>
    <dbReference type="GeneID" id="116287316"/>
    <dbReference type="KEGG" id="aten:116287316"/>
    <dbReference type="InParanoid" id="A0A6P8H322"/>
    <dbReference type="OrthoDB" id="7537057at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000108">
        <property type="entry name" value="Elongin-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ELOB"/>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
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    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="128"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060803"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074516"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076690"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080438"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083653"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031549841.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15333" checksum="E213ED393B566296" modified="2020-12-02" version="1">MKCRPSECYPPYWEPSSEMAMEVFLMVRRSKTSVFLDCKESTTVMDVKKMIEGILKRPPEEQRLFKGDQVLDDNKTLGDCGFTNQTAKAQTPAILGLSFRQDDGEFESLCIDALSSPPELPDVMKQQDPGTSNSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3H5</accession>
    <name>A0A6P8H3H5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein C5orf49-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116287607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550153.1">
        <property type="nucleotide sequence ID" value="XM_031694293.1"/>
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        <property type="interactions" value="49"/>
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    <dbReference type="GeneID" id="116287607"/>
    <dbReference type="KEGG" id="aten:116287607"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027901">
        <property type="entry name" value="CFAP90"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34444">
        <property type="entry name" value="LOC361192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15074">
        <property type="entry name" value="CFAP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031550153.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21173" checksum="882CFDAE158FA4ED" modified="2020-12-02" version="1">MSEMVRGFNFSYYPKDEEVQEALDTLKPIGILSKAYNQHQLKKQKREESIRNNHIVTQGEEAVSSSWKITRXEPLDLNQDTSYFKAKTKHEKPSTYDRINSVVVGYNQKLHRDDREHAKSRGLNVNREETALKVPALSSSVYGHPSRRPLEFQDRKHVRVELCKKDFLRLNGTLISNDPDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H960</accession>
    <name>A0A6P8H960_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 115-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552964.1">
        <property type="nucleotide sequence ID" value="XM_031697104.1"/>
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552964.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39174" checksum="4DB9592BB541907A" modified="2020-12-02" version="1">MDASLNQLKAQINKSLGDASVVVKASCLLVCLLYLLTFIPSFWSALAVCPGFLIPPNFRIWSLITGGFLEYRIWNVAIDVLVLVLCGKFIEPLWGALEFLKFVIILDVGTSLVTTLLCLFIYLGTFNTHIWFLQFSGMTGIISGLVVAFKQIKPDENLYNGLVNVRIKQIPGIVVLSYTILCLVGILPVIQLALVVSGILIAWVYLRFYQPRARGSRGDLSEDFSCASFFPEQIQHPIRTVSNXIFNFMVKIGACAKPVRTYDVGAPSAITISLPGIDPADAERRRQRALKALNERLQKLDQAQGSWPSMEDQGEKDENIPSEDTTLDETPTVVIDKGNPTNPEGHRSTAIIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9D4</accession>
    <name>A0A6P8H9D4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Uncharacterized protein LOC116290200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC116290200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553064.1">
        <property type="nucleotide sequence ID" value="XM_031697204.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553065.1">
        <property type="nucleotide sequence ID" value="XM_031697205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290200"/>
    <dbReference type="KEGG" id="aten:116290200"/>
    <dbReference type="OrthoDB" id="72419at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653011" evidence="9">
        <location>
            <begin position="20"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="6">
        <location>
            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1295"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1352"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1373"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553065.1"/>
        </source>
    </evidence>
    <sequence length="1506" mass="167119" checksum="33E63B85D46C87B0" modified="2020-12-02" version="1">MYMMLVTLLIFTVFRLVVTTHGQGSSGFLLFTDSSQGFIYKANRQGYGLLSSPKIIIHSSFTPQAVSYDATEQRVYWSDAFTSTISRAFLNGSSEETIVRYVKAVAIAVDPAGRNLYWADNKKGRIEVARLDGSHRKILVRTKRPTDMALDLTRRQMYWSSDSFSAAIIERSSMDGSDRQVIVSGLIYGAPSGLCLDSGKRVLYWTEKNAPQIFYVSLDNPSGHHLYYFQARRSKPFKLTILDQRIYWTDRGSYYYHGKVASLNITSKKDLKILANNVDKPKGIYAFAGDGSLIPESNCSRNNGGCSHLCLLSPRQDRVCACSNGMALKDDGKTCHYKEFLLVVDDVRRKIFHKSLDDLSRPKTPLALGQTGRIMTVDFDPQEHKIYWTNKRGVISRAFLNGSSIEAVVNSLNYFPRGHEIDVIGRNIYWFDSKYREIGVCKLDGSWQKILMTLNEQPEAMVLDSSKGVIYWVTTGNTAIIERAHMNGENREVLVRFPRRYHYEYSPRALALDSDNNRLYWVDDNRGELCYTETNPKTGQIHHVGISSWYTISPYSLALKEGYIYWGDGSNAAVYRVNKTSTRKVIKIVSSVDAVDLHVYHNNTQVLDNNHPCAHFNGWCTHLCLLKPGGYSCVCPGNKGSRPCYTTPVVPTPSSHYLSAMSSTSVYIPHIETASSVLPQTKTTRFLLDHSTLLPTSSQHYTTTFARSSPLRLQPESTLETSMFVTTTPSRLYSTTSLPSLVSSLSPTPSSPLLSSSSSPPSSPLLSSSSPPSSSSSQSPFLSSSSPFLSSSSPPSSYSSSSSAIRIPTLSSVIPNSPPTSIKWTPTSTSVPQESSSSVQVSTLYTSITTSSEPTSSVAHVISSPAKVLPSTHQVPFTSSRLLLSSKRYSPVITAAGSVMTSVFPHLPVLTSSYTFSSIFMSTTTSSSTNYGFTSSPSPTLISPSLISCTSSTVLPSNNYLPSHALSTIKTISTSPSLSSSTVYITSTTLPSSASIPVDKCHPDCQVGEICVEPWYRCINIGENKVSLLFKMNEIQWSNDTLKNSVSKASTQYCTNQSCLELLRPAEPIRSKRATKPNIVFQGSDVLVLNNPVSWSATDEALVVIAVLVPSNYESLTTTGTRRVVTKQNLCKLIWESRHLINRYMKGASMIRLDGQTQPSCVVLGGDALHEQRQGNSKGSATTISVSILGVLALFLLLFLAMFYIRRRKAKQNVPRPYHTQISFSNQGFVDGFVDNDYEAAEASLSNPAYAEIDQVMNNKRQSGEAKKFLKTPFVEPVKNTNVHRDNRVFQNTKEFWNPGHNSRPRPRRTGNEVIINPSNLDACADVNFRPESSEYSTPIPVIPKYMPLSSNQATKSRDRDYAHLNPGTRKLSTRDQPHKRGLEGSGSHDYESVVGPGIKNYVRRAEAETTSGSVVRDDYDHLRQGGKTTSPNKIDDHNIYDHLQRGGKTTSPNRIDDHNIYDHLRQNQGNTYDHLQRGLTIPQQNRQHTLQLKKDDDDVVEETVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB80</accession>
    <name>A0A6P8HB80_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Scavenger receptor cysteine-rich type 1 protein M130-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552378.1">
        <property type="nucleotide sequence ID" value="XM_031696518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HB80"/>
    <dbReference type="GeneID" id="116289574"/>
    <dbReference type="KEGG" id="aten:116289574"/>
    <dbReference type="InParanoid" id="A0A6P8HB80"/>
    <dbReference type="OrthoDB" id="422749at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="97"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031552378.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20198" checksum="096080407E1318DC" modified="2020-12-02" version="1">MLFGISEVYHQRQWGTVCQGYWDIPDAKVACRQLGFAKAVGASHYGRGTELGQWGTVCHSDFDMRDAKVACHQLGYAKTVGYWWYGRGSGKVWLFILEVYHQSQWGTVGRNGWYTEEAQVTCRQIGFTKAVGFSWEGRGTGKVWVNYMACTGSESSLGSCPHDGWGNVGSGCNTHQYDAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEF6</accession>
    <name>A0A6P8HEF6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-containing protein Dlish-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116291127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554106.1">
        <property type="nucleotide sequence ID" value="XM_031698246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291127"/>
    <dbReference type="KEGG" id="aten:116291127"/>
    <dbReference type="InParanoid" id="A0A6P8HEF6"/>
    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="441"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031554106.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57277" checksum="98FFACB7ACCB1D46" modified="2020-12-02" version="1">MAFLCPVRIPRRRRKRRDGENSTKNGAPKSRITGSNSVDSLVALGKDNEEEEIEFEPRKMVVLHDFIPCVEDEVLVKRGEHVRALYQETDWIYILKLDNKEGFIPFTYCVTEEEYEKRKEKQKTVSSGSKDFLKSPLLEAMVTQSSFEPAEFAKENHGDFIVKFDFEATEEDDVSVRKGEVVQVLNKEDQDWYWVKKKSGKEGFIPKDFVTKIEQTEPSRSLTSRGQLSRSNPNIYSSSKMSPHSTVIAASSCTSFSRTDQTPLPANTCAIPLSSTRRMDNYSSSGTNSSRSSSHTPVISADQSSTSLXRFEQNSPYSNHVPALPSFAPVVRNTPDRKMSHPSSSNALDKRENVFTLVSQCDYNMTTPNNPRVSTASTLLITDENHNLKQPNPNVRFKPFSSMSRLDQRHSVPGNPDAYQLSQSLGRSYNQSRRSSNDLLLYGQELVCTDTHLGREADEMTVYKGDWIYADMKCRDGRGWVWAYSPASKNQGFVPKSCLRPPATTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFA7</accession>
    <name>A0A6P8HFA7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 70-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116291415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554446.1">
        <property type="nucleotide sequence ID" value="XM_031698586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFA7"/>
    <dbReference type="FunCoup" id="A0A6P8HFA7">
        <property type="interactions" value="2996"/>
    </dbReference>
    <dbReference type="GeneID" id="116291415"/>
    <dbReference type="KEGG" id="aten:116291415"/>
    <dbReference type="InParanoid" id="A0A6P8HFA7"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001933">
        <property type="entry name" value="WD repeat-containing protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031554446.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="73128" checksum="49FAA312F3AEB381" modified="2020-12-02" version="1">MDEEDLEEMTALRGNSKYLISQGSARSGFGSFGPSRQKPAPSRSRSDVPSSCSVKTTPQAEDKSSEQREASDMAAMMGFSGFGKKQALKFNVEEMFEKARSTAKQVSMAATIKESSQVDDNDEGPSVMLPPWMERKEEKASTSKLETKDDDDDDEDDEDDDDKEEVENRLPISHEVVLQHGSKTISAITLEPSGSRLLTGSHDYEIKFWDFNSMDATHRAFRTLQPFECHPIKSAQYSITGDCILLTSGNAQAKVLDRDGFQVLECVKGDQYLADMANTKGHVATLNCGRWHPKVKEEFLTCSDDGTLRLWDVNNHNKNKKVIKTKNKMGKKTIPSHCCYSKDGKYIVAACQDGSIQVWDTKRPFVNTTFMKRDAHSSGSETSCIDFSHTGNVMVSRGGDDTVKLWDLRNFKNPVNVAIGLENHHAQTSCYFSPDNRLIVTGTSVRKGEGDGKLVFLNKDTLQPEYQFKVGDSSVVSSLWHSRLNQIVVGTSTGTVKVYFDPEKSNKGAKLCVGKVRRQKVQRDMPLPDHIITPHALPIYRQSQPRNMKKVKEKQRKDPLMSNRPELPVTGPGKGGRITSGMSLSAFVVKNIALEKADDSHPREAILKHAEAAKSDPYWVSPAYDKTQPIPIFQEPEEDDDEDDEESSNKKIRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFH2</accession>
    <name>A0A6P8HFH2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291495</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031554526.1">
        <property type="nucleotide sequence ID" value="XM_031698666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFH2"/>
    <dbReference type="GeneID" id="116291495"/>
    <dbReference type="KEGG" id="aten:116291495"/>
    <dbReference type="InParanoid" id="A0A6P8HFH2"/>
    <dbReference type="OrthoDB" id="5987099at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554526.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26369" checksum="A103AF122FD53B3B" modified="2020-12-02" version="1">MLNILTKARPSQNVRDMYRYRCGYGPCVVFQKDALFQDESYESHYPAFQQLMGDLEVQRNGNFELQQERIQSSEYLLLPGDIAAINPGSNNGIPSADKWWLLQVNKAHPADRTASGYHVFGFWLNEEPATNDNSVEGRNFHLLTPSVKVYYGSIIKDIENKLPVVVPVEQLNAGWNNNSVSYVFTDEYCSKLDLISDKFRQDLELPESSNESADEETDEENEETNELYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFL2</accession>
    <name>A0A6P8HFL2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116290808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116290808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553778.1">
        <property type="nucleotide sequence ID" value="XM_031697918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFL2"/>
    <dbReference type="GeneID" id="116290808"/>
    <dbReference type="KEGG" id="aten:116290808"/>
    <dbReference type="InParanoid" id="A0A6P8HFL2"/>
    <dbReference type="OrthoDB" id="5961158at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36191">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36191:SF4">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="236"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031553778.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36110" checksum="FCDEF10538B61D4F" modified="2020-12-02" version="1">MASICVASNREGIKKMIVKAKGDIQYKKSSINNTVVYTNETVTCEADGSPTPYVAWVRLGVVLVNKKSTAEITITENNGEYVCVASDREGIKKLIVKAKAPLQLCHDHLIITDVSRAVNHIFQSSQVKSDVSDIDLSKWYRIQSPAGNQLPTTCVPQNRCGTQAPGWLNGTLPSVQDGIVKKTVCFHFNGDCCYQNATVHIRKCFGFYVYKFSAVPKQLPAPRHCIQNEHIDTRDCPYFTFATSENSREGLVGHVMYSEAEVQKDLICLNYCIILNDCKSFNYSKEKKICEINNATRQEYPEAFVKNDAFAYYEKMFTSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGH9</accession>
    <name>A0A6P8HGH9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IQ domain-containing protein K-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116288959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551687.1">
        <property type="nucleotide sequence ID" value="XM_031695827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGH9"/>
    <dbReference type="FunCoup" id="A0A6P8HGH9">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="GeneID" id="116288959"/>
    <dbReference type="KEGG" id="aten:116288959"/>
    <dbReference type="InParanoid" id="A0A6P8HGH9"/>
    <dbReference type="OrthoDB" id="2155538at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22969">
        <property type="entry name" value="DD_IQCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043408">
        <property type="entry name" value="IQCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34927">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34927:SF1">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031551687.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32643" checksum="2C5D62D1A22AD4ED" modified="2020-12-02" version="1">MYVAACSPTSSIFSEMLELNALRYSSKKEVFEGEMFDGKSYDASKCSPVFVGRYGHKLGDAEDFDDVGSTRSSLLPDYDPATTHPATYGYVLLDKKPPVTKEEPILPNPKECNPREYLETYIFPILLPAMEKMLVAAKENKVFERRRTKFNACDFLTEYLYKNNPCFKDRERLSLLDIPFVERILAKNPRTPLPLSLLLSDEEAAIIIQSFYRGYCVRKRPDVQELREYQREMRNEAVDIFLKVEDFWKKHPIDDSLDDEVTIRMEGTDALTSPTRTETVSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGL5</accession>
    <name>A0A6P8HGL5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292383</name>
        <name evidence="8" type="synonym">MED9</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555554.1">
        <property type="nucleotide sequence ID" value="XM_031699694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGL5"/>
    <dbReference type="FunCoup" id="A0A6P8HGL5">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="GeneID" id="116292383"/>
    <dbReference type="KEGG" id="aten:116292383"/>
    <dbReference type="InParanoid" id="A0A6P8HGL5"/>
    <dbReference type="OrthoDB" id="5950777at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039242">
        <property type="entry name" value="MED9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031555554.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12018" checksum="AFF517A21078E6DE" modified="2020-12-02" version="1">MDDPSSPEKVDILGEFNLLPAIFDIINSVQKTGDTQEMVKKVNNFRAKLQHCRELLNTVPGLDMSCEEQKALLEKHKKELERKSALVVKYKDLPVFSEAIMKEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGW0</accession>
    <name>A0A6P8HGW0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein 594-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555081.1">
        <property type="nucleotide sequence ID" value="XM_031699221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291987"/>
    <dbReference type="KEGG" id="aten:116291987"/>
    <dbReference type="InParanoid" id="A0A6P8HGW0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555081.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20745" checksum="87458975A2B0DB10" modified="2020-12-02" version="1">MDCLKCKKVFSTKQRLQYHVWHGVCTKKPISKVCDDCNREFSTLQKLQYHVKKGICRRTTQCSYCXKVLSSRQRLQTHKKRHEKSYQFFAEKYDLEGVDCYQCGDLMSRCEHKDDYLRNRIDYFRKISRTLPRFDALEGAPWTNREYWRQQCERCGCVREEEHIFNCLFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGY0</accession>
    <name>A0A6P8HGY0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289064</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551815.1">
        <property type="nucleotide sequence ID" value="XM_031695955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289064"/>
    <dbReference type="KEGG" id="aten:116289064"/>
    <dbReference type="InParanoid" id="A0A6P8HGY0"/>
    <dbReference type="OrthoDB" id="10430778at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551815.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21507" checksum="35B5F92C314BD2FD" modified="2020-12-02" version="1">MLTLTRKSCGKCIETKKELHRVQKQNSRLWGKISCLQTEIITMRENPRYDVEGEGDTNEIDEEKESDGEHLREELEDLDDTESEIEPMDTEDVDWAATEXDINNLEEESHKTTTQSIEVEPNTKSQNEPKFIVFYCMLLRFSIFCFKCRGGKPVEMKTNEDNNNIRRNYYCQQFLKQIFIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK36</accession>
    <name>A0A6P8HK36_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynein assembly factor 5, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556171.1">
        <property type="nucleotide sequence ID" value="XM_031700311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK36"/>
    <dbReference type="FunCoup" id="A0A6P8HK36">
        <property type="interactions" value="1354"/>
    </dbReference>
    <dbReference type="GeneID" id="116292953"/>
    <dbReference type="KEGG" id="aten:116292953"/>
    <dbReference type="InParanoid" id="A0A6P8HK36"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000746">
        <property type="entry name" value="Dynein assembly factor 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="5">
        <location>
            <begin position="44"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="4">
        <location>
            <begin position="344"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like HEAT repeats region" evidence="3">
        <location>
            <begin position="678"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031556171.1"/>
        </source>
    </evidence>
    <sequence length="864" mass="97721" checksum="9113B7CC42ECF535" modified="2020-12-02" version="1">MKLSFPVLWKTRGRRVFKMAAVLSPSDTEDFEVVLQVTQRDINCLSDDNRTTRRRALDKILKDVLQRKPPLSAQVLQSLLDELVKPLLKVMSDPTEKCRDLSVQIMSEFADKIVDVSVFLPYIIPTISQRLGQPEIVENCEELRLALVKLLTTVTKLCQNKMAVYIDDMIKIFQRTNLDPFHEVRKESFKCINVLAPAIPEQFYFQGNSLVSSLLKTISHQHSKVRVACIETIGVVIQYGDGKNVDDVTSHLAQRTFDSSPTVRAMVTSVVGDWLLNLRDRYSYFHKLLPYLLTGLSDEMPDIRNKSRELMDQVGDLYAKENEEELKDKINFDEPPTYRLITDIPRPSLGCRILIHRNLSKILPAALRDMTDWTVDTRKKASALVYNLLFYAEDNTTQHMEVLLNGLYKGCQDEEKEVVSQVIASAELAGSFVDPAVFCKLALPHLKTSATSSSQSCTNCLTILAALIHGCNPELLVPQLQYICETICLPEVSCAEQQSTQQQLLILVNAVLQKAGTHCTQYSYQLFTVIMHVKALQTQSGLEEEVMASLQMLATIQNLQSIQQLYEKHSEELLTKLKASHMSWTSHSPERQLFDVLLTNAGPVTGQVLLADAMPIFASCFDINRDPEMRLKTFSLMSRLVMDASKSEVSIDAFKEYSLAIVKDMIIPNCVWQTGRTASAVRAAAVSCLWAVLQAGLLTDQQAKDIMKELLTQLNTCLDDHNQTTRLVSCKALQKLLISCKDSFNADTLHQIYPELTKRMDDSSDEIRIMVTKTFLAFFRAFPADYDRDLYKFHLQSMFKGLLIHLDDPTASIQESVLAALLEAVHIAPNILQEQVEAVKHKHRVARFCNEILKEIQSHTAMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKF8</accession>
    <name>A0A6P8HKF8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC116290318</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC116290318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553177.1">
        <property type="nucleotide sequence ID" value="XM_031697317.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553178.1">
        <property type="nucleotide sequence ID" value="XM_031697318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKF8"/>
    <dbReference type="GeneID" id="116290318"/>
    <dbReference type="KEGG" id="aten:116290318"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031553177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553178.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="42622" checksum="E98342D2581A72C3" modified="2020-12-02" version="1">MAINVEAVEKAFEWETFEDGKPYLGTYKHEIPNRVRMMTMKLDPKDWIKIDRTYASQQHEKERLWQTLRDKVFVTNNNESTKLAKSELLQMICKYLPERYPDKFEAREGGVYNKMLQEFISTSEEPGEEDPLIKCGRLTQEDWCIMEWSDEHQAYCLTAGMVYFPMRWSLQEKWNLPMLDIHQPVDGFTKHLKSLVYNLFKTMAPDAPVYRGNWAVFNDLEGPLDLYTPVGHEHRNAAMGGVRPYEGEKTGRVLTFRCEYQTLRKLEKSKAIVFGIRTYQIYLEDFKKFPRKDTETLVKVIENIHPDFVEYKGARFWKDAALKYLRRDVLGEKESPGIVSFWKKGSALVVGISVLALAIALMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM15</accession>
    <name>A0A6P8HM15_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Protein phosphatase 1 regulatory subunit 32-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116292816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556028.1">
        <property type="nucleotide sequence ID" value="XM_031700168.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556029.1">
        <property type="nucleotide sequence ID" value="XM_031700169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HM15"/>
    <dbReference type="GeneID" id="116292816"/>
    <dbReference type="KEGG" id="aten:116292816"/>
    <dbReference type="OrthoDB" id="9980630at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031410">
        <property type="entry name" value="SAXO4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34349">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34349:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15691">
        <property type="entry name" value="PPP1R32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556029.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51600" checksum="859BDD157E288691" modified="2020-12-02" version="1">MGRLPYGPGNPHILQSKGADKGVMKFYCTEYSTHYGQEGFNPRTGKHVGTGYQSNFRPGVYYSRKLDELDNPAMGKIVSDNYASITKKHFLPSKGSQGFDPFSRGLHMTATSGFVKDIPGNLPKSHQVASVHIDTRRQGTVYPAHRPLLHTLNQKDPIQRENAFHGPLYMSTEARTRFLGLPSERMNTSCKTVGHKEGSGFTHAYNDEPVLFNPMEAYEGLKDPRFTSRPTGYSVMKGSFRPVEYQHGNEEFPILSHASDRNTGFTHGTKVKPVFYMKLNDAYTKQDDLHPRIQQRVQKIDPCEYSNIIKPYTYSSTSKLAFRGKQCNDPSEAARLGNTSIGNKEPTGYSENNDKFFETAETEELLRRFDTHYNAKLYNMNPAGDARMGHTRGNLQTQLPDGFTKSTSVHKFGPDINTTVQLRGQKPYQARSIKARDPFFDDHTYDKKLHTTQAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMC7</accession>
    <name>A0A6P8HMC7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-secretase subunit Aph-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553805.1">
        <property type="nucleotide sequence ID" value="XM_031697945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMC7"/>
    <dbReference type="FunCoup" id="A0A6P8HMC7">
        <property type="interactions" value="1335"/>
    </dbReference>
    <dbReference type="GeneID" id="116290836"/>
    <dbReference type="KEGG" id="aten:116290836"/>
    <dbReference type="InParanoid" id="A0A6P8HMC7"/>
    <dbReference type="OrthoDB" id="6507463at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553805.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27264" checksum="5119B3818477BD63" modified="2020-12-02" version="1">MTLMVFFGCALIAFGPACAMFSITVAGDAQQVIVFITSAFFWLISLLISSIWWLVVSPLKEQIAFGMTFSVLFQELFRLAYYFLLRKADEGLVSMINNQSPLRKHRIAYVAGLGYGTMSGLFAMVNVLADITGPGSMGLRGDPQNFLIVSAFLTSCFVLLNTFWGVILFESFDKKKRWLNLGIVVFSHLFVSLMTLLNASGNYIATLISAYLVMIIMGVIAFNSAGGSCFNIYRLIMTKKSHVNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMH8</accession>
    <name>A0A6P8HMH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine/arginine-rich splicing factor 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116293609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556921.1">
        <property type="nucleotide sequence ID" value="XM_031701061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMH8"/>
    <dbReference type="FunCoup" id="A0A6P8HMH8">
        <property type="interactions" value="2177"/>
    </dbReference>
    <dbReference type="GeneID" id="116293609"/>
    <dbReference type="KEGG" id="aten:116293609"/>
    <dbReference type="InParanoid" id="A0A6P8HMH8"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000028">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000420">
        <property type="entry name" value="serine-arginine protein 55 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="170"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556921.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36431" checksum="35CFFC6935D6C9E1" modified="2020-12-02" version="1">MSCRVYLGRLPYGTREDHVKKFFRSYGRLREINLKNGYGFVEFEDSRDADDAVYDCNGKELLGERILVEHSRGTARGYSSTKPSRARDKYGPPTRTPWRMVIENLSSRVSWQDLKDYARQVGEVAYGDAHKQRQGEGIIEFKSKRDLKRAIRKLDGTELCGRRIKIIDESPASRSRSRSRSVSRSRSRSRSRSRSRSRRRRNRSRSRSRSRSRSRSRSRSPRRSRSRSRKRSRSLSPKRSRSRSPRHSRSRSKSRSRSRSKSRSKSRSRSASPRKSASRSRSQSPAKEEHMAENGDKSPERDQNNEQEGEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQE0</accession>
    <name>A0A6P8HQE0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-1 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116293961</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557323.1">
        <property type="nucleotide sequence ID" value="XM_031701463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQE0"/>
    <dbReference type="GeneID" id="116293961"/>
    <dbReference type="KEGG" id="aten:116293961"/>
    <dbReference type="InParanoid" id="A0A6P8HQE0"/>
    <dbReference type="OrthoDB" id="5972537at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="36"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031557323.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35930" checksum="57A60B33CFA4BA80" modified="2020-12-02" version="1">MNETLNLTETNAKLVSSRFLPFAIISFILATGAAIGNLMLVTAIYKNPFRNLRTNSSLLVTNLALCDFIVGAVGGYGMFSYELFLYYGSFLSENVVNGIAATSGLAVVCGVGTVVVMAFDRYLAVKSPFSYTSKVTKYRIKGVLIVIWTYTFVINTIFFVAIPKNLGCFLSSHLHITIPACILSLTYIKMLQQVQKQNKQWKTNPRRVNVARQLSIRNIIERERKLTSAIKLLMAFFLLSFLPVYITMNIQYFWKHRTRLTWLRTFLEVSLLIVISNSFINPIIYALRVPKYRKAFRHAMGLRDNIVNIMMSAVGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQF2</accession>
    <name>A0A6P8HQF2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558604.1">
        <property type="nucleotide sequence ID" value="XM_031702744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQF2"/>
    <dbReference type="FunCoup" id="A0A6P8HQF2">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="GeneID" id="116295045"/>
    <dbReference type="KEGG" id="aten:116295045"/>
    <dbReference type="InParanoid" id="A0A6P8HQF2"/>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21453">
        <property type="entry name" value="DLC-like_DNAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000002">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 12" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558604.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12351" checksum="3FBFF743C327A9B3" modified="2020-12-02" version="1">MTESTEATGTQEAGYDYKRLHSFPLIRYSDMNDEMRTEAMELCVTACEKFSSNNETAAKMIKESMDKKFGASWHAIVGEGYGFEITHEVKNLLYMFFGGSMAVCVWKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR10</accession>
    <name>A0A6P8HR10_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558011.1">
        <property type="nucleotide sequence ID" value="XM_031702151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294527"/>
    <dbReference type="KEGG" id="aten:116294527"/>
    <dbReference type="InParanoid" id="A0A6P8HR10"/>
    <dbReference type="OrthoDB" id="5988101at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031558011.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13676" checksum="9F5B3EA0F3E4DC46" modified="2020-12-02" version="1">MRDKYTTVGVILGLSIIQNGPLPRFLSLEILEEVFGNENLGPCLQELXDGLKKTGIHQVGSQLPLFLXILKPGPPSILTVRKLISLLEPLFSESGSNRRAQENAVYGQFVKYLREAAMEEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT24</accession>
    <name>A0A6P8HT24_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116295029</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116295029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558586.1">
        <property type="nucleotide sequence ID" value="XM_031702726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295029"/>
    <dbReference type="KEGG" id="aten:116295029"/>
    <dbReference type="InParanoid" id="A0A6P8HT24"/>
    <dbReference type="OrthoDB" id="5966854at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF36">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031558586.1"/>
        </source>
    </evidence>
    <sequence length="745" mass="86339" checksum="687BD9E3D9D89E47" modified="2020-12-02" version="1">MNLQDLTAKYLIKIKEGNKLTNKAMQNIVTSTSKLFHVAFNQLKRKIECSIEEAGLEVEDIPGISDAFDEVCDPFDQLLTTWXQSKYXQSHSQYVGPEKKILGKTRKIVKRNXKKQILEIEDTFYYIPILDTLQVQIRSPSYLEFILRGPEKSNVPEELRDFCNGTFISEHPMFGSDDQALQILMYYDDVNVVNPMNNRIHQLGFLYYQLANLPPQYRSKLKSIHLFSICKKEHIKKYGLNIILQPFVEDLRSLGIDEGYPFEVDGGVIHLRGGLLATLADTPASQAAGGFKESVGGARRKCRHCMATFEQIQEFFLEENFDLRCKDEHERQVKRMENAPSKYLASYYSKYYGINTKAKLMEAPYFDVCQQLXQDLMHIFLEGILAYHMKHMLKYFISDSETDKITLDLLNKEIXLFPLGYSHKQDRPVHVKDSDIDIKASTNLGQSASQMYLLAFILPFIMAKHIDIQDSVHWDCYMSLIEIVVICFSSSITTQSVVYLKSAIKKYLQTFKDLYDARITPKMHYLVHLPSMILKFGPLIRSWCMXFEAKHSYFKDIARITKNFRNLPHSLSTRHQCMELADSLTLDDETDPCPLFXNDCDMGTIKPIRDHDSTAYAWQCIQNFYDIHGQCNIRIAEIFLVDSVRVYGTLYKPGANTFLLISKDFQNPEFGRLIKLWYVENLGVFFVLQKVDMISYSRYINGFEIEEPNLPQGYIIIAANDLPSPRVHHAYKFNDKSYIIKRDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT45</accession>
    <name>A0A6P8HT45_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC116292601</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116292601</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555807.1">
        <property type="nucleotide sequence ID" value="XM_031699947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292601"/>
    <dbReference type="KEGG" id="aten:116292601"/>
    <dbReference type="InParanoid" id="A0A6P8HT45"/>
    <dbReference type="OrthoDB" id="5989897at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028085763" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="452"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="854"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1081"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1370"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1383"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1401"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1417"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1446"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1467"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1496"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1523"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1539"/>
            <end position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031555807.1"/>
        </source>
    </evidence>
    <sequence length="1560" mass="179590" checksum="11C278A008F704BD" modified="2020-12-02" version="1">MTSLWLQSLLITCHLICVAIATKTLYIGGLFDFNANDAQRIISASQAAIQEIKSNLFLXGYNLELLVNDTREXDFTSASGVYNYLNSGPKKIMLLGPADNDIAKAIAHHAGAPSYGVLQFSYGTNDLYLSNYRGLYPYFFRTSISMATFDDLRIAFLKFYGWTEIGIVYGDSINEAKLSNNLKTRIESQSSTKVIAEIRLQANDPERAVRTIQDKNIHVIIGLFPLDIAARRLFCQAHRHALYGPHYIWILQMARNNXWWNPRPGEDIGGCQSIEMTCQIRNYFSVKPANEDYESSNIFSHSKKDTSTVKNNLRSEGNVTTVDDVMMYAYDAVWSIAHVLKNSNGTLGKPLENVTYGDTSTTSVFYREALKLDFGSPKLEKVRFYENGDRKFDMSVEQVVIKDENSNPVSEDAGTYSLTSGLYTEGKVSWPANTPYKTITETRDTRYIHRALFGAMIFLACLGILYALVCFIVVVVFRKQSIIWNSSPIINIIIILGCILNYITIILYAFDWTTTANTASFCRARAWTFAIGFTLSVGGLVAKLWIAYCVLSERFVRRWRNILIWMLAIILFLFILDLIIXGCWEGLDPLYATMETYKEQEEYKCFQPITDKTFNAYYYTVEHCTCRTPLAWLLIILILKFLVVIFGVFLAWQTRKLYIKSLNDTQYCAFCLFVVFFFVVFGVLIALLTTGFPNVFFSIVGIFLFLCTTIILGLLFIHKLARVVCKPRRGKRILVTGADSDTESTSSAKNCXCCGLSGACCIACCGCFPCCNMFLCCRSCCLGSKIHPSESSSDDKTEFYIAGHAQDKEGQIAYLLRKIHERDEELARLRPKHTCTSMWTQTNEDDMEEYLKREDGDGSSMESDNSEGSLDSSGKRRKRKXNKFKIYNHGADYSHVQSKVDTGVTXSPAKSPKTKRAHDEKYYLGVWKSNGGKPSDEEITKLQAQLKERDKEIEKLRNEKEVQTSVVIHQPNSLSNKVEIVNEQTPDTHEKQCQTDDSXLYIEQSPRDKPNEVVVVMETPVKKEESPREKPNDVIVVMETPVKTXSSPSKKPAKGKKNAKTEPKENVTVVEVKSKKKKKKKEAEPVVKSPDEWLFGKSDDGKEKQVEKKDVNVIVVAQTAVEEEKKDEPVIEEDKKTTVVFIRPEESKKKEEDKRQSHDGSVTNVIIVRPDDAQGNEENKDDEEKKKKEEDETREEEKKRREEEQRIEEEKRQDEMRKGEEKRKEEEKQKEEEKQKEEEKRKMEEKLKEEEERKEEEKRKEDEKRKEEEKRQEEERLEEEKRKEQELKEEEERKRKEEPERKQEEERKRQEEEMKKEEEEREKERKEQEEKQKEEEKXIDKPNEDIDDEETIPIRPPQNTPASVDGPQEEDNKKDDQKNKDDAIEEEGDREPEKDDDDNEREGGDDKDDDKVNGNDDKDDDKDDNENEDYDDYDASGTDDGDGDDNDTKNEEAPSDQKGDKEDKKNSTKPKRKPKKPIGGKLNWNAASKIDTSSGYKKKPRSKIKSYKVDYSHVKSKYSYGVTKKDQDEKKEKEEKEKEKKKKASIKGKRWNPNSTNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTF6</accession>
    <name>A0A6P8HTF6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear RNA export factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555922.1">
        <property type="nucleotide sequence ID" value="XM_031700062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTF6"/>
    <dbReference type="FunCoup" id="A0A6P8HTF6">
        <property type="interactions" value="2804"/>
    </dbReference>
    <dbReference type="GeneID" id="116292710"/>
    <dbReference type="KEGG" id="aten:116292710"/>
    <dbReference type="InParanoid" id="A0A6P8HTF6"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000004">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000384">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015245">
        <property type="entry name" value="Tap_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09162">
        <property type="entry name" value="Tap-RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="10">
        <location>
            <begin position="428"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="11">
        <location>
            <begin position="642"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555922.1"/>
        </source>
    </evidence>
    <sequence length="697" mass="77696" checksum="CE395918246C332F" modified="2020-12-02" version="1">MAGLFGKAMKDASLSVTTTREGSRTFDQDNQDSSSNSNRGGYRGRSQGRGQKRGRGRGNYWRPRGRGGRGRANPQNPTPRSYLIDEEDDESMGDEEDNATSFSRYTPYGTRPPSRRGFQNDRGNNRGTGGIKRWLGNQPQGKSDWYKVAIVKGKQHDKDWLLRKLQNASEEAFQPVEFHYKGDTAMFFVEGSSAADALKKVSHQITVKDGSKLTLTVRQSERPFMTNHSGKEGSAFSGTDSSQWNAETEQALKECLSNRYNMETKTMDLSDLFHDEVLKANNVQGSLYRAPVANAILKLIGENCPDMQGLDMSDNRLYNLEAMKDLPTYAPSIQHLKLSNNQMRNIEELDKLKGLTGVVTLFLNGNPFCDKFEGKESSYISAVRSRFPKVLNLDGVEHAPPIGFDLATTTALPKVQGSYLVDPEIKKLLLSFLEQYFRIYDSNDRQPLLEAYHDQAIFSMSVNPGSFNREKGPRGPSLGEYMKSSRNMIRRKEQDVRASLIKHNRLSVVAMLNELPPTTHELSSFVVDVSLAIPTCLHFSIRGFFMEGNKTMRSFTRVFVALPAAGGKSLKIVNDELHVRGPALPQIQAFKKQQESITATSTLQVPAAVPTIPTTLPTIVTVPTLTPSTSLTTLPIPSGLTPEQQQMILQFSRESRMNAEWSKKCLADNGWDYQKSAECFTSLNNQGLIPPGAFIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTK6</accession>
    <name>A0A6P8HTK6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="17">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116295015</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="17"/>
    <dbReference type="RefSeq" id="XP_031558573.1">
        <property type="nucleotide sequence ID" value="XM_031702713.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HTK6">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116295015"/>
    <dbReference type="InParanoid" id="A0A6P8HTK6"/>
    <dbReference type="OrthoDB" id="2413561at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000200">
        <property type="entry name" value="inactive tyrosine-protein kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000189">
        <property type="entry name" value="Neogenin isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="2 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028318776" description="Tyrosine-protein kinase receptor" evidence="19">
        <location>
            <begin position="35"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="229"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="335"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="410"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="517"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="592"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="771"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="901"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="805"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="810"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="851"/>
            <end position="857"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="905"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="23">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="23">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031558573.1"/>
        </source>
    </evidence>
    <sequence length="1040" mass="115677" checksum="3E43D37B344C8115" modified="2020-12-02" version="1">MESVALSRLWPQQISIFFFCFCLVLLGSLKESQAQISFTEEPKATKAIAGKPVDLNCKATAPRKIRYVWFFDDSRIAPDGSRLIIRADGTLHIANVDTTDAGNYQCRASYRDLTAGKRITKKSQIVDLTVYDLCSSITLTSSPSGPVFPTGSTFTLKCKCPSTPSATTVWTKDSTPVTSGGQITLNGNKLIIKNPTTSDSGKYECSVSNNAGTRNSSAIDVQFMKLVEPTFDVKPKGVTEAVDQSVLLDCKASGKPQPTIQWYFETQNTALSNTSIYTVFSNGSLLIKKIGNDKFGNYKCEAKNIANSKTVVAAVSKAYIKNIRFRRDIEYAEVGKEFLLDCKAPGDPKPSVTWLNADGGPLPAXYDVKDAMTLRNKMVKVTDSANFTCTAKNVAGNRSSDVQVIASVYPKFTTNPQDMLVEENKKVVLKCAAKSRPPSRISWRKYNERVLADGSNTIINEGTLTINKVEHMDSGMYQCVARHPSSKSESSRRANLTVLAAVRLADFHKIDHKFKMGTNDSKIYCFFTGHPPISVTWKKIGSKKFPKTTVPNGEQLSFKDMKMSDGGIYSCTGSNAFSSVTALVNVSVYIYPEFVLKPKNTTAIIEESVWLHCNASGYPKPKISWGREKHGGDKLNKERFHKFENGTLHIENIQPGDQGRYYCIAANKASFRQITISLWVIKPPAAVAYTTNTMGRTIGIAVGCAVAYIVLVVGLMIYCKSRRARQQKREQLTVVAAHDLENCDENPEMALQPINGKLGSYHKMEFPRHDLEALRTLGNGSYGRAFLARASGIKDGERETMVVVKSLIAKDDIIKEDFRREMSALVDMDNPHVLSLLGVCREMDPLYMIFESLEKGDLKQYLLSCYDNGRSTINSSQKLSMCSDIVSGMAYLAANNFIHKDVAARNCMVTKDLQVKIGFLSLSYDLYSSEYYRFNNILIPLRWMAPEAIFNDDFTEKSDVWSFGVVSWEIYTLGRTPYENRSDEEVLKCVKGDLRLSKPDNCPDSVASVMTKCWEDDPDNRPTFEKIYAEISEVAVDSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTN5</accession>
    <name>A0A6P8HTN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Betaine--homocysteine S-methyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116295943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559764.1">
        <property type="nucleotide sequence ID" value="XM_031703904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTN5"/>
    <dbReference type="GeneID" id="116295943"/>
    <dbReference type="KEGG" id="aten:116295943"/>
    <dbReference type="InParanoid" id="A0A6P8HTN5"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000003">
        <property type="entry name" value="Betaine--homocysteine S-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051524">
        <property type="entry name" value="BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120:SF1">
        <property type="entry name" value="HCY-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="8">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559764.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42207" checksum="A7367CF2C6D21D73" modified="2020-12-02" version="1">MASLPKKKKYNMSEKRGILERLDAGEVIIGDGGFTAALEKRGYVMAGKWTPECTVENPEAVRQLHREFLRAGADVMQAFTYSMQDEPVEIDGKTVSWDEINDAACKLAKEVAEEGPYALCSGSLCETVQAYRSGKVPKEVIKEKFKKQVDIFVKNGVDLLIAEYISHVGEAELMVEVMKASGKPTAVTLAIGKDGDRHGVLPGECALRLARAGADIIGVNCRFDPERSLEVMKEMQHALKKEGIKMHYMVQPLGFWTPDANALGFIGLAEFPFAMDPRALTRWDCHKFARKAYDMGIRYIGGCCGFEPHHIRALAEELSPERGRLPLGTKKHGLWGESLNNYTVPHLKVKANRAFWENLQPATGRPYSAPLSEPAGEWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUV8</accession>
    <name>A0A6P8HUV8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">[histone H3]-dimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="14">1.14.11.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116296338</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60188"/>
            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the JHDM2 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.65" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031560204.1">
        <property type="nucleotide sequence ID" value="XM_031704344.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUV8">
        <property type="interactions" value="2641"/>
    </dbReference>
    <dbReference type="GeneID" id="116296338"/>
    <dbReference type="KEGG" id="aten:116296338"/>
    <dbReference type="InParanoid" id="A0A6P8HUV8"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140683">
        <property type="term" value="F:histone H3K9me/H3K9me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000004">
        <property type="entry name" value="Putative lysine-specific demethylase 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054294">
        <property type="entry name" value="DUF7030"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054503">
        <property type="entry name" value="KDM3AB_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054504">
        <property type="entry name" value="PWWP_KDM3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22989">
        <property type="entry name" value="DUF7030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22988">
        <property type="entry name" value="PWWP_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22987">
        <property type="entry name" value="Tudor_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="18">
        <location>
            <begin position="2298"/>
            <end position="2503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="296"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="398"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="745"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="880"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1038"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1243"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1281"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1409"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1902"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1947"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2022"/>
            <end position="2045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2061"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2110"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="574"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="915"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1243"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1285"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1295"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1330"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1359"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1415"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1445"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1461"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1471"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1493"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1545"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1574"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1590"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1905"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1952"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1963"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1987"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2079"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2110"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2128"/>
            <end position="2142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031560204.1"/>
        </source>
    </evidence>
    <sequence length="2544" mass="288861" checksum="125FC63883153D33" modified="2020-12-02" version="1">MYPFRKELVGKRFLCVRDTRSNSSRPNSRSNRLSNPLDYEWKCGIIRACTEQDSSHQDQKVLVEYDNEDWTTREWLHVYSDAWKLFLVEKDMVWAQRYDPNYPRRSLLWPALTFYPLVDKHGLDENQSIGVEFLGDHVRAFCQTNEMRPYQEDDGLQPALRNNSKVLEELVNWQTLQKSQGILIYGPFTLTGFRVQVYREKCRQWFSAVITSHDLITREMDVMDDTVLQTHRINPRLVMVLLLANGVELDSMLRGDLVRVLPVRRNRQSQVVITSSYTSTTPSCTTGNSMWQFLNDMCRDSPSNPPAQTSTSTYQTQALRSPPVNMSTAAKNTSSGEERRASEASRNNKNLASRDPKPTTDKEVASLESKSGTYDGMEQDRKSMKHGSISLFQHEHENSTKNLGLQKPNTSPVRTPFPHSSPLRPPIPSPIHYQSPYSSLENLSNSSSSPVQNRSPQRPFGSPPKSSPGPSSGTLLRASPLKSSRSPPIILDHKQPHFTPPKRQFTPPSSSSFSPLRSNKLSPVLSSPSLHGLINLQNSGLSPGHSHDPHQLMGAFACSPRHSPPNVLTSQLYALQLQQQRQLQDQQRQQLQHDQILSQFHMQMNQLQQMADQLKSCQQGMLSLEQREMLNLYYNQIMSQYQQASLIKYHSAASQDSTILSTDQQMQMLREQMQFXFLSDQQKQDSYKLLHTVPEKDQFQSMLSHMQQYSNVYTELSHKRSNDKAQNQEEDSIKDHVARLKKFIPNKQXELKANSQTASTSPSLGTKPKKDTVMSIPNTSSSSLTCLASSKESTISKAAAVSILPLMQSVEKDHNKTDDQKVVDALVKKPSVSECPSTSTVETNKSSIPLMATGQENISSSILSQTKNNTYKLEDQFSTQEIKKSKVSPKKEDDPFGFNSIGDDVNKKPSYATVTNSSDNSSNKLSTTSSSKNKSKGKKTAVLSTLADHSVKHSHNEAVDETGAAKSEATNSRESVIKYVVNKSEPLVTSLNIPNKETSTATLDTETLPFSVDQLLEFHKTSAQAAVKVFERTNEVAEPKLSDTNKKQGKKRKKDRTLEDRDNDKIPIKKSTKSAKQSKKSKQKVDESKQELSGCLENEPTLQTSDLLSKADDHDCKKQKTGYQKSLENNSSKPLCSFFQNINENEMKCKDGLKEQEKEILCTENISRNADKMQDWRLMKQLSATDTVVSSYNSTKSAVPVNFVADQAVKTVTTVSRASEPVLASTLCGTEYVVEQIETSSEAASGDSATFKSEVTRKRKKSRKVLENELVLDQDKLKEEENEKLKKKLSKKCHQMSEKVDXKEIPEIVDQEEQERFVSESKKKKKKKKKEEPSEDSKGKEKKDKDTKKKKSKKMENGILTTDSKLNDTNRMGEMPNEIEKALLQCDNQEMDGQKDDLRKHFGEGKYVEAPTEVRNQESKKIPDIIDPIKAESQKSFNIKKSQKIKNDKVVEGNKDEKMKKEKKVKKRKTKEPTDEMIKDTRTAEKPAVTKNDSCRGEDIKRDVXDSNATAEKKDKNHQENDKNDEEIAERKKIDTETAPNNHTVNDEKMESDNSMKVETEIKEEEKSEEVKKKTTGKKKNLEKKKSIKRKQDTTSEELEVHSKKKKKXKEPAEEYFLQNSGCLAFSKLPRCRDCRDKEEKPAMNSQVCCRFTLFRRLKKKKRSDKVQVAGFLSPENAEPDDFEPWVAHQEVIDILSKNEALYILNNVAXEFCSLVKEEKRARTLVADGSFVAYKRAVTGLREMCDACATTIFNIHWVCQKCGFGVCSDCYELRIKEKTKTEKKSFEFKWFNCMPGLTHQPKNLTIAQIIPGEVLTDLSKELHCIRSQWDSGRKCPCNYEQLNGDIVTQYDNALIKKDDSEPHNVVIQSGNACIKKESDSEPASVTQYSNQCIKKIPGEIQSENAHTKEEDNKHEIKQETKEQNDGSVETVTKKTIMERVRERLREKIKAQETGSTETQVQEDQMEPESDLEETSGVYIAESDLEETSVKTSEECNENTRKTNEMVDDKAAVNMSSGLSLLMSYDSSSEDSPPTTPNKPSSSGSSFDFNLGLLAFVASTEQEKRSSDVSNADQQVQEQEQEKQLEKVEDSGEVKEKLEKNKMLDWFKKAEEEHKKKPENDESCEETKTSAGESTSSAVTMESDTSRDQHMLDTPRITEECPAPFSLLCNGRLLRLHKPHHPGNQNAFAKRWKEGKPVLVSGIDTLLDRNVWSPQSFENEFGDELADVVNCRTGKTLENFSVGAFWKGFESIEDRIKDSNGEPMLLKLKDWPPAADFSEKLPSRFNNLMDHIPLPEYTRRDGSRNLASRLPNFFVKPDLGPKMYNAYGSAAFPTEGTTNLHIDMSDAVNIMVYVGVPREKCAGEQERLDAIRAVDVACDEIQQQRVRRETARIGALWHIFEVHDADKIREFLREIAKERKLKYPAHHDPIHDQCFYLDLEMRTRLKKEYNVEGYAICQCLGDGVFIPAGAPHQVRNLYSCIKIAEDFVSPERIGQCFKTTQEFRHLTDKHTNHEDKLQIKNIIYHAVKDAVYTLKHHESQQTNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVV3</accession>
    <name>A0A6P8HVV3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetylcholinesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116296631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560539.1">
        <property type="nucleotide sequence ID" value="XM_031704679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVV3"/>
    <dbReference type="GeneID" id="116296631"/>
    <dbReference type="KEGG" id="aten:116296631"/>
    <dbReference type="InParanoid" id="A0A6P8HVV3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="36"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031560539.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="70240" checksum="9A2ABF04205EFBAD" modified="2020-12-02" version="1">MGHVNRIPTAFRRFKCAFNLVMLCWQLHFYAANTVLITTKYGTLRGLKVPFSSNSGPIKSINTFLGIPFASPPVGDLRLKPPVDPVSWEPNIYDATHFRNVCMQEPSQLLTEYRKVWRSFDPKRNIAEDCLYLNVFSPDSRASYSVMVYIHGGGFMLGSSILSPGFQLALKGVVVVTIQYRLGPFGFMSSGDSEAPGNIGLLDQVQALRWVRENIEDFYGNPHEVTLFGLSAGAVSVSLHLLSPVSLSFFHRAACESGVDLAPWAVQNTEKIVNHTRAAAERLGCHQEESQSLLDCLRNVHDPWEFLNASLDATKSNGLEKSYFGPIVDGNFLADKPSVLRKKGLFGRIPLIAGITSDEYSLFLRDEIKNLFNISNLSRGIDKNIFISYCQKFAHALQANTRYRALLYDALLFEYSSWQAQSNQSFLQYLIDLTSDYYLWAPTNAALVAHSEYAPAYMFVFNHRSSLGHTPLWAGVPHGSTFSYVLGIAMKNTSPKHRLVYDVTDYDVSNAMVTMWTNFAKDSNPTPSKVSGVTWEPFTKANQVYMKLDGKPVAKMAKNYQAPRAAFWNYYYHKLMKGSPKCSSAHATPPSNEVPLFKGSVTTWYLVVMTIFLLEYYFELQFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWF7</accession>
    <name>A0A6P8HWF7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556912.1">
        <property type="nucleotide sequence ID" value="XM_031701052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWF7"/>
    <dbReference type="GeneID" id="116293603"/>
    <dbReference type="KEGG" id="aten:116293603"/>
    <dbReference type="InParanoid" id="A0A6P8HWF7"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF466">
        <property type="entry name" value="RING CANAL KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556912.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="64166" checksum="DC77629FB5310449" modified="2020-12-02" version="1">MADDIAKQETQVLIYKDSFHPCHVLETLRSLYQRQKMCDVVVVVEKEEIFSHRLILAANSSYFYSMFTNGMSETNQTRITLKEVDSEAVRQLIDFCYTSTIEITEENVQNLLSVANLLQFTTIIETCCSFLKNQLHPSNCLGIGNFADHHDCTELKLAALNYAEKKFLEVAKTDEFLLATYDQISSILKSDSLNVVSEKDVFDAVLLWTRHDLGERKEHLPSLLKYIRLPLLAPKILVDCIESDDLVQESDICMRIISQAKNFHLLPERRDKMQVPSTPRQMDHGAMMYVVGGEIHNQVFNTVQRYNFETEKWDFLPNMHQRRDGVGVAHHAGRIYAAGGCDGDVALSSVECFDAATQKWSFVQPMACGRHAFSLVELDGWLYAAGGSDFSGSEYNTVERYDPVRDMWNSVTPMSTMREGISMVTLDGALYAIGGDSGLTILNSMERYDPRIGQWSACIPMGYRRRYFGAAILKKKIMVVGGSDNDEDHNSFECYDPRMNRWMSLPPLSMRRESPAAVVTDDQLLAIGGAFMNVETDSIEKYDPLSNKWDKFQPLPGPLEGMGVIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXK5</accession>
    <name>A0A6P8HXK5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297091</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561109.1">
        <property type="nucleotide sequence ID" value="XM_031705249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXK5"/>
    <dbReference type="GeneID" id="116297091"/>
    <dbReference type="KEGG" id="aten:116297091"/>
    <dbReference type="InParanoid" id="A0A6P8HXK5"/>
    <dbReference type="OrthoDB" id="5949486at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561109.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28875" checksum="D686B5E84DA2C206" modified="2020-12-02" version="1">MIQSLANTLQGHNIQWYTDNKNVVSLIHRGSMNPELQAVAEQITDACSVNSISVNPVWVPRQQNQLADYVSKLNDVDDWGISMPIYKWLNNMWGPFTIDRFASWYNTKCTRFNSRFWNPGCENVDAFAQNWGSENNWVVSPPSQIIRAWRHFYICKAKGAMIVPLWKGAVFWPCLCPDGTHLSKHITDWVGIPDYHVPATVPGRCFNTLFKGTKLSFRLIAVFIAYSRPITRTNDRGFCMSFNGICDNCVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY68</accession>
    <name>A0A6P8HY68_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein broad-minded</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBC1 domain family member 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116296442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560318.1">
        <property type="nucleotide sequence ID" value="XM_031704458.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HY68">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="GeneID" id="116296442"/>
    <dbReference type="KEGG" id="aten:116296442"/>
    <dbReference type="InParanoid" id="A0A6P8HY68"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000031">
        <property type="entry name" value="TBC1 domain family, member 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055392">
        <property type="entry name" value="BROMI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032735">
        <property type="entry name" value="BROMI_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055391">
        <property type="entry name" value="BROMI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF3">
        <property type="entry name" value="PROTEIN BROAD-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14961">
        <property type="entry name" value="BROMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23440">
        <property type="entry name" value="BROMI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23431">
        <property type="entry name" value="BROMI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BROMI N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI middle region" evidence="10">
        <location>
            <begin position="178"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="BROMI C-terminal Rab TBC-like" evidence="12">
        <location>
            <begin position="883"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031560318.1"/>
        </source>
    </evidence>
    <sequence length="1320" mass="150460" checksum="D89FA6EC9D050413" modified="2020-12-02" version="1">MENTIDERQESFVASLDQFFTSIEPVIKEASSIEAAEDILTNLETTDENFHRYDFVRTLRSRIDEVLGPLIDMKLESLSGESDSNSLLSQIADEIQSSQDFISLQQSVLGDTKEAVNFLIQKYSNPLQRGASDFDFSEYKARQQNPKNSYDLSDEESSLSSSIDQVGYMFMSQEKSGKIAENLHPLQPVHVRSEALSALAQVPQSDVITSEHWVAIRKGLLAALADEDEHLSEKSLKFHARLFLSSTSHATREIYTCLAEHLWLHFSSKTDSMGRLEDGLDVLTKSNARLIRRFRLLNEFQHEVPSYWIRYSERFLEEILESTFTLIDASSIVHVSDSPDVQYITPLYYIALMDPMANWFKKWMHGNYSRTEVVKQLKEHTNLVRRTDFIVPFSYSVIYSLIHPSIHLTVCLPIHPSIHPPDYAKSGLYYSARDLEFLYFVHSLSVLGRLLLYNDGRALFPIDLPKRQETVTVTDLLVVFIKIMCIPMPRSITKAVMGGTIVPGELVAEVLQEIASNSEASRKCLCKDAITSNLLAPVQNILDGFMDLDGIEDADSENVLLLISEVLATIAATDSGRLQLLYGESQERWQRSRFSPAHTIAGFAKKALSNRLCCSLSNDVIGGFIFVCRVLWTTCEGLIVLNQYALHDKVAEAWNKAIEMSPSTPTNSDDIPEPLETQPEDIQKTESLAWESSLLDNLLNFAGTPKGVLLLQQTGMMDQCVGYMYERYTKKLQVSKCEKFGYGVMVSQFAATAPGIVALEKKGYLKHLVQDVWTVFEGFHDRRMQPMIKHIDTIDSKSYNKSLNNILSVLSAFCAVYEVLSDVNRPSTSTSEVEEITAVATGNPTTLAELIDRLIMIDSDLKISALFNYEQSHHFGLRILSVLCSCLDTFLFLESTYHFTDLLLQAQLDKRLENGKDYIIDMCSVEINHILVKSYWVGGPSERILPENTLTEEQNNPYPWPLFSSFPPPKDYVVQDHVVMTNAFQEDDKLLEFLEKDKPSPTESIEWLEKFRELFCSTIKKGHFKCKVKVIKLLLESVCHALTNVPEESIFPLIEFSVGEMSLKNTELSSIESLGAKLVVRYGLNLKILQSSMDGTEDLCHLLKYAKFFMRSQQKIPDSTLRTLSVEYPGHDWFVSTIFLMFGGNPDESREFLFKFSSLVCSGYLWIRRLHASVHLPTSLTVSGIPPLYSSTCHNVELILQAEVPLVYSAFRMSGYTPSQICQHWLRQCFWNYLPWDHICLYVCVCLILGIDYQVYFCIAILKHLQQEILEYTQQQKLLVMLKEEPIRNFRLQXHLDFMQDLEKRYRLTILSDLQNITRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYB1</accession>
    <name>A0A6P8HYB1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIT domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561354.1">
        <property type="nucleotide sequence ID" value="XM_031705494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYB1"/>
    <dbReference type="FunCoup" id="A0A6P8HYB1">
        <property type="interactions" value="981"/>
    </dbReference>
    <dbReference type="GeneID" id="116297287"/>
    <dbReference type="KEGG" id="aten:116297287"/>
    <dbReference type="InParanoid" id="A0A6P8HYB1"/>
    <dbReference type="OrthoDB" id="19553at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052817">
        <property type="entry name" value="MIT_domain_contain_protein1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222:SF1">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561354.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27511" checksum="3460DEFCE7EB9CC2" modified="2020-12-02" version="1">MTLEAAISVLKRAVQLDEDKSFSEALVCYQEGMSLLMSELKETKDDVIKKRYRDQMNAYLDRATKLKEFVQEKKTTGEYHEQIKIKNGQVGYGYAKIFGPYLDKSVTEVVVEDAYIRSTHQIYNLLRLCELLVLKGSVQVIKLFTGQDDNAEKRRLQNDGLQELVKSLKKYSINLQVTYTNTLHDREIRFDNGWVIKIGRGLDYFKPPSGKFCIGYCDYNLRECHQTDIDIYFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYF2</accession>
    <name>A0A6P8HYF2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294274</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557695.1">
        <property type="nucleotide sequence ID" value="XM_031701835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294274"/>
    <dbReference type="KEGG" id="aten:116294274"/>
    <dbReference type="InParanoid" id="A0A6P8HYF2"/>
    <dbReference type="OrthoDB" id="5962291at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557695.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31982" checksum="6455059D36101F91" modified="2020-12-02" version="1">MAQLTKEIEHMPRDMAIFSRCLRSLYAEEAVGTNSGAAVKFRKLRDDTRKDAMVYLIVVLPTCFKFLVSISKSIENYEALEYEEWCDKLEDILVKTTGYKQLCERITKMHENILVPLKKRQDQANLVVQELKDLQLEFERKKKELEKSADEKSMWAIVLFFIPIVNLIATPVLLEESADDTAKSVAHGAQAKVQEAAALTIQVTLIPALKSFIDGLHXAAGFFKVMEVELGKFQGKAEKSKETKKKLYYKIMKAEAKKIDSVCQRSYSVIPVVTSDLQAIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZE2</accession>
    <name>A0A6P8HZE2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116296821</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560783.1">
        <property type="nucleotide sequence ID" value="XM_031704923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZE2"/>
    <dbReference type="GeneID" id="116296821"/>
    <dbReference type="KEGG" id="aten:116296821"/>
    <dbReference type="InParanoid" id="A0A6P8HZE2"/>
    <dbReference type="OrthoDB" id="5966876at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47457:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47457">
        <property type="entry name" value="OS05G0345500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="486"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560783.1"/>
        </source>
    </evidence>
    <sequence length="745" mass="87379" checksum="114490918DB8AE34" modified="2020-12-02" version="1">MNDEHRNLLRRHHLLFQKDLEPRKLLAHLVTVLDIRDEDEIKAQATRELQVDKMLDILPRRGPQAFRVFLDALEAVQPFLAVPLREEDEIEKRLTETRTELGRARSHSANLRNQLSCASSQLDTEKSKHGKTRKELDELKSIHQTLLSEIKKESQKLLSKVTELGVSNETLKQELQQEQLQKTNLESKVRDLEIFLENKNNEIANVREKELYMRVVMEKHKQEGSDAKTPSRKLSLEETKRHFRREILRRRAYSEKSSYEESIDKEPLEKFDEIIQEEDMYVHDEKILEIVHEREAMLKCFDEKLEEMNNELTLVKSEKDLAKLECTQLRVKLLALEEEATRSVEDRATSPITKSGADNLQCGECKTKTAEYDTLLLRMEKEMATYKEEIHKVTCRTNELTDKFEREKKSLEIEIESLKKLYDTSKEDYKNLQNEMAEQHSKDIKDQCVIKTDLTAQIEIDKLVITRLKSELDKERESSKTFQKDNDKFKKKIKAEKKQLKQQLEQESKISTSKMKEKEAALIELRDSEKRNLEEIAKVRKITSELQNKCDQLGDELERWRSLPGRVFNFKKEFDRNGVIYTLGTNFNTTPFTNPASNNNCSIIVTRSSQGHGHPLDLLDLKKGSLSCTKDEENSWWRVDLGEDYTPFVTHYTLRHGRDNGLSVIRNWNLEGSRDGRTWKILRKHENDRTLKEPFPYFMGTWAVEGKIEAMRFFRIRQTGKNSSGRYALCLSGFEIYGILLFMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZK6</accession>
    <name>A0A6P8HZK6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558042.1">
        <property type="nucleotide sequence ID" value="XM_031702182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZK6"/>
    <dbReference type="GeneID" id="116294556"/>
    <dbReference type="KEGG" id="aten:116294556"/>
    <dbReference type="InParanoid" id="A0A6P8HZK6"/>
    <dbReference type="OrthoDB" id="5962355at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558042.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33798" checksum="EEFCEF63F0E0B527" modified="2020-12-02" version="1">MWERLRAMLDQKCSIRLMYVVILIFVGRLVCLIMYALWLGDCFLREFKMEAPCKDFTLYPEPKITSAVWLMIVSFTSFLLIFYVSRLSDFRGFKSIISKLLRKKYFYKLCVITILVVIYDSITIGAREFEVKTTLLYVAYIIEHITTVALMFRLNFVKNVPQNKLQYHAYKITLLLYSIENYVLYAFGTVVAAYKLVSVPTTCSPTPENQINTDCYDALAVTMLFLLLSVLALRLTVGEFFLTKFFEEFEDVPPSQAPPNLPNSPVTQRKEEEKEKRTGTEETILEKDNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I100</accession>
    <name>A0A6P8I100_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Heparan sulfate 2-O-sulfotransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116294987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558550.1">
        <property type="nucleotide sequence ID" value="XM_031702690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I100"/>
    <dbReference type="FunCoup" id="A0A6P8I100">
        <property type="interactions" value="1583"/>
    </dbReference>
    <dbReference type="GeneID" id="116294987"/>
    <dbReference type="KEGG" id="aten:116294987"/>
    <dbReference type="InParanoid" id="A0A6P8I100"/>
    <dbReference type="OrthoDB" id="10019582at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004394">
        <property type="term" value="F:heparan sulfate 2-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009101">
        <property type="term" value="P:glycoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001418">
        <property type="entry name" value="Heparan sulfate 2-o-sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF17">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558550.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43793" checksum="0B1A817CC89DB310" modified="2020-12-02" version="1">MFGRGLVNKLPVLIVLVVVGILELQILKISEIKNQPKSQGPIHEDHKNPIESKDVRNTVSEDDKDVDESETLTEGAKPSAMVGFDDYSIDDNAIIIYNRVPKTASTSFMGVVYDLCEQNSFHSIHLNITKNQHVLSVADQLRLANNITRWTDRLPALYHGHVEYINFRKLGVSKRIFYINIIRKPLDRLVSYYYFLRFGDTFRPYKRRSRRGDKETFDECVQEQHRDCKPERLWLQIPFFCGHAPQCQSPGNRWALEQAKRHLIEDYLLVGLTEELADFVMVLESVLPRFFKGATKVFLEGNKSHLRKTASKKPLEESTILHFQQNKIWKMENEFYEFAKKVFYTEKKRTMLQRNRDVVSSPVQFFYEKIRPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I188</accession>
    <name>A0A6P8I188_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 66 member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PQ-loop repeat-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561513.1">
        <property type="nucleotide sequence ID" value="XM_031705653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I188"/>
    <dbReference type="FunCoup" id="A0A6P8I188">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="GeneID" id="116297429"/>
    <dbReference type="KEGG" id="aten:116297429"/>
    <dbReference type="InParanoid" id="A0A6P8I188"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000008">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031561513.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28810" checksum="1DE57B8944137E8C" modified="2020-12-02" version="1">MPPNIVQQQQRPDTLTVMGLSVVNVISWISSAAMVFGGVVPYIPQYWDIWKSKNADGFSIHVCLALLIANILRILFWFGRQFETPLLLQSFIMIVAMLAMLQLCTKIKRETDLLGKRRSFLDFNVDHFWNWTHFSDYVLCLCIFVALSGYVTYLCLESFIYIETIGFLAVFTEALLGAPQFYQNHQKKSTIGMSVKMVVMWLSGDSFKTCYFIVKNAPIQFCICGMLQILIDISILIQVYTYSSEASRHMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2Z5</accession>
    <name>A0A6P8I2Z5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297743</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561886.1">
        <property type="nucleotide sequence ID" value="XM_031706026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2Z5"/>
    <dbReference type="GeneID" id="116297743"/>
    <dbReference type="KEGG" id="aten:116297743"/>
    <dbReference type="InParanoid" id="A0A6P8I2Z5"/>
    <dbReference type="OrthoDB" id="5989827at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561886.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36276" checksum="1E955B4C441D4844" modified="2020-12-02" version="1">YERLAHTSLMLLNCVPLALHGREEWRLVLDGNITCWVQWWQYVLIAYNIVFVIPFLLVLLVGTSKLERQKISALQFVAACFVPLPFLIYWMLRRCFRSDSDDDRRTPHQSPQGEEKRKALLGVLQGPFRPPDSQSRGASYWESILIGRRLVFLCLYSFISTPMLQMLLMTAVCIVILVHNIVVRPYKDQKAHLFGVIMLSMHVALAIINLCKSVLHTVGVTPTGPIEAQIKGLQLFEVALLGALPLIFVLLILLTLLSQITRVFVIVLRFFVLRSRGKVRALAINSDNDNRRPLLAYAGEQESLSYSTGSEVQEKDCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I400</accession>
    <name>A0A6P8I400_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295833</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559647.1">
        <property type="nucleotide sequence ID" value="XM_031703787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295833"/>
    <dbReference type="KEGG" id="aten:116295833"/>
    <dbReference type="InParanoid" id="A0A6P8I400"/>
    <dbReference type="OrthoDB" id="5979206at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="2">
        <location>
            <begin position="76"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559647.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24769" checksum="2BFFCF4D578A8401" modified="2020-12-02" version="1">MSDLESELSTNESIENEDSNDEDEINFNFESVFRPYEDEPLALGNDLAEEQVGDEVDGDGLTADTLRLRFEKIVPLQNWCSCGNCHDNHLVLRAEFRCCKEMAXCLGRFTFEGLNXQCILTHPDYQAMTNKTVLLQVGPLFTDKEGRRYRKQGHTENEFIKAVAYRWLIRWLCGYMGWENTRPLPACIYHDIRCKYPXNATKGYQSGQERAANNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I463</accession>
    <name>A0A6P8I463_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116298914</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563354.1">
        <property type="nucleotide sequence ID" value="XM_031707494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I463"/>
    <dbReference type="FunCoup" id="A0A6P8I463">
        <property type="interactions" value="2214"/>
    </dbReference>
    <dbReference type="GeneID" id="116298914"/>
    <dbReference type="KEGG" id="aten:116298914"/>
    <dbReference type="InParanoid" id="A0A6P8I463"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
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            <begin position="237"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4S4</accession>
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        <source>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_031563559.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55708" checksum="8DA2792C08CFEF9F" modified="2020-12-02" version="1">MASFDEKIERLLEDFEGFTHEQQNKLLKSLLLKCQPLQLRFLYSELKPLLSVDFVKNLPKEVTERIFSYMSAVTLCKVALCNRLWRERANHNPTWHKLCVQKGWEKFGEEQPLCIESSTVINRPTSPSKLPPLPAFHFTDEQSVLNPATCRWKTIYIRAFYLQQNWKLGRYTIAPILRGHKEPVNAIDSDGKVLVSGGSDNTVRVWDLKEYQCKHVLETPHTDSVRCVKLKDSLCVSGCSDGVIRVFDVKKGQCLRSLQGHSGGIEHMCFDGQTIVSAASDRTVRVWNVKTGKMLHTLTGHTDEILFMSMRXNHVITTSWDETIRVWDIDAGICLLTLRGHSEAVYCCQFDXKRIVSGGGDNLVIVWDASTADIQAKMTGHTGEVYCLVFNEHVIASGSSDSTVRLWTFQGRLLHTLYEHIGVVRCLRLKGDMLVSGGDRKKIVVWDTKTGSLLNVVHRNPTLLHVMWTDETKLITASPEKPGTITIINYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5I0</accession>
    <name>A0A6P8I5I0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296359</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031704372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5I0"/>
    <dbReference type="GeneID" id="116296359"/>
    <dbReference type="KEGG" id="aten:116296359"/>
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    <dbReference type="OrthoDB" id="10277929at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028416794" evidence="2">
        <location>
            <begin position="25"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560232.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24830" checksum="DE03AD051C94F9FF" modified="2020-12-02" version="1">MLSSSTHTFWLLLLKLFATKIVRCTIVGPTRLQDLVGNDVIFKWNTTDGREVLSAVWGLGNKQMPDPQFINVNTKNGKTISPSLPKTYTGRVDFVGNLSQGHAWFVIKNLTRNDTAEYIARISDGDVSELQSYSVLLSVKDRQDNFTAFVSKPTLPEEIVTVSSDYTNNTKNASSQTPRPPSSEATSITPHLLFTMFLVLIGQLIWLKGHLDENAPIFESPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I666</accession>
    <name>A0A6P8I666_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trace amine-associated receptor 7e-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116296348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560215.1">
        <property type="nucleotide sequence ID" value="XM_031704355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I666"/>
    <dbReference type="FunCoup" id="A0A6P8I666">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="GeneID" id="116296348"/>
    <dbReference type="KEGG" id="aten:116296348"/>
    <dbReference type="InParanoid" id="A0A6P8I666"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031560215.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37669" checksum="4C690219A6AA7742" modified="2020-12-02" version="1">MATEENQLNAAAPESNLPRYLSLTMGIFCLSLSIITVSFNGILCTALYKNPLKCFGTPNSFLLLNLAISDFLTGLIVDVLYSAYFLAAFRHREILSLYEAAATASFITVNVSTCTIVLLSIDRFIAVCKPLSYKFLMTRDRVIVCITCSWVYCIGFSIIPHVGVPKWLYYLIDAHLHITAPLVLLTFTFVKIQKTFKNNALNNDFHEMRCKQEKILVQTILMILILAIICLLPYYITVHIDFYCQYWTRCPVSTIYDWFGWLSEPVEFINSCINPVLNAYRLPKYNKSIKVTLGLTKLDEEGKLQAPCPASASQVMIPAPSPTSVKHLSVNTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9R3</accession>
    <name>A0A6P8I9R3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein PF11_0207-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563931.1">
        <property type="nucleotide sequence ID" value="XM_031708071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299415"/>
    <dbReference type="KEGG" id="aten:116299415"/>
    <dbReference type="InParanoid" id="A0A6P8I9R3"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563931.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32995" checksum="92E4E98C76D5963C" modified="2020-12-02" version="1">MKEIDDNAKKEANEAKTEIKELKKKIEGLQNSHEKEANEAKTEIXEAKTEIKELKKKIEGLQNSHEKEANEAKTEIGELKTELGKLHEKINKFELSEEELVIRQLCSSVQENLLKIVLQEYFDKFQNKRTQHMENYILWQIEDKDEQDKARLRWKDIKKAIKWDEYLLKQLKSIKMGGNETAHPSLTEEIIDAAKMNLKEKGKLGKHMGMAVDQLKAILKQTNRKLRQGSSSKGQEQGGPSVVSTTTQRPPTGSYASKAAGGLVDCFGPKQAIQSLPRPAFQKRHYSGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAG3</accession>
    <name>A0A6P8IAG3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polcalcin Jun o 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116299631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564176.1">
        <property type="nucleotide sequence ID" value="XM_031708316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAG3"/>
    <dbReference type="GeneID" id="116299631"/>
    <dbReference type="KEGG" id="aten:116299631"/>
    <dbReference type="InParanoid" id="A0A6P8IAG3"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031564176.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18261" checksum="435163A066F03B47" modified="2020-12-02" version="1">MASGGKSYFSENVPKIVVQSLFRKYDTDDSGRLQKTELMTLLKDDLGMDSKQAEAVMMLVDKDGSGAVSFEEFFQWLREGQGLKNVDNTTRYYYIRKAVDLFKTYDKDASGTIEPNELKELLKSVGYTGSVESALKVLDKDRNNKVSFPEFLQWLNWIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICA8</accession>
    <name>A0A6P8ICA8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Signal transducing adapter molecule 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563312.1">
        <property type="nucleotide sequence ID" value="XM_031707452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICA8"/>
    <dbReference type="FunCoup" id="A0A6P8ICA8">
        <property type="interactions" value="3856"/>
    </dbReference>
    <dbReference type="GeneID" id="116298874"/>
    <dbReference type="KEGG" id="aten:116298874"/>
    <dbReference type="InParanoid" id="A0A6P8ICA8"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11964">
        <property type="entry name" value="SH3_STAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03568">
        <property type="entry name" value="VHS_STAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000009">
        <property type="entry name" value="Putative signal transducing adapter molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035657">
        <property type="entry name" value="STAM1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="222"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563312.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="60910" checksum="919F312175A3AFF5" modified="2020-12-02" version="1">MPLFTSSSSYDAEVEKATSELNTTEDWQLIMEICDRIPRETTGPKDALRSIMKRVNNRNPHIAMQALTLLSACVNNCGKVFHLEICSREFVSEAKTILQSRTHPKVLEKFKEIIVEMIGIFNDDSQLSLVSTMRDQLAADGVEFPSSSKSSPNTSSKSSKSSSSSSPSRGSSALSSKEDEDLAKAIQLSLREAEESKPKVSSLYPSVMDSSSSYYAPVRKSQSKKKVKALYDFEAAEDNELTFKAGDIISVLDDSDANWWKGEMRDVTGLFPSNFVTSDLSEPKAKVEKKKRVRWADTPAGNQELQKQQAPAVKPEINEEKIEQCITMLKGACVENDDEQEDTIIDLEVACQQMEKIVDEKIENSKTKHQDLSSLNEQYLQALALYQKLMKEPIPIPPTPTPTPTMPAGYGALPRSAAGAGYQQQTMNGYQPPQYQQMYAPQVPAGYSQISYPMAAQPSMNAAYSSQGPGVPSYPAGTITTTPSITQGYPQPPQQYVTQQQMHTPQHGVPQEYAPQGPMQQYQPQPHPGGYGSFQHQPQHQMVYSQPQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICR1</accession>
    <name>A0A6P8ICR1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclosome subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116299133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563627.1">
        <property type="nucleotide sequence ID" value="XM_031707767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICR1"/>
    <dbReference type="FunCoup" id="A0A6P8ICR1">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="GeneID" id="116299133"/>
    <dbReference type="KEGG" id="aten:116299133"/>
    <dbReference type="InParanoid" id="A0A6P8ICR1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031563627.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9152" checksum="2595019BCCF0827F" modified="2020-12-02" version="1">MSKDSELSYSHRNGRLVDIIDDEWKNEKLPNEEIAVPEFELPPIDDTDNSGTVESLKEQEEKWTDLGISQLQESQPVNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID77</accession>
    <name>A0A6P8ID77_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116298850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563280.1">
        <property type="nucleotide sequence ID" value="XM_031707420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID77"/>
    <dbReference type="FunCoup" id="A0A6P8ID77">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="GeneID" id="116298850"/>
    <dbReference type="KEGG" id="aten:116298850"/>
    <dbReference type="InParanoid" id="A0A6P8ID77"/>
    <dbReference type="OrthoDB" id="5979667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024883">
        <property type="entry name" value="Neurensin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14796:SF3">
        <property type="entry name" value="NEURENSIN 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14796">
        <property type="entry name" value="NEURENSIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14927">
        <property type="entry name" value="Neurensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563280.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29363" checksum="92FAA0366CDEC336" modified="2020-12-02" version="1">MNFNMNPAQEKQSGSKDATDIRQGPKKTRKVKTRSSRGKKVQTDRTNSRFGIRYLHHHMFEEGTPESKQPCPSVECKCGSGMAAVYSAKTLIALTCSILILLIGVTFMLVGYVIPRRPVVYIERGDGSRIPVDKTALTFNTMLDDFTLVGTVLISIGALLFCVVLLLPVCRATNRRGDYRKAPTEEAPVRREMSMDSLSSSNQTDSLERRSSSGATSSSSSIQKIPVLALVHNVQQREPQRSPSNIHEYRLAANKHKDSFEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID83</accession>
    <name>A0A6P8ID83_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564027.1">
        <property type="nucleotide sequence ID" value="XM_031708167.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ID83">
        <property type="interactions" value="1622"/>
    </dbReference>
    <dbReference type="GeneID" id="116299505"/>
    <dbReference type="KEGG" id="aten:116299505"/>
    <dbReference type="InParanoid" id="A0A6P8ID83"/>
    <dbReference type="OrthoDB" id="187568at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031564027.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58611" checksum="D39B0B50E6E5BEC2" modified="2020-12-02" version="1">MATKCARGKVPPKTAQFFHSLPHVNFNFENISSTFEPTDTDYQQNFWLYSGVPVLCGGVLFLIVIIIFLAFCCWWCHKLRKKQISKRKTKNKCAACLALLIWXFSFICCGSIIAGFVFNDDIENGVKNVTMAIKNVSDTFDNIQNEVSGVQNNLLDIRSSIRRLILDSPDIPDEVREILDEIQETVLSIIQALRGVKKQQAPDVDTYIKTGEXYRWWAAFGILGLGILTCLFAGYSTIRHSRCGFVMAILIGCVAFLLEWVLLGSHLGASIAMSDLCINPRKTIDFYTRQSSLVVKGIVNYYVDCKPDSEHPYEQYVKESLSFAQDGEVLFKELEKRWPSKRSEIREVVKNFNQSKTDLMGLQDELKCTGFQQQYKKAQCAVCFPVVEGLSKLLLISIILVVFLALILLFIIPICKRIHRQKRTGNAVGSMLSTGDQSLETEYHSVTSDDESLPLIPSTPPPPYEAVARSVDYQFHSCQEDRXPVNSPTQPEENQPNNMAPPPPRGDIVSNPNRVNTMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDA1</accession>
    <name>A0A6P8IDA1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TATA element modulatory factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116298890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563330.1">
        <property type="nucleotide sequence ID" value="XM_031707470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDA1"/>
    <dbReference type="FunCoup" id="A0A6P8IDA1">
        <property type="interactions" value="2298"/>
    </dbReference>
    <dbReference type="GeneID" id="116298890"/>
    <dbReference type="KEGG" id="aten:116298890"/>
    <dbReference type="InParanoid" id="A0A6P8IDA1"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1034"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="580"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031563330.1"/>
        </source>
    </evidence>
    <sequence length="1198" mass="135267" checksum="D84D99F2A396068F" modified="2020-12-02" version="1">MSWFDASSFTSYAKTALASAQKSIDKVLDIDETTAASSKNKNADVKDKESTESASVNTQKESGVKLQSSKPQSNSNTSTQKDSSKDNSSVDGGGDFWSSFLGTSSASSASTLSSSSSSSSADKKTKTLPSSKQNDSKVQNKRTSNHGETLEKRRQKKRENRINDSNGVTKNQNQKERSNNEDLKAMCDKEASHDMKDGNGKIHIGNEMRVSSTDSSGQQTPHKSYISKDSKELSPLNDEKLNEAKTENIFPIKDEQKLQLVKENNLGNKREILRQVDGIKKENDQTGSTFKSEKMGKELKDNDTENTGEVKYYEGKETSNLSPETLESQSVTEDSENLDVVSKNIESLLHTAPRATSTPYTEKLKVLTGDEHVCEDDVGLSRKTKKSLLTEGGKSRPQEQEETGGRKEPVEDECDGEDVITGSVYTVEENMQDEEDNLEKSSSNDVIEIAESIIKLSKQGESTKTSPTLEKQDSEDINLEVTGELTKDETSPAIEKQESQEDNLEVTGELTKDYQNLVKEKEHESALSEESLEEKTVAAQENRNEEPNSIQVQTLLKEVSGLKELVDARESKMVALSKENIDLQETNAILRSQLEQLEKVHNSEDEEFEEMKEEFTTRIAATENKFHEVAKERDDLKMELEETRNNLTAIYERQKEELTTIISEKDEQIVQLLAEGEKLSKQELQSNMTIRKLRAKEKENDTLIKKQTKKLEEYENEVKRLTDILTSRDDSHSKQEDAIIKLNAYVKKQEEQLSKQTSELEDANEKVRSMQVALDNAYKEMTSLQKQAASSDSSIQEAVLSAEMKAKEELRIALEKARREYGQDSELMALQISDLQTNLSRAEKQAIRREESLREEIKDLQQRIQEAEDRNQDLAASVSHATRPLLRQIENLQATHSGQASTWEMVEKNLTERLNEAQSQLLAAQEKERVASRNVSELNSRITRLESQVNSYRTERARLEAELELERTKVGSLEDIHSREVAKSDAVVKKYKKLIEEANMDKAHLEQQLAVEKSRLETELKKVKAALENKEKLLSRQSSLSNAPPPSPSDNGEPNQDDEAIELKTHIRKTSSSSSVVDGLARGFLGGTTELVERLQAQIRQKDGEIKVLQDEVTSLRQSRDSVMEELTKMISELHDLETSHEQLILLKAKYDDLEQRYNAVLQMYGEKEEEAEELRMDLHDVKSMYKQQLEQLFGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFU0</accession>
    <name>A0A6P8IFU0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear receptor corepressor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565620.1">
        <property type="nucleotide sequence ID" value="XM_031709760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFU0"/>
    <dbReference type="GeneID" id="116300808"/>
    <dbReference type="KEGG" id="aten:116300808"/>
    <dbReference type="InParanoid" id="A0A6P8IFU0"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565620.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11867" checksum="8FF1DF313498D4E2" modified="2020-12-02" version="1">MQITKVKILTPHLQRSDIFYNKWKKEEIKIFEKLYVKLSRSGNKRHVFESIANNLPNKTTRDCVQYYYLFKNIGTFKTKLRKGKKKKTKSPCTTLTHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGT0</accession>
    <name>A0A6P8IGT0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116301075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565934.1">
        <property type="nucleotide sequence ID" value="XM_031710074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGT0"/>
    <dbReference type="GeneID" id="116301075"/>
    <dbReference type="KEGG" id="aten:116301075"/>
    <dbReference type="InParanoid" id="A0A6P8IGT0"/>
    <dbReference type="OrthoDB" id="5969496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565934.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36914" checksum="2E352BF52AB507E3" modified="2020-12-02" version="1">MTKPECTSCLLWLIPAVLLLVYIVVRKCLSFQKVKNISKKFVLITGCDKGFGRLAAIELDLLGFQIIATCLTTQGKDDLERVCSQRTKVFLLDVTKTKQIKEVYSEVNRFIPKDVGLWALINNAGIFIPGPVEWQPLDAFKRTADVNLWGVIDMTKTFLPLVRKAQGRIVNLSSIAGRMPFTYMSAYCITKFGVETFSDVLRREVKPFGVKVILIEPSGYKTPLMNEEYMKISWNKEWEDLSDEAKDVYDDEYRGKAFKALRNTFSTASDDIGMVVKALEVAVTSKAPRDRYLVGLTASVLAFIAFLPSAIVDTLANFAVPTSFGRKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHL9</accession>
    <name>A0A6P8IHL9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116301322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566219.1">
        <property type="nucleotide sequence ID" value="XM_031710359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHL9"/>
    <dbReference type="GeneID" id="116301322"/>
    <dbReference type="KEGG" id="aten:116301322"/>
    <dbReference type="InParanoid" id="A0A6P8IHL9"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="116"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="211"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="305"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="413"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="529"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="626"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="544"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566219.1"/>
        </source>
    </evidence>
    <sequence length="726" mass="80011" checksum="FB755D631316A3BB" modified="2020-12-02" version="1">MPERKSLKNTILLYLVKVAKSAISNILVIARDYVFGILQVYHNGQWGMVSRNSFEWNDVHSACRRLGFIKATNYGHDGRGDGSVLRPTSKSRNSVYPVSMFICIPQCHCNIHHNAVYYKGQWGTVCNDIWGWNHANVTCRQLGFTKAASYWGWGRGEGTVWLDYMACTGSEASLQDCPHNGWGVVSSNCNGHTEDASVHCDSTDTRGYVFGAIQVYYKGQWGTVCSDYWGSNDANVACRQLGFTKAVGSWVYGRGEGPIWLDNMACTGSEASLGDCSHPGWGVVSSGCKTHTIDAIVQFSGYCYYSNGQWGTVCYNSWGMDDTKVACRQLGFTKALNYWGGHGEGPVWLDDMRCTGSEASLEDCSHPGWGVVSSNCNGHTSDAGVWCSSLQVLFRIFSFYMRKQHKCSYEPHIRALRSDTRGFVEGVIQVYHNGQWGTVCGDYWDSNDANVACRQLGFSKALGAWCCGEGGGEYPINSRGYGRGEGQVWLDSLKCTGSEATLWDCPHPAWGVVDPGCRSHTVDAMVECSVSQDFWSWEETKVACSQLGFTKAAYYWGSGHGEGPVWLDDMTCTGSEASLQDCSHPGWGNVSSHCNSHTYDAGVICSGSLLCNKDNEIYTRRAIRWSKIVNEKTTKSDTRGHVIGVIQVYYKGQWGTVCHDYWDINDAKVACRQLGFATAVSYGYDGHGEGPVWLDDMTCTGSEASLQDCSHPGWGVKIAVLRSDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHQ1</accession>
    <name>A0A6P8IHQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DENN domain-containing protein 4C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116301310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031566205.1">
        <property type="nucleotide sequence ID" value="XM_031710345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHQ1"/>
    <dbReference type="FunCoup" id="A0A6P8IHQ1">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="GeneID" id="116301310"/>
    <dbReference type="KEGG" id="aten:116301310"/>
    <dbReference type="InParanoid" id="A0A6P8IHQ1"/>
    <dbReference type="OrthoDB" id="75250at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018798">
        <property type="entry name" value="MVB12A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10240">
        <property type="entry name" value="DUF2464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="MABP" evidence="4">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="188"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031566205.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="76286" checksum="41DB49469F433008" modified="2020-12-02" version="1">MVDKEKPQRVADYFVVAGLGKTSKPSDVDKLGDEKTIFLEPITDLAVVFKSLGEKPPPGYTCIEKSPAGLSADLNLGSIRQPSCFLCYRRGLDKPPLTDIGVLYEDKDRLVSGCDLITQTPYGRSANVNNSGGSRTFITYRRASQQMAHTSLAVTEICVIVASKGEKPPHAFCIIDRNLNKGMVGSDVFLCYRKSLSRSRSVTYQPEILSRFPPLDYEDFPLPDGVPMFCLPFGTIIECWPEKCPHPLPSFSTFVLTGASGQKIYGTAVTFFEILPESLMTDNLRQALNLNEKREDNVIMNPHTNKCICILSHWPFFEAFKKFLSQLYRISVSAQPIPIEKYIAKLMLNVPFPSPQIPRILIEMMRFEPFEISQPYHTPLPVSGASYTAMLRHLKAENMLLLFYLVLTEHKILFHSLRPALLTSVAEALTTILFPFTWQCPYIPLCPVALNDVLCAPCPFIIGIDSRYFDQYDPPDDVTCIDLDTNMVSLASEIKPASWKSLPKKPGKVLRDRLTDLYCQMYQQYHKEKEAFGADITETAIELAPLDHDNSHSRRRLALEVSIQEAFLRFMATILKGYGSYLKPITSAPKEGTCDMTSLFDMQGFLKSRPNNHQKFFNLLMHTQMFSRFIEQRSFVTSQDSLLAFFDTCTDKVRFLFILFIFILLISPKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II48</accession>
    <name>A0A6P8II48_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TNF receptor-associated factor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116301596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566541.1">
        <property type="nucleotide sequence ID" value="XM_031710681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8II48"/>
    <dbReference type="FunCoup" id="A0A6P8II48">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116301596"/>
    <dbReference type="KEGG" id="aten:116301596"/>
    <dbReference type="InParanoid" id="A0A6P8II48"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="195"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="195"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031566541.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36637" checksum="A6A7BF2DB054B161" modified="2020-12-02" version="1">MRDVTVDGIPNIATHPETKALTTVSAVASLIGIASGPRVKRSMHVSNLDVLEDPMQCKDGHNFCKDCITRCLGHKQICPLGTNALELDSLSRNLFAENMVNNLKVYCHLPESDGQSAANTDTEAYELKCDWTGELQSLAQHRETCPFQQVQCPNVNCNANIQRRELEDHDKICEYKVVECEKCTQALVRLEVRFHNKIYCPEEVVPCPNGCRSLETGQINEIKRINLDNHTRNDCGKTILDCPFKDQGCLVQVERQHVDKHVQDNMAAHMMLLAKQCSSLTKQNSSLTEQCSALKQNVLSLTEENRLLKDEVKQQGNSFWQNKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIT4</accession>
    <name>A0A6P8IIT4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116301498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566428.1">
        <property type="nucleotide sequence ID" value="XM_031710568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIT4"/>
    <dbReference type="GeneID" id="116301498"/>
    <dbReference type="KEGG" id="aten:116301498"/>
    <dbReference type="InParanoid" id="A0A6P8IIT4"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF25">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031566428.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18180" checksum="666B15FA9799C2BF" modified="2020-12-02" version="1">MAGENRDKDLYFQVEGIKYEDIAEMYDSEDQHRREKGLNSISIHASKTRSLAVGKEVTVNNHKIALLKYRGIVYAMDSKCPHMGGPLHLGDIEELGEAKLPCIVCPWHSWKYSLSTGEIKSPLYQNVKVTVYPVIVKDNGSLHVGFERISPDYFNCIMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIW1</accession>
    <name>A0A6P8IIW1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116301815</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566796.1">
        <property type="nucleotide sequence ID" value="XM_031710936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIW1"/>
    <dbReference type="FunCoup" id="A0A6P8IIW1">
        <property type="interactions" value="914"/>
    </dbReference>
    <dbReference type="GeneID" id="116301815"/>
    <dbReference type="KEGG" id="aten:116301815"/>
    <dbReference type="InParanoid" id="A0A6P8IIW1"/>
    <dbReference type="OrthoDB" id="1580043at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566796.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34790" checksum="A754E829CEA3DC0B" modified="2020-12-02" version="1">MPLAWSFTAIIGAFVLGETVRFLLKKIIPRRSPHHHYVGELISSFEFSAGVFEIAVIGKYYSNLLGFIFSFTFLFLKNSEYILDRKAANPCGLLEGIVRRDVRRSWVVDFVTKVSSQLTGALLAFPFMKLVWQSTASEIHFKQLSRGLSSSLEVSVLVGFSIEITATFVLTMIDFLTRGGLRKFNPLVRAGACVLICYALTGTTGVWMNPVFATVHTFLFTDAKEDILEHFFVFWIAPIFGTLIAIAIDSKLHEPERKSPAIAKTILKKRKKHAVSNEAASQNGKVTNGKANGVSVSNTKARQRKTNYGAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILA9</accession>
    <name>A0A6P8ILA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neuronal acetylcholine receptor subunit alpha-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567589.1">
        <property type="nucleotide sequence ID" value="XM_031711729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILA9"/>
    <dbReference type="GeneID" id="116302440"/>
    <dbReference type="KEGG" id="aten:116302440"/>
    <dbReference type="InParanoid" id="A0A6P8ILA9"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="58"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567589.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33172" checksum="874C355C5D49930D" modified="2020-12-02" version="1">MHWKKMLRKKKTNNTFLVCRGFSTKVNLMRSSCCPEPYPDITFYIHIRRDPGFYLFNIIVPCMFLTMLSVLTFLLPPEFGERITLVIESFFAMAVIILNVSDQIPVTSDATPILVHMLLISMFQIGGCLVANAIALNLYKNYEVPEWVRVVILHYLSRCLFMKSAGEIESPAPVDMRMLDDANHHQTKLAGAKHYNGPLDSRAKITTNLDGLGLKQMYDPFDTPDMAKIADGFQELARHAVRENESDKDREFMHFTCIVMDRVFFILFFFILTGSFWKIFGEVPAHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILM4</accession>
    <name>A0A6P8ILM4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AAR2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">AAR2 splicing factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116302223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with PRPF8 (via RNase H homology domain). Component of a U5 snRNP complex that contains PRPF8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567313.1">
        <property type="nucleotide sequence ID" value="XM_031711453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILM4"/>
    <dbReference type="FunCoup" id="A0A6P8ILM4">
        <property type="interactions" value="1466"/>
    </dbReference>
    <dbReference type="GeneID" id="116302223"/>
    <dbReference type="KEGG" id="aten:116302223"/>
    <dbReference type="InParanoid" id="A0A6P8ILM4"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.550:FF:000001">
        <property type="entry name" value="AAR2 splicing factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.20:FF:000001">
        <property type="entry name" value="protein AAR2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="9">
        <location>
            <begin position="191"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567313.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41457" checksum="DA129566A58A4511" modified="2020-12-02" version="1">MAEMDPDVAKHLFSEGGMLLIFDVPKGTEFGIDYNSWKVGSKFKGVKMIPPGIHFVFYSAVSKEGQTAPRTGFFCSLEKRHVLVKKWDREVEDVVQGDESSENIERIRTGMEELDQYLGAYPYDSYKKWLSLSDKISQPLLERLQPTCGKISSVTQVPSHEEFRSEASKMEIDEENLNISFEQSPENKIRFTEIPKRRYPEGSSPVEITRHSLDSTYILECMISHMTDKMEILGELQFAFVCFLLGQVYDAFEHWKGLVQVLCTCDDALTKHPDLFHAFIGVLHFQLLEAPKDFFVDIVTKNNFLTVTLQVFFSNLETSANVDENLVKKAQRFRKHLTKRFKWDFESEPDEYEPVIVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMG1</accession>
    <name>A0A6P8IMG1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0728 protein v1g117062-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0728 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567760.1">
        <property type="nucleotide sequence ID" value="XM_031711900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMG1"/>
    <dbReference type="FunCoup" id="A0A6P8IMG1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="116302568"/>
    <dbReference type="KEGG" id="aten:116302568"/>
    <dbReference type="InParanoid" id="A0A6P8IMG1"/>
    <dbReference type="OrthoDB" id="10003460at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027885">
        <property type="entry name" value="UPF0728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28448">
        <property type="entry name" value="UPF0728 PROTEIN C10ORF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28448:SF1">
        <property type="entry name" value="UPF0728 PROTEIN C10ORF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15092">
        <property type="entry name" value="UPF0728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567760.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10219" checksum="8CCE2DF2CCCE90AA" modified="2020-12-02" version="1">MKHKVTVKFGPYVSCGLLEHRTARLEGLQELLRSNDHTVEFVKIPDRDVVELVVHGEVIYQCKIQDLRYGGDGKLDPVCHEALEAVNKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ75</accession>
    <name>A0A6P8IQ75_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116303626</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116303626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569059.1">
        <property type="nucleotide sequence ID" value="XM_031713199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQ75"/>
    <dbReference type="GeneID" id="116303626"/>
    <dbReference type="KEGG" id="aten:116303626"/>
    <dbReference type="InParanoid" id="A0A6P8IQ75"/>
    <dbReference type="OrthoDB" id="5990232at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031569059.1"/>
        </source>
    </evidence>
    <sequence length="828" mass="90977" checksum="0638AC21BB683F02" modified="2020-12-02" version="1">MSLAPLLRTKLSKESEQKLDRLMQEQEEDTLCMKELQKRKPLPPYRKERRRTIAAKSNNRKESTEKDETKDQTDAIEISDEETSDSESVVEIQHEEKKRMKVIFLKFHENNRPPYYGTQRKKSKKISPKDPLKKDEGLLNYEIDSDDEWEEEEPGESLSDDSDGDDDDAEDGEDEDEDGFMVPHGYLSDDEGIDADDEENQVDSASKEQQQLAKVKAWEAELKRKCKAKKPVCIGCVWPDDKNIHEMLQQFEACVLIDEPTIAIRTTSSASADSCSQSMRENSTATPDSVNKSGMYVPEEAMPDLITLIHRSTAGVAKLINYFKQHWSKKCESTKIHPSLAGKGHISKRQLEAKIKAIATKERRSDKTRWYVNSNILNAYGMTKLAATDNEQGTPNVMSCSPQMSNTGIKISTKSVSPSVNQGLSAVPRVMTSPHLQTSSSTQDKLQSISTTTEAASSAQLLQAQNDKQSSVTPIAKRRVVLEPVSKPEVEAVIAKENLPKKEASSIGQRLQAQDDKQSSVTPVVKRRVVLQPVFKPEVGAAIAKENLPNKEASSIGQRLQAQDDKQSSVTPVVKLRVVLQPVSKPEVRAVIAKENHTNQQDIPNGQTTQVQNDKSTSIRPVAKRRVVLQPISKPDIGGISSKANQSNPSLSGEEQSSDAVETTNSCTVPSMNTIISSKNTEQGTNTITSDGLTKSSLSSTITITSNSPSTPPHDIGGLSSAVKRTAPSPVGTERVAKVPRKSEESVEIRCDVNKPVPVASVGDTTNRASAQLPLDSSQHPKESQESSSNSISDDAAKVENSLQCTLMTNVCKTDGIQPMEIEQIIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQM8</accession>
    <name>A0A6P8IQM8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116303781</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031569244.1">
        <property type="nucleotide sequence ID" value="XM_031713384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQM8"/>
    <dbReference type="FunCoup" id="A0A6P8IQM8">
        <property type="interactions" value="2002"/>
    </dbReference>
    <dbReference type="GeneID" id="116303781"/>
    <dbReference type="KEGG" id="aten:116303781"/>
    <dbReference type="InParanoid" id="A0A6P8IQM8"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="13">
        <location>
            <begin position="137"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="293"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031569244.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50518" checksum="1AAB7A509CFACB0E" modified="2020-12-02" version="1">MSGIEEYNNENLIVTPPVTSRGCRTLNREDFTKVFRLPALRIDAKKCSLFMKSFRKLLLNRPRLRNIVPDPSNENNSKKLVLLRPGVLLNEEEKEFICTHNADETVHDLVLDYNFWTSEQVLRAILPPEISEVPSAFETIGHIAHVNLRENQLEYKSVIGQVLLDKNSPQIKTVVNKTNTIDETFRFFKMELLAGEDNMNATVKEDGCIFEFDFSQVYWNSRLQTEHKRLVEIFSKTDIICDMFAGVGPFAIPAAKKGCYVHANDLNPSSYEALVKNAKLNKVEKNIIAYNMDGKEFVRKMVESLADKSGSGNQMFNHVIMNLPASAVQFLDVFKGLFINFKDRFRVDDSSKSRVILPMVHCYCFSKSEAPEQDAQSQAEVILGVKMGSDCKVHYVRDVAPKKAMLCVSFRLPASVAFCEHDQKQRDDSEPPSKQAKIEEDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQY0</accession>
    <name>A0A6P8IQY0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">YEATS domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116303422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568815.1">
        <property type="nucleotide sequence ID" value="XM_031712955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQY0"/>
    <dbReference type="FunCoup" id="A0A6P8IQY0">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="GeneID" id="116303422"/>
    <dbReference type="KEGG" id="aten:116303422"/>
    <dbReference type="InParanoid" id="A0A6P8IQY0"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16907">
        <property type="entry name" value="YEATS_YEATS2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000001">
        <property type="entry name" value="YEATS domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055127">
        <property type="entry name" value="YEATS2_3HBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22951">
        <property type="entry name" value="3HBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="YEATS" evidence="12">
        <location>
            <begin position="378"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="523"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568815.1"/>
        </source>
    </evidence>
    <sequence length="901" mass="99892" checksum="F2A8174AFD2E37FD" modified="2020-12-02" version="1">MDFSSSENAENNQENGIEDCQGITETVDPDYVSILPEKLQSKVCLSEQQQDAKDNAVQKIKNIVRKQFTMEMHLKEQEIETIDQRIRQTKTSLDRLRACILARYYGMSQDFQEESLIRSFAGKSSWSKPRRSRRECANNQSSSKVLKSNRSKLLNSTGSFSARNLGNSQLSPSMDINANKPPLGKKSSSFEDNKNPVSSALFDFENTACVNLEMTNGEAERTSVVAKVSALATSGNSNLSASMTKGSQQQSIVTSDISITHSSVASTSSLGSHSSRYLDLKGIQLNASGTHLSASRTHLSASGTQSNASGTLSSTSLQRSNLVDTQAKKVMKSHLAVTSSEETSKNSQGRQLNGSSILKVTHMNATKDAVSQSNAFGSGARFYVKKRVIIGNTSKYIPPEKREENDKSTHKWMVYVRGPPEDPHIDVYIQKVWFFLHPSYRPNDIIEVNKPPFHLTRRGWGEFPIRVQLHFVGTRNKRVDIIHELKLDKTYTGLQTLGAETVVDLEIDKKTFEDLGIPVSWEIPQDTSSASDTTSKTDINSIKNPEVVKLKREHSSSATSSETGQLPGASSIKRSRLDTPMSSVASTPCGSRISSRCASPVLRNTSEILEDGTEDYLHSFAEKIPLISSKKDVVKHPFSAKSAEEFLSWNVGKRRAAEWQRAAKIRAQFKKCAQNTDMTTKGVMIWCRRFGYTPQENLVTDEKVEYCKICGKIIEQVTKENLDTGIVFSCTGEKCSKVAQMELSSLTLVEDILKEVEDKEKLFNETSSQKESEEDVDIDVVSSFDTKKPSVSIPNSLGTISIPLTPQQQWIKDICNDISISLRPLTIQNVEVNAIESMLLKLAMKFAETLLRKASSLSKKDDASLDPNLIIPFHIYQAIGSLSLCDFMGNAFFGHASEDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRE3</accession>
    <name>A0A6P8IRE3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC116304037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031569544.1">
        <property type="nucleotide sequence ID" value="XM_031713684.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569545.1">
        <property type="nucleotide sequence ID" value="XM_031713685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRE3"/>
    <dbReference type="GeneID" id="116304037"/>
    <dbReference type="KEGG" id="aten:116304037"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF126">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031569545.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="32319" checksum="A9421FF389795DA5" modified="2020-12-02" version="1">MASSQRLSTYYDFVMAVGDPRTHEWPLVATPWPTIFLMAIYLLIVKIGPKYMENRKAWDLREVLVVYNFGLVFLSGYMLYEFIASILSMPDFNLMCERVRYEDDPRQLRLARVIYIYYLSKFVEFFDTFFFILRKKNNQITFLHVYHHATMCLLWWMVCKWIAGGITYFGASFNSFIHIIMYLYYGLSAMGPSVRKYLWWKRYLTKMQLIQFLAVIYTASYALYHDDCGNPRFFLWLQLGYGMTLMILFSHFYMMTYIKKGDEKNKKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS63</accession>
    <name>A0A6P8IS63_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenylate kinase isoenzyme 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116303641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031569078.1">
        <property type="nucleotide sequence ID" value="XM_031713218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS63"/>
    <dbReference type="FunCoup" id="A0A6P8IS63">
        <property type="interactions" value="2233"/>
    </dbReference>
    <dbReference type="GeneID" id="116303641"/>
    <dbReference type="KEGG" id="aten:116303641"/>
    <dbReference type="InParanoid" id="A0A6P8IS63"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031569078.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11974" checksum="DB390BA71F097358" modified="2020-12-02" version="1">MSDGGNIIDYHGCEFFPERWFDIVFVLRTDNTILYDRLEQRGYAGKKLSNNIDCEIFQTILEEARESYSKEIVHELPSNTPEDMERNLEQIQLWLQQWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISA3</accession>
    <name>A0A6P8ISA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable S-adenosylmethionine-dependent methyltransferase At5g38100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569854.1">
        <property type="nucleotide sequence ID" value="XM_031713994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304287"/>
    <dbReference type="KEGG" id="aten:116304287"/>
    <dbReference type="InParanoid" id="A0A6P8ISA3"/>
    <dbReference type="OrthoDB" id="1890922at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569854.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37099" checksum="1615577BEE082585" modified="2020-12-02" version="1">MALEKQSVVTLVDYGTADGGISMDLIYACVKAIREKYGAELPINVIYEDQPVNDFTSVFLRTQGLVPGPRSYLLDFPNVFVMASGTNFYDQCFPNDSVTLGFSSNCTHWLRDKPCDITGTIFPLFTTVPEEKEKFRVQAERDWELYLTKRAAELRPGGSMILAEVVLTEDGQFTGHTNDSKYSCITLLSTLWKSLADDGVITDDVFTKTNLSAYVKTVDDFKKPFKCPNSPVIKAGLELVSIDTKITPCPYKGKWIKEKGDAKEHAKKYVGSIRAWSNSTFLSGLSDSXSXEEKSXIVDELYHRYEXEVAKCPEDXGXDXVNAYLVLRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISA7</accession>
    <name>A0A6P8ISA7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Uncharacterized protein LOC116303758 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116303758</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569215.1">
        <property type="nucleotide sequence ID" value="XM_031713355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303758"/>
    <dbReference type="KEGG" id="aten:116303758"/>
    <dbReference type="InParanoid" id="A0A6P8ISA7"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF142">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028206292" evidence="18">
        <location>
            <begin position="23"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1648"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="20">
        <location>
            <begin position="155"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="321"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="20">
        <location>
            <begin position="473"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="20">
        <location>
            <begin position="682"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="861"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="968"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="1076"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="22">
        <location>
            <begin position="1175"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="19">
        <location>
            <begin position="1283"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="19">
        <location>
            <begin position="1444"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="23">
        <location>
            <begin position="1889"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1573"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1731"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1573"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1589"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1742"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031569215.1"/>
        </source>
    </evidence>
    <sequence length="1962" mass="217073" checksum="B34C933A6AD23DEF" modified="2020-12-02" version="1">MMESCCSMSLLLYIAIISVCLPQPSFFTVLADPDHSACNFKRCSCQDTSISCQGNLGEKELKNIPKDTENIIFQDGLNCDCETVKLVEWASDKRITIDGKCNEPAHLAGQPVNEINKEQLKCGHTHVRKRRSIIENETLNFTDTKPTGPDGLPLWPCDFEENFCQWFQLSDSDFKWTRQNGSTKSHFTGPNGDHTFGNGTYIYIETSVPKQLNDKTRLVSPTLRPVKANQTCNMTFYVHMYGNNIGQLNIYQAPVIGHDTLKKFFKTSQGDAWLKEEVTFDSNEEFQIIFEGVRGNGYQGDIALDDISFSTGCQRLVPGYVRLRSADPKAFNTGVVDIYNNGSWGQVCRDGWTSADASVACRELGFDSVKQISAVSTNGLSITGLTSLNCTGTETSVNKCPRSAWSKATLCTSNQTASLGCTGIAPVCPLKTHMYCPKKPGEPTAKCISLGQRCDFIDDCWDGSDERDCNNYTRCTFEEADFCGWLQAVNDHMNWTRHRGSTPTQSTGPSQDHNGDASKYYIYINVAGRAAEKAKIAVTPRFQGNHQGLCKVRFFYHMYGWGTGSLRVLITDQYTVRTLWQKKGRLGDQWNRAEVTLLNTSKSFQVVFEAEHTGYVSQGDIAIDDVSFTPECLPAKHENISCSPSTFKCSSLECISLEDRCDFKMDCFDGTDERNCGFNTPGRCNFEGNFCDWNNETDDKFDFERHQGSTVSFGTGPSYDHTLGYGQRGFYAYIESSHPRKNGDKARLVGPQFMWKNITGCKIRFFYHMWSIRYNVVGTLKVMLRNPITRETVTIWQKFGSQDNKWILADVPIATNWSIAEVVIEATRGQSYLSDIAIDDISFTPQCYPPIPSHVDKNYDVRLVGSKSSYQGRVEVFRVGYWGTVCNDGWDKNDAQVVCRQLGYAGAMNVFPSFGSGKGQIWLDDIKCIGNESNLNMCGHNGWSNHNCDHSKDATAVCDISGGTTAPIRLTGHTNDTHGGRVEVHYHNKWGSICFDEWDLHDAHVVCRQAGFLGVEKVMSEPSESTGHIWLSKVKCEGNENSLDKCQHSDWSVVSSCSHGYAGVVCKRSGASEGDIRLTGGRSQKEGRLEIFHRGEWGTVCEDYWSKEDAKVVCNELGFTSVVKVYQSFGPGTGQVWLHNLQCYGNETSLTQCRHGRWATSPCSHDEDVGLICGDNSYIGCYKDNDPRVMSHKSTMKDLTPVRCLQYCQSKGYSYLGLEWSTECYCGNHYDKYGNASASECSSPCAGDPSKTCGGPWRLSVYTTNPAILPSSAPGYLPVRQSCSSVSYIRNYGFLSSLASPNYFSGDHQSGYIWSPLYPSNYPNKIHCVWVLNLMPGSKARIEFIDFQTEKDFDYLEVRDGKRIYNQPLTPRFGFSGNKSSILTASSNTMWIKFYADISINAKGFKLRYVSSGLSMSTTPATTLTTPTLSPSSLPIIQNVIGGCNGVLDAVNTTFGYYDYYHDTGFIRSPGYPTQLYGNNLQCQWSVFVQQGYKIIMKVTDMDLHASSNDNLVIDDGHHTERSTGRSLPWSFQSTDRFLRVYFSTDSSGQAKGFMMKYERVVLNHVISTSPLPTTTTLPTTTTPATTTQRMSSSTDDKSQSTASFVPRTTSAVTSYATTKEPPSDGNGSGGNYDKRSANDKGMSGGSIAGIVVGFIVLILIIIILVLILLKNKKKRRNPQARHCFINEAYDNTDGMVMANAGAMAPHGLQDNTIFYASAAVAPPPYTPEAAANDPTPGYTVPTPTAPSEQVYSNLYSRPPPYNQYNDADSNSTTTGIGSVTNLRAAANDGQQAVEATAFPPLSGVLPGNGLPSVDGDTAFVKSVLPPIGIPAQDTKTPLPDDQAGPLPEKPPLTVVPVTNNNHPPARPNGLAPLEGINRCPASVAFGAEVPFEFICPISNEIMKRPVSASDGYTYDRRAIKSWFRQNRTSPMTNEPITDFTLRANEHLEARIKEFVRAHSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISS3</accession>
    <name>A0A6P8ISS3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116303811</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_031569273.1">
        <property type="nucleotide sequence ID" value="XM_031713413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISS3"/>
    <dbReference type="GeneID" id="116303811"/>
    <dbReference type="KEGG" id="aten:116303811"/>
    <dbReference type="InParanoid" id="A0A6P8ISS3"/>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23434">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000020">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 19" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="20">
        <location>
            <begin position="410"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031569273.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61407" checksum="3887C8766BD68525" modified="2020-12-02" version="1">MIFRRRRVFLIALIILWFLGIIYFTTDFGLLSRSRPKYVHNEEGIKRPPFDEKKYLEGDALKQGEDAYGQNQFNQAISDKVPSDRNIPDTRHSQCSSQVYSKSLPATSIIITFHNEARSTLLRTVRSILNRSPPNLVKEIILVDDYSDNDGDGAELVGLPKVKILRNDRREGLIRSRVRGSDIASSEILTFLDSHCECNTDWLQPLLQRVVEDRKAVVSPIIDVISMDDFNYIGASADIKGGFDWSLHFKWDNLTPEQKQARRNTPIAPIKTPMIAGGLFMVDKAWFEKIGKYDVMMDIWGGENFEISFRTWQCGGSMEIIPCSRVGHVFRKRHPYSFPDGNANTYMKNTRRTAEVWMDEYKRFYYAARPMARSAAYGNVMARKELRSRLKCKPFKWYLENVYPELQIPDNQDISFGELKQGKRCLDTLGSQAGGTVGMFDCHGQGGNQEWALTKKSTVRHLDLCLTIPGTSPGSVVKIEGCRDADDKQIWEHTPSRSVRHKSSGMCLDSTDSKSKIVLEVCKEGTYSQIWQFSLNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT63</accession>
    <name>A0A6P8IT63_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-rich protein 36-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570122.1">
        <property type="nucleotide sequence ID" value="XM_031714262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT63"/>
    <dbReference type="GeneID" id="116304517"/>
    <dbReference type="KEGG" id="aten:116304517"/>
    <dbReference type="InParanoid" id="A0A6P8IT63"/>
    <dbReference type="OrthoDB" id="10314028at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570122.1"/>
        </source>
    </evidence>
    <sequence length="715" mass="77510" checksum="E7D7BF80C85A4771" modified="2020-12-02" version="1">MNGCNVVLVVVISSMIINGGLVKGLRGKKGTKHQHEFLTPSKNYESQKEQNDMVKSRTSRKGLPEKNMRAAFNTGTSYAETKAKMVVKQGSLVARDQLSEADSEVSALPYIALPPNNVLPDDDKKKISISKLGNRNSVTKQHIPVTAIPLVVTATASSTIQIPPSPKPPIPTPTPHSTTHPTPQPVNINLVLPTMPPIVQKPSPPLNHPKELEESNVTKIDLSLNIGEEHQKERPVIIQVPPTNPPSGVGEVVSQIQKAQEMNSQLSLLANTPLQRPLQGPPLWNTPSVVASMLGMRNPPYNPLSIEEMMSQNGNPYGYPPWNVPPNSLPFQETPGFISTLQQGLMRPNNPLMGPFNANQMSPVSSLSNLLSNALKSSLSQSQPDLITSALSQAALQVQAQKQPPQMLTSALTQAIAKIVSQNGEPSEEQKLTEILGAALNLPKGLDPQKRFLPTASSLKVEIVNPTTSPLLPLNPVLKQGKFIGPGEQQIISLNVSPFLPQQNPGSLSPVLPQQNPGNVPPVLPQPNPANTPPVLPQPNLANAPSLLSQPNVADTPPVLSQPNSPNAPPLPQPQVFPPQNSPANSPPMPPNTANVSPVSPQIPNQQASYNTPILDQITASALGKAMAKALVNTAKKIVYNKPATQRDRIISNNNIVHFPRRLQNFIRTTFFHSNKIPHPYLRTFLPINGLNALRPPFGPFKMRYLRHRYLCCYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT90</accession>
    <name>A0A6P8IT90_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-aminobutyric acid type B receptor subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116303948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569438.1">
        <property type="nucleotide sequence ID" value="XM_031713578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT90"/>
    <dbReference type="GeneID" id="116303948"/>
    <dbReference type="KEGG" id="aten:116303948"/>
    <dbReference type="InParanoid" id="A0A6P8IT90"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="205"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031569438.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="61836" checksum="C3A8BD415133328F" modified="2020-12-02" version="1">MTEWYTFNNTQSGQIVSCSKDEIRLAVKGAFVFERQVIREDSERTDSGLTADEYIQKLADMASGNQKKDRSSLVHSSFSFDAFWAVAIALNNSIKTLDKRNITFGSRAANKVVFEEFSKVEFKGIGGPYSYSNSSKTRDGTIAIFQFKEEKKVRIGLHVKRTNQLTFFNDTSNLWQNGAAPKDSSTVRIVVLTIDSRLYLTVSTAASIGILLGILLFTFNLVYGKYKFIKLSAPLFNNIIASGCIMCLTSIFLFGVHDISNPETNFALVCKARAWTLTIGFSCAFGAMFVKTWRIYKICTNKKLRVKLGPLSDWYLLSLVGIIVVIDLIILITWELSDPIQHKELIIDENRKEPGQTFVLFTDIIRTCHAENMVVWLTIIYVYKGILILYGLFLAYETRNVIYAHLNDSRVIGICVYNVVVLSVVGAFLSLLLEFKNYKEMYIVLSVCIIFPAVATICLIMFPKVAYRCKTNNLDDTETIANGMTTVRASFDVTSTCRPVNPHPPQPAPRVENTLQPTSTKAAVQFSYQNGIDDAPSESPKSSSHLSKREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITM5</accession>
    <name>A0A6P8ITM5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031569543.1">
        <property type="nucleotide sequence ID" value="XM_031713683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITM5"/>
    <dbReference type="FunCoup" id="A0A6P8ITM5">
        <property type="interactions" value="687"/>
    </dbReference>
    <dbReference type="GeneID" id="116304036"/>
    <dbReference type="KEGG" id="aten:116304036"/>
    <dbReference type="InParanoid" id="A0A6P8ITM5"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569543.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="33486" checksum="089F560DAE620BAB" modified="2020-12-02" version="1">MFTSWIEDFHQFYRFADANSDPRTSEWPLVKHFQGPVVLILVYLTIVLVGPKLMGNRKPFQLKWPMAIYNAAMTILNLYIFIEVFLSTMDAGYSYSCQEVKYTDDSKELRIAAVLWWFYLSKILEFLDTIFFILRKKNNQISFLHVYHHSSMVMLWWIGIKWVAGGQSFFSAMINSFIHVIMYTYYGLSVFPALRDYLWWKKFLTQFQLLQFCTVFCHGIVSLKRKCKFPLWMQYALLAYMVSFLVLFSNFYLHSYIVKNQHSKKSSSQCKQAKTTKGKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITU9</accession>
    <name>A0A6P8ITU9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304104 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569623.1">
        <property type="nucleotide sequence ID" value="XM_031713763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITU9"/>
    <dbReference type="GeneID" id="116304104"/>
    <dbReference type="KEGG" id="aten:116304104"/>
    <dbReference type="InParanoid" id="A0A6P8ITU9"/>
    <dbReference type="OrthoDB" id="5990093at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569623.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38774" checksum="BF8AB5C21484780F" modified="2020-12-02" version="1">MMNKQCLEMLIMWFILCHILYIFWDNLWVILPLVYFILYRIFIIYDVPGEKLKFCTALKKYGLQPNEFNNLLTSKMEKLFNGITKELPSPVNTSKKKAKRCLCIRANTTNSKVLDQGNRVAIRLRILEQFKGKLSDLMKSPSCIQEETRSQGDINPSKSDHNEYHLEQAELFRELQKQGKLDSDSFDDNGYLLENNGKKCSIVSMCNKLDSITQEYIKEYEKEQKDPAKRRGQDREVAMRNGESLVKLFLPCIRIIMGRTSVDWAIANNIMSVNGYKQWKEHLWALMTFAALSVVIDALSKLPKYGSNSLFAFITSWSAGQPSNQPSNQPPDQRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU62</accession>
    <name>A0A6P8IU62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diamine acetyltransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570457.1">
        <property type="nucleotide sequence ID" value="XM_031714597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IU62"/>
    <dbReference type="GeneID" id="116304811"/>
    <dbReference type="KEGG" id="aten:116304811"/>
    <dbReference type="InParanoid" id="A0A6P8IU62"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031570457.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22007" checksum="3F5FAFA67289D13F" modified="2020-12-02" version="1">MESRRNFEVRPAVERDVPAIAKMIKGLAQYLGESDKLKTGEEELLRDGFGANQLFHCLVAEEIPIPHEDATVSIIDPARSSHRKTSTPRVKEILGIAIYFYTYSTWEGPMLYLEDLFVIPFARGQGIGTSIMKSLAKIAADKKCSRMQWMSPQGRPSVRFYEKFGAECLGDWCVFRLGKAEINELKSDAAEPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVH6</accession>
    <name>A0A6P8IVH6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase/endoribonuclease IRE1b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116305350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571104.1">
        <property type="nucleotide sequence ID" value="XM_031715244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVH6"/>
    <dbReference type="GeneID" id="116305350"/>
    <dbReference type="KEGG" id="aten:116305350"/>
    <dbReference type="InParanoid" id="A0A6P8IVH6"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="5">
        <location>
            <begin position="207"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031571104.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="40058" checksum="0DB3627D52009243" modified="2020-12-02" version="1">MQRPEEKREIINLTALADCEQVVRYLFFFEDEHFSYIVLELMEGNLDQFLNTAIKMDIKVSICQDIVQGLKFLHDQGIVHRDLKPTNILYKTHPKLCLKIADFGLSRRMDNIGSSTSVYGSNVGTRCWIAPEVLTSTKGHSKSSDVFACGLVLHYILSMKTHPFAPRIWALQYETEVNILNGNMEGWDDSLCPEAAHLLKAMFDGDKNKRPSADKEFGSPRAKRTLPLTAVETDLESSFGTIVKYVDWNDPGYVNLPAIYTKMTTRRTYQTNSVVELVRFVRNAYAHVTELPKSIQDLLLKKFVFFEYFPNLVMEVYKAVTTHGWDQTREEIKQDHRMNYHKNRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVI3</accession>
    <name>A0A6P8IVI3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Hydrolethalus syndrome protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC116305256</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HYLS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570986.1">
        <property type="nucleotide sequence ID" value="XM_031715126.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031570987.1">
        <property type="nucleotide sequence ID" value="XM_031715127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVI3"/>
    <dbReference type="GeneID" id="116305256"/>
    <dbReference type="KEGG" id="aten:116305256"/>
    <dbReference type="OrthoDB" id="6343432at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052319">
        <property type="entry name" value="Centriolar_ciliogenesis_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027918">
        <property type="entry name" value="HYLS1_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34174:SF1">
        <property type="entry name" value="CENTRIOLAR AND CILIOGENESIS-ASSOCIATED PROTEIN HYLS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34174">
        <property type="entry name" value="HYDROLETHALUS SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15311">
        <property type="entry name" value="HYLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centriolar and ciliogenesis-associated protein HYLS1 C-terminal" evidence="9">
        <location>
            <begin position="213"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031570986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031570987.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35422" checksum="4C057BE476ABDCCA" modified="2020-12-02" version="1">MSEDWNFTEDEIRDKLAELGYRNIPREKLREFADDLQQLIKFESSATNQQRGTASSSTLDTTEQIDSFVSTTDEQTETSPESDKERLYPRRAAEITSKKGLSHIPYGKENYLYPIKEVDTPTSDGTSVDYERPSHKLAKKRKVLRRRNGEARVFDESFTSTDSGSTGTDISELEQRLRELPLCDPKYDNIFQQPLDYRPWEGQQAGGALPSYIRPRTSHPHTRGIKKCDPVNRYRQFSREWENNKAPGEKSHKSLRWNVRGQLLQCDIFERPQRRYVPNNYVVPTDKKRQNLRWQVRTNMARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVU7</accession>
    <name>A0A6P8IVU7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 3A4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305462</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571229.1">
        <property type="nucleotide sequence ID" value="XM_031715369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVU7"/>
    <dbReference type="GeneID" id="116305462"/>
    <dbReference type="KEGG" id="aten:116305462"/>
    <dbReference type="InParanoid" id="A0A6P8IVU7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571229.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55348" checksum="C7C31D08E8C1B12A" modified="2020-12-02" version="1">MWLILATIIVLIISLYWFGTYKYSVIKSFNIPGSTPWPYVGNIPDILKYGGIKNMLLEYRKRYGNVFHFSIGQSPMVVVADPELVKLITVKDFDKFRNRHISIKLPPPNNSGIGAAVDDQWKRIRSTLTPTFSASKMKQMVSLIDESCQVLIGKFREAADTGRTIKASSCYQQYILEVLLKTAFGMEVDFQNNPNEKIVTTVRSSFESRQYLDMFFKSLPFSSLAMKLFSQVLVKKFFSFFNGIAMQIIQQRKEKGVDAGRKDLMYLMMNTVDNEGERKLTDDEISAQSVTFLTAGLHTTSTFLSIASYWLAHYPEIQDKLIEEIDAAFAANPEKPIYDLIHELEYLDCFFNETLRFSMAAELQISRHCSQTCTINGVHFPRGTVVVLCYFLLHNDPDAWEEPFKFDPERHRGPVKEKRHPYQFHPFGVGPRSCIGMRLAQLEGKLTLVRLLREFRFALAPETKHPDGSIPKVVEIRVENRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVU8</accession>
    <name>A0A6P8IVU8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116305369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116305369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatopontin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571122.1">
        <property type="nucleotide sequence ID" value="XM_031715262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVU8"/>
    <dbReference type="GeneID" id="116305369"/>
    <dbReference type="KEGG" id="aten:116305369"/>
    <dbReference type="InParanoid" id="A0A6P8IVU8"/>
    <dbReference type="OrthoDB" id="5975249at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026645">
        <property type="entry name" value="Dermatopontin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14704">
        <property type="entry name" value="DERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027702060" evidence="5">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031571122.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20891" checksum="B491FD4B9224134F" modified="2020-12-02" version="1">MNQLKKAVVFLLLGVFVDELLGIPELWPNLGDNGHIIGLREDGGDPTIHVWCLNDKHETLKGLSSRGNYYCSSNPRCLHSFSTGNINKNSIDGRIDFVCPREGYISGIDEGYFFKDPASVEVRCCHDNHPRKGCFWVGWQNCFGRPFKFWVPDGYYMAGFRRKLHFDPKNIFSGVWDFYVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW78</accession>
    <name>A0A6P8IW78_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116305495</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571282.1">
        <property type="nucleotide sequence ID" value="XM_031715422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW78"/>
    <dbReference type="GeneID" id="116305495"/>
    <dbReference type="KEGG" id="aten:116305495"/>
    <dbReference type="InParanoid" id="A0A6P8IW78"/>
    <dbReference type="OrthoDB" id="5978972at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056047">
        <property type="entry name" value="CRMPA-like_DUF7630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24633">
        <property type="entry name" value="DUF7630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7630" evidence="2">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571282.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48333" checksum="6044512E28663E95" modified="2020-12-02" version="1">MNSRCYNCPAGGFFQDNIGHVLTTFDVFKGCKTCPPGTYVSIENAPGKSSLDCKKCPSGTKFSDFAGFRACKCLPGFYRTDRFGPCEKCPTDGVVCRNELIFLKPGFYWAWDSNPRKEAFRKLARNLEIEDDTYDINNTKYIGRLPPAYSCPVREACTGSIFSECSEGYTGVLCSVCVEGFHKSASLGCRKCSIGWISLQAVIILFFIISFATLVRKKKRRDKSGRSISEILMSQIKITIGFYQVSLGMIQSFSFIDWPENLNKYVEYANILQLNLFQVLPLHCLVPRFTFNPFYKMVMMILGNVFVIIVATIIYYFRKSRINKKDLPDEQKTAAISSAKETNYRFIIFFLFLTFPSTCTSIITVMPAACHEICSEQSCRWYLKADYGLKCFDSYYYNNYIQITLEVQHQNKAQRRSSSFPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWE4</accession>
    <name>A0A6P8IWE4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116305625</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116305625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571429.1">
        <property type="nucleotide sequence ID" value="XM_031715569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305625"/>
    <dbReference type="KEGG" id="aten:116305625"/>
    <dbReference type="InParanoid" id="A0A6P8IWE4"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="70"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031571429.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29619" checksum="7A2365BD4E8F0F9B" modified="2020-12-02" version="1">MALSKLTRKFNHWSISNFQLRNIFFCLPWKWQIRHNLTTYQDCVIKKENQTTEIDFSLIDTTTRYKILCASILPRPIALVSSCSRDGLIPNLANFSFFMPVTSDPATLAFSVTRKYNHDKKDTLVNIEETGHFVVNHLPHYIFDKAYKASKEFPSDVNEFQAVGLTPTPSKCGIAPCVLESPISLECKLFQLVQVGSGKYGSSTLIIGEVVYSHFRGVSYEDGKIDVRSLXSVSRLDGMNYGNAAISFTVDNNEIWSFKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXH7</accession>
    <name>A0A6P8IXH7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570635.1">
        <property type="nucleotide sequence ID" value="XM_031714775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXH7"/>
    <dbReference type="GeneID" id="116304968"/>
    <dbReference type="KEGG" id="aten:116304968"/>
    <dbReference type="InParanoid" id="A0A6P8IXH7"/>
    <dbReference type="OrthoDB" id="5972614at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570635.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47878" checksum="3736CF769E0B5740" modified="2020-12-02" version="1">MSFLRRQQLSTFYFFLLGLSANIIPMVVIWIAVDDILAGTLWSTTVLLIAFSITDILVKVVSPAIINRISFHLSFALLTILSVASILLLVMIDDVRVRIAGVTVFGLANGFAIITIVTLFAHYETADLLGNAFQNGINSSVFLASLGYTGLTTWFCVAPRIAIAVCIPICFIPLGIYILLDKEPLKDHLQGTAKLVQYTKLPQEEYSNDKQDTTADKPRSETFLVLVKSFPIFIYTYLSNFCIHFSIAAVLTTLTFPSSPFLPRDHFQYYRMISDAGIVIGGLGSFILGCTGQEWMNKFFGIRNTGLLVVINVIHMLFFVVASWYRFLPNVIHVFVLCFIQGITFGLAVVQAMICATNMFSSPYDKATALSTHEVGISVGRIMAAFLGVFIEKYLREHCTYNLLLGEYCLARIPSSAGWSTNLICKKQGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYB4</accession>
    <name>A0A6P8IYB4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Uncharacterized protein LOC116305127 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC116305127</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570825.1">
        <property type="nucleotide sequence ID" value="XM_031714965.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305127"/>
    <dbReference type="KEGG" id="aten:116305127"/>
    <dbReference type="InParanoid" id="A0A6P8IYB4"/>
    <dbReference type="OrthoDB" id="5990060at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15137">
        <property type="entry name" value="7tmA_Relaxin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000393">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        </source>
    </evidence>
    <sequence length="3244" mass="370535" checksum="13C651B47D2A3A17" modified="2020-12-02" version="1">MTFMYHMYGINMGTVMVYIKINGTLRPVWIKSRNQFNRWRKTTVYLDEKQKFQVVIEGIVGTSKNNAAIDEMTFTKGQCQLISVRWVHVYYKMETSHSSFKIHTSISFVYDDWTYDFSFTAKQTQTSPDEVLYFIYPEPVCTKEVASNKFSTADLKCIPIEFFYGSKRKAVGQSKILLMRRSDRLPSDGIALEGDKKCCQEAIKGFFYAKTTKFRSSACLPGWHFVAPSCIRLITTKLDWVYSNDACRRRGGKLATPKTTNEFMNYFHNYFKPLVFMGVDILYQRFFVGVEATDGHRWLWINNKETAKDFRLNNESKSSIGKCGVLLKDHSRNEWTLKAVSCNSKLSSYLCMKSASQSLQCEKGWIRANTACFRFEISKVHRTWYEARQICRHKNGLLAVLSSKSIIRSLGASLDFFVTGKQVSKDIKMFVGLKYVPDFRWTEDKEPVLNSMWFPGQPDLFKLPKSSCGAIKFTRFGWRLVQVNCGEPSGLICQQDERNLAYQRPVRTNASASFGRPTLATDGSYATCFATTKGSQPWLEVDLRKPFFIKKVIITNRRDCCFQDNELGVTLGRRGSTSQLCPMRTNVFLSKSTIFVCSQQLKVRYVTIQALKLDNLTLCEVMVTATERKQDFKGVFQEVWHHVSSYSVDKLRLDDRFPSQPEKIARIKDFDAPVYNLIYYGQSLTTYLQVPVSGEYVFYAACNDACELWIDNATESTLNEGQSLTFHSSKAKILDLYYKNFVGHNVWDRYPDKQTSLPIFLSKCNLYKLEMLMKQDSSTDCASAGMRLPNGTFERPIPMKRLFYVRPGYRNISFNFIGYDGNRIITVASNRLIDVKASYEYCCLGVYCPVCPVKVYLQLDDKVFLVNETLSMNCNTSHIFEFKLSLLKRPKSYPIKIRFSFVDEENSREQDLTVGELVIYAKTKFECNYIKDTCSWKNGNIAMHNQWNFTKGNEGYYLSASEFHTSAWLESAWIPNDEVTNVLGWCLSFYFLLPSTSQLQVILKTPSNHNGSAIWSLSGFQSKNWSIAQISWKSKESIKLNFLGKSMAVHGLGVGIDSLSLVASSCPRLPIHSEPGYKCKNDTEFQCANGQCINKELVCDGDAFCSDGSDETNCKCFSHQFSCSNGECIEASQLCNGNEDCVDGSDESRCTDEDRCDASSFQCVSGSCVPWSQTCDGDYQCDDETDEPEICGSSSCPINNMSCSALDNVTFGVECDNSNAHCDFEKGLCSLSHDPEGEFQWQIRSGSTPTQRTGPNFDHTTLNQTGKYVYIEASDKNPGKRALLLSDYLEGEEPVCIRFWYHMKGIHIGTLNIYSKRNSSRQLLWTRSGNKGDKWLYGQIGYNSTETFKILFEGTIGRGSRGDIALDDLTIAYDNCTTLDHEGQYVVCLNFIVQLFCNFDEHTCGWRNSPGWTMSRFGNRPVSHDWQQKLGGYLYLSSSGIGSWETLTSPIISTNDNIACITLWFYIYTGRKLGSEIRLSIKSKNKVKRLWINSTDTHWQYSQIPLTSNSDFQLIIEGRKTTERSLVLLDDITLSKESCDRIPKAELHHPASSLNAEKYWKLDGTDKDLRSFGFMVYKEDGGRMAACFDGKTTHLETPAIDFHARSFSITCWVKVEDPNLMSHIYSDWSHPFQFRLYAYKGFLIVVLRGRSNNAAIINLVYLHIRIPSGEWTFTGFSWNRQTKRAVLFRDQYSKQKTVDKNIKNINLRVTNHTFYEIGFKKDSGQRFRGCLRDLTVFGYAISVGEMLFRYMPSSTLCPIRQTLSGECCFFPFIFNGKLYHHCFKGKYGTWCSLTPNYDRDRKWGYCQVDAECRTVDDGWCGWQTVANISTPWKQVKDHDMRKTKTEIDNMFNSTNWSHTTNNRTNDYEVHFPKNHADYINITNIPDMTSFTICMWLRTNDTSPGTPFIYRVRYEEVGKHVLAIGLVDYTGITVFVGEHRSGKTNWKLNLGIWIHVCLRWISNDGTMHFNRENDYSRGIVYAKGEKIPGKGELIVGVTSSYARFVGEGVGQFVGDISDFNYWNWFLSNEDVNLRSVGCGLKTIPPHISWELLKSFFVGGPLVKQPATCKDSRHPRVLLNLLNTNGEYSTSTTFLSPLFPSSFTQYGLCLRFAYLIYSHVNQELLVFQHLKVDNFAARLVWAVNESGETNVWGYARASIAGVSSYKLSFQATTGNLPGYIAIKGIQVMNGYCTSKPAESHKVNSQRFTSPTGYVQSPFFPGYYGPSSTYRWHITVESQSIIRLYFVSFILEDHPECTKDYVSVYSMDLNTRIGKYCGIRHPNFVDSTGNVMIVVFKSDSNVERQGFKLLYNSRPARKRRKETCISYKGCPVGCHCSLMSSNNKWLVIKSQDTSILSAIPSDIPKETKLLLLANNRIYRIMNDFTSSARNLEYIDLSNNIITHMQESALEQLKSLKVVRMNKNFLRSLPSEAFPSTNQLSTLDLSSNLLTTIEPTFLRPLTSLRVLSLRSNKITFLNERVFEKNSNLTTLYLNFNQIEKIPELLFSHLQQLKILYLNDNKIKTFTSKMFSKLTSIEKLYLQHNYPLHLSPEIFSRLQNLKELHVDGFFLCCYAKKAIPNVKCISPKDFFSSCSDLMKNKTLQIFIWILGLSALLGNVFVVILRSIIKEDNKVHSFLLTNLAIADFLMGVYLLIIAIKDVEFQGEYFRHDSTWRTGNICKFAGGLSLLSSEVSVLFLTFITADRLKNIVFPFRSRKLNLKSARLIAAAIWIVGIVLSVIPMANLSYFYDEKRRVGYYGRSALCLPLQLSRDKLAGWEYSVAIFIVLNLISFVFIAVAYIIIFITVQKSSRSIRSTSIKRESQMAKRMAFIIATDFFCWMPVIIIGILSLLDLFHDPEQQVYAWLAVFVLPVNSSINPILYTFSTPIYKEIIKKNSAFFGSSKTPSTKSGEGTSSTQMKVKTSLQGPTSSNKTGFKKRSNTESRKKKQEPNTSEYATERNFKTHSSRKKKDKTELLTFSNVTIDDAEPDKIKEGMPFGSSCDPEAIFKVVEVPKILLEETNETTGFLVVCTKEQHCLQLMKYMHADEYSNWMKEARIASLFAKTNSKNVIKYCWHAKGEQVKLVIEENTEHVEAASLFISYEYISSVTLEDLLKDNTRSMSFYSLCAIINDLLNALKELHQHSIVHGSIFPGNILIKEYENDPPLQAFLCGFSKARIADQNNKNIHLGENIQQFGAIFETLMKQYWIVNDEINRIIEMCSEHGVITRPTEIKDIIMDTLNYQEHHITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYD3</accession>
    <name>A0A6P8IYD3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endothelin-converting enzyme homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031570958.1">
        <property type="nucleotide sequence ID" value="XM_031715098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYD3"/>
    <dbReference type="FunCoup" id="A0A6P8IYD3">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="GeneID" id="116305239"/>
    <dbReference type="KEGG" id="aten:116305239"/>
    <dbReference type="InParanoid" id="A0A6P8IYD3"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="130"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="583"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031570958.1"/>
        </source>
    </evidence>
    <sequence length="788" mass="90088" checksum="8236E079C241C9EC" modified="2020-12-02" version="1">MSRKYKMDLNSNANGVEMSDITSSREALTTYRDGRSKTTTILVVVVLILFVLAAVFIGLYTYEKVNQTKTVPAEKLNQTKTVPAEKLNQTKTDPEEKLNQTKTESEKCDTKGCVIVSAGILNAMNKSVKPCDDFYSYACGGWIKNNPIPDSKTAWSQFKILYERNEEVLKQLIFDPEIRKKHSKNEAVVKAFNYFDACMDIERIEKLGGKPLEQLIKDYGSWNVTDKKWSANSWDFMTNFVKIQKELSIALLFNMFVATDLKDSTKNVIVFDQNGIGISRESYFFNTTYHKKVRGAYKKFMVNLMRLVGAGDEAQARADEVYAFEKELARIFIPKEQRRDSNAIYKKMTLKKLIEEIGPSQINLTEFLVRMFAETSYNITQDEEVVVYALDYMKNVSKVFEATEKRIIANYLMWHVVVLNGAYLSQEYTKVFDEYRKSIMGTSGEDPRWQTCMSEVQKAFGMAVGLLFVDKKFSGTSKKSAEEMIHAIRGVFIDNLKDIEWMDEETKKAAKDKAEAIRENIGYPTYIVNATKLAKEYKGFDVNKTTHFQNNLNRKRFDNMKNYQEIGKPVDKTIWSMTPPTVNAYYSSSDNKIVFPAGILQDPFYDESHPKSLNYGGIGMVVGHEISHGFDDNGRKFNKDGNLKKWWTNGSIKAFEEKTKCLVEQYSNYKFHGKNLNGLQTLGENIADNGGIKQSFQAYQIWKKKNGKEEKRLPGLDLNHDQLFFLSFAQIWCSSFRPLAAVSAVENGVHSPGQWRVIGSLSNSQEFAKAYKCPVGSRMNPAKKCKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZB3</accession>
    <name>A0A6P8IZB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein bark beetle-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116306862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572846.1">
        <property type="nucleotide sequence ID" value="XM_031716986.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116306862"/>
    <dbReference type="InParanoid" id="A0A6P8IZB3"/>
    <dbReference type="OrthoDB" id="5978034at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027834705" evidence="11">
        <location>
            <begin position="20"/>
            <end position="3304"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="984"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="1876"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="12">
        <location>
            <begin position="2225"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3271"/>
            <end position="3290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3271"/>
            <end position="3280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1946"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="15">
        <location>
            <position position="3075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031572846.1"/>
        </source>
    </evidence>
    <sequence length="3304" mass="371576" checksum="F0ABAD9FFEB1DC34" modified="2020-12-02" version="1">MKLGQVLFVLFLLTQGTATFRSDAIAPSRNYTLLSTVLAGELVGNITLTPSQGPFVIDKDLLVPEGSQLTLKPGAQLLFRPETGIRINGSLVAEGSPENKISLSSFPYPNASSYASYYYGNGIRLVDGNNYTEGRLEILMNNRWGVICADHWTEKNTDVACRHLGFLGGKRHFERPFDRTKLYLIDYFGCKGDENNLWNCNYRSRWVNCPQYPIGIECVGLQSFLKEKVKWRGISFMMQSPGVLSILKHVTIEDAVFALNVTHQAPEISGVTITNSFHGIQVSHLIEQSNIELTDILVHDNYLTGMKIMSLKSEVRIRNSSFTTTSFGDGFSFEDETVPIDLCTWXQNSTLVYPLMFSASSDGNDGYCSKRGVNIENFAGHLQMTNSKMNQNALDGVNIKGLVGKLELIDLDVVNNGQLGLVLEXVSGKIVLESFNISHNKQDGVKVYQGTGFLMMKKGAIKENNARGIHIGSLREVQLNLTSLVISMNKETGLTLEKISKGILMLTDVTTTLNSKYGAYFTQCSSPVAIARSSANENGGHGFYFQRQGGSVKMSEFTASRNQESGLRVEDGISRLFIQHGMINKNNKHGFYLNNHGGEILMVNVSLNDNKERAINVYENSQGNRITLFSVYGCYISGSKVGLKLIIXCTYKSNSVRNVSIRLESNTFANNTLETFGFYKEHTCYYSTTPRQVFIDAVNNTFILNKKSVXHIDCPGMFALQGTLASNAFLXNLGKVVTVREGTNCXDRHKYPIXXQIXSNRFENNTGQYMVNIDLQPWYTIRSXVLRHNSFVMNKQTKLPSRFYSRMTXDAVIVLKEGTFHILQNSFENPNFNYQVAAALVAHGRVINASHNWWGTKDECRIKDLIFDKEDRLDLVKADYFPYLLSNHSSDIISSNTTRPLCFLKDSHLGGTLNRHLILSNKSVPYKVVNDLVILPKGSLVIESNVTLIFPPRSAFVVQGSLNIYGEEXATVKFTLDKVVDSRIRLKNGWYGNLEIKINXTWMTXCVXRXFXFQPEMVCNHFNLEYESYNXYYPSGKEHGFINNLNCDHNIALDMSPCNYENLXYTPRCDXYVLYLRCKRPYWSGVHLAMTKAKNSIKHLEIHEGGQNYRTDLKITSAALRVDFDDHVLRNIMVKNSASVGVQVLYSNPFKRVPTLSSSLVEGTESNGMQISFSHAPLDRVNIIDAKGNGLYSKSLWNDLDLDARRMSDPAFIHHVSDCKEKSIFIQEGDSRYLIFSPFGETAPSSCDQEVYTTNRSNIALQIIYKNIRYSSYHYDSVNVNSGGKQWKLEDLSWEDRPVLYANTSIMHLRFMKYYAYRPMLVHLLASSLNDTNGHMKQYKKISIKNCVIKNTSGSGIYIHGPRTESIVIQNSTIQSSLKNGIEISSSITSLFVQSSTIALHLTGVLLYSLNGIYNKGIAGKIFISKSVISKCSNKGLHAWASGSKTITIEDSLMSQITGNAVNLYGRYSQTSLYVNKCRFHENKLHCVNAHSQNNWGSAIEFHVTNSNFSNNAGRVVNIERATSLAKWLIEGNTFFNNSEPSVISIGEHFPHTTYTIKNNSFISNRCNKDAVIDLCYSAQFVAIDKNTFLGNFGPAVILKTAVASLPLQIKENTFINNLCFGCPILKFLRIEKDLILENNTFTNNTGQVMIFLQAAYEITASTLVQKLSLTDNAIKESHPSASVSSNVERCVINFNGILFFKDVKWRNNKMSNAQFDFELCLHTLGLSQLPQLNANETWWGTNEDISRRVLSFDINYEYGIVNYGHFLALENKVLKTIVYDADSAFDELFGKSILRGRIHKSITLRRNNSPFKVLGDVTVLPDTVLTIEPGVTVQLAPYASILVLGKLIARGDKEHHITFKHIDKSKNTEALPFDIRLMDGDFPWYGRLEVYHNSSWKPLCTEKWIRQNVIVACRQLGYDGPNLDMSPIRFGNTENNLTYPLELRCLGNESSITKCANNSTGQDIHRCQSVVGLRCHGKEWGSIRFSRPPIEKINASNSTSVLEYVDIMYAGKRKSSNTSAIEMIRRVPIISHIKVFNCSSGGLTIVLPDKNHKVEKSQFINTGGTGXTVMENTKSFVIQDSHISENNNGLLFIRWDDQLISNFIGQDGVFLCDNKMQTIDVKESEFLYFVTTPAKGHTKDYPTIECQKRLRTEKGMGIIIRVLSVKGTQTLRVHVGQTDIINTKTYXWKGFNLYIDFEDVQLTWKGTFSSQVVLLVTAIELKDMPCTFIRNRMCGWQSVLNKRVLGMTANNAFKNVYDAGSGHAIDLQYPYWWREHYANLVSPLITPNAKACQLNFEYSFTSVQSYLWLAVIREEYENGTQIHTKLWSSDEEETQKRXWMKTSITIPLRNKPFRLVLFAHTKKTSWYNTNIYLKNLNVKNCSAENIDVNGNFFTKNRNHNILLQSNVPIQQFNIKIHRNKFTDAVDDASTTGTIRINTYNNPFYILNNFISNNNNGGVYATVGNSHGNLVIKSMIERNYFEGNKKETIYIDAGYGGKAFNIDIFGNNINGNNGKGTGQAIHSNIKLSQVVCTLEENFVYDNYGRYNLEIMLNKRTIVNRLIKVRNNTFYHNHGLIKDYGSTMYCNGSVVIYKNIIKNPSNLYELVTDRASSFRLINATSNWWGFGSPNIVGMRIRDVSDDYKLPTVSYHPYIPLRPPTAVPLSCPAAGWILFEESCFLYHGGPMPYYEAEKYCLGRACTYSYCTQFENCRSCISSKNCGWCDNLGQCLPGHGGRSYFGTCQDWFFYNCYTMGRISFCSRRQITLLDCNRQLCNRFSDLASKESCQRCKDHENCFQTKDAEGCRTWNETRCPNGQVKIDYSDPTRVDNTQMNGNARSISPEEVTMYRCEAKEPDGRVTTVFAFNANLTLNPGNVISSNQAGGVFHKVSNVKDFVSNQSHGFLSTITSINKTSEFVFVETLLLRCDNTTDMSFKFPSKQLSDEDLSCPGGDNNPNLLIKATNNETLNMSVNDVIVDRPSQPFVAKAKSFHYSQGYLVVEVLPVTSIVNEKAITEIGIDEPLSHVRRKRAIYHRFFGANGRWGFTLKQGGQGFSSFLSYGVGFSLILQLEVSSASIDKLKPPKVRMNIFMSARASASAEVSFNLNRGGSASSSRSLVRGLALKRFSICIYFLCIPCGIFFDLDASGSVSAQLAAVGSAFYQLRISKEMANGECSTTGRCQSSLSKEIKERSPIKSLPTINLSLEIPIIVESKLNLCSPKCHPLGRKGLKVKIGAPKIVFSITIGEKNKFSLSSGRIGQVINEYCFDIPPHDQTCRPTEKPDPPETGFGNDENPTMDWENVGILLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZE0</accession>
    <name>A0A6P8IZE0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116305388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571155.1">
        <property type="nucleotide sequence ID" value="XM_031715295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305388"/>
    <dbReference type="KEGG" id="aten:116305388"/>
    <dbReference type="InParanoid" id="A0A6P8IZE0"/>
    <dbReference type="OrthoDB" id="5989569at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571155.1"/>
        </source>
    </evidence>
    <sequence length="765" mass="83584" checksum="726CFFF3F7E5A185" modified="2020-12-02" version="1">MKSLLVKITERNTDTYWSWVVCFSSFFIQVLVIGLQNSFGTIFVSLLDKFGRSESATVWVGTTAIGLTYFCGPLSTYLCKRFGCRIVACTGSALLAISGFLTSFANSITTMYFTFGVLNGIASSLLFFSSLGALIEYFYVYLPLASGISVSGSGVGTLIITLLLQQLLSRYGVKVAFQILAGMSAFCFLAGLSYAPLKSSKESNLKEPINDFHEKTLKQIDSNDGKQNIRGCLRLFKLGKHWKNKGFVVWTIAMTLIMFVCYIPLMYLVLIAEDIGVPPSKGGXLISIFAISSTTGKLLVGKLSNVKCANRLWIAQTSLLLMAVSTCLLPLAKSYSALVAYCVVQGFFDGGYTVSIGLITNDIVGKELMAGAVASVYSVVSIPMTVGPVVAGVLYGHLGDYNAVFFLSGGLLLTGMTIMFLIPWLTPPTLXKPNLEQDLTTVKSKAFGSFVNGNRYDLSCVDEKHMANLLDESVAHHLLKRNRAFLDGSTSDSQRSSFVLFTIVSENDQRDISAYSSFQDLALSNTDTGPNFSNSLRNFFHGSHSSLFSTNHSVIEAPHLESIPEVLFDSRASETCVLIHNEGTLETVRESEEKETVKTFVEEEGEKTSITNIDIEVTDSLDNYNHDYEDSRTKETDVSDKVPHEGIAEETFASNLSTSDLSCDSNKSSSSQLSTGTADSGFVEGENNFLNKRSVSSSSDRLVRKPSLYKDIPFHSYSCTDVSLLSQAEGTNAKLHKTNLSQDLIDRCQSEIDGIDSYSYSETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0D3</accession>
    <name>A0A6P8J0D3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tachykinin-like peptides receptor 86C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572904.1">
        <property type="nucleotide sequence ID" value="XM_031717044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0D3"/>
    <dbReference type="FunCoup" id="A0A6P8J0D3">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="GeneID" id="116306909"/>
    <dbReference type="KEGG" id="aten:116306909"/>
    <dbReference type="InParanoid" id="A0A6P8J0D3"/>
    <dbReference type="OrthoDB" id="5967581at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004977">
        <property type="term" value="F:melanocortin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000368">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001671">
        <property type="entry name" value="Melcrt_ACTH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00534">
        <property type="entry name" value="MCRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572904.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35893" checksum="A778A4EB552367A7" modified="2020-12-02" version="1">MSSLNTNNTAVNTGVTVTLSALIVVDLIGNTLVILIILTNKSMKSPINYLLVNLAVADIMVGVFLAPRFILNQFYIHPDGFAGKMMCSFLTGGNFSWVGAVASSFSLVTICCERYEAVLHPFASNRNMSKKKSRAIVVLCWTIALVLNVPLFLTKIYKTNDKTCGSLWPKEHPWFEATYLISWSVIVGIIPIAIMLVLYSRVIYSLWFKQHQVQGTQLAVLKSRKRVTKMVVIVSVVYALFCLPDFIIHLLIFSGNTNSSFKSIHLSFIILMVCNSAINPFIYTLQSGKFRRHFKRIFCCTDTNKVFVDVNISLSAAAHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J104</accession>
    <name>A0A6P8J104_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031573164.1">
        <property type="nucleotide sequence ID" value="XM_031717304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J104"/>
    <dbReference type="GeneID" id="116307152"/>
    <dbReference type="KEGG" id="aten:116307152"/>
    <dbReference type="InParanoid" id="A0A6P8J104"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="110"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573164.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37759" checksum="C34FC9E2E4EDFA9A" modified="2020-12-02" version="1">MTFPLDIGSIVGYSGRKRDSEIFYKFESFLTPGVIYHCDLSEKELTPKVFRETKVNGFDPSLYETNQVFYNSKDGTQIPMFIVHKKGITMDSNNAVFLYGYGGFNISITPSFSVTRIMFIHHLGGILAIANIRGGGEYGETWHRGGMLANKQNVFDDFQCAAEYLIKNKYTSPKKITICGGSNGGLLVTACINQRPELFGCAISQVPVTDMLKFQKFTIGHAWTTDFGCSDKKEEFEWLIKYSPLHNIKVPDNGVQYPAVLLLTADHDDRVVPLHSFKYIAELQHTLGGVKHQSNPLLIRVDTKAGHGFGKPTAKLIEEYSDIFSFIARNVGAKWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1M4</accession>
    <name>A0A6P8J1M4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide receptor 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571655.1">
        <property type="nucleotide sequence ID" value="XM_031715795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1M4"/>
    <dbReference type="GeneID" id="116305825"/>
    <dbReference type="KEGG" id="aten:116305825"/>
    <dbReference type="InParanoid" id="A0A6P8J1M4"/>
    <dbReference type="OrthoDB" id="10053542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571655.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30602" checksum="598CFF3959092D11" modified="2020-12-02" version="1">MLYKNTTNFSFNAFLNESRCNSSSGSCSPVQTCPGTVVHLAYISVIWVIGVLGNILLLYVDYKEWKKSKTPDKLLILNLAITNVAALLVSLPLHAVLVANYQDYLKCAGSLFQYRSARFFLICLFNFVSLGTLLVIGIDRYQALIKFAHQRTLDLKRSIFAICLVWLCSITVVVVFIVTWPNQCTDFYSSRLEDRNTDNYYPMRITIISIWITVCCTVTGRSLLMAASRIRKQQQKIKTMFGPVQAAAQISFTKGVIGLLLCYVVLWIPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2E3</accession>
    <name>A0A6P8J2E3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Trace amine-associated receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116307629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573762.1">
        <property type="nucleotide sequence ID" value="XM_031717902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2E3"/>
    <dbReference type="FunCoup" id="A0A6P8J2E3">
        <property type="interactions" value="798"/>
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    <dbReference type="GeneID" id="116307629"/>
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    <sequence length="261" mass="29875" checksum="F18B2877466BC667" modified="2020-12-02" version="1">MGFSFLVASVLLFPCFSLTGTVPVGEIQTPEFALEQKASVTKFTEFHILEGGSEFDESIDIDEKKEIEHFKVPSHNGLSESDYLYDFKMNITVRRVKKDGFCYITPLPPALPRPNELSKKLNPLSGSSATHKIEKTIQQWRVGARVNQSALRQAVRDFCGQFPIYRLEPFTADSISVMAEDHQYTRTDRKRRDISNWPLCNRPFPTNCHPNTWLFTCKIRSKSCVYYVTCEINVHKNVLQCRDLNKHLCNTSILCCSPKCP</sequence>
</entry>
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    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574271.1"/>
        </source>
    </evidence>
    <sequence length="863" mass="96306" checksum="7CD0C22095DC6815" modified="2020-12-02" version="1">MTMADQDINIRLEGGGPWGFRLTGGKDFGSPLTVSKITPGGKASYNGLREKDQILSINYEDTRNMIHIEAQEAIKRAGSTLDLSVRRGDSPKIGRAPLTKTETLHSGKVDHKYNAIPKPFGATSYQPPRQSPASPSGAQPAPTVRSGPPQTAPKPSSPMAPAYSHYTGGPPRNTGGPPGRDFIDNDAAMRAKKKEIEEEMLSQRFKLSISDDGEVNYDEASQVPNWGNPPDPNVQSKSFKMLQRHLQQHEDDDLPPPPPEAYDVDPDEGKVQSKSFQMLRSAVDSGETPPSVFSRDRGDRTKPSTTPMPSRPTVPIARSTNEPSYAPPPMSRPGQTPPVALPGMARQEPLPQSSPPKIKTQRPQAPSVHNPSHPPSAPQPPRAPAYGGGQHQEIKRQPIKPPQPADGSRTPYCDACGQEIFGPFVSAIGRSWHPDHFTCAGCGDSLQNQGFIEEGGKLYCEKDYNKHFAPQCNSCKQPIIGPKSLHACVFPKSTPQSSVPVPSSDMLKAIRQGQPTAKIXRKPKINPSLVTHKKSLSESNNYGKVHYPIHGIDYMSRRDSSHSRSRTSSTGSSDSGNVFRSRSESSSDQWEPLVSPRAVKEFEKLHAEMTYAEPGSGSMKDKVKQLKEQVRSAIQQEKDANEAKEVAAQRYKKSKILSNELKWRIQDAEDKLQRLETKLENTRGRLYERSRVVQESLGNKXRAEHVTKENIREKENIEYEMTEVNAARDSALNRLREVSRRLAVKQAAIQNAEDHFNAMNARSKMLSDMKEMYKLRINNIHSRSSQLSMRNEKQVHRIHIVEDSIAECTERFKRAEKMMLPLKIYLNQLQDAVTEEKSNTRRLSYELAAYQQRLRAARHYTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2U9</accession>
    <name>A0A6P8J2U9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116307744</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573904.1">
        <property type="nucleotide sequence ID" value="XM_031718044.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J2U9">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="GeneID" id="116307744"/>
    <dbReference type="KEGG" id="aten:116307744"/>
    <dbReference type="InParanoid" id="A0A6P8J2U9"/>
    <dbReference type="OrthoDB" id="5961910at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042803">
        <property type="entry name" value="TCF19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15464">
        <property type="entry name" value="TRANSCRIPTION FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15464:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573904.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="42706" checksum="1873B8D4B1B82125" modified="2020-12-02" version="1">MPLNTASDEENHVKFCLKRTGAPATCPNISNVFLLDKGTTVVGRNPSXSDIYLDSNIHKGLISRLHARISVGFDNKVKICDTSLNGTYVNDRKILDTVDINPGDTITFGHVKGAVLVPGTVAKQLTSEFRFKLEKYVGNPVHDLTIVSAKENSPANKKTEIQGFIPNLSSFXRNEKTDTEDPIERRAADITSNGTADSITSTADSDILAYNNXNDDELLAFAAAAEDAMEESDTELFSVSLPSPSSDNYTSNXSMTMSPICSSLENMDGRHXDNPCTNITSNLVHEKVISGESTHEKASKQGKNSKRSKRKSSTLSSKKRKHAKPNNSYEKPVPDMCSFGSDCLCPHEQHEIVNWVQCDYCQKWYHLECAGLTIDTVXGKSRKFNCGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J493</accession>
    <name>A0A6P8J493_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein ATP6V1FNB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572828.1">
        <property type="nucleotide sequence ID" value="XM_031716968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J493"/>
    <dbReference type="GeneID" id="116306846"/>
    <dbReference type="KEGG" id="aten:116306846"/>
    <dbReference type="InParanoid" id="A0A6P8J493"/>
    <dbReference type="OrthoDB" id="410807at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054323">
        <property type="entry name" value="SPMIP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35826">
        <property type="entry name" value="PROTEIN ATP6V1FNB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35826:SF1">
        <property type="entry name" value="PROTEIN ATP6V1FNB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22589">
        <property type="entry name" value="SPMIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sperm microtubule inner protein 1 C-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572828.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21447" checksum="CC9C61445A26FB6D" modified="2020-12-02" version="1">MVRELNMDTQRQNFWKESVEKEAMVRLMWHTRYSKEFSRSTFVPKPRKEGMVIKSAEGIKLPALNNDEQKTSKTDIQEASKKQFGETAKENPDALLVEMRPVSKNTKSVLYKGFSALGEGRYAYLQKRKLKKPEEKYEFPITSAWEIGWKINEYIPAIKNEQFGRTHVIRDSFYRPNGIFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Q5</accession>
    <name>A0A6P8J4Q5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-tetrakisphosphate 1-kinase</fullName>
            <ecNumber evidence="8">2.7.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116308392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12452"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57539"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.134"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8 10">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ITPK1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.134" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031574662.1">
        <property type="nucleotide sequence ID" value="XM_031718802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4Q5"/>
    <dbReference type="FunCoup" id="A0A6P8J4Q5">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="GeneID" id="116308392"/>
    <dbReference type="KEGG" id="aten:116308392"/>
    <dbReference type="InParanoid" id="A0A6P8J4Q5"/>
    <dbReference type="OrthoDB" id="25308at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000047">
        <property type="entry name" value="Inositol-tetrakisphosphate 1-kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041429">
        <property type="entry name" value="ITPK1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF1">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17927">
        <property type="entry name" value="Ins134_P3_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038186">
        <property type="entry name" value="ITPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol-tetrakisphosphate 1-kinase N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="11">
        <location>
            <begin position="134"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="292"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
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    <feature type="binding site" evidence="10">
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            <position position="306"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
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        <ligand>
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            <label>2</label>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
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        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031574662.1"/>
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    <sequence length="338" mass="38282" checksum="E5BDD744984FCCC0" modified="2020-12-02" version="1">MSSTTKQLFPLSMGRKRVGLLLSPKKKRKSVFDSFIELCSETGIELIEIDLNIPLEDQGPFDIILQKITDYMAQATDGDEHALKTIQSLEHYLDCHPEVKVLDPLDCVQKLCNRLVSYQVMKQCEFIEDGIRTYMPNFVRIDSTDLDENIRRIRTANVQFPMVCKPLIGHGSDQSHRMSLLFNEDGLKDVTPPCVVQHFVNHNAILYKVFVAANHYHTVDRPSIKNFYKKKDNQPTIFFNSHDVSKAESSSHLSQLDEIDNTGKATPTDEVVVAKIVNKLQNELGLSMFGIDIVIEKGTSNHVVIDINYFPGYEGAPSFPADMVNYINQILFTDQNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4X0</accession>
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        <submittedName>
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        <name evidence="7" type="primary">LOC116308424</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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        <lineage>
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            <tissue evidence="7">Tentacle</tissue>
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    <dbReference type="KEGG" id="aten:116308424"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:phosphoprotein phosphatase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUAL-SPECIFICITY PHOSPHATASE 11 (RNA_RNP COMPLEX 1-INTERACTING)"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
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            <end position="191"/>
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</entry>
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    <accession>A0A6P8J5K6</accession>
    <name>A0A6P8J5K6_ACTTE</name>
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        <name evidence="5" type="primary">LOC116309025</name>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="154"/>
        </location>
    </feature>
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            <begin position="356"/>
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            <begin position="799"/>
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            <begin position="367"/>
            <end position="417"/>
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            <begin position="846"/>
            <end position="861"/>
        </location>
    </feature>
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            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6N6</accession>
    <name>A0A6P8J6N6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116309049</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116309049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575439.1">
        <property type="nucleotide sequence ID" value="XM_031719579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116309049"/>
    <dbReference type="KEGG" id="aten:116309049"/>
    <dbReference type="InParanoid" id="A0A6P8J6N6"/>
    <dbReference type="OrthoDB" id="5984732at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031575439.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28275" checksum="31B34E0180DD37B0" modified="2020-12-02" version="1">MALLGHHGGSDVDEVIEKVLNSDDVDEGVENEDKEEKDDVEDNIDSWLESFSAPQAFNTKLFRDLAKEVLKPIVQQCSVXCSHGELQPSERSRAAQYLCTATLNANSILYSEALLXLKRIFTRLGGRVEFKQPYHGKTSRSIPYDVFKVARRVVSENRDGSFYEPRCYIKHNNKAEIICFTSLYSFKKFMSVISGLSIKDVQQYLCRELSSKGREHHVVKLLVEEEKQLALTYWIKKGQLDITFEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JES3</accession>
    <name>A0A6P8JES3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308573</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574900.1">
        <property type="nucleotide sequence ID" value="XM_031719040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308573"/>
    <dbReference type="KEGG" id="aten:116308573"/>
    <dbReference type="InParanoid" id="A0A6P8JES3"/>
    <dbReference type="OrthoDB" id="100767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZU5" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574900.1"/>
        </source>
    </evidence>
    <sequence length="1517" mass="172544" checksum="3402A84FE5A176C9" modified="2020-12-02" version="1">MAPNVEPCLQEFSNCFSESAATKANDTIKRSLSSDERPQDSIETQGSIDTQEILFENLKKFHESGYIDISDGETKLLEMLAEGVLADEKTGKKEQVVNLIQSYKSQFPIQEKIFGREKDMKKILNFLSNPRVPGLNLFGESGVGKTTLAKEVSKNMKEFVTLSIDLRGTQDINNVYFKVLESFNLAKSDYNKERIYTHLQNLTNRTLLLLDNVEQFMSKEKEADQEARSKFLEFLKAITVSNACKNGHLKVLLTSRIQIDEQELKHALFVEYKLEPFSKKESTEYISRRVKDADSDQRQEIAXVKISDHCKDIIYLLRAAEQLKREQYSTSLQVLEKIAAQIEKGVPEQFACISALFESLPNDHLKQIAVKISLLQRPFSVYTAMKVIEMSSEYDAKWDLELLVTQKIITAEDVNGERKYDVHDRFREFVALYLCKEDPVSQEHLSKGKEKFAENFSDELVKLSEKLESDFVVMFKMLEDNRPNFEKTIDIIIEEESFDLLFYSDDLKKAGLLSLLFKYVVNNQKRRELFKSWSENSEKKGNLLISAYIKCWEALLSAEMEGISRGFITLNQAKRFLDQVHKKTSNQGLFDMTRGMYLFSKGHLKYQEAGNLTDQSSSETKKMTKRILKEALSDLEESLVIHQKVYGDHSLTARSLDLMGNCYMQQFEPEKAELFYQEGMCMKLKLIGSEKHDDIVHYYNQLSQVHQMMGDKIMKGPFDLKKVMGPLLPYQRRAKKEYEIAANLLKLALDLQENLGVCDTEDTATFQRNLANLNIALKNYDKALEYAEKSYKTRYCLLKEHPETVRILYLIGIIHEWRXDHKAALASYEEAFVMEESLPEDNHSXVRKLLCDRLEAMCKKLNKKNKLKEYGPRIKAMKQIKSSQPHPEEPAAQVSPTTRGRDEQHLETAEEPTEEEVSDYLIQGDITEETPLIYTEPGVADAEHPVQEDLPGLPLPPDVTAVTPTEPGIADAEHPVQEDLTGLPIPPDVTAVTPTEPGIADTEHPVQEDLPDVPLPTDDTPVTPTEPGIADTEHPVQEDLPGVPLQPDDTPVTSTEPGIAYTEHPVQEDLDISVVTGITDEIPPQCITINPEGGILDIPMIGIRLDIPPNTVTQATTLICKKYTAESLLVTFPAGKDETVVSYIVGLEPSTIRLNKPISVSLMHSGPGKEYGYETIVKALSQDNETWQEPKVLDRRQVKESADCRKDYVEVQIGELTILAVVTRLITDRFQVTPKGCVVRSSVCDDVTIEFPQGAVNKTVEGTMKLILVDYWKKENGYPLPILCVDGFDDVHFKKLPTIKLPQPCPEKYSESKICVLCLEDSKTLSKNESQWKDITEKIHIEENEYSIQLHVTHFSWFSGWKWKDIPPITYISSAYEYLYSPPTTVCFAAFKITGDSFNSFQLGLLCVDNTRLEELQVNSQLSLKTGEAMRKNEKAYVQIKGDFKQDESDAEPVFLCFLGKKVYKNDVYICKRGGIYKDGEEMLKVFFHAENDEKRHLCKLSHKAKDIPSPPIWSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GWW1</accession>
    <name>A0A6P8GWW1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116286373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116286373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548739.1">
        <property type="nucleotide sequence ID" value="XM_031692879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286373"/>
    <dbReference type="KEGG" id="aten:116286373"/>
    <dbReference type="InParanoid" id="A0A6P8GWW1"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027535624" evidence="3">
        <location>
            <begin position="21"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="209"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="311"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="374"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031548739.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57162" checksum="AFF9F5E235719C58" modified="2020-12-02" version="1">MVTTRFFCLLFATFFVVTESLEKASCPRPLNIVFLLKTSKNFNIQTLVAAKRLIRQTADSFQIIPRQTDMAVILSGPSATVAVQFGQNDTNHFKQEVDKLGLSKDEQSIVSYDGMFDRAIPYAGRAVVVMTTGEDNEIDDPIFIEAVKDMKVSNTSHVFVIQLTEGQDIRRLLDIATDYDLIYNVKDLLRNGKQQXKFHFQICSTLGDLRLNGTSLNRGCLEVYKNKTWSPVCSPTWNNSLTDIICQRLGFSVNVSIGNDSDNSLSFLGKGSXGLENSSIEYGCETIGGSNAYKNCSRRPSCRHIVCKVPVRISGSPSRPHIGLAEVFFLGTWGTICSDTFXEHSANIVCQKFGYPVKSLMTFVDVSNDISSLPTMLMSIDCPVEKGQLEQHCNLIKCDRKCSTTCKTRPASVLCDTSKGEATETITITRTTGPKIIIPCAMYTVMDVKWYYENGHERREIIMTHNASRIKFNNKDQKESRLTIRKILLNDGGAYFCESGSSRKMTFLFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1B0</accession>
    <name>A0A6P8H1B0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 18 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550189.1">
        <property type="nucleotide sequence ID" value="XM_031694329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1B0"/>
    <dbReference type="FunCoup" id="A0A6P8H1B0">
        <property type="interactions" value="2235"/>
    </dbReference>
    <dbReference type="GeneID" id="116287645"/>
    <dbReference type="KEGG" id="aten:116287645"/>
    <dbReference type="InParanoid" id="A0A6P8H1B0"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="10">
        <location>
            <begin position="44"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="626"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="11">
        <location>
            <begin position="859"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550189.1"/>
        </source>
    </evidence>
    <sequence length="975" mass="112182" checksum="1DDFAC6ECB0FB7D7" modified="2020-12-02" version="1">MASILDQYEQAATGGADSLNPFLASDDIEPVSSGFIEMQSDDIPIFRRQKINFRPPSNIADLVVCNNTVVVALSTNFIMRIDLANTNEIDTVELSRRMDDTIYKIFLDPSARHLIICMNSQESYYLARNSKKPKLLTKLRGHLISAVAWNKSKLTETSTQTILLGTTKGLLFETEIEPEEKFFQGGIERFLKQLYDVNASGEKEEPTCGVMFEKLSSQDRKYIIMVATLSRLYQFIGDVSNGETVDFLPMFTEYENAPAPFHEMPGNLEHGELRFFYSKFRGAPSSFAWLTGSGVYYGKLTFTPNEKIDNIITESKLLLYMPSGESKVPVPPLAIGLTEFHALLLNKDRFEAVSLLSEETVFEDVMPPRYGVMRGMSIDMAKKTVWIYSDTAIFQYHVTRESRDVWKMYLKKEDFERAKLYCRDNPANLDKVLTKQAEDLFQKKNYTAAANCYAQTQVSFEEIALKFIKVEEKKALRMFLMKKLESLEQKDKTQMTMIVMWLIELYLNRLNQLKDSSSSNPSEHDKLQEEFRKFLATTVVKSCLDQNMKTAYELIASHGDVENLVFFAMLMQDYDHVISHHIQHDDYPAALNVLTRQTDTELYYKFSPVLMQHIPKQTVSAWIEKKGALNPKRLIPSLVHYHQQGTSVQLEEAVRYLEFCIERLGNQDQAIHNYLLSLYVELKDDDSLLRYLQMQGTHPDKVLYDLEYALRLCSEHSKHKACVHIYSTMGLYEEAVDLALKVDVELAKLHAEKPAEEDEVLRKKLWLRIARHVVEEDRDVKKAMEFVNQCTLLKIEDILPFFQDFVTIDHFKDAICSSLQEYNQHIQNLKNDMQEATESAKLIRTDIQDVRNRCGIVPANEKCSICLYPLLTRSFYLFQCQHAFHTDCLVNELSLLLKEKQRAKALSLYSLIYSSDPAYGETPPGNSDQSREALKAELDDLIATECVFCGDLMIKTIDQPFITNEEYEQVQASWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2V7</accession>
    <name>A0A6P8H2V7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LOW QUALITY PROTEIN: laccase domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116287254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549776.1">
        <property type="nucleotide sequence ID" value="XM_031693916.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H2V7">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="GeneID" id="116287254"/>
    <dbReference type="KEGG" id="aten:116287254"/>
    <dbReference type="InParanoid" id="A0A6P8H2V7"/>
    <dbReference type="OrthoDB" id="10055554at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="entry name" value="CNF1/YfiH-like putative cysteine hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616:SF2">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE LACC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YFIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="CNF1/YfiH-like putative cysteine hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF218" evidence="10">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031549776.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52144" checksum="1DD693F12DA4C4C3" modified="2020-12-02" version="1">MTTTAATAAIIVLGCRINPDGTASAMMKHRVQEAAKVYQSLLNDDKSHPWVIFTGYQPHGDDNKKXTEAKAMSSYNEEEGLIPADHTVLEEKAETTAGNAYWSRVIIDDLGIEEVHVVTNEFHVKRSKVIFEQLYPSETYKLYYHAAEQQLDDETQKRSSEREEKLMHQIDFDISEVVRKIKESPDGKPITILNSPIISDEVFNHGFTTRFGGVSTHETLSSLNLVXNPKRXDPLVNIMENRQRLAHACKYMPQGFHMAKCVHGTGVWVVGDEEPDSYDALVTNQVYVTVAAPGADCTIVLFCDPINKICGAAHSGWRGTLAKISHAVLDVMTKRFSCQIKNIYVAVGPSIGPCCFEVGEDVAEQFAGISKDVVVRKENAPKPFVDLXKTTRILLEEYGVKPENIDDNTSKIDGVEESQRVTQCTYCDQEKRFFSYRRDGAQYGTQIGFISAVASSQNKDSKGKCRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3J6</accession>
    <name>A0A6P8H3J6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 143-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116287486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550026.1">
        <property type="nucleotide sequence ID" value="XM_031694166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3J6"/>
    <dbReference type="GeneID" id="116287486"/>
    <dbReference type="KEGG" id="aten:116287486"/>
    <dbReference type="InParanoid" id="A0A6P8H3J6"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031550026.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21674" checksum="4FB47C8D0481C239" modified="2020-12-02" version="1">MAGQENICDFKSCGKKFKKLQRLIEHKRTHTGERPCLCPKCDKTFVREMHLKRHMLSHNGTKSFSCMHCKLMFTTKHYLKRHIDRAHNRPFKCPYKGCKKVFKRCNLLKIHGYTHTNERPFRCKERGCHSAFNTPGKLESHKKLHNLGFHNYFPRVRNDKIAHRWLERHVKSHNCLIFCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3N2</accession>
    <name>A0A6P8H3N2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC116287529 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116287529</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550070.1">
        <property type="nucleotide sequence ID" value="XM_031694210.1"/>
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        <property type="nucleotide sequence ID" value="XM_031694211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287529"/>
    <dbReference type="KEGG" id="aten:116287529"/>
    <dbReference type="OrthoDB" id="10065153at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cortical actin cytoskeleton"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:site of polarized growth"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Drebrin-like protein isoform B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF23">
        <property type="entry name" value="CORTACTIN, ISOFORM A"/>
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    </dbReference>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="144"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="412"/>
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        <location>
            <begin position="354"/>
            <end position="379"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="389"/>
            <end position="401"/>
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            <dbReference type="ARBA" id="ARBA00022443"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031550071.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="51412" checksum="991ACD119EC1C3C3" modified="2020-12-02" version="1">MIRYANIKSWNVRNVYKLCSDICSYCTKTMTVLKRWCHVPTAVEVQKPDKSTRLKDMKRSILISMLSMIDLDWHMENECAKTILDCPFKDQGCSTQIERQHVDKHVQDNMAEHMLLLAKKFSLLTKDNKQLRQELNXLKVSSGDYGVVATALYDYQAIEENDITFDPGDIITNIEVIDEGWWSGTCNGQTGWFPSNYVEKLQEYMKHTRIPVDLAFGADLDEEQEEQNYSDYTSEFKDRLQQSYEAAGQTASKTRHKPQKNYNKKVKRREFCLGDRVLMLAKGFLKGRHKLADXWKGAYRVEKKHKDQPVYDIISEKDGQRCTVHRTFIRQCMFLEGNNTDTEDNNGESTESGIPERDDNRAESKMVEEADRNIRETKMKQNNVTVNKKLTDERGKEEESRPKRKRKQPGYLKDFVCQHQYVRGSTAYQDKLKKRSRTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6V1</accession>
    <name>A0A6P8H6V1_ACTTE</name>
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        <submittedName>
            <fullName evidence="12">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116288546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551211.1">
        <property type="nucleotide sequence ID" value="XM_031695351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6V1"/>
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        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="GeneID" id="116288546"/>
    <dbReference type="KEGG" id="aten:116288546"/>
    <dbReference type="InParanoid" id="A0A6P8H6V1"/>
    <dbReference type="OrthoDB" id="5972388at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551211.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35670" checksum="A18B232CDB639BD5" modified="2020-12-02" version="1">MTSRNITNPSSVLPPLIRDHFFLPRNEHEDNFLLAMIVINAVMAAVTSCSNAVVIYTISRTPSLQTPSNILILGLAISDFSLGVFVQPCLSFRLFAELEYNLRLYYWCRLIYLASAWSLSVVSILTLTMVIADRFLAIHLHLRYQELITTKRYMIILGIIWLVSLWFGAYNGMHDTDRAIRYVYIASLSLLTTLNGYFIFKIHRAIRRHSVQIQVNTLGQDMPRHKKSVKIMYFMIGAFVVCYGPYSAIMVARQIVPKRTLTVHLCLISFATLLMFNSALNPIIYFWRIEEMRNAALVLLQKTRRCGNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7F3</accession>
    <name>A0A6P8H7F3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein F54H12.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116286328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548662.1">
        <property type="nucleotide sequence ID" value="XM_031692802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286328"/>
    <dbReference type="KEGG" id="aten:116286328"/>
    <dbReference type="InParanoid" id="A0A6P8H7F3"/>
    <dbReference type="OrthoDB" id="5955637at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031548662.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49079" checksum="5E971A331A1AE829" modified="2020-12-02" version="1">MAHPTRSQHCSKSELDLFLAPSVQTNIERGQWIEYFSVSNITDSGPIEFNVSGSGDEFTDLRQTWVYNKVMITKANGADLADDDKVGPVNLFQQAMFSQVDLTINDKMISTSTNTNPYRAMITTLMTYGSDAKTSQLGAELFVKDTPGKMDAVDPLALAANRNYGLHTRYKHIKGSSPFELMGPLHLDLFCQDRLLLNGVTLRIRLNRSKNSFCLVSSEADANYKLVILQSTLYIRKVKIYDDPFLGIAXALEQAPALYAIRRVECKAMSISTGQMSFSPDDVFLGSIPKRIILGLVENTAFNGSFNRNPFNFQHFKATQVGVYVNGESYPMKALQLNFDQNLYLPGYMSLFSGTGSLFHNQGNQISREDYPNGYTLLAFDLSPDLSAGPHISPIKQGNLRIGIQFAEPLPVTVNCIIYAEFDSLIEIDENRNVTFNWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H907</accession>
    <name>A0A6P8H907_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Regulating synaptic membrane exocytosis protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116286514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031548910.1">
        <property type="nucleotide sequence ID" value="XM_031693050.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H907">
        <property type="interactions" value="801"/>
    </dbReference>
    <dbReference type="GeneID" id="116286514"/>
    <dbReference type="KEGG" id="aten:116286514"/>
    <dbReference type="InParanoid" id="A0A6P8H907"/>
    <dbReference type="OrthoDB" id="420032at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04028">
        <property type="entry name" value="C2B_RIM1alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000001">
        <property type="entry name" value="Regulating synaptic membrane exocytosis 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054386">
        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22601">
        <property type="entry name" value="RIM2a_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="RabBD" evidence="7">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="828"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1625"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="931"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1386"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1532"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1754"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="492"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="931"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="965"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1541"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1759"/>
            <end position="1777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031548910.1"/>
        </source>
    </evidence>
    <sequence length="1813" mass="197027" checksum="3D85DA92EE3A73DF" modified="2020-12-02" version="1">MAGMRAPSSPPPPDLSHLTEEERNIILEVMNRQKNLEHQTIEMQKQMMKEVATYENQLEKKTDPKVKVTDPNVCEICLKTKFTEGTGRECKYCKLKCCSRCGVEVSIPGAKQTTSAPSQGFSLISNLIQDFKTLALGPEVHWLCLVCKKKQEVLTKTGSWFGPKDPNMKAIDDPASQFGSDFKAIPSEEDKRAMRRQGSARGNFRRGMENETDRARRIESERQNYLRRPSLSDEEVESIQNAPYGQYYSDDEASRYGDQRGRRKVTFHDEKMKRHPGGMQPNPMHPQGRGSKGPYFPDKGGKPGMGPPGQTPGRGGPAQGGQPGSRQGFPPQQGPGARGYHPQQGQPPGGRGYGPQQGPRPMAPGSQQGMRPHQQQGQPQGGRGYGPQQGPRPMAPGTQQGIRQGFPPGQGGPQGRGAPGQGRGGPPQQQHGMQPQQKPMDRGRGMAPGSQPAGRGGMTPGTPQMARPGSQQSPRQGYPQQGPLDQRMQMAGSQQMGGPQKMGGPQQMGSPQQLGGPQKMGGPQQMGSPQQMGGPQQLGGPQQMSGPQQMGGPQQMGSPQQMGGQRQMGGPQQGRPQQMGGQQQLQGRQPHGPQKMGTPETARRKLQYPGQGSDQQKMNQGAERRTGMVGPPPQIGNIQGHPGSEPKQVPYPGQIDGSQGQGHHPDTRIVPTQNGRPGTSPQHPEKRGARDPRHFDDGRTGYRPDSQQGYSPRGLDGQGVAHQQQDSRGYGPPPPSQDHVKGRPPYGSPTHMIGHGRDSPQNRINNIGGHGVMEDRYDSRQLGRNSDGMAGEPMMNERTATPTQDISNASESAIKWSPPDDDNKCIGEVLLTRDPRTPPSSMSEPSSAFGLRVVGGKMSDGGKLAAFVVDVVRGGPADMQAKLQKGDEVMEWNDQSLVDCTFEEVQEIINSTDDSPELHLVLCRDKNKFPRKDTRLSRDPGRRESPTRRVPTSTAGSPVKRDRTSPLSIMAGQQDSRPTFGADRTNGPTGPGRLANDQPGFGSQVGDDDFFFGGGPGPDSRTVDAAGQKGRTLNGRIQVKLSYDEDASNLNVTVVAAEGLTSKETSTPPNPYVRIYFLPDRSMQSKRRTKTAMKTANPKWNQTFVYPCRIQKFGGRALEITIWDYSKVGSSEFIGEAIINMTEANMDGSFCWYPLKTHDENGEPLAPPTPNQSPQSSFRSKGQRGPGEIGYGSDYEDDSLRYPAPNGMIPGSQGSGFGPESDRMHRASPTNTYNQQIVPAHTGPYYHMSTPTTTHGTSYPYTAADHNRTQQLQLRSIQHPGLGRPTDGRMSPGMSPVMHHGYHTLPGQYPLGRTSPVYGPGQKKTRALPQLPHGKEPMDEEERARAAKQKLKEMDIDKAKLVIGGSRGRVGYGQAPDYLYGDMPYDSSATSPRPGGHSPRMSPVSHPRHAIGPPHHMVPQQDRMYSSDIPRDVVPYDSHRALYSSRGAPRQRRNSTSMIPTIEQDGHRSPMPSASPVPLVQTGKSASITYLPAAEGGERIPNGRLPFDQNMSGSLNNLAVLSTGGFIKTSSRQVMRNENYSGSGRSSRSSSIADSDRSGSMNSLPGSIASSESGRHGLYAIMNAENTIPWVPPSLKLGNEGHLGDFIEGLGPSQMVGRQVLASPPMGDIQLALCYRKGALEVEVIRAKGLLPKPGTKMLPAPYIKVYVMEGKRCIAKKKTRTARRTLEPLYQQVLEFKVDVQGKTLQIIVWGDYGRMDRKVFMGVVQILLDDLDLSNLCMGWYKLFSTSSMCDPPLPSSSPLGGSPKKSPGPSPRSSMVHAASPRMSPLPTIMPPPGHSPRSNVYDDPDGDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA21</accession>
    <name>A0A6P8HA21_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116286893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549345.1">
        <property type="nucleotide sequence ID" value="XM_031693485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HA21"/>
    <dbReference type="FunCoup" id="A0A6P8HA21">
        <property type="interactions" value="2152"/>
    </dbReference>
    <dbReference type="GeneID" id="116286893"/>
    <dbReference type="KEGG" id="aten:116286893"/>
    <dbReference type="InParanoid" id="A0A6P8HA21"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="637"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="735"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031549345.1"/>
        </source>
    </evidence>
    <sequence length="798" mass="88695" checksum="1FF847BC7BC8226F" modified="2020-12-02" version="1">MNMSRVRFSSEVSTDEDTASHQDNYHVEVYDEAPIVRGSNLRVVQDYNDTFMEEPDILAQYDDFHTIDWVRDRQRDRTRFRRMKRLKHGTIWERIKQANDAWGGWLVVFLVGLSAGLCAGVIDIGSSWMSDLKIGVCPANFWFNKESCCWSDDTAFDGSDDDCKQWKTWGEIFTGDSNSSASLYVLNYIVYVLSSLGFACLAVVLVRWVAPYACGSGIPEIKTILSGFIIRGYLGKMTLMVKSMSMMLAVAAGLSLGKEGPLVHVACCCGNFFSYVFAKYHRNEAKKREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPMKTLWRSFFCAMIAAFTLKYMNPYGTGNLVMFYVEYDTPWKLFELLPFVFLGAVGGIIGAIFIKGNIWWCRKRKNSRFGAFSIAEVLLVAVVTAFLAFPNPYTRQSSSVLIQNLFRQCGPEDKSELCEYITNNKTINVNDPRYPGAEAGDGVVTAIWQLLLAAAFKLLITIFTFGLKVPAGLFIPSMAIGACIGRVVGIGMERLAFSNPDWLIFSSSCGKSINACVTPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTGGLSYIVPLMVAVMISKWVGDAFIKEGIYDGHIHLNGYPFLDSKEEFTHTTLAADCMRPRKNDPPLTCITQDGNTVGELEQLIEESHFRGFPVIVDQESQRLIGFVLNKDLRIGLKHARIRNEDIVSASKVYFTEHSSLYSSPGQAVHLSLRHILDVSPIQITDKTPMETVVELFRRVGLRQTLVTHNGRLLGIITKKDVLRHIATLANQDPESILFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB14</accession>
    <name>A0A6P8HB14_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PC3-like endoprotease variant A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553659.1">
        <property type="nucleotide sequence ID" value="XM_031697799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290698"/>
    <dbReference type="KEGG" id="aten:116290698"/>
    <dbReference type="InParanoid" id="A0A6P8HB14"/>
    <dbReference type="OrthoDB" id="6017542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.850:FF:000001">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF23">
        <property type="entry name" value="FURIN-LIKE PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027639987" evidence="11">
        <location>
            <begin position="25"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="12">
        <location>
            <begin position="408"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="529"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553659.1"/>
        </source>
    </evidence>
    <sequence length="805" mass="90319" checksum="6D4414B3F8074622" modified="2020-12-02" version="1">MKSRLWVHWTLVILFIFQISSLEGRKFKTRVNRNGSTRKSRYKGPKLTRKEWEQLHKFEDALKSEDGNLLFTNSWGVQLDPAELEVADRLAEKHGFENLGQVGSLKGYYHFKHVGKPGERHRRHAHAHEKTKLLMLEDEVVWAEQQHVLVRSRKHDVPHDPKFHDQWYLVSQSVHHGTRCAGEVAAAANDICGVGVAFNANIGGVRMLDGQATDILEGSSLSFQSAYIDIYSNCWGPKDDGKTFGKPGKLAQEALMQGXLRDDDCNCDGYTTSIYTISIGCIGDHGLSAYYTELCSSTLAVTFNGGSHREREENKMVTTDLHHKCTEEFKGTSSAAPLAAGMFALVLEANPNLSWRDVQHIVVETAQVTSPVDEGWMKNGAGYHFNHKFGFGRLDADAMVKKAKIWKNVPLQRICHGPSSSTQQEIPTGGTLSITIDTIACSGTDKMISKIEHVTLTVSFQHRRRGDVSIDLFSPSGTRNEMLSTRRYDESKNGLHDWTFMTVHNWGENPKGEWVMNVTDNLPMLNKGVDPNGYVQHDTSKQEADVEDLEEEVIDDEKKDDEKKTQELEAQKNGAKKKKPFDAPYPEGVKKDKVPTVTKRWFTDRNSNGTVDQTDLMMAYQGAYYVPQYQQEMLDPSLTDAMTQGLMGGNPYAAYYPYDSVDTIESNERKQATENGVDRNVINGNNDNSDDSNQVYGYDRYSYNENEPXTLKTSSLSFGKKKADPKFERQKVQITAEETGSQRVQVNNGFQEEFVPGLNPESGRVSSGVLLEWRLTFYGTGPEGSEKSEDSEDGDEDDASAVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBQ4</accession>
    <name>A0A6P8HBQ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-lysine N-methyltransferase EHMT1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553066.1">
        <property type="nucleotide sequence ID" value="XM_031697206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBQ4"/>
    <dbReference type="GeneID" id="116290201"/>
    <dbReference type="KEGG" id="aten:116290201"/>
    <dbReference type="InParanoid" id="A0A6P8HBQ4"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10543">
        <property type="entry name" value="SET_EHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF4">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="672"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="705"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="8">
        <location>
            <begin position="823"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="892"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553066.1"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115123" checksum="C2FC2BE870F4973C" modified="2020-12-02" version="1">MFTGRHFADFNPQEQYLEPIPIHSPSRHMNSSCSSEKNVNFEEAFNRKIEHLLSEKGQSDYNQLKKPSTSSSNLSLSTDYLQTSSPQPFVSVTRKEDKTTKDNSIIEMSVETSLDNDTTDEPVEFSLSVNDELILSDQSLDSSSSNASPSAADNTKNIDVQAGPSMIISINSVPSRFPKRRRSSLDEKNKPPPPKTVKIAPFNRAPSGGSLSFPHETGQPEIGAVADGGKSLICHAVPLTANMISKTRKPPGTEMVSIGKADAFVACIPMSCEGKFTPSQCTIPKQNKCSCKAHIKKQVQGMNKNDPLVIDSDDDDDEEEVTIVNEVRPPSTTNTPTKVISSIDIKTPTTSHSTDIDVTTTNMTTAPNKETPTHTDSQPSALQKEPMATPLSPRHRARLSADFKSHQKPAPQISSQAIRTLDLSTSTQTSIVATKFNDRLKAIERAASSSATSATSAVSESSPSPSSSPSSKPVEEHDVVSSPDNLLKMLQEIKRERPYKKLRVTARNLHQAVKNNNLSKVLALLVEGCKPNVQVETEKGRTAVHAAAAGGFLDIITCLKMSGGDLDVLDYDMRTPLFDAVENNRIKTVIYLIDAGASLRVKDQGGMTLLHVAARRGHDEIIRILLDSKKFNINQKDDGGWTAIMWAAEDKMVETAKLLLHRGGNVHLRDLELNIPLHWAAFAGSYQMSLVLLENRSDLHAINRHGETPIHIAARENNYSCVQLFLNRGARIDITNNEGSTPLQVALPETKSRQLIETKKLLLQCQPQPQYRLLSCDISRGQENVAIPCVNEVDDEPFPEFSFVKECCEVGGAGIEWNINTIQACICEGDCGNNPNCSCGKMCDEEVIWYDKEGLLCPEIHKLDRPLVFECNKMCKCWSYCRNRVVQKGMQYPLQLFKTKKKGWGVRALCAIPKGTFLCEYTGELISDAEADTRESDAYLFDLDCKESEHELYCIDGGRYGNISRFINHSCEPNTIPTRAFVDHQDIRFPRIAFFSSKDIDMYEEVCFNYGDRFWEVKKEEFFCQCGTPSCNYKAPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HD60</accession>
    <name>A0A6P8HD60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC116290649</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116290649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553596.1">
        <property type="nucleotide sequence ID" value="XM_031697736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HD60"/>
    <dbReference type="FunCoup" id="A0A6P8HD60">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="GeneID" id="116290649"/>
    <dbReference type="KEGG" id="aten:116290649"/>
    <dbReference type="InParanoid" id="A0A6P8HD60"/>
    <dbReference type="OrthoDB" id="5985081at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031553596.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39090" checksum="7583F27CA0350ADA" modified="2020-12-02" version="1">MNSTDETFVEQQKIQSYKRVLAITSACCLSILSIVTTTSNILLLIAIWKDPLKCFKSVAKCFIVGLSMADLITGVTTEPFFTSYYFIRFVQDVDIKGIPLVLYEIGGIISGVALKYSFLVVLALSWSQFTAISWPHKYRRFVTNRNIVIFMILAFLYLVFFTAVQFIGILDPYTFHKIDLVCNSSFLSINLLIVSLLLYRAYRRRAHLHKEFSAKPLTSENETRSKRRKQVERTLDQQFTIVSIYLGAILLLCALPHVLAVYVYLYFAKDLTIQSQLNLLVVLRISDVLLFVKVCADPFIYAWRLPKYRKTLLTLFRIHEQKKNEEETLVGIPLTERMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEX7</accession>
    <name>A0A6P8HEX7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAP kinase-activated protein kinase 5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116288462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551115.1">
        <property type="nucleotide sequence ID" value="XM_031695255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEX7"/>
    <dbReference type="FunCoup" id="A0A6P8HEX7">
        <property type="interactions" value="2744"/>
    </dbReference>
    <dbReference type="GeneID" id="116288462"/>
    <dbReference type="KEGG" id="aten:116288462"/>
    <dbReference type="InParanoid" id="A0A6P8HEX7"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551115.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57961" checksum="21F557AE77D73388" modified="2020-12-02" version="1">MAEEQKERRELVMKITPLEDDYEVNWTKKLGSGISGPVRECTSKRTGVKYALKCLMDNPKSKSEARCHYMCSGHSNIVTAIDVYANKIVLPGEMKPSPRILMVLELMEGGELFEQIRTRRKFTEKEAMILTSEITQALYHCHSFNVAHRDLKPENLLLVSRDEEMVVKLADFGFAKVDQGDLVTPQFTPYYVSPQVLEAQRIHRAQKSGRFPFLAKPYTYDKSCDMWSLGVVIYIMLCGYPPFYSEVPRKQLSQGMRRRIMAGQFTFPDPEWSKISNEAKDVVSKLLCVEPGQRLSVVELLEHPWLQHQDKNDEDVILETPARITADEEAFEEAMTAHNVRLTEMRISDRVVSLKSISKAHNPILERRKHIAKHRMDEEAPSIVPSQVDNVNQDAIKSLRDVIAFCIMPPKNNTEEYCAEEELSKLVKKALEHNSTSQELKDALSQESWQDDKFLDSVDKRRLAKAVRSIVHSMRAYSTIIFVVVIIVIIIIISVIACIRGSRKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEY2</accession>
    <name>A0A6P8HEY2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase TRIM33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116288466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031551120.1">
        <property type="nucleotide sequence ID" value="XM_031695260.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116288466"/>
    <dbReference type="InParanoid" id="A0A6P8HEY2"/>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="10">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551120.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="51225" checksum="94C4B8BDF6CA29E5" modified="2020-12-02" version="1">MESFVSELAQEVRCSLCKDRFIEPKLLGCFHAFCIACIKRHAQLQSDEEGNNRGNIFNCPECSSETSLPELSDVKDLNPSPLHTRILKVLEFVESDKVCSISNSHSTASWYCFECSRSLCDECQMNHSLFTKDNHKVVSLSNLKKEDXEFMLAKEDNCYHHSDCKLDFFCQSCDILICFECLKLDHADHKTILNEKHATTVKDSLDDQLKKLSIQEQQMSSDVKVLEYFAVNTKEKGEMAIKEIQAKAKEIIEKVQESERELIKQIQEQIDNSEKEKRKGWNVLNKTERAKRFLNQAIEKRLPTSHMKNAQDLLCPMTDDVVPSVQENSEVVFVPSEECIGLLKVGLGKLTREESYSYANKDDNGGVEDDFTLIDGIICEKKERYSRKRGKERIRKKKRETKRENQKTENEEKTKQVERTPTALLLNFSNSHCFPCNEQLITGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFS4</accession>
    <name>A0A6P8HFS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Paired box protein Pax-3-B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116291618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554661.1">
        <property type="nucleotide sequence ID" value="XM_031698801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291618"/>
    <dbReference type="KEGG" id="aten:116291618"/>
    <dbReference type="InParanoid" id="A0A6P8HFS4"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF49">
        <property type="entry name" value="PAIRED BOX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="227"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031554661.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41171" checksum="EA3099A6B087C7E2" modified="2020-12-02" version="1">MSYLEGEVDLMDKSPWDGCCCVVEAVGITDGGEGKVNQLGGVFVNGKPLPRIVRQQIIQMAELGVRPCDISRQLRVSHGCISKLLAKYQETGSFEPGKRRTARTNDVTEDHEKGHYRMSWEDQILNGSKQPSLNSTERYFAGSHEDFWEKYGFXRYEGSNDKEVKREXTNSLSRTRCSFSIASILDLDQTERSQSSSHGSFHSKFPGDGGEYGHFTQNNLPKKPLIHYXRRNRTKFSKKQLEELERTYDETHYPDITTREALAKLLKVPESRIQVWFSNRRSKGKRKMRSQMELNSELSSTKTYSYERDESVSRHSGCHHRAAVVSPVIRYTSSFSPASPCYSHYMYFDQDSHIYSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI22</accession>
    <name>A0A6P8HI22_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Uncharacterized protein LOC116289453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC116289453</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552260.1">
        <property type="nucleotide sequence ID" value="XM_031696400.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_031696408.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552272.1">
        <property type="nucleotide sequence ID" value="XM_031696412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HI22"/>
    <dbReference type="GeneID" id="116289453"/>
    <dbReference type="KEGG" id="aten:116289453"/>
    <dbReference type="OrthoDB" id="57679at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552272.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56630" checksum="2212E7B0E9DEF9F2" modified="2020-12-02" version="1">MGGVESSQLADVPPGFEYMCIVINKPDGVRVLHGGDRELVIIKEAIEESWKLGFDANQKTKCHGYVKSFKLSGTPFEKGTPQQFALEARKMFSQILWKLNNAGWKLLITTDLSRKMAFGTFFFVKQGTISISYPFPCINISSSDKLQFINFFQNLYPSIKGVIEENWSPGIQFVYTEDEHMLDVQLFGDPWKGMGTETVEARSLIQKLVEFAAKNQLALCCSANIKNTADSLFFKHEPRFESGIVSPFVTISLNRDNRLRLINAKPELVPVVRKVIEDAWGWRKGIRKEGDYCGSFEFELHGSPWWSSDKESIMARHMIAKLLEAMQCHGWHAVGAFDVSRRTTNKSVFIFQQSAPLSTPIMCLSPSSTDKLRLINAPADVIQVCRDIITKRWPKGIQKEKEKLTEPGVSCLQFTLNGTPWDGENDDKYYVRSMLCFILQALTQKNWKVIVSGDVSAKYKEDDDDVKFPTDVHSWWLMQLDPSATLLGAPPSYDSIMGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIE0</accession>
    <name>A0A6P8HIE0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 39B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556159.1">
        <property type="nucleotide sequence ID" value="XM_031700299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIE0"/>
    <dbReference type="FunCoup" id="A0A6P8HIE0">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="GeneID" id="116292949"/>
    <dbReference type="KEGG" id="aten:116292949"/>
    <dbReference type="InParanoid" id="A0A6P8HIE0"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556159.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="79574" checksum="3BEE4B509D3208C7" modified="2020-12-02" version="1">MTEQGKGELDSVASCSSKSDEKALPDAIRTTAVAINLCLSNKFYKAQRMLEPLAKESMYHALGYGTIMYLQAVMTFEPQAIEQACESIKVAMDVCDKQRYKQSWSESLSSWIWNPSYEGITEEERHAELCYAECLLQRALLTFIQDENLISFIKGALKIKACYNSYKTCFNMVMNEPEGLQKSPQRKDFEGGVHLGIGSFNLLLSLLPTRILKILEYIGFSGDKFSGLEHLDKGCKGDSLRSPMCAMILLAYHSVITYYLGIGDGDVEYADEILQPFLKTFPKGAIFLYFAGRIKQVQGRLDEAEERYNYSIKVQSEWKQFHHICYWELMWCYSLQQNWPKAFHYASNLLKESRWSKTTYMYLKGSFRLMARITGQQIAKEDDNGKEDTEEYMFRHLPNYKQRIAGKSIPFEKYSIHKSVKYFSQGNWLFLPGLELIYMWNGFQVLRRRPDLSRHLLNLVITEQQKLDQDKEREYYMDDWCLGKILEGMCYLCMGETEKGRRCLIAAVEKSQDLVLDKQLGAYACAEIGFLYMDQGNYVQAKKYLKSASHDYQGYFLESRLHFRIHSALHKIKIIEKEHKLAMKKVKKNNNTVENSVSDDSEASEDGSNYSTASEGGKSDMVFDGTVEDFVDAQTDDTRASCSLNTDADGPSQGVANKNGKSGTNSLGTGSSKPIVSQNPSSQNNNQQVPNLLLETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJB4</accession>
    <name>A0A6P8HJB4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">La-related protein 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116291868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554953.1">
        <property type="nucleotide sequence ID" value="XM_031699093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJB4"/>
    <dbReference type="FunCoup" id="A0A6P8HJB4">
        <property type="interactions" value="2389"/>
    </dbReference>
    <dbReference type="GeneID" id="116291868"/>
    <dbReference type="KEGG" id="aten:116291868"/>
    <dbReference type="InParanoid" id="A0A6P8HJB4"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000131">
        <property type="entry name" value="la-related protein 1B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="309"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="651"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="951"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554953.1"/>
        </source>
    </evidence>
    <sequence length="1206" mass="136996" checksum="424D5445649D529C" modified="2020-12-02" version="1">MTEVESVSKPNTDFTKEESSVSEPQDVVLNSTNKENHQETEKNGQETGEDRTLTKEKPQKGKNIALAPPPPTNPWTRHLKQAEEKAEPEKPVVTKASTTTKRKAKGSEFNDITNWPTPGELATSGPKEPKPPVIKKENIENEQKPDEEVVVKSDKGTPKKKGNSGPRPKWVPLSLDGSEYSGEGQSTNGTGGKKSPDDGPPNKGYKSPNNRFGSTTSSTESRSSTRGGRGGRGGTRGRGRGGRQRSPRDHQRPFQYNQGYQYGSGSYQFFDGTTYFQSQQNQNSGQTPYGMTYYYNTQDTQSQTYAPSAVNEITLLEFIRKQIEYYFSEENLRKDFFLRKQMDDDGFIPIALIASFYRVQALTQDPNQIQEAMKDSEVVETVEGKMRKKENPSVWPLPPNSPLTVKNASTYIVQPSYTTEFYDQTMNFQNIPNQEVVDVSMEFENDFEETSIPQAEETVTKEEGVAEQKVEQAQETPQVVSSEPEPKKPVKKSKEDEWKEVKRKKPSTPKQTSEFDSNDQEELDFKFDEELETQGLKPSLSSTYWDDDSDDDLDDQDIHKIMILTQTPPPKKHDRTGDFVPRSKLTHELSAVINDGLFYYEQDLWDDGDFCYLNRKIELTSSWKRVDIISQDQFNSKKDALEAARPRSLTEIDKAGKTSNIHTVPHVSLSPNAEVFRPRSNTLPTEPLSRSLPTSVPESPSHLQHTRRQGSRTPKRKDAKAAPRFFPAFSKEKLNQGPHKRKTKYSPNPPVESHVGWVMGTKDYPPRSTSVSESSDVPPGSTALVGSFGSTPQSIPHFEHPSHRLLKDSGFQQQIYSKFHQKCLKERKKLGIGQSQELNTLFRFWSFFLRNNFNKKMYEEFKQLALEDAAAGYRYGLECLFRFYSYGLEKKFRPEVFKDFQTETMRDHDQGNLYGLEKFWAFLKYYKGNQKFDINPDLQKRLDKYKTIEDFRNDPHNQFPVDPYHHHHKPKKDHHKDAKDHHPGDDTSKEPHGHDQEDHKSGKGHHKPGRGHQKDHHPSGDSKHDHKDHHPSGDSSHDHKEQHTDHHPSGDSSHDHKDHHPSGDSSHDHKEHHASGDSSQDHKDHHKEHHKNPKPKREHHKDGKPLHASHESSHGHKDKTSHKDQSKPSEGATKKDAVKGKTQHEKSSGDGAKAKASDKAKHPKEPSPSKEKDTSAKPKSNPKDSSKTGQAKDSSTNEAKEGKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJI0</accession>
    <name>A0A6P8HJI0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116292781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555996.1">
        <property type="nucleotide sequence ID" value="XM_031700136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJI0"/>
    <dbReference type="GeneID" id="116292781"/>
    <dbReference type="KEGG" id="aten:116292781"/>
    <dbReference type="InParanoid" id="A0A6P8HJI0"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031555996.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40067" checksum="735EC6C306BAF5F9" modified="2020-12-02" version="1">MYSPPYVFYNTNGRVKDNQGTNGIIVDCLLFSFKMCYHSCPSPLNITWKVVNTSNELEQEITSGQSDIILPITSRLVNSLSWPDYTGTPLSFNPIVKTSSRALIINKNHFNQKSMELMLQALLDTWPIFVYTFILAGLSGVCIWILESRGNSDEFQRTFLKGWWEGFWWAFVSMTTVGYGDKTPKSIFGRVFGVIWILVGIVIVAMFTATVTNALTLINSGIENKKVAVLSSTGASIDAINKGTQPIEYGSFQEMYEALESQQVEGIYIDQYVGAHYMKEISDEDLRVLTIVDTEINYLLAVNANTYKEITKNVCVLEALGHTSCDRLLQKYLLPIKSFSFNEDYKGLLSSSSEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJY5</accession>
    <name>A0A6P8HJY5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14 15" type="primary">LOC116290147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553002.1">
        <property type="nucleotide sequence ID" value="XM_031697142.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553003.1">
        <property type="nucleotide sequence ID" value="XM_031697143.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553004.1">
        <property type="nucleotide sequence ID" value="XM_031697144.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553005.1">
        <property type="nucleotide sequence ID" value="XM_031697145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553006.1">
        <property type="nucleotide sequence ID" value="XM_031697146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJY5"/>
    <dbReference type="GeneID" id="116290147"/>
    <dbReference type="KEGG" id="aten:116290147"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13113">
        <property type="entry name" value="Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF81">
        <property type="entry name" value="WNT INHIBITOR OF DORSAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653058" description="Protein Wnt" evidence="9">
        <location>
            <begin position="23"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031553004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031553006.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38113" checksum="679CBA2DD5AD20FA" modified="2020-12-02" version="1">MKLLIQCVLTCCIVLVLHQGQCVKKQDIFKIFHRGREAYDKLLTSVRNGANMGLQECRSQFRYRKWNCTLNIETNVKIKLPNWTNIPATRETAFAHSITTAGVTYSLTRDCRMGKFEDCSCVHNKDSAAKGNWWGGCNENIKFGEVMAKHFLEAIDKGNGARTLLILHNNEVGRKAVRTTLKKQCRCHGMTGSCTTVTCWRKLAVFEEVGNYLKKKYTQAKRVSIIRNKLKRKGSNGFKTISKKDTNLLYTESSPDYCQRNMTFGAVGMIGRVCEGTKKNLDQCRKICSSCGLTSTNFIEKKRVICHCKFEWCCKVKCETCRRSEVKTKCTRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL33</accession>
    <name>A0A6P8HL33_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZP domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553320.1">
        <property type="nucleotide sequence ID" value="XM_031697460.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HL33">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="GeneID" id="116290430"/>
    <dbReference type="KEGG" id="aten:116290430"/>
    <dbReference type="InParanoid" id="A0A6P8HL33"/>
    <dbReference type="OrthoDB" id="5977047at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028204740" evidence="5">
        <location>
            <begin position="26"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="6">
        <location>
            <begin position="84"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553320.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="49868" checksum="410206E39745282C" modified="2020-12-02" version="1">MGSSGRTAIVSIVLAIMMKSGLVNATTVLPSSPSPTTTMNTSPSSPSPTNSVTYSSNNTMGISPTRTSVVTATNSVLPMLPTVTCQENHMEIELDKNTYSNLNSSAFHLRDSSCLGVVTGNIIILSTPLNSCNTISKQTDDTVTYQNEVKAELAIKINPNDTVTRHDALVLPFNCTYKRRKYVSVSFKPKRRVDAEEGAFGNFTFLMDLYSDNSYTHSYNISDYPISXSGAFGNFTFLMDLYSDNSYTHSYNISDYPISVQLNQRLYIKYQVLSDKADLHVCNVDKTINYNYEPNREQNFSIQAFRFIANHPVVYLHCLLLVCHTTYNTSKCAVGCQNNRVRRDMSRDAQESNLYHLSSGPITLKKAIKSTSDKSTSPGVTVVALSSAVGVLLIGCIVLLMVLLRRRKRKSYKTECDIEPTQLDAYDNPGVNREDDPAGLKMSNQQDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM24</accession>
    <name>A0A6P8HM24_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116292828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556043.1">
        <property type="nucleotide sequence ID" value="XM_031700183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292828"/>
    <dbReference type="KEGG" id="aten:116292828"/>
    <dbReference type="InParanoid" id="A0A6P8HM24"/>
    <dbReference type="OrthoDB" id="5986166at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556043.1"/>
        </source>
    </evidence>
    <sequence length="987" mass="112972" checksum="DD04A3B45786C9AE" modified="2020-12-02" version="1">METLAKLDKFIEGKLKLLAFTSEETARIVQEGDVKAMDRQAKALERSIDKIHEIKLQIQEIKIEGDWEPNEVRKWSEELEAKLSKYEKEFKTIKNXVTEVESKEKEKIEQEXRQRVFEDELKLQEVKLQRQFEMEKQYKEVTDSSSKPGSFSRAKLPKLVITPXQGTHLDWMRFXSQFETEIDKSEVSQVTKFSYLKELIIPKVRGLIDGLPYTTEGYERAKSVLKSKYGKPSEVSNAHMQCIISLPVIPGNGPSKIHEFYENLVAHVQVLETMGKLKEINGYVRLTLDKLPGIRADLVRLDDNWQEWGFPQLVESLHKWCERNPITLDRKAPIPTPEHGLRKSPQKRERVFQTKEETSKIITCVYCESGQHKSVDCDQVKGVQERKKSLAAKKLCFNCTGAKHRAADCRSKHKCQRCEGKHHTSICDKQPGSNMMIAAGEVSVTYPVVVVLVDGIKCRALLDTGAGSSYASAALLERLNKRPLRSEYKRIDMMMHSTTQRIDVYNVKVQSIDGRFEMSTLVSKVDKGALLMLPNPRYAEIIKSYSHLKGVIMEDDDTKSELPVHLILGASEYSRIKTEEKPRLGRSGEPVAERTALGWTIMSPGKEMALGNMLFARXSLADYEQLCNIDVLGLEDRPEGDQSLVYEEFKEQLSRNQEGWYETGLLWKQNHDTLPSNEKGSIKRLQNLLKKLQKNPDXMEKYDDVIQDQLRQGIVEAVPETPAAKEFYIPHKPVVRETAETTKVRVVYDASAKETESSPSLNECLETXPPLQNLLWNVLVRSRFKPVALAGDIKQAFLQVRIRHEDRDVLRFHWIKDGNPDAVTVLRFTRAMFGLVQSPFLLAGTLQRHLXSLEDKYPREVQEIKRSLYVDDIITGGETSHEVTELKETTKSIFGEAGFELHKWHSNDPMLEEEDGHQKGESQSFAKQQLGVKPGETKVLGLTWNKEKDTIAVTFPERPQDTTKREMLRFLASIYDPLARSTTPWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM34</accession>
    <name>A0A6P8HM34_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116290747 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553707.1">
        <property type="nucleotide sequence ID" value="XM_031697847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290747"/>
    <dbReference type="KEGG" id="aten:116290747"/>
    <dbReference type="InParanoid" id="A0A6P8HM34"/>
    <dbReference type="OrthoDB" id="5976446at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="730"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553707.1"/>
        </source>
    </evidence>
    <sequence length="798" mass="91631" checksum="9165CEB634365C34" modified="2020-12-02" version="1">MNDKLGLPFNENGWTYVIAKEIPKQDNGTDCGVFVCQYAAHIVQGLQIFDFKQEDIPNLRLQMSDELKTLTPVSLISEWAETYGDGGSETYNDTEIYHSTDDDDDDAQKTDYSTCATDDIDKVGETLDESEKCMRNASSLQDPVGNQDTDGWDVSDAADHDRNLDFDTTKVADEXDDVNPQVYTDGTVGSYNSCGNYGKVQQAGAGSNTEGAAEGGASGKHVDDNEKEPFYVGKKIHSEQELEELISTYEKSHFCSLWKYDSKTLEAAQKKTPKKIAYAKHSLXYDYVFMKCIFGDKPKRSSQTRKRNTKSFRQGCPFEIFIKLSPGCQTLEVSRFKEEHNHELIQDVFDHLPKQRSVSTAHKKEIEEAIQLKANPKLLREKVEKTTGKKVTLKDISNLKQRTKSELKQNNLDSVIELLKNQEGSSVEVIIDEAEKNFKGLLYMDRYMKNMYTMFPELLLVDATYKLLDLRMPVYLLLCVDGNGFSEIVXMFFLAEETKDVIEAAVNAFKKFCPAWINTHVVMSDKDFTEREAFTKCFPQASLNICLFHTLRSFSRCEKMGITSDERNRSLEILTKMAYSRTRSEYAKYHQELDSISKSVRIYIDKNWTPIKAQWVSCFKDCTLNIGETTNNRLESTFSKIKSVCSKYASILQFTHEFLSVLNVLRSERSHHYVMSIVRKPIKSKCHQDLQQYLNFLTPYAAFKYVEEQFNLSSKMQPVTNDTLQKTFSFSSSRSFNNNDNFTTTSSSCTCPFQNKMALPCKHIFKVRNILNLSSFEPRTVHQRWTMTYYRTLRETRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMP7</accession>
    <name>A0A6P8HMP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553920.1">
        <property type="nucleotide sequence ID" value="XM_031698060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMP7"/>
    <dbReference type="FunCoup" id="A0A6P8HMP7">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="GeneID" id="116290937"/>
    <dbReference type="KEGG" id="aten:116290937"/>
    <dbReference type="InParanoid" id="A0A6P8HMP7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000353">
        <property type="entry name" value="WW domain-containing oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004846">
        <property type="entry name" value="PRK06197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031553920.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="34965" checksum="DF61EF7E7E441528" modified="2020-12-02" version="1">MASIPVAVAVGVGGALGLYFARQYFKGGEFKSTRRLDGKTVIITGANTGIGKETAIDLAKRGARVIIACRSPDRGKQALKEIQEQSNSQQVYLEKLDLASLKSVREFAEKIKKNEPRLDILINNAGVMMCPYMTTEDGFELQIGVNHLGHFLLTNLLLDLLKKSAPSRVINLSSLGHTMTSRFKFQNMNNEKTYGKVEAYAQSKLANILFTKELARRLEGTGVTTYAVHPGTVETELDRHTFFSSSILGAPFRPIRWLTCKTPIQGAQTSLYCAVSEDLEGVTGRYYADCAETPSSEASKNEEDAKTLWDVSVELVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN87</accession>
    <name>A0A6P8HN87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Forkhead box protein N4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557156.1">
        <property type="nucleotide sequence ID" value="XM_031701296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HN87"/>
    <dbReference type="GeneID" id="116293816"/>
    <dbReference type="KEGG" id="aten:116293816"/>
    <dbReference type="InParanoid" id="A0A6P8HN87"/>
    <dbReference type="OrthoDB" id="10070006at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20030">
        <property type="entry name" value="FH_FOXN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049624">
        <property type="entry name" value="FOXN1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46721:SF3">
        <property type="entry name" value="FORKHEAD BOX N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46721">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="167"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="167"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557156.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46187" checksum="77253485E11D8AC8" modified="2020-12-02" version="1">MYSTYQTSYFDVPDSLSLQEMMECDIREMDLNFNDPLFQEQNLFTSPDTQRVMKQERRGDCISPGDLTNLQWLQNVSIPMEKNPNSHDKQVMVDPNTVMPVQWQNPQQTNAIAVTSIPNMNTTTYPLSQQTHQNVGLTRVTESKQRSQDCKVSSKENTKPNEKAYPKPLFSYSCLIAMALQNSDAGTLPVSEIYKFMMGKFPYFKTAPDGWKNSVRHNLSLNKAFCKLERPQGASQRKGCLWSLRPERKEQMEKEIKKWKKKHAEAIRASMANPEELQLSHEDLEEVLTTPQQNIDDVAAADAAKELFGNNLIQEIQQHEELDWDDIISSGSNLNLDPALTNSMTSTINGLNLQAPPITTTTVELENSAHYFLNGDVRHDFDNTNYTTNYYTPQPQQMTHLGTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPA2</accession>
    <name>A0A6P8HPA2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="15">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116293579</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="15"/>
    <dbReference type="RefSeq" id="XP_031556883.1">
        <property type="nucleotide sequence ID" value="XM_031701023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPA2"/>
    <dbReference type="FunCoup" id="A0A6P8HPA2">
        <property type="interactions" value="2151"/>
    </dbReference>
    <dbReference type="GeneID" id="116293579"/>
    <dbReference type="KEGG" id="aten:116293579"/>
    <dbReference type="InParanoid" id="A0A6P8HPA2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05034">
        <property type="entry name" value="PTKc_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09933">
        <property type="entry name" value="SH2_Src_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000553">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000208">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000036">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000044">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="17">
        <location>
            <begin position="144"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="261"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031556883.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59179" checksum="8DF440B08FC1D36E" modified="2020-12-02" version="1">MGCCCGKPRAKYETKREPDQQKPGGQVVDGGGGYNPSIIGGYNQGPNTANRTNGMHFQSSSGIMQPSSFPGMMQQQKATNIYVALYDYDARTNEDLSFRKGERLQVVDNTDGDWWLARSLTTQREGYIPSNYVAQEQSIKSQDWFFGKIKRVDAEKKLLAPGNPKGTFLIRDSETQPGNYSLSVRDGDNVKHYRIRKLDSGGYYITTRAPFSTLIELVEHYITDADGLCCMLSQPCPGEKPITSGLSHNTKDAWEIPRESLRLERKLGQGQFGEVWSGVWNNTTPVAIKTLRVGTMSPQAFLTEAQIMKKLRHANLIQLYAVCTQEEPIYIVTELMKHGSLLDYLVKGEGQHLQLPALIDMAAQIAAGMAYLEKMNYIHRDLAARNILVGDGNVCKVADFGLARLIEDDEYNPHQGAKFPIKWTAPEAALYNRFTIKSDVWSFGVLLTELVTYGRIPYPGMTNAEVLAQVERGYRMPKPPNATDPLYEIMISCWNKNELDRPTFEYLQSVLEDYLVATEPSYRDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPK9</accession>
    <name>A0A6P8HPK9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein 63, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116291531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554577.1">
        <property type="nucleotide sequence ID" value="XM_031698717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPK9"/>
    <dbReference type="FunCoup" id="A0A6P8HPK9">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="GeneID" id="116291531"/>
    <dbReference type="KEGG" id="aten:116291531"/>
    <dbReference type="InParanoid" id="A0A6P8HPK9"/>
    <dbReference type="OrthoDB" id="5951490at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14520:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14520">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554577.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="17076" checksum="D1A811253DD19BD6" modified="2020-12-02" version="1">MGKPANDYRRRRGIYPGPLGLERHLENFIIWKSIKKMWLTRILLGRRSAPGRIFAGKNRIIKKITSMQRRNTRDKEEIIGRVESLLSTPYLTMEEEYGHTSARKKEDRQEFLLNRKRTLGPNIYAVPSKSLTDKSKAILSHLNVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPP9</accession>
    <name>A0A6P8HPP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293728</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557053.1">
        <property type="nucleotide sequence ID" value="XM_031701193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPP9"/>
    <dbReference type="GeneID" id="116293728"/>
    <dbReference type="KEGG" id="aten:116293728"/>
    <dbReference type="InParanoid" id="A0A6P8HPP9"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557053.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24277" checksum="2054F97C0C9E93B5" modified="2020-12-02" version="1">MVLKNPIFQTANIYFFNLVFCRDNYFSLTLLLFRVGNQKLREYFKTQWPLVYQGVRPGTVPPPWNDTPQDAAEMKNRERRLTFNGIDEETKFNSGNTNHWDFSLLTSVLQYSSLKFVLPSSPESKALDDLKKIRNELIGHATDAAIPNALFHTAWTDACNALALFNASKADFKCVQDDVKKPLDVLYPMLKQCVKQEKEVKDSVDTSELTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPR4</accession>
    <name>A0A6P8HPR4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="5 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116294833</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:31240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="5 14"/>
    <dbReference type="RefSeq" id="XP_031558364.1">
        <property type="nucleotide sequence ID" value="XM_031702504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPR4"/>
    <dbReference type="FunCoup" id="A0A6P8HPR4">
        <property type="interactions" value="1636"/>
    </dbReference>
    <dbReference type="GeneID" id="116294833"/>
    <dbReference type="KEGG" id="aten:116294833"/>
    <dbReference type="InParanoid" id="A0A6P8HPR4"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000008">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031558364.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35932" checksum="EF5114B706258022" modified="2020-12-02" version="1">MADLYSNKNFPPLKNDAVLRAARGEPVERVPVWVMRQAGRYLPEFREVKEKNNADFFKMVQTPEICCELTLQPIKKFDFDAAIIFSDILVIPQVVGMTVEMLPGKGPHFPEPLVEPNDLKKLKENINIEQDLSYVFKAITLTRHKLEGKVPLFGFTGAPWTLMSYMIEGGGSTNFTKARRWLYEHMEASSTLLQKLTDAIVEYLVLQVKAGAQILQVFESHAGILGYDTFMLYSFPYLKQIAERVKEKLGPDAVPMTVFARGGHYAVKELSNCGYDVISLDWTMSPEDARILAPTTTLQGNMDPAALYASHVSESTDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPR5</accession>
    <name>A0A6P8HPR5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293754</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557073.1">
        <property type="nucleotide sequence ID" value="XM_031701213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPR5"/>
    <dbReference type="GeneID" id="116293754"/>
    <dbReference type="KEGG" id="aten:116293754"/>
    <dbReference type="InParanoid" id="A0A6P8HPR5"/>
    <dbReference type="OrthoDB" id="5956485at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557073.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32678" checksum="0B0C1B8D01121AE1" modified="2020-12-02" version="1">MLKAEPEQVDNEEERNEEVENEIKNHRQSYLDEEKTICLFACMCPYLTAFYLMFIAWRYISVIFYATYATECFFKAKLATLRCDDSGVFPYPTKFEVAWQMSSAVNSLISISIVAKLSPFPGFRVIWKKLVRYARFWSLSFQLIVVITYNIILILHEHLTISFVIEVGFIIDEVTVTLVVCLWNFIPAPNKDTATSSFQCCYYVTLIAYFLENLYLFVLMSSQAALDITGIHEFEHRPASLQAVSIVMNATEATFYFAIMKFFWNKMFEPDRDLFEKETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQI7</accession>
    <name>A0A6P8HQI7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031554935.1">
        <property type="nucleotide sequence ID" value="XM_031699075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291858"/>
    <dbReference type="KEGG" id="aten:116291858"/>
    <dbReference type="InParanoid" id="A0A6P8HQI7"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="10">
        <location>
            <begin position="445"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031554935.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="84269" checksum="A65F81243B529F6B" modified="2020-12-02" version="1">MYGFIHCALADLVVGKFGEEVWREIVAKAGVELGGGSYLIHKIYDDQETLSLVAAACETLGLELNTVLEVFGAHFLEYCVQSGYDRILRVLGRNLRDFLCNLDALHDHLQSIYPGMEAPSFRCTETDDGTLLLHYYSKRPGLSYIVIGLVKAIAKQLLDTEMTCDIHQDLDENNDHVIFAIREVECKSPTASKLGLQTFDTVGRGAKKGPASDAACFTTRNPSENRGEKMSLLSFCKAFPFHVMFDRNLHVKQAGLSLMRLIKYNPKSTLVFTDIFDLARPRMDFSFEAVISHINTVFIVTTKPGVIGFPLIDDPTSETTEDAQQSILRLKGQMLYIPESDCLLFLCSPRVSNLDSFREKSLYFSDIPIHDATRDLLFLSHARRAERELVEKLEETSNNLKKIESKLIDHKKKTDDLLHSILPKAVAAKLRLNQPVPAESYKVVTILFSDIVGFTALCSNDRVVPMDIVKLLNKLYTYFDMLSGMNDVYKVETIGDAYMVVGGLPHPCENHAQKVVNMGCSMMEATDVVHSPVDKNPIKIRIGIHTGPVMAGVVGKKMPRYCLFGSTVTLANKMESGSQPGRINISIDTKNLVDQNDFTFESNXLVANPLPCFFVKRSALAARRASLVDITSSVAPNSICMFRSPIGSPTESPVPRRRAXSVEPAPTPKETDKQFPVCPMRRRTTVHKMPSRIIKENGLASMPELEYVSDGVEFNLDDSSVVETEREKLVALMGLHDKIDAIKLNNAHTQVRSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQM6</accession>
    <name>A0A6P8HQM6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116291871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COMM domain-containing protein 6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554957.1">
        <property type="nucleotide sequence ID" value="XM_031699097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQM6"/>
    <dbReference type="GeneID" id="116291871"/>
    <dbReference type="KEGG" id="aten:116291871"/>
    <dbReference type="InParanoid" id="A0A6P8HQM6"/>
    <dbReference type="OrthoDB" id="10251827at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF5">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="4">
        <location>
            <begin position="132"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554957.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22270" checksum="AB08C65116027191" modified="2020-12-02" version="1">MKMAEKILTNIPQGFNAAVEKIKIIPQDIFAEICQDVADFLQYKLSVIDTEQHQKRLNQAGIDCDAKLVSNVITYIFRSSAKAKATPNQLIEELSAAMIWEESSLAVIKHIWNEQGNFLCSPDLVKTLNVGQLVDMRWKLSIGMSSSICRNLNAPYITLLITVSDSSGNLKSKSCELTVSEFKKFSSLMREMSSMLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRC2</accession>
    <name>A0A6P8HRC2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294628 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558126.1">
        <property type="nucleotide sequence ID" value="XM_031702266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRC2"/>
    <dbReference type="GeneID" id="116294628"/>
    <dbReference type="KEGG" id="aten:116294628"/>
    <dbReference type="InParanoid" id="A0A6P8HRC2"/>
    <dbReference type="OrthoDB" id="10256523at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558126.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="59350" checksum="C86DDC62B845A893" modified="2020-12-02" version="1">MSTRKTIPKHKQHVASERSIKSSGVHSADRLFSSTPESSKTTPPDRKTGNRSTLCDWVEQKELPNTSKIQNKQMKRDIKLLQEENEELKAELTYIKSLYKQLIEELPNERFDERRVNLLKSQVIQLERQVTLQSWALNLRTDVLIEIEGQLLNVIDCLRSMQTPDVTTYSKISDLLCTVEGIRHYLSKTIEPTNPETLALPAVFMGKFLKCDKKMSSNHQTTLIDMCSGKFDHLNLRHVSKLESKLCKLYKQMVCLKEVLQEKCITSVTGSDHIGQPIRDHMNAHVQATTTLLEDSCQDLLSLSVLIPSAPWPPLNKQIRPDLNLENVMSHMPSSLSRKKEEEIRSVIDPLMKAVSYDQHMHLIEIKILKEELSFHQRMYQLQLDYTESVLSSIRTAYTEFEKSTSEMLCEPLERILEYYEALRTTTSEEDLRLFLTAFKDNAEKISDAVECLQSHRNKDSAGSIALSEYCQNFLDKLNSLIKECAIKRDTLMKKLIDLKKQESEDQLMKKQEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRD9</accession>
    <name>A0A6P8HRD9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295299 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558939.1">
        <property type="nucleotide sequence ID" value="XM_031703079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRD9"/>
    <dbReference type="GeneID" id="116295299"/>
    <dbReference type="KEGG" id="aten:116295299"/>
    <dbReference type="InParanoid" id="A0A6P8HRD9"/>
    <dbReference type="OrthoDB" id="10043502at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037646">
        <property type="entry name" value="PROSER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22045">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22045:SF6">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558939.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="79855" checksum="B58ED597A66C62D0" modified="2020-12-02" version="1">MKKSDPFEVEPLPKAFYYPSKEKELSKKEKKVCLSAPYTSKDTQHQVSSPEDLKFLKETNTLRTAQEIPTRENGSTADLSSTSQFNESWPSTERTGSLGTPLSDGTVSSPEMSQQMREWLEGQEKPVGNSTLGWYINRFRNAPPTDRQKRDQASFISKKKPNFWWLSPPSGPSTPSGQSTPVPGHTPPQKLPLSPMKPPSPTTMKRDRYTSAMSSPSSVHVDDGTTAELDRRAKELLEKSETSVETISTEPFPLPLKKPAEHKPAQHMAGLSGYKLSPQKTKIPTAERSEPISHQNPWPEDDILYQWRLARRMEKAQEKVSGLGVRVHVKKTDPYNIRRPVDVTHRASSQPFSITLPGLNTFDDVLPGPSGVSTLPGQPRPEVTPQVFSSTAVQTPSVTTTASSNMDDTIRGSHAPVSMVTSYGTSTRSIVTPVISRPCQHLESNVDEREANIYQDKLWPHMHLACDILPCQCTGDAKMHHHHHHQKHEKHKINEDRASTNGLASDVNDHVKQQNDEEKETDIPQNEIPQCKKSHFKSALSKKTTDSNREENQENKKTSSSLEDLSSSTETESERETRIPRRKGKLKQVDNKEKRKENKTSEMVQNVIGKVISEHMFSGSSSTSDNEEKRTTGLEGSGTNEKSTSDNEEKRTTGLEASGTNEKSKHPTFTLDQADSSEEEFSNDEILKILRQRSKDLKKELRRIDNLLEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRY5</accession>
    <name>A0A6P8HRY5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031557893.1">
        <property type="nucleotide sequence ID" value="XM_031702033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRY5"/>
    <dbReference type="GeneID" id="116294438"/>
    <dbReference type="KEGG" id="aten:116294438"/>
    <dbReference type="InParanoid" id="A0A6P8HRY5"/>
    <dbReference type="OrthoDB" id="10274895at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557893.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27959" checksum="3C7A643FC454FA69" modified="2020-12-02" version="1">MQNNRAKRAIQASLGKPFECFCSLLKPGVLEIDGYEIVVCECPNNICGCKWKGELNHYLLDHRKRCNFQVVQCYCGNQMYKGYFAHHLSSECKHRLVDYKLSYELDDMYVHQRCPRCCYGCKWYGTCTKYEKVHAYQCLYQDVLCYCQKPIKKWCLSEHVGTDCDLRLDLQPGMNFSDFSKPESDIEMVKHKGDQHDVILEQQRRIRELEEENRILKNSIKSFKDNVEILSFAVNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTY6</accession>
    <name>A0A6P8HTY6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116292869</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="Rhea" id="RHEA-COMP:12570"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="ChEBI" id="CHEBI:132088"/>
            <dbReference type="EC" id="2.4.1.133"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_031556082.1">
        <property type="nucleotide sequence ID" value="XM_031700222.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HTY6">
        <property type="interactions" value="1742"/>
    </dbReference>
    <dbReference type="GeneID" id="116292869"/>
    <dbReference type="KEGG" id="aten:116292869"/>
    <dbReference type="InParanoid" id="A0A6P8HTY6"/>
    <dbReference type="OrthoDB" id="6020664at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046525">
        <property type="term" value="F:xylosylprotein 4-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000062">
        <property type="entry name" value="beta-1,4-galactosyltransferase 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF30">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="19">
        <location>
            <begin position="98"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="18">
        <location>
            <begin position="188"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368121"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF02709"/>
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        <source>
            <dbReference type="Pfam" id="PF13733"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031556082.1"/>
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    <sequence length="341" mass="40406" checksum="F065B37D60D51D0E" modified="2020-12-02" version="1">MVQRGVVFAMLFYLTCAVATTIYISXLYLNDEKCDCREFMKRLVIRDGLEEHNHFLNPTKNSRQHVRDTILNNEDTGQRKPKERKDKIKTAEDESWGPHVLGIVVPYRNRFEELLEFAPHMHKFLNEKKIKHRIFIINQVDKLRFNRASLLNIGYLVARNECDYIAMHDVDLLPLNKKLFYGYPEKGPFHVSGPKLHPKYHYRTFVGGILMMTIEQFEKVNGLSNRFWGWGREDDELYQRMMEAGLTIYRHGKKHITTGYDTFKHDHDPETRKRDYKRLFNQKKESFKRDRKTGADNVEYDIMSMKKLTIDGAPLTIVNVELDCDYDETPWCKFDKPDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU69</accession>
    <name>A0A6P8HU69_ACTTE</name>
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        <submittedName>
            <fullName evidence="6">Ankyrin repeat family A protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116296121</name>
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    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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    </dbReference>
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        <property type="entry name" value="ANK"/>
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        <property type="entry name" value="Ankyrin repeat"/>
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            <begin position="112"/>
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            <begin position="145"/>
            <end position="177"/>
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            <end position="210"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="45"/>
            <end position="75"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <begin position="46"/>
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    <feature type="unsure residue" description="D or N" evidence="6">
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            <position position="210"/>
        </location>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    <sequence length="252" mass="26867" checksum="6E07FF3F0FB50182" modified="2020-12-02" version="1">MCSMSVLLGSQYLTLDIPESKYSKQIEPDQEVAAVLCSGLEAENSQAAQLKPPQTPLLTPKSEQEQTESCSTNRGSTAAQYPSLHFLAAQGEAAKIKEEIDKGANINAVDKTGLTPLAWAAAHRQKATVTLLLQNGADATICSPSGESALAFGTCQGQLDVVEQLLEYGADPNVCTLDGGSPLMFAAYNGYPQMVKVLLEHGADLTATNDEGHTAFSLAVGMGNKNVQRVIDDYLRSILENPRPQKLKTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUA7</accession>
    <name>A0A6P8HUA7_ACTTE</name>
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        <submittedName>
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        <name evidence="9" type="primary">LOC116296156</name>
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        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
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    </dbReference>
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        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="YWTD domain"/>
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    </dbReference>
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        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027671913" evidence="7">
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            <begin position="22"/>
            <end position="326"/>
        </location>
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            <begin position="65"/>
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    <feature type="repeat" description="LDL-receptor class B" evidence="6">
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            <begin position="151"/>
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        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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    </evidence>
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    <sequence length="326" mass="36322" checksum="730B44E676C38CE3" modified="2020-12-02" version="1">MLYHGIRFTAVIFCILSIAKACQQPCLFVSNTTNILSVRADLTSSTPVLHNLNRAVAVDVHVTRRLVFWSDVTDKRIKRASVDGSDVKIIVNYFIGVCDGLAVEWTTDLIYWSDTTLNNIEVARIDGTNRRTLISDNLDEPRGVAVDPLSRLIFWTDWGKEPKIERAYLNGENRRTIVSSSLGWPNDITLDHRYYKIYWVDALNDKIESSDYSGNHRTTLFHNPVVHPFGVDLLSTSLFWTDWNTVRGVHKLDVSTGAVQSNIILSGTTMGIAVFDSSRQPSSIHSCQQNNGGCSHLCLLTPIGYDCACPTGYGLGSDGRTCNTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWI7</accession>
    <name>A0A6P8HWI7_ACTTE</name>
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        <submittedName>
            <fullName evidence="12">Tachykinin-like peptides receptor 86C</fullName>
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        <name evidence="12" type="primary">LOC116293628</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <lineage>
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            <tissue evidence="12">Tentacle</tissue>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="38"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556942.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44457" checksum="D4A5E3B8713A7F52" modified="2020-12-02" version="1">MFANQSVNSSAIHFEEPRALRIFRLIIFSLVIVASLLGNAVVLKAVFELTRKSVTHYLVANLAAAEIIVSILNPFIVAYSEFMYWPFGSFLCRLISPMQTFSIVVITNTLAAIALHRYRVFSTHHTRRKLSSKEIGLVLLMIWVIALAIVFPSFLFQRLTPANPKRFPGKFWCIEIFPDGPEFPSPMMRRFYMARFLLNYVIPVIIMSASYGFVSVKLRHHRNRSIRDNEITRNTSEQENDPTTQQPNVSSQQPQQQNGAGESIEMATKAAENKNSSRSRPAYGVRDRMTRRKDFVRLERDLLKMFYIIILVFLVCYFPYQVFFLLEYFGVIHWETWKYFTVIRNYAFLIPCFSSALHPLCYGTMSKFFARALSRLVLCKNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWP5</accession>
    <name>A0A6P8HWP5_ACTTE</name>
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        <submittedName>
            <fullName evidence="8">Achaete-scute homolog 1a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557002.1">
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="term" value="P:nervous system development"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Achaete-scute family bHLH transcription factor 1"/>
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    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
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    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00010">
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="79"/>
            <end position="131"/>
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            <begin position="1"/>
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            <begin position="144"/>
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            <begin position="144"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50888"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557002.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18825" checksum="A9A233F0B866143F" modified="2020-12-02" version="1">MSSLVDKKKKXPEIDSDLGNNKGKLREKLVVLNTQDNGRKRSRVDELNCSGKNKDQRLTNSSSTRKKNCAGVAIQIEPTAVARRNERERNRVRLVNDGFFSLRQHIPYFPDKKKLSKVETLRCAVSYIKHLQKLIEEHDEKVSPFGEHENGESELNKWVVTTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX86</accession>
    <name>A0A6P8HX86_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560994.1">
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    </dbReference>
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        <property type="interactions" value="1505"/>
    </dbReference>
    <dbReference type="GeneID" id="116297000"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
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    </dbReference>
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        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031560994.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29352" checksum="5569B61CC57DD90B" modified="2020-12-02" version="1">MAELVLDPAIRLWVILPIVVITFLIGIIRHYLSILLQSKKEVDIQGVTDSQALLRSRCLRENGKFIPQEAFEMRRHFFNDEKEGYFKKTDRKGQVKNPISDPSMMVDMAKGNITNVLPMILIGGWINWHYSGFITTKVPFPLTIRFKAMLQRGIDLTNLNASWVSSVSWYFINVFGLRSMYALVLGENNAADQTRMMQDQMQMQMPPDPSKAFKAEWEALEIVEHEWALENVEQELMEEYSPSDVLALTKDKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXR2</accession>
    <name>A0A6P8HXR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116296282 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116296282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560151.1">
        <property type="nucleotide sequence ID" value="XM_031704291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXR2"/>
    <dbReference type="GeneID" id="116296282"/>
    <dbReference type="KEGG" id="aten:116296282"/>
    <dbReference type="InParanoid" id="A0A6P8HXR2"/>
    <dbReference type="OrthoDB" id="5966355at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028055982" evidence="7">
        <location>
            <begin position="21"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="319"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031560151.1"/>
        </source>
    </evidence>
    <sequence length="632" mass="69674" checksum="AA87CD6D4B678232" modified="2020-12-02" version="1">MDFLFLILVFLNSGFLFSEAVRPSFSVFVSDDFLLVGRSVKITQKTTVTEATPFRYKIKLPFNETAYMRILGLTVQTNDSLQITGNKVPNLTSSSGDENLIDEATFDLGQVTPSGSMDIVVTFVAQLLDHPKLTNGEKVWISIGAEFTNGSIWANQLAVSGFKNFDPEPVLKGSAHVPQMDQNEVVTGSTVDINFRLTHDPIKTTSIASGINITFFHPPYLVFDSMAKDPKSVHAQVISNSISTRTLSVGSFNFSEVAHFNMTFQVDPAKTKPRGQVHAAFVRIEVKYSFTSPFYPDPREMNMKKALQNTIKFYPQRDSCDVALAVADENFEASSYSTEGPPKEGKLNGPKAWVPVTALKKDRNQFIGVNFTGLKIIHRIAVQGSGDGLSTSGYVTGFRVFYSKDCAMWTLYKNKDNIKYLKGNTAANKMNVVPLDPPIEAKCIRINPTAFNKQISLRFELYGCASSNPTPAALLKSRTFLLDTATNTIYACNIPMLKKSGQASCYYSSDSGTAWTAFDHNVLNIKMINPDNKRIYGLGLRGSHFSCTAQLTIECMMISAAEYDKVKVLPGVIFAKEANKISVTDDPNSKIPVEADSFTHDGKKLGASPLGIHWYDGAWNQKTSWAFGGKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYQ1</accession>
    <name>A0A6P8HYQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116296544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560436.1">
        <property type="nucleotide sequence ID" value="XM_031704576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYQ1"/>
    <dbReference type="FunCoup" id="A0A6P8HYQ1">
        <property type="interactions" value="2156"/>
    </dbReference>
    <dbReference type="GeneID" id="116296544"/>
    <dbReference type="KEGG" id="aten:116296544"/>
    <dbReference type="InParanoid" id="A0A6P8HYQ1"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031560436.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39944" checksum="0AA7947DD256EF08" modified="2020-12-02" version="1">MNATVISSSTNRNATTPTSTKALSLCFVNDLTSVKTAKVFFYIIIFIASFIGNTLILNAVIKKATLRRSINQFIGNICLANLLITLVYMPRMMVMVVDGSHWLVEGTLGLVLCKLVPVIHHACLLVSILSLTALSIDRFFYIVVPTKQILSKKKQKFVIPLMWVVAILVRFPSLYALRLHPARHTDSLTCDDSIQKAFKSIKARRTYYTFLLIFFYALPLILIVMFYSIIIVFLKKRKRVCSNRHKADRTVDAKYKEASRKTLKMLITVTVCFVICWATYFLAQIAYRSVPCELRFWRFFLAHCNSAISPYLCMIFNKKYQEHVKNALYRSCCLCCAVCEIADEDVTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZA4</accession>
    <name>A0A6P8HZA4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116297599</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116297599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561719.1">
        <property type="nucleotide sequence ID" value="XM_031705859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZA4"/>
    <dbReference type="GeneID" id="116297599"/>
    <dbReference type="KEGG" id="aten:116297599"/>
    <dbReference type="InParanoid" id="A0A6P8HZA4"/>
    <dbReference type="OrthoDB" id="5949785at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031561719.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38212" checksum="6C4750FA8708B91A" modified="2020-12-02" version="1">MDDLNTKRNVTLCIGSHHDPHINAVETKVKLLANDLKFVLFNPLRNDHYIDISLENNKPYSCVITTGDEQVSSNRVQSVWYRWKPEKFYDGDSMYDTLTKDFALEEWKNVILSLAEFVSEAVWINPLLNIEQIKSKAFQLRLAQECGLKIPLSKITNDAASVQSLFSKPTLRVVSKPLTPLLIPPNKRIRPKEISKEYAMASFSRISVFPGIFQEMIPNGNNIRVVIVGDVIFATRSAGTKSDLGKVEQDSEPTTLPRKPCKVPEVVENGLLSFHRRAGLIYGVYNLVELDDKLFFLDCDPCGAWLCLENGLASAVSEAVAKTLIGAKTKRNKMPCLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZN1</accession>
    <name>A0A6P8HZN1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560873.1">
        <property type="nucleotide sequence ID" value="XM_031705013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZN1"/>
    <dbReference type="FunCoup" id="A0A6P8HZN1">
        <property type="interactions" value="3004"/>
    </dbReference>
    <dbReference type="GeneID" id="116296903"/>
    <dbReference type="KEGG" id="aten:116296903"/>
    <dbReference type="InParanoid" id="A0A6P8HZN1"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560873.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31146" checksum="103FB400ED5A1693" modified="2020-12-02" version="1">MPYANQPSVRITELTEENVKFIIENTDLSMANGLRRIFIAETPTLAIDWVQIENNTSVLHDEFIAHRLGLVPLTSDEVVERMNFSRDCTCEEFCVDCSVEFTLDVKCTDDQTRHVTTRDLISSDGRVIPVTSKHKEDESSEYGERDDILIVKLRKGQELKLRAFAKKGFAKEHAKWNPTAGIAFEYDPDNALRHTTYPRPEEWPKSEFSNLDNDQYQAPFDPNGKADKFYINVESSGALRPENIVLSGLSVLKKKLSDLQTQHSHEVAADVLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZZ6</accession>
    <name>A0A6P8HZZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558182.1">
        <property type="nucleotide sequence ID" value="XM_031702322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294676"/>
    <dbReference type="KEGG" id="aten:116294676"/>
    <dbReference type="InParanoid" id="A0A6P8HZZ6"/>
    <dbReference type="OrthoDB" id="10314165at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027837091" evidence="2">
        <location>
            <begin position="18"/>
            <end position="2696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1586"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1757"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1904"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2048"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2224"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2444"/>
            <end position="2467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2571"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1807"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1904"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1928"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1971"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1986"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2066"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2229"/>
            <end position="2252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558182.1"/>
        </source>
    </evidence>
    <sequence length="2696" mass="295772" checksum="6E29E62CAD587239" modified="2020-12-02" version="1">MDGARILLFFSLAIMSADQITREGLPALTNGHPGTNRGYGIMGTTDEEDSEKWAKEQDKAFKKLEKNWFQRRFSGGGSGSGAEESGSGSNSNKRKKPIQMLISRLRSSDIKLGHKRQMGYDVQSYSNTDANRIIKQAVNETIQENTTEPPPMPPTMPKTTSPVEPYTYLPPNITVPPSKVTVNEVSETTTVQGSGTASSSVNVKGVGGQEMSIKTSQKGPNGDGANNTYSANGPKPGMPVSLHVGNNLSSIDIVDMKTTPSKAINQPSSYGYYPEYSDAQVQEPHSQALITTVSGLVRTAQTQPTVTPLTPVTNNNTTSFPYSYNNQNQMETSTENSQPAETSTAGSSYQVKGYASNLSNYTSTNMNPSTAMATSEGANNENSTYNQPSVIAETTTNYYLGGVQIQNQSSTLGQQSQAQQGSLPTRSTFPWQNVTLPLAQGQNPNPSISPTQRADLTRGIQNSNSVPFEIQKTESQTPYMSVQFQTEVANPTKSQGLNIRPIHIGRLVTHDKDGGLVISSSSTYEIGRNVFDAGSSYHGSTTLNNAGSIQNTQQQPSATNTFLNTTTNISSPTNKPNSAGTWGYFNQQNQRASPTIFVTPPKDTSPTPTSWLPTYSLLKSMKTGALASQPDQATAEASINITEILFPKDDHKGLPVMVMQSPSRENNPTVKPSPIPLIDKGISQAKMNESNLGQFQFQNVGPTQGQANGSTQILTQGQTQGSMNGPTQILNKGQTQGPTNGPTQILTQGQTHGPTMGPTQKSTQSPTQGPTKVITLKLTQGPTQGPVPTSGVSTSMFSLGSNPTVVGTVNPTAGISTVTSKLPTAESSASLLAGEEKAAGNTTYLIPSIEESGTISLPGSQTDELTAKEMENMMHVEDIEDTLFGNKDSMSNELPKNEVSPGGEKEESATPQKPIQALISEVPTADPYKGVKDALLSVDIAQLKPGELLSLRLPNSQTSDIFQVKDIKSNDDVSAYSSDLDNDHEKSLDKKHILYAIIEKVKHNKDYRNAMKAIFSTGDRRSWKSSKKSGSVVRGKLKTIALPQRAILRSYSKNQLDKKNEEKFAKLVQENIGLMNVAGSHFSKEMKNPDIEFDQVHHVVEKYVKKDSNDANKLRLKLMSVGAKMHRLQRKSSIRGSKRSGLRGHRHYNKKKSSDEKGYKKTEGTFEVTLNVSGKKKKPSEEKTKEDDKSEKTANKLKPGSKLKFMGTFTDQKKENGEEDKVKKISSLRTEQTSQGLQPNRQPGNVIIEDEKGNVLYKGPVDIAALNQTVTKNGGNDTGFQLQNVGYRVDPSANSEENVVLKQGLQQVIPKKRSRGLLHRRHRLDIHNNHLRRRYSRSIEIKKDVIATKKTDGTFKLTLAVSGKTKEAANAETNKEGKDDVNINDARHQLFHDEKELTFSGTFTDGKDSKDENGNEKKKEKENGEEHEEHKKENEEEEEEQQSKEKKKAENEQKSSEKEFSNKNGQGNTTSMSQPKVNATNVIIEDGKGNILYKGPVDIAALNKTVSTKNGTYSGFHLETAGYKIEESTDPQEVELLNDGLQHAIQPSGTGTDPQELKLLNDGLQHAIQPSGTGSPLQFLEPKRKRRSLLDDTQPSKKTDGTFTLTLALKDDKKKKKENEEQRKENKEKEDQQDKERKPNEDGYYSDFPQKNDNDNYNKETASGLEKLRNVEDGKTESEKAKTVSPHVIIEDEHGKPLYQGPVDISALNKSVASKGGSLGYELQKAGYQLIKEPNQEQPVSQSETTSSQNDVVIQEASEHPNNSPNSASVYQTKQQSDNSDTNVINISSSNGDVLSGNQDDQRVSVDVTNDDGSQDHSMSAVGNEQQLLKVLQIASNIKPSDISSNKKEQEDGTKTLFNALPTLNKEIDQKPSKSKFNPLPAFNDKEYAQQQSVSDGKIKFVQDQMDKKKYREDKAKVKSSDHKIKNQEQNGSDQRKNPVTASTSFVDTTNSKLLHIYTPKPELSSKNRNLEGNSKQNDQSAPEKIPSDEMPHDEKNSQSNKSLGSAAKAQNDVELKNKENSYNVLMTDAQNGASSIGGKILQSATVIDEHKDRNQNEGLSKENPMANTIPNDGQGDVSDSSSLNKENDPNQNGQINPKNVAFLAQNIPANVQVNEAGIKTPASQMSLIGQDINNNGKHFPKKYQVLKLTRNKLKELLASSANTANVANTVNIANKEKEQQQIPVAAAMQDNPKVDNKDEFKGPNNGMEQPITLILSGPYLDQLEPRNDSASPPTNALANDQLNSGSQARQNQVNMTQTNVKNVNAWLNNPEGKNISSMLPNEMFGNDDDKILIGGGGKTVRPAAAAEGAFKSQEAASGLNVLLKTPEVQNPAFLVQSKNTSPLKISPINRLGVEAMPTISVLSGSGQRVDCHALPAGSSLTLLRCGPNGQRIVGPTVSTISKAQVASMLNLQMNDMPPQNPVPQHRLTEPDVVQNLMGAPEIRMNDEPLSNNQREPKKQEYGYGTVTDPTLYHKMSTDIRDYLDKEIDDEKNMIQNLLVGSSSPRASLPSQNNDDTDDSLPFGFAYIPGASESSLYNTEVKNQQMYQGFPNEYINTLSNVGTSRLPHKMFRSRSRHRNTRRSQIKKANRKLGPWKRRKSSRSRKKSREHPVRHWSFGGMFPPTLPLLIRPLYPQPWLLTKRCCNDNKNNRKCSKTLSSLSKIENLPTPAPASMSVWEYLGRVLCSCPCCIECYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0X9</accession>
    <name>A0A6P8I0X9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116294974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558537.1">
        <property type="nucleotide sequence ID" value="XM_031702677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0X9"/>
    <dbReference type="FunCoup" id="A0A6P8I0X9">
        <property type="interactions" value="1414"/>
    </dbReference>
    <dbReference type="GeneID" id="116294974"/>
    <dbReference type="KEGG" id="aten:116294974"/>
    <dbReference type="InParanoid" id="A0A6P8I0X9"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031558537.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="13353" checksum="C47BBBA04511EB8E" modified="2020-12-02" version="1">MGRIFLDHPGGTRLYSCANCDTVLTNRSELISMRFTGSTGRAFLFHKVVNLTLSEVQDRVMLTGRHMVRDVSCKNCDTKLGWMYEFATEENQRYKEGRVILERALVTESEGIEEIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I172</accession>
    <name>A0A6P8I172_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Metabotropic glutamate receptor 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18 19 20" type="primary">LOC116297229</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16 17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561274.1">
        <property type="nucleotide sequence ID" value="XM_031705414.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561275.1">
        <property type="nucleotide sequence ID" value="XM_031705415.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561276.1">
        <property type="nucleotide sequence ID" value="XM_031705416.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561277.1">
        <property type="nucleotide sequence ID" value="XM_031705417.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561278.1">
        <property type="nucleotide sequence ID" value="XM_031705418.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561279.1">
        <property type="nucleotide sequence ID" value="XM_031705419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297229"/>
    <dbReference type="KEGG" id="aten:116297229"/>
    <dbReference type="OrthoDB" id="5986013at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="590"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="857"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031561274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031561275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031561276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031561277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031561278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031561279.1"/>
        </source>
    </evidence>
    <sequence length="893" mass="100189" checksum="F4F0142E74567C10" modified="2020-12-02" version="1">MNRRIAFKEIAMGVREYVTVLLLTGIFIVSHLQGGTVEGKLEMLRNPGDNVVGSIEPICVPTANSSCSDFDINGILKVEAIIYAVESINKQAQELGIXGTLGYEIRDPAQDGVYKSLLDLIETHKKPRQKPMAVIGSLSGNGLKDNLFLLLSQQMTHVSCDSTSVVNNDLIIESDIIFHVYPSDRTSIKSMVGFIAKNNWSYIGAVTDDKADSVLPALKDESIDVCVGATYKLPYYANDQQIAQFVRKMNAEKNYTVIVALTNHELTKKILAEASKQKVKGLTWVVGQRAWPNTRPIPXPNSASQGMFSILSRKSTTGFVDHLRSLSSGTKKIKNIWLRELASKSNPPLNGSSSANASAPTTAPSCDYDANPMCGMDQSKLKAAVDKMISAVEDSACTIDAVFTIAKALAEKQRCMKSPDCTEDVTKFHNFVRRLDFTNPLTRSRISFTPKGYLNYTLYHIYNYQQNYSRITTDLNKYLKAVDIGTWAYSPEVEPKLKLSLERIEWHGGHSKRQDSRCHEVCTTGKYRALKKEKVGAECCWECQRCPKDTYSDTKDALNCKKCPENERVSLTQTGCVPYFEDYVHWEHGGSLVILFLMVVGLCFSIYVSFVLFRSVDTPIMKNAKSAVPYLLPFMVIMFLLPFPLLGRPTEISCEGYRVFFILALGIPLAVLLAKSHFFDNRCKDQSNSSGMCTPRFSIVCFIVLCHVFVALILGLVIPAKVNKIPTDLPHTVFLECSYHSSHEFLVVLFYTLFLAILVAVFSLNEILSEENFKEVKWISFALFNWYTITFFYVVVSFGIHFHAKVILLALLDLFYASNIFACLYLPKWFIVVFRPEKNRSDVSPWTDYIKTQERISERLSAPEESPILAKKGTPAEKDQTPEAKGLMADTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I239</accession>
    <name>A0A6P8I239_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-uridine aminocarboxypropyltransferase 1</fullName>
            <ecNumber evidence="2">2.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DTW domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116298337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031562604.1">
        <property type="nucleotide sequence ID" value="XM_031706744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I239"/>
    <dbReference type="FunCoup" id="A0A6P8I239">
        <property type="interactions" value="1304"/>
    </dbReference>
    <dbReference type="GeneID" id="116298337"/>
    <dbReference type="KEGG" id="aten:116298337"/>
    <dbReference type="InParanoid" id="A0A6P8I239"/>
    <dbReference type="OrthoDB" id="3173at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="12">
        <location>
            <begin position="45"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031562604.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33365" checksum="AACACA16D46B559F" modified="2020-12-02" version="1">MAADSRECSSKIESKLNPFSDMKLASFEALNNVERRACAKCKSSRKYYCYKCYVVVGIDRSLIPVVKLPLQVHIVKHQLEVDGKSTSSHAAIMAAENVVIHDFPDVPEFKSKEKVVLVYPCETALTLSQLGKQSNCETENINQNIEEVVFIDSTWQQAHKIITDKRLENIQRIKIEDAKTYFWRTQRKPNTCLATIEAVYYFFKEYDKYILEREYDGRYDNLLYLFAFQYQRVQQEQRKSKRRKTSSMTDKQACCQKSRKQVLFQTLLLKCFFQNICKFYLHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2B3</accession>
    <name>A0A6P8I2B3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RPB6 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561671.1">
        <property type="nucleotide sequence ID" value="XM_031705811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2B3"/>
    <dbReference type="FunCoup" id="A0A6P8I2B3">
        <property type="interactions" value="1692"/>
    </dbReference>
    <dbReference type="GeneID" id="116297559"/>
    <dbReference type="KEGG" id="aten:116297559"/>
    <dbReference type="InParanoid" id="A0A6P8I2B3"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031561671.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14484" checksum="1E5A8686180110C9" modified="2020-12-02" version="1">MADDDMGDYDDDLDEVEEEEPLEDVDELEPTDEAGNVDILPAQDENLEPAKRITTPYMTKYERARVLGTRALQISMGAPVMVELEGETDPLQIALKELKARKIPIIIRRYLPDGSHEDWGIDELIVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2R3</accession>
    <name>A0A6P8I2R3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IST1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Charged multivesicular body protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116295470</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4. Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies. Interacts with SPAST.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559140.1">
        <property type="nucleotide sequence ID" value="XM_031703280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2R3"/>
    <dbReference type="FunCoup" id="A0A6P8I2R3">
        <property type="interactions" value="2560"/>
    </dbReference>
    <dbReference type="GeneID" id="116295470"/>
    <dbReference type="KEGG" id="aten:116295470"/>
    <dbReference type="InParanoid" id="A0A6P8I2R3"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000001">
        <property type="entry name" value="IST1 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="193"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031559140.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38584" checksum="8A0A0813698A3E29" modified="2020-12-02" version="1">MVLSGFNKQKLKTNLKLAINRLKLLEKKKTELAQKARKEIAEYIANGKEERARIRVEHIIREDYLVEALEVLELYCDLLLARFGLIETMSYCDEGMIEAVTSLIWVAPRLQTDVQEFRTVAEQLGYKYGKKFAHEASTNCNATVNERLIQKLSPKPPPKILVERYLIEIARSHSVPFEPDLSVMASEEMLDLDDLKGGRPGGNSGGGGDGGHGIGFENFNPGPPPGNPLDNLPNIPAMAGGNPGYAYPPPQSGTGITPYPPPDKGPSPGGNYPMDKKFSPYPPDPGFPSDPRKSIGPSNPAPSAPPAAPSFPDLPSVPTNSLPTNSVPGENSAGGEDVDFDDLNRRFEELKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2U3</accession>
    <name>A0A6P8I2U3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116297960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562138.1">
        <property type="nucleotide sequence ID" value="XM_031706278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2U3"/>
    <dbReference type="GeneID" id="116297960"/>
    <dbReference type="KEGG" id="aten:116297960"/>
    <dbReference type="InParanoid" id="A0A6P8I2U3"/>
    <dbReference type="OrthoDB" id="5984647at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028455119" evidence="2">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562138.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11907" checksum="1185D6CBB9CA000D" modified="2020-12-02" version="1">MLRASLLFSILLCICHGANVKIPKKTQDYLTGLTILEQPCTTMRSGLVRYIPVSHKLEVCSNRQWVPYDPVSPRSRLGLVGHWKMDEQTGDTVDDDSGHENHATASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I392</accession>
    <name>A0A6P8I392_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase PDZRN3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116295625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559367.1">
        <property type="nucleotide sequence ID" value="XM_031703507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I392"/>
    <dbReference type="FunCoup" id="A0A6P8I392">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="GeneID" id="116295625"/>
    <dbReference type="KEGG" id="aten:116295625"/>
    <dbReference type="InParanoid" id="A0A6P8I392"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16512">
        <property type="entry name" value="RING-HC_LNX3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="240"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="469"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="152"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559367.1"/>
        </source>
    </evidence>
    <sequence length="963" mass="108752" checksum="E0700F687C37634A" modified="2020-12-02" version="1">MGFDIGRFLEPVEDELKCGICFGVLDDPLVTTCGHVYCSQCLVQWIAENGTCPLTCEQLAIDDLKKIGPLTHLVSKLNIRCGYYQRGCQAILKIENLQAHQHKCQYVKDLTSGGKIMEHCDSSDQSNQVAVCEKGCGLPLLYDQEPSGHDCTQALQTNISSLQVKITKLENEKEQISERLAVREESLHERILNLENELHSYQIQALNFERQLKEYRSQVGYYQKHLEIRGEQPVESMQVEVLLERIDGSLGFNIMGGNEVGSKSVGGSGIVVSKVAEGGPAAKVGGLRVHDRIMKVNDIDLSEATHGQAVQAFKEATEPIVIAIQRKVDKNIECLNKVVSSGTQTETLAHDVDTDSGIHDRYSPRQDLLQLQRSKSLDDGTSSSEYSHRIIDSSRDDLELTNFRGGAFPFTNDLSPKSTIRSQDDSVHQVSDMKDINNVTDDNPNYMYNSYAMSDQVFFDEELDYEYEEVTLWLGAGDIDLGLTFCCGEEDESAVYICVIEQDSVAYLDGRLMLWDQVLKIDDQPVTHINDIEPLVCESTETIKFLVARPAQEVQATFIGAEGSATWECADNYGGFRIAAIKEEEEDGAETVNSEKTSGDKCEKDSGFGRTDESTKNDESSEQDTLDKIKRSKDKNNRKTRDQNVDVNTPPTTPKKESKSSRSKSSENGSSKESSSSKTVEKESSKRSPERSDKKRSNGSPTHKDKRSDRKKDKDKDKGSNERERERDRDRDKDRDREKGRDRDRDRGKHSDHRRSRRLGCVDRSIRASYMRACKDSIQTINLFGIDDSNIIKGDQRRRKSSKEESSNEAQQNEWKVRMTKDGKHIFVRKQSSTSARQARNKLLRDRAQKITEERRGLTTEDDTHSVYQGRYCPRDMRRRQLEKVREARIHRSQKLKAASDSPHTGSGSESGVGKRDLIVELSKRKMLKSNDRSFDDFVTVQELLVQRNIDGCQSGPIHVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4T6</accession>
    <name>A0A6P8I4T6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease H1</fullName>
            <shortName evidence="9">RNase H1</shortName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116296109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031559927.1">
        <property type="nucleotide sequence ID" value="XM_031704067.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4T6">
        <property type="interactions" value="1359"/>
    </dbReference>
    <dbReference type="GeneID" id="116296109"/>
    <dbReference type="KEGG" id="aten:116296109"/>
    <dbReference type="InParanoid" id="A0A6P8I4T6"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000097">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="141"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031559927.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32407" checksum="2C9EDA7C9064BD37" modified="2020-12-02" version="1">MHRSPWKLIRSLVMGKKSGKGGFYAVKIGRSTGVFNTWEECXQAVDGVSGARFKKFSSNEEALAFVGSSDHGGSSSSSSSSLRQATPYHSYSRPSTSYNSYNHVRKAPDTFKHTMPRKTQYLKTLPLSVNLSTVSESQSTEHQRPVVYSDGCCTNNGQSRAQAGIGVYWGPNHKSNISERLSGNQTNQRAEIMAAVRALQSAKDLGHRSVEVRTDSQYTINGVTSWINKWKSNGWKTYTNSDVKNVEDFKLLDKLCEDMDVKWTHVPGHSGVHGNEMADSLAKSGSRLPHQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I561</accession>
    <name>A0A6P8I561_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Glutamate receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116296215</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560072.1">
        <property type="nucleotide sequence ID" value="XM_031704212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I561"/>
    <dbReference type="FunCoup" id="A0A6P8I561">
        <property type="interactions" value="1038"/>
    </dbReference>
    <dbReference type="GeneID" id="116296215"/>
    <dbReference type="KEGG" id="aten:116296215"/>
    <dbReference type="InParanoid" id="A0A6P8I561"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000105">
        <property type="entry name" value="Eye-enriched kainate receptor, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000400">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028139504" evidence="20">
        <location>
            <begin position="27"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="821"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="21">
        <location>
            <begin position="439"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="22">
        <location>
            <begin position="449"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="856"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="752"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031560072.1"/>
        </source>
    </evidence>
    <sequence length="918" mass="103932" checksum="F03B146DC2F42F17" modified="2020-12-02" version="1">MAKNPTTILLRSCLIILFFLPNSVAALREWQPVLGVIYHPKDELLFTAFKQAIDRLNKQNLPQQIEVVSFKTYGGENILSYESTKSLRSSTCVFDLSFNDEKTYALAELLRTPMISLETIKTDIRNRYIFSLRPSDETLALATNDLMNYFFKDNRKVAIVGDVKRAHLTSRIFSIARYRNRVTPIMIPLLNSNNGRETQRGLTVLLRSNIKFVVLVADPQNISKLLERALKSGCVYSDSKWIAVDMELTGNISALEYRGLVGLRLYYDYQHKLKREAERQTRSARSKRISMASFAVLNDSIHAVSEAIRKIKQIPYYIQGDDCPIKEATGSDDRGQSWFINKLMMVRFQGLTGPVKFNPKSRDREVQLIDIMNIQAQTGMPPSFMYPIGYWKANRDTVVGSVVLKNNDVVLWNGFYWEEIRCDFRSLAARQKFNRNRKPLVITTILDSPYMMLKKNASNLKGNDRFEGFGADLIKLVADKLMFNYKIVESRETSYGSPVGGEWKGLIRELIDQEADVAVGPITITAEREEVIDFSKPFLDFRIAMILTKPTDEEVNLFAFLLPFEEQLWLCVCGVVGAVTIIMWFLDRFSPYGYRADAKNTGEGDGGEFSLSNSLWFATGSILQQGADTTPRSGSGRVLAASFWLFTLILISTYTANLAAYFTAKNTKSTINSLEDLIGQDKVQFGVLKGGSLYTFFENSKVRTYKRMFGMMKTLDTFVNSTRFGVKKAREGNFAYLTDQPSLDYYNQRKPCNTMLVKNLLDAKSYALGLQKNSEWTNELSVTLLELREEGEVEKLRLRWWDDRSECPPEDPSSSQPARLALHHLAGVFIILGGGAAISLALLLVENRCRDVMGSGRSQMAESSRDDIDGRSCNHNSLPTSGRAEMKPLNNNERRSPRPPGFDIRIPNAYATAPESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5B7</accession>
    <name>A0A6P8I5B7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">STE20-related kinase adapter protein alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562626.1">
        <property type="nucleotide sequence ID" value="XM_031706766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5B7"/>
    <dbReference type="FunCoup" id="A0A6P8I5B7">
        <property type="interactions" value="2475"/>
    </dbReference>
    <dbReference type="GeneID" id="116298348"/>
    <dbReference type="KEGG" id="aten:116298348"/>
    <dbReference type="InParanoid" id="A0A6P8I5B7"/>
    <dbReference type="OrthoDB" id="840771at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562626.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="44850" checksum="12C61865ABA3BBA2" modified="2020-12-02" version="1">MSHLCACVDKANIAVAPATPEPQDSAEQQLNMSSDHLGSGILVPFLDCKPDPHDYRITTTIGHGFDGLAKISVSLHKPSSTFIVVKQTDVDFQSSQQLEDLKHEVQVLRSLNHPNILPLFSAFIDRQELWTVFPLMSYGSCSDILSGSFPEGMPEVLISCILREVFQGLDYLQRMHIIHRGIKGGHVLIGSDGTVCLSGFRNSVKLDPYTNTSGVAFDVPLHAIDVLPWMAPEILQQDLQGYTYTADVYSVGILAIELGQGTAPYTGQPPTKVLLEKLQNPSPRLCNTRLDGSDGSTISTTTDSTTMVSTSDSKEATTSKSPKKFSSTFHQIVDICVQKNPSSRPQAQALLGQSFFKQIKKKTREVIPEYLSSVPLITHRQGNNSSDEQDLESLSAANSIAALSLDEWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I826</accession>
    <name>A0A6P8I826_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein LOC116298959</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116298959</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563411.1">
        <property type="nucleotide sequence ID" value="XM_031707551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298959"/>
    <dbReference type="KEGG" id="aten:116298959"/>
    <dbReference type="InParanoid" id="A0A6P8I826"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23385">
        <property type="entry name" value="beta-trefoil_Ricin_MRC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23417">
        <property type="entry name" value="beta-trefoil_Ricin_MytiLec-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028162951" evidence="12">
        <location>
            <begin position="20"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1743"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="1809"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="13">
        <location>
            <begin position="1870"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="2160"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1560"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1569"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1842"/>
            <end position="1869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031563411.1"/>
        </source>
    </evidence>
    <sequence length="2230" mass="246510" checksum="5115A1B0B00A1C72" modified="2020-12-02" version="1">MKAVLLVAVLGVFFYSAESLVNGKWSAWSGWSGCAPGVCAGNQRIRTRTCSNPVPSTDGAYCVGDNAEQKDCMIDGGWTEWSQWSQCENPCGGSYVNRTRACDNPKPTPDGKPCTGKNVETKLECIWPCPTEPVDGQWSEWSKWSSCPQSCGIPSGTFITRTRQCNRPPXMNGGKPCQGNATEAVKSCFTPCPVEGGFTLWSSWSRCSRTCGNGMQXRSRSCTNPLPRHGGRNCTSDYSQMKSCKLEVCPGAVDGGWSAWTSWSQCTEGKYCLRGWSSRSRSCNNPPPKNGGDECGGLGVEKRDCPTPEQGCSVYIPNRPDKVPTDPNSYIKLECDTDEKFTAKGATTASIPTALVSSLFSFMRAELQNAWFGVKIEDDKTDPKKKYTKVCIEIIDPVHILKMVNNKATYYNRTDPLPAMTKPGMYEYVTGLTVTLDEAASDYYRKLKKYEFQIATADEYVPINGFTLRDVRFSYYTEGNTMTFKAKGNYKKIPLVTFKTEVKKDVHTGSAYAIGKSSSIKFHQIMGFFGVSSSSVPDVFKNGLKKAGLWEFTMAPAEFAFKLAKGATYRFTASINAGGVPVHVEILGSLRLRSLAFAVGFSFDRESFGALTEKLSNMNIDFLKSLGIEFEIGVAFSPPKLQAVLIDKETGFSKEPLKSQITRSVPQGLFIGAQLVLPKDCKGNKFCEISKNIVGPTAKAYINGLIEWKKVTVKAGFTNIHLGEGFYFNKLELYVKADWNSTDRHVVLGFTAEVKIPVNGEVYRDGIIAPSNDLILGGNIEYDFQKHQVAGMLYFRGMWRRAFFIKWLSLGNIMFGLAYKVGAPIPITGIKFGMRAEFGYDCLLPADFKVDGHCFGGAGYFGIGSPQFYYGDITALTIGKICRMISRNIKLPEPIDVTGFPEGAKAAYATEAVDLRVAGGPYILKGFTLKGRLNIFGWSIFADLQISDTVIYIDIQPDPVKIGSIAKLVRSPSKLDVGPKFFIHMRKDPIYWDAYIEGYIEIFSISVYTRLNMTMTHMELLVQGNFLNLIKAEVFVAAEYGLRFSFDGSKFYVRVQVDLSGLNAALDAAAKAVDQAFKAAQKKLSEARQHVIEKKAECKRKMSLKCDKCRNLKCKQAERNCKGALDKFGKWVGGVVNAAGQWVSKTVKKIGKALAPVGKFFKKIFKGWRRKRELQDKRHELFSLHIRKRPVSYLCEGTCKAVEYIGKGLCNVLDVAIGFLKGVEAACGWVNKAINFVLTQLFRVHSIKFEFAMESYIGGMFKNMVFNAAVDLTIFGKRLYLSLAFSLTNPIESLRGGSTKATNWYKDKMNPKGRTDTEKEYYDKPNPFADFEMSEQFSIENQQAATDDRKGGCLYVESNAKNTFVKVTGCNDTDERQLWAYTLKGQLMNVWSRHCIDTNGASIGNKLIQTTCNPSRDDQNFQCDLVVRTVKRRRVNVCWQAGDVSLNGPGSLVHLGSLKCIHVAGGGNGVPADGTKLVIYAGCNEKRLEFALENGYLIHKGSGKCVAPTGKIVDGITLGLLSNCGGNKFSFTKGGSLQHVGSRKCVNTRSARHSLENIKQNLAHKKSTDQSSTSSNGFSERAVDENYSSDYSMKSCTHTKDENNPWWRVDLGSEHIITDILIVNRHNNFERLKNFDVRVGVHRDQSRNPTCNDRIRTVGQGQALRVQCNPPIPGRYVAVQMFGKGILTLCEVAVYSRIDIDECTETPDKGGCAQNCTNYQGGYACSCYDGYRLKPDDKGCEEIYCPELEAPFRGSILPSTCTDDRYNIRRNTMCTYQCAAGHKLANGDRSLTCNIDGTWSGKVPYCKPEVCPVLQELTNGGVIPKSCSMKNVDHGMRCVYYCKPGYELRGPRYTTCNNTQWSEPSPVSCVRVYQEPWIRCPTDIVVDLTADSNTAVLGFKWQLPVTNMKTAXVTPSNLNENYPFPAGKTRVKWTATNLDGVSKSCYYYVIVEGITCPALEHPANGNAIKTAMLLYLRCQPGYYFNPKPVGARSLTNAVYRCMMGQWKIYYNGGYQVLTQIPACAGLSSPVDGKCKAGSTRELSLCINCAPGTFHNETSDSCQECGKGTYMDTDGMTACQPCDKGYSTKTSRSAKASDCLTLCRPGSFSDNGLQESFAPCDKCPIGTYQLEEGQTSCLPCPYGSTTTATGSTSLDDCVVRASITETYPERELIVDEGGVLLLECFISGRPTPTVTWSKVGGFVIRVXFAMSVLRHIWESNKGVPLQALIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I844</accession>
    <name>A0A6P8I844_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein KIAA0513-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116296896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560865.1">
        <property type="nucleotide sequence ID" value="XM_031705005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I844"/>
    <dbReference type="FunCoup" id="A0A6P8I844">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="GeneID" id="116296896"/>
    <dbReference type="KEGG" id="aten:116296896"/>
    <dbReference type="InParanoid" id="A0A6P8I844"/>
    <dbReference type="OrthoDB" id="6268344at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039872">
        <property type="entry name" value="KIAA0513"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031560865.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30770" checksum="DEA72F705D54416A" modified="2020-12-02" version="1">MESSCSSSDQDFSEDYEDECELFERESDEFIQDFVHKIFISSEEISQELKAKFGVVCQHSCGRLSFAKHIDAQRVYCKSVDEITFYRLIQFFAVVLFECHQADDYVPAKNLMNMCFTFYHEFNLGDEVDTPQREFLSAYLRSQPIWQSMRYWNAAFFDALHCEKQVPVISSQEWDSWSSQEQLDYQECDKNSLFGKLGTFVSNMKAFGLDRDMCLQFMHKMSTIGELDKEHIRLLEKSLEDEMECLPIRSFSRASLSSPPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8L8</accession>
    <name>A0A6P8I8L8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C-X-C chemokine receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116297353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561432.1">
        <property type="nucleotide sequence ID" value="XM_031705572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8L8"/>
    <dbReference type="GeneID" id="116297353"/>
    <dbReference type="KEGG" id="aten:116297353"/>
    <dbReference type="InParanoid" id="A0A6P8I8L8"/>
    <dbReference type="OrthoDB" id="9874829at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031561432.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42389" checksum="488A29900126572C" modified="2020-12-02" version="1">MDLAEQSVQNSSFNASSSQEKLVDFRRFDIQTLDILFGSLYAFIVCVGVVGNCLVLAVVKRTSSMHSTTNYLLVNLAVADIITLLWNPRTYSFAFYSSHPRGTLGDYLCKLFTGNGIIGVAIGASVLTLSTIAVERYHALVKPLTAGKLKIQFENVRYVIAGIWSIALLINLPDFVANRFDAKYGRCICPYSLESITDFRAHVLCTVFFLGGFPLLILGFCYFQIIKGIFFEKTIMGQAQGQEDDKSKRKLAKLLLSVTMAFYTCYLPYGIFMSFLTLSKRKTLIENQNSYTILLKTVEFLVTFSSFLNPVLYAFQSSNYRNGFVKICRFKRSVLPAKENSVTFNIRDFNEKQNKIFRMAEPRLSLKIPNLSEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAJ2</accession>
    <name>A0A6P8IAJ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Deleted in malignant brain tumors 1 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116300431</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565168.1">
        <property type="nucleotide sequence ID" value="XM_031709308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAJ2"/>
    <dbReference type="FunCoup" id="A0A6P8IAJ2">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GeneID" id="116300431"/>
    <dbReference type="KEGG" id="aten:116300431"/>
    <dbReference type="InParanoid" id="A0A6P8IAJ2"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027933024" evidence="12">
        <location>
            <begin position="24"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="242"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="351"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="460"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="570"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="679"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="788"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031565168.1"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133112" checksum="687CD9ACECD84D03" modified="2020-12-02" version="1">MGKKALYSQLLWFLITLLHSGSASVIVRLNGTNSSQSEGRVEVQYRGVWGTICDDYWSLDNAHVVCRMLGFARAYITKRFGPGTGQIWLDDVSCKGTETSIDKCRHGGWGHHNCDHSEDIGVVCTNGTPNIAVRMANSSLPHAARIEIRYHGVWKSLCDGYWSLQDSHVVCRMFSYTDGAAFAIQGYQSTTGDAWDTQISCSGTETSIDKCKIRHWGESDCSSDYRAGVVCLSKGQVPNVAVRLVNGSTPNQGRLEVRYYGVWGTVCDDYWGISNAHVVCHMLNYSKALTTGTASKPWSGPILLDDVMCNGFEDSLENCQKRGWGQHDCYHGEDVEVTCEYGPRVYPNISVRLVNSSFPHAGQIEMRYFGVWKPFCDGSWTKKDANVACRMLGYSQGAALPVRGYQSTTGDAWETRITCRGTETSIEKCSNIYWKQSNCHDNNRAGVVCLTSGQDSNVAVRLVDGNKPNQGRVEVRYYGVWGTVCDDYWGINNAHVVCRMLNYSKALWTGGAKVKGSGPILLDNVYCSGYENSLESCWNVGWGEHNCGHYEDVGVTCANETKAQNPDVAVRLMNGSTRNEGRVEVRYYGLWGTVCDDRWGLADAHVVCRMLNYSKASWAGTAKIIGSGPIVLDEVQCRGNEKSIEYCPKDKWGWHNCLHSEDAGVKCEMLSKEEIKVTARLIGADHNHIGIVEVNYNGTWRPVCDDTWDILDAHVVCRMLGYKAALLGIKGYRVRKETGPWMGNVECSGNEKLISECYHRGWNNTWCPGKLYAGVMCNITNELPQAQVRLEEGNSPNSGRVAIRYGNLWGTICRDEIDINAARVMCRMLGYPGLHYKYNFKPGSGAIWLMSLECDGTEKSITDCRLGWGNATTCSHDRDVAIMCKKAEAPRFKINGTNGITDSTVIILFKRTQQSIGTQMKRVYQVAVEKRNLEKNLQSDGQTEPSAFIDDVNVTMKTSKVNNSYIAAEILGSSSSLKIGDGQYYRNYYNAPLEPGCQYRVYVRAVTKTVEKKPIYSDTTFVAFVTKRQAIANKATSGMLARRNSLEAAVIVLSIFICILILIGIGYYGWCYLRRKRAFQEKSKTEMSGQSQGNKLPETDNEPSTPHYQPLSYPSVQDNTMDEKQKPAKKLLKVVYRKKEPETSSASIVPERHEPSKSQSPYFPSDFSGIENQSFSLSDITLQELSPSQAEQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB40</accession>
    <name>A0A6P8IB40_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299856</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="RefSeq" id="XP_031564436.1">
        <property type="nucleotide sequence ID" value="XM_031708576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IB40"/>
    <dbReference type="GeneID" id="116299856"/>
    <dbReference type="KEGG" id="aten:116299856"/>
    <dbReference type="InParanoid" id="A0A6P8IB40"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="6"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="224"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031564436.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="33902" checksum="496174EF8DDD9607" modified="2020-12-02" version="1">MNSGFDVVVVGSCFMDMLWYVPRVPVQGETMHATKFQVDFGGKASNQCVMAAKLGARVAMVAMVGNDRFGHDTIENFKKYGINTDFIKVNDQLSTGVTSIAVDDDGQPTFIGLAGANKAITIDDIKQASNMIRSAPVLVCDKGIPLQIALETLKLGKELGAMTIFNPSPTIEKLSLEDYGYMDLLVINASEGEGLTGIIVDSVETAKEAVKELHKKGTRKVVLTLGEDGAVFLDDNGDQEEIVSHTKANKVNAIDTTGAGDSLLGALAYFLACYPNLPFKEIVQRSISVASFTVTSCGVQSSYPTRDELPPSLFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC08</accession>
    <name>A0A6P8IC08_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Forkhead box protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC116298773</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16 17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563181.1">
        <property type="nucleotide sequence ID" value="XM_031707321.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563182.1">
        <property type="nucleotide sequence ID" value="XM_031707322.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563183.1">
        <property type="nucleotide sequence ID" value="XM_031707323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC08"/>
    <dbReference type="GeneID" id="116298773"/>
    <dbReference type="KEGG" id="aten:116298773"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20028">
        <property type="entry name" value="FH_FOXL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047515">
        <property type="entry name" value="FH_FOXL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF411">
        <property type="entry name" value="FORKHEAD BOX PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="11">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031563181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031563183.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34385" checksum="B0F9F0410EFC4E5E" modified="2020-12-02" version="1">MFRTYSNTSELTVSHTSAMSSTTHEPEMHSHDSDMKKEDVASSPSDCVKTESKDPTKDASVKPPYSYVALIAMAIRDSQEKRLTLNQIYQYIIKKFPFYEKNTKGWQNSIRHNLSLNECFIKVAREGGGERKGNFWTLDPACEDMFEKGNYRRRRRMKRPSRQLTLQPDNGLISSYPRAAPYNYIQPKWPTYNQVQSAAVAAAAAAGSLRSAQPTGPLSYPCNPPSSRVPPGYPYVNMGSGVPVSTYTGTQYATQMQTPVNNQCGYGAVAMQNVGCRSRQAEHSPMHHYPYWSPPDKLSYDVPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC29</accession>
    <name>A0A6P8IC29_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase COP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116298217</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562460.1">
        <property type="nucleotide sequence ID" value="XM_031706600.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IC29">
        <property type="interactions" value="1944"/>
    </dbReference>
    <dbReference type="GeneID" id="116298217"/>
    <dbReference type="KEGG" id="aten:116298217"/>
    <dbReference type="InParanoid" id="A0A6P8IC29"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16504">
        <property type="entry name" value="RING-HC_COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000090">
        <property type="entry name" value="E3 ubiquitin-protein ligase RFWD2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 12" id="KW-0853">WD repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="538"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031562460.1"/>
        </source>
    </evidence>
    <sequence length="670" mass="75705" checksum="413C3FE7789B99A8" modified="2020-12-02" version="1">MARDLGSSSSGQRGAVSRRRGKRPHPPIYGGITNSFSDRNSDFLCPICFDTIDEAFMTKCGHTFCYQCISRSLTESNRCPKCNFIIEKADQIFPNFLLNELIQKYKEKNSQIKKMKIELHSGTVHSVNELQEMLGEENEWNLADVNYLLDILNQKKHRLEADSKAAQNELLQNFLTQVKRHKQEQLDQLTQEIKLIDEDMLKVKEMIENHERHYLPLTGMLLSTTDKLLPGEVDHAVPTTPTAKNAPVSVSSDVEHKGSSVELNSCDKATEDDPQDGFNGSQHGAKRLWCSTSLAARRKRIHQHFDDLEKCYFAMRQGDISTVDTSSDALEQFTESLAKFTKFSSFRPLATLSYASDIYNGSSIVSSIEFDRDFDYFAIAGVTKKIKVFEYGTVIRDVVDIHYPVNEMVCNSKISSISWSSYHKGLLASSDYEGTVTLWDAFTGTKTRSFQVSQWSIHYCXEIXNLMDPKLLASGSDDAKVKLWSTNMEHSVSCLEAKANVCCVKFNPESRYHLSFGSADHCVHYYDLRNTSKPITVFKGHRKAVSYTKFINSSEIVSASTDSQLKLWNINKPHCLRTFKGHINEKNFVGLASNGDYVACGSENNSLYLYYKGLSKQLLTFKFDTVRSVLEKDKKEDDANEFVSAVCWRTGSNVIVAANSQGIIKVLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICF0</accession>
    <name>A0A6P8ICF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116300503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565241.1">
        <property type="nucleotide sequence ID" value="XM_031709381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICF0"/>
    <dbReference type="GeneID" id="116300503"/>
    <dbReference type="KEGG" id="aten:116300503"/>
    <dbReference type="InParanoid" id="A0A6P8ICF0"/>
    <dbReference type="OrthoDB" id="10646414at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="ShKT" evidence="3">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565241.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16869" checksum="52CF8B42D68FB01F" modified="2020-12-02" version="1">MHIPCPPLPKIPAPPIHALLHHRPNPILPAPPIYPPWEHHRPQQSILDTPIHPERLVAEAVMNGAAAPNGQCVDISARCPYFALQGMCDSPSLFYHIDKVRHLCQLSCGLCNGNGAGPGFWLRKRKSKISEDGEQLQNLLDAVFSKKTENIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICG2</accession>
    <name>A0A6P8ICG2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116298388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031562670.1">
        <property type="nucleotide sequence ID" value="XM_031706810.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ICG2">
        <property type="interactions" value="2706"/>
    </dbReference>
    <dbReference type="GeneID" id="116298388"/>
    <dbReference type="KEGG" id="aten:116298388"/>
    <dbReference type="InParanoid" id="A0A6P8ICG2"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="163"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="386"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031562670.1"/>
        </source>
    </evidence>
    <sequence length="666" mass="75326" checksum="EA83D73E1AD85B7E" modified="2020-12-02" version="1">MDSDDGLMLNIVESKNDEVVASIPDKRSITKWKERRQQRRKKVTSFKEKQXLDRREKTLNNNNDCMISSNDLKLDDQDSSKTKESTKLTSKPQVISSLFRHNPEIPKVKSSSNSKDNEKEGXSDKPLFSGDKFSELXLSPHMVSNLENNLQMTTLTSIQRSAIPALIEGKDVFVKSKTGSGKTLCYALPIVHTLQKIRPKIERCDGPYALVLVPTRELALQSLGLLQKLVKPFQWVVPGFVIGGEKRKSEKARLRKGINILVATPGRLLDHIEKTTCLDLRKIRWIVLDEADRLVEKIENPASIPWFCFTIYKVTFCLKILMDNFLQLQPYYCCFSGVEKLVHMFLSDPQFVDESGTKDATDRQTNEPKNIPHAVQEDDTQNTPQQLKQFFVIVPSKMRLIALAAFLIAKHNVHTVSHPCKSIVFLSSRDSVDFHHTLLLSVLCEAEGRKFKLFKLHGNMSQSERTEVFSEYSSCTGGVLLCTDVAARGLDLPNVNWIVQYNTPGSAVDYIHRVGRTARIGTEGQALIFLTPSEAGYLDTLAEHSIRPKEVLVSDILXTLLPAEKTKPDKRGKNKDSIDHQVQDTATSLQLKFEEFVLSNVEHIKSAKKAYQSFVRSYXTFPADLKHIFHIKNLHLGHVAKAFALRDAPTGMFGQGKNKRKKEKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICX7</accession>
    <name>A0A6P8ICX7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/hydrogen exchanger 9B2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116299257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563747.1">
        <property type="nucleotide sequence ID" value="XM_031707887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICX7"/>
    <dbReference type="FunCoup" id="A0A6P8ICX7">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="GeneID" id="116299257"/>
    <dbReference type="KEGG" id="aten:116299257"/>
    <dbReference type="InParanoid" id="A0A6P8ICX7"/>
    <dbReference type="OrthoDB" id="423807at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="80"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563747.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="54970" checksum="F670636788E2716B" modified="2020-12-02" version="1">MAENTSAIQDGDQNNQGTVTNNSYLESRSHKLGFTLPPSGFLARALTRTLIAAVGWTILWTMIGDDLLPGGNLFGIFIILVFSALGGFLISNIPYIVLPSLFGMLIVGFLLRNVPGIDVAKHINKQWSATLRSIALVVILIRSGLELDPVALKKLKFTCIRLAFGPCIAEAVTVAIVVRYFLGMPWLWSFQLGFVLGAVSPAVVVPQLLVLQEKGYGVQQGIPTLVMAASSCDDVLAISLFGVFLGIAFSEGNLYFNIFRGPLELLLGVAIGCLAGLICWFLPNKKETDRSRVRFVLLSGFGLLSLFGCNAAQFSGAGALGVLTMAFIAAYKWGEEEKTPINNAMSIVWEFFQPLLFGLIGAEISLDYLDGRFVGKCVGALVICITMRMLVTFLIMAGNKLTNKEKAFVAIAWLPKATVQAAIGSLSLDIARQRGYAGKPQEEYGIQIITMAVLSILLTAPVGAAGIALAGPLLMRRVQPEEQDMRAEDRLLCIQERPNKDIALNDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID07</accession>
    <name>A0A6P8ID07_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116298721</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116298721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563120.1">
        <property type="nucleotide sequence ID" value="XM_031707260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID07"/>
    <dbReference type="GeneID" id="116298721"/>
    <dbReference type="KEGG" id="aten:116298721"/>
    <dbReference type="InParanoid" id="A0A6P8ID07"/>
    <dbReference type="OrthoDB" id="6021951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="620"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="829"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="930"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="846"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563120.1"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129690" checksum="07E7378DF8719479" modified="2020-12-02" version="1">MASVRQDVNSSKWLTLIDGNEDEASVSPTKTHPDFSSSLRQGEILIEGEFSELDNQLWVDKNVRILITSEFLYLTEKGSKNKIKKQAHVLQPEATKRVSKFSRSEIKTEIIEGCSYTFKAKWCKESRWKKYRLCGVVNEVEWQKWMNSFRLSSMESRSKDFEIPPMALPESGTNTDMSSSDDDEEEELDTEELSLPKCLPLCVDRTMSMLSMTMLNPSNVRKLAISNLQKDNSMKRASLGTIGSENEDVFEYLGAGSLLRSNSHPRLSYTKPFCTFSLMNISELSNVNIDDDLKTRKGTVESGSLDPTVVQQIKSKSIERHRRVTKYPQNVTAAELALHNRIEYLRAHPSNLNFVRRHLWDEKTLAVPSSCHHNRRLSLSLALNSDANRIPQGSENAFGICQVKQQLLRTESSPARPVYLSGIKTTGTPSKRTPVARRLNFKDDMVVEEHGLDQKPQKAKVRRFWTILNKKRPRNLPSLPDIPFSPAKEYPNDFDSSPSKLQRGKSFSAGMGRSRHSEEINCDKELRRNKVSYKSTVTSPLPARQDSVNDSPFSRKWTSPGNTGSVRKKLVQKFLSPILKSTSSEENGVGRATSPTEPPYSPDVGDELLNGWPRGLVDIDATTFAKEITLIDKELFVRILWHELESCGWMTKDKYVRSPNVMEIVEFFNRIALLVATEILSEETPQARARVISKVIQIADKCRLLGNFNSLKALMAGLQSTPLYRMKETWKEVPSKRKKKFRYLSLLMGESDNFALYRKEMESLLANGPCLPFLGDFLTQIAQTQAFMSVKRKKQKTTKPNADSKAKDSTDGTPVNGVTYSKCNGVTHASRNETKSCPATPREFSPVTSTNNVEESHDTASITCSLHDMLSRDRSKRSSSRPKFRRFHSRQNSTDNETVSLSHNRNNSSDILDVQNGRFKGKLVPASSDSVITNSDNMNGHPDSWRFGNTPRSTSSGKPPLLRRLSESSTTSFFSGGTFYGKPKRRLSESSKTSKTRRFFLDGIVRRSTSSNSVKDGRVLGHSFSTQSIREGSISPNEVMGKSVSTPIIKDGCNLLSRDISRDVSRECSCERLNESGTFDEEKWQSLVKCTETSHIGTELQLIKYQMAAVQYDFASNPDVRQFLLNASFNTEEENYRLSLKREPPVKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDA8</accession>
    <name>A0A6P8IDA8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ protein homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564102.1">
        <property type="nucleotide sequence ID" value="XM_031708242.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299570"/>
    <dbReference type="KEGG" id="aten:116299570"/>
    <dbReference type="InParanoid" id="A0A6P8IDA8"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000076">
        <property type="entry name" value="Chaperone protein dnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564102.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38543" checksum="CB0BE5F7736D48AB" modified="2020-12-02" version="1">MGKDFYKILNVDRSANQDEIKKAYRKQALKYHPDKNKTPGAEEKFKEISQAYEILSDEKKKAIYDQYGEEGLGGQPQPNGPQNTGSTHFSGGPGFTFTSYSTGDARETFSRAFGDEDPFADLIGGFGGFNFGGFGPKSRKTSQRVFMSGDDDFGSSTPKKTKVQDPPIDKDLLVSLEELEKGATKKMKISRNIIDENGMQRTEEKVLTIHIKPGWKEGTKITFTKEGDVKPGVIPSDIVFKIKDKPHKNFTRDKDNNLIYTAKIPLRAALSGRISIDVPTLSGXKIRVFNDSEIIQPGSTKILEGHGLPLPKNTNSRGNLIVKYDVYFPNYLPSDRKNNILDLLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE92</accession>
    <name>A0A6P8IE92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dickkopf-related protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116299573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dickkopf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564105.1">
        <property type="nucleotide sequence ID" value="XM_031708245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IE92"/>
    <dbReference type="FunCoup" id="A0A6P8IE92">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="GeneID" id="116299573"/>
    <dbReference type="KEGG" id="aten:116299573"/>
    <dbReference type="InParanoid" id="A0A6P8IE92"/>
    <dbReference type="OrthoDB" id="4321958at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039706">
        <property type="term" value="F:co-receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006796">
        <property type="entry name" value="Dickkopf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039863">
        <property type="entry name" value="DKK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113:SF31">
        <property type="entry name" value="DICKKOPF N-TERMINAL CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113">
        <property type="entry name" value="DICKKOPF3-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04706">
        <property type="entry name" value="Dickkopf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028175194" evidence="8">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Dickkopf N-terminal cysteine-rich" evidence="9">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031564105.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22088" checksum="F43C3D748DE3D0E1" modified="2020-12-02" version="1">MKILLVLLLVLLYVQQIQCVVYGLLLSLTATHDDKDTSNISNSTSNDAIKNDAFVCKKDKHCGKGRYCHRFYGSCHDLKPLGAHCRRDHVCSHGMECVFGKCRKAIKKGIEGARCTVDNECNMNLCCAPTHGEWLCKKMLRENDICTVPEGGLAFRINHSCPCGEGFRCNRVRQHRKKKISRLFRKERRCVRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEQ0</accession>
    <name>A0A6P8IEQ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116299950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564540.1">
        <property type="nucleotide sequence ID" value="XM_031708680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEQ0"/>
    <dbReference type="FunCoup" id="A0A6P8IEQ0">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="GeneID" id="116299950"/>
    <dbReference type="KEGG" id="aten:116299950"/>
    <dbReference type="InParanoid" id="A0A6P8IEQ0"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="36"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564540.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="59622" checksum="E59D23A5BB00D80B" modified="2020-12-02" version="1">MSKDQEMDDHFDAKQDKVYDDVFNLIPSFGRYQKIVYFTTSFLNFLLGPQFGLLVFAMSSPRFRCTTPNITCEVNKCCQNCTSYAFDEGQFTSIVTEWNLICDRAHIAATIQSCFFAGMLIGSIIGGLVSDAFGRRTCMFGSCVLLVVVGVASSFADCLSLLGLLRFFVGFFLASFMLSAYIYAIELLGPNRRAMGGQINHVFWSPGYCVTALWAYFIRDWRYLVLGTTLPPILFFLAWKVFPESVRWLIAHNRLDDAQKTLMKCGGKDGKPLNKEDVRNIVEEIRRDQVEREQKTEAKKYSVLDLFRTPKLRKRSIILAVNWFVVALVHFGFYLYVNALAGSLYINYAIMNSIYVPHLFLCWFLMQRFGRRLPYTFYMIGTGVSSLLILAVPKEYPIAVTVLALIGKTMITTEFSNVYLFTAELYPTLVRNSGIGLGSMSARVGGIIAPYIVMLSQLPGLSLTLPTTIFGVSAMVAGILSLWLPETLNVKLPQTIEEVEATKEIFKVPGCCGTSKSFEPETISLEPSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFL8</accession>
    <name>A0A6P8IFL8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LOW QUALITY PROTEIN: uncharacterized protein LOC116300699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031565478.1">
        <property type="nucleotide sequence ID" value="XM_031709618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFL8"/>
    <dbReference type="GeneID" id="116300699"/>
    <dbReference type="KEGG" id="aten:116300699"/>
    <dbReference type="InParanoid" id="A0A6P8IFL8"/>
    <dbReference type="OrthoDB" id="10069952at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="444"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565478.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="69198" checksum="7DA81FCC6DDB0A85" modified="2020-12-02" version="1">MVTDHQFEAMGLAIGETAMLRAMILPRNNDPQVNSPIQDNRKEEIRRAIDKIRNERKNVKKKEPASTKTESKVKQKKIRIGWLHRAQGARFKQVRRTGGGSIRQITYTDDNAITVEFLKSEGQRMFFPGGTSIHGPLKNMKVELGNFEQEPVDEFSDTEGKECTYPEYLRSRGLYASRSCIYLMTTEIPQQDDKKSDEKETPTSEYEPMTNVSTPKYGVYSAEGDYIDVKSNVLDITYEETKESSYSEVIMRSLSSCRHQCYDLQCLNDPFTQDTELDNYDPLENNFTVTEITKGNTCYIKRNFADTESEVSEESFSFPQCPMDHTSNEIILHPPSEVWGYDDNKLLLCVVAACHGDPAYYKWYLDGEIQIIKEGHGLCCLPVGATGDYKVEVQSKGKAEVSDSVAVKPWRSKPLPRIEEVHDDADSSLLLSKLPIIDIKDVDFNSRDEIGRGSFGVVYKGVWAGTPIALKHIKLRNAKRMQPVFEAEVQVHSMLRHPNIVQIMAMSLLKNSVYIVSELVDGFNLEDILFCDKSSEAHSHREMLLQGKVLVAKQICQAVTYLHQLKPAVVHRDIKPANVLVDKKSVATKLCDMGLSKIKTGIATTATNGVPGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGG8</accession>
    <name>A0A6P8IGG8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 189-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565811.1">
        <property type="nucleotide sequence ID" value="XM_031709951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGG8"/>
    <dbReference type="FunCoup" id="A0A6P8IGG8">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="GeneID" id="116300970"/>
    <dbReference type="KEGG" id="aten:116300970"/>
    <dbReference type="InParanoid" id="A0A6P8IGG8"/>
    <dbReference type="OrthoDB" id="5103at2759"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052601">
        <property type="entry name" value="Plasmalogen_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177:SF1">
        <property type="entry name" value="PLASMANYLETHANOLAMINE DESATURASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="8">
        <location>
            <begin position="89"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565811.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31373" checksum="A4A3FD06A68915D9" modified="2020-12-02" version="1">MAPGNTPVSEVGKKEMTSEKTTVKYNSADKPKAGAKAELADGYTKEKRILETFSVLYFAILMSVLTSCLLKNFKVDQLQGMILGIFAGILTADFLSGLVHWGADTWGSIDLPVVGKAFIRPFREHHVDPTAITRHDLIETNGDNCLITLPTLTAITLKHLICSQETIDAWYPWDFFFFSLGIFVMLTNQIHKWSHTYFGLPWWVEKLQQWHIILPRLHHRIHHVSPHETYFCITTGWLNYPLEVINFWRGLEFVITKTTGAIPRSDDLNWASKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGX4</accession>
    <name>A0A6P8IGX4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH2 domain-containing adapter protein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116301059</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565920.1">
        <property type="nucleotide sequence ID" value="XM_031710060.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IGX4">
        <property type="interactions" value="963"/>
    </dbReference>
    <dbReference type="GeneID" id="116301059"/>
    <dbReference type="KEGG" id="aten:116301059"/>
    <dbReference type="InParanoid" id="A0A6P8IGX4"/>
    <dbReference type="OrthoDB" id="5914531at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF32">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="392"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
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            <begin position="14"/>
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            <begin position="41"/>
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            <begin position="96"/>
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            <begin position="352"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <sequence length="499" mass="56621" checksum="C96542322EBB06C8" modified="2020-12-02" version="1">MAGIGKLFKFGSKKPPELPRKDYDDSEEEGYMDPSICHSAIPQSSGSLSSKMPNYPPPRPNHPSIAPKPVDNTFRSQYRNQGEGYKPPIKPRPVRTQRNAEGNQSKPVDDYCDPWDAKQRKPKMTADDYCDPVDVTRPAQAKGKIDDYSDPWDSRPGHITKPKVKKTGVKDEYIDPWDXKGPQNLNQEKPDSDDDSYTEPYDSGKVTALDEQAKRLSLRGMRLPSAGNAEHDQNIKYTPQTHFEDNRPTDDYASPWESKGLILPSQTSIIKQTQAKVGQMPLSDERPCEDYDKPWEWTAKQQMHQYINGPVSDPNPTNTQSTTQVPVVDSRPENDYDAPWEYNKRTSQLVSMAQEQAKSDGSSIPPKPSRVGIDDDLTFTIDLSLPLEKQSWYHGPITRVEAECLLKHEENGSFLVRDSESSGKDYSLSFKNNNAFMHLKIAVNAQGKYVLGQFSLPYDAVPEIIDYYSRNKLNIRGAVHSYLKNPIIPRHDYFVLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH79</accession>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Aftin-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16156:SF10">
        <property type="entry name" value="AFTIPHILIN-RELATED"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </location>
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            <begin position="948"/>
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            <begin position="47"/>
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    <sequence length="1091" mass="118162" checksum="AC12E7BF86647E53" modified="2020-12-02" version="1">MSFYASQFNDKSSRYCSSNLYGSNLSTVYADGPPPLDDTLEEDDGEIVFRDKSPRKESPEPKLVKDEKGTVSGESDFNPWSKNDATKDEAVDDFGDFSGFADFSSAFGGGDSNSQNDSSWFKNGDNDQSSVTKFNHDFENHEAEISASSRKNVKKAEERTSKNDDFGCFSGGDDSDFDDFCSFTSNSQHINTGKSEESSSKDSQTRKDSESKKTTNSDDLIKKVKTIHGSSDKFHYSLEQNAKTSNFDSVDDFDEFGSSEGGSTLNQRSVPPINDSSNSHAQNITSGTHSAMKPTCFSDDDDDFGDFSSSSFDDDSGGTAKTPELIIKSETNFSSQSKDKELQNTHLNGSSIESEHNPTDSKDNNEPVSIPQHNGSETDLKKNEDISMSDRDKDFINTDQSKENITLDDKDDDDEFGDFSASISSVTKTEETKTKEMPSNSIVQDDDDEDFGKFGSPPSLSNLQGDDDDFGEFGAVAAPSKDNNKNDDDDFGEFGAVAAPSKDNDKNDDDDFGDFGAASPPGLPSLHGNSDNEDEFGDFGSGINKPSSQSNDCDGEEFGNFGVLPTSTSAEEKPKTDNDDDDDEFGDFGATFPSKETGVAKLTATEEKTKSNDVDELGDFDAAPVTSKSNLHSSADAAAAAAAADDDDFGAFGSAPATNKPDLHGNDDADDFGDFGSIPTTNNPDLHGNNDDDDFGDFGVASPTSQQNKNDDFGNFPEVKQPNSKDSKSKSTSEPSSLESRVNPPNDEDDEFGQFDAAPSKSSDSDFAGFKSSDKTSKGFADNSSMPQKSILSPFSATNNSQSFSNKDVLQEQPSKLSGNTSVIKPQCNTNLDRLENPIKKCFTIKDVTMQSNVIIQMIEHQVQSERSKAWQQLLTSEKDGSLRFDWVLSEHQVKMLEGLSMLPVKIQTSVSFNPKGQVPTPLFASSMGLLEPVKGVITPFHHVEEINPSQDPFGAPPEVGVQDLGFGKGSKKEHSTLHTESKDNASDTISVSSSLDLDFLAPSSTNGDSTKTESRGLFEDDLLGLGMFNEPSPSPKITNGKNVFKFNNITIPLATNEGNLSEQAKTVVKDFEDLTFMLSKVLMFPLKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHW0</accession>
    <name>A0A6P8IHW0_ACTTE</name>
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            <fullName evidence="9">Cannabinoid receptor 1-like</fullName>
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        <name evidence="9" type="primary">LOC116301244</name>
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        <name type="scientific">Actinia tenebrosa</name>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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            <begin position="43"/>
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    <sequence length="354" mass="40571" checksum="64A8E19BEC98F334" modified="2020-12-02" version="1">MAFGDNTCLFVQGDIFIEGKTAFITDVLTAVLNALFAIIAVLVNGFVLYIIRRSEHLKNAPSNILLCCLAFSDMIIGLICQTSFVLYKVCELLKSRDIFCYFRLIVSCFGWVCAGVSLLTISSIIVDRLLALRLHLRYNTFVTAKRVYCLVVIFWIFCIFMVSLRFSFQSDAHWTLIPLVLLIIALVLTLTSYANIFCIVKQHHTQIIDLENSMIRRNHPTEDKAFKNNIYLIRYKRTAATMIYVLAVFLICYLPFLCTMFAEASLGYVTQVKIAYDYASTIVFISSSINPVLYCCRMREIRNAITNSIWVLTKWDFRRGSNVGRRIPKSVHRFIEVKPCSGSASHSENRKERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKF6</accession>
    <name>A0A6P8IKF6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116302156</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
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        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Actinia</taxon>
        </lineage>
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            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
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    </reference>
    <dbReference type="RefSeq" id="XP_031567237.1">
        <property type="nucleotide sequence ID" value="XM_031711377.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A6P8IKF6"/>
    <dbReference type="GeneID" id="116302156"/>
    <dbReference type="KEGG" id="aten:116302156"/>
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    <dbReference type="OrthoDB" id="5952164at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="DUF4773"/>
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        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028125030" evidence="1">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="67"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567237.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21474" checksum="E9858A502409E526" modified="2020-12-02" version="1">MARLLGILAFLCILGKLAALGDENSPKVVVFGEGDFEVKSDEGARDSLVWQATKGQKPVALRIEDRKCQCSGTSCNCCAKINLVISTMSVCAGFTFNPSAKTLDFTVTVDGIVVFKKTISVDKPVKYCRDFPIGGKNANICLGLSDISFKEGHTGACIYIEINYKFIHWKQDLGCIYEVVQPINNTKLKAISFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILF5</accession>
    <name>A0A6P8ILF5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Methyltransferase HEMK2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">HemK methyltransferase family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysine N-methyltransferase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methylarsonite methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein N(5)-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302166</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16223"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer; heterodimerization with TRMT112 is required for S-adenosyl-L-methionine-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567248.1">
        <property type="nucleotide sequence ID" value="XM_031711388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILF5"/>
    <dbReference type="FunCoup" id="A0A6P8ILF5">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="GeneID" id="116302166"/>
    <dbReference type="KEGG" id="aten:116302166"/>
    <dbReference type="InParanoid" id="A0A6P8ILF5"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="17">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567248.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23401" checksum="42DBE7FE89937EFA" modified="2020-12-02" version="1">MANIPTPVISHLSSKDYQDVYEPAEDSFLMMDALEKDVEFLKERRPTLCVEVGSGSGVLISFLASILGNSAYYLTTDINAQAAVCTRKTVDVNGYHVCPVVTNLLDGLIPRLNGKVDVLLFNPPYVVTPSHEVGSFGIEASWAGGVKGREVIDKFLPLVPSLLSKTGCFYLVTIAENKPEEIKKLLQDLGNLGCTTVMQRRAGPERLSILKFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILR7</accession>
    <name>A0A6P8ILR7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116302572</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567764.1">
        <property type="nucleotide sequence ID" value="XM_031711904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302572"/>
    <dbReference type="KEGG" id="aten:116302572"/>
    <dbReference type="InParanoid" id="A0A6P8ILR7"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948:SF1">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031567764.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="61941" checksum="F10A76776EB115ED" modified="2020-12-02" version="1">MEEKLPSEGTPIVASADDEDVNDESNEDQGHFKSKLGLVLSCLGCVVGTGNIWRFPRIVANNSGGEGCLQFLIAWILFLFIWSIPIILIEYAVGRYTRKSTVRSFRILIGPWSSWCGAWMSVVNTIIGCYYSVVLGWCFYFLFRSIFYKLPETIEESLKTWDAMQDSSXPIFCHFLSILLAGLCISREVSSIELVNKIIIPILLAILVFSFYWALSLKYAEHGIKYLFTXDWEEFKEPRLWVDAASQNAWDTGAGVGLFLTYATFMTKKNGVVKIGTLLPACNNLISLLCCITTFSTVFSVEMNRDSPKSKEEIVKLLKDNGKANTGLTFIWMPLLYNSIGAAGPFLCALFFICLALAGXSSLISIVELAVHTLQDMEVPRRYAIPISVTVMFCGGLASALDLDILVNQDFVWSFALIIAGSMTLSIPIRYGASRFRDTVVNKFGYDDWXLPFLWQIIVKYIAPLEALGLIIWWIIDTVNSEKDKDGLHWYELDKESFMMAILQWCVVLICLVSINAAWMHWRRSRXEDYAAIPSSYGATEQKPSGPSSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM79</accession>
    <name>A0A6P8IM79_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116302694 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567902.1">
        <property type="nucleotide sequence ID" value="XM_031712042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM79"/>
    <dbReference type="GeneID" id="116302694"/>
    <dbReference type="KEGG" id="aten:116302694"/>
    <dbReference type="InParanoid" id="A0A6P8IM79"/>
    <dbReference type="OrthoDB" id="10390264at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567902.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="52645" checksum="34C8F4F93E9965EC" modified="2020-12-02" version="1">MMTSMRTAYDDLYEDSAPLRFISIRLSEFGNRMKHSVPYLIYKEPDYMMTLSERTRLNILLCLSVILAIFQVITATAVIILFKAYSDLKKKATETETNLSSIETQISLRNEERPETTATTATVESERNSRKWRGNVEESPTRVPTPPQNRRSGYKQEIYPQYYSTEVPRTQSRNSQEMTGFPRDTSFTSARSCDSGTGSFITRTPQSSISCESKTLWQAPIIERGSNEVKDRPISRDSQISQSPFRLSRDTSSEVWRTGSSGSSQSLEDKSRRARREVRKECNEPSNQNELTYNRSSRLHTMAIEMIGLEENGLTNKAYHEGNEDFNKGLKKTAIASEELAHDLNSESQPQIGKNVNTADLNYEKEEIKKKWHKDENEVPTRVPTPPRMRRSKRNKNEVRDRLSSRLETMAIGMIGLEETHAGERKSERLSRHLIQRKEEIGEESSDLNGNKSNVITRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INK4</accession>
    <name>A0A6P8INK4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-lysine methyltransferase METTL21A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116303088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568402.1">
        <property type="nucleotide sequence ID" value="XM_031712542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INK4"/>
    <dbReference type="FunCoup" id="A0A6P8INK4">
        <property type="interactions" value="1536"/>
    </dbReference>
    <dbReference type="GeneID" id="116303088"/>
    <dbReference type="KEGG" id="aten:116303088"/>
    <dbReference type="InParanoid" id="A0A6P8INK4"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031568402.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32251" checksum="5618A52696DE7AE3" modified="2020-12-02" version="1">MELAHKQRLIKYCLILSSFSKENCFPLIKFFVFRDLSLSMGSLSSYVVLLLSFTKFLPFIITIQKASASMALVPYSPHKTLGIFHKSERNFTFVGRTLTIHQDWEEGGVAAVVWDAALVLSQYLESKGNWIKDKKVIELGAGTGLVGMVAAILGGDVVVTDRKAALNYTKTNVKNNLKILSDTSLKVTALDWGQDTSIFSAPYDIILGADIVYIEETFPNLLKTLTDLSGNESVILLSCRIRYKRDNDFIRLLKTKFNVKKISHDRNVDIKVYEATKFHIVTAKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR01</accession>
    <name>A0A6P8IR01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Leucine-rich repeat serine/threonine-protein kinase 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC116304006</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031569514.1">
        <property type="nucleotide sequence ID" value="XM_031713654.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569521.1">
        <property type="nucleotide sequence ID" value="XM_031713661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304006"/>
    <dbReference type="KEGG" id="aten:116304006"/>
    <dbReference type="OrthoDB" id="1866797at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="10">
        <location>
            <begin position="496"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1217"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="911"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="935"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="953"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031569521.1"/>
        </source>
    </evidence>
    <sequence length="1870" mass="211521" checksum="6C9A1429CBECF2E1" modified="2020-12-02" version="1">MATNNNRLYNACEKGNYDEVEARLLQEDETSKSKLLRKYFDISQNTLLHIAVINGRSRIVKLLLRHGACVNLTTGAGKYTPLHLAASTGQTECVRILLEQQDIVLSPKDDFKNTPLKGSKNETIAKLIKSKEVIKAVQRNNVERLEVALCGAQKNTFTEVCFSRALKVAVCNNQVKTEIIFKILSFAADNSCFSDLELLDCIQLVFAQDNFNVEITALLVLCWLASVEGEIWQLNFFLGISADDWLQDQSHDATLDQLEVIHHHKFHEIREMLKRKKCKDFSPAINIAMACKHTKACQMLLGHGSMHEKMCEVRWQCLGIPTLTAQIFKAILHRGPLGVCKWNNITLLDLRRNNLETIPSMIFHLPLLGTLYLDNNKLVDLPNAKWISDSLNRLYLSHNQLSHLPSVLGSSNLRTLYLDNNMFRSIPECVCKIAGLETLDIIENQLEWIPLEIGLLSKLTSFHFDPNKVVSPQGISKFRVETTKELVTWLRSLLVKMKPYTTVKLLVVGWQDKGKTTLVHRLEGDFKYFEREVTQVLKLVTGVEMSEFRMQQKMMVVVPTGPKVKFQVWDFAGQEDFYLMHMCFLSSVALYLLVWDLQDGEIGIEELKTWLDNIACKAVYPTTVIIVGTHLDCIPGNQAKDYTERMRELVNNMIERRPRDKIHVACVVEVSSHPQRCQGLENLRDRILKAAKEMVKDKNVRVLDQPVPISFHELVTKIEKMRNKMWMNKELPILNLDQLWSLVKETLGFKEKRFPEDEFKEAVEFLKNRGVILHFDDPNQDLRELYFIDPGWLFTLMTRAITSQSSKDGLVRKDSLFVENEEASFTEKSRERGILLLSRFYVVHILDQDTLLIPSKFSKIGPEKKMKGKKRLRRIYKMEYLPHGFFSRLIARLLHYLNSMIVEAFKDQEVMPSSSSSPLTSTSSSSPSPSPSPSSPLSSNQIPTPTTRPTPRFSVQQNPTTLTKQHQQLSPPWPSHPPRVRTPSTATTTASTVSEIGTSRAATATPSPPGSESSSSSVSPSLSKPEPIVTSLSPLPATKLVSPPQPNQTSFSPRPRVNPHSSFPEVTTVTNLREADILHWWRNGIQLNLPDAFLEVTLQQEANKSPRIVIKASRSVPGKRLLVFTIEHVEALITEWFHGLREGRVSQFVPCVVCEDKGLEDSNVFTLGDCLRASNNSDCIECPKHKDAPVPISDIAPDISLHDVHPDLLFQRHQLHYDESSNIKEGSFGKVYCAVLKKSTGSEKLVAIKEFKGDELTSFRELRKEINVLRRVVHPNLVQMVGVASKPRCMALELAEGSLEGVLFDKDSEKIPRLVLIAIAKEIANALAVLHWHKIIHRDLKPSNVLVYSLKEDDTVHVKVSDFGTANFTGPYGMRALVTRTHIRAPEVLEFALKEEYSVEVDIYSFGILLFAMITRERAFNDVPSNDIRSCILEQKRPSWRHAEGAMDVLVNLTRLMCVSWNQSSQDRPTAVQCQKQLENPGFQALMSKLAFPSANIVVFLHFFPCNEDLWVVHTINGFTFLSVFTGSFGLNSTQCFEICRNQDQEIEAICTHLDTMVVTLKKMTNLTRIFKIYSLTESSLLTTMACDSLPAINSMAATITHIFIGTDLGCFVTDIDRQTNGTLTANHLTQKPVESILVTNSKLWMCDKSSVTVYSLLEDSQFVPFYDHKDRFIKGIYPLAHAQLEEDTIWILTEDSVLKLNAEAQILCLFEVQDLFPSQTIELSVQSHVTCLLPANDTLWLGLFTGAIVILDINTRQIITSFQPYTEAVAHMVSSPDTQPPMVISCGRSPSGFLGTDRDNVIHPLAVDTSEMVKIAARKPSRVLMNVNTSFEGNWEEVQLEEFSDVLFAWHAMSCKSWKRIQRAQSNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR77</accession>
    <name>A0A6P8IR77_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569626.1">
        <property type="nucleotide sequence ID" value="XM_031713766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IR77"/>
    <dbReference type="GeneID" id="116304105"/>
    <dbReference type="KEGG" id="aten:116304105"/>
    <dbReference type="InParanoid" id="A0A6P8IR77"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569626.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25193" checksum="0664AFDDBBE741EC" modified="2020-12-02" version="1">MLRYSVGKMGICLSDRNQVKDEDPDVRGFRKPPHYRNREGPKYRVVNFTPDYEYRKYEPSTWICVRVNGVEFKKAADRGESILAKYFDGHNGPEKTMNKTCPLKVQIEFKQDLHEPGYFVVAKHLPYEYCDRPPAPKHKDMFIQDLPEHFAYVSVFGGIADQNEIKQRLDALIEVLGNENKDYEKMDYSTTRFEKAYNLRKNTNEIILLTNRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRR4</accession>
    <name>A0A6P8IRR4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116303526</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568943.1">
        <property type="nucleotide sequence ID" value="XM_031713083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRR4"/>
    <dbReference type="GeneID" id="116303526"/>
    <dbReference type="KEGG" id="aten:116303526"/>
    <dbReference type="InParanoid" id="A0A6P8IRR4"/>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568943.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61756" checksum="F67E338EF3D3D2B0" modified="2020-12-02" version="1">MSYDKENLGGDDGGDVKIVIRGNDHKAQQGPNSIYAFCNHCKKDISVVYIKSENNGKDVCVSESLSPKWSVRNNHGDYQENDYDKCQKDNNYEGCRKLLDEKKKKRKIGEMWENFLGSCTLHGFHYCFSGNPPLRRIVWTILLLTAFAMFFEKCSESIKSYFEYPFTTTTLLTYTDRLPFPAVSFCNYNDARLSKMNGTIMNEIFVQSVLEGKNVSHLKAKLNGELMKKTLKDAAHRLEDMIKECTWQESVPCSWQNFTLFKTADGDSCYTFNSGKMGEILKTTTVGSKEGLRLLIDIQHVEYYYDVKNAGFTVILHDQEETPVKMQGISVAPGFATYMELKRRKVTNLPLPYKTACGMPKLKYFDTYTKSKCFLDKLTRYVDAKCKCRDWFMPGEGEIPVCDLTTAELCLWPAWEHFETKKLDNCPIACDSIEYSAQLSYARFPANTYAQMLARQYNLTGTPKENREYLRDNLMELKIYYEDLTFSDVRQVPSYDLFGLLGDVGGQIGLFLGASLLTIVEYLDVLGMMAYTSYKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRY0</accession>
    <name>A0A6P8IRY0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase</fullName>
            <ecNumber evidence="1">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031569906.1">
        <property type="nucleotide sequence ID" value="XM_031714046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRY0"/>
    <dbReference type="GeneID" id="116304326"/>
    <dbReference type="KEGG" id="aten:116304326"/>
    <dbReference type="InParanoid" id="A0A6P8IRY0"/>
    <dbReference type="OrthoDB" id="6149684at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000022">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0801">TPQ</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="4">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569906.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35331" checksum="44424211E9716AE5" modified="2020-12-02" version="1">MAKVSPLWKWLTILFIIISIALLIALIVVASKGDKKKEEAAVCASGMDVSVTLSSASGPPHQGLFDDLSALEIKKVRDYMFQVKPLDLKPNQELKINSNRIAIIQLYPPSKDDALAYLDQKKAMKPERQAIVVVFRGASQPAVVEEYIVGPVDAPTKHTLRKVDGREYPINFNARPFSTQEGIVLHNVIFTDVGRKAHDLINESYDGYSYGDNCVEKCLFVQFAAPMGLTSKTRDNWFGFYRHDLPFYIHPLNFEFYVNHAGSDPSKWRVEKVLYNDQLFDSVEELMAAYRNASLIKTFIPALSDEEKKGQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITJ6</accession>
    <name>A0A6P8ITJ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116304008</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569513.1">
        <property type="nucleotide sequence ID" value="XM_031713653.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ITJ6">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="GeneID" id="116304008"/>
    <dbReference type="KEGG" id="aten:116304008"/>
    <dbReference type="InParanoid" id="A0A6P8ITJ6"/>
    <dbReference type="OrthoDB" id="5984420at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF49">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569513.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15520" checksum="8E38D65889E67B4B" modified="2020-12-02" version="1">MSDCCHSRXYHSXGRTSFFLAVTVIGWLIVIALFVFFFLSLTXXVPQVNWKLANLITSIVFAVLLLICSSLMAERADXLSYWKKYAYYDHYYAQIWNTMTAAVVFGFFSIIAFIVDAVFQFMGLSPGGGGGQVSNAQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV40</accession>
    <name>A0A6P8IV40_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable ATP-dependent RNA helicase DDX46</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">DEAD box protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116305204</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031570919.1">
        <property type="nucleotide sequence ID" value="XM_031715059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IV40"/>
    <dbReference type="FunCoup" id="A0A6P8IV40">
        <property type="interactions" value="3145"/>
    </dbReference>
    <dbReference type="GeneID" id="116305204"/>
    <dbReference type="KEGG" id="aten:116305204"/>
    <dbReference type="InParanoid" id="A0A6P8IV40"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22473">
        <property type="entry name" value="KH-I_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000584">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="454"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="643"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="136"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031570919.1"/>
        </source>
    </evidence>
    <sequence length="1081" mass="124032" checksum="51E861DDEDDBC79A" modified="2020-12-02" version="1">MGRDSRRSRRSTSPSYERRRRSRSTERDKRKRSRSRDRERERNRDRDQERKRDRDRDRDRERGKEREKIRGRKRDRRRSKEKNRKRGHSSSSSKSSSSRSRSSSSEKKSRKRRSRSKSLERKRRRRSRERKRKSRSRSDSSSKSRSRSRERESKKSKSSKDKRKQDDEEIQDKDKKNKESEKETSSEAIDKISEQNQLDLEMQKRRERVEAWRAKKKREQEVQDAQKRVQEIRKNKVWSLEDDEEDDEADNVIDEENKDEEKDDSKDGTNGNVKEEDEDVDPLDAFMATVNSKAHKENPLAHKKVGKGKATFVTHVVSKKSVVTKSAGKRGELMEVNPDALEYSSEEEKEEEDLEATYSGYKTKKKKDLQPVDHNKVYYSSFRKDFYVEVPELAKMTPEELDEFRLSLENIQIRGKNCPKPVKTWAQTGVNLKILDVFKKNGYEKPTPIQAQAIPVIMSGRDMIGIAKTGSGKTLAFLIPMFRHVKDQPPLDRDDGPIAIIMTPTRELAIQIHRECKKFSKPLNLGAVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLTANSGRVTNCRRCTYLVLDEADRMFDMGFEPQVMRIIDCIRPDRQTVMFSATFPRQMEALARRILDRPIEIQVGGRSVVCSDVEQHVMVIEEDNKFLKLLELLGVFQEKGSVLVFVEKQDSADTLFKDLLRRSYPCLSLHGGMDQFDRDSTIADFKNGVTKLMIATSVAARGLDVKHLNLVVNYDCPNHYEDYVHRVGRTGRAGNKGTSYTFITPEQGRFAIEIVKALENSEVLVPDELRNLANEYIETQQAEGKQITKTSGFSGKGFKFNEEEVNKVNEAKKIQKWALGLQDSDDEAEAAEKEVEEIDKRLDAVFSKKPHIKKVVPAVSEAVIKGEQKAKLNLAASIAAKINQKISAGTNTLDPTQQAASQIIKGGTVTALTGLDLAKQLAEKIHSKLNYEGPQEEPKEQDQKEVEAERYEDEVEINEFPQTARWKITSKDTIMAITEYSECAVTVRGTYFPPGKEPKEGERKIYLYIEGPSERAIQLAKVEIKRIVKEELVRLGTFRGPQQTGRYKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWF1</accession>
    <name>A0A6P8IWF1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116305572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031571372.1">
        <property type="nucleotide sequence ID" value="XM_031715512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWF1"/>
    <dbReference type="FunCoup" id="A0A6P8IWF1">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="GeneID" id="116305572"/>
    <dbReference type="KEGG" id="aten:116305572"/>
    <dbReference type="InParanoid" id="A0A6P8IWF1"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="132"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="292"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031571372.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="57953" checksum="D4C9368F56D23A75" modified="2020-12-02" version="1">MASPVFLGFDLSTQQLKALAIDNDLNIIHETSVHFDNDFPEYKTQGGVHKHEDNLTVTAPCLLWVQAWDLLFDRMKCKGFDFKSVVCMSGTGQQHGSVYWKKGAKEVLKFLKSGDSFYDQLKDCFAVLDSPIWMDSSTSTQCHSLEKAVGGPKRLAEITGSRAYERFTGNQVAKIFQTQPKVYDQCERISLVSSFAPSLLIGEYAPIDYSDGSGMNLMNIETKDWEDKCLEACAPHLRQKLGPLTSSCSQVGNVSKYLVDRFGFSPDCKVVAFTGDNPASLAGMRLGEGDIAVSLGTSDTLMLWLKTPRPALEGHIFVNPVDTNAYMALLCFKNGSLTRESIRNSCSNGSWEQFDEALNSTTTGNHGNIGIYFEVKEITPFADGIHRFSENNDKVESFPKDVEIRALIEGQFMAKRAHAELLGYSIGPGSRVLATGGASSNKSILQVLADVFNAPVYTIKDTANSACLGCAYRAKHGWLGPDHSFKEAVSNAPAYQLAVKPRADAHEIYTPLTSRYIALERSITTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXJ5</accession>
    <name>A0A6P8IXJ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAS-associated factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572121.1">
        <property type="nucleotide sequence ID" value="XM_031716261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXJ5"/>
    <dbReference type="FunCoup" id="A0A6P8IXJ5">
        <property type="interactions" value="2854"/>
    </dbReference>
    <dbReference type="GeneID" id="116306208"/>
    <dbReference type="KEGG" id="aten:116306208"/>
    <dbReference type="InParanoid" id="A0A6P8IXJ5"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16120">
        <property type="entry name" value="UBX_UBXN3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="369"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572121.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52618" checksum="5819625E5EB1FC42" modified="2020-12-02" version="1">MAAPEDNLNEIQLGVLSHFQDITGMEDVDECTAILERHQWDIETAVQDTFNKAEGAATVFHEEPNEVDSPPLKNGTTGSSNVVAANTERTDQAVDVHRPNMGWCNWMFSILLLPFRFTSSVVTNVFSFIMTLVWPSFYYPRRTALDDVLHFKKEFEEKYGTVHPNFYQGTYSQVLNDAKRELRFVLVYLHSDDHQHTPAFCRSTMMNSGFIEYVNGCMLFWAVDVRSAEGYRVSNALRETTYPFLALICLRDNRMTVVGRMEGIMPVDRYVSILAQLVADNEPALIAARVERQERSQTQTLRDEQDQAYHESLKADKEKERRKLEEQEKKRKEEEAIRLKEQASQNKLESIARSRVEKREQLPEEPSPSDPDVFRVLVRLANGTRLERYFLKSHKLQTLYDFVFCNEEAPAEFRLSSPLPKKVYELNNPDYTLEDVGICSSVTLYVQDTTEDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYP7</accession>
    <name>A0A6P8IYP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116306696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572641.1">
        <property type="nucleotide sequence ID" value="XM_031716781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYP7"/>
    <dbReference type="GeneID" id="116306696"/>
    <dbReference type="KEGG" id="aten:116306696"/>
    <dbReference type="InParanoid" id="A0A6P8IYP7"/>
    <dbReference type="OrthoDB" id="5950937at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572641.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19284" checksum="31BE2EB71398A67E" modified="2020-12-02" version="1">DKRIMRRFGYSFRGCPAQSLRWYGNWGPRITAIPVICSEGIIELNIRRGTTDEESFLAFVNEKLIPNLQRFDGINSRSVVVMDNAAIHRCRRVVEAINTTGALIVFLPAYSPDFNPCENIFSQAKSWIRANDVVWQVCHDPEEMVFEAFMQVSDVDIRNYLRFIGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZD6</accession>
    <name>A0A6P8IZD6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptor GRL101-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116306611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572554.1">
        <property type="nucleotide sequence ID" value="XM_031716694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZD6"/>
    <dbReference type="FunCoup" id="A0A6P8IZD6">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="GeneID" id="116306611"/>
    <dbReference type="KEGG" id="aten:116306611"/>
    <dbReference type="InParanoid" id="A0A6P8IZD6"/>
    <dbReference type="OrthoDB" id="7743103at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="223"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031572554.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58747" checksum="0991643FB1B74D2C" modified="2020-12-02" version="1">MHVCEMKSLMAGKNNVTHLYLTHNSLQELPDGSLVGYPHLIYLSLAYNNISTLTYKAFEGLKNLTTLCLSHNPLRSIKGNLSGLLSSLSVLYVTGVEYWVLDKPLLELPKLKHVTNVILPSYKSEGYCGYCSFNRSNLTWTPLAPFVDKSGCYLRRHSVNMLSSVAQLLNGSYFHIQCNNRNIFKCKHNKINFYTYYIENSCWKEMLIVIKCQSAVGCFVALLNLLVFWNIMTSKYLRKNVSMLFVGNMALSDLLIGVYVLRIGVYLSGTTYSYFDYESRHDCQLIGFLWMLGQAGSVITSFLLTLERYLVIVYSLNPNIRITRRMAMILIFVCWLLSAFFTCWCFYYELYQYSYLCIPIRLSIDKKEKIFVFTLTIGSIGIFLCLISFIFYIHIFVTVRRAAQRAGVKRESKLAKRVAILVGSNIIFYIAPVLFSGITFLSSSSSKNMSALQQIATEIVSLFCLCVNSFLNPVIHAFRTDLFKTVLKERFSVALLTFRSGFVMRPVNQPTNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J081</accession>
    <name>A0A6P8J081_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116306860</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572844.1">
        <property type="nucleotide sequence ID" value="XM_031716984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306860"/>
    <dbReference type="KEGG" id="aten:116306860"/>
    <dbReference type="InParanoid" id="A0A6P8J081"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059">
        <property type="entry name" value="ANTHRAX TOXIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059:SF25">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="6">
        <location>
            <begin position="141"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572844.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25964" checksum="EEAAE909B1E12D33" modified="2020-12-02" version="1">MRYLRILRINRIDGIGINMMKLFVVVALLSITGMECNDEEVKRTFEEYKHLGCYADKAARAIPKHLWTYIFTSPGEAVRKCAELAESKGYRVFGVQYGGQCFSGXSAEKTYDQYGSSSQCSSGVGGSWANDVYAFPEEHHIGCYKDEKEDRAFPKYLGKFPAQTAVSKCADLADKKGFPVYAVQFGGECWTGPESEQDFDKYGKSNRCKNGVGGILANDVYSLKRKYTSYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J369</accession>
    <name>A0A6P8J369_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031574044.1">
        <property type="nucleotide sequence ID" value="XM_031718184.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J369">
        <property type="interactions" value="2116"/>
    </dbReference>
    <dbReference type="GeneID" id="116307866"/>
    <dbReference type="KEGG" id="aten:116307866"/>
    <dbReference type="InParanoid" id="A0A6P8J369"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574044.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="59232" checksum="1E511CE07595BDD5" modified="2020-12-02" version="1">MRDKKNVDLASKFHSVLRLPTSMDLEKLRENLKGYGQEHTLKYWDELDEEQQTRLYNDLESIDLAKLNHSFTITMKEAENHTGEKKDERITPIPPKQIGSVARAGKDLKIWEDRGLQEIGEGKVAVLLLAGGQGTRLGVPYPKGMYDVELPSGKTLYQLQAERIVKLQELASKKSGKKCTIPWYIMTSEHTKGSTDNFFTEHNYFGLGKENIILFEQHTIPCLTFEGKIILQSPGKVARAPDGNGGLYAALSSSNIVQDMQKRGVEFVHVYCVDNILVKMADPVFMGFCVERSAECGAKVVEKKQPTEAVGVICVCDGKYEVVEYSEISLAVAERKDANGKLTFREGNIANHFFTVKFLDRFCRESEDELPFHLAKKKIPYVDESRQTVKPDKPNGIKLEKFVFDVFQFTDKFAVLESLREDEFSPLKNAGTGKDSPASAXQSLISLHYRQIISAGGKFVDSNGEVLPAISKDEASSIVCEISPLLSYFGENLEEVVKDRKFMASEVLHLKGPGEEENGEPQSKKTKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3R8</accession>
    <name>A0A6P8J3R8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein suppressor 2 of zeste-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574292.1">
        <property type="nucleotide sequence ID" value="XM_031718432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3R8"/>
    <dbReference type="GeneID" id="116308072"/>
    <dbReference type="KEGG" id="aten:116308072"/>
    <dbReference type="InParanoid" id="A0A6P8J3R8"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000122">
        <property type="entry name" value="polycomb group RING finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574292.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="65237" checksum="1FC8963AAFCE0014" modified="2020-12-02" version="1">MLRSMKLKSLNPHITCVLCGGYLVDATTIIECLHSFCRSCIVRYLETSFHCPVCDVEIHKTRPLLHIKPDRVLQDIVYKLVPGLCHETKNEERIIPGETEGTAEEKSDQNGCPDVIDDPVCIQLEYYGRKRFQHTEKQIFPTRFLRCSSTVTVGVLKKFLSIKFGIPPTHQPEIVRSDEILDNHITMTELSRIYGLYAKSFLDIQYIFLPNKEDDELKTEGQEAKRVKIDHLQQYRHNELQQLQRKRKGRRRKHQRKEDQQSDMQPPKRRKRRKKNGVPNKKQEPDSIEGYSLPNGVMTEDVLREKRLFYGPTTQGLVKNSNEPENNDKHHQPVQQPDHQDVNRREQEQDKETTTGNQTTRELQYEKEQQQSTPEDRLSVMEKQHGDHGCYQNRTDETNLQHVDHGCYQNRTELQTNLQHVDHGCYQNRTEQTNLQHGDHGCYQNRPEQTNLQHGDHGCYQNGTDETNLQQTQKHQSKENETRQHESVCDKAKFYQLNKHFVSAKNSTIETESNKDKETVELLKISPPPLRSRNLDNIDTSCAETFACPPQWNGIESTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J415</accession>
    <name>A0A6P8J415_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574354.1">
        <property type="nucleotide sequence ID" value="XM_031718494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J415"/>
    <dbReference type="GeneID" id="116308124"/>
    <dbReference type="KEGG" id="aten:116308124"/>
    <dbReference type="InParanoid" id="A0A6P8J415"/>
    <dbReference type="OrthoDB" id="115435at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="114"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574354.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44335" checksum="1A10756731FCF8A6" modified="2020-12-02" version="1">MKGNRVIIPTGMRPGILDRLHDAHQGLTSTLQRARRTVYWPKLQDVITEMIQKCDECPRYGDKKTRPSERQITATRPMEILGMDLLDFQGQHALVTVAYFSGFLTCGILNNETTDAVIKVLNNIFRNFRHFCEQLDIGHITSSQHYHQSNGRAERAVATVKQMLKKSANEIDITKALTTYLDTPLSDTLPSPAELFHNRRINTSLSRTIPPIWFIDGNSDEWKPGYIESKDSIQTHTGSSMTRQRPQTSIPLQFSGNLSDVTPIELMPTSATPDHEMPESVLPSTDTPNTLAAPTPTKQGKTATPWKPKTFGGEGTRLKITDSTPVLTKLCSGHEIKPHRDPEFVYGFVKHCTIVTSLRSLKSLRHVSIQYISILVLETSSRGDLLPVPTHGLRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4V5</accession>
    <name>A0A6P8J4V5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Interferon-induced protein 44-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575091.1">
        <property type="nucleotide sequence ID" value="XM_031719231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4V5"/>
    <dbReference type="GeneID" id="116308749"/>
    <dbReference type="KEGG" id="aten:116308749"/>
    <dbReference type="InParanoid" id="A0A6P8J4V5"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575091.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34312" checksum="0598451A8C2EE74E" modified="2020-12-02" version="1">MGNWLWNSPPQPQQPQQVLTDTPWRKTKEWSPEVKRELRDHISSLAPQTRGQLDVPFFNIALTGQIGGGKSSFFNSVNSIYHERIISGKSEVGITATSLTKDFRVYEINPHPDQPDSNPLPWRICDTPGLNYSLDTDCDVTNILKTVDGHVPDRFKFPSQEVLQDDLGLKKPELKDRAHCVAVVIDGSTFDQMEENMKRKLKNLRKGLITRNIPTYILITHIDEACVEVSKDVSKVYRSIAIRDLVHKIGRLLHGLPENQIFPIMNYKKQVDLEDDIDILLLYALRQMLYSAQGHLENKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5I2</accession>
    <name>A0A6P8J5I2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116308621</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116308621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574952.1">
        <property type="nucleotide sequence ID" value="XM_031719092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5I2"/>
    <dbReference type="GeneID" id="116308621"/>
    <dbReference type="KEGG" id="aten:116308621"/>
    <dbReference type="InParanoid" id="A0A6P8J5I2"/>
    <dbReference type="OrthoDB" id="10047910at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF17">
        <property type="entry name" value="PROTEIN EXTRA-MACROCHAETAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574952.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="16130" checksum="E98882BB11DA5A5B" modified="2020-12-02" version="1">MPSRENPQSNDMEDHRTRILKDCVRTYNRNIKMMEYARLRSLVPSVACKSRVSKIQVIEEAIKYIAHLQQALRTQPQNADQGEANTRNTEPESPEKRRTSLRQKRQRIASYMIKTQRHMPRTRPKFSNSSAKKDFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5L1</accession>
    <name>A0A6P8J5L1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116308654</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574987.1">
        <property type="nucleotide sequence ID" value="XM_031719127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5L1"/>
    <dbReference type="GeneID" id="116308654"/>
    <dbReference type="KEGG" id="aten:116308654"/>
    <dbReference type="InParanoid" id="A0A6P8J5L1"/>
    <dbReference type="OrthoDB" id="5970735at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00045">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="3">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="709"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031574987.1"/>
        </source>
    </evidence>
    <sequence length="838" mass="95092" checksum="ED5423E09D8BC071" modified="2020-12-02" version="1">MPVRTPENRFRALLLDLADHLTPEEFEKLKFLCKDDIPGVNNKTTTRDLFEKLIEAGKLSLENTGYLEKLLTNIHRVDLIKNELQKFIDNNCNETDGVNESPGAQTCGLRVKQTNFIGRNDLVERIAKVYVTGQKPMVAVVAPPGFGKTCVATHVGHAMKDKGFRVIYVSLQKMQSCHLMCCDILRAIDTKIPSSDDVVQLTKSQLKLLEVQTLLILDNAEDIQNSSHSCDFESFIEFLGSHAKKLKIFLGTRKSMYTRYFEHESINLLPLDDEASLKLLLALADGTSLNIHEAKKLAIQCAGVPLLIKIAAGLVKNGYNPIKLANNLQKKPYDVLNLKENEQIKFLTNSIQVFLDSLSREKLVCLVQLSCFPAQFTEDIANEILFKNEVKCSGMLSSLHASALVQLDGKNYSLHPLIQTFCREEQERMKCKKEGEKATEKFSNYYFDELEKLHCQFVSKDGCQKALKQFCCSKMNLLQALENALRCDDKEMKKRCIDAFNASINLLGKILLPSCCLSVYEQLYNEAERIKDKKRMSECLVSRGFRFMCEVNHGEFSQDAFDAFETALSLWKKNLFKRMQSTEAYAHCISKLGLCYTFKGDTEQGKKLINDAIPIRSRLGNKVLLAASYCDKAIAVRFCNKHTQAIEIFETRCLPVYKEHLGDHPWVASLLSYMSKCHQDLGCLEKAIECNKQSLEIREKLLGDHQDTARSYVRRGELFVEQENMKDALKAYRKAASIQETVLGIHEETKTSYQAIEDILHKLNMDEERQKYRKRAETYSTEIKNTRTLNKQISEDIKRRANSLSVFPGLNMITRVAVVVGLVAVIISCVLLCNGVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J602</accession>
    <name>A0A6P8J602_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Telomeric repeat-binding factor 2-interacting protein 1</fullName>
            <shortName evidence="10">TERF2-interacting telomeric protein 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Repressor/activator protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116308809</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575164.1">
        <property type="nucleotide sequence ID" value="XM_031719304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J602"/>
    <dbReference type="FunCoup" id="A0A6P8J602">
        <property type="interactions" value="1698"/>
    </dbReference>
    <dbReference type="GeneID" id="116308809"/>
    <dbReference type="KEGG" id="aten:116308809"/>
    <dbReference type="InParanoid" id="A0A6P8J602"/>
    <dbReference type="OrthoDB" id="5981503at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000246">
        <property type="entry name" value="Telomeric repeat-binding factor 2-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="3 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="11">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="12">
        <location>
            <begin position="418"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031575164.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55016" checksum="C912DD5E3391C968" modified="2020-12-02" version="1">MAAKNASNSFLFTHEDGSPMVFVIIPGDTKKRLRPVVENGGGVITSKETPGAIRLVEPNYKTGKQLVSSDFVFDSYKRGTLCNIEDYRIETKPDIIASPGKIHITVKTEAAQNGRMKYSPEEDQAILDYIRKFEGQDVKLSGNKIWQEMENKKVTCRRWQSMRSRYLSFLRQSTCSTSHKGKLEFIESKNISKSQITIDDNSAENALPNKKIKTSCHFFQKDVTVNEKRKDKENVRASLPKEQKTCFESNCDEIIQQTYKTSSIQKNKVVNTLDKSESQDVEAEDLHVTCTCTSSFVDKSSNACCNKRLQTDDTGFCATCRKNNSPKRNSIEGTINSCNSEIRKLKAQPKDISSRKVESGKEHFDVPQYDMLCNHDNENSTDDCSPVLRCHQLFENFKQIEMISQKSPCKTQTPTPVQVLHALYVSCGCLKCASHYLQTGLLLNGQEIWKREEDLAISSGDAVAIKKIVDKRGQKAVDSRKQFLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JD63</accession>
    <name>A0A6P8JD63_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Low-density lipoprotein receptor-related protein 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116309104</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575518.1">
        <property type="nucleotide sequence ID" value="XM_031719658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JD63"/>
    <dbReference type="GeneID" id="116309104"/>
    <dbReference type="KEGG" id="aten:116309104"/>
    <dbReference type="InParanoid" id="A0A6P8JD63"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000008">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000030">
        <property type="entry name" value="Sortilin related receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF12">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028395266" evidence="21">
        <location>
            <begin position="25"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="486"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="528"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="571"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="617"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="755"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031575518.1"/>
        </source>
    </evidence>
    <sequence length="904" mass="99636" checksum="EDA32F904A6959CE" modified="2020-12-02" version="1">MKVLGVILAMIFLLNVYTSSTTNAAESPSAFHCGGDQFQCVANQTCIVRRWRCDGEPDCDDGSDEKDCPPRTCHSDQFRCTNGKCIQKSWVCDREDDCKDGTASDEQNCGNITCGPNEFACANKNCVVALWKCDKHDDCGDNSDEDPKICNTHVHTCSPSQFTCSSGQCISSRWVCDGDNDCPDGSDENPSQCSAKTCPPNEYTCQGLSKKCIRSSWRCDGDRDCPDGDDETSCPPVSLKTCASGMFKCKNKECILGHWRCDGEDDCSDGSDELNCHISNCTSSQFACSSGRIKCIESRKRCDGRRDCSDGSDEQRCAPSVPCTPDQFECGLTSVCIPKDQVCDGNNDCPNAEDEPMRCNINECLDSNGHCDHFCHDLNIGYNCSCREGYQLQSNGRVCEDINECLEYGKCSHLCENTKGSHKCVCQPGHLLEPDRRTCRATGPEPSLMYSSVTSVRKMTLDGSSAYSVITNRKGVVGLDLDFKTGKIFWTDTKAKKIHRANFDGTAIEDIVSNVSVPDAIAVDWIGRKMYWTDGTLNFIEVAELDGSNRMVLYSEGLDDPRAIAVDPFRKYVYWSDWGYNARIERASMDGAASSRQVLVNTNIGWVNGLTIDYNIDRVFWVDAKVKTIESMSLDGSDRRLVARIPSQHPFAVTVFGDYLYYTDWTRRARSIRKVNKFTGGEKKIVINLLWAHMDIKAVHPTRQPNGSNPCAPNNGGCSHLCLLSSVTTTYTCKCPTGMNMSSNGKTCIGKPFTGQPTASPTTLTTTQTTTQTTTPQSTTKSNNIGKPTKESVKPTQKGTGNATEAVPTTQENAIAAKRAANDEKEGANLKVIIPIVVVVSLIIVLVIVAAYVWRTRYSNYKASISYYKEYKDMASKPLEEDFDDNETTKVFDDGGPRCKVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JF41</accession>
    <name>A0A6P8JF41_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308656</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574990.1">
        <property type="nucleotide sequence ID" value="XM_031719130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JF41"/>
    <dbReference type="GeneID" id="116308656"/>
    <dbReference type="KEGG" id="aten:116308656"/>
    <dbReference type="InParanoid" id="A0A6P8JF41"/>
    <dbReference type="OrthoDB" id="100767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00045">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="DED" evidence="2">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="701"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574990.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="88351" checksum="AEA323047A5FE096" modified="2020-12-02" version="1">MDSLIDPFRALLLSIANDCTDEDFTNMKFLCSGCLPEGRLEDISSPRELFIELIHDCIISKDEKQPLASLLFNIGRQDLRNRLLGKESPTLAGAFQHWGGLPMKIPNFVDRKDECQEVLSKLRRGTCKVVMIIGPPGFGKSSVAIQVGHDLCLHGISVYYISLRSCTSMFCMVNYLLGALRIVASEKPIKQAMHCLCNLTTDTVIILDNAEDMLLPPIKDEFCGYIENVAQTAQFVRILVTSRMSMTFLNVDSHVLRLDALERKDAQKLLKTFRSNISDDDSEVLADLCGGVPLVLRTTASLLANEGTVHPKALISEFQRSPVSTLKSFDLLTLSHDHQIFYCLNICFERLSHELQLALISLCVFPTSFTLHDAQFILKEHSEFYLELHLQELINNSLLQFDPVMKEYTMHGVIQAFCKDKTTTKASKYQWKYEFAKKEFNCHYLELLPQLQEQFISKKALAAVENFLAKRRHIRQAMLDAVNDPELEKTCIDTANAVAPFLTKVLRKEKFLTIFQVYTKICKDKEDEKRYSDCLTSEAYCILSHCACHLPCPTAVSRFKEADAIQTKLEDESSTIRSHCLIKLGRCVAHYGDLDKGITLIKRGIGIREKMNDPVQLAVAYKDLAASYSFHKQHHTANRLRVEKVLPVYKQHLGDHAYTATLMDDMGMSCMALSNYDCANTYIKEAVRMRVKALGDHQETARSYHDYGTVLKAQGRYDEALVAIREALRIQENILGAHHETIRSHQEIANVLKLLGRNEEACNETKLAESKKKDLQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0X6</accession>
    <name>A0A6P8H0X6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Disintegrin and metalloproteinase domain-containing protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116286608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549021.1">
        <property type="nucleotide sequence ID" value="XM_031693161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0X6"/>
    <dbReference type="GeneID" id="116286608"/>
    <dbReference type="KEGG" id="aten:116286608"/>
    <dbReference type="InParanoid" id="A0A6P8H0X6"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="5">
        <location>
            <begin position="110"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="4">
        <location>
            <begin position="294"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031549021.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43452" checksum="EA7DC224376E85E1" modified="2020-12-02" version="1">MFKVSLLPLQYYYTSQSYFSLGDHEASASFNVNNWVLDTKRNNELAPKTVTVRRFLADNSEVLHAVSPDNCHYQGSIHGVPDSTVVLNTCNGLRGIIDDGKDTFHIEPHDNQKYQGYQNDTKTVIDKVLTLCNAVDAIYQRINVRIVITAIEIWTNGDRIERRTSGGAELGTFQAYRQKELIGKIPHDNGQFLSNHGWGRVIGMAYVGTMCKRLSSAINKWSFGSVIGPYVTLAHEMGHNFGYGHDSEYCKCLTPKGCFMGGHKTRVPGFSNCSLESMKRINDQCLYNKPMVLRPQCGNGIQEGDEECDCGTPEMCKIKDPCCQPHACKLKPSAVCSDLHHFCCKDCQYKRQGTLCRPAETDCDVPEYCPGNARDCPANNYIQNGTPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1B4</accession>
    <name>A0A6P8H1B4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116286741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031549181.1">
        <property type="nucleotide sequence ID" value="XM_031693321.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H1B4">
        <property type="interactions" value="2557"/>
    </dbReference>
    <dbReference type="GeneID" id="116286741"/>
    <dbReference type="KEGG" id="aten:116286741"/>
    <dbReference type="InParanoid" id="A0A6P8H1B4"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000003">
        <property type="entry name" value="OTU domain-containing protein 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549181.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34247" checksum="0DDC0CE7D0486720" modified="2020-12-02" version="1">MADEVEENVTEHLEIIKARHKKENKELLAKIQVLKHSIPKGDKKKKKAVALDIAKLEAEQEERHXKEVEELQIQTKTSNSESDISSRLQDTTISTEPEEIGNKSSRAEKRRAKKAAKEQEREQRIAEAELENVNCARNIEAEKMKNILQERNLQILEITPDGHCLYNAVADQLRRRKLESDYQQLRKQVSEYMLTHSSDFLPFLVHPQTGESFTQDEFTNYCQDIASTSAWGGHLELQALSHILRMPIEVVQADASIIRIGEEFDTNPLLLSYHHHAYGLGEHYNSLIPVTSEEQQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H302</accession>
    <name>A0A6P8H302_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116288168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550779.1">
        <property type="nucleotide sequence ID" value="XM_031694919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H302"/>
    <dbReference type="FunCoup" id="A0A6P8H302">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="GeneID" id="116288168"/>
    <dbReference type="KEGG" id="aten:116288168"/>
    <dbReference type="InParanoid" id="A0A6P8H302"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="8">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031550779.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57480" checksum="27F17967975F7D7C" modified="2020-12-02" version="1">MALRQSFRTKHVSKFKHVFGKPNKKEFCYEGIRISKNAWESNFCAVNPKFLAVVLEAQGGGPFIVLPLERYGRIPLTYPKVCGHKGPVLDIQWNPFDDNTLASASEDCTIKIWYIPDGGLNEDLKDYVGQLCGHERKVGIVRWHPCASNIIASAGFDNVVIIWDVEREAAVLILKGHPDTIFSLSFNWNGSLIATTCKDKKIRVIDPREGKLIASDFGHRGPKGSQITFVGNSNYLFTSGFSKMNQREVALWDLANGLHKPLTIEPVDESSGLLMVYYDPDTRMVYLAGKGDGNIRYYEILEEEPYLVLLNEYRSSSPQRGFGVMPKRALDVAHCEVARFFKLHNNGFIEPIPMIVPRRDSGTIHFDLFPPTLSNRPAMSGDEWLRGMNKGPLLDDLLAGITGDNGMSRESYEAVTPIKARTEKRKENPIMQTQNDVAYSEPHLVNGNKGETTSRKGDYMSWDLDTLRVAYADLFEEVHSLKMQLKVRDAKIDKLERDHKYYSDKFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3K9</accession>
    <name>A0A6P8H3K9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">T-box transcription factor TBX20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116287496</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550040.1">
        <property type="nucleotide sequence ID" value="XM_031694180.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550041.1">
        <property type="nucleotide sequence ID" value="XM_031694181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3K9"/>
    <dbReference type="GeneID" id="116287496"/>
    <dbReference type="KEGG" id="aten:116287496"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000008">
        <property type="entry name" value="T-box transcription factor TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF190">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="75"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031550041.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41804" checksum="A4DD8B50B97EB4E4" modified="2020-12-02" version="1">MSSVTAKRTLLSTKAKAFSIASLVEQGNEAECGQVDDNMVKEPSEEGAPCTSSSKKRKLLNYEAVEEKRKPQAILEGRELWECFYRLGTEMIITKSGRRMFPPLRVSFTGLDPNQTYAVVLDVVPLDNKRHRYSYTDSAWFVAGEADPTPPRRVYTHPESPFTGEELARQVLSFERVKLTNNPKDSNGNIILNSMHKYQPRVHLIKNPSEDEQDLDKSDSFIFPETAFMAVTAYQNHLITRLKIYSNPFAKGFRDTTRLLPSFEEDGYVIQSDDFSRCCDMRESMCCHLSGQLSCYPHDTRDTTDHRIFSSQDTRWACTDDCCHGAEYPWRPAHGYARSVDFYSSDGPPCALMNCSSALAEERLRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H485</accession>
    <name>A0A6P8H485_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Beta-2 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16 17" type="primary">LOC116287713</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550255.1">
        <property type="nucleotide sequence ID" value="XM_031694395.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_031694396.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550257.1">
        <property type="nucleotide sequence ID" value="XM_031694397.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550258.1">
        <property type="nucleotide sequence ID" value="XM_031694398.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550259.1">
        <property type="nucleotide sequence ID" value="XM_031694399.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550261.1">
        <property type="nucleotide sequence ID" value="XM_031694401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287713"/>
    <dbReference type="KEGG" id="aten:116287713"/>
    <dbReference type="OrthoDB" id="5975661at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="315"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031550255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031550257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031550259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031550261.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43549" checksum="1992D55DB296A67B" modified="2020-12-02" version="1">MLNQTGHNLTHKATPSYEDEKLFDIPATWIIILTIIMVIAQISTLIGNAIVIIVFATSDVLKSSVNNHFLVSLAVADLLVGILVMPCAIDALRVQTWRCGSYKYFNAFGNFCFCISSIMHLMILSVDKYFAIARPLKYPQVITQGRAYIVCIVLWVYSGFWALLPLIGVSSYECFIPYIGFCASKDWSMKGLNFAFAISVVSGTYGXALIVMFVIYFKIARIIQQQTKRIGIVVTDRNDTQDAIQNTQTSKPNLIKRYRGVFTLITLIITYLICWSPFCVMLFIEIGMARKMEGAASMIGMLVGFINSCCNPIIYWAXYKRFRRAVSRLLRKGLLFLPVSMDSNNVHSLSHTQGENTGRSIQVNRIVADKPTITDVKYTINAIYINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4K1</accession>
    <name>A0A6P8H4K1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thromboxane-A synthase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550473.1">
        <property type="nucleotide sequence ID" value="XM_031694613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287907"/>
    <dbReference type="KEGG" id="aten:116287907"/>
    <dbReference type="InParanoid" id="A0A6P8H4K1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550473.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12609" checksum="9B2855C70F82DBE5" modified="2020-12-02" version="1">MQVVFPIYRLHHDPEAWPEPENFDPERFRGPAKXSRHPFQFLPFGEGPRNCIGKRFAQLEVKITLVNILTKYRFVRCPETQVPLKMIPGFTLIPKDGVFLRIESCTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H672</accession>
    <name>A0A6P8H672_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neural cell adhesion molecule 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031550981.1">
        <property type="nucleotide sequence ID" value="XM_031695121.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H672">
        <property type="interactions" value="1300"/>
    </dbReference>
    <dbReference type="GeneID" id="116288353"/>
    <dbReference type="KEGG" id="aten:116288353"/>
    <dbReference type="InParanoid" id="A0A6P8H672"/>
    <dbReference type="OrthoDB" id="5981765at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="114"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="204"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="298"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="388"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550981.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49555" checksum="C47DF14715A94D6A" modified="2020-12-02" version="1">MIRNVGQDAFFMWNSTNGHRIFEARWGLETDGVVKPQFIYVDRSHNVVLSTDLERNALRYKGRVHWVGNINSGQVWFKLTNVTLNDTNQYVAGIVEEGKPNTIYSAQLTTAATPQFVKRPPLSKGIEEGQDLVIKCTAIGPPTPKITWVQXESQVSMSTGMGSAILRIANIRRXQXGTYECQARNNPNKRLVTAQTVVTVYFKPTVNESYSTSKSKSWNGNSIHLRCFATGLPSPRISWYKPTNQQITTGVIIVPGGSEVTVLTATDQGDYGQYKCRATNILGSDEHVINVTKLISPGPVSLTITDVEASSINVTWYKPADDGGLDVTGYLVEVSTKPPVITVNTQTVITGLKANKLYAVKVYAKNIVGYGVESSKIIRTQKIGKPSAPELVIALLERSPEFKLSVXLRWEEPDDNGGNISRYTIYVKEVEKKAEWTKYDNVIDSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7C8</accession>
    <name>A0A6P8H7C8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116288552</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551213.1">
        <property type="nucleotide sequence ID" value="XM_031695353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288552"/>
    <dbReference type="KEGG" id="aten:116288552"/>
    <dbReference type="InParanoid" id="A0A6P8H7C8"/>
    <dbReference type="OrthoDB" id="6369483at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF144">
        <property type="entry name" value="SPINDLE AND KINETOCHORE ASSOCIATED COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551213.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41434" checksum="10B7C81AEA7D37F1" modified="2020-12-02" version="1">MVLCIIVGCSARSGRDKDFSFFRVPCVVTNRGELEEELSRERRTRWISAISRDNLTEKILDSQRVCSRHFVSGKAASLWDRHNVDWVPTLNLGHSKTASNALSAEATKARADRANERRKRSLEWQAMEVAEKVKRINEPGLCVSNIDFETVDLTESVEGIEQDGNEAASDSPANCTDDILASAAQSLKLVDKASQTEEFEYLFEQRRPKCFSERYFLESDDCDERVRFYTGLPCFSILKKTFHHVSPHVTYKSKRLSQFQEFVLVLIRLRLNVFMQDLAYRFEVSRRTVNRIFHAWMIIMDERLSPLIYWPDREALQSTMPQCERGQHAXLIAMKYSLTSQAITWPEHKHSLTTSTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8D3</accession>
    <name>A0A6P8H8D3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Paraspeckle component 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116289899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552704.1">
        <property type="nucleotide sequence ID" value="XM_031696844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8D3"/>
    <dbReference type="FunCoup" id="A0A6P8H8D3">
        <property type="interactions" value="3407"/>
    </dbReference>
    <dbReference type="GeneID" id="116289899"/>
    <dbReference type="KEGG" id="aten:116289899"/>
    <dbReference type="InParanoid" id="A0A6P8H8D3"/>
    <dbReference type="OrthoDB" id="10067824at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12931">
        <property type="entry name" value="eNOPS_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12332">
        <property type="entry name" value="RRM1_p54nrb_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000043">
        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012975">
        <property type="entry name" value="NOPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08075">
        <property type="entry name" value="NOPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="76"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="149"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552704.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="57551" checksum="291F7BC487895712" modified="2020-12-02" version="1">MPENQRRSHSPRRSSSSGTKTKREKSSNESSSNTKDGASNRNRDSNSFKDNYRQERNRTVSYSSGLKKERKFTGRCRLFVGNLVDCDEQEMKEMFSKYGEVAEVFVNKEKGFGFIRLDTRLNAEAAKAGMDMTQRKGRTVRVRFATHAAAIQVHEFGSYVTNEVLEQAFSQFGDVERAVVVCDDRGRSKNYGIVEFARKSSANNAMHKVKDNLFLLGRTPKPITVKAYEQEDEEDGLPEKNLERQPGYQKEREVPPHFATPGTFEYEWAQRWKSLEEMEQSQRETLDKQFKEAREKLENEMQQAIKDHEAMLMRQADMQRRQEEMRRHEEMQHREEMRRQEMMQKEVEMMRRREEERRYQEELRMQEEARHREEMMYRQRQDDFMRRQEEMMRNDMRPMPFPPRGMPPKGPRGDWGPGPMGPMGMGPGPGMGPPPHMHGPRGPPMGPGPMPPMRPGRFDPEMDRKRERADRDRLAARSPRDHDKRRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8R5</accession>
    <name>A0A6P8H8R5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase family member 11-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase family member 11-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116289989</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552813.1">
        <property type="nucleotide sequence ID" value="XM_031696953.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552814.1">
        <property type="nucleotide sequence ID" value="XM_031696954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289989"/>
    <dbReference type="KEGG" id="aten:116289989"/>
    <dbReference type="OrthoDB" id="5811916at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053998">
        <property type="entry name" value="ACDH-11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22217">
        <property type="entry name" value="ACDH-11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="231"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="345"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase 11-like C-terminal" evidence="8">
        <location>
            <begin position="510"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031552814.1"/>
        </source>
    </evidence>
    <sequence length="635" mass="71099" checksum="B7FA75CF667661EA" modified="2020-12-02" version="1">MKMLTSKLLDKPFRLLKFANVQYFIRGIRLSSSAISMKEKSKTDQAENMDVPLPFSXSRRGCFFQDPPELDNQFTRDPHLRSCVKRILPRQVLEEILPDLEQFGKRVSTDIQSMGMDCESRPPTLEHFDGWGHRIDRINTCEGWKQLHDVSAEEGLVAIGYERKYEQWSRIYQTIKLYLFSSSSGLYSCPLAMTDGAAKTLEICNPSGEMFKQAFNRLTSRNPSQFWTSGQWMTERQGGSDVANGTETIAIPQSDGTYTLHGYKWFSSATDADITLTLARIQQPDGSTIPGSKGLTMFYLETRDSDGHLNNIEVQRLKNKLGTRQLPTAELLLDGTVAHKIAAEGQGVSVIASNMLTVSRIHTSIMAVSAMRRILSLAQDYCLKRSVFGKLLVQHELHMQTLARLEVEVRGAVLLVMEVSRLLGLEDCKMANEKELHLLRLLTPITKLYTAKQAMMVTSEGLESFGGQGYIEDTGLPGIMRDAQVLPIWEGTTNVLSLDVLRSINKTQGQVLKALHSSVHSKLSLAKDKPALQLAHDAIHSAIDSLMSPKYVETLTRPVIARDLAYSLARIYIGALLIEHACWEEANETDIEAAKRWCLQDMTPVITNLNQNLYDNTSTSLDIALVMDRQAPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA25</accession>
    <name>A0A6P8HA25_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15 16" type="primary">LOC116289608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031552416.1">
        <property type="nucleotide sequence ID" value="XM_031696556.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552417.1">
        <property type="nucleotide sequence ID" value="XM_031696557.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552418.1">
        <property type="nucleotide sequence ID" value="XM_031696558.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289608"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000097">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="117"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="14">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031552416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031552418.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="44330" checksum="A13F1A2F6789BF71" modified="2020-12-02" version="1">MLSMERLNVKQLCFCAVLVFVLVHGAFSKAVLGTVATRIAPFRANDADRSDAVQLXQTDIFATXLKANAKNSHSAHGQVNAEALFQGDILMTEELRLALNTSGTDTLSLPLRVTAGRAVNGHDQNRWPPIGNGLVXVPYVIEQSCVADXSVIQQALSHWAEKVPCIAFVPRTAQVHYLSFFSGQGCFSWVGRKGGKQRISIGPGCAVMGVIAHEIGHALGFWHEQSRPDRDRYVKILWNNIRSDNLDNFKMIDNSDTNDLGVEYDLASLMHYGPKAFSKSPSLNTIESLDGSTTFGQRNGLSDKDVEQARLLYCNGSSVCQHKDHNNNCPWWAEAGYCHSSSIYYPFMNKNCKRSCYCSYVCEDKTANCPSSASSGSLCTDQRFEKYMSVYCKRSCNLCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA97</accession>
    <name>A0A6P8HA97_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein phosphatase 1E</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Ca(2+)/calmodulin-dependent protein kinase phosphatase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">CaMKP-nucleus</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Partner of PIX 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Partner of PIX-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC116290466</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 28">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 28">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031553359.1">
        <property type="nucleotide sequence ID" value="XM_031697499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HA97"/>
    <dbReference type="FunCoup" id="A0A6P8HA97">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="GeneID" id="116290466"/>
    <dbReference type="KEGG" id="aten:116290466"/>
    <dbReference type="InParanoid" id="A0A6P8HA97"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000021">
        <property type="entry name" value="Protein phosphatase, Mg2+/Mn2+-dependent, 1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF818">
        <property type="entry name" value="SD03870P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 23" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="25">
        <location>
            <begin position="132"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="395"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="500"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00079435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_031553359.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="61734" checksum="0110927B9685E3E1" modified="2020-12-02" version="1">MGVEFTEEEKQKAADFLSKFALEHASPEEKDSLPFRVDAPHSIGSEEIHGYVIEWALEYLRKCNCPDDLAATITHHATQELLEADLTCYKLQNNKGLDVDKLVKATFNKVQEICVDWSHAPPKMFKSERSYQSCVHAIKNTRRKMEDKHIIMPYFSTLFGLPKEFPSLAFFAVYDGHGGVDAANYASANLHVFLSMNENLHTDPGLALYETFMMTDECFGLKARTEGLKSGCTAVTVLISNDTLHVAWLGDSQAVLSKGGEAVILMEPHKPDQKDEKDRIEALGGCVVYFGAWRVNGNLSVSRAIGDVEHKPYISGEPCLSEFTLEGDEEFVVLACDGLWDTVGREEVVKLVNAHVAEGNDRGTAAKLLVDTAKRAGSSDNISVIVVFLDAHSKTNSSKDISNPVIVRNHSQTPSHNGTTKPSNSKVNNETANSNQEQNDIEKLGVSEVVDQLVPIIAKVKISTETTETITTPTMTCKITCKEDKSYNNSGQLAQITKKLSLEQQTRSAESSPKQDKKTKTKSITPVGKASPKTKPKASSHLDVDQKASLRRRSAPGAFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDA1</accession>
    <name>A0A6P8HDA1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lateral signaling target protein 2 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553646.1">
        <property type="nucleotide sequence ID" value="XM_031697786.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290682"/>
    <dbReference type="KEGG" id="aten:116290682"/>
    <dbReference type="InParanoid" id="A0A6P8HDA1"/>
    <dbReference type="OrthoDB" id="20035at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="525"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553646.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="65410" checksum="44A6E060A17430DC" modified="2020-12-02" version="1">MDXSVTSITTEEPADQQKKCSDCHKSFKSCQCKACSKCGSLFNKYWGTNLAKGRSHCRVCFAAVCLTCHVVLNNTFKICTRCHIRQKEEELSTQKALSAIDKAKSGRSDSGTSQLSSDYVFINVAAAGSMTSDQKKEALFEASKKGDHYALVTLLNANADVNAKDASRNTPLFYAAEGGFLPCVALLMERGANITLVNDACWTPLHAVAWKGSTDDHVECAELLIQMGADVFALTSTSETAADLAERCGGKLELVQLLRAAEVDVAVKKLQKRLRNVSSKDVLIKLYIEALIRHITKDLDQSWLEEDNISQSSSSNSSPILLRACNKIEENNRGKLTPEKLLKNSCKTASLDRRSNVGKELKFDNKASTLSRAFGSSQNLTNIPQADVEPIIRTDYTTFPPSNTASLEEKLRQSQSETEDAEKRCKRLMQAMAVAAEDHEKEVSQLKQEMEQLKEKNEITLKRVEATYVNKISMIRQEAETSVHEANEQVKQVMKDRGDLLHLQDTFRLTWVPDELVAQCSSPKCRAPFSQTRRRHHCRCCGRVFCKVCTDQSCKLTAFGYHQPVRVCNPCYALVEDMFLNEQEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDD6</accession>
    <name>A0A6P8HDD6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">C-C chemokine receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116291386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554414.1">
        <property type="nucleotide sequence ID" value="XM_031698554.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554415.1">
        <property type="nucleotide sequence ID" value="XM_031698555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDD6"/>
    <dbReference type="GeneID" id="116291386"/>
    <dbReference type="KEGG" id="aten:116291386"/>
    <dbReference type="OrthoDB" id="5965524at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000368">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031554414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554415.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38823" checksum="841EECF992BF80DB" modified="2020-12-02" version="1">MMPSAEIALLTLFSTMATIGLVGNLLVCFIIQRNRPVKRPINYLFLNLAVSDAIVLLFLSSKYVLIHTYEHPTGNIGDFLCKFLTGGSLAWTGAISSVCTMICISFERFYIVLKPCYYLKVFKVSNIKVALVFSWVFAVVFNIPLFIFGNFDADKEHCTEAWPPGGFSKFYALTWLAVVAVIPAVVVFVVYSQIIYILWIKKNTTTTAITRTAMHKARRKVTKVVYIISLIYCVSWFPPLIINVIAVFAPNRHIGDVTYEAAVFLIVINSSVNPLVYTFQSARFRQHLRHLFCRRKAKNSVCPQGGETNQAAWIPPLSNNRCNGGQVKELQVASQDLLFLWLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDD9</accession>
    <name>A0A6P8HDD9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116288083 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116288083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550677.1">
        <property type="nucleotide sequence ID" value="XM_031694817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDD9"/>
    <dbReference type="GeneID" id="116288083"/>
    <dbReference type="KEGG" id="aten:116288083"/>
    <dbReference type="InParanoid" id="A0A6P8HDD9"/>
    <dbReference type="OrthoDB" id="5989450at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031550677.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="62502" checksum="FFD68459122FF6AE" modified="2020-12-02" version="1">MILFRKKVFHVGITFAVTLITNLIIFASSRMNETNITTTATPDNSSTTTSPSKLPQPPLARSCIDKKVLNVCWLKTPPYIFDRPSNKSIVEGILSDAILEGFTKCECQVNLNYSIQVYEEEDLINCSKNKDIDIVLPFPQRGIRNNNWFFKVVDSAAIYLLLNRKKIESQAKANIIYEFSQVWTLAVLTILLAAIFGIVVWSLDAAWNRKQFPPTFCPGALEGVWWSFVTLTTVGYGDKTPKFPLARIFAILWMFVGMCMVSLLTATLTKTLTTGLVENRREFHGLKIGVLKSSHTYDEAVKKGAKTQKYLDLKSMYTALNNDEIQGILVDIFVATYVRNNLNVFGFQDNIFVAQSYDIQYSIGVYFGYGMAMYEDSKPFSILTDCLRSMFENANRRIDVFSIVEKYIQSQEIVEKSKVYDEFKIEINLFSPTSDIFLMGLRTLCIILGILVFFGIIWEIVRCRWRKTIFLPKTHAESIAMSGHQKMTAENINKLVKKLDEVERALGKVMEFREIYEHCKIDIQRYDSGIANGNPHGISGTPNSGYSNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDV5</accession>
    <name>A0A6P8HDV5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031550822.1">
        <property type="nucleotide sequence ID" value="XM_031694962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDV5"/>
    <dbReference type="GeneID" id="116288204"/>
    <dbReference type="KEGG" id="aten:116288204"/>
    <dbReference type="InParanoid" id="A0A6P8HDV5"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="96"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="546"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550822.1"/>
        </source>
    </evidence>
    <sequence length="750" mass="85847" checksum="FB6785A665382AA8" modified="2020-12-02" version="1">MADLKYELTKQEDNVGNDVMVSSSEKQPRLKPKQKTCAIIVVGVLVFIILLLLIGIIVIGVALHKARQKQPSPCLTLDCINAVSDVARSVDNSVDPCNDFYQYACGKWSQNNPTHESKSSWDPISQRAFQNQEKIKHLIVGKETRGRYYQKEAFRKIFDLYDSCVDDNTMSELGGKPLKDLMDSLSSSPGLNSSWNEGSWDFNSVILEINRNYTPFVFFKLWVQPLEANSSVNGIFMQSGGMSLASSRYNSNHTRNVEIKNAYKAHMMRLFKLLGLNQNQSQEMMESAFSVETKIAELSRNVPDALKEEVLTIKEMDKDEEKTKINWLEFFTKLFEDTDFKPTESTQIALQSRTFFKSLNRYLYNASKSDLANYMMWRLINHYSSILSKPFRQSLPTFYKVFRGTVPEVPRWETCLMEVKSYFGMAIGRMFVEEVFRNGSKAEVTEMVENIKEVFIQDFDQVDWMDSKTRAVAKEKAKAMDEHVGYPEFIMDDSKLADLYKKMDVRNDTYFRNYLSIDKIDKKKTFEKMGNPVNKESWEMSPTTVNALYKSTSNSIDIPAGILQKPFFSETYTNSLNFGGIGSIIGHEMTHGFDNLGRTYNQKGNLKKWWSNSSIENFERLAKCFVDQYSNFTYEGTNLNGETVLGEVIADNGGVEISFKAYKLWVKAHGQEPMLPGINLSHEQMFFLSYAQIFCASYSKGSAARMISYARHPINPLRVKGVMVNSHEFSRAYNCPVGSPMNPAKKCKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEW0</accession>
    <name>A0A6P8HEW0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Alpha-1A adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17 18 19 20 21" type="primary">LOC116290984</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554001.1">
        <property type="nucleotide sequence ID" value="XM_031698141.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554060.1">
        <property type="nucleotide sequence ID" value="XM_031698200.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554133.1">
        <property type="nucleotide sequence ID" value="XM_031698273.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554209.1">
        <property type="nucleotide sequence ID" value="XM_031698349.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554286.1">
        <property type="nucleotide sequence ID" value="XM_031698426.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554363.1">
        <property type="nucleotide sequence ID" value="XM_031698503.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554428.1">
        <property type="nucleotide sequence ID" value="XM_031698568.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554496.1">
        <property type="nucleotide sequence ID" value="XM_031698636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290984"/>
    <dbReference type="KEGG" id="aten:116290984"/>
    <dbReference type="OrthoDB" id="6358729at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="72"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031554001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031554060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031554133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031554209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031554286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031554363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031554428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031554496.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41427" checksum="090191540A8595A6" modified="2020-12-02" version="1">MYEYPDLKETSLECQRKFNVCENSSGPLVFANPVGCWKEWAESCARKPEPLPVGLQLLVVIIIMIAIYSFIANTIVCIVFCLYDQLRLIKHYFVVNLAVVDNILVVVAVPMIVTYILGRNKDAPLCQAQIVIDILCGTASIVSLAVISIERYIAVVTPLHYDSRVTTFRAVLTIIFTWFYSIVVSLITLVAFNTPNSPAVKNPKQCLFFGGEFVIFITVSSFVLPVVIMGCAYWKIFVVAHVQAIRIQAMQVSSNLQEQPREGERQTKFKGELKAAKTLTIIMGTHIICWCPLFIYXLVVTFCKDCRKSINTIIAHYVILVLRYCNTLANPIIYTGINRQFRAAIKKFVLRKRGNEDLSGATVYTQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFH8</accession>
    <name>A0A6P8HFH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Follicle-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554541.1">
        <property type="nucleotide sequence ID" value="XM_031698681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFH8"/>
    <dbReference type="FunCoup" id="A0A6P8HFH8">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="GeneID" id="116291510"/>
    <dbReference type="KEGG" id="aten:116291510"/>
    <dbReference type="InParanoid" id="A0A6P8HFH8"/>
    <dbReference type="OrthoDB" id="5971428at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="169"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554541.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="53702" checksum="86C676CCCA652E1E" modified="2020-12-02" version="1">MNLSGNTDLDLSLLNFTNMFPRLTVLDVSGIPNWLNSSHVKETLGMLQVIRGTPLDGQCLRCFLKKNSNTLNISLAAGPWMNAEPMKPPLQKYSGCYGNILYFKDQYYLNFQRLGYDISCQSVDFRCFNGYSKLSFFHNYNVEPLNRCWDQMNQSSGFLFVLATVAITLNLTVVIATVRSKVLRDNVAQFLVSNVAMGDMFMSFYLLLITTTRASVTYREMMDLLRTPFCYFVGFVNVMSQGISAFSSFVVSVERYLAVVYCMDPNIRIFPHVAKCCLAIVVFISFVFSILPFTVLSSVYVPDSHCTPVSEPTSGAIEYMTIPGGLVMIAYFLTLPMYTHMYISVRSSSQVVGIQREGRVARKIALIVFSNMAFFLLPLLFLTLVNYTALGDIFTMMEKGIFWKTFMYYSFATNACLNPILFAFRNEKFRQELKRQLHLTPITRVGLVQPPSHITEKTSKGHQNKSKTTRVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFN7</accession>
    <name>A0A6P8HFN7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292114</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555224.1">
        <property type="nucleotide sequence ID" value="XM_031699364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFN7"/>
    <dbReference type="GeneID" id="116292114"/>
    <dbReference type="KEGG" id="aten:116292114"/>
    <dbReference type="InParanoid" id="A0A6P8HFN7"/>
    <dbReference type="OrthoDB" id="10051210at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555224.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45887" checksum="DA3B86FC9B0703C0" modified="2020-12-02" version="1">MPNNKEQALKKAIWLKGKFASNDRYFAEENLVTEPGKVWYLPHHGVYHPHKPNKIRVVFNCSAKYNGTSLNSQLLQGPDLTNSLIGVLQRFRREPIAIMGDIEAMFHQVRVPPQQCDFLRFLWWPDGNLEAEIQEYQMLVHLFGATSSPSCSNYALKKSANDAEPLYGNLAAETVRRNVYVDDCLTSVKEEETAVKLIDDLPKTCAYGGFRLTKFVCNHRNVLQSIPIQECASKFVSLDLGQDSLPIERALGVQWCVESDTFGFKIMLSDKPTTRRGILSTVSSVYDPLGFVAPIILPAKKVLQDLCKEADLGWDDEIPSEHQVQWTKWRKQLPLLDQVTVNRCYKPPGFGVIVSKQIHTFSDASTMGYGSVAYLRLKDNKNQIHCTFLFGKAHLAPIKVTTVPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFU6</accession>
    <name>A0A6P8HFU6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FERM, ARHGEF and pleckstrin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554686.1">
        <property type="nucleotide sequence ID" value="XM_031698826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFU6"/>
    <dbReference type="FunCoup" id="A0A6P8HFU6">
        <property type="interactions" value="1354"/>
    </dbReference>
    <dbReference type="GeneID" id="116291639"/>
    <dbReference type="KEGG" id="aten:116291639"/>
    <dbReference type="InParanoid" id="A0A6P8HFU6"/>
    <dbReference type="OrthoDB" id="6019435at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13193">
        <property type="entry name" value="FERM_C_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01220">
        <property type="entry name" value="PH1_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13235">
        <property type="entry name" value="PH2_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000040">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000046">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041788">
        <property type="entry name" value="FARP1/FARP2/FRMD7_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="691"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="909"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554686.1"/>
        </source>
    </evidence>
    <sequence length="1261" mass="144492" checksum="1A6E0DD00E363BD0" modified="2020-12-02" version="1">MARRSYEVNEEGSGGQRRGRRKAAIKVCMLDDSVVKFDVESKEKGDVLYKQVYEYLNLEECEYFGLHYYDKTDNLFWLDQQKPINKQIHDMSKVLLRFSVKFYAPDPSMLQEEYTRYMFALQVKRDLLSGRLKCSESTAALLASYIVQGELGDFDSLTCRPGYLAEFQFFPEQNVDSEAKIAEFHKQHKGFSPSDCDYNLLDVARRLEMYGIILYPARDKDNVELDLAAANMGILVFQSGAKINTLSWAKIRKLSFKRKRFLIKLHPEIFGHYKDVVEFQMGSRDACKSFWKVAISTHAFFRQSQSQSPPKHRPKVFSRGSSYRFSGRTQKQIIESTMENSRQQLAFNRTQSLKTPNRNNTPRTSQSTAKPYGGFGDAETRVVESAPVRPDEDQHTTDTPELQIEGLPLENGMDAMEEESDHEELHEPGSVIKVQSAENPDEDIPLKDLDHEPDMMRDESSVSSVSQQDLEWQEEVISELPPQNEIQHMAPNEDRNRDIILPPGAIEIECKPQPRPPTPIEVDGVESPPPPFPNEEVEDEEIASKEFRPVELARDEQEEFPTPPMETLPSPPPELLRDSPDPDRMDEEPNNMPVVQTNGYHEQKSHEPLQITCTSVVKVQNGEVSQHGKGSSGSRHSTDDDAEQRDGHDNVFEEQVSPMFRSDTEASPPASPILVTALKSEQTLSKSGSGAAYTIAKELLNTERTYVKDLEVITISFREVVSPPGVLPDSSKNLLFSTIDPIYDFHCTFLAELEERMALWDERIAENAKPPIFGDLMLSNMKQIKRYVAHLKRHDQVMLNLETATKKNKQFDSIYKEFETQKVCYLPLNAFLVKPSQRLLHYKFLLERLLKFCPSTNPDYKDLQAALVELGNAVRETDETMKKLENVQKLIELQRDLIGVEGLVQQGRDFIREGCLQRIARKGPQPRMFFLFSDLLLYTCKGVTVTNQFRVQGQIPLHTVKVEDVGPDLHGLYPFTITYSNKHMVVAAQSEEEKYKWLEDLNSVVRHAKEMATCSQCMYNRAHHMFKSPDGRNTKYFCEECYILVDEDEPIMDVLSGQTGTYLEHNKNLYNGDNQNGDNRYKILPLPTPVTIHRSSSGDDGSDDEATSTSPVSSLDRRHAHSNTMSTRRVCWHRNTSISMSEHALSVRNHMSGDLLRKFKTGNRWQKLWVVFTNFCLFFYKTHQDDFPLASLPLIGYLVDLPAPADQIDKGLVFKLQYKSHVYFFRADNEYSFHRWMEVISSATQSSTRSRIFSRMESNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGB4</accession>
    <name>A0A6P8HGB4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554003.1">
        <property type="nucleotide sequence ID" value="XM_031698143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGB4"/>
    <dbReference type="GeneID" id="116291020"/>
    <dbReference type="KEGG" id="aten:116291020"/>
    <dbReference type="InParanoid" id="A0A6P8HGB4"/>
    <dbReference type="OrthoDB" id="10585663at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554003.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11506" checksum="0F3395D74144ED0F" modified="2020-12-02" version="1">CYSQALCPFFLQESNSRNAHIDGRTNESCEQNIDIHGGERPNQPTEHDEEPIANDNAPANSSTSSVNANSLNGDFNAIQRQVSTNMLYQSNILSFLSYICYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGE3</accession>
    <name>A0A6P8HGE3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031554033.1">
        <property type="nucleotide sequence ID" value="XM_031698173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGE3"/>
    <dbReference type="GeneID" id="116291050"/>
    <dbReference type="KEGG" id="aten:116291050"/>
    <dbReference type="InParanoid" id="A0A6P8HGE3"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="97"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="557"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554033.1"/>
        </source>
    </evidence>
    <sequence length="763" mass="87461" checksum="F98CDD7FB34C2D8B" modified="2020-12-02" version="1">MSTNTSHKDCGRQRTQGMSRPSVFSILILIATMNVAIGGNENSFLKRTTLMDGDIHWKGNEELLQHRTNQSIQVCNTSKCQEAARYIKSSMDMNVNPCDDFYQYVCGGWERNNRYRFEGGVAYYPIPHILRDKTNDYLRTTLSNGIHDKVADEEFLRMPIELYKSCMNIAAITKLGDAPLRELIKKMGNWCIDGVCAGWNESNWNFTKVLLTIHKDYSQEGPLFSIYLTADIQNSSRNMIVIDQAGIKLQKDLYSNIQITEKYKRFIVEIGKLLFGRDKEAFIATKAQEIIDFETELGNITVSATDKENSMYETMSLSELEIEAPGFAWLNYLNELFAPTTITPNETVKAPTLPYLKKVMNLVNKTKKSTLANYLVWHGIQDTLFYLSEPYRNLSVNFKNIRYGSSGDKPLWEKCVSYTTLAFTDVLGAVYINSDLTQHRNAKNMVINLVHEVRQAFKDNLDFVPWIDNTTKSKMLEKAEAMIDRIGFPEYLVDKTQLNMKLEKWRGLIIRNNTYFSNRLAIRHAEHKNMMENLRMPIDNERASKPNNLEKNIKAMEIITLSAIILQPPFLYPDERLRSVNLGSLGSVIGHEIIHGFDNKGRMFDKNGRKTEQWWTNSSLQAFKELSKCFVNQYSKYIVSGKYPISGQRTLPENIADNGGLYLAFKLHEARSNGTNAQIWKLPGLTNFTDDQLFFISLGQTYCSISNDYAKYYITEYLQHPYDGYRLNGTLSNSYDFANAFNCATTSRMNPVTKCSMWLGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGP3</accession>
    <name>A0A6P8HGP3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sulfite oxidase</fullName>
            <ecNumber evidence="7">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116291921</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031555016.1">
        <property type="nucleotide sequence ID" value="XM_031699156.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HGP3">
        <property type="interactions" value="903"/>
    </dbReference>
    <dbReference type="GeneID" id="116291921"/>
    <dbReference type="KEGG" id="aten:116291921"/>
    <dbReference type="InParanoid" id="A0A6P8HGP3"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="UniPathway" id="UPA00096"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02111">
        <property type="entry name" value="eukary_SO_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000002">
        <property type="entry name" value="sulfite oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031555016.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61388" checksum="D269817C0403ACED" modified="2020-12-02" version="1">MFRQAARGILRTGGGGFRRAALSGRVTSTKIPKRSVSGTSTANQGNSQGYLILGICTGALCGAALIYRKQNGSHAKQAKESKSKIEETGFISREEVAKHDNRKTGIWIAYDGAVYDITEFIDNHPGGSSKIILAAGKDLEPFWSMYPVHKKEEVRAILEEYRIGSLAPEDKAKVVDSNDPFKDEPERHPALKVNSAKPFNAEPPLELLGENYITPTDIFFVRNHLPVPHLNEKDYKLELSGEDMKKVSLFLKDLKTKFKKHTITATMQCAGNRRSEMNQIKQVKGLNWGQGAISTAQWSGALLKDVLEYAGFDQEHVEKYGIEHIVFEGYDKDITGTTYGSSIPIQKAVSPQGDVLLAYEMNGKDIPLDHGFPVRAVVPGIVGARNVKWLAKVEASKNESSSHWQQNDYKGFCPSVDWDCVDFGTSPAIQEQPVTSGICHPTPGAQVSRDEEEITVKGYAWSGGGRPIVRVDLSLDGGKNWTTATLDGKKQPYGRAWAWSLWXATLPIPQGVDKLDIICKAVDSSYNVQPDSVAPIWNLRGVLSNAWHRISVPVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHR2</accession>
    <name>A0A6P8HHR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Nucleosome-remodeling factor subunit BPTF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116291468</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554498.1">
        <property type="nucleotide sequence ID" value="XM_031698638.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HHR2">
        <property type="interactions" value="2832"/>
    </dbReference>
    <dbReference type="GeneID" id="116291468"/>
    <dbReference type="KEGG" id="aten:116291468"/>
    <dbReference type="InParanoid" id="A0A6P8HHR2"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15559">
        <property type="entry name" value="PHD1_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="15">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="271"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="2346"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="2405"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="2481"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="536"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1059"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1253"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1316"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1711"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1950"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2165"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2313"/>
            <end position="2340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2009"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2245"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1059"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1358"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1711"/>
            <end position="1721"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2165"/>
            <end position="2185"/>
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        <location>
            <begin position="2217"/>
            <end position="2227"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031554498.1"/>
        </source>
    </evidence>
    <sequence length="2569" mass="283089" checksum="AB30DC963AF888ED" modified="2020-12-02" version="1">MKRGRGRPPKTPVYSSKLLKSNRRGSQHGGQSSTRVCSPQTGEGVKTRESNRSTQRRSYFEGIQFSDSDSDSDSSYESSISTVSSVRSYKIPRVIPMKTVTPLALPRSSDDIILPPEHVLQGLGIYEVLRQFGRILRLSPFRFEDFCAAIDSSEQSALLSQIHMALFRALLQEDETNGYTFAASDEKDSLNIFLHEVDCFTWPEHIRSYFFSDKTEFCDLLDTIKGRDPQHPFPFVSISDRLKVLQRLCDLFLASNTVREVIINEGIVESEDHCRNCSKMGDLLCCEACPAVYHLHCLKPPLEVVPEGDWLCPICDQHQLKGVTDCQPAWIKDGWLRHTPLGTDRQGRKYWFLSRRLFVESEDELVLYYSSKPHLDELIEYLEDDGQERRLLSAIKTKYNTIIRQMGITESLIEASRGDMKSGLLARRKKGEKQSDSVSEGLTPQESHSSKVNLTFVPDTAVAKIVTKTNQETVAAAAEPVIDRRTAVMEQRKETSSNHLSSDVQEVDQISHVVTKGDSNHLSSDVQEVDKISRVVTKSDSNHLSSDGQDMEVDHKGDSKQSSIIEHIKDKHMTSTTQPKASNERHEESIPDCNPSDTSSSPAKMLVSNKETTVKQESNAAKGPKKNDSAASLQAIVKQENKPDNKDCLNVEESSLTNNGLVKSEQQKAIVDDYDVKGPFFRLGMEDNFSGYVNHFATDPLALNRQQHMENKERRRAVSNKFSVFNEFKLSGEIFGPKDVILNTLRCSIVNLENNIPAAFMHPVWPVQRSTWVRAVHMSTTPVEFAAALCFLESLIKPVCFLPVWNDSLGHTELHRIIVETKAEKKKREHKDEEEDVDYRDRVFVNYSWTPIHQIWKQKGEEYRIFGGGGWTWESGMPSRKRKRCLTKDKKDFECKKQRLCSVVDNFVKRREQKKMEAERKAKAKLAVATYKANANPLPKGGAALSTGSGKTVSLHTSVPLVNKVMQSGGSTLVNANVNTVKTPATNVETLLINSTSQSTGISVMPATQMSQSAGRSVTPATQMSQSAGISVTPATQKSQPTGISVIPATQLSKSAGISVTPATQMSQPAGRSVTPTTQLPKPAGLNVIPATQVSQSAGISVIPATQVSQSAGISVLPATQTSQSAGIHVIPATQMSHPAGLNVIPATQLSQTAGISVMPTTQKSQPAGITQTLLTTIPEVPLNLQTFAQSPSIYGSSAVLGTGVPTVTVNQPLIPSGTALSAVPKTESISIDMLLQRSTAPSHRVMSLVPQSTAPSHXVMSSVPQSTAPSHPVMSSVPQSTTPSHPVMSSVLPSTAPSHLVISSVLQSIAPSHPVMSSLPQSTAPSHPVMSSVPQSTAPSHPVMSSVLPSTAPSPPVMSSVPQSTAPSHPVMSSVVPSTAPFHLVMSSVPQSTAPSHPVMSSVLPSTAPSVMSDVIPDTKPSDVVQESVGNKEDKVLIKKPMPLTGQSMVTGIVTTGPENRNCQFTGVSGNNVNKNVVIPKIPPALSIPVQASKQEMSPLSFCGATTVTPSLSTTSSAMPIKDLNVITSNSPVLGPGIEKGVAAIAVSVPGSLGKVMPSVKSTGQCVPMKTGVKHTLPVASKVPTQQGTISTPKLATHSLNSNKVTSSPSLRAIAPQPRPAILPASLQPGSKTSPQGATQITIPIVQGNVMQGTNVLKLTTPVSVNPGTPVSNIAALVASLPANMVSPGQTQLIRFVTPAGATITVQGTIQTHPTGKTGNSPGGPSGTATISLPKSIATNQLLLSSQNTKPVPVAPKTVGTSTIHKTVSLARPQQPSVTKMQNKTLDQKEKYPVLEPVIKDPRKLLDRQISKWRQNRYSMKSVYQLQRHRRRVFGRRAGMKEVPDFMYVTRGSGVNWPAGFPRPSFKVAWRYRSQSLRTLAGAGLQARILHACLKWEDINIRPPRSNSSTICTSTGTTTTEIINHRYVNPDGLHCEYLVRKILRNLYKPVTESPKPPPPTVSKRGRTLRPKINLNLDDEEEETIKKGPRVVEEWCPEEKLELWEIRQYNERKERERALEREKKMQEEALRKAAELRAAAIQRKQQEQQAKQQQQIMKKKVQNAIKTQQRKLSNVNQNVSRSIVNTTFRSVVSTSPSTTQVLQTSVARQPLPRITNLVTQYRPSSLSQPRVPVASPATVVRQVTRPQINYRPLATTVQSKATLSTGTKVVHTSQPVIRSSSSTNHAPKMKHSSKELQQAKQQIAKAKVKKSGAGGAQNANRKATSLESRQDMNRMSACHKAIDYIISKIERNEELERQREAKRKAVVEKQERARAVKLDGILYKRKEILKKEIIRKRAQLEKELTVEIEKEIKKDQKSRKDTARKRKRDSESTPEGPSIKKHKTDQLYCVCRKPYDETKFYIGCDMCANWFHGTCVGVTPEQAAIMDDFTCMECKKAQKGVEKEELYCLCKQPYDEAKFYIGCDSCHDWFHGTCVGISEYQANLLTSYVCPQCKESQSERDVQPLTKKDLDSLKRLLRSLQSHKMAWPFLEPVNADEVVDYYQVIKDPMDLSKVEDRLTSNYYKTLDQFNSDITTIFDNCRLYNPKESPYYRCAEVLEGFFVKKLRNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHT5</accession>
    <name>A0A6P8HHT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552130.1">
        <property type="nucleotide sequence ID" value="XM_031696270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHT5"/>
    <dbReference type="GeneID" id="116289373"/>
    <dbReference type="KEGG" id="aten:116289373"/>
    <dbReference type="InParanoid" id="A0A6P8HHT5"/>
    <dbReference type="OrthoDB" id="5988919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552130.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30485" checksum="C3AA880F494C4C8B" modified="2020-12-02" version="1">MNRDSAIIEQECFSYGINRPEVQFVPNPSSRSSQRLLTPMYTNEENQDTSNNHHYEDPARLAQQSLTREHVGPRKKTNDLYEMSIPLQSLNKVKRGVRSMSRSSDDSDTGYTYPRREPLCHRVILYLVLLLSLTATVLVILMIAGMVGPKCHCGNGTTDSKETSSQRQSFSEKPLQEAITSLKSNLSRMEMLLVSRKYGYVIIGPFCSTIGAKEYNLEVYIPRSGGNPNYECTCKGESTLFPPQQDPDNPGNSDKKVMCILHYWLCPNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI90</accession>
    <name>A0A6P8HI90_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 76 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP76 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031696482.1"/>
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    <dbReference type="GeneID" id="116289534"/>
    <dbReference type="KEGG" id="aten:116289534"/>
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    <dbReference type="OrthoDB" id="2162143at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CEP76"/>
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    <dbReference type="InterPro" id="IPR028926">
        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
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        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CEP76-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="537"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="10">
        <location>
            <begin position="790"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="9">
        <location>
            <begin position="938"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1"/>
            <end position="54"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="13"/>
            <end position="25"/>
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    </feature>
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            <begin position="43"/>
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            <begin position="357"/>
            <end position="373"/>
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            <begin position="380"/>
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            <dbReference type="ARBA" id="ARBA00005400"/>
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            <dbReference type="ARBA" id="ARBA00015706"/>
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    <sequence length="1096" mass="121854" checksum="02C56A65E9E89D6D" modified="2020-12-02" version="1">MYTLGGEYPESPAESEESVTDESPDNDGSHSSQAASPFGARAVGRDFPSRRESTAEKQRKWAVRTFTLWCNSEGVTKPVEEMQPSELNQLLKKFYKEARRKDGCDFSKPGLTNIRNALDRYFRSQLNITILKTSEFAEANKAFDEKVAVIEGNAASPWRHSVSISPQDMQKLLLSGAIGGTTPLLLLRACWFNILLHFDIGDHLKQRRLSKQQFVIHIDAAGRENVKMISTSNPYVQSKFGVAGTTMHSVPGHPLCPVALLKKYLLKLHPGSDALFQCPVQYKVDDSVPVWYEKQAVGVHALEGMMACLSKEAKLSRIYSNGCLRKSSSLVYLQCGFGFNPRELTPDTPTASMVTNNLVPSTSGMPSLSQSSLEHVPHLSSPSTPPVQNLVHSSSDQSRPNYYSTMSQPSLSQSNKFENMGSPVPESSSYPQINSTISLAKGDTCHTSKRPGQPALPHLESGFTGQSRTAIGVCMPTIKMEQGDTDVCEGVQPTFPSESLDFPSVTETITVKQEGRTSITAHVFDRQSPSVVQDMCNKTYLHMEVLGGKSFMELDHSLHSTGKEEQSKSPTLVLHLHFRGQRFKSNPTPCKSEPSLKGDFFLELHNSPSADGDVLLSITDPINLILSKTETTGSNSLIGSHSFEWQKVLKEPNGVLSVNVDINGMGEENKIMIGSLELRFQVLPHRRQIVQPQALENHLSSIHRHISERERRFMNYARQWWKSYISSHQSHSRQQVKIFAQNECGTSKPVISYITPIHVGWLLDNPRHAAQFVSLLKHEEECSMFGIKVDTWSSLHALLCRGKGSCEDHATLLCSIFLGFGLDAFVCLGTRDTGQPHAWVMTRQTDGLVSFWETLTGQCFSLSEGLSTVCSQFRTLACVFSNTCFYANIQANGLISQCDFDLNNPAKWKAMDADAIYAICGSEIQPPLPVPPSLTPSTIDVQKTSQALEEELRSLIENYRQGKGLETKWDNNLSNILSPILTAQESEAKTGQDLKREELYDPVYRYLNRSFTLQSVTTRITHLNASQAFSDMQLSAEYKSLIDYQGNLMEFALRVHVFPYPESACAVWVILGAKAPANNGEVAHEWKLVQLQRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKY7</accession>
    <name>A0A6P8HKY7_ACTTE</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293178</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC116293178</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031700571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293178"/>
    <dbReference type="KEGG" id="aten:116293178"/>
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Death Domain, Fas"/>
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        <property type="entry name" value="DEATH-like_dom_sf"/>
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        <property type="entry name" value="Death_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="296"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556431.1"/>
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    </evidence>
    <sequence length="409" mass="47112" checksum="9106089EF19CFA1B" modified="2020-12-02" version="1">MSAVLGILSSASVFPPDVQKLARDVRSDVRNPWGHCKFLEWDDTKFTRCFQLMRDLLQALKLPEDDEKRITDELGEWETIGIGADSLVKFIEFAQVEIKRLSQEVKRLEANEKDEAEKIAATLRDILDILVKENRDKDKKLEALDTRVTALEQNREYSDKKIAVVAQKQEKCENRLETVEQKVKDITPITDEDPVECLGIVITDNFNDLPEDIFYLMSTYLDHKDIQWIKEAPWKPEKFLRKFPKKSCDKPRKDCLQHLVDVLCEKFPVAMSGLLELLGVGKELVTTPLKDNKELKEKTIEIVSRNPNICWETLAGHLXVDEKILKKCREDYSGDTLEVTIQMLREWIETSDESXTLEIIFDALRLCGYRKTGEELASYTTGKCKDKIAQLIQAEQSRXAESSRTHEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLX6</accession>
    <name>A0A6P8HLX6_ACTTE</name>
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        <submittedName>
            <fullName evidence="4">Centromere-associated protein E-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290693</name>
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    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="4">Tentacle</tissue>
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            <begin position="144"/>
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            <begin position="349"/>
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            <begin position="516"/>
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    </feature>
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        <location>
            <begin position="761"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1270"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1507"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1574"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1770"/>
            <end position="1897"/>
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    </feature>
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        <location>
            <begin position="1934"/>
            <end position="1968"/>
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        <location>
            <begin position="2018"/>
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            <begin position="2239"/>
            <end position="2459"/>
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        <location>
            <begin position="2491"/>
            <end position="2525"/>
        </location>
    </feature>
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        <location>
            <begin position="2606"/>
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            <begin position="2948"/>
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            <begin position="144"/>
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            <begin position="166"/>
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    </feature>
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            <begin position="697"/>
            <end position="726"/>
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            <begin position="1107"/>
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    </feature>
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        <location>
            <begin position="1155"/>
            <end position="1166"/>
        </location>
    </feature>
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            <begin position="1204"/>
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        <location>
            <begin position="1373"/>
            <end position="1391"/>
        </location>
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            <begin position="3243"/>
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        <location>
            <begin position="3296"/>
            <end position="3315"/>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031553657.1"/>
        </source>
    </evidence>
    <sequence length="3376" mass="391811" checksum="B777EA544CDC5354" modified="2020-12-02" version="1">MLIGLAYITAMMADSARDSSKNKSSLIKHSNNSEDALSPLDLKDILDRLIQEEHEYKDIKLSTVRKLTADMTERGRKLGTQLEAIHSYVVKDCSNVEEGQDQRENCLSEELADEIRKRTTSVDSEIKQLENQMGQLQRTLVKGKARRESLRHRMSASSQAGERKVSSMSSSCSSMPENEELSSEDYKSKIELLENEKLELLEDKKDLNDEIKFLKYQLQYRLEVQSLQNGRECKAETHIKLENENKTLREEIAKMKERFEKIKKKFEESGHVEESLLTMTDVATDSSALIESELERMHSERKILLSTIMRMQSMEKDEDEEVSYADFGVQCNLVKIADSMXEKDVTPLVAKLTKENKALKKHITDMQNEIDEREEESKTLDEENYKLTEEKRTLEDTINKLRTQINETLDTTLDEIEHLHSFNEDLEMKFKRTEAKNKEILLALKDLQNKNCKSLENLLDQVENKSTMEEVFEFLDREVGTLIETNSSMTIENGEKKTNQERNEDKQFTSNLLNEVKNCKELLESQRSHIRNLQLEKRDIEEGYTKMKRELLLLKSNKQRARENSKELQFLKKRRVKSLNDGTLGGVETKDVLVDKESLQREIKRLGAVKTQLENNVQKLKKEKATLEDEKVCLLGSLYHQLERNESLEIQIEELTVALEQWEAKADLENDVFERKTEENGKEFGSESAEQGFPRNVKVEGDKESIEKHVTNEDKESLELPGKLDGESIAPAKLETESNGSLDTEDIDSTPPTSPVMSVVSSAAEESLQELKQKIHALGEQLRYVQESVNELETERDKLQEDLDESKKNEKELRNVXIQLKRENGIHLDKLAKSNECAETLQVRLREANEAKEEVMESLEEANEEKFVSKRHCEVLNKKLQEVTKQRDDFRSENNVLNEKAKFYQQNIKEIHELIDKIDSVQVKDAASGIKEDEESPENWAVEEYEKSGAEDDDQKKSIVGLKAVLNKVSEMKKKHDEECDVLKDQLRALNTDKEALHKSVRETEDKKKQMKGFIAKLTEEKEKVTEQLDEIRQQKNNLAEALENVYQSKEKLQNRFAEALNKQEQYKRSLVEALDEIKNLKESLCRVVNEHETMKESLLAANREVERLKSEQQPHKAELEVIPEEEDKEMRQDQNEKELVSENLSIAEENSLDDMSKSDKDQNNNKDDLLKIIDKLKDSVALLSQEKLKFEARIKSLLECKESRDDDTNDATKAKESKEGEQRECVADELSNEIPESSDNIDTPKDGEETNLSKQFSRNEIIFEIDKLAVQLEANIEQLSSQLQYLASKQQQQDTVDKEHLMEWFEVISTEKENLERELESSSKNNLEFLEDIKKMGEERQRIKCQLRGVLYGMESDLCNGKPYEQDMGEMKEDAEMSTKQQENELREESVPEEVDDLIKKLIMMVKTKNDRLNEKELENAQLLQQTKELQEENNSLNEKIVDIFENSKXFSSSEELNKSIKETEALEKQVEALSNQGALLRGEADERVQRLIELEEKMIATMEKKLELAEYAKALKSQKDSLEKNCEQLSLEVEGLKISRDQLLAXKGVLDEKLKTEIKMLKACNEKSIKEIQGLSQQLMDREQDLETVEIKLDSEEKKKIALIEDLEKSVPKQEELMNKTSELEQNAAKMTKELQEFSKENEELNKLINQLIAVFDKEITGKDSASPESIKNIEAVQKKVCELREWIMHAKDELKKQTNETNFLNLFVQHVDIKISEILDEEDMTSEKMLTEAEKESEVPQGKENYDTIKCKLERLIEIIKKRFGSSVSLQAELERISEDNERIAKELTSKTEFLQTMRNSYEQLLEERNVLAQKAAEEAIKLKEEKQETSDTDGELTHRIICNNCKKLEKEYDDLNTKYLNRNKESSELFEKCRHLKEQLILLKQQQEDDEKEETRDSGEDLVFPQEYHAEPEACSYVTSGMENDMKEMMHQHHRETNELKKEIKLLENELNSSKQENEGLQSLVISLRSELDKPQQPEMHKSTDSEQLHKTLAERSSSVKDLNEKLGVSKHFMQKILDENTDLKENVVMLEKEAQDMMNEMEVLKAEIDLKKRALIQAKQEASITESKSHKLEEEFTSLKKQLKTRGNLLATLEKDKETFKVSLREAQSELVLLKKQNNELTDLLNSGEQRRLETENLIKKLKQSCDEMTIKFENSTAEKKRNEELLEHEKEHSDDLKGKLEKLESMYEKTKEKVENLTGELRKDKTRRDREIGNIKQENAKLLADEGRAGRECDSLRLQLDEERQKNERLAEDLKELNKENQHLKKNLQLESDKKLKTSEELKENKKEGRRLSTLTGDLKSKIANLEAIITAVKKENEHFKEELDRAKESNADLRSRLIEVDEDKEDLEKIIDGLREKRQKLYDEIDKTLAERDDFEDELIDTKKEMTKEIESLIKENRKTNDKVQQMENVEISLRKELEGHKQSKAAIAEENQQLKKNLEKMKNELETSHAKYVVNTEAEMSFSSSSQEKEDYIRQLKEGQYEIKKVTCALEKSKKEIDKLKTECQKLKEMDREEKRAVQEEMVVKEGMTSLEACAVTDLDKTDKRGETPLNLEEQISKYMIENMRLRASLEERDCKLMTLQGDLYKLSKEGVQDELKVVTLQRECKTLRQTVQKCKETEENIKAALHASNSVQADLRRRLRNIVIDKEKYEQECKKLILEKGSIEKVMVTSTEMPAVSQIEGELGRDHLAKAQSLETARKEIVILESQVKDLRARSESNRQVVVQLLNEISIELNRARNVLRPLVDTRDETKMDAQSSEADNLRKGISDLRNAVDRLEGTVMVKTRGQDDSCLITENNNLMKELRDVTEEKNVLSDKLIYLQEKLNDILEERRVLEDIGADTRKELTALVTCLSAEREEKISISSEHSEMLAKLQEADKNEIALLTTIRNLEKECEKLCERNRLLEMKVDGFNTSSDKDEIQVARTSAIETPGKEKQMTLESLCKDYKKVSAVCRQLEDRNKILEDEKKSMVEEKYLYKKKLDTKNQDLLAEVKSKEQHLKKVLEENTKLLEIRKTLEAQLRHLDREVMLLKDRVVCSETEKERLEDANRQQQNEIQEMYLHRSRDNMVREKLENLFYENTKLKEQKRMLVARLQSLERDIKSQLLTIRNLQHEKEDLNARLNDVEREKWQEQSHRRHLNDLLEKHEEKSRKEIDNLNEMVRKLTIEKDKLRKEGPHLDKMTFETSRLEEEHIDNKGIIDKLKKENATLVKESSLLRRACEKLKENRKASKTLNSSSXEHSSSSRLSPRISSRQMQGSKHSSFSSFDQTSLSNSQHSFSADKTDRGIGSTSHDYSQQQTPPVNQTRRLVSRDADATSICSQECYCSPILSVVNLCPIEIQQSTELSPSQQCPACNKKKTSVVISEHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMA3</accession>
    <name>A0A6P8HMA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein bark beetle-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116290810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553780.1">
        <property type="nucleotide sequence ID" value="XM_031697920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290810"/>
    <dbReference type="KEGG" id="aten:116290810"/>
    <dbReference type="InParanoid" id="A0A6P8HMA3"/>
    <dbReference type="OrthoDB" id="5985067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="268"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="1157"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="13">
        <location>
            <begin position="1506"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="2047"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="2051"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="2068"/>
            <end position="2077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031553780.1"/>
        </source>
    </evidence>
    <sequence length="2102" mass="239065" checksum="950AB4393E45FF69" modified="2020-12-02" version="1">MFALQGTLASNAFLDNLGKVVTVREGTNCGDRHKYPIRVQISSNRFENNTGQYMVNIDLQPWYTIRSAVLRHNSFVMNKQTKLPSRFYSRMTKDAVIVLKEGTFHILQNSFENPNFNYQVAAALVAHGRVINASHNWWGTKDECRIKDLIFDKEDRLDLVKADYFPYLLSNHSSDIISSNTTRPLCFLKDSHLGGTLNRHLILSNKSVPYKVVNDLVILPKGSLVIESNVTLIFPPRSAFVVQGSLNIYGEESATVKFTLDKVVDSRIRLKNGWYGNLEIKINSTWMTLCVKRNFYFQPEMVCNHFNLEYESYNRYYPSGKEHGFINNLNCDHNIALDMSPCNYENLRYTPRCDDYVLYLRCKRPYWSGVHLAMTKAKNSIKHLEIHEGGHNYRTDLKITSAALRVDFDDHVLRNIXVKNSASVGVQVLYSNPFKSVPTLSSSLVEGTESNGLQISFSHTALDRVNIIDAKGNGLYSKSLWNDLDLDAQRMSDHKFIHHVSNCKEKTIFVKEGHTKYLIFSPIENPVSLTCEQEIYTTNSSTIGVQMVYKNLMSHSWYIKACSGNKEWELIDMLWEDRPVLYANSSRFSLQFIKSYGRRNILVHLLVFTLNATNTMMSQHGKLSMTNSTIKKTSESAIYIYGNQLQSINLQNSTVQDSLKNGLEMTLSRTSLLIQSSVIERHSQCVFLGYQKYFIGIRGNVLISNSVISECSENGIYILSHGRKNITIHDSSLSNNTGIAVHIYGSISDTSLYIKGCRFYWNQRQCINANGKEDSGSSIEFLVVNNFFTNNGGRVINIEHATSLTKWLIEGNVFFNNSEPSVFSIGVEFSDVSYAVKNNSFISNRCTKDAVIDLRYNARFVDINQNTFVGNLGPSVIVQTAVKSLPLMIVGNTFKHNVCPGCPILKCLRTEKETIMMENNTMINNTGHTMISIQAVYDINSKTAYQTLTLVNNTIKHNHPSTSSAFSEVKSCIIELNGILIFKNVQWRRNKLSNSQYDYELCLHTLGLSQLPQLNANETWWGTNEDISRRVLSFDINYEYGIVNYGHFLALENKVLKTKVYDADSAFDELFEKSILRGRIHKSITLRRQNSPFKVLGDVTVLPDTVLTIEPGVTVQLAPYASILVLGTLIARGDKEHHITFKHIDNSKNTEALPFDIRLMDGDFPWHGRLEVYHNTSWKPLCTEKWIRQNVIVACHQLGYDGPNLDMSPIRFGNTENNLTYPFEVLCSGNESSIAKCSKNSTCQNIRRCQSVVGLRCHGKEWGSIRFSRPPIEKINASNSTSVLEYVDIMYAGKRKSSNTSAIEMIRRVPIIRHIKVFNCSSGGLTIVLPDKNHKIEKSQFINTGGTGVTVMENTKSIVIQDSYISENNNGLLFIRWDDQLISSFVGQDGVFLCDNKMQTIDVKESEFLYFETTPAKGYTNDYPTVECQKTLRTEKGMGIIIKVLSVKGTQTLRVHVGQTEIINTETYGLKGDYLYVDFEEIQLSWKGTFSSQVVLLATAIELKDMPCTFIRRNHMCGWQSVLNKRVLGMSTNLAFKNVYDAVSGHTIGLPSYLYWRHEYYANLVSPMITPNATACQLNFEYSFFQHNYLWLAVILEEYENGKQIHSKLWSSDEEETQERLWMNTSIKIPLRNKPFRLVLFAHIKSRAWSRYIYFKNLKFENCSAENINVNGNSFTKNRKHSILLQSNVPIQQFSIKIHRNKLTNAVDDASTGTIRINTYNNPFYILNNFISNNNNGGVYATVGNSHGNLVIKSMIERNYFEGNKKETIYIDAGYGGKAFNIDIFGNNINGNNGTGAGQAIHSNIKLSQVVCTLEENFVYDNYGRYNLEIMLNKRTIVNRLIKVRNNTFYHNRGLIKDYVSTMYCNGPVEIYKNVIKNPSNLYELVTDRASSFRSINATDNWWGFGLPKIVGKRILDLFDDANLPKVNYHPYIRLRPPAAVPLSCPYGWSLYEESCFLYNGGPLSFHKAEEYCLMYGSHLLSSSQELDMSFIKTTFHSDKQSNSGIRMRVWMTNNNKISGYSVYEQDNNFIITPCESLQPFACSKTPVIRCPNNCFHNGKCVGTTCFCNKGWTGPDCSKFHCNNLRNCSGHGTSHRLQLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMY9</accession>
    <name>A0A6P8HMY9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291029</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554012.1">
        <property type="nucleotide sequence ID" value="XM_031698152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291029"/>
    <dbReference type="KEGG" id="aten:116291029"/>
    <dbReference type="InParanoid" id="A0A6P8HMY9"/>
    <dbReference type="OrthoDB" id="4369127at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554012.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23108" checksum="81C9FB38F87779BE" modified="2020-12-02" version="1">MHRERLFKGYENAAKQLQKCSEERTKHLAKKICDPKVNVGDHAYMRNRIPGRNKIQDAWNPTLYVVVKVPEDGSPIYTLRSVADGTSRRAHRSSFRLCRPMFEQQSTLREPSGPGKRPADSSVMSDDDDEEEEDVFYCVPRQPTKPKTTSEGYLDDPRVRASXQDWSAVQPLRRSKRLEEKQRSRQPTMNLVEVSTITYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN05</accession>
    <name>A0A6P8HN05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116293106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556363.1">
        <property type="nucleotide sequence ID" value="XM_031700503.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293106"/>
    <dbReference type="KEGG" id="aten:116293106"/>
    <dbReference type="InParanoid" id="A0A6P8HN05"/>
    <dbReference type="OrthoDB" id="5947829at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052304">
        <property type="entry name" value="PTTG1IP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191:SF3">
        <property type="entry name" value="PITUITARY TUMOR-TRANSFORMING GENE PROTEIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191">
        <property type="entry name" value="PROTEIN CBG20567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028279882" evidence="3">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556363.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35052" checksum="DBE6DC4EBCA9A0A3" modified="2020-12-02" version="1">MKGILLSLFVGLCYLHSVQGSWNLEKYRRYQLLKRERVKYCNQETPNCNQCLAKSGCSWCGRDGIFECSPKQICLQKTRCPSTPQHELLETYSRENVPSFRDVSVNFNPQSVASGANSCSERGNCSYXTSAGSCVWCEKTRSCLPHYNVSTTNKACGSDLWYKDQCLYSSKVKPCPERTSGCKECTADSVCFWCKATGNCSYYPHDAFVPDNCPSDSWYYKSCSHMELIVVLAPILCVLFFPILIFIVIAIVLWCMRRMGYKGMDDPDKAEEVHQSPPREKKPFMMSHKPPASKIEELKKKYGLEDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNC4</accession>
    <name>A0A6P8HNC4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554175.1">
        <property type="nucleotide sequence ID" value="XM_031698315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNC4"/>
    <dbReference type="FunCoup" id="A0A6P8HNC4">
        <property type="interactions" value="2529"/>
    </dbReference>
    <dbReference type="GeneID" id="116291185"/>
    <dbReference type="KEGG" id="aten:116291185"/>
    <dbReference type="InParanoid" id="A0A6P8HNC4"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000030">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554175.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41666" checksum="C61B0570AC750C2F" modified="2020-12-02" version="1">MSGKEVHELTITPITCFAFNKARNQLAICPNDNTVHIYKKSGNKWTADVVLNEHGQRVTDMDWGQESNRLVTCGADRNAYVWTLNDGQWKPMLVILRINRAATCVRWSPKEDKFAVGSGARLISVCYFEKDNDWWVSKHIKKPIRSTILSIDWHPNNLLLASGSSDFKARIFSAFIKDVDGKTNCDTEWGKKAAFGNCLAEFSTGSGGWVHGVSFSASGHKLAWVGHDSSISVVNADHDNKVVTVHTNFLPLRQCLWITEHSIVAAGHNNLPYLFTHDDNDKLTFIEKMDAPKKKEDTGTMSAMAKFRTLDKKGQGADESSSSSSNTTHQNAINKLELYSGTKDGATKFVTSGIDGRLVIWDIKTLVSSISGLKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPK0</accession>
    <name>A0A6P8HPK0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-2,6-bisphosphatase TIGAR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">TP53-induced glycolysis and apoptosis regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <dbReference type="EC" id="3.1.3.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556998.1">
        <property type="nucleotide sequence ID" value="XM_031701138.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HPK0">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="GeneID" id="116293675"/>
    <dbReference type="KEGG" id="aten:116293675"/>
    <dbReference type="InParanoid" id="A0A6P8HPK0"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556998.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31390" checksum="F8EADE08A06C50BC" modified="2020-12-02" version="1">MSKSSRKTKVPGKSALKNMIRFDLCVVRHGETMENRKNIHQGHIDTVLSDEGMKQAELVADRLQDKVFTHAFSSDLQRAYKTGECILRKNKHAKDLVLVKDQRIREKKYGEFEGKTQDEIKQLAQKHNFVLKDYVPKGGESIQQLAKRAVEFFDDLCKNIAQNAENGKTMDEGDKSLESRVQEASASTTAANVLITCHGGTIRQLFYHFSREIPSEFLCKGKDKICKLCPNTGVSEFEVFVGKTSXKAEFIRCTMTYDGSHLINEDEKIPCDEDHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSX9</accession>
    <name>A0A6P8HSX9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine-protein phosphatase non-receptor type 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558328.1">
        <property type="nucleotide sequence ID" value="XM_031702468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSX9"/>
    <dbReference type="GeneID" id="116294807"/>
    <dbReference type="KEGG" id="aten:116294807"/>
    <dbReference type="InParanoid" id="A0A6P8HSX9"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="204"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558328.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46189" checksum="99079D694507C11E" modified="2020-12-02" version="1">MSAKPFRFEPITPAYQPVTYNAVTLEPSIAVPGRLSQPSVNTWKNCIYRKVGQVRNNVENIKITSDLVSSVKQFIEERSFSSVVARKTAASLTKERTDVDHPVYTGSPSDILFIGMNTPYDVQLDQENNNAFEQQEEHQRMIIQTALMEINAICQSTGLAPMSAAAATKFLMARDFDVEKTVSLYNKYQSQRKLYRMENMSPFKNPLQEEIYSGRFTVLNTSDQDGAGVVYLSAKRLSHHTDHNTIINNIYFQMDEAIKSPEMQKNGLVLLYDFSQVTFKSCDIKLCAKILTLFKEAFPVVLKKVFLISPPFWLAARMRLLEPGLLRDLNAQTVSANVLKERLPVTCIPDSLGGTLAVNHLTWICQCMAVHSARIESGKHKLSKLVKRRPKKFSRQQSKRKQSKRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT95</accession>
    <name>A0A6P8HT95_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116292681</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRAT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555900.1">
        <property type="nucleotide sequence ID" value="XM_031700040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT95"/>
    <dbReference type="GeneID" id="116292681"/>
    <dbReference type="KEGG" id="aten:116292681"/>
    <dbReference type="InParanoid" id="A0A6P8HT95"/>
    <dbReference type="OrthoDB" id="10057956at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038904">
        <property type="entry name" value="BRAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331:SF2">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555900.1"/>
        </source>
    </evidence>
    <sequence length="964" mass="108283" checksum="4E5A09DB41CBCCB1" modified="2020-12-02" version="1">MLLKQETGVLNFLSDEKLVDKRPCCVGVSFALRLCGILWSKDYNVNDTSTFFELFAKSRENENLWDEAIVRHGYLTGLQSLTSSNEGQKWLQAHTGCLLTAVGCISDSSMFVASAAREFIAKFLLSSWSINVSKQDDGYSNEMKWLLELLQEKLFHDKQQPNNSQHQKMTSDHIVSVLDIVRILLNTNFEVGQEILRMSKVFANCVTAAEIADQIACRKLVDVINGFQINPSAQCTVDWDKLLSCDRFGPSGEKQGQSAQEILLTIPIKWYKKGMITLALDLITGLSLPKDTVSRCFPAVWPEILACLINAPMEVLMEKHLETKCNGSCETNTSDIGSLVTELLSLENEDVDTNIKRVKKQIQELLEPWMLTKKCQVESLLQILFTIKELVTKDESSFSQHVVNWIEFSLKILVNSSMVTNGDQKLLALDVKGNVKVIKTTLSVVTVLLQQLLRQPSLTDSNRNQFFHVLNTAILVARSSRTDPTVITSTLECIGALLGQGSFLFMSSTNKDLGSDAHLYYQRTKQDLGSLIHLRLRDQRWEVKDSALEFVGRLIKLNSALSYDILNPSILSLVWESVDDSESYVRSSAWSCLGHLACNPGLWAKLKEKERLTEFEVLKKIVHVLENESEAFPRRSVMDCLIKWSHDQHPIVSVILPDKMKLSSSTGLDKLKNTDSEIRSLFSDIIRYAVKDFDWEVKIRALQLVETIIQIFAQVRESRNESRHSQQCQLKTLERTSSDNDGSINNLMALLVGLGAAVPLLEAVNDCDSLVCEKALEVISTLKGFVHSEITHTHLSGSSKTGIEFQPYGKENLYGRLDEQPNESKENNQLIVISEEDQPVVTPEQDQPIVTPEQDQPIVTPEQVQPIVTPEQVQPIVTSEQDQPIVTPEQVQPIETQEQVQGVIDTSKVFSVDTFKVILYRLDVSCLSTLCTSIDISVQKDPVGFLEDVLVAARNHSDNLLDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTI9</accession>
    <name>A0A6P8HTI9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melanocortin receptor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116295128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558726.1">
        <property type="nucleotide sequence ID" value="XM_031702866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTI9"/>
    <dbReference type="FunCoup" id="A0A6P8HTI9">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="GeneID" id="116295128"/>
    <dbReference type="KEGG" id="aten:116295128"/>
    <dbReference type="InParanoid" id="A0A6P8HTI9"/>
    <dbReference type="OrthoDB" id="5968553at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004977">
        <property type="term" value="F:melanocortin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001671">
        <property type="entry name" value="Melcrt_ACTH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00534">
        <property type="entry name" value="MCRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031558726.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34735" checksum="673363CA86A8247F" modified="2020-12-02" version="1">MDTNSTNATSSLLGKSCQFSRVASIVFIFLHVLSSVLAITGNSLVLLAVYKSQRLRNVSNFFLCSLGFADFLVGAIMNPLYATFMALFMTSTRLPFFLFKISDFLTCQTLVASTISLCSVSIDRYIAIKWPLRYHLIMSDKKCGMVISCVWLFSIAMGIPQVILSDRRDLKLFGILSSAITAIVPLSVIVFCYVQIVAIAREQSRMLAGSTHGPSHQERIRIRAMKFEKAALTFVLIAGVFVLTFTPHLVLSFVHVFVREDATGCSFHKKYGIWFILLMFSSSFLNPIIYSARSREFRNAFKRLLKLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU42</accession>
    <name>A0A6P8HU42_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair protein XRCC3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116295281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558926.1">
        <property type="nucleotide sequence ID" value="XM_031703066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU42"/>
    <dbReference type="FunCoup" id="A0A6P8HU42">
        <property type="interactions" value="1488"/>
    </dbReference>
    <dbReference type="GeneID" id="116295281"/>
    <dbReference type="KEGG" id="aten:116295281"/>
    <dbReference type="InParanoid" id="A0A6P8HU42"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058766">
        <property type="entry name" value="HHH_XRCC3_RAD51B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26169">
        <property type="entry name" value="HHH_XRCC3_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="71"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031558926.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38000" checksum="8CAB3B2C6C75D0BA" modified="2020-12-02" version="1">MERLDLPQRIINAVKKGKLDNIHTVVCMSATDIQRATRLSLKDIAILHQVAGAAIPRPPVQTALELYHSSNGSYLSTGCPILDKALRGGITCQGITEITGESASGKTQLCLQLCLSVQLPRDCGGLGKGALYICTEDVFPSRRLQQLIPAFLKKQNKKATEHLKPGDNIYIEHAADVEDLRSIIFHRLPLLLNNGKVKLVVVDSVAALFRVEYSQNETFKRAKALMSFGAQLHKISHQYNVAVICVNQVSDVVGNNNASSLGCKGVIPALGLAWSSMVTVRLMLSRTEQFIDVRSIKESSHNNLVKRNLNVIFAPHLSNITWPFIVDTDGVHGLPEEYTTGNNREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV18</accession>
    <name>A0A6P8HV18_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">P53-induced death domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116293181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556437.1">
        <property type="nucleotide sequence ID" value="XM_031700577.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556438.1">
        <property type="nucleotide sequence ID" value="XM_031700578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293181"/>
    <dbReference type="KEGG" id="aten:116293181"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="2">
        <location>
            <begin position="96"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556438.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39457" checksum="DF36B0AB9D73CC69" modified="2020-12-02" version="1">MAGITTSVSYFLXLSSSKXVXLNEPITMTLMHSGPGKEYGYTTTVISFNQDKYVWEXLKATEQESTLGRYRKDYVRVQISKLTILAVVTRLITDRFQVTPKGCVVRSSVCDDVTIEFPQGAVXKTVEGTLKLLLMTQRKYLENDEYGYPCPILLVDGFEGVSLQKPVTIRMPHPCPAKCPVEKVNLMRLPSESETVLENEWEDITDQIIYKEIKTDQKCFVELQVQRFSWLWLWVLSVTLQMYMLQMIVIDLISSPPLFVRVGLFKAKDEHRRPVSMLKALKLTLTCVANHDERYMRKMKESHEELAIATSVSPLRQGDKALVKVGGDFKEKYQRNEQEKVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV55</accession>
    <name>A0A6P8HV55_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Activator 1 subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556560.1">
        <property type="nucleotide sequence ID" value="XM_031700700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HV55"/>
    <dbReference type="FunCoup" id="A0A6P8HV55">
        <property type="interactions" value="1968"/>
    </dbReference>
    <dbReference type="GeneID" id="116293291"/>
    <dbReference type="KEGG" id="aten:116293291"/>
    <dbReference type="InParanoid" id="A0A6P8HV55"/>
    <dbReference type="OrthoDB" id="10254700at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556560.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37350" checksum="7890527D0F57BF81" modified="2020-12-02" version="1">MVVAERKANLPWVEKYRPKCLDDLISHKDIINTIQRFISEDRLPHLLFYGPPGTGKTSTILAVAKQLYPDKEFSSMVLELNASDDRGIGIVRGSILSFASTRTIFKSGFKLVILDEADAMTDDAQNALRRVMEKFTENTRFCLICNYLTKIIPALQSRCTRFRFGPLSSDQMMTRVEHVIESERVNITDDGRQSLVRLAKGDMRRALNILQSTSLAFDVVNEVNVYLCTGQPLRSDISKIVEWMLNEDFATAYNNIMKLKTLKGLALQDILTEVHTYVHRVDFPAKVRIYLLEKMADVEHRLAAGTAEKIQLGSLIAAFQVARDMVQASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVV8</accession>
    <name>A0A6P8HVV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclic AMP-dependent transcription factor ATF-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556775.1">
        <property type="nucleotide sequence ID" value="XM_031700915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVV8"/>
    <dbReference type="FunCoup" id="A0A6P8HVV8">
        <property type="interactions" value="4014"/>
    </dbReference>
    <dbReference type="GeneID" id="116293486"/>
    <dbReference type="KEGG" id="aten:116293486"/>
    <dbReference type="InParanoid" id="A0A6P8HVV8"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000010">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="333"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556775.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="52524" checksum="E214ED10D9A6E9AE" modified="2020-12-02" version="1">MESDDKPFVCSAPNCGQRFANNDHLESHKQKHQLSLKLPGNLKSTDFLQLADQTPTPTRFLENLEKEGLFQDLENPFDQEFKKAAPSNSEEHPPQSVATTTNSTINENSVIIINAPISASKTEIAIPEIPIVAETVVVPAATQPLTTLRDPPPITPKTSNTSAAVSVLVRTTPRHQIPTVIPAAIANANIPVPAALPVPGHLSRTTGQTSMPVSIPTPAIVSSPSASNPPSFIGSAKQRLKEQLRQNHNNNAINNADNIISQAMTEAVDMVTSENRNGLSNHVAHSQIHHHQQQHHFSNGDHWDENDNDNEEMAYGQKDKKRPRRTQEELDPDERRRKFLERNRAAATRCREKRKIWVQQLEKKADDLSDTNTQLQNEISLLKSEVAQLKSLLLAHKDCPVTLAQQNMSVQNPIGQGNVQPRTNGGHVQVTETPNGLALTVTRNEVTPEDVATTALTQMAQRAMGDPYGGQSNWASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYB4</accession>
    <name>A0A6P8HYB4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557607.1">
        <property type="nucleotide sequence ID" value="XM_031701747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294200"/>
    <dbReference type="KEGG" id="aten:116294200"/>
    <dbReference type="InParanoid" id="A0A6P8HYB4"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557607.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13490" checksum="04A331A1A8E36CB1" modified="2020-12-02" version="1">MYDRQVVNIFSQASCCHSDDVVKAWTVCKHDKQFVSLSAKHYVVIVMMLSSSSQQINDRQVSSPILSYSIIPSCKKNEIHLIPPTRSYQHQTXAAPPGQETTKGGTTLLLLAESNLEAMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYE9</accession>
    <name>A0A6P8HYE9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116294232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557647.1">
        <property type="nucleotide sequence ID" value="XM_031701787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYE9"/>
    <dbReference type="GeneID" id="116294232"/>
    <dbReference type="KEGG" id="aten:116294232"/>
    <dbReference type="InParanoid" id="A0A6P8HYE9"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="945"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1170"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1103"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557647.1"/>
        </source>
    </evidence>
    <sequence length="1198" mass="133325" checksum="FE6881721DB5806F" modified="2020-12-02" version="1">MLVLSEEIFTRALGMDDSEAWLHHYMLGKIAEKLRKSPEIYLEHYEKSSRHLDEDIANYPRKIPFYSPPDHVLEALEVYYRVHVSVLKLLLNEFPDVNKEILEKYLQRAAKGPFFSHEYDIDGGHSIAFRSESTASETNAIEPDKGVFELSSEFLASTKIDTSTAPVSQSTVPTAMQVSFDVKQDVRAEKSGLAQAASKDNDDVVSDSQLQGQVQKDKDGLEEPREVTPAMEMTEEKSAAVTSKLLQEQPPHDEKLKKEPSKDVKENIPSSLITEPIESTLRKPQESVIEDDNGNVTKDKSVSNNPFADALTKESKNEEVGKSGSVSESIKQEEEIEEKMEVEEKEALLVASNVAKQPDDTNGLKGTETEVAQPVKSNVSQQISKDDTPGSKPDSHILEVVEGMSGIEDTETCKSKSLSSYDKPNTQKEVAVDVPARTPVLLKGTSEISKEHAYAQDFEMANPTCTPENSKELSMQDVKDFDRVKQIGQEDISKDLLKVKSSKEEMESVDSSKFYPGETEMHEMGVPMDTKKITDEQDEEMENTKVTKRPELSTNISDTVEKLSPAIPMDISQSQPEKEGLKKIHPKDTTLMSNETIHESGVGKEALEDTREISASAEEDKVGESKDILRSQSKDKESVTAPKESREETPLVSNGSNSKRFENDSQIRNVGKESKTDKEESLVTNQCIPAQSIVKDKKPLTDEQKIVQRELIDVCIHGLEHCLLRFPQHHKCRYRLANVYYVSPYHKDLQLSRALLLGGNTGKAKLQRNPHQGLFNEKSKTNMFSAFWRIPEEDIDRPGSFCTHTHKSVDLLLQVLRDVNEWDTLISISNLLHRTPEPGKKYLRDNERHFLSKKACDFSVEIMAKRVESQDAQVEPAVLSQLLFDAYECWKIAQKYEGTAKISENLVVKAFEMYREKVPDITDLQSGGESQPSVLDRAIRFCQQSSKPQTSSTSTTAHQTPADSSVDSQIDNAFGSDDIVMSEPRDVSKTAASKDQPDTTSLQKEAKESNGISGKATKEKEIESEAVAIKNTLSKTNERSVSLTEAPTEPLERFTCSTINTLGSKNVSKETSKETKDVCTTRFNQETSSKDTGSGILTKHLDPNQQQSGIGSTIYTKPSVDIPETFPKAEASPLEIQKAFESDSLISAVAECSQSKVSLTLTAKSLDSALDENAKQESPLSLDKDPSFTEPVSLDDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYZ0</accession>
    <name>A0A6P8HYZ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galectin-3-binding protein A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116294427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557880.1">
        <property type="nucleotide sequence ID" value="XM_031702020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYZ0"/>
    <dbReference type="GeneID" id="116294427"/>
    <dbReference type="KEGG" id="aten:116294427"/>
    <dbReference type="InParanoid" id="A0A6P8HYZ0"/>
    <dbReference type="OrthoDB" id="5985384at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028364914" evidence="6">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557880.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11090" checksum="A39A9A7E207A65D3" modified="2020-12-02" version="1">MKAFFFLVGVLLVVFFAGEVQSSDAVRIQGGGLSGRLQVRHNGVWGTVCDDGWSMTNTHVVCRQLGFDGALSYHNSGGGTGQIWLDDVQCSGSESAIQQCRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ09</accession>
    <name>A0A6P8HZ09_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC116294384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294384</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557842.1">
        <property type="nucleotide sequence ID" value="XM_031701982.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294384"/>
    <dbReference type="KEGG" id="aten:116294384"/>
    <dbReference type="InParanoid" id="A0A6P8HZ09"/>
    <dbReference type="OrthoDB" id="6624490at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027695333" evidence="10">
        <location>
            <begin position="17"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="244"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="340"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="666"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="773"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1005"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="1225"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557842.1"/>
        </source>
    </evidence>
    <sequence length="1322" mass="148034" checksum="AF0F9B3337176DEF" modified="2020-12-02" version="1">MLRFLVLVVLFRLSECRVRLAGGSSSSEGRVEIFHNGRWGTICDDNWDIDDARVVCRSLGLPDAIGATTLANFGQGSGEILLDEVQCRGNELSLSDCRRDGWGENNCGHGEDAGVVCGHPDVVNINVSSLSGVIRSPGYPQHMQRANYEWTFRPPIPNPNVIVCFDDLDLRTYSDGSFRATVQDSSNTELFFLKNSKHKGVCVIIESAGGKVIFYASLTPPKDDRGRGFRMRYAAIDRSQAEGFCSNGWDVSAKGEAGRIDLSWKTPPKQSKSGYKYIVVYNSSASNVRANLASSTSVVIDNLNPSREYSIRVIAIPLTNEQSSVLYSCTKRIRTKKEQSRVTDGKSASEGYVQVYHAGQWTRVCGNYWWDINDANVACRSMGLVAAKHAMVTYPKITKKGQHILLGNSISKLWLSGLRCTGREKSLLGCRTIASLGWTKFCYNDAGLVCKTRRAPQVERRNITDQAGFIISPGYPYSMIQAHHEWTFIPANQNTKVLMEFLHVDLKTKSGLTKLIVKNREGKTLLYAVDQNLPTSPAKRLVVDKFPINMTYVSSFTTDKEGKGMRMRYVFFDDSCSSNWSINVKPGNGKMNVSWTPQSSDSEYNYLIVYNSTFYKSDIVEILSPGATIDYLPPNTVYRVTILALHKNNTVTKHCTRYVRTKPETLRIGGGRIPNEGQVEIYSYNKWGVVCGYDWDMDDATVACRQAGFPPPTAVFGVGASPFATKKKQTYVLEALQCKGYETSLLECSTKKPKYDCKRANPAGVVCGRPKECKAVVKDRQGTIRSERYFSTREMDCQWTISAPSKTSLIILSLRTIHLSPLAICRKSSLFYIDSNGKTVQQICTSISNEFVMIGFAKIRLFVKRFFIPANMELDYFVSNDKLEDIVEVPNWYITAKSEKAGMIRITWPYYKPVVRDKYQNKKKILDFVPVCVRQKDGLVISPDSRGFHGDFFAIFKNLKYGDYTVYVMAYLGDSLDTPMTNWKEDARRSRNITLRTKQGRPLRAPINVTATTTGTNSILVTWEPIPEEYVNGILTGYTVYIDYYSPNRGKVTDTLGTSVYGRNNTSFKLAMAFSKTKYTFRVKGIAGGGSGPASSKVSATTGYEVWVTARYGHFLASNDSLYTSNTHKTWKLCPQKGRVDEIFIVFKTFDLESSHMCSNDYVKVTDEYDKKFGGRFCGKKSAFAVSVMSKRVAHVTFHSNAAIEKSGFSAFYKVIDQRLSKKSSVWNLQVQNASRTGAEVSWDIPDGNVSDIMVLFKESSVQYIWQAVKASPLDNSILLKELVPAKQYHVRLVGSIFDVIQESKLMTFTTMGGAKLDAEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ88</accession>
    <name>A0A6P8HZ88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhodopsin, GQ-coupled-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557927.1">
        <property type="nucleotide sequence ID" value="XM_031702067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ88"/>
    <dbReference type="GeneID" id="116294469"/>
    <dbReference type="KEGG" id="aten:116294469"/>
    <dbReference type="InParanoid" id="A0A6P8HZ88"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557927.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41287" checksum="627376FEEEC01BD1" modified="2020-12-02" version="1">MMNVAGNGSVFETRVIYSEIESAFQATSLIIIMGVAILTNIFNITVVYLNYSMQTPRYMFIINLAGGDLGVALLSMPFCLVTSIARDWVFGSAFCQLHGFLGSLFFCVSIFTLTIMSIEQYHALVKPLSRAINIRRAWYMIALVWSLSVLVSIQPIFGWGHFSFNSSTLACGVSFPKRVTERLYLLLLVLLAFVTPLLIMGYAYIRIFIAVQKHSIRIAQYTKGGQEVIRLQRRITFTLLLVLIVFLLCWMPFVILIVLASSRQDVLQLPWGLGVAAYWCGFFNSALNPIIFVIRNDKFREGYIEILSCLWGCIRCRDIIVLKKGRRRSWQLSRSMKRARPSIVLGSVKRFAPPQELVNEEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZS8</accession>
    <name>A0A6P8HZS8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558112.1">
        <property type="nucleotide sequence ID" value="XM_031702252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZS8"/>
    <dbReference type="GeneID" id="116294615"/>
    <dbReference type="KEGG" id="aten:116294615"/>
    <dbReference type="InParanoid" id="A0A6P8HZS8"/>
    <dbReference type="OrthoDB" id="5948547at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558112.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26638" checksum="5865DED1A07B4AE7" modified="2020-12-02" version="1">MASVTSIRSCVDQENSQQALRVKNGVQARSFGQVKSFNSTGNNAPLATPRRALGDVGNTLMTPGNVTKKSSLLKPSHQNNLLQSKTPGAKKMTHSTPHGKALSKQIGSLSLKQNKKQAFKVRGDVSTSDKSSALVEKNYFKKENMVPFTDEEGPLPRGPAIDTILKNVSQLYRGCLQPVTNPGVSLESDVLKTGDDAYTRPETDLFFNWFEFANDLSDLTSNVPSSSMENVELPPIDTDLSGLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I028</accession>
    <name>A0A6P8I028_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 31-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560881.1">
        <property type="nucleotide sequence ID" value="XM_031705021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I028"/>
    <dbReference type="FunCoup" id="A0A6P8I028">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="GeneID" id="116296911"/>
    <dbReference type="KEGG" id="aten:116296911"/>
    <dbReference type="InParanoid" id="A0A6P8I028"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040066">
        <property type="entry name" value="WDR31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869">
        <property type="entry name" value="SPERMATID WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560881.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40221" checksum="733C72773D0786F5" modified="2020-12-02" version="1">MPAGCFDCFEGVLMGLRKSKPHNNRHYHGDDGLIDVISTHQVVDYDAVHRDAVTCVTAYSEAFCLSGSADRTLALFNLRSGVMTQRWRGHDKEITKVVVSKEEIVYSSSRDKNIKLWKIGDGSSSEITTYEGHKLVVTGIDLNTDETMLFSGSRDNSVRLWDVNVGDCIQQSEVTRNLVSCVKWIPDSHEVAQTGEDKMVRIWDTRTMTPAFTFPPKQHFQTCCDCSSDGRYILTCNNGFNRSGCEATLWDVRQRKQVHQYVGHDQTASACMFLPFADDITTQPLIATASHDSTVRIWKRDTKECILIEEFPGSGPLTGLAAFKSGSILVSSFNIGIYNLSLERRDDGRLTLKRMIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I196</accession>
    <name>A0A6P8I196_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Protein MTSS 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116298125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562354.1">
        <property type="nucleotide sequence ID" value="XM_031706494.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562356.1">
        <property type="nucleotide sequence ID" value="XM_031706496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298125"/>
    <dbReference type="KEGG" id="aten:116298125"/>
    <dbReference type="OrthoDB" id="10061327at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF4">
        <property type="entry name" value="FI21477P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031562356.1"/>
        </source>
    </evidence>
    <sequence length="651" mass="70756" checksum="87EE4C68054448B7" modified="2020-12-02" version="1">MTEQLEATEGNLIQHIINDLKSSGPVWDDFVAKAGKLHSALRATASAADTFLDAFQRVADVANSSRGSSRDIGASLTKMVLRHKCIEGKLKALIGLLYDSLISPLQSSLDEWKRGVNQLDRDHTKEYKKCKQEMKKITAETIKWQKKVKKGKTENQERLDAAVKQANIQLAAFEDQERKYLRKVLIEERSRYCTMASCVKTVVEQEVSMLSEIEHLESLLADIVKQTYNPAALPVVGEDLVRNLRLSDXSSGSWDDEQTPPPSPTNSAVRTPAHPTALQLSTSPVHSNIRDPPTTPPPPPPSEKDAYYDAFSRHYSFSAKHSSNKGRVQRPKLIPATPQASPKKHHTSMRSSSFSISSNSSYSSMSSLGSSLGSPSTESLPHPPPPLPAQHAAGSVDHLPPPPFPXVPVAQDQAGHPQNDRSSWMTADSGCCSSSSGERSPSTSMGQVYCPTVPEYPPEETTISGHQYATPFATSSRNRCMSESASSNLQGRVHRKSDSEASSQSSYYSGGSDVTSIVSSDSGYFGQGHPHPEWHQENSAPTSTSPPKQRSAFNRSQSVSGRPSAAQAAQLAVLASHAARSRSAPMPPVRKSSVPPPCPERFASLLKEEQANEDAQEDNGDKPSLLLKQIQMQRQAIKSKSKPTTGAVNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I250</accession>
    <name>A0A6P8I250_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Betaine--homocysteine S-methyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561616.1">
        <property type="nucleotide sequence ID" value="XM_031705756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297515"/>
    <dbReference type="KEGG" id="aten:116297515"/>
    <dbReference type="InParanoid" id="A0A6P8I250"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051524">
        <property type="entry name" value="BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120">
        <property type="entry name" value="BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46120:SF1">
        <property type="entry name" value="HCY-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="8">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031561616.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30029" checksum="21A1CE1E9802B7E8" modified="2020-12-02" version="1">MSKPRGLLERLDAGEVIVGDGGFLFCLEKRGYVKAGPWTPEATVEHPEAVRQLHREFLRAGADVMHTFTFYASEDKLKNRGNDAIKIGCEAINQAACDLAREVANEGGALVAGNICLTTSYFSGKGKEACQAEYKKQLDVFVKNDVDFLIGELFSEVEEAEWATEVMKATGKPVVCCLTISASGDXXGVSXKXCTLRLAKAGADVIXVNCXFDPDVCIEIVRLMKAALDEAGIKKHLIIQPIGFKTPEYLGGXXXCDFTDFPEFPFGNITFNIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2E8</accession>
    <name>A0A6P8I2E8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Perlucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561983.1">
        <property type="nucleotide sequence ID" value="XM_031706123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2E8"/>
    <dbReference type="GeneID" id="116297820"/>
    <dbReference type="KEGG" id="aten:116297820"/>
    <dbReference type="InParanoid" id="A0A6P8I2E8"/>
    <dbReference type="OrthoDB" id="5973476at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="102"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561983.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25693" checksum="EEE9EC1DE6C4D7DD" modified="2020-12-02" version="1">MGIPSTKWPLRNWQTLTASLQHTRPALAYGVPCPERTVSTISFGCFSAFKCFSRFSFSFIPRPPPETPCEEKPCKHQDKCIPFYTNNTYKCIPGCGQGWLQFDNNCYFFNHDPSKPAHWNDAANVCQLLGGHLVDIRNEYEWQFVKSNLKRAGDAYAQYIIGMTDAASEGHWKYTDGTAASFFKWNAGEPSGGTSENCGSIFSDANIGSYNDGSCTYNYGRFICKKGAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3V1</accession>
    <name>A0A6P8I3V1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pleckstrin homology domain-containing family M member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116298293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562548.1">
        <property type="nucleotide sequence ID" value="XM_031706688.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I3V1">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="GeneID" id="116298293"/>
    <dbReference type="KEGG" id="aten:116298293"/>
    <dbReference type="InParanoid" id="A0A6P8I3V1"/>
    <dbReference type="OrthoDB" id="9983817at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17680">
        <property type="entry name" value="RUN_PLEKHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000004">
        <property type="entry name" value="pleckstrin homology domain-containing family M member 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053015">
        <property type="entry name" value="PH_domain-containing_M2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057288">
        <property type="entry name" value="PH_PLEKHM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047327">
        <property type="entry name" value="RUN_PLEKHM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46556">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46556:SF1">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23142">
        <property type="entry name" value="PH_PLEKHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="736"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031562548.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="87162" checksum="35F1B1B026D5C875" modified="2020-12-02" version="1">MFSSRSKSAIVKDGIIEQIGEQIKALQISKQNADAEGDTNYRVTSRNIHLQCLLDLLDHVLLHGLVNVENGYWPFVVKITHSETVKLISRHPQVSNDLDKGRVWVFVAVCEGLLESYIRLFMEGQKDAKKLYTKDAFVRDKERLVILLTLVSGLDYVPIALDMSSPYLGYGCLPAPLTKASSSSPRTVVKNGSKQGHSRESSVSTSSSVSSSSTLHAPTSPXCLHSNDTETFELHDRNETSNNFKEFQANGLQNFKVDLELRKVEFNQANDLYHDKEQAKDMASKHFDTITKPFWRAVGKPVQTNQSGNTKPXGTDKSTGTKPADSDQSTKTKPVASDQSETKVLGLMDPHLSSLDEDLSXDFRTRLGSNLSEISMEDMDLVVQHEHIKTRRVMRKXPRPQRTEKDEQKAXKYPSPEDHKDEHDEQDEDNEGLDVPKLYARTSSYLSDYRNDSESAASSVVSGDSLDQFCRDADFGSLNNLSSESAVHTVVTECKNEQTDLIKKEKEHEEKPKAEQKEKTGSEDAVTTSSEYEGIILGLPKRPSLRDIPGNSCDVRTDANTILLLSLEIFKNSDEQFHRMLCTSTGHHFGQLLCAYVLLTDFAMYLIRKVSFRKETSFHTDVAIEFANIKSIEIGLNCQSVTVASKKEHCTITFADEAVSRSFISSLTSQVSRCCPSMSLSNLVSNTALQQESAIVKWMAKDKKLKMTTQNTSCFSLVRWCGLTGLDSKIEILSFQSVMEGTLDYKQQNYLRISSKWTKGYFVLTNGTLWQYSNQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3Y2</accession>
    <name>A0A6P8I3Y2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Retinoid-inducible serine carboxypeptidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Serine carboxypeptidase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559505.1">
        <property type="nucleotide sequence ID" value="XM_031703645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3Y2"/>
    <dbReference type="FunCoup" id="A0A6P8I3Y2">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="GeneID" id="116295736"/>
    <dbReference type="KEGG" id="aten:116295736"/>
    <dbReference type="InParanoid" id="A0A6P8I3Y2"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028410718" description="Retinoid-inducible serine carboxypeptidase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559505.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49621" checksum="3CB3894CC13485F3" modified="2020-12-02" version="1">MASVLTLSFIFVVLSAICLTSTQAKRFKADIPDEKWNYVKVRDNAFMFWWLYGAEGDPSQRATKPLIMWLQGGPGGSSTGYGNFEELGPLDVNLKPRNTSWTSVANVLFVDNPVGSGFSYVTDKSAYTTNVSGIADDLLTMFKSFLDTMPVFQNVPFYIFCESYGGKMTSAFGVTLYKAIIAREIKCDFKGVALGDSWISPIDSVLTWGPYLYSVSLLDEDSLAKVNALANATAKAVAMKQYQEATNLWSQTEGMIAKTTDNVDVYNILLHNAPPFAMMLQSLGDRNLDRLYATHVGRLYTESLSDLMNGPIRKKLGIIPPNVTWGGQSGEVFIYQSIDFMKPVIQDVALLLSGGLQVVIYQGQLDMICDTPGAEEWIKKLDWSFLPEFLKSPRVPLYPPSGVKTKNTGAFLKKYANLELYYILKAGHMVPADAGEMALEMVKRVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4S1</accession>
    <name>A0A6P8I4S1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116298222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562466.1">
        <property type="nucleotide sequence ID" value="XM_031706606.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116298222"/>
    <dbReference type="InParanoid" id="A0A6P8I4S1"/>
    <dbReference type="OrthoDB" id="5959886at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028339991" evidence="8">
        <location>
            <begin position="28"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="10">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="612"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="880"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="12">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031562466.1"/>
        </source>
    </evidence>
    <sequence length="915" mass="102969" checksum="3DB72584293F49C4" modified="2020-12-02" version="1">MASMKIYRVTKQLILLGAVLLVRSVDGSSNFSRAAAISSGXSYDARTSSKKCSSVYSCQGRCSTKTEWDTGKEERSIAPHCHCDPACNKYQDCCADYRKACGNQSLPSXSSDDPVFVCRLLNIAEPSMWMVESCPSSYKNKEIRDKCLSNESLRADRLGEMIPVQHLDKSGLIFKNKFCAMCHGANTDFGLFPSQIRIRCNILPPKDSNSTLDLEYILKYCGNIDFEIDKSYQRRFCFPTKNKCPSGASKEDEEGCESGPTAVVFSSEADRNYRNVHCMACHGLNPNDAMCGPRSTPKDVFTPKSFEVVMNFKHDDAGKAQLTKPKNLIKCLKGEAFDKHLEICRPAMQPGPTKSIKDKYRVMMWLFPVNGQQPQNISHTDFVDTLXTEFVGLLPSQVEVSSIKIEDRTIRAVFDLHARYTNNSKENSNSSKGMQLDALINFKNQFKMEVAQRLWLVLKVTTRRLSCVQREVYPSGTYRIIPHNERIIVNSTNGTQVSYSVKQYYLVGVKEAKNLTFANATAIVCRSYFGFQCDKVMLAVKEDEYVMFKNKTLLFKPTGQQYAEGEYDMVKNTPWICTNYSVTFTTNNTSSKTNETLIKSKLLPVSIHTNIRRYMTIVGFTISILCLFLVLLAHGILRDLREPLPGKNLISLSVSLFLAQFWYLLGSGDTDKPLFCHITACILHYLFLASFGCTFIVAYDTRRTFSATTAKAHALGSSHQSRRLAIYLLISWGLPLVVVGTCXLLDWLDVVTIGYRNENACWIGNETALLIVFAAPIGSVLVYNVLAFTQTIYAINSARKQTQQVKSSHYARPATVKIYIRLISLMGFSWFFGISAPLIHHGLMYPFVFFTTLQGLYIFLAFICKXRVLRMLKAKLPLNKGKRSRRPTKGATTTTSSLTSAPYSKYPRPSDETQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I520</accession>
    <name>A0A6P8I520_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296037</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559860.1">
        <property type="nucleotide sequence ID" value="XM_031704000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I520"/>
    <dbReference type="GeneID" id="116296037"/>
    <dbReference type="KEGG" id="aten:116296037"/>
    <dbReference type="InParanoid" id="A0A6P8I520"/>
    <dbReference type="OrthoDB" id="5964497at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559860.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="61402" checksum="33DB195607E19AC8" modified="2020-12-02" version="1">MLMEEGYAWSAAVWINDHILELGLTAFYSLCILTIFAVINKRFLLKKRQEDKEKPTELPQESNGRKLCRIESSVDHLHKYGGSIGAYVLLLNSKVYLNPNMVKNALVYLTNRHEILRIKISRKKTKIQGNKKIIKEFKAMENSDFAEFLLKLKATTSDQWLSVFERELMKQFPEEGPLWRFVMLKEQFHPKEGVYSNAFVFSAHHLVCDFESGFNFFSDFLDYLNSSIQDSSLSKPDFDVKFPLQLSFSHLLGNCMSMSQPLIAVTAAKVFVMKMIEKIRPKPTYKNPFTSTFHPTITKNPTIQKKTCLIPRSLTKEETLNLIKLCKANKCTVYGAVSAATTIAMATILRKGKSTAPLIITSSFQVDLRKDCNPKVEPQELGHYSMNCSVNVPLAKDITLPLGVNDASFWLLAQECDRIFHTAITNNDHLNSMKLMTNLNINPLRNLGELAKDQEAAGRQASLFHLSNLGKKSIVNSDAINLEGFYFALAEHNIGPVFSNNIASVNGVLYWGFTYFTNVTTESQAVEYADLVMNCIKGNSVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I592</accession>
    <name>A0A6P8I592_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 66-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116296112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559930.1">
        <property type="nucleotide sequence ID" value="XM_031704070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I592"/>
    <dbReference type="GeneID" id="116296112"/>
    <dbReference type="KEGG" id="aten:116296112"/>
    <dbReference type="InParanoid" id="A0A6P8I592"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031559930.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19295" checksum="9EDF51693EBA0A6D" modified="2020-12-02" version="1">MMNELVLHEAASTGAYQDLQTMLMLGHIDPNYMDEDFGDRTALHWACTKGHAKCVKLLLEYGADPAARMVGGWTPAHCAAETGKYTVLKILVDHNAPVTLPDDYGDTPRRVTEIYGHTQCVELLKSAEETCEQKKHEVKEKFRSQTRKISRMLGEKKQEEEQTDKTTKGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5P1</accession>
    <name>A0A6P8I5P1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aminopeptidase NAALADL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">N-acetylated-alpha-linked acidic dipeptidase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116299362</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563879.1">
        <property type="nucleotide sequence ID" value="XM_031708019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299362"/>
    <dbReference type="KEGG" id="aten:116299362"/>
    <dbReference type="InParanoid" id="A0A6P8I5P1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000001">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000045">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="18">
        <location>
            <begin position="189"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="20">
        <location>
            <begin position="370"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="19">
        <location>
            <begin position="637"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059290"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068168"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02225"/>
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        <source>
            <dbReference type="Pfam" id="PF04253"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04389"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031563879.1"/>
        </source>
    </evidence>
    <sequence length="758" mass="85828" checksum="92E95D5898A58E6B" modified="2020-12-02" version="1">MVETAEKAEETEPFRQKEEVEYHPANSKAEQEPLEDQRLRIRVVILVAAVLVLIGAAFTVGYVVRRCGRRPHPIDIDELARDAIENISTSNIQDQLRYFTRTPHLGGSKESKEQAEYIQKEWQNYGLDRVELKKYDVVFSLPQKPGLARIVNVNGTEIFQASQKETLLDGEKDXRILSPFNAFSGSDNVTAPLAFVNYARLEDFQKLKELGXSVAGHIVIAKYGKIFRGDKEKLAREAGAVGLILYTDPKDYSPGVSRNHTYPKTWWLPSSGVQSGTLFVGDGDLETPGYPSIDGMYRSPINESQLPKLPVYPVSSDDAKHFLGLLTKNKAPADWQGGLPTTYNINMASSNNTKVKLDVHMEYVTKSVYNVMGXLKGENEPDRMVLFGNHRDATAFGATNPSSGTAVLMETVRVIGRLHKKKKWRPRRTMVFISWGGEEPGAIGSTEWVEDFTNLIKNRAVAYLNVDAAVEGNYTFRTASSPLIDYVMFEAAKNVFTPNGSILDYVYHDWKVKRPDKNNPSIPHTSKLTSSSNYKDFYERLGIPSVDFGYTWNKAKMNISTYPVYHTVYDTFHYMANFVDRGFHYHRTVAQVWVRLGLFLSESLIVPFNCSRYAERIASHVKDLKKVHGAKLVNHLKLDQLDNAVKNLTAAAKEFHRFSSSLNYQNALPVTIRMANDRLVHFEKSFINPQGIPRKPFRRHMIYATNAVDKYSGLSFPGLVDSIYEAKTVKDWHEVNKQLSLLVYYIRSATQILTTQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7J7</accession>
    <name>A0A6P8I7J7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116299449</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Deltex family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031563968.1">
        <property type="nucleotide sequence ID" value="XM_031708108.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299449"/>
    <dbReference type="InParanoid" id="A0A6P8I7J7"/>
    <dbReference type="OrthoDB" id="5974467at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="15">
        <location>
            <begin position="357"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="1435"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="694"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="899"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1118"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1157"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1195"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1243"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1265"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1278"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1323"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="17">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="17">
        <location>
            <position position="1356"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="17">
        <location>
            <position position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031563968.1"/>
        </source>
    </evidence>
    <sequence length="1628" mass="179180" checksum="1E67267DF23FDE11" modified="2020-12-02" version="1">MASRKSPDIPFAGEPDTGLDETQRKKSVLITNVPPGTKEXDXIIHFQKXSNGGGEVEDAKMXEDGKAXVIFDEEEVANRVLEREHTLNGNLLQLEPCFKFTDDMEVFSLVSAKLDPSRFTVDLKELNELLVKAQEETGVNFLETCEGFLVSGTLEQIEKSCLFLSRYAKRATPVTENSDNLQXVHRNDHPLSDSDDXENALKTLVLDVEPKLMQILQIKVNEIEKKFKMKIDWKSEPGKAHLSPNGKDAKLFEDGKEEFITLYQKEFPDLQEKDFPLDAGKSIEDIDSTVKALMEEFAVVIERKDDKNVHIFGKENDVAQVMQQLQGKFGKRRGRKLYKASSNGELPMPDTYAQAAMLPLSKTLDNGVVVSVHQGDITRVLVDVIVNAANESLAHGGGVAGAIVKQGGQRIQQESDALVRRYGCVPVGRVAYTGPGNLPYKRIYHAVGPQWRVHGEERSRHFIYEACMNSFEQASKHRMASIALPGISSGIYGVPKHVCAEMMFAAAESFAADASSDNQLKDIRFVNIDTPTYEAFQREFHNRYSLMTKKDADLGSNLKDEDALGLYPQAGKERKYKRNTNQQMFDSTGRTDQVDSIEERERIKRAAAAADAAARRMEREENVEKQNNNENENKVCPKNNMQNQSIESQPEQDVIVLLEKLEINDDHSKREDTGKMETNENNTPEIINVKEKEKVSNITKSMDTDTDIEDADGKKAVPEILNEADESSRLKERPCEQSYSEINNKSPGDGIKASDRELSGKGAKKTSKLCGRGRGALAFTPTLTGTMPGRAVRQDPYNVNGDSRTDEDEPSEGDCKVPPGLKVSEEGLKLANTTRKRSEERKLSQEEDSVNARKKHLESEPKDTIDGVPPKKAKVDERTEEKEGGGSAKHGDTMTNINEKYEDPANGKSERDDDKEEVKEEIKTDMSGSDESYASKEDSNSNKENNEHDIVYKSENVCDQEKKEIKSKDDHLNNNQTEKISGMHAEKEEESSATSGGTTDSKEPMDSKLKSDGDGQSSDHYAKQEISAVXENATGPKPLYPNAEENGDDQNIHKDAKEEIIDASAKATELKNLLDSNVEDSADDQNSQKDSKDESXVASSTKADDPKEQVDSNVEDYGSDRNSHKDSKDERSVASAEAAEPKTQTDSNVEENGNDQNSHKDSKDESSIVSEEATEPNNPLDPNVKRGSESQAPDLEAKNNSKDVSSEAADPKKPLERDGDGESSNKKAEEESNTESAEAIDPNNVSNFSAEPDSMNSFVLLDMPSVDHDSSIRPEKTSXSSDESSESIELLNSEGDGFSDTSSSSPVIEQGSDLAKPSGGDLDNSNTLSNTLYEVNPISDSHTKATGXTVGSAVXDNKDQSXENNATELEGGAGSXSXHQEADNTESIIKDNDHPKKISSVEXLSHDNVAADTVKKAVNSDSETTSAISNEKQECGVCLSTLDSAQLLRICDSGHAVCRNCFDNLQNAELNSVCPTCHKVVPRIALQPPNGQMKSGIIEKGLVGYESCSTIYVDYEFPEGTQGPFHPNPGTPYDKLSRRTFLPDNEEGRXVLDLLKKAFDASILFTVGKSTINDKDNQIIFNGDIDHKTNVNGGPKVSGYPDPDYLDRVKKQLNAKGIESISQRPPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I868</accession>
    <name>A0A6P8I868_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain collagen C4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564238.1">
        <property type="nucleotide sequence ID" value="XM_031708378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299670"/>
    <dbReference type="KEGG" id="aten:116299670"/>
    <dbReference type="InParanoid" id="A0A6P8I868"/>
    <dbReference type="OrthoDB" id="6086925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027881287" evidence="2">
        <location>
            <begin position="24"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564238.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="31936" checksum="66F36EACE1B37141" modified="2020-12-02" version="1">MALCKMLVVVLVVFILLAVCDEAGSMQGQDDDVSLEKRIQAQSKSLTDILTLLKQLQKRVHQLESRRIHFLRGRDGRDGLPGSPGPTGTTGRPGSNGQRGPPGPKGDRGPGGVAYVRWGKTTCRWGASLVYKGRIGGEHYTHTGGGTNYVCLPETPRYVRYTSGHQEAGYMYGAEYERQNKNPLTKTNLYHRGAPCAVCHXSTRSAKMMIPATYACPAGWTREYWGYLMTEHYSQKHPTEFICVDKDAEYVSGSSTGHHGALLYPVEGRCGLLPCSSYVDGLELTCTVCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8R1</accession>
    <name>A0A6P8I8R1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116297048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561045.1">
        <property type="nucleotide sequence ID" value="XM_031705185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8R1"/>
    <dbReference type="GeneID" id="116297048"/>
    <dbReference type="KEGG" id="aten:116297048"/>
    <dbReference type="InParanoid" id="A0A6P8I8R1"/>
    <dbReference type="OrthoDB" id="5986008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028386880" evidence="6">
        <location>
            <begin position="20"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="672"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561045.1"/>
        </source>
    </evidence>
    <sequence length="796" mass="90566" checksum="2CC9A82ED954B51A" modified="2020-12-02" version="1">MALSPILPLLVVLFGVVRCAVYDDVATVTKARCYANCITQVSKYAEPDPGCLGNACKQCLLPCDRKWTNIEDCKETCEISKICRRSCEFLGYLKGLPNILDGDLTLTKHPGVPMATEKTVQNLTLSWTPATSYVGSVVYLLKKMFQGDFSDLNLKDLKDVVFTQPRAVLDVTDVCRYAPRYRWKFDGVQFKFQVIALTEYSKLIGSAKSNSIEMTRPEPVSAVGTPSFTYDADAFGDKLKMTTTVIPLQAQVHLISQYAVDWSMAFCSKEPFVVPRSSTSEKANTTVSVQLYEKLKACNHTLKVYSLNQCIPSKPKILTYKYKGCRFVSNFKRSLCYSFDPPPTPDSARQVVSLAYSPFTYSNDFRFSTKVTWSPPTFSFGKVERYIFAYGDVNKKFMGIIWIAKRGSTKNTFLKATNLEPNITVRFEIRPRFPNAEGVVREIIFQTPGILEDKIKVQNLKADQVSFSDTSLFSFRVHWEKPVSHSQLDGYQIDFIKGSNAQKTVKTSDRFYVFRGLLHNEPLVIEVKPLYKVKWIKPKYVVLRLKAPAPSNKDIAVKRLSNFNFTFDPQTTTFTSYFEWNPPSYSYKTVDYYEVGYSIIDAHGKLIITCPTSYANKAKLCMPATTKENRYSIPRVHPHMHIVITVKPVFQHSPFLEGIKVTYTVDVPYGPVSFCDGKPEGYHADVEDCTGFYKCDANGETFRMFCPEGLYWDNDTQTCDLRSSVNCQKNNLSCCQGRPAGYYSIRHNSASYCVCDGQGRGFLRMCTSGLHWNEQRRACDFPKFRGHRHYQDINHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8R6</accession>
    <name>A0A6P8I8R6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116297051</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116297051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561050.1">
        <property type="nucleotide sequence ID" value="XM_031705190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8R6"/>
    <dbReference type="GeneID" id="116297051"/>
    <dbReference type="KEGG" id="aten:116297051"/>
    <dbReference type="InParanoid" id="A0A6P8I8R6"/>
    <dbReference type="OrthoDB" id="5959805at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031561050.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15133" checksum="DAF6E7A90CFF92A4" modified="2020-12-02" version="1">RQTLSRMQSIKSHSTHWRATCSYPAHGVDYRDYVRGNFKDFDIMTFLGGGVCKKVEYINIRGHIGIHTTSKWWQQRNINTLHVDSGNSGCGFVPVAGSASSEDNFGYYDFSNPNFRCTANDKSTTQWWFGGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8Y2</accession>
    <name>A0A6P8I8Y2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564528.1">
        <property type="nucleotide sequence ID" value="XM_031708668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8Y2"/>
    <dbReference type="GeneID" id="116299941"/>
    <dbReference type="KEGG" id="aten:116299941"/>
    <dbReference type="InParanoid" id="A0A6P8I8Y2"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="643"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564528.1"/>
        </source>
    </evidence>
    <sequence length="856" mass="97688" checksum="331F4EE521D325C7" modified="2020-12-02" version="1">MENDLKSNAEECNETNDSGQNGTAITLSKYHEANIKYHEKQVTIALEKGDKMMEKTAYRNLGTIYRSLGKYEEAVENYEKCLITAIEVSDNRGKGKDLGNLGAVNIEMEKYKKGIDYFKVQLTIAIEMKDRRSKERAISSLANAYQLSGKYNEAVKYHKMCLSTAVRNANKEMEGKIYEDLGFAYQKMRKYDEATGSYEGALCIYKGIREEYGQERMNKNLGSLCQKIGKYKEAINYYKKVLRVVKKRYDTKRERELYENLGNAFQSLGEYNRAILYHGESLRIAVKENDEDSEGSAYENLGNSYRSLGRYKEALKYYEMFLAVCKEKESKKDEGRAYACLGSATYLLAKQNNSSSTSIVKENNKKERNKRKGKPLEETSSSSSAERYSNAIDYYKTSLAIAEEVGDKRSKTNAYGNIGLAYHALGNHDEAIKNFEKELELAREIRDKKAESRACANLGAACQSSGNFRETIQYYKMFLKLVSGDMRKEATAYQNIGVAHQHLGRYKIAFKYHKKHLSIAKQIVDRKDSSNGDATPYEADTNAMGTSSIAAKHLDKKSEEEAYRNLGIACQSLGKYLEAIDYHQKQMKIAKQIRDEEGKENAYRELANANQSYGKYDEAIKHRKMYLSIVKQNNNKIDEKMNGEVYEDLGVAHEAITNLPEAIACYKDALRMYEEIGDKVGQRRIVKKLGSLHQKAGKYEEAVLYYTTGLEIVKEMCDKETEEELYGYLGVLYQCMKKYEDAIICHEKSLEIAKNEECDVAQACAYDNLGNVHKCLGKYSEALGFYKKHLNIAEKNGNIKAQGHALENLGNVCCLLERYHDAVRHHKNHLRITIRIGDKKGQLRAKRNLDNVYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA25</accession>
    <name>A0A6P8IA25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564011.1">
        <property type="nucleotide sequence ID" value="XM_031708151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299490"/>
    <dbReference type="KEGG" id="aten:116299490"/>
    <dbReference type="InParanoid" id="A0A6P8IA25"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564011.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="59222" checksum="BC22F06FD4C2D3A4" modified="2020-12-02" version="1">MAGEKKAKIFNDPVHGHVEMPELCVKIIDTPQFQRLRYIKQLGGCYFVYPGAAHNRFEHSIGTAHLAGVLAESLKSRQDWQEELDITEKDVLCVKIAGLCHDLGHGPFSHLFDRSFIPKVAKKADKDWKHEKASLLMVDLIYTKLKSDFEKHGLEDKDVVFIKELINGPTEGSKEDWPYKGREKDKRFLYQIVSNKDSGIDVDKWDYFARDCYHLGMKSSFDHMRCIKMARAIQVKDDNNKWHICFRDKEVHNIYEMFHVRSILHRRAYQHKTSNAVELMITDALVKAYPYLDFEGKDGKNLKXPEAIHDMVAYTKITDQVYHQILHTSDPRLEEAKQILERIERRELYRSIEEHTTEKDMSRIDVDEGTLEIANKSGVAKEDFILDKVKFDYGKKKENPVKNVYFYKKEDPDKAIKIEEDKVSYMLPEVFLEWKIRLYIRKTELDEDKKKQLIKGFGEWFKKVTDVKEESAAGSSGAAGREDETPEKKLSPEAHDGAPAKKKLEYSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBZ9</accession>
    <name>A0A6P8IBZ9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116300256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>isopentenyl phosphate + ATP = isopentenyl diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031564941.1">
        <property type="nucleotide sequence ID" value="XM_031709081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBZ9"/>
    <dbReference type="GeneID" id="116300256"/>
    <dbReference type="KEGG" id="aten:116300256"/>
    <dbReference type="InParanoid" id="A0A6P8IBZ9"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040647">
        <property type="entry name" value="IPPK_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="ISOPENTENYL PHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031564941.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="29222" checksum="9CBE53922308381D" modified="2020-12-02" version="1">MSANNGVEVIIKLGGSAITYKNELEKENLVAFAKAARIAAGLKGTCIIVHGAGSFGHFQAHEYGVAKGFGCDVDHTRIGFAMTRLSVTKLNHKVTEFFVSQGIPAIGLSPCGTWLTSSGHVTTAVVDNLAKLVFAGFVPVLHGDCVLDTDQGCAILSGDKIIERLVQELQPKRVVFLTDVKGIYDRPPEEQGAVLLQQINVTKDGDISVPIATNILGHDVTDGVKGKLKSISNIVISSNGLTKVFVANILSDSAYRTCIEGCTSQGEGTEIKLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICE2</accession>
    <name>A0A6P8ICE2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fanconi anemia group D2 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116298354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562635.1">
        <property type="nucleotide sequence ID" value="XM_031706775.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ICE2">
        <property type="interactions" value="2763"/>
    </dbReference>
    <dbReference type="GeneID" id="116298354"/>
    <dbReference type="KEGG" id="aten:116298354"/>
    <dbReference type="InParanoid" id="A0A6P8ICE2"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11721">
        <property type="entry name" value="FANCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1281"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1328"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562635.1"/>
        </source>
    </evidence>
    <sequence length="1340" mass="149785" checksum="0F533D8668916610" modified="2020-12-02" version="1">MARSKRKSKKKAEEVVVSAKKGRQTESITSDIDNTGFDQLVANAGIFLKNSDDSQDEIGVDVPIFQKRLTAAIKSHQNYPKVIEEFVESLQKRSETPERFRLSLLPILVAEESEGSIHGHNQESLIRILLGIDLLQPRIANMLLEKLPELMGDENGHGSNNGETNTARLIMNQFRWLDRIVNSKELTEKMLEMVSITSPDVQHEIITCLPEVVDDTEHTGVALQLRELLLQNTSLAVPILYALSNLNLRQDLLAEVRVSVLQMLPSAELDDLPVVTKFILQSVSDNDAFEVISELRMNLDFGSLIPQSSSTPLNPRQEGASASADKDGELLTLDAIRSGIRFQKSVAEGWLKAIESVNSAALHKVIDLFVLLILHSTGNRKKTVESLFRNKIKVGHFTEEMLSSAFNSHNQILREYFSNLLSLGEVLLRSPETSVSSYACAIYRLAFASFDLYCKQEIVGALVTHIGSGFATEADSSLDVLSDLVETHPKIMAPFAVFIKGILDYLDNLTLSQIRKVFSMLSTLAFSSPRDGAMIQDDVHIVIRKQLSSSCPKYKRIGIIGAVMIVRSMARKRSDDDNAATSSQFFSSISNDIYKQIVNLLDMVRSSVARVPEAAALFYDELTRVIEQGDVDRKIKNWISETVVSDFQEDFLVDRDAPLPKDTLPIEFVYGLDEAEEGSIALNILPLLLTAAAATSKPQSVLDKPPVASLVCLAPHFRLLRICEQSQHNGDLEGIDALLGCPLITFKFDMLEEINTLAQADREVMCKALFYTVNWFIELINGFATQGDPEMKGKTLTRLNDITCLYKQIETSLTATPTFTPSLATFDGESPAPVVLQTATKGKRSRKASKGNETKKLDETIEKLADKENDKDLDSSSVSVVEKDKRKDKASSFSMSQCRPYLRWMLLANNDGIMDGPGCNTEEASIMNQCYHLLFSCLQTFFSWSGFLSSENQGLLKKALTVLSSRTKLSNLTQSGLQELLKQSFHYLEQFSNTMIDMATALTLTKLLVVLSERLDNQEINKAIAKLTGGFLKREWIKSNGEKDSGPKYNEALQYLLRFNFSFSEDPLAAIEEITAGAFTELMEDDTCAASESYPTLTRSTVPSFYRAVFEELIAYLKQTHGVPLKRTDVEQANERLTQLNIIVREFHILINLVKAFDQRQVLASALKLGRIFVETFLKLGMPLLDQTLRTNKDVVHGLLKNLQQSTRCLQHFCGHTKVFKDIALTNHVPAVKKCLELFVFRVKVMLTVNQCHEAFWMGNLKNRDIQGQEILSQQSTRGDEDNDNDDDDDKQNEDQEMEVVNDNDEDDDDDEDEKNEAESVVSHDSGGGDDDEDSCSDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICH3</accession>
    <name>A0A6P8ICH3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinase kinase kinase</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116298968</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031563422.1">
        <property type="nucleotide sequence ID" value="XM_031707562.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ICH3">
        <property type="interactions" value="2683"/>
    </dbReference>
    <dbReference type="GeneID" id="116298968"/>
    <dbReference type="KEGG" id="aten:116298968"/>
    <dbReference type="InParanoid" id="A0A6P8ICH3"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06613">
        <property type="entry name" value="STKc_MAP4K3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000031">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038172">
        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="15">
        <location>
            <begin position="480"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="375"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031563422.1"/>
        </source>
    </evidence>
    <sequence length="806" mass="90065" checksum="2F8A325FBADA5585" modified="2020-12-02" version="1">MSVPLKANISRGNPDKVFDLIEKIGGGTYGDVFKARVIATGELAAVKVVKVEPGDDFELIQQEIAMMQQCHHSNIINYIGSYMRREKLWIGMEFCGGGSLQDIYCVAGPCSEPQIAFVTTETLKGLAYLHEKNLMHRDIKGANILLATNGDVKLADFGISARITDTMKKRKSFIGTPYWMAPEMAAVERTGGYDLKCDIWAVGITVIELAELQPPMFDLHPMRALYVIGKKNFIPPTLKEKDKWSAEMHHFIKVALVKNPKKRPGADKMLTHPFCCRHLTKAVTQDLIDKFKTQQDERSFPLDGSDDEEETIDEHVKVMTRIRSTKPHEKSSKNMSGGILDGVEVDPIAKRATKQHFQGVDSSIEDDDTMQATGTFKAKQPEEEDDEPPPLPPKETKDHYKVPRLQSLKPAPPPKPDHLKLTKSTSNGGGAPRHPPPTAPPPKPPISKPSYVSINGVPPPLPRPKNVVTTCFSKIFNECPLHIHCTATWVNXKTKSKYILIGANEGIYSLNISEQAPDIEMEQISSKKCTWLAVIEDMMVSITGVPPCVSMHNLLSLHDKQQQTFFNTVTRGVVYSQRIAETRGCTKCCIVNNPYNGQLYLCVALPNGILLMQWYEPLGKFMKVNMYEVRLPSPLTLFETLVMPDMDYPFIVVGIQEKSERALNFDLVNLNSTSNWYTEHKDGKKLSVDHFDQLEKETILICADNIIRFVNLEGRPKQTKRGVSEIRFDVKPESVVCLQGSVLGFHEHGLQGRSLLTGQVSVEMNDQKRTFRLLGADSIAVVESKPTHDPQGPCNLYILASAPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICM8</accession>
    <name>A0A6P8ICM8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116299028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031563512.1">
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
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            <end position="230"/>
        </location>
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            <end position="459"/>
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            <end position="726"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDB7</accession>
    <name>A0A6P8IDB7_ACTTE</name>
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        <submittedName>
            <fullName evidence="5">Chromatin target of PRMT1 protein-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">LOC116298924</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563365.1">
        <property type="nucleotide sequence ID" value="XM_031707505.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="CTOP_PRMT1"/>
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        <property type="entry name" value="CHROMATIN TARGET OF PRMT1 PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="160"/>
            <end position="244"/>
        </location>
    </feature>
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            <begin position="70"/>
            <end position="219"/>
        </location>
    </feature>
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            <begin position="108"/>
            <end position="121"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="2">
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            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
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            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563365.1"/>
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    <sequence length="246" mass="25477" checksum="CA44DABC72A6AAA9" modified="2020-12-02" version="1">MSAIPAKIVLKSTTSKTLNDRFTEIARQIKSPPQVTLGGLRMGQMQQSQASSKNRRLAAQMANRPGVQAALGLSPPGGRVQNRLGNQNKGSVQGRLGSNKMTGFRPAGRGGQGGFRGGQGGVQQRIGSGRGGLRKGTGLKRGFGAGAGRGRLNRGGGMSRGVGRGMRGGMGGGRGKAQXSRGAGAARGRGAGRGGRGRGRGRGGQTNPVKSRDALDKELDEYMTQTKGHLDAELDQYMQNVATDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDN9</accession>
    <name>A0A6P8IDN9_ACTTE</name>
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        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein on Y chromosome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116299880</name>
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    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031708597.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF6">
        <property type="entry name" value="EF-HAND CALCIUM BINDING DOMAIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="513"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="591"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="872"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1104"/>
        </location>
    </feature>
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        <location>
            <position position="747"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00014901"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031564457.1"/>
        </source>
    </evidence>
    <sequence length="1104" mass="124502" checksum="1CEF4A265F608EC0" modified="2020-12-02" version="1">MIRLEDQMNNESLEMLQQIFQEADEDGGGGLDLDEFRQAMIKTMAGRGEIPDDNQLSIIFMKVDANCDGTVDWEEFCSYMLMENQLKDVMTSVDREMEFPYPAREIPSSHRDTIQRITYYPKMTHGGDDPADNIGGRYLTVSKDGILHFWSMDLHNLRTHTLLEGKSSSTQRTMWVTDCVVLPNAKKVAVSSADREIVFYDCSANSFEKQFVLCGLEYCVVTMDYWFNPHKLNESVLLFGDAGGSVRCIKFSAAVNNLFDLTLGQAIPSVNCRRVSLAEIFLGRHANVQAMQFNELHEDWVRKVRYYPTLQCFISCASSSNNSMYLGDLDRKKTRSMFRTRKGINSFDYCKEWNVIVTGGLDHHLRLWNPYVPTKPTSILKGHSACITHILINSEQXEIISAAQDKVIKIWDMRDLCCVQTILSRTLLPGPHPISSLYYSNKLHCILVGTNQLSLLEGKNEDPSEEHEVASHTKPLCGALYNDLFDQVVSCCHDSVVCVWSLENGEKIIQFANAHGDSEITAMTFDQSKRRLITGARDGSVKLWNFNNGCCLRITGIVSFKQSIVVVGWSKKMIVYKDYREEEEDVPRIWPAHHKDDILSISFYSPNLVATSCYNGDLKVWNLDTGHTLCVLNANNFNIPIMSKPVIPLELKRRVSENNAVLSAVLADLMQHRRVSTIDPKHLSGFKSPLGKSSILKDPSLHALSKRARSICPVMNKVDVKDSDYDSVVDKVMFLQKREHHRDTATLVTGESGGLVRAWSIFGGGLLGQFVAGHTERESITTLTTDENNTMLITGDTIGYVKVWDITEYCINKPENAKTAIKNRLKESRGSFLPTLVEKDSTNFVQQEGVANKPPQPDREINLVPPPLLFKFRAHLSCVSCLDYIQKRKLLVTSSVDASVRLWTYQGKYIGTFGQRSLWNLGRAIKAAKKIPNDIQRVASPDTMASLGTSGSQKWRVAKHILRITRLGMQLANKAKKVDTEAETVSINIEESLKNVLGKHYQPRKRHRSLPSFQKPQFNQNQVVVYSSLPYKDMDVLEEPRLPSTLAHHGHKASSAHLGDTNKNVRKSHAPTSGTPFKQGFRRPASRESARRHVKVNKSPECLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFA3</accession>
    <name>A0A6P8IFA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Trimeric intracellular cation channel type 1B.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116300643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM38 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565406.1">
        <property type="nucleotide sequence ID" value="XM_031709546.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFA3">
        <property type="interactions" value="1132"/>
    </dbReference>
    <dbReference type="GeneID" id="116300643"/>
    <dbReference type="KEGG" id="aten:116300643"/>
    <dbReference type="InParanoid" id="A0A6P8IFA3"/>
    <dbReference type="OrthoDB" id="195817at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007866">
        <property type="entry name" value="TRIC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454:SF11">
        <property type="entry name" value="GH25683P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12454">
        <property type="entry name" value="TRIMERIC INTRACELLULAR CATION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05197">
        <property type="entry name" value="TRIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031565406.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27105" checksum="CAEDC7FC42A498E6" modified="2020-12-02" version="1">MEQFYTIFDDFAHRFYNLPMFPLLQCGHFVIVTLGLRRNIGLTFARSNPLACLVSTLIANLSGVLLINLLLGRPIILFFQDERQIMIITGIWFQTIIILLKEAHRAKGILGGVELGXSLYPDAVLITVIFGFLKGAAGLLTEPLGAAIRGTLTIEKNQAVKPSYNSKVSFCVSIIYTMCRKGIITVSLPYLCLTAYIVLAIVQVTLYWTGGGDPFTSIENALSPYCFGSPSVESNSSQTKEKSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG61</accession>
    <name>A0A6P8IG61_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031565732.1">
        <property type="nucleotide sequence ID" value="XM_031709872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300903"/>
    <dbReference type="KEGG" id="aten:116300903"/>
    <dbReference type="InParanoid" id="A0A6P8IG61"/>
    <dbReference type="OrthoDB" id="6042561at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028109911" evidence="1">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565732.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30842" checksum="9FDB53FFB95389E5" modified="2020-12-02" version="1">MKIFLLLVLVLLTGSSQAWFWNKKKPKVEQPDWDNLRVTFLKFNKLPLSEFDAKKKGWTLTATCDAKNYFAGHRYVLNGDRAVMLLYDSNGKIAGIQMGIPKSEVAPKNHPWISEGDFYVITAYFVDPATICNGKRPDSKYIGDRLLIQTGSSVNSVMRIPYKQGDLVGTGWVEGKCFYLMGKHYWYKISRKMKCEDFFPVFLLYNRGKLNGFGWNTIGDXKSSRYEHPPARVLKRFFYPGTHPQCLKDAGPITTQHIYFDSPYNNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGL2</accession>
    <name>A0A6P8IGL2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Melanocyte-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565937.1">
        <property type="nucleotide sequence ID" value="XM_031710077.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IGL2">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="GeneID" id="116301078"/>
    <dbReference type="KEGG" id="aten:116301078"/>
    <dbReference type="InParanoid" id="A0A6P8IGL2"/>
    <dbReference type="OrthoDB" id="5983689at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031565937.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35576" checksum="EF3778E96E09D9FC" modified="2020-12-02" version="1">MNGEYYFNTLTLKLPTFRTTISVLYSLTSFTATLLNILVLISIWKTESLYKPSFLLIAXLALVDLLAGSVAEPLILVTNIAAIQGWSNVFCVCSLAARVVAYWLGSVSLYTLTVISVDRLLAIRLKNRYRSVVTMKRVKAVLLPWWIMVFIAVLSVFVFHASIRTLVIAIATGVFVLLIVLSVSYSMSFYYLKKLSNSVASTDKTEDRTDSNFNRSKYQKSLKTMLLLFCNVISLFLPFFCAATTVVVKGVEKFDENPTSMLVYKLLMTSEFIVAVSSTINPLMYIWRIKDLRKAMKTTLRKILGLKVDENIEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHH5</accession>
    <name>A0A6P8IHH5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chloride channel CLIC-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116301276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel MCLC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566169.1">
        <property type="nucleotide sequence ID" value="XM_031710309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHH5"/>
    <dbReference type="FunCoup" id="A0A6P8IHH5">
        <property type="interactions" value="1569"/>
    </dbReference>
    <dbReference type="GeneID" id="116301276"/>
    <dbReference type="KEGG" id="aten:116301276"/>
    <dbReference type="InParanoid" id="A0A6P8IHH5"/>
    <dbReference type="OrthoDB" id="10037397at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009231">
        <property type="entry name" value="Chloride_chnl_CLIC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093:SF1">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05934">
        <property type="entry name" value="MCLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027580405" description="Chloride channel CLIC-like protein 1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031566169.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="56660" checksum="1B78C5CA537DB0B1" modified="2020-12-02" version="1">MKLFKVLLVFLMSFVVIVCASDEKEDEEILSGIKDDWIDPHNMVDDTRVGSQGRWDKNGVGNHEWLDFMGACREKDSETALRSAFSNIQDELRSCKKKLEASSSSSSKQAEDIPIETASCDTPYFKQLVRVIHEATSNLKPFTEINLSAEQREIFKKFLNDEANIHDVNTILLNSITNRTMSDSFIDKSKVFFQSVLNTEALIFVIFLTVLVMLFIIFQIKTRLTALQQLSFLLIMLFIISIPWEWCRLYKKEFAKKQGIMMETLQKHCKTDHELGPIESLNLLWKSSFSTDDSSCAKYQEALLVDAVWEVAPSMAVSVTITRFFVQPLEHIADAVGKSFRALFQHLPLQWQPLMFLACLVITILLLICVRGFHVSSPFLRFGVGGQPALNNEHLLRIEHQMQQMAENKNVPAIENVRNGDQAIIQAILDITRAMNERSQQHDTLLREIRNKVQDIRRHCRQEEAVEHPDWELVENNRAPIPVSDQHATENGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKP9</accession>
    <name>A0A6P8IKP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cotranscriptional regulator FAM172A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567332.1">
        <property type="nucleotide sequence ID" value="XM_031711472.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IKP9">
        <property type="interactions" value="3013"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116302238"/>
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    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028920">
        <property type="entry name" value="Tox-ART-HYD1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15633">
        <property type="entry name" value="Tox-ART-HYD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tox-ART-HYD1" evidence="2">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="5">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567332.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34421" checksum="5F9A7FD25308B48B" modified="2020-12-02" version="1">MNQNRYEDLGEAITEYVYEYLENKLDLEKVTIPVDARPNEPKGFFFMSKDALECSKLMILIHGSGVERAGQWARSLIINDSFESGTMVPYIEEAMKEGFGVLITNGNHNYDEKLHKCVKGSENPQDHFVYVWNNFIKKAKAEHIVIVAHSYGGQVVLHGLRNIKEAKERIKAVAFTDSVHSVGXXESRDIKQFFKKRTRNWVSSSDKLDTPIRSYYEGDTCELVSAGTTEHVWISHYAKDSVFSFFKKKLDKEKKEKENVLYHYTSEKGAEAISQDKKIKASTRGNDDAVYGQGSNYMNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL03</accession>
    <name>A0A6P8IL03_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intraflagellar transport protein 88 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567447.1">
        <property type="nucleotide sequence ID" value="XM_031711587.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IL03">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="GeneID" id="116302307"/>
    <dbReference type="KEGG" id="aten:116302307"/>
    <dbReference type="InParanoid" id="A0A6P8IL03"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000283">
        <property type="entry name" value="Intraflagellar transport 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000106">
        <property type="entry name" value="Intraflagellar transport 88 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="720"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567447.1"/>
        </source>
    </evidence>
    <sequence length="837" mass="94180" checksum="3B945C77A341BEFF" modified="2020-12-02" version="1">MLQSVHLVGEEEDDIYGGFNDYEPAFATENLEEDEAFQQALKTSHGQRPGVKTGKMTAVGARGKVPGSSMGRPTTGIAADTSQARPMTAVRSVGYSSSGNRGVGGQFDPLNQTRGPAPPLEAKAEDSPEEKVKQLEKKVNELIEESCIANDRGDFALALEKAKEAGRKERSLCRQREQTSLSEQMNLDLTYSVLFNLANQYHTNKMFNESLNTYQVIVKNKMFSNAGRLRVNMGNIYFEQKKYPQAIKHYRMALDQVPNTHREMRIKIMQNIGVAFVKMGQYSDAVTSFEHIMVEKANFQTGFNLILCYFGLGDREKMKKTFQKLLSIDLGIDDEDKYTATQDDNLQMMILEVIRNDKLREIERKKKSQAEKFIMGAAKLISPAIENNFAAGFDWCIDCVKVSPYMELANELEITKAVTYLKQKDLNKAVECLKGFEKKDSKVQSTAATDLSFLYFLENDFNQADKYAELAMSTDRYNPAALVNKGNCLYAQGEYEKARDFYQEAYNVEATCTEALYNLGLVFKKLGQYEDALDCFTKLHAILRNHPQVIYQLANIYELLEDMNQATEWYMQLVSVVPTDPFVLAKLGEIYDNEQDKSQAFQYHYESYRYFPSNIEIISWLGAYYIDSQFCEKAIHYFERAAVIQPNEVKWQLMIASCYRRSGNYQQALETYKAIHQKFPENVECLKFLVRICTDLGLKDVQEYAQKLKKAEKARELKQQRASSGSSRKGSGRXGSASRPGAAGSRNSSAGSDSSRIGSGTGTRGIGSAGSKAGHARPTLADTDDLYNVASPKEVDATYSDPLGEAPARPKTAGRQRHQPQEDEFGDEELGDDLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPP2</accession>
    <name>A0A6P8IPP2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Taste receptor type 2 member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569026.1">
        <property type="nucleotide sequence ID" value="XM_031713166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPP2"/>
    <dbReference type="GeneID" id="116303594"/>
    <dbReference type="KEGG" id="aten:116303594"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569026.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39081" checksum="F2F74FA051F1840B" modified="2020-12-02" version="1">MLYKNTTNFSFNAFLNESRCNSSSGSCSPVQTCPGTVVHLAYISVIWVIGVLGNILLLYVDYKEWKKSKTPDKLLILNLAITNVAALLVSLPLHAVLVANYQDYLKCAGSLFQYRSARFFLICLFNFVSLGTLLVIGIDRYQALIKFAHQRTLDLKRSIFAICLVWLCSITVVVVFIVTWPNQCTDFYSSRLEDRNTDNYYPMRITIISIWITVCCTVTGRSLLMAASRIRKQQQKIKTMFGPVQAAAQISFTKGVIGLLLCYVVLWIPYGVSSAILSSDQQNIELTWLNLWTNSTCYLSFSILPAIYFIVDNRLRRAILPEKVVAPKVTKTQSLTLPNPTEIESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQX5</accession>
    <name>A0A6P8IQX5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA ligase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116303419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568810.1">
        <property type="nucleotide sequence ID" value="XM_031712950.1"/>
    </dbReference>
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        <property type="interactions" value="2144"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
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    </dbReference>
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        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
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        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase ATP-dependent N-terminal" evidence="9">
        <location>
            <begin position="361"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
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            <end position="235"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
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            <dbReference type="Pfam" id="PF04675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031568810.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="64366" checksum="5858F60A6D6F8181" modified="2020-12-02" version="1">MSQKSISAFFRPSTKVQEKNDETKTKAGDEAPEKPKQQTPIKDSKPTALLDSPPVKKSRRKVARVLEDSSDEENDAMDTTTAKQEAKTNGVDRNESESKMNGERENGTQKTINGDKNTDESKATDSPTDDDFIPKRTTARKHMRKRKASSENNTTNKEKPVTATQNDMSDEKSSEEELKTDVSSPVAKKTKTEKDADNKISPKSFKKEKQEMKEKSEEKLKGNKTKSTKDKKSSSDSENGTMEVCSAESDTTMDKKNSSKEEKSTSDSEKDGKKDESKKSAFSKFFFSPRQPSKSSKLKEAKREEATIKTEKKSPKEEKHNTHKNDAGEDHEPVDASEYNPEKNCYNPIKHACWKRGERVPYLAVARTFQAIEETSARLKIMSILSNLLRSVIVLSPNDLLPCVYLCLNKLAPAYEGIELGIGDHILMKAVAESTGRNLQLIKADLAEKGDLGLVAEASRSNQRTMFAPPKLTAVGVFSKLKEISLLTGHSSMSRKVDIIKGMFVACRHSEARYLIRSLGGKLRIGLAEQSVLTALAHAAVLTPPCQEYPPPVLDASKTVSSEELKKKFEEAALIVKSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQZ2</accession>
    <name>A0A6P8IQZ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116303436 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568825.1">
        <property type="nucleotide sequence ID" value="XM_031712965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQZ2"/>
    <dbReference type="GeneID" id="116303436"/>
    <dbReference type="KEGG" id="aten:116303436"/>
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    <dbReference type="OrthoDB" id="300289at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STB6_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="334"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568825.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="99938" checksum="E7443CCB62744B8A" modified="2020-12-02" version="1">MPLSVPVKPPSRSFLEAAESSKLLDWELDSIKTEREENVARSLFHYRNLKSELKNQCEISRNLQEDMDESSSYEAATVWVMGSWEALESLEGKREESKEYMKRIAQLSREILTLKIQILCAKVVHVGAVIKQLQELEASAGPKSTTPPELLFHKFEEWVQSNEQIYNLQSSILNLEAQKVRLHKSIRTEHARQLSVSSIATKGSFASALEDHPGKNTESGLMLQFADEPMVSHIPSKQEAMLDKLLVVSSQNKSFESFKLKAYIRECWEVKHVDDDFPTGVHQDRYQEFIGGMCQYIVDKPTYSFLSYDAVFAKLEHHLMPEIYSRVQEHVSRPEDDAKLARFGKNLAFLSQSQFGIKPECQDISLSPYYAAISALKASSMCLIPTRKIFQIVRAAKLVFENLNEIAAQDNRSPPGADEFMDVWVYVVLKANIPKLASTVAYLKKYCNPNLAFTEAGYYLSSVEFACQYILRLNEHEFPVHQGKKIDKIVVCEQRRYRQLASEGASVFEAVSENEWLKGYQMFAVKEWQLDPLRYFSTVLVPTDDQSAKVKVSVVRVNKEVVSASQLEYLKSCFLEPSAAHGLASVNTHLGSTVILYSSNAQRSLTLIPIKSGQYDEVEDSLKWYCTLERLSCIQPRNQTVRMNPENTSTDTELDKSGDTKRKVQTQCLSSDLTLLHLHSEHSEHEGLFDNSIGITDSLEKKEPMDIISTDFVLDAAQHKNVLVQSVYYNDEEKKTASNLMTVLLNYLYILGYLSHLIDIPEPYFNNVIVLAVRHFQLDYNSYSPDDTLPTSGHLTPATLKALTELLKTTIEKLNRLGFHFEGELHLSREKEWIAFSKFVSHCQDSMVINIHMKGALDRQTREEIDRLVADLRCHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRK4</accession>
    <name>A0A6P8IRK4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RING finger protein 121-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569000.1">
        <property type="nucleotide sequence ID" value="XM_031713140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRK4"/>
    <dbReference type="FunCoup" id="A0A6P8IRK4">
        <property type="interactions" value="1251"/>
    </dbReference>
    <dbReference type="GeneID" id="116303575"/>
    <dbReference type="KEGG" id="aten:116303575"/>
    <dbReference type="InParanoid" id="A0A6P8IRK4"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16475">
        <property type="entry name" value="RING-H2_RNF121-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000074">
        <property type="entry name" value="Ring finger protein 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF0">
        <property type="entry name" value="FI05221P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569000.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37776" checksum="E505CA4A4B3EFEF0" modified="2020-12-02" version="1">MADEQGNVVIISNDTIAITRKLSKEELWRIEHEKLHAKHKGHEAMHMEMVLILFATLIVAQIVLVKWKKLHYKSYQTVSLIGMWLIPVYFNIKLFYWRMMIVWVLFSLATGFIVYKATRTPISNTTPRLVYKWFYTVHKVTYFLGVAGYFVIMLTLLGVNLMFLIRPEVSMEYGIVIMFYGLYYGVLGRDFAEICSEKIASKIGYYSKSGLPNRSLETNICAVCGQQLIISDVDEDEMPEKTYKLTCGHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFCNPWERPHVLFGQLLDWLRYLVVWQPVIIVIVQCIIYMLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISC9</accession>
    <name>A0A6P8ISC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine/tyrosine-interacting protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569240.1">
        <property type="nucleotide sequence ID" value="XM_031713380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISC9"/>
    <dbReference type="FunCoup" id="A0A6P8ISC9">
        <property type="interactions" value="2149"/>
    </dbReference>
    <dbReference type="GeneID" id="116303779"/>
    <dbReference type="KEGG" id="aten:116303779"/>
    <dbReference type="InParanoid" id="A0A6P8ISC9"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14522">
        <property type="entry name" value="DSP_STYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000036">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569240.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24714" checksum="64F3085C40A5CCF3" modified="2020-12-02" version="1">MQSSGGPGRLFDFPEIPNKDDVVDWTYSKRRDMQEIVPRIYLGPYSAAMKSKFDNLKAHSITHIVCIRQDIEANFVKPNFKNDFKYLILDVADLPTENIIKHFPQVKAFIDEGLSSAGNVLLHGNAGISRSAALMIAYIMETYGLSYRDAFQHVQQKRFCINPNEGFAHQLMEYEPIYLANYQARQQQIDCQAIDRRNAGIKRPFEDEIDGDDGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISG2</accession>
    <name>A0A6P8ISG2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304334</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569914.1">
        <property type="nucleotide sequence ID" value="XM_031714054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISG2"/>
    <dbReference type="GeneID" id="116304334"/>
    <dbReference type="KEGG" id="aten:116304334"/>
    <dbReference type="InParanoid" id="A0A6P8ISG2"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569914.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33524" checksum="481EE7AD92B5FC15" modified="2020-12-02" version="1">VQEKAYKGLMCMQKQLGNSQQLEFTLFLLHGTNQEIETQISAINQFVKSKIPPGILVNFLEPSSDDDNYTFPVPLCGQGYVKCDVNVNGNTCCVRFYHDEVFVSIPDIKEKSGRCIDGAPAHETRLHDPDLPACIRFSLFCKTPMEMRTPTNFKVVLTTTDENRTEIFGNHKAEKYFSACFYGTDEMSQKNPNAGNSLMPLNDWKILVDNHDNICDIQDWDAIIKWFVTDGALDKKFLNESLSKERKGEIMRHLYQVENIFHKFIDALQTTGGNGELINLLLQCMASMENQNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITN5</accession>
    <name>A0A6P8ITN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304942</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031570606.1">
        <property type="nucleotide sequence ID" value="XM_031714746.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304942"/>
    <dbReference type="KEGG" id="aten:116304942"/>
    <dbReference type="InParanoid" id="A0A6P8ITN5"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570606.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="60269" checksum="D2C1042377E77E6E" modified="2020-12-02" version="1">MFQKGTKITIIDRYGTNKYLCQNDKAELGYVNEENISFKIAPVELTLNKPKISSPFGMRHTNCVAILKKHKETGVFPVEVENLVALAAKDSQANISVEPKPCSSQVQKDEGSEGAGQALYTLMDGGRQHVDHETKSVKLGVSRQNLIPPPIPKRADILEQIQSSHSKTLPAKKIKPVPKPRKIRPKSTNVEKQDSQLEWVSTIDSHRDDIKESKQCASVKSEGEESSFPQCKEEIREENSFMYKEKEPELVINETEQSAQIEPNNEETNVDDLADLNNLISFDKEPMSSSVPIRDSHPQGACKETFPSLPSLPVTAANDTTDSAREMPSNHSEVREGLLIDLALHENVEKQKEDATHDNVPPPLPPKDIISRKVEDLVPRPVLRPVPRPIPVSQTPTSMQSSCASASNHTIDPSTLTYPSSYLNERTSGSDRPVYSRPFPTTLPKLPPRQIETTSSVEKKXAYGDEINEGIAKIQLEFPDISKDTCYARILEYKGDIDHIVKVLQVCSLANVTEXEANFHLGHCAWNVQRTVNYIFDNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITU6</accession>
    <name>A0A6P8ITU6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304807</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570454.1">
        <property type="nucleotide sequence ID" value="XM_031714594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304807"/>
    <dbReference type="KEGG" id="aten:116304807"/>
    <dbReference type="InParanoid" id="A0A6P8ITU6"/>
    <dbReference type="OrthoDB" id="10346373at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570454.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26489" checksum="18CFD96DDB2AC64B" modified="2020-12-02" version="1">MQKKLEKIPSDVIELMDLAIYSFACISGLKSSDKVRGNPVVLGVLAMFFKMLEVAKESTRGAFQARFVDATVDKPGRFEKAVCSRLKLAKAKKLNETGPPDIPSSLQEKVERFNEATERVRTKYYXRCWRCQERCRCCVLRRKGKPVAAFGSELMSPFLSSLDAIADAKAFLDPDEEEEPSMPDGLEEIADDEADKLMDRFFKEDISDDENEDDDDDDEEEDSKDDMSEVDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW52</accession>
    <name>A0A6P8IW52_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Restin homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570328.1">
        <property type="nucleotide sequence ID" value="XM_031714468.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304694"/>
    <dbReference type="KEGG" id="aten:116304694"/>
    <dbReference type="InParanoid" id="A0A6P8IW52"/>
    <dbReference type="OrthoDB" id="5984635at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570328.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41476" checksum="644995CF3B5A8061" modified="2020-12-02" version="1">MENGLQKYILLNDRFGEHVEKVCCSKKTIPIQLFRGDILECLPESEQPKDPKKIALSSMDLNINIELECPLLGVSKLTDSEADLLLSVSSLEERFRVYLNERNLLQQSNLDVGHKVFVRIGTTRELDGIIWYKGRLHGHNGTWFGVELLGKESEGQGTCDGTFRNKTFFACPADRGVFVAVDALRPRQEQDKPPQKETTIFSTLKYMIPSFSSKDTSAVRNMAIGHKLKIDQRVVVFPEXDDDKVPLRGTVRYISKRVDSHGDCPVGIELDRKKGKGTGEFKERQRFVCREGYAFFVPVTSVIPEEDFDGARTENSQESSSSEADGLGSSIENTVHFHQMFRASCSLIKSGRCDPYVTENVDTREIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW77</accession>
    <name>A0A6P8IW77_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malignant T-cell-amplified sequence 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116305776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571611.1">
        <property type="nucleotide sequence ID" value="XM_031715751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW77"/>
    <dbReference type="FunCoup" id="A0A6P8IW77">
        <property type="interactions" value="1330"/>
    </dbReference>
    <dbReference type="GeneID" id="116305776"/>
    <dbReference type="KEGG" id="aten:116305776"/>
    <dbReference type="InParanoid" id="A0A6P8IW77"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000001">
        <property type="entry name" value="Malignant T-cell-amplified sequence 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="5">
        <location>
            <begin position="93"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031571611.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20594" checksum="3AAB3665B01693FF" modified="2020-12-02" version="1">MFKKFQHKENVSGVTQVKSSVQRGIKNKIVEQFPPIADYINQIFPKKDPMVVVKCHDHIEILSVNQELLFFRQRDGTYYPSLRLLHQYPCMLPHEQVDRGAIRFILSGANIMCPGLTSPGAKMVQQPKDAVVAIMAEGKQHALAIGVLKMSTDEISSVNKGIGVENIHYLNDGLWQMKHLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWI5</accession>
    <name>A0A6P8IWI5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protrudin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger FYVE domain-containing protein 27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116304771</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Growth cone membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570413.1">
        <property type="nucleotide sequence ID" value="XM_031714553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWI5"/>
    <dbReference type="FunCoup" id="A0A6P8IWI5">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="GeneID" id="116304771"/>
    <dbReference type="KEGG" id="aten:116304771"/>
    <dbReference type="InParanoid" id="A0A6P8IWI5"/>
    <dbReference type="OrthoDB" id="5975347at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071787">
        <property type="term" value="P:endoplasmic reticulum tubular network formation"/>
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        <property type="term" value="P:protein localization to plasma membrane"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd15723">
        <property type="entry name" value="FYVE_protrudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042405">
        <property type="entry name" value="Protrudin"/>
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    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
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    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14543">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR14543:SF1">
        <property type="entry name" value="PROTRUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="88"/>
            <end position="107"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="181"/>
            <end position="201"/>
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    </feature>
    <feature type="domain" description="FYVE-type" evidence="19">
        <location>
            <begin position="323"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004460"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015523"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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        <source>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50178"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031570413.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45559" checksum="22551C4578D16490" modified="2020-12-02" version="1">MCEAKDDTTDNTEQSHGLLREDQANQNNNGVGKFDIGDFVHNQRKIRLLIMPWIRFYHTIFNIVSWKSFYVSLFWMSTNCFIAVMSPIYFVILPLAYVSLLMIISGVKQWGAQGQKEKKLKYGTIKKKADDNDLNVKVTVEKQAHEDIKEFISLLIQLDAFNTEICTFFEKCQRILKWEDLQTSVCVLFGLLLAILVLCFIPIRLLILSGILCVFCLNFGFRPVARSISLIFGKYLKKLVTLLGINELFPSRDIRRIPSQSANSDLQDEWFDAAEDKSDTGISSDDDGSDTNDAQGEQSSSQRKLDSKSVLSQIADFRRKQKKLNSGTCSSCDVPFSILKKRQYCRHCGKSFCSRCCSHRVKRSVFGATAPAAYEETVLVCNTCYDLLMKGTPEEQPSGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWI7</accession>
    <name>A0A6P8IWI7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC116305894 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116305894</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571751.1">
        <property type="nucleotide sequence ID" value="XM_031715891.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305894"/>
    <dbReference type="KEGG" id="aten:116305894"/>
    <dbReference type="InParanoid" id="A0A6P8IWI7"/>
    <dbReference type="OrthoDB" id="5322100at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028244412" evidence="12">
        <location>
            <begin position="21"/>
            <end position="2670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1639"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1851"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1890"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1974"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2009"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2112"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2377"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2415"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2464"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2504"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2567"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="13">
        <location>
            <begin position="1685"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1529"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1922"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2046"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2631"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1309"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1324"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1384"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1529"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1540"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1927"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2054"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="2631"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2645"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="2211"/>
            <end position="2227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031571751.1"/>
        </source>
    </evidence>
    <sequence length="2670" mass="297945" checksum="B424E7867AEBA7FF" modified="2020-12-02" version="1">MHQFSIFLLLIAGQAGLCLSSSANWNCSEYYNNRTVTTSRLSYCYTLISGATTISLEGQDPLLMNPLSSRTTSEKVLFCAKAAQGRGFRSFSLKDGGNCKVGGTYSYFSCSYNTFSGSCSNPTYPCIRYLTTSCQCGTSSGLGKSNYYNRYHVSTSYGSYLGMWLEVEDVFNNTVEMFNATSPKYIDLYKTYKSAIKAYVNDSKICGVNLNNIGPAFIRPKNGPGPILLHFQLMVSFFNLTIVREKLEHFPYHTLNVTEFSIRXISGNCKEDHRRLYLNLNGGTSITSPIVQKRSGFPLRYSVSSSCVTPLRTNVTIKIASISKDGYISNFTTFCSTELLNLISLSHFCQIPPLSLNEGLHYVIGEARTPQDPSMHGFDYVFMNITKGELFAHITEATGCVHVLGILSYLNASGSYDKNAFATDLEAIRYPNDLRYTWVCYKTGDSMTATTPTKARSLPFVESGVPILGRSGGCFGYGPGRLRVTTRATYFESSHLTVGEYVYFRVFIEKGERFAYVTKSCLITPAPEKFGVRCKFNCGPLMKTTARIGLEPVCEDPAGCSIKLVHSWKFFVDTEREIDNGDGTSERVWQPYYAMKTLTETTNIYIVVDKLSFEQNKTYRAQHIVKNDKGGIRVTNYNFTTNTFPHSGTCEADKTTLQAGIDTVNITCRDWVDEQPYLSYEAWIVPHNTEPRLVYFGNSTSFKLRLPLGDSANNFTLQMEIKIFDIYESTSFFMNFTVIEPIVDDPVGAMFNLVGQEGDDEDANEQETAQKSIATLSLLGNNFASNISVENKTLIRNSIISKMSNFSANDTQSISQVTGVLIDSTSKTDELSSEGQMQSIQAAFGMSESLKNDNSTDDPAIFEQVGTTLLHLTGNVLDGAATNNTSTKESGAAKALGETALNTSNTISSMLIGKMMGGEKAKTFLTPSLGLEISKTESDKLPETYTVNGGGVDVPPVMKSLIGKATECTSNEICLAADTFVSTKMLFSNSNPYTWGNGSLEVKSPVVSLDYLTNGGDTIPVGGLDTDFKLSIPTKPTPKPNKTSEFPDFVTPNTDCAMHKFYIANNDTAFETIINPVEETFVTVFVRHNMRPTEEKYDYVFHHPNLSSCVEPPERDNCTGVFDFTECMGLNRTSEKLSDERCGDVTIPNIGPFSNNTNLTLGQETCIDYHNAVTCPVVECNLNSSGNSSGQNISQIAAINGNHSSLCGNLTNGNHTSDNSTSNNKTDVCQKVKDFLYCKNASMEKYEKCKXLLTKKKLIYGKYDNCSENIYRTFFGLDIFRQGGWYYASICYPARQKHVPTTPKPTTPKPTTQVPTTRVPTTEADGDGDGDGDGGGDGDGGGGGGWSSVTPKPTTPKPTTQVPTTRVPTTEADGDGDGGGGGGSRRRGKGERDRKKRSFNRDQTKWMKDDILDSYEGNVVDVTEDTTEHDVFKIDRDIDFTLKHSLDGHSYDSIKAIDEKTKNYLPFKNQVRSNGKEKELSTFSEEKDYDYDAFLDSEEEAFYSNDGGAFGMNTEPRVLIRSRRETTPRKCAVVEEKPAPTTPPPPTDFPPVKPQVFNASSSLNYSFDTNLFTCLFWNATTESWSTNGCQPHRNSTPTLLICMCNHLTSFGADMLVAPNPIDFDEVFANFANLGETGNFSVMFTIIGLFLLYALAVVLARRADKRDVLLVSKTRVGSIDPRCGGQNYEIAVSTGTFRGSGTTANVALTMIGEKGTSQTIPLVDETGSSEELLSRGNVAYLMVNTPEDIGDINYIRIWHNNKGNDPAWFMRQITIRDVVSNKKWFFLHNDWFAVDRADGKIDRRIYSASESEKSKFKTLFYSHTAKSFSDKHLWISVILRPPSNPFTRVQRVTCCLSLLLCAMLANAMFYQNGGGSEDTLKVGPFKLSLKQIIIGIESGLIVAPVNVLIITLFRKARPKTKAAADQMDDTKEKYSSPKDQPNDGKKRNDKSSKSDPDNTNKTRKEKVKKKGFPHWCIYIAYFLCAISVLVSATFVLFYSMMWGTEKSNEWITSVLLSLIQDILLIQPLKVVILAMILSAIFRKPPEEDPEEELDTQQQKSEQQTPKDFGTSSDIFKFHDINPEQYEPLDSEKVEDAQDYQNKRNTLRSTIKEIVWHLVFILLVSVAVFGSQSSHRYKLHDHLDKVFSKTEQVTTADTFWSWCETVLIPGLYDNDWYNDRNFTDERGGFISNKKGLLISMPRMRQVRVKAEECTATRDYPKLHEMFPKCYSDYSMSKADESSPLTSSNPQASTLNDSILSGEIGFERMCLQPFMVQSADKLGTLPLVTDDATYSGSGMVADLGYDNSTASEVIVNLKADQWITRQTRGVFVEFVIFEPTSKLYAFARFIFEQKSIGSFFSSKSIEPYALYGTGSSALDSVILAIQFILIIFILVCLVKEIIKMVKLKIPYFKDAWNIHQLLMLGFTIGLVVLTLVRDVYVANLIKTIQDNPYARMSFDYVKYGTDVWKTMASLVVFLATLKLLKLLNFNKKILTFVQVLKLSRPFLTSYAFFFFVAFSAFAQCGNLIFGQQLLMYSNVMRSFVNVFQMALGKGLFFHDLKDITATLGPLFILCYFFVTTILLVNFFVSILNDSYADGSKKIEDDTNEEAIMAAFMSAYLKSSLKDISRDLKQMRSKPGRGRGRRLKGQKEMAKTREEKRLKQLENEVSYFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYK0</accession>
    <name>A0A6P8IYK0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Forkhead box protein O-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571028.1">
        <property type="nucleotide sequence ID" value="XM_031715168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYK0"/>
    <dbReference type="GeneID" id="116305288"/>
    <dbReference type="KEGG" id="aten:116305288"/>
    <dbReference type="InParanoid" id="A0A6P8IYK0"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF9">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="200"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="200"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571028.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33325" checksum="DBF0393DE6998B92" modified="2020-12-02" version="1">MQNRRRVGESRKKMYEIPPSVDWYLRVSSKSRIHYPAVYEESSNLGGSESSYSSSKDKEKSPKQPAQSGLNSPELERRYSPSDLTRKRKFEEFEDDLGRKRPKKLDQLNSINCQARTYPHRNLESCLSRPTTELKSIISLQQQRAITQEQPRGQNKEDFQKIQELVKKFPEIRPKTNEESNLVYKPHNNSTRKNPWGGESYSDLIASAIRSFPNNRATLQQIYEWIVGNVPHFADKADYPSTKGWKNAIRHTLSIRKRFTRIINDTSPHSSLWTFSKYSYKTTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYY5</accession>
    <name>A0A6P8IYY5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572384.1">
        <property type="nucleotide sequence ID" value="XM_031716524.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IYY5">
        <property type="interactions" value="710"/>
    </dbReference>
    <dbReference type="GeneID" id="116306457"/>
    <dbReference type="KEGG" id="aten:116306457"/>
    <dbReference type="InParanoid" id="A0A6P8IYY5"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003553">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572384.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24571" checksum="02F9894BF83CDB7E" modified="2020-12-02" version="1">MQKTTPKKKADLKIVILGESSVGKTSLIQRYIDRVFTEDQISTIGASFFLKQWGPYNVAIWDTAGEEKYSGLSSFYCRGAAAAIIAYDIXDGQSFSVLQNRHLHLLQTAEPNCLVVIVGTKLDLVTKENRGVSKEAGQELAKRQNENKHRPLESLTEIPFFETSSKTGHNVDKVFQYILENCLPLKDQATAKQYLRKSSGIELEASNAASSKGGNSGRKCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZA5</accession>
    <name>A0A6P8IZA5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571125.1">
        <property type="nucleotide sequence ID" value="XM_031715265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZA5"/>
    <dbReference type="GeneID" id="116305371"/>
    <dbReference type="KEGG" id="aten:116305371"/>
    <dbReference type="InParanoid" id="A0A6P8IZA5"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="26"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571125.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62608" checksum="982E9D350E6D288B" modified="2020-12-02" version="1">MEASAIHRHQNIRRLKGLLYIENRTLRFKAFYLVFFFGCGTLRNYLPVYFRHIGLNAVLTGVITGVRPFTGFISAPFFSFLADKTGCYKSILLLSLVMSVLAYFSLSFVAFVQQAKEVQPIEHVIKSNITLLQRNSIKFSTSYTTRDRGFSFGGNHHGNDRLNYPLPNHTNMGITQLDRSGKNPRHGPQFADSGLYYANESLVPLNDTSILSESMIFFASFGLIVIGDFFNAPVGAIMCSTIFYWEGSSQFGKQRVFGAIGFGLGSFLTGMAIDKTVGFNYFQLNYLKNDGSNESNPNYLTAFFLYLGVNSILLMFVSCGLDVSRESKSKIIMTHVKKILSRGMVVCFLIYIFIMGVVGGTIMLFLFWFLENLGASQSLLGLSSAIMSISEVPIFPLCAKMINAIGHVGVLFLSLTCSIIRLTCYTFLQDPWYVLLIEPLHGISLAAMWSTSISFACAVSTPDVYTTMEGVTTGFHYGLGWGLGAVIGGAFYNLYGPRNLFRWCILLCCVGYIFLGLVYILQRKDHSSVNYYRLDNNRQGSVNVDAEYEVISGDIYLNTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZI4</accession>
    <name>A0A6P8IZI4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572582.1">
        <property type="nucleotide sequence ID" value="XM_031716722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZI4"/>
    <dbReference type="FunCoup" id="A0A6P8IZI4">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="GeneID" id="116306642"/>
    <dbReference type="KEGG" id="aten:116306642"/>
    <dbReference type="InParanoid" id="A0A6P8IZI4"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572582.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39169" checksum="295B6B89EBBAC17C" modified="2020-12-02" version="1">MACCTETEDTLDSLSREAEQLKIRIEEEICKYHDKELKNVAERLQSLQGCHMKVRRILKGHQGKVLCMDWSGDRRHLVSSSQDGKVIVWDAFTTNKEHAISMPTTWVMACSYSPSGSLVACGGLDNKCSVFKLSYDDAQNAKKQTVAMHTSYMSCCKFANSDHQIFTGSGDSTCGLWDVESNQLIQSFHGHYSDVMSLDLSPSEGGNIFISGGCDKKAHVWDIRTGRVINSFDDHDSDINCVRFYPGGDTFGTASDDGKLRLFDLRADHLLSTYYKDHVIFGAASLDFSISGRILFAGYHDYTVHVWDTLKSERLAVYYGHDNRLSSLRVSPDGTCVCTGSWDQTLRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1L4</accession>
    <name>A0A6P8J1L4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116305819</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571650.1">
        <property type="nucleotide sequence ID" value="XM_031715790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305819"/>
    <dbReference type="KEGG" id="aten:116305819"/>
    <dbReference type="InParanoid" id="A0A6P8J1L4"/>
    <dbReference type="OrthoDB" id="10615135at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571650.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33574" checksum="D60A93F0F2AB54FE" modified="2020-12-02" version="1">MIFTLSAPLFIQFSALTSSFFLFKPKMNGKSHFLVTFIMFGSLASYATARALRKASQEVLHPYYPTARSTDAYARFVHSCLFDDEXSNKTDPKADDTDRKTVTMKANRNAYAFDINTCLFNGWRPGVLSSSVQCNGGTELCYSVSPPTAQFAVCYDTIKLIPIFTGHVLRFSALLGGGARASNPPWKENQNTKGGIVYGSTAVKLKGRVTAPKYYWKAVCDPAARGSILFVAENNVNVMTTTRITGCNGISQTSENGVVXCYALDAAKSNPDFQDFQLPPLDKKNCNPANRGTFMDHIIRSFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2C5</accession>
    <name>A0A6P8J2C5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116307932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116307932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574121.1">
        <property type="nucleotide sequence ID" value="XM_031718261.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J2C5">
        <property type="interactions" value="1699"/>
    </dbReference>
    <dbReference type="GeneID" id="116307932"/>
    <dbReference type="KEGG" id="aten:116307932"/>
    <dbReference type="InParanoid" id="A0A6P8J2C5"/>
    <dbReference type="OrthoDB" id="5978964at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028461577" evidence="4">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="89"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031574121.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28838" checksum="2738506FF58038E7" modified="2020-12-02" version="1">MNTMSSKFLIAIFFLACAGVGFQTTEGSVFVHPYYRFHSFWPDFDTFDDDFFSDPFFRTFRDPFDWDPSRDDIVDFPILRKPAIGNQRNCLPKPTPRKSLVKPSEELKLSIDVKGFAPQELTLVTXGNDVIIRGEKKDCDSTSCYTRSLCWRKKLPQDIKINTVKAKLTKDNIVEITGEKKKEIAAEANTKIERETQEKLTPQKSGKQEQFTKPSDLPMKNQNSMKEEIPKPKPVDEAEEETTLEVVKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3F8</accession>
    <name>A0A6P8J3F8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Metalloendopeptidase</fullName>
            <ecNumber evidence="14">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116306207</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031572120.1">
        <property type="nucleotide sequence ID" value="XM_031716260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3F8"/>
    <dbReference type="FunCoup" id="A0A6P8J3F8">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="GeneID" id="116306207"/>
    <dbReference type="KEGG" id="aten:116306207"/>
    <dbReference type="InParanoid" id="A0A6P8J3F8"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="7 13 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027991033" description="Metalloendopeptidase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="17">
        <location>
            <begin position="50"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="16">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031572120.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32389" checksum="441CA3BAB12BA0C5" modified="2020-12-02" version="1">MKWIWALAFLVVVAASNPEEEDIDPDVFEGDMILTPEQKAAALSGGDVDASVSRGSTKGRQWPGGVLAYVIDGALARDSRAMAAINGAFREWSSKTCITFKKRSNEQAYAYFKIGSGCSSYVGRTGRRQDINLARGCWHVGIVAHEIGHALGFYHEQSRPDRDNYVTIMWDNIVERNKFNFNKYNRGTIDSLGTPYDFGSVMHYGGRAFSKNGKPTIVAKKSGVTLGQRRGLSAIDARQMNLLYKSQCGGGGGGGGGGGGGGGGSSCVDKDNRCRGWTSYCSYHRYVRANCKKTCRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5B8</accession>
    <name>A0A6P8J5B8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308553</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574867.1">
        <property type="nucleotide sequence ID" value="XM_031719007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5B8"/>
    <dbReference type="GeneID" id="116308553"/>
    <dbReference type="KEGG" id="aten:116308553"/>
    <dbReference type="InParanoid" id="A0A6P8J5B8"/>
    <dbReference type="OrthoDB" id="5980977at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028025907" evidence="1">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574867.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25249" checksum="57A4E84B42553EE0" modified="2020-12-02" version="1">MNRKIILNLIAICVALVQFADSAYQVHKNTPIPVYTSKSPVIIPQTKLGFRSNLGRNVFFGYMLYRYGLMEAPVYRGRYPIHRSTVEIPDERAIRVNFTKEIMLDSNGTICLNSTKSYTIAPNKSVVLTSVRYSNIRGGLSTEYFGDNRTVTIDMNTLNQTVEITTRVLYRGTIVANTSCTQVMSVMNGTIVRMYATNPNADTSAAIASVQSSFLALILSSLIYCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5F3</accession>
    <name>A0A6P8J5F3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 330 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116306732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOA36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572685.1">
        <property type="nucleotide sequence ID" value="XM_031716825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5F3"/>
    <dbReference type="FunCoup" id="A0A6P8J5F3">
        <property type="interactions" value="1463"/>
    </dbReference>
    <dbReference type="GeneID" id="116306732"/>
    <dbReference type="KEGG" id="aten:116306732"/>
    <dbReference type="InParanoid" id="A0A6P8J5F3"/>
    <dbReference type="OrthoDB" id="10258894at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010531">
        <property type="entry name" value="NOA36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13214">
        <property type="entry name" value="ZINC FINGER PROTEIN 330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13214:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06524">
        <property type="entry name" value="NOA36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031572685.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36072" checksum="202EEAB5EDA04A73" modified="2020-12-02" version="1">MPKKKTGARKKAEKQKARQKCIQAGANWSLMEKPCNAMMECDKCKRRQKNRAFCYFCHSYQKLTVCAHCGKSKCLMKSGDCVIKHVGTHAVGLNMVGAICDFCEAFICHSKKCLTTHPCECPLRDADCIECKRVVWDHGGRVFLCAYCNSFLCEDDQFEHQASCQVLESESYKCGSCNKLGQYSCLRCKVCFCDDHVRRKGVKYTRGQAFPCPKCGNETKETKDLSMSTRSHTYGRQKFDDDDDEEYSGGFSFGGYSFGGASAGYSYGNDEDDYDDEEDEEEEEEEEEEEDDEEEEENDETKEIQTPLENIKLANKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5F6</accession>
    <name>A0A6P8J5F6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308597</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574917.1">
        <property type="nucleotide sequence ID" value="XM_031719057.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J5F6">
        <property type="interactions" value="1229"/>
    </dbReference>
    <dbReference type="GeneID" id="116308597"/>
    <dbReference type="KEGG" id="aten:116308597"/>
    <dbReference type="InParanoid" id="A0A6P8J5F6"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574917.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18118" checksum="D9437C86B6A1F7E1" modified="2020-12-02" version="1">MPPKFDPNEIKIVYLRCTGGEVGATASLAPKIGPLGLSPKKVGDDIANGTKDWKGLRITVQLTIQNRQAKVSVIPSASSLIIKALKEPPRDRKKVKNIKHNGNITMEQVIDIAKTMRPRSMARKLSGTVKEXLGTCQSVGCTIDRQAPHDVIDKINDGEIEIEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5L9</accession>
    <name>A0A6P8J5L9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116308663</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574997.1">
        <property type="nucleotide sequence ID" value="XM_031719137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5L9"/>
    <dbReference type="FunCoup" id="A0A6P8J5L9">
        <property type="interactions" value="2154"/>
    </dbReference>
    <dbReference type="GeneID" id="116308663"/>
    <dbReference type="KEGG" id="aten:116308663"/>
    <dbReference type="InParanoid" id="A0A6P8J5L9"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031574997.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13481" checksum="F6F3A8D1A6B4EC86" modified="2020-12-02" version="1">MSGRGKGGKAKGKAKSRSSRAGLQFPVGRVHRFLRRGNYAARIGSGAPVYMAAVLEYLSAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGSVTIAQGGVLPNIQAVLLPKKSEKKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6F3</accession>
    <name>A0A6P8J6F3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HIG1 domain family member 2A, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116308960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575334.1">
        <property type="nucleotide sequence ID" value="XM_031719474.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J6F3">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="GeneID" id="116308960"/>
    <dbReference type="KEGG" id="aten:116308960"/>
    <dbReference type="InParanoid" id="A0A6P8J6F3"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF18">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="21"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031575334.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12622" checksum="F96AF0F0D75C75C5" modified="2020-12-02" version="1">MILWEPCGKTKMAPIEPEKKEKKIPRWEPPTRDETAKEKFARKARENPFVPIGCVATVGALGYGLFSFLRGNAKMQQSMMRARVLAQGSTVLAVIAGLGYELYXRNKKPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JA60</accession>
    <name>A0A6P8JA60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574628.1">
        <property type="nucleotide sequence ID" value="XM_031718768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308365"/>
    <dbReference type="KEGG" id="aten:116308365"/>
    <dbReference type="InParanoid" id="A0A6P8JA60"/>
    <dbReference type="OrthoDB" id="5959851at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="245"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="326"/>
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        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574628.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48458" checksum="B25821BFE4A7B01F" modified="2020-12-02" version="1">MAYNFRPSRPKASVNPKRTAKRESVFQVERGPISNQKRDVQQLDEFRNRSFMQRGCNNFRTTSQRSGLTIGEQEIEKCSSKTTDSSSSPGYQTFCSVQTLPSVDKDXLAAKFTPRCFEYVQNYHHYILDLNKLEKGEQVPYLSRMENKNTLNSFKNEGRTTKDKYHTRNGSKSSSSNYFSGLPRRAPKSASLSRRGSAGNGNKTDLNLMVNNFPSTQSQRGEEDSSRGAGKKAEDRKDTEDNTLQDLIISEIEDELDDGRAKESTSEFSNFHVDSIYQYPNPSTTDLRVPSGTPVTTPRSSSVQHSFPNLPNNWSSDKTTTNGSLQGVSSEVRKPYLSAFTTRMPPLKAPDISLNEERRRQRNTYMPDYQRYRILCDAFRPLSPQGGRGRRQIDRHRPNFVTSEELDYYIDVVNNINAVHAYYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JER5</accession>
    <name>A0A6P8JER5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308567 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574890.1">
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    <dbReference type="GeneID" id="116308567"/>
    <dbReference type="KEGG" id="aten:116308567"/>
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    <dbReference type="OrthoDB" id="10329601at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <begin position="177"/>
            <end position="202"/>
        </location>
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            <end position="320"/>
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            <begin position="712"/>
            <end position="756"/>
        </location>
    </feature>
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        <location>
            <begin position="965"/>
            <end position="1009"/>
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    </feature>
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        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574890.1"/>
        </source>
    </evidence>
    <sequence length="1018" mass="114546" checksum="81E5FA25F9890133" modified="2020-12-02" version="1">MWQRKRMELWTKAVEEQLSIRRRSSHHLQQDSWTSTRMALNYNPDYRGFPSQIHNNREATNPARCCCDTCSLINAQEMDRYYTAQGQPPLYLTSWPMVMQPHSHKQGLYPAQGSYLQPQYQERSQPPIHPRGAPLIFTQPTHLERPFHPPIPTEPQHIQHPACYPESRTYPLTEIHNIPSDLSPPPTFKTSTTLTSKGSISSTPLRPGGVAYDHHDLPKIVSVHSLPSSPVFVSEQLQGATLLPLESKLPTVYAEESACSDTITYPRSSPKVCLENRYSSIDPKTEYTLAETEKTSDPSEKTAEYMKIEDNDKDQSTKSLDKCEAVSPNAQLPESPKYYMAKHQNEAKTVTNVGQEEAAQPKDVIDREMMIRRLLRMINAWQIDFNQETDDIKKFKILNQILEARAKLEKLRLNRDGTNTPKARELPTDGGKDSSKVNEVTVGIVTKNEDVEETTMETKNDIPRTSSNFESMSDFVTSRNISSETRMKSPNITMETAPKITMATKSDKVTATKITKDTPSDGAAPPKITMETESDVRMLSPEINMETEIDGEETPNATMETNSNSAEQESDAICTNMTSSFCAETNTSSIMETNTDVVSNANATITMTSTNATMITSNSNIGNKTDTMRVTVDNDPSSLPEDSASLLSSFANPCQTSPKILDKTTLLQPRILVNLFDRVKLFDRRKKLVGPDETSPEKPEDQEENYCAKNMMNREKNSSNNASASENSISDKKHNQIDGELSTNREGSQRLSPGLSNIIKDPLATTEIRRKKHAGDCKVTESDSDDVWTMELDESSHKAVFRRRWKRTGGPSDQKRSAFESLLTDGTEIQGLTEGKEWFSRLPESSPPPKKRALLELRIIEDEDEVDDNDERIINEAIKISPIFKTLASGRLKRAIQSNQDPTSSIYPTDDIDRPTQDLLLSDLEVSDSPSNENSLYSQDGGVKEMAALSGDDGEENIFIPERSSQLRESKIHRLNEKKEQLLEELKQIHRLNEKKEQLLEELKRIKANPPSSVPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZD8</accession>
    <name>A0A6P8GZD8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116286489</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548878.1">
        <property type="nucleotide sequence ID" value="XM_031693018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZD8"/>
    <dbReference type="GeneID" id="116286489"/>
    <dbReference type="KEGG" id="aten:116286489"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027842499" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031548878.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11804" checksum="3691E46DFE64B6F2" modified="2020-12-02" version="1">MFPPKSLVLTLVISMLICMCVCRPSMEARPRAYLDNASRFRRSGEINPCVKSRKIDAKTGIKIAECYESSPFGCTQNVFKTGSTLCKPVVGKTRNGNHQTIIDCVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H082</accession>
    <name>A0A6P8H082_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microcephalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="interactions" value="1550"/>
    </dbReference>
    <dbReference type="GeneID" id="116287302"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17736">
        <property type="entry name" value="BRCT_microcephalin_rpt2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="807"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="911"/>
            <end position="991"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="805"/>
        </location>
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        <location>
            <begin position="65"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549829.1"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112115" checksum="7574307CF6BF3C47" modified="2020-12-02" version="1">MDKKRASLGLNLSSKKRTTPENKVFSGFHSPVSNKSTSLYKNVLKDSVGKQASSHSKVRFSLGDSIKESPREQKRNEEFDFHCSFESDEENSXNISFSCTQPVSQDAILQGVIAYIEARSNTENRFEGISKQMELLGAVVVKKFIPEVTHVIFKDGKKSTREKALKKGIHLVNVLWVESCRESGKRVPEDLFPVVDEVHTPLVTGKLKRTKSMQPRAFEDDVRNSAERINRKRQRKIASERTPTSILSPLTLRLLSEXSPAPASPLVSSSMKHVPDTAVYSEPNSPDHKDRDSKETEVPSKRLNFVDTPLGSPLSAPVKTPVSPKTIPTDILQTASGPGKKRKRLLSSKDSTPKEPDEKPHQNKKSKPAKTPHENTDVFTFDEEEVPDVKTSKLKRTRKPRSKSTSGVETMIEEESSCAAREDELENNLXANSLAKKTKGKRISSSKQEDAQLKSTSGKGSGSRDVERDLDNLVCATGLSDSGVSFSEVEMQEKKTKVLKKNKRTSEKTEKXVGEVVSTEDENELEDVGKKTEPLKSKKKTESIAKKTSDTKRGKQSVSKKKNEKKTMELTRDEDKKLPGDICNTAEDDDGKKNDAKKMKAKLDKNDSRRKKMYRKNISKVSDDEDDVIDDDXGGNDDDYTGNGKGKCNFSRKKPVRKTIPNTDDEDDVIDNNDDGDDDDDDNGKRKNILRRKRSVRKTILDTDDEDENDIVDNNHEDGDYDDDDDCRKKDISRKTKPVLKKIFDDTDDDDDDDDGNDDRSTEDDGDKSDIHDGDYSEEDVSHKSNEKQNNGKQKTKEKKVVRKKPPRSLVLTSMHFSEQDIVISVVRKLGGFYIADTVGPSTTHVISGSPRRTLNVLMAIAQGNWLVSPEWVMKSLETGYWVDEEPYELADAFPSAQLSRLERVSSGPDYHQELFAEVDPIFVSDNTSPPRETLIQLITLCGGKICTSIRKAGVVVGTISRKTKTINVSERWVLDSITEHTALSFDPYVFNPTKSNSPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3Z2</accession>
    <name>A0A6P8H3Z2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Layilin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550278.1">
        <property type="nucleotide sequence ID" value="XM_031694418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287730"/>
    <dbReference type="KEGG" id="aten:116287730"/>
    <dbReference type="InParanoid" id="A0A6P8H3Z2"/>
    <dbReference type="OrthoDB" id="5976046at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550278.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26145" checksum="EAD879F10AB8689D" modified="2020-12-02" version="1">CFCYKFNTHELGWREGRGECRKDGGDLVTMETEEKWKFIKSKIQGINKYPNEWYIGLKKEGGEWKWVNEQILSINKWQPEWNSNIEPNGDGECVIMAKNXPPGTQGLFKDLTCKYALMFVCEYRKGNPRCKDGYYPPRCNETNLGTTSVEPTKKTIAAATQLTTTFKKQRTNQSNSYIHRVSLIWTSEYSKMTNENGSMYKGGFCDNYCQKMAKQKYNCCRFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4H0</accession>
    <name>A0A6P8H4H0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Gamma-sarcoglycan-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116287778</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550331.1">
        <property type="nucleotide sequence ID" value="XM_031694471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4H0"/>
    <dbReference type="FunCoup" id="A0A6P8H4H0">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="GeneID" id="116287778"/>
    <dbReference type="KEGG" id="aten:116287778"/>
    <dbReference type="InParanoid" id="A0A6P8H4H0"/>
    <dbReference type="OrthoDB" id="5973998at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039972">
        <property type="entry name" value="Sarcoglycan_gamma/delta/zeta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939:SF10">
        <property type="entry name" value="EG:4F1.1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939">
        <property type="entry name" value="SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550331.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30927" checksum="16CD57A451DDDD55" modified="2020-12-02" version="1">MARDRVETSELDWSNLQDPNKIVYTIGIYGWRKRCLYFLILLIMILAIINLSLTIWILVVMDFNSDGMGKMRITDTGVKLYGHAEFVESLHANEIRASYNKPLLVQSTNHLVVNARDGNGNITGQLYLGGDQVVAKNKYLRIKTDKDKEILYADKDKIVFRSDKLEFSSPYGAHFTGSVETPTVRSPPKQHLTLESLTQSLHMNAPEEISMKAVAGGMTLESLTDITMTTKGKITLDAESVTFKNLKPSGSVKNNACELCVQPDGSLFLGSSGCSNLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5E9</accession>
    <name>A0A6P8H5E9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thrombospondin-type laminin G domain and EAR repeat-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551594.1">
        <property type="nucleotide sequence ID" value="XM_031695734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5E9"/>
    <dbReference type="GeneID" id="116288870"/>
    <dbReference type="KEGG" id="aten:116288870"/>
    <dbReference type="InParanoid" id="A0A6P8H5E9"/>
    <dbReference type="OrthoDB" id="5965730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009039">
        <property type="entry name" value="EAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005492">
        <property type="entry name" value="EPTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15261:SF4">
        <property type="entry name" value="THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03736">
        <property type="entry name" value="EPTP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50912">
        <property type="entry name" value="EAR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027761723" evidence="5">
        <location>
            <begin position="21"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031551594.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="62697" checksum="D86AD5A61CB32980" modified="2020-12-02" version="1">METRMFVTLLLIAGLSFVQMEESSKTTESNPLLSHSVAKDLTTRSMVTKNNDDNEGSSGSGGSGGSGGSGGSGGSGGSGGSGSSGSGGSGGSGGSGNGGSGGSGSGTCLCKAGKDGRDGRNGTDGKPGEKGQVGPKGEKGEQGDKGDKGERGSPGIRGPRGEQGLRGPIGKTGSCTCSVKKKDLNDLKNKYSSIMKENKLLNQKIQEMQLKITGLVNKNETTSSFGLFEKVQNIPTKGAISVEAFQIDGTTFVVIASNYHNNNPQDKPVSTIYKMTASGLTVYQNLFKINRAIKIRHFDMDGQHFLAIAIVQNTITGMYSTNSEVYKWDGKQFVPFQKIPTVGGRDMKYFTIDEYKFLCVANSYNGITTAISSTIYKWNNYQFVLYQSIFTTGATACSAFTIDGQHFISFGLTSSNFGSVINKLPVLKFSGIKTGFVAFQTLGSLVASDVTYFRIRNNHFLILANKATQGKHNVHSFIYKWNGASFVRFQNMETFGATGVRSFEINGETYLGISNSYNDLTISNVVESVVYKAFGSMFAVYQRVPSVGASGMDFFNYKGSTYLVIVNYRHGNNIHLMSYLHKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5Z8</accession>
    <name>A0A6P8H5Z8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Secreted protein PRY1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116289051</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551798.1">
        <property type="nucleotide sequence ID" value="XM_031695938.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551799.1">
        <property type="nucleotide sequence ID" value="XM_031695939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289051"/>
    <dbReference type="KEGG" id="aten:116289051"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="174"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551799.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="35644" checksum="44D12F2244A09874" modified="2020-12-02" version="1">MPNKFQKECLNAHNAYRAQHGAPALKWSAKLASDCEKWARDLAKRNALQHSTGDYGENLAMASGYDLSGNRSAEMWYEEINKYRFNNPGFSSGTGHFTQLVWAGSRELGVAKAASSSGAQYVVARYLPAGNVIGAFPANVKPRGSKVDKAAKAGGKDAARVTSKTSDKPQSSREFKNDILQAHNQYRALHGAKPLKWNSKLASEAQSWAENLAKRNCIQHSSSRDYGESIAYMSGAELTGHKATDMWYEEADKYRXANPGFSSGTGHFTQVVWASTTEMGAGRATSSTGAHYVVVHYTPPGNVMGQFPENVKPRGSGNPGGGGKSCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6M3</accession>
    <name>A0A6P8H6M3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288483</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551141.1">
        <property type="nucleotide sequence ID" value="XM_031695281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6M3"/>
    <dbReference type="GeneID" id="116288483"/>
    <dbReference type="KEGG" id="aten:116288483"/>
    <dbReference type="InParanoid" id="A0A6P8H6M3"/>
    <dbReference type="OrthoDB" id="10437637at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028006676" evidence="2">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551141.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20570" checksum="EDF8FD9CD4905A69" modified="2020-12-02" version="1">MKLLPVFILLVVPFQSNADNTGGGPKSVYSCPGSDVDLKFNTPGPITRSHLVGTKGGGIDANPLNMSVWISNNFKTEVNATAGNKVEFNGNLFAGHAWFKFKNFKPNDRDMIFRISTYKEFGTSPSKQDFKLILSKDCAQQKNSSAGNSTSVSSNSTANLVPLPPEKTTPNSKGESYPDGTSPDNSILSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H951</accession>
    <name>A0A6P8H951_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Probable G-protein coupled receptor 158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116289301</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552051.1">
        <property type="nucleotide sequence ID" value="XM_031696191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289301"/>
    <dbReference type="KEGG" id="aten:116289301"/>
    <dbReference type="InParanoid" id="A0A6P8H951"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12913">
        <property type="entry name" value="PDC1_MCP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF29">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028206275" evidence="19">
        <location>
            <begin position="26"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="20">
        <location>
            <begin position="414"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031552051.1"/>
        </source>
    </evidence>
    <sequence length="815" mass="93243" checksum="00D556CE51CF02FA" modified="2020-12-02" version="1">MIKMIRSVLALFMIGTVSLLVKLEAVTVNATVDNHLQKALRFVQAVQNQTKCDKVVYLDVLLDQQRWTKEAFLVLEVANLMTSLWMSRSQSNRSIVEDDAFLYHSVRSIVMFSPPSFGSVICFDRNKYKDYYLFCPYAFKPPNRNNTIKVFDIASQDGGYDYTTDDNAIWWRDTKAKAINLFPANQTEIYAVRLNATTHEKERSYTISIVRYSDGIWTRPYFDCFGGKIWMVTYLAPFFDEKSQFLGVVSIDIELMDIDINQCDXSQTDEDRRSRMDQVAGGGNSERLVEFLGTHRCKSTTTKCVHIPHQGFVRGSYKCECREGYYFPDVEAKERFFKGTDVEGAYDDFLERKNQQYDTGFECLKCSEGCQECIDAXPCTYSNNLLLRIFLAVVNGFVLLMTIGFGXSSPRFIIITILGVIMMYIKPFVDLSNPTNILCIVDQWLHHLGFAVANSSIIIKTWRVAVIFRVRSAQRMALTDAVLLRRLLIILMGYVIYMLFWTNINPPTVSQWKTSDGLMFDRCILNEWLEVIAIVGDLGLLSVAVIFRVRSAQRMALTDAVLLRRLLIILMGYVIYMLLWTNINPPTVSQWKTSDGLMFDRCILNEWLEVIAIVGDLGLLSWGMLVCYRVRNAPSAYNESKFVSWAIYNSMFVTCFSTVLRFTIRNSTNPDVMFALEFVFIHTSATTTMLLILVHKFVHIRKAKQVINDVTSIHNASGAGNNVRERVHMTEDNQPINXECEELRGEIQRLSNQVANLQAKLLQEKNNSTPQRRESRLKCLGFGSVEKRKTTVTATTSNTLNEDQLDDKPSVIFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H984</accession>
    <name>A0A6P8H984_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentatricopeptide repeat domain-containing protein 3, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551758.1">
        <property type="nucleotide sequence ID" value="XM_031695898.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H984">
        <property type="interactions" value="2584"/>
    </dbReference>
    <dbReference type="GeneID" id="116289022"/>
    <dbReference type="KEGG" id="aten:116289022"/>
    <dbReference type="InParanoid" id="A0A6P8H984"/>
    <dbReference type="OrthoDB" id="6021531at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031551758.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28179" checksum="19A6D40EA00A2957" modified="2020-12-02" version="1">MCSKGIEPSLATFSRVLRAEXYRDRSMAVYENEDEGDLKLKQNTNNSVLQAIISHLETYDKLPGLKHSSDIKFFNTAMGSALFCQDANAAHRLYALAETNDKTLLGQKRGLFYATFLVTLAQSEKSAEIVYHMYKELVPAKLIPQSWVYSELFRMVEREKMPRLVPKLYQDMKRYRVPINEQTCRGIFSALARRTSPKNHKQYIEIMTDVFFWMKKFNIPISPYMIGQLVRQYCAGGHLKQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAQ9</accession>
    <name>A0A6P8HAQ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane emp24 domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549580.1">
        <property type="nucleotide sequence ID" value="XM_031693720.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HAQ9">
        <property type="interactions" value="2470"/>
    </dbReference>
    <dbReference type="GeneID" id="116287105"/>
    <dbReference type="KEGG" id="aten:116287105"/>
    <dbReference type="InParanoid" id="A0A6P8HAQ9"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027670098" evidence="10">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031549580.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25445" checksum="6BD51FB3F2691AC2" modified="2020-12-02" version="1">MRALXILAFIGYLFTSTNGLYFHMGETEKKCFIEEIPDETMVIGKYKTQLYDENTNSFLPSSPGIGMHVEVKDPNQKIIMSKYYASEGRFTFTSHSPGEHIICLHSNSTRWSLWAGGRLRIHLDIQVGEHTNDYAQIAAKDKLTELQLRIRQLLDQVEQISKEQNYQRYREERFRQTSESTNQRVLWWAIAQTFILLTTGFWQMRHLKGFFEAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HD01</accession>
    <name>A0A6P8HD01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transforming acidic coiled-coil-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554284.1">
        <property type="nucleotide sequence ID" value="XM_031698424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HD01"/>
    <dbReference type="GeneID" id="116291270"/>
    <dbReference type="KEGG" id="aten:116291270"/>
    <dbReference type="InParanoid" id="A0A6P8HD01"/>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057663">
        <property type="entry name" value="TACC3_Aurora-A_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25777">
        <property type="entry name" value="Aurora-A_bind_TACC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="654"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="674"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554284.1"/>
        </source>
    </evidence>
    <sequence length="865" mass="97371" checksum="54059FF620FDCD66" modified="2020-12-02" version="1">MSSSLLEEKENVNIPNEFAKEGKTTTKSSILKPSQRENVSSVQQLTPQKPPKVTFKNTPVHYRPACYKVELTQSQLDTWEEIRSLDELENWTERTQVVTKEDHQIHLEAAREFLEDIINNLPCIKSPEAQAEKTVKSEDIKEKSPSKVVEPVETKQECTSSVEENKSVSKVIPDKIMDDGFDNDSAGPLDPAIASLNSLLKAGEDEERAFSPIGSERTSPDCDAMVTSEDIEKLLAKNDFQDEGEIPPLELSHGSKFDKMMDLQFGGKSLEEMTRKLDQLRLMSPKIDIGINQTEDNDEDSLPVKRRGAKPSPGKETQDTKDKKENTEEKENIPDDEDFSLPVKRREPKAEPKKQTDTNGDSEKFKKPLPPKPWKTKKVKIPKEEDPFIVVLPGAGESTVNGNNVNAGVDLPKNGSSFAEPKPQPSDSGASQGENSQGENTSDSVIKSQEETEKQPSLKNNENEEGKNKNASVQDDVFLEKQDDFGLENDDFKSSSEAFSLELDYLEKFGNTDNLDRLSALARQSLYVKFDPLVKGSPDQDLKQMKADAINSKQTPPGNFGDLLLMNTPPNRRAQQRLTAIKEAKGKDANNLSDVDKLLTFSPQAKTSNEDSSKQSFEPPKSTAQDNHSDESHDPSLVEPLLYSKSDIAVAVKKEREALLKQTHEESAIRDMEIQEIQSKLQAEVEGNAKLRRENDELRTVMNEYERTLAEMIETSEKNKNMSDESKNEIVKERDQLQADLNSVEAAFSDLHRRYEKLKGVLENYKKNEEILKKATIDYQEKLKKSGEKYQMLKKHAEEKIETANIEINRVRRSNDSEMAVMRAALKKEQNKCASLEQAIQQKINENKELTAICDELIQRASGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDW0</accession>
    <name>A0A6P8HDW0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550827.1">
        <property type="nucleotide sequence ID" value="XM_031694967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288179"/>
    <dbReference type="KEGG" id="aten:116288179"/>
    <dbReference type="InParanoid" id="A0A6P8HDW0"/>
    <dbReference type="OrthoDB" id="5964095at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550827.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30024" checksum="5CA1C535B02927EE" modified="2020-12-02" version="1">MSERSVHSYEPRFAYYVNSVSDLDHKVVLAHKGEDSEKQKQLLXQGEKNHYDVYVCVDHGLHGFVLIVPCGDPYANLLYKGLMEDNPYKIPGKLFCRKFELRFENMKERMYKISKSVTVFEKIEKYTKKFYYVGRYADVPLPGLDLAASRAAPQRRETLLNDCVEFAKEYCYALLSYCSNGLEIEKEVKSNIKKATASGFTVEKLSRQSYFSGLMGNFSFGGANVTSFLAGQHGAILLCILMLFFFLWPIVVIVLAKXYQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE81</accession>
    <name>A0A6P8HE81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cubilin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550957.1">
        <property type="nucleotide sequence ID" value="XM_031695097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288318"/>
    <dbReference type="KEGG" id="aten:116288318"/>
    <dbReference type="InParanoid" id="A0A6P8HE81"/>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF37">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028309725" evidence="5">
        <location>
            <begin position="21"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="152"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550957.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44899" checksum="3285A3770FBED37D" modified="2020-12-02" version="1">MELINCFLLVIIVSSSVAAASDCGKLTNTSILSGTITSPLDTSNKSCQWNIELPPKYTSLQIRIHDLNLRNCTNCSCDYIEVWNSQTKDPRHWVGKFCGDLKDKYIEIKQTNHLLVEFGSSYWSGMKSNHTFLSYRGSEVPVSQTSPTAADCGKITNTTMDYGTITSPINTTNKKCLWHIQVSARNTEIXLDFNDLKLMDCPNCSCDYIEVWSSRTKNPQQWIGKFCGXFRHKYIHAKGNNALVEFGSSSYSRMKGNHTFLSYKSQQIVVCFFPTFSGSRSSVLAVTAIGIVFSILLLIGALGCGMYALQRVTAKRERRSRRRRRSQLQQVDVNLPHLPKLPNYFDTDYNSVLPQYLGFRGEVNKAVSESPPPYDEPPPYSITEAAETVGVETTVQKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEA5</accession>
    <name>A0A6P8HEA5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290463</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553353.1">
        <property type="nucleotide sequence ID" value="XM_031697493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEA5"/>
    <dbReference type="GeneID" id="116290463"/>
    <dbReference type="KEGG" id="aten:116290463"/>
    <dbReference type="InParanoid" id="A0A6P8HEA5"/>
    <dbReference type="OrthoDB" id="5960270at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553353.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45411" checksum="6F9B5D3ED1B5B7BA" modified="2020-12-02" version="1">MASWRITIYASVAIIVFILFLILNFAYLPRRKLSLEKNLSTHKSWSSEGTTNVPLTRTSAGLKEEERELTLEDFKARQWNCSNTTVTTTHTSSNKSQSVCYNEHTDPFMCFTDPVHCKQKLTKDDPRQIQWPKYGEYEYLPKSKWKYIIVNGGVVFLYHPCAKPELVKKLKRLARSCLHRHVITPYENLDPAQDFAIVAWGCYYSAKELNSTAGRQWIQNNAMKGPATHVTNSGSFNEGLKHDAPIVSDIHESELCPSELSRYVSNHKNDADGNPKDTSQHPQWEGRLSIKATERFVIVRGEDGRLQERRKFDSANAAWALGSLVFLCGLIVAFMLYAKPCQQKDYWWRTDEITYNSNSKFSILKNRRLFWKGNNRQSAASAKLLGVIPEESDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEK3</accession>
    <name>A0A6P8HEK3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551005.1">
        <property type="nucleotide sequence ID" value="XM_031695145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEK3"/>
    <dbReference type="FunCoup" id="A0A6P8HEK3">
        <property type="interactions" value="3533"/>
    </dbReference>
    <dbReference type="GeneID" id="116288369"/>
    <dbReference type="KEGG" id="aten:116288369"/>
    <dbReference type="InParanoid" id="A0A6P8HEK3"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551005.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="59408" checksum="389C91891C6313CF" modified="2020-12-02" version="1">MELEAMEARRAGVGHPAAAASGTSPPNPDPFHRKSVRKQPKAPQKKQGSSRFRAKVNVEIQQLSLLKDSPPAEQQELFVKKLQQCAIGFDFMDPVAELKGKEIKRATLNELVDFITSGRGILTEAIYPEVVKMVASNIFRTLPPSDNPDFDPEEDDPTLEASWPHLQLVYEFFLRFLESPEFQPSIAKKFIDQKFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAYIRKQINNIFLKFIFETEHFNGVGELLEILGSIINGFALPLKAEHKMFLQKVLIPLHKVKCLGLYHAQLAYCIVQFLEKDATLTEQVVLGLLKFWPKTSSQKEVMFLGEIEEILDVIDPQQFQKIEEPLFKQISRCVSSPHFQVAERALYFWNNEYIMSLIEENSNTILPIMFSSLYRISKDHWNQTIVALVYNVLKTFMEMNGKLFDELTSSYKADRQKEKKKEKEREELWKQLDKLELERRKKLGLPPSGSLKPNNSSAGNPSSTPSDKNKSTPTPASSGGTKNIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF92</accession>
    <name>A0A6P8HF92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116291985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555079.1">
        <property type="nucleotide sequence ID" value="XM_031699219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291985"/>
    <dbReference type="KEGG" id="aten:116291985"/>
    <dbReference type="InParanoid" id="A0A6P8HF92"/>
    <dbReference type="OrthoDB" id="10068085at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031555079.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31499" checksum="9D37347F967488A0" modified="2020-12-02" version="1">MVNFCAVYGCSNRSNREKNRSFFRIPAIIYHSDEKTKNLSRERRQRWLAMIQRQDLTDSQIVSTRICSDHFISGKPSALYDTLNIDWLPTLNIGTNIDRRYRKGTYSRIKQXGEKRKRADTADTLLHLSQPAAVPILDLPIVTLKEEDDDRPFKSCAAMTCVTMSDIERLERENFNLREENRDLTAKLRTLMRLAMVTNRDKILGPPLSDTQPVEVLQQVPHTQPVAVLHQMPHTQPVSVSPMSRTQPAVPEVTSMAIGEVALVKVLNINHSNIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGV0</accession>
    <name>A0A6P8HGV0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551822.1">
        <property type="nucleotide sequence ID" value="XM_031695962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289072"/>
    <dbReference type="KEGG" id="aten:116289072"/>
    <dbReference type="InParanoid" id="A0A6P8HGV0"/>
    <dbReference type="OrthoDB" id="5990505at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028415500" evidence="1">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="2">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="2">
        <location>
            <begin position="160"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551822.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30861" checksum="DAB4E023B5C982F7" modified="2020-12-02" version="1">MLTGFTGTVFVLILVNPSIVDGKVMLTNSPSRIEAFAGETVRFNWNYTVDDKNMDFGYYVSSPVWYYYNPDGHTKSVIAVDDGLRGWKWTISRRTCPPRLLYPTVRVSKESVATLVISNVTNNDSGGYGISLVLRISPSINNKVELIVTDKMARFTKVPSSTLFVSXGKTARFEWKFTYDNRNIRLLSESPVWSYVDQNNQWVTIATGGKXPSSSAVIKTTTCPARLLNPTRVRIEQPATLIISNVTEADNGIYGCMLKLRRXLSINSTSTLVVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH45</accession>
    <name>A0A6P8HH45_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116292073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116292073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555171.1">
        <property type="nucleotide sequence ID" value="XM_031699311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292073"/>
    <dbReference type="KEGG" id="aten:116292073"/>
    <dbReference type="InParanoid" id="A0A6P8HH45"/>
    <dbReference type="OrthoDB" id="5984779at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031555171.1"/>
        </source>
    </evidence>
    <sequence length="1094" mass="127423" checksum="43A406620D18344D" modified="2020-12-02" version="1">MAFHCDACDKSFTEETNLVRHKKAIHSGRLFTCERCGKQFNRKDALKRHEQVCEGRSSKRKVEEKENTPPVKKQKTMSDAELIEYELANIPPEMYEEYDGEILGDNEVDDVQIGGGETEECALGGNVTTFKYKPNKHEKYDLLLTLRGKKNTIIKKLKTQLKKHRGIKWFLCVKVKMVKSSPGGEDQISTPHFRTKCYTAVNDTEIEKNYVHGMEKIKNSFLEYQREGSGWLLEEVLEIDLGIAAYTPLKGSSYIPLPXKIKDKKAVLNIQNEDEKCFLWSVLAAKHPVHWQNNANRVSNYQRYEAELNMSGIEYPVQIKHISKFEKQNREISINVLGYEDEELFPLYITKENKELHVNLLLFSQDDTRHYCLIRDLDRLLYSMNRHEHHMYHCMYCLHGFVRRDLLEDYEPHCSKHGPQKIRLPDEDHTTLSYNDVQKQLKVPFIIYADFESILVNCDDTELDPSTSFTQKTQQHIPSGFCYTVVSTVEQYCFPPVLYRGEDCVDKFLDCLIEERKQIGEILKMVVPMDISEEQEREFQAATLCHICNEELGADRVRDHDHLTGAYRGAAHNDCNLNYKFTGKIPVVLHNLRGYDSHLILQKLGKIKGENISCIPNNTEKYISFSVGDLVFIDSLQFLNSSLEKLVMNLSKEGDDKFKTLKKYVESEKVSLLLRKGVYPYEYMNSFGKFEETGLPRIDCFYSSLTGSTISQADYEHAQNVFREFQCRNLGDYHDLYLKSDVLLLADVFENFREVCLEYYQLDPGHFYTSPGLSWLACLKMTGVELELLTDPDMYLFLEEGLRGGISMITHRFARANNRYVEGYNPELENNYIMYLDANNLYGXAMSEALPVNNFGWLSDPEVDELRENLMTIPVDGGEGYILEVDLSYPKELHDFHNDYPLAPERRKVTEEMLSPYCQQLLEDLNLGGAPTDKLVPNLNDKTKYVLHYRNLQQYLSLGMKLEKVXRXLGFDQSPWLKKYIDFNTEKRKNARNDFEKDFFKLMNNSVFGKTMENLRKRVNVKLVNTEKQLKKLTASPLFDYFRIFDENLVAVNMKKPSLYLNRPIYIGFSILELSKTLMYDFRYNYIKQKYSXQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH69</accession>
    <name>A0A6P8HH69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bcl-2-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116289198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551937.1">
        <property type="nucleotide sequence ID" value="XM_031696077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289198"/>
    <dbReference type="KEGG" id="aten:116289198"/>
    <dbReference type="InParanoid" id="A0A6P8HH69"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF47">
        <property type="entry name" value="BCL-2-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="8">
        <location>
            <begin position="52"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551937.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21499" checksum="0BD3F40C754EB243" modified="2020-12-02" version="1">MSXISSYDKVGNPSARKMKTTEEKIAHELAKDFINFKLGKGTRLNTKTATLLRKLSKEIEKKHEPIFKNMCDRLNLNERTVSQTFVEVADEMLGKDINWGRIVALYTFAGRVAVYFEEHDVKISDEIAIWLGNYVAGKSEWIRKAGGWDAFNEQFKDVQEENEKFWWNSLLCTTLGLGTLAAVLYVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHE0</accession>
    <name>A0A6P8HHE0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555819.1">
        <property type="nucleotide sequence ID" value="XM_031699959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHE0"/>
    <dbReference type="GeneID" id="116292613"/>
    <dbReference type="KEGG" id="aten:116292613"/>
    <dbReference type="InParanoid" id="A0A6P8HHE0"/>
    <dbReference type="OrthoDB" id="5976429at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="145"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555819.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37453" checksum="EB4006BC223E118D" modified="2020-12-02" version="1">MGGKYQRLTSEAGSKTLKTGLFSYIFFTWLNGLLKLGYQRPLAYDDLLELSDENKAQDLVAKLHGLWMEEINSAKKRGRKPRLWKAMFKLFLRDVILFTALKLVDEAMGITLVVSVWFYLKFLEEGSHMDQTYVVGIVASIGIPSLIKVFFYHHSDYLAVLMGVRLKSAVIGLIHKTITESRRSDLSKFTTGHIVNLVSNDAKRMDELGISLGEALSTPIAVVVVVLLPLLVGWPSLSCLLLMLVLIIINLLLTQLYTNIRLEQAKVTDKRLAVMSEIICGIRAVKMYAWEWKYNETVQALRGYFQILFSYYYFICVYNFDRESCLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHG1</accession>
    <name>A0A6P8HHG1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 69-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555839.1">
        <property type="nucleotide sequence ID" value="XM_031699979.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HHG1">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="GeneID" id="116292629"/>
    <dbReference type="KEGG" id="aten:116292629"/>
    <dbReference type="InParanoid" id="A0A6P8HHG1"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555839.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25288" checksum="429CA92F57DC2D63" modified="2020-12-02" version="1">MATIMRYGIYGRSLPSFKKISLPLYSTSHLSSYWPRKGYKDRFLMNISSFKKSQLISSQQRATYIXVLSRSYCSENSKDSMFEDLKSSPTSAIWLGFSGAIPFCSLAGLSFITPEYLDTIMHAQCAYGACILTFLGAVHWGYAMTKDSPLKPNWGTLGYSVTPSLVAWSALLIKPQYGLVTIAIGLLYALSKDLGTPFFPRWYHALRKVLTTLAASSMLLTATAFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJK3</accession>
    <name>A0A6P8HJK3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555048.1">
        <property type="nucleotide sequence ID" value="XM_031699188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJK3"/>
    <dbReference type="FunCoup" id="A0A6P8HJK3">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="GeneID" id="116291957"/>
    <dbReference type="KEGG" id="aten:116291957"/>
    <dbReference type="InParanoid" id="A0A6P8HJK3"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031555048.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12152" checksum="D8C1F0875D4131E0" modified="2020-12-02" version="1">MTSLILAGLGVAGTAFAARFAVQAFKRIDMNAIPKVIPKLPTFSHYYRGGFESKMTKREAALILGVSPSANKVKVREAHRRIMLINHPDRGGSPYLAAKINEAKDLIEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK22</accession>
    <name>A0A6P8HK22_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione hydrolase 1 proenzyme-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556156.1">
        <property type="nucleotide sequence ID" value="XM_031700296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK22"/>
    <dbReference type="GeneID" id="116292947"/>
    <dbReference type="KEGG" id="aten:116292947"/>
    <dbReference type="InParanoid" id="A0A6P8HK22"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000009">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="445"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556156.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="68359" checksum="D4F9551328778431" modified="2020-12-02" version="1">MGKNTKGNGRFFLKLITAVIVLCAVCTLGFLTGMDKKISNFFLKDSSLHESKRSSNVPTIPPPDPLEFEHAAVAADHKLCSKVGRDILKKGGHAVDAAIATALCVGVINPHSAGLGGGGFMIIYDRKSKRSSAIDFREMAPGRLTSKGTEEMLHVLHLMKLREQSTMKPSEGLLVGVPGELRGFEKAWKRFGKLKWKDLFQPAADICKKGYKVHPSLATAIAKNALNITTSEGLSEIFTHNGRVLAEGDVIKRPVYGKTLEMIGKSGGADILYNGKFSKDIVNEINSEGGIFTLDDLKKYEAIEREPLKADIGHMDGAKLLSVPPPAGGGAVMSQALQILSGFNFTKKDMEENPGLTYHRIIEAFKFAHASLTFLGDPKFVGDTTKTVQKMLDSKQSKRLRDMIDGKTHPVRYYGPINYQLDVTSGTTHLSIVDEEGNGVSLTSSINKYFGSKIRSKKYGIIFNDQLADAMNHWVNEFGLVPDSFKAHRKPLSLSCPAILLDKNDDLQMVIGAAGGRYIPTTLAQVFMNYYWFGDSLKDAVAKPRLHSQLFPEMVLVEENFPNKLVNDIRKYGHRYVTNDTALFTGTPGQIMGVVQVIARKKNGELLALADYRKGGIAAGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK68</accession>
    <name>A0A6P8HK68_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031553087.1">
        <property type="nucleotide sequence ID" value="XM_031697227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK68"/>
    <dbReference type="GeneID" id="116290222"/>
    <dbReference type="KEGG" id="aten:116290222"/>
    <dbReference type="InParanoid" id="A0A6P8HK68"/>
    <dbReference type="OrthoDB" id="10314692at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="7">
        <location>
            <begin position="332"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553087.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="63381" checksum="4B87056C9499C84D" modified="2020-12-02" version="1">MVNKGPLFTVSLVPNRHDRTKKVIQIDRARPSIPIEEYQKPRSKKLSELRHLIIFTVTVVLGADTNTTIAKVDEMLRFEGQLANVSLLDDLFQPGPVFNTSLLYFQHMVPQFDWIGYFNELFKPLWIPKSEILYPKTLVYLRRALRIIQNTPKSVLANYMVWYVLRSEVKWLSVKYYEAMKGIKVPKQIRFHSCVYSSETSFGDLLMVAYINDNHTQLVRSKNMAKIMANEEIQAFGENVKELTWLDNAAKSEAIQKINAMAIHVAFPDYMLNSTKLAILFEKYRGLNITAETYYKNKVSIKKRLRQHEIKDFRKPIDSALWKFPPPQALTWYFVDSNSLYVSEEYVRPPLFYHNEFLRAYNFGIFGSTAGHLATKALSADGKYFDKDRKRRNWWSQQSHQEFDERLRCYVKQYSAYKTLGKWPINGEKTVNENIADNDGLKLTIKAYYNWAKRNPNEMWLLPGLNFTNEQLVYIGFAQGHCGYTPPQDQYHRKDSRHGDRKFRVIGTLANSIEFANAFNCKINSTMNPIKKCHLYSKDGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKC8</accession>
    <name>A0A6P8HKC8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116292220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555348.1">
        <property type="nucleotide sequence ID" value="XM_031699488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKC8"/>
    <dbReference type="GeneID" id="116292220"/>
    <dbReference type="KEGG" id="aten:116292220"/>
    <dbReference type="InParanoid" id="A0A6P8HKC8"/>
    <dbReference type="OrthoDB" id="5951217at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555348.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="67510" checksum="50886E076E3967F5" modified="2020-12-02" version="1">MEIQDRTKCFLFDNLRVETIRQLQAYIKDGKGTLAELKDRYRTSLHELTENEREEINTVEKFVEALKEQGAIRANDVMLLRLLAEEIGLEELKQKVEEYEADCAGIFRRTLNGTMIHLKTLVSSRGVQITIAGAILMRIYGNNPERLLNLQPFVEFAAELIDVVRGSIVFVLKVSSISSVKRLWQSYKDGSLKEKLKKSLNEMEELKELSKGEEIDVEVTIDEEEYHEALYNLILFDVKGKSMKDDKSQRRHSVCCERDVPVKVDQVLSQGQQGQKRSSADVQPEEDVKTKKPRTTINNRERDHAEDSEMLKEAIKANTENQTKIMAAHDIPSAKTDDIFTNLTVREQVEKNENLISFCHIPLLSFLLCWCLEWRISRSGITENLPAKITDLYDDVVKVLIEKLHANLKYSEMSEYAKKIAEETINKLAKLAANLQKESKYIFDEEDMKKLDLSEDEIKNLKVSGILHCVPGIRITAFETKAEFSFTHLTLQEYLSASFFVKYKEIPEDVSNQTFVFMCGLLSKKKDGEQLMNKLIQQISPKDNRFKLNKLRMLQCLYEYGEQELTTITMSCTINTVIVMGSLVLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL67</accession>
    <name>A0A6P8HL67_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116290468</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116290468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553360.1">
        <property type="nucleotide sequence ID" value="XM_031697500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HL67"/>
    <dbReference type="GeneID" id="116290468"/>
    <dbReference type="KEGG" id="aten:116290468"/>
    <dbReference type="InParanoid" id="A0A6P8HL67"/>
    <dbReference type="OrthoDB" id="5963755at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031553360.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15649" checksum="9307D5BEFD0BC3FF" modified="2020-12-02" version="1">MKVNSQVLPLSPFLRQKGQVYLEDPGCISSKIRDLKTDATEHLARFSNFSTNADSTRTFKTDYNRRARNVISSRKYRKKRKIQYMELERDNRLLQQAINEAEKVHHQVSQAFHKLIQHAECCDKCCNIKLCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLH3</accession>
    <name>A0A6P8HLH3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116290544</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553460.1">
        <property type="nucleotide sequence ID" value="XM_031697600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLH3"/>
    <dbReference type="GeneID" id="116290544"/>
    <dbReference type="KEGG" id="aten:116290544"/>
    <dbReference type="InParanoid" id="A0A6P8HLH3"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="136"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="472"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="556"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553460.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="70341" checksum="36D21E56B6E06D33" modified="2020-12-02" version="1">MEGNQIIKLNVGGIIYHTTKNTLLFEHDSLLAKLSRGESQLGLMFTGSLEKTNSGKEVNEDVEIFIDRDGTNFKYLLNYLRSGHLVLPEEENVLREILLEAKYYNIKGVIDELSKPCYKIKGVVPISDELGAFWESLILDNEKKRFLESWCGGEGKKFKLLYRATRDGWSADIFHFLCDNKAPTVVVTRKGSSVFGGYTEKSWSGTGNKTDKNAFLFSLSNPSGLGPIKIQLNEGEEEDAVYCHPSQGPVFGKGRDLVISDQANVSHCSSRLDNTYKCPANQISTLFLAGTLTFTLAELEVYEILSIAYWLDQDYMRRGEYNTCCYWLDLTVYYFSRCIDHTKAKSIVWISEFEFGRLVSKKRFKNMEKLREKRQAMQEQLEEIEKREMLAKKKLNWLEEISGKNKTEAETLRRSCSLTEYNLDKTEDLLDQKIASLKSALVKRDKEDQIIKVLEQRDLEIDEEISRFEPKVKQAIHRADEAEMKYHEAVRKLSLAESERNKVIGRRNAKENQVQALQTSLKNAGRQIHRLAISEEKSGDREDEYFRRCRHLTECVSHCLMRAEEAERRIKMLQNRKDNLEGEKKTYEKNLAMMRRELDETLNNLDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLL1</accession>
    <name>A0A6P8HLL1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116293358</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556636.1">
        <property type="nucleotide sequence ID" value="XM_031700776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLL1"/>
    <dbReference type="GeneID" id="116293358"/>
    <dbReference type="KEGG" id="aten:116293358"/>
    <dbReference type="InParanoid" id="A0A6P8HLL1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556636.1"/>
        </source>
    </evidence>
    <sequence length="901" mass="98733" checksum="311112AF793E3AF8" modified="2020-12-02" version="1">MPYNKGADVNVTDNDGKTALFYAVRQKNNKRVVQALTDARVNVNITDKDGKTALFYALEQKNSESVVQVLIEGGADVNITDKDGNNVLLHALGKDYFESLILSLIDAGADVNVLNKSQQSALYFAVQQCDNESVVRALIEAGADVNQTVVNSSTAMFVAVSLSSNEGVVRALINAGADVNITNNAGQTALFNAVLERNNESMIHTLIDAGAKVNVVDKHGGTAFSYALTRGNTDNESTVLALIARGAKVNISKDGKSALLWAIEQKCSESVVRAMIEAGADVNKTDCNNKTPLYDAVQYDRNEGVISVLIEAGADVNLIYDGGKTILFYAVEKYNNEGVVRSLIDAGADVNISSSDGKTILFYAVQHYYNKNVVQMLIDAGADIKVTDMNDQTILIHVVQVRYDIDEEKDEKARVLIDLGAEVNNRDKSGKTALLYAAQSNNVNLVRVLINAGADVHATDSDGQTALLYAVQQNDNENVVRALIDAQADVNTTDKYGYTALFHAVQQRNNAENVVKALIAADVNVNAIINDGQTALLYAVQQQNNEGVVRALIKAGADVSITDKYGKTALFYAVQMTWRGEGVVRALIEANEDILTVKDIYGRTALFYINLGSSKAAIEYLLEKGGIKCLRLKDNCNVDILTFAIENYISETGMYDSFKGGILDKLTKQGIIKRESVARAMINIMFRKYVAEVLNSSNIEISSYNLRNFEGLSCLYKENVDYNVWERTKKMESFLAVLREDFRGTSKALELLVELGADPDSADSDGNTALHLTARSPLMGASKETVMDLCKQLKKFEVRFNARNHENQTPLLFCLSQITGNDSQSPIKTVVKVCRFLVKNGSNIEETSRTGEAVFHFMMKLFQGSLKLYDTTARQEVLNYVIELLQLFVHTESAKVAVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLV7</accession>
    <name>A0A6P8HLV7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trichohyalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116293435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556721.1">
        <property type="nucleotide sequence ID" value="XM_031700861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293435"/>
    <dbReference type="KEGG" id="aten:116293435"/>
    <dbReference type="InParanoid" id="A0A6P8HLV7"/>
    <dbReference type="OrthoDB" id="5986944at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005539">
        <property type="entry name" value="ELK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01188">
        <property type="entry name" value="ELK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="1374"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="1992"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2126"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2171"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2258"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2454"/>
            <end position="2475"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2502"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2718"/>
            <end position="2739"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2760"/>
            <end position="2781"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2787"/>
            <end position="2807"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2832"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="2884"/>
            <end position="2905"/>
        </location>
    </feature>
    <feature type="domain" description="ELK" evidence="4">
        <location>
            <begin position="3020"/>
            <end position="3040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="726"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1150"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1565"/>
            <end position="1591"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1622"/>
            <end position="1649"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2821"/>
            <end position="2842"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2994"/>
            <end position="3033"/>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="150"/>
            <end position="325"/>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="355"/>
            <end position="467"/>
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    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1472"/>
            <end position="1538"/>
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        <location>
            <begin position="2050"/>
            <end position="2088"/>
        </location>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2147"/>
            <end position="2266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2290"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2475"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3130"/>
            <end position="3257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031556721.1"/>
        </source>
    </evidence>
    <sequence length="3318" mass="390966" checksum="7F16E408F888ED47" modified="2020-12-02" version="1">MDDDESERQKKLQAGKEKLLMFQKKKQGVKKKKRKDKVCGNSSGSASGTSGSEGAKPASNQEQLEANSKQQPVQSASQEASPQKKERELEDISQTDTDHDAPSIHSEIGSPIHFEDEGGFHSGQSGSYASGEYTSGEESYTSEDGGVDSLVFANIERNELKNRTTELEEELTAKKSALKQISRENADLKSKLDLMMKDETGASVIKDLTRQVEEYRENLRTKQAILTDINKENQELRAQLSGKKPIQGDAVKVEQLTKVLEVKQAALEDLNKLNEHLDAENKQLKNQISGLSKGSDSSLELQRGLESKSAELEELKNFNELILEENTMLKEKLSSNELEVDDDLRQKLRVKDQALVEIQINYQSLLHKLEEVESQKSRAQIQESFQQLDDLSALVSQKEAEIANLIAAREQLEEKLENSAHIHVQLEESHRRSVDLEMELDKLRAQIRDLEREASKTSDLYEELRIKEETSNRLYHENEDLKARLATIESSNLKELLEEGYRNLEAMSAELKEKNTEVERLSNTQQLSNKRVNDLENEVVSLRALVASLEDNSLSENSQMENLRENLKAKQQTVNQLNQESEELREKLSQLKELSKNDKELLNTAQDKVVELEGELNKKDEELEKTRSSQKIMEDDYQKKISELLQEIVEQRRQIDAMEDNSKSESSVLENMKTSLKAKQDTMMQLNKENEEVRAELEKLSSKLDEVSQDRDNKNKEMEEVKSERDNKLLQVMEQLAGKDGELDDLKTANEEREKKLQESQNELLTFKTQSENLAEQLETAQNRLLEFQSVVETKENDIRKLNEQLLNIRTEQEGLKQDTIQEGQEMLGKIKMLQQQLAESDSTLKKQQENMQKTSDEVVDMTSVIDDLKHQITKKEQRIEELDQQLVESREKSALELKQAAEEFNQEKSRLMKELQEKDGMLENLNGEFSVLKEDLAKKESELEKMKGEFIATISEVETMRVQFEDEKEKSLNLENQLEEIRRKNDEELERIQSSYQEEMQKETNEHMKELQGLKTQLERQIEEKGLERDLSMKTEVDQLRAIYDSEFNTLKDSLEKQKSLSSELEKQRDEAQVNYDQVRERFLEKEKSLTELQEVLKKNSQENERVIEELRDEVSKYQEFVAKRESDKEMTESHKEEEKLQREHSSKEIDRLAMELEEEKKKSLHVETLENDVSTLVEEIKDLKNELMKKDKVIAELNDNLTSFEEEHDSEVSLHEDSLRKEQEKAAELEKKFVLEISSESAKHQQELELVKQTYQEAMNELKGRLEEAEAANEAMQENQAREMDDFKSKLEEYTKNVEEQLFQLKAETENKAKGDIKKVQESHQKETQKLMEKLKNLTTEKEMKDAENETLKKQLKDMVDQQNSGIDNEELLKRRLEIMKEEYEGQINSLKEQLQNLDEKHQAELGDFSEEKEQQFVTVMEEVIQKHQRELEELKAKSGSDGEKDFDERLRTMEEEKRLEINRVHERLLQESEERLAEGQQLLLQQINQKEQEVLMTKEKANELERELTGVRKEKDRLLXEVQILTETRKIMDNERSXIKEPIIGKKIRQVVQEEPLFAASIADQVEGLPPSADSEETPSSSERPELANKLQQMEEIIHEKNKVEVELNKQLNDLKKELKHARESSKKDLHDKQQRERTLESSKEQLEMQLSALERDSYDSINELSILQERLQEKERVVEELKDEKDNLLSVLKENNEVASREKESLLNACKKQDVMIKELQDRISTSDSVSNDLQDVFGRQILALQDQRDELQQQLEQQKQERSSYVDILEEKSVLEENLRVEREKLSEKLRQKEVLERELNRERAALQEQLFKQSKLNEIIRQKDSFEKELIRQKDELEDELGEIEKKLMEKEELLIREKELLEQEMKNKEMQLQEWEKEFHEKEMEFSSSLDQLRRELDTDYRQQMVQLESTLQDRYSQDMETLVAGHQEQIARMSDDFEERLKVLKSQLETERLKQVSTMKSVLERQQSSELVDLEEKHRGDLEEIRDDLSQRHQEIIQAVKTRLDQEHKEVLEELEARMLADHAIKTELLRLEVENEWKVKLNEVEKQRFTVQEEMERQLQEARNEMKEIKEKHKLEISEKMAAQQKELENKHKADLTSELEKQDSVLKESHQKELEEFGEVLKQEYTRRIQDLDKEYSKKHSAEIEELQKALERDKEEFTIATLDELGQKHTLEMQRLREELNDIMNQAEQTKMQMEKKHQEEMLDMNNKITHEYEKIEKLRADLESAHDTTAQEQAHRLEELRDEMEQQKSQFKKQHLGELEELKGEFERRLVEKDHDHAEALETLRTEFENKKLESELEHVREIEKLTEEFENRHLSSEKSYNEKINELEKQLLNTKEDFETKLQEQLGQGVKDSQERYQDDVSKLTEELQVQNQKELEKLRQECDQEHQKKIEQLEDTIRTLRSEHEKQCEEIRGAFQEEKLKDYAKMSTKMALKTAQSLEVLRSSMEKKHEQEIEEFREESQKDYEMTALRLSSQIEEMEQRNRKTLHELKNQLKEKDKEIENLKLELSSKDEELSSLSNSFSEEVKNIQKNQYDDLLNEVSFVRAELAMEAAQKIEEARLKSNNNLQDVNRLEEEYKSNIQMLLTKHDKQVADLSQEYEKQIRELKDELQVAEAWGKKNGEKVHFEEVEKKLQDIKDHYEEEIQKLRNEKDVESEGRKVDIEEKHVSELMEKQAERIKELEHSLEDEKKKYHDAEEFLTSKHKEEVEALKSKHLQEMVELRESFSSDVEALKEELVKTSDDEKFVLLKDELEKKHNDELVALRDYMENRYQGELEDAKQKYRNELQKLQEEMLNAEDQEKFEKLKESLEKSHQEELESLKNELEEEHEEHIRNLRDEFVEILKAKESEEGGDSEAEKRIIEQNQQDKLDALRQELENEHEEQLQQLKEEFLQLLQEKEKSFLANQGNPDIEEELQKLREQLETEHEEDKEKIRMDLLSEVEEFKNQLQEAAEKDIEEAKAQLQEQMSRKEEEIISKSDEQIEALKQEHPQEMEQQDKDLSEKHKNELANLRTKHEQDLKELREKFDEELRTERSKLEQEKQHDLERLKAAMDGSISEQQQLQLSMLQEQHERELETVRAELVEAHMKKFAEMASRLEGEHKDDLEDSIQAVRVEMKQKFKAEIEQAKEKARLELEQEHLQNLQLLEEELEHKHAAQMKGLATLQDKHQEEIQLINQEHNKSMEHIKAALEEKYNEQFLAVSSAADQEVSQAKDELETAHRNEIQMYEAALEEEKARVLALEAVQASLQTTHKEIMDNAKEESDRRIESLQALMDAAHGNQVQELQNLIEEQHKQVRYDNHLIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLZ3</accession>
    <name>A0A6P8HLZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Furin-like protease 1, isoforms 1/1-X/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116290699</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553660.1">
        <property type="nucleotide sequence ID" value="XM_031697800.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116290699"/>
    <dbReference type="InParanoid" id="A0A6P8HLZ3"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000021">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF23">
        <property type="entry name" value="FURIN-LIKE PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027828523" evidence="14">
        <location>
            <begin position="20"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="15">
        <location>
            <begin position="421"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="616"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="946"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1072"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1213"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1372"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="951"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1161"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1228"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1245"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1269"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1372"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1395"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="17">
        <location>
            <position position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031553660.1"/>
        </source>
    </evidence>
    <sequence length="1458" mass="161705" checksum="5177F13E1799B564" modified="2020-12-02" version="1">MRAAIAQVVSLIFLSLAGANEESDQIHYTNSWAVHVDEDDLDSVNELANKYGFTNLGQIGSLPGYFHFVKDSIKGRNKRSFDDDHTELLLAEPTQNIGQSSGPPGLDINVLPAWGQGYSGKGIVVSILDDGVDHTHPDLKRNYDPDASFDFNDFDPDPKPRSKDPLNCHGTKCAGEVAAEANNGICGVGVSFXASIGGIRMLDGKATDTVEGSSLSYHSNYIDIYTCCWGPKDDGKRFGKPGFLASKALQIGAERGRGGRGNIFVWATGNGGLTDDDCNCDGYTTSIYTISIGAISDHGLSTYYTETCASTLAVTFSGASHREAEENNIVTTGLDHKCTKTFKGTSSAAPLASGVLALVLEANPNLTWRDVQHIIVETSQKTSPLDEGWKKNGAGKEYNHKFGFGKLDAMRMIKKAKSWENVPKQRVCYSKEHDTPRNIPSSGNLIVSSNTSSCVGTTSEIRKLEHVQVKISLEHRHRGHLSVTLISPSETRSELLKTRRNDHSTQGLTDWVFMTVHFWGEDPRGTWTLIVTDNDRNTREHHVIKAKQGDFEDVTRVVMDDAEKQGPWDSNKIKEYDNIKQAPPGNYSSQDHILKGMENTMGELVKGNKFTELARRKKDRHHGAKGFVGNKSGHAQYKHKSSKHGTKKKNKHWTKKKTLKXYKTETNKHKDLENKENAKKTGRKMNSKKIHKYYKHKGHKKYRYTPNKQRKHRKDKGQVQGEGKSLMAEGSVEIPKGRTPLEAKIAIQAIMEPYFKVSASRIVLPKRYQGFMGEVDIKMKLAKETNKERLAKDENKKSNHTIQLGSAREISFHKFRGQQISVSKMLQVPEVXTQNNEVKKLTHDLGMEPFRIPSXEVKVLEAARQNTELQNAPVGIPGEVQGGQNKAKNDDNIYINLLNSIKSMPHKGKAIDNSLEHFDERIDILTDAKPYSNDNSTSMLKNLTLDDRRNSNTGSEFTRSNATGSAFNGSNDTGSNDTGSQSFGINLIRDGLSRGNSSERNTTGNHLDDFKGETIYDTLSNVGIGNEAFRXEEIPIIFYDAVKNXFAEVRKLNASDLKTQAPKATGNEIIGTGNKIAGNGSQGKAVESGGEEVPDESSGFSGSSGVVIQEGTDCDDGNSFAIKCQITGQANDGMMSQSTEELNNAFEDVKADDDTGGIPQPQGTHDFQISSNSPTAKMQPLNDEDKLAYLLSTGKYPGSPEGTSKQVIAQVTKLRPFNTSDPKDQSVPDRSNMSMGSIQDKKSKSLQTSIKQQNVPVTLSLKEGLSQPEQKRPLNENVPDRPVEQDIGPTPSNQGIKIDISDLEPLDQFANKDFKALESALEKQVARLEKFRDDSPTGTRFLQRVKDDIRQRNVDDLKFIEDEIRKDMREAVDERXSERKAYSDGDSFIEGSREDSDDYDENQDXDGDGFHRLERRRLSKHAPKHELFHHYKHSRDDNKYGKGNSGILKSWTLILYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMB8</accession>
    <name>A0A6P8HMB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ homolog subfamily C member 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116293549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556851.1">
        <property type="nucleotide sequence ID" value="XM_031700991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMB8"/>
    <dbReference type="FunCoup" id="A0A6P8HMB8">
        <property type="interactions" value="2841"/>
    </dbReference>
    <dbReference type="GeneID" id="116293549"/>
    <dbReference type="KEGG" id="aten:116293549"/>
    <dbReference type="InParanoid" id="A0A6P8HMB8"/>
    <dbReference type="OrthoDB" id="18010at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031556851.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="62348" checksum="4C7E83752CC642F5" modified="2020-12-02" version="1">MADQDEGQEDDIDYYGVLNVRKQATDEELRSAYRRMCVLYHPDKHLDPAKKTAAVQLFSKIQKAYDVLNDSETRAIYDVYGQKGLDAGWEVVERKRTPAEIQAEYEQLQREQEERRLQQRTNPKGNISVGVDATDLFDNFDVFEDRTLPNIEISNMTIMQSIEAPLTRRDTATLSGNLGVGNGIGTGNISASIRRVLSSKAWGEFEVGAGTGPNIALRGFRNLTRRSYGTSGINVQLKGDVLQVGFEAMIARQLSKNVNGYLTWRAGIHSCMNTTVVRETEHSRALLVLQLGIPNTFAVASYTRKLENTRIKGAFKTGVFGSILEYGVETKISQHSHLGATISVGIPVGVTLKIKLTRATQVYNFPISLSEELSPAAIFYGTFIPLTAYWVVKILIVNPFLKQEKERENEINKEKIERQMAEKRREAEASIDLMKETYERTVEYERSRHGLIIISALYGNLVSMDNTDHYSHGRSKPCVIDVTIPVQCQVKDSRLFLTDVNKYNLSGFYDPCPDEEKLLRIRYEFRDVVHEVTVADSEPVKLPKQSHKVDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMR6</accession>
    <name>A0A6P8HMR6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead box protein D5-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553940.1">
        <property type="nucleotide sequence ID" value="XM_031698080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMR6"/>
    <dbReference type="GeneID" id="116290953"/>
    <dbReference type="KEGG" id="aten:116290953"/>
    <dbReference type="InParanoid" id="A0A6P8HMR6"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000598">
        <property type="entry name" value="forkhead box protein I1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553940.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33841" checksum="CEC691D780A966A4" modified="2020-12-02" version="1">MTEKESKLSTKLEDIALFKNEAKRKKEKLPKSLGSVPARKRKNGKPPYSYIALIAMSILDTPDKRQTLSGIIDFIKKNFEYYGGECPVKGWQNSIRHNLSLNDCFVKTWRDPTNPSKGHLWTLHAKSMDMFEGGSFMRRKKRFKENVETDSHFEEVYSTYQDTCFDEPREDLEKNLSRSDVTISSFRSADVDDHSSRVMSPDSLASPTDPHPRSRSCSSTSSRDKIPEQVFIYPPSPYNLLTAASPRLFPHYSSLAVRRTAYYRDLVPYGHGFEASSFPLTAQTGCIRCLGCTCAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN51</accession>
    <name>A0A6P8HN51_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556413.1">
        <property type="nucleotide sequence ID" value="XM_031700553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293159"/>
    <dbReference type="KEGG" id="aten:116293159"/>
    <dbReference type="InParanoid" id="A0A6P8HN51"/>
    <dbReference type="OrthoDB" id="5968907at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556413.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46714" checksum="062638B387B55973" modified="2020-12-02" version="1">MVYDEITLVAAQDVLAGSNIATTTVVLSIALSVLSMKLTVPWVMQAIPYGVKIIIIVFLFVTGLLFLVCSSKIPLRLVGVSIIEAGVSTSEITLMSLTAFYDSITVSAFVAGIGMSSLLGPFYYTALTTWLDWSPRNTIISTVPWPLLFLILYALLNKEPXERDLRREEFSIAEEEDTTTDKQDKTEITDTVKNNLTAPGLYEDSHKQNYEQISTWDKLKVAVKIIPFIFFLLVTYFAEYLSNHAVVTTLAFPXSSLSPRDHYTYYMLAYHFGKFIGRSHIFIISCFTPGLLGHVLVRKTWIIAAIAVGHFVLFFLMSWYRFVPHFEVVVTLCITEGFTAGSMYVNSVHAVSKTIEEIKHKEFALGLLTVGDATGKLLAGVAGLWQEPFLRRHCLEELDLGVYCFTRHVDESGWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNZ8</accession>
    <name>A0A6P8HNZ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAS/WASL-interacting protein family member 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556768.1">
        <property type="nucleotide sequence ID" value="XM_031700908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNZ8"/>
    <dbReference type="GeneID" id="116293477"/>
    <dbReference type="KEGG" id="aten:116293477"/>
    <dbReference type="InParanoid" id="A0A6P8HNZ8"/>
    <dbReference type="OrthoDB" id="10576615at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028163462" evidence="2">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556768.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="28984" checksum="03FA82671537460E" modified="2020-12-02" version="1">MSLKLTFCLLLAFLVCTQALPIKEKESGESGFYDSDDENTKEVETGEVDNYDDEGKDDEVDDEKESSFQTDDDAENPDKQGVTDSNDESDDESGSKKSSVSGEQEDEAASGSGSGSGSGEKPPKAEQAGPCPPPCSGPFTERWVPRPRYVPGPPVPPPPFQPPPPPMQAPPMAPPMCAPSCPMSCAPSCEPSCCGAAPVVFQPPPPPPPMPMPMPMSTQCQPSCAPTCCPPPPPPPPPPPPPPPPPPPPPPPPPPAICPQTCQPTTCQPNCPPICCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPD6</accession>
    <name>A0A6P8HPD6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294742</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558254.1">
        <property type="nucleotide sequence ID" value="XM_031702394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPD6"/>
    <dbReference type="GeneID" id="116294742"/>
    <dbReference type="KEGG" id="aten:116294742"/>
    <dbReference type="InParanoid" id="A0A6P8HPD6"/>
    <dbReference type="OrthoDB" id="5950208at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031558254.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31429" checksum="CF9B7E99DFABCFAE" modified="2020-12-02" version="1">MGDRSKLKTGNLGVNAMEEKRLNKYLNTLEKQTRDKVINTERQQKVMAKHFHKRLDKSAALARKQENIALSFKMPVNRCYSSKSKVDKGIHLINSQPEEPKLSESRNSPSLLLREWNQSFDVPYLKEYSFSWYPDTKPSSVMEMRCKMWQKISEFCLNGRERARSAPPWLRDLRAPAQVQRAHLKTLEVMRIQKSLVQSPSRQPVIDLQSVRTWREKEKKIACCAVKEFVKTIVPYKLRPGPSQQVHDINSFYRLLSTSEPPLKSFCCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQA2</accession>
    <name>A0A6P8HQA2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031558549.1">
        <property type="nucleotide sequence ID" value="XM_031702689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQA2"/>
    <dbReference type="GeneID" id="116294984"/>
    <dbReference type="KEGG" id="aten:116294984"/>
    <dbReference type="InParanoid" id="A0A6P8HQA2"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031558549.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="52168" checksum="857C7697D9A59E02" modified="2020-12-02" version="1">MAAANGDFDNDFPRLKQPLSENDPELYEILKKEKLRQINGLELIASENFTSQAVMEALGSCMTNKYSEGQVGQRYYGGNVYVDEMEALCKKRALEVYRLDPEKWGVNVQPYSGSPANFAVYTGLLNPHDRVMGLDLPDGGHLTHGFMTDKKRISATSIYFESMPYKTDPKTGYIDYDKLAENAQLFRPKMIIAGISAYPRHLDYAKFREVCDSVGAVLLADMAHISGLVAAGVVPSPFDYADVVSTTTHKSLRGPRAGMIFYRKGIKGYKKNGDPIKYDLGPKIDFALFPGLQGGPHNHQIAALSVALKQANCPEFKAYAQQTLYNSKAMAKVLMDRGYSLVTDGTDNHLILLDLRPKKLGGAQGEKILEEISVTVNKNTCPGDKSALHPGGLRIGAPALTSRKLNVSDFERVADFIDQGLKLGLEIQETSGTDFKKFLETLKTDLFKGKIEALRNAVEEFASKFPMPGNDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSL5</accession>
    <name>A0A6P8HSL5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294692</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558203.1">
        <property type="nucleotide sequence ID" value="XM_031702343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSL5"/>
    <dbReference type="GeneID" id="116294692"/>
    <dbReference type="KEGG" id="aten:116294692"/>
    <dbReference type="InParanoid" id="A0A6P8HSL5"/>
    <dbReference type="OrthoDB" id="5965072at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027925492" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558203.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18160" checksum="3B7479F456CADD42" modified="2020-12-02" version="1">MKRQAVLIVFFITIFQFTVAVKNKDKEALIKNNRNTREYKTLRELLGKPKDNPAAAKAIKGTKKTTRLHKICSWKKHMKNEPDEWAEDKKVYDKLICGMYTMKDEYKKHANTAAMILAGKHKDKSYEEQKKYLFDAVTRMAKAAGPLPPLNLKMIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUJ0</accession>
    <name>A0A6P8HUJ0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20 21" type="primary">LOC116293024</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19 20 21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="RefSeq" id="XP_031556266.1">
        <property type="nucleotide sequence ID" value="XM_031700406.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556267.1">
        <property type="nucleotide sequence ID" value="XM_031700407.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556268.1">
        <property type="nucleotide sequence ID" value="XM_031700408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUJ0"/>
    <dbReference type="GeneID" id="116293024"/>
    <dbReference type="KEGG" id="aten:116293024"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06370">
        <property type="entry name" value="PBP1_SAP_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14042">
        <property type="entry name" value="PK_GC-A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000420">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="574"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="911"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031556266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031556267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031556268.1"/>
        </source>
    </evidence>
    <sequence length="1168" mass="132716" checksum="C63A0FE19058587A" modified="2020-12-02" version="1">MERMDRLFLYLRIRRSIQRLFILGFSLLYYCSLSTGKEFKIGLIIPYKTVALHVGNNFMKGENFAAAITIAVEDLNSNPDILPGHNITFTWEDSKCEELLTIRQEFKMINSRVSAIIGPGCNCKVAARNAAAFHIPMISYMCSSTELSDKKLYPTFARTFAVDSQVTPSVISLLKKFKWTTVAIIYENLTKWIDLKDSMKRHLKANGIKVSYEGSTIGPFALHSKVMDDRIREMMSEIKNKARIVIFVTSFHMAREGIYIAFQENMISGEYVFIAFELDQVYAAKRKKLPFLWFQTDSHYRNRVNSSDFVSSVQKGSEAVLLLTVKAPLGSTYADFKKRLEDRTKDPPFNSSTYISNQGMTPPVFGAYLYDAVYQFGIALNKTLSRNETPVGEAIIEKMRDINYLSIQGYQVHIDANGDAEFNLTLLSSKYNPKTKEKEMTETGNFHIVTHTVTQRGTPDFRYKENMTIDWPGGRKTPPKDHPPCGFNGELCSVDEKKDNKTTIIAAVSGALAFLVLLFIANFYRHYRAERELQSRFWKIDYDELCFEHRRGSNTSLASTVMHQRDDDEEAGIPLLEDTTAEGKTTSIGKYKGNVVTVAKLPTRSIDLTRKVLLELKQMRDIRHDNLNQFIGACAEPPIVCIVMQYCSRGSLQDILENSDVKLDHMFIASLVSDIVKGMAYLHSSDIRSHGNLKSSNCLVDSRWVLKITDYGLPTFRSKVKKSVDNYAYYRDQLWVAPELLRNPNRDIRGTQKGDVYSFAIILHEFHTREGPYANSNLEPKEIIHRVKEREYPPFRPIVTKLIGGVEELRELMTQCWEEEPETRPDFPDIKKIMHRLLIQNGMKTNIFDNIVYMMEKYADNLEELVMERTGQLIEEKKKTDALLERMLPPSVAEQLKKGKAVEAESFNQVSIYFSDIVGFTSLSAESTPMQVVALLNDLYTLFDDIIREYDVYKVETIGDAYMVVSGLPIRNGSRHAGEIARMSLHLVDAVQTIFTVRHKPGYKLKLRVGIHSGPVVAGVVGNTMPRYCLFGDTVNTASRMESNGEPLRIHISDQTKKILDQLGGFIVEERGEVFLKGKGNCITYWLIDAVKKRQLSVKGKSHHPNGNPLLSYLTAPSQFGSTGSLNVRRTDSFRKNIKSTPSPKPKKKVWHKFDVEDGLLGADHTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUV9</accession>
    <name>A0A6P8HUV9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295428</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559088.1">
        <property type="nucleotide sequence ID" value="XM_031703228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295428"/>
    <dbReference type="KEGG" id="aten:116295428"/>
    <dbReference type="InParanoid" id="A0A6P8HUV9"/>
    <dbReference type="OrthoDB" id="421638at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013869">
        <property type="entry name" value="DUF1757"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636:SF1">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38636">
        <property type="entry name" value="PROTEIN CBG20488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08560">
        <property type="entry name" value="DUF1757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559088.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="17866" checksum="6EFF56AB9BE361C0" modified="2020-12-02" version="1">MKFHWTRNMAGQSLSDDDMRVIPHPLLELNVHVTTKTVQACALLGMVLIGPAVRLIRGPRTMGAFTDTAIKAGKIGALIGLPLGHAMTFAMLKKAKVDDDGLYDRCYRLRYNRNQVRIDRLSYLGAVGGAAGALYMGSALSSGAVVGLVGGTLLGXIYNSTIGERHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV57</accession>
    <name>A0A6P8HV57_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116295549</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116295549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559256.1">
        <property type="nucleotide sequence ID" value="XM_031703396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295549"/>
    <dbReference type="KEGG" id="aten:116295549"/>
    <dbReference type="InParanoid" id="A0A6P8HV57"/>
    <dbReference type="OrthoDB" id="10409113at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031559256.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="52255" checksum="FD111630EBC46A3F" modified="2020-12-02" version="1">MARSSIIFRQVFSAKLDSSTAWYALTTENCIGSPRKASLSSFFRVFPNEISKIKLCDLVTRDGSTVQSCWFFHENANKVRVDEVYVATAFGIIGNLFNRRQITEVNTILHPKIQAAIRSIDLEDSILPPEVVPPKVIPPNVIPPKVIPPSSKYTSSSLSYAEQHSLPFFNESFEEVENSEVTGRVKRRKTRAKSNFIMKKVSDLCSSQKESLASVLARCCTDDPQSRPSFARETICQVMDEVAEKKGVKRAFEELISDDLWDQRVAEMRMPDWQLLFLKVQAKISDANWQSIINFTKLGRKGSSNICILPIKNHMKALRSSIFGVAKQIMLIREVPDSLPGYQVSLEQAIVWSAREQRLHGTQSEVLEFHLKLDGRPLFGKDQVSVGIVPGNHPYLSSQSALTVRPLAIANIEESRKEIKVLVRDINRQKDVIKRNGIVVDGKLLQVKFKGKFFVNXYYSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVY1</accession>
    <name>A0A6P8HVY1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EKC/KEOPS complex subunit TPRKB-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116296655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560569.1">
        <property type="nucleotide sequence ID" value="XM_031704709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVY1"/>
    <dbReference type="FunCoup" id="A0A6P8HVY1">
        <property type="interactions" value="1531"/>
    </dbReference>
    <dbReference type="GeneID" id="116296655"/>
    <dbReference type="KEGG" id="aten:116296655"/>
    <dbReference type="InParanoid" id="A0A6P8HVY1"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031560569.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20071" checksum="50532F8B128B496C" modified="2020-12-02" version="1">MAEQEEISVYQLENSTEHCVALSLFVDITNSPEIRKLVMEGRIEATFLKPSMIADPFQVVLAAHKALHLSKLQKTKTKTLHSEIIFNLSPTNNITDSFKKFGLSENDTTLLLAVITTGDGVEKMRAISQHVKGRQVPISNLKTLADQQAIKKVYKIQDCELKVSSLTESVICRMATKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW37</accession>
    <name>A0A6P8HW37_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 14</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deubiquitinating enzyme 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carboxyl-terminal hydrolase 48</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin thioesterase 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-specific-processing protease 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116293548</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP14/UBP6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031556850.1">
        <property type="nucleotide sequence ID" value="XM_031700990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW37"/>
    <dbReference type="FunCoup" id="A0A6P8HW37">
        <property type="interactions" value="3516"/>
    </dbReference>
    <dbReference type="GeneID" id="116293548"/>
    <dbReference type="KEGG" id="aten:116293548"/>
    <dbReference type="InParanoid" id="A0A6P8HW37"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="14">
        <location>
            <begin position="687"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="651"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031556850.1"/>
        </source>
    </evidence>
    <sequence length="785" mass="90162" checksum="98A2055395A84C6A" modified="2020-12-02" version="1">MNEILKDDINDEKNAPVYELTAVLMHHGTSAYSGHYVAHIKDKETNTWYKFNDEDIEKMQNKLKLSGEDETSNEPGEKPAKRPKCSKGYHTSRNAYMLVYTRKTDEDMPKPVVEVPEHLQELVAKDNSKFEEWITEMNRMKDDMVSKGKNLQAEVQSVLQMLPAVGDNYEWISSEWLRIWLNDRIEVKPPIDHSSLLCSHGKLNPEKVPNAKRISTNAADWFYAKFGGFPRLQRDSLCFDCVKSVCSQIRFKFRLAEDDKAIKAILKTKVVPQRVGNWFWIGKSSLFSWKKLATLADNAKNTGRNPLDESGMINNAPIQQATERDTCISTNGSPVNTSRKRKNKSNTCEEDDSLSKEDGLKDLSAVKTMNMDTDSCTGTNNRGVGSCQMDESTSMEDGSRMNESSEEEEEDLMKFNEDLMCEHGNLSANATCRKLIQESIWQRLLYYFDSAREFPEDHPICQQCQVESEDERKIQELNKARATEERVALSNLYYNKHRPDLHNNDEEHSKLCVYAVSNSFLDRWRSFLRNCFKCPRPDSISNEDLLCPHQRFMFNPELRDEDGAREVFSYLFKNEWDLISTKYPYDEIITVTKETTEDKEKPSFITSPEICEDCHASRMLEKARSFENYRHATIFVRKITDEHDPNEIQRRFDEEVTDPDSPQDPDYSSSDNKQKSSSENSKRRSSRHRKQRGEINLTVNSNQTLRDIKLELMKSFSVMPMDQHLSLKSTPLTDDAATLSRLGVRPGCLLMLKLDQPQGGGHPETLLAASTAPEKGFQGTVLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ90</accession>
    <name>A0A6P8HZ90_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296688</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560606.1">
        <property type="nucleotide sequence ID" value="XM_031704746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ90"/>
    <dbReference type="GeneID" id="116296688"/>
    <dbReference type="KEGG" id="aten:116296688"/>
    <dbReference type="InParanoid" id="A0A6P8HZ90"/>
    <dbReference type="OrthoDB" id="5974848at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028461569" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560606.1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="118883" checksum="A5095DB76F419BA7" modified="2020-12-02" version="1">MATFYKISAVLICSMVLLTVQGRVHKKKDASVDTATPIKKEGACVVGEWQGQESSSIPTIPTTMWFNTPSIIEIEAGHYQATGRIIKANYLKERLTLKDINFNTAERTNMDSLLKLDILADTFHIEGEVTFYALQTVKIYARKIVAAKGSRIVFATPEWTQDFATPVGVQSNGVGTNGENGKDGKDGPQVEVFSDTIQGELDISSKGGNGHKGQDGGNGRPGSNAANKADKYGSWTWCKRGGYVSYNIIGVDESVEANKRCNAKNRGSETGNRGGNGARGGNAGTPGRGGNAGSVTLRYRNLKGRVKANVCAGTGVDAANNGQGGNGGSGGTGVQGIRCYAYDMSESSEIKVYDCRKRQRLHAPRGSNGQKGAPGTTPNVKGEDGTVSDSSVTQSTTINTAVKNLFPEGLLLLIRRKAVDLLLGDSKNQEGKDALQFLVRITTGRTDVEYIMKDAQRKLAFVDKDGFDIFGKNSLFAPLVKWEELQNDVNRIKAAAKIYEDTFTKVMNQVNDEENFQQIATVMTSAASQQVNAQKRRLVAARAIDESEKRMYITAIREAETQMENTIVKISSSLKKAQQTAANRLSKQQFFAVLTGITGFLSAEGPYDVIDTAVAIAEHDANKACLTSLDSVIGSVKEWLTFGKYVPLTDSSELDFDKVKVSSVPEMMQAKLEMNKEQFAADLVCLLEEATKPRDVAGLKAEIESFFVLGAARIDMIAKIMDLDNTIGGHNFDIPLLEKTEKAITELSNPTDASITNKLRQTFLDNLLGTYKELERSFMENMYELQKALGFRFLWNLDDVMSSFQRIASESAMGTGQLNGAVELSQVSQRLDNITTKAKGCFSKLKYKTNVQKWSFDNVKDKQMFEEIKTGSATFSIGEDQICKTCHNARLIKMYVELYGTEAQPKDVWDVVRLNVRHLSRAYFRAGDGKIKQYLTPITSLRDLKFDRFRISDEDECRKRKKNADKPVAHFCVEEQDKRLKPMCSHSLSGVPADDLMMGNDECTSPSGFYELKIPVDRALPCKSTTMRDTNCKDIDLTKFTKMNVWMYYIYWSKKYPKDPNDPVCYLQKDSTKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0Y5</accession>
    <name>A0A6P8I0Y5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 34-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562259.1">
        <property type="nucleotide sequence ID" value="XM_031706399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0Y5"/>
    <dbReference type="GeneID" id="116298055"/>
    <dbReference type="KEGG" id="aten:116298055"/>
    <dbReference type="InParanoid" id="A0A6P8I0Y5"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562259.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43790" checksum="21BA10EA9ADDB681" modified="2020-12-02" version="1">MGDASATKDDYLKACADVQKEPNAELLAIFNTAIDDSFTEPCNEFYLKLNGNKRNEWNEMYRKRLVDEDVDILYKTLKPNTFVVLLDLGYNNIGDKGAMILDQLLQETLVLQTLVLSYNDIGPEGGEAIAKGLQVNETLRELKLNGNKIGNKGGMAIAGTLQVNTVLEELDISEVDLKTESVIAMATVLNYNNTLKVLVMNRPLLFSHQEETTVHIARMLKVNIRLKEIHLTHYDIRDFGAERIKENLYENLTLTHLNLSSNNITRDGAKQLAILLKKNTPLEVLNLAYNRIEDDGAVAIAEALASYNTNLTTLVVCSNNIASQGLCAIAKAMKLNISLRGVYIWGNNLEEPACRAFQDLISGSVPRMEPNETDVQPYVVDGVVYLSHLNNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1V7</accession>
    <name>A0A6P8I1V7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116297428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="RefSeq" id="XP_031561511.1">
        <property type="nucleotide sequence ID" value="XM_031705651.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I1V7">
        <property type="interactions" value="1365"/>
    </dbReference>
    <dbReference type="GeneID" id="116297428"/>
    <dbReference type="KEGG" id="aten:116297428"/>
    <dbReference type="InParanoid" id="A0A6P8I1V7"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000001">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1130">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036254">
        <property type="entry name" value="RabGGT_asu_insert-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009087">
        <property type="entry name" value="RabGGT_asu_insert-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07711">
        <property type="entry name" value="RabGGT_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49594">
        <property type="entry name" value="Rab geranylgeranyltransferase alpha-subunit, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rab geranylgeranyltransferase alpha subunit insert-domain" evidence="12">
        <location>
            <begin position="294"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031561511.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="72895" checksum="D3997C2D91C77EEF" modified="2020-12-02" version="1">MEKSGIGIKLIRTRGEELLESSEELSKSSTERRAAKLAELNPNVLSSLVQHGRLKVRTSAEQAAAKQKEREKKMKIYNEATQRVFTKRKNDEHDEEALRLTEQLLSSNPDFGTLWNFRRETFLKLKDENGFDENLEKLCKNELSFLQGCLKVNPKSYGVWHHRQWINEFLPKADWKKELQLCDLFLSFDERNFHCWDYRRIVVKKANITAEEEFKFSTDKIVENFSNYSSWHYRSKLLPLIHPDPSGNPDRIEESALLKEFELAQNAFFTDPNDQSAWFYHRWLLGRAQIPMDITCMYVKTFPGHVTLLVQFSQPIKVSACNTVVKVNDEEIKGTWRNVFSTXQPCQIWICNFSFEENIDSIIVTVPLMENKLTRKISLAKGQEEAWLMSSDCHLLRAELTAIHSSLLENELDSCKMLLEEEPDNKWTILTIVLLMRALDPLAYQDNTENYLIKLSEIDQCRREYYHDLRKKFRLENAIENHWKRGTTSDDELERSINLSNMELTHLYHIHQLMLMREVDLSGNKLTSLDQCNMLQCVKVLKASDNKLTCLSKKHVLRLDDLEELVINNNYITDVKVLDVLKSFPRLAKLDLRGNKVCGLPDYRTKIKTLCPTLKVLDNEILNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2I1</accession>
    <name>A0A6P8I2I1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein RAB5IF homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562013.1">
        <property type="nucleotide sequence ID" value="XM_031706153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2I1"/>
    <dbReference type="FunCoup" id="A0A6P8I2I1">
        <property type="interactions" value="1278"/>
    </dbReference>
    <dbReference type="GeneID" id="116297845"/>
    <dbReference type="KEGG" id="aten:116297845"/>
    <dbReference type="InParanoid" id="A0A6P8I2I1"/>
    <dbReference type="OrthoDB" id="286395at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010742">
        <property type="entry name" value="RCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906:SF0">
        <property type="entry name" value="GEL COMPLEX SUBUNIT OPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906">
        <property type="entry name" value="PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031562013.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14414" checksum="D0AE4F9F2659BB8B" modified="2020-12-02" version="1">MSTQQRKKTTHESNGEVSVSETFHKALKSGSTWEDKEEFLDVIYWLRQILAVIIGIIWGLIPLKGILAIGLFCLINAGVAYVYFNNFQKIDEEEYGGAWELTKEGFMTSFAVFLVFWIIVYSSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I308</accession>
    <name>A0A6P8I308_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116298558</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562929.1">
        <property type="nucleotide sequence ID" value="XM_031707069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I308"/>
    <dbReference type="GeneID" id="116298558"/>
    <dbReference type="KEGG" id="aten:116298558"/>
    <dbReference type="InParanoid" id="A0A6P8I308"/>
    <dbReference type="OrthoDB" id="5985863at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="175"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="10">
        <location>
            <begin position="377"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031562929.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53032" checksum="447200EB9E139110" modified="2020-12-02" version="1">MTSRIKSGNLALQQPSELSSVYLNTRFPIYAVDGSPNGGPSATLCANSAQDNPYWIVDLGKTFIIDEVFIIGRSDCCFTRMFGSEIRELVHLYQAEDNVSLLKCNGDSLIYHGNSNPRCGGIYTMETLSKKSFYCKPRKTGRYVNIRLIHMGILTLCEVEVYSESKAIIDIDQPGPTVVQGLPTALTCPVFGYPEPFVAWVRDGVIHQNTTTTSVFKENELNENRNQSKWECIVSNIHGSDFHQFHITGVSWHRMCAKHQIIATKRTLNDVISSPDQASNDTSVNESVWFRLQHPVTSQSMQIPESCTPSMRCSTQATGWLLGSHPGIQDGVVRRTVCFNWDGNYCKYNTTILVRRCHGFYVYKLQKPSFDVQAAYCAEISNALSPSVIFKHVTVNGGVVNHVIHTERDLDPLECVAVCLSHQSCKSINYHSSSRLCEMNSAARSDVSSSDWMERQGISLYEMIKTIDNGSCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3G3</accession>
    <name>A0A6P8I3G3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116295682</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116295682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559442.1">
        <property type="nucleotide sequence ID" value="XM_031703582.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295682"/>
    <dbReference type="KEGG" id="aten:116295682"/>
    <dbReference type="InParanoid" id="A0A6P8I3G3"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001203">
        <property type="entry name" value="F-box/WD repeat-containing protein 1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="817"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="913"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="955"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1168"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031559442.1"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134666" checksum="6D60F767B2BB182C" modified="2020-12-02" version="1">MENIISSSEVAGVDLQPANASNEPDSKCRSSSKRRSKTRSKVWEKVAWFTRKAKSNRENKAESLEEAGKGVKSPSLSVLRSEEQEVPVLNSAGIKLNSFYKTKTKSGIRKTRSFNYLKRKKLKHFASDANSSLQEDNNKENADPTSTSCQTATGNFHDFAGFGRKCSNTTASSTLLVSEMAKQMSLKQEEQLKGSVRSSLSLPLSLLSLNERPVPDVCSPSCQGLLCGCKPKNKSFSGPSYNSWPRKKRLLAANHSYEAFSPPQKQKRICGLRKTATFSGFDSSKLCLKEFKSDGSELRMGKSTPLLSGTNQIKNQNGLTIGVIHFFKSSGNNYSIVGKDGCIPRAILPNDVKDLDVCSKCSIKQTRDDNTDIDVVGNIGISDTLHSNLCLDAKMCDDTEGLSLTLQSDLLDNEFFAEKEQCSEENRNNTENISKDLDESANNCAIVSMKECFMVKDPFNEVTSPSSQHLITASQHQENISQPDTLKKDIHQLSESMLSSSDNGQVILESQEIISSSDASALDSVHLNSLNEICATDKRTAYAKLDIIREIPDSLAKGNTKNIESPKEYDEHSMAQTKESPESSQASETRIYCIKIEDQVTDFSKEGRINFQAETKLQSPSTLSDLIIEELKDSIYVKENPLSQSEDNSNTSEILCTMTNDSAPESEEKDETSAAEKNTIGDPSLPSNMATSDEGKSISKDENILPKIKSVNSNFSSRVPLKSSGGNKIPENKSKNILGSSLQQTRRIVLKQGKPKVDGPHFKXQTETILNWFSEFNDEQKNILIKKLLEQCELPQMHLLSVIMEPVLHKTCPSNCQDMLEWLPHTVTNAVMSYLDPESLCRCSQVNRFWNSLASNPLIWKELCKSNEWQLSRKTEEKQMILPCGTVQWKKMFAERYLLRKNWLNGRCKVRTFEGHTQGISCVQFDDTRIVSGSTDKTIKVWDLSRDDSHAVLTLAGHSGTVRCLNLNGNRLVSGSVDRSIKVWDLSFESYWSGASCKVTMVGHMHTVRCLQVDDEKVVSGSYDKTLKVWDLKTGQCELTLRGHNAAVLCVQFDDNKIVSGSYDNTIKVWSLDEGECLMTLAGHHDAVTCLNLTQDGRKVISGSLDHNLKFWDLATGKCIGTLDWIRSEGHTGVIRCLQSDSWRIVSAGDDKTLKMWSLETGQRLLTLRCHTDGVTCLQFNDYRIVSGSYDKTVKVWNFSPEHAFLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5K9</accession>
    <name>A0A6P8I5K9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">HMG domain-containing protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC116296186</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560028.1">
        <property type="nucleotide sequence ID" value="XM_031704168.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560029.1">
        <property type="nucleotide sequence ID" value="XM_031704169.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560030.1">
        <property type="nucleotide sequence ID" value="XM_031704170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5K9"/>
    <dbReference type="GeneID" id="116296186"/>
    <dbReference type="KEGG" id="aten:116296186"/>
    <dbReference type="OrthoDB" id="8948380at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039598">
        <property type="entry name" value="HMGXB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040648">
        <property type="entry name" value="HMGXB3_CxC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17609:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17609">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18717">
        <property type="entry name" value="CxC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031560030.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="104104" checksum="E8939F16D2ABC683" modified="2020-12-02" version="1">MERSSGLFTQQDGSEQSVETVILPPATKRGKGTCPGQNCEFSYACRKKPSTCPKCGYYLGGNATDTVKEDTSISFATKLKVGALPENYDLYSVKISRRGRDYRCFVQVSTINDEHICYYEKCRVQRSAALISNSNSFQCEHVKTAKESSIEADVLPLSQTALPSLPFPTSMKEELREYIEKASLKKTPPIQQVSLNNYVLVCARTLRNPLGLLHLRVDAKKNKFSCGQDGSRTSTKPYRSKCVHFCLYGWATLNIQQSSIVSLIPGAQVAHNQLQYSNHDNVSSDIVQTVATHPNKAIQRNSTVQLLKKVVKIPEDATALSPIFKLIESRNAATTTLLDMMRSGKRIELHFNEVAWKTYFEPEEQECLLCSSTLSDTLNVQGSNGEGWLVTMTHILPMTCKVKKCTNGNCMAIYSYHDVQSGLFNIANKILVSLDILFLIREHVKQGVLPSHAVEAIMSMTLAKSPAAAQKINGEKRRYIEQHLFKGYWAYECLTVRNYDDCICGLCGVAPKLEVGESSYRETMSLSGVKIDWPQVQFPTDIPVDVHAFWNELENKSLEQSAFASVDLITSYEGIKIAAFIPPSQCSDTVVNTESLKTSSKTANITGFQGNTSKLAGLVQSGVLMPQSLSQYSHNDLYSLCQRCDIPVNETDSKIVLENHLELGYSYVMSGRSTCHSFTSASNYSGGKVYKMCPHQVLTASKYTVRPESARDHVDLLKSCKYWPPVYLTDIACSVAQHAECRFPALTRHVWGNKQGCFETPSLYDDPQPTSCPELQMPELQSAPTILLDSEDPLIHPTTASKERRILTARYHEKGNTHQLKSCEYHSIELCPELVPYKNCLVQSRHGNRAKDAKRKTIASLNFHHYFLYGRLMDYFSNLAIAKQQLELISKQCHEGQTIVRDKYQRFVIVCSKCFYGGHLAKDCPYNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6I0</accession>
    <name>A0A6P8I6I0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116296440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560315.1">
        <property type="nucleotide sequence ID" value="XM_031704455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296440"/>
    <dbReference type="KEGG" id="aten:116296440"/>
    <dbReference type="InParanoid" id="A0A6P8I6I0"/>
    <dbReference type="OrthoDB" id="5980124at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000002">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF12">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028281946" description="Delta-like protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="238"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="405"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="507"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="934"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="1156"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="1237"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="949"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1158"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1273"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1350"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1384"/>
            <end position="1393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031560315.1"/>
        </source>
    </evidence>
    <sequence length="1399" mass="159585" checksum="BDC4E1034B0F0D59" modified="2020-12-02" version="1">MNFKLLLLACGVLCLKSIAQARQGVKVSLLLVSFTNPSSKDFKNQCCDPLCMQCNYFFEICLSETTPDNCVFSAKTRTWDNTIDIVFRQGKGQLGNSHDNPLVKELLSWKGRLKVSIKVKDYDTLTSADLVDKYSIDIPVTPTAGVLQESWTERAVKGIPSSMVLRYSVQCNRDYYGPQCTTYCIARDDSRGHYTCNLQTGSKMCRSGWYGSDCLTYCMPRDDDVNGHYTCHPTTGSKICRTRWYGRTCNTFCMARNDSGAGYTCDKDGNRVCLSNWYPSNRCDFYCKPRNDSKASYACDTTTGKKTCLTSWAGLECDCRPRNDSTAGFYCNATTGRRICLDGWFGSHCDKYCIPRNDSTTHYTCNPETGAKECLPYWFGKNCDVYCPPQNESTAQTKCSVNNTLICARNWYGSNCTVFCEPRDDDEVHYTCDQETGQKICLQEWYGENCSNHCVPRDNDWFGHFDCGSDGSKRCHSFWHGAYCTKYCKPQNNSEGYYRCRNSDGERICLENWFGVKCLTFCKERDDSTGHYRCNDIDGNIVCLENWYGDNCTVNCVPRNDSEGHFTCDIRTGQKICLKGWTGRHCEEAIPTIPGTTPEPITSQIPPKNKESKGDDSGVELNKLSLALILGGFLLLICITVGASIVICSRRQVKRPAKPFPYLRYQTSGQDSLERKEDTPNENGGDSETDMDPKAKRQSRVPNLLSQYDDEQFRQKDVFINLQEISWNDDGSRKVDDKLIMYNNPLFTERTSVTPDVPSPDPRVDPVTGLRDNSDWVAIFESYESGEVESGGRVSVAFKRYRNPSHRKWNGKCCDVKLWGRCRRCDTYFKICLTEVPNPRSLSRCTLANIRTSKMGHDDIYMKFSTLRSFTSFTGKVGLYVEVWDWDMITNDDLVDRMSLTLYVRRPDPNGQSSSVYPRTLRGRRATMGVEFKVYCSPFYYGPSCTKFCKPRNDRYGQYHCDLNGNMVCHAQWFGPRCNRRCTEHDDQHHGHFKCDALGNRSCRPGWHGKRCNRYCVSYDNDQRGHYVCNSQGVKICRTGWHGSGCKRYCSPKNDNVYGHYHCDTDGNKVCMPGWFGPSCLKHCRANRRVHCDKDGNKVCNTGWFGPSCLKHCISSRRMHCDKDGNKVCNTGWFGPSCLKHCTANRRMHCDKDGNKVCNTGWYGKNCTRYCIQHDDHLNGHYKCSLPDGKKVCLPNWAPPNCKKCKKGYYPPECKRRCEPRSSKQHGHYTCDKLDQKTCLMWWHRDECKTYCVPHHDPINGYYTCDSLGQRKCMLGWHGELCTKPCLSKDYNISGSCQGLKRSCNEGFSLPDCMQCEVGFYGRNCSQSCLLPGEVNVGKVVCNDSGERMCRKWWFGEKCDVYCVPHDDDTNGHYICDKNGRKRCLMGWVIPGCKVKSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7P5</accession>
    <name>A0A6P8I7P5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Methyltransferase-like protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116298857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. METTL23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563291.1">
        <property type="nucleotide sequence ID" value="XM_031707431.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563292.1">
        <property type="nucleotide sequence ID" value="XM_031707432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7P5"/>
    <dbReference type="GeneID" id="116298857"/>
    <dbReference type="KEGG" id="aten:116298857"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF164">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE METTL23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031563292.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23819" checksum="B12781BF05860604" modified="2020-12-02" version="1">MNAEKIFSFEDKGHHLTVKIPEVVHPQYGMFTWPSAPVLAQYVWTNRAQIQGATVIELGAGTALPGIVAALCGGQVILTDKEDYPECLENCKKSCYANSLTSVDVVGITWGEFSPNVLKLPKADVILGSDCFYDPKDFDDVLATVSFLLDKNPSAKFWTTYQERSSNWSIKNLLSKWGLKCVQIPLESFDADDEFVGGSSMSSKHTIQMLEINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8V8</accession>
    <name>A0A6P8I8V8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein F54H12.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116299181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563671.1">
        <property type="nucleotide sequence ID" value="XM_031707811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8V8"/>
    <dbReference type="GeneID" id="116299181"/>
    <dbReference type="KEGG" id="aten:116299181"/>
    <dbReference type="InParanoid" id="A0A6P8I8V8"/>
    <dbReference type="OrthoDB" id="5975932at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031563671.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="52701" checksum="BE49CC3CA71CFB66" modified="2020-12-02" version="1">MNQRHTSSPEAYKLYYLNQAQQRGDGPSSPFFGGKLFQRGYGQLEDEISLIHPKSYECTIDELDLFTISPTQNSVLKKVDVEFRPLSTLNSNTPIEFSIPGNEDCIRLPHTQLYVAGTIKHKDGTALEANERVAPVNNFLHSLWKQIDVFFGSPRVSNPTNTQSYKAYLETVLNFGTGAKGSQLQTSMWNEDTAGSFDDTRVAAEGTNKGFKKRNDLIKESTEFEMIAPLFVDAFTIRKYLLSFVGMKVKLIPSSPEFCLMSGATGKEYVINLTSAVLKVRKMEIAPHIIMAHEAALMKSPACYTIRRTECKAFTIPGTTPSITKDNVLDGQIPKRFVVGLVRASAVNGHLKQNPFEFKLFGMSSIGVYIDDEHAGGKLMKLKLTANGGHFIEAYQTLFTGTGKFRLDNGNSITRSDYYQGYGLFVVDLTPDGCDSPELLTLRQKGNLTLEIVFDRALTEAINLFCYAEFDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAS6</accession>
    <name>A0A6P8IAS6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116298122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562352.1">
        <property type="nucleotide sequence ID" value="XM_031706492.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IAS6">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GeneID" id="116298122"/>
    <dbReference type="KEGG" id="aten:116298122"/>
    <dbReference type="InParanoid" id="A0A6P8IAS6"/>
    <dbReference type="OrthoDB" id="5990101at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2014"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="245"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="354"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="462"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="885"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="1109"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="1215"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="1322"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="1427"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="1535"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="1644"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="1752"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2087"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2090"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2103"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1388"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1494"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1602"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1711"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1777"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1790"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1821"/>
            <end position="1831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031562352.1"/>
        </source>
    </evidence>
    <sequence length="2138" mass="235912" checksum="82E1B274F583B1C9" modified="2020-12-02" version="1">MEEKAILTIIVFIGCGIFLCNVVEANVRLLNGVKTNALYFGILQVYHNNEWGTVCDDGWNINNTKVVCRELGYQQGIAKHSGKGSGRTWMDDVVCTGNENSILSCRHSGWGLEDCDHSEDIGMVCYSDKLPNLAFRWANNAFADAGRLEVRYHGTWGALCTDNIDLEDAYVVCRMMGYSQALAVLKMPTSSSAIKFSLILSCNGNENSTKKCSTAVLNKINSCNTNMESWISCKSEISVHADAAVRLVNGSAPNEGRVEVRYYGIWGTICDDDWDLADAHVVCRMLNYSKASWAGTAKVKGRGPILLDDVHCRANENTLADCRKPGWGQHDCGHSEDAGVKCGNMTEEESVVTARLVERKEKHVGFVEVRYNGTWMPVCDDSWDILDAHVVCRMLGYKGAQAPIRQYRQEVNGLWMGGVECSGDEVSISECYHRGWTNTRCRGNYYAGVMCKVTKDLPPIQIRLEERPKPDSGRVAVRYGNIWGSICARGLEMKDALVICRMFSYPGVISGYISQSVNGTIWLSNLECNGTEKSIADCRHRGWGQTTPCTHDSDIGVNCKAADAPRFQINGTNAITKSTVEILLNNSLTIDSGLQSLYQVAVEKRNIEQRLKSYEQPPPFVYSEVNVTMATHMGNDSYITAEILSPITNLTIGDGQYYHGYYNAPLEPGSMYRVHIRIVTMAMEGEQERVNGHSNFVAFTTKSNSMASVKGVTDQETKKNTYNNAVLGFSVILILLVCVIVGLIAYCKIKLKNTRKKYKTANAAELTEITNPAEPNGQLDCYYQPLDRKYESAEQKESCDYENVTGLRMQRYQVPKPVLTFSTIPYSTYHSHIVIRSGEADGSQSLHGLFIFPVVVVNFDRTCKICQQQKQRYWQLYITIDFVNLDITEGAAANMTLNFPATANVSLPYGILNVYHNGQWGTVCDDGWDSNATNVACRQLGYSIGVASFNMGDGTGQIWLDDVKCNGNESSLDECSHSGWGVHNCGHTEDVGVICQSVIHPVIVRLSGGSNSKEGRVEVRYNNIWGTICDDGWNINNANVICKMLGYQKAIKIKSFGPGSGEIWLDDVSCTGSETSIDKCRSNGWGSHNCGHGEDVGVICLQGSPDVAVRLTSGSVSNSGLVEVRYYGDWKSICDTNWDIMDANVVCKMLGYTQGAAAVIRNYQSSDSVWLSNVRCSGRESSIANCNNVDWGQGSCGNNKRANVLCKSGSSNIHFSLSNGAVSHSGRLMIRYFGTQGSVCADNFDIQDAHVACRMMGYSHAITVYKQPQSDRMPVFSLVMNCNGPETSIQQCGFSLYEINACRSNNVVWIVCRPTGSWTTRIRFQGGSSSMEGRVEIQQYGVWGTVCNSHWDIRDANVVCRMLNYKGAMRVYTAGGGTGPVWLTRLGCKGDEKDLLNCTHSGLGQTGSCSHGNDAGVYCHQYPNIQVRLAGGGSPYIGRVEVKFNNIWGTICGSYWGIHEATVICRMLNYQRAIASIRYFGGGRDKIWLRNVHCAGNEESLELCSHSGWNSYSCGHDADVGVNCNGSSTGPNVAVRLVDGSTPNQGRVEVRYYGVWGTVCRDNFGWANAHVVCRMLNYTKAMLYGTANVRGNGPILLDDVKCRGYERSLEYCSHRSWGQHDCGHYADIGVRCGNLTKDELAVEVRLVKTVQNLSGEVEVRYQNTWRPVCDNTWDILDAHVVCRMLGYQAALAAVKRYRRGRAGPWLSQVQCNGAEKSISECYHRGWINKLCTGYFTAAVLCQHPEGSLPIDIRLEDGNLPNIGRVAVRYGNVWGTICNRELDINDAKVICRMLGYPGTSKVYPKSNFRPGNGTIWLSNLDCNGTEDSIIDCRHPGWGQTICSHDDDAEVVCEKAGIPRFQINNSNAVTESTAFLMIEATGAIDEALNSSYQIVVVKVDQNVIFSSMDQPQQMLPAMIEHFTTATNNGSAFYVTAEVEYYASSFNFTVGDGLEYNGYYNAPLEIGCVYKVYLRIVTRTTTGRKVYGDSSFVAFKTKSSIGKGVSGSKIFQASGSIVIVLSVALVICIVLLIGCSNLLRRRRNERVDNKVKSQGNEAIEMSSVHSPMYGNTEGIYQTLLHLSPPQIEESHYANVSDSEPKQCQMSSGTSVGGNTSTSKKEEGLYENVEDVKRATPLLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICM6</accession>
    <name>A0A6P8ICM6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein kinase TNNI3K-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562780.1">
        <property type="nucleotide sequence ID" value="XM_031706920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICM6"/>
    <dbReference type="GeneID" id="116298442"/>
    <dbReference type="KEGG" id="aten:116298442"/>
    <dbReference type="InParanoid" id="A0A6P8ICM6"/>
    <dbReference type="OrthoDB" id="5963061at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="95"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562780.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37441" checksum="14A9EDBC6B7217C9" modified="2020-12-02" version="1">KQEKVRHKAKKREEERRERLQLKSKLVSSIGIQTDQVASSQIKSRGAQMVIASRERNPNVVGKVNTQTAKPVVVSKPAYKSAPLIRNQDLTKPAEGYPVSVGEGSFGTCEFMFYRGNIPVVVKSYKSHVSRDEVNAEASSLMELQKPSPHPCLPLLLGIHVADKPYLLVTQFHGNGQTSHTVSSAIRASLLESGREWYLFLEKLVKAVSFMHSKQWLHNDIKHNNVVCHLSQKIWQPVLIDFGKSLKFVDARKTSMKRCPKDYPWIAPEIVKGEARKSIEGDVFSLGYLMKYVAHRVAECRSAHFSDLYNKCMSIIPSHRPSLQFVARELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICU7</accession>
    <name>A0A6P8ICU7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC1 domain family member 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTPase-activating protein RAB7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction. Interacts with ARMC12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562960.1">
        <property type="nucleotide sequence ID" value="XM_031707100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICU7"/>
    <dbReference type="FunCoup" id="A0A6P8ICU7">
        <property type="interactions" value="2771"/>
    </dbReference>
    <dbReference type="GeneID" id="116298586"/>
    <dbReference type="KEGG" id="aten:116298586"/>
    <dbReference type="InParanoid" id="A0A6P8ICU7"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF645">
        <property type="entry name" value="LD27216P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="10">
        <location>
            <begin position="310"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031562960.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="80855" checksum="8915CFE6AE6FE9D5" modified="2020-12-02" version="1">MAAASQAKTETKEKVVYSQDGVFVHTAVPTTTHSANIIPGRVSLIEKDNSTFVDWSPCDFGDDDYELQSSDYSEWNLVTQNKQKDEKNSPKKKEKSKYAIHFDIKKLHSIRRSDPRLAWSYIVFILKDSNTLPALHFHSGGIMNLIRNLQRYIWITRSATNHKLFLVDDEQKALRMSLTQLQLFPEGAPQTSYISHFFNAAYYDGMDALSKVTKYFRDTMDVMQSGPNLAEMDDPLVISTTSPRKDAEFEDLGEATSLSERNIPHRRCLGEVPMVSREEPLREEGWKSMLDSNGRVINIKKLHDKVFKGGIDKGLRREVWKYLLGYYKYGCTFQSRFALNKAKEEEYRTMKTQWQTISAKQEKHFSEYRERKQLVEKDVMRTDRTHPYYIEEPNNKNITTLNNVLMTYCMYNFDLGYVQGMSDLLSPVLFIMDNEVDAFWCFVGLMKKVAHNFDENQEGMKMQLHQLAVLLKFVDPLFYSYLEQHDSGNLYFCFRWLIINFKREFQYDDIMTLWEAMWTQNLSPNFHLIICLAILDKHRQLIMEMNFGFNEILKYINELAYQIDVNETLIGAETLCLQLLAHPELPEEVRAIVTGRNVAVMTPDIEKPDPLLLRMHGRDVSRLLPVTEERGPEQRNGASNGNDLCSSVINDLSIVSVHEDGTCHDISSKPLTNNVPLNVQTNGSDDEIIVLSEEAENIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID03</accession>
    <name>A0A6P8ID03_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">5-hydroxytryptamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116298712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563110.1">
        <property type="nucleotide sequence ID" value="XM_031707250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID03"/>
    <dbReference type="FunCoup" id="A0A6P8ID03">
        <property type="interactions" value="700"/>
    </dbReference>
    <dbReference type="GeneID" id="116298712"/>
    <dbReference type="KEGG" id="aten:116298712"/>
    <dbReference type="InParanoid" id="A0A6P8ID03"/>
    <dbReference type="OrthoDB" id="5976768at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031563110.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40928" checksum="6ABA32BE059444BE" modified="2020-12-02" version="1">MPGINQSDATIMNCTSKDGWEAYLQETNTGFWVLKIIIAMVTVIGNGLVIFLIVTRKKLHTTDNWFILSLGLSDLLIGIYITPSELICKFFLACIKQPDVRSFVPNFLIISSICNLCALTVDRYVAILHPLRYVVLMTSRRVKQLVFLAWFLPLIIAGASLILDMSQYKNTVGSYLIVFNIVLVSLIPSLALTIVYLRIYIVVLNQRKMTKSQLTINMSGQPEDNERKSRKRLERSRDRSSIRVLGIVITFFVLCWQPSTYRAICEHFKVCHVTLAVVQTSRILILLNSCVNFTVYALLKRDIRKEFLAKWKTTIQYYRERNSSISTRSVSSTLSTFSTSLRYLDQKIELAALNNNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDM2</accession>
    <name>A0A6P8IDM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116299094</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563590.1">
        <property type="nucleotide sequence ID" value="XM_031707730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDM2"/>
    <dbReference type="GeneID" id="116299094"/>
    <dbReference type="KEGG" id="aten:116299094"/>
    <dbReference type="InParanoid" id="A0A6P8IDM2"/>
    <dbReference type="OrthoDB" id="6418794at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028085985" evidence="1">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563590.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31848" checksum="7DD674E77FD08993" modified="2020-12-02" version="1">MRFEVLVVLALMFAIFSDGCRIPSEPTNLAAHDIQSRTLTISWRRPKHACNSTQLNYTVYYKVQGERVLQEVEVVSVTKVKLFVKPYRKYEIFVMARNREGFGPPSVKTYALTLQEVEQEGGSCVSDWVKMSQHVVCFEAKGNSFGSFHNNVRSGLVVAIKLEHVYGHVSCAGTSHNSHWGCGNLNGKYGINSLNVVVTDQLNRIIFPKEQYIGLPPRIWYGMPFMDTASSKELIFTDFAQPFYFPEGKQMRIWYGEDLKDSSESDNVGRACVNVYAKFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE81</accession>
    <name>A0A6P8IE81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116300285</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116300285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564982.1">
        <property type="nucleotide sequence ID" value="XM_031709122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300285"/>
    <dbReference type="KEGG" id="aten:116300285"/>
    <dbReference type="InParanoid" id="A0A6P8IE81"/>
    <dbReference type="OrthoDB" id="5983920at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031564982.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="86244" checksum="41234D69190257E7" modified="2020-12-02" version="1">MEVCCSFKTIVGGICGSDSXDQKQEVHVIPLVSCSRDITKHLASFGFSGPENEVDLILSRAAIFTAPENAKDMTICPFHRGKLGLGWTRGASTQCRVPPALSQHSTTTKKKNWPKGERGLGKYDSLHVLQKTGVFIQCGSGVCRKCRELLKNLYTLDVDELEYQLKKTTLDDDEDDEVIFKTPRHKSNPVLRTPQSAMASTVFSPSEFSQVSELSQMEDPVIISPREKLNAFLASRDVSPIRTSMTTPWDAAAERTKRHYIRKAKQVIHAALEEIAPENSEELLSAVKERAMGEEIDLDSTLLEALVECYENASHWSSRRQILSIIADKISFPTLQKWIPGISRYRFTIARHHLLLHGRGSEVPQRDQHQTRMRASPEQLDHFLAFITSSRATQDLPFGEKTLKLSSGTEIKIPNVIRTSIPEQIVKQYERYCIETGFSSPLSRSSNLRILKVCSASMRKSLQGLDYFSADGAKAFDDLQEIVEKLGDCYQRGMSWSKEISSMLKLAKRYLKGDYKVHISSSSRVPDHCRPYALSHSTDPDYLNSCKHKHDLSCDRCNTFPAAVQAIESALDEDDIPLEEKEEMKFIVAQARKNIEAWKAHLLRSVNQDEARLDIIDKLDDFSVLVVLDWAMKFIPRRYRESQADWFGKRGMSWHVSVAMRKVDGKLQNLTLVHVFDKSNQDSFQDSLFVIAVIVDVILQLRRAMPDLKSVSFRQDNAAYYHSSPTILGVQNLARKHKVDVRMDFSDPQGGKGPCDRKALLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFY5</accession>
    <name>A0A6P8IFY5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly 2 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">HESB-like domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116300851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer; forms a dimer of dimers with IBA57. Interacts with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57 complex; [2Fe-2S] cluster binding is absolutely required to promote the complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565670.1">
        <property type="nucleotide sequence ID" value="XM_031709810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFY5"/>
    <dbReference type="FunCoup" id="A0A6P8IFY5">
        <property type="interactions" value="1135"/>
    </dbReference>
    <dbReference type="GeneID" id="116300851"/>
    <dbReference type="KEGG" id="aten:116300851"/>
    <dbReference type="InParanoid" id="A0A6P8IFY5"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="10">
        <location>
            <begin position="65"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031565670.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19789" checksum="6C22DBE5FC9BD556" modified="2020-12-02" version="1">MASTRIFCCGRTLLKLRHFYPSHKRFCSQKLLQTKFNYQRTRNSDLYRRFGSTSTGEGEDSERLLHISEKCVQQMKKITADENDKDKFLRVLVEGGGCSGFQYVFKLDNKQEDEDRVFEREGVKVVVDEASLEIINGSTIDYKEELIKSAFAVVDNPKAEMGCSCGVSFSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGI0</accession>
    <name>A0A6P8IGI0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nose resistant to fluoxetine protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565826.1">
        <property type="nucleotide sequence ID" value="XM_031709966.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300979"/>
    <dbReference type="KEGG" id="aten:116300979"/>
    <dbReference type="InParanoid" id="A0A6P8IGI0"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028385413" evidence="2">
        <location>
            <begin position="21"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565826.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="79451" checksum="C39057FCACA3EF5A" modified="2020-12-02" version="1">MQKCWHFWVIFIVLFVGCQSLTRDVVKQMNDLDPRAKEVVKHLIALAENKSTVVPHVSDQCTWTLGNFTNSTSIGKYIDASGKLPSGIANGNLLSIGSYGLCESIPSSHYCMVNFAAILGKKVVPIRWGLCITNKCSESDIAYGLNDIKDLFHLQGIYISTQANPXSVYCAKPSEYSASAVCCIIVCAILGLLCLIGTLLDLYENPSLAVPLEKENQVQVQNGAVPHGDDTEQLLHSDQLNTGNSETVHVQYETKKKSIVVKILLCFSVVQNTKKIMDTDVPPGAITSLNGMRVLSITWVILGXXXXXFSSFVFSDNLGPTFGIVHRFSFQAVDNAFLSVDSFFFLSGLLVAYLGLRRMSKNDGHLPFFQFYFHRFWRLTPAYMFVIWFYTTLEPHLNKGPFWYTHQLGNPCNKYWWTNLIYINNFYPKELVKECLGWSWYLANDMQFYVISPILLYLMYRLKNVGLFVGVGGMIQSSIIVTGVLIGYYDLPIAMAGEFEGTTNNXGNMYTNYVYIKPYCRITPYLVGMALGYVFFMDKKHSFIRKFNPNKRWLLVLVGWLVAIATGISTVYGMYSQYKVNGKPFSKAENIIYGSLFRFAWAVALAWVIYACQTGFGGLVNRILSARFWIPLSRLTYGTYLVHIIVIXVFFGGFQHEITYTDTLLVFYFVSFVAVSYGIAFILAVVVEFPLMQLEELFLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGL9</accession>
    <name>A0A6P8IGL9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cactin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565952.1">
        <property type="nucleotide sequence ID" value="XM_031710092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGL9"/>
    <dbReference type="GeneID" id="116301090"/>
    <dbReference type="KEGG" id="aten:116301090"/>
    <dbReference type="InParanoid" id="A0A6P8IGL9"/>
    <dbReference type="OrthoDB" id="5975790at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="2">
        <location>
            <begin position="187"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565952.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="32341" checksum="B1AE5A724D268807" modified="2020-12-02" version="1">MAGGDKKKKKRSERSRSRSPRRRDRSRSPRRRKRRDSSASTSSSLSEDERRREKGYQKNSGKIPKDKKKEKEYYKAHETPEEKRARRLAKKEAKERKRRKEMGWNDEYEGYTNTDNPFGDAHLLETFVWHKKREKQGETHLTEEEKRFTDKKRQMDTRKQLERVRERRTEREREMMLREEEKERMQREKESEYYSEWEKQEDKFHLNQAKLRSKIRIQDRRAKPIDLLAQYISAEEEDLDIKMHEPYTILVVGLLFNNYSPKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGV7</accession>
    <name>A0A6P8IGV7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab proteins geranylgeranyltransferase component A 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116301180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566062.1">
        <property type="nucleotide sequence ID" value="XM_031710202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGV7"/>
    <dbReference type="FunCoup" id="A0A6P8IGV7">
        <property type="interactions" value="2354"/>
    </dbReference>
    <dbReference type="GeneID" id="116301180"/>
    <dbReference type="KEGG" id="aten:116301180"/>
    <dbReference type="InParanoid" id="A0A6P8IGV7"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000003">
        <property type="entry name" value="Rab proteins geranylgeranyltransferase component A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001738">
        <property type="entry name" value="Rab_escort"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016550">
        <property type="entry name" value="Rab_ger_ger_transf_A_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00893">
        <property type="entry name" value="RABESCORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="650"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031566062.1"/>
        </source>
    </evidence>
    <sequence length="718" mass="80087" checksum="D6995688CE364400" modified="2020-12-02" version="1">MEEDFPTEYDAIVLGTGLPESVVAAALARVGQKVLHLDRNDYYSSQWTTFTFDGLLKWIEENQTTAPPEGTTSSPEENTDSCDRQAFPIPHKSNTISNLVTKSYFRTTRKQEEKEETSKTEVAEVKENEPNRNEKDNQSTDQPEQSEQTLTRDGEGERESEDEHNEEQAQAKAEEQAKEAESDSKPTDAQQETAIDSSDAHSSAEDSKTQENISDTNRGSSAEEDLTETEETIEENQPPQIPEFFRQRAAPKPPVNKDMIYEDFEQYFRQFNIDLAPKMLFSRGPLVEAIISANISHYAEFKSVNKIVTYLNGSIEDVPCSRSDVFSSKLISAIEKRTLMKFLTFCIDYENHENEYHEFVDKPYVEFLISRRLTPNLQHFVLHAIAMATTRTTTIPGLKATKAFLQSLGRYGNSPFIWPIYGIGELPQAFCRMCAVFGGLYCLRKSAECVIVDPSDNTCTGIMLDGQLLKCRWLIIEHSYLPNTWQKETTQFVSRAVFITDKSLKVSDHGNVTFLAMPKPNNGGQIKVYELDSSTAACPRGLYVVHFVTESCGTAQEDLQDTAEMLLHFPTSDDDRESTKPVVLWSMYFNHAASDQTTVQDTLPSNIKMTVMPGAMLGFHQAMQQAKTIFQSICGTDEEFLPAIPNPEDIIMDDVNEQPGNSVGIGTTPSDEEAQDGAGDPDGSDHPHDVPESSTDKDVNISDASNAPDSDATEGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH51</accession>
    <name>A0A6P8IH51_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Symplekin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116301216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566101.1">
        <property type="nucleotide sequence ID" value="XM_031710241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH51"/>
    <dbReference type="FunCoup" id="A0A6P8IH51">
        <property type="interactions" value="3212"/>
    </dbReference>
    <dbReference type="GeneID" id="116301216"/>
    <dbReference type="KEGG" id="aten:116301216"/>
    <dbReference type="InParanoid" id="A0A6P8IH51"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="128"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="886"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1175"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1187"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031566101.1"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135217" checksum="8795525053929562" modified="2020-12-02" version="1">MAAIGRDVNNSNRLSEASQFFNREDMDTSGEYQAEDSTTEKVIDLLNQAQLEKEGKLGCLKQVQEFIINKDPSLLDNFLDEILVFQQDKSADVRKFVVGFIEEACKKDVELFGKVLGNLALMLNDENVAVQKRVMLCITQLYKYALQYVCKKRVITEELEQMWELLTDIKNQIISMLESDNDGIRTHAIKFMEMLVLVQSNKTQDSESTKKGEADFSLDSIPRNHPLVRMPELREEGGTTLEALLTLSASPTISSVNLMASLGTLSNIARQRPIFMSTVVQTFESLHANLPTSLSKSQVSSVRKNLKLHLMNLLKHPSSVEFLPQITTLLTDLGASQNELQKNMPKPTPESLKRRAENENAAANKKSKLLDMDDPDIISMTTAEAIDLTAQDLIPLLDKDNVTNLVLISMLSLPDNLPTNFSDTYTPIAAAGGQAQVAHLARLLASQMTGVGVGVGFERMEALKKAQDPRIKKESNKSIPVIGSDSNWDADAENENSGDKKDSALQRILSGQIDVLKDKGKTEGKKIFQPKEAAVPQLRMRKIKAFKLSEVTKDMSLEEQHKMLMAAVDRIIKAENSAVRSGVQQERIKLLIGLAIQAGGDVREVLHNYIQEDPRMHYELIQSWLYQEYLMYEINQEEGYPPDLSMYNECICRLLEGLQQRMDPKDKLFTRVVLEAPIITEQVMLMVKIHCENPETLQVGFATLRDLILKRPATQHQHLQTLLELTTHEKEQVRVQAIHSAKKLHTRPEFALDIETYAMSSLELLLNEKAPVEEGLEPKEWTDESIKICLYLYLALLPQNHQLFHQLAVIYTASSQMIKRVIIRHLETPIRAIGMASPDLLHLVENCPTGSETLIARILNIITDKVTPSPDLVKKVKDLYHRRVSDVRFLIPVLTGLEKQEIIAVLPKLIKQSPNVVKEVFNRLLGCFHSEGKVSGTSPLSPSELLVALHMIEPSKKANANESKGDIRSVMKAIRYCFDEKTIYTQEVLAIVLQQLMEVNPLPTLFMRTVIQSLSICPRLIGFVMNLLSKLITKQVWKQPKVWQGFVKCCQMTKPQSFSILLQLPPRQLESAFEICPELRDNLVTHVQSFTPHQRAHIPRSVLQILDKEKKIEPEQIDKEQVDPKQDNIEIKDELSTKKLQSQSSEDRKDRRKSRRSHSGSPPPKKERKDRGEASDSEGEIDDSETETVHVKQEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHB1</accession>
    <name>A0A6P8IHB1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116301273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
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            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="6">Tentacle</tissue>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
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            <taxon>Actiniidae</taxon>
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        <scope>IDENTIFICATION</scope>
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        </source>
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            <begin position="164"/>
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            <begin position="268"/>
            <end position="279"/>
        </location>
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            <begin position="280"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="291" mass="33099" checksum="7CA62FFC3613C291" modified="2020-12-02" version="1">MAKHYASGLGHVFLVRRQSYIPTYFSIHEFQLVQNTSDSEFLSETPASVEDNTEYDFEDYAARLLPDQGTLKSQLSTSSEYSLSWLQNLAELETQSATPTTRLRSSGLAKLFSCNVSKMSYETKSKLECDGYFGCPEEKHLAKENVATFPRRRHPVCIIPWKKRQPSVKTSRKKKTTTKQTKPKPPTRSDSMDAYYVTKVDCVTSTLEKSKVNGIKLRIRPKIPLQSQSTKSHPAMFYSYFVSKGCQYRKACAPKRRSCDGFFGCHDGEDTKECKGECKGKRKGKKKQSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II56</accession>
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        <submittedName>
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        <name evidence="7" type="primary">LOC116301471</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="7">Tentacle</tissue>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="F:histone binding"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNO"/>
    </dbReference>
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        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF33">
        <property type="entry name" value="PROTEIN WITH HELICASE_C DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch AAA" evidence="4">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Strawberry notch helicase C" evidence="3">
        <location>
            <begin position="283"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="5">
        <location>
            <begin position="604"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="966"/>
        </location>
    </feature>
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        <location>
            <begin position="934"/>
            <end position="950"/>
        </location>
    </feature>
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        <location>
            <begin position="955"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF13871"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031566399.1"/>
        </source>
    </evidence>
    <sequence length="997" mass="110553" checksum="E613A5860A9C3A77" modified="2020-12-02" version="1">MDWCGGEAFDGCLIFDECHKAKHFIPGKEENSTKVALAVTTIQRLLPKARVVYCSATGVTDVKNMAFMERLGLWGVGTAFRSFQSFLDSITKRGLGAAEMLAMEMKASGMYVSRGLSFRQAEFMNAEAVLTDDQRKVYDTSVHVWNEIKTSLEYAVARTKSATPRLWSQFWSCHQRFFKQLCMSMKVPTIVQEAKTALQNNMSVVIGLQTTGEASLESELNRNGGTINRFISITEEIMTRFILQFFPTKIETKDGTVVEDKWSVTAKSLLLGFIKKIGLPISPLDDLIDQLGGPGHVAEMTGRRGRVVRTASDREPHYEARESDSTQVESLNIQERNHFMDGSKLVAIISDAASTGISLHSDLRVANQKRRVHFTMELPWSADKAVQQLGRSHRSNQRSGPIYKLVTTNLGGERRFAAAVARRLQSLGALTKGDRRAATGADLNEFNFDTNYGRSALRSMYQCISSSNLQPGVSLQQVIAGAQISTAYELDSFHETLKECIQMMGLADPGSSTVKEKDSGDVARFLNRILGLSVERQNMFFSYFVECMNAVIEGAKREGRFNEGVTDITGSSIKMIDKPRPVFTEVQKCIMPTHHVILNVDRGVDWESALSRFNHSSKADLNGFYCSKREQKHQRFYLLALQKESSTHLFNIIRPNTGQSPFEEEKKDLLHKYQKISPEEAESGWRAQYDKTKDYCFHGPNCKSGALCRVGCRISQVSLLCGGIVPILSTLEWVVARNADKIGLTRENRTLRVVRVELDDGQRLVGLRYPEQLIPEVTSLLKEQHINDRLLENKSGSLSIKDSLKSTALATEESVAAINNKTLAKAINPPITIKTFFRPVESSDQTEIKAKDVENPECNPENTDGGELVVVDKSTKDCIKETKFNGALTSSYFGAPKATGSTASKVGAKSSGAKTSVSKRGRGGKTSLKRPMSSDVTGSTSKRQKQSSIFSALGRGRENDVTDTEKSSMTCPICRKVFEEGTKNADINAHVDSCLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIL5</accession>
    <name>A0A6P8IIL5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116301635</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566579.1">
        <property type="nucleotide sequence ID" value="XM_031710719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIL5"/>
    <dbReference type="GeneID" id="116301635"/>
    <dbReference type="KEGG" id="aten:116301635"/>
    <dbReference type="InParanoid" id="A0A6P8IIL5"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="104"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566579.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="47360" checksum="5EB622DD81428E36" modified="2020-12-02" version="1">MATSISSLLPMRQSSIMCAKHIQGFLHKNIKRLVLLTSSRCKSYQAFQTSPQDELFSPLDPCELASKKKYRLAGIKYLPDSDCKEFPEFLANPRQGLPQAYKIQHADQFSISEWAQHCRKLLDEQLPKYGVVFFRGLPLSNEEHFTLFSNALGYTAIGYEGGTTVKPNYGKAKSTFISSVEDKAYTMEPHSDMTYWPVYPSKVIFYCDVAPEEGTGGLTPITKISEVMERLDPKLVQKCEEKKIRYHRYLHNGKGYLPWQVTFRTDDRKEVEKYLEANKLSYKWHEDDSLSYWLNLPAIIRHPVTGEKVWFNQYDSHHCTYIKHHSSPMLKELTFESDFHYPTHTTYGDGTDLEPEMLQHIRAIKWQCSVGVQWKRTDMIVFDNLKVMHGRMSYTGERRLLAYICRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ85</accession>
    <name>A0A6P8IJ85_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgin subfamily A member 6-like protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566926.1">
        <property type="nucleotide sequence ID" value="XM_031711066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJ85"/>
    <dbReference type="FunCoup" id="A0A6P8IJ85">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="GeneID" id="116301897"/>
    <dbReference type="KEGG" id="aten:116301897"/>
    <dbReference type="InParanoid" id="A0A6P8IJ85"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566926.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="33041" checksum="31B79E113EB06CAD" modified="2020-12-02" version="1">MWQSKNRGSPVPEYLELQNIDEQEATTRETVEWATQELRMRYPNFEADDIKLTERGNKVLISVRDMRYPDANRWTKPQLLFDDSGSVKVNVARLRGFQLATRSALERLATLNKRVALEKRAEGLQETLDEREADYMRQNQLLADAQKRELDDKNQLIVQMKEQRDKALHDRDRAQKAFKLALQDLNMSKEEAKNLHVTIANSLEERRQLVAEINTKEEQIRQMSQAIEDLEGQIEQQQEIINDQACPEEEREAAQKESETLQGKFAVLCDRRRTLPQFLDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJG6</accession>
    <name>A0A6P8IJG6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301655 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566603.1">
        <property type="nucleotide sequence ID" value="XM_031710743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJG6"/>
    <dbReference type="GeneID" id="116301655"/>
    <dbReference type="KEGG" id="aten:116301655"/>
    <dbReference type="InParanoid" id="A0A6P8IJG6"/>
    <dbReference type="OrthoDB" id="5982856at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028044026" evidence="1">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566603.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21930" checksum="4F6970A41B8EE434" modified="2020-12-02" version="1">MIFRMFKIWILISLRLMMMFTLAKMTEGLECKRSSSVLNGTPCRHNGEVVSDRKACEAMSPKCCSFSVGFLSCFVNKDYKENQVCNKKEISLVEQLAIDSDKHDELFAVGPVLSTHQVVSELHCLDLCYRNHLCNVYNYQYGGRRSKTKVCELLLDVDTIGTKRDFRYRMVDHNERKVLFTNSECKETQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM85</accession>
    <name>A0A6P8IM85_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: uncharacterized protein LOC116302726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567949.1">
        <property type="nucleotide sequence ID" value="XM_031712089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302726"/>
    <dbReference type="KEGG" id="aten:116302726"/>
    <dbReference type="InParanoid" id="A0A6P8IM85"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000462">
        <property type="entry name" value="Glyoxylate reductase (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567949.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19850" checksum="F273526995412DBE" modified="2020-12-02" version="1">FGQQVTGGTIGIIGFGSIGTAIAKRAKTFDMRILYHSWTRKKSLXEHTSAEYCHRLHDLLKQANFLFLCVSLTSETKYLISASELSIMKPSATLINVSRGDVVNQDDLVKALQTGQIQGAALDVTSPEPLPRDHPLLTLPNVIITPHNGTAAEYRRIKMVTIAMKNIVAEIEGCPLLYPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INM0</accession>
    <name>A0A6P8INM0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Histone H4 transcription factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568474.1">
        <property type="nucleotide sequence ID" value="XM_031712614.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8INM0">
        <property type="interactions" value="2124"/>
    </dbReference>
    <dbReference type="GeneID" id="116303137"/>
    <dbReference type="KEGG" id="aten:116303137"/>
    <dbReference type="InParanoid" id="A0A6P8INM0"/>
    <dbReference type="OrthoDB" id="10039931at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF18">
        <property type="entry name" value="EG:115C2.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568474.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66845" checksum="A162EE0151912BEE" modified="2020-12-02" version="1">MPRKKGSSQQKTQEVLVNLDCEWRDCQHQIPFHNNGDFLDFLSHVEQHLQEILPGYKNRHSLDSIPEDFVCPWRDCGWDAPQSTNELIRHVLFHPFHTNIKAVGAKRKVTAKLSDCTLDPQGKNLVPDLQNPFVCEWKDCDLEINCPYWFYLHVESHVMALDAQRIDDEKGDNQVFFACEWKGCKSTAKNHYKLKEHCRSHTHEKVYACSTCGGMFASMSKFTDHLTRQNTSEYEKYQCSHCLKYCGSQRILRDHMRHHVNNIKCTFCDMTCPNQSALKQHIKFRHSDERPYECDLCSSRWKTVSDLRRHRECHNSVLSFQCSVEGCDFSARSVQTLKRHFKVEHEGEELAKYECHICRARYTRGTGLTQHLKSKHKFRWPSGHPRFRYKEHEDGIWRLQTVRFESLQLSQQFNDDGTNMNDENSSQVTSSPTEFSYLQFETLDSPSVASLGTSNGVFHTTNNQYVFVNNGENLDGDSTCSSDNGMEERSRTMQKSIXQNGFQYIVVPRENELEEENSVNVQSPGINTSGENTSGPLRNKISTVRHHPYQRPPSPSLDVPQTLLALQEAALRLASQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP07</accession>
    <name>A0A6P8IP07_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">G-protein coupled receptor GRL101-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116303214</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568572.1">
        <property type="nucleotide sequence ID" value="XM_031712712.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116303214"/>
    <dbReference type="InParanoid" id="A0A6P8IP07"/>
    <dbReference type="OrthoDB" id="5984578at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="826"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="15">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="14">
        <location>
            <begin position="169"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="576"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="18">
        <location>
            <position position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031568572.1"/>
        </source>
    </evidence>
    <sequence length="956" mass="108619" checksum="30AE5AD7F717E028" modified="2020-12-02" version="1">MSYECGTETGDLLRWNDFLNIPLKSSDIQIYKSTCRGKEGSVQSVISPLLPETSSLATIESPRYERSSSSSLRCLKFKYKIWGSGARSLKIYQELDDNEHTKRPIWMVKDXEDSRWRDGQVSVVAVSVYKLVIEGEMTNRPGLLSIGALYTSESTSECVLNPLSAREACNEILTDGKGYIMSPFYPDFHANDENCSWIIKARKGHVIRLEFKAFDLELSPWCLGDHVEVYDGNVALSSSRIGRYCGRRYPQIIQSQSNMLKIVFQSSKSGEGQGFKIYYQMIKGANGDSCIQDCPSSCNCRRLADGGIIMTSHKLQSIPKRLPKKTNAILFGGNKIYQVESNAFIKQSYLSLIDLSYNRIFLIGEMSLVNLHSLKTLRLNRNFIKEVQKNMFSGVGGLEVIDXGQNLISSIEMDTFSGFPALRALSLRSNKIKELHKLTFQNNTNLRYLYLQDNVIKKIPYGLFHQQKYLNVLFLHKNKIERIDKSSFEGLGKLRKLTLRNNSINEQTVSKDVFNDLRDLEYLSTDSFIICCYATNSISNIQCESPGNEFSSCNDMLKSIYVQICMWIEGVFAALGNLVVIIWWTFLFTRQRKSRRKINRVQSLLFCHLAFADLLMGVYLLFIGTYNEIWKGEYFLHDVEWRAGVKCKIAGVIATLSSEVSVMLLAAITADRMNTILFKFSARRTSFKLAHVLCLFIWVIGFIMSFTPLLVPSYFNDKISGFSFYGRSTVCLPLQLSTDRPAGWEYSVAVFIGFNGAVFFFILVGYIAIFDKVRKSGRKVRKSSNNAESSLGKRVFFVILTDFCCWMPIMVLGVLSLMGKFNDPSVYIWVGVFVLPINSAINPVLYTFSSSQTINNIRSLRRKWLKDKGSIRLDGKHLFRKRKSEQSSSAVTTALTLLKTNDEPYGDEGKINESDKASSSAERQMLVIAERQLLVKVDDEEKKSIMRLLLMTRSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP35</accession>
    <name>A0A6P8IP35_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116303406</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568796.1">
        <property type="nucleotide sequence ID" value="XM_031712936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP35"/>
    <dbReference type="GeneID" id="116303406"/>
    <dbReference type="KEGG" id="aten:116303406"/>
    <dbReference type="InParanoid" id="A0A6P8IP35"/>
    <dbReference type="OrthoDB" id="6017582at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031568796.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13515" checksum="4EF6E5B7F363B8DB" modified="2020-12-02" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNMSRRKESYTIYIYKVMKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKKSTITSREIQTAIRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRP6</accession>
    <name>A0A6P8IRP6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116304121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569644.1">
        <property type="nucleotide sequence ID" value="XM_031713784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRP6"/>
    <dbReference type="GeneID" id="116304121"/>
    <dbReference type="KEGG" id="aten:116304121"/>
    <dbReference type="InParanoid" id="A0A6P8IRP6"/>
    <dbReference type="OrthoDB" id="5987645at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027561000" evidence="3">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569644.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17503" checksum="89098BBF0D6CACFE" modified="2020-12-02" version="1">MMKFLIAILFFAFSYWNEVSSITQFNTHEGCNASFVCYHSFGASVNWTSSRGPLKQGPKLVIENASYHSVLYLISVTPAENGNISCQRNQLEALHFSLSVQGKCKDLFNTVTCKGTIDGGDDCTSSWMVTNCRKSCGLCPKFNCTESERPTGKVITRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISP8</accession>
    <name>A0A6P8ISP8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303785</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569248.1">
        <property type="nucleotide sequence ID" value="XM_031713388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303785"/>
    <dbReference type="KEGG" id="aten:116303785"/>
    <dbReference type="InParanoid" id="A0A6P8ISP8"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF11">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569248.1"/>
        </source>
    </evidence>
    <sequence length="896" mass="100368" checksum="25ADAB9219861BCF" modified="2020-12-02" version="1">MKASESTASHETREDEEETVLRDQMESKTKQEGSQEVDCENNCLSGIKWPTGQQAKNQGKKRGIINGFRKIKTGIVTHGGRTSKLPARFMETDSENESIGSKKRVQSRKDEQETSGERSSTCSTSKRKICKNGRTEPLEKKAGTIGKRKRKSKLYSEDDIDVDMLENGVLNVNSSYPSTNTATTETLSRSLKRNLCISHSETESSSDETLHRKRGRPPKTAVKIPNIARGKASESFVSISPHGDCVVSAPNASLTSPNVKPKKKKRKLLXGLRSASVFQGISSDDSSSDCSSPKKRGRPPKTKHSALSASETKLHEFGSKNGVRKPWVRPVLKSLHKRALFRSHEEHLDSLLDSSVKNMTKVKAKLAKMNGFSVSRECTNGELIKRKRGRPPKIDSDKKSKLARDVFSFTDEEDLDSSSFNGHLKKLKKLKKLDKNKLGKRPLAASKVNKTEKLLANKLKKKAIKKAKQTLAASDKESNVGSESMDKNSIESMQFRRRQRNKIDRVLGMRLNTVGQYEYLVQWKDGTSCWTSSDQAADYELDLKSFLGHEYQEFCSINRLVFKAYFHDNLDKLHVPESEAEDYHTSDDETGHYVNDYDDDDDEIFSDADDIFDNCIETVKEDPKPKKRGRKKQDNDKEFLCKEVSVQKLPDCVHITVRRSSGKQMRVNLRIIDSLTLALEEAAVDKAETVVISGLGDDIFCGVDLDTIVTIPLEGEVKNYRKDVDKIRYLIQTIQYFPKPVIATINKPAEGLGAQLVALCDMVCDKSALGDPVNLALAKANGTIPYCFPRLMGHATVSEHVLMGEPLSSPVTDWRDSLSEIFKTTRFTSELLTSVEAMTQLPPCLQGPTRLGERIGNCSSEEEQRLSKEVDVEKNKVQDSLKELMAFWENVTTKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVA3</accession>
    <name>A0A6P8IVA3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC116305188</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="RTK"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
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            <end position="559"/>
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        <location>
            <begin position="280"/>
            <end position="287"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVZ4</accession>
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        </submittedName>
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        <scope>IDENTIFICATION</scope>
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            <end position="99"/>
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    <sequence length="230" mass="25468" checksum="B7E8783D1A97DED7" modified="2020-12-02" version="1">MPRKKVNRKKRKDHDDTESESGKLSETQEVAKRLSRTRLGKENASRPHHVNLKKTKKGPLDPYDADSEVESDINIQTDTDRSPMTPMITDNIPETLPSNPRLTALNPQLSLFHQDHSTPSTITPGRSDDSLYGFGAVLNSPLPFSPVSATPSGLPSSPSGSVFSMTSSMSTTISPGKRKLNLRVFDMPIEKPSKKAKKKKTKLGKEIPQNEVSQVLGDFEEVEMFDLIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXW8</accession>
    <name>A0A6P8IXW8_ACTTE</name>
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            <fullName evidence="11">Tricalbin-3-like</fullName>
        </submittedName>
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        <name evidence="11" type="primary">LOC116306078</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        </source>
    </reference>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="9">
        <location>
            <begin position="86"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="442"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="631"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031571972.1"/>
        </source>
    </evidence>
    <sequence length="998" mass="112771" checksum="F0B81EC585C7F244" modified="2020-12-02" version="1">MATGTAEEVEAKARRQRQDTQFRLSLFVIALISLSWFLGAFGFSYLWCFFLIPLCFTVWYRKNTKIIDERVREAELYVHRKKALRNEESTEWLNFILNRWWNFSETSLCQLIRASLNPVLDYSRPSFIESMELIEFTFGKKTPFLKHVKVFENIDEGDSPNMPATDQNIFKPPDDMQKRQRHLLVLNMDLCLQAPDTKIVINVRLGGKMLGADVDVSLEDVNLSGRAQIVFEMDHMIPFPHMKSVAVTFLEKPEVSFDVCMMRAVQVMDIPMLKDFINALVIDSLTYALVDPGRIEIPLNSVDTEELLNAPRKSTYANGVLTLTVKGGLPQKFTDDQIFTSFKLADQDEINSEKIQGGTTWEGSFSFLTYDLANEHMTIEVRGKRVFGTKYVLAKYKIFLNSLNLEKKKKVDTALEKEGIKGSRLEVTMEYTALDHIDVSSRTNEKEFLEKYNMNDPVNEVAGVLLVVLHSGAQLLSMDADGYSDPYCIITANKEKIKTTAHVQGTVNPVWDSTTEFFVKDITKTNLFFLVYDRDRNWQGLSDDFMGSCSFNLSKEEPAKIKKKLNLKYKVFGKKRSEDSFMDAGTILVSAVFRPVTSVSKSAKEGDLTSIDNGDVIEDINEHAKKHTLKSSMKTKRQIEEMMLIKERGVLVVTLLQAKNLVSMDSNGLSDPFCVVRVNNSKKFKTKVVYESLAPVWNESVSIAMPQGNDKLIVDMFDKDVFQNDFMGSVTFSPEEIEELSKKTIPEWYKLKDVDTGEIQIRLKKCKPGEQVPDVGQDVDEVNQAQGEGEAGDSGFGESSEAQPEEKDALDMALDNIETYANEEGPPVYYSVSGEIIQASDIKGWGEVHIKGRAEIPRKGRKGTIKYEQVQILTTPPLAPEGGLVKWNHIFQTSGGQSISNEAVLVFELRDAKKKTQGISKMTIKEFFKGHHLKKTKSSSGTEEKCSVTKWLNFEYDGMPAGSLQLMLSYSDVPDAPIAPTKFKRKSLLKRISSNPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZN4</accession>
    <name>A0A6P8IZN4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572637.1">
        <property type="nucleotide sequence ID" value="XM_031716777.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IZN4">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="GeneID" id="116306691"/>
    <dbReference type="KEGG" id="aten:116306691"/>
    <dbReference type="InParanoid" id="A0A6P8IZN4"/>
    <dbReference type="OrthoDB" id="5986312at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="494"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572637.1"/>
        </source>
    </evidence>
    <sequence length="1357" mass="155315" checksum="B931F05813BA9B9C" modified="2020-12-02" version="1">MNKEISTSSSTSTQATVVMQPANIQPPTPLSFEGNLAENWKHFLQVWQNYSIITSLDKQPEAYRVALFLHCIGQDAIKIYNGFSFQDADDKTKLDKILEQFQQYAIGQVNETFERFRFNSRNQGEAESIDAYVIDLKNMAKTCNFGALHDSLIRDRIVFGIWCKKTRQKLLQERQLTLEKCIDICRSSETANTRMKAIASGHSEEVKRVQSAKHSQKHTYERKQRNDWNARSKNSKRACIYCGKQHERSRECCPAWSKQCQNCGIKNHFAIVCRQKQNTNSVQDQTDSEDEEFVTSIYMEEELVAQISEPMYAKEIYAEMLIDGEKIQFQIDCGASVNILPRKYVRSQEIRPTNKTLKMWNGTQVRPIGITRASLRNPKNRKRYSVEFIVVDEGFTPLLGARAIQQMKIITVNHEHFNTTAAPIRDNQKISQVNTAEAIVKEYSDVFNRKLGTLPGLVHLTTKDDATPVITPTRRVPATLKEKLRDELDKYVNLGVLAPVEEPTPWVSALALATKKSGALRVCIDPRPLNNVLQRETYQLPVLDDVLPELSRARVFSTADLRSGYWHCVLDDESSQLTTFSTPFGRYRWLRLPFGLSASSEIFQKRVNQALEGLSGILDIVDDILIYGVGKDEKEANENHDKNLRALLQRCRDKGIALNPEKLKLRRKEVSFMGHTFTSEGLKVDPGKAKAIKEMKPPTDVEGIQRLNGFVNYLSRFLPQLADVMEPIRRLTRKEAEWQWGKEQEDAFTQVKELVSQAPILGYYDPTLPLSIQCDASQKGLGAALLQNGRPIAYASRALTTTEQRYAQIEKEMLAIVFSLEKFNQYTFGRPVIVYSDHKPLESIWKKPLAAAPRRLQGMMMRLQKYTVTLIYERGKNMYIADMLSRAPLSTEGRLEDREFEHVNMASYLPIAEDRLAEIRKETQEDPALQKLKTVIMQGWPDNKEGLPIEVRPFFNTRDEFTVQDGLIFRGQRVVIPVKLRQMIKTKLHASPMGIEACLRRARECVYWPGFSAEIKQMIESCXTCRMFETSQQREPLMSHEVATRPWEKVGXDLFEIKGREYLIRVDYFSNFWEVDSLPSDXKSKTIITKLKGHFARYGIPDQVVTDNGPQFASREFRQFANSYEFEHTPTSPYNSRANGKAESAVKTAKRLIEKTTKAGTDTFLAILDHRNTPTQGMESSPAQRLMSRRTKTLLQTTQEMLKPRTTVPEKEVTSMIRRQERQAQYYNRSTKELEPLEEGDVVRMKPLIAGGKVWKKAMVKARLDQRSYTVETEDGAEYRRNREQIKKTKEPAQLPETPKTTTLPAVPELPVTPSKPELPGTPRAQETPDIGVPDATPVRPRRAAKPPAWMKDFVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J090</accession>
    <name>A0A6P8J090_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571603.1">
        <property type="nucleotide sequence ID" value="XM_031715743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J090"/>
    <dbReference type="GeneID" id="116305762"/>
    <dbReference type="KEGG" id="aten:116305762"/>
    <dbReference type="InParanoid" id="A0A6P8J090"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028279887" evidence="6">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571603.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27549" checksum="EAE8058DA6BC103F" modified="2020-12-02" version="1">MKRALYFLFVAFRLLYCEGSIRLSGGKSPNEGRVEILYNGTWGTVCDDSWDLNDANVVCRSLGLPNAASSLCCAAFGKGSGPILLDNVHCQGHEESLFHCQHNGWRSHNCGHGEDAGVVCGKPKIYTVRTNNLSGVIESPGYPQYMRQVNYQWTFSNSVANAQVAVYFDNIDLRRYHGGMSKITVVDSRNTSFLSVQNQRHHPVGFLITNPPLMISFYSSYQSRIGHSGNGIRMRYFVFSGSDKQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0G6</accession>
    <name>A0A6P8J0G6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beclin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572939.1">
        <property type="nucleotide sequence ID" value="XM_031717079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0G6"/>
    <dbReference type="FunCoup" id="A0A6P8J0G6">
        <property type="interactions" value="2786"/>
    </dbReference>
    <dbReference type="GeneID" id="116306937"/>
    <dbReference type="KEGG" id="aten:116306937"/>
    <dbReference type="InParanoid" id="A0A6P8J0G6"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000001">
        <property type="entry name" value="beclin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="6">
        <location>
            <begin position="135"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="5">
        <location>
            <begin position="264"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572939.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51824" checksum="8CA4FF25647350F7" modified="2020-12-02" version="1">MAAKQEIFKGTTYVQFVCQRCYRPLKIDPNLSSLDSDTLAELTAPLSPLPSKKEGSDNEALLPQDQIINEPQEEGSEDMVIRREILPERMQSVEGNGFTLIGDTQVIQSDSLSHKLKVATKLFDVMSEQSDIDHPLCEECTDTLLDQLDKQLKTTEEEFSSYKEFLHKLNEQQLAGDESLSKELEELQKEEADLIAQLEKVEEERKKVSEALENEKQTSRKLDDAEKAFYIEYCEYQRELLEFEDEQQSVENQMRYAQAQLDKLRKTNVFNSTFHIWHKGHFGTINNFRLGRLPSVPVEWSEINAAWGQTVLLLHSLARKMNLTFERYRLVPFGNHSYLESLSDKSRELPLYGSGGFRFLWDTKFDQAMVAFLDCLQQFKEAVEKVDKRFCLPYRMEKGKIYDSSGSGGAFSIKIQFNSEEQWTKALKFMLTNLKWGLAWVSSQFTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0P2</accession>
    <name>A0A6P8J0P2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307062 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573062.1">
        <property type="nucleotide sequence ID" value="XM_031717202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0P2"/>
    <dbReference type="GeneID" id="116307062"/>
    <dbReference type="KEGG" id="aten:116307062"/>
    <dbReference type="InParanoid" id="A0A6P8J0P2"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573062.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14713" checksum="C5D3E2CD3CC25174" modified="2020-12-02" version="1">MSNGHPNKEDPQNTVSNHGKVEGLDKHGSVFHPSAGPVFKVLEAPEYAEVNNPKEEVKNRPYFDSAMYNKKVEKAQKPNSQKEPLYNVLEDPGSLNEPLEGRQAPCYQVLEGPFPEGAPLYDVIAQPPSSDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0Q6</accession>
    <name>A0A6P8J0Q6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307075 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573077.1">
        <property type="nucleotide sequence ID" value="XM_031717217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307075"/>
    <dbReference type="KEGG" id="aten:116307075"/>
    <dbReference type="InParanoid" id="A0A6P8J0Q6"/>
    <dbReference type="OrthoDB" id="10310260at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028133072" evidence="2">
        <location>
            <begin position="17"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573077.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="61793" checksum="EB76B7AC14C78CA1" modified="2020-12-02" version="1">MCRSMILLVFVFSSNAQEYFNVTRQPSTQSDDFSDVFQIPPSLCGKGKGATECYQMGGRXIGDCQCTCDMKAPNEGNNKSNVIYKSTFLFNDGEWQCVNNSLLRKQAGCLRLTQELYDPISTLSRTSSNSTEKLVSLYVPSNSPCVLERLLADNTSYLDCEGRWKSIKGSRFNHTQYGVELIPKSFRRLEPRLDGLIIRLGVKCINRSSVSCLLLKLDGHQICPKPTIAKPTLITVFTSTLSSCGSKCKTLPTPPSQLHMAIIMVLLGVVILVLIVIASVLMNKARLNTRRKRSMRQLFVTNMTYLAENNEHGQNRDDVVEIDQSYDEDGYLCPIDNNAPRDKRYEPKELYIKENNEHGQNRDDVMEVDQSCHEDGYLCPIDNNAPREKRYEPKELYIKEMDGNAERVYIEQPGSSMAEPYEITNLYRLHDSLSEIKPSAVKLTCALQSPLSGGPSECNRHKPNIIKPDQNNAEHFNLRNNHRSKVESIYRVLEDPRAFGISDEVGQLIIENVPQDQSYQELTFDGQRFNVYQSLCIANQKGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J182</accession>
    <name>A0A6P8J182_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GPI transamidase component PIG-S-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116307226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573244.1">
        <property type="nucleotide sequence ID" value="XM_031717384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J182"/>
    <dbReference type="FunCoup" id="A0A6P8J182">
        <property type="interactions" value="1577"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116307226"/>
    <dbReference type="InParanoid" id="A0A6P8J182"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031573244.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61912" checksum="2E8D14C47D8BF509" modified="2020-12-02" version="1">MIGFIFIIIGLPLWWNTTKVYRASLPYKDIEKLAELKLDYLVNIKILIPKEESLLNLKSFDNSLRDQLNSLIAEFAVNPKFEINTRFLSEAENSLLKEKSQRNAALKDLDFALQKLWYGEKSSNGNYIFIFLPSGIFEQMKTTHIGKFLHTIIPYKKEIASELKNIVTVIKNVYINVETISRAFNTASQRNLKTNNMENIRAQKSVSGYQISFTLLNSDPDSVIPWWNIEEAVQKYLNPFLAKVPHLNTSIDSQVLHYSTVQLNPTRDGQAFYLDYKDLPHLINPIEAKLGSYVSLNSNLNFIVYVPSQDQTPLYVRNKDGDVAESNAFLSPQWGGFVIYNINRTNLENNHVELEMRSVMSTFISQLKLLLGGQPIDQPEQSILGEYSSTEITEWEELSLWRTKTMEFLSTSTITLTSLARLLEQISNMVIGDQIQKQIQQALLSIEKSKDALEQGRVTTAYLEAKTALTSSENAFFDPSILALLYFPDDQKYAIYIPLFLPISIPIILSLFEGIKWLKGSKDKSKTDEREKKPIEEKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1E9</accession>
    <name>A0A6P8J1E9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytosolic non-specific dipeptidase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116307316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573362.1">
        <property type="nucleotide sequence ID" value="XM_031717502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1E9"/>
    <dbReference type="FunCoup" id="A0A6P8J1E9">
        <property type="interactions" value="1489"/>
    </dbReference>
    <dbReference type="GeneID" id="116307316"/>
    <dbReference type="KEGG" id="aten:116307316"/>
    <dbReference type="InParanoid" id="A0A6P8J1E9"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000008">
        <property type="entry name" value="Cytosolic non-specific dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000014">
        <property type="entry name" value="Cytosolic non-specific dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="12">
        <location>
            <begin position="210"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031573362.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52657" checksum="C44CB4FC8DCBBD7C" modified="2020-12-02" version="1">MASSNIETVFSYLVKNEELYIQRLADAVAIKSVSAWPETRGEIEKMVNHVADELKKLGATVELADIGQQTLPDGSKLPLPPVILGSLGDDPAKKTVCIYGHLDVQPALQEDGWDTDPFVLKEIDGKLYGRGSTDDKGPVLCWLHVIEAYKENGIDLPINIKFCFEGMEESGSEGLDELIAERKDSFFKSIDYVCISDNYWLGKEKPCVTYGLRGICYFFVEVACATKDLHSGVFGGSVHEAMTDLVSLLDTLVDVKGNILVPGVNDSVAPVTEEEKKSYDPIDFDLEEYRKDIGHNRLLHENKPDLLMHRWRYPSLSIHGIEGAFYEPGSKTVIPRKVIGKFSIRLVPDQKPAEIEKLVIDHLKKKHAESGSPNDMKVSMGHGGEPWMSDFNHPHYQAGRNAMKTVFGVEPDLTREGGSIPVTLSLQEATGKNVMLLPVGSCDDGAHSQNEKINRSNYINGHKVIAAYFEELAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2B8</accession>
    <name>A0A6P8J2B8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116307925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116307925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031574111.1">
        <property type="nucleotide sequence ID" value="XM_031718251.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116307925"/>
    <dbReference type="InParanoid" id="A0A6P8J2B8"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15729">
        <property type="entry name" value="FYVE_endofin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022557">
        <property type="entry name" value="SARA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319:SF3">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11979">
        <property type="entry name" value="SARA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="867"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="931"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="938"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="963"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="8">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031574111.1"/>
        </source>
    </evidence>
    <sequence length="1658" mass="182800" checksum="ADF72291AC61C775" modified="2020-12-02" version="1">MASSTDSHSNSHAKEGALQSMPQDIHEVXLEIAQAMEGKSKEECQALLHALQSSXTQTPPEKQTTDIAKDKNAKLIPDEAEHKGERLESLNKVNDVPSLEDSGTXSVSHFDGQDQSVHEDVKSGTKENNVATEGQENNHEDVNGAGKEEESKDEKDNEKNGGTAQGHGLSNEIPNIQNQIQGVSTEESKRKADKRCLEKADNNQIPYMKSIIKDEKKISPKNSLTVEYRSASVSDENINKLEPSGVRTGNKHDEVVESSDDDMAPSTPASGGRTSGSDLSESPNEKQADLASVRDSFSHVESKRPDPSKAPLTITGTSYSQPQVPDSLNQTSLNSTFERTPLTSNLHNRMQEKSPPTTDNYCSPTIKDPGVSKTFTRARHLPASTQEYGSLDIGQFYSLSGAQHPKPKISREPMKKRDSELPGSEELHTSTGIPAGFQYPGLNSAFHSTTPASSSAVRTGVQISMSTTTSSSTSNTSTVMVKPQNSLISTINTLPSMPLYYQPHIVMQEQLPVLVLRPVLAQDPASSSPQIPSSDCKAELTLESLPLVFPLGSANEVKGNIDDLQVQPKLVSDDEDADLFNKHESFANGAELVSGYASSVTESEMDEAPLRKPPPRSYRDSARPTKPHTMYQQSHGRSSNKPFDWQFPSSNPFTDKYDNTPTTDISDLKLSSSKVPMTSSKEDQFLYYKQGARSKITNKTNPFAPEIPPRTDIEELSRNNFRSIPKSMLATTESKSRTSVVQPQPKGEASNTHRRRSSNDSMITLIETECEKEPSLDITEAVAXQGNNSDNSYQSQIFEPSSRSFFEENXSFSQHDSLAAPATYPTAQISPSGSIPRSQSASTMTQEEPRRTKPKLPGHAAPLWIPDDQINKCCSCHQKFTLIRRKHHCRGCGKIFCSTCCSQLARLSYLQYRIGRVCVFCTNIIKDAMRAKKAKGSPNVSENTKQASPKITGNQITGGRTQSSPSPYTPLSLSNSNVPKISGTPTQPXNSQGHTNLNQSGGSTSQPNPQPQPHVFVPSTPNYQPDCITYTDPVTGQLVKAPIVYQPQSTFPGQTVIPGQTVVPGQTVVPGQTVGLPVNTISQNQMQGDXIQSGXPPSQHLKSQNVSAESSIPEKAEVKDFSLPLRPAGRIVSWKNGKVSNRLMFQDRRKALAKDLKELPNGVTIQVADEFQVTVKKIKVHRPPLTPYLAWCFCSNGFNTLGHTEIVILLELKQKEDLFPEEMLRIYKVILDLVKLGNSFNHGNFIAFNSPFLGSTENAGFLFADDSFTKKLPAIYEDKTKVLYGILVKRPELEIIKHMPMRFLLRLGQETKNFPFPVVNSRDRAVVYDGIDAEDKFYHTSCAMNTYLKNIVPEALIPGLVVVKEDGKIVLQISLASQTAIVSLFDRLVVKAHQTATVPLASDLSHDIHEYKVFHQSIVTKEVSFAKSISLFRNPGVRRQSHPSVTGLGFLILHLGASSNAMMSHGGEVVDDGAVVYLSQFHTQKLRQSLYEHSNCYFYLGDRFEVVHFELRWLQNPQQPQPAQTRVLKTTHEPSNKEEFPGTATIDVRHSGHTGEVKKLASAGVGDALFFIRSIENRIKMVCMEPLMMQANKMKEGEAKKLILRVSLKEGIKKWSIGPSNQPMNLIRSLQMALHAVTLTELHNARLELTFDVTIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2V7</accession>
    <name>A0A6P8J2V7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308069</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574291.1">
        <property type="nucleotide sequence ID" value="XM_031718431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2V7"/>
    <dbReference type="GeneID" id="116308069"/>
    <dbReference type="KEGG" id="aten:116308069"/>
    <dbReference type="InParanoid" id="A0A6P8J2V7"/>
    <dbReference type="OrthoDB" id="5976668at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027967159" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574291.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16014" checksum="0590319E05422D06" modified="2020-12-02" version="1">MKSQALLVIILVQIYYLQALQHTKAFQDLEAFNKRSSETETRFRRSGACAEICIHRCLPSCNLACCVERPIGVNRHMINKMEVAAAKKIAETGSKKSILGSKENQLYVSKEEMEKGTTCDKKCLIHCDPSCKFKCCIRVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2W7</accession>
    <name>A0A6P8J2W7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116307763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573929.1">
        <property type="nucleotide sequence ID" value="XM_031718069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307763"/>
    <dbReference type="KEGG" id="aten:116307763"/>
    <dbReference type="InParanoid" id="A0A6P8J2W7"/>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000001">
        <property type="entry name" value="neuralized-like protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF15">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="274"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573929.1"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113741" checksum="C5C67345062A2755" modified="2020-12-02" version="1">MGAEHSLELRRRQGLPPELADALLTSALLEALQEAASESDGSSEMLEHAWDPRDCSPPFVVLPDRLTARRRPSILTTDCIRGKKGYRGGQHVWEIKWENEERGTFAIVGVATPKAPLQSLGYXPLIGSNSESWGWDIVSKTLWHCGKRGSYPAVRTGFQVPDTFFVILDMDQRTLSFSTSDLHLGVAFTDLPKQLDRPMCPVVNAIFGNCDIRMRYMGKGESIISNLRRPIAFHRATSETPSEAPKKASEDSRRKSTGTPGKDSDSSVVEASKRYQFARHKHGENVAVMYAGKKAKRVDPFGSCCDGVVITSEPLKDNELFEVRLDSKIDRWVGSLFIGATTNDSNSFSTFPQIMVDYTQGSNFMWAGDQIVFNKKLTTTVKEDTGKLTTGDRIGVMRKSDNSLHFYLNGKDIGNCFKTIPDVLYGVVDIYGQAEQVTITGGTAETQSSNDDEKSGEQDHIIVMVQMKKAIEMMKLPFNPLLIIKMLYTSVAEPYTNTQDRAVRQRYGDHLSDIGAVPELKKFLERLDRPDLGIESKEGWIGMTIVRSILWNYSDASLKIAKEIGKCGLLGRFVNDLKRIGPSGAFGDEKQKRIIDSAVNILHNCAKATENRQVFRDINAVEILAPFXKCEDSDTVISALLAMSYIIEDNQKHLLDADTKTIAKLRGMLVNAANSPGLRGSVDSSSWSAFEIVSGIANIAVNEKNRANLIEAGVIPPLFDVIKKGEPMDKECSANALWVLANSEPGKKKIRDYPGAMATLNGLSKNSNKSIAAAAERVLLRIKQQPMQQGVPLRGMPRKNCSYKETCRLFIAALDLNDVLFDHKYDKCYCTECHASRNEKLYYTQGKPAKDYAIPIGWARFALKMERTAVIHNCDTDWHVAYHGTSPDSVKSILEDGKLLMPGDETLEGKRLCEVDGHFTDDNKPEGFNTKQIFVSPSIRYSGXEVYAKSKRFEDPQTKKTYKAKVVFQLWIKPDSYKVGQQTVGAENEIDPKFSNQEIEWATARRXAIHLYGVLVHLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J451</accession>
    <name>A0A6P8J451_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC116308192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574437.1">
        <property type="nucleotide sequence ID" value="XM_031718577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J451"/>
    <dbReference type="GeneID" id="116308192"/>
    <dbReference type="KEGG" id="aten:116308192"/>
    <dbReference type="InParanoid" id="A0A6P8J451"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF24">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028320274" evidence="10">
        <location>
            <begin position="22"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="11">
        <location>
            <begin position="171"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574437.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52514" checksum="0CAAEAEA98BF72CB" modified="2020-12-02" version="1">MYVKSLSFVVLILQLLPPVASSPALMTMEEGEEVVFMFNKYANTRILEVTWGISDGNTSNFRLVLIVVRNVTGVQSITSTSKAAYAGRVSFVGDMSKGQAWFKITNLNINDTNKYMAQIRAHGSSNYEDIPAQLTVIKTPVTTEPLKTSTRELTTGVSSSQTSLWPTTSQVPKFSNRSMSINVVKKVVGDFSDPNSVAFKQFSKNFVSEINSVYKNIHIFEKAKVTGLSETIISVKFVVYFKSTRKGDEICGPLKDAVKDNRLGSLKIVPGSLGCSNDPSTSVPKKPSNSASTCTSIIVACVTVNIFLILVVVFLVIYIWRLRLNNEKRAGRRNSSSIQDKNPEAYENIHPMEDTSQAITTKTAQTPNTGKELYETINENRDKNNVAITTIVKHTSGSSVAIQGDAPSLPQHYQELQRKAPNPTSLYEPLKQQGFRNKEELASEDPKTYEQLQQSAPGREYQSLKCYKDTESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J484</accession>
    <name>A0A6P8J484_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116308528</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031574836.1">
        <property type="nucleotide sequence ID" value="XM_031718976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J484"/>
    <dbReference type="GeneID" id="116308528"/>
    <dbReference type="KEGG" id="aten:116308528"/>
    <dbReference type="InParanoid" id="A0A6P8J484"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="14">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031574836.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57605" checksum="A9B3F111BE5C7F27" modified="2020-12-02" version="1">MRERATRFWPYWVEGAKALRKRKPEIEKRAAQRTLLFMGTFSVEPRFFEYAYHGGPLGELVQWTDLICSLYILGHDLDISANTDDLKKRLNVPKLKNCASASRDDDYDQIFTDYNGHKLIAFAVGPNHSQYRCKIRILDSFGTDAEFNFAEYSEPIPGGRSPWANADVNLRQIFTMFPHSPDNSFLGFVVDSPVNDTKVKKVEKKSKKPIGLVYGKEARFWKGHKDYLDTLSKYLEMHATTSGPEGDLKSLPDYVINHGILKGGDLQKLLDQSKVFIGLGFPYEGPAPLEAIAHGNIFLNAKLDPPQNRLNAAFFQLKPTFRALTSQHPYAETFIGEPHVFTVDIKNVSVVENTIKKILKTKVKPYLPLEWTPEGMLERISSFAENMKFCYGYDKIWPPEDELQLILGDEGISCKEACWKKGLLCESLFFNKINTKESFKELRIECDTRDDRGSLVMPAYISAEKSCVLQNHPLLFSCVASKAKHTRLCPCRDFQPQQVALCKKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4H0</accession>
    <name>A0A6P8J4H0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="34">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37" type="primary">LOC116308286</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="37">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 33 34">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 33 34">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="34"/>
    <dbReference type="RefSeq" id="XP_031574534.1">
        <property type="nucleotide sequence ID" value="XM_031718674.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J4H0">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="GeneID" id="116308286"/>
    <dbReference type="KEGG" id="aten:116308286"/>
    <dbReference type="InParanoid" id="A0A6P8J4H0"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 33" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 33 34" id="KW-0274">FAD</keyword>
    <keyword evidence="7 33 34" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 33 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 33 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 33" id="KW-0521">NADP</keyword>
    <keyword evidence="14 33 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 35" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="XP_031574534.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59820" checksum="2CDCB1941851E021" modified="2020-12-02" version="1">MKVAVIGSGXSGLVAMKSCIDENIEPVCFEQEDTIGGLWNFTEEQRHSSVYRSTVINTSKEMMCFSDFPIPKDFAPFMHNTKVMEYFHLYAKHFDLYKYIRYQTKVTDIRKAGDYDDTGNWEVCYVSLIGAEANVVKTEVYNAVMVCIGHHSSPHWPSFQGMDEFNGIKIHSHAYKDFRRFEDKKVLIVGIGDSGSDIAVELSRHASQVYLSTRKGSWVLSKLHESGVPIDHWANRRILQLLPKSFFGILLKAQANKKFDHRCFALEPDHAPLQQHPTLNDDLPNRIINGTIIVKPNIAHFTKSGVVFEDKTAVDLDAVVFCTGYDIGFSFIDKSVIPVDDNDVTLYKYVFPPHLPKWSLAVIGCFQPLGAINPLAELQCRWATRVFKGILKLPSEGNMMNDIKKKKEEMRKRYYTSRRHTIQVDYISYCDELAEQVGCKPSFLNLLLSDPALALRCFVGPCTPPQYRLTGPGVWPGAREAIMNADINIMHSTKTRVVKHEKGDNSSLPLAFTAIVFLVIMIAILLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4U2</accession>
    <name>A0A6P8J4U2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable S-adenosylmethionine-dependent methyltransferase At5g38100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116308731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575071.1">
        <property type="nucleotide sequence ID" value="XM_031719211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4U2"/>
    <dbReference type="GeneID" id="116308731"/>
    <dbReference type="KEGG" id="aten:116308731"/>
    <dbReference type="InParanoid" id="A0A6P8J4U2"/>
    <dbReference type="OrthoDB" id="1890922at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031575071.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22638" checksum="83FA2799CB28EE7F" modified="2020-12-02" version="1">MEEIKFSDPHSHAPYGKDGSGYYSTNVLACYDVNELAINLMLKAARSIPVDSNSSVFTLVDYGAADGGTSMPLVYACVKELRKKYGDELAIHVIYEDQPINDFKSLFMLLQGLIPGPPSFHVDFPNVFVTASGTSFYSQCVPNNSVTIGFSGTAFHWLRDKPCDITDATSYVASTVPEVKQKYREQAEKDWELILMKRAAELMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5S7</accession>
    <name>A0A6P8J5S7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116309066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575466.1">
        <property type="nucleotide sequence ID" value="XM_031719606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5S7"/>
    <dbReference type="FunCoup" id="A0A6P8J5S7">
        <property type="interactions" value="1298"/>
    </dbReference>
    <dbReference type="GeneID" id="116309066"/>
    <dbReference type="KEGG" id="aten:116309066"/>
    <dbReference type="InParanoid" id="A0A6P8J5S7"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031575466.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12619" checksum="56D747044FCD765B" modified="2020-12-02" version="1">MAEEEHGLHDKEKEAYSPFAIMTNNSIIEFCRTSLAAMAGISAGILGLTGLKGFIFYFGASILMSVFICWKAGTQWSKYFISWWDLSTSGILGGIFTYLLFWTFLYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6K7</accession>
    <name>A0A6P8J6K7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SPT2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116309016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575399.1">
        <property type="nucleotide sequence ID" value="XM_031719539.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575400.1">
        <property type="nucleotide sequence ID" value="XM_031719540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6K7"/>
    <dbReference type="GeneID" id="116309016"/>
    <dbReference type="KEGG" id="aten:116309016"/>
    <dbReference type="OrthoDB" id="6259853at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054552">
        <property type="entry name" value="SPT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22878">
        <property type="entry name" value="SPT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPT2 homolog N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031575399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031575400.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51398" checksum="EE9F070EBA62C95D" modified="2020-12-02" version="1">MNFQELMSKASENNISASKQLTKSGHKHKDSAPGVCNSAVKAFLERKEQEQKKKQADEEAAKRARIQARLLQNLKTNEGKKGKNESTPKSSFLNPPYKQGEEEEKSMLAKWKKDDVAAQYQKSGVSSKPSVSGIKSIDITRSAITKNMKAKHSKRISKDKSGKSNDFVVNGKKSETSKVKKEVKTASAPPNFKELLAIAEKNKFGLKRTKRETETVTGENKTEVTKLKRWHNSSGEHELTEMDEKQLPIKNKEKVKEKAVSKAKGKQKESLRKTAVEPDRDSCHKQRSHVNESSKTLKRIRDSETLEKNALNKKPSKPLIHHARPQESKDRMMYEQKNYYPRPTHNYYEEEEDSDLDGFIVDGEDEACAEQTDVSKYIKDIFGYDRRRYAVEDFDDSAMESNYGQIEREEKRSAKIAKLEDEIEILKEQAELKRLRDNLKKSKKTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6L3</accession>
    <name>A0A6P8J6L3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L28, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116309048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575442.1">
        <property type="nucleotide sequence ID" value="XM_031719582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6L3"/>
    <dbReference type="GeneID" id="116309048"/>
    <dbReference type="KEGG" id="aten:116309048"/>
    <dbReference type="InParanoid" id="A0A6P8J6L3"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031575442.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18380" checksum="3E703C2111074032" modified="2020-12-02" version="1">MVQLGLRFILQKAIPKRAHTGIYAGKGIMMGHVETFSGKKTKRSWKPNVQRKKYYSEVLEKTVSYNFTTHAMRCIDKAGGFDNYILNTKDSKLHSRAAIDLKKLMNKVLVCKNEGMEIDEIKVKVFPQPKVSCHQYIPKDYTDSFYFDWRGRKQIVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7G4</accession>
    <name>A0A6P8J7G4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573075.1">
        <property type="nucleotide sequence ID" value="XM_031717215.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307073"/>
    <dbReference type="KEGG" id="aten:116307073"/>
    <dbReference type="InParanoid" id="A0A6P8J7G4"/>
    <dbReference type="OrthoDB" id="10277459at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028081109" evidence="2">
        <location>
            <begin position="18"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573075.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49758" checksum="BB5CDBD7EE91B2A9" modified="2020-12-02" version="1">MRHFMWIFIALLTSTLAEEYIIERQVHLIQGSWXDQPDTFMLPSSMCSGDVSANCTAMGGTRINNTCGCSCNEESKFKEFYKSTFGYYENQWKCFENTKVRSHSGCQTIMNERQATIPLMTLPMVQPTVGHNIPGLTSQCGIIGGKYLECDGKWHQLNTTLIKSRFYIDEHKYFYYSISEPPTPTINGRVIRLEIWCTQPKKMHCVVFKVKGQLKCHVIKPTSPSSSIWTTTNKSIQMTDQFNKTGERTGSHDDNSTMIAGAIAGVIGFVIIVIAVVVVIRRRSKRYHVPKRPNFVENDCYGLGVDVSLRFVVAGERSQNEKEHDSFATNLNREIPRAVSQRLYNIEDREYAVPYKTGTKPQASSDVPICDALKRPKYPKTENSKNETQSVPFYKPFVXEXRHAAVEDNEFQELPEYRVLEGPFSEGASVHAFSEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7J5</accession>
    <name>A0A6P8J7J5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307655</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573793.1">
        <property type="nucleotide sequence ID" value="XM_031717933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J7J5"/>
    <dbReference type="GeneID" id="116307655"/>
    <dbReference type="KEGG" id="aten:116307655"/>
    <dbReference type="InParanoid" id="A0A6P8J7J5"/>
    <dbReference type="OrthoDB" id="5979519at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028139815" evidence="1">
        <location>
            <begin position="30"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573793.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50468" checksum="B9A375563E4003F1" modified="2020-12-02" version="1">MRSSKMARIFKIAFWLSVLILNEVGPANMVRLNAGKYIGESKAHKKGYGTENTDSREVENINENAEGKSGIKVATKFAFKIFKIGAQVIPKMITLASFSNAIFRAIAGCCPDFPEACESHDKIVKLQEEIRKKSMNIDDLQLEAQNLQEWTESSRNKFSLLVAEMARIIDNTDVLVRSISPQVIIAVNNQTVVIKKLVRAKKEIGEKVDLDTVESMYGNAIGSFVDITLPLFQLILPSIPKVVKFAAEKFAVRQAHQLDQILENALKKPSPNTIDAVRARGWFAQTKAKIDTKINSIKLRINAKYSNAVDILSKAGKGLSFLFDALSTGYELYSIIDSVLSCKEKRDTVLKSLKELQTASKQLDEIYDKVKESKMVVQKAWTTMHSQVSSKALIRDLKEIQKILASISDPSSEIEYMSSRIGVYIAKIAQTTHSSSPDDIYQLLDDLTTVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAN2</accession>
    <name>A0A6P8JAN2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein Musashi homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Musashi family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573875.1">
        <property type="nucleotide sequence ID" value="XM_031718015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JAN2"/>
    <dbReference type="FunCoup" id="A0A6P8JAN2">
        <property type="interactions" value="1744"/>
    </dbReference>
    <dbReference type="GeneID" id="116307714"/>
    <dbReference type="KEGG" id="aten:116307714"/>
    <dbReference type="InParanoid" id="A0A6P8JAN2"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12576">
        <property type="entry name" value="RRM1_MSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12323">
        <property type="entry name" value="RRM2_MSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034126">
        <property type="entry name" value="MSI_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031573875.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="42207" checksum="74C131D387ADCF1B" modified="2020-12-02" version="1">MEENSSASSKNDGSNDPGKMFIGGLSWQTTAEALRQYFAKYGELKECVVMRDPVSKRSRGFGFVTFIEPNCVDVVLNSCPHDLDGKKIDPKVAVPKRAPAKMVTSTKKIFVGGLSTNTSEEDMKNYFGKFGTITEVMLMFDKATQRHRGFGFVTFDSESSADDACGNQFHLINNKKVEVKKAQPKEVMYSLQGGRGRARGGMFGRGIFYPLPGYGRTQGFPVPGLSANPFQGYNAAYAAYAAFAAQGRGRGRGRGFITGYPGAIGFPNYVVNQGDQRRPAGGQYYAEYAAIGNSGARGNNPRHEVQQLETIPDYQDYGGGMQALNGYHQGQHGYGPPPTSPVSRAFAAATSPGPVNVGQEMNYMSAAGGSGAGELGFTATSPQPNAYNPGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAT8</accession>
    <name>A0A6P8JAT8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116308531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574838.1">
        <property type="nucleotide sequence ID" value="XM_031718978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JAT8"/>
    <dbReference type="GeneID" id="116308531"/>
    <dbReference type="KEGG" id="aten:116308531"/>
    <dbReference type="InParanoid" id="A0A6P8JAT8"/>
    <dbReference type="OrthoDB" id="10276337at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027590979" evidence="6">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="7">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574838.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="35726" checksum="FE6B87F0B7F23542" modified="2020-12-02" version="1">MNKTSIVLVALVSILKIKVNEASQCVARQSESNVFLYGSLIESFKVDTLSTCTSRCKQNKVCSSINMNLMNMKCDLNYSTKKRLPKNMASQPSMVYMEIRDDNATPGTRQDIPTTSCKKLKADDSLSKSGVYWMKLNEPSSAPFQVFCDMTTDGGGWTLVYSYTFTRYSSFRTPANAVTPIPNWPVNRSPSGSVPQSTKTPLSESSRSAMDFSLWKKIGKEFLIKSNISNWVACVEGTGNFVNWVAGSLTCRVVKAITLPCTTIAPNTLGFGGCGPILKKDDKLQYFFEGRTDLCWPVHDPCGTSPSSSNHKTNVANPGGAVYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCI0</accession>
    <name>A0A6P8JCI0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRO1 domain-containing protein BROX-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BROX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575308.1">
        <property type="nucleotide sequence ID" value="XM_031719448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCI0"/>
    <dbReference type="FunCoup" id="A0A6P8JCI0">
        <property type="interactions" value="1668"/>
    </dbReference>
    <dbReference type="GeneID" id="116308928"/>
    <dbReference type="KEGG" id="aten:116308928"/>
    <dbReference type="InParanoid" id="A0A6P8JCI0"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09243">
        <property type="entry name" value="BRO1_Brox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038898">
        <property type="entry name" value="BROX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23032:SF13">
        <property type="entry name" value="BRO1 DOMAIN-CONTAINING PROTEIN BROX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575308.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="45576" checksum="61D8D2E4694BF7FD" modified="2020-12-02" version="1">MAHWFHRNPIKASAPVSFESIRNIATNPSASKILADLRQSRSRLLSLLTDPANETTSIQNAYEMYFSLLVGLVNDPGGAGDSKLRKLIVFKWTNSICGNTPTCEADSVFELMSMCMNIAMWYTKHAAKVAAKEDISMEEAKEVHSCLRTAGGLFQFVKDSLLPRLGNTSAEKGADVDTRVIEAYRMQCVAEAQEVTVARAVELKHKASLISSLANETASLFTSAGDSLKSVEPSKAGKWRKYLELKASFYLAYARCFQGELLLEAEECGNAIKALQESQKSYEKAETLCKEYASIKGPGTTARPQEHPFFKRIGPLMRTRLEKATRENGFIYFHKIPAEPPELEMKATFGLASPQEFNLPAPFSLWTDAYAGFDVSKAQPPKSTAGAGEDIKPVHEADDKGPVKPAKNSSGCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2K9UYQ3</accession>
    <name>A0A2K9UYQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Globin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11 12 13">Neuroglobin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC116296393</name>
        <name evidence="9" type="ORF">A.tenebrosa_nvec7000121</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Evidence for a large expansion and #subfunctionalisation of globin genes in sea anemones.</title>
            <authorList>
                <person name="Smith H.L."/>
                <person name="Pavasovic A."/>
                <person name="Surm J.M."/>
                <person name="Phillips M.J."/>
                <person name="Prentis P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12 13" key="2">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KY810198">
        <property type="protein sequence ID" value="AUV50077.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560268.1">
        <property type="nucleotide sequence ID" value="XM_031704408.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560269.1">
        <property type="nucleotide sequence ID" value="XM_031704409.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560270.1">
        <property type="nucleotide sequence ID" value="XM_031704410.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560271.1">
        <property type="nucleotide sequence ID" value="XM_031704411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2K9UYQ3"/>
    <dbReference type="GeneID" id="116296393"/>
    <dbReference type="KEGG" id="aten:116296393"/>
    <dbReference type="OrthoDB" id="5976642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01907">
        <property type="entry name" value="WORMGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AUV50077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031560268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031560269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031560270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031560271.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19081" checksum="4633CF708CF226F3" modified="2018-04-25" version="1">MGCGGSKSVKTKNSTTNSGSLEKRQIDLVRESWELVKPDISNHGMTFYTRLFTEHPEMQQLFSFKDVEGIDKLKDDERFQNQARRVMEMVGSAVEGLDDIPALAVVLKTLGSTHVKYNVKEEHYGPVGEALIFALEKGLGDKFTSETREAWLAVYGIVADNMKAGAREAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYP0</accession>
    <name>A0A6P8GYP0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial genome maintenance exonuclease 1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGME1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031548638.1">
        <property type="nucleotide sequence ID" value="XM_031692778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GYP0"/>
    <dbReference type="GeneID" id="116286306"/>
    <dbReference type="KEGG" id="aten:116286306"/>
    <dbReference type="InParanoid" id="A0A6P8GYP0"/>
    <dbReference type="OrthoDB" id="5777131at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008297">
        <property type="term" value="F:single-stranded DNA exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03030">
        <property type="entry name" value="MGME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31340:SF3">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031548638.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50548" checksum="5C02F04C92487064" modified="2020-12-02" version="1">MIQNQLKNTTKPYRCLFDLRNIQKAKVEHLVNARLLHQLHKDYDESTAKSKIPFKNIGKPVNNQRYLQCIHKPLSINHQMSDSVGGNRMYLERYPSVTTILSNTKPPNEFFGLMNWRKSNIERFGKEKFGLMQKDTTIKGTTFHQDMKEYFAAESSNERHHKLHTSGFIKSVCNVLPNISNPLAVESSVVHSSLGYAGTIDLVAEYMGILSVIDWKTSQKKKVNLTQCHSYPIQISAYAGAINFDLDYPFQILNSVLVIAYENGDPADVHIMNEQLCEEYWEKWLIRLHQYKAMKSRDSVEPKRTGWAIIEDQYVSTSLISDENGPQERLSEGAQMIENGQNLKSFVRRQPVFDVKQNRGKSLNEIGKTVKDEEIVATWRNLTGLTESIFGRVLISKGLLMTHYITSIFKVSMKKIFNSMDLIPKKGNQFHEKKIGKHGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H090</accession>
    <name>A0A6P8H090_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116287313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549839.1">
        <property type="nucleotide sequence ID" value="XM_031693979.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H090">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="GeneID" id="116287313"/>
    <dbReference type="KEGG" id="aten:116287313"/>
    <dbReference type="InParanoid" id="A0A6P8H090"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
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</entry>
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    <accession>A0A6P8H1F6</accession>
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        <submittedName>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031549701.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48400" checksum="7A6DD9F5F3916FD5" modified="2020-12-02" version="1">MGIRCLSFTNKKNPFTNDPDVIGERRCISSTSPPAAAAISWVTEALLTPVLLAHSPGNNTILKVQTSDVPDVPNELCSVATQTEDYGCVNQCTSMYVDNERQTENRDSESNEIREEVNEGDTIDANEQNTLNNTDVDENLDEVSEDYEMDESLGTIVTKMXGRKELVPNVQTKHKRNTKTYDCSYCSRTFKWKSVLDTHLRTHTGEKAYQCSHCQKAFALKTNLGLHLRTHTGEKPYECSCCDKAFISKTELKIHLRTHTGEKPYDCSCCDKAFITKSELNIHLRKHTGEKPYECSFCDKAFTKKMTLKIHLRRHTGEKPYECSFCDKAFALKTNLGIHLRRHTGEKPXECSYCKKALAKKCTIDVHLRTHTGVKPNNCSFYQKEFAKNNNLDHHLRKNTGEKPYECWYCIKAYTKKTSMNIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4P6</accession>
    <name>A0A6P8H4P6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM133-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM133 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551324.1">
        <property type="nucleotide sequence ID" value="XM_031695464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4P6"/>
    <dbReference type="GeneID" id="116288639"/>
    <dbReference type="KEGG" id="aten:116288639"/>
    <dbReference type="InParanoid" id="A0A6P8H4P6"/>
    <dbReference type="OrthoDB" id="10065679at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026766">
        <property type="entry name" value="Fam133"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31911:SF1">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 133 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31911">
        <property type="entry name" value="PROTEIN FAM133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551324.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24845" checksum="37016F33DAF20917" modified="2020-12-02" version="1">MGKRDKRVAYVNPLAARSYAGPSGPTIRDYLNRPRPTWEEFQETLNKSKSGSSTLAAYEEELNQKFKEELRKNRDAINSKTKKLSKQKKKDKKRKKKKRKRLHSSSSSSSLDTDSEREKTYKRKKKKRKELKSKKSKDRSSSEELSSSSSSTKDDSKDKPDEYVKRKKERSKKRKRSRHKDTRTSDEDDESYVKRKKPKRKRKDSSDSDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H516</accession>
    <name>A0A6P8H516_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein six1a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550618.1">
        <property type="nucleotide sequence ID" value="XM_031694758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H516"/>
    <dbReference type="GeneID" id="116288046"/>
    <dbReference type="KEGG" id="aten:116288046"/>
    <dbReference type="InParanoid" id="A0A6P8H516"/>
    <dbReference type="OrthoDB" id="5957328at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550618.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29637" checksum="A1CBBC0A67212559" modified="2020-12-02" version="1">GNNVNEGQELIDLWDQAHYCIAEKEKNRTLTSLEKFRIRQKNLPPESICPLGKRRKISHSKKAVQILNSWFEDNSHYPYPSRAIVEDLCKRCGLSDKQIKTWFANARRKLKDPGLKQVERNIDSSYIDALDSHSTPKDLQKIHHPDFSNTTSQPRCLEDQVLRNVMSSRGNFEAPVGPFFHELAEPRVNIIPPLKLPHGMNSGRPSVILSWFREGLYSSPPSISPRYFHDNSYNLNTPLQGENLCPHWAIPGPGCTKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6J4</accession>
    <name>A0A6P8H6J4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neuronal growth regulator 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550978.1">
        <property type="nucleotide sequence ID" value="XM_031695118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6J4"/>
    <dbReference type="FunCoup" id="A0A6P8H6J4">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="GeneID" id="116288349"/>
    <dbReference type="KEGG" id="aten:116288349"/>
    <dbReference type="InParanoid" id="A0A6P8H6J4"/>
    <dbReference type="OrthoDB" id="5986705at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="61"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550978.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25503" checksum="52B317C6C8217227" modified="2020-12-02" version="1">MPNVTWQKVQGDVINQSVGNVTIDITNITRYESGEYECCAINNLNKPPFCKSILVTVQYEPQIDVFQSNDTVSSYNGGKIRIYCLAHGVPSPLFTWYDPHNRSIATGSHTVTGVSVLELVTINAGSYGLYKCKAENLLGYDEHIINVTQTDHPPSLKPSRNHHGITTSSSQTTTGHESRTQPGERSCSTLFIQGRTFATVHFIITSISIGVNIIMALLVCYIFKRTGFKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7G6</accession>
    <name>A0A6P8H7G6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitelline membrane outer layer protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552354.1">
        <property type="nucleotide sequence ID" value="XM_031696494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7G6"/>
    <dbReference type="FunCoup" id="A0A6P8H7G6">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="GeneID" id="116289544"/>
    <dbReference type="KEGG" id="aten:116289544"/>
    <dbReference type="InParanoid" id="A0A6P8H7G6"/>
    <dbReference type="OrthoDB" id="6344411at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.20">
        <property type="entry name" value="Vitelline membrane outer layer protein I (VOMI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005515">
        <property type="entry name" value="VOMI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036706">
        <property type="entry name" value="VOMI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841:SF0">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER 1 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18841">
        <property type="entry name" value="VITELLINE MEMBRANE OUTER LAYER PROTEIN I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03762">
        <property type="entry name" value="VOMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51092">
        <property type="entry name" value="Vitelline membrane outer protein-I (VMO-I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027650531" evidence="1">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552354.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23544" checksum="485938E95036F0DC" modified="2020-12-02" version="1">MTMLFYALVLCLASCSVDARRRDYAGSIQPYTYTSWGSWGHEDWCPRGTYGYGFSLKVETYQGSGDDTSLNAIKLLCRKPCGGYPNSVTSRKGGWGRWSYTSHCPEYYFLHSAQARSESKQGSGDNTAANNYNFRCQNFKKRKDHYSLSGGGSGWGSWTGRRDCPYASYICGIKTQVERYQGSGDDTALNDAIFYCCYFIAEFQKSCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7S7</accession>
    <name>A0A6P8H7S7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116286408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116286408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548787.1">
        <property type="nucleotide sequence ID" value="XM_031692927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7S7"/>
    <dbReference type="GeneID" id="116286408"/>
    <dbReference type="KEGG" id="aten:116286408"/>
    <dbReference type="InParanoid" id="A0A6P8H7S7"/>
    <dbReference type="OrthoDB" id="5945029at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF42">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027640006" evidence="3">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031548787.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43805" checksum="CD8702FBA0CD56CE" modified="2020-12-02" version="1">MFAHVIITLLSCVTHVTSEFQCQGTCYSGSFPKNNQVIKGKHLRGYSYKNITTDVPHTCFSSCINDCRCKAFQMKDVRCELLDEDKTSKAADFVDETGYVYYDLQQTLYKGNPSSFVIPNDCSNGCCQNQPCLNGGTCKEKCQHPRTKFNCKCTTQYHGRVCEKKVASCWDILKSAPEGPRPDKGVYNITLTNTNITVPVYCLFDQKLVWTLIESFSLENLQLYVEKAFHQDFSRNVDAPDKWKDYRLSLDMMKYIRSKAVMFRATCEYPNRPSNHLLTDSLLGYLSDYDLINGGDVEGKCFKFAYINIRGQEFFNITTAVWHKLNTHQIHLDCHAAPCGNLKLIDSVAEDDCFGKYNPIRRELSKCTATQQSTTQWWLGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H891</accession>
    <name>A0A6P8H891_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116286319</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116286319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548655.1">
        <property type="nucleotide sequence ID" value="XM_031692795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H891"/>
    <dbReference type="GeneID" id="116286319"/>
    <dbReference type="KEGG" id="aten:116286319"/>
    <dbReference type="InParanoid" id="A0A6P8H891"/>
    <dbReference type="OrthoDB" id="5972834at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028215038" evidence="6">
        <location>
            <begin position="34"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="386"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031548655.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59800" checksum="89ABF118B00D4CD4" modified="2020-12-02" version="1">MCVRQLRRNFRLFFMSLLPIVLILLSGFQNVLALNKKESIKYFLEHFESSRSTYLPANKTKVRTLIQEKLKEQGFKTSFQAVPVGQDSYNVIGRIDGSFVNTAEDRIFIVGAHYDTYQDSPGVDDNGSGLAALLQVARQFNDPDQDCQRNYTLILVAFDQKECQSCNNEDRFQCICSYGSATFIKDLTGYLGVSNEKGKIEGAVILDGIMNFDSSYDSQNFTELENHVDDSVRSTVSEIQRNNNRGDFLLAVGRTVKEDYLFDNITKYFRESQYHRGEFKLRNFKLAFQQRPSTLNSVARDNYRYFFDSDHYSFWNNDPPIKALYLTDTLDFRGYMKYCYHNECDNLSHATSDRLHFLTNTADAVAMTALEDTGLVECIPRTFGNVSEVYTSDSGEFQSPGYPTKYPNKADSIWTITVSSGHVVDLWFTEFDLEANECKSDFVDVWNDYDATSLIGRYCGKIAASKIHLKSKGRTMQIRFRSDDFITSKGFKAKWKASKGSSLIGSSLLSYLCLALIFLWKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8D2</accession>
    <name>A0A6P8H8D2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inactive tyrosine-protein kinase PEAK1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551761.1">
        <property type="nucleotide sequence ID" value="XM_031695901.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H8D2">
        <property type="interactions" value="1277"/>
    </dbReference>
    <dbReference type="GeneID" id="116289028"/>
    <dbReference type="KEGG" id="aten:116289028"/>
    <dbReference type="InParanoid" id="A0A6P8H8D2"/>
    <dbReference type="OrthoDB" id="5975812at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051511">
        <property type="entry name" value="MitoQC_Scaffold_Kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
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        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
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        <location>
            <begin position="692"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="734"/>
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    </feature>
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        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
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        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
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        <location>
            <begin position="1028"/>
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        <location>
            <begin position="1044"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="RefSeq" id="XP_031551761.1"/>
        </source>
    </evidence>
    <sequence length="1485" mass="164627" checksum="4662B95436578E48" modified="2020-12-02" version="1">MSGCSNYAENLWKKGKCSNCFRSKEQHFTGTKDVPHANGDSCLIKSNHEASKSPNIKTNGLPNSKRQTSSEVSVDGEEFIKRGTVKRAGIVYRAPGSEFSKRLSSYQATLRINDSSSSETQNTALSADNRGTTDSLDKPKPVYISTRERTASKASHDSEDDKNVRCSVWSSESSITEPKTHLHDSKNNVNNNANENFRCAASADLPKEKEISRNNKVEADDIKQDQVNKRDVSVKESRQYENSSISQRKNTREEKNLNMDSKSIESNGKDGEYMQMKNNVCRGMEDDNKTDVDATDKIQSTYTCESDDKTKRIINKSDSLTSANKQNGVISPNNIIKDVSDRPSNGPIEPRHINHTSSSCETQETLNLEPHYENRRSIDSDGKDSLSSNSPVLERPFISSVLSTADRPESIAFKVQSDLGELRESSIFEDIVVEPSETSNNSDSSKASSSMPSSPVTDTKTSTESQRNKSTNGNGEPFDSHPRTGKQQGTIERRHSNPDVTKLVEGPCYANADVKPKTKPYKVVDISAGIPVHCNEDEHADTPPLPPKEKELNRQKEDSIPDHYYCEPPDDIVPDYKKLTPQNKDPPPIEIKKDPEKGVPPLPKAGPVPRPRSQLPSHSATLPRPVPRAVKVEVDIKDVTRGSRPVSQVVTRTHKKEAPKPPSTSSIPSRKHTSDLTPPTSPTGKHSPGSPECSQYQGSGNTVDSKDPTIKPKRMAPPPPKAANSTGRVSSQKETQIESPRDFPTPSPAGQYKQPESSQSSKAQSKSGSGIKRALSSWKRLSGRRKNKRKLEISSPILVKEENESNSAQKEEMEKKVSEARSTSPVCTNIKDRQRDSTILSQKPPEEAQPVVGTEVKEANSSPQLPARKSGRSYQNFPFSKTDIKKPVKPSRPARAVIPVVQVKPEVNQKPMSQNIQHEAPAYLEPCTGQLTLKVEAALANLNDAKILAETLTRVEQEKLGPLPEVPRSRHVHFRFNETADKTGKPAPKQSPKRPVTAVAPTVVNRQADMKSRQPKYPSRPPNTKPFASDEKKRSKSLSEQKTAETGTGNSRSRSMSTQDNPVKKRYDKILELHRQTLEDMINSSKAVLLPGDNISLSNTKWNDYVVCGSPMDIDVPGAVCLPVVCPKVDEELTLLAKVKFPKSVTEDMSQRTAYMQDMAVTVSLPSHPNVSRTITHFTDYLQGEVFGVKNASDFETLVTITDQVPVESVLEFVERTKEEHLELPDEYERKVCILLLQLFSALVHLHKEGIVHRDIRLNSLLLLDHGHLVLSNFSHVLQNSGGDNSSSRFEYHIDSVGHIGRDPCRIPPEIHKAYNCGKLMNYEKCDVFAVGCLIYELLHENNPFAADSSLLTRDYTIHDLPMLTEASRFTRGLAALASGLLQRDPQMRMLPDEALKLLQAYLWGPEDLDESCLESSASDWLETERAHAVIMIARSQSHGSVVGGDEFVENFLKYEYLVTLTEEVVLEGYNALALQNSSNLAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H934</accession>
    <name>A0A6P8H934_ACTTE</name>
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        <submittedName>
            <fullName evidence="8">Transmembrane protease serine 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116289280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552036.1">
        <property type="nucleotide sequence ID" value="XM_031696176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H934"/>
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    </dbReference>
    <dbReference type="GeneID" id="116289280"/>
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    <dbReference type="InParanoid" id="A0A6P8H934"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR24252">
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    </dbReference>
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        <property type="entry name" value="HYALIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00089">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
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        <property type="entry name" value="Tryp_SPc"/>
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    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027701565" evidence="5">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="59"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552036.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35136" checksum="84AFF46B838AC3F0" modified="2020-12-02" version="1">MLFAVFIIFGVILQNEEGIAEKRNLDSFPFCGWRFRKSAQSRHFSWSTLMKNYEYNKRIVGGKESKQGSWPWQVALFYNGTQLCGGSLVNHNWIVTASHCFHETYSSTDPKMWTATLGEHKLKKEESFEQIRDIERIILHPKYKSMLFEGIFDTPPDYDIALVRLKEPAIMDENVYPICLLRPHTKFHWGKVCYISGWGHTKFNGTQPEALNEAQLKLVSTNTCNKKLSYSGKIHGRALCAGFEKGGVDSCQFDSGGPLSCAVNGQYFLTGVVSWGHKCASPHKYGVYSNMMVMTPWVFEKMRNIDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9J7</accession>
    <name>A0A6P8H9J7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116289094</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031551843.1">
        <property type="nucleotide sequence ID" value="XM_031695983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9J7"/>
    <dbReference type="FunCoup" id="A0A6P8H9J7">
        <property type="interactions" value="2807"/>
    </dbReference>
    <dbReference type="GeneID" id="116289094"/>
    <dbReference type="KEGG" id="aten:116289094"/>
    <dbReference type="InParanoid" id="A0A6P8H9J7"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16213">
        <property type="entry name" value="EFh_PI-PLC21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF149">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="16">
        <location>
            <begin position="529"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="645"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="469"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="823"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="908"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1178"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1007"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031551843.1"/>
        </source>
    </evidence>
    <sequence length="1267" mass="146113" checksum="FBAD903DA8988EB2" modified="2020-12-02" version="1">MAGGEVYFEKLRPPEVAECLTRGSTFIKWDDDSTTGQKCVVKVDQAGHLIYWKAEDKETDFLELTFIRDIRTGRSARMPKDPKLRDSVRTGGTDEELLNKTVTIVHGTNMVDVIFINLVSGSANIATQWTEALNKLIHNILAINVCPSTYLQKHYTKLCVTVSPDGKVLVKNIIKYITSSSKEDRKRVQEALQSVGLPHGKNDLISLDEFTFEIFLKFYNRLCNRQDIDKIFSEIAKKKPYLTTEQVVDFINNNQRDPRLNEILFPYCDPEKAQEIINKYEPNKDFVKKGHFSVRGLTRYLMSYDNTIINPDRLSIHQDMTQNLAHYFINSSHNTYLTGHQLTGKSSVEIYRQVLLIGCRCIELDCWDGRTEEQEPVITHGMTFCTEIAFKDVIEAIAECAFKTTDYPVILSFENHCTPKQQSKMAAYCVNIFGDMLLDKPLEEYPLEDGKPLPSLKSLLRKIIIKNKKRTSKREEGNENDTSAQTTITDNTTENGENKPEMNGEVVENNDNSKDRDQVEEEAAPDTALSELVNYIQPVHFKSFENSAKKNRSFEMSSFVETVATGQLKEKPVEFVNYNKRQLSRIYPKGTRVGSENFMPQIFWNAGCQLVALNFQTLDLPMMLNLGIFEYNGRCGYLLKPSFMRRPDRTFDPFAESTVDGIIAGAVTVKVISGQMLTDKKVGTYVEVDMYGLPADTVRKKYRTKVVPNNGINPVYDEEPFEFKKVVLPSLAVLRIAVYEESGKLIGQRVLPVDGLHPGYRHIKLRNECNQPLCLPTIFVNIVTKDYVPSGFEDFAAALCDPIAYQSQEEKRQQQLAALLDEEEEVDGDEVFEERPPEETTKGTSTPKNQNQQPEEKSKFKSMSFKRSEPRDSLSATEAILGQRRGSSISQFVHRESLRDTFGAGMKPQLQHQVSSPYPVSGRAQSLQTPPPSETTALCKRTFSAKRREGKTTSLIITSEPVYHWSRSSTLVPKRRPKTEEDMSWNHIYVKVEAMTIEQLKEQKNYVKLLQKNKKEHDILVKKHEKEKDKLQKGHFLEQDKMFKDLEKEKSSLKRRIEKELRKAEKKGSYEETYKRGMDEINSLSKAHDSKVDGLKRVHRDHMIELLQRQLAEQLEFSKKQIDPQYEELDRVLQQSHEDQLKLLDDVHARQMNDLKKDQDKMNREELKFLSRHVKEKDELQRRKREQNKKHIEQSVKERHKMKDFHEKEKEELIVEQQKISEQMKSDKDKTVKELQALYDKKYQSIPSCNLESIHANLFAEDKITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAC2</accession>
    <name>A0A6P8HAC2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290483</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553384.1">
        <property type="nucleotide sequence ID" value="XM_031697524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAC2"/>
    <dbReference type="GeneID" id="116290483"/>
    <dbReference type="KEGG" id="aten:116290483"/>
    <dbReference type="InParanoid" id="A0A6P8HAC2"/>
    <dbReference type="OrthoDB" id="165498at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="346"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553384.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56401" checksum="42BB191214C41EA0" modified="2020-12-02" version="1">MGSRAMQSLRVGRVLGILIKGTSSCNLSFVAPRCPRNRLITTAFICSNRRHLCNSQSENVGQNNSGNDEKLVSSRTSVESTEFKENISNFVKSFGISQNIDTVIPAFIHKSYLITHASGLKKQHHDNEWLALLGVQTSKRFLTELLTLNFPHFSAHQLWDIQNGLLERQFQLIAKDFEMESLIASEISINKNVLAQTVMALVGVVYMHEGPAKARQLVQEKIISNLNEEQIKEIIKLQHPKYILRSLMKESKDEPLRTRFLKRNTPKSGASQSKAKLYKVGVFRGDKCLAIGISDSAEHAEKKACQTTLLNHFPEELRGFELLYEAEDIDTEEKIDFGLMTSRQRIVTIEKEIEDFGFSIKGGEKKKLKNEQWLVFNYYSPIFISSIVPGGLADRLGGLRIGDVILAVNDRSLVGIDHAGAVKILKLVSGTVDLTVKYSKQVLVTDGVETEFRKMKRQKRMAELTSEVWAEWHQAQANQHPEKYADVLRLEKDIAADQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBU2</accession>
    <name>A0A6P8HBU2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitogen-activated protein kinase kinase kinase 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553106.1">
        <property type="nucleotide sequence ID" value="XM_031697246.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HBU2">
        <property type="interactions" value="2247"/>
    </dbReference>
    <dbReference type="GeneID" id="116290241"/>
    <dbReference type="KEGG" id="aten:116290241"/>
    <dbReference type="InParanoid" id="A0A6P8HBU2"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001803">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1377"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1216"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1287"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553106.1"/>
        </source>
    </evidence>
    <sequence length="1642" mass="185918" checksum="007792567FDAC73C" modified="2020-12-02" version="1">MADGDNTDEFDKTPLSPIVGTPCDELDAAELFEGHYNNQDVFAMGDEQDSKSYLSSFGEKNDSECDSASSELEDIYSGELGVTPPRNIRRNKERSRTQRKGQGLCLKIPVKVEVEKQKKRVRESSQTQIQNERAFQREYKRSSLGSTLGNEDLSRSLNLPNVKIDSKNRFMSLKCTRRDNRKEDSPKHRLTRSESDPKDLGQSLTTLSQSRQEFIRTFSLLIKIGAHARKQRDSQFASTELERQNSEEHKKWQVKLCLALWLELRAWHGGRTMEEQDKYLMEERANVEEVLDEFIKFNLNNVVSNGDVDDNLTSVKDNVEQIVEDEAVSSVNNRAPATNASATPTVVIDDYELKDSNDKNSNNGRNSTKTDNSPNEPRESSPSSDSKPRKENLNLDLSSGGKTRLKSLKSEECMPRCSTPENAVPKDRFRKRLEFAIMEITKLFDQLESVEVLYPTKRAVGEANPKYLISEFNRNVDALLLWLNVTKELLHQLTLISRFLGIDPEMQDMWQDWIHMGMGMLGGSTESDSCVATSTTSEESYSSGSSESLDEELPSTPTCKRQLSHETWSPKPPMRSGSNISQFTWTLTSRYRPFVDRSIKKFGLVKLGKRIGDILDVTLLKTRQVLYPEGPQPKHNDHSQMSISEWHASVSHLENILYRDVATEQRPRTHSSPVIRNIVLERSPYMLPWKSIFEELGLPSIRDLYLFLARIPLDISHECIRLRLEHRPKGEPSSLSIRQLLKECKEVILGAVLVKDYYLCMVDGIVSPEDYDHEKLENDIEEFEQDLQSMLEVYFEYLHNVIHMLQRLPQASKGLKNLLEEEWVFVKHKYQHIRGGAVAGGTRFCVMAAGLLESTADFLESGLDQCCSDLHDNTDHSEDVRKKVLEACRSLKHLFNEGRERASKALGFTKKLKIDLENAAKFSIDVPVNELLSVLERTEHSQVVVAPTTGLLMFVPKHLRDDKCQIIDLLNACCGLKKGQNKEPGHGYLLVMQSSKVATPVWTGHRIIITLTVDTRISLADIQVDGLILVVNKSHQVEEQRNCFLHSMGIFVTMIKERTSSHQAISESLDSLQDAALLLGTKIINAVNRANENLDGEMFDADENERHKLCQNTVETMYGCFNFGFEYLKEIARLVSGDPRKKLGKYMLCFARKWIKFVMEKCERGRGTRPRWATQGLDFLTIAIDGKVLNSMPEAEFQQLKKQINDCISHVVGSANGGPSSSAYRPHSPAVGPSPVLGKSSGTSLRRPYSWPANRSPRPEDSENNTNNRHLSEPHKVIHFQSLAEDAKSPEGLGSEHDEEDAVSEKPKTSPVPHHKDSMDYSMAPKMEKVRHALRRLEQERNSYLVEKHVIGKVSSKHRDITSELANISNRRVPFKWQRGMKIGEGQFGKVYACVNLDSGDMMAMKQIRFHPNDHSEIKDLADEIKNFEGIQHDSLVKYYGVELHRDEMLIFMEYCADGTISDIAKLGLPESMIRQYTMQILVAVNVLHERGIIHRDVKGANIFLSSNGLIKLGDFGSSIKLKNQSKTMHGEVMNVRGTVAYMAPEIITMDKGSGYGRAADIWSTGCVVVEMATGKPPWHEYDNNWAIMFKVGDGAIPAIPDTLSEEGRDFLHSCFLHDPRERPTANDLMDHSFVKVAVNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCN8</accession>
    <name>A0A6P8HCN8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290502</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553401.1">
        <property type="nucleotide sequence ID" value="XM_031697541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCN8"/>
    <dbReference type="GeneID" id="116290502"/>
    <dbReference type="KEGG" id="aten:116290502"/>
    <dbReference type="InParanoid" id="A0A6P8HCN8"/>
    <dbReference type="OrthoDB" id="10529242at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553401.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14387" checksum="05BEC216D7B4F5DA" modified="2020-12-02" version="1">MAAKAAKLIKEKRTMSNEKRSSTPCVSTATTTSATTTSTSTSGDNTREDNFPSLGRPQKSREPWSAEDTLKIQTKLRHLIKMSSLPSRLAIREQFKSSVPSIWGRQSTKEWQDRCVEKVRSLWKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDS9</accession>
    <name>A0A6P8HDS9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Fibropellin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116291536</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554579.1">
        <property type="nucleotide sequence ID" value="XM_031698719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDS9"/>
    <dbReference type="GeneID" id="116291536"/>
    <dbReference type="KEGG" id="aten:116291536"/>
    <dbReference type="InParanoid" id="A0A6P8HDS9"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000520">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000045">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
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            <dbReference type="Proteomes" id="UP000515163"/>
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            <dbReference type="RefSeq" id="XP_031554579.1"/>
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    <sequence length="644" mass="68576" checksum="136B33F96B48D573" modified="2020-12-02" version="1">HDDCKPNRCQNDATCVDNLNGYSCTCKPGWNGQNCETDINECSSRPCQNGGVCSDKINGYECACAPGYTGKNCDNDKDECDSNPCLNGAVCHDLVNGYSCSCAPGYEGVNCQTDHNDCSPDPCKNGGTCKDKVNGFECSCKTGYSGKTCQTNIDDCAPKPCQNGGTCVDGVNDYTCQCAPGYTGDNCQTDIDDCASNPCANGGECIDGINSYRCNCAPGYRGANCEEDINECASNPCVHGSCTDKVNGYTCSCNPGYTGPRCNNNHDDCASAPCKNKGVCTDLINGFKCTCAPGYTGDTCQTEINECDSNPCQNNAVCTDRVNSYTCTCKPGFMGTNCEVDIDECVGRPCQNGGTCINGVNKFTCKCTKGYTGTRCELNVDECASKPCKNGGLCYDLVNGYRCTCAAGYRGDNCEQDINECASVPCLNGGTCEDKVNSYRCKCVVGFTGDRCQINVDDCASKPCKNGGVCIDGVNKYTCHCPAGWKGQQCTELIDMCSKNPCQNGATCHDEVNGYRCACQPGYVGATCNRKCSRCKPHICLNGGTCGISSRLRVWFCRCPPGYVGTRCETASGICTRKPCLNGGSCCEDKNAISGYKCLCPSGYTGGNCESLIEYHKCNRASMLDHYNKGNCGIRSLCFNTTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEM2</accession>
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        <submittedName>
            <fullName evidence="5">Lipoxygenase homology domain-containing protein 1-like</fullName>
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        <name evidence="5" type="primary">LOC116288379</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <dbReference type="NCBI Taxonomy" id="6105"/>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="5">Tentacle</tissue>
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        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <sequence length="142" mass="15939" checksum="2A8B309141E13E93" modified="2020-12-02" version="1">MDFYSLKAVLVVFCLTVCVEFAHPSIQTVLYRIEVVTSDEWGAGTDANVHIKIYGSLGNTDSIKLTKGGNLFEKGAHDEFVFVAKYVGNPITKVEVMRDTKGLFDDWKLDKILVKSNAPIVYKFAFNAWIPPNKWIKSYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name type="scientific">Actinia tenebrosa</name>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031551047.1"/>
        </source>
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    <sequence length="159" mass="18571" checksum="EE4E75E6B296AE89" modified="2020-12-02" version="1">MAAESLGGFLYGYKKGQIHPTKSEVVWVNKRYNPTDLRSSAPVPRSKFVLEQKPSRESAIPSHWKKDVEPSLKTFSRYFEEEKWYPSTQATRCEEWSTLRQILPSRGIPNRVIAPRWGTEMPTDSKFKHLTEKKFPHINSPMTRGVDDMHLTNRLFKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEQ8</accession>
    <name>A0A6P8HEQ8_ACTTE</name>
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        <submittedName>
            <fullName evidence="15">Metabotropic glutamate receptor 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116291835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554909.1">
        <property type="nucleotide sequence ID" value="XM_031699049.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBP1_GPCR_family_C-like"/>
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    </dbReference>
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        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
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    </dbReference>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028205061" evidence="12">
        <location>
            <begin position="25"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="797"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="569"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031554909.1"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124186" checksum="BE0152FF1B0AEEC7" modified="2020-12-02" version="1">MAFLLRVLSFLLAFSLAFLQVVEAEGIYKEGEVVLGALLTVRHKNSDDSCGALKPQGLAYVEAMLYAIESINRDNTLLPNITLGYDIVDSCDSPALANKMAFEFVTRNQATQVRYASNDIKNFKKFFGELRKPVAAVIGTGDSSSSVVVASMLQVGNISQISPFATSEELSLQYFKTFFRPVPPDSQQAKALADVIDYFKWKYVMVIGVDTSYGRYGVMALENESQERGTFCISEISYFPPSGYQNKITTIVSKIKRAENIKVLVLWGGPTTSIHFIQEAYRQGIYGKTWLAPEGWSEATPLFKDQYLPIIGGFVGTKLRNYNLENFYQHMLKLDYSYDRVRNHTWWREFWMQEKQCQTESDCNFQEFQISPKTYNDMYTAYLAYVIDAIYSVAHALDAIYRCTEKENVECPSTKPFLRAKEVLRYMSGVAFKGTTGSVEFNKNGDSISSAAYDIVNLHPGTNGPDLKIIGNWDRGQEQRLRIDNSSLYWNNGTDKIPLSICIKPCSPGYMQTATVACCWKCIKCPIGFISNXYSSPNCTECPLDKMPDSEQRSCIDLPEVNVTFYDTQSIAILIVAGIGFLAVLFVLGVGIRYRSTPIVKSSNREMSFLFLFGIVVGIIAGVIQLARPTELICYFLNPLHALYYTLCLSILLVKTNRLVKIFEFSFVTSNIGQLCNSKHSQFLILFLLNGIAGAMVTIWHVFDPPFVYVTIEPLRWKHLGCSDHKETLGLALQGTLYAYQLALSVLCAYYAFKARNLPANFSEARYIAFAMYMQLMCTICYATLQNSVEGNFLTTFSSAIVVLSSFGFLICMFAPKIYIILKFPEKNTSEYVKALVANHSLDRNFSHVSVVGRSKFASSVAKAKLQTETQTSSMSNISSGDGERGDSKKLKTLSVSFQDIVEEAWDNHKTSACALKNNDVAKETLRDENGACISGNESPVKYNGITREAPPNQVKSSQANIYADTGSPIKSSGKETKSNQNRGYINYANTGSPIKSNSQIKDAQTNVNGVYNNCADTGSPLRSNRVTMETKCHQNQAVFEHSGTGSPTKLKSKIDDTPEVWMKQDKTGSPIKFSGVNEEIENKRETMNNTPLEENQIQEVNKMNIYETCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HES4</accession>
    <name>A0A6P8HES4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein 131-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551127.1">
        <property type="nucleotide sequence ID" value="XM_031695267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HES4"/>
    <dbReference type="GeneID" id="116288472"/>
    <dbReference type="KEGG" id="aten:116288472"/>
    <dbReference type="InParanoid" id="A0A6P8HES4"/>
    <dbReference type="OrthoDB" id="168404at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055435">
        <property type="entry name" value="Ig_TMEM131L_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056311">
        <property type="entry name" value="TMEM131_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022113">
        <property type="entry name" value="TMEM131L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24495">
        <property type="entry name" value="Ig_TMEM131_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24498">
        <property type="entry name" value="Ig_TMEM131L_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12371">
        <property type="entry name" value="TMEM131_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transmembrane protein 131-like N-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131 second Ig-like" evidence="2">
        <location>
            <begin position="169"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L third Ig-like" evidence="3">
        <location>
            <begin position="398"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551127.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="66441" checksum="B589CBA5FA930EE4" modified="2020-12-02" version="1">MKENKTKHHSNQRKSEVFQVTHRICMMQCNPMPGPGMYHGDVGDLRFSGSHVESGSVRERRDGLNTRQIRFDPSYLDFNEQSVGMPRIKTVTIINPNTEQSLHLQSISGSTVHFHASFFQAKIVQPLGNTTFEIVFLARLVGNVENTLFIHTSKGVYPYQVFGVGVPNPYRLRPFLGARVPVNFSFTSLINMHNPFNSPIQVIEMYSSGGDLHLELPSGLEEAPQKHWEIPPYETKALMRVSFEGRSPNNHTAFIRIKTSNATPVTEFLILPVEVEVTAVPGLFPSVDLLDFGTLRTMDEPKAVGVYLLNSGPKQVHISSIIAEPANNAVSVTFTPLNLKPGNKYIKVATVTFSAYHVKRSRQSNGKIQIKTNSKTALKLELPYQANVLQGTIAYSVSKTRFYVGKPPFVPVIRELPITNTFAFTMVIYDAAFPPEVESLFSIINFTKPAMISPQKTSTPFYVQFLANGSDTAFSTILRVYTNASIFTIPIHCYDGKVKYIIDGLEEDIVDYGTVGTREKRTKLLKIYNTNPVEVTISKITCNVDFASVKLLDVRLNGSKNNNNNTSSSKVNELRKSEHVKVRRIKGTISTFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF31</accession>
    <name>A0A6P8HF31_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin-2 heavy chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551180.1">
        <property type="nucleotide sequence ID" value="XM_031695320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288511"/>
    <dbReference type="KEGG" id="aten:116288511"/>
    <dbReference type="InParanoid" id="A0A6P8HF31"/>
    <dbReference type="OrthoDB" id="306254at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF48">
        <property type="entry name" value="TRANS-GOLGI NETWORK-LOCALIZED SYP41-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="949"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551180.1"/>
        </source>
    </evidence>
    <sequence length="1008" mass="115186" checksum="3A7E5482DC9A0D85" modified="2020-12-02" version="1">MDDLSKVQTNEFESSSLKSLENGLKSSSESLGKHSLSNGSIVKDKTDGVFVDDSPQTNEKNGVSIGQDIGIANGIKRSDKEDSSEDLKDKNDKGIAKINISKKDATRSDSETSSTLSSSSDESEDDESNKKQENQKQVNVSQSKDKNXAAGLCNEELTLKLQEAWSRYEELKGKNDEQEQKLADANEKNKNLFDTTENLKHINEELQEELKSKDQQLQSRLFVLEERDSTIEKLRSELADMKSSRESMENELKDAREELGKLQSAQGDQEQSTKEWIEAFKQLQTKADDQDEEIGKLKDQLEMAKKEIEMHGTDKTEVEKKLQEELASAKNTIRSVNQANSKLEAKLSNSQTITETAEVESKKLKAEIKSLRDKIKWLERRRASEKEGSPNSTPRSESASRAAEQMDRKQSHETLRRVQERVKELEQKVIQVNDEKQKLKHDYDEAVKALEAVDKVYSIRELALQQYKTELDEANELIKQQSSEIQDLKPEVEQLKVELKRAEENKEENQAAREELKEQITKSKEANRIYKEEIEDVRKELGDQVHELQLAQAKGRERGKKNQILELEVREMKETLQISKSVIEEKEKNMESLREDLRNEKKNCKQLQQDLEEVDYLKKKLQLIEDEKARIIEKLKRTETDLKETEESLKKSCLKIKEIGKEKETLSRNNQKLKSKCEDQDYQIQTLQEVVANKESDIEQQLIALIHTRSQVDELNLQLQEMWASYSADKALWKNKGGRSIRRRHRSAPSKRIQQASPPLYQSPPESKMHSLAHRRLVNKLGLPVVNPDFINTMHKDIQPESTQKSTQNNEVQDVSDGPPNNLKASDKTSQTPDQTKDNQQKLSPRPPPDDIDKRKPHRPLSSYGIHTHPPMNGEYNRTFSGMRSEDLWLHTDGLSIASGDTDEEIAKYLVNKGDRVMIQSKVVGDDNLNISGVVKYVGKVGKKTNSPVYVGLKLDQPFGDNSGTVGGKQLFSCPPRHGKLIKMSEVNAVMHPRTKNYNRVKSMTLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFH9</accession>
    <name>A0A6P8HFH9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock cognate 71 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116288647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551335.1">
        <property type="nucleotide sequence ID" value="XM_031695475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFH9"/>
    <dbReference type="FunCoup" id="A0A6P8HFH9">
        <property type="interactions" value="2619"/>
    </dbReference>
    <dbReference type="GeneID" id="116288647"/>
    <dbReference type="KEGG" id="aten:116288647"/>
    <dbReference type="InParanoid" id="A0A6P8HFH9"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031551335.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="71224" checksum="033776BF8642757D" modified="2020-12-02" version="1">MAKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLVGDAAKNQVAMNPVNTVFDAKRLIGRRFEDPGVQDDMKHWPFHVVSESGRPKIEVEFKGEKKSFFAEEISSMVLNKMKETAEAYLGTKVTDAVVTVPAYFNDSQRQATKDAGVIAGINVLRIINEPTAAAIAYGLDKKVGAERNVLIYDLGGGTFDVSILSIEEGIFEVKSTAGDTHLGGEDFDNKMVTHFVQEFKRKYKKDLTKNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGIDFYTSITRARFEELNSDLFRKTKEPVEKALRDAKLGKNEIHDIVLVGGSTRIPKIQSLLKEIFTDKELNKSINPDEAVAYGAAVQAAILHGDKHENVQDLLLLDVAPLSLGLETAGGVMTTLIKRNTTIPTKKTQTFTTYSDNQPAVLIQVFEGERGMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGRENKITITNDKGRLSKEDIERMVQEAEKYKDDDEKQREKIQAKNSLESYAYNMKQTVEDEKLKDKISEEDKTKILDKCKEVIEWLDHNQTAEKDEFEHQQKELEGVCNPIITKLYQGAGGAPPPGGFPGAAPGGAAPGDGGSSGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG69</accession>
    <name>A0A6P8HG69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome non-ATPase regulatory subunit 11A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553958.1">
        <property type="nucleotide sequence ID" value="XM_031698098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HG69"/>
    <dbReference type="FunCoup" id="A0A6P8HG69">
        <property type="interactions" value="2677"/>
    </dbReference>
    <dbReference type="GeneID" id="116290977"/>
    <dbReference type="KEGG" id="aten:116290977"/>
    <dbReference type="InParanoid" id="A0A6P8HG69"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000003">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="249"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031553958.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50360" checksum="8A1D19352E385DBA" modified="2020-12-02" version="1">MAYVTRVGDSASSAGLPLVWRKFCPICRLSLANDLEKAKEMESTDPKQAKKSLYFIVKLNIPMEDDELVKIKEQAILILASLHSKTSEAEDLGGLIKFIRPFLQSFSKAKAAKLVRTLVDCFLDMEASTGMEVELCLECIEWSKQEKRTFLRQALESRLIGLYFDTMNYTEALKLGSKLLKELKKLDDKVLLVEVQLLESKVYQQLSNIPKSRAALTSARTTGNGIYCPPKLQASLDLQSGILHAEEKDFKTAYSYFYESFEGFDSIDSPKAVSALKYMLLCKIMLDSPDDVQSIISRKLALRYSGSQLIAMKSIANASHNRSLLEFQQALTTYKKELTDDPIIQTHLDALYDNLLTQNLLRIIEPFSRVEIEHVAKLINLPQDVVEKKLSQMILDKKLHGILDQGSGVLVVFDDATPDKTYEHTLDLVHQMGTVVDALYTKAKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGN0</accession>
    <name>A0A6P8HGN0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116289001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551737.1">
        <property type="nucleotide sequence ID" value="XM_031695877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289001"/>
    <dbReference type="KEGG" id="aten:116289001"/>
    <dbReference type="InParanoid" id="A0A6P8HGN0"/>
    <dbReference type="OrthoDB" id="5990167at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="964"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551737.1"/>
        </source>
    </evidence>
    <sequence length="1232" mass="136591" checksum="AC7D73DF5A1BF75B" modified="2020-12-02" version="1">MLLQGRVYNEELIYDAIIEAGVDVNKPDKDGKTALLHDVWDVKVVHALIEAGAHVNITDKDGKTALFYALSKDHEEVTHALIKAGAHVNIIDKHGKTALFHAVQNEKVTHALIKAGAHVNIIDKHGKTALFHAVRNEKVTQALIKAGADVNITDKDGKTPLFYSVYNEKVAHALIKAGADVNIIDKHGETALFHAVRNEKVTHALIEAHADVNKIDKDGKTALFHAVLNEKVTHALIEAGADVNKIDKEGKTPLLYSVYNEKVAHALIKAGADVNITDEDGETALLHAVRNHHEKVAHALIEAGADVNITDKDGKTALLHALLKHHERVAHALIEAGADVNKTDKDGKTPLFYSVYNEKVTHALIKAGADVNITDXDGXTALLHXXRXHHEKLAHALIEASADVNITDKDGETALLHAVRNHHENGKTALFYSLYNEKVTHAIIKAGADVNIIDKDGKTALLHAVRNHHEKVAHALIEAHADVNITDKDGKTALFYSLYNEKVTHVLIEAGADVNITDNDGKTALFFAVDNEKVIHALIEAGANVNITDNIGNTLLICVFDNSRTVNSKKCEVLLKSGSSLCETTKKQESVFHLALSICQDNIFSSELGDLQKHSIWFDIMDALKLFSKSGESKVAVNKRDMHLNSPLHLWASFHLVSPLEYHKNVCHGYSFKHMLKRVLDVLVSCGIKLNYSNEREQTPLHVCKTWTAVELLLDADAKPDVTDLSGCTPLLTAVKSTKCLEKDSKCFFPDVDQTPDEFWKEVLNRRLDPWTADKDGNSVLSILVTEGAECLTTALIEAACHLKCVQSDAIGVPLLITICKDKSVDKEWKVDLVKTLLKYRKSLAHTSLSNKDTALHISCKNMLELTEESVKTSVHWKIAQHLILCGADVKSADKEGKSCLDIAESCPDLKELLSTPVNIEQVPPLIDLWKVPNKVSGKVSKTHQGQLAKVARGFDSHQIETVFYFKEALDNGTFGLVFVGMNIEDGKEVAVKRIEAMRVDIENVTKEIEDLKLVLSCSNVIQCLLCIIDDDFLYVILELMEGNLDDLLQEGYDFVINQETKLCRDICTGLDYLHNHDIIHRCIKPSNILYQGIHSEIKLKLAFFGLRSQMCEEQRTSALTDTYESLTKVRCWMAPEVLQSQSHSKSSDVFSCGLVIHYILTNKKHPFARRGSSKENLLAVSIETVENIAQDKIELDETISSDAHDLLQGMLDHYKRKRISISNALKHLFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGT5</accession>
    <name>A0A6P8HGT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116291966</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555061.1">
        <property type="nucleotide sequence ID" value="XM_031699201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGT5"/>
    <dbReference type="GeneID" id="116291966"/>
    <dbReference type="KEGG" id="aten:116291966"/>
    <dbReference type="InParanoid" id="A0A6P8HGT5"/>
    <dbReference type="OrthoDB" id="5963377at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22827">
        <property type="entry name" value="Gal_Rha_Lectin_SUL-I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028064834" evidence="7">
        <location>
            <begin position="18"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="315"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="425"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="8">
        <location>
            <begin position="535"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="340"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="353"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="450"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="463"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031555061.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="72036" checksum="2A2E6669A12748C5" modified="2020-12-02" version="1">MMLSLWYVFACLTFAAGEESLKESIIRELKELADAADDPQAWKSDPQAWKSDPQAWKSDPQAWKRDPQAWKSDPQAWKNDPQAWKEDSQAWKNDPQAWKNDPQAWKNDPQAWKSDPQAWKEDSQAWKNDPQVWKNDPQVWKNDPQAWTNDPQAWNNDPQAWKDDPQAWKDDPQAWKSDPQAWKEDPQAWNNDPQAWKNDPQAWKNDPQAWKEDPQAWKEDPQAWNNDPQAWNNDPQAWKNDPQAWKNDPQAWKSDPQAWKDDPQAWETNPRADEDTDQDIENESLNKYEDEDEKTMDEVQNSPHFYRPPKRRIHVRLVGGKTLNEGRVEVFYRGRWGTICDDFWDKRDAAVVCRQLGFPGVRAAHGMARYGEGRGRIWMDNVACKGRESNIGLCRHSGWGRHNCRHNEDAGVKCMPRRSNTKVHVRLVGGNSRNQGRVEVLFRGRWGTVCDHFWGRNDANVVCRQLGYPRALAAVGGARFGQGNGTILMDNVRCNGRETNIGMCRFAGWGKHNCRHSNDAGVTCQPRQPIRTYRLCEHRSGILRCPAGRKLWIVYANYGRTTGKAVCPHKSMRTINCRSPFSTQLIRCACHGKTSCNLYAKNEVFGDPCAGTFKYIEVRFRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHG9</accession>
    <name>A0A6P8HHG9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kallikrein 1-related peptidase b8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116289265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552020.1">
        <property type="nucleotide sequence ID" value="XM_031696160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHG9"/>
    <dbReference type="GeneID" id="116289265"/>
    <dbReference type="KEGG" id="aten:116289265"/>
    <dbReference type="InParanoid" id="A0A6P8HHG9"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028154248" evidence="2">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="68"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552020.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21386" checksum="2EEEBDF43F0EBED9" modified="2020-12-02" version="1">MLKLVVFLVLLALVSQNNGRKKRYSVSIDDIDPYPFCGHRFLQHGTEFGNDLRKRRSLEQGKIEGKRIVGGTESKQGSWPWQLALLLNGTQFCSGSLISREWVVTASHCFHDSYSSTNPKFWTATLGEHKLQEKEVFEQVRGVERIILHPNYKSMFLEKIFDTPPDYDLGEFIYCFHIFICVHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHZ6</accession>
    <name>A0A6P8HHZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552242.1">
        <property type="nucleotide sequence ID" value="XM_031696382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHZ6"/>
    <dbReference type="GeneID" id="116289438"/>
    <dbReference type="KEGG" id="aten:116289438"/>
    <dbReference type="InParanoid" id="A0A6P8HHZ6"/>
    <dbReference type="OrthoDB" id="6017871at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552242.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39828" checksum="62689FC842BB5EAB" modified="2020-12-02" version="1">MEAQFADERKPVPVITDISQRAIRERNPEDPLILASENGTLDYDSTDYGQPRKSHKKKDRYGNYASAIRKADPQSELVKRKQKYAAALEGARVEDDDLDEFYKGTGINLCEPDIMSTVPVDRIKKQYLSSAKEEGKVVPRTEEAPAPHHIEPQWPPREDMLDGPIKPRVIQISSEGEKHKRDGVDGGHIKPVNTMKDKWQNLPQKYKNKPMGVNKPTIDIVGDRQWITHFRPVIDEGKAPEEPEWLKTVRNRRWLSTVRARFPEDEQERIAFERRSTTPRKFKKPNPHTVMRSSSDLDDEFEEVMRRRRKRSDSADESSYLTKSASTFVKSASTFVKSASSFYSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK51</accession>
    <name>A0A6P8HK51_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uridine phosphorylase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116293467</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556753.1">
        <property type="nucleotide sequence ID" value="XM_031700893.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556754.1">
        <property type="nucleotide sequence ID" value="XM_031700894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK51"/>
    <dbReference type="GeneID" id="116293467"/>
    <dbReference type="KEGG" id="aten:116293467"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031556754.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35761" checksum="2C219F35CCF710AB" modified="2020-12-02" version="1">MSDEEEKQTIQFVKNPHLSSLEDDVLFHIGIKAKDGLKEPFGDVKFVCMGGSTDRIRQFAKFLQNELSDYLENEDKKEPKNLSNTDRYAVYKVGPALVINHGIGIPSLMVIMHETLKLLYHADAKDVTFFRIGTSGGLGLTPGTVVLTKSSMNALLEPYHEQIILGEVVKFPATLDDDLRKQLIECGKDTGIPMAEGHTMCTNDFYEGQGRLDGAFCDYTLEDKLIFLDKVHKAGVRNIEMESVCFAAMCNRAGVKAAILCVTLLDRLKGDQVHLKPEDHEDFQARPPKIVAGYIKKYLEEQAKSSSFLRNGNKRAKANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKU3</accession>
    <name>A0A6P8HKU3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553225.1">
        <property type="nucleotide sequence ID" value="XM_031697365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKU3"/>
    <dbReference type="FunCoup" id="A0A6P8HKU3">
        <property type="interactions" value="1182"/>
    </dbReference>
    <dbReference type="GeneID" id="116290355"/>
    <dbReference type="KEGG" id="aten:116290355"/>
    <dbReference type="InParanoid" id="A0A6P8HKU3"/>
    <dbReference type="OrthoDB" id="10012356at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023611">
        <property type="entry name" value="mS23_dom_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019520">
        <property type="entry name" value="Ribosomal_mS23_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15925:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10484">
        <property type="entry name" value="MRP-S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS23 conserved" evidence="8">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553225.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19615" checksum="FED3B9E4830D5AB0" modified="2020-12-02" version="1">MAGARHLRGTIYTRVSNLLRSGAMKSKPVWFDVVEAFPPIVETKINRKPEPGRVMKLEYPEDYFRRKFYNTFKSYGTLDLHKGESPPTDCEMFVKKCHDFVSQGMEQEEAFECTTKDFMSETPTLKKQLLSEEENKRQASSGDSDSVTDIYEFLTSRDGPYKPKSNKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKU4</accession>
    <name>A0A6P8HKU4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BEACH domain-containing protein lvsF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555523.1">
        <property type="nucleotide sequence ID" value="XM_031699663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKU4"/>
    <dbReference type="GeneID" id="116292363"/>
    <dbReference type="KEGG" id="aten:116292363"/>
    <dbReference type="InParanoid" id="A0A6P8HKU4"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="1">
        <location>
            <begin position="192"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555523.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30635" checksum="A957F60A57CB430B" modified="2020-12-02" version="1">MADCLTFTSPSGLEPHKTKERKERFSLLLLEPGEIYFEDFSVFYYPYNVPEEEAIKRRQRGRLKMCSKSILFDPIDTSFPILKFPLRECLRIAHWTGPLLSKIDTKGDVLVIESKQVIEMKEGNIVAPYRFIREKKKYLFSFNFVALGFVLPQLEQLNRASTLTPADQLTMVNTIVQSRQSKVTFNTSWLEDFYEKIVIETSAKRITPLVCNPGRVMLTCSRLYFQPFNNADPCPVVKCKLSQISRVVKRRYLLRHVGVEIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLB2</accession>
    <name>A0A6P8HLB2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable serine/threonine-protein kinase DDB_G0280717</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553462.1">
        <property type="nucleotide sequence ID" value="XM_031697602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLB2"/>
    <dbReference type="GeneID" id="116290546"/>
    <dbReference type="KEGG" id="aten:116290546"/>
    <dbReference type="InParanoid" id="A0A6P8HLB2"/>
    <dbReference type="OrthoDB" id="5965268at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="83"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553462.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37350" checksum="832EAC7CED6A070F" modified="2020-12-02" version="1">MNHKNRRKAKRQRWLQRKREKEAEERRKDRERRIEERAEQLIAMRANDSKVLEEPHAPEPPKKKLRLPTKDVAVKEINSNHIVRTKKHLGSGSYGSCFLAFYRGITVVVKELQIHSSDQETKEDAKKRTHNELLNEANIITKLGDHPGLPLLFGICSKSTPYRLVLQFHGNGCDSLTLLRALHSKLVAKKREWDAIMIKTAEALQHIHSVGFLHNDLKSNNVLLDKRGTVLTPVIIDFGKSRPISNPMGPKTLSLEEQVRYKKKYPHIAPEIVEGRAGQSVASDIFSFAKIVEQIYLKCKFEELPHLVTLCLSPSVEARPRCAELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLB3</accession>
    <name>A0A6P8HLB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myeloid differentiation primary response protein MyD88-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555728.1">
        <property type="nucleotide sequence ID" value="XM_031699868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLB3"/>
    <dbReference type="FunCoup" id="A0A6P8HLB3">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="GeneID" id="116292526"/>
    <dbReference type="KEGG" id="aten:116292526"/>
    <dbReference type="InParanoid" id="A0A6P8HLB3"/>
    <dbReference type="OrthoDB" id="10037120at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070976">
        <property type="term" value="F:TIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002755">
        <property type="term" value="P:MyD88-dependent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017281">
        <property type="entry name" value="Myelin_different_resp_MyD88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079">
        <property type="entry name" value="MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079:SF3">
        <property type="entry name" value="MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="4">
        <location>
            <begin position="140"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555728.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32283" checksum="9CC6C0F90D6DA77A" modified="2020-12-02" version="1">MASSEETNHVYPTAPLEEEKLVRHMSYEALLRLSQLLRPHHELGNNYTALAGQLGFTFEEITDLREERDPVHVMLNKPELRDLTISRLKSCLMAIDRLDALQELETFEEKTLYPSEYRQRQAERHGRNNDQQFTVLSNDEKYDAFICYARQDIGFAKEILKRLESEPYHLKLCIDYRDILPGGGNLSTVAHIIEERCQKIVVILSEFFNNDESADFQAKIALSLSPGCKNKRLIPIKYEQCKIPTIYRFITHLDYTNENAREYLWPNLARALGYAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLY0</accession>
    <name>A0A6P8HLY0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Interferon-induced protein 44-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555973.1">
        <property type="nucleotide sequence ID" value="XM_031700113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLY0"/>
    <dbReference type="FunCoup" id="A0A6P8HLY0">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="GeneID" id="116292762"/>
    <dbReference type="KEGG" id="aten:116292762"/>
    <dbReference type="InParanoid" id="A0A6P8HLY0"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555973.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39802" checksum="9E09415FB60DD54F" modified="2020-12-02" version="1">MDENLRQSLVGHDLKLLHCRFRFPSKLLQEVCNIKPLTSNTLSISDFRLLLIGEVGSGKSSFFNTINSIFRGYVTSQAVTGHNADHSVTTMFRTYDVMSSPLGKPFKWKICDTAGLLPKDGLTVAELLYLVDGNIPNRFRFNPYERITPDSPGFIESPSHSQRAHCVTLVIDSSTVDKMPESMWQKYQLLQDALNARRIPLVVLLTKIDLACTQTRENLLHVFHSQRIQNTVRMISKKFQGLPTNKIFPIKNYEWETDLNTHVNSLSLLALRQMLRFAQDHIEEKADQFDPGVIRKYLNFRQPFFIIFVVVLFVLILVLFFFSDKVMEMLAFSGSGSHEGEENDDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMR4</accession>
    <name>A0A6P8HMR4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inactive pancreatic lipase-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553932.1">
        <property type="nucleotide sequence ID" value="XM_031698072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMR4"/>
    <dbReference type="FunCoup" id="A0A6P8HMR4">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="GeneID" id="116290947"/>
    <dbReference type="KEGG" id="aten:116290947"/>
    <dbReference type="InParanoid" id="A0A6P8HMR4"/>
    <dbReference type="OrthoDB" id="6019621at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028235402" evidence="7">
        <location>
            <begin position="22"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553932.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="50232" checksum="3FDFF11CDE6E718B" modified="2020-12-02" version="1">MMNQILTFLILALFTFSNAGALKKCYVKYGCFSKDPPFHNPLVALPQSPSQVGTSFQLFSANDPTNMKIIDDSDVTKLQASGYDGSKDTIMVIHGWTEKVDKSEWLQSITPALLALNDKNIIIVEWEEGAAEFYTQAAGNTRLVGAQVAEMIKFINHQTGNSPASFYVIGFSLGAHVAGYAGRRIQQPAKIGRITGLDPASVFFIDTDPAVRLDPTDAAFVDVIHTSIGSLGTSTVSGHIDFYPNAGTRQRGCEIPRVGITTSVCSHVRAPKLLIESITSQCPFRAYPCAGGWNEFTRGNCQTCPSSGCPEMGFKAINSKGKASGKYYLFTNDEEPFSCGIRRIVKVSFETLGGWLSSGGKDPGMRVYGSNGKNTGIIRLGNRDIKKGSTERFIAPFKELETLTSIDVWQYQDLSIGWSLKKVLIEFTDTNEKYSACYNTRVYRIAVKRTLRKGDQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN19</accession>
    <name>A0A6P8HN19_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554055.1">
        <property type="nucleotide sequence ID" value="XM_031698195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HN19"/>
    <dbReference type="GeneID" id="116291077"/>
    <dbReference type="KEGG" id="aten:116291077"/>
    <dbReference type="InParanoid" id="A0A6P8HN19"/>
    <dbReference type="OrthoDB" id="10057979at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554055.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27475" checksum="54353203D0A4FE8C" modified="2020-12-02" version="1">MHVWWPGLDEDISQVVRGCSKCQLSRNKPPQAPLHPWDWPNNPWQRIHLDFAGPFIGKMFLIVVDSHSKWLEVEIMSSTVSEVTIDRLRDMFARFGLPKQLVSDNGPQFMSQEFAEFTKRNGIKHPCRTLPSEIERTGRTAEGNGSIKQKLAQFLFSYRNTPNSTTGQTPAELMLKRRPRTRLDLLRPHLGNKMEAKQAEQKSKSMTNNSKEREFPIGEPVFKIFEENPNGSELLSQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN65</accession>
    <name>A0A6P8HN65_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase MIB2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556428.1">
        <property type="nucleotide sequence ID" value="XM_031700568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293174"/>
    <dbReference type="KEGG" id="aten:116293174"/>
    <dbReference type="InParanoid" id="A0A6P8HN65"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031556428.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16848" checksum="E2F757F820AEA1C1" modified="2020-12-02" version="1">MTGIVIMDHHMNDDIPVGKVLVEWGGQSAINIEHRLGFDGKVDLKLERSVPDIYYYRDHLMIPRIXVRTDERXQVKDKVTVHLDLDDLHQMIKAKYDGHWDADMERGITEEGIVEYIDENGVEVKFKALKETLLFPHECLSKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN97</accession>
    <name>A0A6P8HN97_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD repeat and FYVE domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116293207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031556468.1">
        <property type="nucleotide sequence ID" value="XM_031700608.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HN97">
        <property type="interactions" value="2378"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116293207"/>
    <dbReference type="InParanoid" id="A0A6P8HN97"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="11">
        <location>
            <begin position="2789"/>
            <end position="2916"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="2944"/>
            <end position="3237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3384"/>
            <end position="3425"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="3718"/>
            <end position="3778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="963"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1295"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2756"/>
            <end position="2775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3516"/>
            <end position="3625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1266"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1304"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2762"/>
            <end position="2775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3530"/>
            <end position="3544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3572"/>
            <end position="3594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3616"/>
            <end position="3625"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="13">
        <location>
            <position position="3567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556468.1"/>
        </source>
    </evidence>
    <sequence length="3786" mass="425122" checksum="12A7CAFECEC02302" modified="2020-12-02" version="1">MNLVRKLVGIRTRPGSDLVSQSNQDDELCLRHLRKLFMEFRHSPTPMTVKDQENALFRMLPLFCKIFSNANPSALTEKFGDVCQFAAHVSQLMVREIRKRASNRNHEVASKAVMDFLLSDSVEETGSGWKLLASLNILAGGETPVLECMVAANLPSTMVKCLWLFYELPSVKEINEKSIEDQLQDLEIVQKVYTQILVKLCHSPATSNELVNTDDLSILFSAISCPCTKKHNIGWRSCVSEILMTVTRYGLNKEVINYIHGKSCVSNCLENMKRIQRVNPLELVEMMVTFVCCLKDSSEISHLLLADFRSCGGYLFLYELLLILAEIESEDAREASRNVALLVSSLVMVGHINIQPLISIGTPFQDPSFVIPEPSGGGVSVKNVEAFHVLQKVFLKTSDKLLCLNILDCISNIYRSDNANYFILEPQHTISLFIDSIPDKETQVQEKVFKLLDFVICNLNWVPCPELMSVSILFKNRGPCDCHQVALSFLIRILSFNPKYXDIFREVGILEVLTNCLKDYAAVLKENDETFKQPSTPNEDLNKTEEDQEEVFVTESTPNDYPFLLMGCLRLLLESNAENAKVFRECGGARCAHNMIPYSKSRTDALRIIHELILNGGSDDLGTLLGLMHSTPHSEVQLKIEVLNALLKVFELDPRTRAVFREVGGFVYVMSVPLNMEGSLKTPAATPWDKVDQEEVLTLLRTVFHVLTAAMQDEPANKNFFMDEVRFRGLADTIRLLGCFSFSDLEMXPYTGEVKPYLRGFKKMLSMSSNHLPLSPTPSTDSTRSSINQDGPSEPDLSPTSLLYAANEMFKNLFEMATDSFGLMAGNYGPTDMMNGQSVSHYGSXVLSVYHPGAITAVVDLLPAVCELQDNQIVSNNEDCLELQMYWLSKLQQLLRSEHNQQVMCDVGLPQQLLQRCEAAFVDEDHPXNAPLQRMFERLASQGLSATVLRDFLRLGDPLLCKPLKPPEEEPSLTQESKPDGSELVQENAVVENKATQENESTVLEQMDQATPNGIRKLSDVITRKISDSSSRGRVDSRSERGTLDNRCSNLSFHDVMMSMIQPSPDSSFGEESDSDDEDRGFEMLGDSVEETTDDKSKDDSKDSITEASPGIDGQTDSNTSPEEEVQPKRPPRPKRDQLHHRHNLFDENTMYGQTMPVTPGHSGATTVVDGVDIDTVGENQQQVSSIDQGDDLVIVDVTGDSGQTSTPLIDVPQHEENLHSDNAWNPELSESIDDSQTLGKELLPGSXNSSRRTSQSSINSFDSNTDVKTESQHKAAEMSVEDITQQLSLHCAQEPDLQPIPDETSRERSTSECHDTELEVEEEPVFPENKPVPLTRVKCLVSMTTPRDARAHGVSYCPSFVEFDMGVDGFGCLFMPAVAPQAFPGFSTVNSVVGNTVVAVGAVPGIGTGERLFPPQAGLTFTTWICVDRFSNAXEDPHPVRLLTIARQFRSSDGKVQNSPCLTLSISALDKTLVVRTEESAIDDDEGTSDQPRREKDKTEARFLSDLLLEEGRWHHVVVVLNKALIRNSTSTLFVDGQHVATSRLKYMQAGIVNPDPTTAAATPYIVAYIGTPSTHRRCSRLLWKLGPTHLLEEPLSSGTAMKMFMLGPNYVGSFQSPCLEGESAYAMENVEPLVSEDKVMFGVHAHAKSQLSMSKIRRHFRKVDTRAIARELGLSTHDNTTPVRLIHNTAAHLQGPSRTIGAVMIGCSGLRTFCPNPVTKLIECIGGVSCLLGIVAMATDVEALYASVKALSCVLRSNPSARRDMERTRSYQILALLLRKKKHLLNTHILHLTFALVGTVDSDRESSIIPNIVAFRELLCDLEVWHDAPGDLERSLYSHFLELLGPGNESQANAELMQRLGLVPKLLFVLQDENVTDSTANTIASVLSVLLSNVNEERNLLRFGQFLVSTVSSHYIDENEVNLDGDNVTESSGNEEVENNKEGLTPKRIRLRNVLLEVVLCLIYGEGGSLDHRFSDALQQTLGFDWLLLFLHPHIHKTTVVRATRILVTILGSQAALERFKEGVNNGGWLAGTEMILNKNTYVVAGFNVGAVSEGTEKYEVCKDVCNVPGFAMLSSLLPRHVDIPEIYHLIIALLLGHPVSDVYAGALFDWHNLYSVFWSSTSTGVKTSPPSPRDPAAYIIYCAEAATVLLSMARSMVNEAWENTEEGSWLREYPVTLIQFLVFLYRNVTQFTQVCTGQEFIENLVAVLFPKRRRLAAKSQEITSDSEGEGEISSELVFSEEKTQLITHPARKCILEFLRVIMTDNLTCTTSNKSLGVIDIILESYPPSCMQPQQAEYQTEVVSAQMDYFLGGNLLANPSAGHGNHAKIVANAFTFASKVVDKLWIGNFRLSYKVVFNFITSIMEAVKGQSVSMDGIYHSLNRTVLYQLSRPLARLTDQTSLLEFLHILTTNHKVVFAPGNNEAEFIAGVCHWLLVMGTQRRTNTESVPSTSTPIKEMDSLVFPPAFSVEKADEAEEHDTFNETADEESSCSRLLAAAAERVWDIFLLNKRDAIDETFKIELPKPSFTSYSXREYMDYMPMGSGSNLNLDLKSVRPLIGDLAMKAWVNFVTSEEKHKAEALGQQKPKRRTVPRLTARRAKKDTRDVNSLTKNSFLWTPKHIKVVKDWVRLQQKNHQQNYQLISKSIAEEWTLIERDLTRERGLWGPPDSSTLDKWTLDLVEGPHRMLKKMCRNEQFYVNYPYDYRSGNLKKQTRYKKAMSFDSKTYYMLRGPALPGVGPIEALLKNQVTDKYNKELPPRSLSTEQSYVTETNEGSEVDNQTIVKLLEAGEKIRSMYRCARVQGLDTAEGLFLFGQMHFYVVDGVTLLSTKEIKDIDSLPPGTHDPIIPRSSHDITKACTKQRMCSKWSYDDVREVHKRRYLLQQTALEVFSSDGRNHFLVFPKPVRNKVYEKFLATAPTLLVNAEDSISGMKRDTDVETGVGIINTLMGERSVTQRWERGEITNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYNSEELDLTNPKTFRDFSKPMGAQGKSRLEHIKKRYREWDDPTGETPPYHYGTHYSSAMIVASYLIRMEPFSQHFLRLQGGHFDLPDRLFHSIKDSWLSASETNIHDVKELIPEFFYLPEFLTNHNNFDLGTKQNGEPLGDVLLPTWAKDNPREFIRLHRKALECDYVSARLHEWIDLIFGYRQQGPGAIESHNVFHHLFYEGNVDIHGIDDQVKKTATIGFINNFGQTPKQLFRKPHPQKKVFRAVEPDLQTGLTSVINVDRLFFHNLPNLVPSAQPVKELKAPVGVIYQSERGILAVEKNKVLIPPNYNRYIAWAFGDLSMRIGYYDTEKIMNVYEHFHIGQVLCAACPDSRTLITGGTSTLVCVWDIVKAGSRDRKPQLLLHEVLYGHQSSVTCLAVSTCYQLIVSGSEDQTCIIWDLSKLTYVRQLSGHAAPITATAINELTGDITTCAGTYLYVWSVNGQLIVKDNTSLQTNNHIQCCAMSELSDWDEENVILTGSLDGVVRMWGIEFYNEAELKSPKPKKSVTGNSLPRKDTIPEEPSEKAQEIQTVDSKTPNPDPDPIPDIPKETPPIEENKSQDEQPQSDKESDPSKEIEDIGIVPTPEGGEERENMVRASKLSQTSQDSSTLDEEYVIIENEKQNQKEAKPKPVWRRRLTLRHKLTMHTSFVRDDNMAPAXVTALLISKDHRRLFVGDGRGRIYSWSVTDAAGRMPADHWIKDEGAESCTQCHVRFTFAERRHHCRDCGKLFCAKCSKYESSIQRLRIYKPVRVCKPCYDKLRKEQARGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNM0</accession>
    <name>A0A6P8HNM0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intraflagellar transport protein 56-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554217.1">
        <property type="nucleotide sequence ID" value="XM_031698357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNM0"/>
    <dbReference type="FunCoup" id="A0A6P8HNM0">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="GeneID" id="116291216"/>
    <dbReference type="KEGG" id="aten:116291216"/>
    <dbReference type="InParanoid" id="A0A6P8HNM0"/>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000588">
        <property type="entry name" value="Intraflagellar transport protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001530">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000271">
        <property type="entry name" value="Tetratricopeptide repeat domain 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554217.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="64180" checksum="C5EC8E606E87767B" modified="2020-12-02" version="1">MILSRTKPAMGPGSGTTVSSAKDTKKKRKLPKFEDFLQMRDFTGALTLLEFNRNSGKGNEEMSLWIAYCAFHLSDYKKAMEEYLALTKSEACHPDVWMNLAGCYFFLGMYQEAQSVSDKAPKSRLQNRLLFHLSHKFNDEKKLMGFHQNLQDIIEDQLSLASIHYLRSHYQEAIDIYKRILLDNRDYLALNVYVALCYYKLDYYDVSQEVLAVYLQHYPDSATAVNLKACNHFRLYNGKAAEAELKSLQENASPSFSFAADLIKHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVVEAYNLIKDLEPTTPQEYILKGVVNASLGQEQGSREHLKIAQQYFQLVGGSASECDTIPGRQCMAACFFLLKQFEDVLIYLNSIKSYFYNDDTFNFNYAQAKAAVGNYKEAEEIFLLIQSEKIKNDYTYLSWLARCYIMNHKARLAWELYLKMETSGESFSLLQLVANDCYKMGQFYYAAKAFDVLERLDPNPEYWEGKRGACVGIFQQIIAGHEPRETLRDVLQILRNTANPQVEYIIRTMKKWAKENRVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ59</accession>
    <name>A0A6P8HQ59_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Uncharacterized protein LOC116294289</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC116294289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NLRP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557716.1">
        <property type="nucleotide sequence ID" value="XM_031701856.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557717.1">
        <property type="nucleotide sequence ID" value="XM_031701857.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294289"/>
    <dbReference type="KEGG" id="aten:116294289"/>
    <dbReference type="OrthoDB" id="5951217at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="12">
        <location>
            <begin position="311"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="13">
        <location>
            <begin position="980"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="11">
        <location>
            <begin position="1443"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="10">
        <location>
            <begin position="1596"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="933"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557717.1"/>
        </source>
    </evidence>
    <sequence length="1685" mass="192873" checksum="6C1D12EEF0B78771" modified="2020-12-02" version="1">MAISWASSIKVNLNFARLSKLLIDGGTSALRDVFDSIHSPSSLHKTLLSTTVHSTLKGLREKRILNKQQWDRLYPASRSTTVTSADFDIKLLFVLLRNICGLTPPPTGWDKIPIATDLSREADLARVEYYRNELYGHITETAVSDSDFEKYWSEISDVLVRLGGPHNKPKIERIKIEEVDPEQEKNYIKALEEWEEQQRLIRKMEEILKTVKGDSAVDPSHVKDSEMLKEAIKGSTDYQTKFMAAHDVPSAKTDEIVTNLTVYYADKKQKKKGQAKDLGRSEQLQGYTKRTMSCKVDKYEDIFNDMQGENPNLLLTGEPWIGKTFLCEKVIRDWSINRLFKNENTPNIQFAYLLKLRQLSSKGDKKINLQELLNCSPLLDDNSVINDSLFEYLIQNPSKLLIILDGFDECSEQHRKQIASDYEGIYPNDSKEKMPIPVLCSKLIRGKLLRNSVVLVSSRPGEAEELGKINFDRYVEISGFSPEQVTEYVDKYFSEPGKERTKKTVREHIEKNENLMSFCHIPLLSFLFCWCLEWRISSSGIAENLPAKITDLYDEVVKVLVQKPHANLKYSEMSEYAMKIAEETLDKLAKLAANLLKESKYIFDEEDMKKLDLTEDEIENLKISGILHCVPGIRISXXQTKEEFSFTHLTLQEFLAASFFVKNGEIPEKEIASGQTFVFISGLLARKKYGEHLMNKLLQQITPKHYNDHVNQLLMLQCLYEYGEEELTKQSMHYLYDISVVYEHICFRQTTDFDLKYLLYLVDIIRSLKEEQHPESLVVDTLEITHSSLTSFGVGVVCRSLVRNSFITALELLHCSLDNKCVEILTDSLVNTGITHLGLFGNNITDEGVKSICSVLTQTKITYLDLGINSITDEGAESICRVIIKDNCHVERLDLWGNEEITVECKKRVEKLVEKHKPIVLVYLGISRSKVSATEKEESRREEEKQDTESISQYHSLAESAASPLVSNEMKSLTISNKQNQAIIEVTQEGGRFDISMYGALLEFPPNTVESSTQVVCKVCSRESIPSPEADPMETLVSHIVQLGPSSVELQQPVIVTMLHAGPGKKSGYEMIVKAFNDEERIWKEIEEFKDTSHIPKNYKAGNVIQVKISKLTTLAVISRLVTDTFEVTPTGCVVTSSVCNDVTVTFPEGAVDKTITGSMKVVLLPEMIFIFSGFKDIKFLKPVTIKFPHEGSTDDFPGRLRVLSQKGAVHPGKRWNEVKGNVKLEKKEEGFLELHVQHFCRLTVAEPISWWWRSQQQVFLGAFKENNDSLKLTIACASIFVNFEHEFIGLGYERLAVSTAAMRPGEMAYVQVEDGWDIQAEENVYVKFIEGGRYREELVYSINYDYFQIHATSNILYLCFYPTMEFVENDRIGRLAIDRRRLYPTVVSMGNDPPEEVMDIDPEPPMNENQSRFVAPTCLDRHIPPSDRPECINTVYKMTSNPRGIAYIININRFSXHPCHKMYGRLVEFLGSHLDVNSLSRLFPDLLFEVQYHSDLKQNEFLTRLQIFSKTTKFSLYDCLVVFIMSHGKENYIYASDGEEVRLQEIFDMFQNCQALQGKPKLFFIQACRGTAADDGVVHRDDPGEQAQIARPGLNDRRRPEEYDNLYGYSCYEGQNSYGWDDYGSAYVQSFVDVFREHSCKEHLLSLLERVKRKVRERERNQIPWINSTLRKLLYFYPGLFENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQZ7</accession>
    <name>A0A6P8HQZ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NPC intracellular cholesterol transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116294115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557508.1">
        <property type="nucleotide sequence ID" value="XM_031701648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQZ7"/>
    <dbReference type="GeneID" id="116294115"/>
    <dbReference type="KEGG" id="aten:116294115"/>
    <dbReference type="InParanoid" id="A0A6P8HQZ7"/>
    <dbReference type="OrthoDB" id="5965801at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028095104" evidence="4">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031557508.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17804" checksum="8346EAB38A4301F9" modified="2020-12-02" version="1">MLMMRRACDFVVLAVVLAVSSTEAKIIEFGSCGPLIRPIIGKVLQLDITPCDSEPCVFHVGANVTAKITFIPEETVQDGLLEVVALFSTGERLPWPLKNPLACEDHNLNCPLKPKEPATAIIQARIEKIPGSYKIVAQVYMAETVLQNYVFCFRIPLQVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT30</accession>
    <name>A0A6P8HT30_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116294849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031558378.1">
        <property type="nucleotide sequence ID" value="XM_031702518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT30"/>
    <dbReference type="FunCoup" id="A0A6P8HT30">
        <property type="interactions" value="1576"/>
    </dbReference>
    <dbReference type="GeneID" id="116294849"/>
    <dbReference type="KEGG" id="aten:116294849"/>
    <dbReference type="InParanoid" id="A0A6P8HT30"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="1"/>
            <end position="95"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="1"/>
            <end position="13"/>
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        <location>
            <begin position="14"/>
            <end position="32"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363130"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558378.1"/>
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    <sequence length="285" mass="32126" checksum="122C00A233C3201A" modified="2020-12-02" version="1">MGASSSTLTSSENQQTPETPSPPSSATQTQTSGCPVQHGGNQQLGEWKSECPASAATASMGGGCPMKKTDDIDPLNMMPPANQQPSPGQPYPLPTDRVVSSIPKGNSDGEKWVYPSPQMFWNAMVRKGWKWEKDDLKPNDMDHIIRIHNANNERAWDEILRWEALHVKECGNPKLLSFRGKAKEFSPRARIRSWLGYELPFDRHDWIIDRCGKQVRYIIDYYDIGDEESYKQGEFVHLDVRPAFDSPSAILDRMRVAVLRWSMYFSSSKTESGENSPSDKTVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT76</accession>
    <name>A0A6P8HT76_ACTTE</name>
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        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555880.1">
        <property type="nucleotide sequence ID" value="XM_031700020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT76"/>
    <dbReference type="GeneID" id="116292668"/>
    <dbReference type="KEGG" id="aten:116292668"/>
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    <dbReference type="OrthoDB" id="5952548at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="473"/>
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        <location>
            <begin position="87"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555880.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55298" checksum="43E7EF0A20D1DB30" modified="2020-12-02" version="1">MPKFRNMSLSFISAYDLGQQSVAKCSKVDSLFKTIQYHNRTVKADMKNVVVKCNEDIPCRCSSKPSCVAVRLKSRENEQDSCWSWVICFCAAISNIIVIGLSYSYGILFPVLLEYFKMDRATTAWVGSTFSATTFLCGPVAANLCNRYGCRLTAISGAVLCVLGLLLTSQAPSIYTMFISFSLVVGFGCCCVYTACFVIVPRVFQKRRSLAVGMISLGPGGGVMVMAPTMQFLVDGFGWRKTFLVLAGITGFTSLLCCAFDSKTLKEVGESNVSLNQIEVSGDGFDTSIFRNKRYNVLLVTSFILFLGLHNVQVYLVEFSGTLNISANDASILYFYIGVFSTISRSSSGYICDIIPINPVFFVFTGTTIAGSSIILLSHTTSYIQLVIFSVFYGFSEGLLCVVLGILLLNSVSRRQRSLAYGVFLSLTAVPFAASPPFIGFLVDTFGTYSPGFCFSGISVIVSGFCALLLLFFDTTNNRPERVDTTSTSADICVEYKPMVEKMTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUH9</accession>
    <name>A0A6P8HUH9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sphingosine 1-phosphate receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295405</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
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    <dbReference type="RefSeq" id="XP_031559061.1">
        <property type="nucleotide sequence ID" value="XM_031703201.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aten:116295405"/>
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    <dbReference type="OrthoDB" id="10011551at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="44"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559061.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39574" checksum="5F6B135303082B78" modified="2020-12-02" version="1">MNSTINSTARFPTLNVSNTSNVYRSLTIAQMIIYAVLGVFILVGNALCLAVFLKTKKLRKRSYYLLISLSVADLMVGLSASVICVEDGLSLFHGTKNVLFAFWRDVTQYFPRMCSLFTIATVALERFWAVGFPTKHRSAGTRPYVALIALPWILAVASTVLFISSGRRFVSEHAFNFVDVALSQATLLTIIIAYCGLLKKMRSNSIRSNKPQINAIRERKLAVTLFVVTLASLLTIYPVNIYFLFEIFCKNFNTTSSKHHLIFLIALASSNSGINIVVYLFRIPEFKRAVFRLVPWKKRRSSRVACSSQINDAAGSEHPETIQQETQFNDGSFEPKLKPDRTPSKYLFKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVH8</accession>
    <name>A0A6P8HVH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Carboxypeptidase B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116293325</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556602.1">
        <property type="nucleotide sequence ID" value="XM_031700742.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HVH8">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="GeneID" id="116293325"/>
    <dbReference type="KEGG" id="aten:116293325"/>
    <dbReference type="InParanoid" id="A0A6P8HVH8"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000056">
        <property type="entry name" value="Zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027748445" evidence="15">
        <location>
            <begin position="17"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="112"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031556602.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45545" checksum="04EDD342BB0D19F6" modified="2020-12-02" version="1">MKFLCLLVLFALGAYAGPMGXVIRVTPSSKAQLNFLSNLADNDNMDLDFWXHPSRVGGSVDIRVTTSNYPNLAKLLQLNGIVFTILIPDVDVAEANQNPPSSARAGSFDYNRYNPLDQIVAEMQRLVQTRPNIASMFSVGTSYQGRQMSAIKLSSGADKKTLFMNCGIHAREWITPATCMYMLNQIITKYGSDSSITAMLNKLDVVIMPVLNVDGYVYTWTSNRMWRKTRSPQGSGCFGADPNRNFNVKWGGTGTSSNPCSDIFHGPRPFSEVESRNVARYLHRIRSKLVGYMDIHAYSQLWMTPWGHAKGAYPPTYQEMMRVANKAVRALYAVHRTSYRAGTSADIIYATTGGTMDWVTSRLGVTYSYGLELRDKGRYGFLLPANQIRPTGEETFAAIKVMVQEMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWJ2</accession>
    <name>A0A6P8HWJ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">POTE ankyrin domain family member J-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116293708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557030.1">
        <property type="nucleotide sequence ID" value="XM_031701170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293708"/>
    <dbReference type="KEGG" id="aten:116293708"/>
    <dbReference type="InParanoid" id="A0A6P8HWJ2"/>
    <dbReference type="OrthoDB" id="5971700at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031557030.1"/>
        </source>
    </evidence>
    <sequence length="1270" mass="141161" checksum="421A83C4D2AFEF82" modified="2020-12-02" version="1">MNFLSYWDIFGVVLITLYFILSWLYPKRTQQKSEVKAEKEEFSETHEGEDLEAERDKDGVISEPFIRGKSDIPEFVWNTSVRSSLSYGDAHHAESTPQEVNSSSCKIDPSSVENTEKLESSSLVSDLSLPSFESTNTAKGSVQSMQNSGHASNSPNDELLNDTSSKFSELILLPEDISLSLAEVPETENKERVGNVVDLKGDEKDVSKPVEFEEVPSNSYMECNRNLEDGAEGLSPIDVGIAASVVSDFSDNLNRSSGENTASRDIQTVEITSCNAEEISRQVPAEAMDAIDLQSPSPSKQQGKDLEKFANDLANTTIETAVDNSISLNTFAESLSEKIFSDSADDVILKVQTSLERQKIEAKMQKRLEIEEMEALGTCVASEVVNEAVGEAALKKEYMDNNELDVTSAQEIQPHIGFVVENVVNSAICEAASKLKRGDVDQPTEPIAEEETSGLHDKSNETETNNNVEAVCDSVILPVEEPLKDEAVEVVAEEDVKLESEIPLDIDKTLIEDLPVETSSKEVSEEAEKSVEDQSEQLIVTDDEQKIDKQVEDVEEQFEENVSELSAKSFTEYAATENDRETAEDEKTNEELPVENIPKLNELIDAEIKDETAISDSSEAKDEPKNHQITAEDAKTDEETPVEGITTLQKTIVPETKDETAISDSSKTRDKPELEQDILPTVDLDNNFEIPKDNLDEPLNKHEDLAPVIPEVRLTLDKEKSNETEVETSPSSSPGLVIQNQVTLRNKDQQSSDNKEGFWRRSLILDLEEDLEFEDSISSESYDVSSPELSKGKKEVTPHSEDSGDFTDSEEDEVIDHDAEARLGAVGGSSKLANDEAHYEDFDWYDYEKDSDEEDDGIKVFEPVLTVDGLCASRQVGKEKPKLKSVGSHYNRAVVLDNGSGIIKLGYAGDRVPRVIQQNVTGMPQRFSMHITGMESNLKDYKKYGSEAVAKAGVMHLTHPMKAGLIENWTDIEEIWEYLLYDELGAEVGDNPVLVTEVSQNPKKNREKIAEILFEHLNVPAMFLADQLPLSLYASGFTSGVCLSSGYSCTQAGVVYEGHTLAYTEQQLDIGGGDLTENLKILLXDIRARNFTTSSGWQIVNDIKENLAFVAKDYDHDVDKYQKNDSLTQYYKLPDGQMVDIGYECMSCVEPLFQPDTLMSANSTTASQQPVHKLIDTAIKRCDPELQDLCYKHIVLSGGTTLLKGFTSRLQHELHRTNPRIHKIRAPEHRRHSPWIGGSILASLSIFDEQYVTVDDYSEIGSQVIHMKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWR2</accession>
    <name>A0A6P8HWR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 12 member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557100.1">
        <property type="nucleotide sequence ID" value="XM_031701240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWR2"/>
    <dbReference type="GeneID" id="116293773"/>
    <dbReference type="KEGG" id="aten:116293773"/>
    <dbReference type="InParanoid" id="A0A6P8HWR2"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="6">
        <location>
            <begin position="178"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557100.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43121" checksum="B04AF9EFE233ECEB" modified="2020-12-02" version="1">VNWGSSGQANTYMTALRLTNMLDNQAEHVKNFRPQFLVLTGHPSKHLALMTIVSQMSKNVGLMMYGNVYVGNGDVPEEDAIEEKKWLREHKIKAFRAATTAQNLRAGAQAMFNLSGLGKLRPNTVVLGYMENWRSESKDLASYFGIINDAFDFSYGLCILRMGDRELDIEDGISSDSETEAENQNQKKDVEKGVKQPLKAAPEPLSSEITFKEKQKGTIDVWWLYDDGGLTVLLPYLLTQHRLWGGCKLRLFSLDIRSKHTIKATELKMANLMKKFRITVSSVEQVSGANTNPSKKSLEAFKMLAGEEELEGGEVIDQKVLRTIRVGELVRERSKDANLVVISLPIPVAEVTTPNLYMSMLEALSADLPPVLLIRGNQSSVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWZ5</accession>
    <name>A0A6P8HWZ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase TRIM56-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557102.1">
        <property type="nucleotide sequence ID" value="XM_031701242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWZ5"/>
    <dbReference type="FunCoup" id="A0A6P8HWZ5">
        <property type="interactions" value="1708"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_BBOX"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="279"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557102.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31813" checksum="2A1DB68B21835B39" modified="2020-12-02" version="1">MAAIESLEDIIDTLEEQLTCSLCHDVLTQPKTLSCLHSYCARCIAPDLYQSGNRMDCPFCNTTVVVPDGDPSKLPSSFYLDSLLDLLHAMKSIANEPVLPHCVSCEQPRVLVAFCQQCNGLICEACCNAHRLFREIRDEHQPIMLDPFREGDVNSFIKTQMLCKCHERKKLEYYCQEETCRLSVCQKCATLNHLNHQLKSLEDAGQDSRNLIEGAVNRVEQRKQNDGQELKQSKENIERIQREIDVAKKDVQNVVKMICKMAKEHGIAKEEELNQTLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX27</accession>
    <name>A0A6P8HX27_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Receptor-type tyrosine-protein phosphatase F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116296052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559866.1">
        <property type="nucleotide sequence ID" value="XM_031704006.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:cytokine receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
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        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF151">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031559866.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20162" checksum="29E9E9BC192C8593" modified="2020-12-02" version="1">MKVTWSSIPEDQRNGIIRGYKIYYKELLYPRNKWKVSVVTGGDVSSTMVTGLKSYTEYCVKMSAFTSKGEYRDXGRKQCKIVKIPSLPIKVQAKAMSMTEVLLKFVKPVHSFPSNKVQVDYGTLKNELNMKKACYGSSCVIDNLEPDTMYYFRVIGYVYQRGETSTLTKIKTSRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXC9</accession>
    <name>A0A6P8HXC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">DNA repair and recombination protein RAD54B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116293959</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557319.1">
        <property type="nucleotide sequence ID" value="XM_031701459.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557320.1">
        <property type="nucleotide sequence ID" value="XM_031701460.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="317"/>
            <end position="484"/>
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            <begin position="214"/>
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            <end position="50"/>
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            <end position="226"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYM8</accession>
    <name>A0A6P8HYM8_ACTTE</name>
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        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC116294318</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116294318</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031701905.1"/>
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    <dbReference type="KEGG" id="aten:116294318"/>
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        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="10"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
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        </source>
    </evidence>
    <sequence length="2207" mass="245988" checksum="80ED5368EFAE8D1A" modified="2020-12-02" version="1">MKFTDLNSEPEAMPMLPTGKIITSAGSTTFLMHKAAKEGCLDVLQRCIDENKMAACMMDDKDFSPLHYAAQYNQTSVLTALIKAGVDVNIRGDGDITALHIAARYDSLEATEFLLSNGANTSIRCAVTGSTPLLVAVRMENPRIVTSLLSKNRGLVDDHDLQGMTALHLACMRGSIEICKILFQYGAHTSLSKRNEDGSTPIVFAAGSNDEGILSLLIDEAKKHNANMKELINGSEEDSTTPLLAAINAGNEKNVRLLTENAASVNTPGRKQCTPLHVAAMNGNVDIVKILLQKGANVDAQDAQGKAPLHRAASLGWLEVIRVLTHNKATLELKDEDGMTPLLCAILSGQVFAVKLLVSLGADVMARDNDRRTSLHIATINEHFLIMHVLLKGEKDLQNIPDQLERIPLHYAASGEDTRIPTTLIEHGSNCHFKDRGQATPLHVAAEKGTLEHVELILKAAPCSIHERDLHGNTALHLAALNRKRETCKILLRYGADVDSLDFQLQTPLFRASQSGSLPIIELLLEHHANPNHKDIVGNTALHIAAEYGNPTIAKAFLDKGVECSLNNQGSSCLDTAIASRASEVINTIVKHQRWEELIHVDRGGCAIMAKLISDFPEGASLVMDKCIRRSNHKPSDPDFSITFDFQLLDPGPDRQINPDVPTDKAFPQVLVRKESDGKRFFGLLEMVNHKRQELLVHPLASRLRRVKWKSFGALVYCFNFIMYALFAMLLTLFMLNVRGGLQLARGRKNLEGGCSAVTTNQQIVASFAFVISVLHFCKEIFQMYIQRLRYFTDGQNLFEICMYVFGLVFLVPYTFPGSTGLCTGRQGVIWRFGTVTIFMAYFNLILLTRNLSFIGLYVTMFIEVFKTLMKVMVMGMLFLLAFALVFYILFKEQDAFDGFGEALVKVMAMTIGELDYNTLLVDAENQNNTVTGAPLVPYPELSYIFVFFFIMTMPIVLMNLLVGLAVGDIEAIQNKAFLTRIGRHVEFLTDIEKQYPKMLLRWLYTPTLVIFPRRTHKSFWKLYVGKSLERFIEDDVDKQYDTDPIEEKFNDLKDEMSLMRDRMKIMMQSIEHQNQMLRSTVVTSRSSIAEDKEATTFVTREVRSVAMEENLSTESISLVAVSPRQAYELRNVDPGIPSRLQNEEKKDNTPRCILMAALHHHKDELNRIRNSEEGAIDMKDECGCSALHYAARHNDAHVISTLLDAGADINLKGPAGQTALHISARFNCVESTKVLLDNNADTTIPCDINSVPLHAASRYGYQEIVKLLLQSDPSVVNCKSTGCVTPLLLASLNREKTVCELLTEHKADITVVNVENKTPLHVAAAHGNIEVVKFLIDKASKQVPDIKDFIDKTDYEGNTALILASYGGHDEVVKELLQNGADPLIQKTSSKITALHVAAIGGNTAVMEYLLSYGAKIEALDSSYMTPLHGAAASNQASALKFLLDKGAKVDALNISGLTAFLFSVKQGNKQAAAALLEGGANIKATDMRLRTCFHYAIKFNALNVLEMLIEKDDGTLLEMKDGGLQTPLHYAAASGNMKIISLLLRNGSYLRARDADEATPLHIAASFGCVEATDLLARMSPKSINERDIRGRTPLHCAVQGGFRKTCAVLLDLCAMPTIRDLNRRTPLHVAAESRKLNCVKALLANPDTRILELLDIDENSALHLACRKGAVDIMKELLDANADVTVRNKEGKTCLDVAVDWELEDVAAALVQHPRWMEMLRIQGPDGHRPMKRLIEFLPSVAEIALNQCLEVSDFPSTHPQHSIKFDLVLLDPGPDDELSLRGEPFDGPATMVRYNREELLNHPVTQALLRYKWFAFGKVLYYLNFAVYLLFTILFSYFIIEERGRLSLFSPSTVNASSAEKDHLDVYPSSSTMSLAIVIAFFLCVQLLKEFYQLVMLRLSYLRESSNLIEVFLYTTTLIYIAPYLASKPMYYSPAVQWNAGVVALFLCYTDLLLYIRRIGNSGIYVSMYFEVLITFLNVLVVLIVVIFGSAVIFYVLMKEQDNFSSVPLSFVRTSVMMIGELDYTDMLSDNVVNKRTNPNTGAPYVPLPDITYTLFYLFMLIVPVLLMNLLVGLAVGDIDAIQKTASFSRLKDQAKFVEDTQKRYPRKLRRMLYRDELVIYPNSNRFFKSMLLAGTSIIDTEYIEKLCKLKSTDGGDDAKGNQEALRYERQKTKLRVLEEKVDQQNKLLMAIGQKLGINDMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYT4</accession>
    <name>A0A6P8HYT4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296647</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560558.1">
        <property type="nucleotide sequence ID" value="XM_031704698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296647"/>
    <dbReference type="KEGG" id="aten:116296647"/>
    <dbReference type="InParanoid" id="A0A6P8HYT4"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560558.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21579" checksum="AE03E821236A5F6F" modified="2020-12-02" version="1">MAQHMMLLAKQCSLLTIVNQVLNNELKKTKRKINDLEIXVISRSRYVWTILDFPTQAKKYTQGTWMRSPTFWLCGSCWFLKLYPNGRDKXSKEYVSLCLVLSDEDILVRTGKPFIVATNEVTVAYARITVKSQSQATSITHDVTLNPKFESTGVVREVAVISELMKANEARSPDFCSVKDGCFTVTCILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZW3</accession>
    <name>A0A6P8HZW3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leydig cell tumor 10 kDa protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561909.1">
        <property type="nucleotide sequence ID" value="XM_031706049.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HZW3">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="GeneID" id="116297761"/>
    <dbReference type="KEGG" id="aten:116297761"/>
    <dbReference type="InParanoid" id="A0A6P8HZW3"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561909.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10093" checksum="57D895506EAA667C" modified="2020-12-02" version="1">MAQGQIKKKGGKKPQKNSSKKASGPRKGAKSIAPKKKRHIKAAMLKKSLQKAINSKIEHELAGHAVTKGSKPLAMIKVDEQDKXESKTKGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I030</accession>
    <name>A0A6P8I030_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Elongation factor sec</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Eukaryotic elongation factor, selenocysteine-tRNA-specific</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116294712</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons. Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558217.1">
        <property type="nucleotide sequence ID" value="XM_031702357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I030"/>
    <dbReference type="FunCoup" id="A0A6P8I030">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="GeneID" id="116294712"/>
    <dbReference type="KEGG" id="aten:116294712"/>
    <dbReference type="InParanoid" id="A0A6P8I030"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01889">
        <property type="entry name" value="SelB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000900">
        <property type="entry name" value="Eukaryotic elongation factor, selenocysteine-tRNA-specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000052">
        <property type="entry name" value="Selenocysteine-specific elongation factor EF-Sec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="19">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031558217.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="64525" checksum="F10390C1D713C75B" modified="2020-12-02" version="1">MADKTPAKKVLNFNVGVLGHVDSGKTALARALSTTASTASFDKNPQSKERGITLDLGFSAFQVPFPQHLKSDSKDNESSYDFLQFTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGIQTQTAECLVIGEILCEKMVVVLNKVDLLKEDKRESLIEKMKKRINKILDTTPFAKSPIISVAAKPGGQEDTETESIGIIQLVEMLTSMTYIPQRTSSGSLLFAVDHCFSIRGQGTVMTGTVLNGSISLNDTIEIPSLKITKKVKSMQMFKQSIKCATQGDRVGVCVTQFDPKLLERGLVCSPSSVPLVFGGIVSAKKIGYYKSAITAKSKFHITVGHETVMGRIQVFGLPKGESPGEDGFSLDREYIYQEELVNLSKSQNETENKEESVKTTSSAGDDLSDHQWLIIEFEKPVVCPENSLLIGSRLDTDIHLNMCRIAFHGKLLLPFTDKDYADTVLPQLKVFKIKHREGIVERIVDDYTVIGRSLFKKETNISTFTGMKVSLSIGEEGVIEGGFGQSGKVKVRIPAGLKKETIQQLQASGKKKNTKGKAVESSSSTSGESTGSKEAIKIILKFRRYIHDKKKRMIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I197</accession>
    <name>A0A6P8I197_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger CCCH domain-containing protein 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558650.1">
        <property type="nucleotide sequence ID" value="XM_031702790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I197"/>
    <dbReference type="FunCoup" id="A0A6P8I197">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="GeneID" id="116295074"/>
    <dbReference type="KEGG" id="aten:116295074"/>
    <dbReference type="InParanoid" id="A0A6P8I197"/>
    <dbReference type="OrthoDB" id="5980452at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032053">
        <property type="term" value="P:ciliary basal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903723">
        <property type="term" value="P:negative regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033207">
        <property type="entry name" value="CCP110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594:SF1">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16025">
        <property type="entry name" value="CaM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558650.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="97060" checksum="1A53E3A223198AEF" modified="2020-12-02" version="1">MEIQNCLQELLHDDNTEENGVQLNYFDLIASKSQESLLCFEGIKILPPLLSEVEKNEMRDYRRKAVDLEQKHFEARRQKYSNLLLKVMDIMDRCQRKGGKNRTKTPIPEGNSSNDNKGKENVQAQEKIIISKTNNHHVAGESNNGSIEILQDNVRNYKSFPEERKRKEGSNQNVKDDLPDSSLIFQKPKLYNSSSSPRRNKVDESINSTNESDRTSQKLQNLSLDRESSASSTGTTIASNKLHGEHLDSKREITAGDSLASTVLSMAFTDSSVTTQLSTMEGIQQTVKPVQRKLNMDNVNQNPNHLYYQSMEPLTSTPNELQRPDTRSSQRAKKKAPVKHVASKKSTETYTEQDKALEKLEMMRKKLLEEKEKQVALLRQQELARLKKNKDNQKQFNLLQELNTQSDERDMYNDEQFNARPSSDMYSISERSFEGSLSLKGDDQNEAESASDKENNHYTYDPQHRMYHDMNSVVHYRQDTLENRSQAKQHGPFSPSPYVRQEFLKQFEMAMNQGCDGRDKFSILTAYSKGFLTRCLLKAEKVQAIIKTIKDTSEFLADISKEGTNSYQDKSLQQRVQAQLVAAKQKLYDIFFKIAVHDRMSYITHSRNVAKEREERQYDKSKKSARKLSSATLKAMQRRVVEQNENSDVKRASTHSPLGRRKNWDIRVLKPVQSTKSPQLQDKARLAGRRRPGTAPSPRHSIIKKNTYNNRPATAMTKQSNRKSISRRSVENDSASLRKPPRMSLEGKLQTTVKRTKANDEEKSSISKLPVKRSLTGGQTYRVTRGDEEDKKTQQQYSRPSRLSLEGNRQVRESSAKQNPVKSNIRPKTASGTRRVTRSMAAKFNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2L3</accession>
    <name>A0A6P8I2L3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116295471</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031559142.1">
        <property type="nucleotide sequence ID" value="XM_031703282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2L3"/>
    <dbReference type="FunCoup" id="A0A6P8I2L3">
        <property type="interactions" value="1927"/>
    </dbReference>
    <dbReference type="GeneID" id="116295471"/>
    <dbReference type="KEGG" id="aten:116295471"/>
    <dbReference type="InParanoid" id="A0A6P8I2L3"/>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13188">
        <property type="entry name" value="FERM_C_PTPN14_PTPN21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000014">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000149">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000039">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041782">
        <property type="entry name" value="PTPN14/21_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF1">
        <property type="entry name" value="PEZ, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="13">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="608"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="788"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031559142.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="101117" checksum="811581A67382C5A5" modified="2020-12-02" version="1">MPFGLLCASGSKNDDSRTWQAHVELLDNSLLDLDLTKDTTGAGCLEIIGQKLGLSEVGYFGLQYFTKKGSEWWLELDKPVIKQLQRHAKDYTNCTLEFQVHFFVANIYCLQEEITRYLYYLQLKSNVLEGRLACTEEAAIVLASYIAQAELGDCTEIQNVNQLMEYELLPRNLVPNKSKVELYQQIFDTYKSYSGLSRSEAEIEFVTLTQQLEGYGDEYYPAKDNKGTLILIGATFLGIIIRHPHGLPPVCFKWPDIVHISYSKRYFCVETTKTLDTIQFGMEDSSTAKYVWKMFVGHHRFRRLNVTRTPREFEKSRPPKKMIVDRKMTLNTLRSKENMAVSTVTLLETSPENSESIDNNDCIDGGAYTPESGIINPLFEDNEADDDEDAIVNGDEDFASNFNIEPVVMRNNSKTNNKRPASSLLPEIKPKHSESPNHILDRPKSVDLTATDINQRPIQGHSEGFVQKNTGSSLGIGSSLSVDSGHPPTLNSSEFFNYGQSLDSLVETEDSGDMMMERTPDFTERSASSNGHLETQEQIKPVRPTSLNLEEVGGIWSNFNTKRTSGYCTSTDSDFSEDNWQQEDEVDEQLSRNEQLKELKKNLAEGQVFTEFQKIGRRSENLSVSTGSLLTNETKNRYNDILPYEETRVHLNPRNNVFNNDYINANHIKMKIGRTLYKYIASQGPMDKTVNDFWQMVWEQNVRLVVMATEEKVTSGSNCMRYWPEEVGRQETYGHCQIVTEHIQDASPYKIRLMKLRHVPSKQERTLYHLQFTDWPDHKIPDDPTNFLEFLDQMESLRHLTNSSLPHGEEKPPVVVHCTAGVGRTGVIILTDLMIACIQNNQRINIHRTLVQLRRQRMQLVANFGQYSFVYTTVIHYLKNSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2R6</accession>
    <name>A0A6P8I2R6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116295501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559192.1">
        <property type="nucleotide sequence ID" value="XM_031703332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2R6"/>
    <dbReference type="FunCoup" id="A0A6P8I2R6">
        <property type="interactions" value="2860"/>
    </dbReference>
    <dbReference type="GeneID" id="116295501"/>
    <dbReference type="KEGG" id="aten:116295501"/>
    <dbReference type="InParanoid" id="A0A6P8I2R6"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000001">
        <property type="entry name" value="Autophagy-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031559192.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36564" checksum="10309FEC6EE6E4A7" modified="2020-12-02" version="1">MAMQDVINKVKGTALGVAEYLTPILKESKFKETGVITPEEFVAAGDHIVHHCPTWQWSMGEESRVKPYLPKDKQYIYTRNVPCYKRCKQMEHQEENEAIVEEDEDGGWVDTHHKVDPSGNKIGAGVQEQFSEMKLDSDKASKPVVPVADDDDDEDEDEEAEDMEAFEESGMLENDEATLSIPAAAAAKPEGAVSSAELASGEGILQTRTYDMYITYDKYYQTPRLWLYGYNENRKPLTVEEMYEDMSQDHAKKTVTIEAHPHLPMTMASVHPCRHADVMKKIIQTVADGGGELGVHMYLLIFLKFVQAVIPTIEYDYTRHFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2U7</accession>
    <name>A0A6P8I2U7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116298501</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562859.1">
        <property type="nucleotide sequence ID" value="XM_031706999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2U7"/>
    <dbReference type="GeneID" id="116298501"/>
    <dbReference type="KEGG" id="aten:116298501"/>
    <dbReference type="InParanoid" id="A0A6P8I2U7"/>
    <dbReference type="OrthoDB" id="5983184at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027836307" evidence="2">
        <location>
            <begin position="25"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="3">
        <location>
            <begin position="418"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562859.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57187" checksum="D8F306CA1F1CB103" modified="2020-12-02" version="1">MAMKENTIIYLALLFPSLCNLNTSTDEAIPLITVQKNGDEAHEFILNPDAISMMKQVSSPVKIIAAIGDARVGKSTALNFIHYTLSNVSSSASDTKNVEEIFVTGDTMNPVTHGVWIAKPNGMNDVILLDVAGVDPGLMLFMKESPSNHTLEFLYKIVRLSEEAFGTKKSEYFPRLTAVLRGALKPPQGYENIDQYITDALITAKWKDESDDQRDAIRTRFPKDHITVFNIPYDASTPKYLKTPKQFLGSEYLESIENLTQHLFELPEKKSLGGAVLDGPALAELAKNLVKDMNDKTRWNDLNPSFYSLFEENLCRKSYEKYIEPLLRLRKAEDMETQKDEKLMLFKENCKLPKCIIQAEIDIDKAITLQKERERQQNDFVTNLKIVVLIAAAVAMVAVVAPVVVVPLLNHFLSRFLSDAQLKENITVLYNSEYETIGLRGVEWVWNKEAERLGLSGKESGVVAQEVELLYPWAVTEGHDGYQQVNYLALRLLIWTKKFQQKAVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I444</accession>
    <name>A0A6P8I444_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Osteoclast-stimulating factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116295876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559692.1">
        <property type="nucleotide sequence ID" value="XM_031703832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I444"/>
    <dbReference type="FunCoup" id="A0A6P8I444">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="GeneID" id="116295876"/>
    <dbReference type="KEGG" id="aten:116295876"/>
    <dbReference type="InParanoid" id="A0A6P8I444"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="SH3 Domains"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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            <begin position="144"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00040640"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS50002"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559692.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23117" checksum="4FFE4EEC9D6CF67C" modified="2020-12-02" version="1">MSSAAPSRPPPPIPRPGQVQVVRACYNYTASQPDELSFEEGDILYILDKGDGQWWKAKVGKKTGLIPSNYVEEHTESVENPLHEAAKRGNIGFMQECLQNKVSVNGLDKSGSTPLHWAAQGGHTECAKMLLSQPRVQVNVQNKLGDTPLHSASWKGHADIVELLLEKGAKTDIKNNDKKLPYDLARDADVGKLLRGSAGEAANDYGEDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4F9</accession>
    <name>A0A6P8I4F9_ACTTE</name>
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        <submittedName>
            <fullName evidence="3">Short-chain collagen C4-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="3">Tentacle</tissue>
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        <property type="nucleotide sequence ID" value="XM_031706491.1"/>
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        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
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        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
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    </dbReference>
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        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562351.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26728" checksum="A496CC4EE859BC4A" modified="2020-12-02" version="1">MRKERTNERKQHTREAIGNLLTCTFLGRDGRDGKDESQGPKGPPGLKGETGHQGVRGPPGPKSGGVQYVRWGRTTCPYNATLVYKGRVGGERYSHKGGAAEYVCLPETPKYGRYKDGLQSLVGYMYGAEYEVSFDLFTKSGLYNHEVPCAVCYVQTPSAKLMIPATYECPAGWTREYHGYLMTAYHGHAHSSDFVCIDDDAEGVPGTHADLNGALLYPVEGRCGSLPCQPYVEGRELTCAVCTK</sequence>
</entry>
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    <accession>A0A6P8I4Z7</accession>
    <name>A0A6P8I4Z7_ACTTE</name>
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        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116296017</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="primary">LOC116296017</name>
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    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559840.1">
        <property type="nucleotide sequence ID" value="XM_031703980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4Z7"/>
    <dbReference type="GeneID" id="116296017"/>
    <dbReference type="KEGG" id="aten:116296017"/>
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    <dbReference type="OrthoDB" id="5956599at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559840.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39577" checksum="2ADF546E0B07DB0B" modified="2020-12-02" version="1">MESSSNTSLKLNSSLPSFPLPDEECLDKTFMLCITVFVLITSLAGNSLVIRFVFRNLKQRKSPDKIFLLQISFSNLLACCVSLPLHYFDVVFIGRIPLSLNVANSLCFIKLFLLFFCLQVGHVTLSVLCYDRYEAITKFPQQRLLTYGIAKQASCGIIVCIFVIYFSSMISYVIDFHSGNTICEGLQIRSMGQQGNAAHVSNIALIVVTVILISTANTICFWNLFLVDRKLRHHKDSVRSTLGDQSMVKEVRLVYSAVSFVITYSIVWIPFGVFRSLRNIFPSSTSIRCYYITAFTCSYMVFSLIPLLYIITDKRIQNPISKFSRKNRVAPDENSTRDTKGPKLTDEKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5L5</accession>
    <name>A0A6P8I5L5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein lark-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116299349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563854.1">
        <property type="nucleotide sequence ID" value="XM_031707994.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A6P8I5L5">
        <property type="interactions" value="2782"/>
    </dbReference>
    <dbReference type="GeneID" id="116299349"/>
    <dbReference type="KEGG" id="aten:116299349"/>
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    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF26">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031563854.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27111" checksum="C5B96F2C976954DA" modified="2020-12-02" version="1">MTEPNETVGEVSSEALTQTTGDSASNVENGQNENTTEEVRNDENETKGPTPSAPNELKLYVGNLPDNCVREDLQTLFSKYGDVSQCDRVKNFAFVHMVGEENARKAISALDDSEFMGTHIQVQIAKSKGKPAEDECFQCGKRGHWAKDCSQRRSGPYRRSGGRYDNRSAPYSYGPRRDPYSRGPAPRDYDYYYDRRGPRDYGGAPPYRSRSPAGYDRRSPDYSMGYEGYGPPRSGYGVRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5X3</accession>
    <name>A0A6P8I5X3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transient receptor potential cation channel subfamily A member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116298896</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563338.1">
        <property type="nucleotide sequence ID" value="XM_031707478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298896"/>
    <dbReference type="KEGG" id="aten:116298896"/>
    <dbReference type="InParanoid" id="A0A6P8I5X3"/>
    <dbReference type="OrthoDB" id="1661883at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="784"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563338.1"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126218" checksum="3D74C14A065AD518" modified="2020-12-02" version="1">MNEEDRRARNFFALKEMLDEQRKKRTKTNNQIFYTASMMTSKTAHVKSSSMLRRSISDSVERNVHRAATLHEACREGLYEEVTRLLEDNPLINSLDDRGFAPLHYAARYQRTQIVSLLIDNGADINVGSSYDQRNLTPLHVASRFDALGVVKVLIDNGADMEKQSVFGQHALHYAAQRASVELIELLLDKGKVNPHVTDNENFTALHVAALCGRLDVINVLLLHEADPCKIDCDKCTPIHYAAKEGRADILRVLLKTASMAGKSCHDILNTDCRETNSSLHLAVQYGHVEAAKVCIEYGADPSAPQESLETPLHVACNNDYIDMASLLVFHGAAIEAKDKDGMTPILRASLSGQVEIIDLLLNEGAKLYPAPGSDMPIPLLCAVNRGHHDAVAFLLKRGSPIDLRDTKYRTCLHIAVYSADIKTVQVILQNGGERLLDARDKDDKTPLHYAAARGDIQILNKLLCAGSHVDLRDEDEKIPLHYASENGNLECVQVLLKKMPSSVDCQDSRLSTPLNYAAADANHVVARYLINKGADVDNRDDNHVSSLIQAAKCGCLITARVLLEKGASINAVDKDRNTALTTAASNGNALFVSMVLDRGADXSIVTANGDNCLTAAITAGHKDVCMAIVKHERWEEACQFEDCNGYPAIKSLIEKFPDVAKVVLGKCISSSGHQENDEKMEVTHRFDYLDPEPNRRTISSGKKFFAPKYMVEGVQKDLLFHPLTLELIRYKWKLFGLRFFYAAAILHLIFLITLGHYVSCQRYLFNHRRLNQTRTIEDEKLQHYCTAQSIAGLELGIIAISLFNLCIEGYQMYTERWNYIETSNVVELTTFSCSLIAISLRLNSIEDEFYWSLTVISVLLAYLTMLLQFQTLFQSGIYVTMLFEVLKTVVKVVSLFTIIFIVFAVTFHLLLSRKNNRAFLGLPYENGTDITKDPFGTIQLSIVKVMVMTIGEIEYSSFFIDEPLWMTDTARNVFLLFCIILPIVLMNLMIGLAVGDIDSIQKNAELKRLTIQIDCIYEFEEKLPFWLLKRFHRSKVVLKPNQKPRTVLQKLKGRLNKRLFSTTNKAPETDLSEAWQKMTEELDNKLQINEERMQYLNSELSHQKEILEKILLTMNPADQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I899</accession>
    <name>A0A6P8I899_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase ZK262.3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563491.1">
        <property type="nucleotide sequence ID" value="XM_031707631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I899"/>
    <dbReference type="GeneID" id="116299015"/>
    <dbReference type="KEGG" id="aten:116299015"/>
    <dbReference type="InParanoid" id="A0A6P8I899"/>
    <dbReference type="OrthoDB" id="5960337at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45908">
        <property type="entry name" value="PROTEIN CBG11750-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027775864" evidence="1">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="143"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563491.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50509" checksum="688CA9053C662BF5" modified="2020-12-02" version="1">MFCTAVLYFLILLVLPDAVELVCDGNNCKDCVKSSIKCRWCKRDGECHMPGAIFTNPCKRAENIVEESHCGNTLSRYKPELSMKMLLLSAAAYDPIDPQGCLNNSLSSAMFQLRIVVTRKCDSSGNKCSAYVAVSHSLKAIAVAFRGSLDSDQALEVFFSALTKPKESFLGGEVQSYWKKGFEELWTCLKEEVKALVTVYPSYQVWVTGHSLGGAMASMASAWLAYYHVGSPTNIILYTFGMPRVGNYDYALEHDKLVNNSWRVVNYDDPVPHFPILLSPNVVILNNPYHHGVEAYYEVRAASPYSQHKECHGKPYNEDASCSFTTVPSFLDLETHKVYFSIPVGTFWKTKCLRSRRKKRDTTENSNTTSPNSFQFKDDVCSKYKYTNHTYVQVAKPSRSTANPTYVQVAKPSRKTANPTYVQVVKPSRSTASKLIGTLHFFLLLIHIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I966</accession>
    <name>A0A6P8I966_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein MLP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561195.1">
        <property type="nucleotide sequence ID" value="XM_031705335.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I966">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="GeneID" id="116297164"/>
    <dbReference type="KEGG" id="aten:116297164"/>
    <dbReference type="InParanoid" id="A0A6P8I966"/>
    <dbReference type="OrthoDB" id="10309230at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="944"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2027"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2234"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2424"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561195.1"/>
        </source>
    </evidence>
    <sequence length="2614" mass="300562" checksum="FF07644DA5F9F1C3" modified="2020-12-02" version="1">MASVVHAKKYIKPHAGVITSAVETHCRPTKIPVWTGYTSRSSSEDSDEQTSRIKSSEIRRSLTASRLPVKFDVVPGSKVDVKDMRTSDVVRPRSERQREIKECLSINQARCNEAIEQGLKQVLPGIMKQLLVQGVGKKDESLPKGRKQSKPRNNGSNRKMSALNISVPRKTSTHRKLPGKLRTSDSSISGNSIKTGNHKTDSDGFSNSEPESVPNKVQSESEKLSDEKEKPKNEYVLENFALSEPLVVPQTVQSGVSDRADKAGDSLNEYILKYETDSDWLTDIDLESIIKQVQSEEEDMSDREDSADDSLIKETSLTHNHKTDPDRLTISDVESLPKQAHSEDDDASDRAYRAYEPDSNWLNEFDLDIKDIIKQEQSEDDLDVSDSQKKAVKVEDPFSTECNITYESDSDALSKSELGNLSQQAHSEDQDVPYCREKKGKAFSDGEDSLSSYSNLRYEADSKRFSDCDMEILPKQFDSESEDNPLGDFTHEYNYDADVDGVTDSEPESVPKQVQMESDFTDEEEGTADKPNDSPSHTRLELSFKSESKNLPQQAHKEKEALSDDEAKESSHTLRLQNLESKFEAVLDDLASPSGSDPECNIKNIRSNHRGEFHEEEGWVPSESESSIGSKLRRFSIELETDELFSTDSEKGRVPTEAELKILSEDEDYAIKVTKDTELTLPSNVEKVKDNQSWEERYTPSSGPADSTHDTHTELNREGLVTAANETREKQEGRSCNETSGTDDVNQSSRGGEGSSEGQEGANTRQGSTAGGSGGDDPNDPKKPKPRKGPEDKKDRDEEQERRKAAKRALIDQMMRIASNLLQNKGKQQEVKTPTQILTNINPVAETAALFEEKASQTNEKESVETLQKTIQSKDREIVLLQNLVDCCRKDYEELQESFNGYIDEFTEVDQLRDMISAMYTDNSILRHDNQKLKNQLYHKTEEAARAYDKNKKYKNNISKMEIDLDSLKSENQELSKKLKSYAATPLCDGQKDETDKEQESGLGKTCSLQDVEAMKAEEENQALKRKLEQFEVSLKAQKKGNTELKEKLAQQKLAQKQLESKIQKLAEENQTLSTKCSRFQKDCSEISVEEIVKDLRRLHEEISEARKDLASDNTVDNSNLKGPTLSPLSIELAEADDCSPQHQPDVNPGVELHTLTYSLTALTEELREQIAKSKVRLTRSYSDNNYSELEQRSNEKMRELNEEIAGLHDKLDEDAEKFKHLEGLLTSSYTESDRMNEWIIELQQELSNSKEMLNQTVVENDQKLDELKSAMEMKDQKLEGMMIQHQNLLEANDALRGVIHTLNMNGATSSSKIIELENYLEELESENEKLFKQLCEQKTILHKIQRESEERQVFSSEDVEQLHYALQNKADSLVDILDTVNQMAANHPGYHDHPCISAIENGLQLVYDVIGLLKAVGHAYMPSSESYVREESVREPLQEETREQELEVMVENLQEENKKLQENMQRYLENNEENRTGRPGEINMLFMESITDPLRDEECRLDKMDDEVGGREANLVQKSSSEIIDQLEKQFHDRQDSEIELQQKANTLRLQIEQLKAEKSKDDTKYQALMNSIDAKQNSLEEQRMKEEQLLMEKLSGMEIAISEMQKEKQNAEQKAQDEINLIRQESQEKVTALEKSLKERRDSETMLENKMFSLEARISQLNAEKAEREENIKTMWEALNARKNLEQHLREKQDVEKQLVKKVENLNLKISRVRTAKKSLRRELAKMHLDNHMNSIEIRNQLQKLKKELVECTEREKVLHDRIKKLTEERDKAESMMEAQATLIKESSEEKMEDLEELLRKKSHSEMELQEQKTSLERELKRLEKEKNEHTIMISAILRAVKAKQNLAKAVKDKCKTEKDYKAKLDEIEMVINKLKTEKSKPNCDVGLKEKYKEKYFELRRIVRKLEDDLNSHNKRVEELQTVVLTAVEDEDKLGKARESNLQRSIATLKDTLRDNHACEIKLYKTLQTVNSKILVLENEKAEGEKMMKGLLRCIGGGETSHQSPSASNTDKAFLRLIGEVIEGVHRLRQVKQRVEEDLENFEKMVATARSENEMLQNQSFERISGLELSLKEKYISETELQERLRSMEKKVANLENEKHNADMAIQAMLESLKSKDELEKLLKQKKDIENKLKQEVLGLEQEKKQNDMKVKFLQQQVHDMEECFKEKTTDTSSNLAQHIQMFNTNLSTAKNGSNNYEEEMEKYNKIFKPETSDGASGLHTIKQVTQTFQQQNHLEEELRQVITTLTEQNKELQEEKTAYIEENRNVVKCLNNLNLELETANRERQKLLAEVTELKSDSSFAARNSRKLIEELTRREKELLEKIDEMKASLKIMEERSQEMMELKIKIAELENRNYEHSAKNKKQYHDQMSESRIAKAKIQDLNLHLQQIIQFEEHLKSDIDFLNAKVTEMSVQIRNEKMKNAEIEKLYSMTKNRITELEQRIACKQEQIDNLRKSNEELRGQVVCLHEEKDNLSSALDDNYHLRLEQRDIQIKQLKNKLEEQEEKIRESARRQDDLTQHQTQMFMGTRGCFSGDVNVLRENDDQRNTTKXIMDSLDDTERRIGKLKSSWKYFEEQQKRSLLSTSIDSVNRNTXACNSSYYRPSFGCSTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I984</accession>
    <name>A0A6P8I984_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300383</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565114.1">
        <property type="nucleotide sequence ID" value="XM_031709254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300383"/>
    <dbReference type="KEGG" id="aten:116300383"/>
    <dbReference type="InParanoid" id="A0A6P8I984"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055312">
        <property type="entry name" value="FBL15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34709:SF57">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34709">
        <property type="entry name" value="OS10G0396666 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565114.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="70646" checksum="2BC5127CEF00AD74" modified="2020-12-02" version="1">MIFSYLHPIDDNLLRLASVCRRWRDIIYNTPLLWQTVSTNPFGSKRLSNALFSRQENEQYELEMALKVVKILRRFGQFILRIKTKCIREESLKSASIFSVLGELKYLKAIKIDLPCESEFLSSLSTSSLLEEFSARGVWFRPHERHFTRIPEEIXLKFADHFPNLRKLELCDCYLSFESMVXALVKLKHLTEIKIKFRLEGGYCNPGVDSAFIRTYRRVEAGKFLTSLAKSEFANKVTVINLEDVLLNGKEIKTFMKCFTSLRKFKLETFIEDMFDSTGIDIESSSLQELKLWDVANIRSVNMXLPNLKKLFISDLHLDXLHICVPNLENLLLGPLRSFDEHLDVFSLETGSLSTLEVTDIGQQNSINMDTLVSLLKKNPKLKHLIIEAGFTTNLTLTRELCPSLAVLTITGSVSNIRASGDSLQRLEVSGDCIDLENDARRTVYLSAKECDLVDVCRMPNLGLMYLDCPKLNLVFISDCAYRFTKSSSLTTMILSEGTTVQTLSIDNICSFDIRSMGKNKIGRLKVQNCSLKSFLPIELELRSLEITKCVNLRTLNLTSISLEEIAITGCSSLESVYLNCPALWRLKIDDDCALTKGENFLYMLQEIKSNCPNVEIVHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAV0</accession>
    <name>A0A6P8IAV0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-like protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562382.1">
        <property type="nucleotide sequence ID" value="XM_031706522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAV0"/>
    <dbReference type="GeneID" id="116298144"/>
    <dbReference type="KEGG" id="aten:116298144"/>
    <dbReference type="InParanoid" id="A0A6P8IAV0"/>
    <dbReference type="OrthoDB" id="207081at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562382.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13774" checksum="E95A5B4FBC9F5836" modified="2020-12-02" version="1">PDRSPPIHYAESSMKNGFGLKYIHTFLNFPFLLLQREALLQQLQVNAMDMESTLEELQLYKQTEEQDYYKYIDYLENKQKERENKLKAEAEARAAAENEANGSKENLSSSPTSPPQTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBM7</accession>
    <name>A0A6P8IBM7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large neutral amino acids transporter small subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564741.1">
        <property type="nucleotide sequence ID" value="XM_031708881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBM7"/>
    <dbReference type="GeneID" id="116300108"/>
    <dbReference type="KEGG" id="aten:116300108"/>
    <dbReference type="InParanoid" id="A0A6P8IBM7"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564741.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17846" checksum="97BBB9F3A180B432" modified="2020-12-02" version="1">MFSAAREGHLPSFMAMIHRTQRTPISAMLFRMATNMEVLSLLFISQGVLFPTIFACMLLIPDKSTIQSLISLYSTAVTVVGLLWTRYKRPELPRPFKLPIFIPVLFLLISLYLTISPFIKKPLESFISPFLVLTGIPMYLFFIRFKCTPKVVSAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC81</accession>
    <name>A0A6P8IC81_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA selenocysteine-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116298838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM TRSPAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563267.1">
        <property type="nucleotide sequence ID" value="XM_031707407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC81"/>
    <dbReference type="FunCoup" id="A0A6P8IC81">
        <property type="interactions" value="2144"/>
    </dbReference>
    <dbReference type="GeneID" id="116298838"/>
    <dbReference type="KEGG" id="aten:116298838"/>
    <dbReference type="InParanoid" id="A0A6P8IC81"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12610">
        <property type="entry name" value="RRM1_SECp43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12612">
        <property type="entry name" value="RRM2_SECp43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034510">
        <property type="entry name" value="SECp43_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040434">
        <property type="entry name" value="TSAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041085">
        <property type="entry name" value="TSAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457:SF3">
        <property type="entry name" value="TRNA SELENOCYSTEINE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17654">
        <property type="entry name" value="Trnau1ap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031563267.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34681" checksum="B6F33AE0C62FF40F" modified="2020-12-02" version="1">MATLWMGDLDTYMDEVFVTNAFAAMGESVVSVKMIKNRTTGAPAGYCFVEFSDSASAQRALSKLNGLPVSGTNPVKRYKLNWATYGKELSNLGPEYSIFVGDLTPDVTDSVLQVFFQQRFPSCKAAKVVLDAAGNSRGYGFVRFFDENEHKKAMTEMQGVVGCGGKPLRVSAATPKRPQTTVTTQAYGATATATQYNAQYAQQYQQQYQQYMQAWQGYQYQQPNYYQQYPQYGTNMYGQDYLHQTTQSYEQDQSAMMAVDTSVEDPNEPIDVAAENKLMAETEAELFYELEGSRWQPVESLSPSPKMLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID52</accession>
    <name>A0A6P8ID52_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer dense fiber protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563937.1">
        <property type="nucleotide sequence ID" value="XM_031708077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID52"/>
    <dbReference type="GeneID" id="116299420"/>
    <dbReference type="KEGG" id="aten:116299420"/>
    <dbReference type="InParanoid" id="A0A6P8ID52"/>
    <dbReference type="OrthoDB" id="429991at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF57">
        <property type="entry name" value="OUTER DENSE FIBER OF SPERM TAILS 3-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563937.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27460" checksum="CF7F870AA67A6FC8" modified="2020-12-02" version="1">MAEVAEDTKAPLIAARERGPGPGRYGLPSTCGFTSHDFTKWKAPAYSFGARLENSMFKKDCSPGPGYFIQPTITKVGKDGTPVYSILGRQKDPNTFKTPAPGTYSPEKVHPQGERHAPAYSMAARTRYRKRDATPSPNSYSLPSLIGPKVPNKYSSSSYSMTARAKTGGFSEDLAKTPGPGRYNTTRPDTYKLKAPGYSMLSRSYMPGDSTKKPGPGAHSPEKVYVNKQKAPACSLGIRHSEFITPLIIDVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDZ6</accession>
    <name>A0A6P8IDZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aprataxin and PNK-like factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563880.1">
        <property type="nucleotide sequence ID" value="XM_031708020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDZ6"/>
    <dbReference type="GeneID" id="116299363"/>
    <dbReference type="KEGG" id="aten:116299363"/>
    <dbReference type="InParanoid" id="A0A6P8IDZ6"/>
    <dbReference type="OrthoDB" id="10256774at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000061">
        <property type="entry name" value="Zgc:165656 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039253">
        <property type="entry name" value="APLF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315:SF2">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PBZ-type" evidence="2">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563880.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59672" checksum="E8C8B5E80AC240DF" modified="2020-12-02" version="1">MSNSQFALRPIDGGKSTVLPLGTTSIGRGPLLSVVDKRVSRSHAILEAQNDKLLVTATHANPTFYKVADKDSFSALKKDESRELLIGDQISLLPNQHVFQVVKESSIDQTNIDVKTAEQSNSEKEANGNGLMQDKDAIESTSSKDEEEENVESAEIQSDPVSQAGMAPKTDVEMLQKNRTLPAWMVPKEEENKATVSTPPKPRGRGRPRKIKEPENTEPSEQRNGNESQSGTIDEGILNPGQNVLPVMRPTVEDRTMEDFDYADDIDDDDEEDREDDDEDEWSPVAKVSSRGRGRGRGRGRGRGRGGGRGRGRGRGRGRPRTKRRSKQYSDDDSEDELSEDDYDVLPKPPKLRKKSRDISDSEEDDPVKGEDEDDKEASSKVTKKDLPACPYGKLCYRKNPGHFDEYSHYFAENEDDDSKPECPYGANCYRKNRQHLEDYRHSQSSEARPKRKASTTGKQSDDSDKGDDEDDGEPNTYDEDVIDKNESSSSESYNQPSADDSDWNPGDDSDEDVKELLSEARGFLRSKKMAKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE99</accession>
    <name>A0A6P8IE99_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent RNA helicase TDRD9</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Tudor domain-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116299587</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031564120.1">
        <property type="nucleotide sequence ID" value="XM_031708260.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IE99">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="GeneID" id="116299587"/>
    <dbReference type="KEGG" id="aten:116299587"/>
    <dbReference type="InParanoid" id="A0A6P8IE99"/>
    <dbReference type="OrthoDB" id="66977at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001113">
        <property type="entry name" value="ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000946">
        <property type="entry name" value="putative ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000081">
        <property type="entry name" value="Tudor domain containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF113">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="12" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="132"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="355"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="20">
        <location>
            <begin position="933"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031564120.1"/>
        </source>
    </evidence>
    <sequence length="1434" mass="161922" checksum="AE2791861F7106DD" modified="2020-12-02" version="1">MADITSDMVNSFFNLSKPIAKQPKVVVNVRGPPPSPDDSYKPEFKLQKKTRPKSPNSEARWNSIAEEDGFLNGDSLSALDLTPPEELAPTDPDAPVPAAFKGEDEAHIFENYSFDHEYSPDLPITQYHQDIIDTVESNSVCVIHGPTGSGKTTQVPQYLLDNYAKDRRYCNILVTQPRRIAATSIAKRVCQERKCTLGSLVGYQVARDKCVSEDTRIVYVTTGVLLQKLIATKNMNQYTHIVIDEVHERDQDTDFCLLVVRKLLRSNSRHVKIILMSATLQSNLFSWYFSMPVRGKMEGAPVIGVEGKIFPIQELYLDDMTSIGQLPNVSLEDPGISDEAYELAARLITSLDFEEKKRLGVDGDEQSCADRGTVLIFLPGILEIKRMDQTLEDLCVNSNLLCLPLHSQITIEEQSRVFIKPDRGVRKIILSTNIAESSITVPDIKYVIDFCLVKCLICDPETNFQSLRTQWAAKSSCIQRKGRAGRVSAGTCYRMVSNEFYETCLTEFGIPEMQRCPLEQIVLQVKLLDLGEPRAILRLALQPPDLDDIERTVLLLKQVGALTTKMRNGYINPHDGDLTFIGRVLGTLPVDVRIGKLMVLGYVFGCLEECIVIGASLSLKSFFSRQFKEELKTYRNKMNWDNSTFSDCLCSLSAYTEWSKLKESRSFGGNRETRWCRENGIQVGRIREVHELVNELTERLKHLNVRSERSVHKKRNKTPEDILILKLVIAGAFYPNYFLSGDIDEAEATKLMSGHDSFTTVMVRGMPQYGAQYKAAIARMFRDCGKGKALYFEETRAYIEFDKSSTAHSARGSTILPAVYLAVKMRGLRIPLNLYIAEGNNRRIERELSNSREEGNRLRTNRMAASLSPGCQRVSFDTTNQPRQVEIPCKGYMEVVVTSPIDVGHFWVVNAEQSSSQAFAALEYRIQTFNYHEPVDHRSCQVESFVLAPFEGTLYRAKVLSIFDDSSRPRKSFVRVFFLDYGNVEEVEFNEVRKIHPEFLKLPFQAIECELCEVQPSYSSNCPSGMWSKQAYARFMQLTNGKMLVAKIYSLVHGILRADLYDTMTEEDIHINQVLISEGHAQFMEEPYSSKMAHQQAETLRGDVRALNDNMDWLNENSPAFNDTSGQYLTKVSLRGPYSPLEMTFFSITSIGRLRTANIDIASVNSVALNDQPQDNHQRLLVAANIGINASGNSVIARDTTLMPNIHGLLPIVALTFAPVAEMRTDPQKHQYTGALVGLGYDAQTNEPLLPDHDIELTFDVEINQEDLIMINSLRTGINLAFSNEGVAAEWGSGAIGRIQQACRKNIISLVLKKREDRKPLSFKRQLRWNQIDPKDILVPSTDDKDDTPDLYQLHNGIAITGQFLDSDTPAKVLERRKMNQKLHELAGRSSEPFTDDVVCELCQVRCRHPRGVSLHLSSRCHKEEESILYENYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEZ4</accession>
    <name>A0A6P8IEZ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activating signal cointegrator 1 complex subunit 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565010.1">
        <property type="nucleotide sequence ID" value="XM_031709150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEZ4"/>
    <dbReference type="FunCoup" id="A0A6P8IEZ4">
        <property type="interactions" value="879"/>
    </dbReference>
    <dbReference type="GeneID" id="116300311"/>
    <dbReference type="KEGG" id="aten:116300311"/>
    <dbReference type="InParanoid" id="A0A6P8IEZ4"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd22419">
        <property type="entry name" value="KH-I_ASCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
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    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047538">
        <property type="entry name" value="KH-I_ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027019">
        <property type="entry name" value="Euk_LigT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565010.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41563" checksum="A95A22627C131F50" modified="2020-12-02" version="1">MDVLRPPVVWIKGRCYRKLPFEQNSSETNENSTPYYEQDEMNYEDETCDASDVVEETKSGFRTVMDTPSALFKFVIGRKAETKKKIEMETDTRLFIPSQGQAGDIVITGPSRSGVLSARRQVEVIAESSRQKCSFTHFLSFPLYFDELATKAEEFKESVLQKFSQTQGIHPSIFQKPCKLHLTIGMLVLLNQEEVDNAAQFLSSCYKDLIRECLHDKPISIKLEGLEIMNDDPSSVSVLYARVNELDGKQRLQHLADSIVQRFVDHGIMQHEYDKVKLHATVMNSSMHSDLEEIARRNNGRKNYEFNKMRRKYAFDAREILQVFEDINFGQYHLKEIHISERGKYDEHGRYYCAASVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGR3</accession>
    <name>A0A6P8IGR3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein LOC116301060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116301060</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565921.1">
        <property type="nucleotide sequence ID" value="XM_031710061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301060"/>
    <dbReference type="KEGG" id="aten:116301060"/>
    <dbReference type="InParanoid" id="A0A6P8IGR3"/>
    <dbReference type="OrthoDB" id="5963019at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15137">
        <property type="entry name" value="7tmA_Relaxin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000393">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1422"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1454"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1538"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1596"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1642"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1676"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="192"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="16">
        <location>
            <begin position="349"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="16">
        <location>
            <begin position="513"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="19">
        <location>
            <begin position="820"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="981"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="1432"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1747"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031565921.1"/>
        </source>
    </evidence>
    <sequence length="2031" mass="229940" checksum="7140ED2A5D5EFA1E" modified="2020-12-02" version="1">SCPLDKLNCEEKISKAEKKCKYSFRGLCTFDNGFCGLKHDNATDLRWTIGTSSTPSDHTGPMFDHSTWDQQGSYIFIEASQRRVGDKARLSSDWMSPGSSVCLQFWYHMYGIHIGALNIITKTSNSKESVIWSRTGNQGERWLFGQVGINITGEFQFIIEGVRGSGSKGDIALDDVTLLEGYCTKVVDPVSPDCAFEEDTCHWHNDGYWLIQNVNDGHIRQNGDRGRYLELKDKTSGQLHSITSADLGNNTWSCLRFWYFIGLGYSANLGVGIVGHGYWSLWSTSKSSDGWTYVQVPLNKVNSSYKVTIQGSSTGPVVAVDDLSLSEVSCHHIPHSTYKSFIPPPVPKCIQSLGMQNFKIPDSKITASSFYRYRTAPRRGRLFLADHYSSTIYTGGWCRGSSSGYQWLMVDLGQDMYVTMVATQGKQELDFWVETYYLRYAKQGGSLQWYYKNGKPHRFNGNSDRHTPVYNHLDPVIVARYIRIYPWAYHGLKCLRVDYFGCPVEEKDNASKCDFSLGIQRGRIPDASLTASSSLDSPHRARLYTVEEGGRLGAWIPEREDNNPWLQIDFGTVVMVTKIATQGRHGNFGENDHFVTSYSVSYSQTGITFDWYRINGNMKVYQGNKDRAAVVYNEINPSLIGRYVRIHPITWHIRPAIRLDMYGCVAVKNDIAKIQNLGCFKDSSPAAIPSLENIDKVLEGNYYERSGAILRCAEAAYKRGFDVFAIQNGKCLSSSTANTSFAKYGKTSACGIDGRGGVLANEVYRIIRNCEKNEELCTWNKFGNQNSNYSLMSRNKPNVTRELKDRIVRINHGDLTPDLTFKETVVHFSNGAQMTSHIMFHSTTSFSLCFWTKCTLPGIVIALEISGKPSILITQEYCKFQIYILGSTATADQCICDDRWHHVCFTWKSQGGVWEMYLDGRLGSFGRWLSGLKTLPALDKMIVSYHISYSNASYKQLQLTEVNVWTETSSPQEILRMSYGCGGNGLHGDVISWKKLQTTMTGNYYLSRNSSCFFEKEGIILDSSQSTKIVSPWIDRSDQEYGKCMRFRYLIHGQGSSVQIFQSVFGDEMAKKTVWTDRNSTKAVWYYGQISIAAVSKTQITVQAQFTENASDFAAIGGVYFTDGYCKTWPSRADEAQTEDMSCNKNQDVCPTSCQCFQSSGNTKRLVVQGDSLLTVPRNIPKQSAVIFFQQNKIYQLKKDDFSSFPSLEYVDISNNVLLRVEDKTFNNLPKIQDIKMSTNFISSLSSNIFNALTSLRVLDLSENIIGTIESDTFSTLLNLTVLSLRSNHIERLHPDIFKNNTNLQYLYLQDNRIEALPDGIFSNLKNLKVLYLNDNKIKKISFGTLQGLVSLQTLFLQNNKFSFVNPETFEQLRNLNILKLDHFTLCCYAVKAIPGVDCDSPVDEFSSCDDLMKNKGLQICVWVLGMFAFLGNIGVIIWRVLFREENKVHSYLLTNLAISDFLMGVYLLIIAIKDAQWQGEYFKKDYEWRNGILCQLTGALSMLSSEVSVLMLTLITADRFVSIVFAMRFGKLSYKKAIVMCLIIWSFGLLISLLPLFGMTYFYDTKRDMGFYGRSSVCLPLQLSSSRPAGWEYSVSFFIALNFISFMFIFVAYILMFWTVKKASNAARSTNAKKEAAMARKLLFIVLTDFCCWMPVILIGIFSLTGDFHDPQGLAYVWIAVFVLPVNSSINPILYTFSNANVKKKLIDYGKTMSTASYANHSMVILSTVRDNHNHQQDRSSSNKVHLLEKRIQAAQRPKVHSILNKKIEPLVKKRKIKLVEVCDIFTSIKPKGKVYVTCWNETSQSMGLLKIFAPGKHNEWMKEINVLNRINIGRDHDNLMNYRWHSKVDSLEIDSNNVSIPGMSLSQNCRVICFDFAAASSKSLGRFLGETGFNANIESLFILSLDVLKAVEYLHQNEVCHGDINSHNIVIGKFRRIPPIKALVGGFDKASIVKSGTKADEAYKLDIVQVGTLMKQMLDSCGYTEDFQQISVVIDMCFQESFIWKRRAKEIRTRLEQIWITSNEWDSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGV2</accession>
    <name>A0A6P8IGV2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allatostatin-A receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566057.1">
        <property type="nucleotide sequence ID" value="XM_031710197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGV2"/>
    <dbReference type="FunCoup" id="A0A6P8IGV2">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="GeneID" id="116301176"/>
    <dbReference type="KEGG" id="aten:116301176"/>
    <dbReference type="InParanoid" id="A0A6P8IGV2"/>
    <dbReference type="OrthoDB" id="5966012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566057.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33318" checksum="9993A08FF1546C7C" modified="2020-12-02" version="1">MMPSTQEAIFAVLFSAVLVFNIAGNSLVIYIIRNEPGMKTPTNYLLLNLAVADLLFGVFLAPDYILLPFFRHFLPDGVLGEWLRKLLLASNIAWLACRASTFTMICLTVERYFAVCRPHTFRQRFSPKIVKVLVVVSWIYALLIASPLFVYTKLSSREYLFCLFDITALYSMFLWFEITCSLALMIFFPVKIYVSLWCKQTVEPTGEREIFERKKKKKVTLCVLAVVVTFVVCWIPATASYIISNTRIEAFEIATTLVASFNAALDPYLFSFQSSRFKVLVKKVLCCRKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIS4</accession>
    <name>A0A6P8IIS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 58-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566707.1">
        <property type="nucleotide sequence ID" value="XM_031710847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIS4"/>
    <dbReference type="GeneID" id="116301737"/>
    <dbReference type="KEGG" id="aten:116301737"/>
    <dbReference type="InParanoid" id="A0A6P8IIS4"/>
    <dbReference type="OrthoDB" id="1053178at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566707.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40887" checksum="95081410CCA0243C" modified="2020-12-02" version="1">MDEEDVGATSSEIEPFELNLSHRFLEELPEEGFLLNNLNPLKITCLSLLGNQISVLPDSISLFKNLVELDVSSNGLVAISPRISELKNLSNIVAKNNNIEELPKDFGLLCRLENLNLSGNKFHSFVPQIFELANLRALYLGGNMINRIPPQIQSLKKLEILYLGGNRLKGIPAEMGYLQKLRALNLCNNMIESLPFTLKWLSSLHSLSLHNNKLTTLPIQIVRLKNLESLSLRDNPLVVRFVKDMVFDPPSLLELTARYIKNHNMKYTVNDLPPTLVRYLDSARSCVNPRCKGVYFDSSVRCVKFVDFCGKYRVPLEQFLCSPHENYRWEEYSFSSGSGVSSDEEDELVPRDKMRKVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJI5</accession>
    <name>A0A6P8IJI5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Tyramine/octopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17 18" type="primary">LOC116301882</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566902.1">
        <property type="nucleotide sequence ID" value="XM_031711042.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566903.1">
        <property type="nucleotide sequence ID" value="XM_031711043.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566904.1">
        <property type="nucleotide sequence ID" value="XM_031711044.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566905.1">
        <property type="nucleotide sequence ID" value="XM_031711045.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566906.1">
        <property type="nucleotide sequence ID" value="XM_031711046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJI5"/>
    <dbReference type="GeneID" id="116301882"/>
    <dbReference type="KEGG" id="aten:116301882"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000523">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
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        <location>
            <begin position="31"/>
            <end position="55"/>
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            <end position="255"/>
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            <begin position="47"/>
            <end position="287"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="RefSeq" id="XP_031566903.1"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031566906.1"/>
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    </evidence>
    <sequence length="374" mass="42516" checksum="332152E7CBC0D858" modified="2020-12-02" version="1">MNSSLGKTVMSNKSQNSSIDLSYQANLTTTLVSSTFLILIMIMALVGNLFVLYAFKIFHKLRTVTNFFIVSLAIADILVALMSMPVWATYLIKGPSAIKYLWLQQFWSFMDILCGGASIIHLCFISLERCICISTPFKHQVIVTTGKVQISIACIWMFSCSVASLKIILWEYPPPIYELTVTISCFVIPLIIMTICYVKIFQNARHQIKKMIFTVEGKPKRFLLSRELKAAKTVGVVIGAFVICWCPFFVLNLVYGLCKSCRPLPNESILVGKWMHYVNSVLNPIIYTCMNKDFRSAFKKLFLYICACVMGKEYHDLLTEQRSFYSERASFRNHSCRSGASVAKMDDHNSSQRSAAESYVLHSNYSTIDRQSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJW9</accession>
    <name>A0A6P8IJW9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radial spoke head 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567211.1">
        <property type="nucleotide sequence ID" value="XM_031711351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302130"/>
    <dbReference type="KEGG" id="aten:116302130"/>
    <dbReference type="InParanoid" id="A0A6P8IJW9"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="MORN"/>
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        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567211.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26984" checksum="8BC8080C1089E1C4" modified="2020-12-02" version="1">MGSHYAQGNWLETDSAEDEQDLGRYDGDRNENDERHGVGRAILPGGDVYEGEYKDGKRHGKGKYKFINGASYIGDYFEGKRQGNGTFLYPDGSVYQGEWKDGARSGKGRYVYPNGDVYHGMWKDDKRNGKGEYIYKGKQIKYNGNWVNGGFGGKGKITTTQYEFEGNYEDQEPIGVGRYDFNVGCTQIGEYSFKRIVVKKNDTREVYHIPKWRCCRLCYAEKKDEPNNTDEXPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKU2</accession>
    <name>A0A6P8IKU2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19 20">Acetylcholine receptor subunit alpha-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19 20" type="primary">LOC116302016</name>
    </gene>
    <organism evidence="17 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="18 19 20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
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        <property type="nucleotide sequence ID" value="XM_031711196.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="aten:116302016"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519128" evidence="14">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="54"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="270"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031567056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031567058.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="56226" checksum="D64C0CFA84A71789" modified="2020-12-02" version="1">MASTAKCMALAFLWLCLYVSAINSTNLTDGIAFPTDEVKVYDLENSQQDDDELKLVKDLFLSGYNKNVRPVEDKNLPVEVKFGIAYTQIVDLIEKDQVLESNIWVRMKWQNHLLKWNYSEYGGIKAINITPLLMWLPDIVLHNNAEENLPSGTLDQFKTKVQLNYKGECTWYAPTILRSGCNIDITYFPFDDQLCELKFGSWTFNGLQVNIVQMTDEADLNFYMKSSEFQLISAKAKRNVVRYSCCPEPYPDVTFYLHLRRKPGFFLYNIIIPCLVITSLAVLTFLLPPEIGERVTLVIESFLALSFVILMVSSSVPVTSDNTPLIMKFLLISMCQIGCALIANCISLNLYKKEEMPQWVRVVFLHYLARCLCISTGHPKGGVSPKKSKDEDTQDKKVLASMIHKNSYNSIDGPVSPLLPRKTSANSDHQMSKAADGIAAVAETVLKEEDFEKDRDFWIFTSIVVDRLLLIIFTLTFITSSSFIFSMVPDHYGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILS0</accession>
    <name>A0A6P8ILS0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116302259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567353.1">
        <property type="nucleotide sequence ID" value="XM_031711493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILS0"/>
    <dbReference type="GeneID" id="116302259"/>
    <dbReference type="KEGG" id="aten:116302259"/>
    <dbReference type="InParanoid" id="A0A6P8ILS0"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567353.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31827" checksum="BD443127050A3395" modified="2020-12-02" version="1">MLGDARPSTEDDSDNFVTSVYLIMKSYILQKSEKSLLYSMESILIVLVSALLFRNSDAGSFTWLQWDNTVNVVEGDTAKLNWSVRISAGKTWVAVNITRNIRDTTGPGDVDMIRRKPSGVEILLPERGADMDLDVQANLNVLNITFSLRNISRKTDEMYYRITVFDDDRDSSLRYTKLNVNVPSSCDIHPNTTTVNETDKVLFNVTTTGNPPVYEYIWTHPNGSRLTANSRLTFTASRQDTGTYKISVYNGVGNRSVCSSNVTVQCELMHLLSMVVRLYHLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMW7</accession>
    <name>A0A6P8IMW7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoenolpyruvate carboxykinase (GTP)</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116303070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031568381.1">
        <property type="nucleotide sequence ID" value="XM_031712521.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IMW7">
        <property type="interactions" value="1129"/>
    </dbReference>
    <dbReference type="GeneID" id="116303070"/>
    <dbReference type="KEGG" id="aten:116303070"/>
    <dbReference type="InParanoid" id="A0A6P8IMW7"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="12">
        <location>
            <begin position="50"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="11">
        <location>
            <begin position="283"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568381.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="72284" checksum="BF3FD0C71DEDCC87" modified="2020-12-02" version="1">MSLVXLITRLPRSSSSRSLPIRYRLILRTMSSLPPFEKGDLNSLSSKVQEFVSGYAEIFKPQNIHICDGSNEENQELIDKLIKEGACVPLTKHDNCYAVRTDPKDVARVESKTFICTENRYDAVPHVKEGIQGALGRWMSIDDAEKELETRFPGAMVGRTMYVMAYSMGPVGSPVSKIGVQITDSPYVVCCMRIMTRMGAKVMKVLGDGDFVKCVHTVGFPNDGKKQPTVPYWPCDPERTLILHFPKTREIKSFGSGYGGNSLLGKKCFALRIAGNIARDEGWLAEHMMIMGLTNPEGKKKYIAGAFPSACGKTNLAMLTPTIPGWKVECVGDDIAWMWFDEDGQLRAINPESGFFGVAPGTSKKTNPIAMKTFEKDTIFTNVAETSDGDFWWEGLDPPKEGITIKSWLNQENWTPDKGFAAHPNSRFCAPSDHCPIMDKDWENPKGVPISAILFGGRRPVGVPLVYQAFNWQHGVFVASSLSSETTAAAEFKGKNIMRDPFAMRPFFGYNFGKYLEHWLGMQKKSDKLPPIFHVNWFRLDDNGKFLWPGFGENCRVLEWIFKRCDGEDLADVSPIGYIPKKDAINTEGLGKIDMDELLSIPKDYWMDVLKNLRKYWDEQVGEDLPGPVNDEFKALEERLKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INL2</accession>
    <name>A0A6P8INL2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab9 effector protein with kelch motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Rab9 effector required for endosome to trans-Golgi network (TGN) transport.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568412.1">
        <property type="nucleotide sequence ID" value="XM_031712552.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8INL2">
        <property type="interactions" value="1168"/>
    </dbReference>
    <dbReference type="GeneID" id="116303096"/>
    <dbReference type="KEGG" id="aten:116303096"/>
    <dbReference type="InParanoid" id="A0A6P8INL2"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031568412.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39141" checksum="0C8F2BB387506709" modified="2020-12-02" version="1">MEVHPILDDLDNIKPNLWYVLSPSGESPSVRVGHTCTYYFGLKSKDAQSQRPRKGNVLIVGGANPDGPFDEVYILELNTIKWNKTEWKGLFARYEHSAFIPASSPSSVLVFGGACQSQNLNDIQSLNTDNGTWYKLEANGEAPASRTCHSMASIGDSLYVFGGGRTGPDPVQXDSMHVFDAVTTTWNKLETCGDKPSCRHGHVMVAIGTNIYLHGGMAGTSVFDDLYQFNTVTNAWIRLSPTGDVPEARTAHAGTAVDKNLFVFGGMSGIGSALDDFYMLNTVTVKWNKIKIDAIPPNPRLDHAMCTVTFQPMQEEKPEANDAEKDKTHQLVFIFGGMDTRGEILNDCFVFLPGPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQB6</accession>
    <name>A0A6P8IQB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569102.1">
        <property type="nucleotide sequence ID" value="XM_031713242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQB6"/>
    <dbReference type="GeneID" id="116303660"/>
    <dbReference type="KEGG" id="aten:116303660"/>
    <dbReference type="InParanoid" id="A0A6P8IQB6"/>
    <dbReference type="OrthoDB" id="4777606at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042477">
        <property type="entry name" value="HMGXB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584:SF1">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="671"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="671"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569102.1"/>
        </source>
    </evidence>
    <sequence length="826" mass="91000" checksum="B3CC01AF93B3CB70" modified="2020-12-02" version="1">MSHKRPLKRSINTLDDTSCDYSPSLKSSLSKRSRIEEYIEQTKTQDGESSVRRSSRAPKPKVFDDDYTDISVRSPGSEREIPKKKESKSISRNQGERRSIDDVLGIVDDEDSSASTKRRSSRVPKPKLFDEDYVETASFRGIDDKKEKNMSVATEIRVSRDSPKDSTFQKGSAKFKKTGSSSKRGKANATATPGQGKPSIQDNSPLELQSQQAMKGNEGLGAWYSPKVRTSSRTPVPKKTFTLIDESPVSRLGESLFDGGDLYVDVMTQEPHVAKQSKKMSLGHSDSSSASGEIIDIIGTSPVSSKMKWTSKDTGSDGGKNKKSKKSKKALDSPTVLKNIVTADVPKKSETNKKESEMRSETKEKVKKVSSKAAKKTSDSKVDSKKRTAKSKTNDSSEDMVNVVGVQQVAVKKKTKKKKLEFEQSGLSHVSSEGTKSTASLSSSASEHGKKTSKHSKPKHKNEPHSEVKDEDHHIILKVHLPHGEAPHHSHHSHSHKKHKHKHSTSESKSESSSETKIKKQKLSLELEGSTSEDKHKKKLSIKFKGLSSSTPGVEFQGAEKTVEKEVKKNKDADNAIKKKKSKNPLPDKPLIATGSDEKEHVKVVIKKNKKDVKVLTDEDKKTTQKITTMKDVKEKAKEDKAHDKAETPIKTTPKKKAKAGESPKSADKEKRKIVSGYLLFCKKERSRIYEANPGLEFAQISQKVGEAWKSLPESTKQEWKAKADDIKKNYLAVPKDETAKPGPDAVDMAAHLKLLGESLSVIGLSLMAQKETEVHGSLSVLLDSILCAICPLTFLTSHIPGISGISKEKQTQILDDLAYTMPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQH3</accession>
    <name>A0A6P8IQH3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cingulin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569326.1">
        <property type="nucleotide sequence ID" value="XM_031713466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303854"/>
    <dbReference type="KEGG" id="aten:116303854"/>
    <dbReference type="InParanoid" id="A0A6P8IQH3"/>
    <dbReference type="OrthoDB" id="10313976at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569326.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29923" checksum="47E6C145EFA01E9A" modified="2020-12-02" version="1">MVIFNQRKEPTLLNNALSKEITAALGNPNITLLSTLTKKETTRLQEEFLKSVKMPSAKASLEXMNALLNKQREKLQRLETVKGEKSEELKKLPPNSDATGGLVSYLQNARAEREALQKEIQENNITINDLTRQLDEATKEGGGIDSRFEAVQEENQALQGRIEELEDEFIKQGRLTSASHTAEIADFKARLSKLVEEKSRARKQLKIAVNEAAGKDAELQRLGKELMESVDRERKVMADKAVAEERIRQLQQAVEDLEGHPGVLDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUE8</accession>
    <name>A0A6P8IUE8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116305005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570679.1">
        <property type="nucleotide sequence ID" value="XM_031714819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUE8"/>
    <dbReference type="GeneID" id="116305005"/>
    <dbReference type="KEGG" id="aten:116305005"/>
    <dbReference type="InParanoid" id="A0A6P8IUE8"/>
    <dbReference type="OrthoDB" id="5975666at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031570679.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31813" checksum="43E21F4F0A479A80" modified="2020-12-02" version="1">MTLEWGLSDLQKLEINGCAVSNVGGLKSSDHRSKEIKVLDDLVVTNGIVVKGGEEALSKTIAEKDSRVVSLEKLVEQDKNIQEIEMKEFNENHAKNMKKLDEECEREINEADRNFKIKITEIIEKNEGSKQVITTPTKENLNISYCQSYIRQVCLILQANMYHIVLPDQFAEDLPYKVKDIEEDKDFLDEDERQKAWKRWESLKEKLCWDPPLKRTLKMLQKEGNSMNKPEVLTVEEAERVAEELNKQGRLRGRTSYKKVKKIIKMWKISTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUW1</accession>
    <name>A0A6P8IUW1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116304376</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569965.1">
        <property type="nucleotide sequence ID" value="XM_031714105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUW1"/>
    <dbReference type="FunCoup" id="A0A6P8IUW1">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="GeneID" id="116304376"/>
    <dbReference type="KEGG" id="aten:116304376"/>
    <dbReference type="InParanoid" id="A0A6P8IUW1"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19334">
        <property type="entry name" value="Wnt_Wnt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009140">
        <property type="entry name" value="Wnt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF37">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01842">
        <property type="entry name" value="WNT2PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028296510" description="Protein Wnt" evidence="13">
        <location>
            <begin position="23"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031569965.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43228" checksum="403492FC8322ACC9" modified="2020-12-02" version="1">MRRLGFLLTAVIFLSLPHQSCSHWWFMSQVYALGAKVMCNSIAGLVTIQRQICRENPDVMISVGKGAKLGIHECQYQFLYQRWNCSTAERDASLFGKVMRRASKETAFVYSISTAGVVHEVTRSCSLGELKECSCDNRRGRSRKGFEWGGCSDNIMYGLNFAKAFVDSREVERDARALMNLHNNYVGRRAVKTNMLLDCKCHGVSGSCSVRTCWKTLPPFRIVGEYLKHKYMTSQRVTVDQSGKALTRADIIYSRPSRDELVYLEESPDYCDIDAKTGSLGTSGRECNKTSTGTGGCKVLCCGKGFNTIQVEEEYKCSCKFHWCCHVKCQKCRRTVDKHICKGAKDIPANVKKGSSRTNSKKNRRKNKKRKDRRKDSGTPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWB6</accession>
    <name>A0A6P8IWB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginine and glutamate-rich protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571666.1">
        <property type="nucleotide sequence ID" value="XM_031715806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWB6"/>
    <dbReference type="GeneID" id="116305835"/>
    <dbReference type="KEGG" id="aten:116305835"/>
    <dbReference type="InParanoid" id="A0A6P8IWB6"/>
    <dbReference type="OrthoDB" id="10315010at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571666.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="52486" checksum="055E46B0FC8E6FDA" modified="2020-12-02" version="1">MEIITDLNDCAGDELIRKYKESLQSKIVELQNAVDNNDKKVVEITEKYMNEINLRKNAEATAEDTNSKMEELQNALNSFQQRTSALEKEMEAYKLALQERDLQSSNGSLGEEFSVEGDEAQQEQVLQFSQSSLNEEIFEEMVDAEHEEASRQDELREKFIEQMNRAVHEQALELSKCSLSDALLNQLEDPKNIRECEISLSLAVLSEKLTQERQNSFILEDKVAELEKSFHELCELKESIVEEAENHEEWLKAMLTKEREQNEKLSNESDRRIDELQEKLKDALEINSQLMKWKDGVCYSSSFHEETEQRYKEIIAQYEIELEEAKRGLSDIRNELLALRSEQKRRLEEERENEIFTSTPQKHKPPPLGCEVSLNEEIRHEEEEEEEEEEEEEENEIFTSTSQKHKPPPLGCELSLSEEILMKLKYGNQKYRVKLAKLIWNGMENLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWJ4</accession>
    <name>A0A6P8IWJ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Equilibrative nucleotide transporter 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571761.1">
        <property type="nucleotide sequence ID" value="XM_031715901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWJ4"/>
    <dbReference type="GeneID" id="116305902"/>
    <dbReference type="KEGG" id="aten:116305902"/>
    <dbReference type="InParanoid" id="A0A6P8IWJ4"/>
    <dbReference type="OrthoDB" id="10014563at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571761.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48067" checksum="8EC6EFE4AEA84E96" modified="2020-12-02" version="1">MTMADLEAESEQFLNEDGFSSPSVVKDRPLAAMLKKKNVSMYLQFVFFGIGSVLPMFVIFAAVDYFDDIFPKTEPEFALNVIYNPLLFCGSFVNLVWGRGSSFRWRIVCGFGVMALSMLGFIALDRLELCGDPCINPHKFHYWAVLAMAGVLGLADAVCQSTLFGLTSHALPPLYTQGLMFGASLCGFIITLLRIVTKSTTASMHLSTYYYFGATAFFIAVVIILFIRLTKGRAFQRYYSRAAKYSLDTDLKSPFKRFACFSYEAIKVLSYKRVFCYCFLLMLIQLQQFMVLPSVITMANDFLGKGWYPVLLVLVYNIGDMLGRGPMSLYYTYNLGWAWLSTFVRFSLIIGICLSVPPYMLSRRPAWMATFVGLLGLSTGHLNTSLMSHAPLDVPGKAKETVGYLGVLSMTLGMAGGSALSLGLKALIERVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWN5</accession>
    <name>A0A6P8IWN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116305654</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116305654</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571474.1">
        <property type="nucleotide sequence ID" value="XM_031715614.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571482.1">
        <property type="nucleotide sequence ID" value="XM_031715622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWN5"/>
    <dbReference type="GeneID" id="116305654"/>
    <dbReference type="KEGG" id="aten:116305654"/>
    <dbReference type="OrthoDB" id="5966010at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653245" evidence="1">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571482.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32872" checksum="1402D3AC6D8074B9" modified="2020-12-02" version="1">MDLFCFGVLILICLEINHITGQQLDNTKRVWSECSLTCGGGTQFMLKNKTSTRLCNTMSCPGDAGCISTYQSFDHVTGKTIYDESNNGNLATMKGEAKIIDKGKFGKALKLSKNGSVSFDVIHFRNRPSLAITIALWLKLSEIKGAQEIFYTCGDTSRYNIGAYHITVDNGIVKWSRKNKDGDKIFSLAAGKPMKNSTWYHIAGTYRLSTGKARLFINGKISNETKTSKPQSTPKLNDNWKCADMGNPSAKKPVEGILDEFYIFKCELLPEEISELFSKNEFKKFKIPRPNSNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IY67</accession>
    <name>A0A6P8IY67_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Receptor-like protein kinase At5g59670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116306188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572102.1">
        <property type="nucleotide sequence ID" value="XM_031716242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IY67"/>
    <dbReference type="GeneID" id="116306188"/>
    <dbReference type="KEGG" id="aten:116306188"/>
    <dbReference type="InParanoid" id="A0A6P8IY67"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="term" value="F:protein tyrosine kinase activity"/>
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        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
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        <property type="entry name" value="Tyr_kinase_AS"/>
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        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
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        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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        <property type="entry name" value="RAB"/>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="302"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572102.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="61215" checksum="4E798C2F5B778FC5" modified="2020-12-02" version="1">MNMSVRYSKARPKDKIDFKNQIGKGSYGEVWLAEWNGQEVAAKKLHPELLKAEYGQRAIDHYIGEFRKEWEVLRQLKHPNIVKMHTVLFPPNESPVIVMELLHCDLLHYIEKSTSTPKVSPSEGLSIAIGVAEGLQYLHEQSPPVVHRDLATKNILLTVDGQPKIADLGVAKVFAGGGEAQAATAGCGTPAYSAPETYLDTFNYKAKYGVKVDIFSFGVTLLVIVVGHEPVVFPKKIKIDGSRFSEIERRETHLEQIKDHRLERVILDCLHDNSSMRPHAHEIVKKLKQIKRNTTGETKPFFGQLARCNPNIEFMEVSSQSRYDHDWKVIFLGSSGVGKSCLVNLLKDPQYDIKLQESSIGLDFKGFSYKYNSQYLKITITDTAGQERFHSLPPNYIRNSDGVLLVYDVSNKTTFDMLPYWLEMIEWHAYENRKILLVGNKVDLREPTSDKPTNSSDEPLVVQEHALTLASDLGIPYMETSAKDIESICNMLQYMVEMLMTPDSACVEDVHVEDGERPPSSCSSFPPEQERKKLCPRCRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYQ1</accession>
    <name>A0A6P8IYQ1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031571073.1">
        <property type="nucleotide sequence ID" value="XM_031715213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYQ1"/>
    <dbReference type="FunCoup" id="A0A6P8IYQ1">
        <property type="interactions" value="1272"/>
    </dbReference>
    <dbReference type="GeneID" id="116305326"/>
    <dbReference type="KEGG" id="aten:116305326"/>
    <dbReference type="InParanoid" id="A0A6P8IYQ1"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571073.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="15802" checksum="572359742E48D5AB" modified="2020-12-02" version="1">MVVKAVCCLIGEVKGTIHFTQEGDGKPCHVSGEVTGLTEGKHGFHIHQYGDNTNGCTSAGSHFNPFNKNHGGPEDAERHVGDLGNIVAGKDGVAKVDMMDKQVTLLGEHSVVGRSVVVHVGEDDLGKGGHDDSLTTGHAGGRLACGVIGICPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1U7</accession>
    <name>A0A6P8J1U7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptide Y receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116306164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572073.1">
        <property type="nucleotide sequence ID" value="XM_031716213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1U7"/>
    <dbReference type="GeneID" id="116306164"/>
    <dbReference type="KEGG" id="aten:116306164"/>
    <dbReference type="InParanoid" id="A0A6P8J1U7"/>
    <dbReference type="OrthoDB" id="9835116at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031572073.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="37491" checksum="4EF103B603C4A409" modified="2020-12-02" version="1">MNGSDNLTQSSLSCFSVPDSHLVLTVKIMAILLVGGFAVFGNILIIFLAARFTVKRNIHHLIINMAVSDILVAIMYSYHNIRSLLRLPYFWELWDNDVFGNILCKAYYFFYSASKYVTLTSLLIISVERFRSTKVTVRRVRPYTLKKRLALVSCSWLLPMGLKAYVPWYFKIHQDSNTRGCYPNFLRAFFVLFSFDQLFVLLTMCLVVIFNIMTSFRLCKSRRTFPQGNFTEEQNRTREKRTAKAVKMVLCSLLLYTCCYLPGFVYYFLFAFDLTTEFPSYSFETLNFMLSFLLLVNSCFSPCIYIVFLIEFRQAAKRLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2I4</accession>
    <name>A0A6P8J2I4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATM interactor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573774.1">
        <property type="nucleotide sequence ID" value="XM_031717914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2I4"/>
    <dbReference type="FunCoup" id="A0A6P8J2I4">
        <property type="interactions" value="1712"/>
    </dbReference>
    <dbReference type="GeneID" id="116307641"/>
    <dbReference type="KEGG" id="aten:116307641"/>
    <dbReference type="InParanoid" id="A0A6P8J2I4"/>
    <dbReference type="OrthoDB" id="6354171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055303">
        <property type="entry name" value="ATMIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056380">
        <property type="entry name" value="Znf_C2H2_ASCIZ_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46664:SF1">
        <property type="entry name" value="ATM INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24761">
        <property type="entry name" value="C2H2_ASCIZ_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573774.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61039" checksum="8C85F083D7A1A41E" modified="2020-12-02" version="1">MADDVEEICPAVEILTSIETAVPCPVKGCSKILCNKASLRMHVVKTHNITESEEEKALFTRNSEKRKCTKKHFYCPVLDCSRGKSSKKPFPRLGQVKQHYMTVHAEKQYTCDKCSRGFGLLAACKRHESKCGQVFHCGCGCPFTTREALLMHVRRKQHSLPPKKQVPETTAVFDNMQTTRTTIPVQVVKPATMLTATTVKQGQEKIPIVSQRYCKILPKPVNLPNQISTSPFTGNCVASVTTRDAETQTLKRKCFRNISTQTMLDISTCVDSEMISDTGTRLSNASVGTQANKHLLNAVSMIDFSSQVMVPDMDGNSISQSSSIGIQHDHLFMPHHSSLGIQEDPTCFSLSSQTLLTGSNLQITDPRFQSTSETQTQDLSQVALEDNASQTSISIFGFDPSISMDCATQTQAQKIFDELWNQSDVELTESQTQTWLSSLMPTESEITNQNHLLIHRTTLDDLVNIRTQTSSMTNTMTFEAGLTNTETQTIPEAFATNSWPFEPIDRQTQMTQTATQDVIYNQLMDTHTQTFLDDIDNVSVFSSVQTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2Q0</accession>
    <name>A0A6P8J2Q0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116308052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex. The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Directly interacts with CD2BP2. Interacts with HNRPF, HNRPH2, NEDD9 and PQBP1. Interacts with ERBB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574266.1">
        <property type="nucleotide sequence ID" value="XM_031718406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2Q0"/>
    <dbReference type="FunCoup" id="A0A6P8J2Q0">
        <property type="interactions" value="2285"/>
    </dbReference>
    <dbReference type="GeneID" id="116308052"/>
    <dbReference type="KEGG" id="aten:116308052"/>
    <dbReference type="InParanoid" id="A0A6P8J2Q0"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574266.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16715" checksum="ADE2DC61E7F1145E" modified="2020-12-02" version="1">MSYLLSHLENGWQVDQAILSEEDRVVIIRFGHDWDPACMKMDEVLYSVADRVKNFAAIYLVDISKVPDFNKMYELYDPCTIMFFYRNKHIMIDLGTGNNNKINWPLDDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2Q9</accession>
    <name>A0A6P8J2Q9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 64-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571940.1">
        <property type="nucleotide sequence ID" value="XM_031716080.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J2Q9">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="GeneID" id="116306050"/>
    <dbReference type="KEGG" id="aten:116306050"/>
    <dbReference type="InParanoid" id="A0A6P8J2Q9"/>
    <dbReference type="OrthoDB" id="5980302at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF2">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="512"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="935"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571940.1"/>
        </source>
    </evidence>
    <sequence length="1152" mass="130435" checksum="C54B33C60DD3E850" modified="2020-12-02" version="1">MLQRQNSSRPYTSGSFRTKLQLFDEFIKEFTFVDEELNPEERRQILQDRLTNGYEPFCEAIRNLFGNDVTTQDLKALFRKIALNPDAKVDWSELFGIGGATDEVPDLLLNEDTSSVITTSKRRTVGEAGGDKKRRDVVQCIEHVPKYNFYVTASQKGIICQWSNKFRLQACTDINESSWVTGCGFLPSLRRIAVTSERAVALWDYRAKRKQSTIYQIKPIENSPQCMTYIPWKTNSMNEDTLLFGDDQGYVNMLTISSKDLHMKNSNTKADSVVVNIEPSKLSSEIKRRKFHDDWVLKIKYFPQLEMFGSCSPSSTCSFVLGNLDRVLNNGPVRELAVPKGVNCFDYCMRANVIITAGADKIIRIWHPLIFTRPTGKLLGHLFTIVEVCVNEKDQQLISLSTARVFRVWDIQTLTCLQVFTDNEVRPGEKRISSMLFDAKNDRLITGCSVIDTWPLTRAIQDSLQVPHTHDRPLSQLLYNPHMSQVISVCTEGIMKVWEMETGQAIYQXPDAHGPSNEITAMNIDNTGYRLVTGAYDGSIKAWDFGSGQLYKSFPDEPSKHQENTITGLVYHTIGDRRCLFVSSWGKGIRILEDCYDLPMFSELRILSDSFTPPNSIAVPEGPTPFISRAPLPGIGQEPNSLKQMNLQRSCEVTCLEDCSGSLLMAGTSDGAIIMWNLETEKVISRFVLPATSGSPHSGGAKRQRREDQSLVHACRFLVHKVRRPIIYGEKTFRLHTVEEESESELETEKSTSHMEETEEKTPEKSGSISEVQDDGDVEMKEDERDKVDIKSDGGQNYGDNDDDDDNRKDDGDDEKHDDDEAKDDNETDSPYLRISDPAVLSCHHDGYLRFWNLEGRMLNEIRAVTRRQASAVTCVTTDVDCNYVISGDAKGYVTVWEVGSFLLDPPKDSKPKDDEEQTSKKKEPKNVIKQIVCWRAHLTRIVGIEHLESAEVVVTASTDCSVRVWYRDTGHFIGFFGQPRLWHLPSSKSVPSTPVRPYDITEVPIKTLKNLSTKSITDQESSVDCPLMFDDNRWYPFRHSAKEETRAKGNAKKFFDSLSKPKHYNSHLQSSRTGSPENGAVFRALPVYRIESPERLKTPAVAHQSTWITNQANAAQAKSQGNKPTYTYRSTSPIKEQVVSRFPHLVQANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J413</accession>
    <name>A0A6P8J413_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Unconventional myosin-VI-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116306798</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572753.1">
        <property type="nucleotide sequence ID" value="XM_031716893.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J413">
        <property type="interactions" value="1240"/>
    </dbReference>
    <dbReference type="GeneID" id="116306798"/>
    <dbReference type="KEGG" id="aten:116306798"/>
    <dbReference type="InParanoid" id="A0A6P8J413"/>
    <dbReference type="OrthoDB" id="5969357at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21759">
        <property type="entry name" value="CBD_MYO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01382">
        <property type="entry name" value="MYSc_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21958">
        <property type="entry name" value="MyUb_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000006">
        <property type="entry name" value="Putative unconventional myosin-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000018">
        <property type="entry name" value="unconventional myosin-VI isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049016">
        <property type="entry name" value="MYO6_lever"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032412">
        <property type="entry name" value="Myosin-VI_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036114">
        <property type="entry name" value="MYSc_Myo6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21521">
        <property type="entry name" value="MYO6_lever"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16521">
        <property type="entry name" value="Myosin-VI_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="14">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="57"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="931"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1090"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031572753.1"/>
        </source>
    </evidence>
    <sequence length="1242" mass="143209" checksum="1D761751D4798ECE" modified="2020-12-02" version="1">MDGGQKIWVPDVEHGFRLGTILDLGADEITVELDGLKGKTVTAPYNRVFPAEKDNSKDVEDNCALMYLNEATLLNNLRVRYNKDKIYTYVANILLAVNPYHDVKELYTKETIHKYHGKSLGTLPPHVFAIADKAYRDMRAYKQSQSIIVSGESGAGKTESTKYILRYLTESWGSGDQGRIEQRIIEANPLLESFGNAKTLRNINSSRFGKYVEVHFNEKVIVVGGFISHYLLEKSRICKQSKGERNYHVFYRLCAGAPKDIRDKLQLKKAEDFVYLKQGSIKDPSLDDVKDFKRMDQSMDNVGFSKEEKDNIYRVVAAVLHLGNIEFEEKDDAKGGCVVTAKSMNDLNTTAILLRVSSEELQMSLTTRVMSAGGADMRSDSIPRPPKQQILVPLTKEQVGAARDALAKALYTKLFDHIVAQVNQCFPFSSSSTYIGVLDIAGFEYYELNSFEQFCINYCNEKLQQFFNDRILKQEQELYNREGLGVKAVKYMDNQDCIDLIEEKRIGIFDILDEESKLPKPTSAHFTTEIHLKHKNHFRLTLPRKSPLMYHRNLRDDEGFLIRHFAGAVCYHTSQFPDKNNDALHHDLKELISDSEDAFIKSLFPGEASDDKVMGNLSIAGGGGRQGSKKLAFVSVGSKFRTQLGQLMNKLNCTGANFIRCIKPNGKMTSSLFEGGSILSQLECAGMVSVLTLMQDGWPSRAPFHEVYAMYKKFLPARLVRLDPRMFCKALFHAVGMNENDFKFGSSKIFFRPGKFAEFDQIMQQDPESLKKMVAKVTTWLTRARWRRAIWGTLCVIKLANKIKFRALAIIRIQKTIRMSNAIIKHRPRYKNVMKIRRLEVQVGTMAELASSLKKDKDVVVKQVKDVSNSINAAIVKIKSTIMTRQAMEQEYNSLVQKVNNQLNDLNKRQQQQKVAEEQERLRKIQEQMELERKKREEEERKRKEEEEERKRKIAMEIARKKEEEERKKREEEERIQREKEEKDRQLQLEKQKLLEEEQKRQEMIEQERRDRELALRLANDAEAVAAPEPVQPLQRNLPAKKDKKHDLTSWKYADLRDTINTSCDIELLEACRQEFHRRLKVYHQWKKTNKARVTPEEGAPQRAPKDIQEKAEQNKPPLPPRPAQANEPPPSLPPRRLQRFFRVPFSKRSDKYRDTVYKKQGSWFAHFDGQWIARQXELHQGKKPLLLVAGDDDLDMCELSLDETGLTRRTGAEITRQEFENLWIQYGGGQLVYQAKIYQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5L6</accession>
    <name>A0A6P8J5L6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hemicentin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116308650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574984.1">
        <property type="nucleotide sequence ID" value="XM_031719124.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J5L6">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="GeneID" id="116308650"/>
    <dbReference type="KEGG" id="aten:116308650"/>
    <dbReference type="InParanoid" id="A0A6P8J5L6"/>
    <dbReference type="OrthoDB" id="5988073at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1235"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1934"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="76"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="260"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="345"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="598"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="775"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="867"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1555"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1640"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1728"/>
            <end position="1807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574984.1"/>
        </source>
    </evidence>
    <sequence length="2174" mass="235387" checksum="359794A3553AE4D1" modified="2020-12-02" version="1">MKDGNQMISIEPGEQKTVYSPFDSRTSDLDLNVNQTDAIVTIKLTLSSLMKATDEGQYSINPLGTSDFQGGAPSSPTALSINVQTAITSSSPSIVIVNETQTPQFVCTATGHPTPSINWTRDGVIVGTGSPYNTPAVTSNDDKACYTCVAYNGVLDTKTANFCLNVQYKPKNATILSDRSTVCQNDKVNLTCTSGPANPAPSSYEFYDNGVLVRTSASNVYEATATAGLPSVNKFVCVPRNLLGTSLKNGSVEVTAKVAPAIVTSPLSTTLLEGSSLTLFCNASGVPAPNVMWIKDDGLIVGSTETFTISNVKRGDEGFYTCTASNSFECSSAAAVATVVVNYKPHLTTLTSTKTEACLNDSVTLQCTTTANPPAHEYRFYLNDQLVHTSMSGVYQLNVPQAGNNTYKSQGEDINVTWHKVGGGQVSGSGVYTIPSVTHADSGXYECRAKTGNECEVKSTMITLAVILDASVVWRRQPTSATGIQGQSVSMTWTADLASGVEWNFVKVYQKVGIGKKQMLRQHKTEGIKVYPEYTSRDADLNLTASQSGTLLTTEFTINNLNRSTDEHLYYLRIDYETSPSDSDSDDSIDLSLTILVPTTITSPNPTTVTVNQSKPAQLECTATGNPAPSINWTRNGVIVGTGSPYTTPPVTPNDDKACYYTCVAYNGILDAKTANFCLSVQYKPKNATILSDRSTVCQNDKVNLTCTSGPANPAPSSYEFYDNGVLIGTSASNVYEVKATAGLPSVNEFVCVPRNHLGTSLENGSVEVTAKVAPAIVTSPLSTTLLEGSSLRLFCNASGVPAPDITWTKLGGGIVGSTETFTISSITRGDEGSYRCTANNSNECSNVTADADVVVNYKPELTTQGEDINVTWYKVGGGQVSSRGVYTIPSVTHADSGSYECRAKTGNECEVKSTMITLTVISPPIISNIIVTEDSLTVSWNNLVLPHNTIATCLIYVMQSFHGVNWITSSNTSNEDSITCSIAELKSSTLYRIQYFLQIHKNYVNGTIYIGTSAKVNRTGASSNHSTYDTGKAGNISXGVSSTIFAAVIAVAIVVIVLLILVIVWMRFQGIQNDXRVKRQEKNQTEVPVSRSSFSTPSFDTKTVYENEGFISRQTKPDADMALYEQVQNRGRVMNQGVVGPPSFPMEYIPGSRPARHETENQVQSQLKEPSYQALDQREMAGTKHVNVNEGSYGHLLGFTRSPSQDQNHYQAMQPENRRSTQYQSLQNMHKPTFNVLIFAIHAISFFFFSDAVANTGWSYPSFVTGIQGQNITITYVANLSDHASGVTWKFVRVTKDGNQMISIKPGEQKTVHSPFDSRTSDVDLNVTQTDAIVTIKFTLCNLIKATDEGQYSINPFGTSDFEGSSTPSSTSLSINVKTAITSPNPSTITVNETQPAQLECTATGHPTPSFNWTRDGVMVGTGSPYTTPGVTSNDDKACYTCVAYNGILDAKTANVCLNVQYNPRNATILSDRSTVCQNDKVNLTCTSGPANPAPSSYEFYDNGVLVRTSASNVYEATATAGLPSVNXFVCVPRNLLGTSLENGSVEVTAKVAPAIVTSPLPTTLLEGSSLTLFCNASGVPAPDITWTKVGGGIVGSTETFTIRSVKRGYEGFYRCTSSNGDECSNVTADANVVVNYKPELTTLTSTKTEACLNDSVTLQCTTNTNPPAHEYRFYLNDHDQLVHTSMSGVYQLNVPQAGNNTYKCEPKNTVGAGKNASVTISTKVSPIIVNTTPSQEVREGSSHTLYCRVEAQGEDINVTWHKVGSGQVSSKDVYTIPSVTHADSGSYECRAKTGNECEVKSTMIKLTVISPPIISNIIVTEESLTVTWNNLVLPHNTIATCLIYVMQSFHGDNWMTSSNTSNEDSITCSIAELKSSTFYRMQYFLQIHKNYVNGTIYIGTPAKVNRTGASSNHSTCDTGKAGNISSGVSSTILVAVIATVAIAVIVLLILVIVWMRFRGIRNDKRIKRQEKNQRDVVVSQSSFSTPSFDTKTVYENEGFISRQTKPDADMALYEQVQNIGRVMNQGVVGPPSFPMDYIPGRQARHETENQVLSQLKEPSYQALDQREMAGTKGVDVNEGSYGHLLGFTRSPDNTTAAALPQDQNPYQAMQPENRRSTQYQSLQNMHKPTFNVQQHTTSKSTTARKWLLKIVIQMAEANNVFFQCYCFDIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JA61</accession>
    <name>A0A6P8JA61_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116307561</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031573710.1">
        <property type="nucleotide sequence ID" value="XM_031717850.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8JA61">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="GeneID" id="116307561"/>
    <dbReference type="KEGG" id="aten:116307561"/>
    <dbReference type="InParanoid" id="A0A6P8JA61"/>
    <dbReference type="OrthoDB" id="5974800at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000743">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="15">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="134"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="307"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031573710.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="70020" checksum="3F6B615CDCC006E4" modified="2020-12-02" version="1">MQLAIYGKRTVTIKVYMALRILNRNFTKELEDQTSPEYKDFVQNFKEQMNIVFKTLDGYAGIEILEIFNGSVRVRFRVVVVVVVKNNEYKSTVARRTVLITETVLNKAKTGRVEGLQVDKDPKFMELNKTPPPSPKNVTVVEIFKDAVEIAWDQPLNHEYYFIKGYFVEYWKFASEKEKTTTLKGQKTKVTDLESNSPYTVRIVAENENGIRGKESAQIEIRTKRPSNMPDWLLAIIIIVCIIILIAVMAILIVYCRRKNSSTNKMIEELDMRAIQKEKEADAFPKSYVNTMFSVNENCPSFARENLVLMEELGSGEFGVVFKGQLLQNGHSKECAVKTLKGTANPEDYRELHQELDIMVNVGYHPNLVNLIGSCVEDEKLFVIVEFARNGSLFEFLRKARTQPEEKLKFELNYXNRLKIALDVAKGMTHLAKRRCVHRDLAARNVLLADDFVAKVADFGLSRDIYETGEYEKTTGGKLPTRWMAIESLELRRFTLESDVWSFGVLLWEIETKGLMPHGAISFTELLKNQKKGYRLEQPEGTPDELYRVMQMCWQANPKQRPTFDQICNTLKAMLNNSQMSKGNLNEEELEIKQGSRNQQDNVDNQTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JB25</accession>
    <name>A0A6P8JB25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EGF-like repeat and discoidin I-like domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574918.1">
        <property type="nucleotide sequence ID" value="XM_031719058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JB25"/>
    <dbReference type="GeneID" id="116308598"/>
    <dbReference type="KEGG" id="aten:116308598"/>
    <dbReference type="InParanoid" id="A0A6P8JB25"/>
    <dbReference type="OrthoDB" id="5988374at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574918.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16741" checksum="6100A3F55837046E" modified="2020-12-02" version="1">MRLELYGRRYGRLPRPRIFPSGISNGRLPNKYITASSQWDKNHAPWLARLHRKRRGRLVGGWSARKNNRGQWIQFNLRSPKRVFKIVTQGRSDTNQWVKSFIIRYSVDGRRWVWYKRNSVIKVPTNFQGFVQIPWFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GXV5</accession>
    <name>A0A6P8GXV5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA nucleotidylexotransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031549094.1">
        <property type="nucleotide sequence ID" value="XM_031693234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GXV5"/>
    <dbReference type="GeneID" id="116286667"/>
    <dbReference type="KEGG" id="aten:116286667"/>
    <dbReference type="InParanoid" id="A0A6P8GXV5"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF40">
        <property type="entry name" value="BRCT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549094.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16460" checksum="42F3765EDA1C8D37" modified="2020-12-02" version="1">MASVLKRKRSDLEDHLINEVKYPDIRIYILPQRIQKTRMDILKKAACKKGFVVEESFSGSVTHVVSQYDSAEKILEALKRKSVENVELVNVNWLTACNTKGKPVTITESYRIKYSNPKEEYKPSDQQPSSNKDVKYICQRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYP2</accession>
    <name>A0A6P8GYP2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116286885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031549334.1">
        <property type="nucleotide sequence ID" value="XM_031693474.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8GYP2">
        <property type="interactions" value="2565"/>
    </dbReference>
    <dbReference type="GeneID" id="116286885"/>
    <dbReference type="KEGG" id="aten:116286885"/>
    <dbReference type="InParanoid" id="A0A6P8GYP2"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08218">
        <property type="entry name" value="STKc_Nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000172">
        <property type="entry name" value="serine/threonine-protein kinase Nek1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="282"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="413"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="512"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="635"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="808"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1010"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="817"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1014"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1157"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031549334.1"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142841" checksum="2226503A1C0C2C9A" modified="2020-12-02" version="1">MDRYVRVRKIGEGSFGKALLVKKKNDGKHYVIKEINISKMKPREREESRKEVKVLSQLKHPNIVTYMESFEEIGNLYIVMDYCDGGDLYKKINGQRGVLFTEDQVMDWFVQIALGMKHVHDRKILHRDIKSQNIFLTRHGIVKLGDFGIARVLHSTVELARTCIGTPYYLSPEIVENRPYNNKSDIWSLGCVLYEMLTLKHAFEAGNMKNLVLKIIRGSYPPIPTRYGADIRLLVAQLLKRNPRDRPSVNTVLKKNFIQKRIQKFLTEEVIEDEFSHTVLHRKPFGVPGQRPLPPKQAPVKPSAAAPKFSRPEAKYSVSVAQKKPPKKPGSGGEVAKKVVKDRIPAKLADKRKEMDARERRRKELMQNQDQMYNEHMKKIQQQRWERQQREHINKAGEQAWKSTMSVGLSPEKQAANAPKQHVVKKDPQPMNKYKRPISAQERKENIPEAPKPSRPVSAISANNVPRNPTPAWEAAMQGQMNREYAAKAAKQSRIKEEYWARKREAARNKNRGMADYGGYDYKLPEKPKAAGSNGDRNGNRNGIRGRNREEQDYLARLEAIRRQNYGERREIQRRMAGIRGPPQDRPSQKEEVKVPGDPRYDPEARRKKIAALKQQAEERAAMLRKQLDEKKKAVLERLNKAGKEKWEEEQKNMKEKPSADERPIPMKRAVPEEKPVAAAVGLETALKQVGVKTLFRSNSENDIAKVIKEMDDDEEPGMMNQHPRKKWGAIPFQPRLLPLEVTSSHMEATSAQDAVIKPGDKNSPARRQWGQQKTQIVSALENIKLQTATTTVRGIDQSDAAVKNEKGFVAQPGSPSPSIGQTTIIQKQQDVTPSSPIGQTITVSNPSPLAGLPVVTGSPATPNTVILKKPSXEETIPEEQEEREGPASVKKAWDEKPTTPSKDSAVPKSPRSPKPDDRQAYDHFVRSVIIEETKTDKIPTKDEQSAVVEDLKVEDVSVEESSFHTADGSPEKSYAVMLKTGNFDTNSRRLRTCSMPDLRLLFTTPHKNTFFEKDEDVPDNDDQQDDVGDNDVDEEGEGEGEEEEEEEEEEEEKEDDENDGDDEEEGEFGDDDEEEEELAEVSDEEEEAEEYENMLASMRDVLVSSAXSPSPMKAVGTVQSMDWDPTGDTASPTADDADGPKNDENGRSSELSNLNEDWDSGEGEVDGDEDVEDGQKEQEDDSVFQRLEESRLALEQELGFDRFLRVYKYLQAIQENEDENENANVGSSEEITELLGDKEHLYPKILYLVIADSAYNEDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2Z0</accession>
    <name>A0A6P8H2Z0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein 4B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116288161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550769.1">
        <property type="nucleotide sequence ID" value="XM_031694909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2Z0"/>
    <dbReference type="GeneID" id="116288161"/>
    <dbReference type="KEGG" id="aten:116288161"/>
    <dbReference type="InParanoid" id="A0A6P8H2Z0"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031550769.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41333" checksum="DB9935E01E93BD99" modified="2020-12-02" version="1">MPVTMENISDDEQEPLFDPEDVESKTFEKDLSFRQRLQNFVGDKRNFKATLCYCGVFMVFGMSDEVLGPTLLELRCLSGQTITIMSLLFFVHDLCNVFGSTSGGILADRFNVNLLVTIALGISAVCIILIPLCRVFAAMLLLAGIYGACFGATDTFTTFHLLRTYGKQVSPYLQALHFSYGIGGFLSPLIARPFLRDKCEYIINYTTIVDEWPYANTSSGLDNTSSVFYSQEAVPRDINVRWAYWIVALAHLPVIFGLLWLRFTVKLEKIKGELNKQDLSVYGSQTITNAGYNHHIVALYLNGKSPWLRVFGEDQKPRVIVVTVLTSLILLLFDGLMATFGAYIYSYATRGAVHMKSDHAAYLNSLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5V1</accession>
    <name>A0A6P8H5V1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289021</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551754.1">
        <property type="nucleotide sequence ID" value="XM_031695894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289021"/>
    <dbReference type="KEGG" id="aten:116289021"/>
    <dbReference type="InParanoid" id="A0A6P8H5V1"/>
    <dbReference type="OrthoDB" id="5965207at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051984">
        <property type="entry name" value="Alsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46089:SF4">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="531"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551754.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="67383" checksum="5278A71B1E8CEF64" modified="2020-12-02" version="1">MSKHGREIDWXKINGALPKPKRLHLEEDEEDGLFHCPVPSCNHDAFGTRRGCRKHVKKRHRWFYFFDEQPDVSTXTTSNSGDEKVNXTQASQSVKKIVPCFDISSTLGKEFEKWLIGSGGGCKTPKQAQQIIRKSFKFLKFCCEDDDDEEDLSWDIVDFCLSSPSFIFKFADAMQTDWGLGHAGRVGYLDAISDLLDFRKIHGTSSDTVLRNQMCTEVYLKRARKTVAKMMRLQWTNDLDIETLEAKGHWATMEELLQVITYHLPRYECVLKVCRETPDKVTPSDLSFATKFVAVYLFIKVKGSRPMTYQYLTVDMVESAKSNGGFIXQKRFKTTSKYGFDSLYLTDTSMQVLDGYINVIRPHLKPVCEYVLVTRNGSQHSKIGQLMSKLXFDATGKYIHPTRYRQIVETASRKHLESNEQCTISEDQKHSSVVARVHYQKRRSREVTTKVHEYLKTLHGEKGTELTNDVRSXLSNDLASNLLGQDSPVVXKPNSNXPAVVGNVEVTGSSSQLQREKNDFEPEPPRSTTDKPKKRKLLLFTPIEDEFLKAGLKRYGFGQWXAILRDSSYXFQEGRTANSLLNRALRKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H604</accession>
    <name>A0A6P8H604_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031551804.1">
        <property type="nucleotide sequence ID" value="XM_031695944.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289057"/>
    <dbReference type="KEGG" id="aten:116289057"/>
    <dbReference type="InParanoid" id="A0A6P8H604"/>
    <dbReference type="OrthoDB" id="5984809at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48462">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48462:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031551804.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="67951" checksum="33AAA650AC5AF0C9" modified="2020-12-02" version="1">MSQIFSEEDTDAVLLIDAINAFNQMNRSVAMHNIXITCKEISLYVINTYRSPSRLFICGGGEILSQEGTTQGDPLAMXWYSVNTSTIIQTLRTFXPDVKQVWLADDSAGAGRIVSLFNWYKNLEQEGKKYGYIVNGSKSWLIVKSEALALEAKQVFGEEVNVTSEGKRHLGAVIGSKIYKDQFCNEKIYKWKEELQTLSEIAXCQPQSAYIAFTKGYKSKFTYFMRTIESFEDYTDPVDNVINEMLLPTLFGQTEPLPEELSRLFTLSPAEGGLGMPALKEQAPQQYAASLLITASHTEAIKTQSKTMYTTTEDVKKQHQSLKAEISKSKMDEIDAALPPDILRQVTQARDKGASSWLNAIPIKEQGLTLNKQEFRDSLCLRYNIPLSGLPSTCACGTTFSVSHALSCKKGGFVAQRHDNVRDLLAILLNKVCNNVQKEPQLIPLDGEQFNLKSTSTSQDARLDIKAGSFWARGVTAFFDVRVSHVNSKSNQNKSTSTIFKDQESEKKRKYQQRVIDVDMGTFTPLVFGTNGGMGAECQIFLKHLTEKLTKKTGDTYASTITWIRTRLSFEIIKSVHMCVRGTRTPFFMDNEFLNDFNLNANVAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H685</accession>
    <name>A0A6P8H685_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Melanocyte-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116288364</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550996.1">
        <property type="nucleotide sequence ID" value="XM_031695136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H685"/>
    <dbReference type="GeneID" id="116288364"/>
    <dbReference type="KEGG" id="aten:116288364"/>
    <dbReference type="InParanoid" id="A0A6P8H685"/>
    <dbReference type="OrthoDB" id="5960696at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="37"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550996.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49039" checksum="20F04A3F496CC023" modified="2020-12-02" version="1">MSFGWLLQVCASSSAPRELSLSSTIISLVLSLVASPSNFLFCLAMYKDPHKNLRTPFNIFILNIAAADFVQGSAVLPLSAAFHGLEGVGKFSPQLLRALHLFFFISCTASIISIAALAVDRCISVSYPLKYRSKSTYSRSIRISIIIWFISAGLSFLYLQVDFILYIFVFVNSVILLTVIILLFVQFWIGRRLKKNRERREFRRPSLTNSIASMHGRNWNKMVKRDAKVTRTFFSILMLFLLLMAPSFIFAYLLNFCPSCDCVSYHVFRDLHFLFVLFPSSVNPFLFGWRLPHFRRTLRTIISRRSRNVGQDRSAGQQLESSTFEEDNSCKFYRIVNTNCSSAHKIFVIRRSKCGQWSPARDPVCDNILNGTNKTTDGVLNKSYQRYPEKEMSDLPEPQDLPPEASDTGIARDYRLTSADLLTVQMDSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H729</accession>
    <name>A0A6P8H729_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551143.1">
        <property type="nucleotide sequence ID" value="XM_031695283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H729"/>
    <dbReference type="GeneID" id="116288486"/>
    <dbReference type="KEGG" id="aten:116288486"/>
    <dbReference type="InParanoid" id="A0A6P8H729"/>
    <dbReference type="OrthoDB" id="5966402at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="230"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551143.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56690" checksum="D876D5FC53F148DF" modified="2020-12-02" version="1">MSSAGFQEELEEFFYSLIRCIEKVQECLSNRGSIPIEYIEHNLEGHFQIVSAIFVTLRENNVDQENDLFMLFQNLLGVLEELIREIDKEKEQRQHRERKGTCMVPNTLRSSGGRPMYDISKEMIENLRETGMNGKEISVCLGISESTLYLRRQCYGLQESYVDISDEELMSTVTDILQQTPYAGESYIIGALRAKGVFVQRCRIRAILQHADPIGRALRRSTAIQRRRYNVRAPNHLWHIDGNHKIIAWRFVIHGCIDGYSRAVIYLNCATNNLASTVLNFFVQGVRDFGLPLRVRGDHGMENVDVAQYMVHSRGENRGSFIAGRSVHNVRIERLWREVNRVVTRYYKDLFFFLEESNLLDSNNEQDLFALHYIYLPRIQSSLHQFVGQWNYHGLRTENFQSPMALWQTGMMSNPECFEECTPELYEIDFDSGVSGMNIDDGVVVPENLIELTAQEMALLQNLVPDPLMDDGNSGIDLYSKVCEFLKTIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H824</accession>
    <name>A0A6P8H824_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116286503 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548892.1">
        <property type="nucleotide sequence ID" value="XM_031693032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H824"/>
    <dbReference type="GeneID" id="116286503"/>
    <dbReference type="KEGG" id="aten:116286503"/>
    <dbReference type="InParanoid" id="A0A6P8H824"/>
    <dbReference type="OrthoDB" id="10034606at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="entry name" value="Schlafen, AAA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029684">
        <property type="entry name" value="Schlafen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155">
        <property type="entry name" value="SCHLAFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155:SF41">
        <property type="entry name" value="SCHLAFEN ALBA-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="SLFN_AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="271"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Schlafen AlbA-2" evidence="3">
        <location>
            <begin position="682"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031548892.1"/>
        </source>
    </evidence>
    <sequence length="914" mass="102404" checksum="261EB96C113C1693" modified="2020-12-02" version="1">MKDESDRQTKIALTKVIQESLRNPEKKNEFVREGTIDLLSELCRSKKSREIKAFALATMGVLCHGNQPAKDMIMNIGGLRTILSLCSTVEDGSNTDINTREKESRLLSHEQSAALLQKLTYKDEICQADLVTAGAIRRLIQLCDVFNPTGSHSNCCHVPSQYSDKANKLFTDLTVNKKLIGKVHELSKEESTKVIQNLIQSEAEIDCLREELNKIYNIDLYDTITEKDIHISNELITRGMAWPDLNSTSILPSEERNSPQKETKGIVWSDIRLSQVIDAGHFWAHIGGDSIGKSITAIDTFLRSQELAPYPDMPQPGDMVCVLETMASQKTTYRARVLDVSSSDEGLKAKVFAVDFGFTNVVPGMSLFILPRDPDSLPPQVSLCTLSGVQAKPKHAAILEYAAGALRNLSESNEDYISYIFMSSGIEALLKLCSIPNKKILIQVLGALMNISLDFRYRARIGYLGGVKILMDICLQYEEEDDVLLLALGTLQNIMVATVINRSRTADCHGLTIFVHLYLKTTNEEVKNRALRALKNLVGGSSSDSPERKNVLDLTAVMDECPTTQKRFSLSVTGDSEEHCKLSPRRLRTRKKRNRGMIEAKPTHISLSMDCIKKASSELSETDTSSDDDYAGRWTSETDGDTDGESLIKDLSTYTPSYSTLESPGTECENYYVQTHHMPFGEDETHEFSSQTNVHNISKRKIMKSLCAFLNNKKCGTIYIGVRGNGEISGVKVKRKERDLLRLGLDEMIDMFKPPLLHDMYKIDFIPVVRPQGSESAVTRNYVEERYVIQISLLKCTGLIYTIKGGKCYFRHKSANIELTTQEIREKTIHEQEVVYNTEIKRLRKELKGMRKQLAERTSGSDSPVPSSSPTSQPVTPETDKKSHEEVPIATTVQARTDHVKKQDECENHACVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H840</accession>
    <name>A0A6P8H840_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289817</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552609.1">
        <property type="nucleotide sequence ID" value="XM_031696749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289817"/>
    <dbReference type="KEGG" id="aten:116289817"/>
    <dbReference type="InParanoid" id="A0A6P8H840"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552609.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13599" checksum="AE893EA2BB903727" modified="2020-12-02" version="1">MLHCRFTKRSRNTSYENKTNVELESIPDKETFCSNDANXRPGIQSDASCEAVVDNASHYQSLSSATRRTVDEARPPQLYEPLIKNSKKPRQSEYASVQINSRSNPEGVVEEKNPKENATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8Z1</accession>
    <name>A0A6P8H8Z1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger HIT domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116290051</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with NUFIP1. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552889.1">
        <property type="nucleotide sequence ID" value="XM_031697029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8Z1"/>
    <dbReference type="FunCoup" id="A0A6P8H8Z1">
        <property type="interactions" value="1632"/>
    </dbReference>
    <dbReference type="GeneID" id="116290051"/>
    <dbReference type="KEGG" id="aten:116290051"/>
    <dbReference type="InParanoid" id="A0A6P8H8Z1"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048371">
        <property type="entry name" value="ZNHIT3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21373">
        <property type="entry name" value="ZNHIT3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="13">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552889.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16823" checksum="FB7E6DA5F1B43E23" modified="2020-12-02" version="1">MKSGESKRLCQICKESPFKYRCPSCYFLYCSLPCFKSHKAENICELETGKRKKESENVDTGQQEGQISNDENSEDEDRLSLSDLKKLEKCGVIESMLKNKDIRKMITNIDGAQDPEMVLRTSMKEPIFMEFADQCLSVVESKNENDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9H0</accession>
    <name>A0A6P8H9H0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC116286926</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031549381.1">
        <property type="nucleotide sequence ID" value="XM_031693521.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031549382.1">
        <property type="nucleotide sequence ID" value="XM_031693522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286926"/>
    <dbReference type="KEGG" id="aten:116286926"/>
    <dbReference type="OrthoDB" id="40118at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Roc" evidence="13">
        <location>
            <begin position="542"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031549381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031549382.1"/>
        </source>
    </evidence>
    <sequence length="1359" mass="153949" checksum="0E128ADB645FB0EC" modified="2020-12-02" version="1">MKKVKCVIVGNEDVDKKELLIRISTDLSPKKPNETSAKSSIEKVLDSTASCINEEGKEIERFKVLHNEQNVQSDDDEEEEIPDHWKGEISVEGKSYELSVINSNSEDAFQQSRTSLYREADIFLVCFSVSNLFTNSLEAVVTKWVPEIREVCPVTPFILVGTQINWRELFDPTDPSQRPISPETGALYAEKVGAVRYMECSTDDSAAVRYIFNETVRFCFMDRMELSQLHPDYVRFGTTLLHQAVQVNHEPSVEALAYVMDINVKDKAGRSPLDLALRNSNTASARCLIKNGCVVGLSNEDWRKRCEFWIDNYERLNKVHKNINELAGKLLNLYASLQDPLQSNLIVIGQHGIEVSNFLMKSAPFISIQTIAIINCQGSCSLNFSHLNYSLRTLTITNCDIGGEIPNSIFSIMNLEALSLVDNSITSVPVGLSKLKSLRRLRLSRNKIKSLPDAISGLVKLRFLFCDNNLLERLPDQIGCLGDLEVLDISQNKLEKLSVSLGLLTKLKCLKYSDNRLIFPPAEVIKQGSDEVLEFLNTFLDEPVRNTQVKVTFVGGEGVGKSTLISVLRSKKSSVLTSTDKTYGIEISDFELHHALKMKVFDFCGDPAFLVPHSLFITENSLYQVCFDMSQYAISKAAGLTINQLGRLQLWLEIIHSRAPASHVIIVATNVGHPNLTDDLRNRVREDVEEMISRYREEHKKQFEGESVAQCALCDGTHLCDVSSSHFYIEENSSRSTYPSAKPEPCVPHIVGYYEVSCKEQYPKVLLGTKNISLQKYKCNLSMKMDILLSTGYLIPHKCLYIRDRILEILNSDQHLQEQPIFTLTGVREIALGCGMKDEFKLKAMLRYFHNQGEFLWFEDISELDDVVIVKPQWLADRLRSLYLPHEGSNFINDGILRTDYLEKIWPDLSKSETAPFLSLFRGLGLSFPCSDVEELFPNLLPHGYPDRECWPKQPLPGSYQITVEFFFSFLPPSFFSDLIIAANKRELICPDLAEPSYFRFNLVFATNLKACEGCMIHNKEAQLNPLQDSSSDQKHTVHLESLPQDRTIRATVRGPSPCCVMPEIRVAIKSVSDVFYQGIKFIETFVCPTCEITKFITSKKPQYILKMKDEENICDRGHSVGSKVDIVSGRIPLEVHLTVVKPKTAIGAAVENSRNVLDDWCCPKLFIVLPIGFKSPPFRDCIVMDHVTDGHAVHFLCECPGYWHLIAAPGYRVRNLNEFFEIFGPRICKLMKLIFMTGEDNSETHTYASLKDILLKIVIGDPSLKEIMIEDIRSILDHYCNIYPNLIQGCSSFLYEDVEYLVSGKDLSRAKLARLLEIFPEGRNFGPLVCTYSERHKEKMWLCRKHAQPVSRGNQGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9L3</accession>
    <name>A0A6P8H9L3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116289430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552216.1">
        <property type="nucleotide sequence ID" value="XM_031696356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9L3"/>
    <dbReference type="FunCoup" id="A0A6P8H9L3">
        <property type="interactions" value="2056"/>
    </dbReference>
    <dbReference type="GeneID" id="116289430"/>
    <dbReference type="KEGG" id="aten:116289430"/>
    <dbReference type="InParanoid" id="A0A6P8H9L3"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552216.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55147" checksum="FF047B99E1435D7B" modified="2020-12-02" version="1">MADGGDEEMELYDNSDDDFESEESGLIMGQMDQGIKQETQIGKGKNPRTMDTTDVSNEPQETTGKKKKKKKKKKKSKEGEGSFEEENKEVEENKEIFLPGDKMEEGDELTYDSSAYKMYHAAQTGSPCLSFDVIPDGLGESRTEFPMTAYMVAGTQAAFGQQNHIIVMKMSDLYETEHEDTADSDDDEYLDEEPDMETSMIKHDGGVNRIRFSHIPNRHIVATWSDKSKVHIWDVSAQVITVDNPSSPTQIKEVSPLFTFTGHLSEGFAMDWSRNVTGRLLTGDCKHNIHVWSPQDGGGWHVDQRPYNAHTDSVEDLQWSPNEQNVFASCSSDKTIRIWDARAAPSKACMLTTQAHDADVNVISWNRNEPFIVSGGDDGIIKIWDLRQFQNGESVALFKHNTGPITSVEWHPTDSSVFAASSEDNQVTLWDLAVERDDMAEGPGHHLDVPPQLLFIHMGQKSVKEIHWHEQLPGVILSTAESGFNIFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9U4</accession>
    <name>A0A6P8H9U4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 74B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549260.1">
        <property type="nucleotide sequence ID" value="XM_031693400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9U4"/>
    <dbReference type="GeneID" id="116286814"/>
    <dbReference type="KEGG" id="aten:116286814"/>
    <dbReference type="InParanoid" id="A0A6P8H9U4"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549260.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39800" checksum="34829F868D2C12F0" modified="2020-12-02" version="1">MVPHDANFPLVTENGDFSVVILKGALLSALLDLSGNRVGKPGLTALGEMLEFNVNLKELNLSGCQIQAGSDAEAFVSSLCVNSQLKSLNLSYNEIGDSGAIRLGPVLVNNQSLTFLDISWNNIRSAGAEALCRGLSRNTSLTELDLSWNGLGNFGAECTKQTLIDNKSIRILNLSSNHISITGIKHIAQALHRNRTLQVLKIGKNPFLSSGASMILKSLLANQQSALCELTLEDVVFNEECETHLSALLEQNPTFLCTWDVTIKGGSVISGKQPEPMELLLICIHNQGFRLIDFYKILINDHTRLSLKKEEFVTGIKKRNFPFSDKQLRALFDVLDTKKGGIITFEQFIVLKNYRRQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9V4</accession>
    <name>A0A6P8H9V4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Adhesion G-protein coupled receptor V1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116289208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551948.1">
        <property type="nucleotide sequence ID" value="XM_031696088.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H9V4">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="GeneID" id="116289208"/>
    <dbReference type="KEGG" id="aten:116289208"/>
    <dbReference type="InParanoid" id="A0A6P8H9V4"/>
    <dbReference type="OrthoDB" id="6021847at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010855">
        <property type="term" value="F:adenylate cyclase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13952">
        <property type="entry name" value="7tm_classB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000017">
        <property type="entry name" value="Adhesion G protein-coupled receptor V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026919">
        <property type="entry name" value="ADGRV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009039">
        <property type="entry name" value="EAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005492">
        <property type="entry name" value="EPTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682:SF1">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03736">
        <property type="entry name" value="EPTP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50912">
        <property type="entry name" value="EAR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3682"/>
            <end position="3702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3714"/>
            <end position="3736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3756"/>
            <end position="3779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3791"/>
            <end position="3818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3838"/>
            <end position="3865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3886"/>
            <end position="3906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3912"/>
            <end position="3937"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="11">
        <location>
            <begin position="3527"/>
            <end position="3678"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="3679"/>
            <end position="3938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3969"/>
            <end position="3999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="3969"/>
            <end position="3978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551948.1"/>
        </source>
    </evidence>
    <sequence length="4097" mass="449653" checksum="046D27A69C7DEBE8" modified="2020-12-02" version="1">[encoded data, 4097 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA22</accession>
    <name>A0A6P8HA22_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289604</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552411.1">
        <property type="nucleotide sequence ID" value="XM_031696551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HA22"/>
    <dbReference type="GeneID" id="116289604"/>
    <dbReference type="KEGG" id="aten:116289604"/>
    <dbReference type="InParanoid" id="A0A6P8HA22"/>
    <dbReference type="OrthoDB" id="5984625at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043460">
        <property type="entry name" value="MEDAG/TEX26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26 ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552411.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33279" checksum="649B7B3A57B9889A" modified="2020-12-02" version="1">MRDHSTPGSQQSGNRMIRGHSAYRSTYASNYLGTLSTPVPNGRVRTSQFYPSGRPPIASTYQADFMTFPVNKRVCIPYGSSSGYRKNNPHPHNMEAAFKHPNKDYFVWSQYRRLPPLGDNDGSVDSQTLLKKVCQDKIRSIYQQDFKDPPYATAPIAYSNYRRKMGKSLYKDSYEGTFGNAADSAKPDPYEYPSKDDIGTSTYRDNFKKTKTLQLPLLPTSPTRRNNPHPSTMNNTFHFPKRGYWVWPHYLLPVKYDNGDKLPVGPRIPEDLRINRIRGPFDTWEDQSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAG2</accession>
    <name>A0A6P8HAG2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116289786</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116289786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552586.1">
        <property type="nucleotide sequence ID" value="XM_031696726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289786"/>
    <dbReference type="KEGG" id="aten:116289786"/>
    <dbReference type="InParanoid" id="A0A6P8HAG2"/>
    <dbReference type="OrthoDB" id="6088515at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="5">
        <location>
            <begin position="398"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="7">
        <location>
            <begin position="663"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="916"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="901"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552586.1"/>
        </source>
    </evidence>
    <sequence length="1471" mass="164187" checksum="10380F8B807DD67E" modified="2020-12-02" version="1">MAGTGSASTKIFLPSTLTPPTPTPKTIPKPAGAPGSSASFNLGDDQKRWLVTGICLNKVLLPALRDFVEPEMIKHYTHLRTTQNIDKQNHAKHLLKDGKCNSLNYGSINNNEVTHRKKTNLYDYDVKSAVDLAKLYLQPFMAKFTGFDDTCDLSAVLGILSSASVFSTAVQLSSSDVRKDVRNEWAHCNFGHWNGTKFAKCFQQMESLVRALNLSKAEEKRITDQLQDWETKGLQLCMGNIVDADLVKFIETEVAQLNENVKLLAKSQADEALRVSNGLQSVHEALEEYKQEIESLKESQEIISRRVDEVVDSTSAIAETVGCLKDDQENLTVKVDSIEKNQDTLTKRVDEGDEKHACLEKRVEVLETAIETRSSQEAVITFEAPNRIPCFHGRVDELEILNQPLVKKTAPCSMTAVYGLGGTGKTSLAIEHIWRNKDVYSGGVFWISGESNSLFNXSMREMARQIGTFDEDFQETLSKTISWLQQRKQYWCLVIDNLDELELSTEMLKLIGGHWKRQAKGHIIITTRREKNLLEEDICDFSKESCIELKNLSEAESIEFIKMRTGRTGXQDDAVILELVVELGTLPLALDQAAAFIKNXKEISFVQYLDEYKKQKLXILKKSKAHRPVQDDTSKDRIAVHTTWQLNFEYVSRLSEEYGIGQAAALVMEVSAFLSPDDIPREIINQGLPPVDNEDFIKCLSXSFGVTXIVSVLTKFSLFQTFTDNSFSVHRLVQEVIRSXISQEHLKDVLXXACRMLCYAFXNATSPFXVCKSFEGDSVFSQXNLPSLHLWGKLGAHASVLQKYMIQNSQXNDALXQEVLYTEESAMLLNEASLYYSVCHQKVEAMELQASKLKVITQLEELXSERLDHFRYFDIPLKSVQFKLISHCMANQEKXLSIDEDVRSSSENTEDNVQKANQLREKGNDAVRQQNYDQAINIYTEAIEYNKDDPRLYNNRAHCKLMLEKPEEALLDCELCLKLEERNGKALMRKAWALYEISKTQGEKLKGKMRAAAAFAAYVDPTARNGKRFKEMFPNLIFEEIFNPLQLAGSFMLSLPGITLLLHEGYYELHGTTIDKDLQFVALSKGVIVKFQALPILFSRFYAEGIVFAKESGGIMCQFKGTMNLFNCQVSGGFRGCKDFPDCNGGPGCVASKLAGHKPCDRTGKFGDHLGEKSGIGGSPSICITEGSTGHIENCEITDCGGGGILXQGDGSSLTVKSCRVNRNGMAGLEAREGGRLVAIDNDIYANRXHGVLIGPSAGECKVISNRIYENFQEGIFVIRTKDQVVVNSNRIYHNLAFGISLESCQVEVKGNEIFENNFYGINAKTLTTAIVENNDIYSNKCGGISIGVNFSGRIVIKSNVVRDHSGPWILHGDNSCSLPGSMASSNPDATEGLFYLPEGETRIYTLPPTVEGNEIRNNKDKAFHPKEKIESVQSQCAFCRSSXTRSTLHGRVCYASQRGLAVLQRLSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAI5</accession>
    <name>A0A6P8HAI5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RNF220-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116287029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549500.1">
        <property type="nucleotide sequence ID" value="XM_031693640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAI5"/>
    <dbReference type="FunCoup" id="A0A6P8HAI5">
        <property type="interactions" value="1661"/>
    </dbReference>
    <dbReference type="GeneID" id="116287029"/>
    <dbReference type="KEGG" id="aten:116287029"/>
    <dbReference type="InParanoid" id="A0A6P8HAI5"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16563">
        <property type="entry name" value="RING-HC_RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040178">
        <property type="entry name" value="RNF220_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="576"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031549500.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="70446" checksum="9AD57705AEB4846E" modified="2020-12-02" version="1">MMEKLGTPAYIPNPLTSPALMVLASTAEATHPTASSPSSISDYHAQYSSSNSRFIDGDTLHRMVLSTSPYQHRPSHLSLYHSQQTSERYSDRVSPDYNPHYFQIHSHLGSGLLHKTSGPTAVFNGTSAFRRISPHEHSFSFHHLQHQRSLLEREHSFESLYHKRSSLDLESERERMSKDKVSPQVTDREMGEYTNNTDHSPNASPRSTHSTESSENNPRFDTVKVKQEKEDIKECCEIAVDENQADGNRRTKAKKSGKTPCCPVCGITIRPGEMESHFAWEMEKANEEMRKTRRSQRESSIQARKGHITNKRVKQENELGIPHDDTPASTRHQTYLRVCANRMARTGHGSKSTRSRSAQSSPVNPSYLLDKNDEGPSGVRSATCPVCESVIHGSGEELNSHVEACLRKRDGNEEVNGQATFDEYEWAGQTRIRATSLLEGGFKASGFQTGIKRKNAEDDGDLNIDGDDSEEYGKAQYSESDIIPCSADEPAEDRARQALRGAVLSGENSPASRSTPTRSRWSEDEGDANHSSDEKTSSKDEKEDIEEGSNQRLVINSLKSRVKDLEKHTAMEKVKCLICMEPYSVPLVSISCWHVHCEECWMRTLGAKKLCPQCNMITSPSDLRRIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBI0</accession>
    <name>A0A6P8HBI0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550042.1">
        <property type="nucleotide sequence ID" value="XM_031694182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBI0"/>
    <dbReference type="FunCoup" id="A0A6P8HBI0">
        <property type="interactions" value="1357"/>
    </dbReference>
    <dbReference type="GeneID" id="116287497"/>
    <dbReference type="KEGG" id="aten:116287497"/>
    <dbReference type="InParanoid" id="A0A6P8HBI0"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000007">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF70">
        <property type="entry name" value="INHIBITORY POU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="11">
        <location>
            <begin position="161"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="254"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="256"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550042.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35288" checksum="64FE26631EA19E92" modified="2020-12-02" version="1">MNRDSLLNKNLSPPLSRISISNGTSLSNSYISNSGGGQFREPSWIPSIRGSNGSLSFPSRSTNLIPPSVFDAFDDSHLLSAPQPDASPKYLSKQSKQSYSIPGLHTSHAPDTYDAHDILDQISASLQPSCSVSDSFDKSFETPSPISLSAGHFHSALVPANDDMNPRELEWFAERFKQRRIKLGVTQADVGTALAHLKIPGVGSLSQSTICRFESLTLSHNNMMALKPVLTAWLEEAEKAYKTKQMNSAFLPNSDKKRKRTSIGAAEKRSLEAYFAMNPRPSSDKISSIAEKLDLSKNVVRVWFCNQRQKKKRMKFSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBY7</accession>
    <name>A0A6P8HBY7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone chaperone ASF1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553151.1">
        <property type="nucleotide sequence ID" value="XM_031697291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBY7"/>
    <dbReference type="FunCoup" id="A0A6P8HBY7">
        <property type="interactions" value="2514"/>
    </dbReference>
    <dbReference type="GeneID" id="116290286"/>
    <dbReference type="KEGG" id="aten:116290286"/>
    <dbReference type="InParanoid" id="A0A6P8HBY7"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553151.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17772" checksum="07DF4F05940A6B21" modified="2020-12-02" version="1">MAKVNLCNVEIKENPASFIDPLEFEISFECSEELNEDLEWKIIYVGSAECADYDQVLDSVLVGPVPIGRHMFVFKANPPDPSKILDQDVIGVTVILLTCSYKDREFIRVGYYVNNDYADVEMRENPPAKPVISQLQRNILVSEPRVTRFNIKWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCZ3</accession>
    <name>A0A6P8HCZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P2X purinoceptor 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553521.1">
        <property type="nucleotide sequence ID" value="XM_031697661.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290591"/>
    <dbReference type="KEGG" id="aten:116290591"/>
    <dbReference type="InParanoid" id="A0A6P8HCZ3"/>
    <dbReference type="OrthoDB" id="5972251at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="1">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="1">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553521.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23127" checksum="F25979A48939DF74" modified="2020-12-02" version="1">MSSSSSSDFGDYFEEIEQQEGLIQGFMFEPRRIVDDFSESDISSDSSNSATHDNRLQNSDWCQCDNCQIMDREVECLCCREIPQIMEKNRQVVEEEHLAEPLRCITDNPGFKAVCLNRWVLXAAWFHYRQQYGAVHTPXHKRNRHVAYRQLVRWCWGVFGKEIRVVLPSCAVMCIRAHFPPPGLEDDFEFSGFHYPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDS1</accession>
    <name>A0A6P8HDS1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein ceh-19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554569.1">
        <property type="nucleotide sequence ID" value="XM_031698709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDS1"/>
    <dbReference type="GeneID" id="116291210"/>
    <dbReference type="KEGG" id="aten:116291210"/>
    <dbReference type="InParanoid" id="A0A6P8HDS1"/>
    <dbReference type="OrthoDB" id="5981035at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554569.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30429" checksum="E5FDC74AE1025805" modified="2020-12-02" version="1">MENGNISNENLVPRFPTPPLESENKPSDPKPSRKTSFLIENLVAEKASVTEHGIRKTVKRKYEFLEEKDEKENLKEFSVLKDVQDNPNEIKMSAGELLLLNKKPRTSFSTEQIRELEKRFETQKYLGTKERAELAISLDLTDTQIKTWFQNRRMKLKRYYQASMESSIEKFPSFNSASGFGFGIPHALPSAPILYPPMYPGYQSLLAPFLGGDPTGAYFSRPRILTDVDHPSQASSMVHPPLENRSPWSYAPLLAPYYEVPMYAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDY2</accession>
    <name>A0A6P8HDY2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Collagen alpha-1(II) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116290918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553896.1">
        <property type="nucleotide sequence ID" value="XM_031698036.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553897.1">
        <property type="nucleotide sequence ID" value="XM_031698037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDY2"/>
    <dbReference type="GeneID" id="116290918"/>
    <dbReference type="KEGG" id="aten:116290918"/>
    <dbReference type="OrthoDB" id="10072310at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553897.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="21990" checksum="81743D96623F21AE" modified="2020-12-02" version="1">MKTKPVENNSISSLLTTALAAIKRMEKKVKLLERKMDEQTLTIVKLQTQMDSSNGTTSGVVGPPGPRGPAGPRGLTGPAGPPGRDGTQGPAGARGIQGPKGHPGYNGTQGIPGEPGSANLTACVYQVAKSAGATAGNSAKTEVEIREPRDQRIVGATCSTNDAEVSILSSEVSQVTNVRSYKCMCSGSSGLLPSANTPMHCYIHYWICPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGI3</accession>
    <name>A0A6P8HGI3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial amidoxime reducing component 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554073.1">
        <property type="nucleotide sequence ID" value="XM_031698213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGI3"/>
    <dbReference type="FunCoup" id="A0A6P8HGI3">
        <property type="interactions" value="943"/>
    </dbReference>
    <dbReference type="GeneID" id="116291096"/>
    <dbReference type="KEGG" id="aten:116291096"/>
    <dbReference type="InParanoid" id="A0A6P8HGI3"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="163"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554073.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36299" checksum="26A058402BFC0AFD" modified="2020-12-02" version="1">MVIQSKYLVFSLSAVAAAVAAAVAYMRWRKKQRKEYHVVGHVSGLFIYPVKSCRGIQLESTKCLSHGLKHDRRWVFLNAKGNFISQREQPSLALVTPSFKLSDDGEVECLYLDAPNMETLKVDLPLNTEEYKNIDVFGIVGEGQSAGEEAAAWISKYLDKPGCRLLHMTKPRVLQTDTIWGKYVATPDDKSGFGDFAPVLVATTEALNALNKELENPVNMKRFRPNVIVTGTSTYDEDNWKKIKIGDVEMRYLKHCDRCIMTTVDPERGVKTGREPLHTLRRIRMPANRDKRYANAPFFGLHITVEKEGEIKVGDDVYAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGP8</accession>
    <name>A0A6P8HGP8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554128.1">
        <property type="nucleotide sequence ID" value="XM_031698268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGP8"/>
    <dbReference type="FunCoup" id="A0A6P8HGP8">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="GeneID" id="116291146"/>
    <dbReference type="KEGG" id="aten:116291146"/>
    <dbReference type="InParanoid" id="A0A6P8HGP8"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554128.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30686" checksum="C40DD426A28B0AA5" modified="2020-12-02" version="1">MFTLTARRVSQGLHRNIYFSALRSGDFKFASSCVLNSAKRTLLSNCRQTDKLCGSSLSCLWRSPPSNVFIVWGCRSSSSTSTSTSFSGSVFNRNKTTLVYVGAVVLTVLGFSYAAVPLYRLYCQASGLGGTIKQAESGEKIEKMERQADRILRIQFNADTSKSMRWHFKPQQSHVKVAPGETALAFYTATNPTDSPITGISTYNVVPFEAGQYFNKIQCFCFEEQRLNPHEQVDMPVFFYIDPEFTEDPAMAKVDTIILSYTFFESKEAEKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGU6</accession>
    <name>A0A6P8HGU6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC116289037</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC116289037</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551773.1">
        <property type="nucleotide sequence ID" value="XM_031695913.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551774.1">
        <property type="nucleotide sequence ID" value="XM_031695914.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551775.1">
        <property type="nucleotide sequence ID" value="XM_031695915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGU6"/>
    <dbReference type="GeneID" id="116289037"/>
    <dbReference type="KEGG" id="aten:116289037"/>
    <dbReference type="OrthoDB" id="5945899at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653047" evidence="1">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="388"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551775.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="50328" checksum="F683FA2D5510F6AB" modified="2020-12-02" version="1">MWCQVLIVLAVAMPSAQANNSFFKNFGVFDIEPGHALDGHVIKSLPLFKADCMETCKETLSCFSINTYKDQHGNNLCDLNRSTKKQSPKSYSKRVGYDYSEPLKGEFCLKDDCPTKEALPDNWYKFNSSSYKYFINTTNWDGARKHCQELGGDLASFSSETENEFVFKTMLHDLNITNESNTSGLYPHLKFNGTDAGLSLIGAAQFETKDSKPAVSFNGTSYAEIPRFDLHSTDFTIAVHVFPRTASSAEQILLEGFTGSSSIFEIGIDSMNSSGISIATTNSVIKVYYKGIPNQKWTHIAFTWNYKTGVVVPHINGQRSSSTASTSPSPKSFRAMDPFYQIGKGLDGWMSNMVVVPRILTSQEIKDLFNGAISNITDTQPSILQGAWVGLNDKATEGIIQWSDGLPLTYKPNEELGNSEKKDCGLFIKINGDESAWKTEICQANATYVCKKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGV8</accession>
    <name>A0A6P8HGV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SCO-spondin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116289083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551832.1">
        <property type="nucleotide sequence ID" value="XM_031695972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGV8"/>
    <dbReference type="GeneID" id="116289083"/>
    <dbReference type="KEGG" id="aten:116289083"/>
    <dbReference type="InParanoid" id="A0A6P8HGV8"/>
    <dbReference type="OrthoDB" id="5945005at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027805532" evidence="5">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551832.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28930" checksum="BF9259D63DFAAFE1" modified="2020-12-02" version="1">MIYFLLLVIVAKQSTCASFHGLDSSCSPLDCKVNHWSLWSECSESCLGIPGHQTRFRNQLQAHSCQGLPCPALKETRSCLGNRCMNDGVLNSQGKCVCRESHTGKCCNDRVLGWGSWSSWSPCIKTCGAGCTSKRRTCYKGPEANCTGYGVLMKVCNKEPCPLEKLRFEGLGCFDENEPRAIPILVKNLRPDLDWWHLDKTVITCAKMVKQKGWKVFGIQFYGECWSGPSALDTYAKYGNSSACWDGVGQEGANYVYFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH92</accession>
    <name>A0A6P8HH92_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein regulatory complex protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116292107</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the nexin-dynein regulatory complex (N-DRC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DRC12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555216.1">
        <property type="nucleotide sequence ID" value="XM_031699356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HH92"/>
    <dbReference type="FunCoup" id="A0A6P8HH92">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116292107"/>
    <dbReference type="KEGG" id="aten:116292107"/>
    <dbReference type="InParanoid" id="A0A6P8HH92"/>
    <dbReference type="OrthoDB" id="10264405at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033585">
        <property type="entry name" value="DRC12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28656">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28656:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031555216.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23636" checksum="1653DAB34A32EB76" modified="2020-12-02" version="1">MPPKKKKGKGKKKKKKDEKTELTVEDKYKRTIQEIECLRDELASRTEITRRAKDTTLRMKEKMLEAQDTVEAEKQNKLDISSDLTRQYKTMQSEMALRIHMLEQTVTKLRDNLAKSEEELRRTRKEFEDMKKEKDQTIAELKFKIEHMESVYESILHDAFDRMSAKVEDARGKWQTQALETQEKNKQLLLEFGLNPLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHI0</accession>
    <name>A0A6P8HHI0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552030.1">
        <property type="nucleotide sequence ID" value="XM_031696170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHI0"/>
    <dbReference type="FunCoup" id="A0A6P8HHI0">
        <property type="interactions" value="745"/>
    </dbReference>
    <dbReference type="GeneID" id="116289272"/>
    <dbReference type="KEGG" id="aten:116289272"/>
    <dbReference type="InParanoid" id="A0A6P8HHI0"/>
    <dbReference type="OrthoDB" id="6435999at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031023">
        <property type="term" value="P:microtubule organizing center organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029711">
        <property type="entry name" value="Haus7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010604">
        <property type="entry name" value="Plant_AUG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14352">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14352:SF2">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06694">
        <property type="entry name" value="Plant_NMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552030.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39484" checksum="1856A5640DE88C23" modified="2020-12-02" version="1">MAASSSASQERVAFFRKRLEDLDCPYIDGVDDSWIEELLYKPGEPRLRLIQWLLGRFDPTVHDVLEGQQSKAKEDARLQRLLFVCNLLGLCKPDDIELVKGSTSKGRQIVFMENMIDLVGTVDSMDTYSRTKGISVAESISDQFARDCQYLDTLCRQEDLSEIFKTRIQLSPPDLAKGGSRSDDKRVPDNKQLANVADQLATELETQNLQLDNLRNKVCVNEADPQTKEKVSKTLNLALTTMSQVVTGFLYCYESEMKPWSNRSQPNLSELGPAFERVYSLLEKFLHLLEGFSSIKSSHTSMCDKTKTQLQNTKDGSLAPMSKDTLENLQDCVTVLEESIQRYQEQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHQ2</accession>
    <name>A0A6P8HHQ2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA demethylase ALKBH5</fullName>
            <ecNumber evidence="4">1.14.11.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alkylated DNA repair protein alkB homolog 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC116291459</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18 19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031554487.1">
        <property type="nucleotide sequence ID" value="XM_031698627.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554488.1">
        <property type="nucleotide sequence ID" value="XM_031698628.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291459"/>
    <dbReference type="KEGG" id="aten:116291459"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032860">
        <property type="entry name" value="ALKBH5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32074">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32074:SF2">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="16">
        <location>
            <begin position="88"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="254"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031554487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031554488.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37490" checksum="3E3510EB468EB559" modified="2020-12-02" version="1">MKDLREKLNKNQGKQQQNYDTTRKRSREGSFAKHSSNDVNVEIHKVQQGIKQRILFDRQECDTIEAKINEVVEQANSGEFKEKTVDRAPLRVKYFFGEGYTYGKQLAEKGPGGEKLYPKGEVDEIPQWILDLVVSRLVKARIVPKGFIDSAVINDYQPGGCIVSHIDPLHIFDRPIVSCSFFSSCSLSFGCKFIFKPIRTSPPVLSLPLPRGCVTTLSGYAADEITHCVRPQDVVSRRAVIILRRVHPDAPRLEPFTVKPYYDNPTNDTTNQQEPVTHDTPSPDTCDTSKAQDTDNDEETENPVQHSPKPKKRRIVLQRGYKLQGSNKXPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIR2</accession>
    <name>A0A6P8HIR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Protein unc-93 homolog A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116289671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552480.1">
        <property type="nucleotide sequence ID" value="XM_031696620.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552481.1">
        <property type="nucleotide sequence ID" value="XM_031696621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIR2"/>
    <dbReference type="GeneID" id="116289671"/>
    <dbReference type="KEGG" id="aten:116289671"/>
    <dbReference type="OrthoDB" id="78663at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17406">
        <property type="entry name" value="MFS_unc93A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000290">
        <property type="entry name" value="Unc-93 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031552481.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="61116" checksum="FE3CCE4DAEB99A1A" modified="2020-12-02" version="1">MADENDEAKLQKNNENKPDEQKKDSQEDKMEKKPAGDVESDTMRSSDLEDVDLADEITEPSTALSPEECKKERFKIFKNIIIISFGFLFLFTAFQSLQNLQSSLNPDQGLGLASLSVIYAALILSCMFVPPFMIGRLGCKWTLVISMISYVLYTVANYYARWWTLIPASILLGASAAPLWSSKCAYLTTTGIRYSELGSEDKDSVVTRFFGIFFLVFQSGQIWGNLISSLVLDKGGSSFFREDAGEVCGVHFCKSPPKQNLTNGSISFDTLEKPEYSLVLKLVSIYLGSGVLAILLVIVLLDRLSGHLSRKKDEVSGLKLLFATLNHLKDRRMQLVLPITFFSGMEQAFIFGDFTKAFITCSLGIHKVGFIMICFGVTDALFSFLLGRLTQYTGRVAIFMSGMIVHLTVIILMLAWSPRADLVWVFYVMAALQGYCDAVWQTQINALYGVYFSDNQEPAFSNYRLWESLGFVVAYAYSNYLCVRVKLIILLIILILGTVMYLASEFVHRKFVQEIALDTGEGEEHALQPLKSTNVQTENTHLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJM4</accession>
    <name>A0A6P8HJM4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thrombospondin type-1 domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116289975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552795.1">
        <property type="nucleotide sequence ID" value="XM_031696935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJM4"/>
    <dbReference type="GeneID" id="116289975"/>
    <dbReference type="KEGG" id="aten:116289975"/>
    <dbReference type="InParanoid" id="A0A6P8HJM4"/>
    <dbReference type="OrthoDB" id="10358971at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028215349" evidence="4">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031552795.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27042" checksum="C9F70842E1AF15ED" modified="2020-12-02" version="1">MDRYYKWLACLLGFLCITSNQALYRGPWSAWSSCSASCDGSQERTRTCQAEQGESCEGLTSESRSCSSGVCVNSSIIVAIVFGLLILLAIIVVIYLTIKRRKTLRENEEAAHFNTNAAEDYYDRSIVRSSSIGSRANTAAPSIASSRATIPTIAPYLPDVEEEEHVPQNYNNYAYDNTDSLGRVSFSNESIQEARLDFDVDEVEAVHESSSPAEQPKVTMMTFAGTQTELGDDNNDDDLAVTIDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJP1</accession>
    <name>A0A6P8HJP1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116293323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031556599.1">
        <property type="nucleotide sequence ID" value="XM_031700739.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HJP1">
        <property type="interactions" value="3296"/>
    </dbReference>
    <dbReference type="GeneID" id="116293323"/>
    <dbReference type="KEGG" id="aten:116293323"/>
    <dbReference type="InParanoid" id="A0A6P8HJP1"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000642">
        <property type="entry name" value="Serine/threonine-protein kinase srpk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="84"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031556599.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="69548" checksum="BA75348B856FEEA2" modified="2020-12-02" version="1">MNSKIQRKVLAAQSKKKRSKPLKGKMKPDDGKAKGNKSGSVSSYNDDEYEVDENSDDEEQEDPNDYCKGGYHPVQLGDLFNNRYSVIRKLGWGHFSTVWLAWDTSDQKFVALKIVKSASHYTETAIDEMKLLRTVHTADVNHPGHKHVVQLTDDFKIVGINGSHICMVFEVLGHNLLKLIIKSSYRGIPISIVKSIICQTLKGLDYLHTKCKIIHTDIKPENILLCISERQIQQLAAEAVMAKDTGIYSPALISTAPASVMQQSCETKISKNKKKKMKKKLKKQIEKQKLQQDEIEQCMLQECEEDCEADCEETSTTENVRDECVEESSKELCQLQNESEMNSDNEAPSELNNELEEEFIEELSSKMLQEQCVVSDEDEKQQQQQQNKLNTEIEKPSINGDDNSSDLMEEEPPLDQKASISPYHESTEGDQEEVDFDEDDIRVKIADLGNACWTHHHFTEEIQTRQYRCLEVLIGAKYGPPSDIWSTACMAFELATGDFLFEPHSGEDYSRDEDHLAHIIELIGRXPKHIALSGKYSKDFFNKKGELKHITKLRPWGLYEVLTEKYEWPHKEAEELKSFLQPMLDYNTERRATAKQCLEHPWLRDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK40</accession>
    <name>A0A6P8HK40_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555258.1">
        <property type="nucleotide sequence ID" value="XM_031699398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK40"/>
    <dbReference type="GeneID" id="116292142"/>
    <dbReference type="KEGG" id="aten:116292142"/>
    <dbReference type="InParanoid" id="A0A6P8HK40"/>
    <dbReference type="OrthoDB" id="5975019at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555258.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28136" checksum="1A22EAF316203F22" modified="2020-12-02" version="1">MESPTRAKTRTRSQILGELLRVKKEMERGPSIVGKQPTLKAYTPDTSNDLASYYNKYIVDYMISDQEDYVPRPGWGMRATSLKIVEPEVTWRMDNFPGPVYDSVVPRGYYKEGLWSKNLSGLDPNQGSTRLPPIPKVKFPKLNNDNYRHFKMNYDHVKPFRAEVKNVQDSKYKRRMQDDYKRTVNDWNRMNLAEIYQLPPQSSYNVKKAIQTYLGASKGCHKALNPLLKDMTPRGSICSSKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL54</accession>
    <name>A0A6P8HL54_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116290456</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553345.1">
        <property type="nucleotide sequence ID" value="XM_031697485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290456"/>
    <dbReference type="KEGG" id="aten:116290456"/>
    <dbReference type="InParanoid" id="A0A6P8HL54"/>
    <dbReference type="OrthoDB" id="419198at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027700607" evidence="2">
        <location>
            <begin position="28"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="3">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031553345.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57719" checksum="9A4DCCA106BA5B4A" modified="2020-12-02" version="1">MARMLPRSKKTIFIFLLIGNSSFYVYQQFGGQNRTKKERSPGIQQDTSGQEESLGMSSGENGRGYVGDKHGMKWRPVLRKGAHFEMDSSNLDVRXKAVPVKLDSINNQAKKLKAKYTGGKNVAEKRTHRNRNDEFRKTKPNRVNRGRKQXNRXSNEKKRSPRRGREGRKYQKNQPNGGTDGKNPPGRERGDVTNYSGETHDKSRIHIQYGEVNTRKVKPVKPINDLQQDXKIENKQQNKKLCNITFEYGQMCPTLYTDLGGYCKIDKKVPGGFDCPDIRRKGYNKLRSTQLVLTRLLKIFDLVARKHDIKYWITSGTLLGAARHRGFIPWDEDADIEMTLDEYIKLFKCCKNDFPEGIFFQSSETDPYLKSQNETENRLLRHPVVGLYRRLWNPRLRDTKSRTKFCLAYGCGWADGLMIDIFIAEDTMHPYHLSRVFPLKEMLFEGFRFPVPGNWRKILQYKYGDYNKELGEYDERIPEDNSDPFHSCEELKQANNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMK2</accession>
    <name>A0A6P8HMK2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557584.1">
        <property type="nucleotide sequence ID" value="XM_031701724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMK2"/>
    <dbReference type="GeneID" id="116294176"/>
    <dbReference type="KEGG" id="aten:116294176"/>
    <dbReference type="InParanoid" id="A0A6P8HMK2"/>
    <dbReference type="OrthoDB" id="192748at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557584.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11922" checksum="BBF239DD79314461" modified="2020-12-02" version="1">MADQGGKIPVGKGIPSQKELLKPLIFPNNQRAFRLFNAALATGITVYFVFFHKFPQQDHCFVPIRNLVESQKARFLRIKPEDEEYIKRRTEELSKARQSETNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMP6</accession>
    <name>A0A6P8HMP6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kynurenine--oxoglutarate transaminase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556293.1">
        <property type="nucleotide sequence ID" value="XM_031700433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMP6"/>
    <dbReference type="FunCoup" id="A0A6P8HMP6">
        <property type="interactions" value="1370"/>
    </dbReference>
    <dbReference type="GeneID" id="116293035"/>
    <dbReference type="KEGG" id="aten:116293035"/>
    <dbReference type="InParanoid" id="A0A6P8HMP6"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="84"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556293.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52510" checksum="F1AEE836A408EEA3" modified="2020-12-02" version="1">MLVWSVKSCRSLVRSRLVKERSFLLGCFQTIVRGSPVCSNKIAAEVFQARDMSTSKTLIPAQRVAEKPLNIWQELTDLARIHGKVNLGQGMPDFNPPHYVNDALSQAAQSADVPMQQYSRGQGNLRLTNALARMFSKLHGREINPMTEVVVTVGAYEALFDSFMAFVNPGEEVILFDPCFDCYYNQIRLAGGKPVYVTLQQKKGATTAKDWIIDRASIESKITDKTRAIVINSPHNPVGKVLSMEELEMIADICIKHDLLCISDEVYEWLVFNGAKHTRIATFPGMWERTLTISSGGKTFGVTGWKVGWIIGPENLIRSVQAVHTDVTFHVPTPIQEAVATCIERETPLLGTSESHFAQLAELTTKRMEKIASFLTDFGFVPMIPEGGYFMLADFSKVDTGVDLNEYDKSDDPVDYKFIRWLAKEKGIALVPPSAFYGADNKALAGTNVRVCLMKADSSIEKAAELLKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNI2</accession>
    <name>A0A6P8HNI2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556573.1">
        <property type="nucleotide sequence ID" value="XM_031700713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNI2"/>
    <dbReference type="FunCoup" id="A0A6P8HNI2">
        <property type="interactions" value="708"/>
    </dbReference>
    <dbReference type="GeneID" id="116293303"/>
    <dbReference type="KEGG" id="aten:116293303"/>
    <dbReference type="InParanoid" id="A0A6P8HNI2"/>
    <dbReference type="OrthoDB" id="6021576at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="33"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556573.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35503" checksum="F404C1381ED59827" modified="2020-12-02" version="1">MNGTESRLTSRSTAIIAAETSILLLIGLITFVGNLLVVISIYRNPSLRTITNYFVLSLCVTDILAPLLGLTPILAWSIRNHFFEVFGEGTCIFQGLLTTGLTYISVITITLMAVNRFIRVCKPDKYSKLFNKKTSLIMIGALWTTVFTLELVALYGRKENKFAFVKFLEHKLTCGLMFNRDQKSSRTIGTLTLIFILLVPFIIIFFCYFKVFKKIRQHKRSIAPASNPRSLGTSVQEIKVTRTLFAVLIGYCFTWIPVMIVTLLSNLFGSRSLPRQAHMIVTFSGISSSAINPVIYGILNRTFRHEYQRIVCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNM6</accession>
    <name>A0A6P8HNM6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-splicing factor ISY1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557979.1">
        <property type="nucleotide sequence ID" value="XM_031702119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNM6"/>
    <dbReference type="FunCoup" id="A0A6P8HNM6">
        <property type="interactions" value="2409"/>
    </dbReference>
    <dbReference type="GeneID" id="116294499"/>
    <dbReference type="KEGG" id="aten:116294499"/>
    <dbReference type="InParanoid" id="A0A6P8HNM6"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031557979.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32570" checksum="75344EAF64836E8C" modified="2020-12-02" version="1">MARNAEKAMTMLSRWYDVKRKEAGKGVQERRPFLATECDNLQEAERWRHQVIREVAKKVAQIQNAGLGEFRIRDLNDEINKLLREKRHWEDRIKELGGPDYGKIGPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEQEPPKAPRKTRAELYKDVDADYYGYRDEDDGVLVPIEQEVEKDAIARAMEEYQRRKEEEVDEEEEEEEDIYAVQAGEEASDNEMETEEGAEGEQTFVSHVPVPSQQEVEQMLVHRKKMELLDKYASEALIQQSQEAKALLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNR3</accession>
    <name>A0A6P8HNR3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556673.1">
        <property type="nucleotide sequence ID" value="XM_031700813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNR3"/>
    <dbReference type="GeneID" id="116293390"/>
    <dbReference type="KEGG" id="aten:116293390"/>
    <dbReference type="InParanoid" id="A0A6P8HNR3"/>
    <dbReference type="OrthoDB" id="10275410at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556673.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11088" checksum="952A863FC3536B63" modified="2020-12-02" version="1">MRGNVLPQVTQSIPEYEAVQQAIGNPSAHGIVFSSSGDASQYQELNLLAPGSPPEGLGPTYEPLRTKSKDMESVAQQEQHPYESLDLKNKSSAYQSLQTINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP06</accession>
    <name>A0A6P8HP06_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 14 homolog A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554380.1">
        <property type="nucleotide sequence ID" value="XM_031698520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HP06"/>
    <dbReference type="FunCoup" id="A0A6P8HP06">
        <property type="interactions" value="2367"/>
    </dbReference>
    <dbReference type="GeneID" id="116291345"/>
    <dbReference type="KEGG" id="aten:116291345"/>
    <dbReference type="InParanoid" id="A0A6P8HP06"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="523"/>
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        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="698"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="192"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="470"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="472"/>
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        <location>
            <begin position="487"/>
            <end position="505"/>
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        <location>
            <begin position="614"/>
            <end position="624"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="709"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007774"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554380.1"/>
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    </evidence>
    <sequence length="726" mass="82951" checksum="4F556878B69AA3E8" modified="2020-12-02" version="1">MAAKEALKLVATVNEDSDVEVDDQLLSSSDNESDGQEESRHSNVIKIIKNLDKKSSKRKRNQRSEPNLKVSEFHLSSGGDNEKIDIKDLIGSLQKEGQYGKLKKKLESMEKNAATLDVPLPQLETNKIQRTIAFEETSKEVGKWQPIVKKNREAEHLSFPLNPYKPPEITTKSLSVTFKPRTPLEQEIAAVLNGSSHLMERKNNELTEEEEQALLAMDLEEAKERRSELQRLRALQSYYEEKCRRAKKIKSKKYHRIKKKSEQRAASKLSIEELQLKDPQKAAEELEKMDRIRAEERLSLKHRSTSKWAKNLLIRGHKNPEAKKAIQEQLELSRKLTEKQQVHTESDDDDDDDTNAIDPSSMFGNLKADSNNPWSLDTNTRHEKTTGSVQDNETTAGFKRIPAINVQETTEKANNESEDDSESAEDNTEDDFEIKVSNKPKKGKKKSKKRKTKDQDWIEKETPKKKESYKSKVNKVKTKVKGKSKDEEEDDLLEILMPSDEESNNDNEKPPTSVETFNTSHAKGKSVIVDPNKIFQMEEYNSNKVLTDNTDNSDHILNIQQAFANDDVIEEFVREKEEAMESSKGKDLDLTLPGWGDWGGPGAKVTSKKKKFVKKAEDPPPRKDRNLAHVIINEEDDKRLAKLQVKNIPHLYMSSEQFEKSIRNPVGKDWNTGSTVKQLIKPRVQTLMGSIIEPIKPTKNLKRSNAHSSVDKKRLKKKDEGLTIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPH3</accession>
    <name>A0A6P8HPH3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC116294113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557506.1">
        <property type="nucleotide sequence ID" value="XM_031701646.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294113"/>
    <dbReference type="KEGG" id="aten:116294113"/>
    <dbReference type="InParanoid" id="A0A6P8HPH3"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000007">
        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
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    </dbReference>
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        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="ATP-grasp"/>
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        <property type="entry name" value="BC-like_N"/>
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        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
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    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
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        <property type="entry name" value="Biotin_carboxylation_dom"/>
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    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
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    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
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        <property type="entry name" value="CPAse_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
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        <property type="entry name" value="Single_hybrid_motif"/>
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    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098:SF0">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23335">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin carboxylation" evidence="13">
        <location>
            <begin position="854"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="973"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="1445"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557506.1"/>
        </source>
    </evidence>
    <sequence length="1534" mass="171973" checksum="D47E1872E4224B33" modified="2020-12-02" version="1">MRLKIHLQKESKHTDLVSCVGWTTSDELFSSGDDHTIMKWNLLSGETSQLIKXAQDIYPTDFHWFPKAAGGVKQSQIDIMVMTATDGKFHLISRNGRVEKSVEAHRGAVLSGRWSYDGSAMATVGEDGQVKIWSRSGMLRSTLMQTGTPVYSVSWSPDSDQILYANGKQLVIKPLQAAAKPIQWKAHDGIVLKVDWNPINNLIISGGEDCKYKVWDSYGRILYSSSAHDYPITSVSWAPDGELFGIGSFNTLRXCDKTGWSYSLEKPNIGSIFNIAWSTDGTQLAGACGNGQVIFAHVIERRLEWKNFEVTVTERKSIAVRDVMNDTKETLDFRDRIIKTALRFHHLVVATSSQCYIYSVKNWNTPMIFDLKNGNISLIVLAEKCFLIVDDAGVQIYSYEGRLISAPKIQGLRTDVLXEQTVSLSNDTIAIKDRKDEKLIYLYEALSGKPVGNGQPLTHTMEIIDIALSQCGPTSDRQVAIIDKNRDMYLAPXKHIGAAGKFVRLGTMITTMAWNDTTNMLAAFQDGKFTVWYYPTAVFVDQDVLSKTLLEKDSSDFGKNSQIINFLENHCTMRRADGSLCNAIISPYPAMLHKYASESKWEDAVRLCRFVKDSALWACLATMAAYAKDLNTAEIAYAAIDEADKVQYINHIKEIPTKEGRNAAMAIFCRQPQEAESILLQAGLIYRAIQLHIDLFNWDRALELAVKHKTHVDTVLAYRQKSLENFGRKETNKRYLQYAQGVEVDWEKVNAKIEMELQKEAARPGAKPYSGLMTFLPLMYFNPCPPVLINTLNKIIGGNSVPPNLYRNCFAHLRGFKMAANVXGREFWKRWLDCGRNSFWRSVITRSKSTGIKSVDKVLIANRGEIACRIVQTAKKMGVRTVAVYSDADRNARHVEMADESYHIGKAPSSESYLKMDKIIEIAKATGSQAIHPGYGFLSENPEFAEMCEKENIIFIGPPPLAIRDMGIKSTSKAIMGDAGVPIITGYHGDDQSAARLQEEAERIGYPVMLKAVRGGGGKGMRIVNSPKDFDSALESARDEAKKSFNDDDMLVEKFVERPRHVEVQVFGDKQGNTVYLFERDCSVQRRHQKIIEEAPAPGVSEEVRRSIGEAAVKAAKAVGYVGAGTVEFIMDKDQNFYFMEMNTRLQVEHPVTEMITGLDLVEWQLRVAAGEDLPLMQEDIKLNGHAFEARLYAEDPEKEFLPGAGPIHHLTTPQATQNVRIDTGVRQGDEVSIYYDPMIAKLVVWSERRSSALRLLKESLSQYHIVGFNTNISFLSTLCNNEHFKEGDVHTDFIKEHFQDLFPAKQSISKEALAQAALSLLLLENNHREMKRTTFNDKFSLWNSSSGFRLNSEVSRRIRLNDGDKKMELFATYNKDGSYTIEIEGDRFDVKGELQQEGNRTNLTATVNNKILKSSLVDQDGTIHLFTKDGCHKLDRPVPKYLRGTTMSGTSGGAKAPMPGSIVKVLVEPGQQVEEGEVLVIMEAMKMQYSIRAPKAGKIAKVLCQLNGSVDRNAQLVQFVEEDEKKDEEEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQI5</accession>
    <name>A0A6P8HQI5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable E3 ubiquitin-protein ligase HECTD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557373.1">
        <property type="nucleotide sequence ID" value="XM_031701513.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HQI5">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="GeneID" id="116294001"/>
    <dbReference type="KEGG" id="aten:116294001"/>
    <dbReference type="InParanoid" id="A0A6P8HQI5"/>
    <dbReference type="OrthoDB" id="5986060at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043366">
        <property type="entry name" value="HECTD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="2260"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="2712"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557373.1"/>
        </source>
    </evidence>
    <sequence length="2712" mass="301907" checksum="4CB5E86998CFE763" modified="2020-12-02" version="1">MTTESSLDNETWSTVTEQTILLQDGLKFVADLVSAPEFDSNSLSTFVDCEFRFESSWIAKLAQRLQAVLCMQSSPYQLYFDFRQRTILSLWLSQRKRLKTCKKGDVNGDISKTAVEKRKPVSFSSHVSLLLLLPLLESQSKIDPSLPISCTELLLHCLREYSPYSLSSEPRSCLDGLERLLCSWLDIEASKQTQSAEVYVSTSRREDIVAALIALACGRLSLKSLIQVLLILQKHRTSLHNISTHEVLQRTLTYTRTGKHTPPTLLKTSNFVSRWHCKPFPDSSSNVQNDEKCTSIACDGKFLYVTCSGGKGLAKIGTGRMGSFRGLLYNINLSIAAGWVVWNHGFLIFRPAVFDTNRKVFCFMLDPSTLKIKCNVEFKDSLAITNQDQVCQVSTVQLTSDGVHLYWIFTLSSMPTDQPQEPQQDQSAYDLCIWGFRLEEIEDEKTMSQKIVAVPLTPHHMTIDLGRVDENDAAGLKQAAQTPMNVQFKMSNLGLARNNLSKIPMFVASDMLVLVLPHYSLTNNKGHLVLRAKRNPINCCFSLVDDHCIIRESLIDTDNSVDSWQDFGITRLGVCIDPMDGAIWTYGDGHVCEWTNTGYPSMNQVKDQLAITNDPFGPLEGDQMDVNNVISSIAIKITILSRSLEAQLSALRPVNPDTFTEALLDSNYLTLIYEALHLGIVSKNHTIILTVLHALQPLLQLAVTRRIKLENQLVKDLRSLVWMLVCTSTESYSRQIHRQACRVFVRGLSVFYRGSKEQSALLMVLLSDTDSKSNGIFLMREMLLRDMAAKLVNTEKYVDFPNRLAYDVECKLIKACVMVSTTDILQCVNLAEDDLAKFLAAQPDVSASLQYITTLVTKTWKELMLSEDCTMESSLVEMSEFVTKNVESIMLASKILEASQELLEVVLEALQKLQNNSQEVVWSRLDGLEKVIKATPVGQLLLFMVTIMANQKFCSLPLAKSLLSRVTSTTITATKAANLFHHMRAAANSKSDDSVLMPTLQSSLPQLTPWTHSCIVESIHPIRDDYRYSKTVTFKGAKCLYLKFDPRCATQYEYDKVMVYAGPNTTAAKVGEFGGNVYGYGSKGVIRLGWPKDFITVDGDSVTFVFQVKSTRERTTPDKAVWGFACSVSLKKGHNKDEDVALPVLTDVALGLSHLNYKLLSVLYDGPATISEEEACSHLLNSQLLQRCIWEESEGMSLQESQANGIKITITQDQDQPPTTTPKVLPRQPLSTELTKRIRNASGILAPTLRPSIRHALEPEAIEEVVLSAVIRHLNLYDKVHGLELLQVANADSTEYVKLCEVMREVFRRIDGILRQLQAMAEVELRWSQEIEDLRQGLLQPSAAFFNEYHLQEVKSKDLELLCSLKGIVFDPMEQERVVGKLIQLLENEAKSRTNDDSEDLLERMPKTRALRHSIIECGELLCSVTIQSPLKKRGPPGRSVSHGTFVPRAQDYEHQLSDTSSVNRSFSAPTQLHRSMSVREGAQDLRRLQRWRTAIQKKKQTHDVGSKPDTNEDNMELVSIMDDIFAFIGSDPDKEVSYSSFLSAARLRNERGLSRVQALLHMHELIGVCANIPGHVPQLIITIASILSQGPRIEELKCGGMATAVREEFTNVVQALLQQASTDPIVYSNSILVLSVCPFSWQEERCVIRSGLISLLDRLCILGRDQSQSSRNTASMAWASFQVLLDRFVQWENDDGYQADEIEWSGLAYQVSSLITNYLNFVLEESRKEITRARDSLQYILKLLQSIAGSKMGEAILQQSCTVSTLLAVLLDPRAPPKLVLTVLKLCRAALPLMTTNSCEQLTLPVTAERYLNRDDNAADLKPVLKVAKLLLAKLGDFILPCVQNGKRLQYGKNGNCNGGVEGTANDTEKTEQYIVYVHKRSDQPSHEVVQTIVSHIGHRFVFRVGLGTEVDRAVRLDHELTENNKAVIMTDVFSACVTKASSLAAMGLVTSVLPAYHRQQESFDKGLVSSENVCSVRNQILASESCRPFVSGQVAHTMASEVISLLQSLLTSPSSDAAKLWSSAVKQVLSDALNSVSSLMERLGKEIDRSIMHQGQETEEDEETLTVAGEELMMVSGQVMAALCSMGGFNHTVYAGCNAKIIGEDMVAMTCEVMSTSDGMATILLDDSTQAERLLDIPLVRLELPHKEPVSLNKVELVEQAIESLYLILKTRDVTLPKIPESEDSNALLLETSAARVLCELKTRASMVLTCQMKDPVFCDAFTSHHSQPLQTMKALADLTDPGKRLAVLDSQCQELRKLFKDLVKPVDRRHNGKTKPVALDIRKEYPPIKGVVFTEGYRVAHMMVEGENIQNLPRGAYLYATQSIPLKAPSYYWEVEILSLARTDTSNYVGSGSSLSIGIAPTISHPADKWATPVGACVLHDNGIAVHYKRGGFTNWETTNTGLTIQNTHVIGCSYTRSEDDVDHGSVYFTHDGQRLPGVLHGVRAGLWPVVHLQRKDVKVRVNFGSHPFVYAKGSKIRQAADLASDSMEEVRQLLLELPFAGVENDSDEEARVMAPIKEVGETKLKKIPEPLSLSSDTDIREYDPSASLTYMLSSSCDVMTDTGPLSHMEEDDSQKQILDSKNASPTELLVKAWEENVFPVISRRFRNEADRRSGLEQIRGALQAGMMDIAVATLEDLYEDTGGIPNTLTLPRLEDVKEDANKLSVSNIRQGMAVVVSSKLNDTSMAGFAVPEMKRTYGLTGIVLTIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRA1</accession>
    <name>A0A6P8HRA1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555160.1">
        <property type="nucleotide sequence ID" value="XM_031699300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRA1"/>
    <dbReference type="GeneID" id="116292057"/>
    <dbReference type="KEGG" id="aten:116292057"/>
    <dbReference type="InParanoid" id="A0A6P8HRA1"/>
    <dbReference type="OrthoDB" id="5951880at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555160.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32431" checksum="DBBE143C16A91331" modified="2020-12-02" version="1">MLFCHLGRILRRTQWNCTLKVSRTTISRSSAKFSNSDAGFCEALDCIKTKLEPLKKTQIFLGTGQYYAHEANERIVVLSLGESGSLDAPLELLDTGIPSEDIHKLEKEIIKLPQCSLLASGEVDSVHEEPWNFGFIRKPNFSIFCKFGYNVIIKELNAGPAFRVFNGPLFEDVYLRNVMNLQIKLSEEPWHERKLELLVKNGEPLTVLEDLREEGLKDLGEVMTSTEWMVKAAGYMCLMARQIGNSPRVSLRLPEELRADMNPWVDLRNKAWIDRINDDEEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUG0</accession>
    <name>A0A6P8HUG0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292993</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556232.1">
        <property type="nucleotide sequence ID" value="XM_031700372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUG0"/>
    <dbReference type="FunCoup" id="A0A6P8HUG0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="116292993"/>
    <dbReference type="KEGG" id="aten:116292993"/>
    <dbReference type="InParanoid" id="A0A6P8HUG0"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556232.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27565" checksum="1A462CD7BD27E0F2" modified="2020-12-02" version="1">MLERLETLNEKVALEKRVEGLQETLRVKEAEYVRQTRLLTNAERQFSHQDARMEEMVKQLDQALRARDNAERELEEARRTHTPTAVLEETLRERESSYQRRLLELGKSKDEDISTIRREVEKTLDERDAARRAFHLALQDLNMSQEEVKDLQTTMEGSLVERRQLVAEIKIKEEQIQQRTSAIEDLERNISEKQEIIADLSRPEEEREAARREAEALREEVAELRAEKDKMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW25</accession>
    <name>A0A6P8HW25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031556835.1">
        <property type="nucleotide sequence ID" value="XM_031700975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293531"/>
    <dbReference type="KEGG" id="aten:116293531"/>
    <dbReference type="InParanoid" id="A0A6P8HW25"/>
    <dbReference type="OrthoDB" id="5957406at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556835.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="44228" checksum="8BE3BB31052DEF68" modified="2020-12-02" version="1">MAEILTSETILKVVLRTIFGIPIAQTPRNQLRYGIFHNLLSALLLTSIWGAFCYDMYCVKTYWRSSLRPHIPIETLLLLIPLNLSGAVTYTLMVWFFYSNDFQHSHTRLVVPHFDFMPEGHQEDIGPTRNDWKYVNIFLLFGVIIVILVLVFAFVFNVFFDFDGIHNFTIHIHDLKRDLYYFDIAVIYWGFAGSVVACCIFFICCRDIVRHIEFTKTLIVTKAKNYLTARHYHECLLRYSDDVMNTTKLWFVVHSLFFVFIVLTDVFVWIMAFSEIRHQPHNLIPILMGQVXGSSLIAFKFAFPFLAASRVTARYDRMYRRINRQWRPDNLSEVDAFMSYAIRCEAGFTLFGIKLTAELALISLLSXXLGFCRXFKNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWU7</accession>
    <name>A0A6P8HWU7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminopeptidase N-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557067.1">
        <property type="nucleotide sequence ID" value="XM_031701207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWU7"/>
    <dbReference type="GeneID" id="116293747"/>
    <dbReference type="KEGG" id="aten:116293747"/>
    <dbReference type="InParanoid" id="A0A6P8HWU7"/>
    <dbReference type="OrthoDB" id="6018855at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557067.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21664" checksum="47726BED7F520CD9" modified="2020-12-02" version="1">MQLIVLYSITPALRQLVYYYGVRQGDQKDWQKVLEAVQTTTVPSEIQPLLMGLAGSSKEDALLNYLKLGQNQSIVKQQFAKYMYDFVANRNPVGHKVALNFILPRADLMGHLPVVSKRFSTTYRMQQLKDYIEKNLNGEEMLRQFKKALELVRLNGAWLEAHEKDLANWLDWYTVKYNLAADDGLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYI9</accession>
    <name>A0A6P8HYI9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Liprin-alpha-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116294266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557687.1">
        <property type="nucleotide sequence ID" value="XM_031701827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYI9"/>
    <dbReference type="FunCoup" id="A0A6P8HYI9">
        <property type="interactions" value="1849"/>
    </dbReference>
    <dbReference type="GeneID" id="116294266"/>
    <dbReference type="KEGG" id="aten:116294266"/>
    <dbReference type="InParanoid" id="A0A6P8HYI9"/>
    <dbReference type="OrthoDB" id="2132119at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000004">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="882"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="974"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1150"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="306"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1150"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557687.1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137897" checksum="118FC68052EB6FA3" modified="2020-12-02" version="1">MMCDIMPTISEDPPEIQYGQNEETNFEQLMVNMLDERDKLMETLRETQDTLSLTRSKLNEAQKEKESLMAHLETVLSEGDEQLIDKLATLDGINSDSSNNLKEDHENNHVRRIAEDFASMLKELNQSREQLLEKEEEILELKAERCNTRLLLEHLECLVARHERSLRMTVVKRQAASAGGVSSEVEVLKALKSLFEHHKALDEKVRERLRQAVERGNSLENELEDSKDKIRQLEQENENIRIRNLKRLTRHEDDGLQDMHLANGENNDNRKQMSNGPMDPTLSAGCLHDEQIDELQFLLTKRGKDIDRMTRESREFKEKATLLEEDVRITNKQLERATNQIQKLERDLDEAAAQKSDMEDRIATLEKRYVRMQHEVTALNDDNERLETELAAKETELIQAEEKQRSYQERLELSEQNLNQLHRKAEALPKIEEELAERMAALNKAAEKQGSAEEQVTKFKTQVEELQAELKRAREREKMNEDHNTRLSATIDKLLTESNERLQAHLKERMGALEEKTAVTQELEAMKAQVEDLQKEKEILARELARIKEERRQSQETKELVERATQSMGPGSASDVLYREQRGRRCLEENPSQVFTLNEQEWQKMEQENVLKNITIAFDTTRPSDSTALDFDDNEGSEVAGDALTLASLLQQQIDAINQELNYLQDEHRTTEEKTDELVKSATGSTGPRRLSGANEDYLSNSTSSFPFPPLDPMDTTPIWVKSSKDGSLNNLNDDSPTPPTPSSVASDSTESPKTSITSPVPDVISTAVNNNGNSKLKYEIKDNSNDSLPSATSTSTTSSAESLTKTQSANKKKGIKGSFGRLFGSKGKGRSKDPSSAPDSDSVSMDSVTTGNGQRELDRGIKKKSHLLAEALEAGTPFGLWNAPTVVAWLELWVGMPAWYVAACQANVKSGAIMSALSDTEIQHEIGISNPLHRLKLRLAIQEIITLTTPSSPHTNRNSLVYGEMNHDWVANEWLEHIGLSQYKTLFEECLVDARMLDHISKKEYQKYLKVVDSFHRHSIQCGIKCLSLLNYDRRVLEKRQHLSQGEPKDVMVWSNQRVIDWLKSVGVNEFADNLQHTGVHGAVIALDDGFDCNALAYALQIPSQNTQIRQILDREYTCLLCSGTDRAVANDLGDGEFKRTKSWRKVFKSKDKSKHKEKDKEKEAVRKSSSGSESSLSQCSSSSSPKSTSKNYKNIESKKTELKSMDAGSFRKGKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYQ4</accession>
    <name>A0A6P8HYQ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pleckstrin homology domain-containing family G member 4B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116297430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561514.1">
        <property type="nucleotide sequence ID" value="XM_031705654.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HYQ4">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="GeneID" id="116297430"/>
    <dbReference type="KEGG" id="aten:116297430"/>
    <dbReference type="InParanoid" id="A0A6P8HYQ4"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13242">
        <property type="entry name" value="PH_puratrophin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF3">
        <property type="entry name" value="PURATROPHIN-1-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="813"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031561514.1"/>
        </source>
    </evidence>
    <sequence length="1379" mass="159219" checksum="23875CFED4182709" modified="2020-12-02" version="1">MAAEQLEEDDWNWRTLCQDFHFTSHVPSLEKIEQEHYGGDTKKFIQEYLEPVFCLLKDIKQSAEEYFSSGKDGPEDAWTXYYESFVQSVIQVNKLTSPLHKGDFYIHLSSIVPGQMILKYHDSGNVQSLPLGKDDLWKIWNNTWTDQLRMEMNGRFLFLNCVVLSKNGKFERRPWRYLMAPSRNISFKQYRSIEKEDNLXESCKVSSQSLVLDKPLHIFEVNFELLHTGVACLPGCKDMRGGHILFINPSRPDWNNVQYSTVELTRLLMYFQTIPKKQEPNLGFTIILDARKSATKRRLIEDILEAMICFQESCPGAIHMVYVVARKDSPLLMFSTTKIKEQLNFEFKIITTVQDLKKVIDENQLTPEFNGTFHYDHDEWIRFRIKLEPFMTGCRSAAKLAMEVMQQFTSTKVGETLKDCKSLLEQHQQKVKDVFLDSRLSALQVEGEQILIRLEEEETSLAKTEDYEETVECVSKLYHQMNEVFCKLEMLTENRTKKLEQCVQLREFECDADKVETWIRTEAESFLHKHTELGDSLHHVQSLQEEFDIFEKNAKSYLDQIENVLEESRSLYQGNHYESTGLQERCKALEDANKEVNKKMEARRAQLALCGEFHKLVEEVSKWTLSTLKQIALMKMEEILTLDGVAVLTKNLDEYLEKYPVWPASQLNRISEIATNFGDSRMVSQAEGVLTRYKEVEDMLEQRKGTLRRAEERLRGNPSCEFSSTTTGGSDESSSTPHDGDEDENDLGPDTDDEMDTPVAENPDVSPERKISGDRNPMLYTWKEVSSIQPESPPPLESIEECEQNLSPKVKEKLSYIVQEMIDTERDYVKSLEYIMQNYLSRMENPDLLPSLRGKKNILFGNIERIYDFHNRCFLRELEMCQEKPLQIGSCFLKWERQFYLYALYNKNKPRSDQLLSDHGNTYFKAFQEELGDKLDLGSFLMKPVQRMCKYGLLLRDMIEACKDGVRVNELKDAQNMVRFQLRHGNDLLAMDSLRNCDVNVKEQGRLLRQDNFIVWSGKKKHQRRVFLFDDLVLFSKARRQQGGVDLFYYKNSLKTADLGLTESLGDGGLKFELWFRKRKTGEKFILQAPSMEVKTFWLSEITKILWKQAMRNKEYGLTEASTGISVESQPALHIPTTRYDETPHYQASVSSLHHHGPLLRKTSNNTSNITATDKRLSLISSETDSSASSGFCDAATHTTEEEGASAKGIVTTVDSRVSSKAQRSPRGHRRKKSMEEVPNKVTKDIEKGQEKKNKQSKSPSPEEEKKSSNFFRSFSLRDRSSNERATSPEECGGGVVLRRSVREKDSNGPHKRRSLIERITHKHSEDKTKEKEKSRRRSLVETCTVSLDTKTDGKENATDSTHNKQGVKSKSNCVVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYV8</accession>
    <name>A0A6P8HYV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cholinesterase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560588.1">
        <property type="nucleotide sequence ID" value="XM_031704728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYV8"/>
    <dbReference type="GeneID" id="116296669"/>
    <dbReference type="KEGG" id="aten:116296669"/>
    <dbReference type="InParanoid" id="A0A6P8HYV8"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028387475" evidence="6">
        <location>
            <begin position="18"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="19"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560588.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="67118" checksum="28A6E5D564D1997F" modified="2020-12-02" version="1">MFALALLVLHIVVFGSARNVVRTKQGHMWGTRQDIQDYKGLIKPVYKFLGVPYAEKPIGNLRFKRPQSLKSQRVRIYNATYFRPICLQNNDYYGKSILTAWPGFDHEKDMSEDCLYLNIYTPSITSCKKKYSVIFYIHGGSYVAGTPVRDISPGEYLPTRDVVLVTVQYRLGPFGFFTTGDSEAPGNMGLLDQVEALKWVQRNIEGFCGDKNSVTLLGESAGGSSVSLHYLSPLSEGLFHRGIAVSGVDFSPFAYNPKSVVLKGSNKLAETLECGRKTSEEKMKCLRSLSSSIILNKSASLHHMSPFVDNHFLPDEPEKLRKNGKFHKLPFMSGFVSQEGAHILQSKNFTNYNLHGFKEDLKEFLSRQYHDQYKNSYTSAAYNALVFQYTPWVDVTDSHRIRKKLIDLNTDYFIVAPTHAALTLHSDHGAPTYMFEFAHRSKYHPKPEWMGVVHEDTTAYKFGLPLLSSPRSMLSFDDDEDRNVSDLMTTIYLNFAKFGQPTPTSVYGTQWEMFNSSSKAYLKIKKNPFMTSKYHPIRIAFWNSYFPTLLSKQPLPPSIEGSKTSGVVAFRGSRFVFIIFIGTLGRILGWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I141</accession>
    <name>A0A6P8I141_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette sub-family A member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116297376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561453.1">
        <property type="nucleotide sequence ID" value="XM_031705593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297376"/>
    <dbReference type="KEGG" id="aten:116297376"/>
    <dbReference type="InParanoid" id="A0A6P8I141"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000327">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF268">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1203"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1287"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1315"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1350"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1413"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="520"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1479"/>
            <end position="1711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031561453.1"/>
        </source>
    </evidence>
    <sequence length="1896" mass="211115" checksum="B379E709317DDA67" modified="2020-12-02" version="1">MANRFRQFRLLLWKNFILQIRRPVGTVFEILLPILLVAILILPKVFLEPTNICFDTFEPTSSLSIPSSIIKQQTIALAQEGKILTANQSLVLAYYPLGDPVASLMRKVSQTTGIKAVNYSVVHGEKEFTSLDQIIAEATEHEDRYFGVVVFDLNKGDPLPKKVKYSIRLSHSSAGDRKTWLTERTYPNFQTRGARKDNFYLSRFVPLQYAIDMAIIQEKSNLPTPIPMNVQQLPYPSYVQDPFVQTVSGLLPFMVTLAFIYSAVSIIKEIVFEKQQRLKESMKMMGLENWLHWLAWYTKCLLFLLISVILVTLVIKVFKIFEYSDGFIVFLFFLIYAAASISYCFFISVFFSNPTLSMLFGLALWYASLLPYQIFAQNQNFDLLSKSAKAAMCLLPNSALGIASTLFARLEGLKLGMTFETINQSTSPDDTFNMAWVFMMMIISAVMFMILAWYIEGVFPGKYGIPKPFYFPFQKSYWCGFSHDDIIEANATDKELGPVENKDQDHHAVEDEPTDLQIGVGIKGLRKVFKSSAGTKVAVDGLSLNMYKGQITALLGHNGAGKTTTMSILTGLFPPTSGSAHIGNKSILTDIDGIRESLGLCPQHNVLFDRLTVKEHLEFFINLKGKYGQAAKDEVLAMITDMQLLDKMNEKSATLSGGMKRKLSCAIALVGGSETVFLDEPTSGMDPYARRATWDLLLKYKAGKTIILTTHFMDEADFLGDRIAIMADGQLRCCGSSLFLKSRYGVGYHLTLVKEKDFNENTTINTVKRFVPSAEILSSVGAELEMVLNKDAAKSFENLFLDLETKKQEYGIASFGVSVTTMEEVFMKVGEGAEKTVDDIVSDHEHHKDTENIVTIPNETDPDMGELQKGFAHKWQQYKAMLVKRFLNSKRDKKAVVTQLIMPLVMVLFGLIIINSNPARDSDLPRLLKLSNLSVGGVNSKAFFGYFRDVNASTKASYLSAAKDFLSTVKVDTIDVTDSVNTIQSKNTLNGIQVQGTSYNYSSPVKDKLSPCCNYEFLILNAKCQKDFTDKSLKASNCSSNEMFGYKSECDTCLTQTKLSCNPKSIQQTILSDKNTYFIEHVLEESDSKDFFNKHVAGFTIGPMTYTVIAPTNMSGGNMSSSNVSSGNSSLPTNKTGPVTTMPPNPSTLWYSNQAFHTVAEALNAMSNIFLRELTSKEHEIETTNFPLPNTAKNKSENVTGSFSMLFMAIFLAMGMAYMAASFIAFLVQERASKAKHLQFVSGVDSFCYWFGTYTWDYLNYLIPALFVLVIFAAFQVESYKNDMGAVFLLLILFGMAVLPFVYVMSFLFKSPLVAYALTVFILSILSLAMLLTVFICRLPGVDLEEEAEIMHYVFMIFPTYTLSISLVDMNSNYENRKICTETPENQAGCAFAGVKYTDSSLSWEMPGVGQEVLFMFIEGIVLFIVTLIIQSNFLMSFQRKKSQNSANSQKQPTEDEDVYAERMRIAQLNKEQSSKQAVVMKDLTKIYRGSNMVAVNHLNLGIPRGECFGLLGVNGAGKTSTFSMLTGDQSISDGTAFLDGYDIQTHLKQVQQRIGYCPQFDALIERMTGREMLVMYAQLRGVAPDKIDEVVSATIDHLSLGKWADKLCGNYSGGNKRKLSTAIALVGNPPIVFLDEPTSGMDPVARRFLWDSLTSVMKGGRSIILTSHSMEECEALCTRLAIMVNGQFKCIGSPQHLKSRFGYGYSLMIKVKGDINTNGSIATASEVIPQVPSVPSAAYTNPVATQGLPSVHGPGHPPYNAVANQNPPANGDVAYLPPPPPVAPPNLETIMLQPPAVYYDNGLMEAVQKAQAFIDQAFPGATLMESHNGMLTYQIVNEDLTWSQIFGQLERNRESLNIIDYSVSQTTLEQVFINFAKHQHSEERTKVKKCRCFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2Z7</accession>
    <name>A0A6P8I2Z7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559200.1">
        <property type="nucleotide sequence ID" value="XM_031703340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295508"/>
    <dbReference type="KEGG" id="aten:116295508"/>
    <dbReference type="InParanoid" id="A0A6P8I2Z7"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027701093" evidence="1">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="152"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559200.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27579" checksum="6FFFE34589E85AD4" modified="2020-12-02" version="1">MYEVILVYILVLGTLCWSLAPQNFDHEVCGSWKRYGNSCYMRVYDKVKHTDADISCRGNDAFLVEVDDXLEQRFVFEHLVRVPYPEGVWTGLVRVTNGSEWTWNGRKPLKFNFWGFGEPNDFMKQGEKCSEMRSWDGKWNDVLCLNRLSYVCEKEIKVGQSSTMSTDISRMNGALTGHVILATNATGVMDCYDKCQSIPQCLSFNYEHSTSNPLRTCELNNSTRGLVGQSFVPSDGFTYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4X1</accession>
    <name>A0A6P8I4X1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">THO complex subunit 5 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116296145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559967.1">
        <property type="nucleotide sequence ID" value="XM_031704107.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4X1">
        <property type="interactions" value="2163"/>
    </dbReference>
    <dbReference type="GeneID" id="116296145"/>
    <dbReference type="KEGG" id="aten:116296145"/>
    <dbReference type="InParanoid" id="A0A6P8I4X1"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031559967.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="78845" checksum="63747F7147B5A7EF" modified="2020-12-02" version="1">MKRRKSRTMSEPETSPQGKKMTKSQSAHVVKDKVGDDLAHVDDLEEALSDAGSDVVSFRKASEEIKKLIEEINDLKKEGKKAESPEINERRIRCTLLFTILKKLNRLAHVRCKKSRDSTQEAKQKVDELLLELQNLLYEVMHLKKEITKCLEFKSKDEEIDLVSEEEFYNDAPKEFSKPEVTKNDPHQRMLARLDWELEQRKRYASQKEEFTKRKDHLALEIKAKKEFMDSLQPRLENILKATLPVQEYLNLPLDAQRAQYETAKYLPLPLYVLYVQSTAYHEACDKNLDIQIQGDLDAAKAVLEEKPIMRTDEESDSDQEGTEDATDKRRSKRRRMKEKSRQLEAKKALLKNHPLQVIIRFTFKSKDSLSLTFSYLPTLNIVTATPSLSLVEGGEMPVLASRNLLSPXSILDCLLPGDHGNSLPNPTNQFQLAKVGISDFSCIKEIGKPFLWAQKICGLEFLPDVTAVSAKSQLSSSHMEETILAIRARILARLALQKQLASLEGCKIPDIKGNSTLFPHKIQSALKSWKPLTYADFVEIXFAKNLVTEDLISESDMFFTAQFQRDSKEILEVVVVVHQDYPVKPPLFSLCVKTSEAEISDEMTRSMEAEVNVHYQDLMTLDSPDNILTNQMKRLQMCFDIFIGCGYPNNLKDTEKLKSEKMLVRGLKGRERGLPFKYDSSLSIYTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I576</accession>
    <name>A0A6P8I576_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 7">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPK1 type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 7"/>
    <dbReference type="RefSeq" id="XP_031559915.1">
        <property type="nucleotide sequence ID" value="XM_031704055.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I576">
        <property type="interactions" value="2693"/>
    </dbReference>
    <dbReference type="GeneID" id="116296093"/>
    <dbReference type="KEGG" id="aten:116296093"/>
    <dbReference type="InParanoid" id="A0A6P8I576"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031559915.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="59760" checksum="3B05B09636E659FD" modified="2020-12-02" version="1">MGLEEKMSDISSWFYRGEGNDTMVVGLRGQNLVLRLKKRYRQKTGSIKDQNYSMNGSAEQHDNSLDFSKNVFLPLMGGKYVRVGEIVRLPHGFAAQLDIVCEPFRPKHRLHKGIDTSAATAIAMADFCHLPEDIPWNPHLGVTEKVQDTRVAENASSKPTFSVEIKPKCGFIPFSTYIKKEHFVKLSTCHYCMLQRMKVAEGKYPRPSQYCPVNLFSGDISRVFCALQSLVFDPQNNLRIFKDGFPIFTEEIAQDAIKNEGVCCSAYVLERNLINCGWTQVSIPTHLQSSLETHNCDTLGLCSNSFMKNVLQILVHDSNITSHKIPQTTEFHNQVCEGQGPVSHIQDTFKENKXVMTFGRGGVLAWLHLVQRMDDVDVEGLFPLYIKINKYFEHNPKERGIFSVDGPYDTGIWTDVSRSNSVDKAHGIHLPKLNKIESWSTRDIVFKICQFAVASTAKDCSMMLTFQRHHNQPKHLPFIEDDTCGSKVYILYNIDLVDLDPKEFDRVQKYYSDSCNAVRHYLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I863</accession>
    <name>A0A6P8I863_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rab GTPase-activating protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560885.1">
        <property type="nucleotide sequence ID" value="XM_031705025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I863"/>
    <dbReference type="FunCoup" id="A0A6P8I863">
        <property type="interactions" value="3545"/>
    </dbReference>
    <dbReference type="GeneID" id="116296915"/>
    <dbReference type="KEGG" id="aten:116296915"/>
    <dbReference type="InParanoid" id="A0A6P8I863"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01211">
        <property type="entry name" value="PTB_Rab6GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000007">
        <property type="entry name" value="Rab GTPase-activating protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="6">
        <location>
            <begin position="196"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="609"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="878"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560885.1"/>
        </source>
    </evidence>
    <sequence length="1102" mass="126258" checksum="71E198994861D8DD" modified="2020-12-02" version="1">MAEVEKAVSSNGNDSCPESPEPRSPHSTGEQDFILLSTPEIESDTGSVLSSGKSKSQGSSIGSFADVDTPKAEATIDKEFTDEEVKELVEDARKETKDDISDTSEKDCTNRYSKDSGIGQSSETLKLDDVVDSSNESSVLQNDELKRKRAATDMTNSKSIEIVDDTIDGSLRNRAGTDPGSGEEEGIDEDAVEFTKVTYLGSSTVDAPVSEIELKRTMTILREQSQVTIDVILVIGSTSEGKIRLMDPETKTDIATYKVQKILFCGRGDVDSEERDCFAFNTVHGEPDIFHCHVFKCLEPEMAGKIFKCFAVAFRKHRKPLDLQHGQRVRSPTDTQPVLTTLNNLSFKFDVSLDIQEEDSKGYSSVSRDKVCFKLRQNVKKKVVVTVQQLTNRHLIVERCFGLLICPGRNVRHSDMHLLSGITTDIQDGGRVYCISGYWNPSAQDLLVLNTETPKDTRVFMTIAIDLVVAKVTDPVRFIYETKARIFPANERLWYLSRPRIHDTYIMDLQEAVNEDTGEKGYEVKSIVSEKELIARGQMFKRQSSYNQQTTNDKNSEDDEDDDEPLLSGSGMVQKECTEEELCSWSELLSKWKDVSTKPRQLYSLVKKGIPEPLRGQVWQMMAGVEENDDLLQNYRHLLKRESPTEQVIVWDIHRTYPAHEYFKEIGGEGQESLYKISKAYSVYDEEVGYCQGLSFFSAVLLLHMPEEQAFAVLVKMMSEYGMREIFKNEFQMLHLRFYQLERMIEDSMPDLFSHFQHNNVEAHMYASQWFLTLFTAKFPLPMVFWIIDVILCVGTDFVFQMAIALLKDARKDLLQMDFEGILKYFRVTMPKRYMEEERYKQLLASALNIKVTHKKLKKYEKEFVILKEKEAQLEDPVERLTRENKRLMETNMRLEGENDNLAHELVTTKVTLHNKLLEAEEEIDALKTQLQLNRKALTETEDERESLKTEGKQLKDMWRKSLQESEDERKRHTAIIEEYKKICSQLDERSQKLKDDLQQELVEIKRRIGECEKCAPLFSEEGQTSQEGGANDGFKTSVKVVDAEKRLRELELELAETKLTLVETECRAQELEHKLSSFIAAVAIEESKPWFKRKSVILDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8D3</accession>
    <name>A0A6P8I8D3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116299735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116299735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564313.1">
        <property type="nucleotide sequence ID" value="XM_031708453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299735"/>
    <dbReference type="KEGG" id="aten:116299735"/>
    <dbReference type="InParanoid" id="A0A6P8I8D3"/>
    <dbReference type="OrthoDB" id="5977329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031564313.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23524" checksum="A6238A5CC3932084" modified="2020-12-02" version="1">MSVPNIYPIQTTNGKALKVYCDMTSEPGMVWTLIESFALSAKKKFQAAPMTKDFPSNEENPPNWSDYRLSXNTMQHVKRDATHWRATCNYDTERLVKTDYIRGHLSEMDILTYLGSHTCARVEYINVRGISCQNCTTHFRQTSALHSFVDSGYGSKLGCQWDGRPGGVHNIVDDWCDNFGRYNLINPXHRCSSSSSSTTQWWLGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8K5</accession>
    <name>A0A6P8I8K5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen alpha-1(XV) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564388.1">
        <property type="nucleotide sequence ID" value="XM_031708528.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299818"/>
    <dbReference type="KEGG" id="aten:116299818"/>
    <dbReference type="InParanoid" id="A0A6P8I8K5"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564388.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="68021" checksum="7BAFE84DDF760443" modified="2020-12-02" version="1">MTWYCVRAALIPLLCLFFWGNRIYGRNIYKNDLQHVASSSRNLPLARNAFRSKLRLKSPLKSGSDLRAEILLQFFFSKTLCKFVKKQTGEFERQCEISSQYPPFKEIDFLSFIQNPLPPGVLKTTSPFGPESSPAFRLQPWANIGRFASYFFSSRIKPFFSITAIVRPTSQRSGYLLTIMQMPAHSRIAFGLKLHSNEQNTFITLEYTNITRQKHVFRFKVPQFTGSWRRLGVAFQSREVSLYLECRKVETKYLKEDSPDIFVPSPSGIYVGSAGFLASGKQPFLGDIAELKYYGRPEEAMSQDCKKEYFTTIKPTTIPSTTTSSTTTTGAPITQSTPRVVSTSKSTTISLDTTKSRNLPAVRKTSATQHYTQNNTDEQPTSPVTGISTDFTKPPPTTFPSASLSTESSLGTDHTPPATGISTDFTNVSPTSTSKTSDKPEGTSATTASPTVSTGRDSTGTTAASPSVSTEADSTGTTAAISSVSTGRDSTGTTVASPSASTETESTDTTSESAETTRRTLKTTAAQVMTTESAETAGRTTKTTAATEMATESAEATGRTMKTTAATEMATESAEATARTLKTTAAPEMTTESAETTXRTLKTTSAPEMTTESAETTERTMKTTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8N1</accession>
    <name>A0A6P8I8N1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase MARCHF6</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Membrane-associated RING finger protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Membrane-associated RING-CH protein VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116299113</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with DIO2. Interacts with SQLE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031563606.1">
        <property type="nucleotide sequence ID" value="XM_031707746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8N1"/>
    <dbReference type="FunCoup" id="A0A6P8I8N1">
        <property type="interactions" value="2525"/>
    </dbReference>
    <dbReference type="GeneID" id="116299113"/>
    <dbReference type="KEGG" id="aten:116299113"/>
    <dbReference type="InParanoid" id="A0A6P8I8N1"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000096">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="644"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="686"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="724"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="820"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="22">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031563606.1"/>
        </source>
    </evidence>
    <sequence length="919" mass="103874" checksum="708BA52A4C863FF2" modified="2020-12-02" version="1">MEDEEREVDICRVCRTEGTPDKQLYHPCICTGSIKFIHQECLLQWLKHSKKEYCELCNHRFTFKPIYSPDMPTHLPVQDFISGLAKSILRAVRYWLHYTLVAIAWLGVVPITAYRIYRCLFTGSVSSLLTLPLDMLSTENVFMDCVRGCFVVACTLCAFISLVWLREQIVLNGGPEWLQQNVDPLPHIPANLFGGGGGHGANGNGGADDEGNNNPNEGGGGGGGDGENDNEDHEDLHEEENGPNVAIDNAAINNVDDENNWNPVEWERGAEELTWERMLGLDGSLVFLEHVFWVVSLNTSFILVFAFCPFHIGQFAVILFSIEETVQSTKFEGILTTVLGYVILAMCLILCHTVSSLFSFKRAKRIFGLCYVVVKVSLLMVVEIGLFPLVCGWWLDICSLALFGATLKDRIQSMSAAPGTAMFLHWLVGMVYVFYFASFVLLLREVLRPGVLWFLRNLNDPDFHPVQEMIRLPVYRHARRFLLSLVVFGTTVLLMMFLPVSLLKWCIPSFLPYNVQLSSEAPVSELSLELLLLQVVLPALLEQGHTRQWLKSVIRGWAVTAAYLLDLRSYLLGDVPLDGQENIFGYGPAYNAAPVNNDHPNNNHNPPPEQQHQPPPPQPIAHNPDGTVFGFQPYIRPNTFSFKIVMLVLFMCLSMSFASFVTLTVPVAIGRAIMSLWMGNLPVHELYTAACGLYFIWLVCRLCVVTMSWIPLGIRGMVEKVGNWIFLGLKCVFIAAILIGLVPFLLGLLFELIVVIPLRVPYDQTPLYFPWQDWALGVLHMKIICAVTMMGPNWWLKRVLEQVYHDGIRNINTFLILRKLALPVVLTLLLALTVPYVLAAGIIPIFVKSEDTRLYCLRRIYPLLLAVISVILCLAFQGRQFQRLYERIKNDKYLVGQRLVNYDHRKPKQNKTTHKAKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9Y7</accession>
    <name>A0A6P8I9Y7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA ligase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564858.1">
        <property type="nucleotide sequence ID" value="XM_031708998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9Y7"/>
    <dbReference type="GeneID" id="116300190"/>
    <dbReference type="KEGG" id="aten:116300190"/>
    <dbReference type="InParanoid" id="A0A6P8I9Y7"/>
    <dbReference type="OrthoDB" id="5990465at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564858.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58684" checksum="9758A95064BC3F5D" modified="2020-12-02" version="1">MNIKDCYPMRKRRSLDKTPGRSTNNDAGRLNTPRRIQSNHALAEQGLDVIWDNNSPSPSRTLLLGKRKKHAGSDSSSSGGEISDLVKKLADKTGQTPTNNSLLNYWLEEEVSHSDAAGDKHDGEKVKSVSKKKKQLKTPCRRPRELRKSRRNKNKLSKELEMLASIMQSETENVSTHPSTSTNQSSSIVLKPIKTEDNTFRSYTNSSDKDKMDTKSTTTNAELKSPPLPSVDDCDDFDWEEDEEGDVILSQVDLSGLCDDDTVTKDKMFTNTQFFNEQERSNQTLNCKLEKDSENENLDLDETSFVTESWDFDDDFDFDDNLDNKDQLLQTLDEVERTQSIISNIPSMSQTNNCTLRTIDVKEQDHVLDVKIAKMKYSQSKSSYVKEGNTTKKNANLKVEPSESRPMYTKVRSTIKYEENKEVFEVKNSRMEPFKGKPSYTKEKSINNYNTENKSNVLGEKNVNVKVEPSQSKPLYSKEEIERKKLQAQQKLKQKQKLKALVPKLDVYRLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA08</accession>
    <name>A0A6P8IA08_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tripartite motif-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116297436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561520.1">
        <property type="nucleotide sequence ID" value="XM_031705660.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116297436"/>
    <dbReference type="InParanoid" id="A0A6P8IA08"/>
    <dbReference type="OrthoDB" id="27136at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
        <property type="entry name" value="RING-HC_PML_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="578"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="11">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031561520.1"/>
        </source>
    </evidence>
    <sequence length="661" mass="75192" checksum="B4B9962B527E23F8" modified="2020-12-02" version="1">MESFLEDLKKHVQCSLCNDTXTEPKILPCFHTFCKPCVGXHAELIDXVNVFKCPRCKSQIHLPEPXSVEDLQPSSLHSRILKGLALAKGEKVCSVSESHSPASWYCFECDHSLCQECKKNHSYFIKDHKVVCLADLKKEDIEFITTRENPCKSHPQHRLESFCEDCDDMICVTCWKXDHKDHKTMSLXXFASIKKDVLSKHLQVLEQLKLDEKEQQQQEKIAKTIKQQGEKARHEVKENTKKMIQILQENERELLRQIDEKFGTATTNLNIIPHIPAVEEYIRNMMEKGLASEMMKIQETQCSEKFIFNPIPLSSRIVFIPNQELXQQVNTGLGEIQTHSETDDDDVEIEGKVEVDSQLTAEVQVNENHVSNVKPQQMRVTQGFQIKDVSDTYNCLTGMIAVNRDNSRLAIGVTNTSYDPSRSYCKVHIFKTNGDLILSYDCKDSVQEHGLGPDSLAFLNDTDLVIADKDNRRICIVNTITGNLFKTFXNQGAIHNEFSYPYGVHVDDDXNIIVCDRDNHRVRVFTRDGDYKYQFGLTRKDXFDPVDVITHDGRFYVSDHYNHVIHVFEKKGKVLTRISTIGGYGSDDGQLSXPXGLAIDNDHHLLVCDXGNNRVQKFTLDGXFAGKTVTEDNIYNPVSIAALNDGQILVCMANYAVQFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA27</accession>
    <name>A0A6P8IA27_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116297462</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561545.1">
        <property type="nucleotide sequence ID" value="XM_031705685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IA27"/>
    <dbReference type="FunCoup" id="A0A6P8IA27">
        <property type="interactions" value="3278"/>
    </dbReference>
    <dbReference type="GeneID" id="116297462"/>
    <dbReference type="KEGG" id="aten:116297462"/>
    <dbReference type="InParanoid" id="A0A6P8IA27"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07623">
        <property type="entry name" value="BAR_SNX1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06859">
        <property type="entry name" value="PX_SNX1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000012">
        <property type="entry name" value="Sorting nexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000016">
        <property type="entry name" value="Sorting nexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="15">
        <location>
            <begin position="114"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031561545.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56286" checksum="7FDE942D2396A09A" modified="2020-12-02" version="1">MADSEAPALFDDEPSPQEETQEPSPNPFGDTTEISLDSDDKEESEPAKVDVEKTEEKQSEEETPDEKSKDEPQGAASVDVTNLSEPEEAPKKEDKPKPKPEEEEEDVEEETDTFDLEIKVMDPEKVGDGMNAYMVYSVITNTSMPEFKSPTTTVKRRFSDFLGLHERLSSKYLHLGRVVPPAPEKSVLGMGKVKFGKEEEKSKEFVDRRKALLERFMNRIAAHPSLRADPDFRQFLEAEMLPRAKDTAALSGGGIKRFVKSVGDTMFNLTTKMSESDQWFEEKQAQIETLDQQLKKLHHNVELLVMNRKELSTTTGSFAKSAAMLSNSEEHTSLSRALTQLAEVEEKIEQLQSQQAETDFFVLSELLKDYIGLIQSVKACFHERVRSYSNWQSAQQTLTKKREALVKIELAGKNEKLPQAQEEVKEWEQKVEKGQEDFEEISKTIRKEMSRFETNRVKDFRQAIITYLEAMMETQQQLIKHWEGFLPEAKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBC6</accession>
    <name>A0A6P8IBC6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116299983</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RBM8A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564581.1">
        <property type="nucleotide sequence ID" value="XM_031708721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBC6"/>
    <dbReference type="FunCoup" id="A0A6P8IBC6">
        <property type="interactions" value="3289"/>
    </dbReference>
    <dbReference type="GeneID" id="116299983"/>
    <dbReference type="KEGG" id="aten:116299983"/>
    <dbReference type="InParanoid" id="A0A6P8IBC6"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000525">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031564581.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18589" checksum="71C0B3F6A59F7061" modified="2020-12-02" version="1">MADVLDVDVDKPEFFDDEGEDDVQRVKQGAKKRKGRGFAGDSASKNEDTYDSLEAGQSGETGPARSVEGWILFVTNIHEEAQEDDVHELFSDHGEIKNLHVNLDRRTGFLKGYALVEYETFKEAQSALEALNGTELLEQTITVDWAFVRGPNKKSRGGRRRRDSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBG9</accession>
    <name>A0A6P8IBG9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Scavenger receptor cysteine-rich domain superfamily protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564641.1">
        <property type="nucleotide sequence ID" value="XM_031708781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBG9"/>
    <dbReference type="GeneID" id="116300023"/>
    <dbReference type="KEGG" id="aten:116300023"/>
    <dbReference type="InParanoid" id="A0A6P8IBG9"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027610941" evidence="10">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="110"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="150"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031564641.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="23815" checksum="D2D76183854697A9" modified="2020-12-02" version="1">MAKTGFIFLLLLVASFFELATATNTCTWGFYMCASNSQCISSRNRCNGYTECSNGEDERNCPASCSGFYGHFRCNNNNCISRSNLCDGVNNCGDGSDESTALCGGAAFHVRLVGGRSSNEGRLEVYYPPTRTWGTVCDDDWGLSDAIVVCRQLGLPRATQAISGAEFGQGTGPILLDHVHCTGSELTLSRCSSGGWKNHNCGHSEDAGVVCGAAQPRLTCLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBH0</accession>
    <name>A0A6P8IBH0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Bifunctional glutamate/proline--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.15</ecNumber>
            <ecNumber evidence="5">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Bifunctional aminoacyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC116297965</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:23541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:14306"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="4"/>
    <dbReference type="EC" id="6.1.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031562145.1">
        <property type="nucleotide sequence ID" value="XM_031706285.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IBH0">
        <property type="interactions" value="1426"/>
    </dbReference>
    <dbReference type="GeneID" id="116297965"/>
    <dbReference type="KEGG" id="aten:116297965"/>
    <dbReference type="InParanoid" id="A0A6P8IBH0"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00936">
        <property type="entry name" value="WEPRS_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000006">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00762">
        <property type="entry name" value="WHEP_TRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="25">
        <location>
            <begin position="790"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="WHEP-TRS" evidence="25">
        <location>
            <begin position="868"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="24">
        <location>
            <begin position="1009"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="725"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="807"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="917"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00061295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_031562145.1"/>
        </source>
    </evidence>
    <sequence length="1470" mass="165991" checksum="005BFE809A5E43F4" modified="2020-12-02" version="1">MWTRIAVKLPARSGKLSFTAFIQARILCTTTLSSSMKTYTVVASTSNPPIATLLTAEHLKSTGVVKVELGDSTYIKLNDILTLTGDHNVSRHLARLVPAKGLYGQNMIQASEVDHWLEFCNRCQSNPEKALQQLNKNLAPVAYLVGPSITLADFAVWGMIRGNGRLSNLLNGDKNFEHVSRWYKFCGSQNPFSVVSKELPSNYEGKDAAASKSGGNMGTKMKQEGKYVDLPGAEEGKVVTRFPPEASGYLHIGHAKAALLNQYYKNVYNGKLIMRFDDTNPAKENAEFEQVILKDLEMLHFKFDMFSHTSDHFDTIIQYAEQMIQKGQAYVDDTPTEKMREEREQRIKSANRDNSVEKNMQDWEEMKNGTERGQMCCLRAKIDYNSLNGALRDPTIFRCKPEYHVKTGYKYKVYPIYDFACPIVDSLEGVTHALRTMEYHDRDPQYYWFLDTLGLRRVHIYEFSRLNLQNTVMSKRKLTYLVNEGYVDGWDDPRFPTVRGVLRRGMTVEGLREFIILQGSSRATVQMEWDKIWSINKKVIDPIAPRYTALQKDSVVPYNLSAAKEEFKMCPLHPKNPDVGTKKVWYSPKVFIEGEDAQTLSVGDMVTLMNWGNTKVTKINKNSKGMVESIDGELHLDNKDFKKTTKLTWLADPSSASNIPVVMVHFDNVITKPIITKTDNFKDYINKNTKTETLMFGEPELANLKKGDIIQLQRRGYFICDQPYEPPSRHTGRESPCVLFSIPDGHTKPQTTGGAKPSKEENNKKEKGNKKEQKKQNNAVQVKPSASPEAVEKLKAEISKQGDLVRELKTSGAEKEKVTAAVADDKEMTGEDLAASGKGKQEKKQDQKKNGSQKPEEKPVAAVALSKEAEELKDAITKQGDKVRGMKTSGAPKDQVDAEVKTLLSLKAQYKELTGEDVAGAGGKGKKDKKDKKKEAKSEEKKSKEDKPQQASKGDGGGDEGGLKKTTRLGMEAKKSENLSEWYTQIITKSEMIEYYDVSGCYILRAWSYAIWESIKAFFDAEIKKLGVENVYFPIFVSQAALEKEKDHIADFAPEVAWVTRSGQSELAEPIAVRPTSETVMYPAYAKWVQSHRDLPLKYNQWNNVVRWEFKHPQPFIRTREFLWQEGHTAHADRESAIEEVHTILEHYANIYTELLAIPIVRGRKTEKEKFAGSDFTTTIEAYISASGRGIQGATSHHLGQNFSKMFDISFEDPDPECQEKRYVYQNSWGITTRTIGVMTMVHGDDQGLVLPPRVATIQVVIVPCGVTINLPAKDKEELLNKCAEYESALKQASVRVKGDFRENYSPGWKFNHWELKGVPIRMEVGPRDVKNNQVVLVRRHDKGKEIVQSANLIDHVKETLEKIHHGMYQKAKKDLDDHMAVTTSWDEFLSMLENKKIIQAPFCGDSTCEDKIKKDSTREESLEAGAPSMGAKALCIPFSQPAQLTPETKCVHPDCVRPAKCYTLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDJ8</accession>
    <name>A0A6P8IDJ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116299063</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116299063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563560.1">
        <property type="nucleotide sequence ID" value="XM_031707700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299063"/>
    <dbReference type="KEGG" id="aten:116299063"/>
    <dbReference type="InParanoid" id="A0A6P8IDJ8"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="253"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563560.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="59498" checksum="7FC6726F95E7B25F" modified="2020-12-02" version="1">MLTNSPSRIEAFAGETVRFNWNYTVGDKNMDFGYYVTSPVWYYYNTDGTKSVIAVDDGXHGWKWTLSRRTCPTRLLYPTVRISKESVATLVISNVTKNDNGWYGISLVLRISPSVTNKVELIVTDKMARFTKXPSSTLFVARGKAARFEWNYTYDNRNMEFYPESPMWAYVDQNNQWITIATVKKDPSSSAVINTTTCPARLLNPTRVRIEQPATLIISNVTEADNGIYGCKLRLRRELSINSTSTLVVTDHPKVLLSTLATKIIQEGSSLNISCSANASPVPYVTWMKIAPKKRLVISKTVGWSFLXFMEIKRNQGGTYECQATNNPNEPPVTSKINILVIYFEHSSIRLDKNGEAQIVEGEDLNITCAISPIWLDNVMWVHVPTHESLKLESVKIIVLVAYIAPGKRFPQTKRPNKKSNDSTDATGQIIFGNINSEPPTAVQSESMTNTDETVHGHYAELTSNSVKMSSLQNYEHLDPTCREQHRTKXFQTFGTHQQSKYEQLHLGTSLSAYQRLRLKYEDIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDR4</accession>
    <name>A0A6P8IDR4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031563715.1">
        <property type="nucleotide sequence ID" value="XM_031707855.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IDR4">
        <property type="interactions" value="3030"/>
    </dbReference>
    <dbReference type="GeneID" id="116299226"/>
    <dbReference type="KEGG" id="aten:116299226"/>
    <dbReference type="InParanoid" id="A0A6P8IDR4"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000060">
        <property type="entry name" value="Serine/threonine-protein kinase mTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000094">
        <property type="entry name" value="Serine/threonine-protein kinase mTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="3">
        <location>
            <begin position="1345"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563715.1"/>
        </source>
    </evidence>
    <sequence length="1891" mass="213352" checksum="100A8C41E5E0203D" modified="2020-12-02" version="1">MMQSLLAGLKSRSDEVRLQAAKGLQHYVSTELREASPEKHTSFMDDFNHHIFEMVSSSDANEKKGGIMAIVGLIGIAGGGNATKMTRFANYLRNLLPSNDTMVMEMASKAMGRLALTGGTFTADYVEFEVKRALEWLGGDRNEGRRHAAVLVLRELALNAPTFFFQQVQPFFDNIFNAVRDPKQAIREGAMEALRACLVILAQRETKEIRKPPLWYSQSYEEAKRGFEDTVNTKEKGVVLTKEDKAHGSLLIINELMRSASPEGEQFKKNLEDIYCDQTQSQISLNDLGITSPKSKFAQQTGFLHQRSTMSTIVSSGLGEINPMCHSKVCKEYMEDKFDEVCSLILKYRGVRNSAIQQTLLTLIPRLAAFQPQRFVKTYLHKDVISYLIAALKRERERSSAFKAVGLVAIAVKQNIEKHCKNILDLVKASLPIKDLGHKRQKTVTVDPMVFACVAYMSRAIGPKISKDIKDLLEPMLSVGLSPALTACLHDLANQVPQLKRSIQDGLLKMLSQILMHKSLRHPGAPKSSTPTLTPSASSHSLFDTAENQSTVLALRTLGSFDFDDSLRTHAHLVRQCADTFLGSEHKDIRMEAVRTCSRLLSPTTHPMVSANQTLQHGPISATSTHVVSEVLNKMLMVGITDPDPDIRYCVLISLDERFDAHLAQAESLAALFVALNDEEFEIREVAIIIIGRLSSLNPAYIMPSLRKTLIQILTELEYSGVARNKEQSARMLGHLVSNAPMLIRPYMEPILKALIPKLRDPDPEVVISVTAAIGEHAQVCGAETGKRMNELCPILIDMLQDASSYPKREIALWTLGQLIGSTGYVVEPYRKYPNLLEVLLNFLKTEQAPRIRREAIRVLGLLGALDPYKHKLNQSLGAQDDSGNTTTGKDSEIDTSTSEMLVTMGSVQLDEFYPAVVIAALMRIVRDPSLSGHHTMVIQAVTFIFKTLGMKCVSYLSQIMPSYLNVIRTCDFGFREFVFQQLGNLISIVKQHIRNYLDDIFALIKEYWTINSQMQTTIVLLVEQIAIALGGEFKNYLPQIIPQILKVFMHDNSVQRSVTTKLLNALQMFGSSLDDYLHLLVPPVVRLFDSHDIPLNVRKCALDTLDRLSESLDLTDFASRIIHPIVRTLDNCPELRTTAMDTLSSLVFQLGKRYSTFIPTVNKVLMKHKIQHQRYDVLICKIVKSPFVLDWENDPLLHRQKAGKGNFADDSATTAAIEAASIKKLAFKPDSLSKAWDAARCVSKDDWMEWLRRLSVELLKESPSPALRSCWATAQTYPPLARDLFNAAFVSCWSELPEELQNELVRNLELALKSQIPEITQTLLNLAEFLEHTDKGALPLNSDLLGEQASKCRAYAKALHYKEDEFHKMPTTETLEALISINNKLQQPEAAHGVLVYATNKHGADVEIRERWYEKLHDWENALAAYKSKLEQDPDDMALILGKMRCMEALGEWGELHQVACDKWPNVSDEIRKNMARMAAAAAWGLGNWESMEEYTCMIPRETQEGAFYRAALTLHHDHFQQAQGCIDAARDILDTELTARAGESYNRAYGAMVTVQMLSELEEIIQYKLIPERRESIKRTWWNRLQGCQRVVEDWQKILQVRSLVLTPQEDMQSWLKYSSLCRKSGRLALSHKTLVMLLGSDPSKHPDQPLPTTYPQVTFAYMKHMWREGQKEDAFQHLQRFVHTTLHQQALQSLSPTDDDNKREELLKLVARCYLKLGDWMSSLQGFNDNTMPQILQYYSAATDNDRNCYKAWHSWAFMNFEAVLYYKNQQGLEKNGVNTASPLTPPPSPKTVNPVISYAVPAVRGFFKSIALSSGNSLQDTLRLLTLWFDYGHQSEVYESLVEGIKTIQIDTWLQVIPQLIARIDTPRQLVGRLIHQLLTDIGKHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE48</accession>
    <name>A0A6P8IE48_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Centrosomal protein of 112 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031564025.1">
        <property type="nucleotide sequence ID" value="XM_031708165.1"/>
    </dbReference>
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        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="GeneID" id="116299504"/>
    <dbReference type="KEGG" id="aten:116299504"/>
    <dbReference type="InParanoid" id="A0A6P8IE48"/>
    <dbReference type="OrthoDB" id="78101at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055310">
        <property type="entry name" value="CEP112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027831">
        <property type="entry name" value="DUF4485"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18871">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 112 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18871:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 112 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4485"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4485" evidence="3">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="527"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="672"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564025.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="108657" checksum="DD75A759A65D590B" modified="2020-12-02" version="1">MAGHRYSERSPPESVSLIEKQDAKLDRFLEEMKPYVLRLPHKLERQRVGLWIKKLCEPPGSAPSSRKNRNLYAQLLLHMLKRGLLEDPFTRRPDAGPLQPLPSYMSIYLDEPISKRILSHGSDEEYGRDTPDWVRDLGSSSASSIMSDMSGANQPRIRRELPTTNGAHPMPSARSTTTHSSSSRGGDRPNYAADYEPDIINGYHGYEPRRSLDYPKDDEYYVNGDERGHYGVREDPVHAREYRHSDSGRPSSSSPSKSTQNNGYSHYPRGMQLILSQVNREASTIKEQKDKQIAELKSLXEQSGESALNDYEKKLNDKIAEFEAEKFEMQKQHTNNIQELLDETNQRLQKMEAEYNKQSENTALVVQELEARVHQLTEESEALQNSRMQLGRNKEELADKVVTLTNELKDAKSMISKYERDHSRMMTDHQSTIQQIQRKTDSSIELLKKEHAAATARSADAISDLESQLAQTKQALQDAEYQRQKQVREMESTGQQDKMSLEHLYDKKFRSLQAEMDQQDIEHQKRVRKLEDQVKERDEKISQMTEAQKQQAHQAERALEDFKNQVEKNSARMFDEMKTQMEKVEEDLAHSKSLREKQSREYSRQIDDIKMKHDKQIAELKISHEQDKAQMLRSHQAERDCILREQEQERDLQSEKLHQKMMDMENQSRDRSTKDAKVNAELEQQVRELREEIMQANSLHKTQLMELNLLREEEKQAFKRQEENLQAKGRSELEQQKLELRRAHSAEMEQLLEKTNERLRMMEQEFTSRSEKAQEANRTLDEEIKKLREDNLRXRLNSEKKLSELTNKFNEEKAALKKHRDSIVGSLEQDSQAQKSMVRHLEKRCQQMELESQEKISRLRLKYEEKMKGLMPESVREELEDTIESLRQQVSVLQSRAQVLQEELDTRNKFSMSSFNVSSYKDEXDRQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFJ3</accession>
    <name>A0A6P8IFJ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300683</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565453.1">
        <property type="nucleotide sequence ID" value="XM_031709593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFJ3"/>
    <dbReference type="KEGG" id="aten:116300683"/>
    <dbReference type="InParanoid" id="A0A6P8IFJ3"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vitellinogen open beta-sheet" evidence="1">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565453.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11889" checksum="882649F2F94675F7" modified="2020-12-02" version="1">MAVAGNTDTSFTKSMLFLDVEAAIPTILGLPLKLEAKGTAVVSAVENKDPVLFFGPVTFNYLGNRKISAVVEIASRFGVDSIFAENQFIISRNTLYTPSQSGTMQVLNTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFL4</accession>
    <name>A0A6P8IFL4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase subunit gamma-2, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565473.1">
        <property type="nucleotide sequence ID" value="XM_031709613.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFL4">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="GeneID" id="116300697"/>
    <dbReference type="KEGG" id="aten:116300697"/>
    <dbReference type="InParanoid" id="A0A6P8IFL4"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF8">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon-binding" evidence="1">
        <location>
            <begin position="344"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565473.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="51335" checksum="6B5E8AB2DA9BD64C" modified="2020-12-02" version="1">MSKLNIHLNKLLALASRHKFIIERTVESTKGSYSVYEYGPLGSELRRXLRQLWWRDVVIYKERVNGVEFSMFEPENRSIFTEFERKWVTNKATKLLHDDNHKPATKRYVQMANVDKLVNEVVSYILENNCNDMTKTRDDLKELILRNTIQVKTRNNMHSEGLDMWNKTSSAVSLPQGFAWNGKYVAMDSNTNFLRNIEDETLCLQYFFQARTAKYWLNYWKRERLVWWRKFANVPSNFSVFDVQQSKSQANHVTEVQYAFPWGKEEIETIEYWPNSNPFGSHLRIVSEDISELHPHILQASASLNKGFVALLVDAIEEKERXNSNGDVSTKSVLYLHPSLAPVKVAILSQNKEKNELSEVSLQLASEFRRAGISTTSSEWDDRPPEEMYAYNDEIGTPYCITILESTLSNGVVTLRNRDTTLQEFIHISDVLKTLQNHLKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFT8</accession>
    <name>A0A6P8IFT8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Tetratricopeptide repeat protein 28-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116300768</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565552.1">
        <property type="nucleotide sequence ID" value="XM_031709692.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565553.1">
        <property type="nucleotide sequence ID" value="XM_031709693.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300768"/>
    <dbReference type="KEGG" id="aten:116300768"/>
    <dbReference type="OrthoDB" id="5970324at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="4">
        <location>
            <begin position="231"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="786"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031565552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565553.1"/>
        </source>
    </evidence>
    <sequence length="1321" mass="150635" checksum="EB4A06A1863D4AE7" modified="2020-12-02" version="1">MNEQRNKKKKKKKKIKDTSSNSEVQYNSPNNSDKVFQPIILARFCTSFGEYLDHDLTREQLIFLYKECTEIAFYNNDIHLKILLIEFSFSKKFPFDSRLKEFYGYFSKNGNGLENRILYHKKCIDVANATRNKKEEMGAYFSLGLLNEQLNQYYDVIIYNKKCLAIAREIGNKRVAMSSCLLLARTCRELKLESEAIAYCKSCISIAKEIDKKAVEMTACFIVGKLFFSQSNYKEALAYSKRSLENTKAIGDKRYESMVYLLIQDCQYHMNEYKDAVVTGQKAIAAAKDIGDKLGEKVAYALLGKTYELLNQHEDAVDCTTKSLELEIESGDKISAMTEYYSLGKIYHSLGHHDSAIACAMKYIDIAEETGENRSKSHAYLLLGDIYNSLNKFDEAVMYLKKCLSNSETVPVEEKLDFQAHFLLGKVHVSKNQFDTAIIHLTKALEFARYNTKEEIAYVYMALGDSYLQLQQHDKAREYLRKCLDIANRSGNRRAEGDAYMLLGKTYDSLRKESDAILHFKKGIEILRENGLVQHEMQGHLLLGKMYRSSKNYNEAIESLKKAIVIALRTGDKNMQKDVYYEIGNIYEFMNQYDRAIRYGKKYMEVAKEIGNEDDVMEAYLALGVAYLGLDNYEDTFFNLKEGLKIATERENTSKAETFNSFLNNLHLRVEAIGQATNFAGFISCGHLCLEFLKESSDGQDEKCNEFREKLICHRLNGEYEQAKVCLKRQLDLFERCGHYHGTDKVYCLLEIADIHDTLGQYENSLQCYQESLAIASHVGAKHLQAISYSRQGRTYLKLKMMKEAENSFREAIRYFETMFDALGGEDFKLSLLDAYVMCYKFLANVFFHTKQIKDALVVSDRGRARLLNGLLQKCGMNGEINDVLEYKDIESLLSQYKCSTLFYIDIYPMVYIFIIENDRELQFSMKRFGCTCQCADTVTFEMLIDKALNEIEIWDHVVDNCENRSLDKPPYEVAVRHSEEIISLTEEFEKSHFSGKKRSPDDEKPQKSEENIEGSALEWLHNSLLSYDAIHSFKQDGRHAITKHIKYFGQEEEILIIPDGPLYKVPFAALRDPDTGRYLSEDKRIRLIPSLATLKALQGRTEDYYSKNGAVIVGNPLVGKVMFDGEETEFDPLDNAFAEVIAVGNVCKATPLTGEKATKQAVIQRLNEGVAVVHIAAHGSLSKGTIALAPSPEVRATKIPDEEDYMLTMAEVQQAQVRAQLVVLSCCHSGRGEIRAEGVVXMCRAFLASGARAVVASLWAIDDDATFEFMFKFYTRLMDGKSASASLHQAMNEIRXSSGYSAPKYWAPFFLMGEDVTIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG18</accession>
    <name>A0A6P8IG18_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031565679.1">
        <property type="nucleotide sequence ID" value="XM_031709819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG18"/>
    <dbReference type="FunCoup" id="A0A6P8IG18">
        <property type="interactions" value="1611"/>
    </dbReference>
    <dbReference type="GeneID" id="116300858"/>
    <dbReference type="KEGG" id="aten:116300858"/>
    <dbReference type="InParanoid" id="A0A6P8IG18"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565679.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38194" checksum="72FA4BE263144BD6" modified="2020-12-02" version="1">MGGQVSRTDFEWSYTEEPHASRRKEILAKYPEIKKLMGFDPNFKYQVAFLVVLQFLLAYIAKDLSWPLLILVAYIAGAVINHALLLAIHEISHNLAFGHSKPMYNRLLGFFANLPIGIPVSISFKKYHLEHHRYQGDEELDVDLPTEFEARMFFNTITKLLWVIMQPFFYSLRPMFVNPKPPTSLEAINFVLQVVTDAVVLYYLGGKSLVYLIASSLLGMGLHPVAGHFIAEHYMFTEGYETFSYYGPLNFVTFNVGYHNEHHDFPSVPGSRLPMVKKIASEYYDKLPHYHSWSKVIYEFITDPKVGPFARVKRKSRNQLVKQTLDDSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHM1</accession>
    <name>A0A6P8IHM1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide FF receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566322.1">
        <property type="nucleotide sequence ID" value="XM_031710462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHM1"/>
    <dbReference type="FunCoup" id="A0A6P8IHM1">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="GeneID" id="116301411"/>
    <dbReference type="KEGG" id="aten:116301411"/>
    <dbReference type="InParanoid" id="A0A6P8IHM1"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="42"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566322.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="60880" checksum="A7E1EEBAC0BCAC49" modified="2020-12-02" version="1">MNSTSNLSSIVASDHIPPDASLGFVIFKIMIYVVIVVMTMVGNVLVITVIRYDKKMRGSSHILILNLAVCDLITPTISIPFDLAYEELNYAWPFGGVMCKMLWPGQTFTTTSSALILTAICIDRYRALVYPFKVRWAGKFCLMVFSMYTLALVMVVPYMLVLHLDEGGKNVDCSEKWPSPQKAFRKAYTIVLFLSQYALPLVIMITLYSITLRSLFNNSKQFLSESNIMKTGSQIRHKSRDDSQRELSLQEIRKEQHLKVTKMFITVVIVFAVSMFPNQVLWLWVDFGNLVNNEYFPIIAIICRIFTYSNSVLNPFIYGLYSKDFRSGYKKAGRKISKVNKKHQAWYHRFNGTGRSQFQSSCISRAGMDEGKTFINRNKKTSSGSNQGSSMNQSKEMSPLEGGSNYSKKEKSIFDEQNHLLNKKGFSVGDETSSARVETRPQVSADPKDFTQTTQCEETLTALENKVEQAVEEESGEQGKKGCSLCDTEEKSDSDLITNIYKRIKSQNANNENRTNNRESLNTDLADYLNELAETQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHU1</accession>
    <name>A0A6P8IHU1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxylysine kinase</fullName>
            <ecNumber evidence="8">2.7.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116301468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19049"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57882"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58357"/>
            <dbReference type="EC" id="2.7.1.81"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.81" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031566391.1">
        <property type="nucleotide sequence ID" value="XM_031710531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHU1"/>
    <dbReference type="GeneID" id="116301468"/>
    <dbReference type="KEGG" id="aten:116301468"/>
    <dbReference type="InParanoid" id="A0A6P8IHU1"/>
    <dbReference type="OrthoDB" id="9973935at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047992">
        <property type="term" value="F:hydroxylysine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566391.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42011" checksum="B13C8FCFF0661993" modified="2020-12-02" version="1">MSLVRPEVSNDLAMSLAKSLFGFSHISKLKELESFSDRNFYIKGTRIHNDQPGEFVLKVLNSLDSQEKEQLDAEIKASEFLRERGFPCPEIFSVVGADDKMPHVKLADGSPREISKTAGCVVRLIAFLPGDVVDSLERNPELMFTIGKLVGALSLQFKDFSHPGLKSRSEQNFRWDVLEIMNLEKYMVSLTDEYQIHLFREVQESFVSKVKPKLGEFRRGAVHNDLSGENLLVSKPPYTVTGVVDFGDTMESVLISELSNAMAFFMKGDRGIEFSGYILAGYQSVFPLSRHELELLYYFVAARLTQIALHSQCNVIKQPDDKSMQACLNKYFSTIRSFWSRSKEDVEKIWHVCEEKLRNSIKNNQPLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHY7</accession>
    <name>A0A6P8IHY7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566329.1">
        <property type="nucleotide sequence ID" value="XM_031710469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHY7"/>
    <dbReference type="GeneID" id="116301418"/>
    <dbReference type="KEGG" id="aten:116301418"/>
    <dbReference type="InParanoid" id="A0A6P8IHY7"/>
    <dbReference type="OrthoDB" id="10385235at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566329.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20442" checksum="6ED040A583BC18A0" modified="2020-12-02" version="1">MQPEKYRYNTDNVFLRAAMTGERVQAEGKLAEGRVRKRINSKLLKIVSSVDSAQPTSILEEFTSEKSSDEAEESVKSNQTAEERDRQTRYLPLANCNSPTEVMSSLRNKHLAERDDGLYHDDASKKGFWRAFSKKKRKKTRVQEATDSLPDVLKAVKEAAEAHSEVLKKWQSTFDDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II67</accession>
    <name>A0A6P8II67_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301619</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566566.1">
        <property type="nucleotide sequence ID" value="XM_031710706.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116301619"/>
    <dbReference type="InParanoid" id="A0A6P8II67"/>
    <dbReference type="OrthoDB" id="10068389at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566566.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="52008" checksum="7A1C6E7B7B9AFB4F" modified="2020-12-02" version="1">MAXNETKLDCSCSNDLVRIDGYSLERNDRNTNGGGVALYIRNXLXYIVRNDLVIVPNMEIIVIEIHKPKSKPFLVSTWYRPPGSSIDLLKDFEMFLKAVDFEDKESILLGDINCNLAAHPKDSLASQMKFIYDTYQYSQLINDYTRVTNTSKTMIDHLITNKPEAISASGVLPVTLSDHYLIYGIRKLTSLKSEPRFVITRFMKNYRPDLIVEDLKDVHWTLIDNXNGPNEMVHFWENSFLDIINKHLPIRKRRIKNRPCPWLTHDIRGLMHRRDYLKKQYIKLKTDAIWSSYKIARNEVNVAIRKAKKRYVTNEISNNEGDSRRTWKALNLLLGRKSKITGISELKIDQSIYTDPDTISEAFDNHFSTIASKIADDIKPAQVSPTSYVTKATSRFVLVNVEPSYIVKLLSKLAVSKATGLDNISARLLKDTAQIIAYPLCAIFNXCLETEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKW3</accession>
    <name>A0A6P8IKW3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phospholipase A2</fullName>
            <ecNumber evidence="2 7">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC116302301</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal C2 domain associates with lipid membranes upon calcium binding.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="2 7"/>
    <dbReference type="RefSeq" id="XP_031567432.1">
        <property type="nucleotide sequence ID" value="XM_031711572.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567433.1">
        <property type="nucleotide sequence ID" value="XM_031711573.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567434.1">
        <property type="nucleotide sequence ID" value="XM_031711574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKW3"/>
    <dbReference type="GeneID" id="116302301"/>
    <dbReference type="KEGG" id="aten:116302301"/>
    <dbReference type="OrthoDB" id="5966938at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="132"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031567433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031567434.1"/>
        </source>
    </evidence>
    <sequence length="730" mass="83309" checksum="BFFE65ABC34B5016" modified="2020-12-02" version="1">MSAFQASYRPCLEFQITVLRGRDISKGKVADYIDTPDPYVRIRIPTAPSGKAATKVVCNNKNPEWHETFKFLLDPNKENTMEITLMESDIVSDDVLDTHTFRINDLEVDTTCKQTFKFGETSKVDVEMKLTRCPFSDELRFSGELCSEEKQFLAKRRQIVFEAMQEILGEQGPSNINEVPTVAILGSGGGFRAMTSLSGVMCALKDTRILDCATYIAGLSGSAWYISCLYSHPDWPSVHPRVVLEELRENVKENLIWLLLQPKWVYKHMQLISKKKKNGQPVSFTDIFGYLVGDTIRKGREPPKLSHQKEKVEDGFVPLPLYTCVNVKKDVSAHAFCEWLEFSPYEAGFPKYGTFMSTELFGSKFYCGRVLKKFEEPDLRYLQGIWGSAFTILLQQVVREGLKEPEEVIMAAENKGNLRKQMEDMVASDAIGHANKANGEESDEESNDEPKESPNKAEKDKEDAPEQNGEEHKSDADKFADIVDKVINKFEIFRTRQGRAGLVHNFLRGIDLKLSDDRTDNPDKLELVTEDKRIFLVDSGMVLNSPYPILLRPERSVDLYLSFDFSARDKDDEEPFKELLLAEEWAKKNNYPFPPINAAEQIEKEGLKECYIFRHPTDKSCPIVIHFALINKAFMEYSKPGVPRTEEEKLAAKFSIFEDPKKHYSTFNFHYPNDAFDRLSQLTEFNTLICEQTIKDVMAECVQRKKPAAVAKNVTPAKPKKEKKDKCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL50</accession>
    <name>A0A6P8IL50_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 436-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116302087</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567153.1">
        <property type="nucleotide sequence ID" value="XM_031711293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302087"/>
    <dbReference type="KEGG" id="aten:116302087"/>
    <dbReference type="InParanoid" id="A0A6P8IL50"/>
    <dbReference type="OrthoDB" id="6225450at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000226">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000185">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000771">
        <property type="entry name" value="zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000562">
        <property type="entry name" value="Zinc finger protein 786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="195"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="533"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="599"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="633"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031567153.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="78848" checksum="0821D34F9046479F" modified="2020-12-02" version="1">MELDPEWYAYQCTSGEVLFYYHAVTGEHRWAIHFCSCLKSKIAHSTTQPCCIWEPVKSQTCENGKFVRSIGTETEDQYFTTNHRNEEINESPRAEITFEYSISKDRLNGDGDNGTTLESSCADSTEKPVEVFLEDPFVSSGDKQNSSKRITLKLKEISRQEFSLADNIAPRKVPRRVDDITFPKKSLAIAKGDFATGSAESGNSSGKHLSVGQRKLEQSLDKKQSFTPGVLSSSKARNGESLSESLAAKRQRSSASSRKNPEPRKLLKRSNSNDQSTEETNDDDMQECYDEELTETRVFGDTAEHSLGEDPIVLVREPSSSLSSELGNQEGEFKDDADDQPSICQLCGKECATPAMLTNHLMKHQPNGTSCPICNKYFSRRQGLRYHVQTHAGDKPHICKICNKTFTKSASLVAHHRTHSGIRPFKCPKCNKGFTHSSNLSSHLRIHSSLRPYRCNFCSKGFKTSSHLTLHIRSHSDERPYECGECGKAFKNSSHLRSHEKLHLLPKTVFCNSCGEGFRSFSHLIYHQQTNPQCAEDDDQEDYEVGQNTQRNSRNESKVKQSHMGEPRGYQYNSNEMRRDSEVQRQRVKYDAISNMAEQYSFQRDRQELQQSTSSALTNMAEHSTQGERPEVHQNTSDSLSNTVQHSSQGNIQEMQQGXTSSLHEMQYEEQNPQQDNGTEDVSEKPALFGIKQLQSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN14</accession>
    <name>A0A6P8IN14_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double-stranded RNA-specific editase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568239.1">
        <property type="nucleotide sequence ID" value="XM_031712379.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IN14">
        <property type="interactions" value="2778"/>
    </dbReference>
    <dbReference type="GeneID" id="116302950"/>
    <dbReference type="KEGG" id="aten:116302950"/>
    <dbReference type="InParanoid" id="A0A6P8IN14"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19865">
        <property type="entry name" value="DSRM_STRBP_RED-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000009">
        <property type="entry name" value="Adenosine deaminase RNA-specific B2 (inactive)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="103"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="4">
        <location>
            <begin position="371"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031568239.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="76563" checksum="0465505909A68251" modified="2020-12-02" version="1">MAADGVSVSLDLNQRNDQEMAKSNGDAGDFGTKEGKLGGLSIEAMIAEERRGLKRRIDGEDDEMKDVEAGTGNDDSLLGSLMSALEKGQRRRKKRKQAFTTQQPKNALMQLNEFKPGLEFVLVSQEGPPHATTFAMTVSVDGQTFEGKGPSKQKAKHDAAEKALRSFIQLPFPIEMNSAQKSEPADFTKDTTCGTDADSTPFIAYPDQEKTATNVAIDKEAIDSSKNPVMLLNELHKGQLDYQFEEDPSQRNPFICKVGVSGKEFTGSGTSKKKAKLVAASKALSDIYGISGRQSGALPSVDQSVETMATAPPPQSQLPQHIADHIAQLTLDKFTELTWLLGDQGFRRKVLAGIVMTTMKDNEEXEYQVISLGTGTKFIGGEYISEKGYAVNDCHGEIIARRGLRRFLYSQLEAYARGEADSSILEKKPSGLFGIKSGTDFHLYISTSPCGDARVFSPHEGAPDEIDNHSGRKKRGLLRVKIENGEGTIPVANSATSIQTWDGVLGTEKLRTMSCSDKISKWNILGLQGALLSNFMEPVYLSSITLGSLYRYDHMSRAMFLRLGCVDCLPKSYRQHQPKMSGVSFPEARLPGKAPKNSLNWTIGDQGLENINTLTGKLSEALQXSRLCKQAMYARFCALWSKINPTXKPPVTYYDAKVAAQEYQAAKNSMVKAFEVNGLGIWLKKPVEQDWFDIIGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP14</accession>
    <name>A0A6P8IP14_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116302859 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568108.1">
        <property type="nucleotide sequence ID" value="XM_031712248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302859"/>
    <dbReference type="KEGG" id="aten:116302859"/>
    <dbReference type="InParanoid" id="A0A6P8IP14"/>
    <dbReference type="OrthoDB" id="298098at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="2492"/>
            <end position="2844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="737"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="950"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1326"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1544"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1613"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1690"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1957"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2256"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1334"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1622"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1690"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1958"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1989"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2260"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="2813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031568108.1"/>
        </source>
    </evidence>
    <sequence length="2844" mass="313800" checksum="5D159E6B84706225" modified="2020-12-02" version="1">MADDEETLTSINSTQPRIVYIRLGKDKTKDDIQDEIFKVVRKALKGTEASENGGQQDRNVVELPDFDARGIQDVAIGRDYVGLLFKDGRVCRFKCLCRNIKPSTKRKASPSSEEQTFQVQSDEAYARRLQDQLNARNLSTSACGSSAASSVSEETMFGLTEPPFRFGMPLNESNLLESANIPAEISSSSAEPLANVPESDFEKVTSLISEISXSSEKSGTQNVVENSENKSLSSTQLSSTSEIASASTSSRKQNNEASNQTSSCTEKSSSNVKNLFKSSSDSTSIGSTKEDESIRSRSLSDLNSASSARTSTLNVGQSSSLTNINTTRETVQSTLSFMSRRPPPSPTVVHRTILTADPILLRTSRPVFIPSHVLIPSFSQASTSVYTFDPRRLSSTFASRPPIRVFQRSGRRQIASPHEYRRSRDSNVLRRDRGNGSATEQSVEESASDFHYPDIEEIEWLQTENGEPVKFSHIGALHSEFILVEEHNGLLYHWPYTVENQDTMETDTLESELPDVGIPKAKVSPLIQELKLEEEQVFKLATYGIRCTLVTKSGKICTFYDKFMRECNNDQVPALIQQLSHPTVYFPELRGDSIISVDCSEFFSSVMTRKGKIYWWGLLPSKERQDFKQKLNKESSNNCSIAVNNKVQLRKHLPGFPGALVFKSSETYGPQLGRLLSHETEEGTNQSAVKIKVERVPKVVTSQPNSGSASPIVNLHSRVESPLPEGAASPLQLIAQEARSSSPHTSIRNQTRPETPVKSNPNVETWDVNDVVFLESESKVLGTVAAIDGPHVIVKVDNVNISSDSSLRVFKVSELETVMEDTALENDVASTSTSITSSSMYRGCIQSTPKCILDSSRASNAANKEVLTGLNPIAMTTTSTGISVLVQHKESNKAFFLGPAIDSGNNEKVFTCCADLTLSRANDDACVTVESESVASEEAALTAKPLKSETIGQKRKHPAIEESDDNGNMSSSLHPIDNGRPTLHKSQGSGVILLCDKNGCLYPRPFGTKLSEPCAIDLPPLHCLGLGQKLGYTSKCEAEERILMAFLVFKEQKLIPAIQSGIVSKVQDVLVFIEQSCMITHKGKTAACNTGVKKLAREADSGKAWSPKPAAKENSDEVLKTPVFSHEVMSIINEHTSSNQNVMHVCCTNPAYLTTEAQENEAVDILLAELNKGLSKSTPPSKHIEVAVLDKLLNHRILATKFISMLKDRDAKGCTPFMLSIQCHNFKAALYILDFVAKNKGKQFGDCEISLETMIFPPTFSGITPLHAVALACTENLPASGLGNSLTVSNLPSGYTPRILLKLFQSRYPSAYRATIPPLAEAKKYPRAKTPKQRLLEKAKNEKGNTKKMESTKKVTLDPTSTPGVTPRLGPGGGNRIPTVGNRRESLQGMVTFSDPKELRQALIEMDKHMVSSETMVPEGGLASLVQHVLHVKLTELESDEDDKMEMEVGIGGGVYNVSTASGTAKISRKTQTIDSTSSHQGSAEDDLICQLFARVLAYHEMATASNQQEETVLSFFVNNSRWLKLTSHQKQRLLKYSTKLIGSQTDDTTKQPRSSTPDLSKASNDITAEIKIKGSSGSSAAIESNLLAQLDEISSSFKSLVDTLAALEGKVAEEMEEENVETDKTTKPEGPDNEGASSTAGNLIDFSAPSPEESVSEKDEVLPILIQLAQNWPCVATTILGYYPELTRESPMESSDGDSHEGPRGQDGTTRYVPSRSCSIDGFVVELLANADKSVLITLVETIIKEMNKYPQELLLEVTQQCQDTGGPYTPGRLAITVGMKFLRAVVRQMSVHLSRSGVSYVDLRSRLASSSSSSSPSSSVTFGSDQNSSVEFKHKARMILKSFSWLGIYELVQAAEATVLPVREGVAKAQAKSTGASISNNIPTHTVFPGGRYGGRRPVFRGRRYAGRRPGIRVSQYDSRTTNQEAMLRTASRLLNSNQTATVQQCHGTRLAALTEDSSSPLRRQASTPPISLRGYSRATRRRESLMDSDSDTDDETGNLFRSVMDEDNEMDIEDSDSSSVAMATGLNIEHPYAWALDGRLFGAGENNSQNNLQINFTHYINNIVTPPSVHTGNCYLTRMYSRLVKEAIDLINSNQSEETTASKETIVTEEPVLQVLAINQDECGNILEQVTSVLDVTWVWLAKVLDVVEGQLQHGEGFDTKRYLATLQRPEDSDFTPIPRSSSTNRPGSTPEEYLMFLLRSHTNEHDDTLPVIDMLCYEHMVYILDSFIYCTKRWPKSQRILDRSISSISSMDGEESTSGVSFTDVTPANSETGLHSXQTNPRRRRNKEREDCIKFYGMNVAGKDRDEFLNNIQATLQQKSRMLVPKATWEVFTHNVGTLRMKSVEEASQAGRTRTDVENALPVTFDRVSRQPYPSPLVHNWSVDQVIERWKISVDLFSRLFLADGPGAERDSFLAARAGVAGRLARFRRTIVYLRESVTADSQQGGLAFGGLAGRVGTTLSIAVKRIRLLEDTLRILGEMQPFHYSNFRAKFEGEEGSGPGVNRGFFAAVANALKSDDKLPPETTSLLHEPGKLPEQSGFYAPKPFASRESTIRNYEQLKTRRLKMFTAIGRFLGLSLWFNNTVPLNFSRHVIKFLLDRDVTWEDLIFFNADLFEGLSRMMIDAAHPLMTSERFQATYCCHFETSVGGTTEELLPDGSQIPVTPSNIFKYVRLYATKVMVGCVEEELRCMRNGLHDVIPSELLVTLSPEDFQLLLSGGTTDIDISRLRTLITFTNSNGCSKDILERFKRWFWSIVQKMTALQRQQLLYFCTGSAVLPVMNDRRDPDQDLSITVDVISGNTKALPMATTCGQRMSIPLYPSKRILKKKLLQAIQCQSYGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPU6</accession>
    <name>A0A6P8IPU6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin-45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568892.1">
        <property type="nucleotide sequence ID" value="XM_031713032.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IPU6">
        <property type="interactions" value="2594"/>
    </dbReference>
    <dbReference type="GeneID" id="116303481"/>
    <dbReference type="KEGG" id="aten:116303481"/>
    <dbReference type="InParanoid" id="A0A6P8IPU6"/>
    <dbReference type="OrthoDB" id="5959043at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568892.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="56898" checksum="B0505FF9599C1E70" modified="2020-12-02" version="1">MMAGAILAEPQAMAIARTPEELGRKSHSKDEHGIDYRKIPRSSGDGMEHSGNGTERTNHPKNVQQSHHIYKAHKXKKESVQMFVTGQEEQQKEQTLSSISEVSDRQKSETDYTRKTVHKIENDYKHFQEIQRRKDLPDISMLVQENEEEFLSVNKTMLKEQEKELDDHGSEIGLMLSDLDYPMPENETFNTITDEYREDMDNNRDSKFSYTEMQGVIRDLEERNAKLVEEKTKLCVQLGLQTQVNSDIKKLLVAAVGDDLDNSLEGILMKNAQSAVEIRHWKTLSEEYAEESDKLAIECDVWRTKFMASRMMSDELTSWRTTLYAKYKQTQNALQRILNERAELKKHLVTTKRLLHSLGYLIKSGNSSYKSTEILDEAHSTHQQSVLELASITSCLVHDLAVQVQDLFSSSSIPAEALSLTEEAEKQTVEPTPAEKFAIQVLSSDVELHTEGQQEESTVMKRMGKQYIGNSYQSRLMTNSFRVTFDCCDRCKGAVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ06</accession>
    <name>A0A6P8IQ06_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Upstream activation factor subunit spp27-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568967.1">
        <property type="nucleotide sequence ID" value="XM_031713107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQ06"/>
    <dbReference type="GeneID" id="116303548"/>
    <dbReference type="KEGG" id="aten:116303548"/>
    <dbReference type="InParanoid" id="A0A6P8IQ06"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568967.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29266" checksum="44015E0105D3AE82" modified="2020-12-02" version="1">MVDSAELSVDSLKTAIGDILKSSELSSLTSRIVRNNLEERFNISLKDRKKEIDELLMSMIEENQDQKNEDGDVPTNGAVDSEQESQSEDEDEEPATKKAKKEKKSSVSKSGATNKQMSKKTESRENKDDDDAEVARKLHESERGLRTRKQPAKRTQKNSTKKEPKPKGEKSRTGFGKPMILSPELAEIMEADQLSRSEVVKKMWQIIRERNLTDPKDKRYHICDPQLLKVFGTKRVRTFSMMKYLKQHIKDPALIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS74</accession>
    <name>A0A6P8IS74_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116303645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031569088.1">
        <property type="nucleotide sequence ID" value="XM_031713228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS74"/>
    <dbReference type="GeneID" id="116303645"/>
    <dbReference type="KEGG" id="aten:116303645"/>
    <dbReference type="InParanoid" id="A0A6P8IS74"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569088.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="63913" checksum="383E5F0563AAA03E" modified="2020-12-02" version="1">MSRVHREVVVIGAGWSGLLACKYMLEEKLSVVVLEKRPEIGGVWNYSDDPSILTVMKRTQCTSSSSVTEISDFPMPDEMGEFPRHAQIYKYLNDFCDAFALHPHIVLSCGVVQADKIGDNWEVLGEDGNIYIGSKLVVCAGVHQKPNRELENTLFSDYTGEVMHSGTLKSFIPEHIGKRVMIVGGGETAADIVEEWYEGGAGQIIWSIPRGQHFFRKYSKILPNRKPQTLDKASSRAIKTIAPYTKGKPGLAWVCHWTTAGSLLAYQGHGIPEWKNEAEFFHFFINKNGHVLDLVDYKHVVPKGAIDGAEGKKIYLSDGTQAEVDVIIQCTGYRTEFPFLPPKYQVPLINNYKFIFNVEDPSLAFIGYVRPIVGSIPILSEVQSCLTARVFSGVVHLPDNGDLVNETNKDTEFWSNYFKDSSKRLSTLVEAFTYLDDILVKSGRCVSWVELFKDSPRDWFTTMLSPGCSSYMRLTTKGEEREKALANLRRRGQGCISPLHLLLIAFCRFIWFDWWLIQLGKVKYMFQTNKFCKKVQDYAVVRFANWVWTAPKRWLFDNKTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITA3</accession>
    <name>A0A6P8ITA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116303983 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116303983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569490.1">
        <property type="nucleotide sequence ID" value="XM_031713630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITA3"/>
    <dbReference type="GeneID" id="116303983"/>
    <dbReference type="KEGG" id="aten:116303983"/>
    <dbReference type="InParanoid" id="A0A6P8ITA3"/>
    <dbReference type="OrthoDB" id="10412242at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF49">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569490.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24324" checksum="412719F408C4CAB0" modified="2020-12-02" version="1">MVPSRKFYEVEQRSRKIFTWNMEYIKSKMGILKIIEIIFTCVAFSCITVSKNGFEDDFLEEHKTRYKSMQILNIFGFLVAIFIVVSVSCTQSNQDFLLLLKILNMFLCIIMVFGCFISAIVMSKEATHEYDSVLYKTNHGKWRWYTNNTIAAVVVDFLAAAAFFIDGIMQIREHAREAQATARRRPRTIGEKFLDFFDQKIRTVESWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITJ1</accession>
    <name>A0A6P8ITJ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116304888</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116304888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570536.1">
        <property type="nucleotide sequence ID" value="XM_031714676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITJ1"/>
    <dbReference type="GeneID" id="116304888"/>
    <dbReference type="KEGG" id="aten:116304888"/>
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    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056691">
        <property type="entry name" value="DUF7789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25044">
        <property type="entry name" value="DUF7789"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7789" evidence="3">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7789" evidence="3">
        <location>
            <begin position="170"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031570536.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41013" checksum="B1A30DC085751CD2" modified="2020-12-02" version="1">MDYVNHDNKIESDADSDSNSIDKSLREQTTVTAIGKTKTFAGLEREEWLFVTISLVNIIITVGFTIKCMVDVHSNSPDFTFAIILLVNAAFCFFYAIHGVLREREFEIYAYIAAATVVFTYIIINMAVKPNHITAIKWARFGTILVFAPFNIYYGIVVARGFGFLEFKTVGAVVALQKMYRKAGIFSCLLKFDFQLAISLAVLVIYNPILLNLTNKVILGVGIPFQFIWSVLGWIMMRKELKYLVLVFIPASLVEPGYIIYRLDEDIRNWESNTNGTSKGNMTAISASSTTNNDKDTLIYCFIVVAAIALLVRVLVLIALKFVVDNFGKGLRESVYNLPVSDDQPPLLPRKRDIAKCCGIVCCGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV18</accession>
    <name>A0A6P8IV18_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-related developmental regulator 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116305168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570884.1">
        <property type="nucleotide sequence ID" value="XM_031715024.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IV18">
        <property type="interactions" value="1932"/>
    </dbReference>
    <dbReference type="GeneID" id="116305168"/>
    <dbReference type="KEGG" id="aten:116305168"/>
    <dbReference type="InParanoid" id="A0A6P8IV18"/>
    <dbReference type="OrthoDB" id="686784at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006921">
        <property type="entry name" value="Interferon-rel_develop_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04836">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon-related developmental regulator C-terminal" evidence="3">
        <location>
            <begin position="369"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031570884.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47079" checksum="B5EF4EA24D56AECB" modified="2020-12-02" version="1">MPKGKGKRSDRQGKSKTRASPRRSEESLAVEDDEAMSTTSQNSLETRSGDDVNNEGNDDSLEEIEVTFEHNLEDYLDGAAQKSAKGRQTSLIALQKALKSKVLTEFVASRMMTFQDLVXKCLKRGQAEDRVLASSIASLVCIQLGVESEGFFKVVKPILTMIIQDPTASIGARASCCSALGLCCFIAAEDIEDSQQCAKVFEGVFNNNKTITPVVAPLYCHAVLAWALLLSVAPEAEAYXTVRKFLQRISCILGANDISVRIAAGEALALMYEKARAVDRSFVGEKARFCEQLKDLATDSDKHKAKKDLRNQRSSFRDVMRAIEDGSVPDETIKFGVEYLELYSWTVRRQYSAFKECLGLGMPVQLQGNELLRDIFELGPVVNLEEMQLQKVSKFQRNQYNSAASKARTLVRGKNRDKRNVSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW71</accession>
    <name>A0A6P8IW71_ACTTE</name>
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        <submittedName>
            <fullName evidence="6">Fibronectin type III domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116305484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571272.1">
        <property type="nucleotide sequence ID" value="XM_031715412.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116305484"/>
    <dbReference type="InParanoid" id="A0A6P8IW71"/>
    <dbReference type="OrthoDB" id="5982258at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028237946" evidence="2">
        <location>
            <begin position="23"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="127"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="237"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="332"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571272.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48439" checksum="CFB1163E8BC87719" modified="2020-12-02" version="1">MNRTLSFLGGVLFFALSFLVQRSNENGFASPPLNVKGTATGGYYKSEITLSWSRPTRINGSLTGYTILYGRTDRQTNETISVEPSVTTFRIENLLPYRSYAIFIRANTDHGDGDWSSRVVIVTPQGAPSDVCHVTHINSPTPNSIYLEWDPLDPEHHNGVLIQYRVGWLLENMFSDYKFIVLKNLSXRHYTITGLLPYRLYYLGVVADTEKHGFQINRKFLAKASQLRTKEDVPSQAPSNLRASLDCYSYKLQMSWDSLPSDFINGRLLGYKVMIKQEKQEYHNTTASNEKLDLSVDECKNYSVKVAAFTTPGTGIFSETTPVLSSCPCGIPEPLYSSLTIXSEEGDPVNLPCEYQGRPEPAMYWLHGRQRLYPKEEEVLNSDVNKVGRQFANGTWHVSRAEIKDNGVYTCVLNNSYGVARTDVSLHVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW74</accession>
    <name>A0A6P8IW74_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase TRIM71-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571277.1">
        <property type="nucleotide sequence ID" value="XM_031715417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305489"/>
    <dbReference type="KEGG" id="aten:116305489"/>
    <dbReference type="InParanoid" id="A0A6P8IW74"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="363"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="521"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="570"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="663"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="710"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571277.1"/>
        </source>
    </evidence>
    <sequence length="774" mass="87560" checksum="82DBD6F97E172B25" modified="2020-12-02" version="1">MDIQSILDNLEELLTCRLCSNIYKHPRITPCLHSFCCECLNQLSFSRPYQESIDCPICKFEIRKPEGGRFDSLPPSFFLNRLLDVYVAKRRSYSEASCGNCHRNLLLNSFCFSCGSFMCEECLNAHHIITRNSGHRTVTLGKLKIKDYEDLLRRSTFCAHKFNERGIVEYFCYDCDACVCHVCNVAIQHKHRIVDIDEAANEQKIKLREANAKLKTKLKSLELGINNIEFRSIEVQEQIDYTKKDIRTKIGNLIDILKKHEEDMIQEVERIXKDKQENLTFQLKMYETMHKQTKGSIDFTEELLERDLSEEILTIKNHVYGRADLMDSVVVGTNPAENERVGYVANTEAFESIQKESLGHISTSLTEPLASTAEGNGLSDVSAGEEVYFTIITRNAQGEIYYSEIDHVVVEVKSDMWGLLDTSIKNYRDGTYEVSYIPRVPGVHRVQIEVSGQHIEGSPFRVFVKQPVLTPVKSFGSHAQEQTSGMLLQPHGVAGNMLGQIXMSDSLKHHIQVYTSDGTQMLEFGQEGSNDGQFMHPMSIAFDKAERNIFATDSDNNRIQVFDIKTGRFLKKFGTEGNGPGQFNGPCGITIDGNDRVIVTDWNNHRIQVFNHDGKFLFKFGDRGSERLVHPRAAIYHDFESCFIVSDTGNNVLKVFDQNGKFSHVIGQPGIRRGELCGPRGLAIDKNNNVVVCDFENHRLQFFKTDGTVLNSFGTSGKGIGQFAFPLSISIVGGSKVIVSDWGNNRVQIFKCRDETESPSNYSASNLSRRESYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWL8</accession>
    <name>A0A6P8IWL8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571524.1">
        <property type="nucleotide sequence ID" value="XM_031715664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWL8"/>
    <dbReference type="GeneID" id="116305696"/>
    <dbReference type="KEGG" id="aten:116305696"/>
    <dbReference type="InParanoid" id="A0A6P8IWL8"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571524.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15798" checksum="976D074F7E3CCE2C" modified="2020-12-02" version="1">MASTSTLVINEEPEIVPRNKIFIKPKNECFDLRLKCCVPFAFTFLILLLLYLLYNTQSCVLYIDGIRNATLEKDGNCSSVQLKYVNQTDHEVRSEVVYQRLNGHLIVFIVCLVMSWLVFVQRLVPNGKERPCELSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXR6</accession>
    <name>A0A6P8IXR6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116305114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570808.1">
        <property type="nucleotide sequence ID" value="XM_031714948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXR6"/>
    <dbReference type="FunCoup" id="A0A6P8IXR6">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="GeneID" id="116305114"/>
    <dbReference type="KEGG" id="aten:116305114"/>
    <dbReference type="InParanoid" id="A0A6P8IXR6"/>
    <dbReference type="OrthoDB" id="5983039at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="11">
        <location>
            <begin position="271"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="946"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031570808.1"/>
        </source>
    </evidence>
    <sequence length="1157" mass="130222" checksum="7066E856F7B7EEAA" modified="2020-12-02" version="1">MTKGRAILLSVIGPATYILLRNLVSPSKPTEKSYIELVSALRNHYQPTISITVQRYKFHTRARKTNESVPDYVSKLKKLAEKCDFKDTLNDMLKDRLVAGINDEKIQKRLLIETDLTFEKAYNISVTEELANQDAHALQTPTGSGPVNKVGCSPKTAPNKASYTHSAHPMSSGAYKQGNKHCFRCGDKSHTAPKCRFINAKCHYCSKVGHIEKVCLSKQKIQQPKKERHEQTNAVEAELNLDEDNSDLFNIQSDSVTPPLHVDVIVDDVQMKFQLDTGAGVSLINQTDFVRHFGNTPLDPASVKLRSYTGNKLTVVGEKLVNVAVGDQSARLPLKVVEGNGPPLFGRDWLQEIRVPWKKIFNVDIVKQPPELDSLLAEYDELFNSELGCLKGVEAHIDIEEGATPQFCKARPLPFAMKKKVEDALQKLESQGVIEKVVHSDWATPVVPVVKAKGDAHLCGDYKVTVNKVAKQDKYPLPLVDEIFASLSHVQETALWSSCAVGLFQRTMENLLKGLPNVSVYIDDVLVTGRHDTEHLSNLRGVLTRLQENGLCLQMTKCQFMLPEVEYLGFKVTKDGINPTESKVRAIKEAPTPTNVNELRTFIGLVNYYARLLPNLAHRMAPLYKLLRNDEAWSWKSEQQSSFQKIKKMMSEDVMLAHYDPDAELVLSCDASSYGIGAVLQQPGPNGELKPVHFASRSLTSAEKNYAQIEREALGIIYGVQKFRQYLLGRTFTLETDHQPLVKLFVEHTAIPQLAAARIKRWALILSAYSYKIKHISSKENACADYLSRAPLQEPPDLSDLPEQEDVLLIDEELLSQLPLTAKTVASETQKDPCLAKVLQSTREGWPSKCDDDKLQPYFSRKTELTVEQGCVLWGSRVVIPSTLRPTLLLDLHSEHTGTVRMKGLARQYFWWPKMNDEIEQIAKNCASCQETASAPPSLPVAKWNWPSGPWKRLHIDYAGPYMGSMFLVVIDSYSKWLEVIPMKSTTTTATIQQLRKVFANLGLPEHIVSDNGPQFSSSEFKEFLMKNNIRHTLTPPGHTASNGMAERYVRYFKSQLKKMEKDEGTLQDKISRILLTYRCTPHPTTTESPAYLLMRRQLRTRFSSLRPSLDSQKDAETFEQNTSCLPKFAVGDKVYVLNLRAGPRWLPGIVIEVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXV2</accession>
    <name>A0A6P8IXV2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC116306355</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC116306355</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572259.1">
        <property type="nucleotide sequence ID" value="XM_031716399.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572260.1">
        <property type="nucleotide sequence ID" value="XM_031716400.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572261.1">
        <property type="nucleotide sequence ID" value="XM_031716401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXV2"/>
    <dbReference type="GeneID" id="116306355"/>
    <dbReference type="KEGG" id="aten:116306355"/>
    <dbReference type="OrthoDB" id="5976204at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06031">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="2">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572261.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28752" checksum="BF210636170CE625" modified="2020-12-02" version="1">MTAILPTTTFHAFGMEDQCLDDSFFTDGWENASDDFAFLCSNLVEQDAFPAKDKIPRGIKRTRDDNEVVQNPQQVTDTCSPTATRSNYLNGSTDSQRQGRFLIQVSFEKLRRVEDPESSLRRSVLINNTLKLVHREVYGVKSPFGLTSAMTMNVDSQIMGNSPMNLQPSRKRAKHFLNEVNRNSCFCRRKASEEEGTITPEEKNCERCTLAQVLNEDLEDDVFQNDNIHLEKESSIFSELDSVFHSFVCALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IY52</accession>
    <name>A0A6P8IY52_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enoyl-CoA delta isomerase 1, peroxisomal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <dbReference type="RefSeq" id="XP_031572094.1">
        <property type="nucleotide sequence ID" value="XM_031716234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306180"/>
    <dbReference type="KEGG" id="aten:116306180"/>
    <dbReference type="InParanoid" id="A0A6P8IY52"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000049">
        <property type="entry name" value="Enoyl-CoA delta isomerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572094.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27411" checksum="BF0CD4E509484AEA" modified="2020-12-02" version="1">MASKGVFVEFRNNFAILWIGNGENRFNSQYVKDLQSSLDQVEKNEDVLFLIXIGQGKFYSNGLDLDSLVEMNERDLHSFSSALHALFLRTLTFPVPTIAALNGHSFAGGAVFATTHDYRVMRTKQGWYCLPEIHLKLKFSIGMMSILRAKITDPRVQTDSIIMGKRYTAEEALSSKIVDQICDNNELLEKAIEFGWKIVGNEKFNRKQMADLKSDLYQNVVEDLKLSMKIQTENTDTLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ62</accession>
    <name>A0A6P8IZ62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epithelial discoidin domain-containing receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572474.1">
        <property type="nucleotide sequence ID" value="XM_031716614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ62"/>
    <dbReference type="GeneID" id="116306533"/>
    <dbReference type="KEGG" id="aten:116306533"/>
    <dbReference type="InParanoid" id="A0A6P8IZ62"/>
    <dbReference type="OrthoDB" id="6049633at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027669849" evidence="1">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572474.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31871" checksum="61274AC6DB6E900F" modified="2020-12-02" version="1">MGRSHLKHHLRTVLFALLCPLLFVASQSCGSSYSQSNFKLVGHTIRTLSSSSSDECMSECAAQPNCNSINFEETSKKCELNKANHLSNPEGLTPSFGSAHVWQYINYRMRSPAFCSDKLCGGRKLCLLKNDGENYECSECEDALGMEDGRIPDSAITASKNDSSSFNGKFGRLRSRNWLIENGGYYFYIDLGKTMIVTKIATQGCDWGSKRGYVKKYRLGYSTDNTTWVEYTNNGTDVLVANTDESTVVTNSLQPNVKARFLRMSSAYSVEGDFIRVELYGCPNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZC7</accession>
    <name>A0A6P8IZC7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116306598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572544.1">
        <property type="nucleotide sequence ID" value="XM_031716684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZC7"/>
    <dbReference type="GeneID" id="116306598"/>
    <dbReference type="KEGG" id="aten:116306598"/>
    <dbReference type="InParanoid" id="A0A6P8IZC7"/>
    <dbReference type="OrthoDB" id="10353425at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572544.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31985" checksum="D8BC5CF7C56304EF" modified="2020-12-02" version="1">MCGTFQSKFKRNNKIAPVPCPFELEVLKRAKIQIEKEKALLKKEIAIQTGSSLLFLDTESRRSKTPACVAYDLNLDGNVVQKGLKATCPRRLASDPKLPVLTREMLLEKQAQAKENRNKQLENKRKGAALKSLRAREKKLEEEEEKLNKIAKINEKLCKADANRQAQLEGVKTKAKKSSNNTRSKIAEAQNFAKAQQTLVQSDRKLKEAQTKREKAVNKVVRKQRQREAQAQKVRQRAAKQMQECVRVFDLEVDSHFYASDSESDKDDMWDAAFWDRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J082</accession>
    <name>A0A6P8J082_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 1K, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116306880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572872.1">
        <property type="nucleotide sequence ID" value="XM_031717012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J082"/>
    <dbReference type="FunCoup" id="A0A6P8J082">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="GeneID" id="116306880"/>
    <dbReference type="KEGG" id="aten:116306880"/>
    <dbReference type="InParanoid" id="A0A6P8J082"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572872.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41400" checksum="56881BB28E649ED5" modified="2020-12-02" version="1">MWSKGKLHVLASKNIRSCALRTLCRTKTTEAFQSGVLKRCISSPTASSNKERQTTLRLWSDSGGYDAVSNPFDDLGAWHEAEAKSFLHNVSVESVGSSSNLGKKLVNEDRYKLLELDPDLYYFAVFDGHGGSEAVDFVHNRLHKIIKRLHKNNKDLEEILAAAFEECNHELEKHIRFLISEKGHHPSIAGGGTTATVTLLRDGLELAVASVGDSRALLCRNGNTICLTNDHHPIRADEHERIVSHNGWVDWESNHIPRVNGRLAMTRSLGDFDVKPFGVIATPETTVLKIDHKSDAFLELHTDGVSHVMSSNELGFLVRMCSDPEQAANTLTSCALQYGTEDNVTAIVVPLGAWGKYCSHNFMRNNIMRINCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0Q4</accession>
    <name>A0A6P8J0Q4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116307045</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031573044.1">
        <property type="nucleotide sequence ID" value="XM_031717184.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J0Q4">
        <property type="interactions" value="2984"/>
    </dbReference>
    <dbReference type="GeneID" id="116307045"/>
    <dbReference type="KEGG" id="aten:116307045"/>
    <dbReference type="InParanoid" id="A0A6P8J0Q4"/>
    <dbReference type="OrthoDB" id="6764942at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14092">
        <property type="entry name" value="STKc_MSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="34"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="303"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="401"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="40"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="407"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031573044.1"/>
        </source>
    </evidence>
    <sequence length="755" mass="85100" checksum="E3C9A6992C12168F" modified="2020-12-02" version="1">MTNNGFGNSGFVHLDVQQTNLTEAQDEKVGLENFELLKVLGTGAYGKVFLVRKRGGFYTGKLFAMKVLKKATIVQKAKTAEHTRTERQVLEAVRRCPFLVTLHWAFQTEAKLHLIMDYVNGGELFTHLYQREKFTEDEVRIYIGEIVIALEHLHRLGIIYRDIKLENILLDSEGHAVLTDFGLSKEFSAPNSGERAYSFCGTIEYMAPEVVKGGSKGHDNVVDWWSLGVLMYELLTGASPFTVDGEKNNQSEISKRILHNNAPMPHDLSPDAIDLLRKLLQKDPKARLGAKGAHEIKKHPFFKCINWDDLEAKRITAPFKPRIRDELDVSNFSEEFTDLAPLYSPAAAPKTADRVFRGYSFVAPSIIFGENEFNVASQRPEHGLVDYAAMFEGSHFFQNYRITSDVLGDGSFSTCRRCVHLRTGMEYAVKXISRRCDPTREIQSLRICQGHLNIVTLYEVYNDAFHTYLVMELLAGGELLERIRKKKTFTESAASVIMKKLVCAVEYMHQKGVVHRDLKPENVLFVDNSEESEVKLVDFGFARLKPPESQPLQTPCFTVNYAAPEVLDQTVNHTGYNDSCDLWSLGVILYTMLSGQVPFQSSGSWYRSSAGFVMQRITQGDIRFEGQQWQSISTPAKNLIQGLLTVDPKARLTIQEVLHHSWLQGGNLLPHTPLMTPGILEQGHKRTYVESALNVTYDAFNKAQRQGFTLMEVENAPLAKRRKLKKTTSSDSHSTTSTCSEQSNSGGLSPLQNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2E8</accession>
    <name>A0A6P8J2E8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LARGE xylosyl- and glucuronyltransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116307961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574151.1">
        <property type="nucleotide sequence ID" value="XM_031718291.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J2E8">
        <property type="interactions" value="904"/>
    </dbReference>
    <dbReference type="GeneID" id="116307961"/>
    <dbReference type="KEGG" id="aten:116307961"/>
    <dbReference type="InParanoid" id="A0A6P8J2E8"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06431">
        <property type="entry name" value="GT8_LARGE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000229">
        <property type="entry name" value="Glycosyltransferase-like protein LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000016">
        <property type="entry name" value="LARGE xylosyl- and glucuronyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574151.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="87124" checksum="058E36CEAAF71A10" modified="2020-12-02" version="1">MHGSTAWRMLLAGSMGVLKVRVLGVLLMLSLGSSVVLWWITPPVHHSQGSDMPRIQISKHASDNTMLWKKLASLQNQNDDLKNQLKLANQRLHDVNLKLVTLKDINQDQSANKTSGCPDTSSLSQCEVIHICVVCAGHDATRQAVTLVKSIIFYRHNPLHFHFLTDSVSEIILSTLFKTWKLPAVQMAFYPITDHMDKVKWLPNKHYSGVYGLMKLVLTEALPEALDKVIVLDTDIILASDIAELWRLLDNLTGKKAIGLVENQSDWYLGKLWKNHKPWPALGRGFNTGVMILDLYRLRQMNWKHVWRLTAEKELMNMLSTTLADQDVFNAVIKNQPHIIFTLPCVWNVQLGDNTRSEQCYSRVTELKVVHWNSPKKLLVKNKHGDFFRNLYLTFLEYDGTLLRRWLFHCEDFQPVDQSNSTLTSSEIAVVTKIPNGIDSEXPCYEFKQQHFIIHRTHLYYLNYDFTTAVGDHDVTLVAQLSMDRLQMIEALCQNWAGPISLALYMSDSEAQQFLNYALNSPVLKSRTNVGYHIVFKEGQFYPVNYLRNVALDNTRTPFVFLSDIDFLPMPELDAYIRQMLKASYAGKKAYVVPAFETLRYKLSFPRTKSDLLSQWDLGTVFTFRSNEWSKGHAPTNYAKWRTATTPYPVQWEEDYEPYIVVPKNIVRYDTRFVGFGWNKVSQIMEVHAQGYEFMVLPNAFIIHLPHSLSFDIFKFRSSHQYRRCIKELKEDFKKYLLDKYGQDKFPELELDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6A8</accession>
    <name>A0A6P8J6A8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Collagen alpha-1(VI) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116308919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575299.1">
        <property type="nucleotide sequence ID" value="XM_031719439.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575300.1">
        <property type="nucleotide sequence ID" value="XM_031719440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6A8"/>
    <dbReference type="GeneID" id="116308919"/>
    <dbReference type="KEGG" id="aten:116308919"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653293" evidence="1">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="38"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575300.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26041" checksum="DE1C864F536F1606" modified="2020-12-02" version="1">MFFRIAVLVLVWGHLETGEGRSITDGDKKQVTCNKQIDLGITLDASASIGEENFKKYKRFSKELLSRFAISLSRTHVALSYFSMYHHIVATFNKSHTLEEANSIIDDMVYENSASKLSNAIVELHFAVFAGKCSGVRPKGSGSKMVSLFVTDGFSTSGYELTNSRAKDFHNYGIEAFAVYPNGKVHENILRSIASRPIAKHLFRLEEKQEKRRSLIDKIVRQICFGSYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6F0</accession>
    <name>A0A6P8J6F0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116308955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575329.1">
        <property type="nucleotide sequence ID" value="XM_031719469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6F0"/>
    <dbReference type="GeneID" id="116308955"/>
    <dbReference type="KEGG" id="aten:116308955"/>
    <dbReference type="InParanoid" id="A0A6P8J6F0"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028370281" evidence="3">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575329.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29288" checksum="C947C3C84C4B89E6" modified="2020-12-02" version="1">MEFLVLILLLVLLYKVDHITSTNTHDDRNPGLLFDNHPGYLLSLPANMTKVKQITTKVSSKMDCVFACVRTSWCRSVNFKITAEMDGRHICELIATDNYTNTKYLKQDEKFTHLNIKNPCADEPCLNQGICIPHSNGFDYRCKCKEGYHIGNNCQKVTYLLGSPAETCTSACASRGMSCIEVGAFPNNALSIFHSINVNCKTPEDTNWYLYKDQPNYVVASHWSERCTGFKGLNEFEHSTHCGIGGNPIVQRLCPCKEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7W7</accession>
    <name>A0A6P8J7W7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin subfamily A member 6-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573175.1">
        <property type="nucleotide sequence ID" value="XM_031717315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J7W7"/>
    <dbReference type="GeneID" id="116307164"/>
    <dbReference type="KEGG" id="aten:116307164"/>
    <dbReference type="InParanoid" id="A0A6P8J7W7"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573175.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35267" checksum="0E1774C3E20A5B89" modified="2020-12-02" version="1">MAEKSKTGFFRNYNRKEKERKIHLEEKARKLEAKLKDHDENCQPKIHDLEEEIQRLKEEITRLEEEIEKLDKEANTLREKIKTLEMKNGDLEESNTFLEKEANEVKGEVGKLKKKFELSEDELVIRQLCSSVQENLLRIVLQENFNEIQNKRTRYMEEYISSQIKDKGERKRARLRWKDLKKEVDWNEFLIKQLKPVKTSGNETAHPPLTEEVINAAKNKLEKRKKLGPEMVKAVDQLKEIWEKTNQKLTQGTSFQDKAGLSTSSLSLPGTSHGNALSGHSSFHKKIRGKSLSQPNIFWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7X2</accession>
    <name>A0A6P8J7X2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3-ketoacyl-CoA thiolase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573180.1">
        <property type="nucleotide sequence ID" value="XM_031717320.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J7X2">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="GeneID" id="116307168"/>
    <dbReference type="KEGG" id="aten:116307168"/>
    <dbReference type="InParanoid" id="A0A6P8J7X2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="273"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031573180.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="41880" checksum="63536F811E5EF251" modified="2020-12-02" version="1">MALARPVYIVAAKRTAFGSFGGKLKNLTATVLGEHASVAALEAGKVDPAIVDSXIFGNVIQSASDAAYVARHIGLKAKVPVSSPALTVNRLCGSGFQAIISGAQEIILGDSDIVLVGGTENMSQAPYAVRDARFGTRLGIDLKMEDTLWQGLTDMLAKLPMGVTAENLAEKYNITREQCDEFALLSQQRWGAAQEGGRFKEEIVPITVKGKKGPEEFAVDEHPRPQSTLEQLSKLPPVFKKDGTVTAANASGICDGASALVLVSEKAVKDHGLTPLARLVSYGIAGVEPSIMGIGPVPAIKTALESADKTLDDMQLIEVNEAFAPQFLAVQKDLNLDMEKTNINGGAISLGHPVGTSGARITSHLVHEMRRQKLQYTLGSACIGGGQGIAVVLENMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JBV3</accession>
    <name>A0A6P8JBV3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized hydrolase YOR131C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116307931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574120.1">
        <property type="nucleotide sequence ID" value="XM_031718260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JBV3"/>
    <dbReference type="GeneID" id="116307931"/>
    <dbReference type="KEGG" id="aten:116307931"/>
    <dbReference type="InParanoid" id="A0A6P8JBV3"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031574120.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29946" checksum="99C5F9EFA2F09A74" modified="2020-12-02" version="1">MGSQENSRSQESTSQSEEMLHRISYIITRSSSSTTVSSVHKEQAIMPINGIVFDLDGTLTIPVLNFKELRKKLGCPPLPVDILEFVRSKPENEKARLLKVVQDFEDEGNRNMVLQPGVHKLLKFLTDNGIKRALLTRNERPCVNTFLEKLGDPSEYGGPFSHLLTRDFTPSKPHPAPIHHICKEWGIKPCNAVMVGDHFHDINCGKKAGTVTILLNNPKNGACKESADFNVNSLEDMISLLKNNSMVVQREIPLPAHVHAQEGTEKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0L6</accession>
    <name>A0A6P8H0L6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116286789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116286789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031549228.1">
        <property type="nucleotide sequence ID" value="XM_031693368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0L6"/>
    <dbReference type="GeneID" id="116286789"/>
    <dbReference type="KEGG" id="aten:116286789"/>
    <dbReference type="InParanoid" id="A0A6P8H0L6"/>
    <dbReference type="OrthoDB" id="5985780at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549228.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52199" checksum="101848BC953BA442" modified="2020-12-02" version="1">MVNCFVPDCKHHSESHTCTFFTFPSKKKNLEEHKRWIRLIRRDDRQPGAHSRVCSCHFRNGQKSFGPEIFERNADKLFPCQDGPPRNKKKKSSPLKENQLNIQEILEEYQEQQNNNSASDTCDTKISTNEVLLAAELDMVKRDLEEKQQYLSYMSTHYSVSNLSTEVIRMETGLPTGEVFNIVVSYAARFKDSIAYFSGWKVDSLSFEDQIFLTLMKLRQNYTNLHLAQLFSCSHSTISNIIITFVHVLHELLFKDIMTTIPSRDKNKLSAPSSFSQFISCRIVIHCTDIECAAPGLMSQQSLTYSSYRGMNSFKVLVGVAPNGVITFVSNCYPGSISDKEIVKQSGLINHMQTGDLILTDKGFLIQDLVPKGIYVNIPPFLEHGKFTESEIKVTKSIARCRIHVERANARLKDFKILTFVPPYLRCHSDKLFQLCAALVNLQFPLIKEGCTNFEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0W8</accession>
    <name>A0A6P8H0W8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116286877</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549323.1">
        <property type="nucleotide sequence ID" value="XM_031693463.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H0W8">
        <property type="interactions" value="2362"/>
    </dbReference>
    <dbReference type="GeneID" id="116286877"/>
    <dbReference type="KEGG" id="aten:116286877"/>
    <dbReference type="InParanoid" id="A0A6P8H0W8"/>
    <dbReference type="OrthoDB" id="413649at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000001">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000564">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="510"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="949"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="192"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="669"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="753"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031549323.1"/>
        </source>
    </evidence>
    <sequence length="1231" mass="141570" checksum="285B25984D19C486" modified="2020-12-02" version="1">MGYLERLELENFKSYKGRHTIGPFMRFTAIIGPNGCGKSNLMDAISFVFGERTQSLRVKTVKDLIHGAPVGRPVGSTAKVTAVYAEEDGTEIRFTRKIVGSGTEYRIDDKVCTPQAYTSKLESLGILVKAKNFLVFQGTVESIAMKTPKERTAMFEKISRSGELGEAYEKKKADMIKAEEETSFNYHKKKGIAAERREAKLEKDEADKYNKLNLELADCLMESQLFKLYHNEQEVSHLTTELRNKSRETEKLESKKQSIEHQLKGKKQENAKLAREMATIEKTIREKEVELNQKRPAFIKAKEKTSHVIKRLETSKKAYEKAKEARQRHLAEIDELKNSLEEVRXLAQKYEEEVAEESQGEDLELMDSQVEEYNILKEQARKETAAIRQQLDRINRDQQSDQEAVDAIRQSKLDMQNRKKQLEEQSVQLRERIDKLEDYLNTNVQTVEKLKDDYSKLSDEVEGANTRHRDVSVLLESVQEELNEARSDKHESARHQKRKEVMESMKRLFPGVYGKLIDLCEPVHKKYNLAITKVLASNMDAIIVDTEKTAKDCIQYLKEQRAERETFLALDFIQVKPISEQLRQLGGNTKLVMDVIRYSPSVVKKALQYACGNALVCDTMEEARKLAFGGSERKKTVSLDGTLFQKSGVISGGVSDLKAKAKRWDEKQVDGLKKKRDQFLNELKDLAKHRRKEPELQNLQSQIDGLDNRLKFCRKDRDNIENQTLAEISRELRIIDGKLKALEPDRARLLASMGEREQEIKRTEMEMNQVEDRVFQDFCDTIGVTTIRQYEEKQLKAQQERSKKRLEFSKQESRLQNQLDYEQSRDSKAQVKKIEKSIKNDEREIKELKEXEKQQLKVIDFETNELEKLRLDRSAKKSQIDEKDLEVKEIRKALNAHLKDVTSIQKQVTSLDTQLEQKKADRHGLLKSCKMENIMLPLKRGNMEDIDLGETSASQPEEESTSMEVDGSSSQGTRPSTHEREANIILDYSSLSRKLKEHEDPAEVRNMANELANKVTKLQTTLQRIQAPNMKALEKLEGASSRFQETNSEFEQARSTARKAKIEFESVKKQRYDRFMDAFEHVSTRIDDIYKELANNPSAQAFLGPEDAEEPYLGGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFSIHSYQPAPFFVLDEIDAALDNTNINKVARYIINQTREHFQCIVISLKEEFYTRAEALIGITAEPDNECTVSRVYTLDLTKFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1N0</accession>
    <name>A0A6P8H1N0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116286861</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031549306.1">
        <property type="nucleotide sequence ID" value="XM_031693446.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H1N0">
        <property type="interactions" value="1596"/>
    </dbReference>
    <dbReference type="GeneID" id="116286861"/>
    <dbReference type="KEGG" id="aten:116286861"/>
    <dbReference type="InParanoid" id="A0A6P8H1N0"/>
    <dbReference type="OrthoDB" id="5966611at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000619">
        <property type="entry name" value="macrophage colony-stimulating factor 1 receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1414"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="23">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="165"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="358"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="547"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="658"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="765"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="871"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1100"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1198"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="1307"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1486"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1818"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1834"/>
            <end position="1862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031549306.1"/>
        </source>
    </evidence>
    <sequence length="1910" mass="214683" checksum="EF24285136DE89BD" modified="2020-12-02" version="1">MPAAIKDSSYPTIPTKRVVVTGSETSKDLICTAKGQLISSVFWYKAGMYVSKHNQSVTKNNNTWTNVLQIRHITKDDDGKYECRVLNRGNDFRSGFWPAFAVVFVSDSSCVTLNGSFPDPADKAGYIKCTNGKAARKECPQNTTWNDDKKICEKPVFRLDWIHRPVVLPFMDKKVGTSLTVDCRLSDPTVEVSLYQKDTYSRRRYPDGCKVTYSRQVFTVHALVILDVGSYYCRAENVTEKEEVFLKVDPGPSIWYGQGDINFITALGSSIDFECKASIMPESNTFLELSTSYRITTLVPDGKKVIKRGNTFKIRGVDRDQAGNVYCKTTSSCGGQAEGYKIGRLIPVRQPKGMTPNPSIKPTKQALDLGQNKSIIFNCSVGNTKAASFSWFLDDEQISDEHVYVSSNKTYSYLTVSDKTLTRAIQGGAVMDVECRVTSNGAGYWFATAELVIGLDSIITRPLQQTFVHLYGSASFSCSPRTTTIYQNNTKSKTLTPRSLDGAKIIMRRSNTLEIQLFDFDDVGLYYCSLEDAVPVAHFVLSGTDQPIVVGWVKIISTKDPDKDNKIIIDQSASVNLVCYSTYRPRSPSFTWEKTDVAGKKVNITRLTKSWPRWVKQSILEIRNASKQDEGTYTCSLDDNGKQLSDMVKIVVKDPSKPTITLKSPNIICQENDMVDITIQVLGSPPPAVFWKINKEVIASCLPLYGSMLCEATSSAYNVKFKGGSHVLTINKAVHKLNHRDYECVARNMVGKTSKTVSVAVRVKPKLAKESDTIRHVVAKPKDYVKLPCKVLQGYPTPTINWYTAPSSTCKERDPTCKPEDHQWKRIGLPVPKEFVSPPMNETAFYKCDATNALGKDSVVYSVVRMDIRPPKINNFKNKLTVNGSNRLEVACHVEGTPIPDVLWIRKRKTIAACTGDALGISKTCTPTVSSNAERYEIRWLETHSEMIVQSASHMHDGGILSCIAKSQLGQDKADVQIEVQESPKLAKQGEIASYYTQYNDYRTLVIDVVSGNPPPQYKWFIQSADHCRQSNQQCKPRPRRWIPSYLEASPPPGVAGTRSAISLPPSKRNFFYKVEASNAVGADKQIFSVIRTWEETVRPVISKPKGVVFDQEEQLKLVCKASRFDFQGVDWVRKDGKPLPRNRTTTDTRAEDHDILMTILIDSVTMDDAGVYQCLGYTENSTSAASVDITIREFVSPKVSLTNQTVMSTIGQVDLQCRVVAGYPKPKITWYRNDIPLKLKPLGPDGDCASFTNGFYHLDDQKPPYSEHLVICDPKHERNTGWYKCKAENKRNHTQIRKYLNVHEAPTVIITSDASVLLREIGESLEVTCIASGNPEPTVYWLKKADDEREYPVAAENVQSVDGGKVIVMSMDESHYGVYTCRANNTYGNSSASVSVENPSVLSQVQKQSKDQLIAVIIVSIALILFLIVFALILYRRKRMYGGFYLCTTPPLPDLIKSLDPRSPLIEQVHKLPYDPVWEYPRENIVFRDVLGSGTFGKVFLCETEGGLVMDDRSSVNSRYRLAKRKDYRRGSAISLKGNLKIAVKTLKETASESDHNDLLSELKILIHVGAHKNIVNLLGACTKGPKQDLWVIMEYCPHGDLLHYLKEKRDFHEPIWEPPTDDPKTQFSLTELVSTAYQVARGMDFLTSRRCIHRDLAARNVLVGENYVMKVADFGLARDVYKNEEYVKQTPGLVPIKWMALESLIDKVYSQKSDVWSFGVILWEIFTLGGSPYPDLHPTEVYEFLVEGKRMAKPVNCPDEIYALMNECWMHDPDDRPTFKEIVLKLDKIIEINIPAMGREAYLELDNVEDENLNKEEDGYLLPSDVVPSKAPQKEDDEKPYVDIDDPHDYSEIPDHDLSKESNSMIKGSSEGERKSKIKMPGEYEMALKNPRYVNVLNDTETSRTTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3I2</accession>
    <name>A0A6P8H3I2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116287475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550011.1">
        <property type="nucleotide sequence ID" value="XM_031694151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3I2"/>
    <dbReference type="FunCoup" id="A0A6P8H3I2">
        <property type="interactions" value="1222"/>
    </dbReference>
    <dbReference type="GeneID" id="116287475"/>
    <dbReference type="KEGG" id="aten:116287475"/>
    <dbReference type="InParanoid" id="A0A6P8H3I2"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="5">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550011.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33227" checksum="68804B2BC5746B5A" modified="2020-12-02" version="1">MATSDDLNDFNEEAFYQQLLLEETKYLQKKAGDDSIEFIPDPGFVLKSKISSEGREKKVFVNICTSKHIPKAKEVTEKELAEILDSEDPMRYRVPLSLGEPHAEIDKSGNGCTVYDIVIHPSFLKKVQENSFFQNFFLTVVFQGLEEKYGLELDRNWTILKNKKSMGKVQSHFIRNKSKPVIMDMENNSQNTSQPVVKDGAQPNKIQEIEPDVRPTPEPKYRVLIEPPEGVPEFVVLEISLPGVKSAKVIDLDVSGDRLVLQVNTDLYRLDIQLPHDVDNEECGAQFNKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H451</accession>
    <name>A0A6P8H451_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclic AMP-dependent transcription factor ATF-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550226.1">
        <property type="nucleotide sequence ID" value="XM_031694366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H451"/>
    <dbReference type="GeneID" id="116287694"/>
    <dbReference type="KEGG" id="aten:116287694"/>
    <dbReference type="InParanoid" id="A0A6P8H451"/>
    <dbReference type="OrthoDB" id="2596881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14721">
        <property type="entry name" value="bZIP_Fos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000010">
        <property type="entry name" value="Cyclic AMP-dependent transcription factor ATF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550226.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19195" checksum="12F949877B4CCA65" modified="2020-12-02" version="1">MEAGEVPPVLNLNQNPEVNMTSFAGVGTSSLCMDTTSEEFVIDVKNESPYFTLDENSADMEYIYKTPLDGSNPHLSETVSHEELERKLLRRERNKVAASKCRQKRKEHVRNLVQASDQLEAQNSTLQSQISKLHDEIKQLEFMLDSHSCSRHMAGNHGNSCSDKSQVPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6S2</accession>
    <name>A0A6P8H6S2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289343 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552094.1">
        <property type="nucleotide sequence ID" value="XM_031696234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289343"/>
    <dbReference type="KEGG" id="aten:116289343"/>
    <dbReference type="InParanoid" id="A0A6P8H6S2"/>
    <dbReference type="OrthoDB" id="5983789at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552094.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33958" checksum="B22228722458A706" modified="2020-12-02" version="1">MASSSGSLDRTALYPAPKRITVTSCGDGIEVRLETEKSDASTEEEKNNNNNKESSPTEPXPAFTADVQGEAVIPTSDYFETELETKTASFVITDEEWGLVTPRKMPSGGRLLTGPWAHILSNHLRESNPYCSFAFHYNRLKTEHSRKRMAPFFKAIGTCRVKECSVMVRLLIRGINESKRLVDVSYNGTLRHRVPVQYKPDHVRNEKSNGMLLLGVCRDSEPGPQHLPNLSIASEISNETEELPTIASGISKENEEMRTASEKSKENEEMPTASEVSKENDEMPTTASEKSKENEEMPTIALXNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7H1</accession>
    <name>A0A6P8H7H1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ragulator complex protein LAMTOR2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551416.1">
        <property type="nucleotide sequence ID" value="XM_031695556.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H7H1">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="GeneID" id="116288728"/>
    <dbReference type="KEGG" id="aten:116288728"/>
    <dbReference type="InParanoid" id="A0A6P8H7H1"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000004">
        <property type="entry name" value="ragulator complex protein LAMTOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551416.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15593" checksum="53EC1AC5B2EEF5CC" modified="2020-12-02" version="1">MFNNSSSKEVELPDFPPNAMLRPKVLSEVLGQANTGGVVNTLLLNSDGSILSHAGSPDKDAKVTAAIASSIWSAYERNGRLAFHNEDLQVVFMDCENGKVAIAKVGNLLLCLYAKETVGFGMLKXKVQALRSYLEEPLRQVVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8D5</accession>
    <name>A0A6P8H8D5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Perlucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551498.1">
        <property type="nucleotide sequence ID" value="XM_031695638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8D5"/>
    <dbReference type="FunCoup" id="A0A6P8H8D5">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="GeneID" id="116288798"/>
    <dbReference type="KEGG" id="aten:116288798"/>
    <dbReference type="InParanoid" id="A0A6P8H8D5"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027635308" evidence="1">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551498.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20787" checksum="504BA579B13F0E50" modified="2020-12-02" version="1">MYKVLLLTAMVLMENVFLFGPRKTAAAASSRMLPGVVYQPCHHGWVTYEGSSSCYKVPPHPTNNWYEARKTCLSMGSDLVKITSTQENNYVAMLVHTYFPSTNYMWIGFLADAKRKFTCVDGTPLIGQYSNWASGEPSTKGEDCGSIFLTKIHDMKWNDLSCLWTTKIGYVCEKERPKIVQRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8Q5</accession>
    <name>A0A6P8H8Q5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116289159</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551896.1">
        <property type="nucleotide sequence ID" value="XM_031696036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8Q5"/>
    <dbReference type="FunCoup" id="A0A6P8H8Q5">
        <property type="interactions" value="2630"/>
    </dbReference>
    <dbReference type="GeneID" id="116289159"/>
    <dbReference type="KEGG" id="aten:116289159"/>
    <dbReference type="InParanoid" id="A0A6P8H8Q5"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000140">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031551896.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33869" checksum="03CF1C16ED44B546" modified="2020-12-02" version="1">MAASGDVDELFDIKNHFFIGNYQACITEAQRKQPSTRDLIVEKDIYMYRAYTAQGKYGVVLDEISQLSPPEVQPVRILADYLQNHKKRDSILNTIEKQLNTSDINDYYLLMAASIYLHEENFDSALRCLHQSDSLECSALTVQIYIAMNRIDLAKKEIKKMQDIDDDATLTQLSLAWFNLAVGGEKCQDAYYIFQELADKYSSTVMLLNGQAVAYMHQGKYEDAESLLQESLDKDSNNAETLINMIVLSQHLGKAPEVSNRYISQLKDGHPLHPFTKDYVAKEKDFERFSTQYAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8T0</accession>
    <name>A0A6P8H8T0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein mono-ADP-ribosyltransferase PARP14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116289189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551926.1">
        <property type="nucleotide sequence ID" value="XM_031696066.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H8T0">
        <property type="interactions" value="1212"/>
    </dbReference>
    <dbReference type="GeneID" id="116289189"/>
    <dbReference type="KEGG" id="aten:116289189"/>
    <dbReference type="InParanoid" id="A0A6P8H8T0"/>
    <dbReference type="OrthoDB" id="5989023at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060335">
        <property type="term" value="P:positive regulation of type II interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF70">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="959"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551926.1"/>
        </source>
    </evidence>
    <sequence length="1345" mass="150747" checksum="7486B45D03A48C7C" modified="2020-12-02" version="1">MERNRVLITGLPKGSKISRKDLIMYFQSNKKSGGGEVIDTKYLDQGEAIFTFQNEVVANNVLAKEHVINGHAIHITVPTRNQRTETQPWSTGDIDDDPASDENSASSSDEKETGDPEELCTVRVSNLSHRTTKDSIQNYFENKNKSKGGDVRKVELQNTLNVAIVVFRYHKDAKRVXEYEKHKLDNARLSVALVIPKDDKEKLHKGKKKSISDTPSDEALPLEFVVSGMSKITTEDALINYLENTRRSGGGEVEDLSFDEVERVAEVKFRKVKCLDQLLGNQHRLDDTNLQIEVKEPEKEIPLDPFKVHVKGLSPITTIDGLGLYMEKMSNKGVKYVQLGSYSNAIISFKEPIDFEQLAKRIENDIKGLDGCKPMLESVPYCCCIQVSGLDVKTTKDSLELYFENERKGCGVEPREVDLQGQGRALVYFXDPSVIDKALSKRHVLEDAELQMEMFYPFLSEEKATKKRHNKKKKTEEIDIDPDIMACISRCYSDELQDLLDEAGIDLEWTTXKESAVMTEXEETTNKGQPWGKRIKFLQEYFGDFKCQRISVEAKVWDEVLEAIKKELTSKDEFXDTDXTTHESANEIRITGKKDRLQMAVSAVETLVRGIQDDKALQDSIETXVEKDLXSGKLALLKISDLFQDLQASNKHVDMEVKENDGEVIIKGPRKCLQEISIELYKFFSKVKEEVLELPERIIGVLQTPKGRXYVCKSLSQNQIQAVLVHGQRKGKNEASIFAXNKDQARQAMKLIESFSTERSIHLKDENIPVIQSRKWNELVASFKEAQTVVNIWFEEQCQTLWISGVEQDALECFTVVECYIEKNTILEDNVAVSDGCSRFLFQRFDNEIKGLHAGLRDAFVKIKPGDCGEIRLTGTREGIEKSKEFVMSLVQKVCDEEIKIDKPGMKKFFKSSKGTKVIKAIEAENKCTVELVDLDQLEEQGASSSKGMGGSKRVANGEVICSYTTMEKKKLVVYKDDLTKHPVDVIVNAANENLQHVGXLARDIVRVGGQGIQSECNRYXNTHGPLIEGHVLETGPGQLPCKXIIHAVGPRWDSFXDQGDSGSRRKKNILKFAFENCLESAKNYRSIAIPAVSAGIFGFPLDLCASILVETVITFFQKNPHCNLSEVHFTNIDDMTVKAFFDEMKRQFGKERTFNEGMDKPTLVSSNLYQESKSTSSSFPASSSGKVLTTPEGISIFVSNGDISQEKADVLVNTAGEDLNLQNNACARSFCKAAGPNLQRYCSKISPVKVGEIGVTKPGNLQCQHVFHAVCGDWDSGKGEKILRGILQKCLSFAERRGANSIAIPAIGTGVLQFPRKVVARISFEEVISFSKSRPNSLKEVKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H918</accession>
    <name>A0A6P8H918_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289266</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552021.1">
        <property type="nucleotide sequence ID" value="XM_031696161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H918"/>
    <dbReference type="GeneID" id="116289266"/>
    <dbReference type="KEGG" id="aten:116289266"/>
    <dbReference type="InParanoid" id="A0A6P8H918"/>
    <dbReference type="OrthoDB" id="8939918at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552021.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18207" checksum="65C8891822B0E7F1" modified="2020-12-02" version="1">MAMQDCIADIRRWMQADRLKLNDEKTEFIVIGTKQQLAKVSVESLCVGNETNAPSDKVKNLGCWFDTHLKMDSHINNCCRAASFHLFNIRRIRKFLSYDTVQTLANALLTSRLDYCNSLLYALPANQLCKLQRVQNAAARLICNISRFDHITPALHKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAG8</accession>
    <name>A0A6P8HAG8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Keratin-associated protein 10-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552138.1">
        <property type="nucleotide sequence ID" value="XM_031696278.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289381"/>
    <dbReference type="InParanoid" id="A0A6P8HAG8"/>
    <dbReference type="OrthoDB" id="10371694at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="D or N" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="2">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552138.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="64281" checksum="5E4C86C7A994B4D3" modified="2020-12-02" version="1">MGHCTDTCPDYCCTLRTLPKLTKPHPAACPAICATKCQPFCLIRCCKGGAKQFNIDLKIPETQMTTTPRPCPTICFQTCLPDCPIRCCQESGAQKLGSIAXXESDDDVCPSSCIKECGPNCPXKCCAALPKQISVLIHSKHXKHGCPITCSKXCNPDCPXRCCSGNPXXVSIIVNXDPSLSGCPSSCSQSCLPPCSTKCCNGAENPKPVTIIIDPEGKSSACPPSCXKNCGPDCPVKCCPGYLTTSNNTGVSTXXSQCPKICXNKCLAFCPIKCCKKKTPSCPVVCFTNCISSCPLKCCAKTTSSQPNCPPGCKVSCEPSCPLRCCTDLVXXTTTPSTNVNAITCPTICAITCKPFCPVKCCSXIMTSKPGQLXXXLAFTTNAPCPAICKEICKPDCPXMCCXGLLSATAGPIITVTTPSTSTCLPICILTCLPTCPVKCCPAITTPHAQRPTMLSTKSESTCPSSCVTTCLPECPIKCCPQLQAVNAYKTTATCPPSCSVVCLPKCPMHCCSPEKSKETFPTVATLPNNKPCPPSCAITCLPMCPNFIVPIRRISEHDRRFCVLLNVKLDVQETVIHHVVTTRIDRQVVKYGQREGTFQKAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAP6</accession>
    <name>A0A6P8HAP6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">VPS10 domain-containing receptor SorCS1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family. SORCS subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549570.1">
        <property type="nucleotide sequence ID" value="XM_031693710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAP6"/>
    <dbReference type="FunCoup" id="A0A6P8HAP6">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="GeneID" id="116287099"/>
    <dbReference type="KEGG" id="aten:116287099"/>
    <dbReference type="InParanoid" id="A0A6P8HAP6"/>
    <dbReference type="OrthoDB" id="5949766at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028279879" evidence="8">
        <location>
            <begin position="23"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="9">
        <location>
            <begin position="754"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="9">
        <location>
            <begin position="850"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549570.1"/>
        </source>
    </evidence>
    <sequence length="1146" mass="130377" checksum="F630077973655C37" modified="2020-12-02" version="1">MAFYYHYLTLLFTLLLIYEATSLLHDDISGFKYIVLDKKSNNAAFYSSLFKNGKIDQNKLTSLSTRGKRSLTDSPILYSSNSSRSGLATEYEFHGDNHSVAFLHWSGSRSQVIFIFTSNYQSIQRNPGGSVHVENAYLWRSTDYGTSFQREDQTKFNKGSKNINGIHFCKGNNKRVVVYDKKGKWVYISDDEGDSYAAYQVNFTPQEILCTRDSGKNFLVAFDETTSKLYHAKDDGKNWRFICNDVVQYFWGTNSTTLFIETQQPGHKYTSVLKYIHLPGDASDVKVFDALLGGFVTRSFKVNGKYMFVKKMYPQMAMYVSYNGSSFKKAMFPFNLDVKDFNVVDASEDEVLSCIRHDDYYNLYISDKTGTKYSLSLRRILATSSYQWGRTLKLADIHRVRSLRGVYIANIRRKDAIVRTFITFDKGGEWNRLAIPDNVQCKELECGLNLHMVHSERYYQISSVLSSESALGLIMAQGNVGRYLNEETDVYLSSDGGLHWNKILNGSHDYVFGDHGGLIVAVALGNYTKKVWYSCTEGKFWSTIEMEKNVRAYGLVTEPGETTWVSNIFGQHLTKSFEWLSVKLNFSSVFERKCTDQDYTLWTPNDERMKGQCLLGEHMVYERRKADICCYNGKQYEREINQTSCNCSLEDFTCDFGFQNNDISDSCVPISEDLIVPKVCPEFQTYMRSSGYRKVAGDRCVGGIEKDFYPVKTLCPVKVPSGLSIVLKRTTVAAHIPITFNLKQEQGSTGSTWYLWDFGDGSKPINVTGITKAQKQNHTFTDHGSFNVTVTASNSMGTTSTRIAVQVIDAILRVLITPPHAVLIGQPAPFNITLSSQHTERSWVAEHGYVHFVWTFEPKQRPNLTWENEVEHTFTKAGVYTVKVEAINAISRQYGQVTIHVYDDLRTLRISFDDELDNEYKDSQKWRDEFRNMFLAKLTSVVFIPKSRLEVYVLPGLPTQVDVSIKPKDTNDNHTMDQIVDRIKVVIKQKRLVIQLSEGKSTAAVYAELLDNSGKKPIAVDDKQGNQDTRLAIAIGLAAGFIVIFLVGIIFYVYRRYMWIYRRYSRLSMNGSRPDGFIPLHPGGQESVGYNADDDVVRYAVPETEDINDSEDELLLDDHTEPGRLSLVINEDTQQDNSQSTDAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB48</accession>
    <name>A0A6P8HB48_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC116289537</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116289537</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552341.1">
        <property type="nucleotide sequence ID" value="XM_031696481.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552343.1">
        <property type="nucleotide sequence ID" value="XM_031696483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HB48"/>
    <dbReference type="GeneID" id="116289537"/>
    <dbReference type="KEGG" id="aten:116289537"/>
    <dbReference type="OrthoDB" id="10279607at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653028" evidence="2">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552343.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27854" checksum="EF9219A31A3656DE" modified="2020-12-02" version="1">MLRLISLALLGICLPLIVAFPANNAAVKVASLTGPTKYAACKSLDCPPFRVVQKIAPDVELREYSRVWWASAKAQAPRINRNVTTPLYWLLRGYISNSNKQLQTLKSKFCNNGSQSANKGILCQRRTLKMGVPVTKLIESTKTGMKEVTMSFYLSVPSPPRPSDSKVWLEYKPLQVYVKIFKGRSFYIRMGEGHAHILANDLIRRGVDGTAFYPPSAKYMTAGYDGPFIPRRLRTNEVWLIKKPSSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBQ2</accession>
    <name>A0A6P8HBQ2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tonsoku-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116289755</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tonsoku family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552558.1">
        <property type="nucleotide sequence ID" value="XM_031696698.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HBQ2">
        <property type="interactions" value="1089"/>
    </dbReference>
    <dbReference type="GeneID" id="116289755"/>
    <dbReference type="KEGG" id="aten:116289755"/>
    <dbReference type="InParanoid" id="A0A6P8HBQ2"/>
    <dbReference type="OrthoDB" id="5806726at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="323"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="550"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="834"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031552558.1"/>
        </source>
    </evidence>
    <sequence length="1326" mass="147499" checksum="7307DD9BCA65EF67" modified="2020-12-02" version="1">MDSSLKRELKLYQKRKAKAQDKGDLEEESKMCYASAELLTQHGFYGDAVKEYKQALQVAEAREDTIGSAVAHRMVGECLCALGKYKDALFHQNLHLQLAKSSNNLVEQQRAWATIGRTWFVYSDSAVDAXETEESLMESQKAYLEALSVCDKLQGITSETELLEMRARLYLNLGLVYDSKNDTPSARKFIDKALYIASFVLMVHLKMGDFLLARRTLKKAYKISPSQAGAEMEGLKSNLVAGEYQCQCRHMCDTWCNVAQVYENSGESYEEIERAYLTALKYAEQANKLPIQVRVYRYLADTQRKYDHMKDYAETMKKVEELESKFGIEEESDEDEEEEDKEDDDENDDDDNDDDDIIQREMLLPDSDEEYDNEDENDESVIKHRTRTGARTKLSKRNEKGETPLQRAAIAGDTELVRRLIEQGADINTRDYCGWQPLHEACNHGYTEIVRLLLAKGAHVNDPGGPHCQGVTPLHDAAQNGHIEIVKLLVENGASLLSKDTKGNTPLDAVLSAQESEEDRDLIGCETEAAAGRRQVVNYLKKISLGGTSLNRTEKKQPEMRRRNRLFLDNFDDNNNDDDDDDDDGDDDDDDDDDDDVVRGPPTSKITESRSVHDPVSDFSQGTSSKIALREKNYLETNVESDVEVESVSEDGDISSEGLEDESPYFSVDNDFNHDKQPTRRSSDSERISIDDSQDISTDWHSRDHHNTSSYLDTISGKRLDANSSRQTTALVSERDLGSTSAIESASEDSDWLINDMPERPTKRRRTNKQATLSTSLALSRRGPSTYNSKSSRSKNTSNISKKPSRPKQTRLEVRRTPSPTYFSSSPVSQQSSNTLFQGHSLGTSSQGDSAVRQTSSASTPGGAPPMRIRVQIQGKTFLIPCPEKNDQERKTMAWLSEQAKLRYFSAFGLRPVLALQTSEGAFLSPEDKISDVLSNNEQIVASVESWDLPPVAERYKTACISNNCEIKKDIQALLQAEPQISVISLGNLALQDYHVLPLARALQCHDRLVKLILPGNKIGDSGVQHIAASLSTLPNLSVLDLRSNGISHKGITYLANALSKTNDNQEITSSNKLEELNIGYNALYDMCGSSLTNILVTCSQLITLLLQSCCFTGKLVEPSKPLAEALKASSMRYLSIAHNNFEGQGLCDLLSALPCQALRHLDVSSTVCNKSEVAMAIDGLAQYMEKDDCALQNLNLSNCCLGNRDMEPLLVSHSQTLVNLSFSGNPGIDSGFLELFLDAHRTTSSRVQYINLSACNINSPISDDILGLLRNNSTDNLMELNLSFCPLNQTDKLCIAETWKEGAGGANEREAIVQDCLCILGTSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCI6</accession>
    <name>A0A6P8HCI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-selectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550392.1">
        <property type="nucleotide sequence ID" value="XM_031694532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCI6"/>
    <dbReference type="GeneID" id="116287837"/>
    <dbReference type="KEGG" id="aten:116287837"/>
    <dbReference type="InParanoid" id="A0A6P8HCI6"/>
    <dbReference type="OrthoDB" id="5976046at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028145449" evidence="1">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550392.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24107" checksum="7DAF491F22E68C31" modified="2020-12-02" version="1">MGHRAPRIIVAITLLLIVWQWESILAIDFIDIADCSCYSLHQNPKSWQDSNKICQENGGTLVSMETEEEYQFITKTIQSLDVGKNEWFIGLRRISRTDYWKWISGHDMTIDKWRATRTSGTGDCVKMIKHYKGRGLFDDVTCDPRYKYTFICEYKQAQKCSNITSTIIEKRCFSKRKQVTTKENTMTRGYIEDTAFRMGYVSNLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCY9</accession>
    <name>A0A6P8HCY9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116290587</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116290587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553516.1">
        <property type="nucleotide sequence ID" value="XM_031697656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290587"/>
    <dbReference type="KEGG" id="aten:116290587"/>
    <dbReference type="InParanoid" id="A0A6P8HCY9"/>
    <dbReference type="OrthoDB" id="5982218at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031553516.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23298" checksum="7BB2F5EF8237BB4A" modified="2020-12-02" version="1">MDKVLRPERFHADPSSAGASKSWIHWRRTFENFLAVLTEEGLDKFRVLTNFISPTVFEYVEECTDYESAIETLQNIYVKPTNEIYARHLLATRRQQTGESLDEYLQALKTLSKECNFQPVNATKYCEEYIRDAFISGLHXNQIRQRLLENKTLDLKTMFDQARALDSAMRSSESYFAPQPVTAVAAAPEIVPQNPTQVDSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE39</accession>
    <name>A0A6P8HE39_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288287</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550912.1">
        <property type="nucleotide sequence ID" value="XM_031695052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288287"/>
    <dbReference type="KEGG" id="aten:116288287"/>
    <dbReference type="InParanoid" id="A0A6P8HE39"/>
    <dbReference type="OrthoDB" id="5987064at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550912.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="58725" checksum="A6A42DFFDFFA1FE5" modified="2020-12-02" version="1">MASISLVCMITKDCGLKASTTLQDHKPVATGDLRRWCPSAEAIWTRTPVSGHIWRCKPNPGPASSFGVKTRGLSIAHLNVRSLLGKLDELKLLVTSTSKSFDVLTLSETWLNSSISDAEIQVPGYTCIRKDRPDGKRGGDNNSPKIDYSASNVILLGDFNVDVSSKKNPLKQQLINXTRSLDFTQLIKDPTRVTETSKSMIDLILVNNEHRYTDSGVVNPSISDHFLVYCVLKVGKPKASPRTMEYRSYKNYDREAFLKDLKDVPWNFVEDSDDVDASVLTWNKLFLDVADAHAPVKKRRISGIQCPWMTSKVKEAMHNRDFHHRKATTTGSRNTVKSDIKRGKSKYIDLIKDSKGNGNNLLKAINKATCRKQDQASIPNCIVSNGVQYLESKSIVNVLNNHFASIGQLLAKKISSLFPFFSPNITSDPDQSFHLSSVDETFVLNQLKSLKTNKSIGLDNISARLLKDSADVIAQPVTNLLNLSIKLHSFPCIWKCAKVIALFKTGDRTDATNYRPISILPNCNSTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEE8</accession>
    <name>A0A6P8HEE8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 38-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031550945.1">
        <property type="nucleotide sequence ID" value="XM_031695085.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HEE8">
        <property type="interactions" value="2620"/>
    </dbReference>
    <dbReference type="GeneID" id="116288308"/>
    <dbReference type="KEGG" id="aten:116288308"/>
    <dbReference type="InParanoid" id="A0A6P8HEE8"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049407">
        <property type="entry name" value="Usp38-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF908">
        <property type="entry name" value="DEUBIQUITINATING APOPTOTIC INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21246">
        <property type="entry name" value="Usp38-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="438"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550945.1"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115772" checksum="603A9D614E84FAEA" modified="2020-12-02" version="1">MDQILKGIVASDHPEDVKKILIQQLVSKSANEIPEEQCKSIFEISSQWMAKENTVFLNDSGKLILTSWAKHHKEVFQRFFTEEYLLSYVENSQEMSVASVNYIRTSFELLQHTTQIFSLYTIVRHRANIWISQKSDIDFCASVCRLLIEYNHCWPVGDHLVQTCFSLLYCLAKTDLPKSSKEELKTCIRNAGFVAALMNRVLMXNQNYILPILTELFKIISSHGPNPSVAVASVVQFFTPEVIDSSTKMVACSPSVSDENLALALTRMISWLSWPGGRRVDQWIICFLRALAMAKKHNILIQVTLEKLPQVFSRLLFPMVRDSTMGVLSHMLLSFKHSPQAFHLIVENVPDLVKTLKKENTASSKACLQTLAELMHILMYQHSGFPELYGPVLDSLQDFTKPSEAMIKKWLAQAAWSAQAFNQIPPSRMTPKSETGRTGLVNLGNTCYMNSIIQALYMLDEFKCLLMERNTTRAFEKVIYRLQELFVFLKMSQRAAFSPSKFHHVARPPWFTPGSQQDCSEFLKYLLDRIEEEDKVVSNLTELKEKIPHRQLHSNIIEDTFEGKLLVCHRCRRCNYVSYREEVFIDLPLAFPQNSTWVDRDLSNGPGKPLVDQPAENANIPSSDRSLKGGDIGQRPSVPSISSNSKGESESSSESGPSSPTNNYTLPKSSGSQSKVSTYGIGAEDPSISLEEMLGYFFEPEILEGSNQYHCEQCQSLQVAERSVVISKAPRFLVLXLKRFSYNVTTHQRSKILQSVTYPLKLKLSNNIIRVKEEEAKRGSPVLEERHTPPIDKCLNDEKMEAPPSKCTKQDFDCAPPSAPXVADSASSALPLENFPSETMYALTSVVVHSGVSSESGHYYCYARPSGHVVQDDDVTANENNDKSSGGKKPLHLVGTDNHSWCLFNDSRVSSAKFETFSEITKRFPKDTPYVLIYKNISKYAGSSRGPSVSGVAMETKECKIRQDLLDLVNLDNLLYLQEIEHESRMLTKPKLTPSRSRDNDDDDDSGSSNSSCGPGAGYSTPFNRFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEF2</accession>
    <name>A0A6P8HEF2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase TRIM33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554809.1">
        <property type="nucleotide sequence ID" value="XM_031698949.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HEF2">
        <property type="interactions" value="1708"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116291743"/>
    <dbReference type="InParanoid" id="A0A6P8HEF2"/>
    <dbReference type="OrthoDB" id="5959490at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554809.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33635" checksum="990AC4BD221EBF86" modified="2020-12-02" version="1">MAVVKSLKDITDTFEEQLTCSLCLDVFTQPKTLSCLHSYCTRCIAQWYQKSENQGEYRMECPMCKTTIVVPDGDPSKLPSSFYLDSLLDLLHGMKSKANEPVLPHCLSCEQPRVLVGFCAQCNGLICEDCFNAHQLFKEIQDEHQPIKLDQFKEENVNSFIKNQMLCKFHEKKKLEYYCQERTCKLSVCQKCAILNHQNHQLQSLEEAGQDSRKLIIGAMNQVEQRKQIDGQELQQXKGNXERIEREIAVAERDVDEVVEMICNMAKEHGIAMKEELQQTLQELTATNHEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFY5</accession>
    <name>A0A6P8HFY5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-mercaptopyruvate sulfurtransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551500.1">
        <property type="nucleotide sequence ID" value="XM_031695640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFY5"/>
    <dbReference type="FunCoup" id="A0A6P8HFY5">
        <property type="interactions" value="724"/>
    </dbReference>
    <dbReference type="GeneID" id="116288800"/>
    <dbReference type="KEGG" id="aten:116288800"/>
    <dbReference type="InParanoid" id="A0A6P8HFY5"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000015">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="182"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031551500.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33273" checksum="B772D444914739C2" modified="2020-12-02" version="1">MAVRPLVQASWLQQQLKEGVKHLRILDGSWFLPSAKREPEKEFYQKRIPGARYFDIDECRDKSSKYEHMLPSSDEFSKYVSNLGITNDSHVVVYDNNEKLGVFSSPRVWWTFRLFGHDKVSVLDGGLPKWCAEGFPTESGPLKEESFENNPPFKAVVNENLVCDFDFMMKNIESNNPVQMYDARPIGRFTGEEPEPRRDLPSGHMPKSKSLPYGKCLDLKKKCFKEPEELKKLFTEAGADFAKPLITSCGSGVTGAGLLLGAFLAGKTDGILYDGSWTEYVQRVKPDMILKGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHF0</accession>
    <name>A0A6P8HHF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patched domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554368.1">
        <property type="nucleotide sequence ID" value="XM_031698508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291337"/>
    <dbReference type="KEGG" id="aten:116291337"/>
    <dbReference type="InParanoid" id="A0A6P8HHF0"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="3">
        <location>
            <begin position="282"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554368.1"/>
        </source>
    </evidence>
    <sequence length="895" mass="100321" checksum="2A8B2C74D9F01FD4" modified="2020-12-02" version="1">MEEENTRKQESPKKKCRYTPRALWVSFSTMYVNLLSRCFGVLGTVISRHPFLTVAVALGFVGVCSGGVYWMKVENSVENLFIPQDSRAIKDMNKVKINFPMESRIETVIFEPKESSQYVLSKACLLDVLAVHDEIINTKPYQELCLSQPSTYNSPSFCLFLNPLDIVQFNQSLFSNATRKFEEAFRNKGLMMRNGRPFWYNMRMMFGGLDIDSVSGEISKVDALQLLYFMKNSDKEDKKIMDWEKNVVEKIEKLKDSLSCMKVYINMQRSLDDAVQESATGDIRLITVSYILLISFACIMLGKFRNPLTGHSLLANIGIFAVFLGIIAGFGFTMFVRTPFISIVGALPFLIVGIGIDDMFIIIDELDRVGPQLSVTDTVKVVMXNSGATITMTTMTDXVAFAVSTWSELPAIQYFCLYAAMAIFFAYLMIITFFVAMMTFDXRRVKAGRRDCFPVCRVPXPKEGAPAWDEPRTQTANKLLTAWAKILMRREVKCIVVLISLGLLGSGIYGALNISEDFDTRLLAEDGSPFILFTNAQDRYFPPKIEVSIILDEQVNYTSPETQKDILHLSKIASQNSFYENTTMSWMETLAAFSKKKGLSLEGKNLMPTLRTFLNIPAYSHFREDLRLSEDKGTVKASRILCYIKKSLNSIGQRDAMVTLREDLDNRSPLPAYPISKAFIYFEQYAITSKATIRNLVIASIAILLITSPFLVDFSVTILVFFGFVALVFELFGLMYIWGLSLHGVSMINLIMAIGFAVDYSAHIAHAYIMSSKSSAEERVIDALRTLGASVLMGGASTFIGTMTLAFASSEIFRIFFKMFLGIVLLGLLHGLCFLPVYLTIFCRSSSLKTHDAAITIEPALAESRELAVVTQQPCDNNNVTSYENPVATTEQNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHL3</accession>
    <name>A0A6P8HHL3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552102.1">
        <property type="nucleotide sequence ID" value="XM_031696242.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289347"/>
    <dbReference type="KEGG" id="aten:116289347"/>
    <dbReference type="InParanoid" id="A0A6P8HHL3"/>
    <dbReference type="OrthoDB" id="5984664at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="575"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="655"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="695"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552102.1"/>
        </source>
    </evidence>
    <sequence length="1338" mass="148607" checksum="AD5F12E97B1C2AF8" modified="2020-12-02" version="1">MDDHRIAENRLEKIKIFLGFCLSCSSIGFLNLRKEELIEEYFKMAEFYDGICHQIAQYNRLGIEYENSYQWNEAINCYQKGLAIATKIGDAKSAVVLYGNVGKICQSLSKYEDAIKYHETSLDITKTIDDRKGIANANANLGIALKSIGKYGEAKDCHEKCLKIAEERSDEKGMVDAYGNLGDAFNSLGDTKEAIKCHEASLSIALKIGDRKGEGNAYGNLGVAYYSLSKYKEAIEYLERSLKIAIDIQDKEKQGILYGNLGAVCQSSNEYEKAINYHEKSKKIATEIGDKEGETISYVNIGNSYQSMGEYEEAIRNYNQALSIAKDIGYKYGEEAAYFNLANSYQLMGKEKEALKYYENHLSNAKEMGNKEREATAYLSLGNVFHSLGKHKQAIEYFEHSLNIAEEIACKDIQGKSLGNMAGVSYSTGKYEQAREYAEECIKLSQEIGDKKGVSSAYASLATSLDSLGRAKEAIEYREKQLSIAKDLGDKYGEANAYLGLGIANSSISQHKEAIECHRKALDIAIEICDRKEEANVYGHIGSDFSRSGNYTEAINYLNKQLSIAKERGDIGSEGEANDGLGNAYFHLGQYKKAVRCFETSLNFAQETGNKDSEGTAYHSLGIIYQSLGDQKTAILHLEKSLDIAKEIRRKSHIASVYGSLGSVNQSLGKYESATEYYSKYLTIAKEIGNKDDESIAYGHLGDMSLHFGKHEEALSYFKKLLEIAMKTSNKPNEGSAYGGMGDVCFALGNYEEAIKNREKQLQISVDTGDKRVEGIANMFIGNCYVAQGYSYKIIKDLKKYNECMTKARDFLEDSVQCWEGLYNHSVEEDKWKISFVDTFHLSYKILANVLTEMGENAEALLVSERGRARALNELLSSRYDLPFINSLNTNSFQYSDVETLLSRGTFTLVFYAHQGGASIAAWILSQQKPLVFVQNEIEGHEDQGSFRIPGKNQGQLQSIGTNISKVVNAAYDKMKVREGASCENRSFKTTSIGNKQANCNHIHSGKKSSALLVQQNVAEEINNNEEEQWRCIEEHEEEEEEEGIENPLEMLFDGLVSPVNQYLLDDEVVFAPEGPLNLIPFAALKDPATGAYLSETKRIRLVPSLLTLKVLQECSSQYHKTTGALIIGNPDVGQVILRGKKTQFQNLTFAEEEAKMIGSLLGVEPFIGAEAAKDVIMKRLQEGVAVIHFAAHGTTEGDIALTPTFSSNSDESGSIPKEEDFLLTVGDVQQSGVRPQLVVLSCCHSGRGEIKSEGVVGMSRAFLAAGARAVVASLWAIDDEATMTFMQKFYFHLKCGESASRSLQQAMKEMRAGKYNEPRHWAPFFLIGDDVTVNCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI87</accession>
    <name>A0A6P8HI87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pericentriolar material 1 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555586.1">
        <property type="nucleotide sequence ID" value="XM_031699726.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HI87">
        <property type="interactions" value="2625"/>
    </dbReference>
    <dbReference type="GeneID" id="116292407"/>
    <dbReference type="KEGG" id="aten:116292407"/>
    <dbReference type="InParanoid" id="A0A6P8HI87"/>
    <dbReference type="OrthoDB" id="2125770at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031446">
        <property type="entry name" value="PCM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024138">
        <property type="entry name" value="Pericentriolar_Pcm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14164:SF12">
        <property type="entry name" value="PERICENTRIOLAR MATERIAL 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14164">
        <property type="entry name" value="PERICENTRIOLAR MATERIAL 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15717">
        <property type="entry name" value="PCM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pericentriolar material 1 protein C-terminal" evidence="3">
        <location>
            <begin position="1588"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1152"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1395"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1438"/>
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            <begin position="1533"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1919"/>
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    </feature>
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        <location>
            <begin position="2211"/>
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        <location>
            <begin position="734"/>
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        <location>
            <begin position="156"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
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        <location>
            <begin position="303"/>
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        <location>
            <begin position="385"/>
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            <begin position="425"/>
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        </location>
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            <begin position="533"/>
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            <begin position="779"/>
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            <begin position="905"/>
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            <begin position="936"/>
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            <begin position="1056"/>
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            <begin position="1440"/>
            <end position="1450"/>
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    </feature>
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        <location>
            <begin position="1557"/>
            <end position="1566"/>
        </location>
    </feature>
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            <begin position="1569"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1771"/>
            <end position="1782"/>
        </location>
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        <location>
            <begin position="1791"/>
            <end position="1805"/>
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        <location>
            <begin position="1946"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1974"/>
            <end position="1987"/>
        </location>
    </feature>
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        <location>
            <begin position="1988"/>
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        </location>
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            <begin position="2092"/>
            <end position="2101"/>
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        <location>
            <begin position="2134"/>
            <end position="2169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15717"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555586.1"/>
        </source>
    </evidence>
    <sequence length="2258" mass="248824" checksum="692D2C87F889F5D0" modified="2020-12-02" version="1">MASGGGSPGGRDRKVPKMSSQSELRTKKRPVPRFNTSFDTELSLNTELRRAEDSMNYRSLPNNLGWSLGANGYMPERGTSSGGQRKSKHFEQVKLQEXTASPESPQPVEFKRKKHHTPATIPRTKLPAGTPVAERLALERLRQHLAFGEDELPSRGPSTRGSQDVVTLPSQSSAANNERAQLLARPGGTFQIPVRETNETDTTLAVGGADESAGEQVDTSKILERLKQVRDFLKQATTMFVSMSTGGSDEQRTRDFEQAAKLARLIKHLKKQERAYTSLLQRSIAVEDDSATENTPSLSLHSFSEDEKSETHSARDEELQGLRQQHELLQKMLQQQKQLKELQTRQAALLNLQRDAEQRLAEAEEEDEQTAEGMEEDAIGGGGYDTTSGRSRSGTEASAATAEGSTDDWGFTPEQFALHNFMQRTNEKFRADGDKDRDEGNQRRRKKNQQVVRAEHGPSMDLQSSSDVQPDNEEAALAIADAAQERLELENKLMALQAKKEQMDSLLRELQQLREAQLRKEGRKPQGSSINEAKQDNDDEKPLATTSQKLDDDSILEALEVHEKLKKLQDVRQHLKQLRDMIGHYQESAGTGGDLNLQDGPGMLAEDSAPESGRADETEEERGAVGGAGSSATGPDNSSLDWILNYGIDDPELVSKLRQLHAARERVLHLKQTNQMAQLPVGTSRLHNETSNPQLSQSQTEDLETDGTTTDTESNASHASSSLNALAWQEDPEFQEKITKLNSAKKKLKQLQELVKRVQQFPDGAPVLPTELAELSFDEVDDDDEDEDTEQSSSSSDEEQDEDDDEQAVERNSGVEDEDEDGQSSDRIQNLQGIVVSEQEAEYQLRLQKQKNELDRLLEERRRLLQMQQQLSRLTQEQNEAQKAPAMNENGSRASAEIPAKNPSKARTSNSGSPSLIRTDTFTVNRPNIPVRHVSDSATQTQSIEQPLRTLKSNKSYSVDSGEPPQGGTTSSALVWSELRRQRELHEEKLKKRKHRLLNEKRKKAGLDDVSEGGAYSLRSADVDEGFGVSMMSADITTATWGGSTQPSSTQNDSAVSEDESEGENQEGEIAVEVEDDYPDGIVQAEEEEEERDEQDTYPGGAADVFRSRECAPRNYGIGQVLLEKKRSRGARKKELSWPRIGSDRSPRQRLRQQNFTPAEQLIEEREREQFILEREAWEQQCGQLHGEVAKLTDMCNNLLRDQQSLITALIGRNNLGAGPQMTPGPMPAAVNDSNPFHQYQQKQQEAYQSLQSYFDNQRHLLQQQQVVQTLNQCYMQLNNQQQDLNFLQGKFQQLFSCNSNPPSAGPSPLPRYDMPGASPGYPFAAAANNLGPTFLQPNGMPSFSFSGAPTTFPSLPVFSSAGINTTYSHPTASRPSASNNFTYSPFQTSATANDSINHRDIPWPAPPSSGQASASAAADSIQVPSWMPVFSDASRFPSVHTQTEHTANPETGVPSPRFGAFGGHLSSLASTPAAGSGGLPSSSRYSAVGTSTDANLLRSYDPSAYAEARPTPPTEVVGRSFPTPLRAQAVANLANKDRSSQTANPKRPLKRGFDSVETSSQTSSLPGDAHDPSKRASQDIDRASDAGSEFSLFEALRDSIYSEVATLISLNESRPHFLIELFRELQLLTSDYLRQRALYALRDIVTRFLTEDSLTTGMVDKTAQQTRFQAWAGSNSELTPSETVETSEDEQNCRDEAVSAQVVTEGIYDYVENVESGSTLSTPTSSQTGDAPFASEGLGETVIHFDEALQKMREYERLRAEGKLRQLDTSAGSKGDSKGASNKQMKEDVTTSSAGDMGSDSSFSDVQYPRIDTQALDHQIKSIMSEVIPYLNEHMEDTCTTELMGYIRGLVLSRIRVREEQEFGRFFHKQLASILHDSLSKFEGRKMKDCGEDMLVDMSEILFNELAFFRLMQDLDGSGGTRGRRPFWRQEVESGTDTGTGQEADKEDEGDVEGADEEKDQQPEDSATEETESTTREKPEDDKDDIKDEEEDDDDEEDNESSDDTSSSEDSDAEDEAAADDEGAEQEDTPILKEEKEAEEEELGKDRDDDMAAQFEDMPESSKENASESQQCVKLELSVSESKPFTSAGSGEEDGEESYDDLQSKRTLGECEGGTAAGRDRGQGSESDESDDSNAPQDDQAQATAAAAEAATAAVTTATAATQGADQANRPEHLQNGQLTEDHDDFEVILDDLPTKLTGLTEADLQARIAEEQSRTEGAQGVLRHIDAEPELAGDGNALREPELPANPANDSQVGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ03</accession>
    <name>A0A6P8HJ03_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Roundabout homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555826.1">
        <property type="nucleotide sequence ID" value="XM_031699966.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292619"/>
    <dbReference type="KEGG" id="aten:116292619"/>
    <dbReference type="InParanoid" id="A0A6P8HJ03"/>
    <dbReference type="OrthoDB" id="6088938at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="263"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555826.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43296" checksum="9481E2AA38E00837" modified="2020-12-02" version="1">TVNYPPKILVPPTTQTVVKTRSVSLTCYLEGKPLSNVTWFKDGHPIXPAKDNRISXSSPTSVSNTSATITVTNVNRTDEGKYSCQAVNGVGNDTSSGASLTVNCKFSGSSTPKHTGNKLVMHNIRNTGEYEGRYTCIASSRAGKTEESASLTVLVPPTEKAAALPQGVMLQLGQTIKLKCNVYGDPEPSFVWTKRLPGKTERIMLADQKKAKLVIPDVRIGDAAYYGCTATNSLGSITLKEVFIDVNTSLDIINSRKLFNDNEESSTTIICIASSEAFPVKVKLFKDGIELKTRRDVSNDKQVVTAQLDLTKVSTDDSGKYTCVAKHRQKEVRADVFLTVNVPIKVEMDVSLKNKTFTDELRDNTTQEYRNLTAEFIEEVRYLYMLDYIGALIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ41</accession>
    <name>A0A6P8HJ41_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein KIAA1958-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031556404.1">
        <property type="nucleotide sequence ID" value="XM_031700544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ41"/>
    <dbReference type="GeneID" id="116293149"/>
    <dbReference type="KEGG" id="aten:116293149"/>
    <dbReference type="InParanoid" id="A0A6P8HJ41"/>
    <dbReference type="OrthoDB" id="5975945at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057926">
        <property type="entry name" value="QRICH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25561">
        <property type="entry name" value="QRICH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="QRICH1-like" evidence="7">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="6">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556404.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="52111" checksum="3464D513294F15CD" modified="2020-12-02" version="1">MTVEVQKDNELETTNFADEDEVSTFIRENRNKNTAKKTHNDLRVFYRWAKKIKEIRKIEEIPPNELDKLLACFVVKVRKQNGDEFEPDTLTSYFRSIDRFLREQGKQYSILLDREFNRSREALACKRKELRRRGKGQKPIKAQGLSTDHIKILWQKQQLGNSYPQVLLRTVWFYNTVYLGWRAQDEHHRVRYGDFEVKTDGEREYVEWIKERGSKTRTYENEFFPDRPFNPKMFATDGPRCPVKLFKKYISHVPPEMKKTESPFYLAAIQKPSSEIWYKRQPLGKHSMAQFMKEMCKAAGIEGRFTNHSARRTMISTLRKENVEPLNIIALAGQRNLKSLDSYSEASTEQQHVMSSKLSEHIEGRKLTKDSALSPKVPLQLSSTLTSNPLEPAEQPESNQSMFYGAVFNNCSINFGRDHHALAVEPSPSFKKKFKRIDPLNSDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ84</accession>
    <name>A0A6P8HJ84_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Extracellular calcium-sensing receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116289906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552747.1">
        <property type="nucleotide sequence ID" value="XM_031696887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ84"/>
    <dbReference type="FunCoup" id="A0A6P8HJ84">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="GeneID" id="116289906"/>
    <dbReference type="KEGG" id="aten:116289906"/>
    <dbReference type="InParanoid" id="A0A6P8HJ84"/>
    <dbReference type="OrthoDB" id="6022339at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000281">
        <property type="entry name" value="Metabotropic glutamate receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="634"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031552747.1"/>
        </source>
    </evidence>
    <sequence length="967" mass="107850" checksum="85034AB94CB985F6" modified="2020-12-02" version="1">MRLTTTERLSQRQGQLRRMDFIVTFLILLTTLAVLVGSQQNHPYTCNNPPKLQKQRADLTLGGLFPVHVYKTEENQRTLVLNNYALTWTEAMLYAIDEINNDTTLIPKHELGFDIRDSCNDVSNALGAALDFILEADRNESQENSSSSQCKCVSRSSHVAVIGGAASPISTQLAHIFGIANIPQISYSSTSVFLSNKDIYRSFLRTIPSDTYQAKAIADLLLKFGWTYVSVVASDSEYGRAGMDALKVELKKRSICMAVESVFHPNLKKQELTRIITSLKAHTRAKVIVLWCQRPIAIGFLEQATKLGLSGKTWIGTETWGDSYLLYKLNPKTVGGMIGMVPRLTKHSGFEAHLAKLDPGNSRRNPWFAEFWNNEFNCEIINAEGGNTSLFNAKNNLQFVSSKEYYVYKSNTGDNATIVCPKDKDKGKPTASVLPRNKYTNVMDAVNAVVHAIESMLKCKEGEGMLLSEGKCPSTSPTIRTIDLLEYMKNVSFMGRSGTEVSFDKNGDLKFGSYAIKILQPEEANPSSMVFKEIGFWDGVNGSLEFKGETQYLWNGWEKEIPTSQCNDLCSPGKYSVNGSVTCCWTCVECPGGYAKESRGQGPCTRCPEGYESNVNRTRCVKMTEVYMDWSSGQALCVSMVSIFGGLLTLTILAIFVKHRETALVKASNRELSLIHLAVMFLIFTYPLVLIGKPNRIVCGVRPLYFAILFTISTSITLLKTDRLLRIFRAKNRISSRSHLLTNKMQIMTSVALTFIPVVTCSFWYLFRPPSVIVLNYSENSRIISCSTSDDTLLVIVLIYILGLALVCTYFAYRARTLPENFNEAKFIGFAMFSFCVFLSGLLPAFYSSTGSNRTFVNCLAVLGPAYGVLCIIYFPKVRIILFYPDQNKTEVFRINATTMNLRSRTNSPPANVLRPSPINSPLEDRRVVVSSIGSKEEAEINSARLSPYLDNRRMTAVTVGRGTTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJW2</accession>
    <name>A0A6P8HJW2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Melanocortin receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292077</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555173.1">
        <property type="nucleotide sequence ID" value="XM_031699313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJW2"/>
    <dbReference type="FunCoup" id="A0A6P8HJW2">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="GeneID" id="116292077"/>
    <dbReference type="KEGG" id="aten:116292077"/>
    <dbReference type="InParanoid" id="A0A6P8HJW2"/>
    <dbReference type="OrthoDB" id="10318850at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031555173.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33663" checksum="13F3FAE1CA97C741" modified="2020-12-02" version="1">MNIFETCVAYAAYIVQLTSSVRYLFILNVVMNGILALTATLGNGLILVAILRSQNLQTPSYLLITSLSFADLLVGLVYHPLQIVLNVFFLQNNVHGVCKIFKTFNFISILLGLLSFIMAACISIDRYLALRLMHRYRVVVTKKKVGFMILLAWSLGIGLASYSTQTNLFLCYGTVIFSILVVFLLLTCFFYFKAMRALQLYSLQVHAQHPPNYGFDVLKYKKLLKTMFLIFGCLLFCFLPILCSHIARLNLDLSRETILVYFAAHVTLALNSSVNPVIYLIGFKEIRQACKKLILNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL73</accession>
    <name>A0A6P8HL73_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 211-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553365.1">
        <property type="nucleotide sequence ID" value="XM_031697505.1"/>
    </dbReference>
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        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="GeneID" id="116290471"/>
    <dbReference type="KEGG" id="aten:116290471"/>
    <dbReference type="InParanoid" id="A0A6P8HL73"/>
    <dbReference type="OrthoDB" id="5975578at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF16">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553365.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23025" checksum="F086EF319040B767" modified="2020-12-02" version="1">MSAISVLWTVLTVVFTTLCSIAIVSPFWFENVLDPDTFTPDNSSFAAFGLLRYCSKKHIKSVLDMDEWRDFETCSFYGSFQDIPSLFWQFSIIFYGVGLLFCLCSVVLAHVSCCRKTICGSRSVFGVAGVLQAIAVVCLVVSLLLFPFGFGTNFVEKYCGPSGLFYPGHCQISWAYSLAIMSSALFIFCPVIAKHLYVVTPRAKATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMZ1</accession>
    <name>A0A6P8HMZ1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556348.1">
        <property type="nucleotide sequence ID" value="XM_031700488.1"/>
    </dbReference>
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        <property type="interactions" value="1481"/>
    </dbReference>
    <dbReference type="GeneID" id="116293092"/>
    <dbReference type="KEGG" id="aten:116293092"/>
    <dbReference type="InParanoid" id="A0A6P8HMZ1"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556348.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29523" checksum="ABA3EF3F0CDDF2E9" modified="2020-12-02" version="1">MAAENEIGEWFQGIPIVSRYWFCLSIIFPLLGRIGLLNPYYMVLDFGLVVYRFQIWRLITAFVYYPITPQTGFHYLINLYFLYSYSTRLESGLFDGRPADFLFMLLFNAVILIIIGFVATIRLLMDPLVLSVLYVWCQVNKDMIVQFWFGMQFKAMYLPWVLAIFNMVIQGGGMMELIGIFVGHMYFFLMFKYPQDFGGHRFLTTPSFFYKYLPNRQGGVSGFGMAPSSRRPQGDNNGGGGWGRNWGQGRRLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNE1</accession>
    <name>A0A6P8HNE1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat and EF-hand domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557889.1">
        <property type="nucleotide sequence ID" value="XM_031702029.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HNE1">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="116294434"/>
    <dbReference type="KEGG" id="aten:116294434"/>
    <dbReference type="InParanoid" id="A0A6P8HNE1"/>
    <dbReference type="OrthoDB" id="5962529at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052801">
        <property type="entry name" value="Ankyrin-EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24127">
        <property type="entry name" value="ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24127:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557889.1"/>
        </source>
    </evidence>
    <sequence length="784" mass="86078" checksum="D464AF63481AFD4B" modified="2020-12-02" version="1">MPIAIERLEYLQLLKFLQSVRNEDVEQIEKLVANGVPDLINLSEPEHGETGLHIAACKNNEKMISLLLSLGASPNVINFKGQTPAMCAAEFGHTQALLLLTDAGTNLTITDKEGKGIIFNCIQPTKRHLECLKIVIKNGADVNNVSLEGLPLLHVAATEGLDDIVRDLLKAGTDPDGKHKKTGQSALHCAAASGSVGCVRHLLEAGADHDVLDHENVHAAHKAALNGHFEVIRVLAAYGSDLGKVSLDGNTPLHHAATQGYGPICKFLAQRGCPASLKNKEGKTPRLLAKDNEHKEAIKECRKAEKQSARLSKGGGKAGEPYSIRLYDWLQEHEAKVLAMFQQFDPEDDDGNRKGYINKENFVVCLQTLNCPVEVSDLEKIAVVHDPSKEDKVDYGLFISCKKIIGKQFMVTLGKKKKKKGGKKGKKKKGKTKVPLPICTAPDGPRTKHGGPPQDLIERYVHFTDNSRFDRDNPPSHPIQDDSAWYLNFPETSYLNISDAAKLGDLETLKAAFIKGTPVDQRDKYYKTPLMAACSHGNLDMAKFLLDLGADVXGRDNFKWTPLHHACHAGQLDVIKLLXERGAELDAQTINGGTPVMRAIESSKEEAVEFLIAKGAKIQLPNKKGHTALDVAKAYADPRVVAMVQKRWDEIPPPVDKKKRGGSPRKRAAKSAPGQSKTHMPSVKTAPEPKEEMSNTTIHSAIQSTRKSSVLRAASALGIINERPKSIVYSPKRAWVPQPTTEELLRAKEIQRVRFGTDIDFPDYKPPFRKHIITKSEIVAAEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPY2</accession>
    <name>A0A6P8HPY2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC116293808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116293808</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557148.1">
        <property type="nucleotide sequence ID" value="XM_031701288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293808"/>
    <dbReference type="KEGG" id="aten:116293808"/>
    <dbReference type="InParanoid" id="A0A6P8HPY2"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF19">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="913"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1457"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1595"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1668"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="208"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="701"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="1239"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1366"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1366"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557148.1"/>
        </source>
    </evidence>
    <sequence length="1739" mass="197916" checksum="856E1F6B8BC8215F" modified="2020-12-02" version="1">MMKFFDVRENELGSNTAVLRAIKFCAMGTILIHLFSCIWFWLGCDNVGLPNHTCLADGWAMVLNTGIDKIPLWNKYVLSLYWATATATSTGYGDIHAVNNTEKWFSIVAMLVGIALFFGLILGGMASMLTNSDSRRARYSHHLNVIKDYLVDVGIDDTIQDKVMAYYEYLWSTSKGVNGLGIFDDLPLTFQAELSLSINRKVLDKAPLFMGLSPGFKRMLSLVIKPMFFMPNQVIAKKGEIGHHMYYIHKGKAEILNENNDSVLLTLTEGKLFGEVSLVYNLPRSTTVRAASLCVIFTLDRADMNRVIKHYPEVAEKLYTAVEHRCDLMTRTRTDTEISEHDETTWDEPGLKKSSIVTLIRRALNHVIMPDSTFLMIWERVHLVAVLLVCFFYPYVSSFSVSLHALGYGESVTMTIVFALTYLLDVVLLMDFLMRFNLATPATTELKEIRHNYIRTFLFWTDFLSVLPLEIFAFTVAPLHERWHAVTFLRLNRLLKVLRMSAFFSELEDRLEYNIGRIRAVKFAIYITLATHLCACLWFFESCYGESCAHGSWAQHIAKLDVGLDEYIASMYWAAATMSSTGYGDIHAHYVSSQLVAVVVMFFGMMLYGYCLSSIAATLANSASPKVEFLERINAVETFMVNNNLSSELIAQVHRYLTTLWNIHRGEVIPRAKRLMDDMPISLQQDVTAGEAKEVIEKVPIFMETEDSFLRKLSLKTTSYMFNPGDYIVYAGDMGREMYCVRRGLVDVIGDDGVKLATLGPGGFFGEVGLIFGESRLASVLAKTHCQILMLTKDDLDDVLQYFPVVARQLGEAGASNTHLQEIQKAAIQTARTAIRRMSLTVQGNSSSQEAGKLAAIAKKSSQITPIDHCELAILNHIDVEEEIKRPYRELSPLARIFSFFLMRKGIVPTRTWFRVWQATTIFIAGIYMVTLGLQAAVLHVDIPLWILNYIFDVMFLVDIYIKFHVGFYNDNNILVTHPVMTAKNYLRTNFFLDLFCCLPTDIIVLAIWPEQYGVLRILAFARLNRCLHIYKIALFFGFMEGRLGKSENFYRKFKFAVYMGLFTHYVACGWLVISCVGQDDGTHECKSDSWVKNVIHEIGHDAAYHRYMTTFYWAAATTASVGYGDVHAYLTGEMTYSLFCMVIGIVFYGYIIAAVAASLANADAQRARYQERLGAIKNFLEDQNIAEHLRNRVISHYEYIWIRNRGVDPSSLFQGIPLALQADITLSVYKDMIEKVPLFQGTEIGFLKMLSMYIKPVYFLAKEYVVRKGDIGQEMYFIHAGQVEVVSEHERPIVFDTMGGGRFFGEISIVFSCPRTASIRTKTNCDVFVLTKADLDEVLSHYPLIKKKILETAEERQRMVRERAAAFAAKKKEEEDQKKKEEEDRKRREEENKDKESVKDDDGKNTKETKKEEPAETTVVVEDAADEKTSCIKTCFTGSLEXITGLVIMPDSKLRIITFVNCLLIFATSITITYMAAFQDHPWYLLTFDYVCEASFYLEIFFNFHLAFVDNVGDVITDHRSLVMNYVKGKFRFDLVANFPIDIFALAAPAGRKLEILSFLRLLHLLRLVRMEQFFTEYGKKLDIDVFKVRMSKLLFDVILMVHLFACGWYFIDCPDAVCWPEESWIFTQGLETSSAIXLYSTALYWVVATVTSTGYGDVHADNDVEMVYASSVMVIGKLVFGFILGNIASTLANAEIGRVKYEEKLGAIEAHMDDQEIPPTLQHRVKNFYQFIWNTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR87</accession>
    <name>A0A6P8HR87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 23 member 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555150.1">
        <property type="nucleotide sequence ID" value="XM_031699290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR87"/>
    <dbReference type="FunCoup" id="A0A6P8HR87">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="GeneID" id="116292051"/>
    <dbReference type="KEGG" id="aten:116292051"/>
    <dbReference type="InParanoid" id="A0A6P8HR87"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031555150.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="68284" checksum="7FBDE0CE0219E054" modified="2020-12-02" version="1">MADNLKAEKIRSKGEKDDEKKKKKKKKRMGGLSYLINENPPWYICILLGFQHYLTMLGANLAVPFALSEKMCFANNHLAISEVMSTVFFTSGVSTILQTTFGVRLPIVQGSTFTFLAPAVAILRQPKFLCPVYNSTENSTMGYDKDVWKPRMLEIQGAIMVSSLFQVLVGFSGLMGFLMHFIGPVSIAPTIILIGLSLFEVAAGKAGTHWGISMTTIVLIVIFSQYMQGINLRIPAYSRDRGCYVAKYPLFRLFPIILAICTSWLIALIVTAAGGFPDDPELPQYMARTDARIKVLREAEWFRVPYPGQWGLPTVSAAAVLGMLSGVVASIVESIGDYYACARMSGAPPPPTHAINRGIGMEGIGCIITGAWGTGSGTTSYSENIGAIGITKVGSLRVIQVAGCVAIVMGVVGKIGALFTSIPDPVVGGVFMVMFGMITAVGMSNLQYVDMTAARNMFIVGVSVVFGMALPFYLKTHENAIQTGYEEVDQIITILLSTNIAVGGMLALFLDNTIPGTKEERGLIAWKHHLIPDEDEDDDYEVATIHVYDLPFCLKRLGYNEISRYIPFLPYYHPVSHDGACHVAAATNVAMETGESTKRDLALEEGKNSYAVQPNTITEDPEDTTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRC6</accession>
    <name>A0A6P8HRC6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Guanine nucleotide exchange factor DBS-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116292087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MCF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555185.1">
        <property type="nucleotide sequence ID" value="XM_031699325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRC6"/>
    <dbReference type="FunCoup" id="A0A6P8HRC6">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="GeneID" id="116292087"/>
    <dbReference type="KEGG" id="aten:116292087"/>
    <dbReference type="InParanoid" id="A0A6P8HRC6"/>
    <dbReference type="OrthoDB" id="10004999at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF211">
        <property type="entry name" value="LD43457P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="12">
        <location>
            <begin position="616"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="807"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="964"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="973"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031555185.1"/>
        </source>
    </evidence>
    <sequence length="1070" mass="122395" checksum="C7124A4379EDC182" modified="2020-12-02" version="1">MANKNQGTEEEPSQEPKIRAYDIAEILQENYAFLSGGKDHYNNLIVTIPVDSKINIADDNYIKIVFKYLLDLSSRFFDYEECVKQEFTVILDRRKGRWSNVNTTLAKLKNTFPSPISCVFVLKPQGIIQKFMGGSASQEAQATFKIVVLGSVADLQTYIEQDQLSTDLGGKLEYKHEEWIENRSAIERFYCKVEEISKKLDMMRRKFERTEITSSIQEMEFTLESQKELWKDIKEDIISTRMTGVTLLKCIHPSRNKDDENDNAVGPDVKANTTELEGLFKKLNDSDKEFERFFENHEMKFRQGLEISLFELEVGQITGLLFAATSKVSTMVDVGDSRMAAEKLLDELHTFKTTTSRDPISRAKALIEKGKELAEKDSLSKRTVKMRCDELSQSCAELNNKIEMREKQLKNAMDIHDCLQQVSGWCTKGSDLLATQPVEKFQTSEGAEKCLEEIESFLKDRQGISLKKLNQLEKMSKELGNTFLINKVKDSLKRIGQVNEMMTKRENSLKRMVAKRPVQPVTALQVDKGEPKRKSSSPSNAPKSAESKRKMSSASAGEARKVKPSPTPKRPVSIVVSNNSDPPSPVPLAKNYAKAVSIPDLLDAVDGEDTTEIIKKRMQIMMELVATERDYVEDLRCIIRGYIREFEKASDKIPPNLYDKKNIIFGNVEQIYEFHNEEFLKELEKCVDDPLLVGEVFHEKRDDFDMYAVYCKNKPASEALQQDFVNLPIVKEWQNKLGHKLPLSAYLLKPVQRITKYQLLLKEMMKNTRNNRDAYVSLMEALQSMQSVLRHLNDVMHSRGLRGYHGNLAELGKLLLQDSFNVWHVNKRGILPLRGRPRQVFLYEKMVIFSKREEDFSRKDVVCYQYKNSLKLSETGITETVKHAPMKFELWLNNRSEVFILQAVSQEEKEKWVAKLRDVLLSQFDQAKAEQKFKSQELGKWNSTPTLGQENQNNLHSKTLSVTSLDQESGNTYDDDGFDSDEFDSDESPDECTSLGSSVQPLGQLMQHGFKYTALAEYYAIESGEMTVKPGQAIEVLKIGNDGWWYARDIASQQQGWVPASYLEPLVPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRG3</accession>
    <name>A0A6P8HRG3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-binding cassette sub-family A member 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294278</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cholesterol(in) + ATP + H2O = cholesterol(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:39052"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557698.1">
        <property type="nucleotide sequence ID" value="XM_031701838.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HRG3">
        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116294278"/>
    <dbReference type="InParanoid" id="A0A6P8HRG3"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000327">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000465">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1187"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1301"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="515"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1379"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="15">
        <location>
            <position position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557698.1"/>
        </source>
    </evidence>
    <sequence length="1699" mass="190794" checksum="32EF92F2D1C136AF" modified="2020-12-02" version="1">MGQSRQFCLLFWKNWALAKRSPVRTFFEIAVPLFFILILVILRAFVIKNEQEPPIKYKQFTVNQLPEGLIGENFNLAYGPNTTDVNEVMSKVDFKTLGFNKSKGFGNENEMVDFLLEDNDIASEFLGGVYFESTPEQNNVVYKLRLNSRARNSKTKIKAFGSDPSNSWNTQLTFNSFQIPGPRNKNATHGGPPDYYDEGFLALQNAIDMAILRYRDKNSSAQSIAIKMQRFPYPAYIKDSFILVIQQTLPLFLILSLVFTALCIVRDIVHEKERKLKESMKMMGLAGWMHWLAWFAKYLLILLVAVVFASVLFTIKFSSNGKVLNQSSPTLIFVFLLLYSISSIMFCFLVSVFFSKANVAAVAGGFLWFLSYTPYNFIAQSYDTMSLGLKIASCLLSNCCMSIGSLLIGKFEGRGTGVQWSNIYEGVSVDDDMTLGYVLLMYIADILLYGIITWYIEAVFPGEYGTPQPWYFPCTSRYWCGVNKQLDAESNGVVSNGVVSSEFLEKDPSGLHAGIKVQNIKKSFSTEKGEKVAVDGVNLNMYQGQITALLGHNGAGKTTLMSMLTGLFSPTSGTALVNDCNIIDNMAGARSSLGLCPQHDVLFDRLTVEEHLWFFAMLKGCPRRRVQSEIDKMIDSVGLSDKRHVQTRALSGGMKRKLSVGIALISGSKVVMLDEPTSGMDPSARRFTWDLLQQQRQDRTILLTTHFMDEADFLGDRIAIMAEGQIKCCGSSLFLKNKYGVGYHMAIVKATLCDVPLVNAIVQKYVPTAQLESNIGAELTFILPSEATGNFEPLFTELESRRQELGINSFGVSVTTMEEVFLKVGEEMDDSLTKALQNEETDTINNGADDDDDNDFRIEVDDTNTMGVISEGSCQVNAEHNCNMQLGFQRWYAMFIKRFLHSKRNRLSIIPQLLLPLIFTLFALISAKTFPQPGDAPPLALNTTSFGKNFVPFSFVPNNRTKILAKEFKDQFKGTDTKAIRVNGDMSHYLLKEPDDVGQGDFNLRYLVAASFTNKTQETEITAWFNNQPLHAVAITLATVHNGLIKAISGENSSLTTINHPLPRTTKDTIDDLKRNGLGFLISFNVLFGMAFLASSFVVFLVQERSNKAKHVQFVSGIDPLSYWTSAYVWDLINYLVPALSLLILLAAFDVPAYNGPNLGYTFLLLMIYGWAIIPLMYLFSFVFTTAVYAFVVLTIFNIVTGLATLMTVFILEIPGVGERDAANVLKWVFLILPNYCLGQGLGDIFNNYNTLSVFNQAMRECKEMFPYLTIDECKKLIKEKAGDYPIEFQENYLSWENPGIGRYLVFMAWEGIFFFLLVLLFESGLPRRFYLSLRSSFSMSLKVMRPGDIYSSSVVEDDDDVFAEKRRVAVGSDNQDVLVIRELSKVYPGRRGRGPLIAVNDLSLGVPLGECFGLLGVNGAGKTTTFRMLTGDEMMTSGTAVVDHFDIRSNMEQVRQRVFFCPQFDALIGHMTTREMLYMYARLRGVPEIDIPHTVENLMRSLLLSNHADKLTKSLSGGNKRKLSTAISLVGNPPVVFLDEPTTGMDPVAKRLLWNALCRVRADGRCIIITSHSMEECDALCTRLAIMVNGRFKCLGSPQHLKTKFGEGYTLILKIANPDQLPRLKEYIEEVFPRSILKDEHLGMVHYHITDMSISWAKIFGEIERIKLDYDIEDYTISQTSLEQVFLNFARGQRLEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRG6</accession>
    <name>A0A6P8HRG6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Amiloride-sensitive sodium channel subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294653</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558156.1">
        <property type="nucleotide sequence ID" value="XM_031702296.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HRG6">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="GeneID" id="116294653"/>
    <dbReference type="KEGG" id="aten:116294653"/>
    <dbReference type="InParanoid" id="A0A6P8HRG6"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="63"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031558156.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="63292" checksum="8F0669D3B2E757C6" modified="2020-12-02" version="1">MPTFLHLRGDWFRSLAIVYETDFDETATPSSSNRKRRSXEDKICFNYLYCKWKYAALEMNQSTTTTTQTPTTTTTPLTTTTTVPTTAAKAKPTTAKASPTTNQTTTSAATTPTAKVLTKEEKEEAAFSGTLSQPDPSTLTKESRDTEELSVNLASQPEDLMRETGHQFSDMILSCTYRGISCTNYTEKLWSHFWHYKYGNCFVFNSGKDSFGNFKPTLRSNKPGPTNGLIIELNTEQHEYLGQLTQEAGIRVVVSKQGEMSSPLEKGFSISPGYSTSAGIRQVHIIREDPFKNKSCRHSEDIESNNIYRNRYNISYSSTVCKDSCLAYRQLETCGCMEYRFPNKGQRVCDVLNLTVISCLNELQMLYQENKLGCSEKCGPPCIEDIFKLTISSSRWPSDNYKSKFLTKLQEDRGVYLDPDADPRAYFVRFQIFFEELXYEVIEEYLAYEVINFISDIGGQLGLWIGISCLTATEFLELLILIIVRISCEIMNWMNIVGNAXISTAEHKRCEREDRAGTRXVREDIYETHFSVPDANSDSYHSLTIQEYDSKIINTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRJ9</accession>
    <name>A0A6P8HRJ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neural cell adhesion molecule 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555312.1">
        <property type="nucleotide sequence ID" value="XM_031699452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRJ9"/>
    <dbReference type="GeneID" id="116292188"/>
    <dbReference type="KEGG" id="aten:116292188"/>
    <dbReference type="InParanoid" id="A0A6P8HRJ9"/>
    <dbReference type="OrthoDB" id="5988073at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028139500" evidence="3">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555312.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23854" checksum="7FC241269B45B2D8" modified="2020-12-02" version="1">MNSFPLTFRLIFTVICFLSCVNLSDGFKWISLPSQRTKGHVGSTVHIKWYYECNNFGISKILYNNTEMFYRYGNKQNYSTIKNAVPHFSVIGGSNTTIIISHVHKNKSGSYCCVVDCGGGDKDVQCTFLFIYVLPRIKYLSPNLYGKQGDSITIRCNASGNPAPRVTGIHKDTNTTIANSSVMSFNITGKASGGKYCCHVSNGFGEETNCTSVEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRV0</accession>
    <name>A0A6P8HRV0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyadenylate-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558236.1">
        <property type="nucleotide sequence ID" value="XM_031702376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRV0"/>
    <dbReference type="GeneID" id="116294729"/>
    <dbReference type="KEGG" id="aten:116294729"/>
    <dbReference type="InParanoid" id="A0A6P8HRV0"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="68"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="145"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="235"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="319"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558236.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46551" checksum="9BB8C90FD2DECF9D" modified="2020-12-02" version="1">MALCLRLLRSGIRKSLSVLTYQGSKNSTLYTTWPRATQLTASWNIRFLSSLQNQIELTPEKELEKNRRTIFVGGFEAGTTEDILRQYFASFGEVQSVRIVKTFLGYSRNYGFVCFKDPEVADEVLEKKHVILDRDIDVRRAKKYRVVYVGGLPSHFTEKTIRDHFLQFGNVESVQFIDNAKIKSKSGFAFITFNDVNDAKKALEQEKQEIEGYEVKVKPRDASDRDVEAEVSDSKKLKVEGLPFETTVEQLRDHFEQFGQLKAINLLINSKRKMCVGILLFESLEGVENALSNEYHEIEECPVNVARVPDSVNFGTREKAIFIENLASQTTESTILNYFRRFGQIAKVHLVRNPSTGISEGCGVVKFRRPIPAEQFKNISTHLIDGTPVQVRRRGLKLRPALALNEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS28</accession>
    <name>A0A6P8HS28_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotrophin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558281.1">
        <property type="nucleotide sequence ID" value="XM_031702421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HS28"/>
    <dbReference type="GeneID" id="116294760"/>
    <dbReference type="KEGG" id="aten:116294760"/>
    <dbReference type="InParanoid" id="A0A6P8HS28"/>
    <dbReference type="OrthoDB" id="5946465at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558281.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14836" checksum="1FAFB28C86D2E695" modified="2020-12-02" version="1">MSSHHYRFAEHENFCSAIKSGFLPTIIEHLKKPGSEVNMTVDAGRNALHLAAEAKRENIIRYLLQNGANPVAEDDTGATPLLIAIWSGDKDCVKTLLDFGADPTARSPDDESYVDCAEEFPEIQAMIKKAIKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTH4</accession>
    <name>A0A6P8HTH4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116295878</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559694.1">
        <property type="nucleotide sequence ID" value="XM_031703834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTH4"/>
    <dbReference type="GeneID" id="116295878"/>
    <dbReference type="KEGG" id="aten:116295878"/>
    <dbReference type="InParanoid" id="A0A6P8HTH4"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028088395" description="Reticulocalbin-3" evidence="13">
        <location>
            <begin position="28"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031559694.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46213" checksum="C510FA456D6B509C" modified="2020-12-02" version="1">MPRSYLYLENMIKIFLLVSCFRVLVGAIESTPFGDVDESSDFADEDSEIYEDEPIDHSAFLQIDNTADLHIPKQTKRMRNRIRVMLKEMDSNHDGKVSEKELSDWIEKVMTEYLTSEGQKQMPKIDKDNDGLASWAEYAAAAGYTQGDAPEPRQSSEKSKKRDKEKFDLADTNKDDKLSYYELGVMIHPNEAPQMSRIVVTEFLEVMDRDRDGQLSFNEFTGEDPSLPTINEDAKKQLKKVFKGLDFDQDGKLNNEELIDWLLPNNKLPHQSEAENMMRDIDDDEDGALTAEEIFKHYNKFATSRATRYGRMLKDEVPPEDDEALLKKTKKGEKQNEKAKEEKKDGKADERRKEDGESKTKQDESQSEKAKGEKKKNDGEDKIKDGKKDSNKNGRQKPVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU68</accession>
    <name>A0A6P8HU68_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293012</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556255.1">
        <property type="nucleotide sequence ID" value="XM_031700395.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293012"/>
    <dbReference type="KEGG" id="aten:116293012"/>
    <dbReference type="InParanoid" id="A0A6P8HU68"/>
    <dbReference type="OrthoDB" id="189619at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052169">
        <property type="entry name" value="CW_Biosynth-Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33393">
        <property type="entry name" value="POLYGLUTAMINE SYNTHESIS ACCESSORY PROTEIN RV0574C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33393:SF11">
        <property type="entry name" value="POLYGLUTAMINE SYNTHESIS ACCESSORY PROTEIN RV0574C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Capsule synthesis protein CapA" evidence="2">
        <location>
            <begin position="41"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556255.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45365" checksum="5A1E7D53C31860C0" modified="2020-12-02" version="1">MVFTKIVRIFQYLYARASLTSHPYYNINRQFISSMSQSSVTLFVVGDVMLGRGIDMILPHHNDPVLYESNGLDAYDYVYLAEKQNGPIPPASERGVSYIWGDAIQILEDKKPDIRIINLETSVTTCSSPWPMKGINYRMHPGNIDVIKAAKIDCCILANNHVADWGFEGLNSTLTTLKDGGIKXAGAGRDQEEVESPAIFEVPGKGRVIVFAAGHHSSGVPDSWHASSTHGGVNIIEIYKPKKAVSELHQLVKKYKQQNDIVVLSIHWGGNWGFDIDPAFKKFAYAAIDNADIDLIYGHSSHHVKGLEVYHNKLIIYGCGDFLDDYEGITGYEHFRDDLALMYFVEINPATGKLGGLKMVPTQTKHLRVNNAPEEGIEWLHETMKRECKKLGSLVERNGNELHLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVJ8</accession>
    <name>A0A6P8HVJ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Dopamine receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17 18" type="primary">LOC116295648</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559389.1">
        <property type="nucleotide sequence ID" value="XM_031703529.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559390.1">
        <property type="nucleotide sequence ID" value="XM_031703530.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559391.1">
        <property type="nucleotide sequence ID" value="XM_031703531.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559392.1">
        <property type="nucleotide sequence ID" value="XM_031703532.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559393.1">
        <property type="nucleotide sequence ID" value="XM_031703533.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559396.1">
        <property type="nucleotide sequence ID" value="XM_031703536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVJ8"/>
    <dbReference type="GeneID" id="116295648"/>
    <dbReference type="KEGG" id="aten:116295648"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="401"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031559389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031559391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031559392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031559393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031559396.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="56303" checksum="0F3F3AEBB5CD71C4" modified="2020-12-02" version="1">MANLTDSNSTWINNSTKSDSPGNSVGLAIALSLANIISITVGSWGNLLVVIVVVCNRGLHSSTNFFIASLACADLLITAICMPVFYVYNVLTWPVWHFGSAVCKISSYLVHTSVMASALSLLAISYDRFVSICFPMKTIMTIKRAKLLVAAIWFVSPILLFASLLHHDVVPMKYKGQDAFMCVETWDTKQELHRYQMYRISCYFLFLLQISVLYLVIGCRLYKREPPGAQTMQGKAKLNNEKKKIIKMLFSVVLLFALSWLLYIINKLLNIFPPSKNYEAPDVFVFVGNFLGLLNSVINPIVYAALNRNFRTAFKHAIRCNCKYEAEERRRTQSVVSLRNTQQTRDRKCSESYVSRRASESTSFEFRKNSVINGFDLVTDVQDDRQPRCLTIDNSEVNIANERNRKPSVPEKQNYTAKRKVSFGPEIMDLPDAASSDHNDENDDITNRRHSRSRGNSITSYRLHSTSTNGLDPIEESFHQNEDESKDNKGFEYSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVV4</accession>
    <name>A0A6P8HVV4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116295738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031559506.1">
        <property type="nucleotide sequence ID" value="XM_031703646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVV4"/>
    <dbReference type="FunCoup" id="A0A6P8HVV4">
        <property type="interactions" value="1712"/>
    </dbReference>
    <dbReference type="GeneID" id="116295738"/>
    <dbReference type="KEGG" id="aten:116295738"/>
    <dbReference type="InParanoid" id="A0A6P8HVV4"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="128"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559506.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="43068" checksum="98D9DF0FD5C09736" modified="2020-12-02" version="1">MLKKGILLFRVGLFTVRSLAYNKANSRAIVLDAAFKPVFWVVDKLVSVLGPAFVLLVVGLISTVVIIYYTSILPTILEEHILWIVIHIVVAHWLLLNISFHYFKSVFTSPGHPPKEEKLPGNVRDFLICRICLHPKPQRTHHCSICKKCILKMDHHCPWINNCVGHFNHRYFILFCIYMCLGSFYVAVCSWELFMEHFFDDKKTEKDKSTETQMQEKIAVMFGRYRSYSDFEHNSIIFVFMLCSAVSLALGFLTAWHVLLIVKGETSIELHINKSNRIAFRKKGYVYTNPYDYGRWENWKLLLGIVNGRYEARNDCQSNYNGLLKKYNFNSRSWASVLWPSSHHPYGDGLTWKPPQKSFKISGRRNFLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWZ0</accession>
    <name>A0A6P8HWZ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293771</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557097.1">
        <property type="nucleotide sequence ID" value="XM_031701237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293771"/>
    <dbReference type="KEGG" id="aten:116293771"/>
    <dbReference type="InParanoid" id="A0A6P8HWZ0"/>
    <dbReference type="OrthoDB" id="5976775at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557097.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25061" checksum="3CC949D9DDB750B2" modified="2020-12-02" version="1">MVHEVLAFPTLSKGSVLQIHCLAFIGLQLRDAASIYSRVELDRSQVDDLKTLCQHYFNTYSQLLAKVNPTIWTIGYAIPQHTNQLFDELGYGLGLNSMQGREAKHIQLAKYTENTCNVQKHLRWWIVFRHEFVCQIWLREMNXFSTTYEENRTESFIPKKVQESDKAMCYCGMPKEAADEGCRICTSDLLIAIKGTAVSGKISPQIKTFVDLPPLANGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY35</accession>
    <name>A0A6P8HY35_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurogenic locus notch homolog protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116294177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557585.1">
        <property type="nucleotide sequence ID" value="XM_031701725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HY35"/>
    <dbReference type="GeneID" id="116294177"/>
    <dbReference type="KEGG" id="aten:116294177"/>
    <dbReference type="InParanoid" id="A0A6P8HY35"/>
    <dbReference type="OrthoDB" id="5971814at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557585.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15607" checksum="2ED335D8A996F418" modified="2020-12-02" version="1">MLTETESLCRIMCYNTDTCVSYNYKKDSTACDLNDSDHIQHPQDFVKQSGYVYVGTENACQNSPCHKNSACRTNIRDETKPHWCVCPPGFRGPSCSKGIDECQTSSSSKCPEFSTCQNTNGSFHCQCNVGYKLNDSKCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYS2</accession>
    <name>A0A6P8HYS2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease P protein subunit p14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561534.1">
        <property type="nucleotide sequence ID" value="XM_031705674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYS2"/>
    <dbReference type="FunCoup" id="A0A6P8HYS2">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="GeneID" id="116297452"/>
    <dbReference type="KEGG" id="aten:116297452"/>
    <dbReference type="InParanoid" id="A0A6P8HYS2"/>
    <dbReference type="OrthoDB" id="2262258at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561534.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14723" checksum="E35A1A064DDEC3DB" modified="2020-12-02" version="1">MERVTFKQKAEYFYLKVLLEFERCDGVNVPEIDMLLYKRLLIQALEELHGQVGAALTVDVLKYNSSTLQAILRVPESGLVKVWSALTLFGFYQDQRCAFRVLQVSPHLMAFAVDSRQWHPENEMIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZA9</accession>
    <name>A0A6P8HZA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21 22">Sodium/potassium/calcium exchanger 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">LOC116296795</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21 22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560743.1">
        <property type="nucleotide sequence ID" value="XM_031704883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560744.1">
        <property type="nucleotide sequence ID" value="XM_031704884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZA9"/>
    <dbReference type="GeneID" id="116296795"/>
    <dbReference type="KEGG" id="aten:116296795"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000004">
        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="19">
        <location>
            <begin position="98"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="19">
        <location>
            <begin position="513"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="352"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031560743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031560744.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="75742" checksum="A605B15A8A956B3B" modified="2020-12-02" version="1">MRILTCRKLNRVYRTERRKVSSYIVPMVSLVVCVILGILVCYLDISTMTSEKNSLTYQGIFHHRSLLNASEPTESPGEYPEDMFTLEQRRKGAVILHIIGMCYMFLAIALACDEFFVPSLVVIIERLQISEDVAGATFMAAGGSAPELFTSFFGTFADPNSNVGIGTIVGSAVFNVLFVIGMCAMFSKGVLELTWWPLFRDCMFYSFSLLLLIIFFIGDWIQWWESLLLLSFFVFYAIFMKYNRTIERIVKNFLRSNKVSKVDVRDPGLANPGVHRTEHYLEKAIEYLGSNAKQNAERPCFHYGAFQLVVNSMDPLWDASIAVRVKHIKQMSMTADEAPEKQQDQELKYSTVDLQKKPSSSGSQHLTENGTTQTDVDFPDGMKMSNEEDHSNGNIPDRDLGNGSCVNEQDFSSSYHVVCIDSTIPGMCADNNNKRRASDSSKVSQNAVTTKMSEEESVVEEADSIDDFDDKPIDLSWPEGWKERLVYIIKAPIMFPLYFSMFDVRKPEKSKFYPWTFIVSIFWIGIFSYLTLWWAVVVGDTFGIHSVIMGLTVLAGGTSIPDLITSVLVARKGFGDMAVSSSIGSNLFDITVGLPLPWLLYSAVNLGKSVNVSSDGLLCSIVLLFGMLIAVVLSIAILKWRMSKLLGAAMFLLYIVFIIMSLLLEYKIIPCIKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I249</accession>
    <name>A0A6P8I249_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Upstream stimulatory factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116295323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558967.1">
        <property type="nucleotide sequence ID" value="XM_031703107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I249"/>
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    </dbReference>
    <dbReference type="GeneID" id="116295323"/>
    <dbReference type="KEGG" id="aten:116295323"/>
    <dbReference type="InParanoid" id="A0A6P8I249"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11396">
        <property type="entry name" value="bHLHzip_USF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
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    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
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    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="271"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558967.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="41734" checksum="761F9998F419C280" modified="2020-12-02" version="1">MTSLFDPMTSASHSNSPTLDMLDGSLDTEKTSLHEAKGSDPTQVSPEPETVTVTVSTVGDEHGLVGHRSNSPFVADPNAIQFQYRADNNGQVQGTGFDGGSQQIRVVHVQSAEVVGERVDGSGTPTNFVSQPQVQTVIQSPYSNGSSPTHQSDTDATPDANRFTYFHTQPDGAGGGNVVQTGAGDSLESNNTYAVRSIPVSLQQPSSPSQLPGTITMAEAQTITTVGTAAGGFYVMMSPQEVMQSSTQRTIAPRTHQMGSKVEGTRGRDDKRRETHNEVERRRRDKINGWITKLAKVVPDCACDQTKAGQSKGGILAKTVDYINELKTANTRMGESLKDNEQTAIDIELLRQQNEELRQENAILRAQLQQHGIDLGTIVSVGQPSQGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I338</accession>
    <name>A0A6P8I338_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand calcium-binding domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562959.1">
        <property type="nucleotide sequence ID" value="XM_031707099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298585"/>
    <dbReference type="KEGG" id="aten:116298585"/>
    <dbReference type="InParanoid" id="A0A6P8I338"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF7">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="838"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="917"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562959.1"/>
        </source>
    </evidence>
    <sequence length="984" mass="112378" checksum="AA0875052C599E74" modified="2020-12-02" version="1">MKSCNQGKTPDGPCYSVATTMGKEMSVKAGKTNNGLPRLPTLPVIEHPSSKHVKGDLEVHGSSSSQNENTAKNKGPLPPLRNEDSRYSREKGRRHSRGATWPADLGNGRGIRPLTHKKTVDELEELIYDKLASGFYGVRQAFKSNDXQGKGNISSTNENGTNVEKNGIVQKEWVDPIVRPTSMQVNSLPANKLRITQREAQSKKEGEMTAKQGKKIAPKYYTALQVFPMMKRKANENFIEFAKLLPSSCFEEESMVLKPQLRYALYSMNIHMYDDEYDKVWDRVDRSGMGAVATHLFFKSLGLHTRHHSTEKKTTDYHVPVXIEEEPEEPQEPQAIQQHEEQHEKQLSKTDEVKEDDHKTRTAESGLSETNVVNGDLLKVLEVKFRHGYNSILDXFAKYDTQSTGMVSRGEFRRVLSMCRLNLGPVEVELFLSRFGVREQKMVPYRKILDAFEDRTEKGLLQKILEDSKHRFNRSRESDIGNTTAVDAEAKLLDILHADFLALLAAFKQLDRENLGLIKKYQFQEMLDARFGVKLTKDQISEMLKKIGAETADGLVLYGRFLEEFSALRDHNMHADVQDRPPTTNSMRPSTCPTRPLSVQSVRSHVGVDRSTSFADIKKSTPXSRDVDQLMAEMGHLLTDKFQVINKTFIGIDKVSRNCGNLTRETFRKLFQRHSLRLSPSEVDNLWKKLPIERDGTMNFIELVKTCFTAAGKTPPGDHDDYQTKGLSRALQNFARAHVRKTLENFQEEEEENQYNDIPYEACVTSSLDKTEEPHXNDVRPKEGERPKFDVIMARIKNEVRENFNQVKDGFHAARNQDQNTINTDLFTEILLKHCNSLSGLECDVLVQRFDRDKTGRVRYKDFLNVFLPTMPEGTDPIASPWQPNHGRAKTYPERRRVSSNEALHSIMNQIRNKMILDWKALRRAMKKSDXNGDGMITVSDFKTVMKAFGFSLDEEDFYHIFSAFDVNMDGRISYVAFMKEALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3Q4</accession>
    <name>A0A6P8I3Q4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Prostaglandin E2 receptor EP4 subtype-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559420.1">
        <property type="nucleotide sequence ID" value="XM_031703560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3Q4"/>
    <dbReference type="GeneID" id="116295664"/>
    <dbReference type="KEGG" id="aten:116295664"/>
    <dbReference type="InParanoid" id="A0A6P8I3Q4"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF16">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="33"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559420.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43934" checksum="BD2AE74039D07F79" modified="2020-12-02" version="1">MNHREFGQEAFNNDQFLAGGITLFISGFIGFIGNTFVLIITYRILRYRKNIPSILILFLAWTDFLTFPLIYPQSLIKYFFGVYIGDYSACDFQGTVITFLYGVSILLVLIMSIDRLLALYKPFCYEQHISYDKEKVKVTAIGVSAAGFTIALLPTFGVGRNVLHFPGTFCLFEWGAKTVDGIALLYIYMTLLSIAILAIVFCNFTVVLLAWRLMRRLHSESTLGDKETASTCQTKKKHSNRGDMEMQFAKLSCMTAIAIVGCWSLFLIRLTMIQAGYPFDAFIDFTAVRLASLHSVVNPWFYPLLRRKYREGFWYLITWIGHVVTCTLIKRPTNTLDDIVGGTPRTKRSKKMQKVDERRRSSSQRFLSTTTLSASVTTDSKSTDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3U1</accession>
    <name>A0A6P8I3U1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116298810</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563234.1">
        <property type="nucleotide sequence ID" value="XM_031707374.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298810"/>
    <dbReference type="KEGG" id="aten:116298810"/>
    <dbReference type="InParanoid" id="A0A6P8I3U1"/>
    <dbReference type="OrthoDB" id="5982361at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33776">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33776:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031563234.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="45082" checksum="3CC559C8ACEBB383" modified="2020-12-02" version="1">MEEYLKPLIREGPNELIXHVGTNNICDDNPREVAEDVSGNSESIYNPISNVRGFKMALLNIVSLPKHIDEIRISELFKSFQLFAFNETRLDPSISDGEVRICGYDLIRKDRSRKGGGVCIYLRSSINYKIRPNSRPFIVASVYRPPDCSNNFFTEFESMIRAVDNENKELHILGDLNCDMLKRIPNQPTRILKSIYEIYQLRQTIEESTRITNTSSTLIDHHTTNSIEKLALSGVIHMGISDHSLIYAIRKINPVTKTEGNVKIIEFRNMKRFDQQQFIADLLGQPWELIVLENNINSMWSRWKEMFLEILNKHAPIQHKRSRSFNVPWLSRQIKELIYTRDKLKRRAIVTKQEEDWTAYKSFRNKVNIDMQQAKTNYYLEIILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I411</accession>
    <name>A0A6P8I411_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable glycosyltransferase STELLO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563304.1">
        <property type="nucleotide sequence ID" value="XM_031707444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298869"/>
    <dbReference type="KEGG" id="aten:116298869"/>
    <dbReference type="InParanoid" id="A0A6P8I411"/>
    <dbReference type="OrthoDB" id="5945766at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005049">
        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031563304.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41859" checksum="E8A74771B179E963" modified="2020-12-02" version="1">MSVKLILRFALLVLTLTGSFLAAWLSFSILQLSHTKREGVSNFATPSCLRDSFSDVVLVIIYNHPLYTSVPLLKKLYGNAFPXIMFCGPKPENNSLEHPIEAVYHKKGYFGYLCLARAMEKYSREVQIDIKDEPMFHSLSANSKSSLVNYNGYLVINDDVMLNFWNFLRFDXRKIWEGPKAPVQYPGFVPRRKWYWWKSRWGKSQCQKAYNEIWSLQKDFNMWDRLNVTKTMEILTKNGRGKTFCYRGRSDILYVPARFSEIFQLLAHIFYKHSVFLEIAVPTMLRMIDLEANFEQIPGVYLPGRVNESFVKDSRFFWQVYNKREYFVHPMKLNYANSEMSRALLKTWVIEYIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I457</accession>
    <name>A0A6P8I457_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559707.1">
        <property type="nucleotide sequence ID" value="XM_031703847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I457"/>
    <dbReference type="FunCoup" id="A0A6P8I457">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="GeneID" id="116295889"/>
    <dbReference type="KEGG" id="aten:116295889"/>
    <dbReference type="InParanoid" id="A0A6P8I457"/>
    <dbReference type="OrthoDB" id="5953442at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17491">
        <property type="entry name" value="MFS_MFSD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000206">
        <property type="entry name" value="Major facilitator superfamily domain containing 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000431">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559707.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="57473" checksum="A9FB996EB290CD2F" modified="2020-12-02" version="1">MEGSSLVSEKLSFRVKFCYGVGHILNDLCASMWFTYLLLFLHKVVKFSNTMAGTLLLIGQVVDAISTPLVGIESDRTGNCKYGRRKIWHLVGVVCVALSFPFIFNLCVSCASSSPSIAALFIYYTPFVMIFQFGWAATQISHLALIPELTNDEQEKCSLNAIRYGFTVVSNILTFCVVWIFLRSMASDSTKVSNGDSEAFMYVVIVLLFVGLLFMLIFHVGIREPFRNCSHEMASSGNMRSSSSWKMWFKKVQFYQVALLYMSTRLVVNLSQVYLPIYVTETLQLHKEFIAVMPLVVYTSGFIATFFAKPFNQFLGRKVTFSIGLVVVIGVCISFFFLNNTVHHVQMYMYAASIGLGIGGSTMLITVLAIIADLIGDNKETGAFVYGAMSFVDKLSNGIAVQVIQIEHPCAGSAVCCGGCSKYYKIIMSYVVGGAAVLALLSLLTLFKTKIGHFEKEKKMKTCAAQRRLLHNDPSISTTVSRSNGPSKNGPLIPYEPQGHPKYGAIECQKSSPNSSIQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6V9</accession>
    <name>A0A6P8I6V9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116299717</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564294.1">
        <property type="nucleotide sequence ID" value="XM_031708434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299717"/>
    <dbReference type="KEGG" id="aten:116299717"/>
    <dbReference type="InParanoid" id="A0A6P8I6V9"/>
    <dbReference type="OrthoDB" id="5991872at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564294.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33972" checksum="3920C8A8DC1C6525" modified="2020-12-02" version="1">MANVPRIHFPNLMDFVGWHGTFVLVTIVIFDLLLSSVGAGDGSCPCTGGVAYGTAMLGLPAVSIFLVAFFSYFYQHDTQSPWKDLKAYFKSKQPCSYPPRSRNWEXHSGVFHQCTECQGRXYKIKITISFFVSFVYPMLWLALGFRKSTYYACARVGPNPHGILYYCDNLSPPDSYEKNYTLAISKSLLVGNVLLVVVIVLASALFITYRVIKSKILESDDVQIEDNYDQERPPQAPINNFGHSNEGVVIPGSHDQMSSPITRSTEGPSPASGMGYEGFRERTGDMSRGRASSRDVHEPLIKVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7G4</accession>
    <name>A0A6P8I7G4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">LWamide neuropeptides isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116296704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560625.1">
        <property type="nucleotide sequence ID" value="XM_031704765.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560626.1">
        <property type="nucleotide sequence ID" value="XM_031704766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7G4"/>
    <dbReference type="GeneID" id="116296704"/>
    <dbReference type="KEGG" id="aten:116296704"/>
    <dbReference type="OrthoDB" id="5983162at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF3">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653152" evidence="3">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031560626.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31976" checksum="4B44C1E6BD9161EF" modified="2020-12-02" version="1">MAFKCQLVLLAITFLLAQCSGSLDKKDSTTNHLDEKKTDSTEAHIAQETEIVKQNSDIGSVEDNSKTEEKKRSAAPQQPGLWGKRQKPGLWGRSADAQQHGLWGKRQKPGLWGRSADAQQHGLWGKRQNPGLWGRSAEPGQPGLWGKRQKPGLWGRSAEPLQPGLWGKRQIPGLWGGKRQNPGLWGRSADPGQPGLWSKRQNPGLWGRSADAQQPGLWGKRQDLDFGMWGKRQSPGLWGRSADPGQLGLWGKRQSRIGLWGRSYEPPQFEDLEDLKKKSAIPKPKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I864</accession>
    <name>A0A6P8I864_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Centrosomal protein of 57 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the translokin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563451.1">
        <property type="nucleotide sequence ID" value="XM_031707591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I864"/>
    <dbReference type="FunCoup" id="A0A6P8I864">
        <property type="interactions" value="2475"/>
    </dbReference>
    <dbReference type="GeneID" id="116298989"/>
    <dbReference type="KEGG" id="aten:116298989"/>
    <dbReference type="InParanoid" id="A0A6P8I864"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025913">
        <property type="entry name" value="Cep57_CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14073">
        <property type="entry name" value="Cep57_CLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome localisation" evidence="10">
        <location>
            <begin position="67"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="9">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563451.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55379" checksum="9D3B12B6959E81EE" modified="2020-12-02" version="1">MEDQGGRSTPPYLRSVRGVPDSPFRGSMRSEANSSISSYRDFPHAKKYQAEGLASPRGIAPQANSRAVISALKGLQEKIRKLELERTEAEDNLKRLATESKHYKDILQKEHHAKSTSQGIISKQNDDLQNDLQGAEARCHLLEKQLDYMRKMVQTAEMDRDNAVQRSAMLTQQISQQATADIKGQIGKLTGLEREHMKLTASQSLAESKIRELEERLRNEAHHRKLLEDKTVQLQTESERNRILLRAASPPPKIKKKKKKKVKAKSKPQPVPGNPPGHFHLNMGNIPFVVGKSASKSHSVGANIQQALSLLKGHNPALCNALAQRQARRCSSSTSSDSEGLEDLLLGLQDEFGHMSFEHQELGRQINETDDLVIREDLERELEHLVKRMEAKGEQIAMVKHQINKRSEQRTRPKYRPQPHVHVRPRSASARLPASGGEIEVVTTVKTKGSKGVFAGVENRIPQKPGVNADKNLKVLKGMQNLQSSLTKDDLHWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA23</accession>
    <name>A0A6P8IA23_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116300244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564928.1">
        <property type="nucleotide sequence ID" value="XM_031709068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IA23"/>
    <dbReference type="GeneID" id="116300244"/>
    <dbReference type="KEGG" id="aten:116300244"/>
    <dbReference type="InParanoid" id="A0A6P8IA23"/>
    <dbReference type="OrthoDB" id="5954510at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028100437" evidence="2">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564928.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="32936" checksum="52850573C48E66B6" modified="2020-12-02" version="1">MDLKLFAVLIASVIGLASAVVRWPTGTYGIPMPDAGCPDDETLKWKTGWTYHDTEDDNNQNQRSAIFHMPGNFSKHGIQQKFCIKDTPQGGSEFWPEGKYCLYKKGVCPTNMKTGYISWDDEQSELDLKDKHDGALPDGDYPETHTKINYCCMTKGNVNNPIQLPALKPFYLLSYGSAQCQKIAGTRVTSEFIKFDDDDQANTDKAYGAHPYGPSEDPFNLKVYYCYYEPGQESEDDLGTGKDVKSKIPTGKSSSGLAVAIGCGVAGAIVGTASIAFATKRILAHKARAAFDAMEPQPDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAH9</accession>
    <name>A0A6P8IAH9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transporter ZIP14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565148.1">
        <property type="nucleotide sequence ID" value="XM_031709288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAH9"/>
    <dbReference type="FunCoup" id="A0A6P8IAH9">
        <property type="interactions" value="591"/>
    </dbReference>
    <dbReference type="GeneID" id="116300416"/>
    <dbReference type="KEGG" id="aten:116300416"/>
    <dbReference type="InParanoid" id="A0A6P8IAH9"/>
    <dbReference type="OrthoDB" id="5989389at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565148.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="29919" checksum="8A9536F35EB3DCD7" modified="2020-12-02" version="1">MVLLYRSSWTSQLFVFIFVILLVPIHSNYRAHHVSHSGIRSANVVSPEDFTDELFEKYGSNGSLDDTQLKTMFENLGIGKDNEKTANNHAGVNERCFSSSSLLDVFSVNKTALNKQNFNKICPAIVQQIDSQKCSAAFSTSTYDGISTALAIFCEELPHELGDFAVLLNAGMSYKQALLCNFLSACTCFIGLVVGLLLGYSTSAVKWIYALAGGMFLYISLVDMLQEATEISCKEGEGSIKKNLKTFALQSFGILFGFVVMLILALYAEGISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAK9</accession>
    <name>A0A6P8IAK9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116298060</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in trafficking and recycling of synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562262.1">
        <property type="nucleotide sequence ID" value="XM_031706402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAK9"/>
    <dbReference type="FunCoup" id="A0A6P8IAK9">
        <property type="interactions" value="1560"/>
    </dbReference>
    <dbReference type="GeneID" id="116298060"/>
    <dbReference type="KEGG" id="aten:116298060"/>
    <dbReference type="InParanoid" id="A0A6P8IAK9"/>
    <dbReference type="OrthoDB" id="5597044at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031562262.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12357" checksum="086590CE06DF142F" modified="2020-12-02" version="1">MKSRSKVKYYKLSGEDDGYVDAQFIKPPPKVPLKAICLAAVLFSVGTILLVVGSLLFTGHFNVKYADRTYPLLILGSLMFIPGFYHVRLAYYAWKGYKGYSYDDIPDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBB7</accession>
    <name>A0A6P8IBB7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein F54H12.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116297892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562065.1">
        <property type="nucleotide sequence ID" value="XM_031706205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBB7"/>
    <dbReference type="GeneID" id="116297892"/>
    <dbReference type="KEGG" id="aten:116297892"/>
    <dbReference type="InParanoid" id="A0A6P8IBB7"/>
    <dbReference type="OrthoDB" id="5962415at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031562065.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34490" checksum="19E0E4EE77487C52" modified="2020-12-02" version="1">MTKILLEFDVEFHNGGAGANNALLTNTSSAVPINNIAHSLIKQIQLTINKGAVTVNADHYHLEAYFDRLLNYSEEEKKSLLSLEGWATDTPDKFDQLNPNDLAIANPAAWAGNAPTVAEVGDAIRAAATRVTPNQGAKERVGLCCQDRAVKFILRPVIPLFSSQRYLTPGCELKFRIQWNPRELVMMNGPTVGVTTITQPNASYRIVNYSPKLHIRHVDVNSELHIKMEAAMLENQDIALYPYFTNRTVTHTVPNGRRRAQMHNVFQGYRPNYMIIGFQRGDAFDGDIAHSPFNFQDMHQSSLRVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC64</accession>
    <name>A0A6P8IC64_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel protein Shal-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116298821</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563242.1">
        <property type="nucleotide sequence ID" value="XM_031707382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC64"/>
    <dbReference type="GeneID" id="116298821"/>
    <dbReference type="KEGG" id="aten:116298821"/>
    <dbReference type="InParanoid" id="A0A6P8IC64"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000081">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563242.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="53076" checksum="058728A78238D621" modified="2020-12-02" version="1">MDFFSGKKALSEGDSYAGVDEDGKEGKIDQEILELIAERAARKKAALKEREKSIQRAQNRRCLTTINVSGQRFVVDKDIFSRFPDTLLGSNFKESFFDSQRKEYFFDRDPEVFKYIIIFYKTGKLHFPEEECACCFDTECRYFGIQTDIMSDCCHEPFGEQTEDFKEYLRRNRPLEIPKVSDNQACLQILRRKMWKIFEDPGGNIFGLLLHYISAVFIVVSVISSVVETIPCGIQKCGKKYAKEFFLTEAVCVTLFTSEYVSRLFAAPKRWEFVKKFLSIIDLIAILPFYVGLISPKASEGPFTVLRVFRIFRIVKMSRHSTKVQQAGSSLRESFSELSFVFVVLAVMIIIFSSVIYYAESAYPDTNFTSIPATFWYTIVTMTTLGYGDLVPESIVGRLTGALCSLSGILVVALPAPVLEKNMKKARKGEEDDRLPLTFRENQETEGGNSEVAEEQCEVMKSDNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDD0</accession>
    <name>A0A6P8IDD0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116299620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564157.1">
        <property type="nucleotide sequence ID" value="XM_031708297.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299620"/>
    <dbReference type="KEGG" id="aten:116299620"/>
    <dbReference type="InParanoid" id="A0A6P8IDD0"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004720">
        <property type="term" value="F:protein-lysine 6-oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF4">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027613077" evidence="10">
        <location>
            <begin position="29"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1882"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="132"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="353"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="654"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="870"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1324"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1496"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1595"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1684"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1773"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1939"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1952"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="895"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="908"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1393"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031564157.1"/>
        </source>
    </evidence>
    <sequence length="1963" mass="213662" checksum="7C8E25DB575A58F5" modified="2020-12-02" version="1">MWPTSSSLKNLRWMWLVIWACCMLQIHAQKSNNPPVSVKDDFMDIHIHTVSKCPKGTFQKDRYCVTKCGPGFYGDTQYGNCFRCSKACRTCLDGPFNDKCSSCYEPFLLNGKSCTKECNEFQWKQGPPSRNIRLVGDNSHFEGRVEVYRDNTWGTICDDGFDINDAHVICRELMLGDALSAVSRGGLGKGDDSQPVWLTNLQCTGNETRLDECFHDPWGKHNCGHFEDVGVICSGPDSTRRCVGKCGPGFFEVPNSRNCGVCSSSCLTCANSSDSCLTCDRSLFLKDNKCVSDCGEGYFGSPDKGLCKKCDTNCRTCTGSPSNCIGCADDRFLSNNTCVTTCSNVQVGLKRRVRLTGKRSSSYEGRVEVLQDRGIWKTVCDDSWDFREATVVCRQLGLGRTIKATRGATFGPGSLPIWYDTLSCAGTEKSIFDCPTKGVLWSSRCFHSKDAGVICAGPQTGQALTNLCVSQCPEGYYKSYNDVCTPCSSSCAACIGYSTRCTKCKAPKFLKDYSCIETCGGSQYGHTPTRTCKVCDKKCVTCADGVDGTNCTSCSEPLALKDGKCTSSCKPNLFRYMGKCIQDCPMGFYKYAVNFTCVRCPDKCFTCQDDKSKKAPTCIMCNPPSVFDGTSCADNCTSGKVSVAIMNATGSSTVRLVNGSDYREGRVEIYHDGVWGTICDDGWDFMESKVLCRQLNLGSPVSKPLSHIAKGTGKIWLDDMFCIGRESALEDCRHRVWGQSNCNHNEDVIVRCSGPGIRKCQDKCSAGFYARNSVCELCDTSCATCDGNATNCIKCADGYYKYDSICVRSCGRERYLDQVKQECLPCNSKCDTCYGTPKNCTSCVPPLYRKGSDCLQNCGSWYKPATTHGIRLVKGKTSLEGRVEVLYNNEWGTICDDGWDLNDARVVCRMLGLGNATNAFSLSKFGQGFGRTWLDDVACLGTETTLAKCGHRGWGTENCEHTEDASVRCAGPDNSRDCIKDCTDGYYMSVNKTCGKCSPDCKLCAIFPDNCTACEANEFLNKSSARNTCVQDCGDGFYAEASSNQCKPCSVDCAACFGTPNNCTSCVSPKLLDTERHMCVKTCNAKSIISGIEDIRLSGTNNTLVGRLEIKYNGEWGTVCDDNFDIKDAQVACRQLKLGTAVSFKHQAFYGRGKGKILLDDLHCIGTEKRLLDCKMNSGGIGINNCGHTEDVGIACKGPDTSKRCISKCPDGFFEQAGVCQRCSQSCKTCDGGADKCKSCFAPSYLNLRSCVDKCPLGEYGNTKIRKCLVCSSNCQTCLDGETDAYCRTCKKGKVLKGSKCVESCGAMQSVAALLPSRPSTPSVRLVGGKSKQEGRVEVLHEETWGTVCDDNWDLKDANVVCRELGFGKALKAPLHAEFGKGSGTIWMDNVDCYGYESSLTQCRHHGWGINNCDSFHGEDASVVCDNTTIEDIANNYCREVLSLTCKDDNPCFPSVTCVDLSVLTKSGKKESICLECPDKYIGDGITCRAVSSLEPVFGTKPPKNITLTSGSVLRITCRSSSSVSPRVNSLINDWKKDGKPLNRDDIVSKRITVSSGQLVVHDVEQSDSGNYTCSLTNTAGSVEATTDVTINEFPRIRDISPNVVTKGMTGYISCSISSYPPANITWKKDGKELTSPRFISFSSNFTLVIKNVADEDKGEYECIAANELGQVSAKVSLTIGLPPSFEVFPKDQRTSKGEAKTLNCKAKGEPKPTITWKREGNVITPDENHVIGEGKLTIKYINMSDIGIYSCIARNPQKIIASFASIILMGTPSIDVPPVNMSVLTGANVSFYCRALGHPNPTITWKRNSKVVQTKSGAGNVVEDKLTLVDVKMSDASMITCEASNEYGTASKSSFLIVDGMSGITMLSSAAAKSEGLSTGAVVAIVVILLIILLVIVGVVLYRYYSGRAGPSTAFRYELGDDTGKPDRLTALKFKMRGGSKNSHEPMQMFDDSKPFVDHDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDM8</accession>
    <name>A0A6P8IDM8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein DDB_G0281931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564442.1">
        <property type="nucleotide sequence ID" value="XM_031708582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDM8"/>
    <dbReference type="GeneID" id="116299865"/>
    <dbReference type="KEGG" id="aten:116299865"/>
    <dbReference type="InParanoid" id="A0A6P8IDM8"/>
    <dbReference type="OrthoDB" id="5964333at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056047">
        <property type="entry name" value="CRMPA-like_DUF7630"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24633">
        <property type="entry name" value="DUF7630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7630" evidence="2">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564442.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62649" checksum="55F23885E9E872F8" modified="2020-12-02" version="1">MPCDEGYNCVNESVSLLSGFYWKWNSTDAKYRYTNFSAEIQVRNKTYNKSMTSYLLGIPKAYACPVAEACKGGLDSECSLGYEGPLCAVCSKGFYMLASTCRKCPSLPWIIAQVVLITVIITGLLIFMIKEKKSKSNKRSLSDAMTARLKIVIGFFQVTSGTISGFSFIKWPDVMISAIKYAELLQMNLLQIAPPQCLTRSLKTDIHVKLMLILAFNSTVVFLGLLYYYIKTRSKSRNGEGNENVKCSAQQQCFRAIFLILFISYPLTSSHIFMVLPEACQEICTSTEDKSCSYYLKSDYTVRCESQRFFWFSIFARVLLVYPVGFPLLVLYLLWKHYYKKTDPTKRRKEALGIALGLRFMYENYAEQVWFWEIIELVRKVILTSVILLLDAGSRFTIGITAIISGSYSISFAYFKPMTDVFEHWLQLTSLLATLVNMIVGILLVTQNEGSSATGEALDGAVIKVLLIGANAAVVAIMAARYLITLGQTFLAIRRNPRCSLSCCLFLFLTLNEASNEMAGVDTSSKGHKRQQNLQHNFGEPQLYLSQAGLSVELEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDW7</accession>
    <name>A0A6P8IDW7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116300046</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116300046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564667.1">
        <property type="nucleotide sequence ID" value="XM_031708807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDW7"/>
    <dbReference type="GeneID" id="116300046"/>
    <dbReference type="KEGG" id="aten:116300046"/>
    <dbReference type="InParanoid" id="A0A6P8IDW7"/>
    <dbReference type="OrthoDB" id="429969at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07064">
        <property type="entry name" value="AlkD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070">
        <property type="entry name" value="ARMADILLO-TYPE FOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070:SF1">
        <property type="entry name" value="DNA ALKYLATION REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031564667.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="32225" checksum="195CD7FA526BAB9B" modified="2020-12-02" version="1">MGKRKAAHSPLQDKIERKTKRIRREIRPQNETETGAQSKLMSVTQLVHKVQQTFAKNANQKNAVMRKKYMRNQFEFFGLKSPLRRSVSKEFLKVRFSVGEMRQLLEKLWLLPERDMQLFGIDYLDKHIKSFGDPVEELDSNLECLEYLIVNKSWWDTVDLIASHFVGYMVRTHPDKGKPLMERWIEDDNMWLRRTALLHQLSYKDQTDEKQLYRFCLSRAHEKEFFIQKAMGWALRQYAMTKPSSVKTFLHKNKTILSKLTYREAAKHLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEF9</accession>
    <name>A0A6P8IEF9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ELYS-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116299661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564225.1">
        <property type="nucleotide sequence ID" value="XM_031708365.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IEF9">
        <property type="interactions" value="2709"/>
    </dbReference>
    <dbReference type="GeneID" id="116299661"/>
    <dbReference type="KEGG" id="aten:116299661"/>
    <dbReference type="InParanoid" id="A0A6P8IEF9"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="5">
        <location>
            <begin position="8"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="762"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1322"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1327"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1393"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1433"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1469"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1496"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1527"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1573"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1603"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1634"/>
            <end position="1647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564225.1"/>
        </source>
    </evidence>
    <sequence length="1693" mass="188306" checksum="B8FE273C11F9BCA0" modified="2020-12-02" version="1">MQDVLSPNGSSDLISYASATIXCLERSDLSEDISSLISGSAFDNGKLAWLARGSSLEIVNTKTGLREAAWRFGWGSKEKRAVXISAVAAFPMGDRDRLVVGLKDLSGGQPGLVCMFDPYVSRVIKAVVVPYPVTTLESIVGAGGGDAPPSLLSIHLKLYFGIVAXGTEQGHTYLLDMRLDDDMEEFDEWNPSQIELVNSDKENIAAFREEARASGTHIAVEVEGKSHKSGKFNYRRPESGEKKIYSSGDIFVSAVKYIRQAGCLVIGYNFGCFQIWDLNAMILVYSSQMDQYEMSAITHFAYQEPENDPRCCSYLWVARGPLTIEDEPQTEVPTTLTLYQLIFATREVLPGYGIVYKNLGGCGRRFEHQLTADAHHLADATSVGSKIICCYTLEKESFSQEVSRADEGMSRDLTLMVCVWEAPSHDPLSSPLCHLGIFDVNRWYHSQMQPSIRDAMFGSKDSTCPFFAFFSLAEILDIANPDGIVNVYIDSNSITRFKSNIEPPLEQHFWPXSLKFDTCCLMETGLVHSKFYGMQRQILSSLREGGLSSLSEAHEYFNMCWAAGLLPRNFDISKSQEKNFHLEAILSVSLEHSLITFITTCIQKLGAGNVTHAGCNLRVILDWSWSKVVEIKEQLDQLSVPLFDGGGGTPDDQMLLMLDDMAVHLGHLKSVFQALISQSAPSSHQGVKDLEAKFQVVSILEMYLSLLLWLIRHGLLPEYSDDEDSSFNQSDALYSSSSFKKFYDSRRAELQHCGSELGSGGLMIDRIISQFDGLWVSTSGKEHYPPSSLHSLSTLYLLDKISPETKHSIVFYLLLDICGTNEELNSLNVADRFAKAFDLPYSVTKMIRAFWFLDHKDFENAVNILDDPALATVEIGPWQNNYIIKTLLFQGQFQKVLYFINTVHPTMHSPEDVRLHLTVLVANGLVTEAFNFQRNHRDPAINAELLFHFFTGCQQSGNISKVMQLPLNDVEEECFVQFLQQESFDAARELLVMYYLQRGRYVEGVRFNEELKQCTMNEQNPAILERTKVRNAIVDGYVRCLPRMQQKLIFAPDKGVTHKPTTLKEVPRPKPLSTVVHHVKEGRPVSHATILNSVMEKVVEARAPDTPQRRRSGAFVGTPITPRTTSISSDSHRMVFASLKKPEVVHEEPPKSSQSLLSTPLFLDKKRRKQLYSGADALTLLTTPRIEKHSSRQGSLSHHESISVSSTPQSILKVRRVVRRSSPRTSPSSSPLRRDSSDKPQVKQGYTLDFESQSKDSVDYPHETPSRRIRFATEDVSPSPTSSKASAVTFKEMPAEPQDVAMETTTSVKSVGFKEAVVSPLEQDADASLRLELSKSEEEEEGEPEVQITAAVVDLRGNSDVEDEEMVHEEEDYSSYELDESDNIIAEDSEEEVLIRKNQEKSEKIGSTVQEREALQMAGLSETDSEGPVMRSSPRTTSNEQQSLQRSVLQGSSLSENTESAPEDYSHAQVSPPKQSGSPKQPSPEPSPKISPHLTPKTTKLPESTDASLTMTPPKSPYTSPLGLPSHSKDAKEVKGHADDEERDSFAFSPPSVFRTPQTADVVAKSGEKQADDVSTPSTNFLFSPPLTRSMIKRHSLDVSALGKTSANKSTPNVSTGRRSLRPRSQTGRYTPCQSPSDSPISFISPAPSQPTSPKGRRKTKKLVPNSHHSMTLRSRTCPVRGTRSAKLPHAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IER8</accession>
    <name>A0A6P8IER8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Folate receptor gamma-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folate receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564630.1">
        <property type="nucleotide sequence ID" value="XM_031708770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IER8"/>
    <dbReference type="GeneID" id="116300011"/>
    <dbReference type="KEGG" id="aten:116300011"/>
    <dbReference type="InParanoid" id="A0A6P8IER8"/>
    <dbReference type="OrthoDB" id="567542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004269">
        <property type="entry name" value="Folate_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517">
        <property type="entry name" value="FOLATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517:SF14">
        <property type="entry name" value="FOLATE RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027641153" evidence="4">
        <location>
            <begin position="27"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="5">
        <location>
            <begin position="32"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564630.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26984" checksum="38D610373FEEB4DC" modified="2020-12-02" version="1">MESTRLISAMFLFAVIVCIQLVSVNPEPVEKCLDGRYHKPSPSPEGPDYADCFSWKNKSCCTAEFTIELKKNRVENIWNFTWNHCGNLSKECERYIKDEECFFQCEPNLIKWHIGKAKIREVPICRSFCHDWFEACKYDKTCVADWGEFNYTSGSYICPLNSKCQTFAEVYGDGKGLCNKMWGSSFKQEESSNCMVMRFDGPGNPNDKVTKPVQLGSTLIPSVVITLLASSVSSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF08</accession>
    <name>A0A6P8IF08_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Achaete-scute homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565080.1">
        <property type="nucleotide sequence ID" value="XM_031709220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300362"/>
    <dbReference type="KEGG" id="aten:116300362"/>
    <dbReference type="InParanoid" id="A0A6P8IF08"/>
    <dbReference type="OrthoDB" id="6241467at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11418">
        <property type="entry name" value="bHLH_TS_ASCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000029">
        <property type="entry name" value="Achaete-scute family bHLH transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565080.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21055" checksum="1E88DCA16F4F87EB" modified="2020-12-02" version="1">MSIKDIEKSSAFTIPTATTIRFSQMSEEENXEGSRMTNKYPLLAPVLTQTRRRRAVSTVKQKEPAVVARRNARERKRVKLVNDGFVRLRKHVPTDPKNKKLSKVKTLRSAIEYIRHLQHLLSQANKHQICTESDLDTAAGSSSIEWIATDLKREGEFKDEYSKTNIFSYSTQQRPRSADSSSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFQ4</accession>
    <name>A0A6P8IFQ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116300789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116300789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565591.1">
        <property type="nucleotide sequence ID" value="XM_031709731.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116300789"/>
    <dbReference type="InParanoid" id="A0A6P8IFQ4"/>
    <dbReference type="OrthoDB" id="5989012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027897">
        <property type="entry name" value="DUF4559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15112">
        <property type="entry name" value="DUF4559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="410"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="868"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1435"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031565591.1"/>
        </source>
    </evidence>
    <sequence length="1963" mass="224166" checksum="577B46661B6998E1" modified="2020-12-02" version="1">MEEARVVVSTSWQQSLQNEKYKNWLKVTHALSITCAGIRPYTEREAKAFHGIVTASLQGLPLCTCTYTRXPFHNXXTCLWAKELLKYHTKXKPTWXQSDASLWNDPXVGHWEVAKLYMPYGCAKGNSCAETDATGLLNLLXXCXYYKIDSXLVXKVKDTRNAWAHAAXQELDAANTTDALLSMKNFLQDAXLIGDADAXDALNEIIALENDDLIDFKDLETKVVNELRKSMTSMKDELVGKIDSMKGQEDIHANEIKEEIECVKTMVSYCMKVGQEREDVLSNNTSVLCNIQDQMDVLLHRLENLXSNNEERSRENSTVKAMKYSLKHLSLWAIIFILKVLRAIPRKVIIMIFLLGAITTLDXNLDEIGCSARTKSADVNGLMEIDFTRHLNRAREGFVGRQWLFKGISNSLENDEFKGVMIIAAPGFGKSALXSNLICSKLSSFSLHSKILGYHLCIHSHKNTQNGAKFVRNLESMIAGRLQEYESLVXNDKFIQRVLENEQCXSDPTACFEQGILTPLSRLRLRFLEPTMYIVIDALDECYNENEQGKGTSIVNILSNNMKMFPNWLKVIVTSRNVTDIRRTFSSLDVMDFLPEDPRNLQDIERFIFSQLRYSFLFQMKSFVVDDFSIQAMVNKSQGNFLYXKLVLXYLQTKGVSAATWNSLPTSLTEWLTSNSNRGGRFYVDVKKGNQLLADYYFKXIHEKSVNITTQFVYNLATYIVRGSSTKQHVYDFKNLNQKMVQVCDTSTNITALHIAAGEENEXTVALLLNFFENVDIEDNKGRTPAFYAARFDRVSNLRLLYQKGTSLAHTTSTLTCGNPNAEEDDVQDCEHQMCGYSLLHVASQRGHHQTMKFLLENNVSVSTLSGSGYSALHLXAKYNHSETIKTLMEHGAVPDSRCLYYAAMNGNSMAIRVFLENGAEDTCMNCNEMSNGYFKGQCHFLNLEDRQNYRQDCNTALHIAAIKNLSKIAKLLLKSTKKAVHCINFYGKDPLLEAVEKRHLKVTKLLLKSGANPSSICNYYSILDSLPFSWPCGYTPLHVAXXSGAAAIANLLLKYKADHNARDCEGLQPIHVASCYGHADILSILVEKGADINSKGPNDMTPIHYACKCQNDGIFDKLFELGANGTAITSDGNTSIHYIIQKHSIDEEFYLMDPYVATPIEPIDANYRSVIENPFKHKYPWMISMIRFLASFTKGKSYDLESMYRLKLMTLFVDIISNXSKSMLATLETSSWKFVALTSPLFYAYDIGVISDSQNLKDKLESMSEAHKLLFKALIRDDTDCASVISFIELNLIYYFDYLLGIGYDVNCNDLESSSRPLLAYLRQGGRNMAKVLVKHGVTVDIRCGELFEDSAFHLAAYHKVHYLQYLSVFRDPVKWVEYLEQENALFDYLFDEYDKITVGEQVKVVRVRDGPVTKAIKSHPRGYKIIDECLDDEGYTALHRAAQGGNVVAVKHLLDWGADATKESPEGFDALTLAIWYAVKYRPYFNFHKLNLLTSLEIEFASFTASAILSHLTRDNPFHVGCDATKKAPTILHLAATRGMWRFIDDLFVARGHYKVTGLTANCPTRDNITPMYLAKLHGGEDCDWDNPWCKVVGVLLKYGASMIYPDPLTEYSLVFNFLFHEVPGRLDLHLDKEELKMLQDVMKEFIRCSDFEDFDITDVFESDIVFLPTSISNIYVYRNGIQKLFLDATHPLFKTVDEFERMRNIFNHFLTLELNELRSIFVYLKNMDDVTLRCIRPNYQDQPRQISEEQSKSDMMYPEEFIKLLNDLERERLMTDIRKTSISFPPHEYTAAALNLNMCSPEAAAKMFETIESCLDNNRQVFRNYRKSLSRELKTAKQVFQQYLLELGRSDSSVIRTLKSYEKNLTCPIKMITYQYLKMKFLLKTIRFWDRQVRKISVYPSISKFVAQRITDVFLNDNAKEMTRFILELASKTPSDKYKYLKMLRFTKAPMFDRTLFNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFT4</accession>
    <name>A0A6P8IFT4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Fibrillin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116300762</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565548.1">
        <property type="nucleotide sequence ID" value="XM_031709688.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFT4">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="GeneID" id="116300762"/>
    <dbReference type="KEGG" id="aten:116300762"/>
    <dbReference type="InParanoid" id="A0A6P8IFT4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000044">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000097">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000003">
        <property type="entry name" value="fibrillin-1 isoform X1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000068">
        <property type="entry name" value="Latent transforming growth factor beta binding protein 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000019">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000096">
        <property type="entry name" value="Putative fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="47"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017878">
        <property type="entry name" value="TB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00683">
        <property type="entry name" value="TB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036312">
        <property type="entry name" value="Fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="48"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="46"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57581">
        <property type="entry name" value="TB module/8-cys domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="42"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="41"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
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    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
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        <location>
            <begin position="1"/>
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            <begin position="18"/>
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            <begin position="127"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031565548.1"/>
        </source>
    </evidence>
    <sequence length="2993" mass="327380" checksum="553749016B7C9B5C" modified="2020-12-02" version="1">MMFRLVLSFVFLAKTLSQFNPRGTTQPKQYNILKGPNVCGAAQGPRCCPGWQQRTSVGLCIVPICRFGCGSGGCSGPNRCRCPDGSFLPRCRGKIGASSCTILCFNGAQCKNNVCTCKPGFTGKFCETPICTQPCVNGGRCVGPNRCACPYGFTGNQCQADYRTGPCYTVIKNKMCHNQLIGIVCTRNLCCATVGKAWGNPCERCKAKPEPCERGFLPNFRSKACQDIDECKAIPNICGKGKCTNTVGSYKCVCESGKVLDPVSKKCIDINECETVPNICANGRCINTDGGYECNCSRGYVASTDKMYCIDATPGYCFEDIINGYCFKGLRATTTKAGCCCSMMKAKGWGTNCERCPAKGTSVYNKLCGMDLPTTAMPPPVNECATMTGLCPNGRCEDMPHGYRCVCNTGYVYRNGTCVDRNECVENPSLCPNSRCVNTEGSFRCTCNKGYKPGPDGRGCVDVNECVEQNVCENGRCTNTIGSFRCTCNTGYTLSLDKSRCDDMNECLKPNVCRNGRCVNVGGAFRCICKTGYELSEDNRNCVDTNECKSQGQMCRNGVCENTPGSYRCVCNSGFASTSEENRCEDINECISVQNVCLNGRCVNSPGNYRCVCDAGYAVSADGHRCVDIRRAQCFSKILNGQCSEPLLNLLTVSQCCCGMDNGGQRGWDTPCSPCPRKGTAEYKRVCCKGPGMACDGTDIDECQNTAGMKIGICENGNCRNTNGDFVCDCKTGYRSDSTRKRCIEIDECLENPQLCKGGTCKNLPGTYQCVCPTGFSFSSATQMCEDIDECAVKDQCVYGTCINSRGSFLCECPRGLTLDATKRICQDRRTAQCWTKIVLDKCEEPINGAVTREVCCQSALGKGWGSPCQKCPTLRQKCDPGYAVQNEPRCTDVDECSVFPGLCRNGICRNTPGSYRCECSPGLTLDLTRNVCVDLRKDTCYMSVSSAGCGKAFRGSYRKDDCCCSSVKAAGWGNPCQECPLQNTDEFKRLCGTDKPGFKLIGPRISDINECSMMEELCLNGRCVNKQGTFQCECNQGYGISADGRLCEDIDECIISAGLCGNGTCTNTPGAFRCDCYRGFRNAPMMMEVCIDINECEQSPCSDGRCVNTIGSYKCVCPDGMELMKDGVSCEDKNECSDPNVCIHGRCQNFNGGYQCICNIGFEPTANMKDCVDIDECLVENGRCAEVCNNTVGSYTCACNAGFTLQPDGRTCEDLNECRENPDICGKGNKCTNIVGGYFCTCNPGYSASVDRRSCIDVDECQEDPRLCTNGVCRNTPGSFKCLCGKGYEIAKGTTVCVDIDECKRNQSQCHENAYCSNEVGSFRCECKPGFVGDGLTCTDVDECNDGTAKCSIHGTCVNTPGSYQCVCETGYTGDGTECNDINECLNQPELCEHGQCVNKPGSYMCDCELGYLPAPDKMSCQDIDECKEFKDLCAHGRCENLPGMFRCICDRGFQLTRLGSNCTDIDECSLTGMCPNGRCVNRMGSYTCECDEDFVINRDGTGCIDMRKGLCFLQTRGNNTCLNPLRAVYRGICCCTVGKAWNGCDYCPRPGTKEYRKICPGGHGFVPNPNTLVIIDVDECQELPNVCSEGRCLNTIGSFQCTCSNGLRHDITTGRCVDIDECTEYQYICGLDGRCINTPGSYRCECPPGQVLDPVDGFCVDLGRHLCYHDXQIGVNPICKSSFSVNITRRDCCCTIGKAYLIKTCERCPTKGSPAYSVLCLRKVPPPITKIAPQVPPTTKPAGPVVVRTDFVTLSPSGTVYTDEAVTGPRTVAPTTPFIGIVTNECKLIPELCLYGRCIDLVEGYRCECPLGYKVNDKGITCEDVDECKMNPCMNGVCKNTFGSFVCVCPEGFTLDITGLICEDMDECGTPGYCENGRCKNMNGSFICDCNKGFQLTPNKRTCVDLNECVAGKDICGNGTCINTKGSYQCQCHEGFKLDGGEFCRDIDECITAEDICNNGLCFNIEGSFRCQCNIGYKLSFDQRNCVDINECTEIPNYCKNGRCTNTIGGARCECLAGYSLSXDGRQCVDLNECDTNPNYCFPGGICANTPGSYRCACNQGYVSSEDGTTCVDVREDYCFNTFKEDSCTDPRLEVVTKSACCCSKGQGWGDPCELCPSPNATTFSTLCPKGPGFGFNKTGKFVDLNECKMMPNLCRNGMCINSDGSFRCVCLIGFKLDVTGHQCIDENECVEKKDACGNGTCTNTEGSYQCVCNPGFAPGRQSPKCVDVDECKADRSLCAFRCINTPGSFRCVCPRGFELAGNGRHCKDVNECTRDPKLCPYLCKNFVGGYKCICAPGYVGDGRTKCIDINECQTQPGLCRNGVCRNIGGSYVCDCNVGYVRSKNGKRCEDTRKGLCFASVSINGVCEAVTKQMMQITKGQCCCTAGKAWGTSCEICPSQGTSAFRDLCVDPGTVTDKVCEMVPGLCKNGKCMNIIGGYRCMCNVGFKLSTNGRRCDDIDECQHTPKVCQFTCRNTVGSYECSCAIGYRLADDKKTCEDIDECVAGTHNCQYRCINTRGSYRCDCPVGYMKNGVTCVDKDECMMTPNLCGQGKCVNTPGSYRCTCNEGFTFDPKTMTCTDKDECKTQQPQYCQSGCINLVGSFRCSCQVGFVQDAYWNQCVDQNECSSYGRCGAARCINTLGSFYCGCNQGYVLGQGGQACQDVNECLTGQNPCSYGCNNKRGGFSCSCPQNFYPIGGGHCLSPYGEACYECALAKGETIPTGGVPLVESTDATQAPSTPPPAADSYSRQRLFADQARRNINQPPYRPQNQYQHPYRQQQTGQYGGFQQQQQQQQRPLQNQYYNQQPRQPQQQYRQPYRQPYRQPYQQPYQQPYGRTYPQGPSGYSYRYSSSQSTYTTAGGRRKRSLHRIKRIGLKYNMTSGDIILKLVPVLRSLNGTMEYMIEKANRSLFKVEHNAGTMILRARPGLKVGQMHKVWLKPKSLKQPRRTNSNEKKNAKEKPSHTERVKKAARVVGMREAMRFLLHLQIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFV8</accession>
    <name>A0A6P8IFV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centrosomal protein of 63 kDa-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565573.1">
        <property type="nucleotide sequence ID" value="XM_031709713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFV8"/>
    <dbReference type="FunCoup" id="A0A6P8IFV8">
        <property type="interactions" value="955"/>
    </dbReference>
    <dbReference type="GeneID" id="116300778"/>
    <dbReference type="KEGG" id="aten:116300778"/>
    <dbReference type="InParanoid" id="A0A6P8IFV8"/>
    <dbReference type="OrthoDB" id="5965120at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098535">
        <property type="term" value="P:de novo centriole assembly involved in multi-ciliated epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031470">
        <property type="entry name" value="CEP63/Deup1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875:SF3">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 63 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17045">
        <property type="entry name" value="CEP63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP63/Deup1 N-terminal" evidence="5">
        <location>
            <begin position="58"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="99"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="399"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="481"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565573.1"/>
        </source>
    </evidence>
    <sequence length="758" mass="88605" checksum="A941971464331D07" modified="2020-12-02" version="1">MPPTWHLKSIRHSLIQQAFGFKMSSFLCIKCEKKEALTSCLTCDGGLCTKCWDIMHYKLMRQIDLMVTAKKAEWENHMHAVQIQLEKRNKEVGFVRAQLEQKNQEVEKLQYRVDEMEMNQRDGISEYEQQVMHLKEEVDNLKYEHEKIQKKSEKQVLQGEKEKEQLVLDLNARDAEVQRLKERLEEYKLKVLEWEGARHAWEERIRGLENQKKTLLEKSDMTQQQLLGYQNQLNKRRNILDNMEHSRQREIRDLEAQLERIKEESESKEDTITELKDSLDSALSASKQQASEIAQLQEDLRVALDALQQLEDEKAHVLEELHSRDHLIQAAEVDQLKHADDIMKLEQSLTLKDEVIRKFEGATTRTENMELRRLKEDLRTSRIEMQSHIDSEAFLKEQLEHTTQKLETSNKTNAKLQAQLKRKEEELRKITEDDFQHLTAERNKLQEKLYSLEEGHAGALNGMKSEVDNLALQLHKRDTSMADVSEKLQRMEKELREATNRYDRCGAELQVTNAQLDALRIENKHLRDAARDQLDISEVYQGNMEFIAQLEADNRVLRMEVVSLREQLSAVEVNQQDKLRSALKKSQHTLDDIKQNEFRRHSELQTESERKIAALEARLESTIRIYETQLHFTQSENERLKMNQSKGKVYQQASAYTSLPNGTSVLPEYVPKRQPQDISHTSVSDYTDTEALTYADLGGAAIVSESERSATPRGSRRTSLTADFVAEENRRERELERILDGRIEDLKTNTDYIIHKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGD4</accession>
    <name>A0A6P8IGD4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">5-hydroxytryptamine receptor 1F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565743.1">
        <property type="nucleotide sequence ID" value="XM_031709883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300911"/>
    <dbReference type="KEGG" id="aten:116300911"/>
    <dbReference type="InParanoid" id="A0A6P8IGD4"/>
    <dbReference type="OrthoDB" id="5977853at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF129">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565743.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25250" checksum="1ACB6848479FF77A" modified="2020-12-02" version="1">MTFLQKSNCRPSTRQEKHLRQQTVKNLQNERVGEEESDPEAEDDEISAMESKLLTPLQASESMRALRDFVLASEESGAREHEFLRSLSITVGAFILCYLPIIVXLLRQAYYGLEPTASQAILFLSFTNTLINPVIYGLRSRDYRKAFLKLCIKDSDVISGCIASQRNRGTTKGTKSEQKQQNRAPGTXKVDNISELSSTSTSYSFVITRALFQTVLSEVLEDGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGR2</accession>
    <name>A0A6P8IGR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein 27 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566017.1">
        <property type="nucleotide sequence ID" value="XM_031710157.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IGR2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="116301149"/>
    <dbReference type="KEGG" id="aten:116301149"/>
    <dbReference type="InParanoid" id="A0A6P8IGR2"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566017.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26478" checksum="5C1A5A97485635F5" modified="2020-12-02" version="1">MQEFKINKLTQQMSSVDGYSLLKNISPSTTEEEIHGLYDKWAANYDEDIVAHGYVAHKPCSXFFEAEMERLFQERRFNKKILDAGAGTGLVGQHLKDLGYTDVDGLDISQEMLNIAFDKGIYKNLICXPISEKKIDQIQTGQYDALISSGTITIAHVKPPALDEIVRLVKPGGIICFTLRQDAYDTESMGYKKKIDELASAKKWEMIKSKIIVYHDKPDVRLDNCYLFTYKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II96</accession>
    <name>A0A6P8II96_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116301467</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031566390.1">
        <property type="nucleotide sequence ID" value="XM_031710530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8II96"/>
    <dbReference type="FunCoup" id="A0A6P8II96">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="GeneID" id="116301467"/>
    <dbReference type="KEGG" id="aten:116301467"/>
    <dbReference type="InParanoid" id="A0A6P8II96"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000006">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="198"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031566390.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="47221" checksum="3ED07BE296E00B07" modified="2020-12-02" version="1">MEKVEENNEKQARLNETMITIRSRLLEIKNTGKQVKMTATVEGEKHSKLHPQNKSQEMQYKLVLIYTPWFGIMPWPQLKNTYNFTHFNGKSCKESRCRLTYDKKDLARSDAVMFHGTDLPSVNTMKEMSRNRSLNQRWVFFIHENPYYTFINTNMYNGFFNWTMTYRRDSDIFAPYRYYTPLDSTETSINKKQRNYAQGKDKFIAWMVSNCGKLRDKVTAKLLKYVNVTVFGPCGKHFNQTNRCNRKTRDCEKLLKRFKFYLSFENRNCIDYVTEKYWYTSFNHDMVPIVLGPLKYDSKIAIPDSYINVMDFPSLKDLASYLKYLDKNDTAYNEYFQWKRKYKLGNMNPWKCQMCADLHNPNLPPKVYDDLGSYWDKKKSCEKYEEEVRKLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIC4</accession>
    <name>A0A6P8IIC4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Sodium-dependent multivitamin transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116301489</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71207"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566420.1">
        <property type="nucleotide sequence ID" value="XM_031710560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIC4"/>
    <dbReference type="FunCoup" id="A0A6P8IIC4">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="GeneID" id="116301489"/>
    <dbReference type="KEGG" id="aten:116301489"/>
    <dbReference type="InParanoid" id="A0A6P8IIC4"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098660">
        <property type="term" value="P:inorganic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031566420.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="67294" checksum="7030E241D1AC55D9" modified="2020-12-02" version="1">MAEKFSIVDYVVFSIMLLISAAIGIWYGCGPGGKQTTTKEYLLADRKMRIIPVAISLLVSYLSAITLLGVPSEIYTYGAQYYVIIVSYFIICGVVAVIFVPMFRRINITCANEYLERRYSVGVRMVGCIFFMLEYTLYLFVVLYAPSLALEAVAGIPLSASILTTGIVCTFYTSLGGLKAVIWTDVFQSVVMVAGLIIVVIVGSIEVGGLSKVWQINEDFGRMTFFDFNPDPKVRSTFWTLTLGGALTAMPVWTVSQTAVQRFLSVPTSAAARKVVWLNVPGLLFIVTLCCLDGLVIFAVYAGCDLRKDKKITSNDQVLPYFVINKLGHLQGLPGMFTACLYAGALSTASSALNAMALVILEDIIKKKMRDISDADQAKICKVIALSFGVIVIGGAFVVKYVGTMVLQLAYSIFGICGGPLLGIFLLGMFVRRANYKGAYAGIFVGAGMTTWVFLGSIIYPPNKYPGRRSVQECPWFNATLTNSTGIIENDWKPHSDGIADFYSISYLWFSGLSIMVSFVIGIIVSLVTETKADRAYAEELDPKLLFPTKDWLLSWLPGYDFEWDIEEEKPHDISPAISVIKIGDWGDADDDVSDEKKKSKSSDEKMEDTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIM2</accession>
    <name>A0A6P8IIM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha,alpha-trehalose-phosphate synthase [UDP-forming]-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116301643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031566589.1">
        <property type="nucleotide sequence ID" value="XM_031710729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIM2"/>
    <dbReference type="GeneID" id="116301643"/>
    <dbReference type="KEGG" id="aten:116301643"/>
    <dbReference type="InParanoid" id="A0A6P8IIM2"/>
    <dbReference type="OrthoDB" id="10064031at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031566589.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="58856" checksum="D74264A05D7C97A4" modified="2020-12-02" version="1">MELRKSAMESRDRKSCTPQLLVITDEAPYLFHRDNVTQELKMEKRDASGQQTGVKLLREIYLETKHFCALIGDESVDDDTFDECARRVREVDDKVQLVRVPIRTGLLSNNLKNAQFWPVYVQMDEKIEHLPNEDEAWKASKEVNKRFSEAVLEAVEEEHQSIVWIQDFRFWLAPKLVRQMLVKKELYCPIGTFIHIPFPPMKMLQKLKHYKEVLEGILGSDVICFHIKEFCTNFIECCEMILGCQVNYESLEVHYNGRKVTLHAIPVGIKYDLYANLSCKEFPEDCHDVIEDLYNDNADHKIIIGVDRLDYAKGLGNRVKAFQRLLEKHPEHDGKVQYLQVAVPVREGQPGFKHLKEEYEKLVSRTNAALQKKGFSSKINVVLENVPHHDLPVYYKRAHVGLVTPYRDALNLVSLEYVASQTSDPGVLVLSNYAGSAEFMHEALKVDPKNVEQMADTLHRALTMPKQERQTRMIKLRQRVKKELNIDQWVELNMEVLLKIKRINELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ26</accession>
    <name>A0A6P8IJ26_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301806</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566784.1">
        <property type="nucleotide sequence ID" value="XM_031710924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJ26"/>
    <dbReference type="GeneID" id="116301806"/>
    <dbReference type="KEGG" id="aten:116301806"/>
    <dbReference type="InParanoid" id="A0A6P8IJ26"/>
    <dbReference type="OrthoDB" id="5967564at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027827815" evidence="1">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566784.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="19246" checksum="6E16F1E7B0FE80E1" modified="2020-12-02" version="1">MSSIVFLLCLLSAVRSVDLRANQRGVRNDDSMIEELFQIKEDEWKDNSDVTFDKSESRLPRIWKTVQYSPRHYNPCTIQIKHWKTNEYLNQKQYDFQPDEIRVKHCNGTNSNGIVKRGCRTTMDCVTTYERRKFMRKTKGAPCTQWYAYQNDIPVGCECMISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ54</accession>
    <name>A0A6P8IJ54_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Uncharacterized protein LOC116301772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC116301772</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566749.1">
        <property type="nucleotide sequence ID" value="XM_031710889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566750.1">
        <property type="nucleotide sequence ID" value="XM_031710890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301772"/>
    <dbReference type="KEGG" id="aten:116301772"/>
    <dbReference type="OrthoDB" id="5968325at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653199" evidence="10">
        <location>
            <begin position="19"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1145"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1207"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1631"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1716"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1882"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="449"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="12">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1564"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1964"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1570"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031566750.1"/>
        </source>
    </evidence>
    <sequence length="1988" mass="227372" checksum="CB592C2A28377702" modified="2020-12-02" version="1">MTTLLVVLLGLCTFVVSGDVFRDVIRFQGFPLKEKESESAKLLPKKFFIRNNLKGDVEFRESKNMSVEVFLSGRKEDRKRFRVHYQMLNNESVVDLQVFLEPEPPNWPLIGGLAGAGLFLFVLVITVLCVVYKRHKERKIKEEMLDQEKFEKGKNVLEKRRWWMGSRRRRTTTSGSTVDEKKKARQNIQLELENVLDGEDKVKEKLRWWRGSKRRRITTSGSTADEKKKAQEKIKLELENIRGRENKVKDEANVFEVRKEGSGLEKIKTSPDNGGSGSENINTSPDKGGSGSENIKTSPDNGGSGSENIKTXPDNKGSGSESIKTSPEKKVSKPNAFLNTSLVLMSIIAVTMATQLVTPQARIVIRVPSSMVVSNSSIFFNERYQGRLIVSSDWKGDVKVFKQFAVSQAFSAVAALASCSNRCEYACDPLTKSCICYRGYKMAAKKCEDIDECAIGLHSCHTKSTCKNTIGSYRCTCPEGMWGDGVTCKKCTTTRTPCPENFYQSSKCTRTRDRICKACSPKCEKTTYQQYGCGLSFDRKCVDISRPLSRAKRNITDIIKIRSGAKVIIPTTILMENRLHVQSTNASFIAKEDRSFNFTLHRNSGFLVDVEVFDTHLTPMYKDYDGRRGSNNPNITLKTGFNEMRSQYCRHPAPDYYELAHKLHRERQTLVESATCKQTNINLCPENTEVGEKYHYRVINEPCRLATTDKVCKNSLECDLQESSDTLYCTRYVSILGDLFDVAEETFMETPVYVFDSKACKAAFLSCYQCRNNNCGKCARESRKNRCSCCYIDCLQPCDYFYALNCSAKRLQNVCAKGDVSEFKLTPKYSDNLKLQFNCYLEHDPPKXLYTLRYRVRYEDGTIFTSGWISKTVKHPQSKKFLAKGXNMLDSLRVSYDSEKIREYFLKAKRSNFKEDFRYSVAEMNTKRASFIPSTTIKKIQPLRPFSLQIGDGTWNSRATCRKLSYWSSMLGNDFSKFTTPRIRHLGMTNGGAFGYEVADPGSPPSMSVQISNEESILKHLHNTSSIVNDDTFKSSIRRKENSWVISLEGKLSHCPSVVGLSVIDELDGVKVIESDLLILCPRKKFEAEVDIPRQGKEDRERLFSVFLSDSQQEYKLQVALVDKLSRKQKVTFRKTEKDTKRGPFMILMPLFVTTGFVLLALIALLVYAQKTAKKQSKMELASASGWVWVEDSRKEKDKNRLKRRHVILVVFVVIVRLVYSLVFTFSVALAILILLHADNMKIINDYRSFVQRKGQESKYMSLRMDQFREKEIKASVDQSADIQRACDHSLGIQLKWLQYNMSCTLQSNHMKMFNKISQRVIDRVTDDVEQLERQVKEXVRSFSESTKHKISSLKLKVEHYGRRVYDNKWFSLPKVAYNLRNKRKKREIPGGKLQISEHLQEWQKQSNSQIEGALKILSRKRRSFSGSKXIGFLDFIGVLDQRQVISLEKSINDRLNSLEESLKGFKQVMASGTPPTLPLSTAFLCPLRYLTKEAKKDIERGIKQGLGEICDATKNGIQKDIHCFSLNISSFCAEKDGDDVLGXDKKLDSSSQRVYFEKKTGIDSTQNTSSANKSSIIKSSDGQSHYNVEKGDALEEQIDSQKEESLKRQGKLKEQSNVYKNEAFSSVKQTIVYVLGTIDALLFVFRCLKTYQIVMKLLYGFEETIEHNVYEFQSPTKKQKIADILGRIFDIFAKAFTKFIAIIKNLQKKVFRTNIVPLTIVLVIGAAVFYLIIFLSLNVMNVTVIEELGGYRLISARLDSDFEFTNAAIADHIKYLNEHDMKLYKKSVSKTLRQYNDMLKNFNNAQTQRFKKFNEQICSISKDKCIPLMPDFPKVSFSSCIIGRIEAPKFDDYKGTQYRYKLKFESKKYVDAARNIFLDTLYFILAVVLSFGVIIIFSTIVFYFLKSRDMVRIKYIHVYPTLPPEILKEYGLEDMNDLPVRNEMKNSTDSINRVKIPDKFVQNSKENSMERQNSSNKSLGSNTLTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK27</accession>
    <name>A0A6P8IK27_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116302189</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116302189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567276.1">
        <property type="nucleotide sequence ID" value="XM_031711416.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116302189"/>
    <dbReference type="InParanoid" id="A0A6P8IK27"/>
    <dbReference type="OrthoDB" id="5986940at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055353">
        <property type="entry name" value="DUF7619"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050708">
        <property type="entry name" value="T6SS_VgrG/RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32305">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32305:SF15">
        <property type="entry name" value="PROTEIN RHSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24595">
        <property type="entry name" value="DUF7619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3808"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="3495"/>
            <end position="3529"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="3761"/>
            <end position="3795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3318"/>
            <end position="3344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3842"/>
            <end position="3863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="3160"/>
            <end position="3191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3323"/>
            <end position="3333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="3519"/>
            <end position="3528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="3785"/>
            <end position="3794"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="11">
        <location>
            <position position="879"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="11">
        <location>
            <position position="1745"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="11">
        <location>
            <position position="2119"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="11">
        <location>
            <position position="3415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031567276.1"/>
        </source>
    </evidence>
    <sequence length="3863" mass="431078" checksum="96660C714BF7C8E7" modified="2020-12-02" version="1">MGWYAVAIMVEDFTDHLSWTPLSSVPLQFLVQVFNSAANCTSKPEFSGETRASGSCVGVXHRSTFKERLVAKSQGKGNSIVEIKTISPSGLTKSSLAQYSANEWYVNVTWTPSQSQVDPVIFCYTAIDAHGLSSPQICITFLAGVAPPYMVDDSHYPTGLIYPDHSKWVMRFDKEFVRPKRSRYIRIFRXDGTEVYTVDASISHDVIYPAGSLGRTLEIRPSLRFIEKTTYYMLLDPGIVQGTRYCGPESPPMRDPNFWRFTIRDITPPVVTFLSTPYVTNNSTTITWKINEPATTLCTVSTPDGTTVQACNESWXGSGLKEGYHWISVTATDXGENTAQPVTHYWNVDLTPPEPYLTTKPQAVSKETSSTFQFSCRRDSPCYYECXVTXDGANPTYSTCYGSGFVARNLANDVVYVFRLKARDRVRNQAQVLLYKWRVDLQPPQFSSIQSSSINCTRSAMSSTVNKPNVTDNEDPMPAMTHKDTPLQHGCGIERVWTATDRAGNVATAKQTITIRSSVAPVINLIGSIVVACPTTNKIDDDIKKTINVSHPCGIPTRLSFTDSLAALYCGTTITRTWRARDNCGHDVTAAQNIKILALQLPNYPKNGQVNVDLNQYFNWPQYPGAVSYRVYIWKSTTAKPTTPTAARTSRYFYTTSGQLPHGTQMRWQIEYVRGSGEIIPSPVWGFVTRHFPDFRIDSISLPPNAFSGQTVSVSWTVGNIGGIGNAAFRWQDTIYIGRTTTFSQARRMSTVSQXRFLAPNDAYVGRATLQLRDDDIGVFYVFVVTDAWNQIRDIDRSNNRKTSPTSVKVSLTPPPNLVVTTIVLPTSSFSGKSILVKWIVKNQGVGITRSTRWVDQLYFSKDNNLDNDDNYLGSKVHDGFLSVHQTYTETMSVNVPRAIFGDYFIIVKTDATDVVFENTGENDNIKASTSSFKVFLSPPPDLVVSSIDVQSKFSTGDTASIAYRVTNNGXGTPFQTWWRDQVLLINLQTKERRVIASPIYSGVLPSGSSYTRKVSFDIPPKMKTGNYTLSVHIDIYNQVFEFTYRNNNIISTNFTISQALPDLVVPKVTGVVTSDPIATYVHVSFTVHNNGKGTTYGAPWLDFVYLSPSKSFSWNTARNLGAVTRKTNLLPNESYDMTATKFRVPRDVFGLRYVFVLVDYYSSVLEQNNGNNQNHSEVVIIPQNFPDLALEKFDVLSGAFAYSGDSINVSWIXRNNGSRSTLEYFWTDVVYLSNSTALGFGEKKIYEISVQPRLLPGQVYKHKATVSIPENMYGDFFLLIKINSNDFLNENGSIANNNASTRLSLEEMPLPNLEMVKVTYQNESLENLIQVNWKVKNVGYSMTKIKFWTDQILLSPTTSKLTGSGVYNLGSLDIKAKLYFQQEYSASATVSIPRGVAGRHYVHVIANHQGKLRENSRDQGNNGHFIIYIPSESSNGAGSGGLNPVHLPALEIKLHNNVHTNVTCDDSFLFSFQILNEGKGDASVYSWTDXVYLYSKANGSLQEIIDYGKPLASRIHTGGLRVNASYTVNTIITISCFGRMLDGYLYAFSDVYNRTGWNTPPIACSNKIYIQTGPLPDLLGIFINSSLRTQEGMPLKASFNVSNFGEGSTKSGWAYALYLSEDVLQDXFDLKLASIATNLLLAQNRSVLLEATIFIPYDMVGSDYYLLLEVDSGNLVYELNEDNNVAYVLLKIQNTVRTDILVSSVTTSPMTLKLGSDIKVDWTLRNNGTQIAKGYKCDTVYLSEDXVWQIDDTEVAQPKCEFTSLLPYNNGVNRDRAFSLQKPLPLVAQGQYRGLVKSRSNIRDPFPNNNIKAGPKNINVTFPLLSLGSCVEADNGISVFIINDVPPEMTLIVTARVNVVTSFQDLYLRXNKPASSYHYDGKSKFAMSXKQDALVTPTKKGSYYVMLQRNDQTPAPGVKSRVCAKLAKFEILNIFPTTVAPLGNVTLRVEGTLFGWKLEVFLISKDEEIKIKAKRVYRFSSMLLYATFNVQGLTEGKTFRCKIXDTAKNANAVFKDPVNVTNGVPGKLTVTMNRPQAIRLLDTGDITXSYQNIGDTDLSSPIIMFSANEKSLLRYVQDGLQPSTYDKSLFVVAQPLEGPGGILPPKSSGRLRFQAKXLPGSGTGRSKLSVRSLLDNDEPHLFMESKXELKPNHLSDDLWEPVWKNFLSSVGTTQKSFNRRLSSVATQMSLDGRRLHMVDELVKFQLDFANGVQSGHALLDIIDVADQSSSSLLTLRLERIYSPFLTRRRGKGIFGVGWIAPWCETSVNFTNSSVIQILHMRDMITFQLVKTGFFLADRNRNIEIKHNDMIVNGVASDESEQLVFDLQTKKLKEIRRVNAENETINVTSYTADNMPSQLEHSTGGSITIDFNSRGLVRKVVLIQSNGERLVSLYTYDPEVPLLSSITSDEKTSSFSYTSNQDLESVTYPNGATLRYTYNPDTGFLEKIVGLTPEGQTSKAVEFQYNWDGLVKVINLVDNSSTTFAFDETMNALSITGNDGIPFRTRTTISGSTIVKSLIHGDQVVXQETLDTDKMTLQVEDANGDKVIYLFENDGIPQNITDAAGNVFRFSYDNTTKRLSESRFPDGTREMFSYDTNKNMKSKXTRNGKQILYEHGEKGNLVKKSVPDVGPTYYLQDSRGNIIMATNKEGTVTLRYNRDNKPTSVTYPDGRHLEYRYNKNGQRIGLSENSTGYNVTYHYDNYNSLSEVRTTGPGRTQTLLRIEYDADGKLKKRILGNNGYSEYFYYPETKRLRKLSNVLPFGNISSSFEYDYDDKGRPIKITSKDGIRLFAYDAASQLVGWTDVMKNGSRYTHTYEYDSRGNRVFSTNGGHRENYESNNVNRYMSVGNNKFIYDKNGNMLSKKNTKSRAKDVKYVFSEENVLLQTETANERCDYVYDLLGNLYKKKCTSGETRYVIDPFGIFGSNMIAQISGGISDFFVHSEQGILARLNWHGSATYYEFSGEGSVTGLIGPNGEHLNSYQYDPFGKIMYSHETVSNDFLFVGQWGVVGEKGIPFLYRMRERFYDAEIGRFMSYDPLGYKTLDTNLYQYGNNNPMLFKDPQGRFAVSLLASGGSGVFWYGLDKISKGEKITPGGIVGSFVSGAITGTVKTFNPYANAAIGGVAAGIQYRIENFIDGKPYNNKDFHVSVIKGTIPSIVSKIVIIDRLVDRYRKQIEEAKKKIKEACEKVKTKWRNTKEYINDIIEWMRSIDPNDIIGPTGFGDSRFIAEDTLLDYMIRFENDPNATAPAQRVVITHKLDQDLDPRTFRIGSFGFGNFTKEQPPSPFLQETLDFSNDRNLLVRVTAGIDVVQNEATWDLQSLDPRTGEPPRDPRRGFLPPNNGTTGQGYVTFSVRVKSGVKPLTRIDAKASIVFDRNEAIDTPPIFNTIDNSEPNTNLTVLQDLLKKGSLAVVLDKEDIGTGVQSVDIYYQQVQGEEMSRLMHPSFKQLLDDVTEDTVILPLAPGKSYRLVTSTVDHVGNKRGLEFSRSIFVDFPERIGSCSHLNNCSDHGTCSMFSVCICERRFYGMNCSQEKPXLAPPVLEAWTSGGTEDKPIPMYLFARVGNVTIEDPILSLNITILGLPESFIISRGMRSGETVLLRKEDFGNMTLTPAKDFAGNLTLNISAELKTEYEESLTTTLLPFSVTARADVPNLITQDACATNISNTTWTIPLFINSSLTDIDGSESLSVTLSGLPDGYELNKEPENGTHAQYLEPASLTGLVAQHEGMFKPFLLKVVAASVEKSNGDSVNVTRMINVTRCIVKFTCYAVNNCSNHGVCVAPDECRCETGYAGSDCSEESGVTEKMQIDMIIGIILGGVLFLNLMVLVICCLIQLKKDQAKNKISTRNTRRNMQSQYNNPSFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ22</accession>
    <name>A0A6P8IQ22_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Protein phosphatase 1 regulatory subunit 12B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116303721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569171.1">
        <property type="nucleotide sequence ID" value="XM_031713311.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569172.1">
        <property type="nucleotide sequence ID" value="XM_031713312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303721"/>
    <dbReference type="KEGG" id="aten:116303721"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026117">
        <property type="entry name" value="Par-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15093:SF1">
        <property type="entry name" value="PRKC APOPTOSIS WT1 REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15093">
        <property type="entry name" value="PROSTATE APOPTOSIS RESPONSE PROTEIN PAR-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="3">
        <location>
            <begin position="189"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569172.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29106" checksum="F589097D48F88953" modified="2020-12-02" version="1">MADTEESLYKPSRHRRDRTERSHRRRMADGRDTSTGNTDLNSSNLGDSGEVNEQLLSPESAEREVSPRIKDKRRSKSKDEPEANASEEAPTEPAAETGESPGRTRIKKEKKSENSARKRREKKNLREKRRSTGVVIMPTGESDDEDNEEQKAMKAYTKQNELLVPGAEPDDIVVANAKGVPNIRIEDKVKNDIDTIXQQKLSEKVEEYELQIDDFKAKLERANKDLEQLRLDNQRLKDENSALLRVVNQLSTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ28</accession>
    <name>A0A6P8IQ28_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC116303578</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116303578</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569004.1">
        <property type="nucleotide sequence ID" value="XM_031713144.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303578"/>
    <dbReference type="KEGG" id="aten:116303578"/>
    <dbReference type="InParanoid" id="A0A6P8IQ28"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028087786" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="197"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="313"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="539"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="656"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="760"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="861"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="12">
        <location>
            <begin position="1367"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="14">
        <location>
            <begin position="1498"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031569004.1"/>
        </source>
    </evidence>
    <sequence length="1682" mass="188184" checksum="F1316DB94C84524B" modified="2020-12-02" version="1">MLLKYFLVISTVVVTFVPYKATGVMVNPVENTEEGTGPGSQPSGQHKAVPISMSSRSGQRLQIPPYQECFKYTILSNADHAQEALTFQPLPNCDPFTPGWYRFSGDAGDKMPSTCVPYLRCGTLAPGWMNANHPLTNGSIIQREVCFNWNGNCCEYKTNIRVRNRGHFYVYEFPITPNCWSRYCGNALGPLNKTMQCGGNLTSLTGQITSPGYPNYMEPITCHWTIKSPFDGNILLYFENITLGHGDCSSNSILVDTNGQTQTFCTTQKDSMSVIGQKVVNIHCHSTGWKMKAGFKVRYAMVNGNLENAETQSKWNISVKVNGSSAIEVSWQALNGSFLKPSEYVYGYVVVCKPVNQRSLYVLTEPDTATISISGLTGGTEYKVQVVALVSGYGKKNIKPMFGSNKITVNSDKGECKYYNNLTSWDRAQGVAGDAKCDRYFLGSLGIVWYRFSGMAGTQIATSCVPKSRCGTAAPGWMSGTHPAVRDGIVTRTVCYHWIENCCTFYNTIKVRNCGGFYVYKLYPQHFCNLRYCGNKGGCGKSINDTSGTLTSPGYPTRIYWNSKCQWNFTAPSPSGVIVVIVEHLSIPISSRCLVFNLTFEDSNGLQIGKVCGVRRFITWMSRGSAKLRFHSSRATSRWVGFKARYFVFSGALTNIPESLQWPGVSVQPISSTAITVQWGPHPALPGSPSVTEYLIICVPDGLPLNATVFTTDISQNSLVENGLMKYTNYTTQIVVQNSQNNFQYLGSQKIYKTTSEDVPSEGPANISAIAKGNAMMVSWQPIPKLARNGIITYYVIFYKKAWTSENWAEMNVGKPTNENMPMTAYLRGLEPATEYRIQIAGVTTVGVGTKSKAVFAISGCDDVKNATGNQFTWTFSSPRHPGNYLSNLDCTWQIFSEKKMNVYVVFYTFHVEDGCSDKVVVKQADGKINDYCGKKDPFAVKLSSEAGFVKLKTDGGLEESGFLARVFAVTNSLGVQYDIEPGQKTTTITFSLQKYKGSILEYVVLYKKGSSSDLEYNVTLTTTNKAILTGLELRYEYQAFVLIHTTKGVFRGPMSKTFGLLRPSATPGTKMPEPTSLPKVNEKLGMYLYGVAAGDSLLPNTHDYSTRCFTLDIPDDGMQFFTKRHHKIHICRNGLLLFETPQLIRWPHRFSEQHELLRNAAMLAPYWALTDVEDSFVTLGISKVYYQEYKDTDNSWESKTILPQASYHVKNHFDTSGVNSLVANFKAKWVLKVTWVDLRFPSTTKLALSQKNTFQAVVMTDGTLSFAMYNYPPNGIQWAAPTQRKYYSLYAAYNNHGLPVVGFNSGEHNRVVPRYYDVIGSGTPGIVNINQLNGSTVYPTNKLDSPWDFKIHESPGTWFFRLEDINRVDFKQQCIDWYKREPDHRKYTEHLEPCPCTYRQAWWDERFEMDPQERHRICAYTVFKSVHGWGQECCYERSTGALIKGYPDGGTARKQYLRVKKTIKENEYITCCIYSNMCHLYYKRRPTNNCFGYKETEWSWLWGDPHFVTLDGLNYTFNGLGEYIMADISNGLFQLQARTKLVEGGGKATVFVSAVARQTGTSAVQVNLKSDEGLEVLVNGTVIDHSTLTNTTTRYNGSVALSRPDNTSITVLFPCGISVKMTDVKDSLAILLAAPERFKNKTRGLLGVWNDDPEDDLTTPTGRVLPTNATGRMLHYEFGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQF5</accession>
    <name>A0A6P8IQF5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568655.1">
        <property type="nucleotide sequence ID" value="XM_031712795.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303280"/>
    <dbReference type="KEGG" id="aten:116303280"/>
    <dbReference type="InParanoid" id="A0A6P8IQF5"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568655.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="29881" checksum="6C0AED6BD425791E" modified="2020-12-02" version="1">MNSSTGTNSYVVPVILWNRLQEELKQLKENVAASAAAKSQAGGAIAGVDRDGNVRMNELMHTMAVQQSLQQSPKVEFVKYADKMVKQVMSDPSLTPDERVRFMTNYAASFQDQKAMAQKGLTPATAPAPGPAPAPAPGPAPGPAPALVPGPGSVVGTTPAWSLPAGPSGVKLGPGSVTPKGTGTGPGPGRGRGRGYTGKGKTPLKRQIHFGNVXGTSTPLNNLRPQQIKQLKKVDNLIQAIDQKSKKIAQDTNLTPEQKRAKQGVLTRGRTKYKVIRNDILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITE5</accession>
    <name>A0A6P8ITE5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">A.superbus venom factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116304832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570486.1">
        <property type="nucleotide sequence ID" value="XM_031714626.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ITE5">
        <property type="interactions" value="685"/>
    </dbReference>
    <dbReference type="GeneID" id="116304832"/>
    <dbReference type="KEGG" id="aten:116304832"/>
    <dbReference type="InParanoid" id="A0A6P8ITE5"/>
    <dbReference type="OrthoDB" id="5967075at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02896">
        <property type="entry name" value="complement_C3_C4_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018081">
        <property type="entry name" value="Anaphylatoxin_comp_syst"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041425">
        <property type="entry name" value="C3/4/5_MG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF166">
        <property type="entry name" value="NTR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17790">
        <property type="entry name" value="MG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47686">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027863800" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="9">
        <location>
            <begin position="1612"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1409"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1409"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031570486.1"/>
        </source>
    </evidence>
    <sequence length="1748" mass="196247" checksum="D8EF0FE1317AE747" modified="2020-12-02" version="1">MGPNVKLKCLLIFLAMGLSLVFCKSPGYIILAPNVFHVGLEETVAVTVTGVTRPVKVKFFLQEFPNRKTNFSHVEGLFASDKSGLLKIKVNPSDIPSHDTEYNQYLYLVATCNDPQLVFHKETKVLLSYRDKIVLVQTDKPIYTPKQTVKFRVMPLDFNLKPSKDKVNILIKNPQGILAQRWTNVSSDTGFITKALHLGDHSLIGNWTIAITYGYLNSQNTTVKFEVKEYVLPRFSLRIIGPSYVLPSAKRIHIAIVSKYTYGKPVIGSVMTRLTLTGKGETEIAFFVNTSKLNDGKVQLKIDTSLLKNHALRPWFPDGRRLRIDADVVEQATGARESAVDSSIYFVKTPFHLSYESTAMYFKPSMPYVIKIDVKYPNKRPASHLTVQISAKGTSDTGKPVNVMQKLNNQIRKHMKGNTDGEGRVEFILDVPRSVKDIEVEVETKDDRLGEANAAVKFRAKAYNSPSKRYLHIRPKKPKGIVGVVSMWDVFQNGNISSLTFMVLSRGRILLQVLTRPKDGVNVVSTFTFTVTKEMSPACRVLAYYVTKDNEVVADSAVMEVEERFPNKVRLTSPGKHAKKERPGMDYLIEVESTPGSRVGLLGVDESVYLLRNKNRLTKKKVFKDVKNLDLGCGVGPGKNNQDVFKNSGLMVITNGMDPPKERTDFGCSAPETKKRRKRSISEQEKKTCCLNGKLFSRASCTMRARFMAMNGASLECREVFLNCCRIAWNEKAPVVDKRQRQVFEQKNGFFGGGNEVDDIQSEQVRKYFPETWIFDEEVTGPDGRMMLPVTLPDTITTWVLQAISISNTSGFAMTSPSRITTFKNFFVSLSLPYSVQRGEQLSVVATIFNYGTEMSHFEVSLSGSREFCSTERPGDKTKPIALSVKANDAKSVTFPIVPIQLGKIPIQVSATRKIYGIEDDVGSDVVQKDLLVVPEGVERRFVHSLVLDPQGVLRDEKPTNQNVTTPAPTLKNARIVQDGQQINTVMLTVPSRAIPGSIKASIYLTGNLIGPVVTNLIKGGLENILRMPMGCGEQNMIFLAPNVYVLEYLTNTRQVTAEVETRAYRFIQQGYQQELGFRRTDKSFSAFGETRPGSTWLTAFVVKVFCAARKFDGIAIDDDLVCDSIKWLLSNQRLDGAFPEVHDLVHKSLLGGVHGDVAMTAFVLTALLECKCSSQNSDVNIRRAVQYLESELASLNKAHVLALTTYSLALAKSTLSSKANQRLFQMSSFDKDQNTRHWDIGGPALNVETAGYALLSQLHLGRLKHGGPIVKWLTEQRNAEGGFVSTQDTCVALQALAKYSEKTAGAQLDLRVSVTPEKDAIWRRTFHVEKSNALILRKVDITPFLGGELFIDSSGTGVGQMQIEILHNVPSSKNETCLFDLRVSVQEEFDGNKVSDDGLFIVGRSTRRAKRALRSRRKKKSKKCKKRKGKRRHCSKPASKKSPKKSNRNKKPKKNKRRNKKKKNQKKKEEKQKTQARAPDSLYVEACTRFRKPGKSGMTIMDIGIFTGFEPDEKSLIELKKNVQPTVDRFEISDRSIVLYISEVFSSKEFCAHFKVNRVFGVGAVQPVPIKVYDYYEPGDSCTKFYSPDVKSELRLGICKGEQCKCTQDGCSSCNIESLDVDHMLKKACRDHEFVFKGEIALVDEDGKGSRSWLNYFIIIQKIFRKLDNSKLKVGDHIEYKKRAGCRCPELRETGEYLFMGQEGNGKQYVLDKKTFVVPWEGKTHDERNMIVAFKARMNRGYTCPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITJ5</accession>
    <name>A0A6P8ITJ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">POC1 centriolar protein homolog A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat POC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570541.1">
        <property type="nucleotide sequence ID" value="XM_031714681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITJ5"/>
    <dbReference type="FunCoup" id="A0A6P8ITJ5">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="GeneID" id="116304893"/>
    <dbReference type="KEGG" id="aten:116304893"/>
    <dbReference type="InParanoid" id="A0A6P8ITJ5"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000235">
        <property type="entry name" value="POC1 centriolar protein homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570541.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51357" checksum="02CC973FF35EB632" modified="2020-12-02" version="1">MTSSLEDPTLERHFKGHRDTVTSVDFNPNMKQLVTGSMDSSLMIWHFKHHMRAYRFVGHKDAVLSVKFSPSGHLIASASRDKTVRLWVPSVKGESTVFKAHTATVRSVDFSSDGQSLLTASDDKSLKIWTVHRQKFQYSLNAHMNWVRCAKFSPDGRLIVSGSDDKTIKLWDRTSKDCVHTFYDPGGFVNSVAFHPSGTCIAAGGTDNTVKVWDIRMNKLLQHYQAHTGAVNSMSFHPSGNYLVSASNDTTLKVLDLMEGRLFYTLHGHQGPATSVVFSRNGEYFASGSSDEQVMVWKTNFDKIDYQEVLKAHRKRAAPGSPCHTHDPPPPRTPPRHTVPQISAAAEPKDMGAQDPEVVEVGPAMFSIPRQQSKLDEFTSHNGQPPVGLGGVVNDPPMTTPLERRDIPPQLANTLEHIVGQLDVLTQTVSILEQRLSMTEDKLRECLDNQQKISLQIRPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV20</accession>
    <name>A0A6P8IV20_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 14">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116305172</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Chromosome</location>
            <location evidence="14">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_031570889.1">
        <property type="nucleotide sequence ID" value="XM_031715029.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IV20">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="GeneID" id="116305172"/>
    <dbReference type="KEGG" id="aten:116305172"/>
    <dbReference type="InParanoid" id="A0A6P8IV20"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049915">
        <property type="entry name" value="TERT_TEN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11474">
        <property type="entry name" value="TEN_TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 14" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="767"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="561"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031570889.1"/>
        </source>
    </evidence>
    <sequence length="1288" mass="149878" checksum="3E33A7E42166609B" modified="2020-12-02" version="1">MKPRELFATFYPKQRTLLDYLSAVKDRLHCPNDPKAYNDMLKQTIVCYHDIEVDLRCFTPSVREGCHMRDVLQRVIEISCHSLIGSAGNIVSIGYQLVRDRNNSTGCASSTATVVNKYPNSAVDFLSSKCWQALHKRIGDDLMIHLLKDVSLFVMVKNQCYMQVAGYPMYNLECIRHGEQEDELSSTTQEMPDDANMPKETIQDRMLQEAVFPSLPVRQDKPLEQDFRQNMVLAEQMDSQEPVAHQTIPGEEEPELEKMDCETEISELLMVEQHSFVQEDNRQGQEPQETAFSRQRTQETPLQVEFSGTAEEIPQNIVVQGTNSIAGHLLMQQQKTLEFCGVNDQLKEPRCNKKVKKMKRKKPSCFEEPFAKKPRYLNSEKPKNGKRKDTSSNLCSKIFTLYFPQPALMYSTNLGNRFPKCHILSSTTASKRGATKLIEDIFIEREFVLHNKTKQVKVVAKKNGVRREGEKKKKNLRLPKRFVKIKGLFDRMLKRHKKCRFNALLKHHCKGMVDLSEEKEKQAEKPIGIQEKLVQVEKKQAGFQEKRVTIQEKVVGILQIRPSQDERKGREEDKNQSKDGKIQENHEKKSNLENKSVPGRXVSESKQEKYDRAVQNFIPRFQVVRFVVAVCNRVIPKELWGSPQNKKAFYNNLKSLINLNKGEKYSLGQMVNGIKIRECKWLRCDAGRDKGIPLSESEKQREVLYKWVWWLVRRYIMVILKSFFYITENAGQTREIYFYRKPVWKIINDFGVASMKSELLKPLSKDEATEILSSNSSLGYSYMRFLPKAQNVRPIINMKHQHSSNANNKIQASINSRLRNLFEIIKFEKSREPPRSESTVFGNDGVYQALRAFHLKRKGRHDERSLYMVHVDINKCFDSIPLHKLYGIMEGVFEEEEYIVRRFVAIKSVNNMARKVFSKKVDGGEDCRSFKQFLEDMIQENNLNNVIFVDQVYYNCEDRENILALLRRHLFDNIVKIGSKFYKQVQGIAQGSILSTYLCSYFYSHMEKRYLQQVIQDELSLLMRWVDDFLFLSPNRALADTFLRTMHAGIPDYGCQITSRKTLANYETTDSDGIPVRCVGRDEPFPWCGFLIHPDSLETKLDFSRYEDKHRNTVLRNLHYHPGRSLLEKLXYSLLNKSHPLLLDTEINSRSTVWSNIFEAFFWSACKFYNYCRGFPKGRKIEENPSLCMRVILALPLFFCAQAELKFKKLSLKELKKPSRRHVFGVSKNEVEWLCLQAYIKYLKKKPSFKIVVKALRKRIPKVLVKNPVMAPNFFSCHLPMPRGHVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV66</accession>
    <name>A0A6P8IV66_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MKRN2 opposite strand protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570964.1">
        <property type="nucleotide sequence ID" value="XM_031715104.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IV66">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="116305244"/>
    <dbReference type="KEGG" id="aten:116305244"/>
    <dbReference type="InParanoid" id="A0A6P8IV66"/>
    <dbReference type="OrthoDB" id="10065749at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032016">
        <property type="entry name" value="MKRN2OS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053921">
        <property type="entry name" value="MKRN2OS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053922">
        <property type="entry name" value="MKRN2OS-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33963">
        <property type="entry name" value="MKRN2 OPPOSITE STRAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33963:SF2">
        <property type="entry name" value="MKRN2 OPPOSITE STRAND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16044">
        <property type="entry name" value="DUF4796_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22795">
        <property type="entry name" value="DUF4796_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MKRN2 opposite strand protein-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="MKRN2 opposite strand protein-like C-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570964.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24764" checksum="BD7A74CD7F5E38AD" modified="2020-12-02" version="1">MISSKKERIMCMQHCSSSLSIFFVDFPPRCPVCSVELKSCQLIIPPFCLPCPFSSSHDPSSRCSVLIRPTKGDFLRDYVNGDNLHIGIANSRGFIYNYDERGLVMDDNNWDQCARLDITCHEAGIWDSVLDASCHSDCWXLARYDEDSYNCYTYVLKMLSNIQNQNCNQDYKEYDKEEFCRLYIIPVTTRIAKYIDLFRNIDTKGTVVQQKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV77</accession>
    <name>A0A6P8IV77_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="6">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA 3'-5' helicase BLM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031571181.1">
        <property type="nucleotide sequence ID" value="XM_031715321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IV77"/>
    <dbReference type="GeneID" id="116305424"/>
    <dbReference type="KEGG" id="aten:116305424"/>
    <dbReference type="InParanoid" id="A0A6P8IV77"/>
    <dbReference type="OrthoDB" id="5959447at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571181.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="38376" checksum="F933ED948FBDEF1F" modified="2020-12-02" version="1">MERTIVYCKSIKDCGRLFKLFKSELGSDSYFPQGCQKESQNMLFGMFHHNTLDKHKDRILNSFHNEDGVCRLVFVTNALGMGINFPNVRTVINYGPPREVEELVQEVGRAGRDGQPALAVLLYHGRHLRKCEDTIIEYCSNSDDCLRKHLASQFEQIQELIFECGTHDCCLNCHQKCYCEEKCQIPIPCFDDITSNVEKKMRIRKVSKEDKTLLRELLMEHKDSQQSGLVTYLHPECTAGFSNSLVKAVIKQCNKIFTLEGIVSNLPVFKRSHAVDLLNMLNDVFEDIDLKQLEIAVETAPECLERDYDLTYNQCYEYESSSNSSEEEEECYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW80</accession>
    <name>A0A6P8IW80_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M-phase phosphoprotein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570353.1">
        <property type="nucleotide sequence ID" value="XM_031714493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW80"/>
    <dbReference type="FunCoup" id="A0A6P8IW80">
        <property type="interactions" value="2088"/>
    </dbReference>
    <dbReference type="GeneID" id="116304719"/>
    <dbReference type="KEGG" id="aten:116304719"/>
    <dbReference type="InParanoid" id="A0A6P8IW80"/>
    <dbReference type="OrthoDB" id="20403at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570353.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20346" checksum="E48021ED3035B814" modified="2020-12-02" version="1">MEEDRQPKLALSKNLKEMKFMQRRAESDYRKQLEEERRRKIDEAHWVLNTKTGESERVEIEPSYVKCEQLYSNGRMSFKNFNPTVEKTFKQMKAEDEEILSEEREREATVSDEEMARRYDTLVGTIGKKYSNKRDRSTVIVDDDNDDDEDRDISHSTSKKKFKGGFMKPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWI6</accession>
    <name>A0A6P8IWI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LOW QUALITY PROTEIN: uncharacterized protein LOC116305612</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116305612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571417.1">
        <property type="nucleotide sequence ID" value="XM_031715557.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305612"/>
    <dbReference type="KEGG" id="aten:116305612"/>
    <dbReference type="InParanoid" id="A0A6P8IWI6"/>
    <dbReference type="OrthoDB" id="5982522at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF12">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="191"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031571417.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51641" checksum="A059DB149B04EC27" modified="2020-12-02" version="1">MDEIFPGLQDIFDYEMQDFTLKLEKVPYENPQQVQTDQKKGRFAELSEKDLNSLIENRLSAKTKKATNWAISTFKSKXNWCREKKIQTPLEKMTIGHLDLNLQRFYAEARTKTGEDYSKSTLLDFRHGLERYLNQPPLNRGLKISXDPRFQKSNQILDAQIVCLKKKKKQSTTHKPPIEEEDLVKLKASPVISLATPLSLLXNVWFHVVLYFCRRGREGQRELSVTSFKSEKDPSGRNFFTLSHDEVSKNHPGGVKDHESFENDARMYETDHQHDGFKALKFYLSKVXPNCCSFFQYPRRNWSANDDIWFEARPIGQNKLGNMIKDISKAAGLSKTYTNHSVRATSITVWSNNGVPNRHIMAISGHRSEQSLVHYNSRPSTSQLYNCSAVLSKAMEKPKEEAVQSTLITSSPRISLVGVQSLSSLGQHGFFNSFTIQNLQIFIGHANKTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXD2</accession>
    <name>A0A6P8IXD2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Activated CDC42 kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116304941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570605.1">
        <property type="nucleotide sequence ID" value="XM_031714745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXD2"/>
    <dbReference type="GeneID" id="116304941"/>
    <dbReference type="KEGG" id="aten:116304941"/>
    <dbReference type="InParanoid" id="A0A6P8IXD2"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="42"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570605.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32788" checksum="01C85C9AC639A575" modified="2020-12-02" version="1">MPNKKRPSKQKGKLKFLGDEEEPKSLRNNTVHPTCVIAGEDIVEHAVIGEGFYATVKVGSWTRHDKKEEKVAIKCIKEEVVRDHLGEILTEANNMVKLEHDNVIKLYGICLVTRENEQCKVKLVTEYAPFGPLVAVIQDKDEEQRRFFCQVTKLLEFASQIAKGMQYLHSKNLIHFDLAARNVLVVAPNKVRISDFGLARVLCQDEKKILLEKPIAVAWCAPELFKNQLATKGCDVWSYGVLLWELLSFGEKPWKDLSIEQVRRHYTSYKATYFFIFEDQGGHVGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZR2</accession>
    <name>A0A6P8IZR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305463</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571235.1">
        <property type="nucleotide sequence ID" value="XM_031715375.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305463"/>
    <dbReference type="KEGG" id="aten:116305463"/>
    <dbReference type="InParanoid" id="A0A6P8IZR2"/>
    <dbReference type="OrthoDB" id="6357832at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571235.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="74348" checksum="819C5EEBDC6C27C5" modified="2020-12-02" version="1">MVLSSEIQIRRSCAYKPLRKPSAPISKTSNRANFSEELVRGFESKILLLDEDCFKTAGDAIEKEILSSLNEGTLTTITCLQLFLDTAWKDRNRTPIIAEIFHNIAQDHDDESTTGLTVLLEKSCNDLLNILTCLGKPEVNDIHIVTLLSNLYRLETLPEEHREGVESFLVDIAKAFWPYFVPQKREVWDNELVSDAICDVFHTVGKVLEIKCPVNMERTFNKITTMLFSANVISEYTRLRLLEVKENRATGWILPDSARDYYKAAFLKLPRNRHNSSPRPASPSSPSSSVEDVFITSAENSPPTTPTTETKREFLKHDKYEVTVCGNWTTVSEKPRHPFVIRIKPKPLPEQNNNITSVTNNSTARINSNPTSKQPEDEKLQNISEQECTDHLEIGKVSTPKIKGFQDQSCGFGSPNGSDNSNLQAGKDFQEGRKSYENWSESHSPSFTESPFNRHNSFDNESSSIRQRLSSTGEMNHQRRSPFNRNGGLHRSHSESSTGEASYFRQGQSPNGCDSTGFGHPDGERLHSWRPNYHRQTSNDSIGESSYSRHGLSPNGCESTGFGHPDGSRFSSWTPNYQRQTSYNRWRSNLEFPVKEVLEGEDIDTSSRLYLLSFATRPAALERPADLTLTPEVEXEKEWLKCLILDEPNTVLDRFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J115</accession>
    <name>A0A6P8J115_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin subfamily A member 6-like protein 22 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573179.1">
        <property type="nucleotide sequence ID" value="XM_031717319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J115"/>
    <dbReference type="GeneID" id="116307171"/>
    <dbReference type="KEGG" id="aten:116307171"/>
    <dbReference type="InParanoid" id="A0A6P8J115"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573179.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39338" checksum="7DD3F07A72F8B6C3" modified="2020-12-02" version="1">MADKGKTSYVGRLKDDIKKNERIQIEMEEKLRKLEEKLKDHDENCQTKINELEEEIKRLKGEIEKLKEENNTLQENIKELEMKTEDLEESNTFLEKQMKEIDDNAKKEIGELKTKLGNLDEKLKKSELSEDELIIRQLCSSVQENLSRIVLQGYFEEIQNKRTQDMENYISTQIEDEDEQNKARLRWEELKKEINWNEFWIKQLKPVKKRGNETAHPPLTEKVIDAAKNKLKRREKLGKHNVKAVDQLKDIWTQTNRKLPQGNMVVVDGESSHRTISNGQEQGGPRRVSTTRQKHEDVRTPNGTYASEAAGGRGGDFNPKKANGRQSFSRYAILGKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1N3</accession>
    <name>A0A6P8J1N3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acidic mammalian chitinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573816.1">
        <property type="nucleotide sequence ID" value="XM_031717956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1N3"/>
    <dbReference type="FunCoup" id="A0A6P8J1N3">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="GeneID" id="116307680"/>
    <dbReference type="KEGG" id="aten:116307680"/>
    <dbReference type="InParanoid" id="A0A6P8J1N3"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000356">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028326828" evidence="7">
        <location>
            <begin position="18"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573816.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="49992" checksum="58885207A3310ACA" modified="2020-12-02" version="1">MRLLIVLLLAVISYATGSYVRVCYHTNWSQYRPGAGRYFPENIDPFLCTHLVYSFAKIAQDNTLAMFEWNDDKLYPRFNNLKKKNPALKTLLAVGGWNHENYNSPFSRMVRTAATRKVFIDSSIKLLRTWGFDGFDLDWEYPGVKDRGGSPPEDKQRFTVLCQELLDAFKREAQETNRPRLLLTAAVAAGKGTIDKAYEVPKIAQILDLINLMAYDLRGKWESNTGHHTALVGPPGEILTVSFAVQYWIDKGAPANKIALGMGTYGRAFKLVNANDNGLGAPARGNPTKGQYTRESGFLAYYEICKMNLKRTSTEQSAVKAPYGYVNDQWVGYDDPSSLKLKVDQIIKAKGLAGAMFWALPLDDFSGNFCGQGPYPLMNAVKRYLGGGGPSPPIGPTDPATQPPVTQPPVTQPPPPSGPCKAIPPYDTQPGMNDWCNQMCALGNCPATHCVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J235</accession>
    <name>A0A6P8J235_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylserotonin O-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Hydroxyindole O-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116307473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031573604.1">
        <property type="nucleotide sequence ID" value="XM_031717744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J235"/>
    <dbReference type="FunCoup" id="A0A6P8J235">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="GeneID" id="116307473"/>
    <dbReference type="KEGG" id="aten:116307473"/>
    <dbReference type="InParanoid" id="A0A6P8J235"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017096">
        <property type="term" value="F:acetylserotonin O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000358">
        <property type="entry name" value="Acetylserotonin O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000146">
        <property type="entry name" value="Acetylserotonin O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="11">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="10">
        <location>
            <begin position="118"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031573604.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38745" checksum="95C00F0A59D92066" modified="2020-12-02" version="1">MASSGICSPVPQKVFDYIHGFCASQAIFTACELGIFDVVETPQPSQKIAEQISGDHDAVCRLLDALVSLELLVKHGDNPDEALYSNSSMGDCFRKSSPTYMYGYVMHVMKTNKPLTGNLTSAIREGQSQWQRTFNATSNDLFKNNYSSKEKLIHFQEGMRGSVKSATSIFATAFDLSRFPRLCDVGGGTGDVAYAMCMAYPNMKITVFDLPNVVEVSSHFKPPLKECPNQENVTFVGGDFFKPSLPPSDLYVLTHILHDWGPAECDAILDNVFNHLPSGGGVLLGERLIYDDRNGPMTPVYWSLIMRCISDGRESSGLDYKRLLEKHGFKDVQVKYTHSNLLDAVLAIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2E4</accession>
    <name>A0A6P8J2E4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain collagen C4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574146.1">
        <property type="nucleotide sequence ID" value="XM_031718286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307952"/>
    <dbReference type="KEGG" id="aten:116307952"/>
    <dbReference type="InParanoid" id="A0A6P8J2E4"/>
    <dbReference type="OrthoDB" id="6086925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027857678" evidence="2">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574146.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="31808" checksum="35EA1029D3B6814D" modified="2020-12-02" version="1">MGCTAALLVAMGLVMFCVAQMTDXQQQNVRKKAADPTKTPTTLSDVVNMLMNLEKRRPVKLKGGFRTLGRDGRDGPPGKPGKDGRDGRDGLPGPPGLKGEPGHQGVRGPPGPKSGGVQYVRXGRTXCPYNATLVYKGRIGGEYYDNKGGGANYVCLPETPKYGRYKDGFQSGGNIYGAEYEVSEFNPFTTSNLHDHEAPCAVCYVTTRSVKMMIPATYECPAGWTPEYNGYLMTAXHGHQXPFEFICVDEDAEAVPGTHANLDGALLYXVEGRCGSLPCLPYVEGRELTCAVCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J419</accession>
    <name>A0A6P8J419_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tropomyosin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572758.1">
        <property type="nucleotide sequence ID" value="XM_031716898.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306804"/>
    <dbReference type="KEGG" id="aten:116306804"/>
    <dbReference type="InParanoid" id="A0A6P8J419"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572758.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29106" checksum="32359AF2B77E3636" modified="2020-12-02" version="1">MASAEHLSKVKSKLSSMKERIDQTEDRELEAKEKLREAEARLEKALADVDSFKRRIQLVEIEAKRTKETLDIRTNELEEIKRRTKSEEDACKELEVTDRESDTKMSEMEDMLVEAIAXDKDAAIKLAENELKFKVTSNELEKANQRAGQLEERATMLENHLTGCVENMASLEEKDAAASEREIEGEEKIEFIQEQLKAMVYRYEEAERKAPPLENLIFQIMEDVDNFKQKRSEIETEMKAMGDLVEEVTGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J584</accession>
    <name>A0A6P8J584_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116306688</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572635.1">
        <property type="nucleotide sequence ID" value="XM_031716775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J584"/>
    <dbReference type="GeneID" id="116306688"/>
    <dbReference type="KEGG" id="aten:116306688"/>
    <dbReference type="InParanoid" id="A0A6P8J584"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572635.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45171" checksum="DDF455BB60579281" modified="2020-12-02" version="1">MFACLGKHYYRDACMVFLSHLKYWQDTNHPMLTEFFKMMPEFSEVVCELFFSVLSAHTKPHDTEEQVQSSAITVDLMEEEVPSIHDVYKVRPLDCYTHNLMPSTGPKFFALVEDATSFLKILFNKCLGEEGIPLEEAATFDKTTGLLSYQTKVFGLVPANLFPLPCSLPSCAVVCSICEGLLDGSIEYKSRIRLKCGHMFHQLCLVPNLGSIQLKALYKEELKSLCSMYNLNTIGTKAVLLERLNDSLTPAQKQMKITSCQGCTREDTSPSLRMFRHCCKNFILPDQESIRLPCSHIVHKLCKKSGSCTICTFLLRELTTTVCEKAKLTFTKEYVPKSGTSADDEQDSDEDTEDYSDIGPGLSEKQEKVVHYFGELAVKTKHNKEQRGSLPKLKIDKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5K1</accession>
    <name>A0A6P8J5K1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116308634 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116308634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574964.1">
        <property type="nucleotide sequence ID" value="XM_031719104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5K1"/>
    <dbReference type="GeneID" id="116308634"/>
    <dbReference type="KEGG" id="aten:116308634"/>
    <dbReference type="InParanoid" id="A0A6P8J5K1"/>
    <dbReference type="OrthoDB" id="10368623at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031574964.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19671" checksum="C22BA6921DBDB9F6" modified="2020-12-02" version="1">MDEEERNYCCLALLLLRVGNPCLRRYFKNQWNAAVKYIPWTDCAQNGADLLRMFKPLPYEKNAVRSGDTSQWDMSLLVKTLLYSRPPFVVAANLVAALKTLKEMRNKLCHSPIPRVEATDFQTSWRDGCHALSLFGATAGDFDKVEQGECDISDRSHPSCISFSTIYSHVVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6N1</accession>
    <name>A0A6P8J6N1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116309039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031575429.1">
        <property type="nucleotide sequence ID" value="XM_031719569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116309039"/>
    <dbReference type="KEGG" id="aten:116309039"/>
    <dbReference type="InParanoid" id="A0A6P8J6N1"/>
    <dbReference type="OrthoDB" id="5989193at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1770.10">
        <property type="entry name" value="TPR 1 domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="231"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031575429.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49493" checksum="D33C7823292CD849" modified="2020-12-02" version="1">MADGCLAFRQLYVELFGVCPFSECVTIASTCLRVFKSNFLEPETMGVVPPLGYRSRDVCSVQAKEWLYSLSIEGLEWAGSAQGEATILGAKVDGYDENRRVVYQFQGCYWHGCPTCFPSRGAPHAHLGISMSDVYEKTLRRTRELHGAGYKVVQMWGHVWDVQREQHQDPPKWIKDLDPIRPREAMFGGRTNAITLAARAKRGGEEREREEAQEEEEEDADLALTLVSDSVDKIRYIDVCSLYPYVMYDNFYPVGHPVVLYGKDIPPLDRCRHKLLYHWYGLIRCEVDPPKTLYFPVLSVIINHKLMFPLCLTCAQQENGEPCEHSPEERRLYGTWTTAEMERALEEGYKLHAVYEVWDYERVSGQLFKTYIRENLKLKLQASGWPQHCTPSETXAAFVRNVKREQNMDLEEDKMVFNPGLRSIAKLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCZ4</accession>
    <name>A0A6P8JCZ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574415.1">
        <property type="nucleotide sequence ID" value="XM_031718555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCZ4"/>
    <dbReference type="GeneID" id="116308173"/>
    <dbReference type="KEGG" id="aten:116308173"/>
    <dbReference type="InParanoid" id="A0A6P8JCZ4"/>
    <dbReference type="OrthoDB" id="10248487at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574415.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55149" checksum="6E884591D7A94CE5" modified="2020-12-02" version="1">MEYDLVIEASSLFLLNSAVKENPSLSNDNKTQVSPEVQGLCSSAVLDHSVFPKDVFSAETSFLTPDRVIEEIGVCGRGLSQPLKSDRNNNTKQESTRILDIIKYSPKFLRKKNSKQPCKNVSHYVEESNGGLQGASNQKFENHENPGTVSPKMGFRKTFQSSVNQKDTAVTEKMKTTATRNCKSATSDKEIPEFGPSKGRKNWRKVKAALKRMNDGGEQLKSMSLASSEENIQGVAGKLRINLSSETSIDDDDDDEEDIYQRLKAFLNSSDKKFKTPWSPRSPRLQLRSNKYSFWPKGAEAGGVPYAITPMVEEENGVNQFPVLKSKRYPLGMRRCSAPEPVLRREAEAFSFIKKGKDMKINSQKKSIKNKKANHGDPKPYDRVEHEVRQRMRLVMEKNLETLTEYCPEICGQLSSTISEEITKYLRSTDIFSEDVQKKCVCLVYIGAVKDDGIHAAVRCMWIPGEDRLVVFDYQNNSLYALAIVFTASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JGB6</accession>
    <name>A0A6P8JGB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fermitin family homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575330.1">
        <property type="nucleotide sequence ID" value="XM_031719470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JGB6"/>
    <dbReference type="FunCoup" id="A0A6P8JGB6">
        <property type="interactions" value="1403"/>
    </dbReference>
    <dbReference type="GeneID" id="116308957"/>
    <dbReference type="KEGG" id="aten:116308957"/>
    <dbReference type="InParanoid" id="A0A6P8JGB6"/>
    <dbReference type="OrthoDB" id="10057618at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030055">
        <property type="term" value="C:cell-substrate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13205">
        <property type="entry name" value="FERM_C_fermitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17095">
        <property type="entry name" value="FERM_F0_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17096">
        <property type="entry name" value="FERM_F1_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037843">
        <property type="entry name" value="Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040790">
        <property type="entry name" value="Kindlin_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160:SF13">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18124">
        <property type="entry name" value="Kindlin_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="380"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575330.1"/>
        </source>
    </evidence>
    <sequence length="684" mass="77711" checksum="5C108536CA6A42AA" modified="2020-12-02" version="1">MANTGGKKPFWNLSVYITSLSTEKPVEVNGETFVGKLMLDLVEGLDISADWSDHGLWWPQKRMWLLKPRLTLDTCGVQGDAKLHFTPIHKKIRVQLPDLQYVEVSTNFSIKVFGAVQELCNELGIRHPEELCLMKPNSRMLKEGKRSVRGKTKKRLSGSSLSSDDNLSQNSDDKQRGSKDSLTPTYGTIPKHGYTSNGSLSPGSTSPTPSSPAYSSLSPDGSFNTIDNTQLSTSPLIPSTEAVNMLYKPRTLQEKAYMNSGWLDSSKSLMEQEVREFDTLLLKFKYYTFFDLNPKVDDIRINQLYEQAKWSILTEEVECTEEEMMTFAAIQFQVKILSTSPQPNVTEDDDDIDAALNDLQATLEGSSLTNTPVKDNLTAVPEIKDYLNLIKQKAFGVKKKKHWFVFKDTILTMHKSQEESYGQPLQKTNLRGCEVTTDVNVHKDRYHIKLRLQDGEDLEIACQTETQYAKWMAAFRMASKGKTMADVTYNSEKAGIQAFLSMQHDKGESTPTSPGQIQIQPEDFVGPRMLRKYKPKQIAARILDAHTSLQKTSLVESKMLYIRKWQSLPEFGTSHFIVKFRSDKPSKKEEILGIAFNRIMKMDPSSREAIKTWRYSVMKSWNVNWETREMIVQCEGETIAFNCLSADIKSIHEFIGGYIFLSMRKDVNQPPSDELFFKLTGGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1H5</accession>
    <name>A0A6P8H1H5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dual specificity protein kinase splA-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549493.1">
        <property type="nucleotide sequence ID" value="XM_031693633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1H5"/>
    <dbReference type="FunCoup" id="A0A6P8H1H5">
        <property type="interactions" value="2288"/>
    </dbReference>
    <dbReference type="GeneID" id="116287024"/>
    <dbReference type="KEGG" id="aten:116287024"/>
    <dbReference type="InParanoid" id="A0A6P8H1H5"/>
    <dbReference type="OrthoDB" id="10055441at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF8">
        <property type="entry name" value="NUCLEAR FACTOR I, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="9">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549493.1"/>
        </source>
    </evidence>
    <sequence length="666" mass="73864" checksum="C2073C998A6FB02C" modified="2020-12-02" version="1">MVLSADHTPTADYFEMANPGVFDQQDEIHSFIEALLPHVKAFAYTWFNLQARKRKHYKKHEVRMTPAEEKRCKEELDAEAPEIKTKWASRLLGKLRKDINDECREEFVTAIAGAKPGSSCRCVISKHDQKGKMRRIDCLRQADKVWRLDLVMVILFRGIPLESTDGERLGKSEYCHHPGLCVLPNHITVTVRELDLYLTNFMCTREHKEDSDTRSGHGSPADQQARIQKLSRENNLVLSGVFTVPELYKCSKTPINYGGSNQGLVLSGFESPPYMPDTSLEQRFPQALNIHQRSDPFEMRYRKKSRTLSSISSVDEDLGDEEYVHSPSGFSPQTSGWPNEMDGSVVQSPVMPFPVKIKPEQNCGTYEMIGQQSNIQCCGMNEPQSPSMNSYNTQQQQQQQQQQQQGQQRPLISPDFNNNMSDAYLQAMTGQKNLGPMGNMHTQAQAFQFRIPGPMPTVGSAPSRTGQLATEYIQYLDRPRSSSVPTPRQMGMGPSAVIPPSSLSRAQSHGSSVNASVSSNNMGSTDQVVSSATRQSPVPSSPSSRSPTSGITLKTTLQIIQAAVSNSQTCAPTLNNQSQAYSYGNYNSNQVSPASMSPNIPMGMAQRFRLPTPPPHLSGSNPTDDDAGDQYQQIVQTLNGMTSDVTMLENERNYFQISNSVSGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2R4</accession>
    <name>A0A6P8H2R4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-acetylglucosamine-6-sulfatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549888.1">
        <property type="nucleotide sequence ID" value="XM_031694028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2R4"/>
    <dbReference type="FunCoup" id="A0A6P8H2R4">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="GeneID" id="116287356"/>
    <dbReference type="KEGG" id="aten:116287356"/>
    <dbReference type="InParanoid" id="A0A6P8H2R4"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012251">
        <property type="entry name" value="GlcNAc_6-SO4ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036666">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028199787" evidence="7">
        <location>
            <begin position="25"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036666-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549888.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59082" checksum="643AF2C13C00267F" modified="2020-12-02" version="1">MKKSTFLVLVISCLFAYGRNSVTAKKPNIVLILTDDQDTILEGMSPMIKTKKLIQEKGISFENMFVTSPLCCPSRSSILTGMYTHNHHAINNSVEGNCASNKWQRESEKQTMNTFLKAMGYGTLFAGKYLNQYGINETGGPQHVPPGWDKWYGLVGNSKYYKYTLSVNGKPEVHESDYKKDYLTDVISRYATSFIQSRASSSSPFFMFLSTPACHAPFTPAPQYKDMFNTSKAPRTPSFDVAGGKTKHWLIRQTPHPMAKSSIDFLDNAFRNRLRTLLSVDDLVEQVVTMLDKTKQLQNTFIIFTSDNGYHLGQFSLPVDKRQLYEFDIRVPFLIRGPGLKANKTLQSPILNIDIAPTIIELAGGQAPKTMDGRSIVPLLNDSNVEESQEDNKVKVHDAAVKWREDFLVQHSGEGKMKVEGCPKLEPGFESCEPDCVCEDTWNNTYSCLRKLSSSQNFMFCEFRDKEVFMEYYDMTKDPHQLSNIAKKVNPRVLVPLHKRLEALTMCAGDTCRQEDDNDDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2W3</accession>
    <name>A0A6P8H2W3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coadhesin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549948.1">
        <property type="nucleotide sequence ID" value="XM_031694088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287412"/>
    <dbReference type="KEGG" id="aten:116287412"/>
    <dbReference type="InParanoid" id="A0A6P8H2W3"/>
    <dbReference type="OrthoDB" id="5985007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052229">
        <property type="entry name" value="Collagen-VI/PIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22588:SF3">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028474861" evidence="1">
        <location>
            <begin position="20"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="186"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="370"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="560"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549948.1"/>
        </source>
    </evidence>
    <sequence length="866" mass="96103" checksum="C69B8203F7EB403A" modified="2020-12-02" version="1">MKLIRIFIVNVFLLHTVSTEFDLNEVGCGSLLDNYLLDNSSISFSATSGDPGRPLLSGEPWKPTTISFRNSLTVDLGANYSVSQVVWSGDPATXEQTNQMAIQYSYDGITYDCRRKRLAPASCNPYYGNYPPPAPSQAINVVNLGSVVTARYFRFVPIEPDPGVKPGSHNLRIDVNGCVKGIPDIDLVFLFSSTSTILADATAAFTFMKNTAKEFVTQYGKTYIRYGLIVFGITVNDVFNFQTTASMDKATLKTSIDGSNNIAGSSDLKAALGNAKAMLQGPGSRPNARKIVVVMMDTGSAQSQNELELAAKNLRDIEALVIGIGIGRQIPVQQLEWITLNRYYVMLFPWTGSYRHLCFGIAARCFKESDITFAIGAGSTNSAALFKLMKDTMGAIVLKYGMRTIHYSIVTYGLGSASPSVVRSFTSTGSLSSSDLKNAIDSLTYPGGSGTIATDAALNRCQSSFNDPSVRRSAERDVVLMTDKSSSISTATLRSLSYXLGASGLRIIPVGIGNNIDRNQLLLMSSNSEDVIHVTEVETANALELKVMHNVYRLYMLNYDMTFIMYAFSSQSSSYYSYMQNVIRTILQRYGYGRCRYTFIVYGGSSVMYYRFDSKAFPNLEMLLRAFARIPRAIGGSATNLSRAFEHAKANFQSDSRSDAWKVLVLMMDRKTGMNEAALRSMTTSLEEMGVFIIPVGMGREIDIVEYYYFTAYRDFVTFSSDYTSISYLNIGENIMNRVVRFEYVHMLFVINAGSVNSNVTYQLMKNCMLKMIRKYGVYRFRYSVIIYGSSFTKHVEFNTNFPYRDALINIVNGLVSQSGSSNNFFSGKSIPVLERLSLSGTPTVLPTPTQYKMRLNVQVVTFYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA79</accession>
    <name>A0A6P8HA79_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Syntaxin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116289674</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552486.1">
        <property type="nucleotide sequence ID" value="XM_031696626.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HA79">
        <property type="interactions" value="1518"/>
    </dbReference>
    <dbReference type="GeneID" id="116289674"/>
    <dbReference type="KEGG" id="aten:116289674"/>
    <dbReference type="InParanoid" id="A0A6P8HA79"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000022">
        <property type="entry name" value="Syntaxin 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000011">
        <property type="entry name" value="Syntaxin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF424">
        <property type="entry name" value="SYNTAXIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552486.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34239" checksum="3AE97FDE31389B6C" modified="2020-12-02" version="1">MKDRLDFLSLDDNFKDEESYGMDDSHQINMEGGFMDDFFTQAASIRQNIEKIIEDVESVKKAHSSILSAAVQDKENKDKMEAHMADIQRTANRVRSNLKEMELQXKEDEKKIAAGHSNVADIRIKRCQHATLSRKFIEVMSEYNTTQTGYREKCKARIQRQLEITGKVKTSEEVEEMLESDDPVIFTSNIVIETQQAKQALGDIEARHRDIITLEKSIMELHEMFQDMYMLVESQGEMIDRIEYNVNQAQDYVQSAKTETKKALKYQGKARRKKIICGVIIFIFLAIIIAIVVSELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAI7</accession>
    <name>A0A6P8HAI7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded DNA-binding protein, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552158.1">
        <property type="nucleotide sequence ID" value="XM_031696298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAI7"/>
    <dbReference type="FunCoup" id="A0A6P8HAI7">
        <property type="interactions" value="1875"/>
    </dbReference>
    <dbReference type="GeneID" id="116289394"/>
    <dbReference type="KEGG" id="aten:116289394"/>
    <dbReference type="InParanoid" id="A0A6P8HAI7"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552158.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16853" checksum="FA55C89542A5FE0D" modified="2020-12-02" version="1">MFARRSLLQIQRMVARCEGPVGDLQRGGKCLNSVQLIGYTGGDPVRGGTETHPLTRFSLATTKYYPTRDDKIESKTSWHSITVFKPFLQDKVNSYVRKGTRLFVQGSIDYNSYVDQEGQKKYITSIIPNDIIILGRSQSNLEGEEDPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC29</accession>
    <name>A0A6P8HC29_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291002 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553984.1">
        <property type="nucleotide sequence ID" value="XM_031698124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291002"/>
    <dbReference type="KEGG" id="aten:116291002"/>
    <dbReference type="InParanoid" id="A0A6P8HC29"/>
    <dbReference type="OrthoDB" id="10351354at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028313118" evidence="1">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553984.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26503" checksum="5D4F0FE4E70728FF" modified="2020-12-02" version="1">MLTVKMRRCFIVVFLCFXKTQIMASPLVIKTKLTDSSVLVPPLSNSSSLVYVKFSECCNEYPAACEDRDAFERIRNSLNHKLNKMNNLWVLVXKSLPNETIALRRRSKSRDTYKNLRVKRYPSMGSXKSKSFLKLKGKEGRKRKCLMTSMTVKQEGQLPLIECHQRQEILRIKRDLEESITLASDMYNDIATIGQECSQVRDLAKESVIRIKNCKEIAKEMIKMVHMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC64</accession>
    <name>A0A6P8HC64_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 74A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116287714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550262.1">
        <property type="nucleotide sequence ID" value="XM_031694402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC64"/>
    <dbReference type="GeneID" id="116287714"/>
    <dbReference type="KEGG" id="aten:116287714"/>
    <dbReference type="InParanoid" id="A0A6P8HC64"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031550262.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37304" checksum="CBDE1284754B1B31" modified="2020-12-02" version="1">MLRENCYLTDLNISSNGLRSQGCQAICEMLQTNTSLLKINLANNGFTDKDSKNIAEAMRGNDKVAWLDLSNNRFSENSGANFGQAIMSNDSVEHLDLSWNLLRKKVANEIANGLRTNCTIKTLNLSFNGFADEGAAALGEALKYNNTLTELDISNNRITNQGALCLAKGLEGNNTLETLKIGCNPIRTDGLLAIISATLSYCDSALTTLHCKDIYLDMQFTSLLHEVKKVKPEFKVFPSPRAGGRDPLKTLRTFITENKNKWFEICKNYDNESTNFVTRRSFADVIKKTGLKFEMDEITRLLSQLDPTKQGLIHYRHSRLGFDFPTKPTPERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCN7</accession>
    <name>A0A6P8HCN7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290011</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552838.1">
        <property type="nucleotide sequence ID" value="XM_031696978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCN7"/>
    <dbReference type="FunCoup" id="A0A6P8HCN7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="GeneID" id="116290011"/>
    <dbReference type="KEGG" id="aten:116290011"/>
    <dbReference type="InParanoid" id="A0A6P8HCN7"/>
    <dbReference type="OrthoDB" id="10383957at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552838.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39998" checksum="E03CB18E19DB287B" modified="2020-12-02" version="1">MEVEGTDFDPLTEEGQVDINDEEFDAWTQGAETDPLIYDAALENKYGSRWKSFKAALNRMWQSKNRGSPVPEYLELQNIDEQGATARETVEWATQELRMRYPNFEVDDIRLTERGNKVLISVRDMRYPDANRWTKPQLLFDDSGSVKVNVARLRGFKEATRSDLERLKTLNERVALERRAEGLQETLEEREADYMRQNQLLADAQKRELDDKNQLIVQMREQRDKALRDRDQAQRAFELALRDLDMSKEEAKNLHITIAGSLEERRQLVAEINAKEGQLRQMAQTIEDLERNIAEKREIINDQTRPEEEREAAQKEAETLQKPEAHVGVAVRTNANAAYYQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCQ4</accession>
    <name>A0A6P8HCQ4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein DPCD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPCD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552858.1">
        <property type="nucleotide sequence ID" value="XM_031696998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCQ4"/>
    <dbReference type="FunCoup" id="A0A6P8HCQ4">
        <property type="interactions" value="1349"/>
    </dbReference>
    <dbReference type="GeneID" id="116289997"/>
    <dbReference type="KEGG" id="aten:116289997"/>
    <dbReference type="InParanoid" id="A0A6P8HCQ4"/>
    <dbReference type="OrthoDB" id="10256139at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026224">
        <property type="entry name" value="DPCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921:SF1">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14913">
        <property type="entry name" value="DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02065">
        <property type="entry name" value="PROTEINDPCD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552858.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23691" checksum="2C9578598D525813" modified="2020-12-02" version="1">MAAAMQKFPWLETLKNARKTNLVQDGKRKVHYTFPDHTEMVEEYALSSGDLIVRKFKKRSTLGKEGKWEYEVGEDLRPMNADSEHIMESVTNPIATRKDTTKAFQWRIRNLPYPLDVYNITINEEKTAVVVRTTNKKYYKKFSIPDMERAKLPLEQKSLSFAHANNTLIITYQKPPLILEQEKLIRQELAKNKTGDGDLECKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDR3</accession>
    <name>A0A6P8HDR3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase family AAA domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553826.1">
        <property type="nucleotide sequence ID" value="XM_031697966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDR3"/>
    <dbReference type="FunCoup" id="A0A6P8HDR3">
        <property type="interactions" value="1483"/>
    </dbReference>
    <dbReference type="GeneID" id="116290853"/>
    <dbReference type="KEGG" id="aten:116290853"/>
    <dbReference type="InParanoid" id="A0A6P8HDR3"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19520">
        <property type="entry name" value="RecA-like_ATAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="117"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553826.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39421" checksum="9BCE5FBB5C6A17C4" modified="2020-12-02" version="1">MPDQKIRYIGAALQALLIGTLTYYGVKWIMEAFDPTRKSRLAAQKQAEKLLKKIGVEGVKLSEYELAIAADLVDPLSLPVEWTQIGGLQDTIQEVKETVILPIRQRDIFEGSQLLAPPKGVLIYGPPGCGKTMIAKATAKEAGCRFLNLQVSSLTDKWYGESQKLAAAVFSLAIKLQPCIIFIDEIDSFLRARDKTDHEATAMMKAQFMSLWDGLLTDRDCQVIIMGATNRPQDVDKAILRRMPASFHVGLPNEKQREEILRIILGHENVDDEVFLNLNELASITNGFSGSDLREVCRVAAMSCVRDYLKDRRDESGDNGSETLVQTMLRPINMNDLNKSALQYSSSVALKTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEF5</accession>
    <name>A0A6P8HEF5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553398.1">
        <property type="nucleotide sequence ID" value="XM_031697538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290497"/>
    <dbReference type="KEGG" id="aten:116290497"/>
    <dbReference type="InParanoid" id="A0A6P8HEF5"/>
    <dbReference type="OrthoDB" id="5986166at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553398.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="48239" checksum="632D89075543E49F" modified="2020-12-02" version="1">METLAKLDKFIEGKLKLLAFTSEDTARIVQEGDVKAMDRQAKALERSIDKIHEIKLQIQEIKIEGDWEPNEVRKWTEELEAKLSKYEKEFKTIKNEVTEVESKEKEKIEQEKRQRVFEDELKLQEVKLQRQFEMEKQYKEVTDSSSKPGSFSRAKLPKLVITPFQGTHLDWMRFXSQFETEIDKSEVSQVTKFSYLKELIIPKVRGLIDGLPYTTEGYERAKSVLKSKYGKPSEVSNAHMQCIISLPVIPGNGPSKIHEFYENLVAHVQVLETMGKLKEINGYVRLTLDKLPGVRADLVRLDDNWQEWGFPQLVESLHKWCERNPITFDRKAPIPTPEHGLRKSPQKRERVFQTKEETSKIITCVYCESGQHKSVDCDQVKGVQERKKSLAAKKLCFNCTGAKHRAADCRSKHKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFQ7</accession>
    <name>A0A6P8HFQ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116290842</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553813.1">
        <property type="nucleotide sequence ID" value="XM_031697953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFQ7"/>
    <dbReference type="GeneID" id="116290842"/>
    <dbReference type="KEGG" id="aten:116290842"/>
    <dbReference type="InParanoid" id="A0A6P8HFQ7"/>
    <dbReference type="OrthoDB" id="10060424at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028139493" evidence="4">
        <location>
            <begin position="21"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="92"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553813.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="50016" checksum="B888E8CBED0DF60A" modified="2020-12-02" version="1">MFTILPGILVALLYLGVSQGAMPSATKSKYETYLKEFDNQRGQNPGNAQFEANKKGAILFMKSKFEAAGLTVHLQNFSSTDTNNGKAVNGTNLIAVLPGQAYKTAQDEVVVLAAHVDTYGTGAGGVNNDGTGLVGLLAIAEDLAGSKKCTLKNSIIFAAFDLSETGGSYTFCNRSCGSVEFLKNKATYIGSGKIKLAMVMDCIGSFDKSDKSQVFSQSMEKNFHNIVLEEALTDYWGDFLAITGRSDDGVYLQEFERFYKANKVQHDFRVLAFQWNIKGVPTSQNRSNLISGFKGGDHMSFWDADINTILLTDTCYNRGYMKDTCKDDKTCDTISKLSATRYEFMYSAVYSAMRVTKNLTCTGACAMCSPYADCKNNTCICRTGFTGNGVTCTAIPCASCSPYAVCQNDVCVCKAGYTGDGNTCKKVNSGSSLASPHQLLISTFVLLSLVVLLSNAFLYKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFR6</accession>
    <name>A0A6P8HFR6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Trace amine-associated receptor 7h-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116288742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551425.1">
        <property type="nucleotide sequence ID" value="XM_031695565.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551427.1">
        <property type="nucleotide sequence ID" value="XM_031695567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFR6"/>
    <dbReference type="GeneID" id="116288742"/>
    <dbReference type="KEGG" id="aten:116288742"/>
    <dbReference type="OrthoDB" id="5954966at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="58"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551427.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39163" checksum="FFBC50793EB7A0FC" modified="2020-12-02" version="1">MSEFRLELRQTPNETLATEPVSSCPFVQSNLLYLDYLREVYIVNCILNAIFSLVAVFFNGVIFVSIRRTPSLHDPSHLLISILACTDLGVGLIEQPIYVLNKAAELNRLGKISCVTGAMTNMLAGLLAGMSFLTMTFISIDRFLALHLHLRYKAIVTKSLVLKATFVSFISFSLCVSFYPWLPSVPVYGGITIIIICLMVSTILYCRIYKIVRKHHLQIRNSAPKQQRHESERIVLKKYWKSVVGFVVVHLVMVLCYLPYAIALGMRAVSGITKEYKLILNVTTTIIYLNSSMNPLVFCWRIREVRNAVVKTLKQLFRKQSESSQTSRVQVNGTSNHAYVISMPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGU9</accession>
    <name>A0A6P8HGU9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase/endoribonuclease IRE1a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116289040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551780.1">
        <property type="nucleotide sequence ID" value="XM_031695920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGU9"/>
    <dbReference type="FunCoup" id="A0A6P8HGU9">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="GeneID" id="116289040"/>
    <dbReference type="KEGG" id="aten:116289040"/>
    <dbReference type="InParanoid" id="A0A6P8HGU9"/>
    <dbReference type="OrthoDB" id="6331463at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="261"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="5">
        <location>
            <begin position="509"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031551780.1"/>
        </source>
    </evidence>
    <sequence length="640" mass="72432" checksum="F06B827D6318ED34" modified="2020-12-02" version="1">MCRTWTAVELLLDAGARPGVTDSSGCTPLLAAVKRNMCLKKDSKCFYPDVDQTPNEFWEEVLNRKLDPWTADEEGNSVLSILVKKEAECLAKALIEVACELNCVQSDAIGVPLLITICKDKSTDKEWKTNFVEILLKSRIGLVSKTPSDSNDTPLHFSCRNILKLAKLPDSSVETSVHWKIVQYLLLCGADINASGEAGESCLALSENCPVLKDLLSAPVDHSELPLVLENWTPSSQSHAQKLNLVGRLVKCRQVRSIYLYSEALDEDKGTDGFVFAGIVQDGREVAVKRFDKSRIAPEKTPESILVLSKKQCEQIVQYYFCLDEGNFHYIAFELMEENLEHYFDMASSAGNSTKLCKDLLIGLKCLHSQGIVHGNINPRTVFYQANPSLCLKIGNCKTSSSRIGWVATEVLKDETSFSKQSDIFSCGLVLHYLLSGKKHPFAPADPVMRTPQEILSKTHKNITNGNIVKIDDSLSPEATHLVHLMLDSDPSHRPSAGEALVHPFFWEKKTKKAFLNVVGNEPEFEVGNRYPLTLFEYELQELFSVIVSSTKWNDPLKYGQISATRRRRNYNFGSIADLIRFIRNTYQHIHEQEASIQDWWNKYYIFDYFPRLIIEIYKKVKVYNLHKSRPQIQSFFIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGZ3</accession>
    <name>A0A6P8HGZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rab11 family-interacting protein 4A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554228.1">
        <property type="nucleotide sequence ID" value="XM_031698368.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HGZ3">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="GeneID" id="116291226"/>
    <dbReference type="KEGG" id="aten:116291226"/>
    <dbReference type="InParanoid" id="A0A6P8HGZ3"/>
    <dbReference type="OrthoDB" id="418358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="FIP-RBD" evidence="11">
        <location>
            <begin position="493"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="298"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554228.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63629" checksum="6BE0F13FFE2E5B2E" modified="2020-12-02" version="1">MEAIASKLKPIFDACDENGDGFVKTRDLIKLSGLGSQQSNEEIKTLLHKLDPDGVGKITFQDFCRRFHDSLGADGEHLTFNEGEKRGSQDSDQLEDSCFEADSSYSTASTNDYNGDDDEAFQDVDPNNSSFRRNQKQYSTYPPPTEPRTKHRSHPPRLCIDNSFSDCTSEYQSEEGYEGFGESLSEESTLQGSQNLKELTTGLRCQLHKSFSSNSLPYRRRISANHAALLSSPRIQYQSLSANVSRWNSMEDMYSSDGGGPMSDTEAGNNSFLYNEIRRLSSQVSVLLENHKLQTNKQHRFKEDNNDLSMRINALEDQLERQHESTGEKVQEESRKYKSALTKLEKENEEYLTTLTSKLRQAEEEIDKLKTFEPMLRKELDACQEDKRKLANQVDQLENALQSKTDEVENLKKKLELQAEVALEERHRHEEEVHTLXNQLVELEKFNSEAKVKLKDVLDLEHKSTELEERVQQLTRENNNLKSAKDELKVQLAQNGTYVMHEQTRSLADELQSANKDKVIDALRDQEEESRRLRGYLDSLLMIIMEHNPALLEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHW2</accession>
    <name>A0A6P8HHW2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase 4</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031555431.1">
        <property type="nucleotide sequence ID" value="XM_031699571.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HHW2">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="GeneID" id="116292284"/>
    <dbReference type="KEGG" id="aten:116292284"/>
    <dbReference type="InParanoid" id="A0A6P8HHW2"/>
    <dbReference type="OrthoDB" id="10009078at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22974">
        <property type="entry name" value="DD_ENO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047500">
        <property type="entry name" value="DD_ENO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF30">
        <property type="entry name" value="ENOLASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="11">
        <location>
            <begin position="61"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="10">
        <location>
            <begin position="294"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555431.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="67067" checksum="FE7BBE392BB9D6A1" modified="2020-12-02" version="1">MADTNGLYSLETKKQAVAYFKNNQVPQHVENLLNKMFKEQPEDIFGYMSEFFGGSSKXPLISKITSHEVLSSRGYPTVQLDLYCTIKGLSKFVTSITLLYDAAPLSTRTDDIKPKSPEPTKQQGKTPAESQPSAAPSENDFQVKTIDMDDLVQRITETLGPQLKDLDPXEQKAIDEILFNLVEEPKPESRPLSLQEQREDQDQSSEKPADESTIKHPKKSAGAINKKQSGMLDKKGGNKDSGIQLIPDMEEEHINIDYAILGVSMVTVMAAATLKSCSLFEHLVEISPKKEQNGFTMPIPVMTLLSSGKNASGKQNFIKEVLVLPKPGVAINKGIQQLTEIFHQMGRILSQKFGTFARCVXQDGSYSPVLDKPDTALDLVQDAVNGCGYTLGTDVDIILNCAASEYYDQDKLKYEIILNTFKSLDDVINMYCEXLDRYQGIVGIIDGVRSQDKEGWIKLNERIGEKCFIIGEELYKRNPGILSVGVTDKISSAGVLNMDQANTITELMDKASTLTDQGGLLMLSEGPVKDTVPLVVDVAIAVGARFIKLGGPMHLEHICKYRRLQQIEQELEKTSTLIQQEPHVFPVINVVENKDENNEQQPEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHZ2</accession>
    <name>A0A6P8HHZ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292784</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555999.1">
        <property type="nucleotide sequence ID" value="XM_031700139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHZ2"/>
    <dbReference type="GeneID" id="116292784"/>
    <dbReference type="KEGG" id="aten:116292784"/>
    <dbReference type="InParanoid" id="A0A6P8HHZ2"/>
    <dbReference type="OrthoDB" id="270568at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284:SF1">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555999.1"/>
        </source>
    </evidence>
    <sequence length="666" mass="74489" checksum="E430F226EEC98887" modified="2020-12-02" version="1">MVSPQSLDLSRIRPQDVAVVIGFLAAIFIFRAPDVYELKPVWRLDIEKTTGSEHNNILPLPIIVDLDSDGINELVVATQDGRIRVMTFPTKDFGGDLLPHLHIKVETSIKLDNVTSDYHPIPVTMATGCLKNRARHDECYKTIIVVTSDWSVLAYDHFLNLLWKTTVKVNSKTPMHFKEIAVLAIPQGQDGLVVVGGRTTDNKHHKQKLSHDHHVDAAPKETVEELARKSNTHSTMDPNKVSGESEHFSTFAFNGREGGIVWSHKPGDFAANVTAREHLLSSYHFKLALQPNQYHTGEEHWTKYLMSFLKTLPYRWHHPSDTKLFAARFVKGSRKTMSKAAKQSWFDIKAPNIDLFSSEEKKSEKDVQHNSIVVHNQHGVEVLKLDSGRPICRYTIPKESVSLGDINEDGHVDHVTTHFESRDDFPNSVPSCTAVVSSQSRTLFTGSICRTLSLFGGVFDGPADTKHGEEPLPVPPVIIHSPPHRSGILRHLMGHNLRRSRVGFDSVFLVSTGKVTSFGPHGELNWQVKVDGSWKDRVRADELSMTQENTRSFLPSMKPVAIESNQNQKALFIASWHHISLVSLVDGTLLASHTLPCQPVSPVVEGDFTNDGLTDVVVQCSDSYLGFSLDRHIGYMWTIIWVVSSMMAVAIALGLLRVFEEELFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI19</accession>
    <name>A0A6P8HI19_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurofilament heavy polypeptide-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555506.1">
        <property type="nucleotide sequence ID" value="XM_031699646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HI19"/>
    <dbReference type="GeneID" id="116292347"/>
    <dbReference type="KEGG" id="aten:116292347"/>
    <dbReference type="InParanoid" id="A0A6P8HI19"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555506.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15150" checksum="CE28F3D0AA28DC17" modified="2020-12-02" version="1">MPGKKGATKAAPKVDSQPEKTPEVHEEKAPEAEVEKEEPTVENVEERKNPEKKGRGRPKKTDSSEPSTKKPKQVKERNPPSRVSRRVANMKSGVTEPAVNAEQEPKNKDVSSKKAQAKAQEGKKELSASNGATEQAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIU3</accession>
    <name>A0A6P8HIU3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">G-protein coupled receptor GRL101-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116291724</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554792.1">
        <property type="nucleotide sequence ID" value="XM_031698932.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554793.1">
        <property type="nucleotide sequence ID" value="XM_031698933.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291724"/>
    <dbReference type="KEGG" id="aten:116291724"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554793.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42285" checksum="A9408E7181847171" modified="2020-12-02" version="1">MCCYATKSIQNLNCVSPGNEFSSCDDMLKNAVVKVCIWAEGVLATFGNLAVIAWWIFLSRKRPRTRRVKINSVQSLLFCHLALADLLMGVYLLLIGTYNEIXKGEYFLHDVEWRAGIKCKIAGAISTLSSEVSVMILVAITADRINTILFQFSGRRTNLKLAHFLCLLIWVAGFIMSFTPLLVPSYFNDKVSGFNFYGRSTVCLPLQLSKDRPPGWKYSVAVFIGFNGAAFFFILVXYIAILIKVXKSAQKVRSSSSSDSALGKRVLFVILTDFFCWMPVMILGVVSLVHDFNEPSVYIWVAVFVLPVNSAINPVLYTFSSSQTINSMKSIRRRLLKDKGGRLPPQQIGPVALPLKXLRICREKENPEQLAVEQELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJF3</accession>
    <name>A0A6P8HJF3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cleavage stimulation factor subunit 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116289919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552725.1">
        <property type="nucleotide sequence ID" value="XM_031696865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJF3"/>
    <dbReference type="FunCoup" id="A0A6P8HJF3">
        <property type="interactions" value="2995"/>
    </dbReference>
    <dbReference type="GeneID" id="116289919"/>
    <dbReference type="KEGG" id="aten:116289919"/>
    <dbReference type="InParanoid" id="A0A6P8HJF3"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000002">
        <property type="entry name" value="Cleavage stimulation factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="30"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="658"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031552725.1"/>
        </source>
    </evidence>
    <sequence length="717" mass="83122" checksum="7A3E14D9BAE03678" modified="2020-12-02" version="1">MSGAVKEEPGRQISEDQKETISFWSQSERGQKAEQRLVNHPYDLESWGVLIREAQNFPLETSKVLYERLVRRFPSSGRYWRLYIEQEMKHQNYERVEKLFQRCLIKVLNIELWKLYLTYVKETKSTLPNFREKMSQAYEFALDKIGLDFHSYQVWMDYIGFLKAGDAVGSYAENQKILTIRRVFQRAVTTPIINVEAIWREYNTFEQGINKTLAKKLIDDKTRDYMNARRMSKEFEALTRGLVRGAPSTPHLGTPEEVKQLQIWKKYIFWERSNPLWIDDTLLLTRRVMYAYEQCLQCMGFNPDIWCEAASYLETTSKQLAEKGDMQGSKLLSDEASNLYERAINGLMSLNMLLYFAYADFEEGRMKFQKSKEIYEKYIALEGVDPTLAYIQYMRFSRRAEGVKESRVVFKRGREDTRTNFHVFVGSALMEYYCGKDKSVAFKIFELGLKKYINEPEFVLAYVDFLRQLNDDNNTRVLFEKVLNTMPKEKSGEVWAKFLEFESTSGDLASILKVEKRRLQTFKEEFEQHETAVLVDRYKFLDLVPCSSLELKIMGYSGPLRQIGVISAPISCVDLQEEITEEKTVKFPLPDTTQMMPFKPTSGTVGFHSVPGGVFPIPPAAAHLMTLLPPPSCFLGPFVVVDELVRLISECTLPEHRPTSILPADSGLNGIDEENHTENTDRRGVKRAVGHDSDDESSPVIPPSHDIYRSRQQKRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJL7</accession>
    <name>A0A6P8HJL7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">T-box transcription factor TBX3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556031.1">
        <property type="nucleotide sequence ID" value="XM_031700171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJL7"/>
    <dbReference type="GeneID" id="116292814"/>
    <dbReference type="KEGG" id="aten:116292814"/>
    <dbReference type="InParanoid" id="A0A6P8HJL7"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20188">
        <property type="entry name" value="T-box_TBX2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000016">
        <property type="entry name" value="T-box transcription factor TBX2-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF181">
        <property type="entry name" value="OPTOMOTOR-BLIND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="141"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="T-box" evidence="6">
        <location>
            <begin position="146"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556031.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="64299" checksum="AB6FF12E21E58135" modified="2020-12-02" version="1">MTNQRRVLISSCEMLACSNAAVERTQQQYVSSSVACDNRERTVMAYYPYYPSRMRDFRVSSLLEGCSQFIPGMPGSNPSMPNNLNSNGPYSMYPPYHPQQLTKQPSHFGPATAIAANPHPSSQQIHMSGHESELENAELTLENKDLWMSFYKEKTEMVITKAGRRMFPPIKIRVTGLDPRAKYFFLLDIVPADDCRYKFHNCRWMVAGKADPELAKPLYIHPDSPSTGAQWMQKTISFHKMKLTNNIADKHGYTILNSMHKYQSRIHIVRGDDGYKYPVNSPFKTFTFEETPFIAVTAYQNEKITQLKIDNNPFAKGFREEGAGHRRRMERRRRTESGNDDDFNDDDEDRNSEDGADNLKDQLSINPKPENDAGSVSASSLVNEDKSLIPLKNTTTSSCNAAIVPSAGDIKPVVHQSNEEHQYGAYNHAQTVHLPEDTKHIHLTHESNEPGNVGGSLAIPPHLKAPTPRSFHMDMRFNPYSRPPYSLNSVPSGFIPTHAHTHGHVYPACTIPQAVFTGYQGSQGGYPAFSASQGYGFPAGISTPSMVGSLPTETRTSSELHNMDAHVTDHGGHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJP7</accession>
    <name>A0A6P8HJP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GDP-fucose transporter 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556604.1">
        <property type="nucleotide sequence ID" value="XM_031700744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJP7"/>
    <dbReference type="FunCoup" id="A0A6P8HJP7">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="GeneID" id="116293327"/>
    <dbReference type="KEGG" id="aten:116293327"/>
    <dbReference type="InParanoid" id="A0A6P8HJP7"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="12"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556604.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38668" checksum="F280550904814AD6" modified="2020-12-02" version="1">MTESILVKSFRISAVVSAYWCISISLVFLNKYLLSSPDLKLNAPLFITWFQCVITVVCLFLLSFLGEKYPWIDKFPDFIIDLSVAKQVLPLSVVFVGMITFNNLCLKNLGVSFYNVGRSLTTVFNVICTYTILGQMTSKKAIVACLVIICGFLLGVDQEGTSSHISHSGILFGILASLCVSLNAIYTKKIIPVVDNNIWRLQLYNNFNACFLFLPLMAILGEFQEIKTFSMIGSGYFWLIMSLGGIFGISIGYITGLQIKVTSPLTHNISGTAKACVQTIISVSYFDEVKTALWWMSNLFVLGGSFAYAYVRHTEMKASHAEEKKSTIKGEEELEAGTPLVSDDKISKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMG3</accession>
    <name>A0A6P8HMG3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293599</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556906.1">
        <property type="nucleotide sequence ID" value="XM_031701046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMG3"/>
    <dbReference type="GeneID" id="116293599"/>
    <dbReference type="KEGG" id="aten:116293599"/>
    <dbReference type="InParanoid" id="A0A6P8HMG3"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14727">
        <property type="entry name" value="ChanN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007314">
        <property type="entry name" value="Cofac_haem-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04187">
        <property type="entry name" value="Cofac_haem_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem-binding uptake Tiki superfamily ChaN" evidence="2">
        <location>
            <begin position="51"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556906.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34480" checksum="E40C9E27E651B4A5" modified="2020-12-02" version="1">MNFIRSMHEECMVSWTNMSSSLRSNLRRLSKSLSFLSVKGSSIKPCSFEHVMTRASTAKVVLFGEHHEQPSILKAQLCVLEGMASQAEEYFKQNQQKQKIFLVLEMFNFQQQFLLDAYRNYEISIRELEKNYEQDTEGFAIMEHYGYLLDTARSLGITVIAGFVPKSSCKEMVSDGKETTLKNIQNIGGPDKSFYVNGSEEHYRYFQGLISGKMDEVNDKYRKIFPAQILRDSFFAHSVNKIIQTSENNKVVGICGSGHIDHGFGIPERISRKIGPVLLLTSRMKEDKIDPNVADFIYQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN13</accession>
    <name>A0A6P8HN13_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Basement membrane-specific heparan sulfate proteoglycan core protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557759.1">
        <property type="nucleotide sequence ID" value="XM_031701899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294311"/>
    <dbReference type="KEGG" id="aten:116294311"/>
    <dbReference type="InParanoid" id="A0A6P8HN13"/>
    <dbReference type="OrthoDB" id="5961293at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="96"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="192"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="315"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="396"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="490"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031557759.1"/>
        </source>
    </evidence>
    <sequence length="714" mass="78581" checksum="3C72CF5B4D52AC5E" modified="2020-12-02" version="1">MITKLTALTSKSIXIDWQFTQSDKVNGPMVGFRITYGKEGGATNMIDIGDIRSYNLTSLEKNTNYKFNVSVRNTQYVGQPSVEAETRTLEDAPECAPVLKSVQSLSSNSVLLIWSSLQNLKCTNGVLRGYKVVYRETRNDSLPLQVXMVNIPSAITTVVPGLVQSVEYGFQVRAFTVKDGTLSNSLLATAQPVGNLSIVSEKMKPLVRAAIGEKVSIGCYATGARPISYNWLKKDAXMDSSSINVLHNFLLVEIKSELDFGVYLCNVTNNNGEAVSYKVRIEQLEICEQNGGSGNVTILRDKMTSIVKAALNXRVVLSCYATGSPPIRYIWTKDGSSINSSSIXVIGNTVIVDTKTAGDYGTYLCQATNGNQTASYEIKLKLSEICQKRHNSTQQGKLRILTNLMMQSVNVAIGNRVSIGCYATGVXPIRYTWTKEGIPVNPSAVIPNILVVEPKTSIDYGNYLCNVSKGNETDSYSIQVKPLEKCESCPESDRNQTQGNLQISREKMMPLIRARYXDKVSLGCYANGAPPIKYSWTKNNHSIVNSETIKVLENVVVVRPNTAADYGTFVCSVSNGRDTASYVIKLEHLDINGSGNASLSQSVQDFKTTYLPIILVLAIFIIILFIIIIVFLVRRRQRKDNDSTKPDSYMKMDEIIRSRNESARNVDESLPPIPTISTASASNTQTESHYDSIDCGYVNAAALTKXDETNVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP43</accession>
    <name>A0A6P8HP43_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116291393 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554420.1">
        <property type="nucleotide sequence ID" value="XM_031698560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HP43"/>
    <dbReference type="GeneID" id="116291393"/>
    <dbReference type="KEGG" id="aten:116291393"/>
    <dbReference type="InParanoid" id="A0A6P8HP43"/>
    <dbReference type="OrthoDB" id="6052143at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="3">
        <location>
            <begin position="597"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554420.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="79837" checksum="82E754679EA3A556" modified="2020-12-02" version="1">MGLYTIVFAMLGALALLLLVLCTLKSRWHREKPIKTSLGRKDLEDDGTRSWDEEGERFLSAHYPNWKQLEHTIMVPDIIQGGEPLTYARNENEESKVFDLLKKFGNETKQPMFVVHAHSFCELVSYHKTGIVDREKTKWIQGEHDFVIIHRQYGLIFLEVKSREKTKEVFKQAEKQIEKAKRSVENYLKKRFGKSKERNEALYTFPGFVVMPNCPRPKQSASHENGIFKEDCNVDSFKVWWEKVIAKPEKPQFESKVYEELVKKYVLFICSAPALNQQIDKTHDKIVKVLTPNQLKSWYKTLPEQWISGPAGSGKTVLLIEKVKQIAEDITVGEHQQERILVLCCSVPLSIHLNNEISDWFNSEFPSKTCPVHVKTYDSFINEIEKESVTVRRGQKNLFLRRRLEVETKLIERLPEEFEHRYEHIFVDEGQDMFLDKWPVFLKKLHRTPVASRRYYFWIMYDSNQHLQRKEINRSFLDKITRNTSQLTEVLRNTKNIFSLTNKYYKGIYEGEISLGHQIIGLEVKYDNQLSKKNLLELVDHHVKKLRESNVEHKDIAVLVRSKRIRDNCIKHLKKEKYNLRCVTVENRLREKENAIALDTIKEFKGLESKVVILCDPQYKPNNADTTREFLYTAVSRCFCYLIIISTNDGCKRIETASIHDDESVLRENREYSSEDFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ55</accession>
    <name>A0A6P8HQ55_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b-c1 complex subunit 2, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557711.1">
        <property type="nucleotide sequence ID" value="XM_031701851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ55"/>
    <dbReference type="GeneID" id="116294285"/>
    <dbReference type="KEGG" id="aten:116294285"/>
    <dbReference type="InParanoid" id="A0A6P8HQ55"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF226">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="62"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557711.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21255" checksum="22DFD037034AB396" modified="2020-12-02" version="1">MLPFGRAGPSMVRVLGRTAPSTQKLYASTAVPLSEPILDVQPKENVLKPQNVQVTTLDNGMKVASLETHAPTSKVGLFFEAGSRYEMQDNLGVSHFLRNAAFVSTQDRSSFKIARQLEQCGASLEASNTRDHLIFAADCKRDSIQDVLDSLASITTKPLYNPWELDEVAQRVNLDLAMAAVQPQISKLILDVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ77</accession>
    <name>A0A6P8HQ77_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116291767</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116291767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554835.1">
        <property type="nucleotide sequence ID" value="XM_031698975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291767"/>
    <dbReference type="KEGG" id="aten:116291767"/>
    <dbReference type="InParanoid" id="A0A6P8HQ77"/>
    <dbReference type="OrthoDB" id="5956414at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554835.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19849" checksum="5322653075DD71E3" modified="2020-12-02" version="1">MDQYNQRQKEIEELESELKKRLTGELPASDWCKCGNCAITNLQNISECYCCTEIEGCVESLTTDLVRQELSPEVELSCVTQHPGFQPVCLNKWSLRMAADRFKTKNKQXYRQTGSEERXLRSIAYREFSRLIHGWLGSRRIPLPACAYLAIRDAFPLGTSEVTYTGFDLDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQU1</accession>
    <name>A0A6P8HQU1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMME syndrome candidate gene 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557473.1">
        <property type="nucleotide sequence ID" value="XM_031701613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQU1"/>
    <dbReference type="FunCoup" id="A0A6P8HQU1">
        <property type="interactions" value="2988"/>
    </dbReference>
    <dbReference type="GeneID" id="116294082"/>
    <dbReference type="KEGG" id="aten:116294082"/>
    <dbReference type="InParanoid" id="A0A6P8HQU1"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.700.20:FF:000001">
        <property type="entry name" value="AMME syndrome candidate gene 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557473.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26873" checksum="C31FC790D8920051" modified="2020-12-02" version="1">MPFYCCQTLLVADKERENMNYYKNSNRQVTHQNVYRRRIISKEMAFYCFDLLASHLYRLKEPARPLFTNEPFPVFVTWKIGHDRRLRGCIGTFSMMPLHSGLKEYTLSSALRDGRFAPVTKDELPNLHCSVSVLTNFEEGVNFLDWEIGVHGLRIEFLNEKGHKRTATYLPEVAKEQGWTHTQTIDSLLRKGGYKGHISPEVHSSIKVTRYQSEKVTVSYSEFMAAKQRGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQU2</accession>
    <name>A0A6P8HQU2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel subfamily K member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116294465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557921.1">
        <property type="nucleotide sequence ID" value="XM_031702061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294465"/>
    <dbReference type="KEGG" id="aten:116294465"/>
    <dbReference type="InParanoid" id="A0A6P8HQU2"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031557921.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20502" checksum="AD9372DB5E8AF353" modified="2020-12-02" version="1">MSGYGYITPITDGGRIFCIFYALFGIPLAALLLQSTGKAIFQILVAAIIGLGKKVKQGKVNVKNAEEKSFIGSFLLLTVVIILYSVIFVHGYQQGTFVEGVYSWFITLTTIGYGDIVPGQSSKSLTLIWMWIIFMFLGLSITSSVLNSLGTCIEKRRKKKTFCKCSKWRMGSAVSXDLVPLFSLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS79</accession>
    <name>A0A6P8HS79_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 180-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558023.1">
        <property type="nucleotide sequence ID" value="XM_031702163.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HS79">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="GeneID" id="116294539"/>
    <dbReference type="KEGG" id="aten:116294539"/>
    <dbReference type="InParanoid" id="A0A6P8HS79"/>
    <dbReference type="OrthoDB" id="431588at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028089">
        <property type="entry name" value="DUF4455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027914">
        <property type="entry name" value="DUF4456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14643">
        <property type="entry name" value="DUF4455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14644">
        <property type="entry name" value="DUF4456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4455" evidence="2">
        <location>
            <begin position="131"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4456" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558023.1"/>
        </source>
    </evidence>
    <sequence length="1468" mass="170047" checksum="8C6A198FC37837FF" modified="2020-12-02" version="1">MAQSEVPTPKVVPEGQVYRQIFDAEVSLVESLEKERRSYKSKSAPVLPLVRESRSVTGHGILSRRQREWTQARLNDSYIENPVYYKYAALEAIERDSVPDNYEAIQEVRGLMSDLPKKSQAKSNIVEKIKASRKERHETTLEDMYQELAMISTDLEPRIIEASETLQVKLAENDKEIDHLMQLIEKDDDLIGYEIKDLHKLWINVAAHSSVRQSWIKDMQKSLEQVELDRSSLLRETLRSYDKTLERIAHLMPPDVHRMLEKEALHINSTILTNKRSCADLIAHLLSADIERERKCYIKWQTRVEDWRLLKCKESTRKFSEFMQSPPIKDPPDVQRELECFTLEQKAINSRRHDILESLRNLKPPNSTKSAVYQWHSSLVSLGHDLEELHIKYKTILNEEYEKVIQRCLEEVCKYKEEFIASGILDDVRIDEVLNEHFLPLVGEKQTKFEYEVEKMERSLENLTSFQEMLIKSLFKFVQGSAHLWDLHELGLAHQERTLQESLEKNRQDHDAVNQVKEANLDIVMDKMRQDSTQTALTVSLNQAMALLKTIKQMYHDFHNAQVETACSYPAMVQEELKTYDSEICKYFQVNRNPPKELGKGKAAISPHPQRQTKVGHQALEDILTTSNGTSFYILKEPGEHGLPDTPESIRSMKTCMTFLTENSDAEDTASPYLDAISIKEELFVELRKHVRMEFLEHLEKWKEQALEHSNSVVSAKMEELNSELDLRLHLHEPRAARAQQDVHNVRAAELILHRDRVDQHCKGVVTTLNEFKTRFHEMVEEHDKETEYFKRSVQELEATFVSATKTHELLAIQDQVTNRVEQYMDIIRSSIRSFRHDLDGILSTLRNSNARFRKTFKVFSDGGNFSTDEIDEYRKRLEKMASRIDSSEGSFMGELEGMETKRLEAATDYAGKLEDRFKHHLFDLTYIEKITRWLTNIQVKVKSEVAFSNSQAKKLAVFMATFDRHIDAVEKPNLDKEQVTAREVQASLIPILQAFHERCVYLNALLNDATPSLNVLRSGIKVGFSDEKNADQKDKQSAVKPELKSRKSKKKQKSVQEIDVIEEENKPKTSPLSMTSSKSLDDEDRPKTVPSDLKRTDIEKVKSAGRTRKTSGNKKDQGPKYDKKYLIFGEVPDDGEHFLAKINNILREGLEGLLATAEMYYRQKGLQRLPTRPKAIQENFDACAEILVQRLLSYKTQAEDYHNSCIQELRSQLQKFSTLIVRVPPLAINVVLEEQMKELENKREQKRKEYQQHRTELDQRKQQYQSQLRPSLGHPHNRNEMDSLCQQEIQRTTEANNAIRDHADTLMKMEVQFGASFVEKLAHICETMLLQFDAVLTIDDVLVGVVEPKPKTTKQLLRDKIAGGEENKDKLEPFPSGSATWDGLPTNEFDIEQRMEKITRTPTIKTVKTTQAHFAAIKARDKAYEEYKSKFFAALVSIKEKRNAELDDEAHWSKSWQRSTETIKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSM1</accession>
    <name>A0A6P8HSM1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116294889</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031558436.1">
        <property type="nucleotide sequence ID" value="XM_031702576.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HSM1">
        <property type="interactions" value="2368"/>
    </dbReference>
    <dbReference type="GeneID" id="116294889"/>
    <dbReference type="KEGG" id="aten:116294889"/>
    <dbReference type="InParanoid" id="A0A6P8HSM1"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="115"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031558436.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30090" checksum="D52F3344B2D17EE0" modified="2020-12-02" version="1">MSDHTNNIDEXSSRNHVHDHDVVNENKTESTDSFKTSSHITLDESNVPLLVKKVADLNGMSLQTNRDKCIAPNSENEPVEQEPSSTENAEGVKQTENVLAESVDSLQTSSSDEDIKYVGYESELQMGAIMALITKDLSEPYSIYTYRYFIHNWPNLCFLAMHKGHCVGAIVCKLDVHKNMVHRGYIAMLAVEKEFRRHKIGTKLVKKAIKAMIADNCDEVVLETEITNKAALRLYEKLGFVRDKRLFRYYLNGVDALRLKLWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT25</accession>
    <name>A0A6P8HT25_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase F(1) complex subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP synthase F1 subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116294842</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Component of a complex composed at least by ATPIF1, ATP5F1A, ATP5F1B, ATP5F1C AND ATP5F1E.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558373.1">
        <property type="nucleotide sequence ID" value="XM_031702513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT25"/>
    <dbReference type="FunCoup" id="A0A6P8HT25">
        <property type="interactions" value="1511"/>
    </dbReference>
    <dbReference type="GeneID" id="116294842"/>
    <dbReference type="KEGG" id="aten:116294842"/>
    <dbReference type="InParanoid" id="A0A6P8HT25"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.440:FF:000002">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="19">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031558373.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="17759" checksum="CD114ECF70FF5E7F" modified="2020-12-02" version="1">MLSFSRQILRFSRRPLGAGLRRCLATEAAESGPAMSLTFGSPYESFYENVSVKQVDVSTSTGSFGILADHVPTIQTLSPGVLTVYQGGSSDKYFVSSGIVTVNKDSSVQILAEEAHPLDRFDEQAVNKQLEKAQQELSSATSEEDKASANVAIECAEALLKALHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT62</accession>
    <name>A0A6P8HT62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tachykinin-like peptides receptor 99D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116294870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558413.1">
        <property type="nucleotide sequence ID" value="XM_031702553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT62"/>
    <dbReference type="GeneID" id="116294870"/>
    <dbReference type="KEGG" id="aten:116294870"/>
    <dbReference type="InParanoid" id="A0A6P8HT62"/>
    <dbReference type="OrthoDB" id="6021389at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558413.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38607" checksum="AB0CCF1FB093EAE5" modified="2020-12-02" version="1">MNTTSLSNGSSKPMFTQDQCQNGPIPDGDEQQAMFQAFCRCNILPHPLLVEEIFSKFFLTVSVMGNLLVIIVLYRMKRGFFNAPMKALLQNLSIADTAVCVLYNVNDAVGVGSPLTTSGFCKLFGGLLWASLSSSSCAVCCVSIERYLAVVKPLEFNLTKKKALLMIIFSWYYSLLFTILDFYFLEKIVYKVCLRGDVAICGYSHLPDIDVTVLNLLNIIATFIIPLIIVLYTNVSIMAVMVKSAKAKKKNTTDQSNKHSGVIMIVFLLTAIYVICSVPFTVNYVLNAIPVVIDVPRQFTAVAYYLMLANSSCNPFIYSFFSAEFRRECANLISLPYNWIKDKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTA1</accession>
    <name>A0A6P8HTA1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spindle pole body component 110-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558458.1">
        <property type="nucleotide sequence ID" value="XM_031702598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTA1"/>
    <dbReference type="GeneID" id="116294909"/>
    <dbReference type="KEGG" id="aten:116294909"/>
    <dbReference type="InParanoid" id="A0A6P8HTA1"/>
    <dbReference type="OrthoDB" id="5962744at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558458.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="60773" checksum="997F5D85C5B9307B" modified="2020-12-02" version="1">MDKSRTEMKEVSIVDDDVLEVLELVDDNDTIEECMMMVNKMSETSLLEIQKEKESLKRLLKEADKEVSKLKHSLRTSNCCIEELKTDLTKEKAKADGLEEQVKNCNARIQEMEDYTVQSREEYLEMEKKYFENSKLVEDTNRLLNDVLSKKRHFEEQMDSLRKQRDSAQNGVVSLEKRLREEQDRSRAKAVYCEEKLSKTENELKHTKNKLLTAENDFKLHILQLQGSLKLKKGSSSLIAVDAGKCVAVISEKLDALEKKTLSAEKEKFSLGAKLKELEAVMKDLKEKAEKEQQDSERRIKESENALEEVKKNFNTESLKNALLLKEKNELKEQVKEAEKEKLELQNQMKELKDNYNTAKDSLANAEETIEHLQEQVAQKEKNSCPNENSETSQENRMNQENDFESQEGVEPPQNFEAKYNELKMQYDNLSKQFTQIRKHRNEVLRQNNELRHQAQMAVVQLASTNRRFTKHMEQLKMQLNVAERVYQEKLFECNLLEIQVQHLMQQANGNYPPGTQPPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU39</accession>
    <name>A0A6P8HU39_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116295279</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558921.1">
        <property type="nucleotide sequence ID" value="XM_031703061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU39"/>
    <dbReference type="GeneID" id="116295279"/>
    <dbReference type="KEGG" id="aten:116295279"/>
    <dbReference type="InParanoid" id="A0A6P8HU39"/>
    <dbReference type="OrthoDB" id="5964337at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026624">
        <property type="entry name" value="CECR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558921.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35402" checksum="C157457C49BBF491" modified="2020-12-02" version="1">MQKIAKFFVYIGRFMLVASLVAQAVIFSMYPSIYYKKESFVSLIVLVLPTLIAYGVISYNSDDKPTLNRLWIVWGFYVSTFLIPMVGLIFGGLRENLDKNQFFGPNILKITMCGSALIALLLVSTSLTTKSDDQNKEKYKDLMIRLCWDIAMDLFDDIEMLEMILPQKESLSIPLALDAIIIMCVFLSFIFSIFETYEQALTVEDPSKSYIHVCRLGIQMLLVNVVLLVIRLLLWLRYKHDASIFIAKNAMKIWISILEILKHFGFYDDEAIKGRKREGNQNNAQMPNDQPRRDNLGMGVPYQDDINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU78</accession>
    <name>A0A6P8HU78_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynein heavy chain 2, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116295317</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558961.1">
        <property type="nucleotide sequence ID" value="XM_031703101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295317"/>
    <dbReference type="KEGG" id="aten:116295317"/>
    <dbReference type="InParanoid" id="A0A6P8HU78"/>
    <dbReference type="OrthoDB" id="6017186at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000008">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000007">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000008">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004557">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006175">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="13">
        <location>
            <begin position="210"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="14">
        <location>
            <begin position="355"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="15">
        <location>
            <begin position="502"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031558961.1"/>
        </source>
    </evidence>
    <sequence length="803" mass="91632" checksum="57503EB96D3A1C26" modified="2020-12-02" version="1">MGRIDPMYQFSLDAYIDLFNNSIEKSQRSPNLEIRIQNLNEYHTYSVYKYTCRGLFERHKLLFSFQMCSKILEAAGKLNMDEYGFFLRGGVVLDREGQMDNPCTQWLSETSWDNITELDKLPNFHGIVTSFEQYPRDWHQWYTSAEPENTPLPGEWENACNELQRMLVVRSLRADRVSFTATSFIVNNLGSKFVEPPVLDMSSVVEDSSTKTPLIFVLSPGVDPTSALLQLAENCGMSSRFHALSLGQGQAPIATRMIKEGVKDGNWVFLANCHLSLSWMPQLDKLVEQLQVEDPHPDFRLWLSSSPNPDFPISILQVGIKMTTEPPKGLKANMKRLYQLITEQQFARCHKQDKYKKMLFALCFFHSVLLERRKFLMLGWNIVYGFNDSDFEVSENLLSIYLDEYEETPWDALKYLIAGVNYGGHVTDDWDRRLLHSYINESFCDTALQTPYYRLSSLSTYYIPKDGPLSSYREYISMLPNVDHPETFGQHPNADIASQIIETRTLSDTLLSLQPQVVAGAQGESKEEKVXELAADVLKKVPEEIDYEQTAKILADDPSPLNVVLLQEIERFNMLLRVIKRSLIDLERGIKGLVVMSSDLEETFNCIYDARVPPLWGKAYPSNKPLAAWTRDLVQRVEQFDKWATTAHQPIIFWLSAFTFPTGFLTAVLQTCARQNNISVDTLSWEFVVATVDDSNITQQPKDGVWVKGLYLEGAGWDKKNACLTEASPMMLVTPMPTIHFKPVENKKKTGKGMYTCPCYYYPNRSGTSDRASFVVAIDIKAGAMTADHWIKRGTALLMSLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUH1</accession>
    <name>A0A6P8HUH1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit Tim17-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558903.1">
        <property type="nucleotide sequence ID" value="XM_031703043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUH1"/>
    <dbReference type="FunCoup" id="A0A6P8HUH1">
        <property type="interactions" value="1978"/>
    </dbReference>
    <dbReference type="GeneID" id="116295270"/>
    <dbReference type="KEGG" id="aten:116295270"/>
    <dbReference type="InParanoid" id="A0A6P8HUH1"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558903.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="18588" checksum="7D13590E532EDED1" modified="2020-12-02" version="1">MEEYAREPCPYRIVDDCGGAFAMGAIGGGIFSLVKGWRNSPVGHRFYGSLAAVKTRSPVLGGNFAVWGGLFSTFDCCLMGLRGKEDPWNSIGSGAITGAVLAARGGPSAALRSAAIGAVLLALIEGVGICITRMTADQFKQVMPQPPDPMQLPPKPINPSPQPLSTPEFEQQPQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUN4</accession>
    <name>A0A6P8HUN4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kinesin-like protein KIF13B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559003.1">
        <property type="nucleotide sequence ID" value="XM_031703143.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUN4">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="GeneID" id="116295353"/>
    <dbReference type="KEGG" id="aten:116295353"/>
    <dbReference type="InParanoid" id="A0A6P8HUN4"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22706">
        <property type="entry name" value="FHA_KIF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000139">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="12">
        <location>
            <begin position="1697"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="820"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1473"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1615"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1745"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1473"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1626"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1745"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1757"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1793"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1832"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559003.1"/>
        </source>
    </evidence>
    <sequence length="1846" mass="206961" checksum="3EE991A183B3F754" modified="2020-12-02" version="1">MGSKVKVAVRVRPLNRREIDLGDKVVVDMVDGNQTVLHSPDKKQSKNFAFDHCFWSIDSANEEKYAAQDKVFDCLGKDVLVNAFEGYNACIFAYGQTGSGKTYTMMGVQNDKGIIPRLCDNLFTGISENTTQDITYKVEVSYIEIYNERVRDLLCPRGGNTALRVREHKVLGPYVEGLTKLVVSSYEDIEAIMVEGNKSRTVAATRMNTESSRSHAVFNIVLARTEYDHDTECVGEKVSKLSLVDLAGSERASKTGAEGERLKEGSNINKSLTTLGQVISSLADQSSVKHHKKGVHFVPYRDSVLTWLLKDNLGGNSKTVMIATVSPSSDNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELREEVERLKQLLQLKIAGKLSPEDAGEFEIQEQLSESEKLMKEATMSWEQKEKQTEQIMQERHKALEEMGISVQSSGIAVEKNKFYLVNLNADPSMNELLVYYLKDHTKIGRLNPNLPPPDIQLGGLGILPEHSTMDIEGNEVYLTPMPNARTFVNGKELKDRTLLKHGDRILWGNNHFFRINCPRLPGSEVQPEQPVDFLSAQHELMMNQIHQGPLHESIKALEEQYQADKQGALEKQRLMYEEKIEELRSQVQTNPLGNKFTDRTWSVGSFSSGYGSRMSWYEDRDTPMNYIDKPEQRPLVLKEEVLKANTLVREANQLSEEMNKDTEFAVTLQIPTSSLSFGRSRSGFSSEVAIVVKHKSRGTQIWSLDKLENKIFDMRELYNQCVDEGIAFNSKEDNTDLFFEVECHTLIGVCNVFLECLLHDVSHEYAAPIISQQGEVCGRLKVEVTRVTDKGSDSESIESEDGRESPEDEPEIDDDDEIEEFQLGNRMEVCVRVIEAFDLPPALCNYVFCQYQLWKDKDTVVVPPINASISHPGPKTNTMIFENKQSFDIEITEDFLEYASEGSLAIEVWGNRSQGFDSTHKMNWNYNVEAPQKGLHDRWHELVRKLELWFEVHEINDQGIYAPVELNIREGRETGGVFQLRQGHSRRLVVKVNPVPKSGALPVVCNTISSVSIGSICVRKKHLLGLDSYQEKDLSLLREKWSNSLMKRREYLDQQIHSSMGNQDKSVVDKERESWLIDQWVCLTEERNAVLCPLPGSGIPGSPQPDEDLIRQGLEAHIPVIFLDLNDEFRNGAADDASPAGVDTTLSFENPDNMIELPIIKYDQKQVSATASWDSSIHDAIELTRVTGSNEMVYLIVKVVVGLSSPVTMELVLRKRICIRIYKKQSWKDSLLRRLTKEYRHTCGVVYELVSHIPRQPGEETEERASLAQMAAQAVGEEEEDETVLRRYSKGISNVESLLALDKLRQEVVVKEKLAAIGKPLRKFASTPNLAAASDFSFGTSPGRFDSPDTNRLFDFRGNVSRGREDLLIDLSSSYSSPLSSGAGGVVLRERTARTPNSRPSSLLLELETLKEDSKEDKSSASPSPRVPLVLFDFNGSKSVASDGTISPTDNLRQRTASSDTITYDDNGPTVYDDLPTPTPFTLPKKLSLPAKAENMSADFLSTKTDDVLDLSSTKNEEFKPDSTSQKGDNLILDLLNNDKGELSLVDLENVSVTNDQEASLLEATAIPPNQVSAEGARNLSPYLNSSELQPMGKKNDSDENFMDDGRDELSTSRDDLSSLGSREDLTSSFDSMNEEWDDESVSHLRSGMAVRLAEGKTGVIRFIGQTRFSPGAWIGVELDKPGGKNDGSVKGIRYFACKPRFGSFVRPDKVTPIEHSARERTTSRKFTGSRDNTSRTASNRGLDKTESTSRTSLVKNAAKRRTESPTRGRTDSPVGESRTAGRVENTPSPVVRRENAAANRKKNDWKRRSNILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWF5</accession>
    <name>A0A6P8HWF5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Programmed cell death protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116295867</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Has a lower Ca(2+) affinity than isoform 1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer and heterodimer; heterodimerizes (via the EF-hand 5) with PEF1. Isoform 1 and isoform 2 self-associate; probably forming homodimers. Interacts with CPNE4 (via VWFA domain). Interacts with PDCD6IP; the interaction is calcium-dependent. Interacts with RBM22. Interacts with PLSCR4. Interacts with ANXA7 and TSG101. Interacts with DAPK1. Interacts with SEC31A; the interaction is calcium-dependent and promotes monoubiquitination of SEC31A. Interacts with ANXA11 (via N-terminus); the interaction is calcium-dependent. Interacts with PLSCR3 (via N-terminus); the interaction is calcium-dependent. Interacts with MCOLN1; the interaction is calcium-dependent. Interacts with KDR; the interaction is calcium-dependent. Interacts with HEBP2; the interaction is calcium-dependent. Interacts with TFG. Isoform 1: Interacts with SHISA5, leading to stabilize it. Isoform 2: Does not interact with SHISA5. Isoform 2: Does not interact with PDCD6IP, TSG101, ANXA7 and ANXA11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559686.1">
        <property type="nucleotide sequence ID" value="XM_031703826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWF5"/>
    <dbReference type="FunCoup" id="A0A6P8HWF5">
        <property type="interactions" value="2512"/>
    </dbReference>
    <dbReference type="GeneID" id="116295867"/>
    <dbReference type="KEGG" id="aten:116295867"/>
    <dbReference type="InParanoid" id="A0A6P8HWF5"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16183">
        <property type="entry name" value="EFh_PEF_ALG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000187">
        <property type="entry name" value="Programmed cell death protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF9">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031559686.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21724" checksum="AEA96038A7FC2329" modified="2020-12-02" version="1">MAYYGQQQAYGQQAPGFDQNFLWNIFQKVDKDRSGAISSNELQQALSNGTWTPFNPETVRLMIGMFDRDNNGTINFQEFSSLWKYITDWQNTFRSYDRDNSGSIDRNELKTALTNFGYRLSDRFYDILIKKFDRSGRGVVNFDDFIQCCVVIQMLTSAFQNYDTNRNGWITIGYEQFLSLVFSIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWU1</accession>
    <name>A0A6P8HWU1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid phosphatase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559853.1">
        <property type="nucleotide sequence ID" value="XM_031703993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWU1"/>
    <dbReference type="FunCoup" id="A0A6P8HWU1">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="GeneID" id="116296032"/>
    <dbReference type="KEGG" id="aten:116296032"/>
    <dbReference type="InParanoid" id="A0A6P8HWU1"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="143"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031559853.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34232" checksum="169BAFED3E0AA34A" modified="2020-12-02" version="1">MANEGKSGDELANDEIATHEKYTSFESKYNRPRASLKWLLLDVVCFAVVGLPILVLFLIGVPYKRGFNCHDDSINKPFKKSTVSSPLATAVGLILPGITFVLIEYFLHRSKNQKVANAKDVGPVIYIGPIKLNSLLLKLLKITIVFLFGAAVNVLLTDVGKYGVGRLRPHFLFVCKPKMGVISNCTEGEYITGDVCTGDESLIRQARLSFPSGHSSFAAYTMVFLVLYLQARLNISSSLLLKPVLQIAALILALLCGISRVSDYKHHWSDVLSGFILGTMVAYMVVWKLLKWFKNISGEKQKMSLKDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXW3</accession>
    <name>A0A6P8HXW3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560213.1">
        <property type="nucleotide sequence ID" value="XM_031704353.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296345"/>
    <dbReference type="KEGG" id="aten:116296345"/>
    <dbReference type="InParanoid" id="A0A6P8HXW3"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560213.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="79212" checksum="585B3B30792CAE4C" modified="2020-12-02" version="1">MDFLXPNQANIEEVNHFNHRLQQVGFNDGSGIAESGLQPAFQERIRKFIATKSDLLFQIRGREELKRGIDYGLDNNHEVLDLYSKVPPLEVFMGIPAHXKRWQLFKVMKEGDIVLGEVVSKRPFGIFVKLTALEFSKSRDFTDTNIEALCRTIDLFDKDVHREHKDPSDAFLIGDCVRGVITSVCLEEERIAISFKSAKLPKQHQLLHLGLLEDVDSSEQRYDYSESTSYAEQLETHVGLHNPRNIETLLDILGVDTKQPCSLLRGFQRSHFPEDEYFDVLRNKQSAKWSMESTAKGVELFKGGDIKTAMKYLEHALQIDAENVEALVARGALLANEGKYSVAINDFRQALSINHHHRNANKYLVQTLIEQGIQQEKNGLLTEASNSFKEALELSPEQATAREXLENVKQLLFIKRQREEKRMNDESEVIKSKFSHVRQLIEDEQTRKKKKRKKEKKKRKKQRTEKKKKTRRRCRTTSTTDDSSSIESENKSPLLNKKRGYDEXEQVPDQKRKIXLKDEYSHVDSEPARKTSGVENXIHSESQASLINQSSSTLKSINTETTRRKRRRHSSRSPSTSDEXTSKTRARQRKRXHSARRGSSHSRSSSSSDSRTARRSRRRSPDHSRSPKLSRRDRRSHSTSRESSHSRSYSSDRRSRDKSRSRRNSHQEKWSRSTXRDANHFYGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYN3</accession>
    <name>A0A6P8HYN3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA replication factor Cdt1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116297407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561489.1">
        <property type="nucleotide sequence ID" value="XM_031705629.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HYN3">
        <property type="interactions" value="1294"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116297407"/>
    <dbReference type="InParanoid" id="A0A6P8HYN3"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071163">
        <property type="term" value="P:DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08767">
        <property type="entry name" value="Cdt1_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08674">
        <property type="entry name" value="Cdt1_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045173">
        <property type="entry name" value="Cdt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28637">
        <property type="entry name" value="DNA REPLICATION FACTOR CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28637:SF1">
        <property type="entry name" value="DNA REPLICATION FACTOR CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDT1 Geminin-binding" evidence="4">
        <location>
            <begin position="380"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031561489.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="82920" checksum="5569912FF9F5A0CD" modified="2020-12-02" version="1">MDQPTLTEYYSTKKRPIEGINPAKRRKVIDTEAVVISEVQSTRESARITRQRAKTNAPKPIRAVRTRKARTKNVAKTTENSKLQAFLSLGIKAVTEEAEKVVCEVTSTEDDHEVERASSKETPSLERASTRRRKLQPKQVVNKLETQGSDADIIENTKVKTASRTRRSKRSQKKEIEVTNEVEKLKESASVEKNVENEITEDTKVKDKSASNKNQTKSKQSVMVPEKSPIKAVSSKSGGLKINPWIAEQANRVLLSRGQAALLLSQQKNADTQQTRPRSKEKKPVAEKSRLAKDKAQEGLEKARELIKKMRTLEADSSKPKESSTDDTSERLHKLAKRQATEMASDESASSSKKPPAHERFHSLAQPTPPPSTASVTLPLPYKYKVLGEMFTSCDTILNLLGQRKEACTFEKLKESVQQMCRKRFEKTHLAQMLSLYPSCYDTQQXRSSSKSASYNLVIQFGPGKNSTENRLTVPPAELLSRKKNFQDKLLTVTKRHHQTFLRGLETPLTIDDEKIIRWHPQFRLDDVPDIEKMPLPEAPVIKTITSAQDVLDKGRGFLAPKVEKALQNAAMKSKEKSRIEITYDSQPKGEESNTKTSNVKVNKALRGVSQDLLNKIRQKEARKLEEKLMRDPVLDKNMAMQERLPELCRILKTYFTTEKKAAIPLEDATVKLSESYKSSLSPGQVEEHLKLLSEIAPEWISVLIVRKCPYIKINRKTDINSVIKRVTQTELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ68</accession>
    <name>A0A6P8HZ68_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557897.1">
        <property type="nucleotide sequence ID" value="XM_031702037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294443"/>
    <dbReference type="KEGG" id="aten:116294443"/>
    <dbReference type="InParanoid" id="A0A6P8HZ68"/>
    <dbReference type="OrthoDB" id="5982312at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557897.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44368" checksum="D6E5B8F2CD04C842" modified="2020-12-02" version="1">FQILYDILYKQSSASDQGTMCSNMNVTNNVNAKTNNVEDNFNYCKDFVHNETNAYIVAATMSHFGMKSIHDEAVPHSVRTASTKDKQLWFYNHVKTILEKYVMKKQSEEYSKIVDHVNTLNQPKQRTVFPCSKCGKTYVYKKARDSHLKLKHGVDIAETIAESPKQVEVKEDYVYNYACVRLSLGMLIFNFNDAVKEGDGARIVRCWKYMLLLYKGHGHTKYALAALQLIANTKSLLSSEKAHSLIWNRTVNNKGGAGNNISMDLRMEHIVHXQKEMLSNLGANLNQTPALRCSRAVKPVEDLLSSIDAELTVRRPSGKHTVTRSQSDFQTIVNELHTRAEVFVDKAEEGRQHAAFXHFKRSILSTLEYDKLNSWFNQHKKKWAKQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I025</accession>
    <name>A0A6P8I025_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centrosomal protein CCDC61</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Coiled-coil domain-containing protein 61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">VFL3 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116297056</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CCDC61 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561058.1">
        <property type="nucleotide sequence ID" value="XM_031705198.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I025">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="GeneID" id="116297056"/>
    <dbReference type="KEGG" id="aten:116297056"/>
    <dbReference type="InParanoid" id="A0A6P8I025"/>
    <dbReference type="OrthoDB" id="568137at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22284">
        <property type="entry name" value="HD_CCDC61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049733">
        <property type="entry name" value="CCDC61_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN CCDC61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="157"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561058.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66402" checksum="4389EE8C678610BF" modified="2020-12-02" version="1">MDNRADDDLIVASRRLVFRGIEYVVTLVVNKEENQFSLEVEDRLTADQWRGQFDAKYIEDLTHKTGNFKQFSIFVNMLESALTKGSHAVMLDLLTYSDLEVLRNKRTQKPGSGTQHIPPAKTNSNLHSKRYLILTYSVEFDRIHYPLPLPYVGKPDPVQLQETIRRLNEENKALRDQLMKNSRNGVNLHLQKEVEKAITERDEIQAQFEIFKREIKHAEKANTAKEIRVLKKVVQNLESDLMKEKSKYQRTLNKKTQEYRGVVDELEEVRASERNLRARCRSLTNXLAVYKRGSRASPASSSISIKRSASRNSQSRDRRSTSRDRRSTSRDPRSTSRDRLSDMQNRRSTSLERRSASRDRITSTRRRIPSPAGTGFLGPRPPRFDPTAYVKEKQRKXTEAEEMRGRRRTRSNGSLTRGRSRSLSTERTSRLVPSADKGLKKGLQRTSSIGSLGSRRSSQSSIDGALSDHSNSSRRKRTTKTKKKQQPSGKENRKTHVLSSPEASDVGSYKDLRITNALYSSTPENGRTHSRTKTKHRHTKSSRLPPREIEDSFNRSAEMMEIDARLNALQHFMKANLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1E4</accession>
    <name>A0A6P8I1E4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC116298151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116298151</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562389.1">
        <property type="nucleotide sequence ID" value="XM_031706529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298151"/>
    <dbReference type="KEGG" id="aten:116298151"/>
    <dbReference type="InParanoid" id="A0A6P8I1E4"/>
    <dbReference type="OrthoDB" id="5973987at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF3">
        <property type="entry name" value="MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="13">
        <location>
            <begin position="468"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="784"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="815"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031562389.1"/>
        </source>
    </evidence>
    <sequence length="846" mass="95627" checksum="C96220F3EEC9CB74" modified="2020-12-02" version="1">MIGNIQGFTKSKQSKNKLIQEQAHLTLTSQLRNSLSDLVQRFLKCDLHFVRCFRPNHQLIPYHFDDELVKXQLTYSSVMETVLMRQQGFPVRVAFGPFINRYRILAYRSTMNVKYVANTCEKILWTISGLEWKIAKTKVFMKNSCRDKLEHKLLKTQQGIVIIQKLFRGRIARRKFKLLQFQKERERAIVKDFLSKVENRMAMVFNHFYNQVTEEDGRSKTNTSKRSLVVDNDEIKERALNILMGNKGKWSKNSSSQLSSPDSREDLPKSSTPDLPNRDDESDSATMPSHNLSMIDALIVSPVKVTQPPHLAQNSDSETDEEPRSPQTTGEFSPDGSPLLSISNIFESDAVSPVLSPTSTSSDGASDEDLYSPEPINSITGIFSSENVDMDQETSSEEETLAELSITDIFNDTSANSTIVTSPECDTLLDRPTLAGRESNLSTVSYESTMSKDADDDMKVAMESPGLWCTITCYERDISRGEFHVDRPVIIVDGSSNAFDVTRIGIGSMPITPGDNKVEKVRLCVGKGIKLTIDEKGNMWVKRCSKNKVFVKGHHLSSEVIEVKGVLPKGKLLKIFDFDSFADNLNYVCDPKRYEPGKSEDLLASTKVCICFVKDADQDIDAPCWIEVEMTEPSRVTKVALDLAKDIRRQEREKRGDRTPPILRAKIGKSRQAIAVETWEKKVRPKKYIDSFKYRRRGWARKKVSVNPFDFGXQNHLEKVKAESSRLRTQSSPGDLENVSPNDDFGVSDDVFEASAQEDSFNTSEGTSMSKMFNRANTEGQILSQNKALEVDKSEDISKSKFNRAKTEGQILSKTRTDEEGKKKWAKEKLKAMQATNRRGRHKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1R1</accession>
    <name>A0A6P8I1R1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Poly(A) RNA polymerase GLD2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116297392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561471.1">
        <property type="nucleotide sequence ID" value="XM_031705611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1R1"/>
    <dbReference type="GeneID" id="116297392"/>
    <dbReference type="KEGG" id="aten:116297392"/>
    <dbReference type="InParanoid" id="A0A6P8I1R1"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="239"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031561471.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37278" checksum="E6D5D01E6CA1FDB2" modified="2020-12-02" version="1">MYSSLRSSEILHIYNSQRQTENEKREKEKWRRHLERSIHQTFPHLRLVLAGSTGCGFAVKGSDCDFTLVKQAFSASENGDSVLRQIKAIVESEERNNLEIEFISTAVVPILILNDTKRGLHGDISYGAKNTLYNTFLMRCYGEMDERVTPLVITIKTWAKNANIMNARYHKLSGFALVLLVLHYLQHGCSPPVLPSLHQRHQSFFNHQDPSRVADWLEQEYTPPFISNYESANDNSVEVLFKGFFRYYSTFNWSKVISVRTGGFIALPYTKKWTKPYIRIEDPSDLTNVTRAVYESYGFQIIKQAIAAANQKFGRGARVPDVVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3B6</accession>
    <name>A0A6P8I3B6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine synthase</fullName>
            <ecNumber evidence="8">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Pseudouridine synthase that catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031563039.1">
        <property type="nucleotide sequence ID" value="XM_031707179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3B6"/>
    <dbReference type="FunCoup" id="A0A6P8I3B6">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="GeneID" id="116298652"/>
    <dbReference type="KEGG" id="aten:116298652"/>
    <dbReference type="InParanoid" id="A0A6P8I3B6"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000010">
        <property type="entry name" value="RNA pseudouridine synthase domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="10">
        <location>
            <begin position="171"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563039.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52521" checksum="48015FFE288BC3DB" modified="2020-12-02" version="1">MAGEEKRSCEQEELENTVNKKQLQDEEDEELKADKGKKRKLSKEDKKNAKEKKVKVTARKKPGFDVELYNETSYFVRNGLRYVTPYHFTFTTHCKGRWVGRQLFEVFKDEFRSEPPEYYEKAIKTGKITVNGETATLDTILKDNEIVCNKVHRHEPPVTAEPLEIIESNEDVVVINKPSSIPVHPCGRYRHNTVVFLLGKEYGLTNLYTVHRIDRLTSGILIFAKTLKKAQELEEQVRERRIRKEYVCRVQGDFPSEPIDCEQPILVVSHKIGVCRVSPNGKTCRTVFTKLHGNGKSSVVQCIPYTGRMHQIRVHLQWLGYPIIDDPIYNSPVWGTNRGKGGVTDDQALKVIQALAESTTIMDTDITENRNKSENLMENMAHSSVEDHSEDEKSVGRMEKSLYVKDGDCSECRIQRRDPTPEELTMCLHAISYKGPDWEYQTKQPPWVAQDCKHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I415</accession>
    <name>A0A6P8I415_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295761 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559535.1">
        <property type="nucleotide sequence ID" value="XM_031703675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I415"/>
    <dbReference type="GeneID" id="116295761"/>
    <dbReference type="KEGG" id="aten:116295761"/>
    <dbReference type="InParanoid" id="A0A6P8I415"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559535.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32228" checksum="29CCFEFAF0563DB7" modified="2020-12-02" version="1">MEINVVENVEDYTEAEEPSQNPPPPPPGLFSSNNSLVYKDQRQNRIVQATNFTVKVLNKFEDEKMQGYIFEIKQHARGRAKTWSCALSMQQLCNTQSVFAALQYASKNSLWYKLPKDAPGSSDLALYMFSLGQEFDSVRDESNIIKKVVTKFPSWQQIASNDEQNQLPVTVYVVSEDTQIDVTNKKVLEGAERIVCLTNNKDEIPTQDIRHHVESVVQDEIPPHIHNVEATIHFIPASKEGAAEDVGSRHGKRCRSGSSKLFDKIHPGILKDKRVRKKTKNKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4E9</accession>
    <name>A0A6P8I4E9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116298106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562336.1">
        <property type="nucleotide sequence ID" value="XM_031706476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298106"/>
    <dbReference type="KEGG" id="aten:116298106"/>
    <dbReference type="InParanoid" id="A0A6P8I4E9"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031562336.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27889" checksum="0E0CB3B686D1BD59" modified="2020-12-02" version="1">MAENLNRYLRYQFALASAQSPENDDELLEDVSVKVAKIEKVKPISAASRGRIIQEGLESGKDLYEDAFQYPVLLSHSLIDPKSNKLKDETGDAFVYQVTNHNEEDNVNICVLFYQFDGAIKTIYPPKEGQTAKLRGGNTIQDIFRVFIPYNSLRKMAQPDPTEPEPDRGVDTIVVYAFSKPATLETLLQXPIDLSLIPRGSDKAEPLSDLSAFSVPLRKRCLEDHDNKDLKWVVEKREFAVVKNTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4T1</accession>
    <name>A0A6P8I4T1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AN1-type zinc finger protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116298537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031562893.1">
        <property type="nucleotide sequence ID" value="XM_031707033.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4T1">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="GeneID" id="116298537"/>
    <dbReference type="KEGG" id="aten:116298537"/>
    <dbReference type="InParanoid" id="A0A6P8I4T1"/>
    <dbReference type="OrthoDB" id="756206at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01802">
        <property type="entry name" value="Ubl_ZFAND4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053061">
        <property type="entry name" value="AN1-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728:SF1">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="480"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031562893.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61236" checksum="84A8BFF886AFD09E" modified="2020-12-02" version="1">MDLYIHTLTGTAFELRVSPFETIMSIKAKIQRLEGIPISQQHLIWRSVELVDDFCLHDYNICDGATLQLVLAMRGGPINTRRVPMEDPSLQEMAEYMEANQDEIWDRLPKDNRQVTLLVFRDGDQLNFFRVVDRGDGTLTPLSDSLSGASMYNLYDEEEEESQKPVSQETLKENKVTMNKMKLLRHKLQSQKITKPEMLPHPPSVEKPKTIAPSARRRLRLSDASHKQQTSQKIISPKKPEKSNMKSYLPHPPPPMEANGAKRGEGGGGSGKETKEKGHLPPVNTKKGKQIDVSDFLPNTQDSKPVTSLNSSLTRSAFKDGRRSISELVKDAKEIKPLGSISKPKVTSKHKTSSPQYGDSVEYHLSGSARLQRSKNNHSSRRTSVSPSXDNLEYISGGSTIRRSRIPEEYLQSGYQGEAMPTSAGLTRLRGLENRVHTPESRQNGFRNGSSSYKHNHERSVAPPHHLPPVKTHPPQLVPSKKKTRCFFCGKKTGLATTFQCRCGNTFCGTHRYAEVHGCTYDYKSEGRKIIEQNNPVVAAPKLPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4W1</accession>
    <name>A0A6P8I4W1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295983</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559805.1">
        <property type="nucleotide sequence ID" value="XM_031703945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295983"/>
    <dbReference type="KEGG" id="aten:116295983"/>
    <dbReference type="InParanoid" id="A0A6P8I4W1"/>
    <dbReference type="OrthoDB" id="5956805at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559805.1"/>
        </source>
    </evidence>
    <sequence length="805" mass="91879" checksum="80AF28B9FF4F883D" modified="2020-12-02" version="1">MFKNNFHRNANMNFSIPETLFFFQLPEDYANSTSKSCSKFPSYIYRNIFVFEDVFFENNTGPSFITYFANGKHFLVNCLFKNNYCFKPKTGAHLFIQEGTSSVEFQNTNFIQTIGKPSFLTSRIAKNDTSSMLFVFAGARGPLLLINSNFVSNDTSARSIPHFTIQTEGYVHIDTSTKLLCPVGSYMDLVDGSHLIHQXSNSGCINITQRKFICKMCGVGKYSLERGSYQKKTLKPITCLEFCPFGADCTWNIQSRPNFWGYSTTANYPPQLNFTRCPEYYCRVPKSKTNASVYNRCSGNRTGLMCGACKEGYTESLFNQKCRPEDKCKDGWFWVVAGLFSVIMAGYLLCKPPIVFYLRNNLLWFKHLKPSMQYITHEQEGTTHGHGGHGYSKIIFYFYQVADLLMLESSFHILQKEVFIITLVSFYNFQVNIANSSFGCPFPGLSAVTKELFRSLQVFAVMVFLVVLYFLHWLLWSFRRRPRPHFAPYLAAIIEVLLLGYERLAHTSFNLLTCTPLNINGQEVWKMFIDGNITCWVHWWQYAMIAYNIVFVIPFVLVLLVGTPKLRSGHIGPFYFLAACFLPLPFLVYWMLKRILKCDRCIFDAKEEARDEEYTKHLLEVIQGPFRPPQDQSKGALNWESILIGRRLVLLCLHSLVTTPMLRILSMTFICLLILLHDVVIMPFKDGKTNAMAAFLLCIHVVLGAINLAKATLITAGVSPEGPPKTQIHALQLLEIALLGILPCSFMLLVAACVMSQAIRLMFKAGLYLFSKICFQEEGGGRWYPEQNRECLGESYQPLLDPTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6J6</accession>
    <name>A0A6P8I6J6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299636</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564184.1">
        <property type="nucleotide sequence ID" value="XM_031708324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6J6"/>
    <dbReference type="GeneID" id="116299636"/>
    <dbReference type="KEGG" id="aten:116299636"/>
    <dbReference type="InParanoid" id="A0A6P8I6J6"/>
    <dbReference type="OrthoDB" id="5973453at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564184.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="66441" checksum="CF0ACFD740A1E05C" modified="2020-12-02" version="1">MASLNMQSSCGDKKTSIGQPRDGKDVTLREVINIINATNTKNAPTSSDKTIIQGLTSSSLKERINTNHAFSNNADAMQMSIKMMRKELKEQVKQNKANPKSSRHRLHSSKGKSITSYCYPVSEASWPETIRVAAPTLSRLSSEAESERLVKQSEELSGKDVKWDAESLFSRRSDTESLTNLANQNKNIYSRHLQSNSTETEEDAICFELESSAKDKAAQEYREARRVSSASSVQSLRSDLGPKQAFPSTTKTPLRNRSESQSSQEANDEVAEKLITRNNSKEKIQDEREFVETLTDPTLKTSLQRIIQKRRNSVCLIKSAITGLRVANDDGTFSVIAEENSDLDLESLMAKSDSKISVLSERTIKSSFNSGQKLDRGPREDECAASDWEIKSLKSFRSEASQTSYYQSSIPKRGLVYTQTVSTRKKGVSSGKKFSFCPDKNVRTNKVETEETRIIKPLSSKTYRPCLTATSRAKKRSNTARSSPETSREKNHCVDKGKQDVIREFMLMYAKVKQNKKEAERTVEDNKPVRMISATPEFVVKSAIGQFLSSVFPPEKPRDSSWERERRREDKQRTKLLKIKICMQQLASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I897</accession>
    <name>A0A6P8I897_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase family 42E member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116297247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561297.1">
        <property type="nucleotide sequence ID" value="XM_031705437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I897"/>
    <dbReference type="FunCoup" id="A0A6P8I897">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="116297247"/>
    <dbReference type="KEGG" id="aten:116297247"/>
    <dbReference type="InParanoid" id="A0A6P8I897"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000138">
        <property type="entry name" value="Short-chain dehydrogenase/reductase family 42E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031561297.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43380" checksum="9F5BCA037F0DA871" modified="2020-12-02" version="1">MADSNIYKGSKAVVTGGTGYFGYKLGCALRDTGAEVVLFDIKELDHLSEGLTCLKGNICNKNDVETALKGAKFVFHSASYGMSGREQLNKDLIEKVNVEGTKNVLEACNTNSVPHLVYTSTYNVVFGHDEIRNGNESLPYLPMDQHTDHYSRTKSIAEQSILKANNTKLRDGNILRTTALRPAGIYGEGEQRHLPRIVSYIKKGLFAFTYGSKNSLVDFVHVDNLVSAHVLAGQALVGNMPKAAGQAYFISDGKPINNFEFFRPLVEGLGYMYPTINLPLSFIYIFAFLTELVHAVVGRYIYNFQPMLTRTEVHKTGVTHFFSINKARTELGYSPVDRDLMGVVKHFREQGHGKKVPKKQSSLKYFIINVLIGFAFAFVLMSWLPKVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9C5</accession>
    <name>A0A6P8I9C5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116300021</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="RefSeq" id="XP_031564638.1">
        <property type="nucleotide sequence ID" value="XM_031708778.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I9C5">
        <property type="interactions" value="1162"/>
    </dbReference>
    <dbReference type="GeneID" id="116300021"/>
    <dbReference type="KEGG" id="aten:116300021"/>
    <dbReference type="InParanoid" id="A0A6P8I9C5"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="15">
        <location>
            <begin position="46"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="16">
        <location>
            <begin position="408"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031564638.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="60755" checksum="399907BD387E1FF6" modified="2020-12-02" version="1">MSAKGARDEYVHYVEERHKHWMGSRASSYLEYLCELDIDKQPVTIRNSGLICTIGPASRSVDTIVQLIESGMNVARLNFSHGTHEYHKETIANVRRAALIEWPHAVGIALDTKGPEIRTGLLKGGGSAEVSLKKGQKLKLSTNKDMFDKGDSETIFVDYPNITKVVPVGGIVFIDDGLISLKVTGKEADFLMTEVQNDSSLGSKKGVNLPNCEVDLPAVSEQDKKDIAFALEEDLDMIFASFIRKPSDIEEIRKLLGDKANIIKIVAKIENHEGVRRFDDIVNVADGIMVARGDLGIEIPAEKVFLAQKMMISRCNRVGKPVICATQMLESMVVNPRPTRAEASDVANAILDGADCVMLSGETAKGRYPVGAVRMMHSICREAEAAIFSKQLFDELRHSMDRPADAQEATAIAAVAASYQANADAIVCLTHTGKTATLVARYRPRCPIVVVTRDPRXARQMHLWRGCFPIVYDKPPLVNVLEEHDERLDFALNMGKSMGFLKTGSIFVFVSGWKSGATHTNTIRILSIADERIHIARSLSETADPSGQVQVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAA9</accession>
    <name>A0A6P8IAA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thyroid adenoma-associated protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116299577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564111.1">
        <property type="nucleotide sequence ID" value="XM_031708251.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299577"/>
    <dbReference type="KEGG" id="aten:116299577"/>
    <dbReference type="InParanoid" id="A0A6P8IAA9"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="5">
        <location>
            <begin position="533"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="6">
        <location>
            <begin position="1235"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564111.1"/>
        </source>
    </evidence>
    <sequence length="1922" mass="215810" checksum="0C25D2BB61130419" modified="2020-12-02" version="1">MDKQFSLDLVLRKLDDFKEKSCKHWLTIYTILGDLLRQSAQKKRMILLDRLHVEVSNLRKFSTKNEGEVPHDQQCLQEFARLMSEMFASNILCPKMNQRIIKIIQSVYAICPDVTKEEITKQIDAILSSESEDNSTQTLQNVIIIVESWSLGRQCIEEKFEKVLEITAEWCDKIIDKLEESRKTNIVNYQDTLLLVIKAVLQMFQHFSSKFRQLSQSEVSQAKQELKTLISLLVCVLFSKILVKECLLLAGTALSLLLNSETDESQVINTIIQLLDHTEDKKSPSAESVITICNLETNLPVAGYSPLTRITILHAFITTSRKEILLHDAINGRPFLVSILFGKVHKICKEEINPVIHYLAYEVIKSLMHRIKQLLEDICQKDSQRLFGCDSIFTSQILEHVWDSLEDPVEGVSIAGRGIFGLFLDVHDGEHYILKDEETFRAQFYESIVDKVLAVPWQVKTRYGLICELLPHVTLEQVFNKRPSLLEEMAYCLKSNQLSSASTEAFKTLLLHKRTGKIDSCGSQVDKPFNLQWKNILLKSLTSENPLLAQHTRQYWLPCVLKNVPDALDQMLRDLHSNGGHQSRVVSAHLAILKAARSLGVMESKQLDEELLTSALEDAEDTIRLDALGVLSCSSKTSESLSEIELGLLRNFLCHNLNIACPSFRQDLFVAMRKILSRIRDSCLSELKRCYPKIFKNHSLGVNELQALSVQSDLVHALEFVEWTMTFMVNSLLPGANYQRQKTALELISIIFDTFAVKGNPDKRKGQAPESTIVLMKFSEAKGLWSFYSPRNIHVLLGCLQSSHSDIRELSLNILRHHFSGPLTGLDKSKGDSQFAVDLMNEASQLICSPKAQESESGAVICQLLFERYVVLLDWEVKDIFSDPSAQSQRDADSKERGNHCVQFLSELLAEAERQLSSAKDNIAVAAEKYPIHGILLTLCRCISSYLDTITCPQISQPTFQSFKTILQRTVQVTIEVIDFLLGVLSRKQDSENVVCGASFAGLGEAVEDAISVNSLTDDTTLSQQHQKEFIMSCCFLSIKFGCQLLSNIVEKVSSSGSEDSRFASLLPSSDLTAIGEIFIKIFTHCRLTGILLSCKVSLTIVSRRLSESSIECVYSLPRQWIRNVIDSISGQGAASSVTRRSAGLPVLVVNILASESPNKRQQSVKYCLDKLLNVAFKPIPEVVDQTTDLPQVHAMNILRLLYQDTALGNDVLCYTEQGLVLAVQGFASPLWSIRNAATQLFGSLVLRVLGHKRGLQDENQFNSISARDFFKRFSSLRSFFLEQLRSFSSDTNTQPMSTPCTAVLKPELFPILTLFSKLRPATSDIEESLLSDFIPFLTPLSSSPVYAVRSLAAQALVPFIPIEGFVRKAVELLTTIPSSPQSVSQNTLHGTLLQVHHLVDAMATNSHVTIETGLVLKELQNRLWLGTDLNPCALTKAEYLNILMELAPMASKKADDDLRSLIEHVTLKTNYNYPVQVGLPYLHRALSASALDLVTSEFWSEGSEDSNYSSVIKTCLHSKERETRIASLGHLHHVLQNKTRLTRHDLDEVLTSLITMETDQQCLLLALDCFNDVCTRSDEIMLKGCEQLWVSLLSFTRGSRGSSVQSKAITALSILVYFVFKNLVDQSQMASMATDWSKAISECSMPGKPEPVRNGAARGLGIAGEEVLHFAEKRQGKEYQNLDKIMETAVRIFKTGIMLLEDEQDDVRIAASHFGAKIRHRHGNVNDISSITCSVAITSIFEYMSRVFWWSPPVWVTMVTILHGRCSVMELLTEYTKSRHILFEQEDCNLYAEPFITAQLSCRHLKLIADQISSSKDEQTREIKKQYQEWLQSEAQRLLSDIKTLKNSGIKDTGSLQSPKMFTLRYRLVMMGDVIAHVISSLGNSSLPINDSLKQEIKTLLSDVGKNSVGSHPILHESTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAI8</accession>
    <name>A0A6P8IAI8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116298038</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031562237.1">
        <property type="nucleotide sequence ID" value="XM_031706377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298038"/>
    <dbReference type="KEGG" id="aten:116298038"/>
    <dbReference type="InParanoid" id="A0A6P8IAI8"/>
    <dbReference type="OrthoDB" id="5980853at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562237.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31564" checksum="F952582ABBE067B0" modified="2020-12-02" version="1">MDFELVVSKFDYLQRIVVNLDIDDFVTETIRRAYSLLIESKNTKKSSAGPGYSAGIQRDGSRGRPSYVISKDVLSYFIDQSFKLEEISTILGVSVRTVNRRMSSYGLSVSGTYSTIDDNQLDELTMQASNAHPGIGIRMLKGYLQSKGIRVQRERVRLSLLRIDPIGIVQRWQSTVKRRRYNVKYPLSLWHIDGNHKLIRWRIVVHGGIDGYSRIPVYLKASXNNRADTVLNAFLEATSEYGLPSRVRSDKGGENVDVASYMLSHIQRGPGRGSMITGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBD3</accession>
    <name>A0A6P8IBD3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Adenosine receptor A2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17 18" type="primary">LOC116298418</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562749.1">
        <property type="nucleotide sequence ID" value="XM_031706889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562750.1">
        <property type="nucleotide sequence ID" value="XM_031706890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562751.1">
        <property type="nucleotide sequence ID" value="XM_031706891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562752.1">
        <property type="nucleotide sequence ID" value="XM_031706892.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562753.1">
        <property type="nucleotide sequence ID" value="XM_031706893.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562754.1">
        <property type="nucleotide sequence ID" value="XM_031706894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBD3"/>
    <dbReference type="GeneID" id="116298418"/>
    <dbReference type="KEGG" id="aten:116298418"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="38"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031562749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031562750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031562751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031562752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031562753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031562754.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34747" checksum="53C290E5BC0925E5" modified="2020-12-02" version="1">MNSSSNSSSSLQNQSAPSHNNAGWCTAFAVEAIIITIGNIISILALIYMKSPRKLRRWFLVSLSIADLFVGALALPMYVYFLSASSQTMNKTLLLFQFAYNAVDIFSGLASVFTLTVISLERLYAVLLPLIHRSTRRRYYMIVIGILWFLAALISGLFWMTNVVQMLPPGLFIYTMTICSFASVGIIIVVYVAVWIKIKFFLHKRSRLLGPGEERNIFIALGIVTVVFVVTWLPFNIMNLIANFHVSLLKNLSFNVIFFVKLLHYSNSAINPIVYSLKIPEFRRSCISLFTKTEHDYLLKTRETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBK5</accession>
    <name>A0A6P8IBK5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein Di-Ras2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562887.1">
        <property type="nucleotide sequence ID" value="XM_031707027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBK5"/>
    <dbReference type="GeneID" id="116298530"/>
    <dbReference type="KEGG" id="aten:116298530"/>
    <dbReference type="InParanoid" id="A0A6P8IBK5"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562887.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24248" checksum="8D74AECD9A8FEDA6" modified="2020-12-02" version="1">MKENNKNIYEIVVFGAAGVGKTSIIRRFYLGEFTNVYNPTVEDCYSRVLNLNGKVIVLNTTDTSGSYQFPAMRQVAINRASGFIMVYSLDNRYSFVELKRLFDEIVESKPNAEVPIILVGNKRDMKNKRQISSEQVVKDITEYIRSKGTRNFKLRQIETSAKDNYNIEAVFKEMIEILTNIPCDKSCTTKPKKVLNWLRKFSCTFGSYTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC52</accession>
    <name>A0A6P8IC52_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="5">Alpha-TAT</shortName>
            <shortName evidence="5">TAT</shortName>
            <ecNumber evidence="4 5">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116298261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="4 5"/>
    <dbReference type="RefSeq" id="XP_031562510.1">
        <property type="nucleotide sequence ID" value="XM_031706650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC52"/>
    <dbReference type="FunCoup" id="A0A6P8IC52">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="GeneID" id="116298261"/>
    <dbReference type="KEGG" id="aten:116298261"/>
    <dbReference type="InParanoid" id="A0A6P8IC52"/>
    <dbReference type="OrthoDB" id="447510at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000060">
        <property type="entry name" value="Alpha-tubulin N-acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031562510.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55028" checksum="99E89C5B2F01EC38" modified="2020-12-02" version="1">MEFPFNVNHVLPETVTLVDENFSPFREKFKHDRVLFNSKQKELKNIVDLMGEASAKAQNLKASITSAIKLATSDHRLYILKDPPANNGLGAVIGIIKIGHKKLFVLDYHGNQHEVNPLCVLDFYIHESKQRTGCGKILFEHMIKMEGIEPGQLAVDRPSHKFLSFLKKHYNLDKPIPQVNNFVVFAEFFRDLQAVGLVSRRHQRFSVNNPKDCPPLYPYKRPVDNDSLLPKRQAVSRQSPTNLPSSSRKEVPVTSRQATNEFNTSQPMDIDNTRRSSGEAMATGTSRNSQGNDEFLKEMDVKLPPLAPRPPGRHSASRSQVGSAGSRWILESSGIPDAFNADRGLAARATSYSRYNTSRESSAPEIRTRRLKGDERGQLDSFERVSSGGRKRNLHLTSAGNPLQVAGTPTKQAEYNKSPVKNSPMDVNANKPSKADGVNPSFITSTGNYSVSQMYNNYYGQKRSFGTGWNIFGVPPGTNYGIGRNNTSRTFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDK5</accession>
    <name>A0A6P8IDK5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299775</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564352.1">
        <property type="nucleotide sequence ID" value="XM_031708492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDK5"/>
    <dbReference type="GeneID" id="116299775"/>
    <dbReference type="KEGG" id="aten:116299775"/>
    <dbReference type="InParanoid" id="A0A6P8IDK5"/>
    <dbReference type="OrthoDB" id="9906266at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001907">
        <property type="term" value="P:symbiont-mediated killing of host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.10">
        <property type="entry name" value="Pesticidal crystal protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005639">
        <property type="entry name" value="Pest_crys_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036716">
        <property type="entry name" value="Pest_crys_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03945">
        <property type="entry name" value="Endotoxin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56849">
        <property type="entry name" value="delta-Endotoxin (insectocide), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pesticidal crystal protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564352.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="50216" checksum="C226D64E402FEB48" modified="2020-12-02" version="1">MGEVEVSDSWNNRLKTLAEGLASMIPTVGKVVKVAIQLFWPDDTEDIWSLIKSQVEHLIEVKILEHELDEREAQLNGLKQSLSMYSDATNKERASLLSAIIVQCNELYSELTESDNTIHLIPLTVAHAYLHLTVLRERYEHGLKLYSDATDQDQWEKDLTTKVSDYHSHFLSVYSQWQEWREDEISVSVKTKKKPMGIPPFFYWTAYGKTKDSFDGESVKYSESWNKNKKTFKDVQKRAKLRMYNEANASMMMDAFIRTFSLGNFLPGHENDAAKADTTVSEVSYGPYSVALTKGDHEKKNMATIIGQELKDNNGVITEIHIWAGNFVERIQFHYEGKGAGHAFGAPKVSSKSEHVITLSDTHVTGMKMGFSNGVMARVQFKFSDGSSSDAYGNRGWRMKYKQEVDVDSDFRLVGATGRKGNGPGAVGLAEMMFNFQHISVDPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEE1</accession>
    <name>A0A6P8IEE1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116299637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564185.1">
        <property type="nucleotide sequence ID" value="XM_031708325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEE1"/>
    <dbReference type="GeneID" id="116299637"/>
    <dbReference type="KEGG" id="aten:116299637"/>
    <dbReference type="InParanoid" id="A0A6P8IEE1"/>
    <dbReference type="OrthoDB" id="5972128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564185.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="47033" checksum="E9A63CDA39AB4F01" modified="2020-12-02" version="1">MEQSLLTLVLNSGVASERREACEFLDLKTRVEQEKFRQLSADLERRRIRKYNSHLEEQRKVEKELVGLQKDRLRFEREKQLRKRKNFSSRGRKQCAKSSLKDEKITLPMNEDALGGSASIAFDPKVEKYSRRRRRRKAKTETFITNSRKAEKDTTDDVINFPYLSEGEVKKFHKSCKSATRSTECRRWGAAWLYAKKEQETAMNRSERWTSLLLNAEKEKMRVLCEKMITSKERKPASRIALECWNKPGQEPNLKKTLFASKLNYLRNPETSKKPREVEYTKNVTEDKEDVVLSESLEENDENKKEKCLKSAAKAQSGSFSATKQQGENGGQGYPYRKVKGERDLSFVSPFSKGITLTKQLARFSAKSSKKENTNETNHDTLLQDVTSEDIKRKNNTGTVCFLPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEG7</accession>
    <name>A0A6P8IEG7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Speckle-type POZ protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565247.1">
        <property type="nucleotide sequence ID" value="XM_031709387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEG7"/>
    <dbReference type="GeneID" id="116300508"/>
    <dbReference type="KEGG" id="aten:116300508"/>
    <dbReference type="InParanoid" id="A0A6P8IEG7"/>
    <dbReference type="OrthoDB" id="5989600at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565247.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35737" checksum="AA87D561E82B13DF" modified="2020-12-02" version="1">MDRKVQVEEFFCDNEESSGEKANLDQENAAIEHEFSSPWDDNDLILVVEDQKLHVHRSILKMTSPVFKAMLSSNFKGKDANEITLPGKKVNEFVDFLRQIYPLLDGEITLKNIKYIYRLADEYQMAKVMKDCRMFLFSVTKTKENTIEMLMLAQDIKAEEARQQCYDVLKKMTLTELESLEGFSELDRQSMQVLVLPRVKRLQECMKRILPEFLGSLDALVYLWCHDENKYKMHGAPSTCPKHRIYSSGSSRNINPNLYKLYERIKCNTCKGMFSQMAMNAKGYISPSKTYLSENIVSILEEIVDLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFI9</accession>
    <name>A0A6P8IFI9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">hypoxia-inducible factor-proline dioxygenase</fullName>
            <ecNumber evidence="9">1.14.11.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116300727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:48400"/>
            <dbReference type="Rhea" id="RHEA-COMP:12093"/>
            <dbReference type="Rhea" id="RHEA-COMP:12094"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031565509.1">
        <property type="nucleotide sequence ID" value="XM_031709649.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFI9">
        <property type="interactions" value="2728"/>
    </dbReference>
    <dbReference type="GeneID" id="116300727"/>
    <dbReference type="KEGG" id="aten:116300727"/>
    <dbReference type="InParanoid" id="A0A6P8IFI9"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160082">
        <property type="term" value="F:hypoxia-inducible factor-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031565509.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="45649" checksum="8700F68D0685473A" modified="2020-12-02" version="1">MASRNYRSQLPLPLRYQRLLRLHRYRXFMPNQLTPEMLKYHLRWINQQSRIPKGMICDHCEQLVPDXAKGRYKCVRCQAKYCSKEHQKAASKFHHRSCNRFPRDPSPRNNNNLSSKEILQDEDQAEVIYGNPTNLNQNLNIAKYVIENLRKYGHCVLDNFHGERIAKSVLNEVKALHSQGSFNYGQLQSTSGHGTSNRRIREDEITWMNGNEAGCENISHHMSITDTLLQLCNFFIKENKIEMRSPAMVACYPGKGTGYKRHIDNPNKDGRLITTLYYINPGWDVQSDGGVLKLYPESKFFPDSDKTEVEIEPVFDRLLLFWSDKRNPHEVCPAYKTRYAITLWYFDTDERKKFFEKLKQKSQVSQAKPTEELTPLKEKEVIREKESSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH34</accession>
    <name>A0A6P8IH34_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Creatine kinase B-type-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116301274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566167.1">
        <property type="nucleotide sequence ID" value="XM_031710307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH34"/>
    <dbReference type="FunCoup" id="A0A6P8IH34">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="GeneID" id="116301274"/>
    <dbReference type="KEGG" id="aten:116301274"/>
    <dbReference type="InParanoid" id="A0A6P8IH34"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00716">
        <property type="entry name" value="creatine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000001">
        <property type="entry name" value="Creatine kinase M-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000002">
        <property type="entry name" value="Creatine kinase S-type, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF57">
        <property type="entry name" value="PHOSPHAGEN KINASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="157"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="160"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="352"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566167.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="46038" checksum="AF5E96C16E0B9813" modified="2020-12-02" version="1">MAFFGISRVRLSAAVGVGVSAAALAVIFARRSEVDARTGIKLAYEKFSSMADYPDLRHHNNVMAKHLTPRVYSKLRDKSTASGFTLDQAIQTGVDNPGHPFISTVGIVAGDEESYDTFADLFDPIIEERHGGFKKSDKHKTDLNPNKIKGGKFDEKYVLSSRVRTGRSIRGFSLPPHCTRAERREVEKVVSDALDGLAGDLTGRYYPLNGMTEQEQQQLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNNNKNFLVWVNEEDHTRLISMQKGGDMRSVFERFCRGLNEVERLIKQKNYEYMWNQHLGYILTCPSNLGTGLRAGVHVKLPNLAKEKRLDIILDKLRLQKRGTGGVDTAAVGGTYDISNSDRLGFSEVELVQKVIDGVSLLIDMEKRLEKGKSIEDLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH46</accession>
    <name>A0A6P8IH46_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116301278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566177.1">
        <property type="nucleotide sequence ID" value="XM_031710317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH46"/>
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        <property type="interactions" value="1984"/>
    </dbReference>
    <dbReference type="GeneID" id="116301278"/>
    <dbReference type="KEGG" id="aten:116301278"/>
    <dbReference type="InParanoid" id="A0A6P8IH46"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031566177.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20872" checksum="EE7B6EED513EA9A9" modified="2020-12-02" version="1">MGLLTILKKMKQKEKEVRILMLGLDNAGKTTILKKFNGEDINTIEPTLGFNIKTLEHRDFKLNVWDVGGQRSLRSYWRNYFETTDGLIWVVDSADKRRIADCRNELQGLLVEERLAGATLLVFANKQDLPGSLSAEDIKQALNLDSIKSHHWQIQGCSAVTGEKLLEGIDWLITDIASRIFTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJK3</accession>
    <name>A0A6P8IJK3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Discs large homolog 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031566964.1">
        <property type="nucleotide sequence ID" value="XM_031711104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJK3"/>
    <dbReference type="GeneID" id="116301935"/>
    <dbReference type="KEGG" id="aten:116301935"/>
    <dbReference type="InParanoid" id="A0A6P8IJK3"/>
    <dbReference type="OrthoDB" id="5975473at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052074">
        <property type="entry name" value="NonRcpt_TyrProt_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900:SF2">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566964.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="20815" checksum="5393AF79710F3AA5" modified="2020-12-02" version="1">MDGRIGVGDRIVAVNNINLTRATRQEAVDQLRNSPVIAQLVVEKCAPEDHINTQLPSSMDSGYTHTGSVQYSDYGMEDQPFEVHLIKGPQGLGMSLTGGEMGGPIYIKRLVPGGSAALSGQLQVNDMLLQVNGKSMERLSYREALSILRNCPPEVRLLVKRSKGASYPPYPGFRGSVSSYASYGSYGSMSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKS4</accession>
    <name>A0A6P8IKS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein toll-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116301997</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567038.1">
        <property type="nucleotide sequence ID" value="XM_031711178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKS4"/>
    <dbReference type="GeneID" id="116301997"/>
    <dbReference type="KEGG" id="aten:116301997"/>
    <dbReference type="InParanoid" id="A0A6P8IKS4"/>
    <dbReference type="OrthoDB" id="5983987at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028324809" evidence="13">
        <location>
            <begin position="27"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="14">
        <location>
            <begin position="810"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031567038.1"/>
        </source>
    </evidence>
    <sequence length="993" mass="113942" checksum="717181A675601928" modified="2020-12-02" version="1">MFKYVDFRCLAIVLTVIRLLSLGAFAEECQKSIKAMPWPSIYENVEFFPFGVVFIDGGSNCELDFGPYLNQTKKDVMSTFYLNIVCAKPTQVKIKNPSNVQRKNVISYIIVRKACEIDLEGLAVFSNATDYRVLAMLEGAFMKTPNSSQEVQQLQSQINKIGTLTIQGGSKGLPEIFVKYNWSLMAEIQFFKLSIQSLPKTLKFSMPRLQGLELSHNELVEPPDFPWDDEELPLPGNLSRKAVFNEQYQGTTEVKPNLYRRFLTLDFNKIQNLSRFEFRGHLQRLSIKGNGLKAIGENCLVHLTGINAIDLSVNKLDALPKGIFRGLKDLFHLRLNNNNITVIHVETFADSKRMKKLYLNNNNIERISKGLLLQHEDLEELHLQNNLIVKVEHGALPNNSNKLKNLNLNGNQLQTIPSDVFLTRSLESANLANNVITFEGIIETLHSIIIERLLNVLRKSVSDMSRELRTDSVYIDLTNNNIKAMDTNELTKEQMVKLGMVLQVFEMNFKNNPILCDCRALNITRIIKGIISKYSHINERRFQSWVCAAPPQLKGKRIVSIAEENFVCVRNLSGCPVEGTCSVRQTDGSIIIDARDKNLKQLPHMLPVGTNLEIFLDNNQITELSMRGYLGNVSVLHLSRNKIQQINDSFIESLTKVRQLSIDRNELKRLPRSIESLTSRKTFVSLALHSNYLECDCRSKWMKGWLMNSSDKINDIENVKCASGMSQGRPIYRVPLKDFICEEKKVETKFNPRGNNDLLVIVSVTLGVLLVIITAVFMMVYFFRGEMKVFIYTHFDWHPFDRIDDSDPSKIYDAFISYSSHDQEWVHNELKQKLEGHEPPYKICFHDRDFEVGASIQDNIINSVNRSKRMIMVLSNRFLESEWCRLEFRAAHHKVLQDKTNYLIVILFEGIDTNALDDETRLYLRTNTYLSVTNKWFWQKLLYSLPKPQGTVKENQSLGVQGSSRQMSIEIKEYDTASSGNEKRKEGMEESKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL88</accession>
    <name>A0A6P8IL88_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116302542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the cullin cul-3. Interacts with ubiquitin via its UBA-like domain. Interacts with ned-8/nedd8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567726.1">
        <property type="nucleotide sequence ID" value="XM_031711866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IL88"/>
    <dbReference type="FunCoup" id="A0A6P8IL88">
        <property type="interactions" value="2230"/>
    </dbReference>
    <dbReference type="GeneID" id="116302542"/>
    <dbReference type="KEGG" id="aten:116302542"/>
    <dbReference type="InParanoid" id="A0A6P8IL88"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000001">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000124">
        <property type="entry name" value="Defective in cullin neddylation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="7">
        <location>
            <begin position="59"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031567726.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30500" checksum="21DDFFA91D613A87" modified="2020-12-02" version="1">MHRLKSSQREKVRQFIAFTETNEKTAITCLNQHEWRLDIASDNYFQNPERYYTESRVAVDKKKIVHLFDRYKEHGEEDKILAEGIGHFLEDLNLDPASLKVLIIAWKFRAATQCEFTRKEFTEGMTELNCDSIEKLKNKLPSLELELKDQLKFKDLYQFTFNFAKNPGQKSLDLDMAIAYWRILLGTRFKFLGLWTEFLVNHHKRAISRDTWNLLLDFSNMIEDDMSNYDEEGAWPVLIDEFVEFAKPRLTPGKQTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMQ6</accession>
    <name>A0A6P8IMQ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactose-3-O-sulfotransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568316.1">
        <property type="nucleotide sequence ID" value="XM_031712456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303018"/>
    <dbReference type="KEGG" id="aten:116303018"/>
    <dbReference type="InParanoid" id="A0A6P8IMQ6"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF85">
        <property type="entry name" value="GALACTOSYLCERAMIDE SULFOTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568316.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="60422" checksum="33032AFCC0A99453" modified="2020-12-02" version="1">MARIISRQSFSRQFIALVCLLFSIVIFIXALSRYRSTLSVNDNFLSSSALNSESKPFGVSSLSSSQVIYLDKNGYRVALNSDDVVDFIEDKNLKDVETESVQSSATIPSTWSSNMADTNMNNYDVKREENEAERDETIDYNFALADVEDNLKRHTVPKRPVCSYNQPTKSITQLKTHRTGSSTLANIIYRYGDLNQLDVALPKESSYEYYWPVRFSPSFVDKQYVNSSKPHMLVNAQFDNNSMRNLMGKETFVITILRDPISHFESSFYVSGLDYLFGLENSSNPLQEFLANAQKYMTDYLKKESRVDIRLNHAVNGQIFDLGLKRIHFSDQEVINNXIEELNEAIDLVLIAEYMDESLXLLKRALCWDIDDMVYFKQHTRSNEYKDLNITSKMKEQITEWNSADVSLYKYFNNSLWKNIEAQDNSFFDEVKELKLRRQNLERECIDSTSIDTETGEMRFKLVKDLPTINKYLCDKMNMGETEYIAYLKEKARIRFQDADRLTSKQFEELENRALGNSTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMT5</accession>
    <name>A0A6P8IMT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116302511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567683.1">
        <property type="nucleotide sequence ID" value="XM_031711823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMT5"/>
    <dbReference type="FunCoup" id="A0A6P8IMT5">
        <property type="interactions" value="974"/>
    </dbReference>
    <dbReference type="GeneID" id="116302511"/>
    <dbReference type="KEGG" id="aten:116302511"/>
    <dbReference type="InParanoid" id="A0A6P8IMT5"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567683.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41216" checksum="66AEFD0B694BCCF8" modified="2020-12-02" version="1">MINQTAVNDSSLDMFRLNIPKAEVFLFGCTLSLLIMLITLGNALVWIVFWRFRNLRNLTNYFVCSLAVADILVPFLRVVYIVISIFKERWIFGLSWCEISSMCGVLLCGSSILHLCAISIERLIAIKWPLSYNTKVTSKRVIIVLSYIWIQSSLLSIIPVLPIDIAQHRFNPDTAECEIDWHEDPKLTLLLIFFYFFVPINIMIIAYATILKEARRNTRRVQTFHLRVNGKSTFSVFKKELKAVKTLAVVIGVFFVMWMPFFVTTTIRAFKPERYVSGWLQRLVMTLAYANSACNFVIYALMNFHYRSAFVKVFAGRTGARWIRSNGILPSQNLKNASRRIEDQSTLKQFNDQAWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN21</accession>
    <name>A0A6P8IN21_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein with SprT-like domain at the N terminus</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302719</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Spartan family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567940.1">
        <property type="nucleotide sequence ID" value="XM_031712080.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IN21">
        <property type="interactions" value="2041"/>
    </dbReference>
    <dbReference type="GeneID" id="116302719"/>
    <dbReference type="KEGG" id="aten:116302719"/>
    <dbReference type="InParanoid" id="A0A6P8IN21"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="17">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="292"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567940.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51366" checksum="F94552C2D56991BE" modified="2020-12-02" version="1">MSEDDDLAFAMFLQGQLDNEDSNLERREKTELPTSLVDDAWEMIDPAPDIRQLFLQFNDEYFDGLLGGVEVRWSPRMTLCAGLCCYEGRGGLCSIRLSEPLLKLRPRKDLVQTLLHEMIHALLFVTQNNKDHDGHGPEFHKHMYRINKQSGANITVYHNFHDEVNSYRLHWWKCNGPCQKWPPFYGVVKRSMNRAPAPRDTWWDDHKRKCGGQFTKIKEPDNYDKKKSSNKIKNSEAGSSKEKEKILGSGTPSLPTFFDKMKKKKVTSGNVSSQEETDLKESSKLRNDKFEXYIAENPTKKQKTEGISPFSGIGHVLGGSTSEKTRKLQGKQGLVGMNSSEHNIEKQKPYSSSQETSVTKGKNNKTKNRKKPTDISDKPELTIIDAFRRSNKSLCSNTIDSSEGSKGKPISLGDEDSPSVVPSPSSSSHEVSCPVCLLVIPITNINTHLDNCLTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN97</accession>
    <name>A0A6P8IN97_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116302988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568287.1">
        <property type="nucleotide sequence ID" value="XM_031712427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IN97"/>
    <dbReference type="GeneID" id="116302988"/>
    <dbReference type="KEGG" id="aten:116302988"/>
    <dbReference type="InParanoid" id="A0A6P8IN97"/>
    <dbReference type="OrthoDB" id="10060792at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="1">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568287.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20359" checksum="5BB2BF3A988D342B" modified="2020-12-02" version="1">MADSKSHQTLVNLLQDGLNGSETMYCDIVNSNLFDDFFKEGNLEESLSDASTEIVRIATFEVGNYKPEEVTWKIEDGSICIRGQKSKSTATGATGSKFCRCVPIPENIIAKTVTARFCVGGGLLVVEGKKQKRPPPLKRKTSKTAFFGDSHFSLSVDLGDGVPVTKSLSYEVQEKQPKEERVQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INP5</accession>
    <name>A0A6P8INP5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vesicular inhibitory amino acid transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116302870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568125.1">
        <property type="nucleotide sequence ID" value="XM_031712265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INP5"/>
    <dbReference type="GeneID" id="116302870"/>
    <dbReference type="KEGG" id="aten:116302870"/>
    <dbReference type="InParanoid" id="A0A6P8INP5"/>
    <dbReference type="OrthoDB" id="6021076at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="81"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568125.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="54063" checksum="F5BC149B218233ED" modified="2020-12-02" version="1">MATAGDPETGHMGDEDIALTKSQKHGRVNEGSRLLSHDVEQSSRSRLLSYSHRGGITESLRRLRASTMTVSLLEKPSEDRRASAFMAGWNVSNLIQGTGILGVPYAVKMGGWAGVVAILVIAWICCFTGKLLVDCLYEESKRTGQRKRVRTNYPEVGEAVCPGWGNRIVSIVQVCEMYGGIIMYIVLLATVFHDMLQTVSNLDIYTWAVICAYVAFPGIFIRRVSVIAWISMFSVFSLMCGLGTLIIYCITEYKQMSFKNIPVFNAKTFPIGFGVIVFSYCAHAVFPGVEGSMKEPKKFGSMMNYSFLLAAVMKCLLGLLSVLRFGADTEQVITVNVNSLAFNYLANAFVITNVFLAFPLCMFVVLETWDTKMLPLFPHLQPESKFHWFWLLVTRLLLVTFALFLAIVVPHFGLLMGFVGSFTGTCLSFVFPCVFHLKLKWKKLHWYDVLLRCFVIIFGLVCGGFGLVFSAKELVKSFNSQGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPD1</accession>
    <name>A0A6P8IPD1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="10">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116303480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031568891.1">
        <property type="nucleotide sequence ID" value="XM_031713031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPD1"/>
    <dbReference type="GeneID" id="116303480"/>
    <dbReference type="KEGG" id="aten:116303480"/>
    <dbReference type="InParanoid" id="A0A6P8IPD1"/>
    <dbReference type="OrthoDB" id="67310at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000521">
        <property type="entry name" value="Tyrosine-protein kinase pr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="284"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="493"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031568891.1"/>
        </source>
    </evidence>
    <sequence length="767" mass="86480" checksum="C5DC667139CA8F2B" modified="2020-12-02" version="1">MNIRDDASWYHGSLSREEALNTLIKHGKREGLFLVRKSHTVPGDYVLSLWNCNQALHFQIQCRGDIYFSIDDGPVFHGLDSLIEYYRENADGLPIRLVQNCAGSPPPASARKHGIQTRLHQACMDRNEVLVRRLLRENPLDVNARNENGRTPLHLAALVGDDEIVFLLLQCNADPRCRDNNGHTVLMCACIANHPSTCKILVQQGRANIQDRCTNTGCVALHEAASRGYTDCCQTLIELGAPLHPRTAEGDTPRDLALRHGYVQIADMIDNYPLPPPKTSACLWLHEHLDRKGSLDLFQKWGMKDGQFIIRLSTRDHGYYVLSLVLSKLVYHYQIKSRSDRWFYIDDGPLFETLPHVIDHYSKYADGLPVLLQFSIPPDGKPPVSLALRPPLQRSSSVENVIDSMPSRQNVTESKSRLGRSSSQGYPQPPQDVLPLPIPPLSNPLPRPPVTSDRRFPPRLPPGSQPQPPPDSTASEDKSPMPTQHTLINREDLELGSELGQGEFGSVLRGVWKDPKGKKTPVALKTLHPEKIAHGEQEFLREARVMYGLNHPCIVSLIGVCLGPPLILVQELVAMGALLDYLIDHQSEITPRDLKLWAAQIAWGMMYLEKKRFVHRDLATRNILMSSKHQLKISDFGLSRAVGSGSDYYKASQGGRWPVKWYAPESINYGTFSHKSDVWSYGVTLWEMYSFGQLPYGEMTGGEVIKLLENEGKRLERPDACPEHVYKLMLRCWDLKPERRPTFEELHNTFSTDPLYADVRVARGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPL9</accession>
    <name>A0A6P8IPL9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116303423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568812.1">
        <property type="nucleotide sequence ID" value="XM_031712952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPL9"/>
    <dbReference type="GeneID" id="116303423"/>
    <dbReference type="KEGG" id="aten:116303423"/>
    <dbReference type="InParanoid" id="A0A6P8IPL9"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="26"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031568812.1"/>
        </source>
    </evidence>
    <sequence length="536" mass="60980" checksum="C873EC2539368E77" modified="2020-12-02" version="1">MDGEEIHDFSWAAPSRLSRTLLAPKLFRVFYGACYITMVPFLPMYFRFLGLTAFQSGILGCLRSLISCWSSFLWCIFSEKLAKRKCFLVVLLLIGIILNISVSFVYKQDADFMEYVCHEENVFKNESSFLHAENKSLIHVRSLAFGMHERDMTEAVTKTKRQHQDLELNRTKALQREKEDSVFIMYGFRMDVLFRNLLLITAFAEFFMSAVKLISDSIFADFLHFSKGSVAKSKAWTSLGEIFGAGLVILVIGHYHCSFGLKNSFYIHFYLFGFLGSAAFLFASILHVYEPKTSMIYRFGRACKFVSCNMHALATISILFALGMAESLMSNYMMWYLQDIKASITVMGLMIVIGTFSELCTLFLSKYLIRFGGYTWVFALALLAYSAHFACFSFITNQWLILPVQLFQGLSMTCVWSACSAYAAEVAPIGMERTLNGIMSVVYWGIGHGMGGIGVALLYNQYGPVVVFRCGAGVCIIYALLFILLQCLLKIPDGRFGKLKEYHQLTYDDGYHQTNYQTDWLLEALEAEEEDTHFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPZ1</accession>
    <name>A0A6P8IPZ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Octopamine receptor beta-1R-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116303530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568947.1">
        <property type="nucleotide sequence ID" value="XM_031713087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPZ1"/>
    <dbReference type="GeneID" id="116303530"/>
    <dbReference type="KEGG" id="aten:116303530"/>
    <dbReference type="InParanoid" id="A0A6P8IPZ1"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568947.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33480" checksum="FA4B4D2756D384B9" modified="2020-12-02" version="1">MYITYDIMCGTASIINLVTISLERCLSVTQPAIHRNLSDTTIMVSIAVAWLYALIVGSLTHIKNSSGTWYPLFVSFSSFFLPLFIILVNYVIIYRIADRRARARRSRSLRREIRIAVTLGVVISAFIIAWLPFFIIMLVSMYCKKCKVPYKIVIPLVKWMHYSGSMVNPIIYTYRNRDFKRAFLKILCEWREDKPMTHKKFCNLGANGHKNACNKCKRTSSMCNCPLESDSKEHHECERRTSCCGIDDNCIQEYKTKIIGKKETQIVWKNGQNNALEDLDLRGCENKTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQW9</accession>
    <name>A0A6P8IQW9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116303290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116303290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568667.1">
        <property type="nucleotide sequence ID" value="XM_031712807.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568668.1">
        <property type="nucleotide sequence ID" value="XM_031712808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQW9"/>
    <dbReference type="GeneID" id="116303290"/>
    <dbReference type="KEGG" id="aten:116303290"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653219" evidence="1">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568668.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23872" checksum="683F5308ED6E1002" modified="2020-12-02" version="1">MMNVVIHFYVVLVFVCGSHALPKKEKLNDSNLNTCLFDCGRCVGILGEDKYKRDACMEKCEETNGASRDPDCKNSDFVKVDKLDACLNACAHCTFIHGKSVYIGGACLKECRKTKGESIDPECKNPEFLMTEKERECLASCKECCLEDYENYNHVICRSKCRYTKGASNDPDCTKFQRKSGKKHGINRKNSFLHRNKNLFKNLDYLSRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISI5</accession>
    <name>A0A6P8ISI5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569295.1">
        <property type="nucleotide sequence ID" value="XM_031713435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISI5"/>
    <dbReference type="FunCoup" id="A0A6P8ISI5">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="GeneID" id="116303828"/>
    <dbReference type="KEGG" id="aten:116303828"/>
    <dbReference type="InParanoid" id="A0A6P8ISI5"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="88"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569295.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22084" checksum="5BA08A95B89FB15A" modified="2020-12-02" version="1">MSSGKTLITTLDVTNYRPEEISLRVENRKIHVDGKHHSEGKYGSETSEFHRVFALPEGIDPSSVSSRITHDGVLHVEAYKTPTQDLDIALLGCSSQDVSRTDDKKFAVTLNVSDFSPDEVEVKVKGNELSVHAVREKQEGGMSSSRQFHRHFLLPKDVDMAKVVSRIDKQGQLHIEAPRLEQIPSNRERQLKITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISP0</accession>
    <name>A0A6P8ISP0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569922.1">
        <property type="nucleotide sequence ID" value="XM_031714062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304336"/>
    <dbReference type="KEGG" id="aten:116304336"/>
    <dbReference type="InParanoid" id="A0A6P8ISP0"/>
    <dbReference type="OrthoDB" id="5977689at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569922.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36251" checksum="0C48DCC067F6FBCD" modified="2020-12-02" version="1">MRHGMRIKKIRRVLKFTQEPWMRSYIDFNTQKRTAAKKDFEKNLFKLMNNSVFGKTMENIHKRVSIKIASTKEEAEAYVSQLGFVRYAKLLNFYVIHMKKANLYLXKPVYTGFTVLDLSKLLMYEFYYDKLKPKYGDRCRLLYTDTDSLILEVQTEDVYQDCLVDIDKYDASGYPKEHFLYSAKNKKVILKMKDEMLGKPIVEYVGLKPKMYSVLKLDGVEKKAKGVKKYVVKKDITHESYINVLRTRKEQRHKMNSLRSYGHQIHNVTQEKVSLSAFDGKRWMCDDGIHTIALGHHTISSSSLTNSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISR0</accession>
    <name>A0A6P8ISR0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304361</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569947.1">
        <property type="nucleotide sequence ID" value="XM_031714087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISR0"/>
    <dbReference type="GeneID" id="116304361"/>
    <dbReference type="KEGG" id="aten:116304361"/>
    <dbReference type="InParanoid" id="A0A6P8ISR0"/>
    <dbReference type="OrthoDB" id="10274997at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027996613" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569947.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12780" checksum="49BA0DD0BFAE70D6" modified="2020-12-02" version="1">MLKYYFAFFWLLLCYKSVAKTEIRSGYYQKLQEDKQNFIILARTKQLDDFACVLACTHAKLAECKGVIYSAQDGSCFVKFDEREIGTILPEDIILYKGEPKGWFHKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT88</accession>
    <name>A0A6P8IT88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304777</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570416.1">
        <property type="nucleotide sequence ID" value="XM_031714556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT88"/>
    <dbReference type="GeneID" id="116304777"/>
    <dbReference type="KEGG" id="aten:116304777"/>
    <dbReference type="InParanoid" id="A0A6P8IT88"/>
    <dbReference type="OrthoDB" id="5959826at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570416.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43183" checksum="2F2487496C93295C" modified="2020-12-02" version="1">MFKTDNKGFPYCQCFPILELPTVVLFHVIEYLNKKEKGILSRVNRQFREIMKSPNHWKNTTFVLSPKKLVQCKHIVSLLSPRKAESVIFSSTCSKEFQRAILVGIPSLRAITTDNPNPSTLELIVSHAKEITKLHLGMVSTQKTPDLTLHFKELENLVDVSLDRHVFKFDVSGGWIGNWGREGFATLKQNSTLKELNLCGSLRSNAIITQTIHWLDTYSSLIYLNLSFSLDERVLRLALLYLYKLPNLKKLDLTKSALQNNMFRENHPKLWSIELKSCFEISGQTLRTLSSVMGNSLQYLGLSNCNRIEDKDLTSLITMFSCLETIDLSGCTGISDMVLFQNFRNGKLRKIILKGCSNVSEEAIQMVRKNTMNKLTVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUA1</accession>
    <name>A0A6P8IUA1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304954</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031570619.1">
        <property type="nucleotide sequence ID" value="XM_031714759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUA1"/>
    <dbReference type="GeneID" id="116304954"/>
    <dbReference type="KEGG" id="aten:116304954"/>
    <dbReference type="InParanoid" id="A0A6P8IUA1"/>
    <dbReference type="OrthoDB" id="2405788at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031570619.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38095" checksum="4D937344003C1C90" modified="2020-12-02" version="1">MDTITSIRNKTVRRLRTQVLDRLDADFAFTTFMEGDTDETMTEERAERIINLIPEGNYRLELTFIKYLDGEWMIEKGRNPIRASGKKDLFVLNENTRPGALVGIDMLFYEVAYPVTVVIYGAYEIKTPDVKKLKPMRHPGNCVGKLVREFFEDSSRGGKLTLKRREAIRKWEKDTNRTGGSIDNIKKLETALERRIHVKDITDGFIYSGTHKYGGRGAPIVIYQHNGHAWRELRFPRKKETKVYKNSPLAELIHENSIWLMDSEGSQFMTQDGTLYRPEIEQQRIQSACETLGEDFSDEVLSSRSLDFLAAKKRNGWKSTPEEFKDIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUK5</accession>
    <name>A0A6P8IUK5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC116304288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC116304288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569855.1">
        <property type="nucleotide sequence ID" value="XM_031713995.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569856.1">
        <property type="nucleotide sequence ID" value="XM_031713996.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569857.1">
        <property type="nucleotide sequence ID" value="XM_031713997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUK5"/>
    <dbReference type="GeneID" id="116304288"/>
    <dbReference type="KEGG" id="aten:116304288"/>
    <dbReference type="OrthoDB" id="5972687at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653239" evidence="1">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569857.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23252" checksum="8ECA878B153D675F" modified="2020-12-02" version="1">MPSSIITGAALFLLAHAFLADAGYNACEYSELTKCNNVFMSSFKLPVLQQTVGGVYCHGFQVYANCLSASLCFGKFLDLSRFMILQHMIMDKTLNVCPLHNLWSLKNTVQANKKYRKKIDQIIAVDADDYADCAAKIHRDCTSQMAKDLASNDKMCFGVENFLQCYENHKNSCKAKIYKHFLNTVKKVAKTLVKMFKERKGVMPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW66</accession>
    <name>A0A6P8IW66_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305751 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571596.1">
        <property type="nucleotide sequence ID" value="XM_031715736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW66"/>
    <dbReference type="GeneID" id="116305751"/>
    <dbReference type="KEGG" id="aten:116305751"/>
    <dbReference type="InParanoid" id="A0A6P8IW66"/>
    <dbReference type="OrthoDB" id="5966728at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571596.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="62697" checksum="DD4C3693017BB228" modified="2020-12-02" version="1">MAEEKYDFLLNNELNSYQIAIAFDLANSLRADEIENFLEIYDSIPESIETELIDQIKEMARQLAALPKIQFDMYRTKSRVLGSGDHFESPLTSSKNTKRKMTFDSAGNHITMNISNNGGCKNEEKINVNNVLETEENKVTSAKSAKKKLKKKKKSKAVFLEENPESSNVDISSKNAKDSSQNPKILMTNKLIDPDQSSSRIATMNRTLVADICAVSCFNSQGMNSNETSNKICKKKDGDSNNPNICPKQESKPKTTDENYSHDINDSDNHQSAPPFGFPLSASRLIESAVDLLDSCSGATTSSYEHTGMQNKDNEIYVQQKNDTIGDVRQSTVEINGCVQINCNESNSKIDQITSKKCEPHGETDSVDGDISNLSALEDEGGWQSQVRRSNRKKKKELAARNPRERSQSDHKSKKNFQKDYKTNSVKKQNSKNNTSNRNQSGKCKEILETYTPNNATKDNGNGLYSKRNEEKDRKQEDAKETFSYRDALLKSKPKSSEELQYNSDSGVDVNSVGSCDSAIHSSKTFCEFDLKEAVNFLNKGCNEVRVRHKQGRVHHYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW85</accession>
    <name>A0A6P8IW85_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="12">ARD'</shortName>
            <shortName evidence="12">Fe-ARD</shortName>
            <ecNumber evidence="12">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="12">ARD</shortName>
            <shortName evidence="12">Ni-ARD</shortName>
            <ecNumber evidence="12">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116304684</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="12">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="12"/>
    <dbReference type="EC" id="1.13.11.53" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031570315.1">
        <property type="nucleotide sequence ID" value="XM_031714455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW85"/>
    <dbReference type="FunCoup" id="A0A6P8IW85">
        <property type="interactions" value="1358"/>
    </dbReference>
    <dbReference type="GeneID" id="116304684"/>
    <dbReference type="KEGG" id="aten:116304684"/>
    <dbReference type="InParanoid" id="A0A6P8IW85"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000031">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0533">Nickel</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031570315.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="21072" checksum="95FDBEDF9B6D49B4" modified="2020-12-02" version="1">MVRAWYMDSSDEDQRLPHQLDPPQPVSLDQLKQLGVLYWKLDADNFDAEGLLDKIKKERGYTYEDNITCTPDKLPNYEQKLKIFFEEHLHSDEEIRFITDGSGYFDVRDFNDKWIRIEVVKGDLIILPAGIYHRFTLDDKDYIQAKRLFVGEPVWTPHNRPADEHPARQEYVKMVKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWU6</accession>
    <name>A0A6P8IWU6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116305725</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571552.1">
        <property type="nucleotide sequence ID" value="XM_031715692.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305725"/>
    <dbReference type="KEGG" id="aten:116305725"/>
    <dbReference type="InParanoid" id="A0A6P8IWU6"/>
    <dbReference type="OrthoDB" id="5962029at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571552.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23221" checksum="28ED3B1725992E5F" modified="2020-12-02" version="1">MELYEQLTPTSVYTAYKTGTTDKNNVTCRMCGEGSECLAHVLAGCPSLAQSKYLDRHNAALKVFFFEMVRDLKLADSTPPWFSDVKPKPLYKSTDAEAYWDVPVYADHMYVRSNRVDARFIDHNNKKLLMVEMSCPWVNNREKKDKEKTKKYGALRLEXTKQHPGYTILQVNLILDALGGWSKEMEPEMKNLWSKIQRCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX92</accession>
    <name>A0A6P8IX92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116306096</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031571991.1">
        <property type="nucleotide sequence ID" value="XM_031716131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306096"/>
    <dbReference type="KEGG" id="aten:116306096"/>
    <dbReference type="InParanoid" id="A0A6P8IX92"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF46">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571991.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39307" checksum="3D81B025821B1DF3" modified="2020-12-02" version="1">MAFFSLKFRVNSTIRCMCSVVPVRVRSISNNPVQTQQRLQSTNAPASNRFALTIAQKAQFENEGYVVVNDVFDKEHIQRMKDVLDECEEKARSMTKSTNHFTLDPHHTPENPMLQRVHIPSLLFPVFEDTIRHERLLDIVEQLIGPNIRYIKQDKVNLKLPKGTGFPIKWHQDWAFNPHTNQKILMAXVSIDDTTKENGCLQVVPKSHRGPLLSHFKDGEFASAINDSRFDPSSAVHLEVPSGGVSLHHVQAIHGSAANLSEKKRRLYVYQYCSTDAWPLLGVSSLEWGNTXPLDWNRFTSTLVRGEVTFYPKMESIPICLPIPFDKGYVFEHADNIKSSHENPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXB4</accession>
    <name>A0A6P8IXB4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC116305937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116305937</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571798.1">
        <property type="nucleotide sequence ID" value="XM_031715938.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571799.1">
        <property type="nucleotide sequence ID" value="XM_031715939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXB4"/>
    <dbReference type="GeneID" id="116305937"/>
    <dbReference type="KEGG" id="aten:116305937"/>
    <dbReference type="OrthoDB" id="10310323at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057507">
        <property type="entry name" value="Sha_B-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23328">
        <property type="entry name" value="Sha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Shavenoid isoform B-like N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031571798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571799.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="62043" checksum="80C423806F4A0EBD" modified="2020-12-02" version="1">MDQRILFLFIVQVVVLILLNYIPHVYGKYCWIMRDKRDKIVVLVNKTSCTQSNNPCSKLSGVLDLSQTECTCVCPSSKPTYMQTTNNCSAYSDVWSKCNLSFRRQLSEIPIFPTTINFRGLRLNIPNKFRKCKMVVKGENSFYLSESGWSQLPHNNYTFPFLVETKIVRKRLKLAHVKWNTEVPPELFGKVIRIVITCGGKQDCVMLKTQGDTLYQCIVDPRPENPSSSSSPSMSSPSISSASMSSASTRPTRKHVIVSEPSVSNKNFKKSSSIKIPWSIIGTVIGVLLVLLLCLIIMAVCFCRRKKSSQKKRTDNASTQSSGVTLSSTESQPEVTYASPHHPYQELKPPISGTPRGTYQPLKWNAKEDASGYMLPSESTTNNHPDPLYNEIGSPIRGLPPVYDYALPENTVRFSNHLSNMDLRLNGLPTPDARNNPDYVGRASQEQEEPKSLSLKGAASAPVNDGPTSPAYIDFTSEEGANQTEPLAYKSSDNIVTIGSSGLSKYKKPVNVPKSPFKKSPSEERPYQELKSPGSPVYEPLRPSSEKLEGAYKKESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXF5</accession>
    <name>A0A6P8IXF5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116305913</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571772.1">
        <property type="nucleotide sequence ID" value="XM_031715912.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IXF5">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="GeneID" id="116305913"/>
    <dbReference type="KEGG" id="aten:116305913"/>
    <dbReference type="InParanoid" id="A0A6P8IXF5"/>
    <dbReference type="OrthoDB" id="5955161at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="36"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031571772.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36042" checksum="B4C9BF1C04062CBB" modified="2020-12-02" version="1">MNNSTAESFFTDAGSKTADILWTTTYFIQAFAVFLANLLTIITFTINRHLRKRSVYCVMNLAVADMLVGLGILIVNISAMATFGLQSILNKTFDNFGKSFAKIQLSIQTFTANATILALTLVAVERMCATLWPLXHRSVDSWAFVISITSTWLLTLMITMSGALINTQVEDAGKVSFYLAGVWSCLILLVLCLSYIVIYIKVKFERRQMAGQRISRQERGLATTLFIVTVASVVTWFPLGFLLLFRVSNSVYVPNEAHLVCVFLVVTNSLVNPVIYVFRIRDFRRALLKLVLRCSRDRPTQIHPVQNEMQDRLQGTLEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZB8</accession>
    <name>A0A6P8IZB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116306868</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031572851.1">
        <property type="nucleotide sequence ID" value="XM_031716991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZB8"/>
    <dbReference type="FunCoup" id="A0A6P8IZB8">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="GeneID" id="116306868"/>
    <dbReference type="KEGG" id="aten:116306868"/>
    <dbReference type="InParanoid" id="A0A6P8IZB8"/>
    <dbReference type="OrthoDB" id="6351677at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029281">
        <property type="entry name" value="FAM194_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093:SF16">
        <property type="entry name" value="FAM194 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23093">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14977">
        <property type="entry name" value="FAM194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM194 C-terminal" evidence="2">
        <location>
            <begin position="547"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572851.1"/>
        </source>
    </evidence>
    <sequence length="1202" mass="133622" checksum="BAB158166456E83D" modified="2020-12-02" version="1">MLSRMDLCFFADIRSKKRKYRRYRKPPELLPFSVRLTGLSGAVRVEAYLKQQRAKESKNKEETPEKVDQDQGEPTEAPGPTGGEQNQTVLNNLYKLGNDLKQESEEKKTEKKNIHLPNISLRHFGNTGIKSFEQLEGDDEEEDTQRFLFEENKFAAPNLLAQLGKLIDFVHGKQVEELEDILSTSSQLSGSPVLIEEPEAEVTETLRSGGVVIQLPDDLSQKLLNNYEGLSANAVYVKREWQTASYREQAILQKRLGTTDVQQFLEGQKPDTTNQVTATTMDAVNKKDNENIKSSESKDALKKPVKKDGESNELIGNKSSMNKEFVHEGAASQILSQRRESRASNVFIKPKTRIEKFKYYADKGESLASTPVRTRKTSTQIHNLGYSGAGYSSGGGGGGGGGGATPGGIGRGGSSVPRGSIVPDHVYFEDQTFDEEFKETSEVPSVQMQAPGQPSVINFSLLSKQCEDRGWIVHQSDADDLERTTMIEWARARLLQVIKERDEAEIRAKELGDDGPVVQKFYGDSQLEAAMKYKKGVSWAKRWKKMTENEKKAKFLIGIPDGTTYCYYPSGRVAVCAIRSGVGLPGKYTFVYGDTDDQPMLASFLPTGVGCCYSDTGSIKFIATHKFGSLMEEDGKVEKKWKWPLGKLQSPVVVSLNQHINLRCISQTGLTLYFSCQNESTKFQVGMANGAKTVRIEELGYLQTENKFTSLAAIQSIKVKPKKKEKRKRAQKQPKVEAITEEILEDRRKELEEKFPERKEIETDAPWQLDLMKLQRKVKNLVYDWMDHYRISVGITAPHRASSRAQQRRLLAHSARSLPGAMPSGMQRTHGIPSGRSPSAPPIPRAKAMTKFGSRRGTPSPSRSSHSAVTGSRTDRPFDGDASKGVTIDIPQDGYSGVYHGKTGSIASGSRSHSMALSRVPFRCGIAQQPRSVTPPKSGCCVALRAEILGDQYPQCRCDRRRIPLITDLEYDIFIREHVAKTQMVVVSVTSSSFPDANPCDSMLDKLFYEGNRNRSIPCVQARHDPYRLLRYDIAIAALDTDHAQPLLLTRHNAVPGMFLMYIGGKLLFADHIFNGYGNARKDFLKQIMKTRKDSLAGNALPYDFRLSPTRGRSGPRAAWGGEIGGPKISTSQLAIHSEDSSRITSASTQDSKSTTSVDIRRGAQSATSFVNLGLSIDSPYPMTPRRLDDHLKELPKLNTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J185</accession>
    <name>A0A6P8J185_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Apelin receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571570.1">
        <property type="nucleotide sequence ID" value="XM_031715710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J185"/>
    <dbReference type="GeneID" id="116305736"/>
    <dbReference type="KEGG" id="aten:116305736"/>
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    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="68"/>
            <end position="89"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="197"/>
            <end position="222"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571570.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42087" checksum="3834FAD162F3E7F3" modified="2020-12-02" version="1">MNMEPNGTEAAFTGKGNGTRSGSLDEGFPLVLVIFYSLLYIGIYIVAIAGNVMALLTCFKNYRITTSILLVYIASLASADLLFILLSTFDYVYFFTKNWPGGNAGCKLQGFLIETSYSASILTLVAISYERLRSVASKTLARKQRIERRTIITKAIWVFSAVISVPLLYGYSVIPEEMTGNSLCVNNVSWGDKGRQLYYSCQAVFIYLVPLFFMIWAHYRIFRVLKVHTQKKMISSVESKQRKITHMLAVVTLIFFVCWSPFIVVRALRYFYAYEGLELWKLTQLVILLNSAVNPVLYCFYSGQFRSAFKDMIRCQWKLNLRKLSTRGSRRHRDGLHSYSPNSFADKSEADHSSSSWNKLETLKINNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2W0</accession>
    <name>A0A6P8J2W0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116306472 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116306472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572398.1">
        <property type="nucleotide sequence ID" value="XM_031716538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2W0"/>
    <dbReference type="GeneID" id="116306472"/>
    <dbReference type="KEGG" id="aten:116306472"/>
    <dbReference type="InParanoid" id="A0A6P8J2W0"/>
    <dbReference type="OrthoDB" id="5968732at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF108">
        <property type="entry name" value="FASCICLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028021640" evidence="9">
        <location>
            <begin position="25"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031572398.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="57684" checksum="25FD48AD8A81345F" modified="2020-12-02" version="1">MAIKSMLLLLVLVVICAELPRSYSFKFTKWPNNPLVVYYYKNKTNVELRWEWNLEGGIFFFLKIERYRKDNPLGTETQIAKYYSSGTTNVEETKYGLSVQNRAIGSVVFTIKEITNQGINEGKENGEKSRVDVMEANKEYIYSIEVDEQTSGKAFTNSVALKMLKTPVITTYPNNQTVTGGDVTFECVADGKPKPTITWDKIGSSQALSQGSPLTLKNFEASNIGVYRCTAKSNGIAETANATGFVQFSTCGPGCDKEELAIEFTDLTYNNEYDNPSFKKYKELKNKIETECLTAYALKGKTIHKCEVVRYRKGSVVAVLELGYPTNTLDPKEPLLQAINDGNFAGYKVITKFVSPTSPPTEKPSPTAPTTPTASSNTPPASGARTNESGLSKGAIIALVVVFSIIFIVIIVVLIVCMLKKKKPSDTRNKPYKEDGRTYDKSSTTVPLKSQPFDPMYDDPNENRKEVVYADLTFQDRYPNGGGPPPQYTPSNYAEVKPNQPDDSQVEWDKSVKDEMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3C5</accession>
    <name>A0A6P8J3C5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ciliary microtubule inner protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CIMIP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574147.1">
        <property type="nucleotide sequence ID" value="XM_031718287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3C5"/>
    <dbReference type="GeneID" id="116307954"/>
    <dbReference type="KEGG" id="aten:116307954"/>
    <dbReference type="InParanoid" id="A0A6P8J3C5"/>
    <dbReference type="OrthoDB" id="8181742at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052329">
        <property type="entry name" value="CIMIP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924:SF1">
        <property type="entry name" value="PROTEIN FAM166C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924">
        <property type="entry name" value="UPF0573 PROTEIN C2ORF70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574147.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18707" checksum="DBA18FD219C3A775" modified="2020-12-02" version="1">MSTFRWMLLRLMYVLPRSRRYAGFRPQYKWRYGDTFGNDTAKYFQQKRSLTLTSYTAKDSGMGWDTKVQLPSVYSNVPDLVLGARARDGNRMLAPIKYTLLNHHDRDEDIRDFLKKVQDHRCQYVDSSGTLPRVDYFVLPTKNDIKSFSTTRCGDDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3N8</accession>
    <name>A0A6P8J3N8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116308361</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116308361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574626.1">
        <property type="nucleotide sequence ID" value="XM_031718766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3N8"/>
    <dbReference type="GeneID" id="116308361"/>
    <dbReference type="KEGG" id="aten:116308361"/>
    <dbReference type="InParanoid" id="A0A6P8J3N8"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="63"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031574626.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38936" checksum="46862A68B8E30258" modified="2020-12-02" version="1">MENNGILRRCPTTIDWEKIERSSPEEQIEFFSEWKDKFEVELVSSGGKNVKKGDHLAIERYKILPNGSPLYTHHAICTSIHRDTKMITLSEYAGNISGILDVHQSGLKSLAKIKNNEYNAADLEEKMAYKVIWPKELRRYGVKKVTKRAKKRKDEQTYDPLKNNCEHFATWCKCGLNISLQARLWCLWARKIVDKILAGGNAIIESIVPVLLRVLATVPNKSVAAFASKSFAESLMSNLVEKGFINDTVISNIKEIFDEWMMKNADELLYERLVRMIKKTVSKFVEESCRTVGSMADSVYQSVKKGFGYDSVDGVDCVDGDDGDDGCTEELFNEFIEWCNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J652</accession>
    <name>A0A6P8J652_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575224.1">
        <property type="nucleotide sequence ID" value="XM_031719364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J652"/>
    <dbReference type="GeneID" id="116308861"/>
    <dbReference type="KEGG" id="aten:116308861"/>
    <dbReference type="InParanoid" id="A0A6P8J652"/>
    <dbReference type="OrthoDB" id="5966909at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575224.1"/>
        </source>
    </evidence>
    <sequence length="1109" mass="124860" checksum="D66F85AB55342EA5" modified="2020-12-02" version="1">MLPTSSEENMSHNTALDVKNYDDKGHEKPESVAKDAKVMEVWQHITDYTDLNACYSSPSQWNFRFLEITGQNCETHRNIEEICKRIPKLRIETKTRYVKPRVESKLRIDFKYKPPRKATKSLPKPHKEKIVSIKVLVPKPSDENLSRNCTCTCESPEEIGKRNDIRRSYEEQEEEDDDISFKELLDILFKYDKETHKNGSSNVICNLVKRFQGNSLLNEDEVKRVLKMLDSNNHIVQECLLILINKVTSTSTTAKLFLQNDVLNDLIYLMLMGSTDDVQLQAACCIAKLTEREEFSDLWMEAMAISGTEALFDVLSADEETVFESLRKAILDAVMNLAKNQKMAAMLINGFDLTKIIDLTRCKTDEGKVFGSPAIQKVAMGVLNSLLAHSYDIVEQFISKYSEAVDRVLDILQYSSCSQQQEAARFLSTLTLFPHGIDPVISHHATEHLLWAMTCSHCRFVRENTSKAFKNITQHSDKTKVLSALEQFSIAQIDQPYDSNRELDALRAQPTTTKIISDLQKHTSLSKLEKTMVDIFSVLSISFQTDSLHLCGTSRTFTNDSQGKDARNCQGISTKGVNEQYLSSLRVLVNILVAMATLICLKDRDESEKEIPCSLGNGANLSLAALFVQCGGLQFLNQLRFLTTKLQRVNPPSFHEIDPTTLPPKEIVSSIKNTRSELIFTASGQKRIPKNRYPDFGFHSAEIQFVGQAVEFLNLLVQVTTQDFDPVQEDLNVFIHNRSPPALSKRKHISFLSAALVVRSVIRVNGSISPRGGKEGNDNGNKKRIKRHSSRSLSSRTSHTTMERRSTTTSQVTKSSSSPSVLDPGTSSKNEMIHYVKQSLLAANVVSLLAVWVTCGVYDIQIGVIKVLRYLMHTYNPPKRVCNDQASHNQPQEAWATKTKKASKSTKPSQRSSLTQLNKPKNKSTQLSHLCVRHVIQYCGAYLLDLLEPPATRNLGRLSLMVIREAIVNGENDSRLNFVKLGCLSQVINYIRGTEDEPEIQSLGLVVLRSLVSNNQALKQLFLAHGGMSLVMALYEYKEGLVKEEAACTLKMFSRASADTGNKTKGPTAHSKKRSRTQTTNDDIWDHVTKKWEGQDKVAKVLTKFNVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6J5</accession>
    <name>A0A6P8J6J5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor AP-4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573513.1">
        <property type="nucleotide sequence ID" value="XM_031717653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6J5"/>
    <dbReference type="FunCoup" id="A0A6P8J6J5">
        <property type="interactions" value="2265"/>
    </dbReference>
    <dbReference type="GeneID" id="116307405"/>
    <dbReference type="KEGG" id="aten:116307405"/>
    <dbReference type="InParanoid" id="A0A6P8J6J5"/>
    <dbReference type="OrthoDB" id="10029128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11419">
        <property type="entry name" value="bHLHzip_TFAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573513.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30593" checksum="0E2C1D9A2551B6AC" modified="2020-12-02" version="1">MTSYQLAGGTASQDDTFEDPANNIDCSTSPESDRDRERRLRREIANSNERRRMQSINSGFQALRMLIPNAEGEKLSKAAILQQTSEYIFSLEQDKTRLLQQNTTLKRILSHCERKGQTKSEDSRLPCKRLRRASDTENTDQARAIPNNTIKSSTKDENDNNITEDSLLEDLQKELIDLRCQLEKERRLRISLEEQKQKFEADLNELKSKSHHNSNKALAATRQNLDTIVQAIKHLEGDGLECDETPIKFKSDVLGNNSEFTSRRLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6T5</accession>
    <name>A0A6P8J6T5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116307465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573593.1">
        <property type="nucleotide sequence ID" value="XM_031717733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6T5"/>
    <dbReference type="GeneID" id="116307465"/>
    <dbReference type="KEGG" id="aten:116307465"/>
    <dbReference type="InParanoid" id="A0A6P8J6T5"/>
    <dbReference type="OrthoDB" id="5959645at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="38"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031573593.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39863" checksum="B34F127E2B9BA1D2" modified="2020-12-02" version="1">MANHSNASTSSPLYFREAFEIQIQVFFLIIILVTTVVGNTLVIIIIWLDHRLHTPGFYFLANLSVADLLLGIVYSPFYISSTLDQKWLFFETWCKLHAVFISTCFNASLVTLSFVSLDRFMAITKPLRYQSLLTTRRSLVLIALGWVHSIFWAAAPLVGWGEITLDLKTNTCRPNWNAKGFPSKMYANLLAVFTFALPSAIMVYCYFRIFKVARHQVKLIKRNSIGSSQNGPQNSRPTETRALRTVLMVLGAFVLAWLPYTIVSTGKLFMKTGWDVGASTANAVLTTTLVNGCFNPIIYAMRDRRFKSGLQKIICPFARTNSLDLSSYVSSAQVTAHVLRQKELGVENVVQSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7R8</accession>
    <name>A0A6P8J7R8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">DnaJ homolog subfamily C member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116307128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573140.1">
        <property type="nucleotide sequence ID" value="XM_031717280.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573141.1">
        <property type="nucleotide sequence ID" value="XM_031717281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J7R8"/>
    <dbReference type="GeneID" id="116307128"/>
    <dbReference type="KEGG" id="aten:116307128"/>
    <dbReference type="OrthoDB" id="5960227at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573141.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27984" checksum="31E2095E8B0AFBC3" modified="2020-12-02" version="1">MQSFSTKCLGLRLHPFSVQYQCPLSSVSSRSYSSKDSKTHYEELGLPENATTAEIKKAFISKSKELHPDVNPLDPDLHKAFVKISAAYNTLSNPTSRRNYDMKLNSYSAPSSSYSYSAGSPFGTRNASHYYNNHNRWHESNKFHRTPVRQTPLRNPYNKYVVAGVLVFMFTGAVVHYVIFSFRHQKYKAHVEEASRKANLAYAESKERARSNGVRKQLDLLMALHAQPASSTLQHVSEVSNDSEKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J8R2</accession>
    <name>A0A6P8J8R2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 8B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116307969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574163.1">
        <property type="nucleotide sequence ID" value="XM_031718303.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J8R2">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="GeneID" id="116307969"/>
    <dbReference type="KEGG" id="aten:116307969"/>
    <dbReference type="InParanoid" id="A0A6P8J8R2"/>
    <dbReference type="OrthoDB" id="69646at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319">
        <property type="entry name" value="FIVE-SPAN TRANSMEMBRANE PROTEIN M83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574163.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38983" checksum="4B63C321B0874C6E" modified="2020-12-02" version="1">MYYITTTKFFSMKAYQILYNISVTEVGCSEALPGLTIANPFDPACVPVQEMSXTKTGKVLNVKFTTSKSNNSISLPVNRPMFFSLEVSPYHVGSMLSAHLALQSGSYDETLICLQKDFPPLFYQVESYYAINCSGQLSSVSENNRASSIHVPFPGEGIWYISLYTKASSVATIGFYAEMQACSSDCNNQGTCNIRTKPDIVFGECSCDAGYKGWACDQDNDVDLLRVMLLTLSNVAFLIDAGIALRKQLYPETLVYLFLLVISTLYHLCGSRVFCAMDEXFLQTCDLFAIVLSVWVTLVILTNHRXPAVTPTLNMLAVLVLFVSVQEAKRSILPFVLTVSLGVLLVIVYNVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JEL4</accession>
    <name>A0A6P8JEL4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P53-induced death domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574840.1">
        <property type="nucleotide sequence ID" value="XM_031718980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JEL4"/>
    <dbReference type="GeneID" id="116308534"/>
    <dbReference type="KEGG" id="aten:116308534"/>
    <dbReference type="InParanoid" id="A0A6P8JEL4"/>
    <dbReference type="OrthoDB" id="100767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00045">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="2">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574840.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55561" checksum="DFD0D31184A58033" modified="2020-12-02" version="1">MESQTELQSMKFQELLTKIGRKIRAHDVEIFINKLKVTERLPPSLLDDIDIRGKNSGLEFLKKLQKEGYLAKDNLDFLKELLLDIERQDLLQELLKFEKKIKTSSDVEGAVARETEGYNIPPPILDMITPGRPPYRDPRRPPTPPSPLYPPPESQIVKINVEGGFHDLSSFGVLLQVPPNAVTHPTEMICRKIYPDLLLCATEENETLVSFCVEFESTSLVQLQNPIIVTLAHSGPSKKEGYETIVKELRDSWKKWKQIKEIQEDYPLAHEHLNSAYICLEIMIGERKALAVVTRLITDTFEVTDKGCVVRSSVCEDVTLEFPEGAVDESSMGSLKLLLMPDHIDILDGMAAYPCPIILIDGFEGVNFATPVKIKLPHPYPEGYPTGNVRLLTKDAAHEWKDITNEVPCVETESFIELQVSHFSWLWAWTYEIPLTVASSFSRYLFKAPQDVCFAVFKKTELCSLLKAPQDVSFAVYTSLTMTLVCVPNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZL7</accession>
    <name>A0A6P8GZL7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase omega</fullName>
            <shortName evidence="5">GSTO</shortName>
            <ecNumber evidence="5">1.20.4.2</ecNumber>
            <ecNumber evidence="5">1.8.5.1</ecNumber>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116286219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="5"/>
    <dbReference type="EC" id="1.8.5.1" evidence="5"/>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031548536.1">
        <property type="nucleotide sequence ID" value="XM_031692676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZL7"/>
    <dbReference type="FunCoup" id="A0A6P8GZL7">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="GeneID" id="116286219"/>
    <dbReference type="KEGG" id="aten:116286219"/>
    <dbReference type="InParanoid" id="A0A6P8GZL7"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050610">
        <property type="term" value="F:methylarsonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031548536.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27471" checksum="A28EB40962CD5189" modified="2020-12-02" version="1">MADSKPKLYTAWFCPFAQRAWIAMLAKKVDFEYIEQNPYNKTPEWMAISPTGLVPVIVHDGNTVYESSVCIEYIDEAFSSDVSLLPKDPYQRAYARIWGDFLSKNVIPHFYAILLKQTEEEQNRAKEQYLDGIRKITAAMKPEGSYFQQKSLGYFDIMLAPFAQRMPVLKHFKGFEIPDTPEFARYHKWWESVKRHSAVVPTLRDTEDLIQMYERYAHNTTKSLVSQAVRKGQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H209</accession>
    <name>A0A6P8H209_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">unspecific monooxygenase</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116286970</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031549431.1">
        <property type="nucleotide sequence ID" value="XM_031693571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H209"/>
    <dbReference type="GeneID" id="116286970"/>
    <dbReference type="KEGG" id="aten:116286970"/>
    <dbReference type="InParanoid" id="A0A6P8H209"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF21">
        <property type="entry name" value="CYTOCHROME P450 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031549431.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59493" checksum="5AA407B4F6BBD4CD" modified="2020-12-02" version="1">MYSPPFMQFNPELPYSFETQLFFLLVSFLLIILIAHKHLQDLSIRSQYSLPPGPWGLPIIGAAFRIGSDNYKDFLKLSEEYGDVYSLYIGSRLAVVLNGSEAIHDALVKNSLVFAGRPDLVTMEMAGQGGRGILNATYGKKWQILRKTSFSAIHKYLTTKDVLYATLNKGRHHLIEQLHNNQATPYDVMSALKSTTATVILGALFGDDYCKQDVDKILALSDSFRETVGCGLAIDFMPWLKYFPNPQLDRLSGIMDQAKSVISKLYFENKSSYKRGTIRNLADSLLEGVNNLKDKQRQNPILDCNSNLVEGEGLPTDDLDSIMVLVDLFGAGFDTSSITLYFAIAYLVKYPHVQRKAQEELDQVIGRHRMPRVSDLDNLHYTNACVYELLRICALAPLSVPHSTTSDVIFRGYFIPKGTVVFVNLWSVLRDPKLWKDPDVFDPTRFLDDKGHVISPRRLPKFLPFSTGRRACVGRSLAEVELPFLLASLVHQFEFTSAESGEEKKKTVKTENGLTLKPAKYEVIIKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H676</accession>
    <name>A0A6P8H676_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Apolipophorins-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116289154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551894.1">
        <property type="nucleotide sequence ID" value="XM_031696034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289154"/>
    <dbReference type="KEGG" id="aten:116289154"/>
    <dbReference type="InParanoid" id="A0A6P8H676"/>
    <dbReference type="OrthoDB" id="6484170at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009454">
        <property type="entry name" value="Lipid_transpt_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06448">
        <property type="entry name" value="DUF1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0758">Storage protein</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028318772" evidence="10">
        <location>
            <begin position="17"/>
            <end position="2919"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="11">
        <location>
            <begin position="34"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="2388"/>
            <end position="2562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551894.1"/>
        </source>
    </evidence>
    <sequence length="2919" mass="336428" checksum="D4331E5AA60F57CB" modified="2020-12-02" version="1">MKALAILLALACGTLAAPRPMLMRPTCENSENRFIPNRKYVYRYVGMSTTGIQGTTDEKAEIKITARFHVNSVSSCVFHLEVDDVQLSERSSPDAQFTISKGKKEFVRDLEGNPLTFTSVNGQILDIKTSKAEPVYVTNIKRGMLSALQLEFKEEGESTVKERDIAGDCKTRYLRMIKDDKEDVYKVKNLTECTNRSNMDTTLMHPVFYTTGSGKRTPLDCTSLCHYKIEKKQIYSVECKETHLLIPLSYQSSGVMTTVTQKIVLEKMSFSGGYRSNLEDASSERSDLRFDFNVKEKMQEKLQGDTTSVDKILQDLVGNKTPKETSWMAPLAYTELVFQFRRLNLQGIKNTWTKFADCSRMDLCPTKQLFLNYRQLIVDALIQCGTESCAEFMIQHIRETPEWAYVFERGSETYRKQLLSGLSWVRNPTEKILDNVWTLMKEKKDILPENTITIMGSMMRTHCEVYPKNCKDDLSGLDHFPKVLEISRSFSSMLYMNLELCKATPETVDEIIFILRAIGNSRFVETSPVDLVYCALKSNYKNISAAALEVLGDLKLDYQTRKGLKTIYKDYAQDPEIRMMAYLAWMKEPTKEDIKTVMKTLQEEINTQVGSLVWSHLTSMNTSVEPTSGHSIGTMIEEVLRETQTSLRYFNTTSKSTVWHKSIFNEKNNLGMSADSHVLYHPESLLPRHTHFNFSVDVLGGAFPVLEASTRTEGLELLWDKLFGPRGHFPDTHISDLVKTQPKKRSLDDLNELQYLHDMVNMPRTSTPSGLFSIKLFGNELALFTLKDLKWLQHEVPMLDWVEMLINLRNGVDDMYTKHWLFLQDSFTIPTSIGLPLTLSLNGTAVGSVHVSAKGDLHSWFWDWRPSIKFKGSVKPSAAVSMSGMMSVNAFHSKVGILVNGTLFTSAKISANVTYKKEETFKFHYNVDEKPEEIFNMSSMLFKQVNDKKTPISGIKQRRKASVCISSIFNVNKYVGMDLCSNISVPISWDKTMAPFLPLTGPANFSIKLHRSDPKLTTYKLEVNKTKFSKSPNKTCLELSTPGSSHKRILLMNLTTLDQPDRFQLNISVGDHEANWTVLNFTRNSNSKMLMAEMNITLPNISLYHTAKVHEPSKIISTKTSLIRGPYGNPVTVMFLNANLDYSSRSTGSMIFNLMHRPLDFTWQVKVRHSSSELKTNILCVMKCRKRPSPLLNHRMEFNITQIDHVRMTSENITEKGLRVEMRMNETRRMSLFGSKKVVKTIGHKFSTYFTTFTFYNRTTLKPYTTSLNLTLHENLVTKWNEMALNMTYKNNSIALETSMKNTTEKKSICLIGRYLNGTSWNKTDFISCIAFLNGTEVKNLIWNLKSMNTTHKLNATWLRRPDVHMFVNYACKNESLAKLTVSYRKTNSMKFLGVNGNMGNWNMDLQHSFQDEVKMKTKLRRILIVHKAKNGTESYMYNAFNLTFLNSTTMKNMLVGLTLSTRTKDMLEKESKLPRQFVNRTASWKAEMKNDTEILNVSSLFDYQVMDQTEMPNKLILKKQMHHTLFWHKTNSLLNVSVDFPNTTLGLNCSGNFIKGINMSANLNDSLLWNAYITERKLISNVTLWNRTLMMESRTCNRSQSLFLNISTWNMVNRTAFNGSITWYLNATTKKTAINVMLVNVNAMLLNTTFVNTSLQFSAFALNDSHLNISFVRRNMSDLYKESSLEFRPGGRVYMEFNATSLKRIWRELNLETFDMPRKLLNITVNFTSRGVNMKKTGKHLKILMQKLTREISAWKFTQQNLGDNLSNLTKKLLKVTSHSLPDVTSDYDIYLKKNRSEIMKFWKHLTRTIVAIPRHEIKSKEMAKELIQSLKYISESFNKTSVIGNLSEVLSNIVLYNSSGKPSHLKNLTDNITFYLRNLTNDITYYLRNASKDMGSWKIHSKMVDSHIKEILPKVKDKMLYILNETEMVITEIHEHLRILRDDVAFLSDHFVNETYPEVYNKSNAFYNNLKMMASPTTFAGGIMHPCWMNISEILNTSIFNITIHHFHKYLIYGTALETILPFLSQPDHITEVFHESVLDRSLEKMLNNSLNKAMEMYNATLRLPSWHVNKTHDNIVYARDLVVMLYNDTDNVMTSISKKNLTEIVELYINQTRNMTVKTWNLTMSMMESILNVSIPVHGRFDMLKKNVTELYWNTSEKMPWARPLIRLWNTTMFSLAKNNTPERLIESWMPKIVNFTLNKASHFAKYVNECLTDEQTQTPRIQMAYSKKVLKVSTIHKMESRPNFTKYFLKVSRHYLSFSTWIFNMIKEPKRVMANSSNITMQWANVLFNGTSKVFDEAESVVNCSLVINKTNNLTNQYVKTSPMMMEVHTWVRNKTLEKMFNKTNIPYSTLLHSTLPYFMWNTIDKMRKMEAQDLAILFTPKNETAFVINQRNFITFDKRSFRVPEIPKPGCSFLLARDFLDGEFTVLATQNSYIIMTPELNIEIYKDGTIKANTAGQPQIVKTDLPVGFDSVYAVRDGPYIRVISDRRGFEFELEMEHFIFGAYISGFYHNRTLGLLGTNNGEISDEWRSPLGKNRTVLEFEKFLNSWLVSKDSECYIRRPVQRQQCQPKESSRCEELLKSKMSPFQKCFDVIDPKPFFEACIKDVTSSCETSEPERMSHCNVSAAYVRACVKNGVDISVPIQCADCNEQTRFMVSTREVDIMVISSEGRNMKQVTRNIPKLISRINMNLLNNNIRPQFGLVGFSGRQPLHWKGHTHTLNGKFLGSNIELIQASKTLDFASYDMNISDGYMGIYHATKYPFRPGAKKIFLLVTDSRRVKDSDLTSDFVSKAMKSIDAKLIVIGDYYFKYGMYGGDTDRYRYYRKDPEGSIRKNRQRLPEEDEYVKVVSKTEGAVFMVKRFEKDKTNKYFSEMIKNVMLKYSKGKRCMQCRCVPDEVGKGREVCKETSNFWCNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8L4</accession>
    <name>A0A6P8H8L4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116286675</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549102.1">
        <property type="nucleotide sequence ID" value="XM_031693242.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286675"/>
    <dbReference type="KEGG" id="aten:116286675"/>
    <dbReference type="InParanoid" id="A0A6P8H8L4"/>
    <dbReference type="OrthoDB" id="377549at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040346">
        <property type="entry name" value="GEX1/Brambleberry"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33538:SF2">
        <property type="entry name" value="PROTEIN GAMETE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028130079" evidence="3">
        <location>
            <begin position="22"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549102.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="62078" checksum="E8E9F1A71ECA2061" modified="2020-12-02" version="1">MLATNRFVIILLISVFLIASAFEMPSEDRYKAGEKSLEDFQTRARHSDCWKKAIENLEVGCKKLTDIEQSYLAVAFTNCHXKKSGKRTYNCSRDKSIEECTSGMDDLAFNAYTTFFTHTTNICFYLQSQAWQERTEDTVSKLSQTSEEVAGQLENSIKNQLLVLKHQNQSLQNQKRIIVHEQKLSMTLKSSTSEARQAFDEMKTKANEQRAIFTDTFDGIFKSVESIKQLQAMILGEFITLQSLAFHFVAICVCYFFTSSPRTANARLALFIGLVALIGVERIITSRSIGDGDSMDTEVVHLRLWMCRKIFFLTASVGLLWVAYKYKDFNKINHNMLLEIQKQIRDLKYLQSMDSNIKSITEGTSVPMTALTASKSWAGSQHRNTQKATDYPDSGDIVEVEDGYDETYVQQENDDESSSSSDYESLYSESIADLSFSNGSFMVKQGIENETSTPTKSRRKSGQQVSTPRQSGSRSQTSRSSLTPSHSYNLRPRRSGQFSPNSSSFMNMPSPSTLEDLVKSLKQNTARYTAAMKKDKISGKQLFSSDDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H952</accession>
    <name>A0A6P8H952_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116290102</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552954.1">
        <property type="nucleotide sequence ID" value="XM_031697094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H952"/>
    <dbReference type="GeneID" id="116290102"/>
    <dbReference type="KEGG" id="aten:116290102"/>
    <dbReference type="InParanoid" id="A0A6P8H952"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001325">
        <property type="entry name" value="zinc finger protein 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000345">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF35">
        <property type="entry name" value="FEZ FAMILY ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="232"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031552954.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="58192" checksum="2B34F4B7E7DCF5FB" modified="2020-12-02" version="1">MTSYRPQHRFYASKLAEENRLHSLRNGCGSSVHRPTPIYLAPGPLRVLQEDWALEAQMTPNTLPSQASKEMVEKGDVCLRDKTSEIKDKRQDGGHQRFKEIGSRHLSAFSSKRKETVQSSRNDERMSGLQTEAVDEKLRGDKQRYQVTPGALNPDDKDDKNTWNNECNEECFNAKFKIKEEPLNSPIDSEPNSVDKDPVHQQEEFSFRVYGTDHALLLPQIPSEVPTYAEHRSFSSSVQTTDNSAGARSLNFNQDPSSTKFQSSGKDSSVEGNQQQKPKHICDECERSFTRSSTLVTHKRIHSGDKPFSCEVCGRAFRQPGNLSRHRLTHTTTKPYVCPHCNKAFNRASNLHTHMRTHSDYKPYACDFCDKRFHQKVDMKIHRYTHTGEKPHKCSKCGRGFKQLTHLTYHMRTHSDVRMYQCEFCGKGFNQKGNLQAHRYRHTGERPFKCNVCGKGFTLASTRNTHLRTHADKKPFECQYCGKAFYQKNALKTHYIASHPYSGGVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9G0</accession>
    <name>A0A6P8H9G0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116286685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549110.1">
        <property type="nucleotide sequence ID" value="XM_031693250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9G0"/>
    <dbReference type="FunCoup" id="A0A6P8H9G0">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="GeneID" id="116286685"/>
    <dbReference type="KEGG" id="aten:116286685"/>
    <dbReference type="InParanoid" id="A0A6P8H9G0"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="97"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549110.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27758" checksum="BA0114F0BABB16AC" modified="2020-12-02" version="1">MATGCSSLSTDLSAFRVEKAPDSVYYMPNFITTSEEGDLLREVYAAPKPKWTSLSGRRLQNWGGLPHPKGMIQEELPQWLKKYAVQLGSLCVFEKKIPNHVLVNEYEPGQGIMPHEDGPLFHPVVSTINLGSHTVLDFYTHVREKDDSQEIIQQDGSTETNSSMNARHVMSLLLEPRSLLILTGDLYKNYLHGIEEKKYDSIDNRIKNLELCQAKLGQTIERSTRISLTIRHVPKTLKLKLKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9U2</accession>
    <name>A0A6P8H9U2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116289199</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031551938.1">
        <property type="nucleotide sequence ID" value="XM_031696078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9U2"/>
    <dbReference type="FunCoup" id="A0A6P8H9U2">
        <property type="interactions" value="3322"/>
    </dbReference>
    <dbReference type="GeneID" id="116289199"/>
    <dbReference type="KEGG" id="aten:116289199"/>
    <dbReference type="InParanoid" id="A0A6P8H9U2"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16626">
        <property type="entry name" value="RING-HC_RBR_HHARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031551938.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="59354" checksum="64F85DCB2F21F6FB" modified="2020-12-02" version="1">MDSGDDDLLYEEDDSVGDWQSEDAEHSDFDIDCEEPSTPKRPHLNDDFHYECLSPEALVSYMNEIIDEVNSVFQLPRPMARILLSHFKWDREKLLERYYSGNQESLFSEAHIVNPNTSKSSQSTRANTRSQPTEILCDICLSLIPAGNFTGLECSHKFCPRCWKEYLTTKIIDEHMGENISCPASKCDILVDEAFVGQILRDPKVKTQYHHLIANSFVVNNRLMKWCPGPDCHNAVKANYHDALPVTCLCGYNFCFGCSEPVHEPVKCQWLKKWIKKTNDDSETSNWISANTKECPKCNVTIEKNGGCNHMVCRNSSCKADFCWVCLGPWEPHGSSWYSCNRYDEKEAQSARDSQSRSRAALERYLFYCNRYMNHAQSAKFESKLYAQVKQKMEEMQQHNMSWIEVQFLRKAVDVLCQCRNTLKYTYVFAFYLKKNNQSVIFEDNQKDLEMATETLSEYLERDITQESLSDIKQKVQDKYRYCEARRKALLDHVYEGYDTDIWEYIDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA56</accession>
    <name>A0A6P8HA56_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289650</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552456.1">
        <property type="nucleotide sequence ID" value="XM_031696596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289650"/>
    <dbReference type="KEGG" id="aten:116289650"/>
    <dbReference type="InParanoid" id="A0A6P8HA56"/>
    <dbReference type="OrthoDB" id="5970528at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUEL-type lectin" evidence="2">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="2">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552456.1"/>
        </source>
    </evidence>
    <sequence length="1452" mass="160967" checksum="629BDDD8F8FF8B88" modified="2020-12-02" version="1">MTKFGENRWVFVFTDISVSHHIVPHAGIRPRSEIDLTTDKQVLLCAGQNKSLECVSPGSTIAIMDTFWGRLSDKICPSEDGDPTTSCGNDLSTTSVLKNLCDDKVFCEIPARHRVLQAPGTTHCPGVNKYLIVNYTCMPIERKFVLCDGETTNLKCGEGWKLNVLSAVWGRISPATCATTLGRPSRLGKCDSSNSTLARIRSICHGSNGCVVRADDEHMVQGNEQHCPDVDKYAMITYRCQPNVEQENVLESSKGSSDRIFLPENPTKRIPFLNQDSHANSDTHYLLQATMPNNQKHDNDPIMNSSLDGLLKEYMESQNNRGGDGTTGEQMNIPHDTRPSPLKERLGVPQDGAKETLQQNIALLKKILHSKKIMKVGVNAMEGIDMASAVSEPRNPNSNNDELSNQLDLTRDELNHLAESPDAIKIINEYMSRNITASNHDTQGSQETSTSKTTSPPSNTNKTVGSSEREEKLTNMDGKQHFEQVSSTTTTTTQTPLPTISTLGTTIKTTQKDLSKLIEPTAKLGGKVMGNMFYEKFLKPAQNDFEKQTKNIEQNTEGKAIGLLRKKVSALQAISDALTLITSKIDPDQAGGKRHHSARNNKHREEIKWLQDLPDSVQPKDVQFLQDKINKAIETTEAMERQAALKNPSKVALRLKGKVAEDVQAEARNKVQQRKERLRIDKQIKDIEDSFNMLIEKAEKTGKFSDVDVKMKPTSSLFQELQSGALKMPFNDEQPHGGDTDNSTKGVYGFEVVNQEPVINIINEKDNTVKSNTMDTSKSSSTTIQASQTTAETNNDNHTLLSATHLPNQSKEQVSSVTKLAPKTAFKAANSIANALRRQSSIQNLSSVALKPISTFNNIQDITLGGRINSEVIKEKEKEKLYQGKDVNVLLNMIKAPPSKTSGNRALGPPNQVPENSVTFTGKGVLVPGKDLQVPGQSIRKPGKDDKVPEVQTVGSLDENSVKLLSVLVRGFLDQNKSRKSSKHHRRRKKKKEQLEEEDFVIGAKHYQIGNNKNNSPDRELLDALENQLSSAQRYSYNIKNIVSDAQATKGEDDDTVKSVPNDKEKEIVEDDSLVLSSPTVKPMPAPSDDSSLQLVNKYTGESSLDNLLLSLQKMLKQGEIEFQKDKKKGILPAQESIAENASKTFLSSKPRVVQFSGAATSGKILNPVDERKMTANQDLQKITQFAGGRILEPASSAGMLPIQQDTISIINANPTAKSKVGSAQINKPTSKLRLKNLVSGVKLLLKALRGKSLDSYKGHHQRRLEDDTSDQDDKDDTPEDFESKPNDDLLKDKEKAEQPVNYNGFGEYVGPKNKGTSTWYIGEGNSYKTGFQQPKGYQYDEQYEMNLAQRYASTPKEYSTFIPDIYSGPYTSFALQPNTYGYSPKKAFHDPFDKQYASKLPNPARHALNSALKNDPIIQAVEEFSDNETQLYNEKLRGIQKDNIPRKQNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBA6</accession>
    <name>A0A6P8HBA6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="5">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116289602</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031552408.1">
        <property type="nucleotide sequence ID" value="XM_031696548.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HBA6">
        <property type="interactions" value="1804"/>
    </dbReference>
    <dbReference type="GeneID" id="116289602"/>
    <dbReference type="KEGG" id="aten:116289602"/>
    <dbReference type="InParanoid" id="A0A6P8HBA6"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000013">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000019">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000012">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="13">
        <location>
            <begin position="466"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="13">
        <location>
            <begin position="762"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552408.1"/>
        </source>
    </evidence>
    <sequence length="983" mass="110596" checksum="91C737679B8068FC" modified="2020-12-02" version="1">MVMGTAILDNSATLAEIAHREYQTGNYDRAEQICMQLWRREPNNTGVLLLLSSIHFQCRRLDRSAHFSALAIKQNPMLAEAYSNLGNVFKERGQLKDALNNYRHAVKLKPDFIDGYINLAAALVAAGDLEGAVQAYATALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKSIETQPSFAVAWSNLGCVFNAQGEIWLAIHHFEKAVQLDPSFLDAYINLGNVLKEARIFDRAVAAYLRALNLSPNHAVVHGNLACVYYEQGLIDLAVDTYRRAIELQPNFPDAYCNLANALKEQHKVGKAEECYNTALRLCPTHADSLNNLANIKREQGKIEESIKLYCKALDIFPEFAAAHSNLASVLQQQGKLQEALLHYKEAIRIHPTFADAYSNMGNLLKEMQDIQGAIQCYTRAIQINPAFADAHSNLASVHKDSGNIPEAIQSYRTALKLKSNFPDAYCNLAHCLQIICDWTDYDTRMKKLVSIVAEQLDNNRLPSVHPHHSMLYPLTHEFRKAIANRHGNLCVEKVALLRKPKYTYPKDLXESGGRLRIGYVSSDFGNHPTSHLMQSIPGFHDRSKVEVFCYALTPDDNTSFRKKISQETEHFVDVSSMACHGEVADRINADGIHVLVNMNGYTKGARNEIFALRAAPIQTMWLGYPGTSGAPYMDYIVTDKTTSPLDCAEQYSEKLAYMPNTFFVGDHKQMFPHLMQFLRTVSNDGTVENVPNGFIQPHTLSRLLNGEINPNLFSRIPSFVEAKKQEYEGCKDSGEKIPNTASNTCRSQYGLPEDAFVFCNFNQLYKIDPKTLKVWANILKRVPNSVLWLLRFPAVGEANIKAEMTSEGVPENRVIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTCMDVLWAGCPVITLPLDTLASRVASSQLTALGCPELIADSRSNYEEIAVKLGVDKVYYEKIRIKVWKNRFLSPLFNTRQYAHDLEDLFLKMWRRYEKDAEPDHLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBY0</accession>
    <name>A0A6P8HBY0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289810</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552633.1">
        <property type="nucleotide sequence ID" value="XM_031696773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBY0"/>
    <dbReference type="GeneID" id="116289810"/>
    <dbReference type="KEGG" id="aten:116289810"/>
    <dbReference type="InParanoid" id="A0A6P8HBY0"/>
    <dbReference type="OrthoDB" id="5947358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552633.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31974" checksum="0BF38CFC03AD53B1" modified="2020-12-02" version="1">MDAFRVNRFGRTYRTGVALDQDMRTMIIDRILQEGGDRATGYIPRSLRYFSEELQLSYNTVAKIWRQFCEEFSIDSRPKGGTKWSKLSEDDLELIELLKIEKPSISLAEIITCLDEMDGVDVSMAAVSRAIKQRLPSGPYTRKKITKIASERFTATNIFYTQLFINYLATKDPRRLKFFDESGIKLPDVGTRLYGHSSAGTRCVEVTRKAESPNTTLNMLVSLNGPEYYNLIDGATNTLHFLEFFEEAGNCVNLQFGRPCLQVGDIIVIDNLSAIISKGEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBZ9</accession>
    <name>A0A6P8HBZ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chymotrypsin-like elastase family member 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550202.1">
        <property type="nucleotide sequence ID" value="XM_031694342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBZ9"/>
    <dbReference type="FunCoup" id="A0A6P8HBZ9">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="GeneID" id="116287656"/>
    <dbReference type="KEGG" id="aten:116287656"/>
    <dbReference type="InParanoid" id="A0A6P8HBZ9"/>
    <dbReference type="OrthoDB" id="6021267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028162948" evidence="7">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="8">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="221"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550202.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51537" checksum="623778A21BFCFD35" modified="2020-12-02" version="1">MSLTSLLHVLLVGLSCFAIAVSAVPGDCSFDFDLCGYQQDPNDNFDWRFMTGSTASPSTGPQSDHTTGRGWYIYIETSSPRLNKEEARLISPPISNTNGNCLAFYYSMYGLNVRTLNVYTQESSGSRTLRWSLTGDRGSHHWRFAKLALPSSRSNLRIVFEGLSGTGFRGDIAIDDVKVYNAPNCAVVPQGATPQPNPQPTQPPSPPSVPSCGIKPQGTRIVGGYEAAKGAWPWQAMLLYQTASGSWKQFCGGTLITPEWVVTASHCVNDVRNVEVPYHRIRMGAHYLRKITGTEQDFDIERIYMHPDYNRYPSQHDNDIALIKLKRPAMLNKWTQPACLPTDSVQFAPGKACYISGWGHLKSGGDSPNALHQAKVPLITKAECTKPGSYDANKITDKMQCAGYPGQGGVDTCQGDSGGPLVCENNGKWYLVGVTSWGYACADPRYPGVYAKVSNLKSWVHHVIAYPNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDG7</accession>
    <name>A0A6P8HDG7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288097</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550697.1">
        <property type="nucleotide sequence ID" value="XM_031694837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDG7"/>
    <dbReference type="GeneID" id="116288097"/>
    <dbReference type="KEGG" id="aten:116288097"/>
    <dbReference type="InParanoid" id="A0A6P8HDG7"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550697.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11761" checksum="46305C933587A775" modified="2020-12-02" version="1">MKIIVSKDNNNNYNIQAAAAAAAIAITTEEGKRSPEELNESRTEKEQLKDDTTISSCDNNREEIQQTLQNNLSKAQTWLSLLGVKIDRHSSGTSTDYALFQENVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDI7</accession>
    <name>A0A6P8HDI7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290780</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553741.1">
        <property type="nucleotide sequence ID" value="XM_031697881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290780"/>
    <dbReference type="KEGG" id="aten:116290780"/>
    <dbReference type="InParanoid" id="A0A6P8HDI7"/>
    <dbReference type="OrthoDB" id="5987889at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553741.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33081" checksum="30700FE538F38F80" modified="2020-12-02" version="1">MILHAAYAVRESPTSVIIIQSPDTDVLVLCVSHFSEIECRKLWFRTGLSDRQRXIPVHTIQQSLGERLCQCLPAFHALTGCDSTSSISHRGKKKPWIALKCSATHQITLSLFGQQPDLDDTLAEKTEAFIRDLYPNTKRSTSTMDELRYLMFCQRRKRRNEALPPTSDSLRQHMKRASYQTFIWRSSLIAMQDLQSPEGHGWEIEDGTLKPVYMTKDPAPRSLVELTTCNCKKSRCQGNCSCYNSGLSCTEACFCMRDETCNNPHSTAEQYYSDSDEGSDDDLEDDSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDQ5</accession>
    <name>A0A6P8HDQ5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetylserotonin O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hydroxyindole O-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).</text>
    </comment>
    <dbReference type="EC" id="2.1.1.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031554554.1">
        <property type="nucleotide sequence ID" value="XM_031698694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDQ5"/>
    <dbReference type="FunCoup" id="A0A6P8HDQ5">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="GeneID" id="116291521"/>
    <dbReference type="KEGG" id="aten:116291521"/>
    <dbReference type="InParanoid" id="A0A6P8HDQ5"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017096">
        <property type="term" value="F:acetylserotonin O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554554.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21400" checksum="BB7972214B7F2B5C" modified="2020-12-02" version="1">MRGKVKLFAPIFMSSFDLSRFQRMCDLGGGTGNVAYAACMAYPNMKITVLDLPSVVQNAPHFRPSIHECPNQHNVTFVAGDFFEPTLPAADLYVLTHILHLFTDDKVDTLLANIFANLPSGGGVLIGEVLLYDDKLGPLYSQYMSLVMLLAFDGRERSGLEYKQLLEKHGFKDVQWKYTHTNSLDAVLAIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE44</accession>
    <name>A0A6P8HE44_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116288213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550835.1">
        <property type="nucleotide sequence ID" value="XM_031694975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HE44"/>
    <dbReference type="GeneID" id="116288213"/>
    <dbReference type="KEGG" id="aten:116288213"/>
    <dbReference type="InParanoid" id="A0A6P8HE44"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028174994" evidence="4">
        <location>
            <begin position="24"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="5">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550835.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50664" checksum="FED3335F62B24BA0" modified="2020-12-02" version="1">MFCKLFVFGILLIFQQNFKHSFSSPLKSFDPFDFLGIEESKRSEREGQCPVFPVPNECPPRGEDDACKIDEDCSLPKKCCSDGCGKICIDPENDSACKDLRQDCDSIPLKGDKLTEYCEKWKKNPAIRQCKKTCGWCKPPSPTVCEDKRDDCKWILNNAGHYLPEYCQQHKDDPAVKECPKTCGFCKLNVLKKGIKSNQNLREIIDVVSIGKKIPSPTKKFPTQPPVPQTLPKITEQPGVKPGPKPTNKPQGNKNLHVQIFGLLLIASQPRTDVILWYIRRVQITGFQKECLEAHNKYRALHGSPPLAWSAELTKDAQEWANYLARRNKFYHYPGLRKLDQGENLAWFSPARKECDGPSDEKCVHCGEMVKDWYNEVVDYDFKQGKGKSPYDVVTHFTQVVWKGTRELGMATAIANNRLVAVARYRKSGNIGSPEDFKNNVLMPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEF4</accession>
    <name>A0A6P8HEF4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysosomal-trafficking regulator-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551007.1">
        <property type="nucleotide sequence ID" value="XM_031695147.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HEF4">
        <property type="interactions" value="1104"/>
    </dbReference>
    <dbReference type="GeneID" id="116288371"/>
    <dbReference type="KEGG" id="aten:116288371"/>
    <dbReference type="InParanoid" id="A0A6P8HEF4"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1837"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1952"/>
            <end position="2251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2463"/>
            <end position="2504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="895"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="976"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551007.1"/>
        </source>
    </evidence>
    <sequence length="2668" mass="299183" checksum="0FCF965C74835AEF" modified="2020-12-02" version="1">MCYQDVLRSNDTSLRDLQSIVLDLFVHLANHQIRASELKDFIAIFKTKPVPVDLLCNSLAHIASKASFTHGPAYILSFPCRLQTVDPRSKHGGRKAKVQRLRPDIKRIKGGALLQSLGDASSEGANSEGSLSRIGKNSPERARRSKPQSKLARGGSVETSDRQDIQRSEAXPGDDTADLPSPFSVKAINLRCHGNQTWPPPDFSIVFWMRLHSLRRFSESEPGMSREATRLRGVTIPPVRGTRSSRSMSCPNVWTRGTDTPSCDEAIHICSIGSRKGLFEIWVLPSGGSLLFRWTKATKGGTDGYDIVKELVTRIPGLSRGRWHHVVVSFSQSKQRYIPPNGGMETKEYDDACKILSIVDGTETTEHNFGPPLPWYEEGKCTLSACLLGHVILSTAKKEGHGAEKSVLPEGYDLGNVLAFIGGTSIKSVKKGVATHGDWVVGKDEAFYLYSLGPNYNSIGHLHADFSYVPKDHQDSSQPFLVASRLWSRLSITERSVSAGLSTGFLRSPHVFIPDLETSLKSKLLLSYTPVRHTVFNQNIRIPTTDDKPRRASHLDVTNKPTVKTNLVQNEAKLFLEVEALRVSTFLEAAHDVGGMMVFIYLFAKVVEMTNDHKTQADALSIVLSLQKTCEYHARAMDEESGYALLKRILLSPQCMIGYHVLKVLMEAACDGEVFKHTNLSDNPIMLNIDSNAVVRNVDIFQHYLLNRNIWDKAKQGVLXMLLSTLEILVHASHPHYKFNIAQFQKAELVQQLLIGCQERQGEGLKEIPSTISTLYVNIIQNVMGQTPDLTVLKAVCEFLIAIHPTEDTTSLHSPNRFYLMEYEFDFGYPTPAVTRLPLSPSSFQRDSLLMAKKLSSPSSPYDSTLVEPKPTHSDDILLENLETSESTLRLGRNGTLIGEDRKEGEKERIGGSISEQKDKGEDNEGKCVQDMTIGQKGDKYEAIKEESPDVSVPCTTLSAEYLEFPAHSSPQAIAPHFASCPPPSKHRKLTVQIPHHPASSSVKPCLGSADGSSILLQGSPLREWKSSVSSPSTPQTPPTPHTPHTPVESYRGPGSKPLSIGIHSNTPQSRMSSVDVMEYDFINESDFSSLKSSLAHQSSMDEYLVVEGYPGIKSSTQTYKPNNSEKRRRAPDHMTKMRLGLLKLLQKILLNLQAEQVPAVIGGVLKAEYLLVWVSHQSDSVRELVIKILCLYLQKAEPERYNHFLGIHGFHLLANQLYDHTVTKGTIEACLWLMVGRPVDLDKDYAYSTAFDQNLSSILRPLGVVPLLSVLENTLISQNLNRMLIKHLCQLFLKIDDLCLNAVAHGLLQTVCNVVCGLARLQHQQSQGRTPITVDVSCLMDDLQTLISCIVIKACSTCGSMYFQMFEDLLVVLENLEELDHRKREHGLSIFFIARYLRYFAIQVALYFFQEICKDEIPINGRKRGGIRLFRGSEKSSDLNPFKPVSSWIPLSPDHNLPCSDLGFLKTTPTSANFNEQTQRFQSVIQMAVNCVTYSRTVFLNDALGPLQVYTADLQVHEALRPGILKGATNGVNMDKEFAQFIFSLLFEFLDTCLDNKGTMPSKVMFMSKEVIKSQLGKLLVYLLSPSQSLDLSCFVLQISDHVRAKKLVHAVLTSSGGGKLRDKIQAYLPKLLSMERLSEDQASNALSFKSLLEACGLRFAALNESSRTDVETQSWDHAETTNIMEWQKKRQEAFAFISKRIVALSSKVSESARIVTRVAVEIQDTQRQTLLKHNRDGLSAEVQIRKKWRQVIERVIHERSVWYDREYFPVSWRLDPTEGPLRVRCRMQRCHLDVPQKYVMKGHQKHATAQSGSPLAYLFEDSTSCHKKNVYYIFDTPDTIRFLYHCMHILLDIKTTGVILIGEIHMYFIGEEATTTDTDVTQILLGNKDAISISWAINEIQEIRTRRYCLKDIGMEIFLSNGRTYLLAFDSEKDREVVIEEFKQRRLPIYDTPISDNLNATTAKWRTGNLSNFEYLTELNKMAGRTFNDLMQYPVFPFILSDFTSEVLDLNDSKVFRDLSKPIAAQSINKETSYKERFRWLKEEYERSGQNDALLAPYHYGSHYSNSGTVLHFLVRLPPFTKMFLQYQDNNFDIPDRTFHSMATTWRLSSYESSTDVKELIPEFFVLPEFLXNFEGFDFGLRQNGERVMNVTLPPWAKGNPRLFILIHRQALETEYVSRSIHSWIDLVFGFKQTGTEAVEAVNVFHPATYYGVQVSSITDPVRQKALKTMIETYGQTPRQLFNYPHSPRLTRKISTSPAEFGSVTSLNTSKFDFEVASATNLFMHRFTGSFSSENTLMGSVTDTLVDAPKPVTTVEGLRWGSYVCSPALPVPFISFNQQIGFPVXSLVCNRGEVVHVLCKDTTLMSGYEQYPEERGERLVLSAALSXSAVDGSLTVFVEGSGSGAWLMDTKTPDKVTCCVTSIGCTSLFIGSSSGALFCLPTKYNPTLDCRIEVLGTRVRLYGHTDEITCLRICHEYSVLVSGSKNGTAIIWDLNRLSYIRTLDHKRAVDVLAISRTSGDIATVYHYGESLDQDSIHEEGSVLSLWTVNGIPVVHSTCEHTINCMDFSRAPEGVSVNIIATGLSNGAIRLWSTWDLQHIRDIAPEQNLSPIASVAFSEDSQRLFALSTQGRLIVWQRKDKTYGGRPPIVVTFPVSYTTPKVSQDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEP9</accession>
    <name>A0A6P8HEP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116288408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116288408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551055.1">
        <property type="nucleotide sequence ID" value="XM_031695195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEP9"/>
    <dbReference type="GeneID" id="116288408"/>
    <dbReference type="KEGG" id="aten:116288408"/>
    <dbReference type="InParanoid" id="A0A6P8HEP9"/>
    <dbReference type="OrthoDB" id="10051448at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031551055.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30535" checksum="1407B1C55C1F2201" modified="2020-12-02" version="1">MSCVPLCLKKAVVTLLLKKPHLDHEIISNFRPVSNLTFLSKVIDGINKQKIISPFLQQESGGKEECSKELNKNSLTNTLKEYGVGEEFSELMPVNRTILVTPCPHVDLVGMLWHWTQALWRKVQALGLATAYKKDDGTYKFVRRLMALPFLPSSEITRIFIRLLPEATTEGLQALTGYIRDNWIESTVFPPENWSTYGQVVSTNNGLEGYHNALNCRASGKVHFPFYMLGQYLYKEANLVGLQIKLVSEEKLKRIKRKKYCNLQWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF77</accession>
    <name>A0A6P8HF77_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116288561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116288561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551225.1">
        <property type="nucleotide sequence ID" value="XM_031695365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HF77"/>
    <dbReference type="GeneID" id="116288561"/>
    <dbReference type="KEGG" id="aten:116288561"/>
    <dbReference type="InParanoid" id="A0A6P8HF77"/>
    <dbReference type="OrthoDB" id="5987789at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031551225.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="31845" checksum="E06C9702BA7857BB" modified="2020-12-02" version="1">MVLPTLILQKPSATSKSKEHSEAIERRLSLWRAGDLSLLLKEIRFIQSRFSKTRKARSMEDISKIFANLVMQGKLSAAIKLLDRETSTGVLTLSPEVLEELKQKHPSAADIEDESLLNGPLELNPHGIFDLIDEQMIYNAAMRTRGSAGPSGMDAELYRRVLCSKNFNAEGKLLREEIVIMTRNLLKSSYHPILLESYTACRLIPLDKNPGIRPIGVGEVLWRIIGKTVSAFFKELKQAAGPLQVCAGHSGGAEAAIHAMSQIFSEEDTDAVLLIDASNAFNQMNRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF95</accession>
    <name>A0A6P8HF95_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116291991</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555084.1">
        <property type="nucleotide sequence ID" value="XM_031699224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291991"/>
    <dbReference type="KEGG" id="aten:116291991"/>
    <dbReference type="InParanoid" id="A0A6P8HF95"/>
    <dbReference type="OrthoDB" id="5973146at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555084.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="87655" checksum="13EEC6D2E96FE8D6" modified="2020-12-02" version="1">MAAAHEYSTEELNYFRICNVTTRIIAEGLRVVFKLLWDTHYQATHGPWQDTAKNGIDLYSMESSKSCKRNSRELLILRNGNRLEWDCTSLFVAILYSDSIGKGLDPVVKKAVDDLRRFRNKVFAHLSDGKLREMDFETSIQKVIDAFIALKLDTADIEAIKNQKTFPTEELRLTQQQLEKEKKRNEEPRSFCVLPPKPSHEVIDRSSEVDVILQKMKELRSTKINEITVVYLSGNPGCGKSEIARQIGEKVFDDVPDDATDQVKFVFALNASSTDTLIQSYIEFAITLNCDEKSTTIIGTSKDLSPEDKLIHLKTLVAPKLRMYSSWLLILDNVTDVKSVFRFLPKAGEKTEGNGQILFTTQDSQSIGANNSYTYHLSLSRGMKPDEAVKTLSEISGVASNKECILRVAKALDFQPLALACAATYMKRVSDKTSISWEEYLQKIQQGKREATEGEYKRISVTYSQSMTAAVKLALEKEMAADMVMMHAFQFLSALGPERIPWEYVVEYVTRCMTDQDEGVVAATVFSSSLILNYSEGQSKEIGIHQVXHSCLQDIVLHKSKKEEFHFLVNVINAFSALLKAFDENNVNHITTTKLVAVHFMHFSKHLTNFTTESLSPIKQKTNFEQKQNEYVSYFSAAGDVCQTHAKHEAAKTLFKTVLMIKEFYHHCNHPTLAPTLTKIGLTLFSLGKHEEAQELLERALTIAEKSFGQNHLKLATTLNNLGSNLIHLGKNEEAQLCLERALTIQEMAYDQNHPTLATTLNNLGSNLIHLGKHEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGV2</accession>
    <name>A0A6P8HGV2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Sodium/potassium/calcium exchanger 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116291183</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554173.1">
        <property type="nucleotide sequence ID" value="XM_031698313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGV2"/>
    <dbReference type="GeneID" id="116291183"/>
    <dbReference type="KEGG" id="aten:116291183"/>
    <dbReference type="InParanoid" id="A0A6P8HGV2"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF73">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="19">
        <location>
            <begin position="59"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="19">
        <location>
            <begin position="343"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031554173.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60539" checksum="00D92ABFD397552B" modified="2020-12-02" version="1">MEELVRHERKIALLHLHHHPRPHFFNCTFTKHSVISVLHYNSLFTLEERRNGAVIIHFLISLYCFTALAILCDHYFCASLEKLCKRLRIPTDVAGATFMAAGSSMPTLCIAIASVFMDEGDIGLGTIIGSTMFNILFITAVCGLCAGMVITLHTWPLIRDSFVYVVHLTGLLIVIQDNVVHFYEALLFPLLYSSYVVIMVFNTRLEKLFEKMCGSYCKYFRIHKGMEMVEMEDPRDFMNCNETPKDQDATENIENNVEDKILEEKESQEHETEKRSKHEEEPKSNFEEESEGTSHVHGFKPSSPFHMPEPLLKRSLWFILLPLHAIFYVTMPDCRKKEWESWYPVTFFLSIVWMAMISYVLVWTVSIIGETLSIPECIMGLTLLAAGSSVPDVVSSLVVAKHGMGDMALANCIGSNIFDILCLGLPWFLATTVVHPHSVVLIQSGHIIYTALCLFGTVFITLIAIHLNKWNLDKRLGCVLLFVYLLSLSVAVLLEALPGGPGGHGHEAKLIPHHPGHVPRKGLGHSRHQASANALHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHT9</accession>
    <name>A0A6P8HHT9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein F54H12.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116291498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554528.1">
        <property type="nucleotide sequence ID" value="XM_031698668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291498"/>
    <dbReference type="KEGG" id="aten:116291498"/>
    <dbReference type="InParanoid" id="A0A6P8HHT9"/>
    <dbReference type="OrthoDB" id="6109579at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554528.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29555" checksum="1151225FD6B89CDA" modified="2020-12-02" version="1">MIGRIHEDVFNIDRLMINGVDLRLKLTXSKNEFCLLSSATGANFKLVIEDAILFIRKEKVSPSVMLGHAEALRKTTAKYPIKRMDFKVISVPRGALNSSQDNIFNGQIPKRIVVAMVDNDAYSGNYKKNPFNFKTNDLSFLGVYVDGEPLPSKPPQPKFDPANGLGFIMAYQSLYSGTGSMFEDHGNDITRDEFNQGYAIFCFDLTPDLSNGAHYNLIRKGNLRLEIQFAKTLPVSTNVIVLAEFETLIEVDNQRNVLFDFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI25</accession>
    <name>A0A6P8HI25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Trace amine-associated receptor 7e-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555516.1">
        <property type="nucleotide sequence ID" value="XM_031699656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HI25"/>
    <dbReference type="GeneID" id="116292357"/>
    <dbReference type="KEGG" id="aten:116292357"/>
    <dbReference type="InParanoid" id="A0A6P8HI25"/>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555516.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39023" checksum="8B0E84412B7B6513" modified="2020-12-02" version="1">MSSNNSSLFINAFQRENNTHVHLQGFEIRILTRCFFFVTMIIAVTGNVLVITAIATSTKLQSYKNNWLLCNLAVADLLQGAIAVPLRIVETFPSFANYISCRVAIPLSILFGGTSNITILFISVERFLAIYYPFFHIDFFTSKVAKSLIGFSWFTVGFFSLISATHLTWNEKNPSQHMRFCRFPVYLRKEYIWSLYSYVHIIPISLVVVLYGFILKASCQQAHRIHQQNVAVCINRFSRSGKLTLNAKSSSNLSLYLKKFKGIKVVSVVVGLFIVLVLPIVVIDVIDVVQGTRPSPDVVQLAVCMIYANNCVNVFVYAGFNQEYRQNFKRILRRIFCWSRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIP2</accession>
    <name>A0A6P8HIP2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Hemicentin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116293014</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556259.1">
        <property type="nucleotide sequence ID" value="XM_031700399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293014"/>
    <dbReference type="KEGG" id="aten:116293014"/>
    <dbReference type="InParanoid" id="A0A6P8HIP2"/>
    <dbReference type="OrthoDB" id="5985519at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000003">
        <property type="entry name" value="fibrillin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000210">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006605">
        <property type="entry name" value="G2_nidogen/fibulin_G2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056475">
        <property type="entry name" value="GBD_Hemicentin/VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF27">
        <property type="entry name" value="FIBRILLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07474">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23560">
        <property type="entry name" value="GBD_Hemicentin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00682">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54511">
        <property type="entry name" value="GFP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50993">
        <property type="entry name" value="NIDOGEN_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="329"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="419"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="509"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="599"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="710"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="812"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Nidogen G2 beta-barrel" evidence="21">
        <location>
            <begin position="1018"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1254"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1384"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1465"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1508"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1590"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="792"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031556259.1"/>
        </source>
    </evidence>
    <sequence length="1794" mass="197214" checksum="3580F08867A655FD" modified="2020-12-02" version="1">MDYYKAFVFLCVNSIVLSKTGAQNGIPEGAATLAFVFDTTGSMYDDLVQVRARASKILAESLKQSVKPLYNYALVPFHDPDVGPATITTDAKLFQRHLDELYVQGGGDCPEMSITAILLALEISLPGSFIYVFTDAQAKDFDVTEKVLKLIQQKQSQVIFILTGDCHNKTIDPDFSTYKLISATSNGQVFNLKKKDVNQVLRFVEKSVRANKVNLLSIDIHEASPRTFAIPVDSTLERVTVSLSGQDANLVIRDPDGVIITQATGLQKLLSLKTAVSVAVRRPRAGIWNVTVECSGGFTLRVTGLSPVTFMYGFSLTVVDQMRNLLKLPFVVIDTSTKNFQQGEEIQCACLVKGFPEPSVVWNKDGKRLTSSSSIXITDDYVLKIKNAKPSDAGRYECVAWNSIGQSRAVVNLRHTVPPSVYINKEEILARVGDSVTLECRANGQPKPQIQWYKGRYAVLPSRRIATSSRGHLIINAVQRSDTGFYTCVALNIVGSDSITVSFSVQVPPRVTVERSEVYLPPGGSTSVQCLAVGIPPPVVNWNKNKVSLGPDGRVYANDAGELIIQNAVSGDAGTYECIARSVGGSTTVPVKVTVGGAPYISKSLKDKAVTIGENVTFHCDVQGAPIPKVSWRNTMGLVTVNKNPRYSFPSYGALKIVXVQVKDAGRYTCIAENEFGRIRASAVLILIGLSKLEAFQWSQINLRLLSVSPKIIKPPKDMTLLEGNTITLECVTKGFPVPKIQWKLNGALLPYNQSVLQIKNAMKKKHEGVYMCVAGNLAGRAEAGSRVRILSRAPPTESPTDDDTSAQASRPKFTKSPQDTVVDVGSSLLWDCAATGNPTPTXRWWRLGVELRPPFPDRITILTNNSLRIENVKTEDEGTYQCHATSNSLIHAVQAILTVRVHGAWSEWGVWKSCSHTCGTGTRFRYRTCDSPAPVNRGRQCEGTNIDRDLCNTNICPVPGQWSYWGAWSRCSVVCGVGTQVRTRQCSNPPPQYGGDDCFGSNAESRKCNARKCTIDGEQSAIGXIKGVVNNVMLPNLVLKANITRRRSNITEVSCSINGLPRPMVNWFKYAVPITAPVYWAGSGGQPGFQNGLERTQGLFNFSTRIGYPNGEYLSIDHTGRGLNEQGALVMDVSIRGRTPNFPPNSKVSFQDFKDFYIQTGSGQVSSTGERFFNVNNKRFQYICNNTVRYKPVVAGPPRSLSQTVEVMEVDVKDMPDQTALDIRMKTFVKRSPVPRECPQGLVKDAAGEFCIDMNECLFPDTCSHICENGFGTFRCLCRPGFYLLEDDKTCEDIDECSLPSTRCPAGYTCVNARGSYSCLVNCSVGYSRSGDGTCVDTNECESYVSRPISNQHPCSHVCVNSPGSYTCSCKQGFELVNGKCQDIDECVNEICPHGCLNTEGGFECSCFPGYKVQDQTNCVDIDECKLNKTLCGNMQCTNIEGSYKCLQSCRPGYKRTLDGNCIDLDECTEGGHDCLTNQLCMNTIGSFKCMCPRGYRSVDSQRRCQDLNECESFPGICQYKCVNTIGSFKCICPPGVSLNPDGQTCSGXXGCLLNNLRCAQRCVSTPAGYRCSCSKGYRLHQDRQGCMDVNECLSNQTNSCQYECINTIGSYRCRCPPGYKMSTDGKKCEDIDECSQSQSVCQQPNSRCFNTHGSYRCVQTQCPSNYNVLSPGYCLNSCNMPGFCATQALRYYTVTLPLGVPANQDLLHLIPYYPPHLSTNQYVCDFQYFFPASSSPFGIRKTGNEAIIYTIDPLTTPGLHQLHVRADIKNADGTSAYQTDFTVYIDVARYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIW8</accession>
    <name>A0A6P8HIW8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116291747</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031554813.1">
        <property type="nucleotide sequence ID" value="XM_031698953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIW8"/>
    <dbReference type="FunCoup" id="A0A6P8HIW8">
        <property type="interactions" value="3044"/>
    </dbReference>
    <dbReference type="GeneID" id="116291747"/>
    <dbReference type="KEGG" id="aten:116291747"/>
    <dbReference type="InParanoid" id="A0A6P8HIW8"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000079">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049020">
        <property type="entry name" value="PRKAA1/2_AID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031554813.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="60436" checksum="E584A66B7C401966" modified="2020-12-02" version="1">MASLKDKLGSKLSIGNYNLGATLGIGTFGKVKLAEHQLTGHKVAIKILNRNKIKTLDVVGKIRREIQNLKLFRHPHVIKLYQVISTPTDIFMVMEFVSGGELFEYILKHGKLEDKEARRFFQQIISGVDYCHRHAVVHRDLKPENLLLDSNLNVKIADFGLSNIMKDGEFLQTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHIPTLFRKIKGGVFHIPPHLNPSISSLISKMLLVDPMKRATIQNIREHEWFKNGLPPYLFPATDEHDNSIDEECLAEVSSKLHCPKSDILAAINSGDPHDQLRIAYDLILDNKKMRLLALETGHNDHFFSSVSPPTSSFHVTEATNPLAMNQNLLTTTTGRPRAGTLPTTPTKKQPYLKLAQGKRPKWHLGIRSQSKPNDIMSEVYRAMIMLGYEWKLVNPFHLRVLGKNKVSGKTTKISLQLYQVDHKSYLLDFKSLASPASNEQLASFGSGKSSRRSSANSSFSSLKDCANQPNEQMGNSSGSHHTLDFLEMCSNLIIALAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ33</accession>
    <name>A0A6P8HJ33_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor Dp-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554863.1">
        <property type="nucleotide sequence ID" value="XM_031699003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ33"/>
    <dbReference type="FunCoup" id="A0A6P8HJ33">
        <property type="interactions" value="3201"/>
    </dbReference>
    <dbReference type="GeneID" id="116291793"/>
    <dbReference type="KEGG" id="aten:116291793"/>
    <dbReference type="InParanoid" id="A0A6P8HJ33"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.80:FF:000001">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
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    <sequence length="543" mass="58797" checksum="A110210B87FEC2E2" modified="2020-12-02" version="1">MSNPGTTLTSVWIEGQPSPVKGTPSSPTKRVVGRDGHAVPEGYIKFYNSGIDSLVMGAGMIDNNGQIEHTKNSSITLSKAQATTTFPSSTSMPSGTPTKMSPLILPKTSNATPGSPMVLGSPQGQQVISVGGSPRTPATMIAAPIIPSPSNTWPRGTPGSGRKRRGEFGENDIMDSAERRKRGKRLPSAGRGPVGDKSGKGLRHFSMKVCEKVQQKGTTSYNEVADELVREFSDPEKHLSPTDQAYDQKNIRRRVYDALNVLMAMNIISKEKKEIRWIGLPTNSAQECQQLEEEKKDRQDRIRQKTAQLQELILQQIAFKNLVQRNRVNEKQQGAPAQNTTIHLPFIIVNTSKKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMNMAFGLEKKLCSEDNLNRSRTMVPKALEPYVIDMAKSGPVGLSSNSISPTSVSSNSGKSPLVAAPARMSPLPITNTPSSPLATPLPQGTSPLAMANNCKGTARSSRTSSMASDGVTSHRTVSPCSYPSSPASVSEADSESSQDGFTDTDGQNSNQ</sequence>
</entry>
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            <begin position="1"/>
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    <sequence length="84" mass="9659" checksum="A080E08CF89A5ABA" modified="2020-12-02" version="1">MAASSGGLRKALFRSPPTVETPSKNPEALESLLNKIQVDIEVDNNLNSLKREMHEQRMAKLRQELEHISQDQWKYKPIDQLIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMB4</accession>
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        <name evidence="4" type="primary">LOC116290826</name>
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    <sequence length="248" mass="28000" checksum="EBCCBA3CE129F2C4" modified="2020-12-02" version="1">MTTVGYGDKTTRTFWGRMFAVFWMXLGTIVMSMFTGQITANITSSEIATVDSMDTKVGVPTGMKTFFEQEFNLGARYFDMNYSKMEEDAMLGNSNMEFYLLHDYQVAKQWLRSSKEVKIVKSVDHQFGIGMLVTGDFDPLTSMLTCIQREVTDFYQIEMANQKLQAHNSSFPPQESGIASQHVLLIATASLLVLLVVMGFLCEWLRKGKTARVSDVESQVPRPAFSTTIPSFFLSSQELRPINSNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN37</accession>
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            <fullName evidence="13">Tyramine receptor Ser-2-like</fullName>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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        </source>
    </evidence>
    <sequence length="388" mass="43449" checksum="1B1BC0C346983F06" modified="2020-12-02" version="1">MLKNQMALDNQTLANGVLHSSTNRSLVERNNTLHGNMDDSFRVPLSLMSCGVVIGNSLVCALFCKFRKLRTITNSFVVSLAVSDSLVAVLFVPCFLLDGHVPFFALIVPYIIGYILFAYLFNFCGVTYDRYQAIVKPLSYNSRITRSAVNKILTLVWTIPMALTLIPTTWETQPTKIFTLAKRSYQGFLILVVTACSAGILVAYSKIFQETRRQVKWMVAVGVPQIPAAFAEKNSLRGDNSGIKRMNKSRKISMNIAAEVKAAKVFAVLMITFSVCWLPLIVINIIEALGFQKSVPEKLIVVSLYTLVGNSLIDPFIYSLYKTDFRRAFRRWFGCKGAQHSDHEFTSNCSNLFGRDSYRPPKPTQSPIKKGSTLPEPLNQSFSTETFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPV4</accession>
    <name>A0A6P8HPV4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Testis-expressed protein 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557631.1">
        <property type="nucleotide sequence ID" value="XM_031701771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPV4"/>
    <dbReference type="FunCoup" id="A0A6P8HPV4">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="116294217"/>
    <dbReference type="KEGG" id="aten:116294217"/>
    <dbReference type="InParanoid" id="A0A6P8HPV4"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557631.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44638" checksum="61AF60C67132EED8" modified="2020-12-02" version="1">MASSRPTSGFSGDGGRRSGSNNRPPSGKKQNVTQQLLSKEEEYMRLNAEIEQKTASLIKEAEEVMQDQDKLLTRPATITDLSGSADLEDFLSLSIGASIPMSKPGSTTPNQSRPVSKNKKRPKSKTGVDNRPKSGAPRSKSAQKPSANNVVVDDILAERINLATKISSLEDEAKDESFITTTSYADDGILPTGAEDMGSEATIRFLKAKLHVMQEEMDRLSSECSNKDDQLGSLQGQVKELTEEQSRLQKTNTSLQSQIEKHKKLYAESKSKNDSLEQLLSSTKKELDSIQREQKQFVSNKNATEVRLNRALEEIDKYKTALHKAKTSSKDSSDQDRRRLDQILAESKRLEKQKNELMTGFKKQMKLIDILKRQKMHIEAAKLLQFSEEEFVKALDWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ00</accession>
    <name>A0A6P8HQ00_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-related protein Rab-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Small GTP-binding protein rab1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Protein transport. Probably involved in vesicular traffic from ER to Golgi.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554712.1">
        <property type="nucleotide sequence ID" value="XM_031698852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ00"/>
    <dbReference type="GeneID" id="116291628"/>
    <dbReference type="KEGG" id="aten:116291628"/>
    <dbReference type="InParanoid" id="A0A6P8HQ00"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001018">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554712.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24324" checksum="0ACE8A95449FE2A5" modified="2020-12-02" version="1">MEDDSRINLEVQYDYLFKILLIGDSGVGKSCLLLRFVDDSHRESYLSTIGVDFKIKTIELDGKIIKLQIWDTAGQERFRTITSSYYRGAHGVMIVYDITKRESYNHLHKWLIEIETYASEGVLSILVGNKIDLESDREVSTETGQEWATTHDMPFIETSARDSKNVKDAFHLLARLLNKHIVENDTGRRGLVVGENGTILPGHNVENNSKCSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSZ6</accession>
    <name>A0A6P8HSZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558556.1">
        <property type="nucleotide sequence ID" value="XM_031702696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294996"/>
    <dbReference type="KEGG" id="aten:116294996"/>
    <dbReference type="InParanoid" id="A0A6P8HSZ6"/>
    <dbReference type="OrthoDB" id="5962108at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558556.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22461" checksum="908247D4F6253C44" modified="2020-12-02" version="1">MDVMNEQDNKIIQKNYVRLLETXEXXNLLGYLYQEGALSDHDKEKIYALGTSKEKAETLLVIIMKRKDGLKMLIKALLLSRVQGFLGNELLEIVTWGEREMETFKLELQGKIDHQQMLEANVAALKQENNQLKEKNANLTERLQEKDETIIALRQQLQEKNRRDVPKQPKLSRSPAFLHTCNGKHRRSQSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU06</accession>
    <name>A0A6P8HU06_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Substance-K receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556107.1">
        <property type="nucleotide sequence ID" value="XM_031700247.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292898"/>
    <dbReference type="KEGG" id="aten:116292898"/>
    <dbReference type="InParanoid" id="A0A6P8HU06"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556107.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33655" checksum="3BEF6021984D5F3A" modified="2020-12-02" version="1">MAVSDLIFALFSVPRRVVNILYSNIWLIEGNFGLALCKLASXLQDVSLAVSIYSCVFXALDRFYAVVHPLRGGLSRRKVKYIIPGIWMFSMAMFSNYFFSVTXVKKLNWKICIHDFTRIGITTILQLRILYFVIFALNVGIPLPIISILYLRIVLKLRRAAVPGQAGNTSSVRERQNKNALKMSAVIVSLFFLSFLPFSVTALLINFGNLDNLTPAVLNDLSFSTILIAESSTCYNFFIYLVFTQVYRQNFKNLFSKCTCVHRFSGRFRTNSFALQNNVAGIERQGEVNLNAIKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVL8</accession>
    <name>A0A6P8HVL8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560454.1">
        <property type="nucleotide sequence ID" value="XM_031704594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVL8"/>
    <dbReference type="GeneID" id="116296558"/>
    <dbReference type="KEGG" id="aten:116296558"/>
    <dbReference type="InParanoid" id="A0A6P8HVL8"/>
    <dbReference type="OrthoDB" id="10318318at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560454.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26077" checksum="F769A314BD724D93" modified="2020-12-02" version="1">MVLISIDRCIAIRKPHLYRSTFTLIRVVIFLAVVWIFGIFFSVTATFLLSVHPSVYLLLIMYGVTATLVAFFQLGVYTGVKKQSRRTADIRSSVHRQLTFERTATTVVLYVIIALAVCHVPLLSMYIMISTGKNYMLLGKAWMELLLYLNALANPLIWLKTNRKVRKAVVESLTAFRLYFVNSTPVHSLNSNGAPSDRATNDTATELKSTYMRKETIHRDTVNPSNIKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVR4</accession>
    <name>A0A6P8HVR4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116295702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031559466.1">
        <property type="nucleotide sequence ID" value="XM_031703606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVR4"/>
    <dbReference type="GeneID" id="116295702"/>
    <dbReference type="KEGG" id="aten:116295702"/>
    <dbReference type="InParanoid" id="A0A6P8HVR4"/>
    <dbReference type="OrthoDB" id="5982605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="5"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031559466.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="63102" checksum="F209514018431786" modified="2020-12-02" version="1">MEIPVFFHNLREYDSHLLLQGVEGHEVKCIPNNKERYMSVTIGKLKFLDSQQFMADSLANLAKYNEDSPISDEYDAERKGVYPYEYMDSWERFEEQQLPPQEAFYSTLNEAGISDDEYAYAQEVWEKRACRNLGDYHDVYLLSDVVLLADVFQSFRKMSMSYYGLDPANFYTAPGLSWSALLKKTDAQLDLLTDYEMYRFMEDGIRGGVCGPSHRYARANNPQVEGYDPEKPNTYISYLDANNLYGWAMSQHLPVRDFEWATPREPEYYMRIRPDSRKGFILEVDLEYPPELHPLYDDYPLAPEAIEIPFEQLSPLQKKLCPNYKPYRKLTLNLMPKKKYVVHYRNLQFYVRHGMRVTKVHRALKFRQEPWMQPYIDFNTQKRTAAKNDFEKNLFKLMNNSVFGKTMENIRKRVSIRIANTREEAERYVSQPGFVRYVDMLNFFVIHMKKANLFLNKPVYTGFTVLELSKLLMYEFYYDKLKPKYGDRCHLHYTDTDSLIMDRNPRHLRGLPRRSRRIRHLGLPPRPSPLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVX8</accession>
    <name>A0A6P8HVX8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293462</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556747.1">
        <property type="nucleotide sequence ID" value="XM_031700887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVX8"/>
    <dbReference type="GeneID" id="116293462"/>
    <dbReference type="KEGG" id="aten:116293462"/>
    <dbReference type="InParanoid" id="A0A6P8HVX8"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031556747.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12158" checksum="6FE68264D27E9BCC" modified="2020-12-02" version="1">METYEECCCEMLAVDKDDDAILSQLVDSFENENSSLTVKTIEEEEVEEPQQSRFKKMQERNLVELAEDRFQLIRRVKPCGLSAYTKIGQCGERGVTFLKMRSLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX60</accession>
    <name>A0A6P8HX60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein kinase receptor Tie-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559911.1">
        <property type="nucleotide sequence ID" value="XM_031704051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX60"/>
    <dbReference type="GeneID" id="116296089"/>
    <dbReference type="KEGG" id="aten:116296089"/>
    <dbReference type="InParanoid" id="A0A6P8HX60"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559911.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13380" checksum="5B568E27B5AC5FF0" modified="2020-12-02" version="1">MYGWEWMDGNGWMELRSFSIMFIYPGGRPYAGMNGLEVVEMIKNGKRLSKPPHVYSKLYSLMLQCWSKNPNHRPDFTSLCKQITLLAKDHQRYLNLKEYDHRLYVNVSSLEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXC5</accession>
    <name>A0A6P8HXC5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of G-protein signaling 20-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560053.1">
        <property type="nucleotide sequence ID" value="XM_031704193.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HXC5">
        <property type="interactions" value="1801"/>
    </dbReference>
    <dbReference type="GeneID" id="116296204"/>
    <dbReference type="KEGG" id="aten:116296204"/>
    <dbReference type="InParanoid" id="A0A6P8HXC5"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="145"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560053.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="31272" checksum="70AF2092A7CDEE8F" modified="2020-12-02" version="1">MFEVAFVIKXFTQIHPIRLWLFFELMSTSILNLTKKNVEHRQGDQAQVRRDTSWYYNFSEPIEDTKADTRINILEIYINGKENNPLERCGDHSPLFTRRRDRCCFCCFCCAFECPGSRGRVGNMEQASRYNPRPSTEEVQEWAKSFEKLLSSKSGIKLFHDFLKSEYAEENLLFWLAVEKLKKETEPGNIKNLAQMIYNDYVSTESPKEVSIDHKTRQVIDNEIAHQPTQFTFDKAQQHVYYVMFQDCYPRFLVSAAMKDLLNGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXU7</accession>
    <name>A0A6P8HXU7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC116294038</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116294038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557422.1">
        <property type="nucleotide sequence ID" value="XM_031701562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXU7"/>
    <dbReference type="GeneID" id="116294038"/>
    <dbReference type="KEGG" id="aten:116294038"/>
    <dbReference type="InParanoid" id="A0A6P8HXU7"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="28"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="518"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031557422.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="68533" checksum="0A9A3E0CA45D74A2" modified="2020-12-02" version="1">MGKHGIENWSDCLIAVLVILLFCVTLLLNILALHYTYSKIRKPSNKKIPHLLVGALSLGGLGIAIFEYPPFIASRFQGEWLNDSGVCSFVAFIIVLFGNFTICLVVLMSLERLGAIVFPFYYKEHVDFRKAVIVLVLVIIYSILLASLPIFLDRIRLNVSTGVCTYAVDTHNTNTRIIVAVMVSHYIASIVLMFISNLVVVRTVSKLDKNTMSDEYSSRSGERKHHGGNACLNFAKMVGVLAFCYTVCWTVILMRILLLYVYGWSNYYYDQVVIVLTTFDPLINHCVCLWIMRKYRDGYASSMGSLVSCFKISDDGIWATTITRLSSMSRRSTYSRASTRSSSRQPSKPYVYKQVPQNIEANRPPDLLPDIEDQQKQFPVLNPEKEDKTSEKRVLDKRIYSDTNKEWSELIKELNAEKNEKSPRVSSEFQRSKIEAIMEVPQEGVSKHYKTKSKWLEIIQKHKAKNQGDLEKGKVDILEERSAGFDVTAGGSLQVGAQQYALKKKDNLPELLQEIKRETKSARPELLGCVEPGTSRDNDINPIPELLQDIKSNDEETTKTQNRRSSGDKESEQKDASSSEPKAEEDEQGPDAQKENQDKEENSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYM4</accession>
    <name>A0A6P8HYM4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cyclin-dependent kinase 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116297398</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561479.1">
        <property type="nucleotide sequence ID" value="XM_031705619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYM4"/>
    <dbReference type="FunCoup" id="A0A6P8HYM4">
        <property type="interactions" value="3637"/>
    </dbReference>
    <dbReference type="GeneID" id="116297398"/>
    <dbReference type="KEGG" id="aten:116297398"/>
    <dbReference type="InParanoid" id="A0A6P8HYM4"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000088">
        <property type="entry name" value="cyclin-dependent kinase 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000122">
        <property type="entry name" value="cyclin-dependent kinase 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031561479.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53995" checksum="EE569ACA386219AD" modified="2020-12-02" version="1">MDYEFKLKLNELRERVEDIFEFDGCKVGRGTYGHVYKAKHKDSGSGNGREYALKQIEGTGISMSACREIALLRELKHPNVISLQRVFLSHADRKVWLLFDFAEHDLWHIIKFHRASKAQKKTVPVPKSMFKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGNERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTCEPIFHCRQEDIKTSNPYHHDQLDRIFGVMGYPQEKDWEDIKKMPEHSTLLKDFRKSNYASASLWKYMEKHKVKQDSKAFQLLSRLLVMDPNKRITSEQALQDPYFKEDPLPTQDCFVGSPIPYPKREFLNDDDNDSKSNASKNNQGKQDNSDTNGQPNSKRMRGLSVHQPDQFQKQQQQKQQQQQQQQQQQQQQQQQSYAFQNQTNQPQQLQFMFGNNGGNAQSYSNQQGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYW4</accession>
    <name>A0A6P8HYW4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LOW QUALITY PROTEIN: cleft lip and palate transmembrane protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116294392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557850.1">
        <property type="nucleotide sequence ID" value="XM_031701990.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HYW4">
        <property type="interactions" value="1764"/>
    </dbReference>
    <dbReference type="GeneID" id="116294392"/>
    <dbReference type="KEGG" id="aten:116294392"/>
    <dbReference type="InParanoid" id="A0A6P8HYW4"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557850.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="73124" checksum="F0ABA4CE06467F14" modified="2020-12-02" version="1">MADTARESGSNEVENSQSTQPPAENNPQNEQPQQQESPWKGILFRIFIFWLISNLFRGKQQQGTENSGFTPATNLFKPRDFMDLYVYISDKSYMQPEDFNNTSLLIWKQNKLQFGNWTCGENGDGSYTYSYTIKASEELMNNGSLYIHVFVTKMNRPPNPKAPRYRRLDVVNRTMLLTVYKKRRISNTVNLLTGLQTDGKKKEESIKSEDKKKVDIISYWHPNLTINMMDDQTPWTPGAVPPPMDEFIQFDNLTNMYFPLLYLNNYWNLGSEYMPINETTPELELHLTYSPISLFKWQMYESQRVRKKWFSMLGDEGEQSEEEQDTLKRTMVETNPYLLGITIVVSLVHTVFEFLAFKNDIQFWRSRKSLEGLSVRSVFFNVFQSIIVLLYVLDNDTNTMIIISCCIGLVIELWKINKVTDVKFDRENRILGIFPRPKFEDKETYVQSSTRQFDEMAFKYLSWALFPLLLGYAVYSLLYLEHKGWYSWVLGMLYGFLLTFGFIMMTPQLFINYKMKSVAHLPWRMMTYKALNTFIDDLFAFVIKMPMMYRIGCFRDDIVFFIYLYQRWIYKIDPKRVNEFGVSGEDLANGTAIENKDDQKDEQKEAKNGTVSPPSDKKNDXIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ12</accession>
    <name>A0A6P8HZ12_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116296627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560531.1">
        <property type="nucleotide sequence ID" value="XM_031704671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ12"/>
    <dbReference type="FunCoup" id="A0A6P8HZ12">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="GeneID" id="116296627"/>
    <dbReference type="KEGG" id="aten:116296627"/>
    <dbReference type="InParanoid" id="A0A6P8HZ12"/>
    <dbReference type="OrthoDB" id="414267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047349">
        <property type="term" value="F:D-ribitol-5-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000003">
        <property type="entry name" value="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43015">
        <property type="entry name" value="D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43015:SF1">
        <property type="entry name" value="D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031560531.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47852" checksum="0E4C6B3A0BD189AA" modified="2020-12-02" version="1">MEDEESDEKDKVTFTVCAVLPAAGSGTRMRMETPKQFCEILDRPLISYTIEAFERVRWMKEIVVPVAEDTLEHMQQILKNFNHTKVRLTLGGNTRHKSIFSGVKELANHKKPPDIVIIHDAVRPFVSEDILRKVALAANNHGAAGVTRPLVSTVIACNEEGFLDHSLERSTYRNSEMPQAFKFDVIFGAYQKCTEYDFEHGTECLHLALTYSNTRAKLVEGTDSLWKVTHKRDLFAAEATLKELRRLKALVISDQQGPVEEQLISKLRKQNVDVQFSSSSDLSNIPKAALCSVDVVCKIIRHTCLSRVSGTAEEERPSLILDLSPSIEALEVFDNSAHQRKSILTLVISHEQNGLDDLKKHMVELNSRARSKGITCFGIYVDTAKCNKEDHWPIEDCKNLAEMTSEIALNTSSLLSGQVFEYLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZF2</accession>
    <name>A0A6P8HZF2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116294565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 6"/>
    <dbReference type="RefSeq" id="XP_031558050.1">
        <property type="nucleotide sequence ID" value="XM_031702190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZF2"/>
    <dbReference type="GlyCosmos" id="A0A6P8HZF2">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="116294565"/>
    <dbReference type="KEGG" id="aten:116294565"/>
    <dbReference type="InParanoid" id="A0A6P8HZF2"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027909747" description="Tartrate-resistant acid phosphatase type 5" evidence="10">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="33"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="9">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031558050.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41585" checksum="012B7BB59BB61036" modified="2020-12-02" version="1">MDSFIPLLLVVLISLAYCCVGQRKDSEEDGKLSFLAVGDAGGFNYAPYYTKNLENVAKQMGKTAKKTHAKFVIGLGDNFYWKGVKDVHDFRFNATFENIFRAPSLHRTKWYMLAGNHDYLGNVSAQIAYTKVSRRWHFPDFYYTTVHRIGGTCKTVQIVTIDTTLLCYKGGGIYPGKREQYRWLNEILRNSEADYLVVAGHHPVYSIGMHGSNVCLNDKLRPLLEKYDVTAYLSGHDHNMQHFKPLYSNVHYLVSGSASNHNQLQYNKHKVPLNSLRFFNGKTGGFTLLQATPRHLTVSFIGSHGKILHTEKIPPRKTRPCSKKNTKAPFIIEDFEDSVLGAFFGLQEDNELRQHQRERHTGMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I055</accession>
    <name>A0A6P8I055_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558237.1">
        <property type="nucleotide sequence ID" value="XM_031702377.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I055">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="GeneID" id="116294726"/>
    <dbReference type="KEGG" id="aten:116294726"/>
    <dbReference type="InParanoid" id="A0A6P8I055"/>
    <dbReference type="OrthoDB" id="5951220at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF11">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="189"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558237.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="65109" checksum="673205FE5CD12CAC" modified="2020-12-02" version="1">MPPRIEKWVMQMQDVDYELIYEPGKDEADPLDYLSRHPLPETEDDGTEKIIKWTVEAEHSVVLERIREETLKDKTLQKLSQRIAKGDWEKFRKDRDIEPYTHIKQELSTAEGLIFREERIVLPENLQRKAVKIGHSLGHLGKTKTKRMLREKYWFPYMNHMIDNAIDQCYECQVATKDKQTEPIKASSIPDKPWDTVSLDHGGPYPDGHYXLVIIDKRTRYPVVERVSSTSXTTNKERLKHVFATYGTPRRIESDNGPPFNSRDFEDFARKEGFQHHKVTPLHPKANGEAERFMQMLNKTEKIEHLQGKDKLESQNAIHDMLTAYRSTPHPATAVSPXEXMRGVAVRTKLDYIAPNKQTSEEDEQINKNDARYKEKMKVQRENNRTKEKRLLLGDYVLVKQENKNKWSTPYEPIFYTICDIQGSKITARRTTDGRTVCGDASYFKLVNTVINTADEAETVGPSQEEPKATTDTKQEDPRERILRETKSHEDRKKPPNNEEKQAELKEKSSKMTQVKQEKTEERVESEKPQDEGEKSNRPRRERRRPKTFEDYYMYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I089</accession>
    <name>A0A6P8I089_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296957</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560941.1">
        <property type="nucleotide sequence ID" value="XM_031705081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I089"/>
    <dbReference type="GeneID" id="116296957"/>
    <dbReference type="KEGG" id="aten:116296957"/>
    <dbReference type="InParanoid" id="A0A6P8I089"/>
    <dbReference type="OrthoDB" id="5946236at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053269">
        <property type="entry name" value="Asp-Met_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37018:SF1">
        <property type="entry name" value="CULTURE SPECIFIC PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="113"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560941.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44373" checksum="9D6761964EB47DDA" modified="2020-12-02" version="1">MSGNIKQPLLTLGSLIKKDLQDAYFLPAWPSSYSLQNKFYNNLKYCVFDNAPSSKIYTDFIFPCRNLPATGNEVPVLSDYQPPSFLKEHWKKWLPDFPDADIRPVSQGLRDDKPIVTNAAIQSLPKSKHCVDPDVLYRVQLKSSIHDIGVPCPKYFPSEDAISFPCMVKVDMSWSGYGNRVAYNGNEFAAIIKEIRDNGWTGNIIYQQFMEDVNEMVSFEFYLHVSGKMHWLGTNVGGFEGFKWTNGVVEWNKQEEYKNRFYDQFVVPVKDYLHKQGYFGVVMCEIMLCDYGMYLVDLNPRVSGDTHHLLLADYMMQFGFPDSIMKQGMKTNKSAKTLVEKANHINTGTSAGRVVIIAAADVEEDQCEYEISVFAQSRKEALELYNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0E0</accession>
    <name>A0A6P8I0E0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297011</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560996.1">
        <property type="nucleotide sequence ID" value="XM_031705136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0E0"/>
    <dbReference type="GeneID" id="116297011"/>
    <dbReference type="KEGG" id="aten:116297011"/>
    <dbReference type="InParanoid" id="A0A6P8I0E0"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560996.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42610" checksum="BACE84A3694C1EFE" modified="2020-12-02" version="1">MNTPVLPPLSPLPSSPTQNYDADMLQLLGSPFNLPDDMASVLSSDTPLSTGSDLVRAMDPPSPEPSPGPSPDRTPGASPTFSPSASPAASPPSEVANLAAWTPSSGGRLTSLPDATLDQMNKEELREYAEALKSLAEKYPQVKETLTPTIKNVMTRVDGRWRGNRSEKRMNLAEVEEYVKELEATDQSKFDETSQMRIRYALEKALARRLQLRKEAEQDRRRDGGDDQEDRGWDDPGGDDGDDDGGGDDDDDDANDDHGERFKNADQDTVSKALRKKLGKGDHQTIANTTTVTTVRRGKRPVVEREHNSQTFPGPGSDNDDDDDDDGGDDATIEGGVLRRKRKSRVSKSKPRRKKHSQQGGYNKTPHEVVDQYIRFLRDAKRKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1B0</accession>
    <name>A0A6P8I1B0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">Protein kinase C</fullName>
            <ecNumber evidence="2 16">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC116297255</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="20">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 16">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 16"/>
    <dbReference type="RefSeq" id="XP_031561306.1">
        <property type="nucleotide sequence ID" value="XM_031705446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1B0"/>
    <dbReference type="FunCoup" id="A0A6P8I1B0">
        <property type="interactions" value="2259"/>
    </dbReference>
    <dbReference type="GeneID" id="116297255"/>
    <dbReference type="KEGG" id="aten:116297255"/>
    <dbReference type="InParanoid" id="A0A6P8I1B0"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20833">
        <property type="entry name" value="C1_cPKC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05587">
        <property type="entry name" value="STKc_cPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000012">
        <property type="entry name" value="Kinase C alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000023">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000006">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000052">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014375">
        <property type="entry name" value="Protein_kinase_C_a/b/g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000550">
        <property type="entry name" value="PKC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="22">
        <location>
            <begin position="147"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="337"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="25">
        <location>
            <begin position="596"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="343"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_031561306.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="77170" checksum="F9D874B80DC86645" modified="2020-12-02" version="1">MAEQKPKGFNRRGAFKQKNVFNVKDHQFIPKFFRQPTFCAHCKDFIWGLLGTQGYQCKVCSFVVHKRCHEFVSFKCPGAEDLNENVPVSPHHFKVHTYSSPTFCDHCGSLLYGLIHQGKKCEACEMNVHKKCEQAVPKLCGADHTERRGRIHLKVCYEPTKSSNGEERGLLRVEVREAKNLIPMDVNGFSDPYVKVKLLPDPESSSKKKTKTIKKTLNPVYNESFDFKIQPKDKDRRLSVEVWDWDRTSRNDFMGSLSFGVSELLKQGVEGWFKLLSQEEGEYYNIPINEDVGQAVSELQRKFKYLKTQLEEEEQRYQAKKDLVADPNAKKFRPEDFHFLKVLGKGSFGKVMLAERKNTDEVYAIKVLKKDIIVQDDDIECTMTEKRVLALLGKPPFLTSLFCCFQSMDRLYFVMEFVNGGDLMFHIQQAGRFKEPQAVFYAAEIVIGLLFLHKRGIVYRDLKLDNVMLDSDGHIKIADFGMCKESMGDGKTTRTFCGTPDYIAPEIVAYQPYGYSVDWWALGVLIYEMLAGQPPFDGDDEDELFNSILEHNVSYPKSMSKESVSIIKGFLTKHPAKRLGCSDNGEFEIRDHLFFRHIDWVKLASREVQPPFKPKIKSKRSFDNFDPEFTDEAARLTPCDKSFIANINPKDFEGFSYVNPDFETTEGEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2M8</accession>
    <name>A0A6P8I2M8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipase DDHD1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559157.1">
        <property type="nucleotide sequence ID" value="XM_031703297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2M8"/>
    <dbReference type="FunCoup" id="A0A6P8I2M8">
        <property type="interactions" value="1245"/>
    </dbReference>
    <dbReference type="GeneID" id="116295478"/>
    <dbReference type="KEGG" id="aten:116295478"/>
    <dbReference type="InParanoid" id="A0A6P8I2M8"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF48">
        <property type="entry name" value="INTRACELLULAR PHOSPHOLIPASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="3">
        <location>
            <begin position="505"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559157.1"/>
        </source>
    </evidence>
    <sequence length="782" mass="88932" checksum="8C87EEEC9B322757" modified="2020-12-02" version="1">MEDNADEPSETSQESSPSSPPARPSRPPRPPPPDIKRNPSIAQHLDALQKLRPERIRWFFKEEDNKRWTPFNGRDSLSIEETFRKIKELETSSPKADPDKPLNTTMLYDFPIVKGGLYEVDVVARQCSPIYWKEKGMAVCRGTWFIGTPGSPNLWQPVSEEDADQIENSHQSLWRAMGLHVGPTQDEPDKSKLGDALGRLNLKGYYVEWKEINDVWLYWDDIKSRIIRGVGTKIGLSSGVSASPLHRGYHTDAIVKDGPCDITHLVFVIHGIGQLLHMSNIVRNAKDLRTSVSKVLEKKIPGFPEDQRIEFLPVEWRSSLKLDEGTIESITPKTVTGIRNVLNTSMMDIMYYTSPFYRYEIINGVRDEMNRIYDAFCSRNPSFIENRCKVSIIAHSLGSVITYDILSLWDVELRHASEDELGRTGFLTESFTFLRNLAGTSEEESNNFNEDAKKKAKLTKPKENIRVELSKARNTVMELEAMLKTELEFEKAIETATGEFCPYALKFKVENLFCIGSPLPVFLTLRGIRPQDDVEDHVFPKAVCKKMFNIYHPADPVAYRLEPLISEDYTSIPPIQLHRFDHAKSGYAEEKKIPSEKSGWSLFNYRVGYNKHKENKEEDMSRSNSISDDSESQEDELVIVDHAAAIEQEKQEKPEKQEKQEQMKAAASKEKGVNEKKSGWMSSWFGSPRKTAKSTEDVHEAARTEADGAAAPDDSPKKIKGEHVVVPGRVLNDRLDYVLREGYMENNYISAVTSHIAYWGSCDVARFVLEKTLILSTSEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3S6</accession>
    <name>A0A6P8I3S6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116298269</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116298269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562518.1">
        <property type="nucleotide sequence ID" value="XM_031706658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298269"/>
    <dbReference type="KEGG" id="aten:116298269"/>
    <dbReference type="InParanoid" id="A0A6P8I3S6"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="38"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562518.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49747" checksum="0D4DE0F76185AA0B" modified="2020-12-02" version="1">MFKNVIRKDLQSYRPASNLLLNEKITQMLSEGRRVYHFAFGQSPFPVMAEARAALERHSGENSYLPVAGIRPLRESICNFHKEFDKLDNLNPDNVIVGPGSKELLFLVENVFQGDXFVLYPTWITYSPQCLLSHHQPVLIRTKFEDSWRVTPNGLEKVLNESKSENRLLVLCNPDNPTGTSYSAEHLKALTEVFRKYKVVVVSDEIYGRLNYTEDHECLAKYYPEGTIVSTGLSKWASAGGWRLGYHIYPETLRDLYIAVQSAASHTYSTASAPVQYAAVSYLNLSKESVTYMRNTRRTMSAVAEYCYKELIQVGVKVVKPKGGFYMYPDFEIIRLSLRKRGIETCQQMCDAMFKEALIVLMPWDTTDHEGNERLTVRLCFVNFNGEKALKACYDVMEGGGVDLGDSFVMKHCKETVDGMTMLCNWVKEQMKTKSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5Y8</accession>
    <name>A0A6P8I5Y8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116299486</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564003.1">
        <property type="nucleotide sequence ID" value="XM_031708143.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564004.1">
        <property type="nucleotide sequence ID" value="XM_031708144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5Y8"/>
    <dbReference type="GeneID" id="116299486"/>
    <dbReference type="KEGG" id="aten:116299486"/>
    <dbReference type="OrthoDB" id="6020396at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031564004.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="58448" checksum="95364F1693D81D5A" modified="2020-12-02" version="1">MVDGPKAKIFNDSIHGYIEMHPLCVAIIDTEQFQRLRCIKQMGGTYFVYPGASHNRFEHSIGTSYLAGYFVESLRRKQGKELDIEEKDVLCVKIAGLCHDLGHGPFSHMFDNDFIPKVRPLLEWSHEVASEKMFDHLIESNGGVKKMFEKNELGDKDICFIKKLMTGETPKSEEEWKEVGREKNKPRFLFEIVANKINGIDVDKWDYFARDCKYLGIKSSFEHMRCLSLARVIKSGKKGEAEICYRDIAAGNIYDLFHTRLSIHKKACQHKTVNAIEMMITEALVKADPHFKIKGENGREPSTISTAIDDMVAYTKLTDHVYYEILYSTKDELKEAREILQNIEQRKLYKFIGYTIPKDNPDEKGVPAMRKEIFDIVKENAEELKEDDIVVQLTPFKYGGTDDKDPVGKVRFYAKHRENESFNIKKEQVSRMLPVVFIEEEIRVYCKERKQPTVEKMKTAFLEWCTHRGYEVENKLQGPRIQRTDHNPNEVEHDDDKDLHLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I714</accession>
    <name>A0A6P8I714_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116296865</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116296865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560832.1">
        <property type="nucleotide sequence ID" value="XM_031704972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I714"/>
    <dbReference type="GeneID" id="116296865"/>
    <dbReference type="KEGG" id="aten:116296865"/>
    <dbReference type="InParanoid" id="A0A6P8I714"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF204">
        <property type="entry name" value="SPADETAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="13"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="811"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031560832.1"/>
        </source>
    </evidence>
    <sequence length="1138" mass="128382" checksum="9F6D5D4104205485" modified="2020-12-02" version="1">METNTPESIEVKLENKDLWAKFNTLGTEMVITKAGRRMFPFLEVSIKGLHPDETYMVILDITLVDDRRYKYNERENHWQIVDSRLLSPTPVGMFVHPVCPCSGKEVCAQPMSFNKVKLTNNYHKVPFGGHILLESMGRYVPRLSIVTYHDYYNQSWEKGVAFMFRETEFITVTAYMNKEITKLKIDNNPFARGFRENGLKWKVLHDSIYGSDVNSIDYENDQMADESRETEAPLAMTYLSNEEDNDDGIQVFHVNPSSIIVTDVLPSLPSTSCLITSTNFPSSSSKISTNSEEVNVVFEPVHNASTDTRGRVGQTSSYEAEKTGLDSLLYSRSPLQSITVDKSQFITSENSGGKSNSSDVWVQGIVGDDAEEDILCKVSDVRSIKEAPLPSDKQENTTRMLSSLECEENVECFSDKNEEGYSKDKCERIASETTTNSLKNEENCLAEEGKLAQANKDSKCVDNNETFVGKNENYFDQMRNGDGWDDNSPSDNSSELTRKTIDIQDVNKDKAISLTEGKLVHENTVKETQLNDFISACDERIAIGNEECNSMEDDVEERNSRDAVDARPSEKVQEQQNKKVMSSNAKEYNSSQGNVDIDNVKEFTLNGEYRTENTSKPQISKLLNFVNSVSMPVLKFGAEKETLSSNKDTSDSLLKKSPEKLAYLGKKRPVDDRPGLVVKKGRLMNQLNEGVKSLDQSSNVFSSINQSKDSLKSLDQSDKRLRSVSHSNVILKSMGQSKESLESLNQSDKRLKSMNHSSDILKSVDQSERNLKSVHRLSGEVTKPTKLPNNSGHHQNKKLHSSISSLTPLRDNTKKEFCNERSPRFESKIFQEQRANHETSKERPEDKISMGIRTTVINVGHEELAKPLVANGLHPRNSLYRTKYIEKFEARKERGSALQRLSQVNSTRNEDPSCMEKDGGMRHVVGNQNEVLVESVSMKSLPVILSSYSIHPSNFSNQKIIDLNNETRVDENRVPKVYPAESFLLKENTGKDVHEKCPIKTDPRCQPILGEEKRDACVHPGKSKSFYRKIIPKPMSLGSQHSLSKQQEFIDLNSQATFYQRQADNPYQSYYANKGVPLQVLYTFETRMSLSRAPDPRLPEVYNPTRTTFTGYASNLICSTLPIATNMGFSPAAPGKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7D8</accession>
    <name>A0A6P8I7D8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cullin-associated NEDD8-dissociated protein 1-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Cullin-associated NEDD8-dissociated protein 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116298808</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563225.1">
        <property type="nucleotide sequence ID" value="XM_031707365.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563226.1">
        <property type="nucleotide sequence ID" value="XM_031707366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7D8"/>
    <dbReference type="GeneID" id="116298808"/>
    <dbReference type="KEGG" id="aten:116298808"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000047">
        <property type="entry name" value="Cullin-associated NEDD8-dissociated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031563226.1"/>
        </source>
    </evidence>
    <sequence length="1231" mass="136191" checksum="2BED0672821E49DA" modified="2020-12-02" version="1">MTTSPYHIASLLDKMTSSDKDFRFMATNDLMAELQKDSIKLDDESERKVVQMLLKLLEDKNGEVQNLAVKCLGPLVGKVKEYHVETIVDTLCSNMLSDNEQLRDISSIGLKTVIGELPPASSSLAANICRRITGRLTNAIAKSTDVSVQLEALDILGDLLSRFGGLLVSYHPSIQASLLPQLKSARLAVRKRAIIALGHLVLSANSSLFVELMDHLLNELQLNTAHSTTRTFIQCIGAICRQAGHKVGEHLERIIPFIVKYSQVPDDDELKEYCIQAFESFVQRCPKEVTPFIPKIIELCLKFICYDPNYNYGDDADENMETDQEEEEEDDDDDEYSDDDDMSWKVRRAAAKCLTAIVGSRHELLSDLYKTIAPALIARFKEREENVKADIFTAYITLLRQTRPVAGQVVDADSMDEDSGPLMMLQNQIGNVVKALHKQLKEKSVKTRQGCFHVMSELVAVLPGALSEHISAIVPGIQFSLTDKSSTSNMKIDTLAFLGCILSQHPPHVFHPHILVLVPPVVQAIGDPFYKITSEALLVTQQLVKVIRPLDVKSSFDYSPYVKDIYNSTLMRLKAADIDQEVKERAISCMGQILHSLGDELEPELPTCLPIFLDRLRNEITRLTTVKAYTLIAGSPLKVNLSSILNESMPILASFLRKNQRALKLSTLNTLNVLMNNYGTSLVPDNIAGVLAEVPPLINESDLHISQLTLSLLTSTAKVHTDSMAKASATTLPAVMELVKSPLLQGGALNAMLTLLTGLVNSGIKGMAFSNLFEMLVLPIYAPQGSQHLHKQAYYSIAKCVAALTISCPNDGELVVNTFVKDIQSSKVLDAVRLFSLLSLGEIGKHVDLSSHKDLAAAILNCFSSPSEEIKSAASFALGKITAGNLTLYLPFLLKEIEQSPKKQYLLLHSLKEVISCEACTSAGIQALRPFIESIWALLFSHCESTEEGTRNVVAECLGKLTLVDPVTLLPQLQKYLDSGSAFARSTVVTAVKFTISDQPQPIDVQLKACIGQFLRTVQDADLNVRRVALVAFNSAAHNKPSLIRDLLDSILPQLYNETKIRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDTCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLASLCPTAVLQRVDILVEPLRQTLQTKVKANSVKQEFEKQDELKRSALRAVVALLSIQDSDKSPLLNDFLAQIKSSPELSAMFDAIQKDSGSSEAMDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7P0</accession>
    <name>A0A6P8I7P0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AT-rich interactive domain-containing protein 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116299997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mastermind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564594.1">
        <property type="nucleotide sequence ID" value="XM_031708734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299997"/>
    <dbReference type="KEGG" id="aten:116299997"/>
    <dbReference type="InParanoid" id="A0A6P8I7P0"/>
    <dbReference type="OrthoDB" id="5982619at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046370">
        <property type="entry name" value="MAML_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019082">
        <property type="entry name" value="Mastermind-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09596">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01275">
        <property type="entry name" value="MamL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurogenic mastermind-like N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564594.1"/>
        </source>
    </evidence>
    <sequence length="802" mass="89023" checksum="EC2429CBB408468C" modified="2020-12-02" version="1">MEERNMTPKHQAVVDKLRERLVXYRKRHSDCQSKQERSLAVLEDQERQEAMMLLNKRPLEGRNTKLFNAKMKQQDSMPKMEHPSNGLELKSTNAILQQRIISKRKHDQGMNNIHLSCDNENGQIGGESLSKYPRADDVHNSSLVSHEHQISLPSSQAEQQQQSANQGDSLSSETMXSGSVMGSNGHFVGDTSRSSPLLTSSGAHPSETYQNANRVASPNSLPPTEFKQESHSIAVSCDGGRTVRSRSRDSIPNGLGRTSTENKSTDPSVGHELQQQLDDFQRILNDMFKNAGIPSINSEISPQHHQISRPAQSQIDARDTLNVQQQNPTVPNQATGQKNKYPTPPSQGPPGALHLQHLARQAQSQRAQAVSGYMDGQEPNASQQFRSQQMQFMDSIRFAVSGTQPQMPNQNANQPAQFSAAGRFRGSMATGADQFGNMYSSKDQNHNVIMSTGFSSNTTQSLQYQRMMQSQAQQQALYSRLNQQQSMSHRLSHPSIPEHQQPPYQQYPTQVTMSQTVPQVNNNMSMQNLPPYTNGGYQNLQSSQTPFQRQMSMPLPGQAYPEQYNQQMNQYTVGDQQVPSQAQPQQTDMSSTAYHFNRRNSFXLYHRTXSQPAPSYGPPGTAYQGQVNQMRNNIPPGQNPANAMIDGRTNTTAGYNYNNRTTGFPSQSAMQGLMQMPQRSRAAMTQSGAMPPSRPDHQTMGYGTNLRDSSRQNISQEMKYSTRNDIPKVTRAQSFSDPLALDNPTSTANSDSNYNPFSPLGSLEKAPSFASLLEQSSGSLNNLETTYTGSIPNLDLLGEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I820</accession>
    <name>A0A6P8I820_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296876</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560845.1">
        <property type="nucleotide sequence ID" value="XM_031704985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I820"/>
    <dbReference type="GeneID" id="116296876"/>
    <dbReference type="KEGG" id="aten:116296876"/>
    <dbReference type="InParanoid" id="A0A6P8I820"/>
    <dbReference type="OrthoDB" id="9993283at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560845.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18700" checksum="DD59CDB680992BB1" modified="2020-12-02" version="1">MSSADCCFSMCQSPIQAIIRPAMWCPGIKKLHSSNETWIIPNLTVEVCVDKLIEAVNDLGEKEKMHVNKVNREKSFVRIFSFTPNEWFDVVEIQFQPGREEGTIAKARSFSTGFLPTCCPLALIFNMILFFVPFHDQGANKARLNRVRSAMRVDIKLESDTSQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I927</accession>
    <name>A0A6P8I927_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300350</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565069.1">
        <property type="nucleotide sequence ID" value="XM_031709209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I927"/>
    <dbReference type="GeneID" id="116300350"/>
    <dbReference type="KEGG" id="aten:116300350"/>
    <dbReference type="InParanoid" id="A0A6P8I927"/>
    <dbReference type="OrthoDB" id="5981613at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565069.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32446" checksum="152D90C618A448CF" modified="2020-12-02" version="1">MNEIVTRWSSWSKLQRRVAWIRRFCRWIASKRTACNTGILSLEELNEATNVIVRSVQTTCFSDELSELKRKGEVKKTIPVADLRPLEVDGVLCVGGKLQAAENLSFDERHPMILPKRHHLSELIVRHFHEVTAHGGREQTLYEMRRKFWIVAGRSLVKDTVRRCIECRRMNARAMHQVIAPLPKTRVEAYQPPFTYAGVDLFGPMTVKWGRGTAKRWGCLFTCLNTRAVYLDVVPSLEADDFIMILRQFVSRRGPPNEIWSDRGTNFVGANNELQGLYCSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICE4</accession>
    <name>A0A6P8ICE4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Homeobox protein Hox-D8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC116298361</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562639.1">
        <property type="nucleotide sequence ID" value="XM_031706779.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562640.1">
        <property type="nucleotide sequence ID" value="XM_031706780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICE4"/>
    <dbReference type="GeneID" id="116298361"/>
    <dbReference type="KEGG" id="aten:116298361"/>
    <dbReference type="OrthoDB" id="5954982at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031562639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031562640.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27115" checksum="10FCA4B4B83F9CB5" modified="2020-12-02" version="1">MYDLYSASLNFTSPSPQYPNYCSYNTPSTQHSCAVNMQTQSKRDYRGYNSYNATSMNGSASSALASCARVPPLSHPPIQMVDRSVPHSSFYDDPYRYKIQNNYQTQSSFPNHVQYATPAGKDYCDDETRSEKSSDNDQDTDTDKPEDNKSKKRKDRTVFTKYQLMELEREFTKNNYLTRLRRYEIAMSLDLAERQVKVWFQNRRMKWKRTRGGTSSSKKNIGIVDRREDIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICX6</accession>
    <name>A0A6P8ICX6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wolframin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563040.1">
        <property type="nucleotide sequence ID" value="XM_031707180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICX6"/>
    <dbReference type="FunCoup" id="A0A6P8ICX6">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="GeneID" id="116298656"/>
    <dbReference type="KEGG" id="aten:116298656"/>
    <dbReference type="InParanoid" id="A0A6P8ICX6"/>
    <dbReference type="OrthoDB" id="5865303at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045400">
        <property type="entry name" value="Wolframin_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026209">
        <property type="entry name" value="Wolframin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098:SF3">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20053">
        <property type="entry name" value="WC-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02060">
        <property type="entry name" value="WOLFFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin cysteine-rich" evidence="3">
        <location>
            <begin position="579"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563040.1"/>
        </source>
    </evidence>
    <sequence length="833" mass="94120" checksum="CDA5C269118C5B97" modified="2020-12-02" version="1">MTDSIPTESKEKEVFSNENTEKQLENVKLAKQLLHEEGCKKEDAIELLVAASKACNKEATEMLAQCLKNGEGITSENKKAVEWCVNTPEAEKRLKHAMTELFMSLKKGGNDKVTKQDVKDALHEAKSQEKSSTSSGDGIQGSKEEELGLMSVLTSVMAIGGKDELSLREFMDTAMSYTRGAIPEMEIVLDKDEMEKYNQSSLIEKVLKYPHQTFEYFKFQALSTISKRGSSWLNSLIPKAQIQTLLLLYLYHQLSARVLWFIVPLVIFYIAMSGLIIFSLQMFHGRASLKKLKNFSHLLRRFDPRIDEKEAERKFIWKSIAPYIWFFVFLLVAVAVYPFCDKTWIPCSELSIISLFFTVSALRGLPDEYDDFTLYTLGLKVLTMVLCSFKDTKGLWVLCQPLLIIPLPYKLEMHISIPGVLHVAILVMLIIMAGRHSWRGIYKVLIPHLVCLLWWQMFTELFVHTTWQSLTRASIGWIILITMLPLVFVYIVGVFLVNFLQWFLILDLAMKLAVTAIVIAASSVIVLYSNLEIPEDVRRRRKQVMIVMALVVFCLLGPIFYVNYIPVKKGAHRGIKLTWKRYDAQCGPTAHKDHTEAALQGMCGDFEGEIVTWKGTVTSAKVAKVDNRFRTLVTAMPKIFRPTLRCLLGGEAEKDKQGDEKEPSLSFGWIFKRKSSTGCNLKSFDRYTFLMGVEFMSSEGPLAAMVTVSHKYYETMMKLSKGTNITIKATLNEGLGSGLITMDLRRLFIDGAPVKTEVAVEKEDLYMGVKQAGRYSVQFFFSPLVNQKGSFDYDDDDDDDDDDGGGDGDGDGDDTGSVKANKDDKNNNNQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFM3</accession>
    <name>A0A6P8IFM3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sodium/bile acid cotransporter 7-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565487.1">
        <property type="nucleotide sequence ID" value="XM_031709627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFM3"/>
    <dbReference type="FunCoup" id="A0A6P8IFM3">
        <property type="interactions" value="1641"/>
    </dbReference>
    <dbReference type="GeneID" id="116300711"/>
    <dbReference type="KEGG" id="aten:116300711"/>
    <dbReference type="InParanoid" id="A0A6P8IFM3"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027699770" evidence="3">
        <location>
            <begin position="30"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565487.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="37568" checksum="919C5007B4B0DD0F" modified="2020-12-02" version="1">MIAFIRKNWFLVGIVTVICLARFAPHIGAKGGILKPEYTVKYGAVSIIFFNSGLSLRTEDLKNAITQVKLHVFVQTFTLVFIPLLISQLIKLLALLSLNEWLLKGLLVVSCMPPPVSSAVILTKAVGGNDAAAIFNSAFGSFLGIFVTPFLLLVLVGSSSSVPYSSIFTTLSMTVVVPILVGQVFRYNDKVRNWMEETKPPFGTIGSCVLLLIIYTTFCDTFSSDVGDIDSTNLLAVVIIIFLIQCFLLFLTFYLTSMPESPFKPADTVAIMFCSTHKSLTLGIPMLKIVFQGYKYLSLISIPLLIYHPTQILLGGVLVPVVRNWMLEKQAAHKDKSTINGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHJ2</accession>
    <name>A0A6P8IHJ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase TRIM71-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566261.1">
        <property type="nucleotide sequence ID" value="XM_031710401.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IHJ2">
        <property type="interactions" value="1231"/>
    </dbReference>
    <dbReference type="GeneID" id="116301361"/>
    <dbReference type="KEGG" id="aten:116301361"/>
    <dbReference type="InParanoid" id="A0A6P8IHJ2"/>
    <dbReference type="OrthoDB" id="27136at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="385"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="498"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="542"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="633"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="192"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566261.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="79122" checksum="FBECA876FFCD2D86" modified="2020-12-02" version="1">MASLLENLKKDVQCSLCNDRFTEPKILSCCHTFCKLCIEIYVELTEKVFKCPKCKSKTPLPYLNSVEDLEPSLLHSRMVKVLEFVESEKICSVSGSHPPASWHCFECNRSLCDECEKSHSVFTKAHKTTRLNNLKKEDVALMLRGNYGHEHEAIYNFYCNDCDECLCFDCFKIKKCGIHNTTQIQDLISSKRSLLQQAFDHLKARQEEMQKQLGILKEITKTAKENGEQAKLEVQKTVKRLISSLEESEKELEREIEKKIKKAEQKXSKGQVVVXKTLSVLDYVCKVMENGNLNEMNEALIDTAGYDNSIDNPSRQESRFKFVCSKEVHALGNSGIGILKPILTDPVMSLIEVESEDLEALKKSALVVLTKTTTGKLNADPDDVVDVKITPEDGVKIKLKRTTDGKIEVEFIPKVAGQLTAEVQVNGNNVSNSPLVINVKPQKMEITSEFKMKGIQTTSSDFTGIAVNKKHTRVAVADKSSQCVYVCNTDGDLLLTYGSRGNGQDQLDNPHGLAFLNDTDLVIADFGNDRICIVNTDTGTLIRCFGQRGQGVGQFKYPRGVHVDEDGNIIVSDYHNHRFQVFSKDGKIQADWTKQGSFNPVSTVTHDGRFYVLDEHGCSIHVVEKKDGVLTRISTIGEKGSADGQLSTPRGLAIDNDHHLLVCDRGNNRIQKFTLDGRLVGKMDISNPGYIAVLKGSKSLVTAVKKVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIE7</accession>
    <name>A0A6P8IIE7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BTB/POZ domain-containing protein 6-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116301633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566577.1">
        <property type="nucleotide sequence ID" value="XM_031710717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIE7"/>
    <dbReference type="GeneID" id="116301633"/>
    <dbReference type="KEGG" id="aten:116301633"/>
    <dbReference type="InParanoid" id="A0A6P8IIE7"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031566577.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49756" checksum="369E2A95193D8D42" modified="2020-12-02" version="1">MEASAWQTKLSSFKERHLYAYNKSLFCDVELSVMDANGEKVTIPAHKYVLAISSPVFETMFYGESAETGRTIDLPDCTKEGLQEMLLYVYSDEVNITGSNVLDVLYLAERYMLPFLKEKCEEYLEKDLKPEDVFHVLPQIRNEKVEQKCWDMVDSDAERAVSSESFLNVSREMLCEVLGRDTMSIDEVVLFQAVEKWALNKLTEEGLGESMENKRAVLGEEVIKLIRFPLMSQKKFAEKVLPSGILTMDEVTQLVQIFNDLWPLRASFNNTKRGRYEVFMPNTRLQMIISPCNGHWSYSSLSIDAIDFKVNKPLFLVGVRLFGAEDCSYEVNLALYKSAQLIQQICSTFPTEDEETYGYYGFTIHLDEPVPLDPDVVYTIEATISGPDSYYGLQGRTTIAFEDVVITYLGKRKRSNGTSSKKGQFPSLVFRRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIV0</accession>
    <name>A0A6P8IIV0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA-binding protein Nova-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116301726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566689.1">
        <property type="nucleotide sequence ID" value="XM_031710829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIV0"/>
    <dbReference type="FunCoup" id="A0A6P8IIV0">
        <property type="interactions" value="2969"/>
    </dbReference>
    <dbReference type="GeneID" id="116301726"/>
    <dbReference type="KEGG" id="aten:116301726"/>
    <dbReference type="InParanoid" id="A0A6P8IIV0"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22435">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22436">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09031">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047275">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047276">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047274">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="49"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="307"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031566689.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="41455" checksum="B3118F35D7BD365B" modified="2020-12-02" version="1">MALENMADQFSTGVDASSEITDGDSRKRPLDASSDIRQPFKRSNFGAAKSPILKILVPNYAAGSIIGKGGQNIAQVQQSTGARIKLSPNNHYYPGTQERIGLIIGEVDTIITMLDFVIDKIRQEPQGAKVNSNITFDRERAKQMKIVVPNSTAGMIIGKGGTAIKSISEQTGARIQISQKDADSVAGERVVCVSGEEDQVQAACAIITAKVQEDPEHALNNNIMYTGLTTSRGGHSNGHFGSNLPLSALSGFGGLGLPNTGSQGSQAAAPNHILAQAALMQSGSNALSSALGMPPTTTATTSSSIHSSATLEITVPDELIGAILGKGGKTINEFMQYSGARIQVSQKGEFVPGTSNRKVVITGDVQAAQLAHFLITQRLQQVEAERLVSPPHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIW9</accession>
    <name>A0A6P8IIW9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116301525</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116301525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566458.1">
        <property type="nucleotide sequence ID" value="XM_031710598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIW9"/>
    <dbReference type="GeneID" id="116301525"/>
    <dbReference type="KEGG" id="aten:116301525"/>
    <dbReference type="InParanoid" id="A0A6P8IIW9"/>
    <dbReference type="OrthoDB" id="5984258at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031566458.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29560" checksum="28DBE79BC55F442E" modified="2020-12-02" version="1">MDSHYIDISSKYNYLYEPIHQQFRAPLIIKRLQLTPDDLLLDIGAATGQQAHLIWKQVGLKNPVTCVEPCHAFFEHASKLDGIVPVTQTAELFCDHLAQVGSQRRFNKVLLCSVVHHIDDIVKCVGQILDYLPKNGACFIISGLPCSEKSLSSLPLSVLQLQHLKENSNPFDIILPYVKSRDDVTTEVTNEEPTFRIPKSRWYYMIRNRYWSYFHRYTDEEIEESIKELDNGRFNGVKDDELITVAYEAIGVKMTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJD8</accession>
    <name>A0A6P8IJD8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116301843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031566855.1">
        <property type="nucleotide sequence ID" value="XM_031710995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJD8"/>
    <dbReference type="GeneID" id="116301843"/>
    <dbReference type="KEGG" id="aten:116301843"/>
    <dbReference type="InParanoid" id="A0A6P8IJD8"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="239"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566855.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58254" checksum="868A35B2B633E7F7" modified="2020-12-02" version="1">MVRWVRKYLYSVGRDSWKSAAAKTEFRFLFTTGSNLITASQQTNNSTEIAVILKGHSFSKKKVDQEPQLKLKNVFSNFQIHRKSTMFDSMSSREGTKVCRLYSPPPVLKNINTVNNCTALSLRVVPQRSFSPVLALLPCMILFVIIAMYWIKRRSSRAKTEKKSHAGKDLLLIKATTSLPTSLSLRQTSVGSKQSKQVDEAMDCSQKDKANNISYSTSNKAVRDLSTLVQGHVPLPHRFTNKVEIGKGGFGKVYKALDWTTNKIVAIKEIQSKKVKRFSENLVPREANIHKQLSHLNIVKMENYYPEGENFNLVLEYISGGPIYRLARTKAVTENDISCIAKQIFSGLEYIHSLQILHGDIKCPNILYTLSGQIKITDFGLSMKEEDLRKYKHLRQGTPHYMAPELVSRKPYGVKVDVWATGISLIELLQGTVPHCSLSYDRAMKRNASQGIRLLTNQNSYSQEAVEFISNTLKLRQKHRWHSYMLLTHPFLIKAPPPAALIPLIVKARNNNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJJ1</accession>
    <name>A0A6P8IJJ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116301672</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116301672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566623.1">
        <property type="nucleotide sequence ID" value="XM_031710763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJJ1"/>
    <dbReference type="GeneID" id="116301672"/>
    <dbReference type="KEGG" id="aten:116301672"/>
    <dbReference type="InParanoid" id="A0A6P8IJJ1"/>
    <dbReference type="OrthoDB" id="5985694at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="6">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031566623.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36028" checksum="AE6D82FF2BB7DD77" modified="2020-12-02" version="1">MSLHNDISVLDCGMQCSVTPGCRSYNYKNNTTPQQCELNNKTAEDEPADYEVDVAFNYYAEDLCVPNPCKNGGSCHHGGSPSHTWCLCTQDYDGNTCTKFVPLGALPKKPAQSCLHTNNSVGGVEDGPKWIDPGYSGTPFLVYCDMTTDGGGWLLVSNVIIPNPVQKPPRILTSSFHNISNYSDNQLFISATNLRQLKQLMPFSQLRFECYKREVGRKIDIITTKDSKGTAVVDYFTAKTDDRPDACGSFIPGSGDNSMIARECANWKLGKWGHSRKNEDRLFDHTFYVPSRYHWVLRVATFDCDGNSVHLTPGDFWKIYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJM4</accession>
    <name>A0A6P8IJM4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116301912</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566942.1">
        <property type="nucleotide sequence ID" value="XM_031711082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJM4"/>
    <dbReference type="GeneID" id="116301912"/>
    <dbReference type="KEGG" id="aten:116301912"/>
    <dbReference type="InParanoid" id="A0A6P8IJM4"/>
    <dbReference type="OrthoDB" id="5958366at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566942.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44217" checksum="66F31E1496B39C25" modified="2020-12-02" version="1">MDSNGSHQNLGLHYEGVLEKAGKRFFEGFRKRWFILEGKDLSYYKAPETTEQNLLGIIDMTRVKSVVPFKMINNSFQINTSTRTYTFTAPSSQSLTEWISVLRQAMQLESFSNKRARSSIRESVSEDGYEVVVSRSSRSDSKASSTSQRSFEDNDVYGDENVYDKIESSGSQSKADNKLEDEAAGSYESVGSFKRKNLQNKNNKPEVSGYGMVARQGSLPRNDQGSGVSEIGAYDVIGGTYEAEVQNEGNLYSQVKKPIASPPFEVTDSLYAEVENAGSIANSVSTGKSSKPNITVSNPMPVLVESDDDEEDEDESDARDTLEVKNNGLSKDPLPPPVGSIYAADEIKSLLQEIDGDVDEKSQEIKQISYKDDLLIPESCENAFSELKKFLVYLEATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJN8</accession>
    <name>A0A6P8IJN8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="3">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116302062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031567121.1">
        <property type="nucleotide sequence ID" value="XM_031711261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJN8"/>
    <dbReference type="FunCoup" id="A0A6P8IJN8">
        <property type="interactions" value="1567"/>
    </dbReference>
    <dbReference type="GeneID" id="116302062"/>
    <dbReference type="KEGG" id="aten:116302062"/>
    <dbReference type="InParanoid" id="A0A6P8IJN8"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031567121.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="46160" checksum="8F67282213058F1F" modified="2020-12-02" version="1">MLYHCSLYQFRHVGRFKTNIFAGSRLLRTTLAPLHSSRESSLCTNGRILHYKLYISNPAKNPDVAKVFHKFMSTASSTTLEKPGQKQQQLIKKAIPAVEEEEEVWRQQKVDLKLLPTYYMRLAKIRLTGMVVLTAMAGYALAPEAIHLDTFMWMSLGTLLCSSSANAINQWMEIPFDSQMARTQNRVLVRGLLSASHVLAFGIVTGAIGVTSLLTQVNGLTALLGGANLLLYTCIYTPLKRLSIVNTWMGSLVGGIPPLMGWAACTGSLGPGALVLAGILYSWQFPHFNALSWNLRPDYSRAGYRMMCVTDPALCRRVALRHSIYLIGLSTLLPLCDVTSWWLALDSLPLNTYLTWLAWRFYQQSDSKSSRELFRFSLLHLPVLMLLIMFHKKPKKNNRDVVDTLDVAIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJS4</accession>
    <name>A0A6P8IJS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116301970</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567001.1">
        <property type="nucleotide sequence ID" value="XM_031711141.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567002.1">
        <property type="nucleotide sequence ID" value="XM_031711142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301970"/>
    <dbReference type="KEGG" id="aten:116301970"/>
    <dbReference type="OrthoDB" id="5972008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029299">
        <property type="entry name" value="ALMS_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553:SF36">
        <property type="entry name" value="ALMS1 CENTROSOME AND BASAL BODY-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553">
        <property type="entry name" value="ALMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15309">
        <property type="entry name" value="ALMS_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALMS motif" evidence="5">
        <location>
            <begin position="1863"/>
            <end position="1996"/>
        </location>
    </feature>
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    <sequence length="1998" mass="218969" checksum="DF70428FCEDFE257" modified="2020-12-02" version="1">MASSATIPPEHNQWSPSDTVAQGIAQEYSSQWHILEQLKSSVAVVDPLADTSKTSRESVSPGNISDQDQEPTAKSKEVETGDTEKTEKEWFILPDALSSGHTSDAGSDSALEISDLRNEPSYSQSSNRTTPSSSTKTKELSMEKKNENDPYQEQWHVLEELKASVKAMQWSSNASESSFDVSHQSMPSRNSSKKEDFAEPPKRAPVANSNLVSGSVSSFGNTDDESSFRSGVSSKAAGSYINNSVGTTSLPVQLTQTSGYQDQQSRSAPSSFYQGTAITSDAHQAQNTSSDLSLESENLGFADLPNRPATIGNYGASDLANTSPFGTTGIPLQAMNIQVNTSQNIISVPSTFSGSGGDVALMSEGSDTLLSKGPMSARERLQPDGRDGPDVLAAPKTVQLVPSLVSYPLSAGSSSTDNAQGTVLQPSQGNSDLDIAKSSNLSQVGQLLVGDAAQSSPYSTSQLSGSTPVISGALGMSLHSNTSVGVPLSNAVDNSSVGIGPQLTTGLGTEDSNQPGSKGSVNSSLQSSFSPDQNKGSHPSSSPRQHGSSLTEVQSSMSHTNSATNITNTSWLSGGVSPTSQVLIDLPTGPTNQGMGSFAQNEIRDAVMQRIEAHTQITDFGSKVVPKEPTESSFSWSKPTGISGAYGTLDSRFVGNGQVAPLSSIPAIPARSYHSLPDTSQGSIPKTTQSITTSFDPTVHGDRQTSSNRHTMYPSQVDRQTTHNELPGSYDSYSLTTTQSFPSSTLTGKSAGYVYRTAATQSSAQNIPSRSSLLEDPGRSRIQKDIFSRPSAVDNIRSGLLNSEDDEQSPVSKLLGPKFKATQDYLNKLRNEKLQESSFRSTGSSDSESRVPLANLIEKPFDNGFRQRESSKEISHKLSTSSLSDNSYERKLESKQAWSVDTSDASESRSDRMGKEKDQXVKQHYHSFDHQTMSKTKDTSGNIYTRDVHSASLSPYDKTTPSTASTDQKSAKDSYLKYSQDSFPTSKNECLHEIQESLSRYETPLSSLQPDEKAWAQDVGHNVNKRTLYSTESNSLMSSYDEAEDTDDLLSYEAVLQGDIRYIRRLKDGKQERKSQETSSKGHFHSSSINSKSSLTPETTPGQLTGDLSSINGSVECDPLTRIPVSVGSSGSEFPSIEEETKRFHLSLGAGIVSPVIESENENYQRTPEETSDVGPRDDDDDAQLSSDVIEIEDIEEQEGRKEVLHPSERESLTTESSSSSTYQPYIPIALRQPASTERDSEVTGNSSLTYGVYDIRNSSGPGSTNRRRKAMGLTPIPGRVPKLMNGIVYVSPESSPLQSSMQEDLSTDEKSSKDDTLTSQSRIKSKSDVREKHSTSHRYSSQGGRPTGSRDRSSSWHSAEDHESRKKKPSRDNDESSRTRSRASSFEEAKVIDDYIGGRKLVQHGKSRNAKSRPKDGTHSDESPSLKEYSTSTKNADLNQMWERFQESLRSSPRYNRTDSVSSHLSRLSALLSKPLDTATTSSETEFDGKRFRKPRSHSYGSSSSKVSTESDQLYNEWVKSSSLSRQIKLRKLLETVNVGDVPTFPRLRHRDTTTTTTTTSSTPSDTSFSEAPESRNASLVTLPRSNRGFRKVSKTPVLVPSSQSRRPAEHDPSRPICICAIHKEKPAEPARVGPVNDKQLHRPRTLDAAVNVPSPKTPRRVRKKEGLVDVGVQTARDSDEELNRQNIRIKGKSRKHLKDENKLERVDSEKATAIGASTPKRKERYLASQNSQNQKRVSSVDSSLRSPEGLQDTTQEDSRLENTSKKEKSRSRQHRGRLLASQNSPVAKMNSESQHSPSGPTWFYPMTNRHYSHPARSTSVANKYSKPNLQTSVVKPDRLRSEEQTTKAFSPPAAAPSTSIQKLSLQEAFCFAKPDFIKRSRARLTRIEHNRTVRESGETKTKGQERVSKMEILAVSKPSVSKPLVNPKTEKLYRPKPRQMSKKEIKEMNLRLYNNLPEVKAQKADDRRNAFYKTNRLRAKLYDKRVRENLKKRYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK15</accession>
    <name>A0A6P8IK15_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="15">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302074</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="15"/>
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        <property type="nucleotide sequence ID" value="XM_031711274.1"/>
    </dbReference>
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        <property type="interactions" value="1153"/>
    </dbReference>
    <dbReference type="GeneID" id="116302074"/>
    <dbReference type="KEGG" id="aten:116302074"/>
    <dbReference type="InParanoid" id="A0A6P8IK15"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
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        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000284">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF93">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="42"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="17">
        <location>
            <begin position="425"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="17">
        <location>
            <begin position="524"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567134.1"/>
        </source>
    </evidence>
    <sequence length="636" mass="72941" checksum="C637B0F65477F6B7" modified="2020-12-02" version="1">MSKALTKDRYVGRYRTDRPIEVPKGPKEIGQIIEDVRAGKRYLRGKFLGKGGFAKCYELKDMSTQEIFAGKIVAKSLLTKPHQKEKMCMEIDIHKRISHRHIVKFHHHFEDKDYLYIILELCPRRSLMEMHKRRGALTEPEARYLMKQIIEGCQYLHNNKIIHRDLKLGNLFLNNDMEIKMGDFGLATVVKEGERKKTLCGTPNYIAPEVLNKRGHSYEVDVWSLGCILYTLLVGKPPFETSSLKETYGRIKRNEYYIPSKVQHPAQLLIIKLLRPDPSTRPTMAEILDDEFFQAYMPSRLPVSCLTMPPKFASSSNLSTLVSRKPLLELNSQDTGPVPVSRKADAYSKRKSLGIRVVGTESTMVQPGEAIAEEVKKEEEEEACQDYYLSSLLHQLENCLDSNPHLKSNRNLDDAEDPASXPVYWVSKWVDYSDKYGLGYSLCDNSVGVLFNDQTRLILCEDGENLQYIEKKGLETFHTMKGYPTNLDKKVRLMTFFRNYMKEHLLKAGGVPGMKEGESSHLPYLRYWFRENEGIVLHLSNGFLQINFFNDHTKIFICPLMGAVTYIDENKRMRTFPFKNLKDHGCSKAIHSRLEFAKKMVKKLIHRLECTACKDEKPGTAVCPAAVPTAVKVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL92</accession>
    <name>A0A6P8IL92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pollen-specific leucine-rich repeat extensin-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567731.1">
        <property type="nucleotide sequence ID" value="XM_031711871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302545"/>
    <dbReference type="KEGG" id="aten:116302545"/>
    <dbReference type="InParanoid" id="A0A6P8IL92"/>
    <dbReference type="OrthoDB" id="5990655at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027552510" evidence="2">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567731.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29041" checksum="80F521E0E36E1DFE" modified="2020-12-02" version="1">MFKFTIALLMCMVMLTHGLPLNKIVVEDAKPEEPAKEVEQPQQEEDQEKDEPAPEVEEDDKPEDNEANNEEEDAPEQXEDAPLTEETSEDEAPATPEEDEDEIPELEDSEEDEENEDLPEEASEDENEENAKDEPEETPNEEEAPKEDEPEETPNEEDPKEDEPEETPNEEDPKEDEPEETPNEEEAPKEDEPEETPKEEEAPKEDEPEETPKEDAPKQDVPEETQKEEAPEQEEAKKEASSEEEKIDDLLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IME6</accession>
    <name>A0A6P8IME6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116302750 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567977.1">
        <property type="nucleotide sequence ID" value="XM_031712117.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302750"/>
    <dbReference type="KEGG" id="aten:116302750"/>
    <dbReference type="InParanoid" id="A0A6P8IME6"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028191021" evidence="3">
        <location>
            <begin position="30"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567977.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37472" checksum="9818F5F6087F32D7" modified="2020-12-02" version="1">MGESMIPSGFLAFMLLYFAFSSHFLSSYGATNFTRSPNKTVVVTSPKPIKLEWNYTVDNKDDFKDNSPVWEYKSSSGIWQEIASEDGLDGWKWKISSECPNTLRPRVSKESVATLVIINTTRKDSGHYRCTLKLLSSEDIPSEVEVXVNDPIASPTPPSNPVTVNGSTPHSSTTKAVPTTKPTTKPKKEPCPDYPYKAIVEIGVTPITVGPDYLDWSKDKISEFFKKDPFFCDINVKKNDESLTITLVSKDKVTKEDVRRKVEAFAKTVEGDVKINILSVVIKGPPLRPAEIAGIVIAVVVLIAVIVIVIVVVIKKKKAKKNLEKQENEIQNKASSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP68</accession>
    <name>A0A6P8IP68_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of microtubule dynamics protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568642.1">
        <property type="nucleotide sequence ID" value="XM_031712782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP68"/>
    <dbReference type="GeneID" id="116303268"/>
    <dbReference type="KEGG" id="aten:116303268"/>
    <dbReference type="InParanoid" id="A0A6P8IP68"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568642.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26862" checksum="D7F529F87BEE991F" modified="2020-12-02" version="1">MGAENFTQLSSRMTEEADALYNKIPSNEEIESFIAKHEKTSDPELLWRLARLSRILSSSHPDASKKKSYCLKMCDFANKGYELNPNSAGCNKYYAVAIMEAPTGQSEKAKRVHDVRACFKKAVEIDPQDATALLMLGIWHFRVADLPWLLRKIVNAVHSNPPTATYQEALEYFEKAEKVEPNFSLRNLLMLGKTHLRLKDNKLAKEYLQKAVDHQPKRPENEEFHKEAQTLLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP82</accession>
    <name>A0A6P8IP82_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">von Willebrand factor A domain-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568657.1">
        <property type="nucleotide sequence ID" value="XM_031712797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP82"/>
    <dbReference type="FunCoup" id="A0A6P8IP82">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="116303282"/>
    <dbReference type="KEGG" id="aten:116303282"/>
    <dbReference type="InParanoid" id="A0A6P8IP82"/>
    <dbReference type="OrthoDB" id="5986492at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Hemicentin-1-like von Willebrand factor A" evidence="4">
        <location>
            <begin position="179"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031568657.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="75346" checksum="7AD43607D2F79BEE" modified="2020-12-02" version="1">MSLERCARLGILVVITIHIVSSLDLFSTMDLARDSIIKHSTFQTMGLRAVVVGRGKSGSTLTSSAVNHYSNKFLQVLNEIERGIAEGSQRGSRNSQQKLKLLKTSIQEAVKKKMYQFARNQLGRAFYLIHKNASTTGRSRRHRRASVASTVSTFVRDIKTSLPIDKYDEFFAVDGEVTLTFAIDTTGSMADEIAAAKQIAIDVINIKRNKPVNYILSPFGDPEMGPITFRDKSENASFVSDINNLKAKGGGDCPELTFQGIREALNEAPETGSPLYVFTDASAKDNDLVDDVIDFAMNLDITVNFFITGSGYPCRAGDTNFAKLAQATSGRVLRFKNANEMLKMSNYIGKSLPGFNIITTGSSPLAKRKRRSSGNKTYKFPIDESVETMLVCFNSDTRNDGRGVVLKDPSGTVITSEKVSLSTTTLYEIKTPEIGQWSLQISPSVISGKYTFDVKSTSEAIVDFSHYFLVTIQRPRSKVEIYTSNPIIGKSSELFINVVGAGTINRHTLKLELITEHNQHIQNVNLTSNDTDGKRYIATFLPPTRPLKLKIKGITKHGNPFERISHYIIQPKSVLLGLFFCKTENTIKRGGKSTTVFRLYNAAPVDKDLVIKVRDKRGFAQPLRRTRRRIRRGRMGFFSVSFRAPTNVAIGTDNTATVIVLVNNGEEKLIETIQMNVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQF7</accession>
    <name>A0A6P8IQF7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Schlafen family member 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569311.1">
        <property type="nucleotide sequence ID" value="XM_031713451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQF7"/>
    <dbReference type="FunCoup" id="A0A6P8IQF7">
        <property type="interactions" value="765"/>
    </dbReference>
    <dbReference type="GeneID" id="116303844"/>
    <dbReference type="KEGG" id="aten:116303844"/>
    <dbReference type="InParanoid" id="A0A6P8IQF7"/>
    <dbReference type="OrthoDB" id="5954683at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="entry name" value="Schlafen, AAA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029684">
        <property type="entry name" value="Schlafen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048729">
        <property type="entry name" value="SLFN_GTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155:SF30">
        <property type="entry name" value="PROTEIN SLFN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155">
        <property type="entry name" value="SCHLAFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="SLFN_AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21026">
        <property type="entry name" value="SLFN_GTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schlafen AlbA-2" evidence="2">
        <location>
            <begin position="259"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Schlafen GTPase-like" evidence="3">
        <location>
            <begin position="446"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569311.1"/>
        </source>
    </evidence>
    <sequence length="973" mass="110421" checksum="789852C129787E8F" modified="2020-12-02" version="1">MERAKRGKVLQMEKNNKKSNQPHNDESKEAEGAGDVDPQQRDVSIDDDGSSLESTSYSESIGSASSIPCQDELAKLAEIVIDFDINFNKDKSERKEEVKEVLKAEIALRNTSGGVIRINSTQKPAVKDRDDWMKDLYEKRKTLLGSECGEKDSIGDILDIKTNGAMTYIFVRKSSVTILTDDSHLRQRSEGRNYKVSLYSRICELLNRKKRRCVCANNPKFHTSFRLGETLSYETMTEEHKLLNPIRNENLANNLCTKLSDNVVAFANTQGGTVYFGIEDKHSFIKGQKIEDNEEKDNILLSIVECMERKLWALDSGEKVKPKAGEDYHIKFFPVDGAGDNTYVIAVHICAFPGTAVFKKEPECSVLDQENQTVKMEFKEWLSLHKPTSVGDENDQKKLKRQTCGRTVYYTVKDTIEDIYSDLIEGSPGTLKIRPKHAMHSRNRSLQTFFSCLNKMFEENKWEGITFIERCWGVNIGLPNTKPAEVIRDILVCSPSIPLLLVSLCKGEATSESLKYNIKLATKLKGILAQEGGCMEKFYVKPITLACSEEDDIGILDEMISHASVYPHAYRMSNEKYQAIIKALVPVLAKVNSSFKGFVGNHLFHLLTKEQYEILFENFESPKLMITGPPGSGKTVLAIERIHRLRRQGFSFKEVLFVCSNEVLEAKVRHIKVTNLDGKPEPLCLTYNYFGIISYLRIKHALAGVKHIVIDECQHFKQNPPTPQSTGGRYWWEILMDWCDNKNPPSLWIFSDSSQRIFKGPCVLDSLPDGFSHRQLSTVIRTTVKIHRFICERFMKNGPLIQLGHNLEGEDVKVLVPNQPEEEEEEEHLVTLVYLLISLLKDMVNKGVDPDTIGVLFTDRGEKAFYRKLFDEHTEHCRVKDGRAVSEHGIVFDTIRDFCGEDKDIIIGFCPHFDPNSGFQNNEALMVSLCSRAKLKLILILEDDQVANSFGLADCLKKTDIPFVKDEVINFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQS9</accession>
    <name>A0A6P8IQS9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116303836</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116303836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569304.1">
        <property type="nucleotide sequence ID" value="XM_031713444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQS9"/>
    <dbReference type="GeneID" id="116303836"/>
    <dbReference type="KEGG" id="aten:116303836"/>
    <dbReference type="InParanoid" id="A0A6P8IQS9"/>
    <dbReference type="OrthoDB" id="9970277at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005513">
        <property type="term" value="P:detection of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003930">
        <property type="entry name" value="K_chnl_Ca-activ_BK_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258:SF8">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03185">
        <property type="entry name" value="CaKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031569304.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23667" checksum="A94864232CF17A03" modified="2020-12-02" version="1">MANIKYSYVFWGLFGVFILALWIALYVGCVIPIEKSETFRATQCKTIYSRDVGHQKCPCTSSSDDGCGKSYSCLQIFVSFTVQYHNTSTPQARRGLLHFAENILHSNCSYEPFCESSQDLIDIELLSYFYKRGKNGTVFSCYYNEENETQIIEVNYNGRRLAILLPFAAVFIVSILVVSVLLWRRGCGCNRKRRPSRLSFVTATDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRI6</accession>
    <name>A0A6P8IRI6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl-CoA dehydrogenase family member 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC116303461</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2,3-saturated acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44704"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44705"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47228"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65059"/>
            <dbReference type="ChEBI" id="CHEBI:74692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:47229"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48216"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:64868"/>
            <dbReference type="ChEBI" id="CHEBI:74281"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:48217"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>tricosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48220"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:90118"/>
            <dbReference type="ChEBI" id="CHEBI:90119"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:48221"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568863.1">
        <property type="nucleotide sequence ID" value="XM_031713003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRI6"/>
    <dbReference type="FunCoup" id="A0A6P8IRI6">
        <property type="interactions" value="1103"/>
    </dbReference>
    <dbReference type="GeneID" id="116303461"/>
    <dbReference type="KEGG" id="aten:116303461"/>
    <dbReference type="InParanoid" id="A0A6P8IRI6"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000018">
        <property type="entry name" value="Acyl-CoA dehydrogenase family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="23">
        <location>
            <begin position="41"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="25">
        <location>
            <begin position="410"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="24">
        <location>
            <begin position="494"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="22">
        <location>
            <begin position="608"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_031568863.1"/>
        </source>
    </evidence>
    <sequence length="767" mass="86598" checksum="4929BC681F244F34" modified="2020-12-02" version="1">MEDQVGEVRKEHQFDKTKLHRYLNQNLLGFPKGDGELLIYQYRSGQSNPTFKLNKNGCLFVLRKKPPGRLLKGAHMVDREFRVMSALFQASFPVPKPLLYCSDTSVIGTEFYIMEHVQGRIFRNPSLPAASIHERHQIHNAMISTLAHLHSINWERIGLSDFGHHSKYLQRQTSTWSKQYDASATANIPSMEKLKNWLHSNIPQDTFKTVIVHGDFRLDNIIFHPTKFEVIAVLDWELATLGHPVSDLAYTCLPYHWPKQMPFQEMSLNGVTGIPSEADCISMYSNNAGLIITKDVWTFCLALNFFKYASIAQGVYKRSLQGNASAPNASIFGKVVEPLSKASFKIIEDNRSTDADDLQIPPEFNMLHISSKARHMYVKMKKFIDDYILPAEKIFLEHSSNLSTQWTIHPYLEELKEKAQKLGLWNLFLPAQSGLSQLDYALLAELSGRSPYAPEVFNCSAPDTGNMEVLHLYGSPEQKTMWLEPLLQGKIRSAFCMTEPGVASSDATNMECEIRKEGKYYVINGRKWWSSGAGDPRCKIAIVMGGSRDKDLPRHRRHSMVLVPLDTPGVTKIRPLQIFGYNDAPHGHLEIVFDNVRVPASNMILGEGRGFEIAQGRLGPGRLHHCMRSIGLAERALELLCERALDRVAFGKRLAEKGIVQEQISLSRMEIDQARLLVLKAAYMLDTMGNKAARKEIAMAKVVVARMACRVIDRAIQVHGGKGVSQDSPLPYFYALARSLRIADGPDEVHMEAVAKMELKQHLKSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRY3</accession>
    <name>A0A6P8IRY3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein 17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116304331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031569911.1">
        <property type="nucleotide sequence ID" value="XM_031714051.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IRY3">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="GeneID" id="116304331"/>
    <dbReference type="KEGG" id="aten:116304331"/>
    <dbReference type="InParanoid" id="A0A6P8IRY3"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44464">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44464:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="582"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569911.1"/>
        </source>
    </evidence>
    <sequence length="1302" mass="145548" checksum="0D9B2B2B5C6F5EEB" modified="2020-12-02" version="1">MSLMRQVGLLAAGCQPWNLDVCSASSTGERFAYCATLAVYIYELDQQFNEYKLISIMSEHKKTITSLCWHHSNNDIFATAGADCRICIWNVAEQKTIAILNSVKVIPTCIGWCPHEDEVIAYIYGRGPLYTWNQFSAGGGTVSKLLDSISFFSDICQFRWNMKKFGKIALGHADGSISVISPGNRPYKHYLRPDTVDDPDDEDPVTAIEWDPLSVDYLLVSNARQGVRMIDSNSMSVIMNFKLSSLAARIHTLAWIPSAPGMFVTGDTQTGALRVWNVSKSSPIANIKLKKTGFHALTVISSIGDHSTSNGHVQTSVSSTSAAFTPPSVPTMNDFALPPAQILCTFLDGGVGLYDLGKRKWNFLREMGHVETIFDCKFKPEDPDLLATASFDGTIKIWNVNTMAAVETSPGNEGIIYALSWAPGDLNCIAGATAKQGVFIWDITKKKIIKKFTEHGKNSVYNVSWNHKDSQRIASCGSDGYCVVRRVDGSPIKSYKHPGAVYGCDWSLNNRDMLATGCEDKNVRVYYLPASTDMPLKVFSGHTAKVFHVKWSPLREGVLCSGSDDGTIRVWDYTQDFCVLLLEGHTAPIRGLLWNPEIPYLVLSGSWDYTIRVWDARDGTCLDVIRDHGADVYGLTCHRYRPFTIASCSRDSTLRIWSLSQLASPLQIGVLVQSPWSEIISQSLEEAMVVHGPPLLSGRASRDLKVDIDKSLNNAHQTAIKLFSDFFMPPCGAKNLWDLVSVLTDEDDSLLPASYSKGIMHSKHLVKYKASEAQEIETVKISRLGSGLSTNSQDERLKDAANIHIRIGQLQRYCELMVELGQWDKALAIAPGVSMDYWKELIERRAEQLVKEDDDAXIPYCVASGNTKQLVSFYTSRGQLHDAFLVAQVACEAGFPHWLDKNASKLPDLKRNDHMLPKIQSDMAKQYQPLLHSTSNTLADWYYSKGQCVESACCHLSVGDVKLAMSKLVRGNELELAVGMGIVLQATKYPIMHXALELLSWKCEKLNKWREALNLLDLIPKNVEYLLALCAKCQGTPAEINELHGKAGFPSLEECLQKAEELCEQEKFFDAMKYYLLSSTPELALDIGLNLARDAMVKQYWGLEDALKIVQLLSCIRSDRLSQSRINKQRQELVALSTYIGALLAMRRQYKPIVYPLLKQTRHLLHRDKIELGVPSLQIQAETEAWLAFNQPANSSNKPTXEQTAVWERLHKRAGTQQNDLECGLDIATGSLLPSHTDVQQCYFTGERIKGTAYALEDGKSFISLNHALMWAKVYLMWPELFHPDHAVRRPTLQDYQIRFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS45</accession>
    <name>A0A6P8IS45_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Melanotransferrin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116303713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569160.1">
        <property type="nucleotide sequence ID" value="XM_031713300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS45"/>
    <dbReference type="GeneID" id="116303713"/>
    <dbReference type="KEGG" id="aten:116303713"/>
    <dbReference type="InParanoid" id="A0A6P8IS45"/>
    <dbReference type="OrthoDB" id="9981115at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13529">
        <property type="entry name" value="PBP2_transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000095">
        <property type="entry name" value="Lactotransferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018195">
        <property type="entry name" value="Transferrin_Fe_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF29">
        <property type="entry name" value="TRANSFERRIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00205">
        <property type="entry name" value="TRANSFERRIN_LIKE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028477986" evidence="4">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="5">
        <location>
            <begin position="24"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031569160.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="43115" checksum="FAFC1D480FC364E9" modified="2020-12-02" version="1">MRWFTVMILFVCTAVSANAEAKKFRWCCIKDEMNKCKEFKKAFPGIAQIAGVGQITPDCVSGDNKEDCMKKIKNNEADFVTLSGGDVLKAGKTYDLVPIVAEDYETLAGMGYYSVIVAKKDTTVTIGTLKGKKSCHTGYRRTAGWNIPIGYLLYNTTQGKANSGCDAQFASNYFSKSCVPGAPKLKGLENLCALCPKESNCESSADKNTYSGYHGAFQCMADKKGDVAFVKHVTTAEVLNYASAKYGKMSDYKYICPDGTTKVVTQEAYEDCSYGRRPSNAVVTRTTSDNKDFVNILVTASKYCQPNTTASNCSGFLIFESSKYVPEKSNLLFRDSTKKLVSVGNKNTYDKWLGAGYIHALAVQGGPACAVSEAAMLKPFSYLFVVCIILGKVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS55</accession>
    <name>A0A6P8IS55_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116304406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570001.1">
        <property type="nucleotide sequence ID" value="XM_031714141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS55"/>
    <dbReference type="FunCoup" id="A0A6P8IS55">
        <property type="interactions" value="1729"/>
    </dbReference>
    <dbReference type="GeneID" id="116304406"/>
    <dbReference type="KEGG" id="aten:116304406"/>
    <dbReference type="InParanoid" id="A0A6P8IS55"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000164">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000258">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="393"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="557"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="802"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031570001.1"/>
        </source>
    </evidence>
    <sequence length="915" mass="104905" checksum="0999776250819F4A" modified="2020-12-02" version="1">MALLQWRRFIFFDKEFLKDHETNQPYERLKDINISACSSGRGQMIFGDNSGSIHFLDRDLQLSSFKAFEIKASHLYQLKQHNILVSVGEDEVGINPIVRVWNLDKTDKLGNPVCCQMLRAIPGNKPVAVSCLAVLENLTQMAIGFDDGSVVVYRGDITRDRHSKQRMIHQDKHPVTGLSYRQTTGSTILFVVTTDTVISYNLSSKDFKEVLDTHGCSLRCSALSDLSQEQQIIIARNEALYFYQSDGRGPCLAFEGEKQMITWFRGYLVVVSKDSKIQRPAPGLNSENKVANMVTVYDIQNKFIAFTGTVTEVLDVLCEWGNLYIVTTDYKIIQLQEKDTQTKLEILFKKNLYAMAISLAKSQHYSDGLIDIFTQYGDHLYSKGDHDGSIQQYIKTIGHLEPSYVIRKFLDAQRIHNLTAYLQALHEQGLANADHTTLLLNCYTKLKDVTKLDEFIMSEKELNFDVETAIKVCKQAGYYKHAVYLANKFDQHDWYLKIQLEDLKDYQKALEYIARLDFYEAESNMKNYGKSLVNKVPDEATNLLKRLCTDYRPSQGDVKTGSNKPQKARPEEFIHIFVHQKAKLIEFLEHMIQVQPISSSLLYNTLLELYLNNAAHESNIQSQVGHEKKALDLLTNTEAGYDLDHAMVLAQMHHFKAGILYLYEKAKLYQQILHYHMEQNDYHNVIDTCKKYGVQDPGLWVQALSYFARKETDCKTQIMEVLSHIDKGNLMSPLLVLQTLAHNSTATLAVVKEYIIHRLQTEDELIAKDERLIRQYSEETEKMRTQIQELKKSAQVFQGAKCSMCSRPLDLPAVHFLCQHSFHQLCFESYADNDNECPICAPENKKVLDIIRTQEQTKDLHEQFHNQLERAPNGFSVVADYFGRGVFNKVTLVTTGQGRGAPLQITERDRAHLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS66</accession>
    <name>A0A6P8IS66_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116304251</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031569819.1">
        <property type="nucleotide sequence ID" value="XM_031713959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS66"/>
    <dbReference type="FunCoup" id="A0A6P8IS66">
        <property type="interactions" value="1412"/>
    </dbReference>
    <dbReference type="GeneID" id="116304251"/>
    <dbReference type="KEGG" id="aten:116304251"/>
    <dbReference type="InParanoid" id="A0A6P8IS66"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="301"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031569819.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="44747" checksum="7B6B3D7D32AF42B9" modified="2020-12-02" version="1">MAATMIKMSRVPRNFLFTHSRRFSNNSSHPHLHEVVIVSAARTAVGSFRSKLASVPATKLGTVAIKGAIERAGISPEQVQEVYMGNVCTAGEGQAPTRQAALGAGIPTSTPCTTINKVCASGMKSIMMAAQSLQCGSQEVMVAGGMESMSNVPFLVSRDAPTYGGHLMEDAIVKDGLWDVYNQIHMGSCAENTASKYNITREEQDEYALSSYRRSTAAWEAGKFKNEIVPVSIPQKRGKPDVVFQEDEEYKNVNFDKLPTLRAVFKKENGTITAGNASTLNDGGAAVVLMTREAAERLNVKPLASIIGFADAAVAPIDFPIAPAAAMPKVLKQTHLKKEDISMWEINEAFSAVTLANIKIMDLDPSKVNIHGGAVSLGHPIGMSGARLICHLVHNLAPGALGLAGICNGGGGASAMIIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU00</accession>
    <name>A0A6P8IU00_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570519.1">
        <property type="nucleotide sequence ID" value="XM_031714659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304871"/>
    <dbReference type="KEGG" id="aten:116304871"/>
    <dbReference type="InParanoid" id="A0A6P8IU00"/>
    <dbReference type="OrthoDB" id="5956142at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570519.1"/>
        </source>
    </evidence>
    <sequence length="760" mass="87049" checksum="2F6EE0EEC16C0195" modified="2020-12-02" version="1">MDSENCEQTASSTFEIITEKDRRRFSRQDLIKKSKYILLFTCLLLVVAGITVALVFFLPRKASDSQTVPKEGESTSNKTDKGSNANQLFDNFLTKVHDAYYEIYLDEIFIKQNVTNDEIRENFRPFDFSPAALKRAADTAXQLRSELDSLLTDESEASLTQRELRALYEARTFLRYLRGPYDTMYYTGDWMLGPNTMAWQPIGTSLTFLGIAAKYYLQPRSVEEAEKFIELLRQQRASXVQYMENMKIGVKAGMVRNIEACRGGLLRFKSRFHPDFGGNLESIGVTNSFFKDFTNEMEKEWVAKHGXNFTTSLKEAADRYXGKPLSELIRYMETEHVQHCVPSNVSSGLASLPLTHVYLNGSQDLSQPTHPYLPSGERLNGSNSFVKLLPYFTTNXITPKEIKELGEAKLKELYGKALTLARQXTNETNTSMAVKKFRALLTHRSQYFNNKSFPSNESIENAYLKCFDDASAQLHCPERWEAFTKWKESTTSINKILHEKIKPLFYTHGKKKTTLSNACTIEVQPNFNPCSSYHNYQGKGCGIHFLPFFVDNYGPKFSDWTTTAHETEPGHDLEVRGYEKNFRGNTKDNIEWLTQNTYFSGFSEGWATYSESPLVGEDVDAYRDDLMSKYGMLQQEIIAALRLIXETGLHYYGMTRTEALKLFDDYAWDTSDIAQKEITRYQSLPGHSVSYMVGQTALMKARKFAEKELGXNFTLPEFHYQVLHQGELTLDYLDRYIHHYVACVKSNKDPKGQECNDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUP4</accession>
    <name>A0A6P8IUP4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031569900.1">
        <property type="nucleotide sequence ID" value="XM_031714040.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IUP4">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="GeneID" id="116304321"/>
    <dbReference type="KEGG" id="aten:116304321"/>
    <dbReference type="InParanoid" id="A0A6P8IUP4"/>
    <dbReference type="OrthoDB" id="5988573at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569900.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40609" checksum="543ADDF0A909F43D" modified="2020-12-02" version="1">MTSYYIFRSWYSRWLFKTRRAKKPICILVVLLLIGVFAFYLSMSRNISSLLQDPVRNCISNSKKCPYMRQFDGTSANGPTKFPLIMPXVEPNISCEDRKLFIAVIVNSASDEQHQLRRMAIRMTWGGSTEIQPRWRVFFALGINKHTAVYLKNRWESLKYNDILIGNFLDTYKNVVIKTFMSHYWAYFRLNCQYILKADDDVYIRVPRLVEWLVGPANLPTRFYGGYLQQSLEVVRNPKMKWYLPKEVYNETHFPPFLKGSFQVVSTDMLPSYFHYTQFIRKPFYTDDAYFGVMARDLGLNATQIPSFLFYHPQTDEQLLAAIAFGHQVDVTGMLRYYSRYELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVN6</accession>
    <name>A0A6P8IVN6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116304557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116304557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570175.1">
        <property type="nucleotide sequence ID" value="XM_031714315.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304557"/>
    <dbReference type="KEGG" id="aten:116304557"/>
    <dbReference type="InParanoid" id="A0A6P8IVN6"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031570175.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="38846" checksum="F5D22F80E85EFA9F" modified="2020-12-02" version="1">MTDRPSNQETLQTPLQGSLVSILDFCRKEADIMKSLILLTLLGSLFVQIQGQCIGRYRCQNGGICANKSKTCTCPQDFAGAQCERKKLGSKINPAPNAQAILDXGESEGSGMYWIQPPGESIAAQTYCDMTYSXGGWMLASYGYVSSVGSSLLNKAIPNMNNPMGYAWRPTRRAGKNGVINLLHGAVMMARNATYMMMAAGNNPNSGGIDHFSHVYRIDLRQNPYKITFANHNRYHGAVGANGIPKMHVTDFLVEGLKGDVGEFVRYGLGESLGVTWGDSYPTGYGFNDLGTEHSSWTKGPFFPSVHSGDGHSGCSSAPCKTFQPDVHRGSETYVHRGWYTASGTVNXIGQTSIWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVX8</accession>
    <name>A0A6P8IVX8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL20m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L20, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116305477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571264.1">
        <property type="nucleotide sequence ID" value="XM_031715404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVX8"/>
    <dbReference type="FunCoup" id="A0A6P8IVX8">
        <property type="interactions" value="931"/>
    </dbReference>
    <dbReference type="GeneID" id="116305477"/>
    <dbReference type="KEGG" id="aten:116305477"/>
    <dbReference type="InParanoid" id="A0A6P8IVX8"/>
    <dbReference type="OrthoDB" id="10251781at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.20:FF:000001">
        <property type="entry name" value="50S ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_bL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031571264.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14639" checksum="7E7C5F86F819661A" modified="2020-12-02" version="1">MVRGGPADRTVRRAKIFALAKGFRGRSKNCYSLAVRRVQKALQYQYVSRHLKKRDMRSLWQTRINIAGREHNINYSSFMYQMARCNIQLNRKMLSELAIHEPRSFKSLADLAKRRLEDGLLAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWF0</accession>
    <name>A0A6P8IWF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Loricrin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570383.1">
        <property type="nucleotide sequence ID" value="XM_031714523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWF0"/>
    <dbReference type="GeneID" id="116304743"/>
    <dbReference type="KEGG" id="aten:116304743"/>
    <dbReference type="InParanoid" id="A0A6P8IWF0"/>
    <dbReference type="OrthoDB" id="5987530at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31535">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31535:SF3">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028274401" evidence="2">
        <location>
            <begin position="26"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570383.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="41651" checksum="CCCA223E8CF36DF9" modified="2020-12-02" version="1">MKANINEFFLDLIVIAMALVSRVFAEAGSGNIFMNDNENRASGTFLKIKSHAILTNKITSKKVQSAIDCAFVCFQTPRCLSYNLGKTKQRGTFICEPLNTTHMDTPLIAMPNYTHFRNNTTKKSFTNQGHTGRTGPIQKFVVQQAGYYFIEAAGARGGTLSCNYGSFPGTYLGGKGATMKGVFFLAAGTVLKIVVGHRGGDAVEVKGGQSTKQTAASLGLSVEDNAGTGGGGGSFVYTSTNKLLLAAGGGGGAAHHSPGIDGQITTAGSPCSKEGVFDSVNVGGKDGGPGHCNTAGASHHGGVGAGWNGKGCARLTSKHGETGGSRLNNWIGGSAGGMNSGNNGGPPPGAVGGFGGGGGGAEDSGASGGGGGYSGGGSGNKEMYAGGGGGSFCGGISCTGAVGGNTNDYGFVNIIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXM7</accession>
    <name>A0A6P8IXM7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein DDI1 homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116305976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571852.1">
        <property type="nucleotide sequence ID" value="XM_031715992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXM7"/>
    <dbReference type="FunCoup" id="A0A6P8IXM7">
        <property type="interactions" value="1839"/>
    </dbReference>
    <dbReference type="GeneID" id="116305976"/>
    <dbReference type="KEGG" id="aten:116305976"/>
    <dbReference type="InParanoid" id="A0A6P8IXM7"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000005">
        <property type="entry name" value="DNA damage inducible 1 homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031571852.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42643" checksum="A82B0B0D82C2D0E9" modified="2020-12-02" version="1">MKITVTCEDDSLFTLEISGDLELENFLALVEFELGIPASDVIVWYEGNHLNELKKTLSDYAVKEGDVLLLRRKGTFSSRNAGRGKSDMVIDWGHIPVPPTGNAGPSNQVNMQRQSASSAEENPEAIRQMFLTDPHQMSLLKERNPELANALTHPQMFAEVLKKQRQELHERNMQRIRTMNADMFDAEAQKKIAEEIRMSNVNQNMEVAMEYSPESFAKVIMLYINCTLNGYPVKAFVDSGAQMTFMSSACAERCHITRLIDHRWSGIAQGVGQQKIIGRVHLAQIQIENNFLPSSFSILEDQVIDLVLGLDMLKRHQCCIDLKDNVLVIGTTGTRTPFLPESELPSNARLSNEAESEAKTQEMEDKNLAQALARSVDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXR8</accession>
    <name>A0A6P8IXR8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">F-box only protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116306080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571974.1">
        <property type="nucleotide sequence ID" value="XM_031716114.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IXR8">
        <property type="interactions" value="3087"/>
    </dbReference>
    <dbReference type="GeneID" id="116306080"/>
    <dbReference type="KEGG" id="aten:116306080"/>
    <dbReference type="InParanoid" id="A0A6P8IXR8"/>
    <dbReference type="OrthoDB" id="427974at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19676">
        <property type="entry name" value="UBR-box_UBR6_FBXO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000035">
        <property type="entry name" value="F-box only protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000175">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047504">
        <property type="entry name" value="FBXO11_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="UBR-type" evidence="10">
        <location>
            <begin position="766"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="7">
        <location>
            <begin position="766"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571974.1"/>
        </source>
    </evidence>
    <sequence length="868" mass="96432" checksum="7C3F0373CFEA369E" modified="2020-12-02" version="1">MSCPKKXRLCTDFYRNTKLRSLSSKALKCSHVSEKKESVSKVQQGKVRKTRKTSKNLRKSGMEKVQPHLYKTVNFQKPLEGSSCKLRKITTLFNCKPLLNGQCYVKAAPDELLLQIFSFLQATDLCRVAQVCSRFAAICRDESLWKQLYFRVFDMDKPFVKTKDGLIVTKEPESVSCWKESFKMLRNVHHVYHEKTTSKMYRKNNNKHHQSIQEAINSAPDKSFIMVHAGVYQESLIIGKPVAIIGVAFGDVSAVQIESCLTTTVSFEMGAREALLGHVTVKHTVNPSSQYSKNGCIEISGECSPLVFHCKLTSLSHAGATVYVHGKGTRPVVSNCYISDSENVGIFVTDNAQGLYEDCEITNTKLAGVWVRSHANPIMRRNHIHHGRDVGFFIFDQGMGYYEKNDVHHNRIAGFEVRSWANPTVVGCIIHHGMTGGIYCHDDARGEFLENKIHSNKYAGIWITSQSNPTIKNNEIFDGQQGGIYVFGEGRGLIEXNNIHDNALAGIQIRTKSNPIVRCNRIHSGLHGGIYIHEGGQGLIEENEIFSNTLAGVWITTGSSPTLRYNRIHSGKQVGVYFYDGGCGTLEENEIFNHKYSGIQIRSNSNPLIRRNKIWGGQNGGVLVYNEGMGLLEENEIFDNAMAGVWIKTDSNPVLRKNKIHDGREGGVCIFNGGKGVLEENEIFRNNLTGVLISTSSFPVLRNNRVYDGGAAGIEITNNAGGVLEDNEVFNNRFDGICLATGVKPKLKNNKVYGNRGEVKDAVDVGLCLFQVSGNSCYPMHDFYKCNTCGTSDGFAICVSCVNKCHQGHNVSFVRHDRFFCDCGAGSTGIKCHLTGEKIRPTVSCSSRHAQRTSRSEEERGSDELSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYI2</accession>
    <name>A0A6P8IYI2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC116306618</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116306618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572561.1">
        <property type="nucleotide sequence ID" value="XM_031716701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306618"/>
    <dbReference type="KEGG" id="aten:116306618"/>
    <dbReference type="InParanoid" id="A0A6P8IYI2"/>
    <dbReference type="OrthoDB" id="2015116at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027560696" evidence="11">
        <location>
            <begin position="18"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="14">
        <location>
            <begin position="150"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="13">
        <location>
            <begin position="617"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="681"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="14">
        <location>
            <begin position="728"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031572561.1"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123511" checksum="50214B4383E6AEBE" modified="2020-12-02" version="1">MNFLLVILVVLACSASGKVQKRESQSDEEQGDGYQEQVKSCPALHFGAGVTVDPPSCADGPRPSGTLCHFSCSRGYRVQGPPMSVCHDDGSWLYGHRQINCLDINECKFRKGGCSHTCVNTDGGFYCKCPHPLVLDKDGKNCRAVGLVLNCTAQNIEIIIPKYALSDLQGDYLQLRDPSCQPRENRTHYIFNTELNGCGTTRRHTKNFIVYSNRVTEKAVARHGLITRVGEGEFNIPFCCYFLDNGIVSSVGYKPLVXELVLKEKGYGKFKLRMDFFRTKNYQTEYTWDDFPVSVYLRERLYFEVSIDSIDDSLVVFAGNCCATPTRDHNKAGRFRHELIHEGCIVDSTTQREPSPSPHKQRFSVEAFKFVGKFPFVYMHCSVIVCKAGDPNSRCSKGCIPGIHRGKPMNGPYAKRNDIPKSHDTPNTSNKKSPIPESRDAPEIPNKDVQKKAPIRHNRSIEKHGHVLVKKEKDHKYLLSKGPVSLLEEEPEVERAADDEKIPETKLSEDVEEADENLGNKKSKSGEEQKAASTTTILLIALTAFTVLALLGVLYIGRKVKQASNRGLYDYKPMKSCLPRESKLAFSGGISFKMMLFWILALVIPSLNAQDIDYIDKVCPPLRVASGVSVVPPTCTHDKMRAGIVCSFSCNNGYRVHGPPVKECTDGGTWTDDHMNISCTDMNECRIRNGGCSHTCINTVGSYRCECPSHLKLHEDGKSCKAEGLKLNCGAKEMSIVIPKNIIHNLHHEHLRLNDPSCVATSNGSHYILSTKLTGCGTTSRQIKSYIVYSNKVSEEPDKSSNKIGRVLKGEVQVPFCCYFHNQEILHAVGMRPGNRELYIKVKGRGKLKLKLDFYKSKGYGSVYTWDDFPVSVLLRQRLYFEVSLTTKEKDLEIFADNCCSTPTRDHEKSKYLRHTFIHNGCPTDKTVRFHSSRSKTTQRFSLEAFKFLGDHPFVFVHCHVLVCDAKNPNSRCKKGCIPGKPRAKSRKTKRDVSVSSLKKMSAVTLSQGPFLVDKETRKETKRGEIPVPKMTREKIMKQNNEKEEKETSEERGFPHVGSVLLIALTVASAMALVGVIYISFKSRQVVPFXYNQLTTRSDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ70</accession>
    <name>A0A6P8IZ70_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anillin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572487.1">
        <property type="nucleotide sequence ID" value="XM_031716627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ70"/>
    <dbReference type="FunCoup" id="A0A6P8IZ70">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="GeneID" id="116306547"/>
    <dbReference type="KEGG" id="aten:116306547"/>
    <dbReference type="InParanoid" id="A0A6P8IZ70"/>
    <dbReference type="OrthoDB" id="5915976at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01263">
        <property type="entry name" value="PH_anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037840">
        <property type="entry name" value="PH_Anillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF23">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="891"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572487.1"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114085" checksum="1D63B40791DF7161" modified="2020-12-02" version="1">MDPFTQKLLERTQTRKEQLAKKKEELAACRNKRNAPAAPSPVKPRRPLSEDNTDDKDKLIDDNQKRRINSDGSVPKTPKEPTTPKAPITPKRATMPKAQSVLQGPSTPSSVTKVRGGVEIDTSSPSIQARREMLILMQQKDQENKTTPKKHWKKALDMNSNENSSPTVAARSAIFAQDKDSQPIFPKPSVSTPGKISAERNVFEKNPVSVEVKAVKTDAAAPPKPPRTIDVEKTLTREKSSSKRKAPAPPTSSSGGQKSDSEAGDTPVPKPRSESKVVGNDNYDQTIVSVKCADEKKPAKRERLGEGDTHSTERTNAKDEPTPKPRKRRSAESTTGGSENSSTGERNKNLEDERTKRREERKKARMESRERGGIMSVTAQAVEILEGKNEAIPVEVNSVCTPRSDQKSRAKVTVVRSESSETTAAVKQKDASSTSKAIPETIAKPEEICDAILEAVVYDEPKKPISKSTVKPKEGVSEFKPSRAAPTRPPPPQGISRFASQTSINSGLDELNETVNLNDVNIHEMTFTFDFSTFDKIQEDRETKFQKSFDEQQRELVKEKRETSCSQSSDDSGIVSPYIYEPKTKLEVEQANMGVYKSGYNSESGDPYATKMYKKAKPPVPERPKPVQDVIKELLDEAASQQNIILQTSQALNVCDSSNDIFKGSQEEVEAERVLLLASERKQACLNEHHRIKNKKNESKKDCNKDASNACTSTISIAGIRLSLKQEFMDVLRVGIRHDLGVFHFVCHVQNGPLEITSTKSLSINDCNEGNYLMFPDKFVLENVNPDFAVVVRVFGMHVQKYVPSASSAVQKGKFFPSPKAAKTKRHGIDRASPGATPMPVFRNSNFKLIGSTRVTLSQIGSKKWMLDGVAEGCPLKDYIQMKVHCTPQYTSHVKGFLTVLEDVGGFSAWQRRWCVLEGGLLSYWRYPGDETTQAPVDTLDIGQCTSDHITTVPRDLCARPNTIEVCLKKNNDQVKFLLACDTKEDRITWVNCLNDAMCDMKAWTKSNKGPLYPELGHVSDTKEQHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZC1</accession>
    <name>A0A6P8IZC1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurexin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571278.1">
        <property type="nucleotide sequence ID" value="XM_031715418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305490"/>
    <dbReference type="KEGG" id="aten:116305490"/>
    <dbReference type="InParanoid" id="A0A6P8IZC1"/>
    <dbReference type="OrthoDB" id="5989513at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF49">
        <property type="entry name" value="AXOTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028264773" evidence="6">
        <location>
            <begin position="25"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="249"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571278.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="72513" checksum="D490D1D351498871" modified="2020-12-02" version="1">MNHLTWRSFLAAVLCTVCVTSVWGATTFDDLKTSFAQYNKWIPPSSSQGIEGKISFFFKTHVXDSILLYQDDGNRDYLSVELLSAKVLLRFGVSGNSVRVQIGHDLADMLWHKLVIRLDNDRVILTLDQNLTRTATIPRXNEALLGNSTGILYIGGLPRSLSLSLLSSPQVAFKKRFVGCIKKIMMTNTENVFERAVLIKSKGTKSGCLNECRVRNPCLNNGKCVNRFSKAKCDCSGTGHEGKRCEKEMLRLHXSTADYLVYDMSDRPQATRQDHINVHFKTSKKNGLLLQTSFSQDYVTIKLSNGRIVVEWNLGSGKLELFIGNNLHDDLWHMIDVRRFRRNVKAILDGVVTKESICPPSHSTFNMNGGQSKVFVGGSQTVVEQDRFEGCLRKVVFGGVEFISKLKTNDPRFSVVGTKVWSCRVPATLSLTTVPVTTVPIVTRSTRLRGRKRNRQGRKRVSNGSNNKDKATVVIQLDTQAPKTTTPRVKTTETHSTKKRQKPSTCSPNDIRCVMKTQADVNSPRTKKPTEKAVIKSDPCRKFKNCTKGADNTASPDHPTGNASTTGTPKIQALNEATKEGGLGNIPTAIGLVVGSILSFLLCGFISYRYSKHREQKHRRAHNIKIEVRDEEEQRKDYDGFHQDVLVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J063</accession>
    <name>A0A6P8J063_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GST class-mu</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116306869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031572852.1">
        <property type="nucleotide sequence ID" value="XM_031716992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J063"/>
    <dbReference type="FunCoup" id="A0A6P8J063">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="GeneID" id="116306869"/>
    <dbReference type="KEGG" id="aten:116306869"/>
    <dbReference type="InParanoid" id="A0A6P8J063"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03075">
        <property type="entry name" value="GST_N_Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000003">
        <property type="entry name" value="Glutathione S-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000019">
        <property type="entry name" value="Glutathione S-transferase Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="90"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031572852.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25145" checksum="78AECAC0148D9B33" modified="2020-12-02" version="1">MAPVFAYWDIRGLAQPIRLLLHYIELECEDKRYACGPAPDYSRESWLKEKFTLGLDFPNLPYYIDGDIKITQSNAILRHIARKKNLCGETEKEKVIVDMLENQLMDFRNGFVGLCYNAKAYDDAKPKYLENVVPKIKAFADFLGEEKFFVGEKITFVDFVMYELLDQHKVFDASLLEPHANLKAYLERIEALPAIAAYMKSDKFITRPINNPIARFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0M9</accession>
    <name>A0A6P8J0M9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573019.1">
        <property type="nucleotide sequence ID" value="XM_031717159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0M9"/>
    <dbReference type="GeneID" id="116307016"/>
    <dbReference type="KEGG" id="aten:116307016"/>
    <dbReference type="InParanoid" id="A0A6P8J0M9"/>
    <dbReference type="OrthoDB" id="10285614at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573019.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="37798" checksum="867519E7AAA5FE6E" modified="2020-12-02" version="1">MTALSQAKSSQLLVTGALMVIFGSGIFALLYVIHEDKYDDDENSGIFDRYSAFWTATPVVLVGLIGVLAGITKKNIWVSLYMIGSAVATVLSALVAIIIGVRVSGIRVACGEDTECKNSDKAVIMGTIVLLASILVTIAMWAGVKACQSKWGPGKHIPSLHVVGEFRTANGPTSPPTVVEVHSKSHPHSPEIAVAIATTSQQESKPSPHESVERDESHEYDDVMPKPTNGVNDSHQDENTNPRGDGTEGSDTGYETVSQDTNPRGEGVRIEDDNDDAGYEAVNPVKDHKYENVRLANNTIGDVPDKISIEMPTEDESPKVVEVHRDPIQDGCHSNTHDNKGFEVDELTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1F6</accession>
    <name>A0A6P8J1F6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116307319</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116307319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573367.1">
        <property type="nucleotide sequence ID" value="XM_031717507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1F6"/>
    <dbReference type="GeneID" id="116307319"/>
    <dbReference type="KEGG" id="aten:116307319"/>
    <dbReference type="InParanoid" id="A0A6P8J1F6"/>
    <dbReference type="OrthoDB" id="5989905at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031573367.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="27256" checksum="CF51CB35777F3BCA" modified="2020-12-02" version="1">MFLRIMGLLFGQVIDKVVNEDKKEQLVNEMDRIGIPFKFYDVRGENCEDGETKFTKLDGNDLRKVLNLLDVKKVLEGILSVNTQDVEMLWKGFQMLLDSISSNPGDPHFLQPEEFKRRAREWGHLYLYVNYPEDLTPYIHAFVYHVPQFMAKYSCIKPFSCRQPVEKKNMSKTRCSTGLHRRVDEDQSTQYRSWKERTGPWLPRRWISLERKENIENIMLLLKFIKKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3F0</accession>
    <name>A0A6P8J3F0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sedoheptulokinase</fullName>
            <ecNumber evidence="10">2.7.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbohydrate kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116308288</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a modulator of macrophage activation through control of glucose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16802"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.14" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031574536.1">
        <property type="nucleotide sequence ID" value="XM_031718676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3F0"/>
    <dbReference type="FunCoup" id="A0A6P8J3F0">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="GeneID" id="116308288"/>
    <dbReference type="KEGG" id="aten:116308288"/>
    <dbReference type="InParanoid" id="A0A6P8J3F0"/>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000111">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000132">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031574536.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="52321" checksum="C143A4A48E2E3B40" modified="2020-12-02" version="1">MADKTLDQELFLGIDLGTTSVKVTLLDYVSKKVLMFLKEDTKAVIVSNQSISSQLSEQNVGLIFTALNRILTSISAELRCRVQKIGICGQMHGCVFWKKGHEKFNIEHFNESGECDFISHLITWEDQRCSTQFLNSLPKTENSLLLSTGFGCATIFWFARNNPSFLSTYEYAGTVQDLLVALLCGTSKPIMSTQNAFSWGYYNLKEKAWEKEMLENAGFPVHFLPTVREPGTVSGVLPRAYLGIPAGAQISIALGDLQCSVLASLEQNTDAVLNIGTSSQIAVIVPSQGLCSYNNCILPSIQFWPFFDAAVVAVAASLTGGNALATFVATLQDWMKELGMPAILSKQELYAKLLKWGEGKTDTSLNIRPTLWGERHQTNLTGNVSCMSETNISLGDITASLCNGVINNLQTLMPRDWLISCGVKRIVGTGNALARNAILQKQTEKVWGLPLVIKEDSDASHGAALALFQSKLIQSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3K3</accession>
    <name>A0A6P8J3K3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nesprin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574227.1">
        <property type="nucleotide sequence ID" value="XM_031718367.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116308019"/>
    <dbReference type="InParanoid" id="A0A6P8J3K3"/>
    <dbReference type="OrthoDB" id="5963488at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21188">
        <property type="entry name" value="CH_PLEC-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000001">
        <property type="entry name" value="Microtubule-actin cross-linking factor 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000551">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000048">
        <property type="entry name" value="Short stop, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="76"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="88"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="72"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="37"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="156"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="12692"/>
            <end position="12727"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="11">
        <location>
            <begin position="12769"/>
            <end position="12841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2618"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2808"/>
            <end position="2899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2937"/>
            <end position="2980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2994"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3115"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3217"/>
            <end position="3295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="10145"/>
            <end position="10168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="10715"/>
            <end position="10737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12554"/>
            <end position="12640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12861"/>
            <end position="13081"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1823"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
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        </source>
    </evidence>
    <sequence length="340" mass="38372" checksum="95DEF390B46BCCF2" modified="2020-12-02" version="1">MPSVMIHNSTSSHNLTPTTEDFVQPKNGFNITIMVMQVLVIIVALLGNILICSAILIHERLRTHFTNYFIFSLSLSDIITAIIVMPMDVDQVLKNYKWTYGEAMCNIFTVAYLIAAPLSMLNLLAVSIDRYNAIANPLHYSNIMTPKVIVASIFSLWTYAILFTVIAMAGWPMYPSSVLYGTCHFNIKPAYSVVSSVINFVIPTIVMCVLYFKIYKVAHAHARRIGRHENISHSAVEYNSGTNGGGTSERRSMSKNIKAAKTIAILVSAFLFCWMPYTLVSSASILCGRKCYDNTPEEVITLTLLLAYMNSALNPFLYAFHNRDFRESFRRLLKLQFHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6U6</accession>
    <name>A0A6P8J6U6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Octopamine receptor beta-2R-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17 18 19 20 21 22 23" type="primary">LOC116309108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575522.1">
        <property type="nucleotide sequence ID" value="XM_031719662.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575523.1">
        <property type="nucleotide sequence ID" value="XM_031719663.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575524.1">
        <property type="nucleotide sequence ID" value="XM_031719664.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575525.1">
        <property type="nucleotide sequence ID" value="XM_031719665.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575526.1">
        <property type="nucleotide sequence ID" value="XM_031719666.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575527.1">
        <property type="nucleotide sequence ID" value="XM_031719667.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575528.1">
        <property type="nucleotide sequence ID" value="XM_031719668.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575529.1">
        <property type="nucleotide sequence ID" value="XM_031719669.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575530.1">
        <property type="nucleotide sequence ID" value="XM_031719670.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575532.1">
        <property type="nucleotide sequence ID" value="XM_031719672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6U6"/>
    <dbReference type="GeneID" id="116309108"/>
    <dbReference type="KEGG" id="aten:116309108"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="54"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031575522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031575523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031575524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031575525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031575526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031575527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031575528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031575529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031575530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031575532.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39311" checksum="E7210D3FBC20E39F" modified="2020-12-02" version="1">MMDFEDVTSKTMNRSNENLTTTSHGQGSGVLLNEQELKVFQATMSILCVLIVATNVLVCLLVYINKNIRSFTNGFVVSLAISDIMMGAIFFPVHLAVPDFSGIGYMTAISLLLGVSNVCCVTYDRYLSISSPLTYTMDIQQLFKRMIIACWSVPILFSLIPVIWDNNSYLIAHKVYIFILEIGGVIIPYAFVFAVYFYIFKQVQKCTNRLQTELSDQQTVQTKKKRLFFELKVARVFITIASVFLLCWAPLLYITTAVTLGRSDLVPEVLTVIAFYMLALESLINPLIYCFLKPDIQSAIRRTIRKTWRRDVTIRFHSKAAESAGIIIGTSNTNLRNCHNSNEHISAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J842</accession>
    <name>A0A6P8J842_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NACHT, LRR and PYD domains-containing protein 4E-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573958.1">
        <property type="nucleotide sequence ID" value="XM_031718098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307791"/>
    <dbReference type="KEGG" id="aten:116307791"/>
    <dbReference type="InParanoid" id="A0A6P8J842"/>
    <dbReference type="OrthoDB" id="5951217at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573958.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="69560" checksum="F649784EC6ED5E39" modified="2020-12-02" version="1">MSSQRKMSRPKNQELQSTTERDHAEDSEMLKEAIKANTENQTKIMAAHDIPSAKTDDIFTNLTVREQVEKNENLISFCHIPLSSFLLCWCLEWRISRSGITENLPAKITDLYNEVAKVLIEKLHANLKYSEMSEYAKKIAEDTLDKLAKLGANLLKESRYIFDEEDMKKLDLTHDEIKNLKVSGILHCVPGIRITAFXTKEEFSFTHLTLQEYLSASFFEKNNEIPEGMSEQTLVFMCGLLSKKKDGEQLMNKLIQQISSKYNVNKLLILQCLYEYGEQELTTITIHELYNKYCDSDGFIGFDRVTDADMKYVSYLLDIIRSLKEQHPQSSSDYTLSIHKSPALTLFGVGVVCRSLVCNSFITKLELYHCSLDDKCVEKITNSLVNTGITYLHLERNDITDEGVKSICNVLTQTKITYLDLVWSKVTDEGVKSICRVLTQTKITHLNLNRNKITHEGAESICSVLTDTKITYLNLEWNNIKDEGVRSVCSVLTQTKITHLNLGNNNITDEGAESICSVLTQTKXTHLNLGKNNITDEGAESICSVLTQTKITRLDLLGNNITDEGAESICSVIIQDDCHVKWLSLSGNKKITAECKERVKQLVEEHKPGVELDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JC81</accession>
    <name>A0A6P8JC81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308870</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575238.1">
        <property type="nucleotide sequence ID" value="XM_031719378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308870"/>
    <dbReference type="KEGG" id="aten:116308870"/>
    <dbReference type="InParanoid" id="A0A6P8JC81"/>
    <dbReference type="OrthoDB" id="5956805at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575238.1"/>
        </source>
    </evidence>
    <sequence length="1490" mass="168320" checksum="5B1105CF4725EB97" modified="2020-12-02" version="1">MMIYSFDIHKEFCCLSVRQTVEPCPAKSKMLLAIFIYLALSSNLFYEGHLLDNKTNGPNNVVYVSKARGQANSDSCGSESMPCKSLQIGVDKLAWGGRLFVDGEHTAVDPYKCESSAEKLVSTKSIFIQSYTTTAHISCIKGFFVTADGPNADKNVTITGVQLSNTLLFLKDISAVIRDCIFTASAPAITIKISNDSSLKLYSLDIQNAVFTENLGCIQVGVKKGRTCNSIIMNLRDTIFQNNTTPVKSGMDASGLISVNCSFAREMLFFSSWKNVKILKNRNNKEIRKNDRDFKNKELSGNGTSNVFVVDGCDGNLTFSEVASMNNQNSLRFLEAKSDSISISIQNSSYHEHHINEPGGVMRVKKNSCTKGDVIVSITDSIFHNNSGSLGGILQVDGKKEQSVKLNMNNVTLLQCYGSVNGCAVSVGTVKRIFALFDGLEVEECHDPSQLCMKQRCKRFPAFCLQASETAKITIKNSRFTRNKDQALLIQHTSGGQYNENILDVQISNSSFIKNSFSAGTKPTVELCVSLPDEMQKSILNISKSLFLRNTGVTIMTHKLVEVYVRNSTCEATMGVCLFIQCSTKIMMNSTLYIENCRFNENKYNVHFKNAKPSFIEISIKNTTFHKNHYQTYGIVIQVGRSGMKNTLESGRLLMDHVYFTSNYVSRAHGNILGVVSTPSKRNFTIVVRNSVFKNNRHIFRQNNTAFINLFYFYIPPALPDIEDINMKASPSPNESCPKYHYRSTIIFDNVTFLNNTAVTSTLFVNSGIVSFHNCLFEENFSSQPEIGGHVYVEKGATTARFYHTRFIQTKKNPRRLKSLVPLSPLLFVGAQGPLIMKNTSFKFDLYTPVTVPMFDLLRGHDVDMDNETTFVCPVGSYLKLFNATFVLRPDLNEANCKLTIIQLRFSCQRCPFNKYTLMSGSYRGKQKKNDVKCLDCPFGAQCTTSNIQSRPNFWGYKTQENPPQLKFEKCPEGYCEQPERSYNLSTYNKCAGHRGGTMCGACKTGYTENMFNHKCCPVHKCRDYWFWVVAAVHSVIIAIFVLCQPSLILFLTKKALWFREKKHTIPNTRVDHMEKTSNHDGHAYFKIIFYFYQVAELLMLETCSEILPNLPLLPSIISFYNFQVELADSSFGCPFPGLTAVTKELFLCSQVFGVMIVIVLFYLLHWLFSLMRKSPSPHFAHYLAAIVEVLLLGYERLGHTSFMLFNCVPLDMLGKIEWRLVIDGNITCWVHWWQYVMIAYNIVFVLPFLLVLFVGTSKLKRHQISALQFVAACFVPLPFLMYWLLRRCLRCDKDVLEDPNHLDQERQNALLEVLQGPFRPPDNQSKGALYWESIMIGRRLVMLCLFSFIAMLLPRLLCMTLVCMLILIHNVIVMPYKDQKANIFAVVFLAIHVAMATINLSESVLITAGVTFEGPLKTQINGFHMFEIFLLSVLPCAFALLVAAFLLSQTVRLLLIVSRYCLKYSEASSRRLSYQPLLNPGEDMPTYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JD74</accession>
    <name>A0A6P8JD74_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574465.1">
        <property type="nucleotide sequence ID" value="XM_031718605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JD74"/>
    <dbReference type="GeneID" id="116308226"/>
    <dbReference type="KEGG" id="aten:116308226"/>
    <dbReference type="InParanoid" id="A0A6P8JD74"/>
    <dbReference type="OrthoDB" id="5949069at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574465.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18642" checksum="72E60BD986142758" modified="2020-12-02" version="1">MKIVLFADFIATNHGLNQAQYVLKQLCDQGHHISLFECSDVSVPILIYEEPSTAIRGVYEDPLVLLERKVLQADAILLVTDRHTYETPASLVTVKKHFRGGNYVWRPYGINCILIGGSVHSRKVAMVLHSLLEGSDYMSGCLPRRCSWTKLYAIDYSMETPGPCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JDM6</accession>
    <name>A0A6P8JDM6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116308324 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574575.1">
        <property type="nucleotide sequence ID" value="XM_031718715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308324"/>
    <dbReference type="KEGG" id="aten:116308324"/>
    <dbReference type="InParanoid" id="A0A6P8JDM6"/>
    <dbReference type="OrthoDB" id="5989020at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031574575.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32684" checksum="4C367CB1C8370EE3" modified="2020-12-02" version="1">MAESNTSRNRKRTYNKINDVQRSKLQEFYDDGMKTCASVNRDKIDKAAEETGLSIEQVKKWIGNARQKEKISTGSQPAPKPIKIPTGSRGSHSYNMFCAEYFKSDECRKMSLPEKNKEASKKWKEMTSAEKEKYKLNADSLKSPDVSELXEAQKSKLISVHRKNLLREIMFLEDMGCESSIVFKDTSGQVYNFGSSAGLSFLSLNPEINIKFRDHFVCSDERYTYKNVXELFNSKYSEAIHKPGSRVPYLHGGFTVKAFPLWHESAKSYNGKQRKNKVRDSSKGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JE68</accession>
    <name>A0A6P8JE68_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574745.1">
        <property type="nucleotide sequence ID" value="XM_031718885.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8JE68">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="GeneID" id="116308467"/>
    <dbReference type="KEGG" id="aten:116308467"/>
    <dbReference type="InParanoid" id="A0A6P8JE68"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574745.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43013" checksum="55D703668BD8B771" modified="2020-12-02" version="1">MADASALKKIACQAIDNHAQALRQINRKIWEKPELSNQEMFAHEVLTDFLESEGFQVTRKWTLETAFGGQSGGDSGPCIGVISEYDALPEVGHACGHNLIAESGIAAAIGIKAALETSGNQLGKVLVIGSPAEEQGGGKLLMLENGCFKDVDFCMMVHPTPSDSTMPLVLANRSFYVTYKGYAAHAAAFPWEGINALDAAVMAYNSVSALRQQMKPTWRVHGVILEGGVKPYIIPDRSRLHFVVRAPNVEDLNRLSEKVIYCFEGAASATGCSLEIKKSAGYLDLKSNITMASLYQKNTETLGIQFPSLAEQKAKVLGSTDXGNVSYVIPSIHPIYSIDSMAVNHSYAFTAAAGTDVAHDKTLIAAKAMAMTAVDLFCRQDIREQAKQEFNEIHCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYS9</accession>
    <name>A0A6P8GYS9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116286344</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031548678.1">
        <property type="nucleotide sequence ID" value="XM_031692818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286344"/>
    <dbReference type="KEGG" id="aten:116286344"/>
    <dbReference type="InParanoid" id="A0A6P8GYS9"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1150"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1212"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1242"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1281"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1315"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1357"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1395"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="460"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="923"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="956"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="1188"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1484"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1548"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1490"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1558"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031548678.1"/>
        </source>
    </evidence>
    <sequence length="1584" mass="174632" checksum="608990F5BC62B05A" modified="2020-12-02" version="1">MSTRDPKYTTLFEAAKNGDKNRMEQLLDEGVNVNSKDKDGFSALHYAALSFSDSAVRFLLTKKASTLSAEKELGRIPLHLACSKPPGNPATTEIVKALVRTSGKEARVMIDKNGETPLSMAISAGNLQAIRELFAAGQVEQQLKAIKPNGDSIMHLAARRRDTEIAKYLIQHGAEIDLQNNEGQTPMHISAAEGDEHMFKVLYTMKGKIDIPDHEDRTPLYLATQGGYTGIIEFLVDKAKADVQIRSKDGNTLLHLSCSNGHADSTILLIKKGVLPQMPNKEGSLCIHNAARNGHANVVKALLEKGVPVDIKNKNNLTALHEAVMNRRHAVVQLLLGFGANKESVGGRDCESPIHMAARVRNGERVADILIRSGANPDTRNEKNGERALHVAARNGNLKVVRLLLKEDVEVARRSANGETPLHQACANGHYEIAKKIVEKLFNDKSFAFARLVVNIPNDRGETALHHLAQRVRRKESVEDLINIATLLLDHGANMTMKTSAKKETPLHWIARSGNYDVLKAMLTSTKVPLHIIQSGINSKTDIGASPLMIASHHGNLEVVKVLLKHGARVDVFDETGSTALHHAATYGHEEVACILLDHKAFVNGRTKLGVTPLHLAAEKGCVGLVKILVSKYKAVVDPATMDKKTPLHMGAESGFADVCSLLLSLGADANSSDSKGMIPVHYAAVKDREEVVEIFYKNRPETMTQPNDDGLTVMLLASREGSINVIKKLVSLNFSSCSTEKAVLSRPLLMAARAGHTEVVEFLLRSGASATEEDKDGMSVMLLGAKFGQMKVVDMLWGKVAIDRPSSKTGLTPVHVASLYGQTEVLQELLSRSSASGSFVSAPPLEKDETIDHGFTPLHLASQNGDPALIRMLMNNPGVVIDAKTVGKKRTPLHYAAFEGHIEVVSTLISKTTAPIHMKDAEGQTPLHMAAGNGYKELVTLLIGQGSDINSQDEEGNTPLHLSAQSGFLAVTKLLTEYGASTVAQNKAGKSAICLAASKRCSDVLNFLLGQKLDHDQLIRDKAFLLDLVNCARKEDQKPLKAFVLSAPAPVHISSLLAHSFSNESRKNKEYQTVLREATMVCETMANNLITVSCADDSESVLNALDGQNTAFLDFLIACDQKECVSHAIVQQYVTDIWYGDLKLEDWKFLLLFVAALFFPPIWIYLSLPFKNRYQYIPIIKFICRLISHLYLLMLFILTTVMPWGFSYQNLLPNVFEWMLLVWVIGLLLSEITSTRERRGLGWIPSIVVVMTFVGVIIHLVAFAYESEHRKNLIFSRNQVLAFGMVMCVVQLLQFLSIHHLFGPWSVIIGHLVVDVLRFLVIMLLFVFGFALQLAAVFKPMEENESGYTLKSVDTGIVAIIELLFFALFGLTSQKDVKYTSGDFPEATIGIAKAVFGVYNVLCMIVLINLLIAMMSDTYQRIQERSDVEWKFGRAKLIRTMEVEVSQPSPINIFTYMVNLIRILFKVRCNCMRSNIIGMMHAEEEQRKAKQKKDRNRKSHRSPNGLLQLKLENSGVTENSELRIQSVVDWNSMIDKYLDITGEKTVDPTLSKKGRAKNSNGPSAAQATGQALQRINVVNALKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZU3</accession>
    <name>A0A6P8GZU3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC116286297</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548622.1">
        <property type="nucleotide sequence ID" value="XM_031692762.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031548625.1">
        <property type="nucleotide sequence ID" value="XM_031692765.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031548626.1">
        <property type="nucleotide sequence ID" value="XM_031692766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZU3"/>
    <dbReference type="GeneID" id="116286297"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="198"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="278"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="381"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031548622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031548625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031548626.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="68765" checksum="D63B88048A9B26BA" modified="2020-12-02" version="1">MEGFDSKDNISYSTPKKSAPKNTINFNDSGIDGRSSDDSAMTDQLEMSGIADSKKALKIDDDDSPLPTRRIKTQVFVDIPEMSKFGEIWRRHNFNIVTIIITNILLVYSIIAICISGFKKVQVLFGLTMVLWFCLIYMFIREHWGDAIYRACIKPCVAVINSQWKWLKWLCILVILALIGVFLGLDTAKEPERFISVAGLFVNISICWLFSARRSKIKWRPVLWGLGLQFIFGLLILRTPQGFATFKFLGQTVQSFLDFTDVGAKFVFGDDFMKHFFAFKVLPVIVFFSSFISVCYYIGIMQVVIKKVAWLMQVTMATSAVESLNAAGNIFVGQTEAPLLVRPFLSHVTKSELHAIMTGGFATIAGGVLAAYIEFGVSASHLLSASVMSAPAALAISKLLYPETDKPETLDEDIHLPSSGERNVIEAAAKGASTAIALVANIAANLIAFLAFLAFFNAILSWLGSMVGHPEISFEYICSYLLRPVAFLMGVQWKDCDVVAELLGIKTFLNEFVAYIRLSGFITNRRKEIGDARTISIRSEIIATYALCGFSNLGSVGVQLGGLGPMAPHRISEMSKLAVRALFAGTIACFMTACVAGILYDESMYEGRSLLAAVNTTVLNTTVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H048</accession>
    <name>A0A6P8H048_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tctex1 domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548756.1">
        <property type="nucleotide sequence ID" value="XM_031692896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H048"/>
    <dbReference type="FunCoup" id="A0A6P8H048">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="GeneID" id="116286386"/>
    <dbReference type="KEGG" id="aten:116286386"/>
    <dbReference type="InParanoid" id="A0A6P8H048"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21459">
        <property type="entry name" value="DLC-like_TCTEX1D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000003">
        <property type="entry name" value="tctex1 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031548756.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14021" checksum="5878CAAFB35D49C2" modified="2020-12-02" version="1">MSEDLANSYAIRPNFKQKFRPAAVKTLIHDVLNEEIGNKKYDPEDSKDWPKLVSDALLVKLKELELDRYKFVVQVVIGEQRGEGVNVGCRCLWDSDTDNFAQDLLMTDTFFCVAAVYGVFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1K1</accession>
    <name>A0A6P8H1K1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116287722</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116287722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550269.1">
        <property type="nucleotide sequence ID" value="XM_031694409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287722"/>
    <dbReference type="KEGG" id="aten:116287722"/>
    <dbReference type="InParanoid" id="A0A6P8H1K1"/>
    <dbReference type="OrthoDB" id="5988723at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031550269.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="56551" checksum="C4ED5D81C22FD343" modified="2020-12-02" version="1">MYYLHLGDAVVKAYCYMDEMCGSKGWTMIMKIDGTKTTFHYASPYWTNKATYNIAGASGGXDDQETKLETYSHLSFNLLCLGFTSGNETNWMPLSYPANSLHSLIADGVYRNTSNGREVWKGLIQGSSLQNECHKEGFNVRFRFVNMARIGILGSSKKGCENPESRIGFGTGGNECGQDDWNTAGNEARCGSDNGDQSITGIGYIFARTEMKIDNQTSVPTVDPNRDADRSFGSLLNPAKSCLDIQQDMGRNATSGVYYLFLNGKTVMTYCHMEAICGKTGWTMIMKIDGHKTTFRYTSSYWTDTSTYNTALASGGLDNQETKLETYSEFPFETLCLGMRTNNATNWMSLTHPAASLYSLIANDTEILTNQGIKAWQTLIPGSSLQTKCIKEGFNVDGRRTSARIGIIGNQQKIVIRLIRGLDLGPPAVAVAKTIPTLLGMKRAVNRITEIRASKDLVIFSLVKSKTFFCNVSNICLEIKFDIKPREHVKILIVLVYPLFYRTYSKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H343</accession>
    <name>A0A6P8H343_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin p58/p45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549866.1">
        <property type="nucleotide sequence ID" value="XM_031694006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H343"/>
    <dbReference type="FunCoup" id="A0A6P8H343">
        <property type="interactions" value="1872"/>
    </dbReference>
    <dbReference type="GeneID" id="116287336"/>
    <dbReference type="KEGG" id="aten:116287336"/>
    <dbReference type="InParanoid" id="A0A6P8H343"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15967">
        <property type="entry name" value="Nucleoporin_FG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549866.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="58155" checksum="6CC7517467DCE6A8" modified="2020-12-02" version="1">MAAAVFGKTGATSGFSFGGVAATPQRSTATSTSGLFGGTLGASTPVGSISFGTTTTASGGLSLGGLSAAKPTTFSGFGQPAASTAASTGGFGFGQSSAISAAPTSNVLSLSGLQTVNPGTSLFSSSQPKTTGGFSLLGTTTSTSAPSKGLGAFGSTNTTSTTGGLFGNLASANAPKSTAGLVSTGVTGLGGTGTSSTVSLSGTATGIAGKQSEIQNLKDNQVPEPLVKIVEEIKKYVKQQKEHRDEISRFSASSIQKVQEETMSLRQSLAVVSNSIQRDACAVENLKMDVAQELKNAEIAQHTSEIPPALQHENTAPQEYFQRLVESFEERMQVYRKQIEIMESHLATLSQGQTLTPQDLSNVMHKVHETFIALAAQLHSIHEAVKLQKEHYLNYRKAYFKDSTDVFTRRRINARPNVSVPIGPSPFNSISNSTSRNTSNSSVNLPTTSKFGTTGGTTIGSSFGSSFGTGLSSGTSSFGTGGSLGSTSTGLGSSLGFKGFGTHAVGTSTGFGAGTQVSKPNTGFGFGTPTNTSLGSSFGTPATSASAFGTKFELQKPPTGNKRGKKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3P0</accession>
    <name>A0A6P8H3P0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate cyclase type 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550989.1">
        <property type="nucleotide sequence ID" value="XM_031695129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3P0"/>
    <dbReference type="GeneID" id="116288357"/>
    <dbReference type="KEGG" id="aten:116288357"/>
    <dbReference type="InParanoid" id="A0A6P8H3P0"/>
    <dbReference type="OrthoDB" id="10071600at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF16">
        <property type="entry name" value="ADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Adenylate cyclase N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550989.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36661" checksum="5420926C83C9FD80" modified="2020-12-02" version="1">MTTHAVGNTTTRKTSTPSKRAWEEEEAQTTFSRPNSSQSNLNKNLKEQNNAIATKRKESSGVKSMDSGVHGGEVRLKSVELGVEDSNIQSVNMAKGDRSTAAADNTNGELTVSVKNGSKLDKDTEKANNNEDEGEDADDSFVGHWKLFTRVLKSKRFESEKLESLYQRYIFRLNQKFASWLVFILIVLCIALVVFQFSLENEGDNIEGFIMIAFLVVYLVLAVIVNRSGSSDKQMSDSSQKQLRWVSYALLTLSCGIVLVSVLCPVGSNDSRKYNSPTDGVWVTIFFIYMTYTMLPVRMRIAVFGGCLLLTIHLVASAAQNSDNPNLPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H636</accession>
    <name>A0A6P8H636_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116288244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116288244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550873.1">
        <property type="nucleotide sequence ID" value="XM_031695013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H636"/>
    <dbReference type="GeneID" id="116288244"/>
    <dbReference type="KEGG" id="aten:116288244"/>
    <dbReference type="InParanoid" id="A0A6P8H636"/>
    <dbReference type="OrthoDB" id="5979096at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031550873.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19957" checksum="7BE20468CBE0E1E2" modified="2020-12-02" version="1">MNPSSGIYHLEKASRALNLLILVNTKSKNTHLEGKSKDRDLYKNMQVTIYTVQDPTVDFKYLKENINDVPHKMAIEQLFMTSPSSPSQSQESAMDGENLKPEEIIMKELKVTVEDRIRIEKDTRGQSESLRWYRERKGRITASIAKSCCSKGNPAATVKNILTVGKPGRGPNSPHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6Z7</accession>
    <name>A0A6P8H6Z7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Follistatin-related protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116289402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552169.1">
        <property type="nucleotide sequence ID" value="XM_031696309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6Z7"/>
    <dbReference type="FunCoup" id="A0A6P8H6Z7">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="GeneID" id="116289402"/>
    <dbReference type="KEGG" id="aten:116289402"/>
    <dbReference type="InParanoid" id="A0A6P8H6Z7"/>
    <dbReference type="OrthoDB" id="5952960at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030510">
        <property type="term" value="P:regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF81">
        <property type="entry name" value="KAZAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028264817" evidence="5">
        <location>
            <begin position="24"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552169.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="76288" checksum="8CDA0AFD2B9B50DF" modified="2020-12-02" version="1">MTREAGILVVLLVAFLASEQVYGLRVRAKLKEEKKKLQNYECSKVCPSGRRCALEGNKEVCVCLSVCPSRHKPVCGSDGKRYENHCELHRTACVTNTKIGIDWSNECINKGISELCSHERLVTLMEKILAHFRNELQTEAPPESLIHHLFRRRDKNDDNKIDQGELTSLLADYTKYEDMYATLAVCSVADWIHADDKNEDHFLEVEEFYSQYVKSKHEKEQSTQESARTDRPTVTVHEHQSSEYPTPLIEVFTEKLREPMAADHFTEPRDTDSTTGSPTVSAHHRNLFFAFGSEGIHVINPATLSLVRHIRAVDVVNGSLSPICTGSPEQPCTWGGAVNAGNQLIYAADALGGRLIVIDIATFSVIEEIAVRGYPYNPQYVAALDEVWFTNWAESIQVLTEEEEDNGTVNVVTMATKKISHSVTPVPLSESQAPIYGLHVVDSCHLRDEENFGYVTHLNETGFHELSLKDKEFTRFVNLSSHNCHGTYAFALSSSTGHAVVHCFTAKDGGQRAELVVDLKTEEVVAMTSVNIGIPHISPDGRFIVTFNDYTLSNLYFAYDGTIQIGEPMKSSLRLSDVAFLAKNDGYDFYVTSKDSSTAILLHTSPAGMQTLNVFTNCGMPQKAKDWLHTRRSIVTGCEAHDRYLATPATAEDAVVIIDGQQQSVSGRVEHVKGVVNLVWVGGEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7V0</accession>
    <name>A0A6P8H7V0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116288852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031551561.1">
        <property type="nucleotide sequence ID" value="XM_031695701.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H7V0">
        <property type="interactions" value="1876"/>
    </dbReference>
    <dbReference type="GeneID" id="116288852"/>
    <dbReference type="KEGG" id="aten:116288852"/>
    <dbReference type="InParanoid" id="A0A6P8H7V0"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000023">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18100">
        <property type="entry name" value="PDE4_UCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0114">cAMP</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="411"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="738"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="487"/>
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        </location>
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        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="527"/>
        </location>
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            <label>2</label>
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        <ligand>
            <name>AMP</name>
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            <position position="645"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>AMP</name>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551561.1"/>
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    </evidence>
    <sequence length="823" mass="92756" checksum="1B5678E4F1C404D2" modified="2020-12-02" version="1">MHSHLMDVYLYVLDSTRLILESFDISLVLCFLLIIGVIGAFLRKISSSSKHPCTGSTSKTSKSNLKSSPQQNKRQGSVTFAEGTKFDELAHQDSNLAALKKMSSTGSRKVQRSPLKISLTNDDGEDVGSTGFPRKRERSKYSPSGEESSEKPEPDKLAIPVPPQRRESFLYKSDSEFELASKCVTSRHHSFSEGTRVEELVTPFAQILSSLRNVRNTFVTLTNAXKEKRGGSVGPQLNKTNLSDLQNSIGSLQIPRDENYQIVANNTLEELDWILYQLETLQTHSSVSEMASNKFKRLLNRELKDFSDANQSGNQVSAWVYNTFTDDLVNRRCSPTDPAPPSPKAAYSPILFKNTTLANPDKQLEIQADPNQSKPRKDCIRARSRSMVNGVRKLTRLHSFSGTVPRIFYLQGSDKENCNQKILEGINRWDFDAFSLDEATTGHPMLAVTYTILQARDLLKIFKIKPTTFINYMTLVESHYLKDVPFHNCIHAADVTQTTHVLLSAQAFDSVFTDLEILSAIIASAVHDVDHPGVNNHFLVATNSEMALMYNDESVLENHHLAVAFQLLQHEDCDIFENLSKSERQSARRMIIEMVLATDNAKHMSLLASLKTMVETKKVAGTGVLCLDTYTDRMQVLKSLVHCADLSNPTKPLHIYRKWVDRLMEEFFRQGDKERAIEGMDISPMMDRHNASIEKSQVVFIDFVAQPLWETWGELVQPDAQELLDTIEDNRHWYNCQIPKNEQDKNNPASMKRVSWQGTRKDAIDQSEPETSEENSTNGNTRNNNFKDLLHTKCESSGRSCEADDEYDGDSSFDCSAADGNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAK4</accession>
    <name>A0A6P8HAK4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase-activating protein 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549702.1">
        <property type="nucleotide sequence ID" value="XM_031693842.1"/>
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        <property type="interactions" value="528"/>
    </dbReference>
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    <dbReference type="KEGG" id="aten:116287205"/>
    <dbReference type="InParanoid" id="A0A6P8HAK4"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17115">
        <property type="entry name" value="RA_RHG20"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rho GTPase activation protein"/>
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    </dbReference>
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        <property type="entry name" value="ARHGAP20_RA"/>
    </dbReference>
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        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="167"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="432"/>
            <end position="457"/>
        </location>
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            <begin position="472"/>
            <end position="496"/>
        </location>
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    </feature>
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            <begin position="652"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
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            <end position="616"/>
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            <end position="673"/>
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            <begin position="674"/>
            <end position="687"/>
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    </feature>
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        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
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        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
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        <location>
            <begin position="866"/>
            <end position="914"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549702.1"/>
        </source>
    </evidence>
    <sequence length="986" mass="109137" checksum="77300D2E25FFDC05" modified="2020-12-02" version="1">MESADSFGASKSFAISNFDDTSAVVKMSLEQFEIQTDDASEYHLWVLSGKENCAYPLLGHEFPFAIKMNHIREASTSDEYGGNIFDFDQQLPSMDPLSPSTQCQFILTKSKKTSKVSSVEGQQSSRKWKNPIKKSPIINWAMHKKTTGSKNQNSDSQSPPAGKLFELPLDVLCTEEEPVPKPIQDILRHMFRYGPGVNGIFRKSASAKRAKEIKLDLDSGKEVLFEEVSVVITASILKEFLRRLPDSILDSDDYEELIATNNIEDRDERIKQIKWFLQNLNVYNYEILKRFMCVLYHIAENSNINSMNAYNLAVCVAPSMLWPPKGSNIAATEQSSDVPPFVQFLIENCIEIFGEDVVTILGDRSEIVLNQEPLEPENGIEIQTFNRQSSTDDGLESPEPLSPRNERSSLNLSDSNLYNADARSKNLLSAGIPERNSVSTPSSPCVSPNSSPKLRRPNIEMSNQLRDAFFEPNSXNSVLDGRRSSEPSELNSESTKMKIKGYRKMPRSRRQLSSTTTSAELIEHKQPKTTPSGKKLETAVLRRAHSPLTVQALPVDANIAKPIPKYCPSSSVITTANRIPPVKYAVRTQALASNGSEDRGASPDISSMRSPSPTLTPDQVFQAVDRRRQPAAPSYHQHMLRKIGSKPAFFQGRSESSETLANEKNAVKNISTEGNDRYDDECKTDRSKFKHFTRSSSIPSDRKCRPEPLDLSRSEPCTPNSPLSPVKKEEQTWPDHRDDTSTSSGGSSTRRLEHSPFGLNLHHKRSSSDNIKKIPKVQTQIKPQIKTVNSRQLLLNGGNTHFPPSEFFPHEATQAKTQWGSENPSHGQVGQISPGATVSVPLYVFTPSEKLPVVALHTPELEGNPSGMATLSTSASSTGTSPSLSGRKSSHTSSSSSVSSSDDRSSVGADVAVSETKTNITQIRDLKELLSVQAQTNGLKISQETAEEIAKVKEIRASSDSRLHSGYTSPSHDDMEKMLFTEESYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBA3</accession>
    <name>A0A6P8HBA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deleted in azoospermia protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552891.1">
        <property type="nucleotide sequence ID" value="XM_031697031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBA3"/>
    <dbReference type="FunCoup" id="A0A6P8HBA3">
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    </dbReference>
    <dbReference type="GeneID" id="116290053"/>
    <dbReference type="KEGG" id="aten:116290053"/>
    <dbReference type="InParanoid" id="A0A6P8HBA3"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF57">
        <property type="entry name" value="PROTEIN BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552891.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20949" checksum="90E97A09AE3E7600" modified="2020-12-02" version="1">MLKDLGSTMQSRSWQSASSNAYTSINDNSALVKKMPNRVFVGGLPFDTTATELIEFFTNFGAVLDGKIIYDYENVSRGYGFITFYREEDVEKVLKLGVIFFKEKRLKIAEAFRRLKKRYPQRPAFPSPVQMTFPAKPQYLQSEQVTQTPIKCYTQPQVYHENRPTYGGLWRCAVVEQKLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBE2</accession>
    <name>A0A6P8HBE2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein UXT homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UXT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552443.1">
        <property type="nucleotide sequence ID" value="XM_031696583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBE2"/>
    <dbReference type="FunCoup" id="A0A6P8HBE2">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="GeneID" id="116289636"/>
    <dbReference type="KEGG" id="aten:116289636"/>
    <dbReference type="InParanoid" id="A0A6P8HBE2"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003994">
        <property type="entry name" value="UXT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF9">
        <property type="entry name" value="PROTEIN UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01502">
        <property type="entry name" value="UXTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552443.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18002" checksum="C6BB06480AEBA177" modified="2020-12-02" version="1">MADASEEKSDIQEKVLKYEEFIDKRLRKDLEAVYKAQEDVYTKINEYTQLKTTIKQLQNSHPKGEKLKTTVDLGTNFYCEAEVADTSMIYVAVGFGFYVQFTFDEALNFIEKKCGILNSTAKRLCKDAAKIKAHMKVVLGGLQELQNISFGKDDETGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBQ8</accession>
    <name>A0A6P8HBQ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LanC-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549930.1">
        <property type="nucleotide sequence ID" value="XM_031694070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBQ8"/>
    <dbReference type="FunCoup" id="A0A6P8HBQ8">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="GeneID" id="116287395"/>
    <dbReference type="KEGG" id="aten:116287395"/>
    <dbReference type="InParanoid" id="A0A6P8HBQ8"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000012">
        <property type="entry name" value="LanC-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549930.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47180" checksum="5102B1371752823A" modified="2020-12-02" version="1">MCYFCAMHSSRYFINRYADFTGSIGDCSYVRELISRLLSQIEKKCPPTSHENMDGGLYVGLAGIGYALYHVADSGLFPEHRQQLLIKALQYLKIPQAQANRVSPHSNGGIGAAFLLGHAGVYAVSALVYNALGLHEEKEQSYKKFLEMHNICKPVNFFPHGSDELLIGRSGYLCTVLELNRKLKPKIVPNEVTFPLIDSMLQSGIQYVRHHKTNSPLMYSYYNTEYLGAAHGLCSILQMILSFPEYFKDRKDIKSLMVNSVAFVLSQEQPNGNYPAAVDEPRDSSNELVHWCHGAPGVIYLLAKAYLTWKDEKYLKAALRCGEVVWEKGLLRKGPGICHGVAGNGYVFLLLYRLTRDQKHLYRAYKFADFMQTEEFQKGARTPDCPYSLYEGLAGTVCFYTDLLLPDKAAFPFFDVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBZ7</accession>
    <name>A0A6P8HBZ7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tartrate-resistant acid phosphatase type 5</fullName>
            <ecNumber evidence="2 6">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2 6"/>
    <dbReference type="RefSeq" id="XP_031550025.1">
        <property type="nucleotide sequence ID" value="XM_031694165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBZ7"/>
    <dbReference type="FunCoup" id="A0A6P8HBZ7">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="A0A6P8HBZ7">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="116287485"/>
    <dbReference type="KEGG" id="aten:116287485"/>
    <dbReference type="InParanoid" id="A0A6P8HBZ7"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000062">
        <property type="entry name" value="Tartrate-resistant acid phosphatase type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027948060" description="Tartrate-resistant acid phosphatase type 5" evidence="10">
        <location>
            <begin position="22"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550025.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38211" checksum="517609DB95D9DB30" modified="2020-12-02" version="1">MSTIKSTMFFWFWGFIALVHGFSTSVKRDQLNFIVLGDWGGLNFFPYKTPIESAVAKQMSKTSEQLGAQFIVALGDNFYFSGVKNVNDKRFEETFENVFSSKSLQIPWYFCAGNHDHYGNASAQIAYSQKSNRWNFPYYYYTKDWTIPGTDKKLQLVMIDTVLLCGNTVHDFLGGNNAQGPDSIDDAEVQWSWLEKTLKSSQAQYLLVGGHFPVWSIAEHGPTQCLVERLKPLLEKYDVTAYLSGHDHNLQHIKDPKSSVDYFVSGSGAYVANKTDHKDDIPALSLQFYWANPYSYGGFATIQASPSSMLLTFIDAEGRQLYTRALHSREYKHNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC78</accession>
    <name>A0A6P8HC78_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lithostathine-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550277.1">
        <property type="nucleotide sequence ID" value="XM_031694417.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287728"/>
    <dbReference type="KEGG" id="aten:116287728"/>
    <dbReference type="InParanoid" id="A0A6P8HC78"/>
    <dbReference type="OrthoDB" id="5976046at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027610259" evidence="2">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550277.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26203" checksum="E7DFE6998E56CB94" modified="2020-12-02" version="1">MGLFVVRVQFVVMLMAFRMLWKTSYASDCSFYTLHDIATNWRTARLQCQANGGDLLSMETVKEYQFINXTIQSQNKGXNEWHIGLTKTRTGSWKWISGYSLTIDKWQPNEPSGDSHGYCVIMAKNWPPGTHGLFNDLNCNIYRMFICEYKNDVNHTQGVLKFCPTVTTTQRPTVTRSRRTNIKTTMSNELTSLSMSHADPPATPEPLTEWTSRNASIHEQDEEDNHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCD6</accession>
    <name>A0A6P8HCD6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Octopamine receptor Oamb-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC116287784</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550341.1">
        <property type="nucleotide sequence ID" value="XM_031694481.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550342.1">
        <property type="nucleotide sequence ID" value="XM_031694482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCD6"/>
    <dbReference type="GeneID" id="116287784"/>
    <dbReference type="KEGG" id="aten:116287784"/>
    <dbReference type="OrthoDB" id="5956898at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="33"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031550341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550342.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41287" checksum="C6EEEA569E993FA5" modified="2020-12-02" version="1">MNFTKKCPNYLSNDSAMVLAVLNGVSAIFAVGGNTLILVAIYRKTYLQTVSNFFLGSLAAADLLVGLLMNPLNIVMNTLQAWVQFDGIWMKLQSFLWIQLTTATTFSLTAVTFDRFLAVMMALRYKETVTSFKCFLIVFFNWAFSIFFGSMTFWLPNEQMTSLWSACAFVTVVVPLTVISFCYVRMCKTAFLHTRRIASQNRLPTLQKQINHKRRQTKATWTAAVIIVVFVFLFLPSFIINCLQILNKDRCRMNYYQSIWAWVSFVSYISSSINPWIYAIRSDEYRLAFKSIFMLNTAGEPSRFGSIFDRSKVETTGGVIKRQGTPTQERHDTFHIENCQENEASPGNKYPYEVGARQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCV8</accession>
    <name>A0A6P8HCV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Epididymal sperm-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the seminal plasma protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550527.1">
        <property type="nucleotide sequence ID" value="XM_031694667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCV8"/>
    <dbReference type="GeneID" id="116287957"/>
    <dbReference type="KEGG" id="aten:116287957"/>
    <dbReference type="InParanoid" id="A0A6P8HCV8"/>
    <dbReference type="OrthoDB" id="5947142at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000003">
        <property type="entry name" value="binder of sperm protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000009">
        <property type="entry name" value="Epididymal sperm-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051666">
        <property type="entry name" value="SP_Capacitation_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE-II DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918">
        <property type="entry name" value="SEMINAL PLASMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028400901" evidence="7">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="248"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031550527.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33736" checksum="8F49CEAD6F831F7D" modified="2020-12-02" version="1">MAHWNFVLFALLQSVLVTSLVSGQMTTSGENCTFPFTYRDIVYNSCTTKNHNRPWCSTTANYDTDKKWGNCAGFAKSGVETTRGESCAFPFIYRGVVYNSCTTAVHFLPWCSTTVNYDKDKKWSNCAGFSSGVSTESGGFCVFPFTYKGQEYKSCITKGNKRPWCSTTANYDKDRKNDTCKGFFIDDSRTTSGEYCAFPFVYKGQHYNTWTLKNHDRFWCSTTTNYDEDKKWGNIPFGKGERIITLTTTGEYCVFPFVYEGRQYNNCTSKNHHRPWCSVTANYDKEKEWGDCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFT5</accession>
    <name>A0A6P8HFT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Mucin-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116288762</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551445.1">
        <property type="nucleotide sequence ID" value="XM_031695585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFT5"/>
    <dbReference type="GeneID" id="116288762"/>
    <dbReference type="KEGG" id="aten:116288762"/>
    <dbReference type="InParanoid" id="A0A6P8HFT5"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1163"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="15">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="14">
        <location>
            <begin position="182"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="16">
        <location>
            <begin position="319"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="676"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="935"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="975"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031551445.1"/>
        </source>
    </evidence>
    <sequence length="1234" mass="137901" checksum="5D592832557ACC86" modified="2020-12-02" version="1">MYTSSNKKVKSINVLNRATSEVHRLYISKAKLLYNHTSLNQFQASLVLVVTWHNLRHFNLNSETRNLYNTFQAVIITDGVYTFVMYNYPPDVILWSAPTTSAKWGLYTKGNSINDPLPVVGWSAGCRREEYFNVPRSGEVMIGNISKITGKTVFGNPKKRNEFKNYSHLSQGKWLFRLETSLVKLSKDKCKSWFKKEPDPRPVLEYLEPCPCTFFQAQWDERFDVQEGWRGKSEVCAYSTFTSIDGWQQKCCYSNDGRSNGALIVGHPGGGSALRKKYVKNVISDDDKFYDRCCVQTAMCHLYYQRRPSDNCKQYEPPEWSWMWGDPHFVTLDGKNYTFNGLGEYVMLDAKDGFFELQARTRLAKGGGTATVFCAAVAKERNTSKVEISLKREGNFTLFVDGETLDYYSLTNQSTSLNGSVVVLRPKDNSFRATFPSGISVTVTEVKGALSILLAMPKSFRNQTKGLLGTWNGDQTDDLTTPSGDVLPANASSKNIHFQFGQKWQVNESTSLFTYQFNENVSTFSNTSFVPMFIEDLIEEFYNESLKQQAQAACKGDINCLFDSASTKDVSVGISTKIVGSQLVYESNTLKNSPPKFDNTSSVLYLTVNFSKSVTFKAKDPDGDKIRFNITGPPDDATVWTNESSIILKWMVTTKSVKLEIIATDNKGATSVLRPVLHVCACYNGGDCLITNQEEEEDRNNSRFSIMSCQCPSGYTGRFCESDVDACEVNMNPCYPGVQCKDLPAPANVTGYECGPCPSGFSGQGDSCLDIDECDDFVSQRCSQICANTPGSFICGCNPGYVLNEGGRSCDDVNECHPASDCMQRCVNTPGSYTCTCDKYFTVDPTNPKRCIPESPCKDGNHQCQDICYVSNGTDHCTCHPGYELQHDNKSCTDIDECTTGKNRCNQECRNIIGWYDCKCRPGYRLDTDNVTCIDIDECLEWTFNCSANLRCRNTIGSYECECRIGLVWKGNECQEPEKPATTSPPSTPRPPSKRDIQNSVNVTIKGLDITEWHHKKDLKFKNAVAQEVTEFCSKSQSCFRPKTRVRRSTGVTFTTQEVHLLPGYPVQLSYSSIPDHVIAAVAFYVNFPPGAAIGVTDTVDKNILVDIVKGSLARIGRAINKTILSVSVYMDEKLTGQPTTKPYTPTNNEPTDTRDHKEKTGYVRYLIIGGSVVGTLLIFIIIVVIIRKSRESSPAAIKKQVEIEMKMQNEDYSIDNLGADILDTDKPAYQINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGK7</accession>
    <name>A0A6P8HGK7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116288978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551712.1">
        <property type="nucleotide sequence ID" value="XM_031695852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGK7"/>
    <dbReference type="FunCoup" id="A0A6P8HGK7">
        <property type="interactions" value="2449"/>
    </dbReference>
    <dbReference type="GeneID" id="116288978"/>
    <dbReference type="KEGG" id="aten:116288978"/>
    <dbReference type="InParanoid" id="A0A6P8HGK7"/>
    <dbReference type="OrthoDB" id="2286203at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036149">
        <property type="entry name" value="APC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13512">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13512:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58050">
        <property type="entry name" value="N-terminal coiled coil domain from apc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551712.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17548" checksum="737FD466FA02961F" modified="2020-12-02" version="1">MADDVASSLEYSLQACISLLGVDVLDKGKGQQCIDNKLGVEAAITSFLESAKLVEEDFIRKQAYVRVHHPQETLKQEISHLKTEIKQKEDILSKLSEKVDYWTKILDELQRKQKAEIEAMLTTGAMGKGSFTFKLSYKVGVMLSRTKSADALLSIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGQ1</accession>
    <name>A0A6P8HGQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Fibrillin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116292408</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555589.1">
        <property type="nucleotide sequence ID" value="XM_031699729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292408"/>
    <dbReference type="KEGG" id="aten:116292408"/>
    <dbReference type="InParanoid" id="A0A6P8HGQ1"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028139803" evidence="17">
        <location>
            <begin position="24"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="160"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="656"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="697"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="738"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1024"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031555589.1"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117925" checksum="462C1B99EE6E7F58" modified="2020-12-02" version="1">MNLFGKFGLQLVLATVFLCVVESLPRSGLARFRSRSFRSSSNVQCGGTIRGTSGEISSPNFPRNYPDEIECRWKIIGEIGSRITLTFRDFKVETSHECEYDSLEIYNGERKVDSKRIAKLCGATLPRVIVSEESSLFLRFHSDFSVNFEGFRLDFTQSGCSRRYTGLSGTXTSPNHPNVYPLSVDCTYTIEVPTGKRISLAFSHFEVEVEEDSSGCIYDYVQVFDGSSIADHSLGKFCGKRLPALVRSTSNFMTIKFVADQSISHSGFSARYQVETPGIFDPCRINNGGCSHMCTSRGQRRHCSCHPGYVLAFDEETCTDIDECQVNNGGCRSQCVNTPGSFHCVCEEGYTQSKDNKTCVNINECATKQHKCEQVCRDSEGSYYCECRQGYQLDTNGYSCIDINECKMXTSFHHCNQICINTPGSYYCKCRDGFILSANGRICRDQDECMMGGVQCDQRCINTAGSFXCACFPGFRPNTVMPNKCVDVDECQEGLPDCHTCVNSEGSFHCLCDKGYIEADNRTRCKDIDECMKNNGXCSQLCVNTAGGYHCKCEAGYNATDSESRKCTDINECASHDGKGDCDHMCTNTAGSFKCSCHAGYFLTEDGLTCQDIDECKVLNGGCKQKCVNFPGNFTCACHDGYLTIGKNGSDFICQDIDECSTGLHECDSGATCVNTVGNYTCICPAGYYANFHDCIDVDECKSGRNGCQQICNNTPGSFHCQCLSGYTLDANGKTCTDIDECSQGMCERECINIQGSYLCMCPDGYELAPDKRHCRDIDECSSNNGDCDQICVNTNGSHHCRCKSGYERLGDQKTCRDLDECSINTACCNQGCVNTEGGYNCTCSKGFTLTSRCTCTDIDECAVRNGNCQQICTNKPGNYGCSCSPGFLVDSLDPTRCQDIDECKTGNGGCQHNCTNTIGTYQCTCHPKFKLQADGKSCGHCPTCDDFESLLQTVQILKKQVASLEAWRQSIHRGCIDDNFDFHPEDSSWKITSCIICSCEKGKIMCEPIMGCKASDEITISTEKPQDVHSQPVTPTKVTTDDDDEPGSASTGTRANEEDPLFTINRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH03</accession>
    <name>A0A6P8HH03_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289091</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551840.1">
        <property type="nucleotide sequence ID" value="XM_031695980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289091"/>
    <dbReference type="KEGG" id="aten:116289091"/>
    <dbReference type="InParanoid" id="A0A6P8HH03"/>
    <dbReference type="OrthoDB" id="5946700at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031551840.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="38079" checksum="2D6B1F175200178E" modified="2020-12-02" version="1">MFEYFIHLMESYPAHQFRANWQNAELKKLIDNLPLGHVCCIHDYSENYSCQHQDQIQSLYYGEVQVSIHVTVMHRHAIREIDGEESTPDDPAVITEHLYVISPDTKHDSHSVHNCRDQISQYLKDIGCAVETXXEWTDGCAAQYKSRHCLGDLSMSVKDFGFSTIRNYFETSHAKGPQDGAGANLKHKXDMAVIRREVVIQNARDLFNFAENNLKEPSPSRYQSHNVRLKRRVFFYVESQSHDRSDRLFKEVKEIRSIHSVKSTEEELKISTRQLSCYCYHCLNGDYSDCLHKDYVPHWESKEMENEQHGRRVTRXIAQQETPEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH04</accession>
    <name>A0A6P8HH04_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116289135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551872.1">
        <property type="nucleotide sequence ID" value="XM_031696012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HH04"/>
    <dbReference type="FunCoup" id="A0A6P8HH04">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="GeneID" id="116289135"/>
    <dbReference type="KEGG" id="aten:116289135"/>
    <dbReference type="InParanoid" id="A0A6P8HH04"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027565944" evidence="2">
        <location>
            <begin position="28"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="42"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="198"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="347"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551872.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50340" checksum="E4696514756192CA" modified="2020-12-02" version="1">MKASSLVCMIVVSVLLILSLRIVRVKAAVEDIGEERFKAQRCQLPLGMEDGRITDYQITASSNFSLKSSAHRGRLGTKKGEKGYGAWSSKSSNSGWLQVDLGDVSMVTKVATQGRQDADQWIQMYRLMYSIDGIQWAECRDANSDREIFSGNSDRDAIATNILKPIIYARYVRFVVTSAHGHASMRVEVYGCRNVQSCSVPLGMEDKRIPDTAIKASNYIHSSYPRYGRLNLGYAWCTDSKGKYLQIDLGEVKTITKVATQGYQGGTSYVTAYQIEHSIDGIHWVFYYTPNMKKKSFPANNNYFDIHTNTLENHIIARYVRIWPQAYAVEHYCLRAEFYGCKEEGKCSMPLGVQDGRVNNDEMTASSAHSDDLAPYKGRINTEGCGWLANVQNKKQWLQIDLRTVKKVTAVVTQGEFDDYWVTAYKLNHSVDAVHWVTVKKNGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK05</accession>
    <name>A0A6P8HK05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein CDX-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555218.1">
        <property type="nucleotide sequence ID" value="XM_031699358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK05"/>
    <dbReference type="GeneID" id="116292109"/>
    <dbReference type="KEGG" id="aten:116292109"/>
    <dbReference type="InParanoid" id="A0A6P8HK05"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555218.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="33101" checksum="4C950412CC1C9920" modified="2020-12-02" version="1">MAEEGNMERIEIIEAASTLISLRRHFEERIRWQRSRTTLFTPTTQVFNPFNYGQMWPFYKPFPYDVTALSLMHHHPPFPFQISPYMVGPPRPWFPAPQVSFPSPLRNRESLADSLPSTPISSTPPRTTQIPVAMETGEGSLHDENGDSGEQDESTTATNDKYDQKRKRRNLTKRQQEILEKAYYTTKYPHIEERLRLGKATQLTEDRIQIWFQNRRAKDRRMTDSIKSPPRKPAELENNEIPNQEDEAVHVKVEGGEGEDDTQCTPGDDREYCGEPSPKRIKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKB3</accession>
    <name>A0A6P8HKB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall protein DAN4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556251.1">
        <property type="nucleotide sequence ID" value="XM_031700391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293008"/>
    <dbReference type="KEGG" id="aten:116293008"/>
    <dbReference type="InParanoid" id="A0A6P8HKB3"/>
    <dbReference type="OrthoDB" id="10517364at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028415059" evidence="3">
        <location>
            <begin position="23"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556251.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="34200" checksum="D586B79B3BD24005" modified="2020-12-02" version="1">MIVLCAWIQLCTLVVLCTLANGTANNSANTKAPTPTTNSTSPTLTTSNIIPTTTTPNATSSEVEKGNNATTSIMTGTTTTASNTPANTLATNXTVTIDTSTPSITGTNSTSTAAATTTPTTSAAASTTATSTTTSTTATSTAAANTSTPSTTTSTTATSSAAANADTTSTAAVTIAAKPSATTTSPTNTITTVVPETETSVKSTIPQSTGGINSTASISRHNTTTVTSNTISVSTPSKQTTTSSIGVSSSVVMPTVAPSWTNWTTEKNCAAKCCATGGTVTQYRACTKGSITLTSAVPCNGNLSQIVDCWGACDCSSGSMFIAERIVAVGCVVLGLVINLLYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL62</accession>
    <name>A0A6P8HL62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Telomere length and silencing protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116293798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557139.1">
        <property type="nucleotide sequence ID" value="XM_031701279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HL62"/>
    <dbReference type="FunCoup" id="A0A6P8HL62">
        <property type="interactions" value="2874"/>
    </dbReference>
    <dbReference type="GeneID" id="116293798"/>
    <dbReference type="KEGG" id="aten:116293798"/>
    <dbReference type="InParanoid" id="A0A6P8HL62"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031557139.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36512" checksum="18A5FE2CCD479EE4" modified="2020-12-02" version="1">MSRRNYRRKRVSEEEDYDEPDTTTELLEERKELQKFRKRPKGVSAIGLALGKELPPEESVVSDPFKLKTGGLVQMNDFIQDRDRDRDDEGTGMSVVIGANFAAETNRRDEDTLMLKYIEEEIARKKGASNNSEGGERSEKSKSKEDLLYTVPKNIDVRSKLMKSEEMLSNQMLSGIPEVDLGISAKIRNIEATEEAKMKLLEEQRSKKRREPTEMVPTNMASNFMLHSRFFDEQRSVEAESKKAARIKAKEEEEKNKPKGPTVPAVDSTLITGNDADPGAVAVSVPTDGKKKDTKKERSSDDFYYEKFRKRARDNWRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLF9</accession>
    <name>A0A6P8HLF9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 624-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553507.1">
        <property type="nucleotide sequence ID" value="XM_031697647.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HLF9">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="GeneID" id="116290576"/>
    <dbReference type="KEGG" id="aten:116290576"/>
    <dbReference type="InParanoid" id="A0A6P8HLF9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF22">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE PRDM6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="103"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553507.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="80544" checksum="0ED5E350751E26C8" modified="2020-12-02" version="1">MSSGPPGRIRVQVSTTANDNEDQATQLKFNFEDLLHVLYGKKQASTVDLLQLQKERKKEXTKTYCVVCHVDRPPNGCPFHEPSSTYTADRNNSLSYAIKSFPAEVQLCTSSIPGAIFGVCAKRVIPEGTWIGPYEGRRVSPEELSVSRNNPYVWEIXEDGQPSYYIDGSDESASSWMRFIRCARHKEEQNLYAFQYLGNIFYRSFKEIPKGTEMLVWYDDKYPQHLGIPTGLQEIEFISSSDLVGSSSGAKVSNTASKNEGDSRHKVDQEKDEVKEMDISRSLKDYNPRLAVHPAESRQRVMATPSPHRLRHSSYLTRISCAPHSLSSSPGFPTPEMSSISSPAIPYATVAPHYTLPNLPIVPPLQSNTPAGVYGVAYRHHMPVNISAGIPVSISGRGQLGITGTHLPRVHQEVLEEGPIITSSDSVVYNDRQYRPTSSISPTLGKMDRESYLQRKRAFYSSTTANPDASDEAGHPKIVMSKRKATEVTTIDSDSRQYPPLTKRKSPLSFINEEGSVENETGRSNRPRTPKERLTDDQGSERNRSTKSHRLHLSKEEHASQISRVTSAWPSDESQSQDEAAGESSDSNSTSSTKNETAGIDEISMWRCRQCQKTFTQRVMLQVHVCPQQPLKPYRCGQCELSFATATELRSHVETHASEKPFKCGFCSRSFAGATTLNNHIRTHMGKRPFSCEHCGKGFAQAGQLARHQRTPGECEPRTTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLW1</accession>
    <name>A0A6P8HLW1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Steroid 17-alpha-hydroxylase/17,20 lyase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553637.1">
        <property type="nucleotide sequence ID" value="XM_031697777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290675"/>
    <dbReference type="KEGG" id="aten:116290675"/>
    <dbReference type="InParanoid" id="A0A6P8HLW1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11027">
        <property type="entry name" value="CYP17A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000094">
        <property type="entry name" value="cytochrome P450 2J6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553637.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58650" checksum="0B7117FBCAE7B2AE" modified="2020-12-02" version="1">MGHLWTMLPSITLFTVFTVVAILVYYYFFKFVGRNLPPGPIPLPLIGNLHILGQDLQNSLKDLADKYGKVFRLYIGEKLVVVLSGDAIREALVRKPSDFAGRPSMYFYKIALRDDPPLVLIDYGDHWKIHRRLAHKTIKVYGTNRYEMIIQQEITELCTRLQLKESLGKPARIKIEIGLAIMNVICNQIFGSRFDVGDPEFLEMFQLQAELFRLSTVAARGLVDLFPFLRFVLPVSGDVRQLQITNDRWREILCKKYREHQQTFDKDNLRDYTDVILNARREAEEENSKELEYLQDKHLISSITTLFIAGSETAATTLTWAVLYLLHFPDIQRKIHAEIDTVIGRRGPVRLDTRKSLPYLEAFICETMRYTSILPLSVPHMTTVNTTIGGYDIPKGTTVIVNIWALHRDPSFWKDPERFHPERFLDADGTFVFPDGGYFLPFGAGPRACMGEVLARCELFLFLANLLQKFTFENPAGVAXPPLKHLPGGAVLQPAIEQVMVKTRPVKGYTSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMC4</accession>
    <name>A0A6P8HMC4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031553800.1">
        <property type="nucleotide sequence ID" value="XM_031697940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMC4"/>
    <dbReference type="FunCoup" id="A0A6P8HMC4">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="GeneID" id="116290832"/>
    <dbReference type="KEGG" id="aten:116290832"/>
    <dbReference type="InParanoid" id="A0A6P8HMC4"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000015">
        <property type="entry name" value="Phospholipase A(2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF51">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028514159" description="Phospholipase A2" evidence="8">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="46"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553800.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17674" checksum="2E4DB4BF48A23979" modified="2020-12-02" version="1">MMKNHTIMLVVLLGMDFLVNGLSLNNLEDEKIMDFDADNVPAEKRNLLQFGKMIRCATGRSPWKYNNYGNYCGSGGSGVPVDGVDRCCQAHDRCYDNNDHCNPKWKSYNYATAGTSPSCRITCGGSSSNDQCQTDVCECDKVAAECFARNTYNSNNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNB5</accession>
    <name>A0A6P8HNB5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Matrilysin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116291177</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554165.1">
        <property type="nucleotide sequence ID" value="XM_031698305.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HNB5">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="GeneID" id="116291177"/>
    <dbReference type="KEGG" id="aten:116291177"/>
    <dbReference type="InParanoid" id="A0A6P8HNB5"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027739628" evidence="17">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="18">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="15">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="190"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
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            <note>catalytic</note>
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        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
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            <dbReference type="RefSeq" id="XP_031554165.1"/>
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    <sequence length="301" mass="33152" checksum="AB6494C0865CE137" modified="2020-12-02" version="1">MKSLILLGLLACVAVTLAEDDETMAVKYLNQFHYISPSRSGNHDVETAVRNFQRFAGLPETGEIDEATVRQMKKPRCGMPDVDESGSRIRRYKLGSKWGKKHLTYFVEYGRDLSSGEQDRIFAXALKYWADVSGLSFSRASSASSADLKISFGPKTHGGSSERTCAYPFDGPGKVLAHAFFPSDGRAHFDEDERYTDXTSSGTNLLWVATHEFGHALGLEHSDVRNAVMYPYYTGYVPNFRLQQDDINGIQAHYGKAGGSTGGGSGGNCVDKNQNCRNWKSYCGRNSYVDANCKKTCGTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP89</accession>
    <name>A0A6P8HP89_ACTTE</name>
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        <submittedName>
            <fullName evidence="9">Melanocortin receptor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116291446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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            <taxon>Anthozoa</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00001">
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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            <begin position="6"/>
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            <end position="262"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
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            <begin position="20"/>
            <end position="260"/>
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    </feature>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031554475.1"/>
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    <sequence length="286" mass="32307" checksum="38708C850566B9EF" modified="2020-12-02" version="1">MLTLWLIIINVVLAFGAVSLNSLIILTFIKTSSLREKPSNVLILGLAIADLCVGIIAQPLSYIYDISVLKGYFGLQNSIQIVYFAFSFFLSIVSFLTFTAITVDRFLAIHLHLRYQALVTSKRYGVTLAGIWLLGFSMCCLLFQMKNSMAIVIPILYVILLVNAIFIFEISRVIRRHSVQIHAQQQSVQQVQSINMPRYKKSVNTMYYVAGAFVLCYFPFLAMISIVGIRKSGSLSIIRIWLPIFNTLAKAVSVIDPVIFWWRIKEMRSTVKICIRGTGTNMPNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ76</accession>
    <name>A0A6P8HQ76_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="15">Tentacle</tissue>
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    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031702659.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum lumen"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028303896" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
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            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031558519.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35703" checksum="3E92AF374190410D" modified="2020-12-02" version="1">MKTVLVCVLLVFVFSCFAAQDEATHKAHVHEDKLADADHYVDGEHNPEHDHEAFLGEEKEEFDHLSPEEAKKRLRNLIKKVDTDKDEAITTEELTDWVKKVFDERSLVGVDKDVEDKDSNKNGKVEWDEYVKGTYGETGEDDEEVKELLQRDRRRFDAADKDKDGALDKNEFGTFLHPESSPEMGDIHVTETIEDIDRDKDGFVNLKEFLGEYTDDESSEAPEWVHEETKRFHEEYDKNKDGKLDKDEVKQWILPETDHMMAVEEARHLVTSADENNDGKLTIGEIEKNYALFVGSEATDYGRALPHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQD1</accession>
    <name>A0A6P8HQD1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116293952</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557313.1">
        <property type="nucleotide sequence ID" value="XM_031701453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQD1"/>
    <dbReference type="FunCoup" id="A0A6P8HQD1">
        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="GeneID" id="116293952"/>
    <dbReference type="KEGG" id="aten:116293952"/>
    <dbReference type="InParanoid" id="A0A6P8HQD1"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.90:FF:000001">
        <property type="entry name" value="Transcriptional regulator BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050961">
        <property type="entry name" value="BolA/IbaG_stress_morph_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229">
        <property type="entry name" value="BOLA TRANSCRIPTION REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229:SF2">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557313.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14886" checksum="16145694DE479187" modified="2020-12-02" version="1">MIRAFPTLFRQQLICKTVFNSISTTLQKMSVQATITENLTKEFKPSHLEVLNESYMHNVPKGSETHFKVIVVSDVFKDKSLIQRHRMVNEVLKKELEGGVHALSIQAKTAEQWESSGQKVQKSPPCMGGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRD4</accession>
    <name>A0A6P8HRD4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555242.1">
        <property type="nucleotide sequence ID" value="XM_031699382.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292131"/>
    <dbReference type="KEGG" id="aten:116292131"/>
    <dbReference type="InParanoid" id="A0A6P8HRD4"/>
    <dbReference type="OrthoDB" id="10405294at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555242.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33999" checksum="F9E6491562DE7836" modified="2020-12-02" version="1">MDLDSSLNEELKSFVNEEFRNYIPVPSLAESSEFGILYFCTPVADDQSTNQSWFRTLSWPSLRQAHDSDSRSSSNLISLGWLFDHCPDNFGEVKTREEEVCIQGLASAXQKNRGITLEVPAVVGCGGSASCENNRVLDLGKIVKFSVPYKQISYWLKRVTPQDSPELFREAKRSHLYIIYEVLTAEHLKNKAVENSNIEGSVSATVPNGGVSGFGTWKRNKDCRLSRPKSMGRYPFAYKCGRVKVKKNKSHLKLVGLKEFYEPFKVIDQNKXPTYQSPSSSQEDEMSRDEFIVMKTEDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRM3</accession>
    <name>A0A6P8HRM3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292173 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555295.1">
        <property type="nucleotide sequence ID" value="XM_031699435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRM3"/>
    <dbReference type="GeneID" id="116292173"/>
    <dbReference type="KEGG" id="aten:116292173"/>
    <dbReference type="InParanoid" id="A0A6P8HRM3"/>
    <dbReference type="OrthoDB" id="5999297at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555295.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="20978" checksum="7521AF8FBFF99494" modified="2020-12-02" version="1">MAKTRKMTKTTNRHVPNSPSLSSQGNSISPSSSLEASPALAGKKAQNMHHTPELQSMDRDCTQDDDDETQDTESDTSTTDTMRLFDSSELPADDSENENSTSVLPEEMVPSLKITRHSALSIIKSVTGHLISRDDICKLLKSKFQISAKTLTPLTASELNEILARKLISNKYIVFKLQKSDITVVKEIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRQ8</accession>
    <name>A0A6P8HRQ8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116292228</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031555367.1">
        <property type="nucleotide sequence ID" value="XM_031699507.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HRQ8">
        <property type="interactions" value="1701"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292228"/>
    <dbReference type="InParanoid" id="A0A6P8HRQ8"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="15">
        <location>
            <begin position="145"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="462"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="17">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031555367.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="69333" checksum="28BDC2F4360C3BE7" modified="2020-12-02" version="1">VDFQKVRIQETQAELPRGCIPRSVEVILRAEAVEQAQAGDKCDFTGTLIVVPDVGQLTTPGARAESSERQRSGDGYQAEGIRGLKALGVRDLTYRMAFLACSVQSTNPRFGGKDLDEDMTAESIKKQMTEQEWQKVYEMSQDKNLYQNILNSIFPTIHGNDEVKRGVLLMLFGGVPKKTTEKTSLRGDINICVVGDPSTAKSQFLKHVEEFSSRAVYTSGKASSAAGLTAAVVRDEESNEFVIEAGALMLADNGVCCIDEFDKMDPRDQVAIHEAMEQQTISLTKAGVKASLNARTSVLAAANPIGGRYDRSKSLQQNVNMSAPIMSRFDLFFILVDESNEVTDYAIARRIVDLHRRLEESVERVYSVDEVQRYITFARQFKPTITKEAQDFMVEHYKHLRERDTSSTARSAWRITVRQLESMIRLSEAMARLCCSDEVQPKHVKEAFRLLNKSIIRVETPDIQFDEEDHNEEMDIXDNEDRSSAQTETPSNDMVNGETGQPSKSLLRVSYEEYKRLAQLLIRRLRKEEEKSETAEEKIRRSDLVNWYLKEIESEIESEEELSQKKTLVDRVLDRLVDHDKVILALQEYQEDKASEPEDPYLVVHPNYCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSP4</accession>
    <name>A0A6P8HSP4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555705.1">
        <property type="nucleotide sequence ID" value="XM_031699845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSP4"/>
    <dbReference type="GeneID" id="116292503"/>
    <dbReference type="KEGG" id="aten:116292503"/>
    <dbReference type="InParanoid" id="A0A6P8HSP4"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555705.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30576" checksum="F4C9463D006ADE65" modified="2020-12-02" version="1">MSDTKVACRQLGFTKAVGPSYEGRGTVCRTNWDMPDANVGYHQFGFARAVGASYEGRGTGKVWLYNMQCTGSETALGSCPHNGWGNVMWSCITMVNGERYVKVYHQGQWGKVCSDGWYMEEAKVACRQLGFTKAVGASYNGRGTGRVWLNYMGCTGSESDLGSCSHNGWGHGWGCDRTTNVGVVLHLAAILTSFVEVYHQGQWGTVCNYGWNMPDAKVACRQLGFTKAIGASYLGRGTEVYHQGQWGTVCHGSWGMDDAKVACRQLGFTKTVGASWLGRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTR1</accession>
    <name>A0A6P8HTR1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane prolyl 4-hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116292789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031556002.1">
        <property type="nucleotide sequence ID" value="XM_031700142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTR1"/>
    <dbReference type="GeneID" id="116292789"/>
    <dbReference type="KEGG" id="aten:116292789"/>
    <dbReference type="InParanoid" id="A0A6P8HTR1"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="218"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556002.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="45410" checksum="6DCE4D76B0A8FD58" modified="2020-12-02" version="1">MAEHRLVRIDGVKVGHVQEVELEEGRRYTMITKAMKPVMFEIPNFLSNDECDYIIKLANLTGLEQSVAGFIKDRYDGELDQQINAVDETRPAEGPDELRAEKFDWWDENNDSVIDEQEIIRFARNYDKLYLKKQEIQDMLKRIGFQGYKKCEITRKEFEERGIKKILAYMHFLKDKHPLHRHRLSDQTWLYRNMSDPVLSRLINRVTKLTRLPRKFVRASEAIQVVRYQQNGHYHAHMDSTPIRNDELYCCHQNLYKKKECKLCRFITILYYLNDVESGGETAFPIADQDTRPLDKRLVDPGISHDELNLTEHCQNASLVLPPKKGTAVMWYNHYVDTDSGYLGDLDEFSVHGGCDIKKGMKWIANNWINAPVAKTAHIKSIYDVDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTW3</accession>
    <name>A0A6P8HTW3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Testin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC116295238</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10 11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558864.1">
        <property type="nucleotide sequence ID" value="XM_031703004.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558865.1">
        <property type="nucleotide sequence ID" value="XM_031703005.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558866.1">
        <property type="nucleotide sequence ID" value="XM_031703006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTW3"/>
    <dbReference type="GeneID" id="116295238"/>
    <dbReference type="KEGG" id="aten:116295238"/>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09345">
        <property type="entry name" value="LIM2_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50270">
        <property type="entry name" value="NGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="7">
        <location>
            <begin position="144"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="249"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="374"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="438"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="498"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="558"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031558866.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="69245" checksum="E07EB88C419CB9F7" modified="2020-12-02" version="1">MNQSRGKTRYKPPVDTYTEALYSDEIQMSQERSSASKKGILLQDIDEGKPCLRCGSKCPGFSLHIWKKNCTYCKCPRENHDIETNVDISSGVNGIQFKIGGLKLDDNNGFGSDEYLPPPPPPLTIYQDEGDDFPDVPAIENDAQSSFPAPPIITNGNKSTKTYLWAPPGLNSSQVEEYFKEIPSEKVPIPGTPGMKYYDEQCTFQNPPQDRAKMANVSPEKRDGIAQFWKKEEQTKGYGVVKLPFGSKQRCFRCSRPILRSEPAVIAEDIGKEAVYHPACFSCETCDELLVNLIYYRSDDEVYCARHHAELTKQRCGGCDELIFSGEYTVAMNRSWHLGHFRCQRCDSSITGKQFIVLKDKPVCNDCFKDSYAHECHACGQKIGPESRDISSDDKRHWHDYCFKCDLCHRPLQSDGKFTFYKDKTLCTTCYATNYQKACKACNKPIDSGGSRLEYNGNYFHEHCFVCKICSKEIGTSGFVPKDDEFYCPSCFQNEFSKRCAGCGEPLLEGGVLYGGQTWHKTCFTCHYCHRSLAANAFSVRDGFRYCMECYGTFYAKQCEICMKPIVGGEYYTLDESNFHKDCFMCSRCSRSLASEGFVREGMELLCANCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU91</accession>
    <name>A0A6P8HU91_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Adhesion G protein-coupled receptor L3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558798.1">
        <property type="nucleotide sequence ID" value="XM_031702938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU91"/>
    <dbReference type="GeneID" id="116295186"/>
    <dbReference type="KEGG" id="aten:116295186"/>
    <dbReference type="InParanoid" id="A0A6P8HU91"/>
    <dbReference type="OrthoDB" id="5986747at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000058">
        <property type="entry name" value="Adhesion G protein-coupled receptor F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="11">
        <location>
            <begin position="148"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="328"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558798.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="71450" checksum="67CC0D7857498DAD" modified="2020-12-02" version="1">MHVSSTVVSLKSPVSTSLPTTSVSTNVHAVSSTPSLPSTTIISSNYADDHTTASPSVYSRKSLQEITTTSEIESSFSNLNSTEVTKYLQQIRDLDSTLATSAKFASELTTNLLKSFTTSNKHSSKPMIAIDTFENFLSEYGQQHLNYSNREIHWDTASMAVQIMRIYEPFDGIQLHSPNNDVSIYFQQENFINGTIVVQVIYNDLHHILPSLFTGNAEKLEIGSKITSILRGLPSNQTAFKTNVTISFMNLKGARPKGTPNGSRKCVFWLFSPRNSEQKDGKWSDEGCTLLHSSDDETVCSCNHLTSFAVLMQTPGKNKISSFDQDTLSLLTIVGLSLSLFGSTVTFIAYITLTDRKSNLSQIRLNLVASLGMAHFLFVTGIRATHFPAICVMVGALLQLFFLASLCWMLVEGIQLYFRIVRVYNSEMTIKACYLFAWGFPAFLVCVSLSISSFGPKGIYGFVQEDICWVSHYLYLAWVFNVPMSLILLANLIFFLRVMKEISKMKIRQPKPQRLSVVRRNLKACCLFFPLLGITWFTGCVIMFHPYVILIYIFTILNSTQGFFIFLFHCVGNREIRSAFKKKIYPNDVSRMEKRNEPIPLAIASVSNVFCDGIHPPDDPRDEDKALPAGHKPNYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUJ1</accession>
    <name>A0A6P8HUJ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116295298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558938.1">
        <property type="nucleotide sequence ID" value="XM_031703078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUJ1"/>
    <dbReference type="GeneID" id="116295298"/>
    <dbReference type="KEGG" id="aten:116295298"/>
    <dbReference type="InParanoid" id="A0A6P8HUJ1"/>
    <dbReference type="OrthoDB" id="5985863at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558938.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23728" checksum="176B061B2A00CDCD" modified="2020-12-02" version="1">IIDIDQPGPTVVQGLPTALTCPVFGYPEPFVAWVRDGVIHQNTTTTSVFKENELNENRNQSKWECIVSNIHGSDFHQFHITGVSWHRMCAKHHILATKRTLNDVISSPDQASNDTSVNESVWFRLQDPVTSQSMQIPESCTPSMHCSTQATGWLLGSHPGIQDGVVRRTVCFNWDGNCCKYNTTILVRRCHGFYVYKLQKSSFDVHAGYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV83</accession>
    <name>A0A6P8HV83_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Iron-sulfur cluster transfer protein NUBPL</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nucleotide-binding protein-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116293314</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver one or more Fe-S clusters to complex I subunits.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556590.1">
        <property type="nucleotide sequence ID" value="XM_031700730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HV83"/>
    <dbReference type="FunCoup" id="A0A6P8HV83">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="GeneID" id="116293314"/>
    <dbReference type="KEGG" id="aten:116293314"/>
    <dbReference type="InParanoid" id="A0A6P8HV83"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000709">
        <property type="entry name" value="Iron-sulfur protein NUBPL isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031556590.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="35406" checksum="6AE49040DF6351A7" modified="2020-12-02" version="1">MAACRMFSRTSCVCTIISATKTCFRLIPRSASTHETPFGIRGQGNDPSTGSPQAAQNRASRGLPKKWPIAGVQHVVLVASGKGGVGKSTTAVNLALAMLSSEKSLSVGLLDADIYGPSIPLMMNLKGQPELNKKNQMKPLINFGLPCMSMGFLVDEGAPIVWRGLMVMSAIEKLLRQVAWGPLDVLVVDMPPGTGDIQLSISQLIPVSGAVIVSTPQDIALMDARRGAEMFRKVNIPVLGLVQNMNHYVCPNCNHTAYIFGQDGAKDVARDLNIEILGNVPLDIQIRETADQGKPIVVSQPSSPQAQSYLQIARRILEKLPPEKSMDPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW62</accession>
    <name>A0A6P8HW62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c oxidase subunit 5B, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556880.1">
        <property type="nucleotide sequence ID" value="XM_031701020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW62"/>
    <dbReference type="FunCoup" id="A0A6P8HW62">
        <property type="interactions" value="1190"/>
    </dbReference>
    <dbReference type="GeneID" id="116293576"/>
    <dbReference type="KEGG" id="aten:116293576"/>
    <dbReference type="InParanoid" id="A0A6P8HW62"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556880.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15313" checksum="4F4D27C237BA55C3" modified="2020-12-02" version="1">MTSLLLRSIRSSTIRPCMRLMNSRLTPAIISRGLATEKDSKPSIATPEEMATGLEKLEYDAVISGIEDPFRLKMATGPPGTLEKPTEVPTAFGERIVGCVCEEDATMIKWMLVKKGEPQRCDCGHYFVIKDANPIDIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXA3</accession>
    <name>A0A6P8HXA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296188 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560033.1">
        <property type="nucleotide sequence ID" value="XM_031704173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXA3"/>
    <dbReference type="GeneID" id="116296188"/>
    <dbReference type="KEGG" id="aten:116296188"/>
    <dbReference type="InParanoid" id="A0A6P8HXA3"/>
    <dbReference type="OrthoDB" id="5953028at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560033.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28092" checksum="76FEB8BB76A7E841" modified="2020-12-02" version="1">MMGSILSQNSNDTKGKDEDSTLIEMISSQGKETTTDEYRRSEAYLKMNQCRIANCPTDPNAHQFVKTFRELQGKKEHFYVQLHNEVIQWRLMFQRGVSNKFENNDKVNKLIGEFITIHEKLDDFLEEERKNIEQILPKRKALKDVSDGQKKSKKDSLIQGERESLELTPEAMQRLMCFQQCNDQHIRILTQVLSDIEDCKKFESAKTKQETKEVQPAPSNKPVSITVSSVDSEEFGIQSESHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXB7</accession>
    <name>A0A6P8HXB7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116296153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116296153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559981.1">
        <property type="nucleotide sequence ID" value="XM_031704121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXB7"/>
    <dbReference type="GeneID" id="116296153"/>
    <dbReference type="KEGG" id="aten:116296153"/>
    <dbReference type="InParanoid" id="A0A6P8HXB7"/>
    <dbReference type="OrthoDB" id="5960532at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF125">
        <property type="entry name" value="B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="9">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="10">
        <location>
            <begin position="172"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="10">
        <location>
            <begin position="380"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="10">
        <location>
            <begin position="590"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559981.1"/>
        </source>
    </evidence>
    <sequence length="870" mass="97234" checksum="6000E8803D2CA0C2" modified="2020-12-02" version="1">TDLNNIAKFQKVIWNSNGNYFFPLLTVTYCYHKVIYGISGLFIENTYHFSGKALNNHAIKTTQVSSKINCVFQCLSVEQCVSYNYQETSSTGRHTCELNRKSFRNAKLEDFQARDGFVYGESVPQTSQSGSCATSPCKNYGICMNIGNDMYECICKATTTGNDCEQWKDNAKDYTLTFPRKSTSDVISAVSLNSSQVSKLTMCTWVNYVTAGWHTLFSYSVKNAANMLAIRCDNTGKCEIIVNNVPSEVHTSPLNDGTWHHLCFSWENIQGSLKFYINGAIRSIKKDVSSSLTIDGTGKLIIGQLQATSVGLEFNASDSFMGRMYGFNMWDAVKSPSEILSLSKQCISETGNLVDWRIFSVKESHGLVNQAMPSVCAFNVSKTANFESSSGEKYIKMPFTTTSLREITICFWSRRKWTKKSTAFHYYSETLKNALRWTFNGATENMIFVANVKTSIYFSPYYDDSWHHFCYTWESTDGRLVVFIDGIVIYNASSVDRAKTIEGTGVLVIGQLCSTLNPFSASDDCFYVNYLTDLNIWKTSLSGHVITAMSKAAGRDLGNKLNWNDVVYGGEVFGGLSLTPTNDVSLNGNSDFYIDFGSTQSASNYVEFQNPIPSVTQFLACYWLWPTNKGGVFAYSTPELADQWATFISTSDASFCINEKWKYGSTVTFNGGWSHFCWRWRNTDGLTELYKDGKLLMSLTGFVTGYTIPGGGYLVLGQEVDSHKGGFSASQALTGFLGHLNIWDNFDAVALSFEEMARGASHFEGNVVPWSSFRSKLYGTVTVVEGSSCTLPDFATQKLREKWCSDNISPTSDCPVLYPLLDTDNNNNGKLLRCYCKNMLLQNSAGHYTYNPGNTGYYTRDPQLRLIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXT1</accession>
    <name>A0A6P8HXT1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116296299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560183.1">
        <property type="nucleotide sequence ID" value="XM_031704323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296299"/>
    <dbReference type="KEGG" id="aten:116296299"/>
    <dbReference type="InParanoid" id="A0A6P8HXT1"/>
    <dbReference type="OrthoDB" id="5975210at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26129">
        <property type="entry name" value="Vwde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="14"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="168"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="319"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="471"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="621"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="776"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="933"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="3">
        <location>
            <begin position="1310"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1860"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="2012"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="2169"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="2324"/>
            <end position="2474"/>
        </location>
    </feature>
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        <location>
            <begin position="2481"/>
            <end position="2632"/>
        </location>
    </feature>
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        <location>
            <begin position="2636"/>
            <end position="2782"/>
        </location>
    </feature>
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        <location>
            <begin position="2789"/>
            <end position="2940"/>
        </location>
    </feature>
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        <location>
            <begin position="2944"/>
            <end position="3095"/>
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    </feature>
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        <location>
            <begin position="3102"/>
            <end position="3253"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="3257"/>
            <end position="3407"/>
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    </feature>
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        <location>
            <begin position="3413"/>
            <end position="3564"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="3568"/>
            <end position="3719"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="3729"/>
            <end position="3880"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="3884"/>
            <end position="4035"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="4041"/>
            <end position="4192"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="4196"/>
            <end position="4347"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="4359"/>
            <end position="4510"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="4514"/>
            <end position="4665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2500"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2509"/>
            <end position="2523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560183.1"/>
        </source>
    </evidence>
    <sequence length="4669" mass="543145" checksum="F27FC0FC4E562680" modified="2020-12-02" version="1">[encoded data, 4669 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXU5</accession>
    <name>A0A6P8HXU5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296297</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560181.1">
        <property type="nucleotide sequence ID" value="XM_031704321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296297"/>
    <dbReference type="KEGG" id="aten:116296297"/>
    <dbReference type="InParanoid" id="A0A6P8HXU5"/>
    <dbReference type="OrthoDB" id="6126625at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="2"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560181.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23107" checksum="761450A13806F488" modified="2020-12-02" version="1">MFCSNCGHQIENLDKFCPNCGKGLTEDASDSDTDSEVEFDEEDVIKYYFHRGFEYQEIILFLAKNHNHTISYSTLLRKLKLYGLSRXNLNRRHKQTDVXKRIEEIVNGPGSSGGYRSVWHTLRLEGFSVPRIIVQQLLQEIDPEGVATRKGHRLKRRVYRNPGPNYAWHQDGYDKLKPWGFPIHGCIDGFSRRILWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYQ6</accession>
    <name>A0A6P8HYQ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein LOC116296547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116296547</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560440.1">
        <property type="nucleotide sequence ID" value="XM_031704580.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560441.1">
        <property type="nucleotide sequence ID" value="XM_031704581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYQ6"/>
    <dbReference type="GeneID" id="116296547"/>
    <dbReference type="KEGG" id="aten:116296547"/>
    <dbReference type="OrthoDB" id="5958717at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031560440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031560441.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32245" checksum="53CE3976FEA6119B" modified="2020-12-02" version="1">MGISCSNTVTLAKDNQVSRSTPSTNGSISINTTASKTIQSASVWNPFSITRAEAEDLLQESDPGSFVFSYDMTSELFLSLSAGKYVCHHSVVTRDNSYYVGAKRFDTVGEVIGYFKDHPLGEITLKEEYKKPSLNTTNIQVKQHPDVLIQSPATASSSDVSSSENESRKVTLTQLPNQAPETSPAIRRYQHQRATVPVERIDEEEYDANNKTEMVERNNRANRTTNSSLRLPRNKIEPLPRKPLLRSEAIDQDQQESSSSGADREVPSSISLMPLIPQQDYQMRSSPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0P7</accession>
    <name>A0A6P8I0P7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116297253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031561303.1">
        <property type="nucleotide sequence ID" value="XM_031705443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0P7"/>
    <dbReference type="GeneID" id="116297253"/>
    <dbReference type="KEGG" id="aten:116297253"/>
    <dbReference type="InParanoid" id="A0A6P8I0P7"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047220">
        <property type="term" value="F:galactosylxylosylprotein 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561303.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="46339" checksum="E2F29395B4E6BC9E" modified="2020-12-02" version="1">MRFSLRIVIGLGVFSIIGYGIHYFKYLSTGKPSITQPPYTDQGVSSRAAAQLKNIQSPGQSSNNSTSMRPPQTTCGKTVASELIDLKSITPPGRPKVIIFINIPAAGGWSIRRITLRKTWLSTAKNYSIAYRFFTDSIGVKPEVIKTLEKEREEFRDLEFIPTRSGYWLTHRYLFAMFWGYEHYDFKFYLKFDDDYFVCLNNLMNDIQYRMNEKLLYWGWFGCDPKMVAMDEGFVMLSVDLVEEIMKRNNSLCCHPFGGQMIAMWMNRLEREGYDTTYFPDNNRLMHIRSHFKQGPSKDMCKKLLGIHQAYPKYMWQYWNLTKDSWFSLKGDDFEKVERKPFNSYCKLKKEWDWRVLGSFWKHEPKPCWLPGLEWDARLQKYKNVQSRELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I227</accession>
    <name>A0A6P8I227_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Golgi-associated plant pathogenesis-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116297705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561848.1">
        <property type="nucleotide sequence ID" value="XM_031705988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I227"/>
    <dbReference type="GeneID" id="116297705"/>
    <dbReference type="KEGG" id="aten:116297705"/>
    <dbReference type="InParanoid" id="A0A6P8I227"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027863064" evidence="2">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031561848.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22179" checksum="7F4691E34DE8D7B6" modified="2020-12-02" version="1">MNFWTRLVLVMAILGHYKVTVLSKAKEGCGDTCQKECLSVHNEYRANYGAQRLELDGRLAAQAQEKIDRGVLAHSQSIKSKGGESIAWGSLFPTFTSAIKSWHDEKVNFDFEDPKPLSEGKVVRNFLQIVWKGTRKIGCARGPLYGKPWYVVHYDIAPSQGDAAAIRENVGKPKEDDMGWFRDSSPFAQDFENPRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2B7</accession>
    <name>A0A6P8I2B7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297787</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561943.1">
        <property type="nucleotide sequence ID" value="XM_031706083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2B7"/>
    <dbReference type="GeneID" id="116297787"/>
    <dbReference type="KEGG" id="aten:116297787"/>
    <dbReference type="InParanoid" id="A0A6P8I2B7"/>
    <dbReference type="OrthoDB" id="5990004at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561943.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29677" checksum="EC1A75205E58E12F" modified="2020-12-02" version="1">MQHIKDTMHSRLDFSLLVVHSLILIIITKDSLEEKVLIIKNKTSNTTTNNLLPYKYLLNTSDIQDNFVDKTSGSTKYKTGFYTPTASINSSKITANTTKNRGNAKKSTVVLLERTFMTTTRSTKNSNITTVVPPYHPTSNPSYTSKILQYTLIPLGCVLFIIALLCMVRHIQKVKKKRRLERELLHQYSYPNSEAGDLDEEERFLEVESVINTQFNISSDQEEKNVVDEIPQVTVAIGDGSKLVMQDTQSLSDDVEASTSFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I556</accession>
    <name>A0A6P8I556_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polycomb group RING finger protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116298659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563043.1">
        <property type="nucleotide sequence ID" value="XM_031707183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I556"/>
    <dbReference type="FunCoup" id="A0A6P8I556">
        <property type="interactions" value="1987"/>
    </dbReference>
    <dbReference type="GeneID" id="116298659"/>
    <dbReference type="KEGG" id="aten:116298659"/>
    <dbReference type="InParanoid" id="A0A6P8I556"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051507">
        <property type="entry name" value="PcG_RING_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45893">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563043.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27807" checksum="77AB247B474D5C80" modified="2020-12-02" version="1">MERTIKLCAVREHITCGLCGGYLIDATTIVECLHTFCRSCLVKHLRECNFCPSCKIVLHQSHPMNYISTDRTLQDIVYKLVPDLQEREIQRQKEFEVAMFMYRTGEQQNIHNNSQKNISSPKPKVETYADTSTSKEDYHRNDEQTAICMECYRSSNGKYLLKPLTRKYLKLSSQATVQHLKKFIAKKLALDNHTDVDILCNDEILGKDHTIKFIMVTRWRCKDSPLLLHYRPSLKLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6R9</accession>
    <name>A0A6P8I6R9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Ephrin type-B receptor 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC116296533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560420.1">
        <property type="nucleotide sequence ID" value="XM_031704560.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560421.1">
        <property type="nucleotide sequence ID" value="XM_031704561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6R9"/>
    <dbReference type="GeneID" id="116296533"/>
    <dbReference type="KEGG" id="aten:116296533"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653141" evidence="10">
        <location>
            <begin position="25"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="12">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="326"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031560420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031560421.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="71071" checksum="CF7C67D210281947" modified="2020-12-02" version="1">MYPSQKNSLFLALVVARTVAAVLGYEEILMNYAYTDPAWQWVTKYRLAEGNGWARDSQTGKYITCDIPSTKTNSTNSWMISDYVPLNNANAVHLSITFTARHCDLASYPFCKNSIGLYILESDIIEVGGITMEAILAGNFSNVADAIASNVWTDRNNIPENVHNVSFPTTKKGIYLAFRDTGACVALVKVRMTSYQCPSVVSGGAVFNKTASPMPGLKTKVKGECLGMSENLANGSSLYLGCYSNGTWSSNLRVTCQCKAGYQPGDRVCQACPDGSYKPTTGNTMCVPCPVNSYSNTTRTGCLCSMGYYRTNSDPPNGKCTAPPSSPRDLSSTLIGPRFVLLSWQRPLNDGGHNDLLYSIDCYRCNHGNTRDYDNSRNVSRYCNQSCESTLRYTPSANKIPFTHVTIFGLAPGFSYLFRVTAENGVSRLGTNVTDNYTEVSTSIPNPVVPKLIVSFVGSDVTVLSWSSKEDNQSTSFFYYSVSCAACDKELSDCITSCNTACGNAIQYLPRKDQIEGSFAVVSQLKEATKYKFKLSVTERDSDGYRSDTSVVCVTTKNSGNAAEVNGQRDQGKDISLYSKIALGVSGGFLLLSIVLLMVTVCLRNKWYRQAKSMHSGSSASAFSYTNELKPIENLVFMEETNLENVRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8I6</accession>
    <name>A0A6P8I8I6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296979</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560975.1">
        <property type="nucleotide sequence ID" value="XM_031705115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8I6"/>
    <dbReference type="GeneID" id="116296979"/>
    <dbReference type="KEGG" id="aten:116296979"/>
    <dbReference type="InParanoid" id="A0A6P8I8I6"/>
    <dbReference type="OrthoDB" id="10274567at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560975.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24279" checksum="633A64832EDC4538" modified="2020-12-02" version="1">MSSGEEMLLDVEITSSNPSSCAPYALIITNTVLVSVVCLRPEFYKIKTAVLAILFGSDSIAFFIGVMNSMDYLTREDHLERQNKGNQTCLIYRLQANVIALLFNAALVIVVNQRTKKLKSPEKVPVTLSNVLCVLFNGIAWYIPNEINRQFHFSMYITVQGDWIQSEIWGLDLIFVLYFYRGIFIGLSFISDYLNAKNEEDDERELRYISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8Z1</accession>
    <name>A0A6P8I8Z1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116299948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564538.1">
        <property type="nucleotide sequence ID" value="XM_031708678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8Z1"/>
    <dbReference type="GeneID" id="116299948"/>
    <dbReference type="KEGG" id="aten:116299948"/>
    <dbReference type="InParanoid" id="A0A6P8I8Z1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF20">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 8 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="151"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="592"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="709"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="768"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="243"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031564538.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="98550" checksum="18C91EAF12DEB2BD" modified="2020-12-02" version="1">MAGSGLRETLQHYSLEKYYNTFTSVGIDDIGGLLALTMQDYPALGITSMQDRRKMFHLIQNVKDKSSINRKDTDVVSNESSSAGQQSVTKKPKEQEIKSRKESQPLRPESTHPSGTILREYTTHDFSYGIPSSKVKPKTPSRPRANSENSKIKVCVRKRPLGGEEVESGETDVVDTVPSKSMVVISAPKVAVDLTKYIQKFSFAFDEVFDENTTNRQVYEKTCKPLVNEIFTKGIKATCFAYGCTGSGKTYTMLGTDNIPGLYLLAASDIFSILYSGNHGNDLGLWVSFYEIYCGQLFDLLNERSKLFARENAAHQVCIVGLTEKHVTNVEELMEVIESGGNSRSTGSTGVNADSSRSHAILQLDLKDSEYGETLGRFSFIDLAGSERAADVTDSDKQTRMEGAEINQSLLALKECIRALDQDSRHTPFRQSKLTQVLKDSFVGNTKTCMIANISPCSSSSENTLNTLRYSDRVKELNKNEAVINTSPRPVTVHGNDSEKWIENQKYSPRNMNSLMKIKEQQTSKKSLVKPRSSDHFNLIPNNKLNVNILQVGNLTTNKPKTPQLNTKNKKARNQSTLIKSLEPLPSKFVRNTLEKPRPDTSPAVINVPREQKPRPTRRLQYVHKEQYQNTSKEEKYEETIESNIMEEKPKRQIKSRLSDKRSNRNTQSSLSEKPTENLSISTHNLVSQNLDVLRTSVNQQLTVPVSSHYGERAKQSISSAKPKISHNEQKPVDSVGTLEPNKTDGTPNNRYSRGIKAKLAQLFNSKPTTSSTEILPDHKQLSSTSSSVRSKRALQPIQQTVSPRVITEDQIVAAHHTQLAMVTGLCHEEMILLKERDNNKQDFKEYAFQLEEILLQKQACIENLQEKLKKWKTTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I952</accession>
    <name>A0A6P8I952_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116297154</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561180.1">
        <property type="nucleotide sequence ID" value="XM_031705320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I952"/>
    <dbReference type="FunCoup" id="A0A6P8I952">
        <property type="interactions" value="2286"/>
    </dbReference>
    <dbReference type="GeneID" id="116297154"/>
    <dbReference type="KEGG" id="aten:116297154"/>
    <dbReference type="InParanoid" id="A0A6P8I952"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031561180.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="31293" checksum="7C6DBE40F938A450" modified="2020-12-02" version="1">MGKPGFSPRGGGRGGGRGGGFGGRGGRGGGRGGGRGGGRGGFGGRGGRGGGRGGMKGGAKVTIEPHRHEGVFIARGKEDALITKNLVPGETVYGEKKISVDGVNEGEKIEYRVWNPFRSKLAAAILGGVDKIHMPPGSKVLYLGAASGTTVSHVSDIVGPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPDQTRIVAINAHMFLKNGGHFVISIKANCIDSTAQPAAVFAGEVKKMQGEKMKPQEQLTLEPYERDHAVVVGVYRAPPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I986</accession>
    <name>A0A6P8I986_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="14">1.8.5.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sulfide quinone oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116300014</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol</text>
            <dbReference type="Rhea" id="RHEA:55156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.8.5.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10</text>
            <dbReference type="Rhea" id="RHEA:62608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate</text>
            <dbReference type="Rhea" id="RHEA:38359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38360"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SQRD family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.8" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031564633.1">
        <property type="nucleotide sequence ID" value="XM_031708773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I986"/>
    <dbReference type="FunCoup" id="A0A6P8I986">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="GeneID" id="116300014"/>
    <dbReference type="KEGG" id="aten:116300014"/>
    <dbReference type="InParanoid" id="A0A6P8I986"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106436">
        <property type="term" value="F:glutathione-dependent sulfide quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031564633.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48929" checksum="C2945CE698D274A1" modified="2020-12-02" version="1">MFGKRLFFLAAKNRSLSTSTVSHARLSYQFVIVGGGAGGLSIASSLCRKFGKNSTAIVEPSEFHYFQPKWTLVGGGIKEFHESQARTRDVMPKLTSWYKTGASEFKPDDNLVICEDGTELSYEYLIIAVGLQNRFDLVKGLPEALHTPGVGSNFAPGTVVDTWKSIKNFKGGNAIFTLPNTRIKCPGAPQEIMYIAEEQFRKMGIRHKSTVMFNSALDKIFGVEKYAKLLKRIIKNRDIKLNFLQNLVEVNAETRKAIFEILDGADPENKKYETYKYDLLHVTPPMSGPACLDGSPISDKDGYVDADQVTLQHKIYRNIFGVGDCTNVPTGKTAAAVGVQCNTLKKNLLSLMKGKPLAEKYDGYYTSCPLVTGYGKLILAEYGYTCKPLETFPFDQGKERMSMYFLKQEILPQVYWHGLIKGLWPGACVARKAFHLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9B9</accession>
    <name>A0A6P8I9B9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine O-palmitoleoyltransferase porcupine</fullName>
            <ecNumber evidence="9">2.3.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116297591</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA</text>
            <dbReference type="Rhea" id="RHEA:45336"/>
            <dbReference type="Rhea" id="RHEA-COMP:11170"/>
            <dbReference type="Rhea" id="RHEA-COMP:11171"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:85189"/>
            <dbReference type="EC" id="2.3.1.250"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.250" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031561712.1">
        <property type="nucleotide sequence ID" value="XM_031705852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9B9"/>
    <dbReference type="FunCoup" id="A0A6P8I9B9">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="GeneID" id="116297591"/>
    <dbReference type="KEGG" id="aten:116297591"/>
    <dbReference type="InParanoid" id="A0A6P8I9B9"/>
    <dbReference type="OrthoDB" id="5968863at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990698">
        <property type="term" value="F:palmitoleoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF12">
        <property type="entry name" value="PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031561712.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53984" checksum="CDC3E31B1F83CB30" modified="2020-12-02" version="1">MEDFDLADLENDFMYEDLSPDLYEYYQQEDLSSRRFGFMHTFNQCFWPTTTQTGEIVGPLLGLCLVVRVISILPVPRWTVHLVSLVTGCITMYVFVNQYVWYPIIMCLVGYPLVFVPKGYRGPLMAALCLAYILTCEIFIASPDSWHKVRGSQMILAMKIISIAFDSDQGLLSKTPNPLEYFGYALSANAVIFGPFMSYENYSQILAGKRLSFSWFFGVLRSFVLCYVCLIYSVCISPYIFAQNDHKWLVAYQTAMSFRFSHYFVSYMSECTSVVSGVGTEVTQDEKKVTKWQFDVARPQHVELPRSLVEVVIHWNVPNHVFLKNYVFKKARSLGRFVAILLTFGCSSLLHGLNFQLTAVLLSIGMYAYIEHVFRSKLASLFSACIMARKCRPDCGHFHKEGQFWVLATNLSFGFLSVFHLAYLGIMFGGDASEQTQGSSMSFTLKKWTELDFASHWVAMATLLLSIIIPKTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9V3</accession>
    <name>A0A6P8I9V3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299441</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563961.1">
        <property type="nucleotide sequence ID" value="XM_031708101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9V3"/>
    <dbReference type="GeneID" id="116299441"/>
    <dbReference type="KEGG" id="aten:116299441"/>
    <dbReference type="InParanoid" id="A0A6P8I9V3"/>
    <dbReference type="OrthoDB" id="6621683at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="65"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563961.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36873" checksum="28B12D8FEA4E3306" modified="2020-12-02" version="1">MGRTEDKLKRIYYGSEGYWRGASAIKKLATAARVSEETAKNWLKKQTLWQVYLPVPKYIPRPSFTVNAPNEVHEADLLFLPHDTVRRKTYRYALTVVDIASRYKDAEPITSKDFGEVAEALGKIYKRVLKWPKLLQVDSGTELMGVVTKTLKDHDTKIRRAEAEYHRGQSIVERFNKTLAERLFGYQYWKELEDPSKRNKEWTQRLPQVVAALNNEAARATGMKPKDAIKKKHVEHKSYVRSSRAVGLKEKKLPRDIVVRYLYQPGEGGSKRATDPNWSLKTYEISKSVTKEGQPVLYYLNGPSRGFVKEELLIVPKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICH8</accession>
    <name>A0A6P8ICH8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">legumain</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116300537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031565281.1">
        <property type="nucleotide sequence ID" value="XM_031709421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICH8"/>
    <dbReference type="FunCoup" id="A0A6P8ICH8">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="GeneID" id="116300537"/>
    <dbReference type="KEGG" id="aten:116300537"/>
    <dbReference type="InParanoid" id="A0A6P8ICH8"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.130:FF:000001">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043577">
        <property type="entry name" value="AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500139">
        <property type="entry name" value="AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028429892" description="legumain" evidence="9">
        <location>
            <begin position="28"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="10">
        <location>
            <begin position="342"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031565281.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49993" checksum="35A829C3239DC8E7" modified="2020-12-02" version="1">MACLNVLRLLAFTFLYVHLGYINEALATEGKHWALLVAGSNTWGNYRHQADICHAYQVLHKNGIPDENIVVMTYDDIAYNEQNPTPGTIINKVGGPNVYKGVVKDYTRKEVTPEKFLRILKGEKSLMREFGSGKVIDSGPDDHVFVYFSDHGAPGLVAFPEGELMANDLNDAIHYMHTNKKFKKMVFYIESCESGSMFNTLLPDNIKVYATTASTPNESSYACYFDKKLETYLGDVYSVKWLENSDSSNLRVETLLQQFKIVRRETNTSHVQKYGDMSFENEVLEDFLGGPEKVEQNVLQNQAKIIQPEFDAVPSPDVPIAILEHKLENAKDPETKKLIKDDLEKEIKMRLKIQDTVRQIAEHASQNNLQIQRVIEKAAVPRDYICYKKAIKAFKTFCFNFQEYEYALRHVYVLSNLCEEHVPVERITDAITSVCGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID27</accession>
    <name>A0A6P8ID27_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ral GTPase-activating protein subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563175.1">
        <property type="nucleotide sequence ID" value="XM_031707315.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ID27">
        <property type="interactions" value="2512"/>
    </dbReference>
    <dbReference type="GeneID" id="116298735"/>
    <dbReference type="KEGG" id="aten:116298735"/>
    <dbReference type="InParanoid" id="A0A6P8ID27"/>
    <dbReference type="OrthoDB" id="10009983at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1206"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="917"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1344"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1464"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1486"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563175.1"/>
        </source>
    </evidence>
    <sequence length="1689" mass="188626" checksum="0DA6B252C12216D6" modified="2020-12-02" version="1">MYSEWVSLNHTLRADKRNRSVLRSFPRHVGREIAHTIVTTLIQDQGLPDKKKLSSSSEVDWVMEVFCYGLSLPMTETDGEIIKGCVNVYIEWLGVMLMEDRDKVIPEPLLKEPVKYVQKIFQHLKNLFLIRNDNGSNLALQASLCIRVLQFFKVIASESQLSPEIWDALLCLMLVINEQLLSPPYSAGGLSEHLKEILINSLLEVWLHASVQYFPPPSMWKTLQELCMSWRHHNAMIEYWSSTVLMLTRKVIKYLYGNSFPLPPLKSKKNEVQIPAVMNKETLLQTWFRILHIISNPVDLCNREIISDTGKFKEFALSCQDVTYPSAHPCLDCLPEIFLQAMKGIAVMVNTFLCITTTHNQPVKHNPINAPVKGSSPSASKKREIKTLSTGLALGLADNKGLGIRSLTMPSRHSSGTSMTGVPMPDDEMIGDEKESQTPASSLFSKSPSSTTAPSVDSVLDLYGAWLFDAAFAKVDMKASYEAIGDIYAKCCETSENAERNIHSPRKISVESSSSIAKKDYADDANFEPGRAEAFGALCRIFCSPRAEKSIRPVYLSRFYLAIATGLLHDETCTGHILCSILLNAPDLLRVDLQGVQVLLPHLLAALEIVLSKRQINVLKCPVSITDLRRAAIHLLVSMLCLPLHFQNLPIQDMTAGYQKKTQPPCDATPTHPAAQLTFLSLKPRITRLLLDALQIESDSYNVQILLGGVSLIIQDTEIAQSLGIAETISSHHIPITEDKELPNWTDFSARQRGRASTGGSSMISEAGSISMVDAETEDKLTFLKVSSESYDPATISGLFVQMTHLLCNKLVVTRSSKWKPDLHVTLASFEVLSGLAQLSMQLLDQTECKSTIHWLCDYVSYQANKPATHHSRDLHSMIVAAFHCIKTWVVAHPWLMDAEDCLQAVMEVVELGISGSKSKDARPEPGQEKKEPPLKGEKELKPVSFRVREAAEGLLTCIMEHLGCFPSPCGPAAMSSLLNEETLLEYSRNKKRLDKNDRQFRYFVIRDNTLILGLLEDSLEEKDRLPTVGAIIRAPTGRHVWTMELRQFSRKKHGLIEAHLTDPGRPMPRIDRATAPKPVTHRYFPPAVDNVPLTKADRSIPDLDDILDDKLYEVQDHMKTLMQKQAEHEAVEQCKVNREKARLRFPSDDTESIPLEPCEKFHASRLLLSHLGLLTVEGLKGNPENPSENSLFALDSTREGFRAALEALDTLPTRTQDTVFVFYIKNGQHEADEIIENEISSCKHSKLFVEFLLSLGWPVDVETHPGWTGNIHEAWTPADSATADDTRPKMSRDKSKLANSMSTITSSTSTMGIDGDVTHSSDEDSWLGRDRFLTCREQLDNEDGAQKDSLTQESSFTDSVTLVDSDTGADSVTREDSVTRADSVTGEDSVARDNSVTHEDSETSAQTVTQQPDNNSETSPEGHLDKELNQILYYADISREVAFVVPSLLPHYQRFRKMIVKAETSDEDNEESEELPRNRLRARSESMGSLEISSSSTSSMDMRAQLARQTSDAVGAFGSRMGKFSDGPVDTGKPIVKPSAHSTSSETNVIVAWLEHFPDHACFPIDDLLLEMDFGNTQGGSHRGLVDKDTVVIFIHILHNGLYRVHIRSTIRSPIGGPLLDGMVVSRRALGAMVRQTAMNIVHRRRLEIDTYSPPQVCRKLKIQDIVKKYRKEMSVPEFYVSLFGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID66</accession>
    <name>A0A6P8ID66_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pituitary tumor-transforming gene 1 protein-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563255.1">
        <property type="nucleotide sequence ID" value="XM_031707395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID66"/>
    <dbReference type="FunCoup" id="A0A6P8ID66">
        <property type="interactions" value="845"/>
    </dbReference>
    <dbReference type="GeneID" id="116298829"/>
    <dbReference type="KEGG" id="aten:116298829"/>
    <dbReference type="InParanoid" id="A0A6P8ID66"/>
    <dbReference type="OrthoDB" id="5829916at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052304">
        <property type="entry name" value="PTTG1IP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191:SF3">
        <property type="entry name" value="PITUITARY TUMOR-TRANSFORMING GENE PROTEIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191">
        <property type="entry name" value="PROTEIN CBG20567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028314260" evidence="4">
        <location>
            <begin position="28"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="5">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031563255.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20076" checksum="95EC572A23AC193E" modified="2020-12-02" version="1">MGLEVKILVALFVFTFTLLQFTSPVSAEFDCSKYTNTSCSSCTENSACYWCKSSTKCIHYPGWTKVVPHDCPHKDWYYGQCRISGFVLIILVPSLAAFALIFLCCCVYCCCCRRCKKWKQKRHDKEDIKLKRKRDEMQLLHSQRRNERQAKADNIRKKYGLLPSGGYERLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDB8</accession>
    <name>A0A6P8IDB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mammalian ependymin-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564127.1">
        <property type="nucleotide sequence ID" value="XM_031708267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDB8"/>
    <dbReference type="FunCoup" id="A0A6P8IDB8">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="GeneID" id="116299597"/>
    <dbReference type="KEGG" id="aten:116299597"/>
    <dbReference type="InParanoid" id="A0A6P8IDB8"/>
    <dbReference type="OrthoDB" id="6084362at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF5">
        <property type="entry name" value="EPENDYMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00317">
        <property type="entry name" value="EPENDYMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00026">
        <property type="entry name" value="EPEND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028219401" evidence="1">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564127.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24776" checksum="419C084A0BB1DC1B" modified="2020-12-02" version="1">MFKMLVCALVGLVAFAMIASAQRPQPCETPVQWEGNLLQSAPKKMNKTILAKMSYDAVNERVHIIDEDSRSGKLPSFEYIMLFRERRVYRITYNDKDEKICTAYRFYKPFRPATIPKNYYYATEEYIGSSLPGAGVLVKVFYGEYERRGRSGGYGISVTTEGCIPVQSWVYTEDYGVINFSFYNVVVGIEDPAMFIPPSNCRQGGSLKHDDLIHTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE44</accession>
    <name>A0A6P8IE44_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC116299489</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="26">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:46149"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dATP + H2O = 2'-deoxyadenosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:80084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:15194"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dTTP + H2O = thymidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80079"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:80080"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564010.1">
        <property type="nucleotide sequence ID" value="XM_031708150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IE44"/>
    <dbReference type="FunCoup" id="A0A6P8IE44">
        <property type="interactions" value="984"/>
    </dbReference>
    <dbReference type="GeneID" id="116299489"/>
    <dbReference type="KEGG" id="aten:116299489"/>
    <dbReference type="InParanoid" id="A0A6P8IE44"/>
    <dbReference type="OrthoDB" id="6020396at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Deoxynucleoside triphosphate triphosphohydrolase SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="15" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
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            <end position="276"/>
        </location>
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        <source>
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        <source>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    <sequence length="568" mass="65628" checksum="2A7B06DC8CA8AA77" modified="2020-12-02" version="1">MTNERKQYLFCSYENDVTGEVLPTLNRSSLQEFGIRDEEKISRIVALLGLFNKPSTSISQSVKRYHKVFNDPVHGHIEVHPLCIKIIDTPQFQRLRNIKQLGGCYFVFPGAAHNRFEHSIGTSYLAGKLVKSLQKRQQELDIKEKDVLSVIIAGLCHDLGHGPFSHMFDGQFIPAARPEIHWKHEEASVQMFDYLVDSNNLKQEFVKYDLDQQDLTFIKELIAGPRGDTPARTQDWPYFGREKCKSYLYEIVANKRTGIDVDKWDYFARDCHNLGIKNSFDHKRFIKMARVINVENKLQICVRDKEAGNIYDMFHTRFCLFIRAYQHKTSNIIETMMTEALLKANPYLLFEGKDGKKLKMSEAIDDMVAYSKVTDQVYYQILHGSDSRLEEAKKILQLVECRSLYKCIGQTILKKPREKEEAHDISKDIADSVPPDMASGTQLEPEDIIVHLITFDYGMKNQNPIDNLRFYTKENPSQAMRFRKDQVSRLLPESFAEQHMRIYCRKRDEDSIEKAKAAFFQWTLGQECTTPKFGDSVAELTPMKSTTADGQSGGVAQKLQFNDEIEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEE7</accession>
    <name>A0A6P8IEE7_ACTTE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299641</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_031708340.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="41"/>
            <end position="72"/>
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            <begin position="118"/>
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        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564200.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20184" checksum="EF62A245721BBBF4" modified="2020-12-02" version="1">MEQSRLPMRGKTKDAEAEALLKLLRQEQEFHNQVSIPEIQRKQPLPAIRSKASDSITEEHEGSGVFISQMRTTKDRDQEIPLNVDSQFLWNARGSLNRNNNDSHFTVASRPAYEWKKDSSNVNYSKFERQRRPSKNLPPLGPQQTSPRDRGERPSRPPPSSPKFWEDEKNEGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEQ7</accession>
    <name>A0A6P8IEQ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116299977</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299977</name>
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    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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        <lineage>
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            <taxon>Hexacorallia</taxon>
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            <authorList>
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            </authorList>
        </citation>
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        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1724"/>
            <end position="1744"/>
        </location>
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        <location>
            <begin position="1775"/>
            <end position="1844"/>
        </location>
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        <location>
            <begin position="952"/>
            <end position="986"/>
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    </feature>
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        <location>
            <begin position="1064"/>
            <end position="1121"/>
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            <begin position="1229"/>
            <end position="1334"/>
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        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
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        <location>
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            <end position="700"/>
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    </feature>
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            <begin position="773"/>
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        </location>
    </feature>
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        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="844"/>
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        </location>
    </feature>
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        <location>
            <begin position="855"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1792"/>
            <end position="1806"/>
        </location>
    </feature>
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        <location>
            <begin position="1814"/>
            <end position="1827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564575.1"/>
        </source>
    </evidence>
    <sequence length="1844" mass="210218" checksum="A05F2A392B5D79ED" modified="2020-12-02" version="1">MSDKERTNMKGSAAQDAVESNEGKNRREQLNEEAGSSKDDEKDTKTQIDFEMNKPWPPLLAEFTGKPRSYSDTSPRREIIKALTKGDIRSCTSYMHLPHIKHLTTLHDSTSSPHLHQSFSRMHLPTHDQDNDVPTISVIALAEARDKDGTDDVIYDDDDVKDLFVPLDDGEDSEEVREEAIYTWDREYGRTRSLSEPPDLNSLSGKKEVDGQRPRAMSLESAEKAKKPPARMQFQLTLEELAENQKETESESPTEQSELEPDQLDQDHLDKSSILVLAESGDFENDSSLTDSHVKDSDSQDEVLTRWTRYEGHPVKKPSFCADLSTIDENLGEGGGPPKEIIGGRSVLQLVDEVTKNVMSNENLVKGVQADIHFRAEVEAEIEDETFWTNKKSPRLGMRRVTLATASPAREAQNYATDIEREAFNKISQWKTDFAVKLEDVLSKGIEQKTEDKQQKPLVVNVPMNLSDIELRGLKGDLLSELRRKSNADARGTTAASKRTSPVVYHSRSPDAKKEVAQDANALSSNAHFENPPVQLDNIAITKDKIIELLQWHDRERERLLLEMKKMQVSREYLETPSASAQVVLESTGLESVFCSLQIIMDSIFKETILRLRGQLDSDSLEGKKSDERDVGRSEQQSRVGRFSPTKEKEKERQKKAKMAGKRTQGFAASQQAELEKQSTFAKKKTHESRILESMNDKNTGENTGTKTNQVKISSGTQDKPRSHQATHKKETGAKSSSLVHVHTASFAEHMCHQDTCAGMAEESSANSCECDSASDEMETTESEDEDDETTGISGTDLGEHYDSSEFLFDNLAGYRPEVLPGKSSTNDTDVIPTSSTSIPRVNSSSSPLTSRDSSVSDKAEKDSLSSEELDEEERGDELDFEESDACSEIADLLGVYQVYNASNEHDNEVLSRPHAPELMTYEEKDMKDKMNRQRIRLNGYKRIVHGFKTKNKRLKEEQLHLRRQIHELHDRCAKKEARITELKHEIEPAMKGYRKALEVGTNIIGMKEKQMLKMVEPEADYEQTVQEARWETYDGESKKYLKTIIRDKEKAIQELVSQHEKTFQDLTNKIYKVMSERDELKDENSRLKSISRAEEFERKKKKLEAQVVRLEKALKEALIKHEEKDRVNQSIISSLQKKLHETKTKHDEDSRLLYETQRSFEELKTSSSSTMEEQENEILTLKASVDAFQNLLMRVTEETSEASQRQNRPTPADHDFMKAALKEAVDAREDETRRHLQTQAKLDEANERMKKIDSIFKGTTPENMIENMKKQLESLQNENYKLKSHLQRKQESGSILIQVSELQTKLAQRDRELKQLKEEGIRQREEKNRLLTQLAELSRDRPAAGQGKIVEFTHEDSSGGNLSLAERCTRQWKEDTELEQQELDELRGKTSAFQSPTDYKNIIRLRKDVNDIKSAFEGFIRTQSRDRNIEQDEFKQKLELKAKRDMEKQESFYKQIIETKEKAYAEVLKEKDIMIQILNESKNLDQSKMVSEAVGTIIKDVIERGVSRKMEDLRKSIEMISRPPQSEIIHEVISDLLKMNQKATNRLEDCTERAWVNVKEDIDELKDFTFKMTDAIEKHFYSTHEHLLNSSIEEVIKHVKNESKGVRKSFLDGMQAHYERLVEEIKKQGTSGLARYDRLQSTIDGQNRSNMREFHQARRDVLLAAEAVSNSAEELYQIKKTLTQEFLPTEAGQMVKKEDEATQAAKKLNNPFEGGKTLEQLAEDYPSKASTSSTEEQHKGLSVTGKTTYSLNTTAELANLEGAILSDSFSSMNGEDPRHTYQHTPLFHTPPSRDSDGLSLRERLQQRKKARSARTSTEGVSPSEPYTTKIAPFWSRDKPSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFY1</accession>
    <name>A0A6P8IFY1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Octopamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565637.1">
        <property type="nucleotide sequence ID" value="XM_031709777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFY1"/>
    <dbReference type="FunCoup" id="A0A6P8IFY1">
        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="GeneID" id="116300821"/>
    <dbReference type="KEGG" id="aten:116300821"/>
    <dbReference type="InParanoid" id="A0A6P8IFY1"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565637.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39368" checksum="30633A15D7509189" modified="2020-12-02" version="1">MALSVRLALELANRSSLNICFESIVIGVIIFFTVVGNTFVCCAVWRNQRLRTISNMFVVALAISDSLMGILCMPFVFGTLIEGRWLFGDAFCRVHGFTGFTLALVSIHTMSLIAVNRFYCIVKPSKYQNLFRSSRTRIYILIVWLFAFVGSVPPFLLDDGGYSFHPGKGMCLYTFESNLVYTIFIEVAYIGCPLLLISFCYSSVFKEVYRTNKVFVPNQMAVDQLRVNVQETKITKTLAIVFLGFSICWLPASIIDTLGAFYGQPRFKREVYLTYTFMAYLSSLINPIIYGITSRGFRREYKAMLKGLTCHVLWKRNNFHHGQSTTFQESQMEAWQQSRPVEVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGU2</accession>
    <name>A0A6P8IGU2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand calcium-binding domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116301030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031565890.1">
        <property type="nucleotide sequence ID" value="XM_031710030.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IGU2">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="GeneID" id="116301030"/>
    <dbReference type="KEGG" id="aten:116301030"/>
    <dbReference type="InParanoid" id="A0A6P8IGU2"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000121">
        <property type="entry name" value="EF-hand calcium-binding domain-containing protein 6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000179">
        <property type="entry name" value="EF-hand calcium-binding domain-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015070">
        <property type="entry name" value="EF_hand_DJBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF2">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08976">
        <property type="entry name" value="EF-hand_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="560"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="689"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="798"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="906"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="942"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1388"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1501"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565890.1"/>
        </source>
    </evidence>
    <sequence length="1568" mass="182672" checksum="3DB448CED454B700" modified="2020-12-02" version="1">MAKVVVSPSVLNFADIRPVSRGLSFSPRPKSRLSTGNSRPGSGVKTRTEYTFKDTPRSHTFVDIPLPNHGRRSLSLSSLSSNGSKSPNPKLSFIEVESILREKVRVHFADIRQAFQTLDAEKNLTVTQSEFRRVLESFCCPMTEDQFNHILRKAVINRDGSVNYLEFLEKLHLRGGMADGMRWLDSLHKFNQAKTPVEKPFEDVENKIKTKISGQLQSVLKAFRLFDYNRDEQIQRHELRRVLENFCFKLTDQQFDRLWCKHDMTRNGSTLNYMDFLKRLGVDPQRKTKHRSTSKADQDTGQEKVKLMATNKRPHSSGSSREGSPTAMTVKDLELKLRKKMVENYSDMKRAFVAFDQRGDGFVTLSELKRVLNQFVFPMTAGLFDILMGRCGIKASHKIAYEQFLDKFQEPRSDGNGQTIPIRSNHKFNPIREAEDQPTTEDIWKFLFSKVSQSFSSIKEAFLVFDDNKDGRITKRDFRRILESFCFRMTEDQFRELMAKIDPHNKGSVSYLEFLEKFEPRETEEGHPWLMSDDTVKSISPPAVLAWSTVEDILRFKIMDNWKSIATAYINIDDNRDGSISRGELRKLLEKYCLPLSDEHYEMLWGRCDVNADNTVDFQEFLNKLGVDIISGDINGISTRIHDESEAKADFMKFDQHNRQEAAYDRALGLTGKKSADECMEILKEHISQRSPDIRKTFVKFDSDNDGKISRKEFRLVLDSLGLYMTDDQYRILSARLGFHKGKLTYRDFLENFQGRRSIGIEDRSPEYPKKKHNQPTPLEQSMTAEEVEAKLRTKLRDGYADLREAFQKIDFDKNGLITRKEFRRILDSLMFLLSDEEFDKLMDRLNMKKGDKLNYREFLKRFEHVEKIEEGHPWLYSNHFFNETKDLQYLSADEADRILKRKVVEQMDDITKAFLTFDRDGNGIVTKKELRTVLYRYQIPLTKVEFKKLWAKYDTDNNGYVDHREFIARLGGEFVPGDTHGPSTQITHGSHQEMQRFHDAQKAIHENATNNQAYAVSFLSALEVEQRLRDRFRDGYESLRKAFEAVDTNRDGYISRKELQQILFDFHYFLEDHQLNILLERCGLGSRNKLSYEKFLSAFEDQRHSGYGRVTLDTPKKKSSSTVVFENHETLSPEQAIAKLRGKISSNYDTIVKAFRAFDEIGMGYVTTKDLHQIIKAFCFVMTEKQFKALLKQITVNKDGLIYYEDFLESFQKSDVEASRKWLENLIPSPAKRQQSPIQKHGMTEEDVEKRVREVVMARFYSLAKAFTEQDTNQSGTVSQKTLRQILDRHVFRMNDDQFDHIWYLLPKDQNDLVEYREFLRMFTGRTDVTRASSATPPRTRERKLSRESLLSPMMTSPVFKNVSPETVTPPMSATDVERKLKSQVCRSWQQLQKTFRNADPNNTGRVDFQQFKDILYQHHMDLTHSELLALWKKHGSESSGRGGIVYKEFLRHFVLSSNAKPINQLARAKLQSTKIPSSPGFKSDQLVELMANMRSKVRENWKEMRRTFRAIDSKGTGTCSPAEFRQTLKRFTINLDDEEFFXIYSYYDKNMLGKISYNEFLRAHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH13</accession>
    <name>A0A6P8IH13_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinase</fullName>
            <ecNumber evidence="6">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031566137.1">
        <property type="nucleotide sequence ID" value="XM_031710277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH13"/>
    <dbReference type="FunCoup" id="A0A6P8IH13">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="GeneID" id="116301240"/>
    <dbReference type="KEGG" id="aten:116301240"/>
    <dbReference type="InParanoid" id="A0A6P8IH13"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.160:FF:000001">
        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF26">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566137.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="62427" checksum="88577010EDE88528" modified="2020-12-02" version="1">MEETDYTNEIVNKYTTSSSPNYFVSVTHQRLPDRLASLKAHVFSGNANSLPTSGPEQTNCFMGSKIFSSHGMTPPSNISLASRGNSKFGVYNAGAINTVSLKQEKNSTEKRTDLQATVKSNLCEENTHLDHKNSEYGSDVDQNNSNSIGNATNATGNVENNAESVKNVRRKPPLERKITPIVVVTPASDQTLDSSDMDSKIVGTSNGDVDGVYGLNDCIDSCSLSSVCSEDQKSEDDGILTDDDPSESDSASQVEENVEKRGVHWKKIRRMIQWSPFVQNFKKKYPWVQLAGHQGSFKAGENGTILKKTSDKEKDCLIILMKDILRPYVPEYRREVERNGEKYIEMQDLLQDFDNPCVMDCKMGVRTYLEEDLAKSKSKARKDLYQKMVEVDPNEPTETENKNKAITKPRYMQWRERLSSSATLGFRIEGIKKGDQKPNKDFKKTKTADDVAKVFTEYIENDPQIRTKYLKRLKAIRATLEASKFLKSHEVIGSSLLFVHDSKGRASVWMIDFGKTVPLPEGYTIDHRSEWKEGNHEDGYLRGLDTMIDIWTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJK5</accession>
    <name>A0A6P8IJK5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116301887</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116301887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566915.1">
        <property type="nucleotide sequence ID" value="XM_031711055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301887"/>
    <dbReference type="KEGG" id="aten:116301887"/>
    <dbReference type="InParanoid" id="A0A6P8IJK5"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF47">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027537134" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="146"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="291"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="490"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="679"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="809"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="952"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="1350"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="1474"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="162"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="296"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="684"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="692"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="814"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="822"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1145"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1313"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1361"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1427"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1479"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1487"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1554"/>
            <end position="1578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566915.1"/>
        </source>
    </evidence>
    <sequence length="1591" mass="180631" checksum="9D69234EF3531517" modified="2020-12-02" version="1">MKKAFLRLFLVVMVVCLSTSVGADDEIRCLDNEFQCANGKCIPISWWCDGDNDCTDSSDERSCNSNDSTVQPTDAAVNCLDNEFPCTDGKCIHRSWWCDGDEDCADASDEKFCNSNNLTQTTVTTTALPTTMTTTMVTTLKTQGPTVDPSCQRITSPIRNVCSRLGYTYTRLPNRFGHTNQDQIIRALGGWSEAIRKQCSXLLEDFLCRVYIPPCDRDETQTCRVICNSVKKSCRRVLRKLKIRWPSPLHCSKFPKKRCSRLSAEKPNTPPPKVKRPSIRXKSTRATEGIPKGPGCQKLTIQLCQGLQYNHTLYPNMLKHRTQAEASQEVYQFFPLIQIGCHKDFRMFLCSLYAPICTVMETPIPPCRSMCEQSKKGCEPLMNRYGFTWPEKLNCSNFPEFGNDVLCIGVSSNSKTVSTDIVSPTTRLTTQPTKKVPSPPPPNIASPKTQQPTKEVPSPPLPKAPETTARPKGINATAMSTTIVSHPKKTKTMLMTVQGVITSPNYPNPYPQGTKYNWIIQLSDSYKAIKITIEKLRLEEDRNCIYDYIIIKDKMLNQVGPRHCGTYRYPYEVLVRGNKAIINFVSDGSTSKAGFLIRYRGLNSVPSEEEEWIRKEWNFAALQKRKYALTQYELNKNGITAGYLVSFEIDQVKVKRVPKMKIPFVFFLVVMGTGWSLSTAGQSCERISHQMCQGLGYNYTQFPNRFNHRSQYQAMLEMHQFYPLVKVGCSSSLKXFLCSMYMPKCSKTLVPPCRSLCKQAKSGCGAMMKKLGISWPKKTKCSRFPDYENESCISSTENKSVSLGGIKATQGSRCEKITIPLCPGMSYNYTMYPNLLNHKTQVEAGLEVHQFYPLVKIKCSSELKKFLCTLYAPRCSDTLIPPCRSFCELSKSGCQKLMHRFGFTWPASLNCSLFPVEGGDRKCIAPKYGSDFATTTKPTTEISTISFGPKKFRTLLTKVQGVFTSPNYPKPYPQDIEINWTIELPDSYKLIKITMEKMRLEEDRNCLYDYIIIKDKMLNQVGPRHCGTYRYPYEVLVRGNKAIVNFVSDGSTSKAGFVIKYRGLVAKTQRPHAGCRAYIFDCLYKPHWQVTYLDIFKKRTIIGRETDCAKFYRTRNMKQPVLLLFLVVMDTGRSLTIGSTIGSNCERITIPMCQNIGYNYTMFPNIFNHRSQSEASVALRRYIPLVDWVCFKWLPKFLCSMFVPVCTNTSVIIPPCRSLCEQSKQACLQLVRTFGDDWPKNFDCANFPEEGLGKKCIAEKLTTKAVATTTSHTKLVIPTTRNPNVDSKCRKDEFQCQSYDSDQDMCIPKIWRCDGMNDCKDSIDERFCSTIGTTTRMPTTTKGPIVYSLCQGISSPIRNVCSRLGYTYTRLPNRFGHTNQDQIIRALGGWPEAIRKQCSPLLEDFLCRVYVPPCDKDETRTPCRSMCKKVKKSCRKTLKRIKMKWPASLRCGKLPKKRCHGAVHKNILPKKVKSSKDNCXNITLKMCQGIGYNYTKFPNMFSHQNQAEIAFEVYQYLPLIEIQCSSFLKRFLCSMYLPRCTTTGTTIPPCRSLCEHSKKGCEPLMKRYGFGWPAKFNCASFPKLGDEFCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJX9</accession>
    <name>A0A6P8IJX9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIV Tat-specific factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567020.1">
        <property type="nucleotide sequence ID" value="XM_031711160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJX9"/>
    <dbReference type="GeneID" id="116301984"/>
    <dbReference type="KEGG" id="aten:116301984"/>
    <dbReference type="InParanoid" id="A0A6P8IJX9"/>
    <dbReference type="OrthoDB" id="5982414at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567020.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22192" checksum="0A0DA6A0B37A5F3D" modified="2020-12-02" version="1">MADECAELKRDSTMTVTAKEGEAFLETKGKVDENAKTRGQQKEIEENKNDGEGTSPNKLSRTTTMTATAKEGNEFIDGEELGKTRAQTDNLQEKEEFEEEATEENGNEAENEEKPAVKRAGTMVVTAEEGAALLEGHDAEAGTRAEAKAVKEAIEESAEQNGQKEDEEKPDLKRKSTMDASVEEGQEFIKKTKESDEQEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJY0</accession>
    <name>A0A6P8IJY0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate system positive regulatory protein PHO81-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567099.1">
        <property type="nucleotide sequence ID" value="XM_031711239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJY0"/>
    <dbReference type="GeneID" id="116302046"/>
    <dbReference type="KEGG" id="aten:116302046"/>
    <dbReference type="InParanoid" id="A0A6P8IJY0"/>
    <dbReference type="OrthoDB" id="5990167at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567099.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33105" checksum="44B5F7138D3715F5" modified="2020-12-02" version="1">MEAWQSINKHKKDSTTESKESIDLRELSRLKSRMQARESTEKHEQHSTTESETSMKPFKSINPKAIKHDVNNSSSDAYEEGLLASDSSSGTSTSSSSRIVIKLSAERLISQKGLRKDYLKECYTKYNGFELQTSCLEFRVDLSELEHEFGKKVARQKTSISEYSFSHIRQSLLIGRSFTFSLMGRVYNEKLIYYAIIEVGADVNKTDKDGKTALFYALSNDHEKVAHALIESGADVNITDKDGKTALFYALSNDHEKVAHAMIEAGASVNKVDKDGKTALFYAKWNEKLVLMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL19</accession>
    <name>A0A6P8IL19_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein KTI12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567489.1">
        <property type="nucleotide sequence ID" value="XM_031711629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IL19"/>
    <dbReference type="FunCoup" id="A0A6P8IL19">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="GeneID" id="116302352"/>
    <dbReference type="KEGG" id="aten:116302352"/>
    <dbReference type="InParanoid" id="A0A6P8IL19"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000827">
        <property type="entry name" value="KTI12 chromatin-associated homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567489.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31509" checksum="A9115E8ED946B101" modified="2020-12-02" version="1">MPLVILTGFPCSGKTKRVSELKKYLEENKGQHVRVIDDEDGDVQRQSTYHDSKREKDARGLLKSAVERLISRENIIILDSLNYIKGYRYELYCVAKAHKTTHCLIHCDTPRETCAEWNGKMEDSYPEDIIDALIMRYEPPDARNRWDSPLFTIQVDDVLPAELIYDALINRVPHRPNQATQSQPLSATNFLYELDRITQDIVTAILNSQKTFVPGDKIAVPGTDQLIVLTRQVNMAELRRTRRQFITYTKTHPVDDTSKIANMFVQYLNNCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMK1</accession>
    <name>A0A6P8IMK1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116302457</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031567608.1">
        <property type="nucleotide sequence ID" value="XM_031711748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMK1"/>
    <dbReference type="GeneID" id="116302457"/>
    <dbReference type="KEGG" id="aten:116302457"/>
    <dbReference type="InParanoid" id="A0A6P8IMK1"/>
    <dbReference type="OrthoDB" id="5979893at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="2">
        <location>
            <begin position="72"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567608.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26693" checksum="A5864FBF1E457D53" modified="2020-12-02" version="1">MATNYYGSDCSSESEISSIYSEEEDGEIEDECHQHAETHESDDSYPRSESHELVGPYSSEPLADADWLSEYNEEISKIEKRNETLQERFDGVTPNSAWCRCGHCKKDLLQKPQECNCCHEIEGCLESLKSSEVLEELEVPPICVTLHPGFEPVCLNRWSLRSSCAKYRTIDGYKYRQTGSEEELLRATAYREFTQLVHGYQGGGSKRIPLPACAYHSIRKQFPSTDFCGYEDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMK7</accession>
    <name>A0A6P8IMK7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116302803</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031568042.1">
        <property type="nucleotide sequence ID" value="XM_031712182.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IMK7">
        <property type="interactions" value="1912"/>
    </dbReference>
    <dbReference type="GeneID" id="116302803"/>
    <dbReference type="KEGG" id="aten:116302803"/>
    <dbReference type="InParanoid" id="A0A6P8IMK7"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="9" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="15">
        <location>
            <begin position="81"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031568042.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30894" checksum="83710C02B6AB4579" modified="2020-12-02" version="1">MNHLLFSRFGTRKLFKQFLHLSSRKYCVSRTSLMAQKEILDATQAKLLEEKCILVDENDFVQGCXTKLECHLKKNILEFGMLHRAFSVFLFNSEGKLLLQQRAKEKITFPNYFTNTCCSHPLYNEEELEEQECLGVKRAAQRRLNYELGIPTSEIPLDKLKFLARIHYKASSDQKWGEHEMDYVLFVQKDVTLKPNLNEVQKWDYVTQSEVRQLLTEEGRDGKSRLVTPWFKLIAKNLLFKWWDNLDNLKAFEDHNTIHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMZ9</accession>
    <name>A0A6P8IMZ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116303100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568416.1">
        <property type="nucleotide sequence ID" value="XM_031712556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMZ9"/>
    <dbReference type="GeneID" id="116303100"/>
    <dbReference type="KEGG" id="aten:116303100"/>
    <dbReference type="InParanoid" id="A0A6P8IMZ9"/>
    <dbReference type="OrthoDB" id="6042339at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027582130" evidence="4">
        <location>
            <begin position="31"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="150"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031568416.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45661" checksum="2AB5B3220577B9BB" modified="2020-12-02" version="1">MNGMRSIIVLAIKVVATLQTAVSVAGSVNCDRIFNCNSSVISGQISSPRYPLPYPTNISYNWIIRSPPKTYISLLINKISIRLMPYCIDHLTVKYAGPVSYKYCYSWYVSSNLAFYSPNNEMNVTFTAGTGNNTEQQGFLAKFKILKAVCPKENLTSMSGILMSPNYYHSYYPGNLTCQWVIQVPQGYRILLTFSTVKLQNTNRCESDYILVMDGVGSSAHLMERICHERYVVHYYSSGNAMTVRFVSDLVFTNRGFYASYSATSPTPISTIMSSTAIVSGLPTYTVSPTPTLTPRQTLVVSPSKTTNVVPKQTPVPDFLPDYLVGTYQGLHGVPIQNYSFINRLKMKSKIACVLKCQQTLGCKAATFSYHGDDRGVCTMHDSSLQYKPEKNQQISGNMYYEQVRFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPY2</accession>
    <name>A0A6P8IPY2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116303528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568944.1">
        <property type="nucleotide sequence ID" value="XM_031713084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPY2"/>
    <dbReference type="GeneID" id="116303528"/>
    <dbReference type="KEGG" id="aten:116303528"/>
    <dbReference type="InParanoid" id="A0A6P8IPY2"/>
    <dbReference type="OrthoDB" id="5874059at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568944.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56832" checksum="4B2B9EB1F2252333" modified="2020-12-02" version="1">MPCRKCCSMAKSPVEDIRSDSDISVEREEILLPSNHNGRVSNYEQIKQRSPDENVVETKTKEDYGRRKIREVTNYYISHCTLHGFHYVFDTKSILRKILWLSILAAAGGFFFKEVKTSLYQYYQYPFTTMSTIEYPKKLPFPAITVCDFNDVRKSLLSSNASQMSNIIKASLKQLNNTLLYCALRHGYKRPSVFTIDDFDVFYSSEGQTCFTFNSGKNKSVIYGDNVGPKFGLEFILNVQQPPDNDVRESGFRFILHQQNDLPLTREGFRVSPGYVTYVDVHLAKEKNLPYPYITNCGGKSLKYFKDYSRSNCYLEMLTDHVIERCNCRSWFMPEVPNASTCSVNATLECVWPSWERFDGRSSYICPEDCSKTMYDAKLSSALFMPHKLLPLKQKHSYLTRPQNIPNDTKGIMDYIMENYVVVSLYFDELRLDIIEQKPSYGFYRLVGDVGGQLGLVLGASVITLLEVTDLFIMWVYFWLKGKAKNRSSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQT2</accession>
    <name>A0A6P8IQT2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116303804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569267.1">
        <property type="nucleotide sequence ID" value="XM_031713407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQT2"/>
    <dbReference type="FunCoup" id="A0A6P8IQT2">
        <property type="interactions" value="2162"/>
    </dbReference>
    <dbReference type="GeneID" id="116303804"/>
    <dbReference type="KEGG" id="aten:116303804"/>
    <dbReference type="InParanoid" id="A0A6P8IQT2"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031569267.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19328" checksum="A0003C1145EF6C1C" modified="2020-12-02" version="1">MFYHISLEHEILLHPRYFGPNLLQTVKQKLFTEVEGTCSGKYGFIIAVTTIDNIGVGHIQPGRGFVVYPVKYKAIVFRPFKGEVLDAVITQVNKLGLFTEIGPLSCFVSRHSIPPDMEFDPNSNPPCYKTKDEDVVYQQDDDIRLRIVGTRVDANDIFAIGSLMDDYLGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRV2</accession>
    <name>A0A6P8IRV2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031569612.1">
        <property type="nucleotide sequence ID" value="XM_031713752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304094"/>
    <dbReference type="KEGG" id="aten:116304094"/>
    <dbReference type="InParanoid" id="A0A6P8IRV2"/>
    <dbReference type="OrthoDB" id="5974900at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569612.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="62496" checksum="2C57843D5AA1A6AF" modified="2020-12-02" version="1">MSSKRIFQLVNKIHKQLDEEDDSNRKPFGGKQMILVGEFLQLRPVPNIFDAGDFMFRSKLFDVAVPXRFMLSKPLRQETADEPFVRXIQQLRLGKCSAESSLYLQSLNRPIVEENXIHIYFKKLSVEFHNFKVITEMPGELIQYECEDVGKVEKISCPASEKLXLKKNARVMLVWNLTDELKNGTPGTFLMVXNGLLEVDFGAKGKILLKRQTWEKRNLEGAVVGSRTQFPIVLFYASTCHKVQGLTLPAAVVHCTKEFVPGLIYVAVSRVRNEKQLQLCNFSPKQLLPPPRDAISVCDKNIAMXENHSCCTQQXLGLEFFQVSDRREELCEEHVDEPENLSSLSMDKYPDGIVCSFFEQEEETVVADLQXNVLLXLEDNENXMAVLPEELQIDELLEKKIVTDPLTDFAAKKNCAIRGILSNNSQIYLFARIQWIKIFNMFVNHLAKNPDELYTRKELTDATHFFYIELLNSADFRRELRSVFLVDELQEEHYSIGSTLCMDLFTMFVHLLAAKVVESHQLEQITIIRVDDMPPEGLAKIRHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISU8</accession>
    <name>A0A6P8ISU8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570266.1">
        <property type="nucleotide sequence ID" value="XM_031714406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304647"/>
    <dbReference type="KEGG" id="aten:116304647"/>
    <dbReference type="InParanoid" id="A0A6P8ISU8"/>
    <dbReference type="OrthoDB" id="10410686at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570266.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14150" checksum="AB61A963E51739AC" modified="2020-12-02" version="1">MPRKQKRNPFCGGSNKRKRRCSSTAFCHENAKSLSLSDKXSYYNREELLKRNDSASASAKKHLGRSEDEELNQASKEEEGEEERQNILLFSGLLSISPSPSSSPSSSPSSSPSSSPSSSPSSSPSSSAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT57</accession>
    <name>A0A6P8IT57_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G1/S-specific cyclin-E1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570376.1">
        <property type="nucleotide sequence ID" value="XM_031714516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT57"/>
    <dbReference type="FunCoup" id="A0A6P8IT57">
        <property type="interactions" value="1742"/>
    </dbReference>
    <dbReference type="GeneID" id="116304738"/>
    <dbReference type="KEGG" id="aten:116304738"/>
    <dbReference type="InParanoid" id="A0A6P8IT57"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20519">
        <property type="entry name" value="CYCLIN_CCNE_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20520">
        <property type="entry name" value="CYCLIN_CCNE_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="257"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570376.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50396" checksum="AC7E3A8E5AC6CE60" modified="2020-12-02" version="1">MASRSQKILSHRRSIEENIPKKKRKTKDTSISKTTSKRPRTTSRSKSNITMTETLCNTVGSISSFSKIEKGISSTDRILKDRTLATNVQSTIHKTDKHTSSYTFSNFFVPVVRKLTPLPELNWADSTELWNYMLEKYKKYAKDPLYLRMHKQLQPRMRSILLDWLIEVCEVYRLHRETFSLAVDFIDRYLSTKQDIPKQRLQLIGTTALFIASKIEEIYPPKLSEFAYVTDGACTESEILQQELIMLKQLNWNLCPVTCNTWLNIYLQLYWLNTMMKSDPKMISCNYNFVYPEYSQQDFLRVAQLLDLCCLDIGSLQFSYSIIASSALYHMIPVNIEEITGHKWEELFPCIQWMSSFSAVIRDMGNPVLKTFEHVKSEDSHNIQTHINNLTLLEKAQTRQCVPDTTSSSRSESPPVVVQHFAPLTPPSSTKKAQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU59</accession>
    <name>A0A6P8IU59_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Octopamine receptor Oamb-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116305093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570786.1">
        <property type="nucleotide sequence ID" value="XM_031714926.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031570787.1">
        <property type="nucleotide sequence ID" value="XM_031714927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IU59"/>
    <dbReference type="GeneID" id="116305093"/>
    <dbReference type="KEGG" id="aten:116305093"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="28"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031570786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031570787.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36954" checksum="DF66916ECC4031DF" modified="2020-12-02" version="1">MFYEGYWFETTLSSTIVYFFISFVTVAGNVLVFASFIRDPYKQLRTLQNYFIVNLAVSDLAMGCLAETLLAATYWENTSDVFYAHYLCAIVSGVSSLLNMAALSVYRYFVIRNPFTYHGIITKKRIIITIICIWVYTLHFVALTLAGWKSPWYQIYLYGFGCTLPSVLIILTYFGVFLAIRAHTKQLKTTTDSKSKALQNAITREKSTTKTMLIILGVFITFWVPFLIIDVIMVQCYPCRSIHSVHIARDVALTFTYFSSGINPLLYAWRVQQFRKAFIRVLGLSNLRCVKRQKNRIQVAEAKTVRLQTLAILPENSAWIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVG5</accession>
    <name>A0A6P8IVG5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: protein dispatched homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116304521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dispatched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570128.1">
        <property type="nucleotide sequence ID" value="XM_031714268.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IVG5">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="GeneID" id="116304521"/>
    <dbReference type="KEGG" id="aten:116304521"/>
    <dbReference type="InParanoid" id="A0A6P8IVG5"/>
    <dbReference type="OrthoDB" id="193905at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF3">
        <property type="entry name" value="PROTEIN DISPATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="862"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="963"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="412"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1054"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1056"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031570128.1"/>
        </source>
    </evidence>
    <sequence length="1078" mass="123441" checksum="98713BC07B6A6F02" modified="2020-12-02" version="1">MDCPEASPSINLDRILTKNHKRQSGVNEGNTGRYVYSVFVAEHPFLLFFSTLFVIFICSLCSFVPAFNAPEFPDFSTPVMGFEARGSQINGRWRTRLFLTIAIGRKMFSPIPPMKAIXDTALTHSVVENCPSINFTIIQSRATREMRSVPHKKRFRSRRDKHGNAAALQMCDSPNVYMKSRLDYKTIYTSSDGMGLMTAIKLRAVCRLEEKVIKKFAEYERKCYKRNITRSGXTKEECCPSWSIGNYVASIRGKASCDDIDDDDVLSIAKRLQKCSDMFNNGSLKENCWNFAYGVPYPYCEDIPVDCIQYNAVFNILYYLSDKDFHGIQGGXHLKYTQVLTPRHEDLRFSRKIYYKYIEDGKPVEDGSIQLIGSDFHSFKFNMFNTQLIADLVYPLIALMVILVIMWFYTESLLLTILLSVSVVSALILAYFVYMIIFGLDFFPFLNVTTLIFLVGIGADDAFVYTDVWRQSKREHPEASLKTITSYTLKHASLSMFVTSLTTAAAFMANFSSEITTIKLFGLYAGVAILAKFSLMITWFPAVCVIHEQYCVKNMCGPSFKNTGQDWLSRCRTSYENTFTRFSRYMFNEFLPQLVIRCRFFWISLFSCLSAAGLFVIIGFPGFQFPTSSDFQMFASSHPLEKYDLYLKDKFRFEISPSQESATFPIDIFWGIQPDDYGDQLNPYSYGKFGWDQDFDIASPKSQKWLLDFCKRLRSQDFYARKLGSEKKCFIEVYYNQTCNDPLVPKLCYYPCCKNSTFPYSKDILNFCAITNAYRRKILRFKVQDSTIGSFIYDPQGNLKGIWLRIMSNVRLSRAYKPAHRFWERIETWIQQEMKNAPPGMNKGWFTSNLEFYNLQQSLSRGTLLSLSIAIASAFAVMLLTTMNVFVSLYAILTIIGIISVTIGSLVLSGWKLNILESITMSVAVGVSIDFSMHFGVAYCLASEKQSRTSRVRYSLSRMGSAISMAAVTTFLAGAFMMPSAVLSYIQMGHFLMLVMTVSWFFSVFFFQSLCAVAGPQGDTGQLSFKKMKKWLKLSEKNNEKKKKKSFWEVKMGVTKNEKQRDQKEMEKESSSLVDEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVM7</accession>
    <name>A0A6P8IVM7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="3 16">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116304564</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Golgi apparatus membrane</location>
            <topology evidence="16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="3 16"/>
    <dbReference type="RefSeq" id="XP_031570183.1">
        <property type="nucleotide sequence ID" value="XM_031714323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVM7"/>
    <dbReference type="FunCoup" id="A0A6P8IVM7">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="GeneID" id="116304564"/>
    <dbReference type="KEGG" id="aten:116304564"/>
    <dbReference type="InParanoid" id="A0A6P8IVM7"/>
    <dbReference type="OrthoDB" id="675023at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000044">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF65">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucuronate</name>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031570183.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40643" checksum="7249926F42208026" modified="2020-12-02" version="1">MFVRGIFKYVILLCGFTIVVLLTRIIENRIENENFTAVFSLSEEDEYLSKTTHPNTERSNQDIKTHNKNTKTNINILHAHQINKRNTISSSRSTDLPTIYAITPTYKRFLQKAELTRVANTFRHVKNFHWIVVEDSRIKTNLVHNFLENCGLKYTHLNIRTPKPLRRSRKQPRWSTSRGVEQRNLGLAWIRIHVSLNKTKGVVYFADDDNTYDVRLFEEMRFIKRVGIWPVAFTGAARWSGPVCKNGKVIGFHNNWKPWRSFPIDMAGFAINVKLLIKVFPNASFDPEVRPGLMETSFLEQITTVGELEGKADDCMKVYVWHTRTETPVININGERQLIKLGVPSNLLVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVT5</accession>
    <name>A0A6P8IVT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116305599</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116305599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031571406.1">
        <property type="nucleotide sequence ID" value="XM_031715546.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IVT5">
        <property type="interactions" value="2441"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116305599"/>
    <dbReference type="InParanoid" id="A0A6P8IVT5"/>
    <dbReference type="OrthoDB" id="5956183at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="11">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031571406.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="62406" checksum="08115C89C948A47D" modified="2020-12-02" version="1">MPSHCCVPECTFKGHRDAEGNKISFFNFPKDAILRKKWIHLIRRVPGKDFQLTSRTKVCSRHFKTTDMKKSLNGIVKLKPGSIPSKFAWSVQSPRKRKSPTNRXTPPHPSTAIEPDLEASTSESVDHICEPTVEELLIEAKIDKEKLEKQISDIQSQFIELQIENRRLLETNKKIMAELQSERGDALETVFYREAEKEELEKKCQLLENKLSDAETKLFKLDNFKSDENIAFYTGLPNYKTFLAIFKFLNTGDKGENVRYYSTKNKDVTADFYENQEDEEEDELSENTTKTKSGRPRKLTVIDEFFLALCRLRRGFAELHLAHLFGVSQSTVSRLFGTYINYMYLKFAQINIWPSREIVNKQIPEIFKEKYPKTRVIIDCTEIRCQMPSGLLLNSELFSSYKNHVTFKALIGIAPNGAITFISQLYTGSISDREIVTRSGLLDLKFDDGDSVMADKGFTIGDILPLGVTINYPPFLGEEAQMSKEDVIETQQIASVRIHIERAINLIKNYHIWDGEVPLSLIGLVNQMWTVCAFLCNARNPLISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYP3</accession>
    <name>A0A6P8IYP3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116306690</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572636.1">
        <property type="nucleotide sequence ID" value="XM_031716776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306690"/>
    <dbReference type="KEGG" id="aten:116306690"/>
    <dbReference type="InParanoid" id="A0A6P8IYP3"/>
    <dbReference type="OrthoDB" id="6016713at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572636.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23688" checksum="37E6E9FD295A2319" modified="2020-12-02" version="1">MLILCEFVLRNGTAYFRELSDHLEETTGSRYSAQSLCRLLKRCGYSRKGIHRVALQKRIELTEEYRRDTSVFRPEELIFVDEKFCDRRISRNYGYSPXGQRATXSYANPHGPRLTVIAAISYQGLFGLKISKKRFDARKFRAFIXNDLVPILQPYXGVNSNSVVVMAHHVREIRQMIENAGALLFYLPSYSPELNPIEEVFANVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZH8</accession>
    <name>A0A6P8IZH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116306677 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572619.1">
        <property type="nucleotide sequence ID" value="XM_031716759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZH8"/>
    <dbReference type="GeneID" id="116306677"/>
    <dbReference type="KEGG" id="aten:116306677"/>
    <dbReference type="InParanoid" id="A0A6P8IZH8"/>
    <dbReference type="OrthoDB" id="5962129at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572619.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="77686" checksum="584B6B39A25E76A7" modified="2020-12-02" version="1">MVKPELKGEKPILLPSESEDSIDAHDQNVELVVCDKEDGAVTVTFDETRARKGPRVCVFVGLFVFVLVVGFLAVYLIGRTHGKDRNHGLPTNMKDDIARVPTLEPELGNLSKYWQEHSWETRDELFQLGDAIGSNDIIGLRPIYRKDLPKEYIAYWEVKMNGKTGEKYLIISAAKETGDHRLVQEGALPSPIDIMTDYARLRSHSCHRVYRLTPDGLMTCEDNNLKRTVAATRDVETNAEFQQRQWKKLDRQVKKALPRFKKAWRDLARRVTKLPEWRRFKWLSMKSGKMPTEKSSKHDSSSRHEHDDDYDDNYVTEEDDEMEAELAVRPGEVLKVPLIGKSCQVRIKFSGFGQIKRHGRKRKTWLNRWQKRLCRVLSDPCEGSDMTRVKWRYIKNTKMGDRYIGLQIVSSSQYVRKQLQGQEIRFRIEVEMNNRKTLVVNYGIMLRHSRRGRSVEGGDVNHYSIPHRHLFPDYKQHQHGLCMTGSGAVAWGMVLGYMDNLAYRVPESGYPKNILGLFPGTSPAPMTTTKYAQSAIENLFEKLESRCSLEDKAALTSPAKMERIGKWLNHTVLQLIIENDSLNKETATARAVQLLQKRVPVIISKERGDSLYHHYSVATRLRQRIHRYRNCKVTCSSWRTLVENEAYVHLGVGKYGNKWENIDTHFMAAILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZI8</accession>
    <name>A0A6P8IZI8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L13a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572587.1">
        <property type="nucleotide sequence ID" value="XM_031716727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZI8"/>
    <dbReference type="FunCoup" id="A0A6P8IZI8">
        <property type="interactions" value="1321"/>
    </dbReference>
    <dbReference type="GeneID" id="116306645"/>
    <dbReference type="KEGG" id="aten:116306645"/>
    <dbReference type="InParanoid" id="A0A6P8IZI8"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572587.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23208" checksum="3E0F6C71678D45E3" modified="2020-12-02" version="1">MGFEKQIVIDASGHLLGRLASTIAKSILNGQRVVVVRCESICISGNFYRNKLKYLDFLRKRTNTKPSHGPFHFRAPSRILWRTVRGMIPHKSKRGTEAMNRMKVFDGIPSPYDKIKRMVVPSALRVVRLKPGRKYCVLGRLSHEVGWKYQDILSTLEEKRKAKALVYHEHKTKIQKLKQKAEETKAQELKSVNEVIESYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0G3</accession>
    <name>A0A6P8J0G3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sphingosine 1-phosphate receptor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116307295</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573326.1">
        <property type="nucleotide sequence ID" value="XM_031717466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0G3"/>
    <dbReference type="FunCoup" id="A0A6P8J0G3">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="GeneID" id="116307295"/>
    <dbReference type="KEGG" id="aten:116307295"/>
    <dbReference type="InParanoid" id="A0A6P8J0G3"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027545437" evidence="13">
        <location>
            <begin position="37"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="275"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031573326.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="65486" checksum="2B0AE4C4FAF2A091" modified="2020-12-02" version="1">MQFWSYIVSCLSAQMGHQVHWWLLFIVLLCIHEVDAVRVLLHACLNGGVEDDVQQVIVQDLDLEHLPHPKSSVCSLEIFNSNTSSIQDGLFVDFTGSLTLSLYNNNIHNISANAFLGLTALRTLNLSMNPIKEWQTSKLISHVPNLTTLDLTGTSPWLPDYGILRVKQLRTVQGVSWGQHCWNCSLIKSNTSSQLKLYTEGSTRYIKGYACRTITTTASKIVQGFANQGFLGQCVIENPKCSQSEMKEFLKAPCRDTTLSVMYLQFVLGPLAIALNLIVIITTICSKRLHNNLDMVLVCNIGVGDLFNGVYSVLIISIHTFKTFDQMLTFAHNYCASIGFFWVLGICLAVGFAFVLTIERYKCVVRTQPRHSRMSPTTLLVASAICWLWALAATILPVFGVGSYSLNTYCISVFAVKSNPLQFYYSTTVAGLSGLLYLATIPIYIKMYLFVRRSSKNMRIRADIELAKRVFSLVSTNMLFFLLPVIISLIFASVNRETSAISREVSEVLNSAFPLLCLTLNSVFNPLLYAFRSKLFRTEFVRMLSSRCSFNGSGHKTRPTSLKRYPARVAYVVRSPNNSTSLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0H1</accession>
    <name>A0A6P8J0H1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrin alpha-D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571673.1">
        <property type="nucleotide sequence ID" value="XM_031715813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0H1"/>
    <dbReference type="GeneID" id="116305840"/>
    <dbReference type="KEGG" id="aten:116305840"/>
    <dbReference type="InParanoid" id="A0A6P8J0H1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF84">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028400912" evidence="1">
        <location>
            <begin position="21"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="76"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571673.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32730" checksum="D350B938F791F728" modified="2020-12-02" version="1">MAKAAIIFVLMALVLPFCWSGIWERKPWQNYGRNYLDRYQYIPKKQVTARKLMKYFLNRAPQRLTKRSSSEGVFYDVVFVLDSSGSVGSKEFKNALLALQTLITRAKNDTLYAGITFSTTANITYNFTYPIQAMKNLGKTVYIPGRTNTQEALDKCRTELFFKRESGYRRLSYKRILIVTDGQSNIEKPKTLYNAFRLKNMGIEIFVIAIGKYLKGIAEIVGLASSTDAHLYRVRNMKDLLDIVHLIPPWEFLRQQQKTWLENMFEDMDDEFKYIKKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J158</accession>
    <name>A0A6P8J158_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116307493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031573621.1">
        <property type="nucleotide sequence ID" value="XM_031717761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J158"/>
    <dbReference type="GeneID" id="116307493"/>
    <dbReference type="KEGG" id="aten:116307493"/>
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    <dbReference type="OrthoDB" id="3633556at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF32">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="131"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF00501"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031573621.1"/>
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    </evidence>
    <sequence length="374" mass="41272" checksum="D1F08C859B54B357" modified="2020-12-02" version="1">MAQLVSVKKIESNGGLHDKVSLNNINMSEGNPKNPVENSAIQHKEQNGIVTHPQTEPQTNGNGIKNDCSRHENNDGPKTIQHGASDDESIPIQLEPAESFWTTKADSAIKIRIGDDENTKLAPTTVIQLLENTVKVAANRIALGVKRDGKWRIWTYSEYYEEVRSAAKSFIELGLEPSHGVGIIGFNAPEWLISDLGAICAGGLAVGIYTTNSPEACHFVASDSKCNIIVVENKIQLDKILKVWDKLPHLKAIVQYTGTIEEKRPNVYDWNEFLQAGKNISEATLQDTINGLKPNKCCTLIYTSGTTGNPKGVMLSHDNMTWTAKMACKHVNAGQKGEEHIVSYLPLSHIAAQVSWYPKNWRLLKGSRYVDDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J214</accession>
    <name>A0A6P8J214_ACTTE</name>
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        <submittedName>
            <fullName evidence="3">SCO-spondin-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC116306262</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028204494" evidence="1">
        <location>
            <begin position="28"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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        <source>
            <dbReference type="RefSeq" id="XP_031572148.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28187" checksum="3CEF5EAE60018ED8" modified="2020-12-02" version="1">MDLFHCSTWNSMHILLLIQWFSVTSVCSPNSISPRRSKSNLTSGVLKCPNVKGSSDCKMSCMRDEHCDNYGDLLRCCPVGPGHVCKAECKEPVLSQGGGSGICYDFKLDRQYVSGDLFVRDGVCCRCERDGRANCTAIGSCNQGCYYGSTYYNDGVAISRSSCRNCTCENGTVFCKWNTNCTQEKCKYKGKVYTLEHIIRLDNGCKECVCQYRGWSCTAITCNAARSSSTSVGISRVKACVFAILIVNMQYLLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2M7</accession>
    <name>A0A6P8J2M7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116308030</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116308030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="2">Tentacle</tissue>
        </source>
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        <property type="component" value="Unplaced"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CCDC117"/>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031574241.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44430" checksum="9C78EB6004D99A66" modified="2020-12-02" version="1">MDNNNSLPYGAISSINSQHNLLPNQRFHTPPQNTLAGNDLQDPIAVARNVHQIGSVPRDRVRFTYSQQENGRNSLSGSDRLHLXFPNQGINGVTGMTELSTSSTGSPNSLINHQAINDPLLNSNESNIGTGTGNVFGVNRYFQTPWSMNGITHAERPNTNSYRPLEHATGRPMSQLPTLTEQNPIQSGSCSXHTAISKGFXNQNSKKHLGIKRRVSRDESEDGLPRPASKLLLTEEKMAAKMHNLSINNDHCYHITCLPTQLAIMESNSISPTMSESVSEDEVKEDDNNNMESANSSGFVLAPGIKEMLSKSNNILPQSILDQMSKPCLAVIPWKPPDELVTNISFNFSNKTDDEKMAEKDSKENNNDKAHQLFTFGNYSVDHTEVIDDCSTFDLDDDDMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3B2</accession>
    <name>A0A6P8J3B2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA-processing protein fyv7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572503.1">
        <property type="nucleotide sequence ID" value="XM_031716643.1"/>
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    <dbReference type="FunCoup" id="A0A6P8J3B2">
        <property type="interactions" value="1177"/>
    </dbReference>
    <dbReference type="GeneID" id="116306568"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15657:SF1">
        <property type="entry name" value="THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01854">
        <property type="entry name" value="BR22PROTEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572503.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23933" checksum="87169E83432241D2" modified="2020-12-02" version="1">MAADEREKSTKKKPGSKWRKRANIAGIGSREKGQGFAQVRRTKAIREYKKLLRKTRKEHQTSAXVQKVYESELNKNSGREEGERASSQRIEHTDDNKNSKELKDKIFIKKTEDSSSSAPTGRNRKRVNTQTRFSTAEKEYKRKKFDIEQNKKEREEQKEKRIQELQRSVKRRRQTNQQLMKRTRRGQPIMANQINYLLSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3S6</accession>
    <name>A0A6P8J3S6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574254.1">
        <property type="nucleotide sequence ID" value="XM_031718394.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308043"/>
    <dbReference type="KEGG" id="aten:116308043"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="637"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574254.1"/>
        </source>
    </evidence>
    <sequence length="924" mass="104000" checksum="318D7D86EE80F842" modified="2020-12-02" version="1">MNSEKLALDKKIQDCCTSCRFPEALKYCEESLKKARETEDKIWEMQAYSNLAAVLNSLSRFHEAIDYSQKCLVIANEIQDKKMMARVHDNLANAFQRIGKSEESIKHCKELLEIANDSSDKKGQQQAYLLFGNAYKSLGKYKTSMDYYDSCLEIAKEIGDKLMQGRAYGNIGVLSKAQGNYQKAIENHKKYRDIAIETGNLQGEANANGNLGVAYRLLGKYDQAIQCHEKNISIARKIGDRKGEGNAIGSKGNAYKALGKYQEAIDCYKEGLEIAKEIKSKDSELNAYGQLGSVYQLIGEFKKANKCNKQCLEIAKHIGDKNSEAKAYGQLGAGYQGSGEYDEAIKHYQKFFNIAKEIGDRNGQMAALGDLGDAYRLSGMYEKSIDSTQKCLDLAKEMDDKSGQAKACFSFGHCYYVLSYKQNGKWNGKDRHALLRESEKYLKESLQNYEWIFDHLEKGQDQFKISIVDTFVHAYKLLTTVYIKMQQNEAALLTCDRGRARALRDLLATKYEMEMDTGPRRRLQYSDVESIMSNPSSCILFFGMVMRPHKKIDNNVIEGGAATWLITHDNPLCMKHDSEFDKFGFSSQKPANEYVNDLVNQAFTEMEVRRAVDCEDRSLDTNLDIRCIEDVKYDGEPALEKLFDMYVSPIQDKLATQEEIVIIPDGGLFTVPFAALKDPKTKSYFFKDKRIRLAPSLTTLKILRESSVDSKRTTGALIVGDPEVGKVMFQDGEKHFCRLPGAKSEAEMIAKMLDENAITGSRATKQIIKQRLQEEVAVVHFAAHGSTEGEIALTPDTSVVDGSIPQEKDYLLTMKEVQEIGIKAHLVVLSCCHSGRGEIKAEGVIGMSRAFLAAGARAVVGSLWAIADQATMEFMKRFYTHLXERESASSSLLKAMQDMRNIREYEDPRFWAPFFLIGDDVTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5C7</accession>
    <name>A0A6P8J5C7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuropeptide FF receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116308934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575316.1">
        <property type="nucleotide sequence ID" value="XM_031719456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5C7"/>
    <dbReference type="FunCoup" id="A0A6P8J5C7">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="GeneID" id="116308934"/>
    <dbReference type="KEGG" id="aten:116308934"/>
    <dbReference type="InParanoid" id="A0A6P8J5C7"/>
    <dbReference type="OrthoDB" id="5950491at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004977">
        <property type="term" value="F:melanocortin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000368">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001671">
        <property type="entry name" value="Melcrt_ACTH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00534">
        <property type="entry name" value="MCRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031575316.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36167" checksum="0092749FCD65A4AD" modified="2020-12-02" version="1">MAYPENKSFETGMYVSLSTLVFINLIGNTLVILVILTNRKMKSPMNYLLANLAVADIMVGAFIVPPLISKQFFTHPEGIAGAIACKVLTGGSLTWVGSAASAFSLVAISFERYFAVIHPHSTKLRLTFRKVKRVVKGSWTFALVINLPSFATLAYDKNINLCVEEWPEQQIGSAYGTLWFLAVGVLPITIMFGLYSRVVYTLWFKRSKNQVPATQLSILKSRKRLTKMIFTVSIIYAICWLPDLTIYLLHLYNVTFGYAGLPNVIGVILVTCNSAVNPFVYTFQSEKFRRHLKQLVLCRKYRRNRVANAILTIFLETGATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5U3</accession>
    <name>A0A6P8J5U3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116308750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116308750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575092.1">
        <property type="nucleotide sequence ID" value="XM_031719232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5U3"/>
    <dbReference type="GeneID" id="116308750"/>
    <dbReference type="KEGG" id="aten:116308750"/>
    <dbReference type="InParanoid" id="A0A6P8J5U3"/>
    <dbReference type="OrthoDB" id="10031171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34488">
        <property type="entry name" value="SI:CH211-245H14.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34488:SF1">
        <property type="entry name" value="SI:CH211-245H14.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031575092.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31574" checksum="89A2351CE7D887F1" modified="2020-12-02" version="1">MYEFILHTSSNQLYHWTGFGRFFQFLEFSTIYTYPEVYELLYNTRATVISLPAVIWDCLNKRTFKFLLLGGIRLLKDASRKISCFRFFCSWRKSVPPCVVIIFFYFWLKRQQYCRKFAILSKESDQSRVNNNIKDIEKHILSRLQQDLRNEHIQLEEKSWIQDLDDGERPVFVFCVISSRIGTDIENAMRGVHDNSPVILVLLHCALSILLRDRDLFDDEELLDPTMKNRMTGIAHFAFSDREGLYDCKQNRYGFKKLGCTINVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J846</accession>
    <name>A0A6P8J846_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031573240.1">
        <property type="nucleotide sequence ID" value="XM_031717380.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307224"/>
    <dbReference type="KEGG" id="aten:116307224"/>
    <dbReference type="InParanoid" id="A0A6P8J846"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="102"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573240.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37579" checksum="87761377EFD1D5A7" modified="2020-12-02" version="1">MPNSSSPKNLSSKQIPIISATILLVGTTTLFFVFVCPPLISKYSLGIAVYEGLLAFFVLANFAHATFXDPGIVPRAPSNPEYEDDFKAPLYKNIDINGITVRMKWCETCRFYRPPRCSHCSICNNCIEKFDHHCPWVDNCIGKRNYRYFFLFVLSLSIHLTSVFALSLVNVLDMNSDIRKPAVIISIIIMVICCLAAIPVFGLTFFHIGLVGMGRTTNEQVTGKFRSGHNPFDKGCKKNCSSVLCISQYPXYLGFKEKYQKRQKKKARSNKKTTGPEETELSDVRIQVARDGPKNXSGARALRPESFVTAINSTPQSTYISAANGRVFRPINEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JD93</accession>
    <name>A0A6P8JD93_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein with KRAB and SCAN domains 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116308247</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574490.1">
        <property type="nucleotide sequence ID" value="XM_031718630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308247"/>
    <dbReference type="KEGG" id="aten:116308247"/>
    <dbReference type="InParanoid" id="A0A6P8JD93"/>
    <dbReference type="OrthoDB" id="5956669at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="439"/>
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        <location>
            <begin position="440"/>
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        <location>
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            <end position="625"/>
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        <location>
            <begin position="160"/>
            <end position="183"/>
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            <end position="230"/>
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        <location>
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        </location>
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            <end position="704"/>
        </location>
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        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
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        </source>
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    <sequence length="835" mass="95406" checksum="F5FDFBE1BA640CED" modified="2020-12-02" version="1">MASTAVGPSAVAHRPDQEENCTVSQQTVYNNTCNXILLFHNNNLILKAERGVTLGLIKLIYSSDDNNSGIILGVKPRLNKQVPCLVTFDSTSLTYDAYDLIIKDFRSGNDINNDMAGNAEQPSSNFLQCFSVGERAANSMCISRQELPPSAAQYKDLELTETDDKECNSYEDHSTDDSLERSRSNDMFLENSTTQEDSFKSVELQDIAQRDLNLSERETSENYPDEENDCEEELNDCEEENENDESVQFNPEDFNFDIKSVIPTKTDKGLRWPCNRCXKDYCSASHLKRHWILHTDFKPYKCSLCIKRFPFHWDLKRHMTKHTGNKRYKCPHCTKSFNTQKELKCHNWLHTGQKEYKCHICHHEISSSGNLKIHMRKHTGEKPYKCEYCPKAFYMLGHYQYHVRRHTGEKPYKCDVCDMAFSYSVNLKEHKNIHTGTRPYSCPTCDKRFTHRSTMKQHILTHSGQRPYKCHXCSKNFIQSSNYRMHLLTHKDKQDRAQKCDLCGKELLSRRGVKKHRQRCAQTLIDRANGVTSKKNKPKTNTKERYECGICSKLFTYRANYEAHCKLPHPIKKKXRERKTQVAKQSKSSISRSHNKVKCPICGKQFLYMKCIKRHLQKRHSGIEVGTRSSNVVTSPSEKTEALKDVQTLPTVHIQPMGELSSSNVTLIYVPSASARSSSXAKSSSMLTVLPKPRQESETGRSEHSAVVVDSESVGRYPLSKQSNNDKTCKGAETGSQAITALKILSAKIGIEDQFQALSRRKDEQRPPISKHLTALEQLSKRVGVVEEIPVTIETAXEPNEQNTDVSIMKDQANSQNGYEIERKGLNETKINTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JE39</accession>
    <name>A0A6P8JE39_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable S-adenosylmethionine-dependent methyltransferase At5g37990</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031718855.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574715.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43373" checksum="FE3B3DFE15045916" modified="2020-12-02" version="1">MEEKKAFVPHSHLPYGKVGSGFYSTRSIANRQVVKTATPLVLRELDAMALEKQSVVTLVDYGTADGGTSTSLIYACVKAIREKYGAKLPINVIYEDQPVNDFTSVFLRTQGLIPGPRSYLLDFPNVFVMASGTNFYDQCFPNDSVTLGFSSNCAHWLRDKPCDMTGTTFHLFITVPEEKEKFVAQAEKDWELYLTKRAAELRPGGSMALAELAVDQNDQFAGHTKDAKHCCHTVLSTLWKSLSDEGIITKDEVAKTNFILYFRRVDEFKKPFKCPDSPVVKAGLELVSIETKIVPCAYKEKWIKEKGDAKEHAKKYVESIRAWSNSTFLSGLSDSRSAEEKSKIVDELYHRYEAEVAKCPEDYGSAYVNAYLVIRKRLRTESTGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JGD9</accession>
    <name>A0A6P8JGD9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Poly(U)-binding-splicing factor PUF60-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575345.1">
        <property type="nucleotide sequence ID" value="XM_031719485.1"/>
    </dbReference>
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        <property type="interactions" value="2203"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12370">
        <property type="entry name" value="RRM1_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12371">
        <property type="entry name" value="RRM2_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12648">
        <property type="entry name" value="RRM3_UHM_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000136">
        <property type="entry name" value="poly(U)-binding-splicing factor PUF60 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034209">
        <property type="entry name" value="PUF60_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034211">
        <property type="entry name" value="PUF60_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034212">
        <property type="entry name" value="PUF60_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="152"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="249"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="517"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031575345.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="66406" checksum="56218B4472E553E0" modified="2020-12-02" version="1">MATEDMEISETPNLXAVNGEMSNSSKTDSTEEVPAASADGAEGGQRRRRKRGFDVGPDMGNGEKDEQPGDDGTXGELVLGPGAGGMQPRQSEVKRCLPALVYTQEELLKKAKRYAMEQSVQQVLAKQQAIQQQQMSALQTAAQRQRALALMCRVYVGSINFELREEHIRQAFIPFGPIKKIDLSWDPLTMKHKGFAFVEYDLPEAAQLALEQMNGVLLGGRNIKVGRPSNVPQAAPLIEQFEQEAKKYARIYIASVHPDLHEDDIKSVFEAFGKVVSCTLATEVMPNKHKGYGFIEYENQQSANDAIASMNLFDLGGQFLRVGRAITPPSSGGLSVPSFAPPPGTLPAAAALAAAAVSAKIQAQEQGIQGEIAFPTITIPTVTNVITPVITTPGLVTFPSAAGLLSTGLASQPLLATTAMISVPSTAVVKPVIATPVMTTAAALTSTTAAVVQLQQHQQQSVVAIAQQQAEVRAKIEEEAQRKMMEGSISHEENMSISGSNARYMVMQKLSRKIESKLMVLRNMVGVEDLDEDLEHEVTDECSKFGIVNRVVIYKEKQGEEEDAEVIVKIFVEFSSTSETEKAVAALDNRWFGGRTIKAEEYDEAKFAAGDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYQ4</accession>
    <name>A0A6P8GYQ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secretion-regulating guanine nucleotide exchange factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549354.1">
        <property type="nucleotide sequence ID" value="XM_031693494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GYQ4"/>
    <dbReference type="FunCoup" id="A0A6P8GYQ4">
        <property type="interactions" value="1217"/>
    </dbReference>
    <dbReference type="GeneID" id="116286900"/>
    <dbReference type="KEGG" id="aten:116286900"/>
    <dbReference type="InParanoid" id="A0A6P8GYQ4"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="215"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="330"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549354.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="40963" checksum="67E4AF78F15092C5" modified="2020-12-02" version="1">MADNRDNNITLLSWGSNSYGQLCNGHKHDVLYPEQSIPSPTRNVLALTGGGGHTALVSGDGKLYVCGWNNKGQLGLGDTVDRATLTHVLGIQAVRHVACGWNHTLVITDEGCLFVFGSNAFGQLGLGACEGNISSPCQVSLGSKVTDVAAGLRHSLVLLDDSSVWSWGDNKRGQLGIPRSKTKTVGTPTKVAILSDKACQVAAGSHHSVVLTENGQVFCWGSNQHGQCGKPVNTETKGHHHNFYDTPQLVCGDLRNNKVKSILSGWSHVLATTDDNQIYSWGRADYGQLGLGDEIVNVGYSWQPSRIPDLSGVKQLVCGAEHNIALLDSGEVLTWGWNEHSICGFKDEHNLHTPTTLSAVGESRKVRLVGCGGGHTFLVISQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ69</accession>
    <name>A0A6P8GZ69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-binding protein IPP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549514.1">
        <property type="nucleotide sequence ID" value="XM_031693654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZ69"/>
    <dbReference type="FunCoup" id="A0A6P8GZ69">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="GeneID" id="116287041"/>
    <dbReference type="KEGG" id="aten:116287041"/>
    <dbReference type="InParanoid" id="A0A6P8GZ69"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF35">
        <property type="entry name" value="ACTIN-BINDING PROTEIN IPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549514.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="64830" checksum="E92084EBB8B5C9E6" modified="2020-12-02" version="1">MTERKAARSRLAQEHSSKLLARLQHLRKQTRMCDGVLSVDGRQFHIHRVVVCASSQYFEVLLSGGMAESYSSTVEIHGVDGDVFSLIIDFIYTGYIDVNEGNVQQLLPAAKMLQLDDIERCCCEFLHRELDPSNCVGIFLFAETHSCTELRKSALDYVHRNFLLVSKQEEFLQLGQEPVLQLIDSEHLKVDTESHVFEAAMDWVLYDIPKRRECLGKILERIRLPLMSENYIKYYINSCKNASLKRMLENILQSYRSYQIIARNTLKNPLQPRKASRKCFYIVGGYSRSVGARWSDRSSLSICEKFDSFSHKCEVCSIAPLEIPRCNLGVTALNGLVYAVGGEDDSLLLFDSTECFDPALNTWSTVASMNAPRVGFGVCIVDNCIYVIGGLIGGWGGTEVAGNIEKYDPEENQWSIAGSMGTKRFHLGVEELNGLIYAIGGISEHAEELRVAESYDPVRDKWTRLPDIKTARAHMGVASLGNAIYVIGGSTENGHSVLDSVERYDPEHNEWTEVAPLPSPRAGLSAAVDMKVVYAVGGISAKKEYSAPSTLTAIDAYDPATNKWSRVTNLNTSRCEFGIGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZM1</accession>
    <name>A0A6P8GZM1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein LOC116286221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116286221</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031548541.1">
        <property type="nucleotide sequence ID" value="XM_031692681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZM1"/>
    <dbReference type="GeneID" id="116286221"/>
    <dbReference type="KEGG" id="aten:116286221"/>
    <dbReference type="InParanoid" id="A0A6P8GZM1"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000081">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
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        <property type="entry name" value="K_chnl_volt-dep_Kv5/Kv9"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
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    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
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    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01494">
        <property type="entry name" value="KV9CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
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    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="969"/>
            <end position="986"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="1006"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="1064"/>
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            <begin position="1105"/>
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            <begin position="1163"/>
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            <begin position="817"/>
            <end position="886"/>
        </location>
    </feature>
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            <begin position="444"/>
            <end position="477"/>
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            <end position="810"/>
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        <location>
            <begin position="916"/>
            <end position="943"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="447"/>
            <end position="464"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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            <begin position="557"/>
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            <begin position="664"/>
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            <dbReference type="ARBA" id="ARBA00022958"/>
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            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
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            <dbReference type="PROSITE" id="PS50097"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031548541.1"/>
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    </evidence>
    <sequence length="1190" mass="133752" checksum="0AE401D648052A05" modified="2020-12-02" version="1">MNDPLSSNHDGLRECRRKKRFIVVRPNPQRSLGCSDSTIYSLTSMSKTQKLAWEGKCRLKKNISKSEPYLKDLESSIMASNDIELRNSGSLRSKDGRIFEGARFLFSKLSTRIADDSILVPQESVSCEITDNADDFNAKIPTPVTLDCKGRIDKQDENLTEQYNGSKKETEVVKEKISSFKGLLERQQAFEEESSNGHVDVGSDVSHLLNPIIGIINGNPTNETTSENETNLYALSFIDNESRELRKPAAKITISCPSESVAGGNELQATKSENETMKNEKEKVYQSVMSVDGTSKLDGNTRWKATSFSYPCVHRGKEYNTKRKTVQGNNDETKCLISPKRTENIVKLEDEETSLSERENGNFSKLKNNGVELSAGSFEKQKNDDLLMDMLRGSLNSNYYRSPNIMDVTNKDSNNLLKTGNRLHSLSEPKLDTKCRENVSVTVSPQHDVKPVDITTDNKHDEHPGTSTSGDLSTKKRNRVKLALATSHAGIYVTGESQDDTTSSDSPMGWSFERCPSWIGKESNDSPFLSPYYQPSSNEEKDESPVISIQKRKVSPISLSCTKQKSNSSEKDSGASWSPHSKTSGFSVQDSGFEASGRHSTALLSPSFRKMTLPITSHPGISTSGEMYSSDEYFTYSCEGNMLSPTRSQESKRESRRRKVAIGSSRTGSNDFTLLSPTFKAQSYEEPDRKSRKISYPYRFSNSTEGDSGLETPHSAASRSPHLERNPISTQSSVSSRGHHERSSRFSIQSRLSSKSSMKSGGSSMRFSNPIESLKGSFLSFLSPKNFFGSRKSSEAGKSSSCGSKSSRKQLADFPDDEKILLVNVSGRKFKLHEYFTTVYPKTLLGNVSRNKYYDANKEEFFFDRDPDIFRHIWNFYYTGKLHFPKDECVSHFVDEISFFGVADEYLCTCCWEDEFEPAVEKLEKLRKEIEKKEEEKLAKTRKIPENASLREKIWLTTKDPVVSTQAKMFYFLSMLAIVVSTVASITETIPCSMTLKVCKENNQDVYFYIDSGCVAFFTIEYLLRLITAPKRLHFVRKFMSIVDLLAIVPYYCDILMRQIFGPSIAYGIGLLEILRILRIVRVFKLLKHSRRLQSLVNTFKSSTAELSLIVFIYLVLVTVFASVIYYAEMQDNPKYSSIPESMWYAVITTTTTGYGDIVPETIIGKLIGCACCLLGVLIVALPVPILQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H039</accession>
    <name>A0A6P8H039_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC116286378</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116286378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DZIP C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548746.1">
        <property type="nucleotide sequence ID" value="XM_031692886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H039"/>
    <dbReference type="GeneID" id="116286378"/>
    <dbReference type="KEGG" id="aten:116286378"/>
    <dbReference type="InParanoid" id="A0A6P8H039"/>
    <dbReference type="OrthoDB" id="515971at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058883">
        <property type="entry name" value="DZIP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032714">
        <property type="entry name" value="DZIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF3">
        <property type="entry name" value="CILIUM ASSEMBLY PROTEIN DZIP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13815">
        <property type="entry name" value="Dzip-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25977">
        <property type="entry name" value="DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="755"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="333"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="906"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031548746.1"/>
        </source>
    </evidence>
    <sequence length="1027" mass="116319" checksum="003474103D23CF11" modified="2020-12-02" version="1">MNFTFGKRTEQVDWRKLAAVDLDRLTREMDVKTLQDNILNVTYCNIEAELGMQAVNFDPNFIKLFNLAQLIIEYLLHSQEYLSSNLETEVKKVQETMQSAEEVRKELEQKAEAQNKLKKEIKKLKKWIAEYQMMMRAGASGIHKCPYCAKAFVSQEYLSAHLARRHNDDGAHMNGYITSVKPVNITVSSKLANGEVDQDKLALVEEMKQIKDRLYATERDLMNERAAREMGSAREKDQSSSDQSKFREMEENYENWKRMEEERHRREMDNLKNTLLQQMQELQMQSQAEKESFNQAISDLENKMTTRPSMIGSIKDEDEPDGPSKGEIADMMKEQLELIKAQTQDDMQQEMKRLNKKWKTKEDKLQTDHENEMNKVRELLNQYEDKLTTEQSEKDELYKKVRELTKKLNEHDKAIEDSKVAAEQYQQAARQQPILATPPVPRREVTFSDQDLLERDRAKTPDFDNNKDDAMMLFVAANTNRSQYRLWRQRAEGSSEWVDKFNFNAYVRPVGPFTTPVYVYAASGSPYWRQCISGNSKPPSNEYRLDYMFYASQSPVLGSVQLHVLDAGTLPVVRSCVFKSKDLPGWKYKGFSFYAMKSNPKGVNVSSSFEGDQESEESESESESEINKVTEVMKASLESTDTKDMTSGMSSSEWGTGTLQRGEFHPFPHNPDITTHYRHTHDEVMACRQEIEQMVEQKLAKQSLQTSIGRLSSERMNAHMAALATERQARAKKMRNFDQLRNSLSKDAEEIAKRNYKSNGAKAGTPQQLIPRQGGVSPTTRSKPPTMKATATAVRASSSLQQSRNSTKSSMTLSSSGSQDMGLSTGTSVTDRTLSESDPEEEDDSEYSQDGSEWDSTGKSLTPVPAPVSRGQPRPLPTNPKVSVRIPTHDIESDPEDIQPAPISTHYPSSSPGNNNVRGLTSSLERSLGNNNTGKKPVGGVALPGKHDFDDSDFSLSSIEEKTKPTQLTRAELNRTGNRNESTPVPAPRSRPNPSPRKDAPSSSAVEAFSVDDISDFDDSELEMHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H230</accession>
    <name>A0A6P8H230_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116287202</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031549703.1">
        <property type="nucleotide sequence ID" value="XM_031693843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287202"/>
    <dbReference type="KEGG" id="aten:116287202"/>
    <dbReference type="InParanoid" id="A0A6P8H230"/>
    <dbReference type="OrthoDB" id="5975740at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000088">
        <property type="entry name" value="Receptor protein-tyrosine phosphatase LAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027553065" description="protein-tyrosine-phosphatase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="6811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6166"/>
            <end position="6187"/>
        </location>
    </feature>
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            <begin position="24"/>
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            <end position="473"/>
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            <end position="769"/>
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            <begin position="775"/>
            <end position="845"/>
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            <begin position="890"/>
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            <begin position="5699"/>
            <end position="5794"/>
        </location>
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        <location>
            <begin position="5798"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="5894"/>
            <end position="6000"/>
        </location>
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    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="6249"/>
            <end position="6507"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="6425"/>
            <end position="6498"/>
        </location>
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    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="6539"/>
            <end position="6798"/>
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    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="6714"/>
            <end position="6789"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031549703.1"/>
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    <sequence length="6811" mass="756271" checksum="360A3869DE067C65" modified="2020-12-02" version="1">[encoded data, 6811 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H366</accession>
    <name>A0A6P8H366_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116287358 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116287358 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116287358</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031549890.1">
        <property type="nucleotide sequence ID" value="XM_031694030.1"/>
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    <dbReference type="KEGG" id="aten:116287358"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
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        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
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    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="443"/>
        </location>
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            <position position="328"/>
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    <sequence length="942" mass="105657" checksum="D2EBB56A289D1817" modified="2020-12-02" version="1">MHRQGSGKRKIRMYQHXRPNFDRAEDTSKPWAKTGAWFLGPKADNAEEFKGFVNRAIETHIKFRDSYFPFDPPYVTDEMRQSASFQEVMKKTDDELQNMQKQLIKAVPFFSSRYKGHVTWDTVMPSNLGYITALLFNANNCAAEASTVTTPYEVEVGLDLCKMVGFDPDKAMGHLVTGGTLANIESMWAARNVKYYALGLQEAILKEDALANARELTVYLPSKKQDVKIVDATSWELLNLKTDEIIELPERVATRCAISESDLSGILSNYAYESIGTQVFLERHNLKTNPCSLAPTTAHISLFKGATITGIGKANLITVPVDENARMDVKGLRDILEDKLANQIPVVSVVAVMGTTEESAVDPLVDILEIREEMRTRGLDFMIHADGAWGGYFCTMLRTPPTPLVQTSEDSSWFVPELNXNSYTVAQLSAIPNVDTITIDPHKSGFCPYPGGATCYRDRRINNFLGITNQVTYYHGSLNLGDVGIEGSKPGAAAAGVVMAHRVVGLHKNGYGRILGECTFTAKLLYCYWTTLANWDDPFFIVPTKPLPPGRTREEHIKFIKRHIIGKTNEELVENDEVMEYLREVGPDTNVPCFTLNVKGNTDVNKVNDIVQAVFKDLCMSDDRIASFRFPMIVTASTYAHHPHSVALKELKKRLGVDPYDTTGVKYIITTCMDPWATSMEFLEELTSIMRNTILCSIGTVTDPNVHHDLVTTGHIDGKNNMIVYYAGKFPNVSHQYHALAKVQFINPADGEPAIQGAARRGTEPLVLRSVEQKCLHDLLLYDFEEGEEGRREPEVEVDCYSGIPTGDNRPFMRTKIRVVDVSRFDHFDASVFKYPDKSTYFLYGDEEKAYISHIPVKKPDFLQLVELEDIPYGVSKILLSYGIEIEIVGIPXERRSGGEIDDPLTESSYIVSFIGEDAEEQRATIKIGRKIWFDSDFINND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4G4</accession>
    <name>A0A6P8H4G4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116288576</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551239.1">
        <property type="nucleotide sequence ID" value="XM_031695379.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288576"/>
    <dbReference type="KEGG" id="aten:116288576"/>
    <dbReference type="InParanoid" id="A0A6P8H4G4"/>
    <dbReference type="OrthoDB" id="5966293at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028279547" evidence="8">
        <location>
            <begin position="22"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="228"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="485"/>
            <end position="665"/>
        </location>
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        <location>
            <begin position="740"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="1303"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="1500"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="1706"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551239.1"/>
        </source>
    </evidence>
    <sequence length="1894" mass="209056" checksum="A217F6E04929AC3E" modified="2020-12-02" version="1">MELYTLKLLLPLLLQLLTVNAQEQDRCRKNVDLGFLMDSSGSIGDQDYQKEKEFVKSLASTFILSRRNTQAGVIIYSDDALMYSTFGQYPDIERFKRAVDSLPYLRKRTRIDKALKLAATNLFTSQGGARPDKEDIMVILTDGVQTPDPDAVPLVDAVLPLHEAGVRVFAVGVGGHYKRSELLQLVERESDVYEAADFDELLRLVKRIARGTCAPAPVIVPKCRYRADLGFLMDASNSIGETDFQKERDFVHSLASAFTFGHNETAAAVITYSDTATLNIPLGHHYSVDSFKQAVERIPYILGRTRIDKALKLASTDIFSNRGGTRPGLPKLLVILTDGVQTPDPDAIPLKEAVIPLQNKGVTILAVGVGSRIDYNELRSMVQKDNDVFTATDFDDLLNKAYQISEQTCEDVKTQIENVDGGWSSWQPWDTCIPSCGGGLQTRRRVCESPFPRGNGLPCQGPASETRACNQQPCQEVKKCTARADIGFVMDASASIGEFDFQKERDFVKAVADSFTLASDQAIVGVITYSDNAKLDIPLGKYMSAERFKLEVDRIPYILGRTRIDKALKLASTDFFGKNGRSRPGFPKIMIILTDGVQTPDPDAISLDQAVIPLRRAGVRVFAVGVGGHTRPSELRLMVERPDDVFMAEDFDDLLQKTYVIAQRTCEGAQDKPVDGGWSSWQNWDKCIPECDGGQQTRRRSCNNPSPAHGGRACPGSSSETRACNQQPCIGKIQCSARVDLAFLMDASGSIGKWDFQKERDFVKAMAASFNFARDQTLAAVITYSDKANLEIPFGRHLNTDSFRLEVDQIRYTLGQTRIDKALAAAADKVFAPGKGTRPGFPKVIVILTDGVQTKDPDAIPLGQAVLPLRRKGVQIIAVGVGGHADPNELRQMVERSSDVYTVSDFDDLLKKAYDIAQRTCDGASRPRVNGDWSEWSGWTTCSVSCGSGVQNRKRNCDNPYPSNGGYPCSGQSEEERSCYERACTGNLRVNGGWSDWSRWSRCSVTCGTGVETRQRRCDNPYPSNGGYRCSGPSEERRACYQRACIGNLRVDGGWSDWSRWSRCSVTCGTGVESRQRRCDNPYPSNGGYRCSGPSEERRACYQRACIGNLRVDGGWSDWSRWSRCSVTCGTGVVTRQRRCDNPYPSNGGYRCSGPSEERRACYQRACITSRRVDGGWSQWNDWRQCSRTCGGGSQIRYRDCSNPPPSNGGRDCYGRAQESRLCAANPCPARIDGQWSPWSDWAQCSRTCGGGVQSRLRTCSNPSPSNGGRDCYGIRQESRLCSTTPCAVPIPTTSDCQNLNAMVGILMVDSRSVGQENFKKQKDFVKRVASSYGLSTTGTRAGIIGYSDSAQVYAKMGEHTDQASFERAVDRVIYTRGTSRFDKALKLASLRFFPSSGVVTFGIPRILIVLINKPLTREFDTVPLYQTVLPLRIANVKVFVIGIGQQVNRNELNVVADDEKDVFLVRDFDDLLARSRQIIQSSCSEYLPKTRARCLGTSDLGFILDASGSVGAVGFNKQRQFVTSVSSSFNVGPSSTHIGVITYSSFAVVRLRFGEFNLMDQITRAVATIPYTRGQSRIEEALKQATNDLYTVSGGSRWGLPKIAILITDGLQVQNPDVELRQASEALRRAGVKIIAVGIGNDQDSDNLRLLVNSNNHVVIVRDYDELLRRANEIALLTCNGVRGSFPTFNPGNIGSQISCPNVMDLGFAMDSSSALGIKNYLKEKYFVKQIATHVGLRPDGSRVGVLIYGDTSMVEIRMLHHRDVLSFTNLVDRLPYYSQRRRIDKALETANLMFQVPPQSPRVLKVFVLLVNGKQTLTYNSVPLSQAAQPLRNAGVRVIVIGVGNVSANELRSVATNSRDVYLIPSFDVLISQVENFKRIICEAGARSSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5M3</accession>
    <name>A0A6P8H5M3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transferase CAF17 homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116288943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551669.1">
        <property type="nucleotide sequence ID" value="XM_031695809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5M3"/>
    <dbReference type="FunCoup" id="A0A6P8H5M3">
        <property type="interactions" value="872"/>
    </dbReference>
    <dbReference type="GeneID" id="116288943"/>
    <dbReference type="KEGG" id="aten:116288943"/>
    <dbReference type="InParanoid" id="A0A6P8H5M3"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="4">
        <location>
            <begin position="261"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551669.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38289" checksum="7BF677D0D7936195" modified="2020-12-02" version="1">MAARGVKFNIANLPRFTRVNHQLFFRRTAHNLSGDSLKYCQLEKRSLIRVHGADSVRLLQGLVTNSVELFHQDGSLKTMYSMFLNAQGRVLYDAMLYKDKTNSGNPCFLVECDKNTLPGLLKLMTFYKLRSKVDISRVADIVPWVIFNEKSSDTTNLDVKMDSNLISFGRDPRIKELGWRLLLTGGCKPSDLLDGIHGVNESSYDIYRVKLGVCEGASEIQPGTALPLEYNLDYINGVSFQKGCYIGQELTARTHHTGVIRKRVMPFKFAPVEEVIKLEQDMAIKTSSGKTSGKLCVVYKGCGLAVMRIAMLNNNKHYVKDNEGNDVEIHPYVPKWWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5Q7</accession>
    <name>A0A6P8H5Q7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550763.1">
        <property type="nucleotide sequence ID" value="XM_031694903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5Q7"/>
    <dbReference type="GeneID" id="116288154"/>
    <dbReference type="KEGG" id="aten:116288154"/>
    <dbReference type="InParanoid" id="A0A6P8H5Q7"/>
    <dbReference type="OrthoDB" id="5981973at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027635307" evidence="1">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550763.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22814" checksum="A5CDA1C643BB2C64" modified="2020-12-02" version="1">MNHSWCEIMLVVWYSVVLLLLHQPGDITASLRWPGGIYGLPKPKSGCPEEWGKNRWEENGAMYQKTTQGRTSNDKSNDLHLAGYVKPREVKINFCISKTNPAGRQPWPKGEYCIYSRHRIRSMVWGFIRMYDVGSKTSASNTCSNTFFEVKWYHYNRKSYLYSVHFKCQTRGNKKIPISLPITKPFYLLPYGSRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8V9</accession>
    <name>A0A6P8H8V9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZP domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116286477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548860.1">
        <property type="nucleotide sequence ID" value="XM_031693000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8V9"/>
    <dbReference type="FunCoup" id="A0A6P8H8V9">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="116286477"/>
    <dbReference type="KEGG" id="aten:116286477"/>
    <dbReference type="InParanoid" id="A0A6P8H8V9"/>
    <dbReference type="OrthoDB" id="5965424at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028189631" evidence="5">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="6">
        <location>
            <begin position="52"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031548860.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43139" checksum="36589CE8A3C3C352" modified="2020-12-02" version="1">MEKTLVVLLSMALIGATVAQETATPAPTTAAPAATEAPTTTKVLESYGLTVTCTSQYMEARLDITKHTGIRTDTVALEDRNCGVTRSERDFLYFRTALDGCKTKHNTTSDSIVYYNSIYADTGSGSNSDKISRAMQAEFPFKCTFPRAAILSVVSFSPRRKVVYTRASDFGNFTFYMDLYQTNKFEKKYEDYPVQVNLNELLNIKVGVQSNDSKLAIFADDCWATPTEKADDKDNTHTIIDGGCKKDDTLLYKFKPNNSSQNFQVRAFRFVTGRTNDVYLHCRVEVCREGDDNSNCVKGCRAGSRRRRSLVSDASSETLTIGVIKLTQNANAQSATGNASSFTTISIIAGVLGFLVIALVAVLVVVYKRRQATPVNVVFKKVSGNEADQLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H975</accession>
    <name>A0A6P8H975_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116289332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116289332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031552081.1">
        <property type="nucleotide sequence ID" value="XM_031696221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289332"/>
    <dbReference type="KEGG" id="aten:116289332"/>
    <dbReference type="InParanoid" id="A0A6P8H975"/>
    <dbReference type="OrthoDB" id="5987246at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="509"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="825"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1372"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1289"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031552081.1"/>
        </source>
    </evidence>
    <sequence length="1412" mass="160670" checksum="3D1ADBD2416EDB8B" modified="2020-12-02" version="1">MFANTSPDDIANDDYVYEDIYSIQPQGNALCGVNEVYVTMGTVPEQEYADNLYENDPSIYQNITQKSRKRKAVFGEGIYSATGHPAEGNWNPSYQKGISVYPPDTKTTLEEFIKNHEEYLSHIDNTPADEDNSERVQFLLHKVFPYLERKLAKTGITLDILNILVTLSCCRKCSLVTRHALYMILDILSTTSYDSSGIFNDFIIKCESNLRDSILGQAQEETAVFDHEIADDQGLRILAYSRVLMIFYVNIVQGLIPPVELGRKDMYEDVVQKLIQVQEQNVFNEKEWPRYAIRCIKEIQARVKQTPQKKKNDAWKNFLIWLQEHNRTGEVNKGKRNKSVGDFLSKIKASKKAWFDFHVVVFSLGSQIKERPGNIEILRTLVEMYLKSHSDFARKWSSEGEWQTGLVLGSVLEGIVNHNQDKDTRTEACLCLVHYFANLTKRNSGEKLWAHESLHRCLYGQVGNCRQIMLNNLEIKGGDGKPTKGEKELLPITRSMDHLLQIYKRQLSKRPLHFIGKSNKKGYYSATFRGENAMIKILESSTDDILGEEKMAPTRIHHQLVIEAYTLRRLNSKPHPNILRVFAYDTSAQPYHLITEQVAKGSLLKFLQNSRSHLGHMPSPSELVKMILGVMDAVIYLNDHHLVHLAIMADNVLVAQDNVCKLTGFQFTREMTKQGNGIYEYVSVLDEMATRHAAPECFKLGQFSEKSVSWAIGVMLFEMHTYGVSPYNQYRNHEADQIRNHVISGGKLKMEDCIRKEVCDLIEKKCIQHEREKRIDLMQLKMELEMIYEQFKREDNDCPPASYPSLTIVDLAQTKDTMXSSSALEDRDKEKNIGFFGSPTRSHDIPIIRLANGVRVIRELVEKTKQADLEILKNLKHRNIVVIHSLSNHDERYTALVTEDSGRGNLLKIILDKQCRRETLVTFIAQIAQAMEYMHDNDVIHSDLRAEHIMIFTNKVKLARLGRSKSVGKMVDTKCKMPEDAVRWSPPEVIKDGIYSHSSDVYSFAIMCFELFSALSAAEGSKAEDVKPFATIKDDQVLAYLEGNNRPCRPERMPTWVYIAVKQCLLHKAAERPPFVLIVDALTSRKPFDSCLLSFWIXKHPNEAEHINTNKTQPQGASHVIPMEEHKTFEELCKSVPVEVFMKHTYAYKPGNKDSVEDQDNEPALQDQEELYYEIDDSNKAFKSKVPEHSFYEQIPNLGIPCQRRPLPLPLPTQETGNPTLVRENSEFALYASTSIINLKSSSSLSLHDHETSDSFYNNINDGSTLSPDNREWPSLPGPPKGDGKNNNKDSSPASSSSNGESTHFTQTSSYPMPASRANANLRVQRQEDGGAVGGEPVQGSLYTREEFGNNEQENMSMNPGATECSWYSMTPLYEQEQNNGSGSRDLIEDNNRPAWRRPVPLPRSKGPKHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9K5</accession>
    <name>A0A6P8H9K5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptonemal complex protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552206.1">
        <property type="nucleotide sequence ID" value="XM_031696346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9K5"/>
    <dbReference type="FunCoup" id="A0A6P8H9K5">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="GeneID" id="116289428"/>
    <dbReference type="KEGG" id="aten:116289428"/>
    <dbReference type="InParanoid" id="A0A6P8H9K5"/>
    <dbReference type="OrthoDB" id="10064612at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008827">
        <property type="entry name" value="SYCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46918">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46918:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05483">
        <property type="entry name" value="SCP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552206.1"/>
        </source>
    </evidence>
    <sequence length="976" mass="114236" checksum="A7AF76B9B2583CDA" modified="2020-12-02" version="1">MEKEMPQDPERMQSLHSKLHQEAEKIRQWKTSTEIELKQKERRLVEASQKLETQRNAILELQLHNERISSKLQDEMACRQEVEQKVTSTRIMCNALKDHFAHLNKKIKEGENDRDELKLIDKHRMDQYQEMLIKFQELEIDQKKKLDSMKAKVEEEKDRYEDCISNLQHQISYLTTEGEEIQKKIDIMKTSVTEKDKECERLKKERDNLKDRINKMDSAIISLQVTLENTDEMLLRSKEETKNMEEDLNFSKSKLEECEEIASQQREEIAKIEENYQEDIRKLKEQITNLQENAENKQKRLEECIVKYTKSMNEIQLLEKKLDSVLKDNDAIMEELEILRKEKTVFEDLKRKFQESKNDISTLQKEKAVWSEKIMEKEESIRNLKQEIVNMKDNQKEQAKIKEEIQCVLDQEKSVNSKLQHELQQTKEKEKERMKMHEDYTRLKEKSVALEEKYEKLNEYVEEQHHKTTALMQQEDANVKKLRNEAQEKEKRTKSLEKKYENLQAQLGTKTKTIKELQQEVKSLKSKMTSQTKQSDKLEHQASSLSDQVKNKNEEIKDLTTQVALVLLKKSNDQQEATNKSLLSFEQKIESLKKELKEKEKKTIYLEEEAVKLKELSDQSVKDKDDAKKTFEQQMAELCSTLEKYKMENERIVAQKDRELNLMRQKLKGDKEESTQVQEKKMKEMKEKIASLQKHLETAAEKQKELASALEKEQGTVLSLQNRLSDEKENMKSPRTPRKGTEHQVPETPEVSKKLAGTTEGFWTPQTSAMTTPKGIRTPTIVRSILKDQSGGSKKRRVVFAESDVAVSISSSDDEECLPKTNKEVTDDKEVNVDDRKVPSHVSKPNVRHSPKPASWKEDENKTVSKTQQLVVNETKPLKPVPRGKPVRKPKKMKMSKEDTDELTKFKDLFPDIKNTETLLAKTPAGRKTSTEKKKNAPFKSKIKEIKPIIKKKTTGDDILDWFDTDALFGFGECDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA87</accession>
    <name>A0A6P8HA87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116286955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116286955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549415.1">
        <property type="nucleotide sequence ID" value="XM_031693555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HA87"/>
    <dbReference type="GeneID" id="116286955"/>
    <dbReference type="KEGG" id="aten:116286955"/>
    <dbReference type="InParanoid" id="A0A6P8HA87"/>
    <dbReference type="OrthoDB" id="6495021at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031549415.1"/>
        </source>
    </evidence>
    <sequence length="850" mass="93980" checksum="B51912157AD9F87B" modified="2020-12-02" version="1">MGSLCTALTTALEVYRGKCVMADGFEVKTIACFSRVRLFSRCLIRSILTKKEKEILFVTKGDRFLYVIENGRHSNTYLFPSDVIYFEVFGQSITAVTDDGRVWRTAITKQKIKKNKHGSNQESGSASSQAIFTELLSKERKNCNQVFNTESSVDITEILASQAILLEPKILAIFTLEDCLISFGVNDFGCFISHYASSKQENNTVSYNQTAFKVSLNSPAHLHKDKLWPIPLLCYSKKTDNDLPSNILERKLFNLLVPRGGFDELKTTAINCLLLLGTPDGQVLTCDLDQTGSETIGKSSFKLLYHLEQSVVGLHLIQLPQLHTSSRSTKNEFMSVNEKNPVYNVVVMIGSKGKCVLAYQVDETCSFSKHNLAGPIYCSNVKSSKDSTRIIHSNGREVCISTLSVNKHKTSEKDDVSIVLSSIFICIPDICCVYCLHPNVQDANSTSTSIKAVAMTTKGKLLGISLPGHDSTFSFTQQPGLQLRELLVRIENVALQTNVLEQDLESIDKVLEQLNYAATLMTKATSPTGNSTMGNNLSNQWICWNVVPILASEDSILTNRLSFSLKLGLINQSSISLSSQWSVLISVQNKNSVLSYAVALESLTPQSTREFVITLPDSVDPRHCIVVETFLCYDLSSLPSTLPSEVQPCLNVDNNSLVISLGENVIDILSLARILFDFLSHDVCKFTVANQGLYLEHLQSSCKDDKSISLKQHTVDDELCAIVIPVSKTFLHSISSIGSKDNMEEKVLHLLLGDLNDKSFSKKDVRTSTRTSKANCCSMTVMVTASTSDEEPHDGVNIVLKASAKIGLLMLLEAVIARLKFLSKTNEVTVRADDLQRILKAVQELNSKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAI6</accession>
    <name>A0A6P8HAI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Condensin-2 complex subunit G2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116287184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549687.1">
        <property type="nucleotide sequence ID" value="XM_031693827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAI6"/>
    <dbReference type="FunCoup" id="A0A6P8HAI6">
        <property type="interactions" value="1798"/>
    </dbReference>
    <dbReference type="GeneID" id="116287184"/>
    <dbReference type="KEGG" id="aten:116287184"/>
    <dbReference type="InParanoid" id="A0A6P8HAI6"/>
    <dbReference type="OrthoDB" id="10062843at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031549687.1"/>
        </source>
    </evidence>
    <sequence length="1166" mass="129954" checksum="803B8767B9A7DC97" modified="2020-12-02" version="1">MNLREAFLSAIEDENPKSFLDYIEQHNTKNETFDVTEVLQTFSKKLHERLWVGLKTLCNNQILNATPSADTDEYDVTQNEKTSIMLSCLQGITTVALCSISMDKPFIPPALFETAVILHGVMMCLPDDNQKLQGSIAQLCETWFLNDLEGKEELITHTLPFLVIRSLAKGTVADVKHVWGVRQGLLLMDFDDENSESLKQLLQQCMIHPTFLRAEEGHRFLSFLFGIHPGFIKELHKTIKNQIPVCSMDVLSTYGEIYFRAWRVASGPFLEVIENDCFQNLMYAAVHAQRTGTQSMASRLRKVLGYLHQQKKQQGVDEALVRLYQPIIWRAFKVANPMVRANAAALLIDAFPLQDPDANNEEVDNLLQKQFDILQNLLEDPSPVVRATGVHGVCRIAGVFWELIPVTTLKTLLNKLICEVAFDASSSSVRVAVFQGLKFLLENHLSHLFLKTLLVSLRDLIHDNSEKVRAAFVDLLLLVKGMKAIKFWSIVPLEHLLARLELETSAPVMRKLVKLLMNSFHPLNKETDIQITRCTALWEANPVAARRFYQYAHLHTSVHATGKFILLLGQCLSHWAKNVGSADNTSVEDITRTDSTDNKENEGIDESADAVLTLPDVNTIAGILETIAISWAGIKDQLEKKANESIKGKLTQQFTKALPKLISSTEDGRARAALVLISSHLPSNCLPAFSKKCLSTLSSLHDCVSTQDYGPMLDCLCSWGQAGDVLEIIYTCLLNKMKGDIGVTMANRGKSHTSSKLPKLEVTTALDLLSWLLYQPACREAVMNHDKRLADIAGILKDVTNLIEGDLLGATNPKSKRSNNHDTTLELYPKTLKMYCHLQIHLHSKNCSSESVKAAETVTELLVWAERVLLPSLPSYSDTSEGLTMEKGKRTRKEDDSKDLSCAKDTLEVIISCSSELLKLGMADNTFCCQVTLLTKTLAQLGEKGLPFLPSLVELMYQMSQRMIFLDEEERPTDYTQGMLTDILQAIAKNSSSENISQVLMGVKTPLAEVLKTYECKRQAVIAGFADRPQIMACTMAACLAELSHKTLDMQEEPTAADLPTLSFFVLSVLIKSKILLRSFTEELEQCIVSGAIQDAELLASATFLLAVIVNANSKLDNLKSCGLQILQQIDQLPVDNEQSQNEHQINPEQIKGMAKQILNRLGVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAP0</accession>
    <name>A0A6P8HAP0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-glucuronosyltransferase 2B7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116290602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553529.1">
        <property type="nucleotide sequence ID" value="XM_031697669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAP0"/>
    <dbReference type="FunCoup" id="A0A6P8HAP0">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="GeneID" id="116290602"/>
    <dbReference type="KEGG" id="aten:116290602"/>
    <dbReference type="InParanoid" id="A0A6P8HAP0"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031553529.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54716" checksum="76919CC2D9A59C28" modified="2020-12-02" version="1">MMPHFGRSHYMVMAKLGDELKARGHDVSIFVGEEDAFAFGKPNVKVFETPIIEGKPSVLDHFKSMSSTEQKAFMSQASQVFQHQRDYCDLFLSSEHAQRELQDADIVIGDGLYPCSSLVADKYKIPHVVVTMSPLCTPTFRVFGISSNPVYIPQMMSELTAVKGLANKIKNVGFYFLAVFAMEYFMYPTYGKLKLKHEVTPGKSIRDTLANADLVLMQRDFIMDFAQPIPPYVRDVGNFLYGPAQPLPAELEKFMEESGDDGVILVSFGSIVNTLSDDISVVMNRAFSQVKQRVIWKVDKFKGKLSPNVITQKWLPQNDILGHKKTRLFITHGGANGLAEASYHGVPMICSPFFGDQQDNGRFIKSDGLGEVLSVAKATTDQLVSLINQVIYEERYKKRASHVSRVLKLRPRSPVKEAADLIEYVQAVGNLDHLKPKSMTLPFYELYMLDVLFVLGIVFAVVSYILVAMCRLVCGKIFSRGPKKTKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAT2</accession>
    <name>A0A6P8HAT2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase MYLIP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116289920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552726.1">
        <property type="nucleotide sequence ID" value="XM_031696866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAT2"/>
    <dbReference type="GeneID" id="116289920"/>
    <dbReference type="KEGG" id="aten:116289920"/>
    <dbReference type="InParanoid" id="A0A6P8HAT2"/>
    <dbReference type="OrthoDB" id="10037309at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17104">
        <property type="entry name" value="FERM_F1_MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FERM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031552726.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55019" checksum="D50BD1C21D5CA861" modified="2020-12-02" version="1">MWCFVSEPNGIIHEIFLPRNSVGQECFDKVCEKLRLVEKDYFGLQYNGPNGVRLWLNMRNAMSVQLSGKPPYRLYLLVKFFVKPQELQQEISRNLFYLTLKTFVSHGKIDLSNSQTKTIARLCALTAQIDSGDFIPEKPPQYSTFIPKALYNFYSKTSDLQKDAASEHTQLLRTPVNEAKVEYLHLLANVPGYGIDVFKGKMSKEKCTKKVEICVGNDGVKVYSVSQEYDAKQSREIVKKIVEKRINFEDVSTVSYNNRCFTVVHGSGTQAQRVTYKLKSECDAVALFRTFTEFHTFYQCNTVKRSVVDQCTRTLLGRLVSVVFPSNDFGKTYLFDVQRTRRQAYSHAWNEMNSYRNTNMSRVTAGNSRSGYSVSEFRPVQSPLSRRKCSGSRQKDLAEFEEQNLTDLDIEAMQPEELKKMVRHMQDARICQICMDAEVATAFCPCGHVVCCVECSAMCKECPLCRSQITYAQRVFFPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC96</accession>
    <name>A0A6P8HC96_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291075</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554054.1">
        <property type="nucleotide sequence ID" value="XM_031698194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC96"/>
    <dbReference type="GeneID" id="116291075"/>
    <dbReference type="KEGG" id="aten:116291075"/>
    <dbReference type="InParanoid" id="A0A6P8HC96"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554054.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12798" checksum="F1D6BEA19DE29B6C" modified="2020-12-02" version="1">MADEISLPDHYVNLLERVIEENKSLREEARANAVLQQKVLEELNQNKASSSDSGKRPRSSKRASTKLIVPLLCRQDFRKTYKTLLKGESFKGFNMDESFLSFGSSENQEITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCJ9</accession>
    <name>A0A6P8HCJ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116287853</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031550407.1">
        <property type="nucleotide sequence ID" value="XM_031694547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCJ9"/>
    <dbReference type="GeneID" id="116287853"/>
    <dbReference type="KEGG" id="aten:116287853"/>
    <dbReference type="InParanoid" id="A0A6P8HCJ9"/>
    <dbReference type="OrthoDB" id="5996418at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028460311" evidence="3">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550407.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28106" checksum="8DED259F576EA108" modified="2020-12-02" version="1">MSFELVWILQFILTISGEILQPKELKRNEGEEVDFKFTTKDRNSIRTANFGKKTSLECDHTMKLIIVTTQIVTHGKDLDTASDRQYKNRAHFIGNISLGHAWFRLINVSVADQGVYAACIRQDTDLKRKMYEVKLSVKPSSKRGPSARSTIGSRKSTTSSSNPESPVGLITLPSLSILFSLCLILVLAVPKLLRVLNDPFLCQRLKTRITAVFEMILGIIRRVYGFFIQIYRRRRGRTEQSRTEPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDJ1</accession>
    <name>A0A6P8HDJ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116291451</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116291451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031554479.1">
        <property type="nucleotide sequence ID" value="XM_031698619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDJ1"/>
    <dbReference type="GeneID" id="116291451"/>
    <dbReference type="KEGG" id="aten:116291451"/>
    <dbReference type="InParanoid" id="A0A6P8HDJ1"/>
    <dbReference type="OrthoDB" id="5974958at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554479.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14030" checksum="B8EBB4A2404F3347" modified="2020-12-02" version="1">MSVALTGTGVATSLTGPGIVVGVPLASVGAVCGIVSAVTTGIIKQLSGKISKHDTHIALARAKANTIADLVSKALRDRRIDDTEFSLILAEEKKYGELKSGNKKTIVKDLSEESRKQIYQKAKEDLQRKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEB6</accession>
    <name>A0A6P8HEB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-dependent kinase 2-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554061.1">
        <property type="nucleotide sequence ID" value="XM_031698201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEB6"/>
    <dbReference type="FunCoup" id="A0A6P8HEB6">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="GeneID" id="116291088"/>
    <dbReference type="KEGG" id="aten:116291088"/>
    <dbReference type="InParanoid" id="A0A6P8HEB6"/>
    <dbReference type="OrthoDB" id="17066at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023250">
        <property type="entry name" value="Cyclin-dep_Kinase_2_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02040">
        <property type="entry name" value="CDK2IP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554061.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27147" checksum="15671A3FD87ECC03" modified="2020-12-02" version="1">MASKGKSPKTPKSKSSNKRESFTPSPSQRDFPRSRPTCDVAKRVRDLCATWHELVQKWTNLNSLGTTVANKLMNLQLQKQYSDLEDSNSVTVMNDMSQTASSDFEEQVLKTLEELSKILSKMAEIHKKMESLTKSFQAAEKLKQFKEKEDLFDHETETVFNTWPVNEYYSSSEKLHTMFGKELELKQKIFPYFTKTNDRNILLVYLSLWLHEPYLSDEKDVLLESMLIETELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF21</accession>
    <name>A0A6P8HF21_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116291910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031555004.1">
        <property type="nucleotide sequence ID" value="XM_031699144.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291910"/>
    <dbReference type="KEGG" id="aten:116291910"/>
    <dbReference type="InParanoid" id="A0A6P8HF21"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028514089" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="29"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555004.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="40863" checksum="7D2BE3D45CD39216" modified="2020-12-02" version="1">MELVLSKPKVILLSLFMFHAVSLALGRNDTRVLTQQGYVRGVRQVIQTNRGQAKTIYKFLGVPYARSPIGNLNLRFKPPQALSTQRSSDYNATFLRPVCVQDNVTLASIRRAWPTFXPMRDMDEDCLYLNIYTPRTRGTTKYPVIVYIHGGSYISGTPIRDISPGEYLPTRDVVLVTVQYRLGPFGFFSTGDSEAPGNVGLLDQVEALKWIRDNIGVFGGKKSSVTVLGESAGGSSVGLHYLSPQSRGLFHRGIAVSGVDLSPFAYAPKSQVLHSSKELIRMVNCTRNSSQLVVQCLQTVSTATVFKISNPLILKPFVNHHFLPDNPKILRKQGKFLKFPLIAGFVSQEGSFIVEKGGAAINDNTSFTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHD6</accession>
    <name>A0A6P8HHD6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Tetratricopeptide repeat protein 28-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116291326</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554357.1">
        <property type="nucleotide sequence ID" value="XM_031698497.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554358.1">
        <property type="nucleotide sequence ID" value="XM_031698498.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291326"/>
    <dbReference type="KEGG" id="aten:116291326"/>
    <dbReference type="OrthoDB" id="5965416at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="610"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="810"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="891"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="1226"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554358.1"/>
        </source>
    </evidence>
    <sequence length="1510" mass="169732" checksum="F986DBF669BC22B0" modified="2020-12-02" version="1">MDESTLTAFVRCCMHYVLDGCLNLSKQQMICLLKECLIFAHHFEDGLTVMNLNLVLGELHEKMCLFKEALAYYETVLEIAAAAKDKEAERIVLEMAGTIYFIQYNYSQALLKFEKSLNIAIDEGDKDAEEQAYRTIGNVYFTMRNLPEAIRYYEKRLVIVTELGDKKGEGETYTNIGKAYSLLDKDEKAVEYYKKSLDIAIERGDKKVEGTIHASIGDVYTKLSNYQDALNHLETSLNIAQSISDEDLEATSYRSLGNAYLPMKEYEKAITCFEKSLNIALEIGDKEKTGAVYMDLGRTHVLTKKLVEAIGYYEKALKLTQEVGDKMNEGKIYLKIGNIYSSLCQYEEAVEYHKKNLIVAMKIGNEKGMMVSHFNTGRAYLDLHKYHEGILHLEESLKIALDVKEKEIQREIYMNLGDAYKSLGKYQDSIDYEKQALEIIKEFGCKKDEQRTLKKIGDAYMSLRDYSQAIENYELNLKISLELGDKKEARSIHVNIGNACLSLGKQTKAIEHYEKSLEITMAIGDKRAEVKTYENLGKANLELGKTTEALENFKKGLNIATELREETEEGASYVNIGDVYFATGEYREAVEYYKKGESIALTTGNTHLKEIICNNLGSVYFSTSDYTQAEEYYKKSLENAQEIGNMKGEGRTVMNLGNVCFSLGKYQEAIEHHERAVGIAMKIGDKNGEATALVNLAKVLSTRGKYHDAIKYSLKSLVISLNINNKKAEETAYMNLASAYMSLGRYTEAERYVTMAMKIAREIRDKRGEGTCNIILGNVYLTLGKFQDAIMKYKEGLAITTEIGEKNGEGMAYMNLGNTHLYLKEPDKAIDYYQKSLKIAQEIGNKNGEGTSFMNLGNLFSFLLDDDKEAVKYFEKSLEVAKTIDNKKGEGTTYLNLGNAYFSLQKYQEAFKFYEMSVNLAIKMSDKRNQAIANYSLGELCYELSGKYEQSSEDFKQQSINYLKKSVQSWEWVIENLQKRDDFMISIIDQFSGTYNMLTEALNEAGNTEEALLVCDRGRARALGDHLASKYCINLTVSTPLEMTDLEAVSLKCKACIVYFAFLRKGLGIWIIRKENPLFFIALDDQFFNFSTQMLWFKTLGRKENLPFDKVLNDVYSKMQVKEPAKCENRSLDPPATFRQISSHGQNTTDEGSSTERNVTPIDEGSSTERNITTTDEGSSTERNVTPTDEGSSTERNVTPTDEGSSIERNVTTTEDEPTSEPQADPLETLFSHLIAPILQQLKEEEIIIIPDRSLFKVPFAALRDPITENFLSETKCIRIAPSLTTLKYLQECPADSHCETGALVIGGPHVGEVIFKGEKTVMKTLPSAEHEAKVVGNMLNVTPLTGSEATKEMVKKNLRDVGVIHIAAHGDSENGYIALSPPPRIHETSIPDEQDYMLTMQEVQEIGVKAKLVVLSCCHSGSGDIKAEGVVGMSRAFLAAGARAVVASLWAVDDETTFNFMATFYTFLKMGESASKSLQIAMDDIRGEFEDPKDWAPFFLIGDDVTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIB1</accession>
    <name>A0A6P8HIB1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable S-adenosylmethionine-dependent methyltransferase At5g37970</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554663.1">
        <property type="nucleotide sequence ID" value="XM_031698803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIB1"/>
    <dbReference type="GeneID" id="116291620"/>
    <dbReference type="KEGG" id="aten:116291620"/>
    <dbReference type="InParanoid" id="A0A6P8HIB1"/>
    <dbReference type="OrthoDB" id="1890922at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554663.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42336" checksum="234F6ED082704A84" modified="2020-12-02" version="1">MMLRLAQPSKSLIRVLVTKESTMEQKKPFVPHSHLPYGEVGSGYFSTRSIANRQVVKTATPLVLRELDAMALEKQSVVTLVDYGTADGGISMDLIYACVKAIREKYGAELPINVIYEDQPVNDFTSVFLRTQGLVPGPRSYLLDFPNVFVMASGTNFYDQCFPNDSVTLGFSSNCTHWLRDKPCDITGTIFPLFTTVPQEKEKFRVQAEKDWELYLTKRAAELRPGGSMILAEVVLTEDGQFPGHTNDSKYGCMTLLSTLWKSLSDDGVITDDVFTKTNLSLYVKTVDDFKKPFKCPNSPVVKAGLELVSIDTKITPCPYKGKWIKEKGDAKEHAKKYVGSIRAWSNSTFLSGELMVAISRPVRPFCYLDIIVNVNCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIS4</accession>
    <name>A0A6P8HIS4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116291703</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cell membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554773.1">
        <property type="nucleotide sequence ID" value="XM_031698913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIS4"/>
    <dbReference type="GeneID" id="116291703"/>
    <dbReference type="KEGG" id="aten:116291703"/>
    <dbReference type="InParanoid" id="A0A6P8HIS4"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 15" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="829"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="643"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031554773.1"/>
        </source>
    </evidence>
    <sequence length="867" mass="95858" checksum="0370FB6EF99ED572" modified="2020-12-02" version="1">MESFKNMVPLEATILRDGVKVKKNSQEVVVGDIIFIAFGDRIPADVRVLESKGFKVDNSSLTGESEPQARGPECTNQNPLETKNLGFFSTNAVEGTCTGLVIQTGDSTVMGRIANLASGLDTGKTPIAVEISHFIHIVTGVAVSLGVSFFVISLILHYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNKIVEADTTEDQSGVVMDKSDTWYALCRIAGLCNRAEFAVEAEDKPVLKRDTMGGNASEAALLKCVELQVGNVHHMREKNPMVAEIPFNSTNKYHITIHEIDDPEENSHILLIKGAPERVLDRCSTILLEGKEQPLEDDMKEAFEEAYLNLGGLGERVLGFGHYFLSKEKYPKGFEFATDDPVNFPLENLCFVGLMSMIDPPRAAVPDAVSKCRGAGIKVIMVTGDHPITAKAIARGVGIISEDTETVEDISIRLNIPVEEVNPKDAKAIVVHGGELKNIEQGHLDDILRDHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKRADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLMFIVVGIPQPLGVVTILCIDLGTDMVPAISLAYEAPESDIMKRRPRDPKKDKLVNERLIAMTYGQIGFIQALGGFFTYFVIMGENGFLPERLIGIRIEWEDKNNHAVLDNFNQEWSYHQRKILEHTCHTAFFISIVVVQWADLIICKTRKNSIITQKMTNNKLNFALIFETLLAIMLSYTPGLSHGLNMYPLNATWWFPAMPFSLLIFVYDEIRRYFIRKWPGCWVEQETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKN3</accession>
    <name>A0A6P8HKN3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING finger and SPRY domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556351.1">
        <property type="nucleotide sequence ID" value="XM_031700491.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HKN3">
        <property type="interactions" value="1174"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116293095"/>
    <dbReference type="InParanoid" id="A0A6P8HKN3"/>
    <dbReference type="OrthoDB" id="10017393at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF6">
        <property type="entry name" value="RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031556351.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="54481" checksum="5046588130D1733D" modified="2020-12-02" version="1">MGVCCCKSHDNFGEDHNDGEEVNSPERRRYGRKRPQNLGGTDSLVLEALTALRKLADSDEEPPECMIVLHYLAEEDDGWLTIVKSCIFAIPLEDSLGTAXLSFLLDECPLPTKDGINSLITRLDLSKDTTLLKLETKMDTRESPLTPAICRNLAVVLACLADKLAGPMSIALLSPGNLEFLLERLNVKEHPAVILFSILALEKFAQTSENMKTIKETDIAERLLVIEKEFLKSINLLEHQAGFCAQWCLDNSFKYPGRVFSYKNVDVSDIKAMLNSNDVSEYLKISPTGLEVCYIMLLVKIHRFQEGYGIGDDECSYAYDGCRQLIWYNSGIWDVLGLLLDLDRRKIQFSLNGYYFEKDFKPALSKSGFFAAASFMSFQHCIFNFGSEPFKYPPCTVPFKCFNDYAILTEEDKIILPKHIRMAAMKTESILGDPCKICFEKVIDTILLPCQHRDLCMTCALKVEHCPICRQHISKRIPKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMX4</accession>
    <name>A0A6P8HMX4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sister chromatid cohesion 1 protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557061.1">
        <property type="nucleotide sequence ID" value="XM_031701201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMX4"/>
    <dbReference type="GeneID" id="116293742"/>
    <dbReference type="KEGG" id="aten:116293742"/>
    <dbReference type="InParanoid" id="A0A6P8HMX4"/>
    <dbReference type="OrthoDB" id="5982753at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF72">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557061.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17583" checksum="759B4BB29F95D16F" modified="2020-12-02" version="1">MFYSQNILTRKGKLGIIWLAATYKGPKNKYLSSKDFKKVNIIRACEYIMHPTLPFALRLSSTLLVGVVRVYREQTRIILIEANEMVKAVSSAIAEKRLSKELQMASPEQKRDTITLPLLLDYDMEFPECQEQIHTDHLVAFAKVCIHKSLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ43</accession>
    <name>A0A6P8HQ43_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">THAP domain-containing protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116291732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554800.1">
        <property type="nucleotide sequence ID" value="XM_031698940.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291732"/>
    <dbReference type="KEGG" id="aten:116291732"/>
    <dbReference type="InParanoid" id="A0A6P8HQ43"/>
    <dbReference type="OrthoDB" id="5971057at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031554800.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17430" checksum="F6D424321067FC00" modified="2020-12-02" version="1">MASVSGGYTCCVPGCFNNNKRDKHLSFYKFPKDKKLRKLWLNNISRKNXSPTAGHKVCSQHFQGGKKTYLNNIPVIFPLAKSHKKPTKPPRRKLIRHETRTDQEEVESDIKEVAPEEVEFIDTEESNTVQQEIRGLTIPLSYRMPFVQMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ49</accession>
    <name>A0A6P8HQ49_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="9">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031554767.1">
        <property type="nucleotide sequence ID" value="XM_031698907.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HQ49">
        <property type="interactions" value="1442"/>
    </dbReference>
    <dbReference type="GeneID" id="116291699"/>
    <dbReference type="KEGG" id="aten:116291699"/>
    <dbReference type="InParanoid" id="A0A6P8HQ49"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031554767.1"/>
        </source>
    </evidence>
    <sequence length="792" mass="91675" checksum="C0A4C9F26381C284" modified="2020-12-02" version="1">MAEKTGSRSSARPMLHRQRERTQSVPEGKDCEDLFSFPPETLRRHTLLSSEFQNRPNMKTAKNKKHDVFSTLQETLEVLRDEAGARSRDSHKRDDLWCHPFEIPEHPIGQSEMRRDEIDLERQQSRIMRAGSTTTLDEKMFSSTDGSHEQLPIFYQRLSISGENSSGVPIDELKQASKLLVEALFIRFKYMVLSMQSYCPTLAESLNSVHEDYNLDKFMASRNMDKPKPPPKRDLEFYNYSSHSPFDQEIPGDCGYKVKMVDGVIQVMSSGNSDGSEKKCEVIHPFPDLQEFFDDQNVLFALSTHGPIKSFSYRRLKYLESKYNLHALLNDLKEIAAMKEVPHRDFYNVRKVDTHVHAASCMNQKHLLRFIKKKMKTEGDVPCIKIDGKVATLREVFAMLNLTPYDLSVDTLDVHADSNTFHRFDKFNSKYNPVGESQLREIFLKTQNHINGKYFAQLLKEVFADLEESKYQNAEYRISIYGRSRDEWDNLANWAVEHKVYSQNVRWLIQVPRLYDVYRSKNLVQNFEEVLENLFMPMFEATLNPQSHPQLHQFLTQVIGFDSVDDESKGESHLFSQNSPLPANWTSEDNPPYSYYLYYMYSNMVCLNHLRREXGFNTFKLRPHCGEAGPAHHLVTAFMLSENISHGLLLRKVPALQYLYYLAQIGIAMSPLSNNSLFLNYQRNPLPEFLSRGLLISLSTDDPLMFHFTKEPLMEEYSIAAQVWKLSQCDMAELARNSVLMSGFEDEVKHQWIENATGGNDITKTNVPNIRVAFRQETLTEELKTICEGARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ64</accession>
    <name>A0A6P8HQ64_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116294294</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557721.1">
        <property type="nucleotide sequence ID" value="XM_031701861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ64"/>
    <dbReference type="GeneID" id="116294294"/>
    <dbReference type="KEGG" id="aten:116294294"/>
    <dbReference type="InParanoid" id="A0A6P8HQ64"/>
    <dbReference type="OrthoDB" id="6138359at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028266434" evidence="2">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557721.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16570" checksum="E79F6796D1640D4D" modified="2020-12-02" version="1">MKTLMLLAAICLVLCVVLPQNDAYCIRYRSTSCGLTYISGCGWYRICVAYYNTNCYTKRDEIENDKATNKKGPGKAILEDMPCKFSTYDKNDDGSITFDEFRSTLADVHGIKQIMKAFRGSDTNGDGVIKCNEFKKSEWGCSHKHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRF3</accession>
    <name>A0A6P8HRF3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCY1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557688.1">
        <property type="nucleotide sequence ID" value="XM_031701828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRF3"/>
    <dbReference type="FunCoup" id="A0A6P8HRF3">
        <property type="interactions" value="2737"/>
    </dbReference>
    <dbReference type="GeneID" id="116294267"/>
    <dbReference type="KEGG" id="aten:116294267"/>
    <dbReference type="InParanoid" id="A0A6P8HRF3"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000179">
        <property type="entry name" value="SCY1 like pseudokinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557688.1"/>
        </source>
    </evidence>
    <sequence length="635" mass="71504" checksum="B6AD4BEC76F25F51" modified="2020-12-02" version="1">MEKYTGAMFDKLDKLKSAAMNATVTAYCATKSAVGAVGALIGNPLTKDYEVGKHVASFGPNLCWKIFDGKRKSTGQEVSLVVFEKKTLDSIDKHDRPAVLEVMKKGAVQLTRLRHPRILMIQHPLEESKDCLAFATEPIFASLANVLGRHENMPNPPNPDFATFEMYDVERVYGLYQLVEGLTFLHNDAKILQGSLNPEHVVITKNGQWKISGLFFSSTPTIIDGQSTYSGCQWEPRLFPYAQPDLNYCAPEYILSRSCDVSSDMYSLGVLIYALFNGGKTPYSCDNNMTAFKRNVELMSRESLPGLGGVPPELKSHVTSLLSLTCALRPDVHQMAKISYFENVAALTLQYLDSLMQRDDMAKAQFFKSLYKIMSKLPKRVIIQRVLPQLCLQFSNHKLVPFVLPNVLLITEDCTTDEYVRLILPELKPVFKIQDPIQVTIIFLKKLELLLSKTPSDSIRDDVLPMVFRALEAPSTDIQEMVLNIVPNFAPLVDYTLMKNSVIPRIKTLCLQTSSLAVRVNSLVCIGKILEHLDKYVVMEDILPFLAQIPSREAPTLMAMLGIYKQTMIHKKLGMDKDYLAMKAIPFLFPLSIEPSLNLKQFSQFMDILNDMVKRVGVEHKAKLEQLGKMQEQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRM7</accession>
    <name>A0A6P8HRM7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rho guanine nucleotide exchange factor 28-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555300.1">
        <property type="nucleotide sequence ID" value="XM_031699440.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HRM7">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="GeneID" id="116292176"/>
    <dbReference type="KEGG" id="aten:116292176"/>
    <dbReference type="InParanoid" id="A0A6P8HRM7"/>
    <dbReference type="OrthoDB" id="28045at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13329">
        <property type="entry name" value="PH_RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000004">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="827"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="584"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1295"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1376"/>
            <end position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555300.1"/>
        </source>
    </evidence>
    <sequence length="1401" mass="157460" checksum="7FA676EEA02F9AD6" modified="2020-12-02" version="1">MSSSTTDSSLQVTSSKTEACCMAFTPQSCPTKGGELVFITYSDDFPLPKEAEFFLVFEGCSEVHVTTSQQINRYTLRAVVPDHATAERVSLTVYCLKNDVLGILSSHTFLYYLETEHILAELLAQNISDSKFLESLVPLCSSVSNNVSCNLREALDFRITNAFELLDFSPSWTILGDESDEVDNGFETTLLHLSAHLGFSQFASFLMDHPGASHALEIQDRNGKLPVDIAKDKGLQTLVDVFLRGAVEKNAKPKSKEISKSRVTKSEIGTTTISHTRTDQENVIEKDIEMLREMNNLVKEELSKRIPIFMHLWPVNKNENQKTERGSTTNNNEHAGKKDIKSQCRIPGSNRLLLEQNLKRLRDINEEIQRLRVTSQRNHRETGTKGPADRRQMRRLSCPSFRGQDITQAHMIIGKPVKQEERPPSDKMAGMINTKNEKEISCNSINEDLDKSTYLDVDDSSDMRRRSWGEKIKDDGKSGFHDRVSSSLDDLTSTEYIRKTREPSRSRTQVIDLPKHLTKEEESNKLADIIDSIKHSQEETPNHEKFHKGSSSRNANIVSMQGKSYSYSCLANLKLDDSVDSGDGGAINAGGETASPDTKTSRDEKISLLDFLDNPDDSEDSEEPTKEQDKPQQEKGLRRLSMLFGGSKSAKHGKRELPKAGHSKPSXRSSMRKEKGQSMTNLSVKDADLRGESKENKDSGSKTALARRASGLSQKGYRAGEAPTFPNPGMLTKMGNHGNKTVAASHSSKSTSPLPFRRSLNPSQDEGDDKSMSGVSLEGSGDEDDEEGVFTGEGWTDSDLDMKEEPDAWNLTVDKKILKKMTAKEIKRQDVIHELIQTEVHYVRTLKIMXKIFYGGMINSLHMSKGTVDRMFPQIEELLDIHTWFLTRLREKEDEETIVEKVGDVLEEQFSGQTGERIKNAYGEFCSHHIEAVDLYKKKLKNDKRFADFVKRCSVNKMCRRLSIPECITLVTQRLTKYPLLFEAIIKTTKESKQDYGSLKKALELVKGVLHAVDDAIKEYEKQKTLQDIRMRMDLKTVITYKDGKEVMNIDFASNTSTLRYHGMLFWKTARGKLTESLVVILEDMLVFLQEKDQKLSLLSLDQKAPVIRLNNLFVREVATDTKAIFLVSTSKDGPEMYEMVCNTASEKRTWIMNLRDAIQSAPKDDGTGELITTAAGEKRKLIMRRAEAILEQIQSKEVEDQEKCLPEIQELITQLETEEGNVKGRTRKELAKTRESLTQVMNQVHASRSSIEESQCNETTSTSGDPDEVGFKRAVTFSTFDNKLKPVXAEQAVNRAQSMKTERTGRSYNRQLPGATAASSPDTGSPLTKHKRKGSGGSGKGWSIRSKSKDDKETSETKVDQATSFXPVNMPCQEQDQDDNECLPDQEDCTDKPTPDVIXF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSM7</accession>
    <name>A0A6P8HSM7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559379.1">
        <property type="nucleotide sequence ID" value="XM_031703519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295639"/>
    <dbReference type="KEGG" id="aten:116295639"/>
    <dbReference type="InParanoid" id="A0A6P8HSM7"/>
    <dbReference type="OrthoDB" id="5983006at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="2">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559379.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="25515" checksum="214C545B927CB603" modified="2020-12-02" version="1">MEGHGFDEFNYSEELEPIATEEEYVVYQRELEIELEEEEMLKKRFAKEIQLNHWCSCSACSLTLITNQAECFCCQDIDRCREKLEDFEEELPCITEHPGFRSICLDKWVLETAAIGLKTRKRRSYVVMREQGLVPEARFFRSVAYRQFYRLIWEYDGNLRRLPLPCCVYNAIRSEFPSEHGTYKGFXEEDEEEEETNTDSESEDEELQFDEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTP9</accession>
    <name>A0A6P8HTP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome non-ATPase regulatory subunit 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558598.1">
        <property type="nucleotide sequence ID" value="XM_031702738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTP9"/>
    <dbReference type="FunCoup" id="A0A6P8HTP9">
        <property type="interactions" value="2222"/>
    </dbReference>
    <dbReference type="GeneID" id="116295039"/>
    <dbReference type="KEGG" id="aten:116295039"/>
    <dbReference type="InParanoid" id="A0A6P8HTP9"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="250"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558598.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="53731" checksum="130D2CE0BF394BA7" modified="2020-12-02" version="1">MAKDEDFKMAGTTITDMKGNVVKMEVDYSDTVDKTIPQCEKLAEEGKLTEALEILLSMEKQTRTAADMHSTSRVLICIVQLCFKNKDWNALNENISILTKRRSQLKQAVTKMIQEAYGYVEQMPDKETKLKLIDTLITVTAGKIYVEIERARLSRMLAKIKEDDGDISEAANILQELQVETFGSMERKEKVEFILEQMRLCLAKKDFVRTQIISKKISPKFFENDQEQELKLKFYQLLIELAGHEGSYLATCKYYKAVYNTPIIMEDKDKKHQALRNVVLYLVLAPFDNEQSDLIHRVKEDKVLEEIPLYQELLKCFTTSELMDWSTIQQLYGEELRKGTGKTVFDTASDDGNKRWEELRKRVVEHNIRVMAKYYTRITMKRMSELLHLTPEESEHFLSELVVSKTVFARIDRPSSIVTFSSSKQVNDILNEWSHNLSKLMGHLNKTTHLITKEEMVHKLSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTX3</accession>
    <name>A0A6P8HTX3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Carboxypeptidase D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116296015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559839.1">
        <property type="nucleotide sequence ID" value="XM_031703979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTX3"/>
    <dbReference type="FunCoup" id="A0A6P8HTX3">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="GeneID" id="116296015"/>
    <dbReference type="KEGG" id="aten:116296015"/>
    <dbReference type="InParanoid" id="A0A6P8HTX3"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000004">
        <property type="entry name" value="Carboxypeptidase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF73">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027610738" evidence="11">
        <location>
            <begin position="21"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="105"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559839.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="60651" checksum="7F6CFE6DE3E919C6" modified="2020-12-02" version="1">MRCLKVLALVLCVHALTTFAKPPASLSKKSSAKVVKKSPTKSPIQHLAPVKPELKAKVRAVKQKVTAVKQQKHVVHEQKAAKEIPTKVVPKIKVEEIHEKNSSFRHHNYEEMTWLLKEFARKHQDIARLYDIGKSVQNRKLWVMEISDNPGKHEAEEPEVKYVANIHGNEVIGKEMLLHLIRYLCHNYGINKRVTNIVDATRIHILPSMNPDGYEMAATDDDHQAGSKNANDIDLNRNFPDQFFPSTTGPPQPETHAVMKWVRSNPFVLSASLHAGALVASYPYDDNPSGKTSYSASPDDDVFREVARAYSQAHPTMHLANAPWKCKNKQKEHFIDGITNGADWFSLSGGMQDYNYVHSNCFEVTLELGCEKFPNATALPEYWRENKEALLSFVEQANKGIHGIIQDEDDKPIKDARINIANRPHDVFTSNKGDYWRLLVPGSYEVTVSAKGYEHESKTATVHSSAATKLDFTLRRIRERKPRHIEDNEDPRGSFTLRRSLRDFYRDESPDQKKQNYDGDDDNDYGARRQVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTY4</accession>
    <name>A0A6P8HTY4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="7">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116296027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031559849.1">
        <property type="nucleotide sequence ID" value="XM_031703989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTY4"/>
    <dbReference type="FunCoup" id="A0A6P8HTY4">
        <property type="interactions" value="946"/>
    </dbReference>
    <dbReference type="GeneID" id="116296027"/>
    <dbReference type="KEGG" id="aten:116296027"/>
    <dbReference type="InParanoid" id="A0A6P8HTY4"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000002">
        <property type="entry name" value="Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="8">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559849.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="56489" checksum="D6B0023E1AF2E482" modified="2020-12-02" version="1">MAGIVWCSSRRICRRLDHRIFTPNKLRFSTSCSKLARFYDSPDEAIKDVPSNSKLLVGGFGLCGIPENLIDALQRSGVNNLTCVSNNAGVDTFGLGLLLKTKQIKRMISSYVGENAEFARQYLSGELEVELTPQGTLAERVRAGGAGIPAFYTPTGYGTLVHKGGAPIKYNQDGTVAIASKPRESRDFNGRHFIMEEAITGDFALVKAWKADKSGNLTFRKSARNFNAPMAKAAKVTIAEVEEIVEDGEIPAEDVHVPCVYVHRVIKGEKYEKRIERLTLTKDDNGKNEAKSLALEFRERIIKRAALEFKDHMYANLGIGMPMLASNYIPEGMTINLQSENGILGLGPFPRPGMEDPDLINAGKETVTVRPGSSFFSSDESFAMIRGGHIDLTILGAMQVSQLGDIANYMIPGKMVKGMGGAMDLVSSPSKVIVTMEHTAKGDKHKILEKCTLPLTGTECVNMIITEKCVFDVHPEQGLILKELYPGVSIQDVQTSTGCGFEISPDLKEMGQIGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUJ7</accession>
    <name>A0A6P8HUJ7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558948.1">
        <property type="nucleotide sequence ID" value="XM_031703088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUJ7"/>
    <dbReference type="FunCoup" id="A0A6P8HUJ7">
        <property type="interactions" value="1544"/>
    </dbReference>
    <dbReference type="GeneID" id="116295306"/>
    <dbReference type="KEGG" id="aten:116295306"/>
    <dbReference type="InParanoid" id="A0A6P8HUJ7"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558948.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35011" checksum="0075EB1E413C131B" modified="2020-12-02" version="1">MADEVKKKEVCDEELDDLLDSALSDFDKPAVPPTKKANSEALDERKTNDETTDQKASGTATHSADNMTPSSTTTGADNTMPSEDELSKIFATSFADAAADLEKAMKNMGGDYDQDFVSHLNKLAESAKTAAVQEHPEAMGAFEENLAKTMSDMAQNTKDLENCGPDLLGDDLLKAMSGMGVDGSGEFDMMPLMQGMMKNLLSKEILYPSLKELNEKYPEWLESNKSKHSSEDHGRFTRQYQFVGQLCQEYESEKPDDTDEVSKKRFEKIMELMQKMQECGQPPEELVGQNIAGPFPPEMPAGMPEMPADLQDQCKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVR8</accession>
    <name>A0A6P8HVR8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Galanin receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16 17 18 19 20 21 22 23 24" type="primary">LOC116293246</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556542.1">
        <property type="nucleotide sequence ID" value="XM_031700682.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556616.1">
        <property type="nucleotide sequence ID" value="XM_031700756.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556687.1">
        <property type="nucleotide sequence ID" value="XM_031700827.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556757.1">
        <property type="nucleotide sequence ID" value="XM_031700897.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556832.1">
        <property type="nucleotide sequence ID" value="XM_031700972.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556898.1">
        <property type="nucleotide sequence ID" value="XM_031701038.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556974.1">
        <property type="nucleotide sequence ID" value="XM_031701114.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557046.1">
        <property type="nucleotide sequence ID" value="XM_031701186.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557118.1">
        <property type="nucleotide sequence ID" value="XM_031701258.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557195.1">
        <property type="nucleotide sequence ID" value="XM_031701335.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557264.1">
        <property type="nucleotide sequence ID" value="XM_031701404.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557337.1">
        <property type="nucleotide sequence ID" value="XM_031701477.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557412.1">
        <property type="nucleotide sequence ID" value="XM_031701552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVR8"/>
    <dbReference type="GeneID" id="116293246"/>
    <dbReference type="KEGG" id="aten:116293246"/>
    <dbReference type="OrthoDB" id="5952899at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000401">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031556687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031556757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031556832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031556898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031556974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031557046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031557118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031557195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031557264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031557337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031557412.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40532" checksum="3409ABDEA5C435F2" modified="2020-12-02" version="1">MNVSTNATSTVPPLPSGYLAVRYTRLVLYPVIFAIGVVGNSIVSALILKKSKNSTANGYFILNLAISDLMALLLYLPFDLAYLENHYEWPFGAFMCKFINCLNKFSVMVSGLTLVAIGVDRYKAIVHSLKKRLSRRDAMIMITVIWLFSAVLQLPYVFALKLDPRGECVIDLSFWKGPYQFEMTYFFGVFTPEFVIPAIALSFCYVRISIHLEQTHKRNSKHGLFQESTMTLRERQNRKTTQVLTGLVTIYTICILPHQICVLMITFQRNYLNSDIMRLAYEFTRLLTITNSCLNPIMYGAISKGFRTDIRNFFRGKHAQTGSFRFLRSTHSRSPETKNLKDIMYNQENSFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVR9</accession>
    <name>A0A6P8HVR9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM and LDL-receptor class A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559471.1">
        <property type="nucleotide sequence ID" value="XM_031703611.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HVR9">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="GeneID" id="116295706"/>
    <dbReference type="KEGG" id="aten:116295706"/>
    <dbReference type="InParanoid" id="A0A6P8HVR9"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF142">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028294543" evidence="1">
        <location>
            <begin position="22"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="41"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="223"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="395"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="576"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="744"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559471.1"/>
        </source>
    </evidence>
    <sequence length="913" mass="101775" checksum="EF3A337D9037D8FD" modified="2020-12-02" version="1">MQLSCVVLGFLVLCLFEVVFAAPSGNGGKVDPLAGTFGINGNCSFDTNLCNWVNARSGDNFDWTLRRGSTPSANTGPVRDVSGRGKYIFIETSNPRKKGEAATLISGPYIGVLCMQFYYHMRGSQIGDLRIYMSERGPVGQKLIWTKEKQQGQFWKRENVTVYGFAFDILLEARVGGGYEGDIAMDEITFTPGTCYPNENREKLLKSRSSAQEDGLDNSTTKGSCDFDSSLCGWSNDIMNDDFDWTLSAQPTDTKGTGPAKDHGGKKGGRFMFIEASSPRRSGEKARLLSPQLCGQVCLRFYYHMFGVGMGNLNILRKEGINGKGDRIWYARGNWGTKWHRAVAEMNSDQHCYQVIIEGIIGTTYTSDIAIDDVYVQKGSCCEMTSELNRLDFTGNCNFDKSFCGWTNLKNDDFDWSLGKGKTPSDHTGPSKGFGKTDGYAFIEASEPRIGGDTAIMASGYLLGSMCMRFRYHMYGEDIGSLSVFRNGDGVKXQLLWQQDGNQGNTWNEVEIAIDCXVTRYLVEIEASVGGWRGDIAVDNIKFTPGACPPKPVIIKNINYTTAAPPVISKLPDFDGFCNFGRGFCNWENDVDDYCDFYRQRGPTATLNTGPYKDFSGDGYYIYLEASSRRPGEFARLVSGSIKDTKCLKFYYNMHGEGVGDLRVDLRESENFIWNTTWSVSGDQGLNWNPIALTISGKDYVIGITAVRGRNFIGDIAIDSIALTPGPCFDNELEVGAAQSAKLVDCTFDKRDMCDWRNEKSDDFDWTIQRGRTPTGNTGPGRDRSGNGYYMYIETSTPRRPRDKARMIMEVSQDVCMTFFYHMYGADIGVLTVYQKEGSSDYARETVKWKKVGNQDNRWSDASISFTAKGKGSYWIIIEGTRGRSYQGDIAIDDITFKPGPCAGRWRQYQNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX45</accession>
    <name>A0A6P8HX45_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">DNA repair protein XRCC4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC116293812</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XRCC4 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557151.1">
        <property type="nucleotide sequence ID" value="XM_031701291.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557152.1">
        <property type="nucleotide sequence ID" value="XM_031701292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293812"/>
    <dbReference type="KEGG" id="aten:116293812"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22283">
        <property type="entry name" value="HD_XRCC4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010585">
        <property type="entry name" value="DNA_repair_prot_XRCC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053962">
        <property type="entry name" value="XRCC4_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053961">
        <property type="entry name" value="XRCC4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009089">
        <property type="entry name" value="XRCC4_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28559">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28559:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06632">
        <property type="entry name" value="XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21924">
        <property type="entry name" value="XRCC4_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50809">
        <property type="entry name" value="XRCC4, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRCC4 N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="XRCC4 coiled-coil" evidence="9">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031557151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557152.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37450" checksum="CBEE36A512F76D21" modified="2020-12-02" version="1">MEDLCRIEAKDQTFFLVTKTLNEGKDGFKLTLCDGEQVWRRTVSKEEVQCMAEGVDMSIGXYVEQSIGALTQQSLHKASFVYDVLKQDHNLQFSWKKKLEDGVKFQMGSVMLTKEEDCRKSMIEILSLAVNHITHHKEEISSLKSENSRLSNERKSAMKLLEKCTTAKDEMEKDLFEKFAAVLNQKKAKIRQLQSQVSEYAKDMTDAGQKKKKPRRRSLSESESAGSRTPSPCPEDTSQGATAEESASNAATPLFLAEDEEKPMEMNTRRRIRRGPKKETPRSKLVLPKVPAVKKTPSSSSEDSLSTPRLRKRTKEKPSLDPDELMAEMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYZ4</accession>
    <name>A0A6P8HYZ4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial thiamine pyrophosphate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116294430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>thiamine phosphate(out) + thiamine diphosphate(in) = thiamine phosphate(in) + thiamine diphosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:73383"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557885.1">
        <property type="nucleotide sequence ID" value="XM_031702025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYZ4"/>
    <dbReference type="FunCoup" id="A0A6P8HYZ4">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="GeneID" id="116294430"/>
    <dbReference type="KEGG" id="aten:116294430"/>
    <dbReference type="InParanoid" id="A0A6P8HYZ4"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="128"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="230"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557885.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38722" checksum="907A0D62BC23F933" modified="2020-12-02" version="1">MVGFDPSRVEKGLTSSQCGYCGSFAGAVTRVFAQPLDVLKIRFQLQVEPTSTNHLLMSRKGEKPTGKYTGVSQAFKLVYREEGILALWKGHVPAQILSIAYGYFQFTFFEAFTQIAYFISPRLLEQRHKPMTHFICGGISGCAASFAIQPLDVIRTRLVAQGEPKVYSSMIEAARMMYTLEGPTSFYKGLIPSLLQIFPYAGLQFGSYTLLKMIWDYTFDIRIHDPYMPADIIESLFCGAVSGMISKAVILPIDIVKKRIQIQGFAVHARAHFGKVPEYHNLRHCVRSIIKHEGVQGLYKGLVPSTIKAAVSLSITFSAYEQCLHFVRHLLHKDAAIKDLSPPASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ11</accession>
    <name>A0A6P8HZ11_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116296728</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560658.1">
        <property type="nucleotide sequence ID" value="XM_031704798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ11"/>
    <dbReference type="FunCoup" id="A0A6P8HZ11">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="116296728"/>
    <dbReference type="KEGG" id="aten:116296728"/>
    <dbReference type="InParanoid" id="A0A6P8HZ11"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22709">
        <property type="entry name" value="FHA_KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000063">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000034">
        <property type="entry name" value="kinesin-like protein KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="4"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="860"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="409"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="876"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031560658.1"/>
        </source>
    </evidence>
    <sequence length="994" mass="111650" checksum="E2F0F2FFE0AB4578" modified="2020-12-02" version="1">MAENVRVAVRVRPFNSREKARNAKLIINMIGNNTEIRDPEAPNAEPKKFAFDFSYWSHDCFKEQDNGYLEPTDPKYADQKMVFDDLGQGVLANAWKGYNCSLFAYGQTGSGKSYSMVGYGANKGIVPIFCETLFKEIDEKKNSGVKAEFQVALSMLEIYNEQVRDLLNPASNKKGGLKVRQHPNKGFYVESLVTVPVKSYADIDNRIEEGTKSRTVAATNMNATSSRAHTIVAINFSQKSKNEAGQNMTKTSIVNLVDLAGSERAESTGATGDRLKEGSAINQSLSMLGNCIKALADQSSGKKNVLVPFRDSVLTKLLKNALGGNSKTIMIAALSPADINYEETLSTLRFADRAKAIKTKAVVNESPTDKLIRELREENARLMEQIKKGGVVYVQGEAPEQQQPGGPSEEEMEEMKKEMEEQLKRNQMEMEQMEKSWKERLLETEAAYKAKEEEEKREKEMRITTPHFWNLNEDPQLSNMIVHFIKPGTQRIGNRKADPPADITLSGLSILPDHGSLKCENTTIKIKPSKNAKLTINGKPCTEEKELHHNDRVMFGSSNLFVVHHPTELDKAIQSGGKVEKITFDMAQEEIAQNSGFNMDKTGGKSNDELLLQEDLVKLVPMVNEANAMGEELGKKVKFELMLISPQSRGLKEGRTEVKVKMKSTVDDAEWVWDRNKFSNRKYLMQEMYQNYVEGEEWDKPKEEDPFWEPDDVDVMIGSVQVYLQSLAYKIELEENLAITDHRGDDKGTLQVEIFPCDDKGNEDNDDFVEEPEELVGKNLYFNFKIPSARGLPHRFSKGQTYCSFKFYLDKQASSTGTIENTINPNFGYNKRFSYSPVTKQFLDYLQNQPLVIEVWGKQRGRKVSKVEQPGPKPVPNKTTPPQNTQTPQQPANGGPLAHRTPSLTNEEQRARDLQMTKSIKRADRSEKKLKKIREMVEQAKKNNNTAIPVSEIEDILNGGEGDKFKATASIVMTTNKAAAENDGKVTSAACVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0K7</accession>
    <name>A0A6P8I0K7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin-associated protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562134.1">
        <property type="nucleotide sequence ID" value="XM_031706274.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I0K7">
        <property type="interactions" value="757"/>
    </dbReference>
    <dbReference type="GeneID" id="116297952"/>
    <dbReference type="KEGG" id="aten:116297952"/>
    <dbReference type="InParanoid" id="A0A6P8I0K7"/>
    <dbReference type="OrthoDB" id="10265679at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016939">
        <property type="term" value="C:kinesin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01297">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562134.1"/>
        </source>
    </evidence>
    <sequence length="861" mass="98664" checksum="E6B96D5903EBDAF6" modified="2020-12-02" version="1">MQANEARFLKRRVKGGSVDVHPTENAIVVNYEVEALILGEMGEPMVGERKECQKVIRLKSLNDTTNIGALAKEIIEKCKLIHPTKLPEVEQLLYYLQNRKNSAKNKERKSEQKTLQEAAAVDFEDTEIDEVANINDIDDYIELLYEDIPEKIRGTXLILQISRNPDNLEEIAQNETVLGALSRVLREDWKKSTELTTNIVYVFFCFSSFSQFHSIIIHYKVGAMCMQIMESEIARYSSWTEELDKKKTSNNRKDYEKSYKKFLGLVKKQEQLLRVIIYLLLNLAEDAKVEMKMKNKNIVTMLVKLLERENTDLLIMVVSFLKKLSIFTENKDEMAQSNIIERINNLIPNANEDLLNITLRLLLNLSFDSGLRDKAVKVGLVPKLAHLITNDIHSVVVLCILYHISMDDRFKSIFTYTDCIPTVMKMMLESPGENIELELISLCINLAANKRNAQLICEGPGLKLLLKRAFKFQDALLLKMIRNISQHDGSTKEQFIDFIGDLANAVLKCQDEEFVVEALGILGNLTIHNLEFQQLLIDYGMLAFIKSKLQPGAAEDDIILETIILIGTVSMDDECAAILAKEGIIQTLIELLNAKQEDDEVVLQIVYVFYQMIFHKATRDVIIKETQAPAYLIDLMHDKNTEIRKVCDQTLDIIMEYDEDWAKKIQAEKFRWHNSQWLEMIENRAQMDDDEGFMYGGDEAPYLDGDLLDRQELFYGHPGYDDPVTLMSREGAVSPDFIGGEQGEYLMYEDQRYEGTNGPPVSPYPDRRMMNPYVQVQYPGQEYPNNGYPGQDEGIEDWGRLIGEQSSDEYNPMQDQMVRPGSRYGGRPVSPRYAGDPYEAEETDMYGRPVSRGPRGGYGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1N5</accession>
    <name>A0A6P8I1N5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Cytochrome P450 4V2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116295183</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558794.1">
        <property type="nucleotide sequence ID" value="XM_031702934.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558795.1">
        <property type="nucleotide sequence ID" value="XM_031702935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1N5"/>
    <dbReference type="GeneID" id="116295183"/>
    <dbReference type="KEGG" id="aten:116295183"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558795.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="59609" checksum="6CA69B0B1D40064C" modified="2020-12-02" version="1">METSRSEFWPLILALSVGVPLVFAVWGLMAWKRAKNAMKVLETLPGPKKSFFFGNAMQFKRDGSDFNDQLLQWSKEYQENGYFCLWFGPFHTMIFTFRPDFAELLLSSSRNITKSFLYTFVHPWLGTGLLTSTGEKWKRRRRQITPTFHFKILNVFIQVFEEQSKILVSVLKDECEKGKLDIFPKITRCALDIICESSMGKSVNAQIEGNSPYVNAVLRMSEVLLQRAKSPWLWPDFVFHLSSSGRIHKHCLNMLHGFTNKVIDERLLERKSSAGQEEREVDEFTGKRKKRPLAFLDLLLDAFDDGQIDREGIREEVDTFMFEGHDTTAAAMTWVILLLGQHPDVQNKAQQEVDEFFESRPEQLTVDSMKDLKYLECVIKESLRLYPSVPFFGRKITDDFVIDGVAIPKGETVVVAPMALHHNPNVWPDPERFDPDRFLPENSEGRHPYAYVPFSAGPRNCIGQRFALLEEKVVLANILRHFNVKSEQSRDQIRVCAELITRPQDGIFVTLTPRDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1P5</accession>
    <name>A0A6P8I1P5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptide Y receptor type 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562464.1">
        <property type="nucleotide sequence ID" value="XM_031706604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1P5"/>
    <dbReference type="GeneID" id="116298220"/>
    <dbReference type="KEGG" id="aten:116298220"/>
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    <dbReference type="OrthoDB" id="5955663at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562464.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39005" checksum="ABBB7D28D819C0C8" modified="2020-12-02" version="1">MLLCDAFTRVKPSKDILNVVWMLFHLLGLSANIWAFWLLKKKWNTLGSHKLLLGTSIFSNVFALVVHLYLPINFMLRSVTGLQWSLGSSLCTVLPPIANFALTASILGLLAVAMDNYFKNIHNDEVSSRDAENTTVLVWAIASLLTAPQFCQCGMVSQAYLDAGNCVQGWQYTESGRLYEASRLILQYIIPFAIIGNLFIKVHIYPFGWKNRSKCRRFLSILTDLVTGVFVGAAAYLFPVQTVMASWGRSVNGSPFPDVATVSQVLEFFAVFLCIATPFEFIEILNDEDIKAPCYETDALGEYQPVDQAIKINKGNLSEKIFKEKPSDELLKSLINEEPLRLKNEIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2K6</accession>
    <name>A0A6P8I2K6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295429</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559085.1">
        <property type="nucleotide sequence ID" value="XM_031703225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2K6"/>
    <dbReference type="GeneID" id="116295429"/>
    <dbReference type="KEGG" id="aten:116295429"/>
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    <dbReference type="OrthoDB" id="428577at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000306">
        <property type="entry name" value="Putative ubiquitin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.175.10">
        <property type="entry name" value="Diphtheria Toxin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36649">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36649:SF28">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559085.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37648" checksum="07B6DB7A64D5BD23" modified="2020-12-02" version="1">MSSTLDILGAGFSSILGVDLDNYNIKDLGKPREISIYDLFKQTYVMRPMRVDYNYDCEDQLVVSTLTRKELMIPFVSSSCTIEQVKTMISEKEGIPIDQQRLIYSGEQLMDGNTLKYYGIRPGATLHLVLRLRGGGFTSYKLCADELDPEFDFDFSNMNDDGKTYARGGFEYKRGPYGWKRIAIKVIGRYESDDWLGPNGIRTCEAPNEWPVSYHGTNFANSNSILENGFKAGDRALYGKGIYSSPSLEMVERCYAQEFTQQGKKYKIVFQNRVNPDQLHGNLKVIPASVTGVGADYWVAPKHDTRRGVIDVRPYRILIKEVISESAQCMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3U8</accession>
    <name>A0A6P8I3U8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM and LDL-receptor class A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559470.1">
        <property type="nucleotide sequence ID" value="XM_031703610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3U8"/>
    <dbReference type="FunCoup" id="A0A6P8I3U8">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="GeneID" id="116295705"/>
    <dbReference type="KEGG" id="aten:116295705"/>
    <dbReference type="InParanoid" id="A0A6P8I3U8"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027896398" evidence="1">
        <location>
            <begin position="20"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="76"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="251"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="419"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="597"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="775"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559470.1"/>
        </source>
    </evidence>
    <sequence length="989" mass="111608" checksum="056D53E2928308A2" modified="2020-12-02" version="1">MQLFICLVIICALCQQTVAFPKSNDTTTRASVNSITVVQVTTVRVPTTPSTTSLKLSINDPPTTDSTPIEELPHPGDCDFDSSFCNWTNTVDDEFDWTRLSGRTASSNTGPSSDVTGRGYYAYIEASWPRRPGHVARLISPVTEGVQCMRFYYNMFGRYMGDLQIFIKENSSMVFLWGRYKNQGRGWHSTNVTVYGESYRIVFFARVGKSYTGDLAIDNITFVSGTCDGKPLFYQEKVKDVAVQLAEGEPGTCNFDGGFCEWINVPIGDNFDWTLHRGRTGTGDTGPLYDHAGNNGYYLYIEASTPRLSRHSAQLLSPRLCGTMCMHFYYHMYGSDMGELNIYQRRGLRTDDRIWGARGEQGDVWHETLIDISGNCYQIVIEGIIGNGYLGDAAIDDVVVTKGSCCAKRHLNFDVKKEGNCSFDSGFCKWKNLKEDDFNWSLIDKETPSTKTGPDGPFNSIGQYAYVEASEPRLKEDRAVLVGPVISGFVCLRFKYHMYGQHTGALAVYQHGSGVLRHRLWVRQGNMGNLWRDAYLNIGCKEPHYQIEFEAIIGGWRSDIAIDEITFSHTMCNTTIDVPIPSPPITLPPTLYPLCNGDCTFPGSFCEWKNDRDDQFDWLIGQGSTPSLVTGPKRDVDGNEYYIYIEASLYRYKQRASLVSGYMRGTKCMQFHYHMHGRGIGVLTIQMINTNNNDKKTIWYRAGQQGENWIRTYLNVQGTGYKIAIVGEIGGATTGDIAIDDISFTDGQCKYLLETVLDDILPVPKTDRPYEDRPENCTFDDNHMCRWVNDQDDMFDWILWKKGTPSRLTGPSSDHGGKGMYIYTEATAPRQPGDKAQISLIRSSGISCMRFCYHMYGEDTGELNLYHYNTRTRRRRLIWSRSGPQGNEWLESKITFLAGTYQLTFEAVRGSGFKSDIALDDIIFTDGPCVSKPSQRRTTMDTTTSSIDDSLQVSLLMELNGTLYIILWLVHQKRDIGCTCALFKEVLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4A2</accession>
    <name>A0A6P8I4A2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Afadin- and alpha-actinin-binding protein B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298948</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563394.1">
        <property type="nucleotide sequence ID" value="XM_031707534.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4A2">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="GeneID" id="116298948"/>
    <dbReference type="KEGG" id="aten:116298948"/>
    <dbReference type="InParanoid" id="A0A6P8I4A2"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF4">
        <property type="entry name" value="SSX FAMILY MEMBER 2 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="128"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563394.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="70237" checksum="4F5CD85922837379" modified="2020-12-02" version="1">MNFDEHGNTDFLTRYTSHSSRHSSPDKSSDQDGLQFGSPLFAMLNNSSEKQFCRRDNVDQCLAYLNQEFCILGFNPLFTPSRNGKELSDTFDIVRLINCTYELLQLQQQNSKVRTSLEERNLRSECDNEFLIQNQNRLKAQVESLEREVAMSNERERQLKSKITKTKEQLKNEKDEVKRLKSNFQQFHNQISHENKKKEKEVVRLKERVHQMLTDKSQEKRIGMEILNSIQRADGKRAMWNTGNRSEEEMYRLLVTNYEARQKELIKENNDLRDSLLDMQAELIGALNQKSTGYDSDSEGCTSDDECSGLSVRSLPAGHFNMPYELVREGIEKSLREKWRVLKSRLEQANKGSSSSSPQDNEEKAAXTEEVEKLKKQLDNYXHIVEQQEALIESFQVKESEGNAQADSSFLSDSRMCEEWERLKQEKVMFNEQKRTFEDERRNFTESAAKLXYERKKFEDERSNFIKQQLLITPQRKLPSVYKKLRSPDGQNSPPRLQYSTPMFSPAPRENREKKSIHVPREGPVETPSTQDLYLALSLQADDNEDSNNETPKHPSKANTSPPPSRCSSDSIDGTNASKSRSRRINEHAQLVKRALQLRQGSPTCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5J6</accession>
    <name>A0A6P8I5J6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116299334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031563834.1">
        <property type="nucleotide sequence ID" value="XM_031707974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299334"/>
    <dbReference type="KEGG" id="aten:116299334"/>
    <dbReference type="InParanoid" id="A0A6P8I5J6"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0455">Luminescence</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="74"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="11">
        <location>
            <begin position="489"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="573"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="643"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031563834.1"/>
        </source>
    </evidence>
    <sequence length="1128" mass="124132" checksum="D189089CDB230D0D" modified="2020-12-02" version="1">MLSXIPRHLVKSSTHLRQSLTHKSSTILASQAINSRVKCLHTTAPTNTRIVRSSSHHPDISIPTNKSYVEFILEHCEKHGDKDAIADAXTGKSFTYKDVXDLVKKCGSAFKRMGKNQKDVVAIYMPNLPEYPMVFYGIQAAGGIVTTVNPTYTVDELAYQLQDTSTKYLVTTPDFMVKAREAASKVKLPSDNVLDIDTLWNLVLSDDGSYLPKVHTTNTPSEDIVSLPYSSGTTGHPKGVMLTDTNYISHALITGTEKFMFRRSDLPQLLVMALLPFFHAYGLAFIMGVHFYLGSKLFTMPQFDPEAFLKAIEDHRITELPIVPPIALFLAKHPMVDKYDLSSLESILCAAAPLSKEVEQILKKKFPNVNIIRQGYGLTETTAACILNPNDKVKSGSIGVLLPNQEXIVKDLETGEHLGPGQDGEICVRGPTITKGYLNKADQTEVTIDKDGWLRTGDIGHYDEDEYFYIVDRLKELIKYKAYQVAPAELEAVLLTNPYITDAAVIGIPDEEAGELPRAFVVXKGGITAXEVQQYVADKVAPHKKLRGGVEFVESIPKSASGKILRRQLKDRYRSADALTGKSFTYKDVSDLVKKCGSAFKRMGKNHKDVVALYMPNLPEYPMVFYGIQAAGGIVTTADALTGKSFTYKDVIDLVKKCGSAFKRMGKNQKDVVALYMPNLPEYPMVFYGIQAAGGIVTTVNPTYTVDELAYHLQDSGTKYLVTTSDFMAKAREAAAKVKLPSDNVLDIDTLWNLVLSDDGSYLPKLPTTESPSDEVICLPYSSGTTGVAKGVMLTNFNLISHALILGNXKFMPCAPDMPRALVMALLPFYHVYGLAVTLGMHFFIGSKVFCMQKFDPELFLKTIEDQQITELPIVPPIALFLAKHPMVEKYDLSSVNLVTVAAAPLSKEIEELLSKRLPNVRVIRQGFGMTETTAACILNPSDPSLVKTGSVGLLLPNQEVMVKDLETGKPLGPGEPGEICVRGPTITKGYLNKPDQTALTIDKDGWLHTGDIGYYDEDEYFYIVDRLKELIKYKGFQVPPAELEAVLISHPLITDAAVIGIPDEEAGEVPRAFVVTKGGITAEEVDQYVADKVAPHKXLRGGVVFLESIPKAASGKILRRELRDNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6F8</accession>
    <name>A0A6P8I6F8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Uncharacterized protein LOC116299055</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC116299055</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563547.1">
        <property type="nucleotide sequence ID" value="XM_031707687.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563548.1">
        <property type="nucleotide sequence ID" value="XM_031707688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6F8"/>
    <dbReference type="GeneID" id="116299055"/>
    <dbReference type="KEGG" id="aten:116299055"/>
    <dbReference type="OrthoDB" id="5975586at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000350">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653139" evidence="9">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031563548.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52670" checksum="1DA976EB08DE304A" modified="2020-12-02" version="1">MKAIILIILPTLSLLPMISYAGDKSTKHLTELNCPESKTALFYWLPYENQINFDNRTKQVKGTLKDYITQALQICCSSLKLNYSQMKVDSSKEIELFIRKDRSAGLSFYFPVFANKYQKEKFQRPFVGLYDSPGPVIFVYDKDNTKGAVFTALTQSWQIPALCVLLASISGVILWFLDHKHNKHELPQEFHRGSCVGLWWAFVTMTTVGYGDIAPKSFRGRLFAVIWMIIGCIALTLFNAQLTAMITSNELPNEMNLIGKQIVIPRGGKPFLEEELNLGAEYREEDFSDLLTKIRKKTDDIMMTYNYWEIKMAQTYGEQATGTKTRIKVIKTIDHRFTIGITASGNITNTGNFLKCFEREIVDSIIVKKEEIYGALLGGNSKITKPTEPSIKSNLPYSFETMATLTALAVLILLVILGLVLEFCGKQESRLRGNREELLSSPNSSADDQRWYRNRSNWQSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6Q0</accession>
    <name>A0A6P8I6Q0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116299666</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564229.1">
        <property type="nucleotide sequence ID" value="XM_031708369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6Q0"/>
    <dbReference type="FunCoup" id="A0A6P8I6Q0">
        <property type="interactions" value="2292"/>
    </dbReference>
    <dbReference type="GeneID" id="116299666"/>
    <dbReference type="KEGG" id="aten:116299666"/>
    <dbReference type="InParanoid" id="A0A6P8I6Q0"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="430"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031564229.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="53334" checksum="66AA0B6BEB8FFF7D" modified="2020-12-02" version="1">MADVDDQQENGDLDLWSSILRDVQSSASRKLRAHKSILLLGNDESGKSTLISKIRGKEDEISRGHGLEYTYLDVHDEELDDYTRLNVWILDGDPRNKTLLKYALTPKNVNDTLVALVVDCSKPWSIMDSLHSWTEILREHIHSLKLTPKQLNEMEERIVQQFQEYVDPEEVTEENKRRSGTGIKDEEKVLLPLEENVLVDNLGLPMVVVLTKTDSMSMLEKENDYREEHFDFIQQHIRRYCLKYGAALFYTSVKEEKNCNLFWKYIQHRIYGLPFNSSALVVDKDSIFIPSGWDSMKKISIINEHLKVIQPDDGFDDHIVKPIQRKPLQEKEIAAEEEQAFLAKQQQLLQKNPPSVSSIGRQQPDITKPRSPGSPSTRMSDRRQSGGVSTPAAGRAKVDNIKVPAGAGAATSEGVLANFFNSLLNKKTAAAAGTPQGRGVPSVRSDAAAELDRMTRSKKVVGQPGRNEENSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6U1</accession>
    <name>A0A6P8I6U1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gelsolin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031563688.1">
        <property type="nucleotide sequence ID" value="XM_031707828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6U1"/>
    <dbReference type="GeneID" id="116299201"/>
    <dbReference type="KEGG" id="aten:116299201"/>
    <dbReference type="InParanoid" id="A0A6P8I6U1"/>
    <dbReference type="OrthoDB" id="10389858at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF137">
        <property type="entry name" value="VILLIN-LIKE PROTEIN QUAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="86"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="201"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563688.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="47341" checksum="269A68B4E1FB5829" modified="2020-12-02" version="1">MSLESNGVERTDYPWKKCVVEYSSMTIDEEEYRKTAKSDPLWANVKSIKEKHPMIWEVYNSQVTELVKEEEKVWESEETKKKPYCRFYNDRAYIVLCWHKAAITFIHDLHIWVSKHCSSQDYKLATIKAEQLNLFLDEKPILHREIQLEESDTFHTYFKVEVRRKPKDKSEAKTKYDKCCLLQFHEEEAGLKGKKKQWMVERKFLQGNLCSDDVFVIMNEYFMYLWEGKKSIKEEKDAAEEYIRQKERASTLRFKSVVRDSFEDKDHPAYHLFPTKGKTYKATPDNTPKNPIKRLYYLTNNNGKLLNRAIEDTRTICKSNLTSNCIYLLDTESQLYVWIGSEVSYQERCRALFVAENFLMEEYPKDVDGKFHQPINKPITLVNEENPYLFFDRALMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7E1</accession>
    <name>A0A6P8I7E1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transcription initiation factor TFIID 18 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116296687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TBP, and more strongly with TAF10 and TAF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560605.1">
        <property type="nucleotide sequence ID" value="XM_031704745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7E1"/>
    <dbReference type="FunCoup" id="A0A6P8I7E1">
        <property type="interactions" value="1682"/>
    </dbReference>
    <dbReference type="GeneID" id="116296687"/>
    <dbReference type="KEGG" id="aten:116296687"/>
    <dbReference type="InParanoid" id="A0A6P8I7E1"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000028">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031560605.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14201" checksum="98A8B4A678133D5D" modified="2020-12-02" version="1">MEDNTNEEEVSENEPVETPDAGKRKRLFHKELRCMMFGFGDDQCPYTESVDFLEDLVVEYITEMTLKAMEVGKKGKVHCEDIVFLIRKDPKKYARVKDLLTMNEELKKARKAFDAESYGEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7X6</accession>
    <name>A0A6P8I7X6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116297145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116297145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561167.1">
        <property type="nucleotide sequence ID" value="XM_031705307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297145"/>
    <dbReference type="KEGG" id="aten:116297145"/>
    <dbReference type="InParanoid" id="A0A6P8I7X6"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction endonuclease type IV Mrr" evidence="3">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031561167.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31462" checksum="165B170A43DB7629" modified="2020-12-02" version="1">MKILTVLTCWSARCPPIRGISRKAVGRTFELLTVNALQKYSFEVLLCGGSRDRGIDFRGAWKLNSRTINVLGQCKCYKRRLGPVHVRELEGAISHEHEATLTLLVTNTGFTKDAYEHFMSSTYPLALTVLDTTILHQCDEETLXQTQALDTTHFHKNSLSLNNLDDKNANVCSQEKPKNDCIKITQTDQYMKQSLQVERVYKELISSPQDHHYNVDLSQSSYNNHDCDRLPLHRGNISLFELNITARQLLPEIVIGRSLKKSCHPMLLLHEDSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7Z0</accession>
    <name>A0A6P8I7Z0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner centromere protein B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564679.1">
        <property type="nucleotide sequence ID" value="XM_031708819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7Z0"/>
    <dbReference type="GeneID" id="116300056"/>
    <dbReference type="KEGG" id="aten:116300056"/>
    <dbReference type="InParanoid" id="A0A6P8I7Z0"/>
    <dbReference type="OrthoDB" id="5990183at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564679.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="65758" checksum="CAE2E10F2467C463" modified="2020-12-02" version="1">MNTKITHNETCKVLEQGVEAVSEATMSSSSPHQRQANRHRKINNEAISNERVVEKNKQNKQSDAKEDINSDDNENHQRTSTKYEETLDSNEGSEYVILSEQQEEAKTISDMPVNGLITPPALDTSQLDTDRLSNSPITTSPTRGSQAGHLLAKRRGNEQNIYNASTTVPGISTGNESSEDNELELKTRLPSLGPQTSLTGHPLDGSEKVFQVQHRPGRKLVIRSFSAPNSPDMSPVASPRISPTSEVSTVLAEMITDTRSAPNSPLARRSIKKTFRAVGMTARFAVGAYANPPNSPVSRARVSREPIVLATPSVGNAGIKFDRYRRGSLAVGNEAFKVPVQRGKSRSVCEVTLNESLHNHLLTKAMETEERMELPWNAWIAAKRRESVSQQPTTTLAPMPENKQLQVPASPNARRRSFQQWLNEKDMEQLRQMHEQSQIEERNDAERTGRQVKGKSFEEWLEEKHRESQREKEKLKEKEEAEKSEVEKKMRRRRMSQQKYQSWLQEKELKALEEEEKLLGEAKKKLEKMKVKWEEEDEMKKKAPVAMGKVAVGRTKSCPTSNTEDGRKISRQRFSSLQVTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9J9</accession>
    <name>A0A6P8I9J9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase mib1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116300081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564703.1">
        <property type="nucleotide sequence ID" value="XM_031708843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300081"/>
    <dbReference type="KEGG" id="aten:116300081"/>
    <dbReference type="InParanoid" id="A0A6P8I9J9"/>
    <dbReference type="OrthoDB" id="5990192at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031564703.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41701" checksum="193A42B8A7D67B6C" modified="2020-12-02" version="1">MASGFARKLCGRKQDEEPQEVVVPLRFXEEXRAQXXARLQPETRVQREQKDDLFDSIKRCDLEHIKTLKTKFSFKNIKDNHKRTPLHVLADSKPEQKGKDGVLKEIFMVLKEAGCDVNCVDQYGNTPVKLAAEKGCIPVLKCLLEEKADVTLPDXHKGDTPIHWSAKNGKYEATNLLITHQRDFINPQNKDKQTPLHLAVQNEHTKIVYLLLFRGADRNLKDKNDFTPLRIAERANNEEIVDLLRKSLEELYEMQTKVGQGEHVEPDSGVCAXVSIPWTRLQAANVTYNINVGEGAVAXIGPNSSVNLSHEQNLSQHATLTSPSHLGPGQQLVSPTSSPLTAGSPTGFSPTAAIQQPLHHASSSSSAGSPTASSPATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA44</accession>
    <name>A0A6P8IA44_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neuroligin-4, Y-linked-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116297482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561565.1">
        <property type="nucleotide sequence ID" value="XM_031705705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IA44"/>
    <dbReference type="GeneID" id="116297482"/>
    <dbReference type="KEGG" id="aten:116297482"/>
    <dbReference type="InParanoid" id="A0A6P8IA44"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027684851" evidence="4">
        <location>
            <begin position="26"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="32"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031561565.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67379" checksum="D8B28EA23FC67B85" modified="2020-12-02" version="1">MDFVMKSYSLVFICICITLEKHCQGESESSAVIVSTKYGLLKGQTRYFPQPVGNISVVNKFLGVPYAAPPIGELRFLPPQKPKHWKGVYDATRFKPVCYQDPSYNQMFWKKDVNWSQSDDCLYLNVYAPNTTLSHERYPVMVYIHGGGYETGSPVVSPGDALPMWEVVLVTIQYRLGPFGFISTGDSAAPGNYGMLDQIEALKWIQLTIEAFKGDPSRVTIFGESAGGSSVGLLLLSPLSAGLFHRAIALSGSDFAPFAVNTRKEATDLGRATAKKFDCPKETSKDMITCMRNVPAWIIYNKTKGDVNSWRPVVDGIFLQDSPTNLRKANKFHPYPLMVGVTSDDGSFFFNENEVYKTDSLENFNKSCLGLFKSIRRFGWEDRIILDDHIEDAVLFQYTPWSDTKSKHTLRQGLIDLVTDFAFAAPAHAILELHAKVAPAYHFVFSHQSKLRNNLPSWKGATHKDDTPYEFGFPFMNLTVLQHYDEHDKNVSAIMISLFTNFARTGNPTPQPVAGCTWTPFNENNNPYLNITAKPEMRNNFHIRNIAFWNKYYPKLLTTCKYPEISVSKSGGLSKFFMDPYTIVVIAIVLVCSLMVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAE2</accession>
    <name>A0A6P8IAE2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM92A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565093.1">
        <property type="nucleotide sequence ID" value="XM_031709233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAE2"/>
    <dbReference type="GeneID" id="116300373"/>
    <dbReference type="KEGG" id="aten:116300373"/>
    <dbReference type="InParanoid" id="A0A6P8IAE2"/>
    <dbReference type="OrthoDB" id="60621at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF2">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06730">
        <property type="entry name" value="FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565093.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31657" checksum="C510C5A5647AA3A2" modified="2020-12-02" version="1">MKNASSSSASESRMEARARDHELKIVSDRIALAEKHFTSLSKDVLSYNASLEGVKEKGNKLSSSLDSYADMEYPSVRNAMQNVSECVATMQDYLTAEVNFLHGKVAQPLSFYATNCKIAKDYAKGAITARDKELAKLKSLDKMKSKDPNNKSKLAKLEQELQKASIDSGRARQTMVDQMVIFEKKKIEDLKSIFGSFFHGQLLFHAKALETYTQAYKHLMAIDEQLDLEAFENDIHPATIPTRLDSIKSGSQSSLHYDSQGSLRGSQLSLNRTSQSMHSQGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBV8</accession>
    <name>A0A6P8IBV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc transporter ZIP9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564881.1">
        <property type="nucleotide sequence ID" value="XM_031709021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBV8"/>
    <dbReference type="FunCoup" id="A0A6P8IBV8">
        <property type="interactions" value="2485"/>
    </dbReference>
    <dbReference type="GeneID" id="116300206"/>
    <dbReference type="KEGG" id="aten:116300206"/>
    <dbReference type="InParanoid" id="A0A6P8IBV8"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031564881.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="33312" checksum="9CA086FEB63BB416" modified="2020-12-02" version="1">MEDAMRLFSLCACMLVGSYVAGAIPLAFSLSEKRLRMVSVLGAGLLVGTALAVIIPEGVHTLYGQEHVHGHAGHTHRHLHEARSANKESHAKATHSDVHPLTEHIHKVEPDVFIGLSLCFGFIFMLLIDHISGGHSHGSSDVEGNNRQKHGKLTTTIGLVVHAAADGIALGAAASTSKADVELIIFLAIMLHKAPAAFGLTTFLLLEGMERNRIRRHLVVFAAAAPIMAFVTFFGLGQHGKEMFTSVNGTGIAMLFSAGTFLYVATVHVLPEVGGHIDSNEQSKTNLNNKADLILMVVGICAPLLLSQTHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC89</accession>
    <name>A0A6P8IC89_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NCBP3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563282.1">
        <property type="nucleotide sequence ID" value="XM_031707422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC89"/>
    <dbReference type="GeneID" id="116298851"/>
    <dbReference type="KEGG" id="aten:116298851"/>
    <dbReference type="InParanoid" id="A0A6P8IC89"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563282.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="44088" checksum="869C06DB71EF538E" modified="2020-12-02" version="1">MEFEELKIEIPIEEEQEEEQEGLQLPPKKYENTAGGFVTGFDVNSKEAIERKARRRKRFGVIEEKEEEETNKDKETDGNDENEMILPKDTPKIPEGEIRKDALHVYGIDNMSTKDVFNYFEEYGPESIEWIDDASCNVVWEDEHSAARALDSMGKSLNSSEPGNENSVLQWKAGPLCKKAKGRLLLRFATKKDKKQPGAAKRSMYYLVHGYPGQSTGKKKGIVSKSRKRKLMQDKERARHKYSGEPDVEFIEKMEVEEQEKMEVDEPAMKVIVKNDRTLESTSKEVPERLRMRMHADDLGSENDPDEKSKIHDRLQERLQERKPDKLQDKIQDRIQIEVDNTAKNEGIDLRERLKTRRKHGFDFMDRPSLSIEIREEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID60</accession>
    <name>A0A6P8ID60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116299442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563962.1">
        <property type="nucleotide sequence ID" value="XM_031708102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299442"/>
    <dbReference type="KEGG" id="aten:116299442"/>
    <dbReference type="InParanoid" id="A0A6P8ID60"/>
    <dbReference type="OrthoDB" id="408971at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563962.1"/>
        </source>
    </evidence>
    <sequence length="1021" mass="119695" checksum="007527B4C622232E" modified="2020-12-02" version="1">MDEPVPEIDIPILKPVKTTNISNKNMIETVAYSVQKQLNEFADWIISYVPPDVKKTVNERVEALKKTVNDIYNEKEKLVAEQKEMNIAYKKESAMKGFLSSYRIKGEEKIGPKSFIEKYKAIVIRTVKKQQKPIKMKLVLECVFYKKEKKEIVYTFGYFHSNIVIIVQATNIEDVYEKLTGDILEKISNFQNSGSGWIFNKVENLDIHIDKYKPITAKSYIPLPGKLKSKEAIINPKNKDNQCFKWSVTRALFPEKRDNERITKALRNNSEKLCWDDIEFPVQLDKITKFESNNPGYRVNVYRYINESVPIGISEVENEDSKKTINLLLISNEEANHYCWIKNMSRLISSQITKNGHCRYYCERCLNSFKTKKALGIHYEYCKNHEAVKITLPKKGSTISFNNYKHSMRVPFTIYADFECFTESIDTCQQNDERSYTQRYQKHKPSGYCYMVKCYDDSIYKPKLYRYTAKSEDEDISQRFVESVEKAVKNIYKKYHYNKKVNMTDKDNMNYDKATRCHICDEELNGDKVLDHDHLTGKYRGAAHNECNLNYKMPKHIPVIFHNLAGYDAHLFIKNLGSTDGKIDCIPNNEEKYISFKKEIIVDTFEDKNGKVCNVKREIRFIDSLKFMASSLDVLVSNITDCGKCKTCSCVRNNKKCGECRSCLFGSKNCENPSDMMTSNLRKFYGGKKLRLLLRKGVYPYDYVNSLDKLNETYLPPKSEFYSKLNSRDISDDDYEHAKEIWKTFKIRSMKEYHDLYLKSDVILLADVFETFRDVCMENYKLDPCWYYTAPGLSWDAMLKKTKINLELLSDSEMLLMIESGIRGGISMISKRYAKANNKYMKSFNNKEXSXFIKYLDANNLYGWAMSQKLPTHGFKWMNKLELKNWKKHPCILEVDLEYPVELHNLHNEYPLAPERLMINRVEKLIPNLADKTKYVVHHETLKLYESLGLKITNIHRGVTFHESEWLKQYISLNTELRTKAKNDFEKNFFKLMNNSVFGKTMENIRNRQDIRLVTNEKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDI2</accession>
    <name>A0A6P8IDI2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyadenylate-binding protein-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116299723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564302.1">
        <property type="nucleotide sequence ID" value="XM_031708442.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IDI2">
        <property type="interactions" value="2156"/>
    </dbReference>
    <dbReference type="GeneID" id="116299723"/>
    <dbReference type="KEGG" id="aten:116299723"/>
    <dbReference type="InParanoid" id="A0A6P8IDI2"/>
    <dbReference type="OrthoDB" id="5971158at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="85"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564302.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47754" checksum="A67FBC8836A82F42" modified="2020-12-02" version="1">MSNNHSGRGVASKEYKEPLRRPGQSRQPPQNLPQDGVPLNSNATGNLKPVTATSLNVNAKEFVPRFIVPTKPQEPSVQLPDQQVVDYVKESLDRLTYSPGEFDLVVDDLALAWKARIHDVSTLNEVARVIVEQSIVQTNFTYTGARLCDLIARRRDLTDIQDGSKTFRTIFLTRCSEEHNKREDLLKNPTTVARVHGFAMFLAELFSTFRFEGSPQPVQILEKKLLEMLITLINHRTDDSLLYAGRILKLTGSLLEEPQFVKKDSSDKLTEIFNEINTIVQPASPHGRXIKVFLSSVIALREKNWGRETTPVPVANSTSSTLSADAAPFQFPYSSTLDPTQNADEEDVYYPPDDLLDYYEDITPVYNPDQWNEYCEDNSEPDDNYYQNDNGENGDEDEAFTEEMRQDFDKFMLEQNHPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDK7</accession>
    <name>A0A6P8IDK7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase NRDP1</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING finger protein 41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase NRDP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299794</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031564362.1">
        <property type="nucleotide sequence ID" value="XM_031708502.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IDK7">
        <property type="interactions" value="1758"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299794"/>
    <dbReference type="InParanoid" id="A0A6P8IDK7"/>
    <dbReference type="OrthoDB" id="6017243at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16634">
        <property type="entry name" value="mRING-HC-C3HC3D_Nrdp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015036">
        <property type="entry name" value="NRDP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037255">
        <property type="entry name" value="NRDP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08941">
        <property type="entry name" value="USP8_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160088">
        <property type="entry name" value="NRDP1 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="16">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031564362.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36704" checksum="9FEF3215813D2FA3" modified="2020-12-02" version="1">MGYDVGRFQGEVDEELMCSICGGVLEDPLQAPACEHAFCASCIHEWLNHQQSCPIDRRNLTPLQLKQVPRILKNLLSKLLITCDNSSFGCEAIVRLDGLYSHLSNCQXNPKRPVQCEKGCGLVVPFDELVQHNCVRELNVIIQNQNLKIVELQSQIDDQRQQLNEQKRELRVLKDMMRAMRVINMPQALPALPNNQRPSVSHDSDELREWVSSLEQARVTRWGGMISTPDAVLQAVIRRALSDSGCPSNIINELMENAHERRWPPGLSTLETRQLNRRRYEQYVCRRIAGKQAVVIMSXENEHMGEALTLDPGIIMIFAHGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDV4</accession>
    <name>A0A6P8IDV4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116300020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031564637.1">
        <property type="nucleotide sequence ID" value="XM_031708777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300020"/>
    <dbReference type="KEGG" id="aten:116300020"/>
    <dbReference type="InParanoid" id="A0A6P8IDV4"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="1175"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1386"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="870"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="968"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="968"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564637.1"/>
        </source>
    </evidence>
    <sequence length="1936" mass="217753" checksum="D4879718236FD9EB" modified="2020-12-02" version="1">MDEQKIPTSSHESGELVLENENKVLKPPPRRKKSLRKNKMDADNARRITASHSAKAENEQSQTSLDDKMVKEEPFSVNVNNNNRNPANLGNNLDEVGNQCLQIPARQPSNGSKTESKISKSPTQNKSNNECKESKAGETPEYFSGCTIATKEDEVSKMQKRNMKDNINEDEADAGQDIEMGNRNGSLKPKAKNTETHNTGKARVIHDGNNGIKDPSSSDQTTNKAVVVSENFESFCLVENVANPGENGAQNATTVDQDPKEIFLRRKEDYSKSCSDSEARTSGIPAQTSEKLTNPNIDNLNSQNNRCVNTLSCDVHKDSLHDPRILHQADSNFSGADMKDTMHQLQRNDNNMLSNDPEQKLKNLETNQMNDQNNTILNFQNPLCREYNPIIKADNEKVLRQKCTAFSDNEVLNPDSLSLSMDLRKESNGKSQDTEKIEDGKVIIPYQNLEDNNQDNTCEGDLGDDEEVFSSDTDSDTYYSDFTSSEGEYNMEDAEKLWYIDDGEKEGNYPVSKEVEPESIKQILSAFQDTETVTVTDDTDGDSHHXDGSHGDGGHGNEASTGLELSEDRAQSLKRKIGSFKVVKVLAPAVDMVNVKEASVGMATDLVAMGTKPALDTTKTAEMAILALHKEHKQKQATRKEREREKRKIREVIIREKTREKLEISRPRSIVGEPRTRSRSTGDLEQAGKPKPLLKKRHSIPVRARSLKLRQVSELDFDERAESALFDGHNTYPPGVLKGGLVSSLRHLEESRERRDSGTPLIKQPSIKRENVSKLVAEVEPQGGRTAESEELILEQPSISLQKVENIESESPGQAGETTPLYLLEQRPNAVDNLTAVIQVDRLSEEEAPNLRRTLSTVREENSSLLENASSFSISSRGSSISQDKESLAEEASSVAVGSDTSSNSNLETIDSENTPDDTVKKVKKWELKNENWGDENSLASSEGIAMTTPISTQDDISKQDHLLSQSAPTTLTSISKTPLSDGHNKESYTSLDSVQRRQMNITRAKRKWLSQSAVVTSGLPQSPTEVKLTSFRKNGELDLPDSGASDHPRSKSPGEEKSHIKENAKQVNFGVAHDVTRGDATPKRPPRKGKLSSSASFASPRTTRETKKKPRRDNVKERREGGSRWQTLSGAIDSDWLARLSSANKLPTEQMSDEIITLVTDALPASFPAFPTDKRAQIALELYTTERTYVRGLEIVIELFKNQLEEYLEPKEKVTMFSNIDEIFKVNKDILFSLCEKVNHWKDTQVIGDVFVDNGDRFKIYATYCNNYDAAENLIKQKIKKKKEFDDFLEACYKNVVCQPGLKLPAYLITVVQRIPRYLLLLRDLIKCTPANHPDARPIKEGLRKMNNIAEYINNQLQAVQGQRAMTELRSRVIGIKAFETAGKSLIKEGEVYIMSTKRTYKCLLFNDMVVFAAKNVNKRSEVELTLELESVWVADLEDNDPQTSKEDAIELYTPERSYTMYTGTRNEKKHWLQKLRTAIAIRLHGEMATDSSEIEHRKSAFTYKDGRIYCGTFVDAKRHGHGVVAWQNRTRYVGNFEDDERNGIGELTYSTGEKYNGEWLDDKQHGVGTLTYPNNDIYTGEWQRGKMNGKGLINFSNEDVLDGEFVDNEVCGIARLNCVNGLTYEGTWKNSKKHGKGRLIKPNGDTYEGDFSNDRMMGFGTMTYASNKATYEGQWENNQRHGTGVYTAPDGTRYEGEWRCDHMSGRGKMLYPNGERYEGSWYRDMRFGKGILRCQEGVYEGKFEYNVRHGIGSLRYSDNSEYEGEWQHDQRHGQGKMIYADSSVYEGNWMLGLRNGRGKMTFSNGATYEGNWDLGSEHGPDGVFIDAANSYSYEGGWEYGCKQGQGVERTSTGTYEGDFKANMRHGKGVETLLGGIVYEGHWRDNRKVGEVIRRKRWGETETTTEIQYWKEGQLLNKDETIAPDLPFIQRITNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHM9</accession>
    <name>A0A6P8IHM9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Neuronal acetylcholine receptor subunit alpha-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116301384</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566301.1">
        <property type="nucleotide sequence ID" value="XM_031710441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHM9"/>
    <dbReference type="FunCoup" id="A0A6P8IHM9">
        <property type="interactions" value="739"/>
    </dbReference>
    <dbReference type="GeneID" id="116301384"/>
    <dbReference type="KEGG" id="aten:116301384"/>
    <dbReference type="InParanoid" id="A0A6P8IHM9"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028518189" evidence="14">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="30"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="244"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031566301.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="54053" checksum="F54FD5B67E695AD2" modified="2020-12-02" version="1">MLGIFVAVYTFVGLLGVHEADAVRHNDHEHKLIKDLFTNYSSEVRPVIEHSDPVDVRFDLAFSQLVQLDAKSQILTSKIWIRQHWSNPYLTWNASEYGGITFINITPKLVWKPDIVLYNSIQGDSGEMYNFQTKVSLFNDGSFQWFAPTEVKSICKIDITYFPFDTQTCTMVFGSWTYASSFLNLSLKRDTADLSGYTVSGEWDLLSATAKRNVVKYSCCPDPYIDITYTFEIRRKVLFYINNLIFPIIALAVLGMFGYFLPPESGERISLLITIMLGLSVYTLIFTENIPATSEVTPLLSRYSTAIMVELGVSLILSCLIVGVYHGDSTSKHMPRWFEFLVFKILAKLFRHSNPMKKESGREGSQRGNGMVSADRTSLYFALNKRASQDHGGAEQRLAPNERQSCASLNKKLDEVITKLDDILENNNGSQDDDVRPKKWHFAARVLDNVVFWIYTITVIISTIVLSLFIPYDITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ45</accession>
    <name>A0A6P8IJ45_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein ZIC 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566503.1">
        <property type="nucleotide sequence ID" value="XM_031710643.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IJ45">
        <property type="interactions" value="1825"/>
    </dbReference>
    <dbReference type="GeneID" id="116301563"/>
    <dbReference type="KEGG" id="aten:116301563"/>
    <dbReference type="InParanoid" id="A0A6P8IJ45"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002540">
        <property type="entry name" value="Zinc finger protein Nv-ZicE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000035">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000039">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000041">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041643">
        <property type="entry name" value="Znf_ZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18366">
        <property type="entry name" value="zf_ZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566503.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45159" checksum="EF3C4C29771B2DEF" modified="2020-12-02" version="1">MTSQDLYSNSSSAHFPYSSGQNTRSSRPSSHEFIFAGQENFTSGPPTTVRSPNTAMGLTDTGMPRGASIPRQHNMIHGSVVHPLHPNHYSSLHDSHRDGGNGSPHGFFSVAHAHDPPGHYPQNGGSLGQAYRFSFPRDDKPELAQYASPFVPPRYEYMPHPGLSMPPSYLRQPLSHVVTCEWIEPGSKGKPCGRQFFRMHDIVAHLAEDHVGGPESSSHVCFWKECARNGLPFKAKYKLINHIRVHTGEKPFPCPFXGCGKLFARSENLKIHKRTHTGEKPFICEFPGCDRRFANSSDRKKHSHVHTSDKPYICKVDGCNKSYTHPSSLRKHMKLHAKPSESGMESPQDEISQNGKSNSSPFPSASTYPPMSEWFNRIPGAPTHHEHFHMDNPTTLGPSQAALASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJM2</accession>
    <name>A0A6P8IJM2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116301900</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RBR family. RNF144 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031566930.1">
        <property type="nucleotide sequence ID" value="XM_031711070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJM2"/>
    <dbReference type="FunCoup" id="A0A6P8IJM2">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="GeneID" id="116301900"/>
    <dbReference type="KEGG" id="aten:116301900"/>
    <dbReference type="InParanoid" id="A0A6P8IJM2"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20342">
        <property type="entry name" value="BRcat_RBR_RNF217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20350">
        <property type="entry name" value="Rcat_RBR_RNF217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000051">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047551">
        <property type="entry name" value="BRcat_RBR_RNF217"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047552">
        <property type="entry name" value="Rcat_RBR_RNF217"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031566930.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36195" checksum="B5BFC8BCE5F76825" modified="2020-12-02" version="1">MSFMSIESIPPNSESFLLESYVPCFVCYHHGGSSNAVKMRSCCTGFLCTDCLRCHIETKISQAIVKITCPLEECDTFIPEEEIQQLASEELFEKYKKFQIDMEQNPNVKSCPNCSKIFTFRPKEKSEIELDTQNKNALGKKKLSDDSKVICTDCHLVWCFECQAPWHYGISCKDFCKGDKSLKIWAKNKGNYSRNATRCPKCQIFIQKSAGCDHMVCTRCNTEFCYRCGSRFRSLHFLGDHHDPLSVFGCKYNYKPHHPAQRVIVRGAVLSGKLLALPVMAGLVASAGCLVLGAGVVVIPGYVSYRMIKKKKQKRKSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJP6</accession>
    <name>A0A6P8IJP6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Pyroglutamylated RF-amide peptide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC116301937</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566966.1">
        <property type="nucleotide sequence ID" value="XM_031711106.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566967.1">
        <property type="nucleotide sequence ID" value="XM_031711107.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566968.1">
        <property type="nucleotide sequence ID" value="XM_031711108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301937"/>
    <dbReference type="KEGG" id="aten:116301937"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="293"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566966.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566967.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566968.1"/>
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    <sequence length="356" mass="40827" checksum="3E2E9BC2B55485C6" modified="2020-12-02" version="1">MTNFTNNSSAFITTTPVIISQYTLYSFIVVFGLIGNVLVFKTICSHKRRRINEYFILNLVITDLGTCSLSIPLDVTEQVTKRFLFGSFLCRIIYPLQTIFLSTSVLTLLCLSLERYKAIVLPLQPKLRCKTVKRLMVGSWVLSILLVIPYIKVLEYKDEQCQENWPNNPVFVQAYTSGVFLTLYFVPLLIISMCYSRVLLRLYMDKSQVVRLMGGKRPYLDKMIRRRAEQNLRMVRLCVTAVVAFALCLLPFHVLWLWHDFGNGGKDPNFSTMLTFSNIVVYSNSVINPLIFGKLNLRQCCSKNVNGKTLFSLXSHTTGSFELSSLRSRSRSNVDEQVRGIFKPRNSLPDELVKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKF7</accession>
    <name>A0A6P8IKF7_ACTTE</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116302187</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC116302187</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567274.1">
        <property type="nucleotide sequence ID" value="XM_031711414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302187"/>
    <dbReference type="KEGG" id="aten:116302187"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
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        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
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        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TauD/TfdA-like"/>
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        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="TauD"/>
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        <property type="entry name" value="Clavaminate synthase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567274.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44986" checksum="856C06934D50849A" modified="2020-12-02" version="1">MAIRLLLKKSFKPAELISTXSALYLFSRTLASEVPSYNFECSFKPLSPEEISPKSDYEIAGRKWLPGSMGKGFPKYLNKPKEGFPYALEVTPGQNYNLGEWAYIVRRLIDDNLSKYGTMLLRGLPLEDSKEISNFSTALGYKAMSYPRGGGADRSLQDADAQVYTASEEPPEFTIELHNELGYLPTYPRKLIFYCLQEPAEGCGGFTVICDSKEFVNRLDPKLIKKLDEKQIRYYHSLPDESKSTYVSWQQAFKTKDIEEVKAYLEKGGYGYSFDEKKGIVTFWNTLPAFMPHPDTGEKIWFNSVHITHHTGLKESPMYPGEDKLDTVYSWDSTYGDGSPIKLDVIQHIRACMWHSTYGFQWKTGDMLVVDNMSALHGRLSFTGKRKILAFLMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKT5</accession>
    <name>A0A6P8IKT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein ZK1073.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567576.1">
        <property type="nucleotide sequence ID" value="XM_031711716.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="NDRG"/>
    </dbReference>
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        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567576.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37620" checksum="45D1B8C5C87688A0" modified="2020-12-02" version="1">MSEASPPSERVEKVGDLTVYIVGEEQKSEDKENVKKKEVMVTFHDIGMNHKTCFEKFLNHEDIKSIHDRFVIYHIDAPGQETGAEDLSNDYQYPSLKGLSDMVGNVIDHFALKDIVCFGDGAGANILCRLAMSSKWKERILGLVVVEPCTATATFKEWGEAKMKSWQLHAKGFTDSTNNYLMWHHFERKTGKPDAELVKNFIEEMKANINPHNLAAFLKSYMERNDIIKEVKACVKNKTISTTAHVMVVTGERSLHKELSEQFFRILSECDRKKYSILKPDCGASVLEEKPNTMAEGLLLFIQGLGLVPTLRTRSMSRTSSVGSTGRSTSMSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKY7</accession>
    <name>A0A6P8IKY7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC116302314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567454.1">
        <property type="nucleotide sequence ID" value="XM_031711594.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567456.1">
        <property type="nucleotide sequence ID" value="XM_031711596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKY7"/>
    <dbReference type="GeneID" id="116302314"/>
    <dbReference type="KEGG" id="aten:116302314"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="48"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031567454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031567456.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39887" checksum="A3BF4742991168ED" modified="2020-12-02" version="1">MATSNDSSTPSPQVANQTKPVLFRHCTGESSHIQIILIVIVMATSIFGNGAICGLLIRFRSLRTVPNILVANLALIDVINAMTNMPLFIMWYLCQVTFLKGPAVSWFIVSWYVLFMYLTVASLVVLMLDRYGAIVHGLRYHSWKTKNKAVIAVFCIWGSAVSYTFGMFSLGLDINVGEKPVWIYRKYYFKNFGRSFLIPGYLVPFAVIVVLGFLIWREVRLSSRQIGPQSNMGKRVRSDVETAKTLGITIVAYFWMGCFPVLLHSIARLHGSWIHYLAFFFIFMNSMANPVIYSLRTRRFRQAFMLLLREPCGTSQPTDSRFRQAHTSSTGTGMTTIGGSTKCNGASTPDNRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILV7</accession>
    <name>A0A6P8ILV7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM76B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567804.1">
        <property type="nucleotide sequence ID" value="XM_031711944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILV7"/>
    <dbReference type="FunCoup" id="A0A6P8ILV7">
        <property type="interactions" value="1995"/>
    </dbReference>
    <dbReference type="GeneID" id="116302607"/>
    <dbReference type="KEGG" id="aten:116302607"/>
    <dbReference type="InParanoid" id="A0A6P8ILV7"/>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF1">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="238"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567804.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37149" checksum="BC379146C782BA87" modified="2020-12-02" version="1">MLELSESKMSLFACTLCHSRHPFEELSKGDQLCKKCRKAHPLVTCIYCRMEFHLSGGTEGKPVCKKCNGYIKKHGQPTCCEYCNIRAAFNGTKCSRCESSERKYGPPIVCEQCKLKCAFQKSDESKDKVDGKILCLLCTLAYKRLVHKSKKEGGELLRGSNSHSHKRSLKREGSHHRHHHHHSKHEKRSKTEHNDVSGIGGSDVKPQGSAASGMGWDSPALGLYTNSGNSDAGAEPVMSDHMAELTELKELVVKLKKQLQQKNQALIEKEKKMTELKAENWEKEKEFKKKILSLQRELGERLEALQNDNRNLKKQLVVSSKSGKDKTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMM2</accession>
    <name>A0A6P8IMM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC116302847</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116302847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568094.1">
        <property type="nucleotide sequence ID" value="XM_031712234.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IMM2">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="GeneID" id="116302847"/>
    <dbReference type="KEGG" id="aten:116302847"/>
    <dbReference type="InParanoid" id="A0A6P8IMM2"/>
    <dbReference type="OrthoDB" id="6088938at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="147"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="290"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="409"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="531"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="636"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="722"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="806"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="915"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1049"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1160"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="185"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="315"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="328"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="434"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="447"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="557"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="570"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568094.1"/>
        </source>
    </evidence>
    <sequence length="1507" mass="167146" checksum="C510423FC1620689" modified="2020-12-02" version="1">MAKYKTIDFLVLVIFGLASAGIGLAFQWESSYTPNILHPGSSLTLRWSYTLTDREHQQATEFSLVVIEKERQIYSNQWQGIAVKIPFSWVKKKISQSSNIRLLQGQGAGIIFYNATDQDITRYRCTFLSGFSAPKKVIMPNIRVTIVRLVDSSRQSRGRVEIFHEGQWGSICYDGWDTRQAQVVCRMLGYPAALWHYGMRCYRDCSKIWLKNVRCNGNELSITQCDHGPWGVSNCSSGSRYAAVECQPLPVSTSSPYYTTRRPYTNWPTWRPYTTRYPYTANPSPGYNPVRLVNGNSPSMGRVEILHNGAWGTICDDSWGMDDARVICRMLGYSTVYRALGSAYFGRGRGMIWLDDVSCSGTEPTISHCRHQGWGVNNCDHSEDAGVMCAFSTWSPPLTGYTTSSYIYVRLVNGSLSSRGRVEVYYNSQWGTICDDGWDIRDARVVCRMLGYRDAYSAVGSAYFGSGSGKIWLDEVNCNGYESSISSCIHSSWGTHDCRHSEDAGVVCSTSTSIPMTSAIPPSVGNNTAAIRLAGFGSTSLMGRVEIYYNNQWGTICDDGWDINDARVVCRMLGNFTAARAVSSAYFGSGIGRIWLDDVNCVGNESSITQCGHRGWGVNNCGHSEDAGVVCQRPVPSKIHSISSTVYVRRGGYIYLYCYATGNPSPNVKWMRHNMTLATGISYARYRIFRALFFHAGTYKCVASNMFGSESNTTRVYVIQSPMNTIAYFNVSQGAAMIGEAVLIKCTTDAYPPATCDVYRYGNRLGNSGFIIPDVTLSDFGAYTCSCTNSIGSGNGTETLTLYENPTIQVIFPKTQNLSETGSFEIFCNATGNPLPKIYWFHSGNHSKRPVGFGNTLSISNSSLDDEGTYTCTADNRRKQAKENATVYLIYRISRITNPPKDATVSSDIYRRYYLYCNVTGIPKPNVTWFKVGKQTPVGGGAVLTLFARWNYSGIYECVAENGVGGAARARASYQVLHKPHSTQLKTNRDNNVVIGNAPITIICTTIANPPADHYDIFLGNKHLATSSSGLYVIPKAKAEDKGTYSCFPRNTVGSGANATMELHVFGALSIISAPQNTTGIEGRKVTLYCNASSSLYNVQLPAIIRWKKVGENDVHFPDGEKLVLEDVRPKDAGVYECDARNGIAFPDVARATVIVHYKPRNTKLTLSTGGVYIHVNESMSLVCNADAVPPAFNFRFYHRGVKIGESSSHMFNVSRVSSSSNGTYSCVAENSVGEGPTASITIKFTSCGRRTYKSSPQTRIVGGDPSHHGGWPWQVQMGGLLYGIFFPHWCGASIVNERWIVTAAHCVTRRRFGSYTVFKPKNLTITVGEYNLSRIDGTEQQIPVEKVLVHRQYNPTTIDYDIALLQLKRPMVFNAHVSPVCLPSFDFPPNTMCYVTGWGRTTMANRKSSIVLQEAEVPLMERNRCKYLLRRISTVTSRMRCNGYNGFPKSTCHGDSGGPLVCSRNGRWFLMGITSWGYRDCTDMRYPSVYADVLYFRDWILNTITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMN1</accession>
    <name>A0A6P8IMN1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116302986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568286.1">
        <property type="nucleotide sequence ID" value="XM_031712426.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IMN1">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="GeneID" id="116302986"/>
    <dbReference type="KEGG" id="aten:116302986"/>
    <dbReference type="InParanoid" id="A0A6P8IMN1"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="422"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="722"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568286.1"/>
        </source>
    </evidence>
    <sequence length="965" mass="107353" checksum="109B49A86ACE24B0" modified="2020-12-02" version="1">MNFDVLKCEPVSQGVIDTQTNLILLKAIEKCTETETSKITTDLDEFASSTNINMLSLLVADFTTPLHGIWCDRPQKRCKTAKLKIQVSGWQGLHQSFLDXGYHGSKHDMNSSHCLYVSLATLMDIGIQNGSWVKIWIHESLGKIANVSGQNDNQLTHGISHTTNKQIADTNPNEMKVVYHYAQLYALDYQGSILHAYAKSPQISVFQSSNSVNQIIHVSPLLYFNLINNSSNPLQDPKELFLRLIPYSFEKKDIKVSDDEANEPVQDSVPPYAKEAQLFLVQTVFTRPGYAFDKILERHFSKPRVLTVGDIFCIKFDGYKDSMYSLSSELDGQRIENCMVYFKVMKLACTESEKVPCLVDVDHTTVYQASSVQSFVHVVLHPKEDLKVKTSYWDLPTPPGLEVATEGLKSIIKPYLRQNVQMMPAVLVTGPLGAGKRTMVMAIGRQLGLLTMNINCYDLIGDSVAATEARISNIFQKAIACRPCILLFRHINVLAKDRDGLEDEPRIACTLQQSIKDLQKLSNWPVVVIATSSSSKMSAQVHSCFLHEVKVKTPSENERKRILEALASMSCVAGDVSFGVLSKRTAGLVLADFVALFAKATGVASKRISRHYGCLRDDSTFVEFSRLESYNKNDWRNTIEDRGCEMDNLCKDVLRCGPKIILKDLQDALEEIQGEHSDAIGAPKIPSVSWQDIGGLADAKADLLDTIQLPLQHPELFASGLRRSGVLLYGPPGTGKTLLAKAVATECSLNFLSIKGPELINMYVGQSEENIRHVFSRAQSASPCVIFFDELDSLAPNRGRSGDSGGVMDRVVSQLLAELDGLHKSCDVFVIGATNRPDLLDPALLRPGRFDKLLYLGISEDHESQMKILKALTSKFELSSDCDLESISKHCPLNFTGADLYALCSDAMLRSIKRCLHEHQGIDEEIDSDILVIEEDFLEALKGITPSVPEHELQRYERIRQHFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INH2</accession>
    <name>A0A6P8INH2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat family A protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568419.1">
        <property type="nucleotide sequence ID" value="XM_031712559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INH2"/>
    <dbReference type="GeneID" id="116303104"/>
    <dbReference type="KEGG" id="aten:116303104"/>
    <dbReference type="InParanoid" id="A0A6P8INH2"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568419.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48812" checksum="C25B170F8CB08B35" modified="2020-12-02" version="1">MSTIELEWTSFIQQDNFPKNDGQSVSKASKILPKSIKMKNKKRIFSPVKTCPHKGETDGAQVYPQLTERCWTQADNMVEQIAATDGENQLSLAESSKPSLNTIRCGDDNLNLKVLKTTKAEEKNKDDQKWTSDVIFEAEQIVMKSEIDNIQVNKPLLKKKEETDEGILREPLGEGMKAEIPSLVNLETFSASPTHSKSCNSSVERRGMYFRSEEDVNSKTSSIVNVARKISRSTSRSLKSLNSLRRFVKISDKNVPMSVKQQQSEEGAYALLRAAKNDSVFQIQTLVTHGISTEIIDQRGWTPLTIALENENMKCAEVLVEMNANANFVHANGMTILHHITSTGTYKGVKFLLRHGANVNAENSEGWPPVHYAIKQQHLKCAALLLAAGCDSQTYTHKRLKEYEEVVRLATIGKWKYHWQQKLDIDMSNEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPQ3</accession>
    <name>A0A6P8IPQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116303041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568343.1">
        <property type="nucleotide sequence ID" value="XM_031712483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303041"/>
    <dbReference type="KEGG" id="aten:116303041"/>
    <dbReference type="InParanoid" id="A0A6P8IPQ3"/>
    <dbReference type="OrthoDB" id="5987037at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568343.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69904" checksum="5A211A232259765D" modified="2020-12-02" version="1">MCRLKSYSLSQKCVWRLVCFTGSILLVLGAASFGFGMKLIEFAEKTDVTPVFAGIPMMLAGFLGLASGLCKKGWLVTGYGICCVIISMLSIHMNYRFMGKELPSLPIYREQCMNEPKVQNHCDRYIGTVALCSTAVLMLPFILAAILSCVAAKRILKKKNCCIFWFTCSKVEPSLPIYDVKLHRYKNRQKTNPVGLLSYKSNTSKGFVCEIPETRPTAEYLPRIPDFTDLAGXPDSPGYPASFMFEYENKNSRASGECRKNNYGHSKTKEQSLSLIGSGLTTEDDXGTAHVQRKRRSNSVPHGVATSEVDLRLLEQDYLNRRSYLEEEENEKYYSFAAEEWIQKMVEHLHDSRSRLYAVSDEEDLNEAPRRKESSERTDKHWCQASTESENQEELSNRMGSPPQKQLSDVGRNVDDGSARKMSLKTESCINSNPRTTVERELSSEPDKNYIDKGKLSRDHNKLTGSVPRRRKLGASSPCDIEQETNYDDDLVSQLPTLKSNNSQSEVSTTDSQSDTSITDIQSESSANSQSKSLDNNKSGKVAEEASIEYFGTKDLTPHGIVTPVGQPFPTGSLYFEFEKAAPTEHAQKNWVEFEGHPEGKEKLLKGEMTLKEYEELTSYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ32</accession>
    <name>A0A6P8IQ32_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="22 23">Mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">LOC116303581</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22 23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569008.1">
        <property type="nucleotide sequence ID" value="XM_031713148.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569009.1">
        <property type="nucleotide sequence ID" value="XM_031713149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303581"/>
    <dbReference type="KEGG" id="aten:116303581"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653220" evidence="14">
        <location>
            <begin position="24"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2124"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="202"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="319"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="544"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="657"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="766"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="19">
        <location>
            <begin position="985"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="18">
        <location>
            <begin position="1166"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="20">
        <location>
            <begin position="1298"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1702"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1749"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2156"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2180"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2214"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2232"/>
            <end position="2241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031569008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031569009.1"/>
        </source>
    </evidence>
    <sequence length="2259" mass="251811" checksum="20B8BCD9B2280153" modified="2020-12-02" version="1">MVVILLSTAVIFAVLLPHEVVVGKVSEDVFPSPYASSKADWGQESEPLPDSRSRMRAMPRQAFTDVPPGQECSSYRNLSSPDRAQRAVTSVDAEICDRNHAFSSGWYRFTGDAGNKMATSCVPILRCMAASTGWLNGLHPTSSTIVKNEVCFNWKQDCCSIKVNVRVKLCRGFYIYELPAVPQCYLRYCGNALGPMEKPSQCGGNLTSLTGQITSPGYPNYMEPITCQWTIKSPFDGYILLYFENITLGHGGCFSNNLTVEGDRTETFCYRRDLNSFSILVPKRTVNIYYKSVYWNKKLGFKLKYLMLKENLDNAQAHSQWNISAQVNGPSSIHVSWKTFDNSVMSSGQTLYGVVVVCKPLKLIQRTVHVMVQHSATQVEVTGLTGGTEYTVQVVALVNDPNMVSVSLYGSDTARITTSDGECETYRNLTSERRSQSEPGGPYCDQNQIYTPAWYRFGGKAGTQIATSCVPPDRCHTSSPGWMDGTHPLVQDGVVMRTVCFHRLEDCCRWEVTIRVRNCDGFYVYQLHRPPMCKLGYCGNDGGCGKFIRDASGTLTSPGYPKRIYWNSKCLWDFTAPSSAGVIVVVVEDLRIPCVKFSLSFQNGVGKQVGQECGIQRFFTWVSQGSAKLKFLSDKAESRWVGFEARYFIFNGSLTDIPDIPQWSGVSAQALNSTAITVQWGPYSNISVTEYLIICVPDGLPLNATISIKEYAKVSQFSLVVSGLMEYTNYTVQIVVQTSDAKSSFSGYRGSQKTRVETKEDVPSEGPSDVKATSAGTNRIMVSWNPIPKHAHNGIITHYVIYYKKVLTAQTWTEMAVNKPLINGTRMIAYLERLEPGKYVMQMAGATSVGVGTKSFQIYFILVLPTTILPATTPPLTPDKALRMYPYGESAGDSMIPNTKYYVATCFRIDIPGDGLPFFTKRHHMIHICRNGLLLFETWRSIRWPYRLVEERTWLRDASLLAPYWALIDVDGSFVNRGISKVYYQAYNDTDNSYKSRKMIIQATHDVENLHLNKLKLYEGDYTKPRNFKAKWVLVITWVNLRPYGVERLRNFNLTNTFQAVLITNGIHSFAMYNYPTNGIQWAVPAPLGKHHLYEGSPALPVAGWNVGRKSLEHYDIEGSGQTAMVGIDTRYGKTVKIDLRKKKKVPDQISKGKWFFRLEAALSRGGVTPKDRCIDWYKAHPDHADYTEKLVPCPCTKNQAEKDSRFKMDSKGWPFICAKSVFPSNEGWEQKCCYSQFTRALVKGYPGGGYPISSISYTSGLKHDEFAYVKCCVESSTCNLFYKKRPSDDCWRYLHPQLCWFLGDPHFVTLDGLNYTFNGLGEYIMANISNGLFQLQARTKLVEGGGKATVFVSAVARQTGSSAVQVNLKSAGGLEVLVNGSVIDHSTLTNTTTRYNGSVALSRPDKASITVLFPCGISVKMTDVKGSLAILLAAPERFKNKTRGLLGVWNDYPEDDLTTPTGRVLPTNAKGRTIHYEFGQLWQVTESTSLFTYKEGESVNTFSNSSFEPMFIEEYNFTSDAVKQEALEKCEGDVNCLFDAALTNDVTMGTSTKIVGSNFKNESEAMKNKVPIFVNHSSFINVTVNTTARIEIFAKDDDGDPLTFYVSGVLPETLDNTTSNNSIVVSWKVTMDKIQLEFTVMDDKGAAALWRPKVYVCACHNGGYCSPDSSNNIFADSTNDTFLIMPCNCIHGYTGRFCENDLDACQANLNPCYPGVKCTDLPPPADVSGYKCGLCPRGFTGDGASCLDLDECEGSNGGCSQICVNTPGSFVCDCNHGYRLSIDQKTCNDVDECIPSSDCMHKCKNTIGNYVCECNEGFEVNPNNRKECVPKIPCTAGDHDCKHICYIKDGRQQCACRQGYKLMDDQKTCEDIDECEPKIKRCSQYCNNTVGSYKCWCKNGFRLDKDLITCVDVDECMELTYQCSDPSQLCRNTEGTYKCACGEGLYLTKNNTCREIEGPISPEKPDPPKLPTENERKNSINITVQDLNVDKWYKSLDKSFKDAVAKAVTYYCANKDEDCKKERERERRALDYVLYTADQVHLLPDFPKQINLRSRELAAVIAFYVEFPPEVVSTSGDSIEGGILVEIVQFAKKDIEKSLNRTISSITSNKKEEPSITEEPEKLNIYVIIGVSVGAVVLLVIIVVLVRRFACTKRPQENTKRVGSSPGINNQSFNPMGEGEGEGEGEGEGEPIELRPVSMENALEDSGNQYVEIGRDNPDVDHSDVAEKPQSDVTFSTQAEYSEIPAKPGLEGHYEETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQD6</accession>
    <name>A0A6P8IQD6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Octopamine receptor beta-2R-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116303264</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568635.1">
        <property type="nucleotide sequence ID" value="XM_031712775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQD6"/>
    <dbReference type="FunCoup" id="A0A6P8IQD6">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="GeneID" id="116303264"/>
    <dbReference type="KEGG" id="aten:116303264"/>
    <dbReference type="InParanoid" id="A0A6P8IQD6"/>
    <dbReference type="OrthoDB" id="5968184at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031568635.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34903" checksum="A9526B940498F844" modified="2020-12-02" version="1">MTTALSKKDIPLLMISIIAVVANLFVCVLVFAKRRLRTRTNKFVVSLAISDILIAGILLPICLAQVNPTVIAYMGSITLLAGVANISVVTIDRYIAVFKPFRYSEIMRLWFAKIIVLAWSLSIAVSLIPLFWNTDPTTTAHRVYIYTAQIGLVVFSYVLIFVAYIRIFRKVHQTVKKERILMLSLAKSHGQEFENNSRASPSSSESKVARVSIIIAANFMLTWLPVEYMTFMGNLGKEEYIPESLSSISFYTIALGALIDPMVYSYLKSDFRQAIKSLFVKRSRENEMSSTQGFLGQTRRLESGQRSTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRR3</accession>
    <name>A0A6P8IRR3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304061</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569572.1">
        <property type="nucleotide sequence ID" value="XM_031713712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRR3"/>
    <dbReference type="GeneID" id="116304061"/>
    <dbReference type="KEGG" id="aten:116304061"/>
    <dbReference type="InParanoid" id="A0A6P8IRR3"/>
    <dbReference type="OrthoDB" id="10308567at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569572.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="79369" checksum="878C991EF8FD0828" modified="2020-12-02" version="1">MVCFPLQLTTRVVRVKQQKRSNEESYFESWCMCNGFFFLLLLTSGQLFPKAEDKPKVTENPFIQGQESQAEPRSVPFIPGQEYQKFDYKVKVIRRRKRSGVRGRRKRRPKIRGDLYDEWTAESPQTVDDVGLFTRLWRWLCSFFTWKTTSTTSQRDEFKEVCKEDVEKTARQEDAGVRIQKELDDKVVVVVRDEKGDYKETTTSDIRDEELKLENDITEEENNDCIVEQKVAIQKDDKSNMEDGCTTKTVASKCCPVRRLETHVLQKTDKPKTYNVVPLKQLESKVQMPVRTETVASQCCPIRRLETHVLQKTDKPNTYVVPLKQLEGKPSTQLQVTEASLEVGEAKSHDVSTSSCYRKEIWDTHVLQKTDDPKTFNLVPLQKKRLQDGKVAKITSWSKDVIPNTSTRDAQLQSSGLSTPRLLPSKGRSTFKDDSQPDRKSRENNQKKDHMTSTSRSYHKPKKNSRYSNSKRTGGPSCREELGLSWRNQSKESAESSKGHMYLSWRQKECQSSESSSSSLSWRSSSSKGDMSSNWRQHDYTARSSSRTTQPLSWRKHKENTRDSPNEEMLYNWRNDRQTKVPSSASNWRITSESRPRKQRNNTKEKSAEKLYQVKPEKESEQKVVKECMPRKTYAEAVVRGGSGPFTSVRNSPVNTALNTRRVEPRAWASKGRRRNIPRRSERHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISR4</accession>
    <name>A0A6P8ISR4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116303801</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116303801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569263.1">
        <property type="nucleotide sequence ID" value="XM_031713403.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303801"/>
    <dbReference type="KEGG" id="aten:116303801"/>
    <dbReference type="InParanoid" id="A0A6P8ISR4"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF420">
        <property type="entry name" value="DELTA AND NOTCH-LIKE EPIDERMAL GROWTH FACTOR-RELATED RECEPTOR ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027606181" evidence="3">
        <location>
            <begin position="20"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031569263.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="58855" checksum="6151D9D798B541BC" modified="2020-12-02" version="1">MRFLVSLFVFVLLIRFSKALKNEILARKGSLRRDTVNKFGYARFVKHENSYLDVSVAFNSFVRRAGECAFICANSSIGFSFNFAINADIHGRHICEILATDKYNASDKFSCQPGLNHYSIYSPCSSFPCRNGATCKAIYEENKYECLCKPGYNGVHCENGVDYEMDVALHGHSYENVTVTNIKECLTTCLNECRCMSYQLFGTRCELLDEDRHTAPADFVPTPGYKYNEPKPKTTQGSINCATSGTPASMSSLNCSNGCCQNITCLNGGTCIEQCSKDVRPKFQCLCIPGIFTGRMCEKPMTCAAHGKGLVSGLYPIALPSGDKMNVYCDFHSQPGFVWTLIESFGFANMLKYRYKSFIRDFPVNQAGTFNWTDYRLSRLVMLHIRSNSTLFRATCKYETDGLVTRDYIRGLLTNFDIIMRASGAICAHVXYINVRGINCTECTTHLRQVTSLHVLVNSGFGAGMGCEWDGSQGMMTITKTTEEGRKIKYFDVNFGAYFDPVNPAHRCSSSPSSTTQWWLGTPEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUY0</accession>
    <name>A0A6P8IUY0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116304369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116304369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569958.1">
        <property type="nucleotide sequence ID" value="XM_031714098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304369"/>
    <dbReference type="KEGG" id="aten:116304369"/>
    <dbReference type="InParanoid" id="A0A6P8IUY0"/>
    <dbReference type="OrthoDB" id="406800at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027761738" evidence="2">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569958.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="33676" checksum="2A905E0F558F3882" modified="2020-12-02" version="1">MKSWVFPLAVCSVLLSIHAGSISRQKRGYLSRTGLCPDPASNFQKKDVRLNYMGMAVIREGDSVDPPCTESECNEDSHCDGNRKCCKNYCGAAVCTVSMRDPNPCAGFNCPTGQACKVQKVKCVMPECPVATAINRPTCIPKETLQETNTATLGDFQPDTSEVLQQYNAMQMQNDATKSDNSYEXAXSDQSDATSDTAPNVDGTADVQTPDSNLMQAPMIETAAGAQSNDALSFTDQQQSYASPLEQTSAPAVPTDTDXFTQTPMDNANYAPIPSPDIASFQASQDSIPVADQPSPDVQVVAQAPAQQLSPLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUZ1</accession>
    <name>A0A6P8IUZ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570757.1">
        <property type="nucleotide sequence ID" value="XM_031714897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUZ1"/>
    <dbReference type="GeneID" id="116305062"/>
    <dbReference type="KEGG" id="aten:116305062"/>
    <dbReference type="InParanoid" id="A0A6P8IUZ1"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031570757.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21785" checksum="945BA1B38341340F" modified="2020-12-02" version="1">MALHWIQQVEGGPRRVNHAAISVRDRFIFSFGGYCTGEDYFIIDKLDVHIFDIVTCRWTKFPTPSRTDEQYDCVPYMRYGHSAAVINDVAYIFGGRNDKYGACNTLYCFDTRTLTWSKPQTYGYPPAARDGHTACVIEQKMYIFGGYEEEVQYFLKGTTCTKGNLKIPKSISVLWLTSPQSISCHITTLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW88</accession>
    <name>A0A6P8IW88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Translocase of chloroplast 34, chloroplastic-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116305548</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Plastid</location>
            <location evidence="17">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571344.1">
        <property type="nucleotide sequence ID" value="XM_031715484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW88"/>
    <dbReference type="GeneID" id="116305548"/>
    <dbReference type="KEGG" id="aten:116305548"/>
    <dbReference type="InParanoid" id="A0A6P8IW88"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF135">
        <property type="entry name" value="TRANSLOCASE OF CHLOROPLAST 120, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027785116" evidence="18">
        <location>
            <begin position="22"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="19">
        <location>
            <begin position="53"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031571344.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31865" checksum="6B6F7BD6EE1484A2" modified="2020-12-02" version="1">MAVNAVNLAFISLELLSFETAHLPSLRHDNQCSSTDIQDVVVEFKKWFFDDCPQTLNLLITGKTGVGKSRLVNALVGKKVAKEGRALDPCTSEVTSYKVVIKGVAVTVWDSPGLQDGTSNEDQYIEDMKKKIKDVALIIYCVRMDDTRFYDEDKKAIRILTEEFGKDLWVNAVVALTFANKVEDPDEENDLENFRFQFREWKKQLKDYFAAVGLNPETSRLIPIIPVGNKVKSMRLPDRENWLSALWIECCLILKLCPVSLIGFCYTCDRGFYCPKWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXM2</accession>
    <name>A0A6P8IXM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter AVT3C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571847.1">
        <property type="nucleotide sequence ID" value="XM_031715987.1"/>
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    <dbReference type="GeneID" id="116305974"/>
    <dbReference type="KEGG" id="aten:116305974"/>
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    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF700">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="109"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571847.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="57005" checksum="DA2D727228251337" modified="2020-12-02" version="1">MTRYKSVPSVATGVTVIRPTVFRQITDFANIFKSFIGTNWIALPFAFRQSGLLLGCIGLILIAMATDHCSHLIIKCKKAAVKKVLLSNPKYTDPSTSEEELEEIRDATEKKVMYGDIGRIALGKLGVVLVEVSLLATQFGFCIGYLIFIGNTIGSLFPVNTLLNVNSSQAHNSTDYHLDTKSTAPTFAILVLIPVLPLILMAFIRRVRKLGPVSFISNVSLLIAFTSVLGYMLSGLTFRIKDIKLAKWATFPVFFGQVTSSYEGMGTLIPIETSMGDNRKRYPLYLHLAIGIISLILGGFGIAGYLVYGDTTEQISTQMLPQGQPLVIIVQILLCLAILFTYPLQLYPITEVIESYIFKDGNVKKPPSDIEGQNDGDQDTSENEPVNEELIDSNSIGPGIACVNDIDETTELLSATDNKMKKPMKKKPNWRKNVLRTLLVLLTAGVAIALKDDFAYVGALCGSLGSSTLGFILPCIFHNVLLKETNSKLTVAKNYLLQLFGVVGGAVGVAVTITQIVKQFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYF3</accession>
    <name>A0A6P8IYF3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Antigen peptide transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572199.1">
        <property type="nucleotide sequence ID" value="XM_031716339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYF3"/>
    <dbReference type="GeneID" id="116306308"/>
    <dbReference type="KEGG" id="aten:116306308"/>
    <dbReference type="InParanoid" id="A0A6P8IYF3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="223"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572199.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43416" checksum="3149326529151982" modified="2020-12-02" version="1">MEYNNIGRAKEASKEEETGDQVNVIFYTLPKYRFTILMQVLLVLDLASSVTLWLCGGNTKYMEDHVTNFTIRDSVIDLAVLSFIRCGLLFFIYGFLENISLKQIDHPYESSLSTKKCIWHFIILFFSIGSLAFSITKGVLIYNVRSDSAHHLHSTYYALVISALCFCFLESVGAVLSFHAMRKLKIMRILLTPNDKENEEKPKKKVSLGRLATLTKPEFFILFVASLALLVSAGSQIAAPYFFGMVITAAMEPGMKKLNETILILLLIYIGGAIGSMIRAWLYTLAGQRIVARIRKQLFNAIIRQEVAFFDTNRTGELINRLSSDTQVIQNALTVNISMLLRYVIQILGSIVFMFTLSPKLTGVLISVVPIIGVGAQQYGKYVFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYP0</accession>
    <name>A0A6P8IYP0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/arginine-rich splicing factor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572631.1">
        <property type="nucleotide sequence ID" value="XM_031716771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYP0"/>
    <dbReference type="FunCoup" id="A0A6P8IYP0">
        <property type="interactions" value="2208"/>
    </dbReference>
    <dbReference type="GeneID" id="116306684"/>
    <dbReference type="KEGG" id="aten:116306684"/>
    <dbReference type="InParanoid" id="A0A6P8IYP0"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001074">
        <property type="entry name" value="Splicing factor, arginine/serine-rich 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF3">
        <property type="entry name" value="SPLICING FACTOR, ARGININE_SERINE-RICH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572631.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17777" checksum="6BA0846829C20463" modified="2020-12-02" version="1">MPREESARVYIGNLGSNGVKSELEREFAKFGSIKDVWVARNPPGFAFVEFHDHRDAEDAVRELDGRRICGVPVRVEISTHKGRSSRMPPPSYRGRPRYSPDRYGGRSYNDDYGDRYSRRSPPRRRYDRSPETDRYQRRYSRSRSRSPPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYQ8</accession>
    <name>A0A6P8IYQ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116306397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116306397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572307.1">
        <property type="nucleotide sequence ID" value="XM_031716447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYQ8"/>
    <dbReference type="GeneID" id="116306397"/>
    <dbReference type="KEGG" id="aten:116306397"/>
    <dbReference type="InParanoid" id="A0A6P8IYQ8"/>
    <dbReference type="OrthoDB" id="10472284at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031572307.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11184" checksum="7BEBAA6AA5B27CCE" modified="2020-12-02" version="1">MQSTQNSNYINARNWLPEQKNYDIGSSITLICKPRFKPESKSSVMCNSLHASFCHLPSCKDMDECVVGVQDINSANCIAHVITMLNVATPLVHINECIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J089</accession>
    <name>A0A6P8J089_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116306867</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572854.1">
        <property type="nucleotide sequence ID" value="XM_031716994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J089"/>
    <dbReference type="GeneID" id="116306867"/>
    <dbReference type="KEGG" id="aten:116306867"/>
    <dbReference type="InParanoid" id="A0A6P8J089"/>
    <dbReference type="OrthoDB" id="9994028at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572854.1"/>
        </source>
    </evidence>
    <sequence length="1132" mass="128841" checksum="E0B0E6CA8FD1CF9B" modified="2020-12-02" version="1">MTSMKYREEDLNYFRVCKVTTHIIPNGLRQVFKQEWNTRYQATHGQWQDTAKNGMDFYGRESPKNKKIKSRELSIMKNGNTNEWDCTCLFHGILYSNSIKPTLNVKKSVDELRKFRNEVFAHTTDGKLKEADLKTSIDKVITSFTDLKLDTTEIEEIRNQTSFPTEELEDIKKQLEKEKKRNEEPRPFCVLPAKPSHETVSRLNEVDQINEEMERLRNTKSNEVTVVYLSGNPGCGKSEVARQIGERFFDEKSTEMNFVMTVNASTIDTLLQSYVEFACKLRCDEQSIVKISTSENLSKEGKVNDLKCLVAPKVEGYSSWLIVVDNVSDLKSVSKYWPQAGEKTSGVGQILVTTQDSSSIPSDPHTYQLSLKQGMDPNDAVKALCDISGMSCHNDITLQVAKALDFQPLALACAAVYMKHIKSTDWTKYLQKLEEGKREATEKEYKKTSLTYKKTMTAAVRMAVDKEVSEDKVMRHAFEFLSVIAPEPIPLQYVVQYVMNCLSDEDEDCVASTIRSSSLVLSSEKDEVQEVRVHQVVHSCLQSTVNVDEIEFKVDILIINVVLAFIDPVTSVEALEYIEGILETQRLIVHFLSISSKISDIFDDPSDLAISVSVNIFHVIASLLKIGDICSYYAKYDACRIFYKISLKIQEKEFNRSCLSIAETLNSLSKVFRNLDQNKPAEGRSERASAIRKRQQTFSFCRQTDNTQTPMHNVNVYDKGGKANELITLGNSCLNQKNFMRAKSFFEEALGIQETMYGNSHPLVASTHNKIGETLCLMKNDEEAKTHFEAALAIEDRIYNFIISILDFSLYALAKLFWDKGQYDNAEKYIEKAKEVLNLKEKEMHPSLGDALNYAGKTLCMMGKYDDAKRCLETALKIQDGMPNDTQAEKLVTLLNTRGEIMREMGQYKESKTNLSRALEIQKKESPSFADTLKNLGKTHVAMCQLNIAKECYEQALRNEQNAYGENDPRIINSINELGEILRLMGKYKDAEIYLKKAQTIQEKVAPFHKKTHPNFANTLKGLGDVLYDKGKSEEAKHILQKALAIQEDAYNTIHPELVDTLYLMSDTLLDMRKYDEAKKPLERALSILKQAFNDEHPDVATPLNKLAAICRNMHQYEKADGYLKRVLNIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1B3</accession>
    <name>A0A6P8J1B3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aflatoxin B1 aldehyde reductase member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571590.1">
        <property type="nucleotide sequence ID" value="XM_031715730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1B3"/>
    <dbReference type="FunCoup" id="A0A6P8J1B3">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="GeneID" id="116305747"/>
    <dbReference type="KEGG" id="aten:116305747"/>
    <dbReference type="InParanoid" id="A0A6P8J1B3"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031571590.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37044" checksum="41D352659F4ACFFB" modified="2020-12-02" version="1">MKTVFGTMEFGRQADPIQAKEMVKMCMNSDCYEFDTAFMYAGGKSEEIMGTIDLLKDPKVVIATKANPWSEQGLKFDRVLEQMNTSLHRLQRKSVDIFYLHAPDHKTPIEDTLKAVDQLHKEGKFKQFALSNYAAWEVVEIYYICKESNYVLPTIYQGMYNAFVRAVESELFPCLRRFGIQFYAYNPLAGGLLTGKYQYSDKDDKQPFGRFFGTGPWAESYRERFWKKPLFDVLDKLKVKLNEIYGEGKVSPTEASLRWIYHHSLMSEKYGDKVILGASNLVHLEENLKASKQDVLHEDIVKIFDEGWESMKGQCPAYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J254</accession>
    <name>A0A6P8J254_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305918</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571780.1">
        <property type="nucleotide sequence ID" value="XM_031715920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J254"/>
    <dbReference type="GeneID" id="116305918"/>
    <dbReference type="KEGG" id="aten:116305918"/>
    <dbReference type="InParanoid" id="A0A6P8J254"/>
    <dbReference type="OrthoDB" id="10323888at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571780.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39602" checksum="21EC848033CE8E43" modified="2020-12-02" version="1">MASRRTYTTNNQEDGDYVFLTSGFTEQIPRPTTFNFNQEDNVIVAERQHPPFTRTSSFERSGPHSPVYATDPRSIDSNMPYTTVDEYTTTYTRITRSTENLDRLPKGDEQRLIDFDEFESLDGSKRTHSFTFDELGNDLLSQGIGSDILESTDRSPFRTPRRSKSLTSFHDDEDQDYGFVAAPRAKPAKLGRLGRSYTSGGNVLKSVEKWETGQREAVEGVEERRLLRSKSERALNGRERQISPETENTLMRAQSWKDVDGNGRRSNNVQYVGTERQEEWRKGRQEQVDSQTYKHYISEFQGTESQNRIRGISPHHSENGKKRSPYRIPTSPPASEFLFPAFQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J274</accession>
    <name>A0A6P8J274_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116306310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572203.1">
        <property type="nucleotide sequence ID" value="XM_031716343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J274"/>
    <dbReference type="FunCoup" id="A0A6P8J274">
        <property type="interactions" value="2460"/>
    </dbReference>
    <dbReference type="GeneID" id="116306310"/>
    <dbReference type="KEGG" id="aten:116306310"/>
    <dbReference type="InParanoid" id="A0A6P8J274"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="201"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="309"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="465"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031572203.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="69252" checksum="49FFDEC916C68B73" modified="2020-12-02" version="1">MAISLSEGAIHDIITKPAEQHPPKPVVQVLGVRKIQANQAGKGTDRYRLILSDGALIHTSAMLATQLNDKVTEGEIEMKAVIRLDKYICNIIQETRKVLIILDCTIVKKACDVPGKIGNPKSSADLNSGQQQAQENGHQKSENGSFGGRQNAPPQRQPMQQQGRGFGGGGKYGSHQPVNRGGDGHKTVFPISGLTPYQNRWTIRARVTSKSGIRTWNNSRGEGRLFNVELVDESGEIRATGFNDAVDKFYDLLEVNKVYYFSKGSLKTANKQYSSLKNDYEMYLNNDTVIEVCTEECDLPTIMYNFVSISDLENINKDTMVDILGVCINAADVTQITTRTTNKQVSKRDVTLVDRSEKSVTATLWGEEAEKFDEHVGKTPVLAIKGAKLSDFGGRSLSILNSSNLRINPLDLKEAMSLRGWYDNTGKNNELQSISNQRYDGGSGKMKYLSQIKNEQLGMGEKPDYLSAKGVCVYLKRENCLYQACPTDECNKKVIMEDDGFRCEKCNKKFPDFKHRLILSAHLADFTSSQWVTCFQESAEMILGHTAKEVGELRDSGNEGAFDQLFANAEFKSYVFKIRAKMETYNEETRLKCSVVGVKPVDYKQDSKRLLEDIQRLMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2G5</accession>
    <name>A0A6P8J2G5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase mitochondrial F1 complex assembly factor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116305981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571860.1">
        <property type="nucleotide sequence ID" value="XM_031716000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2G5"/>
    <dbReference type="FunCoup" id="A0A6P8J2G5">
        <property type="interactions" value="2425"/>
    </dbReference>
    <dbReference type="GeneID" id="116305981"/>
    <dbReference type="KEGG" id="aten:116305981"/>
    <dbReference type="InParanoid" id="A0A6P8J2G5"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031571860.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33477" checksum="063F21D349555EB7" modified="2020-12-02" version="1">MLSRRAFSILINSSQPLTSVNSCASSFWKEKCLFKSRTEVILQTTRGLSSFREKKRFYKRAGVEQSNEGYQVTLDERKVKTPSRKPLVLPSKQLAMAVAAEWNMQKDVIETSNMNLTTLAYITIDKPNPRTKATQITEVLEFLCTDTVCFPASEPEDLVNLQKQEWEPIIAWFNARFNARFDVSVESFGNLLVPSIPKDTTSKLTSHLMTVNDWAMTGLEYAVDTSKSFIIGMALLENHINVEKAAYLSRLELEFQIGRWGSVEWAHDVDLMEIRSRLAAASLFYHLCNKEITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2L7</accession>
    <name>A0A6P8J2L7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 65-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116308022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574231.1">
        <property type="nucleotide sequence ID" value="XM_031718371.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J2L7">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="GeneID" id="116308022"/>
    <dbReference type="KEGG" id="aten:116308022"/>
    <dbReference type="InParanoid" id="A0A6P8J2L7"/>
    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031574231.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30766" checksum="4C765119294F7191" modified="2020-12-02" version="1">MCISDRKNRMGIRIFNILLQDGNWRQAEPCFDLVVWGSCGIVYMNPVPLLDSSTLIMGLYCGCGRISLNISLYFSISKHLTHTYRKPSLHQVIRXYYRGKKSGIAEICNVSEADSFVSSLTTKERSFLQEALKQHQDDEPEEVPTAPTVAQLRLAAFHSAIPFIGFGFLDNAIMITAGKNIAITLVAALGISTMAAAALGNLISDVSGISLAHYVELAANKMGFEGPGLSSKQMEMPRTRFITNLGRAIGISFGCVLGMFPLLFLSSKDEEEKKPHNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J361</accession>
    <name>A0A6P8J361_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">mRNA decay activator protein ZFP36L2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116308167</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574411.1">
        <property type="nucleotide sequence ID" value="XM_031718551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J361"/>
    <dbReference type="GeneID" id="116308167"/>
    <dbReference type="KEGG" id="aten:116308167"/>
    <dbReference type="InParanoid" id="A0A6P8J361"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007635">
        <property type="entry name" value="Tis11B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04553">
        <property type="entry name" value="Tis11B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="162"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031574411.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33664" checksum="C7B7CBD4CC53FBF0" modified="2020-12-02" version="1">MSTALVSAFYDVNDVVYKNNKNLGSSPFDFRPRNDRRVVAPPRRHSTNSTTRQTSTNLITLSSLSNKQRERSLSLSTATSIQSEDDPRRNSQGSSRYKTELCRPFEESGTCKYGDKCQFAHGVHELRQLSRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEEKRAPPPNSPRSPPPLSPLNGPPSPPLTDPLSPLSTSLTPPSPSPLSFYNDESPLSSPIDSPLPMPMSSSPSVNNVFKFPSPTQEYSPVISTTAVGSPRFTPSISLKTVEEERDDLPPTPPEAFDAFGRRRLPVFNTLGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5M7</accession>
    <name>A0A6P8J5M7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melanocortin receptor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575004.1">
        <property type="nucleotide sequence ID" value="XM_031719144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5M7"/>
    <dbReference type="GeneID" id="116308669"/>
    <dbReference type="KEGG" id="aten:116308669"/>
    <dbReference type="InParanoid" id="A0A6P8J5M7"/>
    <dbReference type="OrthoDB" id="6144223at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="158"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031575004.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32523" checksum="C155A9593CA9B27C" modified="2020-12-02" version="1">MALLASSLNFLTIFTFVKTSSLREKPSNVLVLGLAIADFSAGVIAQPAFVSWNIYIFLSSDDKLETTQEIVLRVFHSISNVILLVSFLNIIAITADRFLAVYLHLRYQELVTTKRCGIALACIWVFCLAFNVATSSLMLVSYEGYIVFLTLYIALGVINIFLLVKISRVIRRHSVQIQAQQQSLQQSIDMPRYKKSVKTMTPSVQALSSSVLVLGLAVSDLLVDAVVQPLFCVVKYAELKFGKNADVSQTIGKVFHLMSYQLVSVSFLTLSAITADRFLAVHLHLRYQELVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5Q6</accession>
    <name>A0A6P8J5Q6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116308706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575044.1">
        <property type="nucleotide sequence ID" value="XM_031719184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5Q6"/>
    <dbReference type="GeneID" id="116308706"/>
    <dbReference type="KEGG" id="aten:116308706"/>
    <dbReference type="InParanoid" id="A0A6P8J5Q6"/>
    <dbReference type="OrthoDB" id="5988119at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031575044.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41598" checksum="B56AA8363322FB83" modified="2020-12-02" version="1">MEAKEQENSSLRTNNSRNVSEIITRAYVFAPVSNNVKLVISTAMLLFGVYGLIANSLILYFKHKQHRRRRCAIQRALTRSALKEYFINSLALSDLLCCLISLPLVTAEMFIDFVHNDWICKVNRFLNFIFPVITILNLLVIGIERYFAIFHPFKVLARHKAKKIVMGAWVLGVLLTLIPMPTYKLIYFEIEENSYTLICKYDNTLPLYRCLFIAFITICYIIPSIILIFVNLRILKFVRRKRCRVAPLQQVKTSKRTPSQTSRFKVTRMFMWLILAFIIPYLLFIVYNGLVMVLRPTISFTSDYLARYASAFFGFSNGAVSAAILFHNEKDLKRRLGDMLCNNCNQSQIYPDFPAESNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6G8</accession>
    <name>A0A6P8J6G8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116307386</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="function">
        <text evidence="16">Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Part of the nuclear pore complex (NPC). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96; this complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Does not interact with TPR. Interacts with ZNF106.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus</location>
            <location evidence="18">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573493.1">
        <property type="nucleotide sequence ID" value="XM_031717633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6G8"/>
    <dbReference type="FunCoup" id="A0A6P8J6G8">
        <property type="interactions" value="2643"/>
    </dbReference>
    <dbReference type="GeneID" id="116307386"/>
    <dbReference type="KEGG" id="aten:116307386"/>
    <dbReference type="InParanoid" id="A0A6P8J6G8"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.20:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.50:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12 18" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031573493.1"/>
        </source>
    </evidence>
    <sequence length="1040" mass="119296" checksum="2905AD03445B37A6" modified="2020-12-02" version="1">MAATSAEGPRSTLYSVSDEEKGETMDIGEGTSRRTMRSLDASRQSSEFYPRDSTLHYIWQYSEGTKEFDPDKMNKVVDTRREIRNKSEFEGNREIPDQNNEENIFKNSKRRSNIQKSLQLLDDAVGSPKPFLVTATPLLRTAGTPTPLLQRTPMTQLRHSTYTPSGMSSIADTDFDTEDLSMLSNDGYGRSTLTASLSRPTPTPGYSMGSISLMNETGLTSSVTPMKPLAGIADDLTTETQLDTTQVTNTSVLTDKDPIVSASSVLFQEFKDDLVKYPHSTHVFDLVAAYEKSCRNQVNQLNSIMRSTAPGKAIFVKKVEILMMLTQESYTWRLIGSLYSDRLQSGSYDDEAMLTDFMRKNWSEKKVISLLYDRESSTRQNQLVIDWLEKNAEDFLESVLHSDKVEYFSESICWENTLHELREGSKRHGSKRPLVTEMDPDAPVRQNRPLADLDVEDEERLLKHLFVFIRAGKLKEAQELCERCGQAWRAATLEGWKLLHDSNIDGVPDNGTLAEVEGNPYRDVWKACAWKMSNENKFGLYERAVYASFSGNLNQLIPACESWEDFLWAYYKVMIDVRVEQELHLNSRSDRQVENLPSAYWDQNLTPEKIFEELKSCSKESVRRQAEHHHHIIQTHIILDDIQGLLKIMNEWLQDENSPSNHMLRFMAHFVLFLRASGLETQEELSCPLLKAYVQNLIDDCQVPLVATYTATLPPELQIDTYAYFLEEIIDRKERQRCLELAESAGLDVQTITKTVVENIRGKDFKIDNDLSPALEAATTEEDRKKIEAVEWLVFDPSQRAEALKQGNAIMRCFIATRKHTAAREVFNKIPAGSIDVIYKQWQMRAGSSALPAEDDNAIREYLCIKAYLDAHDAFNDWFQHFHHGAPKKLSSETYSNFSEKVALEQRQKQYEVDRERWQNSLEIHSKATVERLYNVLLFPDGGWMFDQRMDGESDATRSQQLELLRQLCLPLICFLLHTVHHSTGQYKQCLQLADIIASEQYELYKVFRKDELQRFLTLLRETSLAVLENSMDPLGYQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7R4</accession>
    <name>A0A6P8J7R4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotrophin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031573135.1">
        <property type="nucleotide sequence ID" value="XM_031717275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J7R4"/>
    <dbReference type="GeneID" id="116307124"/>
    <dbReference type="KEGG" id="aten:116307124"/>
    <dbReference type="InParanoid" id="A0A6P8J7R4"/>
    <dbReference type="OrthoDB" id="5948321at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000812">
        <property type="term" value="P:regulation of barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF69">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573135.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13449" checksum="675ED24515496408" modified="2020-12-02" version="1">MADIINAIKANDVFELNRLLSQPGRYVNTPVGGGRPPLHIAVQRNRKNIAGILVSRGADVNLPDEDDCTPLMIAILNDNPNLVRWLIDMGAETDGKSPDGEPYCKVTENKYIIDLLRQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9Y3</accession>
    <name>A0A6P8J9Y3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Macrophage-expressed gene 1 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573630.1">
        <property type="nucleotide sequence ID" value="XM_031717770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J9Y3"/>
    <dbReference type="GeneID" id="116307500"/>
    <dbReference type="KEGG" id="aten:116307500"/>
    <dbReference type="InParanoid" id="A0A6P8J9Y3"/>
    <dbReference type="OrthoDB" id="5950457at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22579">
        <property type="entry name" value="MPEG1_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039707">
        <property type="entry name" value="MPEG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31463:SF1">
        <property type="entry name" value="MACROPHAGE-EXPRESSED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028455834" evidence="3">
        <location>
            <begin position="20"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="4">
        <location>
            <begin position="48"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573630.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="84596" checksum="6AF5706C8A728D20" modified="2020-12-02" version="1">MKTAVVISISIILLGLAAGKEDEAVQQCSKDVSASCPSPWKYTYPVGDPSYCLQGNNKGLLRMEVLPGTGWDNLRNLNMGMVVWKNYSQCLTSEDGKYLIPDNTYVVPLKESNVVLNSEFFDHWNNYSSMTSNSINAEAHASFFGIGLGGKFSKEYESVKKHQVEDKAVTTRVQLRYKFYTVKAQPDMQLHPDFKSRLLDIAANLQCNNTAMARYMADLLVRDYGTHYVTSIDAGAILAKIDHVKSTYAATFNSDKSKITASASASFFGSFGFSASYTHQTETKDLDTYLKNVAHSKIYTYGGPPYRANFSINQWEDGLPNNLVAIDRSGDPLHYTITPEALPELPEFLALDLSRFVLKSIKTYYKHNSIKGCTDASSPNFNFQAVLDDHSCKAPYTNFTFGGVFQNCSISGSPSTNPCGAFQQKNPKKNDYACPDGYNAVLLHQGLTPTTCHRECHGWWIFKSCHNDCGYARYNTYWCVATGSVKDHSGYLFGGLYTKIAMNPVTGTASCPPKLYPQRFGPEGMYVCISDDYELAAQYSLRFAGFFSCSAGNPLAFKKTTAPASGQVGLERALYSAGSSSWPKRCPTGYSQHLAIIDEDCEINYCVKANSLSAQGLPTIRRPPFRPLPKMNHNITIPLAIVNDDTGKVWFKDPNSLSWILATKSSVMKFMAETDINKGAIENLKASVDEIKPSTKSSSSSTGPKDDTMSPGTAVVITIAVIAFAAILILVVVVSVRRKTRRESNKSSMNPLLSSSTNYQTVGNVEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JD01</accession>
    <name>A0A6P8JD01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel protein Shal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116308177</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574420.1">
        <property type="nucleotide sequence ID" value="XM_031718560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JD01"/>
    <dbReference type="GeneID" id="116308177"/>
    <dbReference type="KEGG" id="aten:116308177"/>
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    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000081">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000152">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031574420.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="49601" checksum="276265CF6CE42C32" modified="2020-12-02" version="1">MERHRSVNNLDCWLPAARAGLVAMTPLMNKQFSGAIRQPLLNQNDRRIIINVSGRKFETWEKTLQKYPQTLLGSLDLDSFYDKEKKEYFFDRDPIFFRHVLNFYRKGKLHFSLDECGISYKDELKFFRISQDRMELCCFEEMDEASRRGVPKEPEKTGVAKCQCKPAKRSPKELIWDLFENPHSTLLGKTINITVGIAIVVSIMTTVVETVPCGNNLTCGQTYKRTFFNIDATCVFIFTLEYLVRLFVAPEKMKFIKNFHNIIDVASILPFYLRLFLQSSGGKSEQLVVLRVLRVLRVVKMARHSKRLRTLGGSIKNSSSELGFILFSFSLGVIIFATVIYYCEKDEPKTTFLSIPDSMWYAIVTMTTLGYGDMTPETTMGQLMGSICCVVGTLVIALPVPILEMKMKLIGQNNNPEDEDEDGEGPDNEHVCNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JFL0</accession>
    <name>A0A6P8JFL0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116308758</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575100.1">
        <property type="nucleotide sequence ID" value="XM_031719240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JFL0"/>
    <dbReference type="GeneID" id="116308758"/>
    <dbReference type="KEGG" id="aten:116308758"/>
    <dbReference type="InParanoid" id="A0A6P8JFL0"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027565577" evidence="2">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575100.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17522" checksum="8417D7F212E14DE4" modified="2020-12-02" version="1">MKTLMLLAALCLVLCVVLPQTDGACYLIRYTRCYLVQSNGRWYRICVVQYRYVCVRKRDQIEDDQGRTESKRKGPEKAILEKFPHKCSTYDKNGDGSITFDEFQKTLSDVHDTKTLQKLFKETDENGDGVITCKDEFLQAKFDFSKKPVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3F6</accession>
    <name>A0A6P8H3F6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287589</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550138.1">
        <property type="nucleotide sequence ID" value="XM_031694278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3F6"/>
    <dbReference type="GeneID" id="116287589"/>
    <dbReference type="KEGG" id="aten:116287589"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550138.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19526" checksum="05A77202C779D9F4" modified="2020-12-02" version="1">MSLQQRHKPKPKQKKRSTPVELMLIGKGMKKYGRDLKAVKSLYKASDSRHVQEASTVASTSKAVKTSAEQEFHSSESEFDIDSDSDWKATENDIFKKDTRYTNIQGSQSREEILSAVKNGDDAKDQADAKSKRKKSQRGKQTAKSKMSSILESLPALIQNANSAAKRQPKTIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H589</accession>
    <name>A0A6P8H589_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein 21-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031551534.1">
        <property type="nucleotide sequence ID" value="XM_031695674.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H589">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116288829"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="F-BOX ONLY PROTEIN 21"/>
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    </dbReference>
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        <property type="entry name" value="SI:DKEY-261L7.2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="1">
        <location>
            <begin position="479"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551534.1"/>
        </source>
    </evidence>
    <sequence length="591" mass="69526" checksum="A2E0B0D744B78976" modified="2020-12-02" version="1">MANMQTREESKEPSLLVLADELIDIILSYRFLDYRDLCRFAQVCIRFNHLACCSEIWKKKALTRWKRWRRPTDSHWKEVFKKRFKTETKIKEVLEKLGREFGPSSDVSERQYEELVHLENDDNYAGFLACSLEEYVFGDPRLTNLTHKHYAEKLYIYLRRNFLKKEWQNLMSKPIEEQHLEDGALIIAKWMEHKIDDSMTDYMKSSLDGLAERVRRIVGEEAEPLDFNQQXHPYYITDPNRCSEIINGIRKIIFEEDNFCGNMQDYYNVKNSFITEVLKTKQGIPISLAVVFIAVARRLRVKVEPVNAPRHFLIRWCSNPDSRTNRYTYIDCFDGGKIYSEEQGMQQFLSGLLYPFETSEDALALASPKDIFIRMATNILNIYQSASRVDSGLQYLCDALKLLILIKPDDRRNAVMLARIHLHLGINLDQCIEILEGQSLLDRAAIRSLESAREQIERQERLRNQPVVPKLRSDPKNKEVAFKVGMVMRHRRYHYGCVIYGWDPFCDMSEPWILQMGVDRLPNGRNQPFYNVLGDDGSLRYAAQENLEEEPNQAFNPHGNLGRYFEHWTGTKYLPNYYLRQEYPEDVDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5P0</accession>
    <name>A0A6P8H5P0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THAP domain-containing protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551689.1">
        <property type="nucleotide sequence ID" value="XM_031695829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5P0"/>
    <dbReference type="FunCoup" id="A0A6P8H5P0">
        <property type="interactions" value="965"/>
    </dbReference>
    <dbReference type="GeneID" id="116288964"/>
    <dbReference type="KEGG" id="aten:116288964"/>
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    <dbReference type="OrthoDB" id="5971057at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551689.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16562" checksum="5E9CE7F71874F096" modified="2020-12-02" version="1">MGKYNCCVPNCTNNWRNSPGLKFHALPGDPKVPREYKRLIRNDNLRVSSTSTKNCCKHFPGGERCSRTQLPSIFTWSKAIHKRREIVKNEVPKKSNTPGSSTSTVIESTVTSINMDDQHIFEERKCLPHIFVLVEDTLRLSFLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H662</accession>
    <name>A0A6P8H662_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione hydrolase 1 proenzyme-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">LOC116288343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550971.1">
        <property type="nucleotide sequence ID" value="XM_031695111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H662"/>
    <dbReference type="GeneID" id="116288343"/>
    <dbReference type="KEGG" id="aten:116288343"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF54">
        <property type="entry name" value="GLUTATHIONE HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="434"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="485"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550971.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="66503" checksum="3DA94F0A32D20885" modified="2020-12-02" version="1">MTLGSQESLQDETPDTENLIIHEENTGNTTNQKKKSKWNRLKGIRVIIVSCIVFAIAVTVALIVDIYIGDHHTGHAAIATDVQKCSDIGLELMKKGGSAVDAAVGALICVGVMNPESSGLGGGGFMLIAAPHHSGEVIDFREVAPQSATVDMFNKSANMAQQGGLSVAVPGELRGMELAHKKYGKLKWSELIEPSIKLARDGYTLSNHTAKVLGIPHVQRKIKKSKQMMDMLMPNGEYLKEGDIIRNPKLADTLAIIAKEGAKALYEGKIAESIVKAVKERNGILSLADLKKYTAILKPGLNSTYQGYQILTVPLPASGPVLISALNILERFNLTKKDQGKNTTYQYLIEAFKFAYAQRTHLGDPSDPHNADVLKFVDKMTSKKNAETIYRKIFANKTFPPSYYSPASDEVKDNGTVHVSVVGPDGEIVSVTSSVNGYFGSYVMTDTGIILNNDMDDFSSPGIDNQFGIPPSKANFIRPGKRPQSSTVPVIVRHKQDPCAFRLAVGGSGGSHIPSAVIQTLINILSFDDTLKDAVERPRVHHQLIPNEVEAEGDKFKSWNQEGVLEYLKQVGHVVNTLDKSRSDVNVAQNYHNILRAHSDSRRGGSGSAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6A1</accession>
    <name>A0A6P8H6A1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551919.1">
        <property type="nucleotide sequence ID" value="XM_031696059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6A1"/>
    <dbReference type="GeneID" id="116289179"/>
    <dbReference type="KEGG" id="aten:116289179"/>
    <dbReference type="InParanoid" id="A0A6P8H6A1"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551919.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18840" checksum="2D9A4EB4E9E4F280" modified="2020-12-02" version="1">MANEQKERSSRVVVAIDGSEHSQRAFDWYCENAHKDGDSVMLIHANDISDRQIQLHPYGLATVESWDKWIERCTEDSKKLLSTFEEKCKKLKYNCKLFTQIGNPPEVICKFAEEKDADHLIMGCRGQGSIRRTLMGSVSDYCVQHSHAPVTVVPPANREHHGFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA36</accession>
    <name>A0A6P8HA36_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289623</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031552431.1">
        <property type="nucleotide sequence ID" value="XM_031696571.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289623"/>
    <dbReference type="KEGG" id="aten:116289623"/>
    <dbReference type="InParanoid" id="A0A6P8HA36"/>
    <dbReference type="OrthoDB" id="5987860at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF7">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552431.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32786" checksum="CDA04D7BC22C976B" modified="2020-12-02" version="1">MSYYTNKIILTINWSKQESSTAASREVPMTKLFNDKIEEMGHEIAEICHDNVAAIENWATKEKRILNSYDTWHGGKNVKKMMKKITXGTKKEEGSTWFSELTDKAKATKTHCYFTMKAFSTQNKTTAEFXSALLNVVDHYQGKHSKCPTESRCQMADYVCSKKPLKNPKAIEAYXKXLTKTLIYRNPEAYMRCRDTYWIESFHSILLIYAPKRINFGDNTYTTRIQLAVLDWNENVNREVSSVINYQYARNPDRKAPTRVRRPKTFCFRDAIWHVFFSACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA99</accession>
    <name>A0A6P8HA99_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116287118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031549612.1">
        <property type="nucleotide sequence ID" value="XM_031693752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HA99"/>
    <dbReference type="FunCoup" id="A0A6P8HA99">
        <property type="interactions" value="2107"/>
    </dbReference>
    <dbReference type="GeneID" id="116287118"/>
    <dbReference type="KEGG" id="aten:116287118"/>
    <dbReference type="InParanoid" id="A0A6P8HA99"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031549612.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50878" checksum="0845CE35F6565036" modified="2020-12-02" version="1">MAAASTCVRRLPLVVILGCTGTGKSKLAIEIGKKIGGEIISADSMQVYSGLPIITNQVTKEELQQCPHHVINFVSPFKEFSVVQFRNLALPLIDDIKKRGKIPIIVGGTNYYIESLLWDILIDAENEKESETLSSGEENESFSIKRRKVIECNGGLESTGSIPGEEKPSLHTKLATIDPEMASRLHPNDTRKIARSLQVYEHHGIPHSQLLVDQRTKEGGTAFGGPLRFDFTCVFWLQCEKEVLNDRLDKRVDKMIENGLVKELLDFHQAYNKERIDNVGAKYTEGIFQSIGFKEFHEFLLKPNLNEIENIDMLVNEHKEIFENCVDSMKTITRRYAKKQTQWVKNRFLSRPKGAAPDVYGLDATDLELWNQSVLERAILILDAIINDEIPNVKPLERNITDPNGAHTKHVCGVCDDRVIIGDKTWEKHLASKSHKWHVKKIRKMENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAD1</accession>
    <name>A0A6P8HAD1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sacsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552113.1">
        <property type="nucleotide sequence ID" value="XM_031696253.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HAD1">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="GeneID" id="116289360"/>
    <dbReference type="KEGG" id="aten:116289360"/>
    <dbReference type="InParanoid" id="A0A6P8HAD1"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052972">
        <property type="entry name" value="Sacsin_chaperone_reg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600:SF42">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4352"/>
            <end position="4463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4314"/>
            <end position="4346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4320"/>
            <end position="4334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552113.1"/>
        </source>
    </evidence>
    <sequence length="4473" mass="509610" checksum="4377A290D2A64D26" modified="2020-12-02" version="1">[encoded data, 4473 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC91</accession>
    <name>A0A6P8HC91_ACTTE</name>
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        <submittedName>
            <fullName evidence="15">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116287751</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550292.1">
        <property type="nucleotide sequence ID" value="XM_031694432.1"/>
    </dbReference>
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        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="GeneID" id="116287751"/>
    <dbReference type="KEGG" id="aten:116287751"/>
    <dbReference type="InParanoid" id="A0A6P8HC91"/>
    <dbReference type="OrthoDB" id="2015116at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
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    </dbReference>
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        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
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        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
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    <dbReference type="InterPro" id="IPR001507">
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        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF40">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
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        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZP_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1281"/>
            <end position="1300"/>
        </location>
    </feature>
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        <location>
            <begin position="184"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
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    </feature>
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    </feature>
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    </feature>
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            <begin position="781"/>
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    </feature>
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            <begin position="819"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="859"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="896"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="934"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="13">
        <location>
            <begin position="982"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1260"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="430"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="547"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
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    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="807"/>
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        </location>
    </feature>
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        <location>
            <begin position="848"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="923"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50287"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51034"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550292.1"/>
        </source>
    </evidence>
    <sequence length="1344" mass="149338" checksum="7C2CEE9A4E2DB72E" modified="2020-12-02" version="1">MYCSNFNAEEDWSEGNNTFTYVGSXRDDWWNVRITDRGNWIGKITHSNSYNYMQLEARVNRTVGGVFNNSSPVSSLPLTVYVVQGIPSIIRIPVEDPDGDIVRCRYASYQECYRGMCTYFPHGVLDEGNCSLSYNGGGYVNQLFPVILKLEDFPSGTTQFDSSNSLGSVDLQFVVHVVTLTDTVRIQGGGSSGRLQVLHNGVWGTVCHDRWSMANTHVVCRQLGFAGALSYHNSGGGTGQIWLDEVRCSGNESAIQQCRHGGWGSHDCSHGEDVIVSCYHTECRYYTVLNTTDRAASYSGITNKCDRYDIIPGWYRFMGDAGTAIAKSCVDMNHCGTYVPGWMRGSHPTQAEGIVTRMVCYHWNSNCCKLSNSIRVRNCVGFYVYELGRPPSCNYRYCGSGNSTKNTCASSPCRNKGTCIITVNGHRCYCPSGYSGTQCETNMYPCNSGPCHNDGTCSNGYNGRYYCSCPNGYNGSQCEIGEVRIQGGGSAGRLQVRHNGVWGTVCDDGWSMTNTHVVCRQLGFDDALSYHNSGGGTGQIWLDDVRCSGSESAIQLCRHGGWGSHNCGHGEDVFVTCYPTACRNYTMLNTTDRAASYRGSTYYCDRYDITPGWYRFMGDAGTAIATSCVDKYHCGTYSPGWMNGSHPTQAEGIVTRTVCYHYSSNCCNLNNNIRVINCKGFYVYELGRPPSCNYRYCGSGNSTNNICASSPCRNKGTCATTYYGYRCYCPYGYSGTQCETNMFPCNSGPCRNGGTCHNYYWLNRGYHCSCPRGYTGQQCQTHMPCTSNPCRNGGTCQGGVGWYRCSCPYGYTGQQCQTYMYPCNSRPCRNGGTCHNNYWYNGGYYCSCPRGYTGQQCQTYMPCTSNPCRNGGTCQGGVGWYRCSCPSGYTGQQCQTHMACTSNPCRNGGTCRNGYYGGYYCSCPSGYTGQQCQTNMPCNSDPCRNGGTCRNGYYWYNGGYYCSCPSGYTGQQCQTYLKTSVTCGENFMQIDLRDQYFPGLNWRSLHLKNTSCTATKTAYTMRLRAPLDGCGVTYVEHDKKITFWNEVRNEQSVWPSWGGNLSAITRGENLLIPFYCEYXREKIVSTSFSPSRKLVYASEGSYGNFTFTMDLYQTSRYSTPYSPFAYPVVVYPNQPLWVQYEVKNTNADLVVFAENCRATTSTNPDSFPQHVFLERGCTRDPTMVYWYNPYSNVQRFSIRSFSFVYSNSFLVYLHCELIVCHRNSTNSRCAQGCISSRRRREAVDGSNIHDLSVGPLKGSDAQTGTDEQGGEETSSANTATIGSVSVVGAVALLVAILLSVKMFHNRRNXVPPXETPPPAIVMNQTVNSYEQHVMEDGERTEIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDI1</accession>
    <name>A0A6P8HDI1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium channel subfamily K member 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116290250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553118.1">
        <property type="nucleotide sequence ID" value="XM_031697258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDI1"/>
    <dbReference type="GeneID" id="116290250"/>
    <dbReference type="KEGG" id="aten:116290250"/>
    <dbReference type="InParanoid" id="A0A6P8HDI1"/>
    <dbReference type="OrthoDB" id="5970010at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="94"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031553118.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34343" checksum="C581CF268270775A" modified="2020-12-02" version="1">MSCQNLNVVTKNFLIRLAIYILYSILGALVFMSIENNAIEEELKNLEKTRIQARNSLAEMQNSTHFFNMTVDQMVAFARRVVQVENELSATPTKWTYDQGYRLTFEIMTTIGYGSTPPKTQTGRLLCVFYTLVGIPIFLYFMKSIGEVLNRGMTSLVRHLEKKVLKRNEDKNVELKVLIGFIIALILDVSLEIIVVAQDKKRDFTVIDAFYCVIITATTVGFGDLTLENELTMIISLSLLSTVLDGVLCYMEKTIEEQINETKGCQCFGLNKNENRNTTEDAEAYGADNKAVTVEDLSRDEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDQ3</accession>
    <name>A0A6P8HDQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">D(2) dopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116288164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550772.1">
        <property type="nucleotide sequence ID" value="XM_031694912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDQ3"/>
    <dbReference type="FunCoup" id="A0A6P8HDQ3">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="GeneID" id="116288164"/>
    <dbReference type="KEGG" id="aten:116288164"/>
    <dbReference type="InParanoid" id="A0A6P8HDQ3"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550772.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40517" checksum="EDD9109F856A60F4" modified="2020-12-02" version="1">MSNFTSNTRAESECLLPLEHGIILIILNIISSVFGSIGNLLVCATIYTTTGLQTISNYFLVSMAVADLIVTVVAQPLLVGFLGAAIDGSCANIVELLFRLAANISCAVSVIHLCFISVDRCLMVTKPHNFSRIMTKMRSRILLLISWVLPIIYAVLRLKVSKRATSLFTVAMMAVCYMVIVISYTLIIIQVRKQQNLMQSRQTAYSAGNSKRKRDQMERRVAMTIGIVIIVFTISWLPILVLRSLNADKNSGTAYNWARTLALCNSAMNPWIYCYRIPEFRAAYRRLFILCRWGQVKGSGLGEAETTMTSESATRNQDVHSFEHDNVPVDAGSGKNQHSSMKIVSVQPECEQSQGLGGDSATPGSAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF57</accession>
    <name>A0A6P8HF57_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DBH-like monooxygenase protein 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554371.1">
        <property type="nucleotide sequence ID" value="XM_031698511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HF57"/>
    <dbReference type="GeneID" id="116291339"/>
    <dbReference type="KEGG" id="aten:116291339"/>
    <dbReference type="InParanoid" id="A0A6P8HF57"/>
    <dbReference type="OrthoDB" id="10003276at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027670448" evidence="2">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="38"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554371.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25084" checksum="76A7CA06289B386A" modified="2020-12-02" version="1">MFAILGTLVVVFAFSVPSQAALSDEYQNEERLSAINESDCMLYWTYDKTDSTISFAAKARTSGWVGLGFTSKIDNTTTYDVVRGSDDDLTKKKEIYDFHAVGKQTPVNDTQQNLIEKSVAENNYYTTIKFKRALDTKDSNDTVIKPGPMIVVWSYGNIEELESTYKEMGYKTVTLIPEEQKNDTTSSTATPETTNGPVSKAVVRQDSWQLLALSAILFIVPALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFD2</accession>
    <name>A0A6P8HFD2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116288622</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Deltex family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031551302.1">
        <property type="nucleotide sequence ID" value="XM_031695442.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116288622"/>
    <dbReference type="InParanoid" id="A0A6P8HFD2"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Macro" evidence="13">
        <location>
            <begin position="917"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1308"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1389"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="584"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="876"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1133"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1462"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="215"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="646"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="883"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1252"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="15">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="15">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031551302.1"/>
        </source>
    </evidence>
    <sequence length="1642" mass="184229" checksum="97AC52B49A513A5C" modified="2020-12-02" version="1">MEVEGIDPELDPLTEEGRVDINDDEYESLLPEADKPGFFDKLKRKFGESRARGALNSLADMFKRKNPGKSLPSYMQMKDLEPVPEAPGAQWLSKIQEQMDESMEKEQPDDFDRLMDLFPDWEPSNAIMVFDGSNEWGKEVILGRLPRSGSKIYVIRDERGRFSAYPDIPKTLDRAIGKPNLAVQEQMTEDQVSARKQRFFAALSKLPPEAGGKTEDQKVMQLQAAKEEIESLSAEVEKQNWEIENLEQEKIASIASLKREKDAEIKRLVDKIKNITSGREEAEELQAVKEELQVAKEEKAALEKRYEGAMKELGEAKADRSGTFQALQDAIAGLDEKDEELMNSANALMEVERRRMQLSNEIARKDEQIRQLSGAVEDLEHHANVQREIIADQTRPEEERAAAERELETTLERLEEAKTKLATAERERGLTTKEKVKRALVKYGVPLAFAVGIAGAVAAIMNALKATGAGVKGLVAQSVQKKEQKFDGVLLTLEQYKAHVQNKEMENAQVFSKVSAMIDPTKLSLTMQETQVLLKEIRDKTKVDIAQPQNKSYVFILTGSFQQXQESYSLLRNRLFKSAVCNGNDSKHGEKASIGKNIPKRLQNGTECHMNGEEELELPSMKGEAKTASKKVNDRATTTSSQFSKTSKESSTSKKEGSSHDSNQKKTEKIFLTENTMSSKPSVQYPSPSGTKIFPNGEISGPKDIDSLLSGGKDNSEILCSPLTRKSSVSSKDVTVDNTHKIEISSKVWNVFVKIHEKQLQSITSNFSVQIEPEDNHSXAIIKPSGECTTXKLKIATEKLKGLYEEARSKMKLVRFVLADPXNKEXXSNLRKTVLQVXKDFPVFLERAEDRQSWEIFGEDSQVEKGMKLLEENVKLERKEQNVDDETMEEAXSXDESDNADDQXSDTESTDSDDDILDEKLEHHLEMVKVSVYRGDITEEKCDVIVNAANEKLEHGGGVASAIAFKGGSSIQDECDRIXNAKGKLNVGDAVISPSGFLRCKMIIHAVGPNWNIDKGEKGKALLKKACKESLIQAEXYRFKSIAFPAISSGIFGMPKHICAQVMFDAVEEYSKSVPSTGEYGLRDIRFVNNDVKTVKVFRSEFKARYGNGKVIENKRDSIESGDLPYLVGHPSIGXDNSSNISRPWNGSNETTIKTKSINTEFTKHSKXISSSESHSRSQENGLSLLPRGGRPLKEDSSQSLIDNKGKARHQKKTRCERPVREDSGQPLPNKMEENLLQNQPRRGKSLPVKSKGVEPRNHSDSGKHGVVKSDFFGGGARPKQSQSQHTEHLLAYSSVIKTKQEDDVPKCSICLNEMKQPKTLPRCKHTFCKTCLETALQQSPKCPYCREPVTDKQSNPTRGHGTNGYRNDDFPFSGLDNYDDHXDDATLCLVCAKPVRQAQILSCRHTYCKPCLDRAFREYPACPCCSELERNQPSTHSWKQDPYNKLYSYHQGWMDMDSLRQFPPDFRRERPRSNRGNRPSDAQNXDGYQEQFGFPDASXRRGQPGRGAQPDGSMRDRREMFSLPGYXDYDTIVIQYSFNSGXQGPNHPNPGVRYEGTSRSAYLPDCHEGRKVLQLLKKAFDAGLLFKIGRSMTSKLDNQIIWADIPHKTSTSGGPXKYGYPDPAYLSDXKQQLQAALKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGH8</accession>
    <name>A0A6P8HGH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Protein sidekick-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116291857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554931.1">
        <property type="nucleotide sequence ID" value="XM_031699071.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554934.1">
        <property type="nucleotide sequence ID" value="XM_031699074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291857"/>
    <dbReference type="KEGG" id="aten:116291857"/>
    <dbReference type="OrthoDB" id="6418794at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653044" evidence="4">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="120"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031554931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554934.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="39947" checksum="2E7AB9DA24955A22" modified="2020-12-02" version="1">MTLMKLVVILASLFALLNIASGSIPSAPINVTIDNIGSRSINISWTRPAEDGNNSQLAYAVFYKVKGSSVLQLVELEIVTKAKLLVKPYREYEIFVMAKNKDGYGPPSVIKSILTAEEEPETCPTMGYIELTDDDLDVIWYPIPKEDQNGKITHYVIFYKXKSMPEFKNVTTVNITNHDPNGILHKLKNMSYAESYGFKVAAVNSKGMCKGWQSMXLYHKYASATTVSPCAAATTASPSTVPTPSTPTPPLPTTTDDLSTTPLLKTTTSEPKEPSIPISTNQPTEFPSPADKLARTSESNWLVYVLIAMAVIVAIMGVTIFLLIWQLYKNHRFYRLRQEQYRMSNATPNVGIDNKAQDNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH99</accession>
    <name>A0A6P8HH99_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555779.1">
        <property type="nucleotide sequence ID" value="XM_031699919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HH99"/>
    <dbReference type="GeneID" id="116292576"/>
    <dbReference type="KEGG" id="aten:116292576"/>
    <dbReference type="InParanoid" id="A0A6P8HH99"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="107"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="248"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="358"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="466"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="606"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="757"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="867"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555779.1"/>
        </source>
    </evidence>
    <sequence length="971" mass="106727" checksum="C32A8817DA616826" modified="2020-12-02" version="1">VRLVDGKTPKQGRVEVRYKGTWGTICNDEWGIWDAYVVCHMLNYSKAVTGTTASVKGNGPIWLKRLYCTGSQESIDQCYHAGWGNTDGCHHSRDAGVVCGNAINVNVRLVDGKTTNGGRVEVRYKGTWGTICNERWGILDAYVVCHMLNYSKAVTATTASVKGTGQIWLKRLYCWGSEESIDQCLHAGWGNTGGCDHSHDAGVVCGNLTPEEKAIKVRLVGDQKYTGKVEILYQGTWGVVQAKDLLSVRLVDGKTPKQGRVQVRYKGTWGTICNDEWGIYDAYVVCHILNYSKAVTATTSSVKGTGPIWLIGLRCLGSEESIDQCRHGGWGNTGGCDHSRDAGVVCGNLTPEEKAIKVRLVGDQNHTGKVEIQYQGTWGVVCDTSWDIRDAQVICRMLGYKAAENAIRYIEGETPRRILMYDVGCRGREKSIADCAHSGWWKYSCSNNLLAGVVCQTNEDPPPVQVCLAGGRSVNSGRLEVRYHGQWGTVCDDGWDMKDAEVVCRMLGYSGVQEYITTKFTLVKGIIWLKYVDCTGRETSIADCSRGEWGNVYCYHDEDVGVTCIVGKALYFSRLEGGGWWKYYCSNKQLAGVVCQTNEDPPPVQVRLAGGRSVNSGRLEVRYHGQWGTVCDDGWDMKDAEVVCGMLGCVRLVDGKTPNEGHVEERYKGTWGTICNDIQWDISDAYVVCHMLNYSKAVTATTASVKGTGPIWLTGLDCGGSQKSIDQCPQVGWGNTDGCDHSRDAGVVCGNAINVNVRLVDGKTPNEGSVEVRYKGTWGTICNEDWNIWDAYVVCHKLNYSKAVTATTASVKGTGSIWLKGLRCLGYEETVDKCRHAGWGNTGGCDHSRDAGVVCGNLTPEEKAIKVRLVGDQNYTGKVEIKYQGTWGVVCDISWDIRDAHVICRMLGYKAAKHAIRFIEGETPRRMLMSYVGCSGREKSIAECYHPGWWVVPSYCSNKVLAGVVCGLSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHK2</accession>
    <name>A0A6P8HHK2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116289341</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116289341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552092.1">
        <property type="nucleotide sequence ID" value="XM_031696232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHK2"/>
    <dbReference type="GeneID" id="116289341"/>
    <dbReference type="KEGG" id="aten:116289341"/>
    <dbReference type="InParanoid" id="A0A6P8HHK2"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027605742" evidence="3">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031552092.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="34680" checksum="B2F487E28AF69113" modified="2020-12-02" version="1">MAAKLLLFVPLLSFIFKPGQSLQSKFDKKGEVRFGNFLNISDGQILEINGSVINKMTVKDKNQCLVECVNGKECLSINLYSDQPNQVQCELLNWAGTAFHSLLKPKANSQSMMLATACSPNPCQNGGDCIAYSGGHQYNCSCIIPFTGDNCEKAEGCVLFDFENGLPGWTRTGTAFNNQPTYGDNSLVRKPAEPAKQRGDWYIGTFENRTSPSHPAGGIQDDFPTGTMTSPKFTIRGRSLKFLIGGGSDVNKERVELLIGGAVVAKAASQTNVETMKLHAFDVTSYRGQVAQLRLVDDGSSGWEHINVDHFEDSICSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIH7</accession>
    <name>A0A6P8HIH7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AH receptor-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116289645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <property type="nucleotide sequence ID" value="XM_031696592.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
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        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
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    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="7">
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            <end position="157"/>
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            <dbReference type="Pfam" id="PF23322"/>
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        <source>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552452.1"/>
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    <sequence length="336" mass="38959" checksum="1A9801B514320329" modified="2020-12-02" version="1">MADQTSVAPKVSKEIIYPGEGDIPRYENGSKATFHFKVYKKTTKGRKLLDCSKTLGQPFELLIGKKFKLEIWEEMIKTMRINEVARFTCDKEIVRGYHFVSKNFRNAVKQSKGEHSKDHDHHHHEHSCSLSAVNPTGYADLDKLARKPRDLIFEMELMSVDNPGQYEKETWQMDPSEKLSVIPKLKQEGNELYAKKEYEAAADKYAKALGLLEQLSLREKPGDDEWVQLDKMKIPLLLNYSQCKLLLGDYYEVIRHTSTVLEKDNDNVKAIYRRAKAHKACWNPDEAKNDFKRAAELDESLKKAVKKELDELEQMIKEQNNDDKDKLKKLFSSRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIX4</accession>
    <name>A0A6P8HIX4_ACTTE</name>
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        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC116292596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116292596</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="nucleotide sequence ID" value="XM_031699941.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="semaphorin-5A isoform X1"/>
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    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028296499" evidence="9">
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            <begin position="24"/>
            <end position="1157"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="854"/>
            <end position="873"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="885"/>
            <end position="904"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="910"/>
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        <location>
            <begin position="952"/>
            <end position="972"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1016"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1037"/>
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        <location>
            <begin position="1060"/>
            <end position="1079"/>
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    </feature>
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        <location>
            <begin position="411"/>
            <end position="520"/>
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            <begin position="577"/>
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            <begin position="668"/>
            <end position="844"/>
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            <begin position="847"/>
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            <begin position="1101"/>
            <end position="1157"/>
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        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="103"/>
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        <location>
            <begin position="104"/>
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        </location>
    </feature>
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            <begin position="124"/>
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        <location>
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            <begin position="207"/>
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            <begin position="577"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031555801.1"/>
        </source>
    </evidence>
    <sequence length="1157" mass="126374" checksum="D8C0F47DC2BF9797" modified="2020-12-02" version="1">MENFIIVILKISIFCFLSTAVSANSSNSVVITPSPSAVNGSMQSTTPIAEATGNMSSTIAVNQTYVAPQPTASPGGQPGQGQGQGQGGQGGQSTQSNTAGQSASVSPNSTASVVLQETPSAGGQSAGGQSAGGQSAGGQSASVSPSSTASVVLQETPSAGGQSAGGQSDGGQSAGGQSGQSNTTGQPASVSPSSTASVVLQETPSAGGQSSGQSSSGGQSSSGVQISNQLSAYLKTLSPEQKKVVEEFDTKRKQDMQKLEITSEVKPLTSESADSSFIPKFGSLLEDSQRFGQDFDNQFNAKLDYTVNTNSTVLQTKKIDCVSQRVNRFPVNPQSTGLAANFISLPLQCPMIVKQAPASRRRRDVDYSVELKWDYHPKEDPVEYVHMYRYIRARREAAEQQNNSCSQSPCLDTRLSMTLKITSRNYTTELNDKASNQYKTLTENIKNLLSNNITATNSNWVINIHGFELSSGSIGVSFFVDCPTTYWSNIKDQLQLIVSVASFGNYSINPSFSIVQKVTVVDGAWSKWSAWPDSPNSFEECGDNFRVRRDRSCTNPSPENGGKKCEGPSVEYKKCNCSRTFENTGGTISSPYWSSKNYPFDTECVWILKAPFNHSVVLNFDEFNLESDKKCFYDYVQVFDGSNSSAPELMPRTCGTKGFNRTLKSSDTIMMIKFRSDKTVNDKGFKATWTKMVQPWKPPKPIEYEEQNVTVTNLISCPTYNNSFIPLGKATTCLDKSSGGDCYFENPAYLISCVIGVKMSRNLPLTESSAINATFRHIMHKDLFPGFYTEDKFCVTWNQSLSKLPKEAWTRKGCSVYSTNLTHTTCKCDHTGIFAVLASEKVVYKKLTLLANTYSGIGISFFLILLAIFHIVWKVNIHGGEVMRMNICVAIIVMMTAFLIGANVEAEKTLCGFLTFLLLFSVFAQFLWLMLHGLRIHGKIKEVFASGFNIEIVYVVFGWGLPLVLSLIAIGIQVEIKNEKDVCWTAVAGGSMWGYSAPLLVIILLNISVLIAILIPTTERKTKYDYREMKYRVIKDGVLLVLFGVTCLTAYLTVANETFAPQYFLTISIILQAVAMIVFGREGRKDFVKLKKKKVDMADSLSQNTNEEDFPERFDEESMSDRRSSKKSGKSGINSPGVDARTKSLRSGKQQETDIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL47</accession>
    <name>A0A6P8HL47_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pyroglutamylated RF-amide peptide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557119.1">
        <property type="nucleotide sequence ID" value="XM_031701259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293783"/>
    <dbReference type="KEGG" id="aten:116293783"/>
    <dbReference type="InParanoid" id="A0A6P8HL47"/>
    <dbReference type="OrthoDB" id="9944627at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="38"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557119.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41952" checksum="49C7BD34B65622FE" modified="2020-12-02" version="1">METGNLNSSCGFADSFSSNEVLIQVTVLGVILALALVGNVLLIYVVLKNKCLRKSNCNDVFLLNLGISDMIIPLVILPREIAVYYNQEDSWPFDLVWGGFTCKVYTFLXNLSPSVTVLTLISMTIDRFFAIVYPTKIKLISNKIRKSMMXSTWVIGSATSSTYLFTMSIKKDSQGNKECILEWPRRGSLAIEDSNNIFMIFNLLFYFLIPLFLMIILYSLILSKLKTKCHVHSSQMARKRMGVARRVTLMTVCVIGIFLVFFGPYYVLMAFLAFYWKWNYPPLCSWPTIILTVRFLVLSHAGVNSFICVFLIESNRRKVATALMKAARVMTSSHLGMKNILGSANSCSLRNMTENRSASNIRIDGSRIIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMM1</accession>
    <name>A0A6P8HMM1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557604.1">
        <property type="nucleotide sequence ID" value="XM_031701744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMM1"/>
    <dbReference type="GeneID" id="116294194"/>
    <dbReference type="KEGG" id="aten:116294194"/>
    <dbReference type="InParanoid" id="A0A6P8HMM1"/>
    <dbReference type="OrthoDB" id="5970227at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557604.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33420" checksum="035EBEF8CC3D5965" modified="2020-12-02" version="1">MASIKYNDEELNYFRVCKVTTHIIPDGLRKVFKQEWNTRYQATHGQWQDTSKNGMDFYGMESPKNKKIKPRELSIMKNGNTNEWDCTCLFYGILYSNSIKPTLNVKKSVDELRKFRNEVFAHTKDGKLKEADFKTSIDKVITSFTDLKLDTTEIEEIKNETSFPTEELEDIKKQLEKKKKRNEEPRPFCVLPAKPSHETVSRLNEVDQINEEMERLRNAKNNEVTVVYLSGNPGCGKSEVARQIGERFFDEKSTEMNFVMTVNASTIDTLLQSYVEFADRVKCDKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNF6</accession>
    <name>A0A6P8HNF6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Src substrate cortactin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031557216.1">
        <property type="nucleotide sequence ID" value="XM_031701356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNF6"/>
    <dbReference type="FunCoup" id="A0A6P8HNF6">
        <property type="interactions" value="1559"/>
    </dbReference>
    <dbReference type="GeneID" id="116293864"/>
    <dbReference type="KEGG" id="aten:116293864"/>
    <dbReference type="InParanoid" id="A0A6P8HNF6"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000398">
        <property type="entry name" value="Hematopoietic cell-specific Lyn substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003134">
        <property type="entry name" value="Hs1_Cortactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF23">
        <property type="entry name" value="CORTACTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02218">
        <property type="entry name" value="HS1_rep"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51090">
        <property type="entry name" value="CORTACTIN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="476"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557216.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="60348" checksum="5A5EC5BF33FE2EBB" modified="2020-12-02" version="1">MWKAQAGINVPLGGDNAEDDDWETDPDFVNDVSEEEQRWGAKTIEGSGHQESLNIKDLRQQVEKDHKNVKKEEMESGPKSSYGYGGKFGVEKDRQDKSTVGYDYEAKLSKHNSQKDYATGFGGKYGVQKDRVDKSAVGYDYEGKTKAHDSTKDYSKGFGGKFGVQKDHQDKSAAGWDYEGKTEAHESTKDHSKGFGGKYGVQKDRVDKSAEGFEYQGKTEAHESTKDFSKGFGGKYGVQKDRVDKSAVGWEYEGKTEAHDSTKDFSKGFGGKFGVQKDRVDKSAVGWEYEGKTDAHESQKDYAKGFGGKYGVQKDRMDKSAGGYEDMQEVKSEYHTAKPRTDSGSAGNLRARFENMAKQEEEEARRKAEEEKERRRAKEEREKEASKKRQEREAAREKEENEEEERRREEEEAQREADEAEREAEEARRREAEEAERQEQERRYAEEDAEALYDTASPAKPENQEDEPQAEVSSGDYGVVATALYDYEATGEDEITFDPGDIITNIEVIDEGWWSGTCNGQSGLFPANYVEVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNS3</accession>
    <name>A0A6P8HNS3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metalloproteinase inhibitor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554272.1">
        <property type="nucleotide sequence ID" value="XM_031698412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNS3"/>
    <dbReference type="GeneID" id="116291261"/>
    <dbReference type="KEGG" id="aten:116291261"/>
    <dbReference type="InParanoid" id="A0A6P8HNS3"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027465">
        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="4 13" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="5 13" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027702051" evidence="10">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="11">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554272.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32302" checksum="011DE840DFEFB303" modified="2020-12-02" version="1">MMQWIILALSLVIIGMANGLCMPEHVQTQFCNADYVVRVRVMSAVKHEVPELPPRPTPLVTTQNRTTDSNEDKIKEKTTQGVAPWRRGKQAPAPFRFVRSIVSNRRSYRQYPFLGWRYQEIKIKRILKGVGLVENTQKTHAQLRTNKTTRYSSRMYVSPWLQLKPGKAYILAGKVISNRLYLSRCNWYSAWDKLSAGQIRDLKKTFVQGCKCRVQFCYKPGCEKTKAKGVCMWRPQGFYPVDDCRYHHSLCRVHNGNCQWVDNEGFQKCMKNYTALIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQT5</accession>
    <name>A0A6P8HQT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294458</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557911.1">
        <property type="nucleotide sequence ID" value="XM_031702051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294458"/>
    <dbReference type="KEGG" id="aten:116294458"/>
    <dbReference type="InParanoid" id="A0A6P8HQT5"/>
    <dbReference type="OrthoDB" id="5974738at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557911.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="70029" checksum="E92BBC5228EFB49B" modified="2020-12-02" version="1">MFWKMDGMRLEDILPVPKKQPGRHFSGGYHMLGKTXSSYDDKYAQMTYGDHYRKKIEGEIERERNRLDEVMMEPKRQATQQKRSIKIAQNTVKRYDLNELRHHQRRCAALLFGARQQGNHEVPYLVRWAPRRRESYYLMSERVYNDRLLMKLREQEEEERRRMLASPMNFDFDDNFGNTRQLYEFQKLVSQTSRQIKGLSFDTEYKDYKFDFKXEEKTRLEEQQGRVSASPSKDSENAKRNSKQSKVQFSDVTDYESDSHGERLRRERRRARREARKTEGELGMSDIELDLSSPDVQGRGEIDSSLDGMDDEDRRLSELLSKMSLEGASKMSLQGRNSKDYRRNRKAGSLYSSDFEEGSEDYSYDGSSFANKSLLSNGEELEDGVSEIGGAHNNKYCKHSPTFSMKKRSQDYYKKLPRLLRTSELREKASKLKEKTXFXPTGPFVNHECMTSYKTAYERALALVRGRSLPEHYTDLWNRTSRMTFSYLPGMPGTEKTVFKDKKGGERRLDLPRGPSGLKGILGDVDMNDFYREEDELIYYIKPDELKTVVESSSKNDDSSDDSSDDDDDDTTLSATLTRATSESYTLKLKSSLGSETELSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRM5</accession>
    <name>A0A6P8HRM5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294327</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557773.1">
        <property type="nucleotide sequence ID" value="XM_031701913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRM5"/>
    <dbReference type="GeneID" id="116294327"/>
    <dbReference type="KEGG" id="aten:116294327"/>
    <dbReference type="InParanoid" id="A0A6P8HRM5"/>
    <dbReference type="OrthoDB" id="5986202at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557773.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="56826" checksum="9DCCDEE128EA630E" modified="2020-12-02" version="1">MHMTICPKHRAEYGIRWRSCKINCTVPEEELALHKFGKAKGSDRVNSRHSAFILRKTKKLIAVGSPMCRRCNQYITSLVEDAPQGVCPTVTVKPPETLSEVKDSTDSDVSEGLTEQFSKLVVRAEHDETFLSPESSSMASSSDADQALKVEDPRDKLNEFLCSCNILPVEKAWSEWNEVSEKTKKRYTKKATEVVSSVLKTLYPNDTSSLWLALVASPDMNKALAIDDVPHSTKNYLEALAEAYNNAERWDTRRQILSIFSGVADFQTISRYLPGITKYRYTLANLRGKQYGVGAPVPHQTTTTRIRIDLKQLDHFLCFITSPHIIQDLPFGQRRLKLSSGQVVEVPNVIRTLIPQRIVRQYLQYCQETGFKAFSERTMLRVLSECSASVRASLQGLNYFAAEGAQAFDDLVTLVHHICELGPGKEWESRVVESLKASKIYLKGDFKTHLSETSTVADHCIIRSLSDPTDKDFQQKCKYHQHDELCSQCEGLKSILLIRYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSV8</accession>
    <name>A0A6P8HSV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 101-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558308.1">
        <property type="nucleotide sequence ID" value="XM_031702448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSV8"/>
    <dbReference type="FunCoup" id="A0A6P8HSV8">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="GeneID" id="116294791"/>
    <dbReference type="KEGG" id="aten:116294791"/>
    <dbReference type="InParanoid" id="A0A6P8HSV8"/>
    <dbReference type="OrthoDB" id="6082754at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029371">
        <property type="entry name" value="TMEM101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31034">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31034:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15111">
        <property type="entry name" value="TMEM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558308.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31060" checksum="8D090F7FCD6AB25B" modified="2020-12-02" version="1">MGFFEKFVLLSDLIGFFLVTRYPYFDLFCMLMKLGRSTDKYVGTNKAYTPSTSIFSMEMLRENFDVYLHGSIYFVCATGMTLDIGRRNCGLVSAFHIVYLAISTCFENKQYWSEFMMVKVVARAVAVVACYLFIAGGLTDSRRGLAKVSNFLQIGRQLLALYLFYLAYMLWINREDRIALVKHIPGGIIMLIVVVVIYVGCGLCIYGGYEAGYFGKLATWQLLIITLLSDLDTKFWYKANDRIDHWTQIQLASRHFAVMGGLILLGRKRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSZ7</accession>
    <name>A0A6P8HSZ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-4C adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555805.1">
        <property type="nucleotide sequence ID" value="XM_031699945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSZ7"/>
    <dbReference type="FunCoup" id="A0A6P8HSZ7">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="GeneID" id="116292602"/>
    <dbReference type="KEGG" id="aten:116292602"/>
    <dbReference type="InParanoid" id="A0A6P8HSZ7"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555805.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40107" checksum="C6F0EEC15EBD1C86" modified="2020-12-02" version="1">MPNQSNNASETLVSVFYTTHLVSFVLMVFLSITTVVGNGLLLLATWKDPFRSFRNPTSILVASLGFADFLTGLIVDPLAASINLMAYLKRLQVREDQIYKQIASFSFSFSLVTMNASFMTVLALTCIQVIAVSSPHEYKDKITKLKCLICVVCIWGYTTLFSLLPVMGVSTDITAQLDLHINTSTVLLALVLAYAFLYRSYRTHLDSESMRRSGTSQFQRRRNRRQFTLLNLLLAAFVIVFSLPIEVLGHLKFYWTSSNPNQRLKYLIAYTIAGDIILLKFALDPFAYALRLPKYRLAFKNILYRSSYRVPQSSHLGPPLRSSYEFGVDSRVTGNEVKQLGVSVKEDKTVPSELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT21</accession>
    <name>A0A6P8HT21_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031555787.1">
        <property type="nucleotide sequence ID" value="XM_031699927.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HT21">
        <property type="interactions" value="1428"/>
    </dbReference>
    <dbReference type="GeneID" id="116292584"/>
    <dbReference type="KEGG" id="aten:116292584"/>
    <dbReference type="InParanoid" id="A0A6P8HT21"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF74">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CS" evidence="10">
        <location>
            <begin position="43"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="315"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="891"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555787.1"/>
        </source>
    </evidence>
    <sequence length="1030" mass="116504" checksum="C8E33F3657756926" modified="2020-12-02" version="1">MAIKCQHQQHDQQEDQFQAKKSLIDEEKPQDQLSANVQEKYELQHLKHDWFEKDKDSLKVTVYIKNLKKEHLNVSVMEDELNVQFATSDEKFLNMYQGTTENTVFNWNVKLRGKINKTKCSFKILMYMIEITLNKATPGSWKSLQPPNLTGLQAENSDKEFTKIIPDSPIKPPVRNTNGEAVRNTNQEXDQTVPQSSLSEKEHKVNGINEPKHCNGIPDNEDSSTWNGASVNSKSAPYGCNGTPAHPPAPPPTPPTAPLIPPTKSGVIGGGRTPSNGSMPFSEAIHNAAKTGDDMDENNTDMDFLAESSVKKGFTGLENLGNTCYLNSIVQCLANTRPLRDYFLSGEYEDDLNSENPLGLGGHLAQVFANLMKHMWSGKHRHVPPQQLKGFMQQDAQEFMAFLLDGLHEDMNRIRIKPYTEEVEGGSRPDHEVADEAWSRYKRRNDSIIVDLFQGQLKSKLTCPVCKKISIKFDPFMNLSVPLPKEQKLLNVIVFFKDPSRTPMKLVVKVAQEANLEQLTSGVEKKTGVMEENMRVFEEFQGKFHKFFERGSSLANVVSSDNIFIFEXLSIEEAGEEVYIVPVIQRLLYPLTIPLHCADCFKNEDLNDPLKRCLGCYAIGYCDRKCQERHWPAHKRHCKKGGKHSIGLPFIVSMPASQATFTRLKDLAEEYAKTPFLQSDQPLDLTNRILALDWRNNPKTKNWVNVKNKEVECERHPSCESEELSTSYSCTLNECLELFTEPETLGKDDAWYCPKCKTHQQATKQLSVWKLPEILIIHLKRFSFRNVLYRDKITKLVEFPLRGLDMSMYTADKGHANDVYDLFAVSNHMGSVNFGHYTAYARISEGCHAQEQRIGWRYCDDRSVTNSSEERVVSKCAYVLFYQRRRTSESLRNSFGNQSVPTTFANPSSSVTKEPALGDLSYNHNGISSKERPESSTHVEEESRTNEERCSVSDKAVPLTNGNVRTFTTNEPEINDKSKSEAPNVITSDSLSNGDGLKQQGMSSSTHSTSTRDSSNPYIDQSEVDESELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT53</accession>
    <name>A0A6P8HT53_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558403.1">
        <property type="nucleotide sequence ID" value="XM_031702543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT53"/>
    <dbReference type="GeneID" id="116294863"/>
    <dbReference type="KEGG" id="aten:116294863"/>
    <dbReference type="InParanoid" id="A0A6P8HT53"/>
    <dbReference type="OrthoDB" id="6700039at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028304821" evidence="1">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558403.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22826" checksum="4FB6CBA3861E656D" modified="2020-12-02" version="1">MLFKLLCLSLLCCIASCTRREQQTCGEEKFYCPSTKECLNRDLRCTNKKVCVDLESGQENNCFEERPGRYRYYKKQSPLLSSGSSKSKRLVKGWNFKHWFLEYRGFAYEFGTYGHQELDVNDPNYKYGPGREKVVKEELLGTSSCTRDDVLGFRREFMAANPKYKLHCNNCQTFVEFLAEKLKNDCSPTQNKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTS8</accession>
    <name>A0A6P8HTS8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Substance-K receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556100.1">
        <property type="nucleotide sequence ID" value="XM_031700240.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292890"/>
    <dbReference type="InParanoid" id="A0A6P8HTS8"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="11">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556100.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41717" checksum="C104D372F7E4527D" modified="2020-12-02" version="1">MLLMNTTAAAMANATLSGLEFEDTFPVKIIKVIAYCILFLVSSTGNLFIIWATSRDIRLRSMTNILIANMAVSDLLVPLFSIPRHISYIILYPGIWLIDGDFGLVLCKLAFYLQDVSLGVSIYSCVFIALDRFYAVVHPLRGGLSRRKLKYIIPGMWMLSMATFSDYFVSVSIVKTDDSTKCIQDKKRIGVTTNQHFRIYYIMMFALNFGIPLLIISFLYLRIALKLRRXAVPGQARXTSSVRERQNKNAIKMSAVIVSLFFLSWFPFTVQLFLILFGNLQSLSPTTWNNLVFSVFFIAESSCSYNFFIYLVFTQVYRQNFKNALSKCTCFNFSSVRFRTTNSFALEIVATVEQEELDIDGTNDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU22</accession>
    <name>A0A6P8HU22_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dorsal-ventral patterning tolloid-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116292971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556205.1">
        <property type="nucleotide sequence ID" value="XM_031700345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU22"/>
    <dbReference type="GeneID" id="116292971"/>
    <dbReference type="KEGG" id="aten:116292971"/>
    <dbReference type="InParanoid" id="A0A6P8HU22"/>
    <dbReference type="OrthoDB" id="6116165at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF50">
        <property type="entry name" value="ATTRACTIN-LIKE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="27"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="149"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="266"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031556205.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50509" checksum="136D90E40B8B0932" modified="2020-12-02" version="1">MGCYDDVLVFILILVTLYHRLLAISICEVNLIQAQEGEVTSPNFPYNYPSNTNCTLVIDVGPNNRIDIEFKDFRVEENDDMPGSCLSAEYLEISEGSKNKIYCGYKLPTRYQSTASNVTIRFITDKHINYMGFRLLFSTSRKVLADSICPTRYIKKDMSGSFSSPNYPNLYTNNEQCRLTVSVPDNYMMNVWFTAFHLQRSLVCSNDYLLIKDENGGWKMCGGGENKIPKRMKFVGNTVRMEFKSDSSVGQRGFLLHYNMTRLREGQCVCTQGLEYISINNFKSKIRRNNNVIKFLFKTSRPNGLIMFSKGRLRDYIYIGISNGRLFYQADLGTGSGRVISPGRSLNDNKWHKVQITRQDKIITIAVDDRFKGYASTRGPFNRLDIPDSIGFFLGAPSSIKGLVGNFVGCIRDLQVDELESITNAFAGKPFHHTFGRERFRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUG7</accession>
    <name>A0A6P8HUG7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Tyrosyl-DNA phosphodiesterase 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116295396</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559050.1">
        <property type="nucleotide sequence ID" value="XM_031703190.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559051.1">
        <property type="nucleotide sequence ID" value="XM_031703191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUG7"/>
    <dbReference type="GeneID" id="116295396"/>
    <dbReference type="KEGG" id="aten:116295396"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="101"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031559050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559051.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39143" checksum="1466EA11A1C4EF8F" modified="2020-12-02" version="1">MAESAISVDDLEKINILKEFTDITMTGEPTAIQYLDKHQWDIAEALNSYFSSSQGHGMDENSGTASHPILVDSSPISKSMGVSSVRVDGEQNAKDDNLILLTWNIDGLSEKQLVERTRYVCELINTRRPDVVFLQEVIDDTLLVFHQRCKGYTTVCGKRASGYFNAIMLKDQTVKPAGPLEELYFSRSTMGRHLLMQPAIFNQQIKVVLMTSHLESTANCKQERKRQLEIVFNKMLSQNPECTVIFGGDTNLRDVEVGQVGIPNEISDDTKFTWDISVNDNQDWQFPNKPKLRFDRVYARPGQNENCLEPLEFSLVGKQRLASGVYPSDHWGIWCKFVKKTAEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUN1</accession>
    <name>A0A6P8HUN1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="10">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116296273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031560139.1">
        <property type="nucleotide sequence ID" value="XM_031704279.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUN1">
        <property type="interactions" value="1790"/>
    </dbReference>
    <dbReference type="GeneID" id="116296273"/>
    <dbReference type="KEGG" id="aten:116296273"/>
    <dbReference type="InParanoid" id="A0A6P8HUN1"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="13">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="12">
        <location>
            <begin position="244"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1283"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="876"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="909"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="942"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="989"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1079"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1291"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1301"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031560139.1"/>
        </source>
    </evidence>
    <sequence length="1339" mass="151599" checksum="E566A7BB549ECD54" modified="2020-12-02" version="1">MSATYLDVSNTLDRNNLPFISSLSSDAGISMEQMMEELDDEIVEEMPKIKIGICAMNKKTKSQPMQEILSRMIRFDFIEIIVFPDDVIIDKPIEDWPLCDALISFYSSGFPLNKAIKYAELRKPFVFNDLEMQFTLLDRCAVYSLLESANIEMPRYATLLRDKDGNPVDTDFVELEDSIQIGNVVFQKPFVEKPVNAEDHNVFIYFPSSAGGGSQRLFRKVGSRSSVYSAESSVRKFGSYIYEDFVHTDGTDVKIYTVGPEYAHAEARKSPSLDGKVERDSQGKEIRYPVILNPYEKEIAHKVCKLFKQTVCGFDLLRTHGKSYVCDVNGFSFVKTSKKYYDDCAQVLVNCCLQQLAPRLYKPYNIELDTEDHGTMPETLDGTMLELRCVVGIIRHGDRTPKQKLKMEVRHFRFLELFKKYNKSTDKKLKLKQPKQLQEVLDIARYMLEEIEANPETSMFEKPNKLRQLKNVLEMYGHFSGINRKIQLKYLGKVKDSSENSGGEEKQSKQSTDSESEKSLKVKERDSKEEALLLIMKWGGELTQAGRVQAEELGKAFRCIYPGGDGDYSSLPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGFLALEGELTPILVHLVRSDKGTTEMLDTSDQATKFMAKYGIYKVNDIQHNSRLGLHSTEELYDCSKALADIVIPQEYGITAEEKVKISQTICQRLLRKINGDLKAADVTDTTTTRLNPKYSQSVISPHRHVRTRLYFTSESHVHSVVNSIRYGNLIDVDKADEQWNRALEFLGEIPELNYMTQLVLMLYEDPTAEVGSDNRFHIELHFSPGAYTQDEKKHHQIRGKSAHPKPSRPFSEENEETTGQTDTTERQTDTTERQTDATERQTDTQGNSTLSSQVTKITDTGDSHDEQPEEESNSSLKEEKGEENLKTEEHGTEESKETSKVDGSNLEQTAEKPYESTLYTDDKTYDGNEQSRCAIGMDDFTDPTGSPIQSDIQYELSHEEKTEQNEGQDKIPSEEPLRRRHSGHDTFVSHRQTFSRTSSESDAVPFGIIEKLHSRQTLSENNIFVQHQPTSHHQPTSRTKGSQSDDTFHQHPDNIKEENESDHGNDLKPKLIRARSQSTSCIEGTPEYDEGRGERSASDSSSNDSQRVTSTAGSAKSDSLVLDKRKEKDAKNLRVIKSSPIMKKSPVRRHHMSTAWRHSSPESLFQDQKRGTLIYLPSIRAVSKKLSLAKHGPCRIRPLAPLSVDPKKPPLAEFYDQILSPIASIYPLLTLHNSIPLNIMESFLDRLTEEKSGESDVSSASTPATTPTRKHPTKRLSLKSSTHEQVLANNDSIVSFEGLDLIEFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUN3</accession>
    <name>A0A6P8HUN3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556317.1">
        <property type="nucleotide sequence ID" value="XM_031700457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUN3"/>
    <dbReference type="FunCoup" id="A0A6P8HUN3">
        <property type="interactions" value="1197"/>
    </dbReference>
    <dbReference type="GeneID" id="116293063"/>
    <dbReference type="KEGG" id="aten:116293063"/>
    <dbReference type="InParanoid" id="A0A6P8HUN3"/>
    <dbReference type="OrthoDB" id="262308at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02959">
        <property type="entry name" value="ERp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051099">
        <property type="entry name" value="AGR/TXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037462">
        <property type="entry name" value="ERp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337">
        <property type="entry name" value="ANTERIOR GRADIENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15337:SF11">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556317.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19798" checksum="05816B277AE1162E" modified="2020-12-02" version="1">MEQTNRTNINLSTRLSLALVMGFLVVFSVVSPCLSIDSRGWGDDIKWKTFEEGKEEAKTSHRPMMMVIHKTWCGACKALKPKFAASKEIAELSKKFVMVNIQDDEEPKDPQFQQDGGYIPRIFFLDSFGQVQKDIINDGGNPSYKYFYGNANSIVNSMNSALDKMIQGVRIEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVM9</accession>
    <name>A0A6P8HVM9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline-rich protein PRCC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560464.1">
        <property type="nucleotide sequence ID" value="XM_031704604.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HVM9">
        <property type="interactions" value="2538"/>
    </dbReference>
    <dbReference type="GeneID" id="116296567"/>
    <dbReference type="KEGG" id="aten:116296567"/>
    <dbReference type="InParanoid" id="A0A6P8HVM9"/>
    <dbReference type="OrthoDB" id="206969at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560464.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="57708" checksum="3477C5A0A9512607" modified="2020-12-02" version="1">MSLVAYGDSNDGSSDSEGEGNTNFPPKTSSFSACEPSTSSAKRVEETTPSTSTASEDVTLTNSGNRSRLSSLLPKPNNPNNATAVLRSNFSTLDTQNLDEDEDEIIEVEEEYVPLSQIKKDKKTPVSVANEEQKSVGSLFSRMPSPWSFGTGISVGKKKGSEDDEDDKSRKRKQPVRIVAPTISEDDLDDDDEKEPTAKKPMKSKTGSGLSSLLPKPRHSITTTSYNPNKPIAKLSNRPLIPHTLTKKPAPAKKNAKKGKKSEDDGSGDEDDGEPVAFFXFSEKKSVIDTNVPKDVKKIKLETSVMSVNILGDENPIDVPKTHNKSETITGSLEVNSTEYSAPMSSGKPGVESAHASVSYVGEGSPYGSTSAVSHYYDTSEGASTTYYQPTAGPSQQYSGYGAYSENPGYYDADGTQGMYNQTYGGYAQEQTNEQTDDIDMEKLKRLQGKRNCNEQINIIDINAADQTGDTQLQMTKITSEQIAHRPSKKKGNMPSSQQRRKHQITYLAFQVCQLDNALKVSCVWQHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVX0</accession>
    <name>A0A6P8HVX0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Octopamine receptor beta-1R-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559498.1">
        <property type="nucleotide sequence ID" value="XM_031703638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVX0"/>
    <dbReference type="FunCoup" id="A0A6P8HVX0">
        <property type="interactions" value="700"/>
    </dbReference>
    <dbReference type="GeneID" id="116295727"/>
    <dbReference type="KEGG" id="aten:116295727"/>
    <dbReference type="InParanoid" id="A0A6P8HVX0"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="40"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559498.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38439" checksum="C89F2724BE3ECF60" modified="2020-12-02" version="1">MMDNQTNKSSFPSKDNSTSPRSLDWYWTLRWIIGVFIISGNSIIIITVMIRRRLRNNIPNQFIVSLAVADLLTGVVIIPATYHCSFHECDWSTLFTAINFLLFSSISNLCVMTLDRFLAVVFPYAYQTFMTQRKALFLMAVAWVIPFIVSVIPIAWKYKQPSEKASYEKTFMILQTLIIEITPCILMLVTHIPIYLIVRKHSRQIACQNASQVNNQSQSKAKNERSTVKVFTLVVFLFIVCYGFSIYREVCRQLELCNPPLQITLVSRLLYLSNSAMNPFVYSFLKRDIRQVMKQALTSCLRRFGETVDLRDESESSRRSRQPHPREMGQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW69</accession>
    <name>A0A6P8HW69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">28S ribosomal protein S22, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556842.1">
        <property type="nucleotide sequence ID" value="XM_031700982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW69"/>
    <dbReference type="FunCoup" id="A0A6P8HW69">
        <property type="interactions" value="1347"/>
    </dbReference>
    <dbReference type="GeneID" id="116293539"/>
    <dbReference type="KEGG" id="aten:116293539"/>
    <dbReference type="InParanoid" id="A0A6P8HW69"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019374">
        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031556842.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38016" checksum="254C92F963DE55C9" modified="2020-12-02" version="1">MAAALTSRFYRFFSINSLPIRAISTSKAHFTGGKILSFDDERVRAILKRLTGCEVEKVLSRRPQDVSVPTYKIMTNEELLEAEKETKARAEELLDMPPVMEERQEIDEVIDIDERLSGYDTANYVFTDISTSVDDRTRRIVVREPSGRLRAATWAERDASNFIYFPKEGRKWETPEMLTESGIQVPLSQNRHEDILDLVCVQFEPDTADYIRVHDTIYDNINKENKFELLWSTRHFGGLVYYLMKHKNLGNLLDYFTENEYFDEAVDLINFHHLVYPDHVTATQAKSSKLSGIQMLRAYLKREGPLSSLQTVEEQFFKDNNSSKSGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYC7</accession>
    <name>A0A6P8HYC7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Stimulated by retinoic acid gene 6 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116294254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557675.1">
        <property type="nucleotide sequence ID" value="XM_031701815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYC7"/>
    <dbReference type="GeneID" id="116294254"/>
    <dbReference type="KEGG" id="aten:116294254"/>
    <dbReference type="InParanoid" id="A0A6P8HYC7"/>
    <dbReference type="OrthoDB" id="5966836at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034632">
        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071939">
        <property type="term" value="P:vitamin A import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF15">
        <property type="entry name" value="RECEPTOR FOR RETINOL UPTAKE STRA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557675.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="63537" checksum="035EF6AD3C6AC797" modified="2020-12-02" version="1">MFFGASAASKDLQGSAWSKAFQGILMTLVYGIINYPYLACLNAEYKIIGYAMGLIYSFVRFIVDLFLYFGCTPDKESGQHLKNANIEYIMYGGILTNIPVVVCTLFLVGSYSVLLYKEIKKLRVQGLPSLRYKEEATTITLAGKTERAHVNLLFSNQLHQAGKRPPNQNGTWYNLLKNWIYVARPDFKFSTQFLSSFVVSCIFVYQVTVVLLMLITVIISLLKPFLKAMLERNTGLDEALVALQLFQDYSIASVLLACLFAIMQLGFFLRSHRNDVLKTYRTKRGLLPDEILHPKILVGKSLSFCGHQTAFTAIGLLVNVLSVFFLLLPIFVFHLLSKIRTADENSSRILNVIVDILPLIVTPIFTSIAVILLSHFVFKDHSYPDMSITVNNRRLFGIMSYFFFFFNIFVGLWSGLLRVVKGAVIVLVFLPRVDRTIMMRGYRRFDKAYMAYIGFLSVLVAFKHPVMLCFCQLLLEGVRRREAGQTTIASRPRVSGKALNRWFLVVLLMHNPSLVRHRKQGVRPRVQLPSTSDVKVEVSPIDLEDTFPPAERLKSLDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYH5</accession>
    <name>A0A6P8HYH5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein NLRC5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116294252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557672.1">
        <property type="nucleotide sequence ID" value="XM_031701812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYH5"/>
    <dbReference type="GeneID" id="116294252"/>
    <dbReference type="KEGG" id="aten:116294252"/>
    <dbReference type="InParanoid" id="A0A6P8HYH5"/>
    <dbReference type="OrthoDB" id="5985050at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="150"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031557672.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40601" checksum="AE7D79D3AE0CA67C" modified="2020-12-02" version="1">MKGSWLEDIHEPVQDWSHDQMFSEGQERPEPEKLNDDEFKMKRYRASETHQYLLGLKETREKSKASFKRQTVFLLSEEEDEKNRTDDIFTNVTFKLVTKHFKEPDERRFGRRQFDEIQESCTKLKNCSEIFVCPENDDQKSTASCKTNPKSILLTGKAGIGKSLFCRMLVRDWSHNRLFEEGQENAKVPDFQFVFMLTFCQLLEEEEKRFDLCDILNQSSLLNEHLVIDESLLQYMIENPEKLFIILDGYNEYKPHREKITGDFETRYPNDPHEKIPVPALIAKIMKGKMLNGAVVLISSRPGEAEELKEILFDVRCDIQGFSSLQVLEYIEKYSREQKHEEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYH9</accession>
    <name>A0A6P8HYH9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116294258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116294258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557677.1">
        <property type="nucleotide sequence ID" value="XM_031701817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYH9"/>
    <dbReference type="GeneID" id="116294258"/>
    <dbReference type="KEGG" id="aten:116294258"/>
    <dbReference type="InParanoid" id="A0A6P8HYH9"/>
    <dbReference type="OrthoDB" id="5964872at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027937661" evidence="4">
        <location>
            <begin position="21"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SEFIR" evidence="5">
        <location>
            <begin position="437"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031557677.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="66952" checksum="3EBE8E1D0FD93359" modified="2020-12-02" version="1">MKNILGFYVIVLAFCGFESAMNVNDEPDLCASLCSDLSNGFPEENPKNSDLNKILQDSLVEKKCDCSNINKSDLKRKRRSVATSSVPKPTISIGNQTNENSANEKNNVTENNDKDQGEIPGFSPNKGIKFVNPSPYCNYTVREGQNKRKTKYIKSIDVAFTDPAQGSFNVSWEPPKADLDNVTDFLVLWNSQPKPNELPDFDKNFVHCKAVPKNQSFAIIQENTGWEYPQKLYLTVVTIPQGLYGSLIDLQTFNPMGNPIIVPVPPKKYGKDVTLQTGSIAGGVIAGVAFITVLFVLLYRRKCVHSETPDNESKYHILPVIDLKIYTSIIYFFLPSIHSSIHPSHPSIHPFIHPSVRPSIHPSIYLSIHSFLPSTILPSTPQSVEPPHLSMHLSHVVTIFDLILIVGITIPFANNADGLPKILNDSKPKNVDIYFGSYLPESEKYANEVATIASMLRAHGYRVIFDQVDSVELNSMGFNLWVEKQILEAKKYIVFCSPGYLKLWQTLATNVQDDKLNHINKEDLVRVRYEIKRITDIYSESCSTSKIICIKMDQKLNMKSLPPWMNHNMLLWPEQKYDIIRRLNDQAAMIMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYL3</accession>
    <name>A0A6P8HYL3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein NST1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560488.1">
        <property type="nucleotide sequence ID" value="XM_031704628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYL3"/>
    <dbReference type="GeneID" id="116296590"/>
    <dbReference type="KEGG" id="aten:116296590"/>
    <dbReference type="InParanoid" id="A0A6P8HYL3"/>
    <dbReference type="OrthoDB" id="10461905at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560488.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="47746" checksum="48FED5A4DD95D521" modified="2020-12-02" version="1">MKVGSLAETSAQFIRESHKAVHDLDYIHSMCGGDLIFLPPGYNEACYHAINLARPFLAIVTTGMGGEFERLCRSLNIISKDASMAKQNFPLLFYAKAGTVDGEEILSRYTSSGHCHGLDVFLCVPDQSEDLSLVIHEYGADFNGILNAIANCSTTLDNYRALRNQQSQHRGNVIQVDSEEEVGDSEVQFGGLVSPSSTGDESTLIEENDTPQTREGRMEKEDKEKRKMEERKKREREEREKREREEMEKIEREEREMREREEREKIEREEREKREREEREKRERDEREKIEREEREKRKREEREKRERDEREKREREEREKIEREEREKREKEEREKREREEREKREREEMEKIEREEREMREREEREKIEREEREKREREEREKRERDEREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ83</accession>
    <name>A0A6P8HZ83_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116296683</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560601.1">
        <property type="nucleotide sequence ID" value="XM_031704741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ83"/>
    <dbReference type="GeneID" id="116296683"/>
    <dbReference type="KEGG" id="aten:116296683"/>
    <dbReference type="InParanoid" id="A0A6P8HZ83"/>
    <dbReference type="OrthoDB" id="10283167at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031560601.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="51000" checksum="D94353BF0A9CEE6E" modified="2020-12-02" version="1">MREIISIQVGQCGNQIGSQFWRDISQEHGIDFNGFYHGTSELQSEKIDVYYSETDRDNCFVPRSIMVDLEPGPLDAIRGTDLGLFFRPDNFISGNSGAANNWAKGHYSDGAELRDAIFDVMRKEAEKSDCLQGFQMFHSLGGGTGSGLGTLLLSKIREEFSDRIIMAISVVPSPKVSATVVEPYNTILSVHQLVENADEDLIVDNEALYDICTNSLKLAKPTYPDLNHLISRAVCGMTASLRFPGQLNGDLRKLAVNMVPFPRLHFFIPGFAPLTSRSSEQYQAFTVAELAKQIFDAKNMMTACDPSHGRYLTAAAIFRGRMSMNEVDNTMRDIQNKSSSSFVEWIPNNLKTTVCNVAPSRLKMAATFVGNSTAIQEVFRRVGEQFSAMFRRKAFIHWYTGEGMDEMEFSEAESDMFDLVSEYQYFEQVDVLTGYDTDEEINEDEEIVQDDQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZQ0</accession>
    <name>A0A6P8HZQ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein piccolo-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116297706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561849.1">
        <property type="nucleotide sequence ID" value="XM_031705989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297706"/>
    <dbReference type="KEGG" id="aten:116297706"/>
    <dbReference type="InParanoid" id="A0A6P8HZQ0"/>
    <dbReference type="OrthoDB" id="5969886at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
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    </dbReference>
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        <property type="entry name" value="PR-1-like"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027894555" evidence="5">
        <location>
            <begin position="24"/>
            <end position="2693"/>
        </location>
    </feature>
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        <location>
            <begin position="2061"/>
            <end position="2097"/>
        </location>
    </feature>
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        <location>
            <begin position="2122"/>
            <end position="2159"/>
        </location>
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        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="564"/>
            <end position="607"/>
        </location>
    </feature>
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        <location>
            <begin position="748"/>
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        <location>
            <begin position="809"/>
            <end position="868"/>
        </location>
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        <location>
            <begin position="967"/>
            <end position="1726"/>
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        <location>
            <begin position="1759"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1908"/>
            <end position="1969"/>
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        <location>
            <begin position="2169"/>
            <end position="2362"/>
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            <begin position="2408"/>
            <end position="2468"/>
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        <location>
            <begin position="255"/>
            <end position="282"/>
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            <begin position="510"/>
            <end position="526"/>
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            <begin position="567"/>
            <end position="577"/>
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            <begin position="578"/>
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            <begin position="1060"/>
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            <begin position="1077"/>
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            <begin position="2201"/>
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            <begin position="2408"/>
            <end position="2420"/>
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            <begin position="2446"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
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            <dbReference type="RefSeq" id="XP_031561849.1"/>
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    </evidence>
    <sequence length="2693" mass="293053" checksum="9B32CF155B28AA37" modified="2020-12-02" version="1">MMILSAIILRILFLVLWISTATGKAVPAPSNRLLKGCDKACQIECIEVLNEYRANHDAPKLKFSQELADKAQKWAGGGKFGYDMDARGKYGQLIEWDVKDELPSFKSAIKHWHDKEKDFDFIAGKSKNGNTLHDFTQVVWKKAHKAGCGRGKLFGSRYYVVWMDADGVISPNSTEGSENVGPPKRADIHWFEITKIKAVGEPLYWNSTNSTKPSTGNPNVRVKTSLLPEEDEDFNSVESEANVLNDANNIKQYVHDSLSSVLAEENREVSKLRDEFEGLDDVPNVRLGGTSQDLYKGMADDNIYDDRESGTKQIKPVAEPMKWNKGIRKLPSNNGRKFQKVASKYQKNPNQMDSPQLQVPMGKLPVTVDAGETKLTESSPTTVIHEELNISDKNTAAKAAAPKPKQVKNNVAAGKRYGNKSETSQDGGKEMSGMIMGKLSDNGTGNYASQRPSNDNILRITSDENLSPDMENELSKVSKFINTRLKVLNKHKEFQGTPGRDLKNGYNAREQGKPEDPMNAKMEDEPEARPARITMVGAPLSFPERKHKDIVKDIHEKVNALWNEHLKSKKGKEKKGKAQSNGEDNLSTQPYQDGFDDSLHGEGSSFSANDEFHDVGGNELHGYQYSANDHHQEAYPENYDQNHLNSPQANKMPQNELNHGNSFHGFLPPIRLHPEGDWLGGPVVPPVSPAFDDPITHAMNTGPGGLYEYRKKYTSEEPENDSGKFLNRKKNSLQSVVDVFEDKEGSVESAYAEKGREPVLQPIRMPKKEASVEPKKSGFKITERKPQDHKELLALPKELTERPDNEMTLASQLPDMISDIPSTSMTNSEESDHPGYFNEEPGLNRPTFVDQNNNQYQRQPTSNASPGLPYYQTRPAYGYTQQQNSPVVQSQAGHPSYPYEYNQPYQYNPMMGVGLPQGMNQGYGFNQQQEPIHSVQEQTYDQGYGYPQQSQVQGSMPSMPQVAVISNGKPEQQFGNAPKPVQPQKILKGVSLPSSMGVVTDNEAQQSPLTLSDKNTKSPEKKPLGAKEIDSVPLTPSLPEEPTDEIKGEESESDSKGSKNNAGGITNLPQNSLPRQGQGGISGPQGGLSNMPQNQPQNGMPQDGSSNGATVTVDGKPVKGPYTSSGVYKVKGPFVYQTDTTIFMGGPQNSDSSKPNPMNGGGSQQVATSNPQNVPPSVDNTKEQQHKQDNENPEKEGNQFQPELLKRPSLITLLKEAEIKKENQSESKENKEKPDGNKESEKMPEGSTSSGERPEGSGESEKLPGKPAESEKPSGKPITNGKETEGSSENKGQPIGVTEGQKEKQGPSEEAKPQNSSGKKEQPVESSQEGSVGSSAGKEQRQESSGKEDPNSQLKIETEPNGPEDNENTPGSTESQKQTGGLKSKENQNGSSIGNETPSSATIDQTNSTGTGSMPNGLPGNGRPPSSSSEKEKPTSGSSENEKPPGGSSEKEKSTSGSSENEKPPSGSSEKEKPNSGSSENEKPPSGSSENEEPPSGSIDQSGSSDIQKPPSGSIDPSGPSENEKQQSGLSENGKKQGGSIDPSASSGNEKPPSSSPENENQQSGSIDPSGSSGNEKQPSGSSENEKSPSGLSENENQQRGSIDPSGSSGNEKQPSGSSENEKSPSGLSENENQQSGSIDPSGSSGNEKQPTGSSENEKSPSGLSENGKPQEGSIDPSASSGNEKQPDSFIDPSNSKTSKDESNVNENQPTDSKEIKTPPQNHHQQNIFQTKPETLKSEAQENYPYDLPKGAHYEPAIEAPNAMNSPSGTATGKQPLQDQHNSAHIESKAVHSKLMKAKLLLPFTHLISNINHALGLDTPNSTLKINHISLSSKYPSGKTSQAVKPVIGNHVESSQETPPQGRIEKAASHQPIAVDVPEGNAISEVGKPLRHLTERHQNQIQDVKVDKPDLPTAHNGSIGSGSLMEGHRPFVDTSGIHYLSKGQKPNTTSDQNKHTFKQTTASTPSRIQGGNLLHVSADHGSKTPLVVQHNAGEHFMSDHQVRLHATPTLHKQLKDEHIPLGSVTGMGDGSHSAGPPHLQEINESPIVEVTHPGSLNTQNCKDDGERCSLWQKRGHCQSVLYAGFMKRHCKSTCGYCALPSIVVQSERANAGIRFAYEEHACQDSTNYEFSCPTWKAQGYCQKKEKEMRIFCRSTCNFCKRKKISKKKNKAADETKHMNDQPGKTAHAQTGNTSGQPQSYAHAQTGQGNGAANAQAAGNSAGQQQPNYAHAQVGKPSEPQSTAYASGGSTYVQTQSSGGQQTGYAVASASASPEQQTYAHAQSSSQSGQPSTAYAQNKPSPNNKGSESSTAHAQSGSSEKPQNVAHAQTLPVNDDPKQSLNSKNRDEGNIVEAPNSRLHGMSLEERVISESPEYKTSNTDYYIKAGNSDETAASEVNLYDETPQIRFSNKNPVESTNNYVGTEENFDPGLEQNAESEQGSSAMGKFSDEAETKAEYSKNDLKDMEVKDTEDEKVQMLINRYDPVMPSEQDDGDLADGKSIILTRTPDKKGTLDFVSTEGCDQSCQRECLDAINSYRRNHNARPLVLDQDLAAHAQQWADSKTYGHSPWSQRGMGGELIAVGSFYKTFTAAVKAWHDEEKDFDWEKGELKKGKEIKHFKQLISKDAHVLGCGKSMVNGEPYYIAQMDAAENSEKRETMEKPEKPDLGWYMESSPYWKDLQSREKIPNKVHRNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I011</accession>
    <name>A0A6P8I011_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116296892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560861.1">
        <property type="nucleotide sequence ID" value="XM_031705001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I011"/>
    <dbReference type="GeneID" id="116296892"/>
    <dbReference type="KEGG" id="aten:116296892"/>
    <dbReference type="InParanoid" id="A0A6P8I011"/>
    <dbReference type="OrthoDB" id="5969161at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031560861.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31799" checksum="2ED1D4873955494A" modified="2020-12-02" version="1">MAILSEEAIEKIGSFGRLQIRILLIISYSILFSTCVLMVMTFITAEPPWRCAANSTSCTMNGTFKVGDNHYEKRCGIPRKDWEFAAEGDFDSIVTEWDLVCKKASLASLANSLLFIVWLFASLLSSVLSDKYGRKAVIFPCSVFTCICALASAFAQRYWVFALFRALAGVGIGGYLAPSFVLVTEYVGVRHRGAVGFGIWFAWVLALMLLSLLGYLIHSWRFLTVIISAPGMLYFLFWWATPESLRWLLTKGKMKDAQKTFKTAARVNRVNLEHDELSVLKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0D2</accession>
    <name>A0A6P8I0D2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium channel subfamily K member 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116296996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560986.1">
        <property type="nucleotide sequence ID" value="XM_031705126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0D2"/>
    <dbReference type="GeneID" id="116296996"/>
    <dbReference type="KEGG" id="aten:116296996"/>
    <dbReference type="InParanoid" id="A0A6P8I0D2"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="157"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031560986.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33659" checksum="E8B62C2979CCC995" modified="2020-12-02" version="1">MFCGYFFGGAAVFMLIEKGDTNYSHFNKTALMEELIRNVTNKYNISVDQFEDLTEEILKIASKKPNAPWNYFNSLSYVLHLLTTIGYGTITPKTKEGQIVTIFYGLFGIPLTLLTLKAMGSHYNETMMKIITAIEVKCLKRNHVKQMELKIVLFNLCITFIYLFLSALKSVSTDKYTYPQSVYVWFITMTTVGFGDFVPKVGADGTSFYNILLGLCFMSGTIDAMVSYQEKKDGVSKPSRWSCLSCCNRKSSSLQIQSASNNTSNQTSIELKGEELVHPNNKQTQTPGIFNHFAQYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0N7</accession>
    <name>A0A6P8I0N7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-1 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116294893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558445.1">
        <property type="nucleotide sequence ID" value="XM_031702585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0N7"/>
    <dbReference type="GeneID" id="116294893"/>
    <dbReference type="KEGG" id="aten:116294893"/>
    <dbReference type="InParanoid" id="A0A6P8I0N7"/>
    <dbReference type="OrthoDB" id="5967546at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="47"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031558445.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="54911" checksum="24FBA5224F87687C" modified="2020-12-02" version="1">MAPSNSSSLLNSKSLEQMRHELSSRDIPLVIAESFLLASISLASLLGNILVLMAIYKSPRLKSPTNYLIISLAWGNLLTALIVVPMSTGVLATGKMFMGVQGCKAFGCMTYLLSNITFYTIGLIAFNRFLLALSPKWYDFFFSTKSTIMTIVSSWVFQFIYAVLPAVTNWSEVFLMPGYTTCALFVTNPAAKVIYRTQSELQMIGGFIIIIMCYTVVLIKIRKTHLIFPEVEASTIMENPRDPQRDPVDQCSRSSRYLTPDVPNSPVTGVTKRRMTSAVCLLEKVPEESTVEKEHDALDQRCNTAGKLIQGNSSDNPDAGKSGDHVKTKDYKNVVPSDFNQEASKAHKYHREESSHDGIGSDSDAAPSDANQVDPELEAQESPADVADSSKSDPQHPHRFLSQMKTTKLLFAITLFFLLSWVPLAVTIVVESYQSEYLSRQVELFGITLLYLGTTFNPVILPIMSRHFRTEFLKMLCIRNAVAVRPQVSAKPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0W0</accession>
    <name>A0A6P8I0W0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD synthase</fullName>
            <ecNumber evidence="3">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116297147</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031561171.1">
        <property type="nucleotide sequence ID" value="XM_031705311.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I0W0">
        <property type="interactions" value="934"/>
    </dbReference>
    <dbReference type="GeneID" id="116297147"/>
    <dbReference type="KEGG" id="aten:116297147"/>
    <dbReference type="InParanoid" id="A0A6P8I0W0"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031561171.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="57004" checksum="DF1283975A3DDE2E" modified="2020-12-02" version="1">MADEQENSKKTATTAGIIIIGDEIIKGHTKDLNSYFLVTRLWSLGVKVRKISVIADDEEAISHEVREFSSRFTFVITTGGIGPTHDDVTMSSIAKAFNETLVENKELVESIASAYQMKKSDLNEFHLRMAKLPPSSDLVYSKDTRTNPFPVIRVRNVYVFPGVPDFLEKNFQGIEHIFSDPTRNKFQLCFIYLSIGETEVVHLLNEVHERFKESVQLGSYPDCSDQDHKVKLSLESESENDWKEACKYLLGKLPPESVIKIEGLPDDKGDAAKTLDVSEVYSTLSPVNNSNISACVKGAWAIIQEVLRQYSLNXICISFNGGKDCTLLVYLVYAAVVKHFGRVPKLNALYIQYESAFFEAEEFIRDATERYNLNLITMKGSIKASLEKLKVSHXQIKAILMGTRRHDPFTEKLRTFTCTDPGWPEYMRVNPILDWHHSDVWAVILHFKIPYCSLYDKGYTSLGSTHNTKPNPLLQIQTDSEDIKYQPAYLLEDDHQERAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I146</accession>
    <name>A0A6P8I146_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561251.1">
        <property type="nucleotide sequence ID" value="XM_031705391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I146"/>
    <dbReference type="FunCoup" id="A0A6P8I146">
        <property type="interactions" value="2121"/>
    </dbReference>
    <dbReference type="GeneID" id="116297210"/>
    <dbReference type="KEGG" id="aten:116297210"/>
    <dbReference type="InParanoid" id="A0A6P8I146"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="162"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="394"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031561251.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="55196" checksum="AD58059FD17F941C" modified="2020-12-02" version="1">MAPGPGDLMDLSAGEANNQHVAAVTRNYISQPRLTYKTVSGVNGPLVILDNVKFPKFAEIVTLTLNDGSKRSGQVLEVSGSKAVVQVFEGTSGIDAKNTTCEFTGDILRTPVSEDMLGRVFNGSGKAIDKGPAVLAEDYLDIQGQPINPWSRIYPEEMIQTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKFKKGVLDDHEDNFAIVFAAMGANMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTTAEFMAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQVYVDRQLHNRQVYPPINVLPSLSRLMKSAIGEGMTRKDHSDVSNQLYANYAIGKDVQAMKAVVGEEALTSEDLLYLEFLGKFEKNFISQGTYENRTVFESLDIGWSLLRIFPKEMLKRIPQSTLAEFYPRDSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I228</accession>
    <name>A0A6P8I228_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Myosin-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116295300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558941.1">
        <property type="nucleotide sequence ID" value="XM_031703081.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558942.1">
        <property type="nucleotide sequence ID" value="XM_031703082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295300"/>
    <dbReference type="KEGG" id="aten:116295300"/>
    <dbReference type="OrthoDB" id="5977966at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1427"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558942.1"/>
        </source>
    </evidence>
    <sequence length="1544" mass="182294" checksum="25FAA2C7B33F73DE" modified="2020-12-02" version="1">MESESQNPRKRQYLLDLDDPNIETHEVSRDTNTTTEVHHKTEVVEEYSEDQTNFKLKFEEAQRNLFDLEEELRGTRDKLNHLHGACENTEEKLSMLKDATFLYQNIVSKHEITFKTVVEENRILKVKLEQAENLQKELDEERENNRLLNDRIIVLERVKEHANEEIGRLDAQQKEYEKRTNAELNSLRDRINEYEVTCTGLRSKLEIKEEELIHLRFQHTEELESLKLELTKKHEDFVIHAEKSESLSQECEVLRQDKALGEENLLKEIESLKTKCDEIDGEKGTLEKEKEEIFNELSGLEARLQDLETLQAERFELKKENEDLRARIEILLIEKSKLEEEKAELEEDLGKLEERMNDLDALQDDHDGLLMKYRELQTKYDELLAENSGFLDQVHALEDEEAKLKDEIEDWKGKYKTVSKEKDELASRVNRLEDVESRLKKEIEDLKAKLEKMREYETNYKSLLKEKENIERKLNDETRNVNDLRRKIERLQKENDELSSKERKQRNRISELEREVRDLTREKERLAQQLKDAKSRADENSKKVDELKDRIRELEKQIKEKDRKLKELEEDNKKLEDELDSLTETLESGKASYMKLAEDLNQVKDENEQLRIELEELKSKPIVVEEAPVAASAPDFDMTGDLEGLKLDLEDANKEKERLEDELKKMTQKYDTMYEELTKKITILEERCETLRKEGVEKELIISQLRRDENRYKERIGELEKLLETAPEDGKYEELSNENDALHKKIKKLEDEVRFLSDELKNADDLSINETAELEKETKVLKAKIADLEKKAKEDEKEIERLRKLDKRKGDDDWKNQYNSLKIKFDSLERDRDMIKREKERLHKDYVDADDELTNIRSRLSKTKKQNDELNIEINTLRIQIREYERNSRSETSNLEINEVKKKLKAKEEEVERLRNELNGIDGEEWPQRYESLKLKYEELDDEKNSLYKEKSELQRELRISAEKVAELEIKISHSNNDEKRFREEIRIYKVKIKELEVRIEKVSIGDKEEIDKLKRRIVELEEEIIRLKKLLMDASDDGKTRDKLQAEIEDLEKEVIILTHEVELKTAKTRDQSKEIEELLLRIKELENQPIPEPQKIQVTETVLEESVPDGVSPWVLPPEPVPKETSTLIVDVICFPEIVLGVLVRSKQRSGYRFQGKGRTLSQYEFQVEPLPGTVLVGVPLAVKVDASETPTLQHPNLIDGIPGEDHISPDMDVIAQSAPEAFPYEYERNRSPVAVTLEANEVQAAYPQIPQILDTSEPRSGAFRPVSPRGMEPWPREVDQDSMRVPIGKLVPIRAVIRDSTAVVQRAQPTMISHDDSVFDDRTFKPVEVGRSKSFSGGDRRSHPEEPNGYPNGYHDGFIYPRELQQRYQEEREVKAVKPSEYRQEVPLGFDQDDGVKRGTMWKPVEEMTPMERQRRSVGSLDRYSSDERSTRDEEPSRYDDGRQVDNRRRMEDEAQLRRRQDEERANMRRNKQERXSFDERKMRGNRRDMEREGDNRHMMDERGMGGYYQDQERSIGWDKRLMKEMPKRETKQQPEVKLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4V3</accession>
    <name>A0A6P8I4V3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116298257</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562505.1">
        <property type="nucleotide sequence ID" value="XM_031706645.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562506.1">
        <property type="nucleotide sequence ID" value="XM_031706646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4V3"/>
    <dbReference type="GeneID" id="116298257"/>
    <dbReference type="KEGG" id="aten:116298257"/>
    <dbReference type="OrthoDB" id="5961805at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="888"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562506.1"/>
        </source>
    </evidence>
    <sequence length="1177" mass="131941" checksum="1A61563B3E34F079" modified="2020-12-02" version="1">MEVWKIKLFIRICVLCPDLHHLKEEELICLIEECLVVALFLEDVVTQRISYLLLGTLYKQIHQIERAIEYYKKHLHIANEMGDIKGEFTAYERLANAYDLLGDFREAIKHHKKCLNIAEEMGYKIEEGTAYGKLGNDYQSLGEYHKAIEYHEKCLSIGVEIGDRKIESDACCNLGNAYQSLGKYQKAIEYQEKHLGITIEISDTAGKAVAYGNLGIIYRSLGNYQKAIEYQEKSLDIALSIGQRKLEGHAYGNLGNAYQSLGKYQKATEYLDKCLGIATEIGDKEAKRNAYGSLGNICRSQGKYQEAMEHHKKCLSIVIEIGDRRGEGAAYGDIGSTYKSIGKYPEAIDYFKKRLIICKEIGDRQGEESANGNMGTVYHALGKYHEATMYQKNCLSTAIEIGDRQNEIATYSNLGNAYQSLGKYQKAIKYYEKSLKNAKEITLKREEQVAYGNLGTVYQALGKYHEAIKIHKKSLSIAIEIGDRGNEGVSYGNLGHAYYALKKYHEAKDYYEKRLSIAMEIGDREGEGAAYGSIGTIYRFFANYQKAIEYHEKSLNIAIEIGDRPREGNAYGNLGVAYWSLGTYYGQIEYQEKCHGIAKEIGDTEREGVTNGSITRELHSLEKYQEAIEYHKKHLSIAVEIDDRNGQVHAHLSIGTCYAYLAKLQDSDLNINIMMKKAESHLKKSIGTFESLFDDLDQDQYKISIVETYIGCYTALALVYVETQQTDEALLVSDRGRARALGDLLTLKYSMDKETTSKSAFIQVTDIEMFLSTCNFGILFYALFRDELDANIWVLSHQSPPYFHPSKIKGSISNLVEKSYNKLKVREGIKCEDRSLGLPDVEDQDIENERVSSLILDQNTTKEGESDKVDNKTDARCIYDEDHDTDEKPLELLYDELIAPVHHMLVQDEIVIIPDGGLYMVPFAAFQDPKTGQFLSETKRIRLAPSLATLKVLQESSDDEHDRTGALIVGNPKIGQVEFEGSVRSFIDLPGAEDEAKEIAKLFGVEPLIGSQATKEAVLQKLHVGVSVIHFAAHGSEKNGQILLAPSASSLATNSIPDEEDFVLTMKKVQESGIRAQLVVLSCCHSGRGEIKAEGVVGMSRAFLAAGARAVVASLWAIGDNATKEFMLKFYSHLKRGKSASKSLQQAMNNMRETETYMEPKHWAGFFLIGDDVTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I553</accession>
    <name>A0A6P8I553_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116296076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031559890.1">
        <property type="nucleotide sequence ID" value="XM_031704030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I553"/>
    <dbReference type="GeneID" id="116296076"/>
    <dbReference type="KEGG" id="aten:116296076"/>
    <dbReference type="InParanoid" id="A0A6P8I553"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="113"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="563"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559890.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="88201" checksum="4597993C10D3374D" modified="2020-12-02" version="1">MGDDRKRRQTNGGTDGNEVIGERSSSICGPRFMAITGVLTVLLVIAVIHVATSENKKSYFDELLSTGGAIRSARYARSHDEATTIKAGGVCHTKECKKVANYIKSSLNLKSDPCTDFYDYVCGGWKKKNPIPRSSSTYSTFTKLNSQVEKSLREILNAGIKSIEGANKELMKMPSDIYHSCMDLDTIDKVGDKPVKKLIKEMGGWSMDEKNKVWDEKTWDFKKILLYIHKQYTSAGGPLFSVHISDDPVNNSRHVIDIDQAGPSLSREVYFDNKKIIKAYKQFIIDVGTLLGGGKNIEKSAQGIIDFETQLANISVPDADKIESWFHRMTVKELKKEVPEYDWLNHLNTMFTTDKIQESEELTVPALPYLKKLMKLVENTPKSVLSNYLVWNVIQDEVSFLSKPYRDARTKYRDSVLGSKGQKKRWKTCVSYTNELVGDILGAAYIRKHFDKHSKEMAKSMILEVRKAFKDNVNSLPWMDKLTKAAVSEKADAMSDEVGFPTYLIDSKKFIKKFKKYNVVIIKDNALFNNRMAILKMAHQRMLKKLRKPVDREEWPMDPQTINAMYSFNENEMIIPAAILQPPFFYPKGSPISLSFGAIGSILGHEMTHGFDNTGRKFNKKGELTAQWWSSNSLKEFNVKAECIEKQYSHYKVAGKFPINGKLTLGENIADNGGFKSSIKAYNNWLKKNGDETWKLPGLNFTNEQLFYIGFGQAYCSNSRPTEQYLATLSDHHSEEKFRVIGTLSNSYEFSEAFKCKGKSPMNPSIKCSVWSNEGPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I571</accession>
    <name>A0A6P8I571_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Centrosomal protein of 83 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116298681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563068.1">
        <property type="nucleotide sequence ID" value="XM_031707208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I571"/>
    <dbReference type="FunCoup" id="A0A6P8I571">
        <property type="interactions" value="684"/>
    </dbReference>
    <dbReference type="GeneID" id="116298681"/>
    <dbReference type="KEGG" id="aten:116298681"/>
    <dbReference type="InParanoid" id="A0A6P8I571"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 83 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031563068.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="81077" checksum="8C5DDB19A2CBED1E" modified="2020-12-02" version="1">MAEDYNAEMLEKVERMSNLESVVAEQRMRIEKLKTTYETLKIEHLQLQDACQRKDSDIIGAREEAKKVQEECQDIIKRLRSERDSKIQECEELRTQVVTPSKLEMMRIKLLEEIEEPYRERFQLMEAEINNYRSDFNKLRYDYSFLKSEYEHEQTQHKQIVEELQAQYEIDVTSLRKERDALLQKQQQEVPSDAQRARNLQRENTQLHMKLKNLLAELEEIRSQRENAGLQSDHVSRLQARQVSELTAKCKSLETERDSLQQQCKTLQTELEKKHQEQDQLTEEIHQLEKENMSIKSKLEEASHKHKVEISNLRMSLTKNKGDLERERDELQAQIDNCNHKIEVLKRTIDHLKNSLDEKEKEVSKRVQEVKEKEWEKIAQLEQSKLQLETSLAQMERAKLDLDAACQDKMEAMEEKARLATDNKIQMEKECSVLKSQIKENENLANELEREKASYQELKQKHQQLQNHYQSVTSSEQQLMSSNDRLKNSVELLNNELGVARADLQRLHDDHINALEHARQQAEDEKTALEKHISEIENKHKEAEEKSRKGNKILDKKRKKYKQEIFQLQDKIQLLEKKEQQLILERDSEKRKRELEAEKNKRQLEKLSKKQSRFRNMLNNSQPFGGPAPIISSSPLPFNVMPFNVTTEQDRQQRDIALVRERVEELESTQREMSNILQDSLPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6Q4</accession>
    <name>A0A6P8I6Q4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="13">GNT-I</shortName>
            <shortName evidence="13">GlcNAc-T I</shortName>
            <ecNumber evidence="13">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116296777</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031560717.1">
        <property type="nucleotide sequence ID" value="XM_031704857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6Q4"/>
    <dbReference type="GeneID" id="116296777"/>
    <dbReference type="KEGG" id="aten:116296777"/>
    <dbReference type="InParanoid" id="A0A6P8I6Q4"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000252">
        <property type="entry name" value="Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF1">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ILEI/PANDER" evidence="14">
        <location>
            <begin position="121"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031560717.1"/>
        </source>
    </evidence>
    <sequence length="651" mass="75388" checksum="3DABD9BF07161A61" modified="2020-12-02" version="1">MDGRLLRLLLLSAGFLTFTANFFFQLPMRECSTNSKVFPWVKTKWDVGIAGEEKVKISNAIQDEMVYSDQRLDVREGSLNKFLPTKENPVLNIEVYSSRMNVSVTVNNKKIFSANHVNYIGINVVVLNQKTGARMASRNFDTLDSEQDSEDLMKFVEEINVGRILCFIVKDEASYHLKEDTRKYFTKLGSRFINRLRWRDMWAMVIQKKLSGARVLAESFQKCGKEPWASPVDLVTTFISEEESVHCDWGNSETSRRRRKFCSLYEGYHGVCRCSNPYDINMDPPAFPDGSRLHLPVAVMVGNRPHYFFRMLTSLQNVIGLDISMVTVYIDGFFKESASVAELFGMNAVQHEPVSRLNGRIAQHYKRSLSTSFDNNPEAQYLIILEEDLEISVDILNFFQQLLPVLEKDESLFCISAWNDQGYKHSANDPSMTYRIETMPGLGWVLSRKIYKGELEKVWPGPQNLFDWDMWMRGKEQLKGRECIIPDISRTYHFGAKGLNVGMFFQAAYFQQRAFNTIPNVQLNDVNVMLKDNYEKEIHRLISIATLLDHKKTPCSDVKNFVPNTKGKTYLFYITMKHKKDYQTWSNVATCFRIWDLDARGFHNSMFRLWYKKNHIIVVGCPASKYCSFKPDNIVPIDMPKPEKRPKEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I849</accession>
    <name>A0A6P8I849_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Paired box protein Pax-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561242.1">
        <property type="nucleotide sequence ID" value="XM_031705382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I849"/>
    <dbReference type="GeneID" id="116297203"/>
    <dbReference type="KEGG" id="aten:116297203"/>
    <dbReference type="InParanoid" id="A0A6P8I849"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051306">
        <property type="entry name" value="Homeobox_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46123:SF3">
        <property type="entry name" value="DOUBLE HOMEOBOX PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46123">
        <property type="entry name" value="MIX-TYPE HOMEOBOX GENE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031561242.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27821" checksum="B194E99A2858D288" modified="2020-12-02" version="1">MHKKMNNDIGSKSQGVNEGLKVEDSQDAEIKASICRKGYRRKRTAFTQEQLTRLEEEFAVNKYPGIELRDNLAHELNVSEGRIQVWFQNRRSKWRRRQNNVKPQIPNQVSAEPKNTFLGNPTWPCTSLYVKEPLPKPVPSHWLLPNDVITSCEETTCASSASDVPADIRSLLKIRREGHSQQLVACVSSIMSKADEISFDNNESTAHAHNYTDSSLVSYGQMYFGARRSLDEILAAKGLSVLENCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8F1</accession>
    <name>A0A6P8I8F1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein RIC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116299752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564333.1">
        <property type="nucleotide sequence ID" value="XM_031708473.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I8F1">
        <property type="interactions" value="1907"/>
    </dbReference>
    <dbReference type="GeneID" id="116299752"/>
    <dbReference type="KEGG" id="aten:116299752"/>
    <dbReference type="InParanoid" id="A0A6P8I8F1"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="5">
        <location>
            <begin position="806"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="969"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1346"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1156"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1379"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564333.1"/>
        </source>
    </evidence>
    <sequence length="1400" mass="155291" checksum="ACD30A621B036681" modified="2020-12-02" version="1">MYFPIGWPKYYSPKDVECGELSALKYNRDRSLLAVISSHSVCVWNNRPRVLIVTIRRSPSSLKEVGTXVAVAWRPDSSVIAVSTSEGKIVLLELQRSSEQQLYKSQILSSSNHYQSPYQNGVPAIKLVEISIITITGDVTCFAPRKDELFVCSGKGFLHRITWDGYLESSYSMPVHSIPFTNDLQNIRAVPLELEGVCFRAMEYSPLLGGFAVVLADGRGGFVSAETSNFEPAEMIGVWARDLDSATCVAINHRYRLIVFGCTNGASLVYGFDDTTGALELSHTLVLSSKDYPDAIQSTGGVQCLAWTPDGCALAVSWSWTSHGGLAVWSVFGSLLMCTLGGDYGNSQEAFLHNPFHVKSMGWGPEGYNLVMVSSEEDNGCTGDIMQLQFVKSTLAVNPCMSNHRHLFLQSEDSLYLNTGEMVSDCTNNFRNTSKNGTTTSIGSSDENGTTPLIGSSVGPSTLVSNKQWIIIQIPVNYLENNWPIRYAAVHPTGSHVAIAGKAGIAHYALLTRKWKLFGNISQEQTIICRGGLAWWKDFIVVPXYNSHSSSDEVRFYPRTSNLDNAFAVSVKLPAPAFLVNVFRDLLLVYCSDCRVVFYSLERIKTSSSDASILVSRLQEFSLANHVPHPLAVIHVTLTSQYSESGNLDGLEAXESLIANVGGWLLMLQKDKASPEKDKKSKKAPFCLPVILASCVENIWTSTTSSVNKRHLMEALWLGCGAQGMKVWLPLFPGNDQKPPNFLSKRVMLPFQLNIYPLAVLFQDAVVLGAANEPMPLDCMSPNPASLSPQPFPFCTLERTTQVYLHHVLRQLLRKNLGQQALEIANTCTDLPYFPHVLELMLHEVLEEEATASEPIPDPMLPQVVRFIQEFRQYLETVVHCARKTEVALWSYLFSAVGNPRDLFKECLSSGRLQTAASYLIILQNLEHPTVSKQHATILLDKALELCQWETSKDLVRFLRCISEGELDSPPRTPTCRPLHSPPHPTMTTVDDEDMAFSFSVSPQSRGSKPTTRGTLSRGSSVDKTHSARTQSLEKTPKPSSHDSVSRSKSGSVSSADARSSCDVDSAENYFIDSILNRHARLLLSXNRLRDLGRFSAHVDFQIVPWLVKERNRAARVEGYVQTLLFVHRQFDLQLPSITQPTITVQSPQSHQPGPRISRLASASSSSTRSSRQGLDDDALVDDIEEGHEIEETAHLHPPRVEEIDRLSATQSETSSLACSADEEYVWGGQEIGFIDIAQIREQLAFSGCQQSLKEVRFLLKIFIEASCYDWWFLLALVLRDANSIAECINKAITLKDVTTEALSRLNEGIKALEAWSERECIGYSLFLSLQKPQFQTVADAITAXKAKTPERKDSNPTVEPARQTPRTSTSEXDKIIEEKDEVGNDEEKEEEESSECVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9X1</accession>
    <name>A0A6P8I9X1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116299454</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="RefSeq" id="XP_031563976.1">
        <property type="nucleotide sequence ID" value="XM_031708116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9X1"/>
    <dbReference type="GeneID" id="116299454"/>
    <dbReference type="KEGG" id="aten:116299454"/>
    <dbReference type="InParanoid" id="A0A6P8I9X1"/>
    <dbReference type="OrthoDB" id="330637at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23462">
        <property type="entry name" value="beta-trefoil_Ricin_Pgant9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000047">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF101">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="462"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031563976.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="69704" checksum="4B32687A2D2CC8CC" modified="2020-12-02" version="1">MSYTRFVRQQRLLVKVFILTSVFWISVDFLIFLTFMNNQLNLFDSENLMPNTVKNNRRSHDYRKFLHKLRSNSNRKNRYEAFDVIPGLGEFGVPAKLPDNLKNAAQMVFDNHSFNVMLSDRISLDRKLQDVRGPKCKKKHVGYPKKLPTTSVIICFHNEALSVLLRTVHSVLNESPPHLIADIILVDDFSEYDNLKEPLMQHISRLKKVKVLRMPSRQGLVPARLRGAEEAKGEVLTFLDSHCEATPGWLEPLLARIAEDKRNVVCPVIEVIGADDFSYQTSDVIFERGGFTWDLFFTWKAIPEVERLRRKDETDSIRSPTMAGGLFSMHRQYFYDLGTYDDEMEIWGGENLELSFRIWMCGGQLEIIPCSRVGHVFRKFTSPYKFPKGTSLTLAKNFNRLAEVWMDEYKELYYRKKTEEEKAVDIGDISDRVALRKRLNCKSFKWYLENVFPDMTSVDPNPPAQGEIRNLYNNICIDTLGDKNKIEKVGLYSCHGMGGNQFFTLTKSNEIVFGDDKCLDAPDGEPGSFVQMITCHGLRGNQEWKHNKQDETIVHVWTENCLDLSEDRAHIVVNPCDGSKTQTWRFSRYKKDNNHTKTPEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA33</accession>
    <name>A0A6P8IA33_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tether containing UBX domain for GLUT4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564021.1">
        <property type="nucleotide sequence ID" value="XM_031708161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IA33"/>
    <dbReference type="FunCoup" id="A0A6P8IA33">
        <property type="interactions" value="1798"/>
    </dbReference>
    <dbReference type="GeneID" id="116299499"/>
    <dbReference type="KEGG" id="aten:116299499"/>
    <dbReference type="InParanoid" id="A0A6P8IA33"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16118">
        <property type="entry name" value="UBX2_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="361"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564021.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="58970" checksum="7A71F810FA20F958" modified="2020-12-02" version="1">MATCKSVVVVCPNARRQTVKVGPTTTILQILEEVCKKQGFSSQEHGIKHQRKILDETLPIRYSGLSNNAHLELVKHVKTSKQGVQCTIAIQLASGERLQNDFPPENSLWDLVSHWNSQEGSEHQNKLFGTEEQDVVCVYMTQRISGEDNLKKTTLHSLGLTGKRAIIRLLHEKASVETSEPMISEDKTSLKKQETSAENPQPTIPVTVPTPNTGNYCQPLSSGDKEIADLDRHRPLDTGTVSPERAASDPKRTRVTGPTPLFPDFKFPERPASEDQGQISMTEERLQQLSTPCERCPVIFNEDDQTLSNASEEDVPDSFYDVTVEDLRKMLQDLHSEKTKGAEMPLLTKAMRESRRLQEMYKYEKVVIRVKFPDRLTLQGFFRPQEKVSVLTEFVKSHLEDPDTAFYLYTTPPKTVLKNQEATLFASQLCPASLVYFGSSMKRDHFLSSTLIGNLKSALDAEKTVFEAGIRGPAEPQSTNTEHLSNTTANSTNGRPVGDVTSSARQAAQPTQAAAGSNAKVPKWFKGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB15</accession>
    <name>A0A6P8IB15_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116298267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562517.1">
        <property type="nucleotide sequence ID" value="XM_031706657.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IB15">
        <property type="interactions" value="1780"/>
    </dbReference>
    <dbReference type="GeneID" id="116298267"/>
    <dbReference type="KEGG" id="aten:116298267"/>
    <dbReference type="InParanoid" id="A0A6P8IB15"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031562517.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32736" checksum="308CFB8EF4CF60A9" modified="2020-12-02" version="1">MTGNIELLSVLEGHEDRVWCVAWNPTGTVLASSSGDKTIRIWGKEGDKWMCKTILEDGHQRTIRSIAWSPCGTYLASASFDATTCIWDKKSGEFECNATLEGHENEVKSVDWSKSGSLLATCGRDKSVWIWDGKRDRKPLICFDTLEGHESTXWSISFNAKGDRLVSASDDKTLRIWQSYPPGNQEGVVTAGKDPKMKCVCVLSGYHNRTVYDVDWSKVNGLIASAAGDDCIRIFQEDINSNRNQPSFTIAAMKNKAHEQDVNSIKWNPKDGNILASCSDDGTVKIWKYVSDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICI9</accession>
    <name>A0A6P8ICI9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116298990</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563452.1">
        <property type="nucleotide sequence ID" value="XM_031707592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298990"/>
    <dbReference type="KEGG" id="aten:116298990"/>
    <dbReference type="InParanoid" id="A0A6P8ICI9"/>
    <dbReference type="OrthoDB" id="5990016at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051792">
        <property type="entry name" value="GGT_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43199">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43199:SF1">
        <property type="entry name" value="GLUTATHIONE HYDROLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028041387" evidence="5">
        <location>
            <begin position="21"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031563452.1"/>
        </source>
    </evidence>
    <sequence length="887" mass="100139" checksum="C7E06DCE0D6D9BB8" modified="2020-12-02" version="1">MDFIQILMLYLVTVIEISTGNIPRENISLSPSTWPQEEYLRLETIXLRKNPRPKPLAYSDTKGLVAGTTSALAVHAGIDALRKGGNAMDACLATAMAEIPLTAGATVSFAGVANILYYDHVTGRVHNLDSGWKIPRNRNQEQIPSLETLGDSVLVPGFLAGMFEAAEFSKFPLSTLLEPALFFAEQGLKVPHSLSKLMKQYYNRHTLLKTDKGSKIFTNPQTNKPYEPADLFRQPQLAKFIRNIQRHGKNYFYRGKWTKKLLGTVRKHGGYMNANDMAHYEAQWIEPARTMYNAYHVFTTGADWGGVELLEMLNIMNLAGLTLSNDTYLTNATKLLSLISISRYSQFISAYSHANPEAWGTLHEYFHIDSSRKGRMSNATAKLIWNRLSNQEGFDMISELIHELLTSVPDVDRHRENRRGSSGIXAMDKEGNVCSMAHTANSKPWGTGLFVQGVALPHSGAVLRDMVSRGQPGSRVPSGLQPVIVFKKNTNKKSTSXSFSKGTLXRIEKPYKREKNQEILEINSXIIKKEISAPKQKSAVKQPKELLSDTLKKNSKKGYLSIVNLIRGQDSSEKPHGIDGGNHKPNPTSGHEMSTMEVINSSVVDTNKTENQEADNIEEGVNEKNDSKKTEVKNEWEREWKNHWEYELEENEKENELKYDKWKENEWENKIEREPLESEEXENKNQNGNELTDSKYEEEPETIGGLFDINELNSDYGKDTSTKTASKISSSQYAVKKWFRNFVQKLLQQENNKLPTGLITRKNYKKKRRNRQLKPAAALSVXGQSATEAILQYINNLLDNEMDAKQASETPMFFSSTPGSLRQDVRLERFSFDQDVINDVRSRGQNVREVMHKVSRVIAGFGAVLTVKXKRIYGCSHPDSEGFAEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID23</accession>
    <name>A0A6P8ID23_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Endoribonuclease Dicer-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116299351</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031563857.1">
        <property type="nucleotide sequence ID" value="XM_031707997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299351"/>
    <dbReference type="KEGG" id="aten:116299351"/>
    <dbReference type="InParanoid" id="A0A6P8ID23"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000004">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="19">
        <location>
            <begin position="569"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="18">
        <location>
            <begin position="924"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1244"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1474"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="879"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1114"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1132"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031563857.1"/>
        </source>
    </evidence>
    <sequence length="1739" mass="195640" checksum="17D3AD73CE48DB57" modified="2020-12-02" version="1">MESKRAAEQSFLRPPFPVDLVETGLRQKKSLLCVAKAKSKFFIAVKLVEEVKRRSSPGKTALVLSENIEGDFVKEFSRAVDLQTDLKRISLEDVRNKTASDSLDANVLVTTIQGTVDLFESNILSVEKVNLVIIDDCLIENDVVIFDRDEVYFYLPPFLSVIELLTSHEQMPQPIIIGLLSDLPVSSPEKIESMLPATELAFGCSFSVSSDLVAMNRFGEQPQEKLIKCSVLADEAEKVKQIFTIVMSTLSNFLLIHEESQLVRIRRQCVLCYKILGHFGCYAAIYHARLIMREISKLKKKVSELEKPHLLRCETQLQSLLQYSKKDEIPDITPLVKNILTSLSYLKPKSTSGSKTTYLSTSNENDDTASSFKVASNTNEGRHGDNPVSIILCFLDQEAMVLNLLLNTLAKTNPEMAFLRSRHISSAMIKPNDMSTDXDTDERINEDIIRLICDGQVNIVVTSPDMENDIYLGQCKQVIRIGIPQDYLSYVRVKNIPRMAHAQFIILESEDKDNGNSMLRYNAFKQTEGILTTRCSSHQTVPKPDVLSLDLADCSLNGEDRPCIDANDAIALINRYCKAFPSDGFGCAVPRCREKLIKEKDQTRVVSKLYLPRHSPVFWSFKGTATIPRKQSKRPATPEELAKARIESKTRAALLACQALLDVDEMNDQLEPTIRHTNVSLKKADEKCDGEVADGGQGVEGSAKRRRAYHKKFATVLTKNLAVAEEPVYVYSITVAVNKLARHEGKVRSYNVPSTDVSSVSLGFLSRNRLPKLPNFVLFSKAGELKVSITECLSTTTLSPEQLALVQRFHQYVYAHIININGENEEQCFRFDPEEQSFGCYLVLLSGLSVDPEPSSVKYSSESMKEVKEGTEYDLTLQSCKERTNDESETQRSSTEELGNTLRADTQDTAHENRAENLTIAFDFLEDLEKQLGDFRNPQHPSVTETRNYEIFRNRVVTATYMAKPTSYFVADICYDMTPLSPFPDPSVAATFAEYYKERYDVVLREDQPLLTMDCISKRQLNLLSSRYQDTKGKNLALPDKNSKRSQRSKINLIPQLCSIHPISASLWQQMLYIPSIMYRLECLLVAEELRHTIALQTGIGSIEYPGDDLPLLATGESVGENSTEGLFEESNSERSKQEQTEVPKDRPEPSRKKETEVPKDRPDSSRKEQTEVPKDRPEPSKKEETEVPKDRPDSSRKEQIEVPKDQPEPSRKEETEVPKDRPEPSRNGQAEVPKNRPGPSATLFLRALTCLGACDVFSHERLEMYGDALIKHSVSLNLYHECPFSNVGQISFLRGLHVSNRQLFYLGRALDLPSYICNVPFKPLVNWHPHGFTALSCAKTQARYLELNAAEQGIDLSDNEDEKSEKDEAACVKPGQAALIDGQNHVVVSDKTVADATEAIIGAYLVTCGFNDALRLMKWIGLDVRTKKPQENISSTSTMSTPEYVDEQETSDFDEEFFDNSLRLSKESLDVEFKEIEEVLGYTFRDKLLLLQAFTHASYPRDFIHVRTSYEHLELLGDAVLDYLITRYLYYTQRTMAPGALTDLRSAVVNSYSFAFLAVKYGFHRHLRSLSPAVFKLVNKFVVVQDGMMKKEMKENPDQIFSSVFIPMDDEAGEGVEVPKVLADLFESVIGAVFIDCGQDEEKTWDVVYPLLQATLEHYSIHLPVSPVRQLQEMLPSSVSLLSMDRSVAGKYTCTLLVQGIGKFKGTGRKPKIARSTAAQRALAHIQSQSGKASTKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDC1</accession>
    <name>A0A6P8IDC1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dCMP deaminase</fullName>
            <ecNumber evidence="6">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116299602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031564137.1">
        <property type="nucleotide sequence ID" value="XM_031708277.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IDC1">
        <property type="interactions" value="1239"/>
    </dbReference>
    <dbReference type="GeneID" id="116299602"/>
    <dbReference type="KEGG" id="aten:116299602"/>
    <dbReference type="InParanoid" id="A0A6P8IDC1"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="214"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031564137.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43046" checksum="FFBB7D531FB492DF" modified="2020-12-02" version="1">MTTTDKERVVGAVFVQPNXRVLSVDCSRSNDDGIVHGAIRALLKYPDQVEGCYVYLSRQPCAHCVKMLVQAAVKKVFYLPLKPERKDEQEENKSVDALFKVSPVSREVYVPNITKGDLDELASANKKNLYGKRKLEKDESVALKVEWDEEWKKEIAAKIGWDEYSDAEIKKQVDVEMQNFFEWFDKGILETGEKEMNFKVRGSKTTQGPDVTQKVANHLSRLAQMLSNRTDDPNRGVGCVIIIDEEIVAIGWNGFPAKALYGNHPRQGKSAVGGRDKYPHIIHAEQNALMRRNRRKLNDATAFVNKIPCNECLPMLCDAGVKALYLSKDAFKKKNETTETSFYELLENPENDLTVYEQIIKDKYYMVSEVDKKLWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IET0</accession>
    <name>A0A6P8IET0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300067</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564690.1">
        <property type="nucleotide sequence ID" value="XM_031708830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IET0"/>
    <dbReference type="GeneID" id="116300067"/>
    <dbReference type="KEGG" id="aten:116300067"/>
    <dbReference type="InParanoid" id="A0A6P8IET0"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08557">
        <property type="entry name" value="PI-PLCc_bacteria_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027984710" evidence="1">
        <location>
            <begin position="26"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564690.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40524" checksum="8D46F3FDD467F83E" modified="2020-12-02" version="1">MSISIFIRIIIVTFCCLPLFDSVVSGTMKCNGMEELCELRLNQVTLPGTHNSGSGFNGHLYHWGGGIAGSSLWRNQQWSFTRQLDYGIRYFDIDTCYVDKEYSDWWTKGAWACHMGMGTAAYAGPVKKILQQINDWLNKPEHLNEVVVIKFGRDVEVDFKPERIYKSILADLKNLGWKPTPSTKSAKSLTANAEFGKNYQWPKLRDAINTNQRVFLFFSEKLMKFSKPSEFRGTPWIITAEREVKITWPDVGGDCSGVVDKIVKNCKKFKRHGGLLELDVFGFSVTVSTWAMQGKCDKYMQKSMDECFAVTKKYHKTVNAVLADWVDRSKSPNTVLDVARKQNERNIAMFKINGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFF0</accession>
    <name>A0A6P8IFF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116300694</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565470.1">
        <property type="nucleotide sequence ID" value="XM_031709610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFF0"/>
    <dbReference type="FunCoup" id="A0A6P8IFF0">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="GeneID" id="116300694"/>
    <dbReference type="KEGG" id="aten:116300694"/>
    <dbReference type="InParanoid" id="A0A6P8IFF0"/>
    <dbReference type="OrthoDB" id="10035013at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026828">
        <property type="entry name" value="SAPC2_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057953">
        <property type="entry name" value="SAPC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907">
        <property type="entry name" value="FI14130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14907:SF2">
        <property type="entry name" value="SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25825">
        <property type="entry name" value="SAPC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor APC" evidence="2">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565470.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43008" checksum="E7CDFE5217ED13A1" modified="2020-12-02" version="1">MKSSIAEAENSCFFHPEDRNGCPGSISESLLDVDTKKELPKEFANYLRSLFDILDQDHCGYIKLTDIENYWDVKGPSFSAMIDYLRQCSPDNGLINFDTLCTGLKFVVHTPNITSHSIQKDHDWTSDSSEDSFRLHDFETKEQLLRKLQPKLVPEEPKDTSLMVNATKTTLASNQTGSTSKVYFVAKELSSSTAQHEQDGLRGGGTNTVLARERIDMKIRSNQVEEELQVLKEGLNVIEKARKWYFKRFTAVQEENLLLQQSDKNSLEQFQYEMLLHKTRRKELNLNETVFKCYKKNIQELNKYMKELIENPHELLNISNSMDECSSTREQLQQLNHDLLEKNSRIAQLEKEKSVLIRDLFQAKAAAGLGNVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFH2</accession>
    <name>A0A6P8IFH2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin-J heavy chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565490.1">
        <property type="nucleotide sequence ID" value="XM_031709630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFH2"/>
    <dbReference type="GeneID" id="116300713"/>
    <dbReference type="KEGG" id="aten:116300713"/>
    <dbReference type="InParanoid" id="A0A6P8IFH2"/>
    <dbReference type="OrthoDB" id="10501030at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565490.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="60574" checksum="B073C258E9B29E43" modified="2020-12-02" version="1">MVQREVEVLQKLSDAHKVIEELQAEKGGIEEELIRNRMEKTGTVKRYEEKIKKMCETLKLQSDQEKDLRHVIDSLRKQTEALEDEKENVIQEGSKVVESLNMELEVQSRREMELKEQLGFFEDEINQLRNELDDRAKREAELREEKSLEIQKIRLENDSMSESLRTKISEMNGELMKHITKENDLRVQVESARVEKEKLLLELEELNNDKSSSTRTSRKLISELRKSENELLEKIDELNLTVKTLEGEKRRISMEYNDYQSDILNITQTSRDANKRMHEDIKILRDNNNNLHAQLRELKLNESCLLRDKLEDREGELKNEIIELRSKISAAEDKRVRDKAEYKSRENSMVFEAKVANSKIEDLHIEKKDQEIKRLDRSSEELRAQILRLQQEKQQISDSLDGCKTFLSHRNAEVHILEGKLSDQEALLTTCKRHNVELTNLRNEMMTNSMILGSRLDLIRVRQIQERNAQELKDSKKPWDKNSSNRQYLENRGSNNITPNIQTSSYENSSTLTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGE3</accession>
    <name>A0A6P8IGE3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300941</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565775.1">
        <property type="nucleotide sequence ID" value="XM_031709915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGE3"/>
    <dbReference type="GeneID" id="116300941"/>
    <dbReference type="KEGG" id="aten:116300941"/>
    <dbReference type="InParanoid" id="A0A6P8IGE3"/>
    <dbReference type="OrthoDB" id="10001248at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027813501" evidence="1">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565775.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23518" checksum="7DE7139D26080EEE" modified="2020-12-02" version="1">MKSIMVILVLVAFVKAKPCQVPRRLSGDFNVFTFNVDEGKVVSIIEGTTYIDQEHKRIRIEGHFGETNKYKVIQLFDERIQYVISEGHCRTMPVTGEFKDMNIPANASIVDKGRIGPASDGLNIFRYAEISAEGKYLETVTQKDCITTSKVGVVKVEGVHYVVYLSFTGASLDFDDAVFDVPSECREVPARSRRSVEWFLNNLKHFIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGL1</accession>
    <name>A0A6P8IGL1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116301016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116301016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565874.1">
        <property type="nucleotide sequence ID" value="XM_031710014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGL1"/>
    <dbReference type="GeneID" id="116301016"/>
    <dbReference type="KEGG" id="aten:116301016"/>
    <dbReference type="InParanoid" id="A0A6P8IGL1"/>
    <dbReference type="OrthoDB" id="10308958at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031565874.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34360" checksum="E2A40BAF6BA13C67" modified="2020-12-02" version="1">MSVTALQLEDRVPKHQPFSIYLDEALKTLNSEHTPRTIPQRYFKQGYTNRTSELGQKCPNRGRAHKNLGSKLPPDRSMVATKGTQLFPDGGIVGQNAIPDKGMIGTKVIKRRVARVEKEKKIVSERLKTEKEFSFKKSSKMTNVQPLGKLREYRNDYSIDHIPSLKKVDVDDRYEKEKHIQKVLNRLNLNAGPHYKSPTSSSSQKGPVIKNTTGIDFASSLMESHNLTLKQLREFWQDMPSFLNIQAAKLRRKYGIVGSEAADDIDDIAIEIVTKWNTPTTVVLPNIENQISRTLYVVEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGM3</accession>
    <name>A0A6P8IGM3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase notum2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pectinacetylesterase family. Notum subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565813.1">
        <property type="nucleotide sequence ID" value="XM_031709953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGM3"/>
    <dbReference type="GeneID" id="116300968"/>
    <dbReference type="KEGG" id="aten:116300968"/>
    <dbReference type="InParanoid" id="A0A6P8IGM3"/>
    <dbReference type="OrthoDB" id="2015280at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562">
        <property type="entry name" value="NOTUM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562:SF122">
        <property type="entry name" value="PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565813.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39052" checksum="439EA07E28B3D059" modified="2020-12-02" version="1">MTGTFLSSDDPNENPTFASWNKVYVPYCSGDVFVGRRPKSTHPYGLQMLGHYIIKAVMEQLMADHHINSTENTILFGGASAGGLGMLANLDYVQNMLSPAKVRGFNDGGWFTLFPNFGEELAQGTPYFFSTLEVMFNRLWDGYVDESCRSEMPKPAACLYGELVVKYLSTPIYVMVAQWDSYQLQELVPSKFPTVRLPPELPSEAEYLSKFGNNTHRSLRRLILSDKSGVFSPACFMHTFSGESDYLAVTSKYQIKGRTAYKAFSEWHVSSGREGTYVETPLETPLCNPSCCSSLCTKCREHQTTTTTKRSYKRSDYAVRASSTGLSTIYCTWLVIWGFILHMLLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGQ8</accession>
    <name>A0A6P8IGQ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor SOX-21-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116301007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565860.1">
        <property type="nucleotide sequence ID" value="XM_031710000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGQ8"/>
    <dbReference type="GeneID" id="116301007"/>
    <dbReference type="KEGG" id="aten:116301007"/>
    <dbReference type="InParanoid" id="A0A6P8IGQ8"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22004">
        <property type="entry name" value="HMG-box_SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565860.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="42454" checksum="B45A5C36B82094F0" modified="2020-12-02" version="1">MWYPTFGSWGAMNGTSVGLQNYDDDEDSHVKRPMNSFMIWAKVMRRKFAEENPKLHNAEISKLLGKSWNELTTKEKRPFVEKAERLRIRHMKEHPNYRYTPKRKGRQERRNGQRTLSSFIAPTFMNGVSNIMGPNHNIHLPLTPEPSPTEPLAAEDHYYSETSQYYPYNAVNTGEYGPARRAHTPESYFTSQQRKMESSIGYQYYNEHEYPYSGHSRVDENRELYSQYYAKQNLQNEAFRARNSEDHNKDSKSWRATFSESLASNQEPPYTRPSCIKDSYTARYGPYNAMNNTLRRQHDAFQHHTSRSSCRFSSVTSENGTEDGDGRTRRQENSGGAPVFEQLSDLLCDDLDRNEFDMYLKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHE5</accession>
    <name>A0A6P8IHE5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tachykinin-like peptides receptor 86C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566048.1">
        <property type="nucleotide sequence ID" value="XM_031710188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHE5"/>
    <dbReference type="FunCoup" id="A0A6P8IHE5">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="GeneID" id="116301166"/>
    <dbReference type="KEGG" id="aten:116301166"/>
    <dbReference type="InParanoid" id="A0A6P8IHE5"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566048.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33767" checksum="717AB16155560537" modified="2020-12-02" version="1">MYQLQDIVYSVLFSVVLVFNISGNSLVIYIITNEREMKTSTNYLLLNLAVADLLFGVFLAPEFIFLPFFRHSVPDGVLGDWLCKLLLTSNIAWMACRASIFTMICLSVERYFAVCRPHTFRQRFSPKIVKVLVVVSWMYAVVVLSPFFVLNHLNREYLYCVINVTTRKVYAVYIFLEITCSLSLMIFFSVKIFLSLWCQQTVEPTGEREITERKKKKKVTWCVLAVVVTFVVCWIPAAAHYIIHGLSNTPFEAVDIATTLVASFNAALDPYLFSFQSSRFKVLVKKVVCCGKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIH6</accession>
    <name>A0A6P8IIH6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116301430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031566343.1">
        <property type="nucleotide sequence ID" value="XM_031710483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIH6"/>
    <dbReference type="FunCoup" id="A0A6P8IIH6">
        <property type="interactions" value="1083"/>
    </dbReference>
    <dbReference type="GeneID" id="116301430"/>
    <dbReference type="KEGG" id="aten:116301430"/>
    <dbReference type="InParanoid" id="A0A6P8IIH6"/>
    <dbReference type="OrthoDB" id="6021732at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000043">
        <property type="entry name" value="acylamino-acid-releasing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="509"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031566343.1"/>
        </source>
    </evidence>
    <sequence length="719" mass="80561" checksum="BFC73D292475949A" modified="2020-12-02" version="1">MAETEQAIPDQGFIDHATQIYKELSSIPTITGGSLYTKKNGKDNEAFEFVVTSKWSQRDLEKKEKRVFQRNHIATFSGDSRKLISVQEPSFPVELQNVQLSSTSPSGKYQAIIRKIPATKKDDEKQFIEIWSCNNIIKSIDIKAADKHGDINEDSQFGSLQWSPSEKYLLYVAEKKKPKKVSYFDSSKSEESSEKSKPETGFQFDYESDWGELLVKKSHPILTVLDIHKGDISVIDGIPDDLSVGQAIWNPGETGVVFSGWKHEPYRLGLIYCTNRRSGIFHISLDGTNFEQLSLPDNAVLSPRFNPQMDKLIYLARNTKGVHACCLKLMEFDWKARTTVTIVDIVDYPRDDGFAGIYCSGLPERCWSFDGKRIILGSFWASSLKILAIDVESKSVMNLTKEDGCWNVLDVQKDLILASFSSPSCPNRLLIRPLTSSGDGADLDWTVIANMEDHQDIKWENITLSPDGDKTKSYEAVLIQPTNLEKDVQLVVHPHGGPHSNYPSNYMIEFAGLCKLGFAVLSVNYRGSLGFGQKVLESLLGNVGTQDVGEVKYALDKVLETRKFDKKNVFVMGGSHGGFIACHFIGQYPDFFSAVAIRNPVINIVSLIGTSDIPDWGFEEAACDFDDDLLADAETYAKLLSHSPISHVKKIVTPTMLMLGEVDLRVPPSQGKELYRTLKARGVDVRLLIYPDNSHPLNKVEAESDAFVNISRWFNKHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIP5</accession>
    <name>A0A6P8IIP5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TNF receptor-associated factor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116301755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566731.1">
        <property type="nucleotide sequence ID" value="XM_031710871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIP5"/>
    <dbReference type="GeneID" id="116301755"/>
    <dbReference type="KEGG" id="aten:116301755"/>
    <dbReference type="InParanoid" id="A0A6P8IIP5"/>
    <dbReference type="OrthoDB" id="5574452at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00270">
        <property type="entry name" value="MATH_TRAF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000007">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000286">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012227">
        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF148">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015614">
        <property type="entry name" value="TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="10">
        <location>
            <begin position="127"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="9">
        <location>
            <begin position="218"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="127"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566731.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42333" checksum="FA71C204F15AC684" modified="2020-12-02" version="1">MASVSAVVPQATALFNGNLPPLNKSQAGGFDADFVTPVHIDYQCPICQLPFREPVQTRDCGHRFCESCLEPILRKPPSLCPIDRRTISRDKVYPDKACKRTVLSLSVRCYNSGTDCFWSGELGNLAAHLEACKHVPIKCINNCGKTDIAREEMAAHIDVDGDCPLAIVPCKYHDIGCKIKVKRSDMDKHLEDCMPSHLDMAHIRIKELEQRQEKVCTNGKFLWKISNYYQLYQQSATKKDKEKLCSPPFYSGQYGYKLRAEAFLNGLGQGKGTHLSLYVVIMKGDYDAVLPWPFQQRVDFILIDQDDDFNNRQNKPWRLTCDRNSDYFGKPNKAKSLGFGCPKFVSQETLKTRNYIRDNTVFIMIEVEPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJA8</accession>
    <name>A0A6P8IJA8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301823</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566810.1">
        <property type="nucleotide sequence ID" value="XM_031710950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJA8"/>
    <dbReference type="GeneID" id="116301823"/>
    <dbReference type="KEGG" id="aten:116301823"/>
    <dbReference type="InParanoid" id="A0A6P8IJA8"/>
    <dbReference type="OrthoDB" id="5957937at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566810.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16616" checksum="25224934F01C2B8C" modified="2020-12-02" version="1">MEKEKEEGNIGDSSDNEKQSSVEHDSLREFVTKECLQQLQSNGHVSDNSIEQERMNQFFQRAISESERMNAEVSKSRTQQQKLYEELGKDMFESWSKDHASEVLTPEQYQSWKNEEEKLSKDFMRKKMLHNKVNDEDSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJR6</accession>
    <name>A0A6P8IJR6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibroblast growth factor 22-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566965.1">
        <property type="nucleotide sequence ID" value="XM_031711105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJR6"/>
    <dbReference type="GeneID" id="116301931"/>
    <dbReference type="KEGG" id="aten:116301931"/>
    <dbReference type="InParanoid" id="A0A6P8IJR6"/>
    <dbReference type="OrthoDB" id="5987799at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00058">
        <property type="entry name" value="beta-trefoil_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056378">
        <property type="entry name" value="Let-756-like_FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566965.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26131" checksum="22A3339F5C5736DB" modified="2020-12-02" version="1">MGEDNQARDQRRINKENQDHRVGQKRRLDFTCHSAWWTQIFNANKLVIILFLYLTLPNWIPTSTALQASSTYSGQRKASQKNYSLFSLTKVPTNAQQMRLFCRVGLFLSMNRNGTVSGVLQKNGTQEIFELQSFGTSIVRIKHKVTGLFVAMNNKGKVKGQRNAVSSKDLYFYLNHEENAFVSFASFYHKKKKKSLEMFLGIKRGGEVKNGKQTSTGQDSIEFLSLDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKV9</accession>
    <name>A0A6P8IKV9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adenosine receptor A3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116302453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567601.1">
        <property type="nucleotide sequence ID" value="XM_031711741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKV9"/>
    <dbReference type="FunCoup" id="A0A6P8IKV9">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="GeneID" id="116302453"/>
    <dbReference type="KEGG" id="aten:116302453"/>
    <dbReference type="InParanoid" id="A0A6P8IKV9"/>
    <dbReference type="OrthoDB" id="5971811at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="38"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031567601.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37254" checksum="BEBB855A7EEE7FF0" modified="2020-12-02" version="1">MTQTNRSLNETSSNFVDKERGIFWCTSFGLVGLLIFSSNFATITTFVVNKQLRRHGIYCLLNLAVADMLLGALTIPYYINDIAGIFLQWNLLEPQVYVVVRGFYITVLFGSLFCLVVVSLNRVFATYLPFRYRTMKLRSHLSIFAITWALAIAASVVFFLMKQLQDQVVLVFQGLFVMALIIIIMSYVIILMKVKIKNQVPTTSLSQLRERHLAITVFLVSLLSMTTWIPSIVFHAIYKTQTSGFNIDLQLSIYLIHSSNSLVNPVIYVFRMKDFRKALWKLFTSCMPADSSITPPTSPGNVESNNNQGAGQTNKCVLSFNNVVFDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILA2</accession>
    <name>A0A6P8ILA2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116302409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567557.1">
        <property type="nucleotide sequence ID" value="XM_031711697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILA2"/>
    <dbReference type="GeneID" id="116302409"/>
    <dbReference type="KEGG" id="aten:116302409"/>
    <dbReference type="InParanoid" id="A0A6P8ILA2"/>
    <dbReference type="OrthoDB" id="10303583at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="2">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567557.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17991" checksum="59D1C65E9E0DCA57" modified="2020-12-02" version="1">MLIQNSTFFSESRKHKLKMNIQKSLLTILLFLFIVVEGNCLWCYECLSNISWLDCHRHMFKRKCNFSEKFCLKATRYADDKGNPEKTMVKLCTEKELCSGYECKKYNVECEVNCCDTDFCNGTGLLPRMNVFFIAMIVINTVFINTLRMFPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMA7</accession>
    <name>A0A6P8IMA7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031567932.1">
        <property type="nucleotide sequence ID" value="XM_031712072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMA7"/>
    <dbReference type="FunCoup" id="A0A6P8IMA7">
        <property type="interactions" value="2480"/>
    </dbReference>
    <dbReference type="GeneID" id="116302708"/>
    <dbReference type="KEGG" id="aten:116302708"/>
    <dbReference type="InParanoid" id="A0A6P8IMA7"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045:SF0">
        <property type="entry name" value="7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031567932.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37691" checksum="F681826905A4CD06" modified="2020-12-02" version="1">MSRSKEEIAMFAVAAVGVSAVAGYGVYRYICSRNERLRVKKATDEMVKALDKTNVYLRDSIGVREKLQRMYEAGTEKLQIVSDFDKTLTKFKVNGLQGCTVHGVLETSKHFPESYREKALELKDKYHPIELSDMSSEEKGPLMEEWWSKAHDLIKELNLRKENLPVIVKEANIALRDGVDWLFVKSHEKSVPILILSGGLGDIIKVVIDQGSELYDNIEISANFMKYNDQGVMVGFEGKLISSNNKEERTKDLAFFKKMKSRTNVIVMGDLIQDTDVVKSIQNPENVLTIGFLNEKVDERLKDYENAFDIVIVDDHSIETVDLLLMKLFHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMR5</accession>
    <name>A0A6P8IMR5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116302858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568107.1">
        <property type="nucleotide sequence ID" value="XM_031712247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMR5"/>
    <dbReference type="GeneID" id="116302858"/>
    <dbReference type="KEGG" id="aten:116302858"/>
    <dbReference type="InParanoid" id="A0A6P8IMR5"/>
    <dbReference type="OrthoDB" id="6042561at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028021649" evidence="1">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568107.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26412" checksum="142062D86B3E3D58" modified="2020-12-02" version="1">MKSLVLVVILAAFSDAWLFSSGPNTPKWNSLYVTFGSFNQLPTTKTAAVAAGWRLNKTCDARNYFAGNRYILGGDTAVMLLFGANGQLAGIQMGAARSIVGVKRNPWVREGDMYVMTAYFTDPRTICSRTQTRIYYGDRLLILDGTTNSTIVIPFKEEDLTGSKWVAGKCFPTMGQHYWYDISNNMDCNDFYPVFIMYNGKRLDSFGWNTNGFLKSKRCEHPTSDRFGVSPIKAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPY1</accession>
    <name>A0A6P8IPY1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (34-2'-O)-methyltransferase regulator WDR6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116303083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568393.1">
        <property type="nucleotide sequence ID" value="XM_031712533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPY1"/>
    <dbReference type="FunCoup" id="A0A6P8IPY1">
        <property type="interactions" value="1729"/>
    </dbReference>
    <dbReference type="GeneID" id="116303083"/>
    <dbReference type="KEGG" id="aten:116303083"/>
    <dbReference type="InParanoid" id="A0A6P8IPY1"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027710467" description="tRNA (34-2'-O)-methyltransferase regulator WDR6" evidence="9">
        <location>
            <begin position="17"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="1100"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031568393.1"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132840" checksum="571FA07CB519C83E" modified="2020-12-02" version="1">MWIMMKKTALISSVTSLGFVKDLILSGQGPNLSIYHTVSGEKILSDHVLGNSRIHVIKVNEKEKSLVAISGQKIMRVVEIISTQASVKIENKTSLLSFPDLILDVHWLHGENGKSNAVAIATAHNAVWYFNMETGIRSQVAQCEETSILYSAQFFGKDLNNLLLASGTVFNQVLLWKVKGAETKEKSIKVLSKLCGHEGVIFKINFNKSGTLMTSVSDDRSIRLWKLTHAGLDFTGEVQLLLILYGHSARVWDAKVLTNFLVSIGEDAVCNVWNYDGKLVKTFSGHKGRSIWSLAISKDEHVIATGGGDGSIRLFSLEDINSKESMVTAQAFLPGTAEQLKLNKKGGITVDSPRSVSLVTHKKSLIMTSEGYLYEYTWREKPGNTAKSITRNTLDHQPEGSDSMAEWTSNEWKLLLHDPNYSSYSLMAVSSDHKYVAFGNLQGSIKVQETSFSLDAKEVKPFTSKVLSLLWSVQTASHSLFSCGPEGIIIWWHVFKDSQQVLQMVRVRTFCIPYSKQRWPSAVEVLDQDKMSTKRERKVGNCHIVFGDRKGSLHLFDARRITQHEVLDPVHSLPVIHGRIGVTQLCAHDNSLYSAGRDGTYRQYRLLDSILEVIDTKKVFKGLEWVEKLIFLANGDLVIAGFHTAYFVVWSVERNQPVFKVKCGGGHRAWDFVLNQNPESQNYEAVFTYLKGNSINVHLEQLRNSIAKPVLQTGFHGREATCLCYVDSLPLGKQGFPRHHVFLTGSEDTTINMMSYNSTVDFLTKVFTAQGHISSIRTLSVTRCRLRVQKQEDTGETTIEGTDCSMKYLLFSGGGRASLRCWRVDLSAIKILDNECVASSPPVSHICEYSSRSSNQRRKRRRQLGQNICSEIRFMSLTSLSMSVILDDESFQDKSWYLYGIAAACSDGFVRIFIFDEKNSKFFLLAQSDYLQRCVLTVNHLIHHNFSGRHSVLIFAGDTAGKISVWDITDHLIEYVRDEDAAEEADDAATTNKSDLHREDGNELVQNCTEGHLCCYSLVEEHEKNNFSCITPAENSLGRPIHVFRAHQSGVNDISIHKGCASYVLCSGGDDSGLFVAELNLCSAESGSRGIVVIREETVQSAHTSSVTGIRIIDSSRIVSSSTDQRLKLWNIDSNEDSTTNNKFIRLSKVEFVDVPDVQAIETWETWKENGRCTTIGVCGVGLQMLLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQK1</accession>
    <name>A0A6P8IQK1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569351.1">
        <property type="nucleotide sequence ID" value="XM_031713491.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IQK1">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="GeneID" id="116303882"/>
    <dbReference type="KEGG" id="aten:116303882"/>
    <dbReference type="InParanoid" id="A0A6P8IQK1"/>
    <dbReference type="OrthoDB" id="440745at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF7">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569351.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="55688" checksum="A3247A1E7B37E2B1" modified="2020-12-02" version="1">MALTNPKVPPRFAMSDWHTSNTVIRTNAERQRESSHQIRQEGRWLRNETDNHTRWTQHDSNTKLEKRIDDINDWRKSLERCLAETDHEIALLKIEKERTERALEAKKVPLDIALECLMLRENRLTIDLVRDEVEAQLHKEVEVIEGTKALLQQKVDEASEQLCLLEEARHQLHLDLTDKYTALQIDGDCHTLNNMSANIGFQVNPTRTIKGSVTPETWDSFSNYNKLRAEAEMKASTHLREAIFATLQQTANDLEAQRKASEYAFRKRTHESQQARSELEWQQKNTEKEIANMEDDIKALKEAIDAKNAPMMVAQTRLENRTYRPNVELCRDQPQYQLCHEVAEISGSIRALTEKLRESENSLQALRSNLNRINEDLGVKNNSIALEGRCMNVREKMREVPHSMIDMHPMGPXIGNTQYTTTMNSLGQYTTTTKDTTSPQMILPPXTGGHFNPPTRQYTLPTGYTGSLRAAPQPTLRYTATPIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS98</accession>
    <name>A0A6P8IS98_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116304284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116304284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569849.1">
        <property type="nucleotide sequence ID" value="XM_031713989.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304284"/>
    <dbReference type="KEGG" id="aten:116304284"/>
    <dbReference type="InParanoid" id="A0A6P8IS98"/>
    <dbReference type="OrthoDB" id="5970352at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="372"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569849.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="59237" checksum="1BC4C759503248CC" modified="2020-12-02" version="1">YTRLAIAMSNSSAVPDNRMSASSIYSSTRTAAKARLFGKSSWRPRDDDTKPWLQIDLGEIYYVCAVATQGDPNSDERTINYKVKGSIDDLLWVPVENKTLEKEMVFIGNKNNSTIIIKHSLPSPLAARFVRFYPVEKIKAYAFRVEIYGVTKEPAPPIPPPIGNKELQPSQGSHADLMCRAERGLSIKWYHNDTDITSYSIGSLRTGSILISTLRVNYTSAEDVYDRYSCDKAQRHCTSLDYICQVDYGSYRKLQSRGKISTLLVPTRPRHLNATINPQRGTQRPTVTLKWEKPMRAIGKIASYTLFYNYIIDNNRSMMSLTITDFTGMSYIFNVIGGARFEFYLKAKANGLIGDPSETWTANIQECKPSSAPANVKVIKIDNGKYNVSWNEIPRELSNGKNIAYEINWFSLARRMRRSPFASRAXNASESPYILVNISLTDNMKYNITVRGYTIAGPGPFSDPIVLEKEIKKAEGGYVDKSVPDSVIAVAVVFCLLFVVGMIVFIFWYKRRKGQEDTPQQENPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUQ2</accession>
    <name>A0A6P8IUQ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NACHT, LRR and PYD domains-containing protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571031.1">
        <property type="nucleotide sequence ID" value="XM_031715171.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IUQ2">
        <property type="interactions" value="1457"/>
    </dbReference>
    <dbReference type="GeneID" id="116305291"/>
    <dbReference type="KEGG" id="aten:116305291"/>
    <dbReference type="InParanoid" id="A0A6P8IUQ2"/>
    <dbReference type="OrthoDB" id="5988799at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="191"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571031.1"/>
        </source>
    </evidence>
    <sequence length="872" mass="100412" checksum="1EE3C64F0F4B5A3D" modified="2020-12-02" version="1">MDKTHGIIDEHQQHVEEMMKQTLELTKKIDENQEKVKVGDEEFEVLTSPEVEASKLIEDYSKRLRLSITKQTDFQPKLMPSHLRKNQVIRTDDIFTNLTIQHGRQSLWLDHDVEDDEEMDPEFVTFFEYSEWETDEETDEETDEETDEDMSANDEILLKSCAEMFVYSKNSEKSENPEKSEKEKNDRGNPKSILVIGKPGIGKTLLCQKLIRDWASGHLIFHTLEAQKKPEFCFAFLLXFRQLNPLQQQEFDLRDILNLSCVLDEGSIIDEKTFKLIIXNKENLLVIIDGYDEYSHLDENAGKSNSEETYPNDPCAKMPMHAMVAKLLQKKILEGCVLLITSRPHKTEDLEKGKVNFDQLVEIKGFSMCQVTEYVKKYFKADEKMKNVVCDHLKENKGLARLAHVPMLCFLICXCMEWYITNSKTFENLPVTTADLYSEVIKIFEVKHHSMSQYRKDPIPQKFKVPPVVKDTLSKLSELAVXFMKEXKXVFDEDDLRSFGLNXQEVENLQGSGIIHCGPGFRKSPFAELTLEYSFTHLTVQEYLAAVLLVNQGKIPKREEVTEMVFYFMVQLWXRKKDENTEKLMEELLTSFKPQDQFSIRNVLMTLQFLQQYKDIEFTKRVALDHFKGFCTDPFREVSPWLMSFDRVSNSYCSDMSSLLDIFSLVNEDHLEKALSFPAIELSVNETSLKISGVEQICNSLSNKYSSATGLVLTECKLNNNCIKRISEALLTTNLTKLNLWGNAINGIGMTCICQSLKDKDCKITKLYLGNNDASDFGAEIFCLTIKHENCKLLTLDLHFNNMTNRGVHNLCLALMDTNCKLKELILHDNVTTYGPDYVCHMTFGLVKQAKPDVDLKLTEYPFSTSLGLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUZ8</accession>
    <name>A0A6P8IUZ8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UBX domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116305074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570767.1">
        <property type="nucleotide sequence ID" value="XM_031714907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUZ8"/>
    <dbReference type="FunCoup" id="A0A6P8IUZ8">
        <property type="interactions" value="2514"/>
    </dbReference>
    <dbReference type="GeneID" id="116305074"/>
    <dbReference type="KEGG" id="aten:116305074"/>
    <dbReference type="InParanoid" id="A0A6P8IUZ8"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16117">
        <property type="entry name" value="UBX_UBXN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="9">
        <location>
            <begin position="266"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031570767.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51142" checksum="DB0E31D8C7AC18B4" modified="2020-12-02" version="1">MLWFSGSIPEAIVSSKQRKLPFVVYIEGEDDSSNSMNTVWEDPKVTELFTSDKCVAIKLKKDSEECTQFSQLYPVVCVPSVFFIDQNGMPLELVGGAVGVDEFIGKTSTAFETFQKQISSVQESIQLAPLSSTSNAQEATPSSTVEERVERAKRLIEEKRKEKQEKEKREQLEKETKRRQEGQELTLAKKEKEDRKQREIVNQIREDKAKEKAAREAVLKQIAQDKAEREVRRQNELRERKLAPTVADVPSTSQSGSSDSRTPTKPTSTITRLQFRLPDGSSVMHTFQADALLEAARQFIESQMDSGFNSITLSTVYPRRQLTEEDMNMTLTSLQLVPSATLIVSPGSSTSSAVATSSSSGFSGIVMIILAPFLAIYNFVKVFIFGGSDNPRGSYGGQSNEPRREEVKERGTDSSNLRRRTGNQGIANKEGNIHRLRNKDDDDDENNTWNGNSTQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX91</accession>
    <name>A0A6P8IX91_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116304910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570565.1">
        <property type="nucleotide sequence ID" value="XM_031714705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IX91"/>
    <dbReference type="FunCoup" id="A0A6P8IX91">
        <property type="interactions" value="1237"/>
    </dbReference>
    <dbReference type="GeneID" id="116304910"/>
    <dbReference type="KEGG" id="aten:116304910"/>
    <dbReference type="InParanoid" id="A0A6P8IX91"/>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000148">
        <property type="entry name" value="Os04g0644800 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="758"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031570565.1"/>
        </source>
    </evidence>
    <sequence length="831" mass="92873" checksum="800033EBB3A94179" modified="2020-12-02" version="1">MLSNNSINLPEMTSESSPLLDQSRPRDYYDRTFERTRTESESTGNSLEVNRDFEGMLNRSSGGHESLQKILAKYESLDYDIPENTLYLKEIKSYTGEEIIRTNINRWVVMFIIAVITALIACAIDICISLLSGWKYKNIKNYIEKCTSEHCIAAPYALWVAIDVMFVFIAAMLVTYLEPVAAGSGIPQIKCYLNGVKVPHVVRFKTLLTKVVGVIFSVSGGLACGKEGPMIHSGAVIAAGVSQGRSTTFNKDLKIFEYFRTDHEKRDFVSGGAAAGVAAAFGAPIGGVLFSLEEGASFWNQSLTWRMFFASMVSTFTLNLVLSIYKGQPGDLSNPGLINFGSFEGSPYYGYELPIFMIMGVIGGLLGALFNAINHHLSLFRMQYVKKNWMRVLEACIVATLTVSTAFVLIYFHNDCRPLGTANITDPLQFFCNDGEYSAMGTLVFSTPEESIKNLFHLQPESYTPISLLSFFPIYFLLATWTYGLYVPSGLFVPCILTGASWGRLFGVLLHKAFPKGTWVDPGRYALIGAAATLGGVVRMTLSLTVILMEATGNITYGMPMMLVLMTAKFVGDFFNEGIYDIHIKLQGVPFLGWEPPVMASEVFAKDIMSTPVICFKTKEKVGRIVDVLKDGMSHHNGFPVVEQQEDHSSSDTGQPTFGVFRGFSPIVLHCLLLFHSLGNDRKPAIQSLMWCYTQYILQLHSFLSSVPQLFSDSDRPLRRHGLQLKDFRDAYPRFPPIRNINISQRERECYIDLTPFMNPAPYTVQESSSLPRVFRLFRALGLRHIVVVDDHNRVTGIATRKDLARYRMWSHRGQTGLEVVHVLQSSDLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXI6</accession>
    <name>A0A6P8IXI6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570738.1">
        <property type="nucleotide sequence ID" value="XM_031714878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXI6"/>
    <dbReference type="FunCoup" id="A0A6P8IXI6">
        <property type="interactions" value="3592"/>
    </dbReference>
    <dbReference type="GeneID" id="116305048"/>
    <dbReference type="KEGG" id="aten:116305048"/>
    <dbReference type="InParanoid" id="A0A6P8IXI6"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="655"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="769"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031570738.1"/>
        </source>
    </evidence>
    <sequence length="814" mass="90507" checksum="B36CB540F90BCD7D" modified="2020-12-02" version="1">MVCEEPIRASIWNALHHYAYKDAIFLAERLYSEVNSVDTLHLLATCYYQGGMIQNTYSLLQSKGSLSPLCRILFAKCCYELEKLSEGEMALTGGCLTNGKPIETIASEFGNAAGYALAMLGQICRKSDQTKRAVECFKSSLKYNPCLWSSFEALCNLGEKPDPSEYFKTSACPKIFTSLTHRESMTTGLSTSTLGSTSSINNKRQAEEYMATENLDPSENSTPSFGSGISPEMSDSGFLVPPTPMSSISENRVRARVGRNLLGSNQSSSPLTPSFGMIPLDTPTDQNAVPYITPSPSVHSSNDLHTGHTPKAPVKKGVRRNDTTTKSASTNAQTTTSSSLIYTRASQQTSSSQSILSSPGNKTVRRSTRLFTMNSSSNEEITSDIKKPRSTTRTSTLRKTRRQTRNSIQQPLGTCTTNVIHGETKTAREEQQDKLVRGTPGHNSLEGLMSLLRQIGAAYQKLSSYECKQALILFSNLPPHQYNTGWVLTQVGRAYFETAEYQMAEKTFTEVQRIDPKRLEGMEIFSTTLWHLQKEVALSSLAQDLTEVDRTSPQAWCATGNCFSLHKEHDTAIKFFQRAVQVDPNFTYAYTLLGHEYVLTEELDRAMSCYRMAIKADPRHYNAWYGIGMIYYKQEKFNLAEVHFRKALSINPSSSVLYCHIGVVLHAMKKSEAALATINKAMTIDPKNPLCKFHRASILFSTEKYQKALQELEELKTVVPREALVYFLMGKVYKKLGHTHLAQMNFSWAIDLDPKGANNQIKDAIDKRYLPDDDDSTMGLGCNESSMDQSADAADEEPMGLELDSASSSSMVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYI5</accession>
    <name>A0A6P8IYI5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC116305274</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116305274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571013.1">
        <property type="nucleotide sequence ID" value="XM_031715153.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571015.1">
        <property type="nucleotide sequence ID" value="XM_031715155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYI5"/>
    <dbReference type="GeneID" id="116305274"/>
    <dbReference type="KEGG" id="aten:116305274"/>
    <dbReference type="OrthoDB" id="5981589at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059">
        <property type="entry name" value="ANTHRAX TOXIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059:SF25">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653258" evidence="6">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031571013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571015.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21090" checksum="6E01E77EDBFB7430" modified="2020-12-02" version="1">MRQMLVLFALTLILSTEARGLGRKDENDLEKRLLDLTESEEPLAVERGVCEAQFVKVGCFKDNGLGSNKVLNELLFTDRSRQSPKSSGKLIDWSDYESYLKDLACRCAKAAKAKGYTHFGLQYYGECFSAPDASRVYARDGASSGCVNSFYQACNAEDSNNCVGKAHANFVYRIPEEGSGGGQVDYNGAYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYT6</accession>
    <name>A0A6P8IYT6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Matrix metalloproteinase-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116306723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the seminal plasma protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572676.1">
        <property type="nucleotide sequence ID" value="XM_031716816.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306723"/>
    <dbReference type="KEGG" id="aten:116306723"/>
    <dbReference type="InParanoid" id="A0A6P8IYT6"/>
    <dbReference type="OrthoDB" id="5947142at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051666">
        <property type="entry name" value="SP_Capacitation_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE-II DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918">
        <property type="entry name" value="SEMINAL PLASMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027843390" evidence="7">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031572676.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20028" checksum="DA144843BBEC9D0E" modified="2020-12-02" version="1">MIQKKLLAILTLQIVLLNIYGLTSGVKTTSGKYCAFPFTYKGVVYKSCTTKDHNRPWCSTTAIYSGKWGNCAGLTSGVKTASGKYCAFPFTYKGVVYKSCTTKDHNRPWCSTTAMYSGKWGNCAGFYSNGVKTTSGRFCAFPFIYKGHHYNTCTKTDHXRLWCSTTIHYDKDKKWGNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYZ3</accession>
    <name>A0A6P8IYZ3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="6">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031571168.1">
        <property type="nucleotide sequence ID" value="XM_031715308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYZ3"/>
    <dbReference type="GeneID" id="116305414"/>
    <dbReference type="KEGG" id="aten:116305414"/>
    <dbReference type="InParanoid" id="A0A6P8IYZ3"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571168.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55180" checksum="EF4B23FA64AEE009" modified="2020-12-02" version="1">MDRKSKLSLNRKITSNYVEENDDVESDGEKASKSRTNVVTVKSSKANTTAVFKSGTRNSKDVSITESKSKEITPQVKRSREKNHNISGIVSPKKRNRTIFDCWVNNPRKSLEPAKIVPCPACKTEVLYADINSHLDGSCKGGTNEDIECKRTGELSENVRENKPFIPPKTKQRISNTIAHNKSNTGPIKSLGEMNIKNSMTDILSDQTIKPSPSKYSSQNLISSNKSPEITPIDVDEDEEDILEGLNNELANPLLLSDLESDGKASVECPENLLEMKSALNNELENEEMGNKKANISDNYENDISDDMELGKDCASSDSEFLNGCTLKVADDTELTEGESLDMMEENNDATVNPEQLSDPNYLANFKLVLDSVLSNEEDRKLFNDADQTIIKQFQEFQPAAQKLYIRLFQRKPGWFRCSKLVYSKISEDLTPVLDTLVHSGFLENEEKMTNLKEALQLLSAVELKDLAKALHVIFKSTQQKKECIIECLIKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ30</accession>
    <name>A0A6P8IZ30_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15" type="primary">LOC116306809</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572764.1">
        <property type="nucleotide sequence ID" value="XM_031716904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572765.1">
        <property type="nucleotide sequence ID" value="XM_031716905.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572766.1">
        <property type="nucleotide sequence ID" value="XM_031716906.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031572767.1">
        <property type="nucleotide sequence ID" value="XM_031716907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ30"/>
    <dbReference type="GeneID" id="116306809"/>
    <dbReference type="KEGG" id="aten:116306809"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031572764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031572765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031572766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031572767.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44395" checksum="31D690AC7F006287" modified="2020-12-02" version="1">MADLNKTSNITSTIKPLDRLNICMEYLNVREETNTEISLKITAYSLALGLAMIGNILVIVIVLRKTHFKTTTNLFIVNMAFSDVMMALICMTISIYSIAVKNMGQSTFQGILGLLICKLLPFLQGISVAVSILTLSTLAADRFLAIVYPFQNFISKFRAKILIVLIWMVAALFNAPLIYAMKFYKEGGVMVCYEIWEPYFDEERASKNYTIVLFVFLYAIPLILVTFFYTALIRELWRGKSLHSNKTRAFAENKSVVKMVMTIIIAFAVCWLPIHVNNFIVLFSSDEMIKYCGLKHSIIFIGWFMGHVNTSINPIIYFTYNEKFRKELKNMYRAVREIFAGKKRTTSATTALSIVKPRIIVTQFNAQNDVVTLEPKVGDFGEANSGFEVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ88</accession>
    <name>A0A6P8IZ88_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glutathione transferase</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GST class-pi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116306842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Pi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031572821.1">
        <property type="nucleotide sequence ID" value="XM_031716961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ88"/>
    <dbReference type="GeneID" id="116306842"/>
    <dbReference type="KEGG" id="aten:116306842"/>
    <dbReference type="InParanoid" id="A0A6P8IZ88"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03075">
        <property type="entry name" value="GST_N_Mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000020">
        <property type="entry name" value="Glutathione S-transferase P 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003081">
        <property type="entry name" value="GST_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01267">
        <property type="entry name" value="GSTRNSFRASEM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="10">
        <location>
            <begin position="91"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031572821.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26295" checksum="DD35A1E35DE0CE67" modified="2020-12-02" version="1">MSKPAIGYWNVRGLAEGILYLLNYTKTDYELVEYVTGDGPDYNKDGWLSVKEKLGLPFPNLPYYVEGDLKFTQSLAIMRHIASKHDLCGKTVEQRAFCDCLSLESLDFILGFVKATYFCQNFDEDIKVYLKNIRTNVKRFANYLGEKPYMTGQDITFADFMFWEAMDQLRTLDPTVFDEHPNLKNYMKRIAELPGMKEYLSFQESSARPISNKMAKWGTKFIARPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J181</accession>
    <name>A0A6P8J181_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116307273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116307273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573297.1">
        <property type="nucleotide sequence ID" value="XM_031717437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307273"/>
    <dbReference type="KEGG" id="aten:116307273"/>
    <dbReference type="InParanoid" id="A0A6P8J181"/>
    <dbReference type="OrthoDB" id="6753017at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031573297.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23865" checksum="CBA517924A7E999C" modified="2020-12-02" version="1">MRSLKTAGGLTRGRGMTEQQRTICLLSTPACAETSQAMQELTGVLYNSGEQNKDMTDARQQRYTKDTMTILSLLSDRSPFITSTTLRNIMNGVSAEQNVNADSAKAIGKQIISGMSGQSVLDYSFKRSEQANTFNSSYSVRIDKEQVQIDQQLLFQRLVLACNNADDFQSVFQFELCXYPTALFEAPGVMRQANKPALADALCFQLSSSAVNQSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1P2</accession>
    <name>A0A6P8J1P2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,4-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Signal transduction; phosphatidylinositol signaling pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.66" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031573826.1">
        <property type="nucleotide sequence ID" value="XM_031717966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1P2"/>
    <dbReference type="FunCoup" id="A0A6P8J1P2">
        <property type="interactions" value="2354"/>
    </dbReference>
    <dbReference type="GeneID" id="116307685"/>
    <dbReference type="KEGG" id="aten:116307685"/>
    <dbReference type="InParanoid" id="A0A6P8J1P2"/>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="UniPathway" id="UPA00944"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13258">
        <property type="entry name" value="PH_PLEKHJ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="157"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573826.1"/>
        </source>
    </evidence>
    <sequence length="990" mass="112210" checksum="39D5DDDE6E9FC395" modified="2020-12-02" version="1">MRFNQRELANIATNNDVPFDKEGILWLKEKEGYFWSKNEVYSERLFRLRGNILFYFKTKDKTSEPAGAIVLERCKVQKRQPTIKHAFTIVFDEDDTQLYHLKGKSTKDTEDWIEKIRSASYESLRNKLLSLRRQLMDITGKDPLPEYHPLAVQEPLKPGIGQYSSTSTASNSDETPLLEMCIACNGLVSPIEGRSTNAFVEIRTMTPPSTTWIKHAQTEIIEQKQDPFFLTTVVFPSNGTIQDVTRLKLAVFDVRDREKEEMSILGHAVCTIRDITSAPDQKLYLTLTGLDSSASCGTIIVLGWQAEQNVKTRSSSLDSSEGVEGPTGRRNTGKAMILVDQILTRSYRFPTRKQGKDLKVLELMGESMLTFKIPIQLLKIYIAEEHQRALELHHLGDLNPDWENSRHEIIDNHFKLIFAYKGQLRDLMALKGNSFKPSKLKAHKQLAFVPVNLHLQRLRVNDGCNPGKVYEIVTVGAPVCHTLKFGQGGLKKMMSNLKRIQQSGPESDGKSAVLKQSRANLERLKQLISQLCDRLKQCMKSLNVQHILETLNALSDKGNQLLKLREAPLVTESLSSLEKVVPRPKEDEQVAESSEWQWNVTAFSRDKAQELSKLVQQTLIIMQTHINGLLLGEKPPSGQKWNDVIMGEIHDFSRAADGLAKEIYLGLVFAQLQEDSRHIALRYTIKRRHDIVFSHAVTALIAGFISKLYTNLDNPSFWKQIIHIGFLAQFESLLSTNGDEMGMLEDMCVGVQSLTRVKLKIVQCERDDEIPALSGNRSCIQVSIPVPAESFQLLPKEVQEAKSIRVTPVLFTQGVNEHATLAEKFGDTSLQESINGDNYSILSFYVQQFKDLFPELCGSRFPDDTSIDNLMEQLKVNVEGRKSKNVDILLLSEQLCWRMNGGRFTSCKSAKDRTAMAVTLEQAMTLQREHSMNSEVLQQSLDAMRSEGTRIENAYKNTGFRKYAFNYWQVMALPRLYRPPPGTYGKNVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1S1</accession>
    <name>A0A6P8J1S1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573542.1">
        <property type="nucleotide sequence ID" value="XM_031717682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1S1"/>
    <dbReference type="GeneID" id="116307427"/>
    <dbReference type="KEGG" id="aten:116307427"/>
    <dbReference type="InParanoid" id="A0A6P8J1S1"/>
    <dbReference type="OrthoDB" id="5979835at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="129"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="282"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573542.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="63939" checksum="F9E30A4AF12946CF" modified="2020-12-02" version="1">PQQARLHNTHVWCAGKANADQHLEIDLGLVTMIKSIAIQGNPNDDEFVKTFSLSYAVLEGRWLTYLENGVKRIVSRTFDYLSDFPGNFKSGEVTIQTLQTITAARYVRINPETWFSHVCIRTELYGCEAKPTLPLGMMSGEIPDSLVTASTSWTGLPGSYGRLHWTKYGSNQVWSAGTLDTNQWLQIDLSRMEFVTAIATQGRHAHNQRVTSYYLSYGNDTVLWTEYLEGGVRKVFTGNSDGETVVRHVLPTVMYVRFVRFNPVTWNEHIAMRVEVYTYGRASPADLGIEDKEIPNNQITASSFYGSGFEPYKGRLNLGANSWCPKTKSGNHWLMFDFGHVMLVTSIVTQGRGNDVPFWVTGYQVSYSLDNINFIFYKDNAASQVKTFQGNTNDVGYVTRTLDRDIEARWIRIYPKTWIPSDNFVYSSEVCTNHRYLDDDSRLSTKLTLNLIQDDTNLTENDWYVFRGTRGYYRIPNKCLPQNRCGATATGYVEGNFPTLADVRTFMCATVTPSMSTTLRNSPCPGQRDIASNTIATRTPAGCFKKTHSHSFSVTTSSNASTKCQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1T2</accession>
    <name>A0A6P8J1T2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116307441</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1. Interacts with CD9. Identified in a complex with CD9 and ITGB3. Interacts with PMEL. Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes. Interacts with SYT7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 23">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573557.1">
        <property type="nucleotide sequence ID" value="XM_031717697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1T2"/>
    <dbReference type="FunCoup" id="A0A6P8J1T2">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="GeneID" id="116307441"/>
    <dbReference type="KEGG" id="aten:116307441"/>
    <dbReference type="InParanoid" id="A0A6P8J1T2"/>
    <dbReference type="OrthoDB" id="5969951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000019">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF527">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031573557.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26867" checksum="88554341CA57F9AA" modified="2020-12-02" version="1">MGVEGAARCIKFLVFIFNFLFFVCGIGLMGVGIFVQLKIGDFAELSTVKYVTGSILIIIVGAFIALVAFFGCCGAVKENTCFLGIFFGILLLILCAEIAGTVLGYIYRGKVEKNLRTDLNNSIALYGEKGQDGITKAFDSLQQKEKCCGVNNYTDWQRSPFSNGSHDKVPDSCCHDKKPGCGEKWKTNPPESEIYKEGCYGKVETLVKDNLMLIFGLGIGVAVIQIIAMIFAIILICKIREQGSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2Y2</accession>
    <name>A0A6P8J2Y2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane protein 163-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116306487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM163 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572418.1">
        <property type="nucleotide sequence ID" value="XM_031716558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2Y2"/>
    <dbReference type="FunCoup" id="A0A6P8J2Y2">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GeneID" id="116306487"/>
    <dbReference type="KEGG" id="aten:116306487"/>
    <dbReference type="InParanoid" id="A0A6P8J2Y2"/>
    <dbReference type="OrthoDB" id="5980560at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031572418.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29292" checksum="0BE8064B5D1B7784" modified="2020-12-02" version="1">MDNKSKYGTNFILKDHENDIRNGLKPEDEDTVPCVSPNDDDYLLNEKKHYMTSQSISKWRKAAIAISLVSLVCTFVIGVTAFSMSSVAKSSAAFGFAFDSLLDVLSTLVVLWRFVGDKGQTLTWDRERRACIVMGVCFIVSSLGILVRAVRSLIVDRHPHEFIGIQIISGVCLVVFSVLAWMKFVVAERLSSSSLKTDGFSSLAGAVMALGLLMSSLSYEENKSVWFLDAAIALCISVCLGAYAVRLLSQMIKPLPSKRSRVDTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3I5</accession>
    <name>A0A6P8J3I5_ACTTE</name>
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        <submittedName>
            <fullName evidence="12">Zinc finger protein 782-like</fullName>
        </submittedName>
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    <gene>
        <name evidence="12" type="primary">LOC116308003</name>
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    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="C2H2-ZF_domain-containing"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
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    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
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    <dbReference type="Pfam" id="PF00096">
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    </dbReference>
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    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574212.1"/>
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    </evidence>
    <sequence length="167" mass="19875" checksum="1E66356688D7DB91" modified="2020-12-02" version="1">MGCPECNKEFSSKQRLRNHAKRGVCAPIVCDDCDKEFSSKQRLRYHVDNAVCRRTNKCEDCGKVLSSHQRLLSYEKTHEVVFQRVAKSYDLEGVDCYECGDIMSRCKHNDEYIKDRIRYKRKMHKTFPFFDLVEGVPWTNREYWRQECDRCGHVREEEHITNGCLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Y1</accession>
    <name>A0A6P8J4Y1_ACTTE</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307044</fullName>
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    </protein>
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        <name evidence="4" type="primary">LOC116307044</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="RefSeq" id="XP_031573043.1">
        <property type="nucleotide sequence ID" value="XM_031717183.1"/>
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    <dbReference type="GeneID" id="116307044"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028251175" evidence="2">
        <location>
            <begin position="24"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573043.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13655" checksum="FD4C1348CAB476D2" modified="2020-12-02" version="1">MKFQIASIVLLAVIFQFGHRVSGKCQGPQAGLFDTDWATCLPAVDKAGTTCPHNFLKIGDNSYGCGESHTFIRDSNHRRVVDKPFICCLLTPVIDMKVKDAPCLSNSGGSNSQKDLQDKIESKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J573</accession>
    <name>A0A6P8J573_ACTTE</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116308875 isoform X2</fullName>
        </submittedName>
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        <name evidence="10" type="primary">LOC116308875</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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        <lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
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        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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        <property type="match status" value="19"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="47"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="114"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="147"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
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            <begin position="180"/>
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            <begin position="213"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="246"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
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            <begin position="279"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="312"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
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            <begin position="345"/>
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    </feature>
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    </feature>
    <feature type="repeat" description="ANK" evidence="5">
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            <begin position="433"/>
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    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="466"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="498"/>
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        </location>
    </feature>
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        <location>
            <begin position="531"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="629"/>
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        </location>
    </feature>
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        <location>
            <begin position="662"/>
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        </location>
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        <location>
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    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="728"/>
            <end position="760"/>
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    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1516"/>
            <end position="1742"/>
        </location>
    </feature>
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        <location>
            <begin position="1379"/>
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        </location>
    </feature>
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            <begin position="1391"/>
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    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031575246.1"/>
        </source>
    </evidence>
    <sequence length="1742" mass="193260" checksum="44E46F33ED34934F" modified="2020-12-02" version="1">MFGEEQMSLSEEDGNLDLFNAVKNNNESAIRGSLDAGADVNITDESWKRTPMFYAVLGNFENVVHVLIKAGANVNIKDREENSCLFFAVLCDHSNIARALIDAKADVNAIDKFQKRTPIFYAVSNGNGELVDALIDASTDVNKTDSDGQTALFCALRSKNDNIVRAIIDAGADVNKTDSDGQTALFYALRSKNDNIVRAIIDGRADVNKTDSDGQTALFCALRSRNDNIVRAIIDAGADVNKTDIVYQTALFSAVENDNESIVRVLIDAGADVNKTDVVYQTALFSAVRQDNESIVQALIDAGVDSNKTDKYGKTALFIAVDKHNESIVQALIDAGAVVNKTDKYGNTAFFIAVLHDNKSIVQALIDAGADVNETHRDLNETSFFDAHLFGNNYESAYHDGETALFGAVREGNESIVRTLIDAGADVNKTDKYGKTALFGAVGKDNKSIVQALIDAGADVNETDKYGNTAXFIAVLNDNKNIVQALIDAGADVKTDKYGKTALFIAVDKQNESIVRALIDGGADVNKTDNDGQTALFIAVDKQNESIVRALIDAGVDVNKTDKYGETAWISAGSENNVSLIPTLIDAGADVKTDSDGPFALYCAILNNNESIVRVLIDAGVVLNNIVNDGETALFSAVENGKESIAQALIEAGADVNKTNYYGKTAMFSAIEYENESIVQALIEAGADVNKTDDDGXTAMFSAIEYENESIVQALIDAGVDVNKTDKYGNTALFNAVENNNESIVRALIDAGVDVNKTDKYSKTALFCVSLFFNFSSGDSIDLLIDAGSDVNLPDNKGETPLFSLVRSQLDIHVKTLVEKGKALTNVRNQYGRTPLFYALQRSPVVALYLLYNGGNLYLKDNCNLSILSFFIEEMLHDEIRFDRSGRFDLTEQLNLLCRRGVTEKLVVKSLIEVLFCKIVLMCTPLGEVRTSYSYFMHKGCLSEFLSMADYQTKMTIENILEQVSSEQLSQVVPSFVNLGADPNSVDSHGNTLLHYVTLLPFVDVSQKEVVETCHLLWKYGASMNIKNHQGQTPLLFCLSELSLHWEWLLRTDGVKMLVEVCRLLLNCGTNVNDTLPNGESVFHLLIDLFQKGLRLQDEAVRQELLKEMFNLLQLFSDANCKQAESFKNSSGHLYLLLHSWASLTLPYSENYSRKVTHNYTFEELLKAILQLLLKCGAKQNARDDDERTPLHHCKTWSAVKLLIDAGAKTDDVDSSGHPTLLAAAGRQTFLERSDRFYPDVLEDPKAFWRTAIEMNLDPWTVDQHENSVLSNMIECKAFVLVKALIEVTCEDKHIESHTIAYSLLSTICNDQSTHARWKTNLVEIILNSRKTLLVNLDVPLRFCCKNIIELGSSDDSSHDSLHPSKGLKRKFADNEFEKHGSTQPMLKKIKTTDGRCSEEKTDGQCSEEETDGQCSEEKTENAKNSDDLVHYDSVHCEIAQLLLSYGADCRISDSTGKSCLDLAETCPELKHILMQPIDMNKISKRIPWDSVSERYKNMLAKVSRGQEKQIVGSFWYHKDYIGSGSYGHVFTGINENDGREVAIKRIEKLRMVRPEDQREITNLANLADCKQVVSHVCFLEDIHFSYIVLELMEGDLEHYFSERTVDKRKSVLLCKDIVEGLRYLHERKIIHRDLKPGNILYKTHPTLCLKIADFGLSRYCRVNNTSTTLYGRTIVGTRCWIAPEILTSQSAGENFTKNSDTFSCGLLLHYILSEQRHPFSPAPSSNPHFIEDNIIKDKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5P9</accession>
    <name>A0A6P8J5P9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116308701</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575042.1">
        <property type="nucleotide sequence ID" value="XM_031719182.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308701"/>
    <dbReference type="KEGG" id="aten:116308701"/>
    <dbReference type="InParanoid" id="A0A6P8J5P9"/>
    <dbReference type="OrthoDB" id="413581at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF5">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027700089" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1239"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="904"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="7">
        <location>
            <begin position="945"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031575042.1"/>
        </source>
    </evidence>
    <sequence length="1300" mass="142231" checksum="A68C0E77F91A6205" modified="2020-12-02" version="1">MAIQENFILYLILVSIAHLDGVLAADFDLCGLGDITSKDGSIFFNISEVGSEGEIECRRLIHVDKGHVRLTINTSEAVFQGKNILQVFDGGFNARQLNSEGPKGQITYESSGNVMAILLRVEKSAKSTENIVRRGTFISLPFQTTCACGGIQNGVQQCWESFGVRKCEATCKNGFVDLTESTGNFSCSLLNGKWDKDLDGFGCQSTILPSVVFRLNLTFANASLCTASTKDNISTFFNEYFKDNKNISANGQCFGQHNASNCTVIECVENDNSSFVSITIEDKSITKSKSVEEKPTVVDLFTVYNSTSKGIEEQLFAFINNILKNTSALNKAENNVERQCPSGLFLFLNAGDIGHPVCSKCPAGRFYSAFKCEKCPNGTFSLEGSVTCSPDESQKITPSSKDLCKIYCSVGKGLNLTTGFCQWCPYDTYQNSTDVPNVNCSACPKGKMTPYPGATGMDQCYVPCKKGTFFSLKDQKCLSCPLGTYQESGNHLFMRCKNCGLGKVTYENGSTAPDYCVTSCPKGRYLDSTTSQCLECPLGSYQDKVNQLNCTRCRDGTFTLKNGSIERNDCIKTCLMGTYFDVQNQSCIECPVGTYMDQNGHLILSCIKCAGNKTTQGHGAINESQCLGKCDVGEYLNTQNNSCSKCPVGTYMDQKGNLLLSCIKCVDNKTTHVEGAGNENHCLHRCKPGEFFVAENASCPKCPSGTFMEQNNHLIKSCNKCGANQTTQNEGAVDKSQCIDTCGKGEYFSVKNSSCALCPLGTYMDEGGHLRLSCKTCGNKNATYKKGAVSENQCMIECKVGQYFNSTTSTCEACPKGSYQNKTAQETCLSCPPGMSTTSAGETSVLACVKYVCGRGKYVESTGNCQLCPNGTYQSAVNHTLSSCQQCPSNISKVQGATNLSSCIKICDSFPCENGAECIEKADAYCKCPRGLTGKRCEVIEKQDELIKLQMGVRFTSLHWSEQLTDKTSSEYRGVKYRIENSLRNVFIDDESFVGVQVNKLVKGSVIANFDLYMNENASVVPAKTLQIAVKHGSIGGLAVDAEYLSIKQVTCDRALGMENGRIKDEQISASSKSANQHASRARLNSPKGWHAKEVTSKNYIQVRFHSNVNVTAIATQGDAVGSFVTAYVLSYSTDGDVWMDIKESINSTFAKNFTANNDTNTIVKNILPEPITLVKYIRVIPVSWSNATGMRIEVYGCITDPILPPEEIPTTFPKQTLMTEPKVKAVASNKDEYSWGKYLGITFGLLMVVGCLLAFFMWWRSSKKKEQKEKAPLVMTKLHGNEYKVINKNDDLEYDENAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5Y7</accession>
    <name>A0A6P8J5Y7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM114A2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM114 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575144.1">
        <property type="nucleotide sequence ID" value="XM_031719284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5Y7"/>
    <dbReference type="FunCoup" id="A0A6P8J5Y7">
        <property type="interactions" value="1536"/>
    </dbReference>
    <dbReference type="GeneID" id="116308794"/>
    <dbReference type="KEGG" id="aten:116308794"/>
    <dbReference type="InParanoid" id="A0A6P8J5Y7"/>
    <dbReference type="OrthoDB" id="5597648at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007998">
        <property type="entry name" value="DUF719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842:SF6">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05334">
        <property type="entry name" value="DUF719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575144.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="74498" checksum="E3A7D2BC9F7E53CA" modified="2020-12-02" version="1">MDKPKRSNRVKSESSEDEDDFESADEGEESRQNPRPPSLATSADDGKNSTSKSQVTKEKTGQKTQEMAAPETFSSLPSDKSEEIEKTEGDTSNSSESCPTGVDQGVDMRSSKSADLEGDLSHSDLQEQKPEGNEDSKPSGDGSVAQDVSDDDEIQFKIDSEKPNVDTSELEKTQVDKTLEVHKESTHQEDDNEDFQNIKVEEEKGSSIEKKEDSNAEEKSKENAPDERQANVEDSAKVDKISSEKSAEAVGESVKPPPKEGAEPHCEDVWGWGGWGTMLSSVSSGLSSVIEKVETSLGIPEPEVMAKKITEDEKQAKENQPEKVIETEPTTESPPEGPTPESIEQARGEEEDSSYFAGFGVRGLTDVVSEGLGALEYIGKKTMDVISEGDPGLRSRREVLMPKEPTLSQMLREAKEEAEYKASHPDHKEAIVNFSTEFDKFQGLAHLEALEILSKDSLSKVEAHFIDLSSEDLKSVKPLLRTIQEVVKFTEDEEENDDDEEQDFESELSEFLKDLNLTHIPNKTKDVDKRVREWIDACITEQNDDPLSKDHLEIFTAGISALAELTATTIEQFHKIAEVLLLLAENTDTSALVRAQSLKKLTVCVSREISNLSSKFAGCLSTVSKESQDPEAIESLITTLYLESSDSSRYLQHALKLLCPVLQHSSLTENTSAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JFD2</accession>
    <name>A0A6P8JFD2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TM2 domain-containing protein CG11103-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116308697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575070.1">
        <property type="nucleotide sequence ID" value="XM_031719210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JFD2"/>
    <dbReference type="FunCoup" id="A0A6P8JFD2">
        <property type="interactions" value="1124"/>
    </dbReference>
    <dbReference type="GeneID" id="116308697"/>
    <dbReference type="KEGG" id="aten:116308697"/>
    <dbReference type="InParanoid" id="A0A6P8JFD2"/>
    <dbReference type="OrthoDB" id="408511at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="129"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031575070.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22174" checksum="0274EF8A69A6A8A6" modified="2020-12-02" version="1">MAEGCWQRVFSLLKITTVFIILFYKIKVQAKETDSSCANESCDVNFNPKGPLIKCEFVPRDFLECEPPQDLHGNSTYKIELGYGCSKYGGLRYEEVERSKVWCEVLPGIECHGKRRFLGHEEPCIKYSGHYFVTTLLYSILLGFLGVDRFCLGHTGTAVGKLLTIGGLGIWWVVDIILLITGTLKPEDGSNWNPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JGJ8</accession>
    <name>A0A6P8JGJ8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575385.1">
        <property type="nucleotide sequence ID" value="XM_031719525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JGJ8"/>
    <dbReference type="GeneID" id="116308998"/>
    <dbReference type="KEGG" id="aten:116308998"/>
    <dbReference type="InParanoid" id="A0A6P8JGJ8"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031575385.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22965" checksum="BFC845202BC068E4" modified="2020-12-02" version="1">MAMEAAPSSPQLSTYAPQTNVAVTHAVPSTHNAVNIIPPEQSKSLFIVDPSQQHALQMYANDRAFMTAANSVEYNGGAITVPVTNSNNQIMMSGQPISAQRLPVAMETLDEPLYVNAKQYHRIIKRRQARAKLEAEGKIPKVRKKYLHESRHQHACRRKRSNGGRFVTKTGKALRLAERNNEIESDEHDIDKMPSHGQLASEQTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H158</accession>
    <name>A0A6P8H158_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116286947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031549403.1">
        <property type="nucleotide sequence ID" value="XM_031693543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H158"/>
    <dbReference type="GeneID" id="116286947"/>
    <dbReference type="KEGG" id="aten:116286947"/>
    <dbReference type="InParanoid" id="A0A6P8H158"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050547">
        <property type="entry name" value="DEAD_box_RNA_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963:SF3">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="204"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="409"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549403.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="64846" checksum="A9B88D1FFFA5C37C" modified="2020-12-02" version="1">MMLRKVCCRSRVQLARNSLLLRSCFIFNARYFHQRRLTSPRKVRTKETGIDKGIEGTKKAAKAKVPDVEFLKLWKSTENKYKSQLRGTMMGKRAAKTQSKDLNMKTVPRQSVLIKEEAFQVIEDNDFGFRVPSFSEVASKLNLGRQFEKKPSFEKMEENEKMSGDLDIVMGDISFEDIGVHPKLIKKLQKEGITSPVLIQERALPLIYSNKSILIKSETGSGKTLVFLLPTLQDPGKSYGTVIVVPTRELASQMLYKAHRLLGDKSIVASFVSGVDLSSQEKRLQDMTNPPRIVIGTPKRLLEIVEANESLFLKTKRIVVDEVDKILLPLHKRASQKMITNRVAHPRSGRLLVEKIAQISKVPKKQFIGASATVNISLLEDLVDMGWGDHVTVVQSPSYEGKLRSIPSCIRHRYTYFNEETDPSKAHVLVRTFQNSKQKSALVFIHRNLSVDDFVWELRYMGFKAAALYRKIASQNPLNHEHFLADFHSGKIQLVVGTEETVRGLDFKDLEHVYLMEVPKNTEEYLHLAGRVGRQGKEGTVTTIVSKDPRGGERRMLLQYRRLAVPFQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2L7</accession>
    <name>A0A6P8H2L7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Down syndrome cell adhesion molecule-like protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549661.1">
        <property type="nucleotide sequence ID" value="XM_031693801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2L7"/>
    <dbReference type="GeneID" id="116287158"/>
    <dbReference type="KEGG" id="aten:116287158"/>
    <dbReference type="InParanoid" id="A0A6P8H2L7"/>
    <dbReference type="OrthoDB" id="5988052at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF335">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028444829" evidence="1">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="169"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="265"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549661.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40419" checksum="E6AE662572F78664" modified="2020-12-02" version="1">MLLLALFCGISLQKVSGSQPITGCDRNSVGIQYRSVIPDSSLTASSFFNIYFAPQHGRLHDAYGWSPITEYNERDYLQIDLGGLTEVCGVATQGCGNNNEWVTKYKLHFSKRGAIWDTYQENGTEKIFQGNSDMSTVEIRCLQNLQSARYIRFVPTAFHTYKTMRVEVFTSYLDGPKIIPHQRSLQLTWRIMDNITVVSYLMEFKNKSRIESLILPNDTMEYNLTNLQPYTEYSVRLKGMLTSDGAGVWSNWINAKTAAAVPECSPVITNIQAISSTSISMAWQQDPTCLNGILRGYIIQYSLLDNSTVQSINITDDRLSTSRNVSGLRKYTIYSFRILAYTIGEGPLSNASVIRTAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3Z4</accession>
    <name>A0A6P8H3Z4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galaxin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550176.1">
        <property type="nucleotide sequence ID" value="XM_031694316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287633"/>
    <dbReference type="KEGG" id="aten:116287633"/>
    <dbReference type="InParanoid" id="A0A6P8H3Z4"/>
    <dbReference type="OrthoDB" id="419529at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055284">
        <property type="entry name" value="Galaxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056601">
        <property type="entry name" value="Galaxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34490:SF1">
        <property type="entry name" value="GALAXIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34490">
        <property type="entry name" value="PROTEIN CBG12054-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24748">
        <property type="entry name" value="Galaxin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027639983" evidence="1">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Galaxin-like repeats" evidence="2">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Galaxin-like repeats" evidence="2">
        <location>
            <begin position="185"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550176.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="42916" checksum="FEE1EA1FCDC0B15C" modified="2020-12-02" version="1">MKIVLILTLTSMLATAAAAIKYCGIYPYEPKIQICCSGIPQIKPNKFISCCGKSSYNRQSQYCCAGVVKQKSSNTYCCGKTTYNSLTQICCGGKVVTKNSSSMSCCGSKVYDYRNQFCCAGIVISKGVHNACCVRKPYNTLTEVCCSGNLFKRNSSTSCCGSKAYDYRTQFCCAGKVMTKGVNNNCCGRAPYNTATHICCGGQVKTKDSPTSSCCGSKVYNYNTHFCCSGIVKTKGDHNACCGRKTYNTMTQICCGGRVSNKSSPSTSCCGGKVYDYQTQFCCAGVVKPKALYYNSCCGRHPYHTEKHICCGGKLTMRGXXXSCCGSTVFDYSTQFCCAGVVKSKGVXSACCGRTSYNPATQICCGGKLSKKDGLTSCCGRTAFNYKTHFCCGGVAKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5S5</accession>
    <name>A0A6P8H5S5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116288998</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2 13"/>
    <dbReference type="RefSeq" id="XP_031551729.1">
        <property type="nucleotide sequence ID" value="XM_031695869.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116288998"/>
    <dbReference type="InParanoid" id="A0A6P8H5S5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000096">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF147">
        <property type="entry name" value="CGMP-DEPENDENT SERINE_THREONIN PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0140">cGMP</keyword>
    <keyword evidence="10 13" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="164"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="282"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="463"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="722"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="469"/>
            <end position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="22">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031551729.1"/>
        </source>
    </evidence>
    <sequence length="772" mass="88038" checksum="EC7954DA01E2F2DC" modified="2020-12-02" version="1">MGNGASNAGTTIINGEIDKPSENLNNFKSQLPSLRKELKEKDELLQRKDAELKHRMKTIDEKDVEIAKLKKEIHELKCVVNQQAALASKMSVMSTINEGSGMASTPNANNKSRKVRSSRKEKRQAVSGESSTKTQEESKKELVRYPKDFRSKQLIKDAIYENDFLKNLEAAQVREIVECMSPQSCDKEEVIIREGDAGNALYVIAEGRLDVTKDGEVLGEMCGGMVFGELAILYNCRRTATVRAIEATTLWKTDRKMFQMIMMRTGMIRQAEHISFLKSVPLLKNLPSQHLSKLADVLEVDFYHAGDYIIREGERGDTFYIISKGTARVTQRIEGHDQPKEIRKLKKGDYFGEKALLRPTTDYCDAVLSYGGAIDQEVLSKMQSEDRRTANVISEAAEVECLVIDRTAFKTLIGNLNELRERNYGDEERGAKRYADLRDSNGLKPVEERKISKKIEDLTLEDLEVISTLGTGGFGRVELVQNVKDKSTYALKCLKKKHILETKQQEHVYSEKRILMEXCSPFICKLYRTFKDRKYVYMLLEACLGGELWTILRDWGSFDDVTARFCIACVVEAFDYLHCKGXVYRDLKPENLLLDSQGFVKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDLSADYWSLGILIFELLTGSPPFSGSDPMKTYNIILRGLDMIEFPRRIGRNPQNLIKRLCRDNPVERLGYQKDGLNDIKKHKWFQGFHWKALLDRTLEPPIKPKVDSNTDCSNFDIYSKDMEIPPDDLSGWDENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6A4</accession>
    <name>A0A6P8H6A4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288380</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551021.1">
        <property type="nucleotide sequence ID" value="XM_031695161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288380"/>
    <dbReference type="KEGG" id="aten:116288380"/>
    <dbReference type="InParanoid" id="A0A6P8H6A4"/>
    <dbReference type="OrthoDB" id="5959603at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028357407" evidence="1">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551021.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32069" checksum="0D51D5E0B1D139B5" modified="2020-12-02" version="1">MKTIKAVSILLFCGVTLLSNAAAQTTIKFLPVLFVSXAPDRPAPDSAVIYAATICDGKLYDGNLTVARVNLPNGWKPVIGTYAKLEVCSDEECTKIYCXNWASGKFSGNHYCNFTYNATMNDLYLRVTAGPSPNIDWTVAVEFLNTKTPLLERPPLRNAMDFPEPIAKDGVRANVQVLMQIVKTAAEQTVLTLGHDEFLFRFCPDRQTGDRYDITVAVTGTDSKSAMATYVCLPNELPCSVSSSTHYDPRGIGINTVTXTTGSSQLSELHVIVVGWGDGEQTNTFTLGATVTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6Q0</accession>
    <name>A0A6P8H6Q0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552074.1">
        <property type="nucleotide sequence ID" value="XM_031696214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289324"/>
    <dbReference type="KEGG" id="aten:116289324"/>
    <dbReference type="InParanoid" id="A0A6P8H6Q0"/>
    <dbReference type="OrthoDB" id="5989029at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552074.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31197" checksum="5F6F1579E028B73F" modified="2020-12-02" version="1">MRNVELSKKLAGELQVNTQGETKNITYNLGNIIMDGDTTTIAHVHKEVDPNISIWXDIGHAKKALHSHLLKIGXKHKSLSKTVTEYLTKCFGYVLTQNKGNPQGIAHGCKVIPQHAFGDHSSCGTWCQYVFDIFAGYADKLAPLGSTQSNEGVNNSITVVAPNRIHFSGSESLATRVGLAVATKNNGYGVISQLNEANNLSPGRITMNFNSERDRQYSMRKHRESTKQYKKNRIVRRKQRSMNTKESEVLEGPTYKSGVQFSTKDQLDDLTNIPNPVFAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H788</accession>
    <name>A0A6P8H788_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116288673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551356.1">
        <property type="nucleotide sequence ID" value="XM_031695496.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H788">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="GeneID" id="116288673"/>
    <dbReference type="KEGG" id="aten:116288673"/>
    <dbReference type="InParanoid" id="A0A6P8H788"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="173"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551356.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43305" checksum="8ACA601AD26DB308" modified="2020-12-02" version="1">MLVLMQHQQARMRMAMIMRRRRLRQNIHRRSPWSWTLPRPAESWFEIHFFDRNISEDYFRKQLCMNRNTFQALVGILEQRIRREDTRLRDCIPPEKVLAIGLYRLAHGNSYVSIGPVFNVGKSTVIEAVQDVVGALFELRNEYIHFPETLAETAASIETFADHSDLPNIVGAIDGTHVKINAPKESKVDYFSRYQQYDFIIQGVADGNLXFLDFSAGYPGSMHDGRVLRNSTLYGRAEQGDILTVPVVDVNNHDIGPYLVGNSAYPLSPWIQKPYXEATRDRSEIRFNKELSSARVKVECAFGCLKXRWRILSKRLDSNIEFYVQISIACAVLHNFCIKMGDNWDDNGPGNHNGDDNNDDVEKDXEEIRDILKSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7Y8</accession>
    <name>A0A6P8H7Y8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC116289756</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116289756</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552559.1">
        <property type="nucleotide sequence ID" value="XM_031696699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289756"/>
    <dbReference type="KEGG" id="aten:116289756"/>
    <dbReference type="InParanoid" id="A0A6P8H7Y8"/>
    <dbReference type="OrthoDB" id="5964820at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000434">
        <property type="entry name" value="PC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00500">
        <property type="entry name" value="POLYCYSTIN1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1984"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2191"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2231"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2311"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2343"/>
            <end position="2374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2437"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2771"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2811"/>
            <end position="2832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2852"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2886"/>
            <end position="2914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2962"/>
            <end position="2983"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="15">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="15">
        <location>
            <begin position="306"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="15">
        <location>
            <begin position="492"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="15">
        <location>
            <begin position="845"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="16">
        <location>
            <begin position="2028"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2280"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1416"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031552559.1"/>
        </source>
    </evidence>
    <sequence length="3118" mass="348675" checksum="8E2DBCCFBD707707" modified="2020-12-02" version="1">MESRFSFHLGVSPLLGIFILFLARFVVPVPANPLNVCVLLRKGYPCNITISPHTIPMTHGYKLNFGDGSSEVTFSDTSTVTPHTYTSVGVYTVTLTINPGGSGEIFTKTITVKEVISNVTVHMPSFLCAVGGKINFTSSIVPVIPVTTYVKLGSANWTEGSLIMCDQVGSQSLAVFIENGISAVVMKCLLNVTVLSFNFTWSPPYYAPGAMVPFALTKPAGNYGIIMLFPGPVSVNCTNDTIYHSFATPNISPGHNVVMIVTDSVGSSAKINKYILIYPKLNGTLNVVYPAFGGMGMLLEYKVVITADNLSHSFNFSDGSPVLKSIWPNATHTFNTKGVHCIEVITSNPVSSLSKTVCTRVVEAIQGLACAEDLIRTPLGQPSSIGFVVENGTDFDLKLQINALFPTFNVENATAHDIFVVFKQHNFTEEGEYSSTVTASNIVGNATAKCLVLVQRPIENLDVQLIHDTNYLEMNATLKLVVTVNGTSPLIEYNLGDGTPALNTTSQTMYHRYQMYGIMMINITARNNVSQMTINRTISVPKPVIPLQRLLLRTEYVNLTSPTVLSMRIGQGSDFNCTVHYGNGINKTYCYNMVYYENAVSLDVTPFLNLDLNESYVYPVEGYYHLTTTCFNRLTNVTNTTYAYVLKPITDFVLPPLPPQIFGSEISISFNMAAGTNVTVYFYIDGKQMDSTAYVTDSGGSVLMKPYEHYSQVTHYEIKTYAKNLVSEYNSTSYLMTLQIPITELTCNVTTTTPYPDVGIQRCRNESNIFPAEHPIIFPANPNNGTNLTCFYLFGDGAMTNTSNLTVTHQYAVQHRRYEPSVTCSNLVSSVTCCFPITMEKKVKAVTVSNDGPKKFNNTITFTLNVXDYGTGTCFAWDFKDGTPIDVYGQSHCSKLTFPRGQRFFPIAEGVTSINAYHAYSTVNQFFVKIQATNNVSCIETENQAVSVLKECFYPNVSMRVAGKNTSLAAQIRRSETFQVSNEVGVYCEVSSVTNYSWIITKVQDMKNNTLNPPQVMSLPSVKLNAPIPTFFERTLPYGTYEFNVTVYMEGTIGVRTIEIGYFAIVCTPYIIANIKEGCLLKRKVGSVLTSGGCFGTGKGRLPYNSTVISLDTSLPGIDDSQSLVVSLVVVKNDSCGIRIGTFDQVIQLTKQDIPVLSTKCTQNCDLKVNSNQKLAYEXTCEGCDVDTTYKWEIFELKSCDGGPLDTSNMDQILDATVTGMMAGDSSSLHMVILENKLVGDKCYTFKLKATKKNGVYGDNAFTIRTNDIPHSGSMNINPRTGMALNTTYAIYLDNWIDTDLPLAYECGIRQGEDFKILAKTQEPPIGLKLPAGDPQNDDLLEIECWISDRAGAATVVNKRVQVKPMNITEDKLLNFLNQTINGKDGPLSKAVQEADFAAIFQLTHSVSNMMEDMYSAAEEAKKQNLTEEQKQVLQQEEXQRSELKLSLMKTLSTVDIGTLTDGKLMAGAVDELTKGYKDLGSTSQEMGLSILDKIKNQLLNAPVTDTGFSDVIDTSKSLISAMTQIGLSSAIAXKFNSSDSQFDITGITSNDSLSGLVSSSERGKERVLAIVDSVNEIGKRIQDAMLAGEPFAVLKSSQINSTIGKAWYKDLGGMNFGDGRSEIVFPSIESMGLKISDTTKDYMNLMSTSTKSTLFTWSNTSSQVKSQDVSIKMALPLHKPLDTSHFTEDAIIYIPKSAEEIAPLENHFMRIYKEEENSIEYLQIHSFEFTSPDEASHIQIFPQNETHLYQAFLQYNERAYPEPGKYIYNWTLPNFSSCNIRYINQSKEVTVGNTNHEVVEVVPKRDCLTDPNTVFIPFSLVNKTGTYYVSILYQNQGGSNPSDSPLSRQKRAIPGTPCGGHGRMKRSCVIIPPPPPKPPTDPPWGAPQLVGTRPPNVDFLGRPIDFNNTIYYDVRIYKTNCMFFNRTANTWGNNGCKVGNETRQDRIQCRCNHFTSFGSDFFVAPNPIDFDKVFSADLSKNPVVLSVVCSIFGLYLILAVFARRADKADEKKTGVTPLPANAAPGSHSYLVSIHTGVRMNAGTTANVCIVLSGENGEGPPTLLKDPERPLFTRGADNSLVMTIPYDIGRLTHVRLWHDNTGDNPSWYLSRVAIEDLHTHKKSYFVCERWLAVEEDDGRVDRILPIASKKELTQFSHLFVGKTVRELGDGHLWFSIITRPPQSVFTRLQRLSCGISLLYCTMITSCMFYNTGGGQENPTYVLYIGSLKIDLRQMVIGLQSSLIVFPVNLLLVQVFRKIRPNEPANSDDDDFSEDFEDISTCSDEEERAEKSEEKKKKKKEKKKGLHPRWRYVAWTVFGLSTSVSATFTVFYSLSWGPEVANKWMVAFVLSFFQSVLLIQPIKVLLASVVFALIIRKPIATEDENQDDLPDTIESNNKSLFADDLGCYDKGVTRGPPDEFMLMQARQKRLKEIQMTTILREIFAYFIFLGVLLLVAYGNRDPNAYLLRKSLMQQFVDFTDEENVGLGSAGDADSFWHWARETLIPGLYPGPLYNNKSDKYTGFITDRNNYLVGISRLRQERVKKDTCTIAPVFRHEFPTCLGGYSVTAADTGDYDVGWKYLNKSTTSASRKRRSLEEQFSFVRENSKMVKYGDSSKVKPRMRRAVEPVYVSTSGRQQRRRVKSGESKVYFVLDSAILPDGSIMSCPARWMYHNPIELRGFPYWGKLYFYGGGGFPADLGYDYSTALTVVADVNSHNWLTDQTRAVFVEFTVYNANTNLFGVAFLFMEFLPNGGAFPSAAFSISRLYSYVGPFAKLILAMEVLMLLFMFYFMYREVKLMVKQKKQYFHGFWNWLEVALIVLEFVMVILFFARMWETDKNFIKLHENPKDFVSFQYASASDMTLTYVIGILVFLVTLRFLKLLRFNKKMAFIGTTIGFIAKPIGLFMISFSIIFFAYGSFAHLVFGPINDNYKNLLSTGVTQMRILLGDFDYYDIEXSDPILGPIYFFTYMYVIVFFLMNMFLAIINDSFADVKDLENEMANEYEMVEFILSRFRAQFNFMKRPNNHVKTPLGLGPDIPFWEYKHRRDSIWNDSEFSTNTDYESLKIKRNVFAMGKDLDDLLERLGDMHKEDVESDELLMMTLQYANGPNSETTSIASDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H856</accession>
    <name>A0A6P8H856_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289834</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031552624.1">
        <property type="nucleotide sequence ID" value="XM_031696764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H856"/>
    <dbReference type="GeneID" id="116289834"/>
    <dbReference type="KEGG" id="aten:116289834"/>
    <dbReference type="InParanoid" id="A0A6P8H856"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552624.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17058" checksum="05EC4180A03DFB69" modified="2020-12-02" version="1">MVSLDGGDVSDFIGVVGSTAEEEQDDVFDDILISSLSEPSPESEAISSPGWTYSMQDLTKVDLYDTNGSLLFTVREKSSCTFGNLAENLHTKIREKNQSLQCFTFKETNTASLDPNQELGFQYHRIVVLPATDGDQWGDWRIDDKGIVELRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H890</accession>
    <name>A0A6P8H890_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 151 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116289862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552659.1">
        <property type="nucleotide sequence ID" value="XM_031696799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289862"/>
    <dbReference type="KEGG" id="aten:116289862"/>
    <dbReference type="InParanoid" id="A0A6P8H890"/>
    <dbReference type="OrthoDB" id="190434at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14857">
        <property type="entry name" value="TMEM151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552659.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29704" checksum="193F522887E72823" modified="2020-12-02" version="1">MCEDWMVECPVCSVILNVAVVVSFLLICWCAADDTVYNGVLPPQKLVALPVVLFFLLYACYMTECYYASSRKLLXKVLRQQTIVQFIERLQATSPEIHFSAVCWHNEPKSRMVPVIDRRGKTRMQNEXYREKVVTLTDTEKFKYSLAVITFTKSFQFTDPPSKSLFINLSCGFQARNRHIDKHMDFEEAMTLEGFSDHVIAYVDFDRKESWMNIWFYWLFSALLMSWLFRWMLKRRTLTSELKIVKEIQVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H957</accession>
    <name>A0A6P8H957_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116290110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031552959.1">
        <property type="nucleotide sequence ID" value="XM_031697099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H957"/>
    <dbReference type="GeneID" id="116290110"/>
    <dbReference type="KEGG" id="aten:116290110"/>
    <dbReference type="InParanoid" id="A0A6P8H957"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="413"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552959.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="61960" checksum="9A4B7C82069410C1" modified="2020-12-02" version="1">MGRKLVQILVVFGVIPIVISEVYTALTHMKGLIRMEKTLTRELEHFLASHPKAPAEFHRLAIEVKTQTSDIKNDLERFLGHPLNAFLLIRRYRKQWKELEEYLRKNDDESDLFQILEAFSTGFPTDEDVLGCVRAIMRIQEVYRISAKQIADGKLSNKTVTPQLNAEHCFEIGFAYYQWENYAQAYGWLIEGMTRLEKPFEYNGPLRRVQVLEFLSWTEYMTDRLIDALKHALELLQLDPENDYAGRNIEFLTNEVQKANEKGGPYVRQEAFFKKPRKKKEEYMKVYERLCRGISLKSQAQLGRLKCYYETKLHPMLKLRPLKVEMINEDPYIVMLRDVMYDHEIEYIKKTAAPLLNRATVTNSETGDLEFADYRVSKSGWLEDFTHDNDEGILKRINRRTSIITGLKTDNTSAEALQIVNYGTAGHYEPHFDHATEPYSAIMRLGMGNRIATLLFYMSDVESGGSTVFIETEAIARPSKGDAVFWYNLRKSGEGDSLTQHAGCPVVVGSKWVCNKWIHEMGQEFRRPCDLTIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAI2</accession>
    <name>A0A6P8HAI2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116290547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116290547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031553464.1">
        <property type="nucleotide sequence ID" value="XM_031697604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290547"/>
    <dbReference type="KEGG" id="aten:116290547"/>
    <dbReference type="InParanoid" id="A0A6P8HAI2"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF39">
        <property type="entry name" value="E2F TRANSCRIPTION FACTOR CC-MB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031553464.1"/>
        </source>
    </evidence>
    <sequence length="808" mass="91860" checksum="2653A4832E057BA2" modified="2020-12-02" version="1">MASTSXKGTSVFRNFVTYIQSDKQSPRNLVLVDVSFLTDDFLHNNPNGTYPSLLPCPYTRLRKAPLKNIKGNNNEVNVSCKTHISSKRDCENAASYFGRPDENLGSRKCQQDHYPDICSFVRTESKGYKVKCDASICKGKEVSIAAIDENIGIIIKWQRITPFXASKVNEFVQRKMSQSHTFSFIKCGPILQALIFPPKIKRNKTVDEQKKMNVNIIVLDCVSRPHFFRVMRESVKAMRKVIYDQSINXTVLDYELFQSLSMHTFDNIRPLFSGIVQGNEDFSSASVSLEPLGIHVLSNEFKKYGYQTMFQEDLCWHDSWGIMLNNLIRTNGEINEKRFQIFKDTVKEHNLDHIGITHFSCEVINQYGYTNHYDRPSQVCLNGQFYNSYFLKYLKTMIQEIQHDEKAAPLLLYQHFNSGHTHTGTRIQNDDDALADFILNIARDPNSLTIILSDHGHTRTPYGQTEEGKRELYHPLLFMIVPHYVAGLLGKQRMEALVANQKRILTTLDINKALMSLHDEKTKFSTDHXVNGIFSKIPANRACGDLPLMPLARCQCEGSDSKVLDNSNTHRWMAEFALGTLNNIIQEQYFKGINTSTPNPVKGFGNCVRYVGTSFRNIIQSTSGTMTTMDLHIDAKEVGLKEDEITRAAVEFNGKTLSLKSYERQTLYNKFKNCDDKSVDLKXCICDKNKAPSESGKPRVLETAKMKEFVSSPMFGTESKIKDLHGGCLFQITRQHSSKISVVYEVANSCEGKTFKISVEGSLEYVFVSRPLPFQITVEPNSIYFMFSAVRQILNHSHMDITITAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAJ2</accession>
    <name>A0A6P8HAJ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289832 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552621.1">
        <property type="nucleotide sequence ID" value="XM_031696761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAJ2"/>
    <dbReference type="GeneID" id="116289832"/>
    <dbReference type="KEGG" id="aten:116289832"/>
    <dbReference type="InParanoid" id="A0A6P8HAJ2"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552621.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19242" checksum="DC760423AD51A5E1" modified="2020-12-02" version="1">MPLVAQYTMTSRSQEDTPRRKVLLAVDHSEHTLRAFNWYLDDLHKDDSILYILHCQELPALTLPPHAYATRIYEDWLEEARKTEAKNKDLLHSLKQKCESRNVKCELFLEHASSAGDALCQFIKERKPNYVVIGSRGQGMVRRTVLGSVSDFVIHHSAVPVCVCPPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB13</accession>
    <name>A0A6P8HB13_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289984</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552806.1">
        <property type="nucleotide sequence ID" value="XM_031696946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HB13"/>
    <dbReference type="GeneID" id="116289984"/>
    <dbReference type="KEGG" id="aten:116289984"/>
    <dbReference type="InParanoid" id="A0A6P8HB13"/>
    <dbReference type="OrthoDB" id="5973086at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028484637" evidence="2">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552806.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19456" checksum="18FFA35DD44D207A" modified="2020-12-02" version="1">MGIKLQLTVVILCALFTSLSALYSEWNSWGPCSKSCNGEQNRTRSCHTITLQPCEGKIQKRNCNASGCYPSSEFIITSAVLGTLILLLLVVLIVIIIKTRNTSRTLTKKKNRENVLDFENTASNGRKDNSKNFNKNIAQRTSSATPSTVSQVTYLQTDAPAGTVFKPWGQKDCDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBB9</accession>
    <name>A0A6P8HBB9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosducin-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552911.1">
        <property type="nucleotide sequence ID" value="XM_031697051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBB9"/>
    <dbReference type="FunCoup" id="A0A6P8HBB9">
        <property type="interactions" value="2804"/>
    </dbReference>
    <dbReference type="GeneID" id="116290070"/>
    <dbReference type="KEGG" id="aten:116290070"/>
    <dbReference type="InParanoid" id="A0A6P8HBB9"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="49"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552911.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27841" checksum="5C4975789EECFE4D" modified="2020-12-02" version="1">MQDPNEDTEWNDALRRHGILPEKPKEAEVTEDDIVNLVEKTIHDRFKDTKPIEDMSLEELEEMEDEADERAMLEYRKQRLAELNAYQKASVFGDVREITAQDYVTEVNKAGEGVWVVLHLYKTGVPLCTLINQFISQLARKFPATKFIKSISTLCIQNYPDKNLPTIFVYYNGDLKKQWIGPFSFGGMNLKIDVLEWMLSEAGAVVTDLEEDPRKKHKIHDVMTSAIRQRPMDSDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBK2</accession>
    <name>A0A6P8HBK2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 205-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553001.1">
        <property type="nucleotide sequence ID" value="XM_031697141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBK2"/>
    <dbReference type="FunCoup" id="A0A6P8HBK2">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="GeneID" id="116290146"/>
    <dbReference type="KEGG" id="aten:116290146"/>
    <dbReference type="InParanoid" id="A0A6P8HBK2"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553001.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26555" checksum="60D8746B8F0BF95A" modified="2020-12-02" version="1">MSSNQVLSSKPAQNQDSKLQKRVMTLRVCPQLTTFVVLMLALSLSSRISEEVRRGSILSTVTRFTHLFAFGTWLGIQFWATFIAGVTMYFNMGRHAFGELQSKLFPKYFFSGACLTAITLATYCLIHPIQHWEGKDKIQSLGLLVSLICCMMNYMYLEPTTTRLMDKRYAFEKERGYGQEIGPIPDNKLKNDEEYLKITKSFACVHGFSSMANLMSYAGCLLHLWYLATQVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC59</accession>
    <name>A0A6P8HC59_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor NUBP2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116291031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. Interacts with NUBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554014.1">
        <property type="nucleotide sequence ID" value="XM_031698154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC59"/>
    <dbReference type="FunCoup" id="A0A6P8HC59">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="GeneID" id="116291031"/>
    <dbReference type="KEGG" id="aten:116291031"/>
    <dbReference type="InParanoid" id="A0A6P8HC59"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000796">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031554014.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30724" checksum="D540146A3C4EF3AF" modified="2020-12-02" version="1">MWSAASRTKNNMADNIEAPDGLKLVKHVILVLSGKGGVGKSTVATQLSWALYNKGYKVGLLDVDLCGPSIPRMMNVENHDVHQCSDGWVPVYTSPDQRLGVMSIGFLLQDKNDAIVWRGPKKNAMIKQFLSDVCWGELDYLIIDTPPGTSDEHITVIENLKQYNPDGAVLVTTPQGMAITDVRREVTFCHKTKIPVLGIIENMSGFACPHCSECTNVFSKGGGEGLAKECKVPFLGCIPLDPNLTQNIEAGKSFTNLMGSSPTVEALNSIITVMFDKINVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDQ4</accession>
    <name>A0A6P8HDQ4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116288103</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031550700.1">
        <property type="nucleotide sequence ID" value="XM_031694840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288103"/>
    <dbReference type="KEGG" id="aten:116288103"/>
    <dbReference type="InParanoid" id="A0A6P8HDQ4"/>
    <dbReference type="OrthoDB" id="5953041at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="15">
        <location>
            <begin position="100"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031550700.1"/>
        </source>
    </evidence>
    <sequence length="672" mass="77608" checksum="F88ED7D280F7BB7D" modified="2020-12-02" version="1">MVYGSFRGIASKLFCIGVVWILFLFIVHLILDFEQSTKYFKPVASKSQGHPIFSLDDLDFIEEDDFREKREKCDIPFDDSYPDCKIQVERLKETWSKDTCFQDFDVDGSDCSILIYLSEVESWCPRLFWRRXMKKKARRKQKVAKFQAHFTDDMDLLMTLLEKPELKSLATRAFNMWRHWKSGYRFMKKDEEGKERNLKKILIYIGTLANSPVNTSTSQDLSDDLVQWSDLITSLFILGHKLTISNDKQDLISLLTTQGFKRRCNNEENLFDLVYTDHVGMRQLMTSQPEIRDKVWSRYKCKFRVLDAFGTDAEFNYANYNESFLPGGRSTLGNLELSLRQFMTKFPMSPDNSFLGFVAGSHIEKRPFLKKKKRIVIYGDESSIYKNHTFPLYEFASKFMRVHAAVVGNDQCFYFQNKQATESSLPSYVINHGVLKSEDLDRLITKSKAVIGLGKPSEGVLPLVAVGKGCVFINPKYDSPKYRLNSDFLKDKPSLRQLASQHPYLEKFVGKPHVITLDLNNDTEFKEAIRRIAKTKVRTYIPFEFTAEGFLQRINAYVENQDFCHQSDWPTVLELQIKIGTTGQSCHDVCSEKGLICEPEYFNAVNSTKIHGCRITHSVESVFAPAKEANSTNCITQSQPLLFSCLRASPRYRRVCPCRTYKTGQRALCEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEJ7</accession>
    <name>A0A6P8HEJ7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116288405</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FKBP-type PPIase family. FKBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031551052.1">
        <property type="nucleotide sequence ID" value="XM_031695192.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HEJ7">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="GeneID" id="116288405"/>
    <dbReference type="KEGG" id="aten:116288405"/>
    <dbReference type="InParanoid" id="A0A6P8HEJ7"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000016">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028206276" description="peptidylprolyl isomerase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551052.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15938" checksum="18932386EB4EDF90" modified="2020-12-02" version="1">MRILTVSLVVVILALFVLETKXDKKAKTKKLQIGIKKRIKDCKQKSAKGDSLHMHYTGKLEDGTEFDSSIPRGEPFIFTLGTGQVIKGWDQGLLNMCEGEKRKLVIPSDMGYGDRGAPPKIPGGATLIFEVELLKIVKQNKSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEJ8</accession>
    <name>A0A6P8HEJ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554849.1">
        <property type="nucleotide sequence ID" value="XM_031698989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEJ8"/>
    <dbReference type="GeneID" id="116291781"/>
    <dbReference type="KEGG" id="aten:116291781"/>
    <dbReference type="InParanoid" id="A0A6P8HEJ8"/>
    <dbReference type="OrthoDB" id="8029257at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554849.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15120" checksum="21775F3BEE37179D" modified="2020-12-02" version="1">MKCPGKFKAQLHASSMGKTANEEIYVVKNLERSLLGRKAAMVLKLIMQVDNVNKNARVFEKYPELFTGLGRMKDEHSYSISLKEDVKPFAVTVPRKVPLPLYKETKTKKELEKIRKQESCRKSRDRPNGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF46</accession>
    <name>A0A6P8HF46_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myelin regulatory factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555034.1">
        <property type="nucleotide sequence ID" value="XM_031699174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HF46"/>
    <dbReference type="FunCoup" id="A0A6P8HF46">
        <property type="interactions" value="1167"/>
    </dbReference>
    <dbReference type="GeneID" id="116291941"/>
    <dbReference type="KEGG" id="aten:116291941"/>
    <dbReference type="InParanoid" id="A0A6P8HF46"/>
    <dbReference type="OrthoDB" id="27041at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="10">
        <location>
            <begin position="81"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="11">
        <location>
            <begin position="397"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="6">
        <location>
            <begin position="81"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="709"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555034.1"/>
        </source>
    </evidence>
    <sequence length="839" mass="93575" checksum="C413E143095189A4" modified="2020-12-02" version="1">MFCTGPTYEAAILHNRQDPIDIPRLPLKSEPLTPPRSVGSDSPMDERGHMVADSTIDTAKFSSLLSQQPFLSNGLEDPSNPPPVYLVQNTRCEPEPRRKRRKTEPDMMMSDSPVGLATIKNEPGCLDDVFIDTDSISSSLSPDVYSGQISPDADSTSYQCLKWLDFKKPQWNDLYDESCNITPTLDFHVDADKGFNFSFADDAFVCQKKNHFQITVTVKTPITPKYIKVKDAFKPIEKFKLHLFGVKVESVNSTIKVEQSQADRSKRPYDPAIIPVSSKDVSRITIGRLHFSETTSNNMRKKGKPNPDQRYFMLAVALHAYTKNENQLVCATVSDRIIVRASNPGQFENDVEVVWSRGQSPDSVFRVGRVGINTDKPNESLSVHGNVKLTGRVLMPSDKRVKENITEVDSSEQLKNVSRMKLYRYSYSQEYLDVAGLATDPETGVIAQEVKEVLPEAVKESDDVTLSDGKMIEKFLVVNKERIFMENVGAVKELCKLTDKLEIRINELEKVNKKLQSRRRADTASSCFSNLSRASSFSRNSTRDKKSNNKDSPLTTEKKPQCNGQKHGYRCNKHNTHQQEVVLEEQGWCTPRFMQFLIIVLILVMCLSIGAMATLYVMQDSKQNGYPGDASEAFIKNTPGTTTIFLLNTTTTPRGSSVTTRSTTKDPSSSPMVTESTTEARNTEEGRTTGIHRFSVHPAVPTVVNTHNTTINAKSGKPPPLHPVNTESQQHSPTPTPSKPVCQCCSRTAEKCDSIPYKLLANKPVYSEMSNALPPVKIQGTAKAQDMKLRIMEKNYDLKCDSCSSVNESYFIPISSTIPLKPVTLEINSTGDTLVLLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG87</accession>
    <name>A0A6P8HG87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Proprotein convertase subtilisin/kexin type 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116290997</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553978.1">
        <property type="nucleotide sequence ID" value="XM_031698118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HG87"/>
    <dbReference type="FunCoup" id="A0A6P8HG87">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="GeneID" id="116290997"/>
    <dbReference type="KEGG" id="aten:116290997"/>
    <dbReference type="InParanoid" id="A0A6P8HG87"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF28">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027606175" evidence="17">
        <location>
            <begin position="27"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="483"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="724"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="856"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="856"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12 13">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031553978.1"/>
        </source>
    </evidence>
    <sequence length="905" mass="101169" checksum="F8104CB9A90CE362" modified="2020-12-02" version="1">MLIKLQIWRIFTHFVAVVLISCFVESQFEENFIASSSFLPIYNDSAAMASSSWAVRIPFYSHMDEKDLHFLADKIAHEAGLYNMGQIGGLKRHYLFYHKSFKNDSKQHSTETARIRHSVTELLGNHPHVEWFKQEVVRKRYKRGLQFQDQYFPNQWHLDNLRYVGNDINVTGVWENNITGQGVVVSVIDDGVEWTNPDILDNYSSEGSWDINSNDPDPMPRADDAGLNHHGTRCAGEIAAVPNTYCAVGVAYGAKVSGVRILDGPMTDSLEAMAFNTKLHINDIYSCSWGPDDNGKTVDGPHQLAQAALAHGVLAGRHGYGSIFVVASGNGGHFKDNCNFDGYANSIYTVTIGAVDEVGDMPYYAEHCAAMLAVTYSSGQGMQRNIVTTDWRLGTGTGCTDKHTGTSAAAPLAAGMIALMMQARPCLTWRDVQHVIAMSAFKHSVDDDDYHTNNAGYHHSHKYGFGVLDSWRLVTTAQMWKSVPWMTSWSSPVIHVNRAIPSTNKMTESYRVTREQVAEVVTLEHVTVTVNLRHRYRGNLIVKLVSPHGTPSMLATARRHDRSPEGFVDWTFSTVRCWGETPEGVWTLIVIDNGNDHARGYLMDWKITLYGSALSPADIKQRRSIMEEGISGKYLHTDKAPPCPPPPSSVKSQEIMSERMLKVLLLFSGFCFLIAIYYVLDVVFDNEGLGPPQPVEEKVENKEPSPLIPAKLAEEDWKRLSNLLESGEKNTRPSSTNQTSQRKGFQSSPSYSSNSNQNNPALPSQPSSTVIPTDTVVPIESKTSSSRTFFGKRRVLSPSDEVRRVKDFEKRLRYAMEQSLKLQTKQLKDIDELENELQQATEESLIAHALEQRFYNSISHTPPPESTNINKPTKIRQSNASAGRSIRKPIKGILKKSKSYLSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGF1</accession>
    <name>A0A6P8HGF1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Elastase-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292337</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555484.1">
        <property type="nucleotide sequence ID" value="XM_031699624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGF1"/>
    <dbReference type="FunCoup" id="A0A6P8HGF1">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="GeneID" id="116292337"/>
    <dbReference type="KEGG" id="aten:116292337"/>
    <dbReference type="InParanoid" id="A0A6P8HGF1"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028295669" evidence="9">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="46"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555484.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38545" checksum="18FFDB06398EEF06" modified="2020-12-02" version="1">MAAKCFLFRIFFFIWVAEMCKAYPKNVKGFLPRVSKPQCETPVKRIIGGEIATPNQWPWQAQILRWKKENNSYVHRCGGSLFNLEWVVTAAHCVFDQEVSALKVRLGEYQRNVTDISEQDFTVSAVHLHSRFLADSEYAYDIAILRLNRTVKTSCAVYPICLPRLYDQVPIGKECFLTGWGMNEFGGDKSNFLRLVKLPVVSYQDCYDRNKKKHRVDRFSSICVGTVDGNQTQSGCHGDSGGPLACQDDNGRWELQGVVSWGDHHCGNAYYSVFTRVSSFVDWIGQKMASAPLQKTVKCVDTHYYCKEWKEKGWCDQRYFEHMLKGYYCKKTCGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGU7</accession>
    <name>A0A6P8HGU7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC116289065</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC116289065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551816.1">
        <property type="nucleotide sequence ID" value="XM_031695956.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551817.1">
        <property type="nucleotide sequence ID" value="XM_031695957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGU7"/>
    <dbReference type="GeneID" id="116289065"/>
    <dbReference type="KEGG" id="aten:116289065"/>
    <dbReference type="OrthoDB" id="5983632at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031551816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551817.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15677" checksum="B7F56F866028935C" modified="2020-12-02" version="1">MVHHPEEVWMRYGYSREEPWKNVKGWNGDQLENLRRLYDGPIRVKDAKVKDLKKLAEKHLPPEKRGFYMNLNNGAVEEDGLDNFMIAKFTEFAGLQHLVDNQVSLLEEERKAPLTKKELKQMMNSRTKLLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIR0</accession>
    <name>A0A6P8HIR0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031554763.1">
        <property type="nucleotide sequence ID" value="XM_031698903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIR0"/>
    <dbReference type="FunCoup" id="A0A6P8HIR0">
        <property type="interactions" value="2549"/>
    </dbReference>
    <dbReference type="GeneID" id="116291695"/>
    <dbReference type="KEGG" id="aten:116291695"/>
    <dbReference type="InParanoid" id="A0A6P8HIR0"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031554763.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25367" checksum="81489C137CD0243B" modified="2020-12-02" version="1">MTSMTTSFIRMVHTCRGAFICLEGCDRAGKSTQSKLLVDYIRSLGSSVEQMRFPDRSTAIGKCIDSYLTNKTDLDDHAIHLLFSANRWEAVPTIKNLLNNGTTIVTDRYAYSGVAFTAAKEGFTLEWCKNPDRGLPSPDLVIYLDVSSIKTSERSDYGQERYENNDFQNKVSARYLELKASDWKVIDASKSIEEIHEDIKQAVLKVQERVTDKREPIHKLWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK77</accession>
    <name>A0A6P8HK77_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116290231</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553097.1">
        <property type="nucleotide sequence ID" value="XM_031697237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK77"/>
    <dbReference type="GeneID" id="116290231"/>
    <dbReference type="KEGG" id="aten:116290231"/>
    <dbReference type="InParanoid" id="A0A6P8HK77"/>
    <dbReference type="OrthoDB" id="5945172at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF120">
        <property type="entry name" value="HETEROGLYCAN GLUCOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="49"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="305"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="683"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553097.1"/>
        </source>
    </evidence>
    <sequence length="960" mass="110291" checksum="24A8BF569C6AD15E" modified="2020-12-02" version="1">MAYRYVPPDEFTPESRVTWKPLNTVTSWKQEEEGIVDKFTLNFDSGHKLYIYFFSHTSFRVRFNPDPNAPYVKSRSPATQVERIEAHEIKVEEKNKVLIIETNRIKVKVNLTKYALSVYRGNQLIHADPDDYNLVYIPKEAGGEAVANFKMAPKNACYFGFGEKAGVTLDKRRVPKQHFYGNFGGDNKEKLGSALTFFNYDNFGYAAPDLTPEGEVQGPLNPNGPLYQSSPFLIEHNPSPTGDFSGPSYAYGILLDNTSQTYINLRQGDQYYIGALHGELDYYFFAGDHVAEVLNEFTQLTGRTKLKPKHVFGYHQGGYGWNYNNKWKLMEVALKYRQWKIPIDGLHVDVDLQDSYRTFTHSKKKFPNPKGMFAALHDWGFKMSTNITPIISCNADEEGEHSPYKALDSGKQKNAFVRNTREDGSGTHDFYIGNVNYGRGHLTWGHYPDLGRHDVQEWWGEQYRDLLDWGLDFVWQDMTTPAMKASIHQDPCPFLSFPMDVMLSDNEETRYDDHSTHLEDKKPFAKIRCLYNYNLCKATYKGLEKLQPDRRHFIIARGGFVGVHRYAGLWTGDSTSNWEFVRINIPLILNIGLSGQAISGCDIGGFCAAFQGQIVEPEMLVRWTIMGAFLPWFRNHYDNYYKPYQEPYRYSEPVPSICRKYIELRYRLIQYIYDAMFGNTQTGKPICRPIFMDEVKVGVYNNDPAADDDHGWGYYGYVTNRMDDQFFLGKDLLVCPIVNPGQTNRPVYLPSGSKWYHFKDNKKPLDAPVMGGVEFDFYAPWDKMGSDNCALYVREGAIIPTRELEQYIGELYSQGKDNPLTFNIYPGRGDKYTLYLDDDGVTNAAEKELKYRIVDVSHEETHNQRRVVFSRKHDKFTPRETFYYVALLASGEPSRITVNGEAVPKENGVNNDEMAESLAGRGYNSYYYNFSLNTTFIKVFDVKKEIVVVADFSPVSAMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLK8</accession>
    <name>A0A6P8HLK8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Helicase-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557289.1">
        <property type="nucleotide sequence ID" value="XM_031701429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLK8"/>
    <dbReference type="GeneID" id="116293927"/>
    <dbReference type="KEGG" id="aten:116293927"/>
    <dbReference type="InParanoid" id="A0A6P8HLK8"/>
    <dbReference type="OrthoDB" id="5979605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="203"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557289.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42461" checksum="4398B215F8083F21" modified="2020-12-02" version="1">RIRSMMHIVAMRRTKSQKVNGKPLVELPDRQLFIQPVELSLEERKLYDSMANEGKLLIGNYVRSEALFQNYADVLAILMRLRQLCCHPRLCASALALLSESSKSGTPEELRQRLIASLMAVLATGVDEECPVCLDSLVNPVITHCAHVFCRPCIENVIKTTDHHQGRCPLCRGDIKTNQLVEVPNEVEECGSADGEKWQSSSKVDCLMAKLVELRNKDPTIKSLVISQFTSLLSLIEVPLNAQKFSYVRLDGSMSQARRAEVIDAFNKSNPDSPTVFLLSLKAGGVGLNLTAACRVFLLDPAWNPAAEEQCFDRCHRLGQTRDVIITKFVVKDSVEERMLDLQKKKRELMVEAFKKKTSVEDRRKQRINEIKALIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM82</accession>
    <name>A0A6P8HM82_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC116293525</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116293525</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556825.1">
        <property type="nucleotide sequence ID" value="XM_031700965.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556826.1">
        <property type="nucleotide sequence ID" value="XM_031700966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HM82"/>
    <dbReference type="GeneID" id="116293525"/>
    <dbReference type="KEGG" id="aten:116293525"/>
    <dbReference type="OrthoDB" id="10277183at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653060" evidence="5">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="6">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="7">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556826.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37249" checksum="243D3E6ED5638DB3" modified="2020-12-02" version="1">MKSQLVFVFILFLLKHKVTYATMWPTKQYSEKDVYLQGFTLESFTVDKVFDCHMKCEDHILCTSINIILTENKCELKYSTKAEHPANFTIRPNTIYMEVRDYIKAPGSGKEKPVVSCSWWKKIEQNAKSGVYWITLNEPIKAFQSSAFQVFCEMITDGGGWTLVYSYTFTRYSTFKSTSNAVTPIPNWPVAWSPMGWSPQSTTTPLSESSYSAMEFKLWKNFGTEYLLKSSITNWVACVEGTGSLVRWVAGSLTCRVVNAITSPCTDVAPNKLVLLPCGPSYNKDDKFQFLLDGSSTPDCWPAHDPCGTSPFGSSNHKTNVANPSGTVYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMQ0</accession>
    <name>A0A6P8HMQ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116293045</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556298.1">
        <property type="nucleotide sequence ID" value="XM_031700438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMQ0"/>
    <dbReference type="GeneID" id="116293045"/>
    <dbReference type="KEGG" id="aten:116293045"/>
    <dbReference type="InParanoid" id="A0A6P8HMQ0"/>
    <dbReference type="OrthoDB" id="5976428at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF28">
        <property type="entry name" value="APOLIPOPROTEIN L, 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05461">
        <property type="entry name" value="ApoL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556298.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40258" checksum="705213EA2BAD1348" modified="2020-12-02" version="1">MRQLCGKTVPCRFSGFLFVLEIVKYDFQSQKRKVCEDFHHWIPVRRRTIRELEEMNLDEMTAALDELHRKANIATAAGASTSVLATGLVVGGFIGSFFTFGATIPIMIAGGSIAAAGGLTTFGAKMSEIVVSKTNINKVEDAIAEDKEESENLRKSIEKLNRLIERNVQRIFDNKEDLDELSDEASPDAILNVMSHFEDITGMRIMETDQLHPVKSSARAVGAVLAATSSGVTAGTAGARIGTAVFDTLSVASRATHVAGFVASVLSLPIDAYFLVTSVRALRNRSPSEVAEKIRDIQNKMVCPLESEIHLLIEEYVKSKVAEVVNAHFEGKPREEFEMLDDIDTLLANDELNNAGTLSFDCQSNNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMS3</accession>
    <name>A0A6P8HMS3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293674</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557001.1">
        <property type="nucleotide sequence ID" value="XM_031701141.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116293674"/>
    <dbReference type="InParanoid" id="A0A6P8HMS3"/>
    <dbReference type="OrthoDB" id="5989103at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040564">
        <property type="entry name" value="CxC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104:SF2">
        <property type="entry name" value="CXC3 LIKE CYSTEINE CLUSTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104">
        <property type="entry name" value="SI:DKEY-29D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18804">
        <property type="entry name" value="CxC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC3 like cysteine cluster" evidence="1">
        <location>
            <begin position="198"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557001.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="74320" checksum="EE709B1086EEFD6D" modified="2020-12-02" version="1">MATKKKESTSDGEDDLLAEAEALLDKLQPKKPRKDCHFEFHIKPSGLRESKYTYRPRFKSSLDPASNDHDHHESLEETIKRCQEIVDSLPKCHQTWDGRMNSLNENWDNCRPQIMEAVVAEEATEKQLCCLCLQNTCKIRCYSCHGRRFCTACDLIAHEHNAFHDRDVLVNGFFQAVPPTTSVNDNGDLVTINKSPSFFKPSCCSFCTDVNLEECFDSDSNCILIIVNEKGRFDFKKPSFRCRNCGKDTLSLSFSTIIHCGYWPGSPNDPNYLFHQDLFFLWDSLQKRMPGTSESSFIKGLEDFSFSKARAPSINSTTFTRSFRKWKFCQHELSLLQKLDWMKCPPCAVNQXSCHVDGNMKLYHYKRSGRTRTIIPVIIWGGRWQNGSAWTTGEEVXQINSYMSRCGNTTKYMLPECRDELLTEHALTWNRRKIFKMVDSLYQRYVRAVKMKSESSNALHKALQEVDFDVQQTQIDTWKNEVIQNAKETQMIHNYSERKELASFERQIEMTHFSIVQTTMSIGKLAATSKQRTRLRKNMLNHKSKLKSLVDEYNTLVDEKKIGSQVALEDVEKGNFTWDSSLGETPIRVKARLVDLSERSQRWDEEIQLLLLEMRNFLSFYTDNKVPQVMKEIAQLREKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN07</accession>
    <name>A0A6P8HN07_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein DDB_G0281931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557091.1">
        <property type="nucleotide sequence ID" value="XM_031701231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HN07"/>
    <dbReference type="GeneID" id="116293764"/>
    <dbReference type="KEGG" id="aten:116293764"/>
    <dbReference type="InParanoid" id="A0A6P8HN07"/>
    <dbReference type="OrthoDB" id="2151624at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027864811" evidence="3">
        <location>
            <begin position="18"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557091.1"/>
        </source>
    </evidence>
    <sequence length="1077" mass="122179" checksum="D99F66F7FCA7FB23" modified="2020-12-02" version="1">MSTKVLMVAVLIKLLCAIECSSNSSIIEQWEVLMSIYNSTNGEQWLKKDFWNCSGNQVNCRYCFWYGITCDLYSNVTAIVLMDNNLTGSLPPMLWKLRHLEKLVLKSNKNLGGKLEDFIYGNMTKLKVIDLSFCGFEGAIPEEISLLTNLEELRLCSQRGTRKLNGSIPRGIAKLTKLRVLGLGENTLTVPSPSRLFGGLTKLEVLDLEDVTIKSTFDVFCNLTGVKSMNLSKTGLHGELPLNLGKRFPKMEELLLPGNYLSGSIPNSIGMITNLTRLSLANNNLSGVIPGNITLATKLSFIDLTVNNLSSIHNESLLLSHDLEILLLSDNPNLNVSFAQFLQSPDTKTNSGPAKLKVLIISNCSFYGKIPKSIWSFGNLIYVNARYNKLSGYLPEVLAPMYTLLHFDVSHNHLEGPIPSTLTRIESLHRLDIRGNHKMTACSECKNYTCCKAVIKQHGLKIDFKYMLHKSHAGNFSCPMAFLRVTNGPVYLDARYYEYMFCKCDPGYYGEGRTCRRCMKGGKCVDTDRHHMIIRKGYWPEPGPKNVTHLHICDDKEDFFTGGRRLTACNPSGNCSCHLTTSSSSTLTTCSNTCLCRKGSIDRLCSRCQKRWYKSGSICRECPSHHHATYIFIGVLVVTLLIFAAALLYLKNRPRLGILVIYGQIIILFFLRFFNVIPAWVFEINVIILLFYLAGIGSSMKGLLKIAVFYLQILDAMLSTYKMWPKEILQSQHYISSLINFNFPGLMCDIPDLYTPTGQFKLLILLPVVCIFIAWLFYCLVWIADRIRATRWNVLSIKYHCLQISVTCLNLTYFPIGLRSIAVLASCRDHSSHMRIAPWIPCNSPTNSFLRTLAWLSTVIYVIGVPLFVFLPLLLRYVRAHKLSKLTKQEKEALDKWLGSIYLPYKEKCRSFCEVYALLRKLLLAFLIGYIPEVSSLQTFFVSMVLAIALIFHLVWQPYQSSLGWLPIENILETIVLVVLQQSFILLRFTTVEKPYKKKVHLLWIIVVVNCMVVLILVVIISVLLAKHAAKSLKNRSRNESSRTNKFKNDLLSYFRSKNSLFKPLLMREDKDTSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN30</accession>
    <name>A0A6P8HN30_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CD97 antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116293132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556388.1">
        <property type="nucleotide sequence ID" value="XM_031700528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HN30"/>
    <dbReference type="GeneID" id="116293132"/>
    <dbReference type="KEGG" id="aten:116293132"/>
    <dbReference type="InParanoid" id="A0A6P8HN30"/>
    <dbReference type="OrthoDB" id="5965914at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000945">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF58">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027789796" evidence="8">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="196"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556388.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="31420" checksum="1665B8D5DCB9FD12" modified="2020-12-02" version="1">MNWLALVLLLCKAHYITCTEQDDYFNKDKGFLFDAFPESILSFPIHTKDIQQQTTQVPEKMECVFACVGVPWCQSMNFQTTAKNNGLHVCELLSTDKHTHPQNMIQNNAFVHFSIQNPCAETPCHNGGTCILQKNRQEYRCQCKKGYDGNNCQNDVDECTAGTDNCHNDATCTNTGGSFTCQCKPGYQGNGVTCTDVDECTVGTHNCHSDATCTNNGGSFTCQCKPGYQGNGVTCTDVNECSTGAHNCPTANTRCLNIVGSFTCQCTTSGYYWNGNTCAVQRDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNB1</accession>
    <name>A0A6P8HNB1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SE-cephalotoxin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556488.1">
        <property type="nucleotide sequence ID" value="XM_031700628.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116293223"/>
    <dbReference type="InParanoid" id="A0A6P8HNB1"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028460314" evidence="7">
        <location>
            <begin position="19"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="10">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556488.1"/>
        </source>
    </evidence>
    <sequence length="941" mass="106623" checksum="655364B2DCA7854B" modified="2020-12-02" version="1">MRCVLWLLLLPFYSDCTAAELDPGEQAKVSTALDTTQFVLSQLAAHVKDEQKALKEATKASKSLKSAELLKKQTKLLKVGKMVGRALKAIQAASAIASFIFTFFMPSDLEVITSLINKRFNEVNAKLDRLDQKLDEMEASIKANSAFNTFLSAWIKWEYKSKNGAKKLSDIRKAMGTKTRRIDQVKLAEEYVKYYENNDLDGNLLNLYRMAALPEGITQRNLITGLEWKGSRYFKVEDRSDPGNVKEYYIVYEDTKSLASCSEIRQAKTLLVLKGCEGCNSDYIYAADNILSHKKCGSSNLQKLVDFQTECKSSRYRYSYWTEKECIKDLKNQIKKMGFLATNVNTNYNPCTTSEKCSGHGQCKQIPFTKTHQCICVSHYGGESCEKRIEFDDTTERLMAQLRKTFNVVNGVPTAVDIFFSIRSLSQKLDLVLLKIKASFAHTNNIIQHSRIIYNVEDIADLYAKLQKDXLSFDRFGQKMDLYLKTITAFQLQNRLKKMILGQGTLDKPGKDIYNSYKLDYLSHNGGGCSGSYNADIKGFRDDLAYLDQALGEALLLHKKWLLETKGTTDALRSQYKREAQEIENVFKXRQKAYNQYWNKYSCGTLGVEGTTISCKHQLSFEGMTMTVSCDKQRQPTPGTVKCRKINGVLKWDSQPKCKFVWGNWRHDWTRCSTNCGGGFKTNYRSCLGTNNVDDCKRDQGGLNYRTTACNTVDCCSAGFGKFRCSNGKCINKNWICDGDNDCGNKDDESRSRCPSYLRSGDTIALKSNARGSSWVSCYCTVNCGVKKCKLRSCPGSTMDSGDWSRCGSETFYIILTYNSESGRAIRNGDGVAFYYGAEHWLSCWGSGNRCRTTICPGRFTYDFNKNCCGEMFWIYAPDRGSNKPIHKGDTVFIKYSYTRGYSWWLSQDDGVIKTRTCPGDSITRDDKSRCSSESWNIIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQI4</accession>
    <name>A0A6P8HQI4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-2(V) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557821.1">
        <property type="nucleotide sequence ID" value="XM_031701961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294368"/>
    <dbReference type="KEGG" id="aten:116294368"/>
    <dbReference type="InParanoid" id="A0A6P8HQI4"/>
    <dbReference type="OrthoDB" id="5975172at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027775860" evidence="2">
        <location>
            <begin position="24"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557821.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="59404" checksum="B540C678AC9A1323" modified="2020-12-02" version="1">MHFRLVVFFLFALFFIRMPTSEGKAKRNIGEPDSXFAEPAPIEGDCPCSKIACVGDKGPKGDKGDVGPEGAQGPKGEQGPIGPKGPQGDKGGIGPRGSTGLTGTPGIIGLPGKAGVNGSRGAVGPRGPQGLTGAQGPXGPEGPQGNEGPKGPPGAVGKQGDKGDKGDKGDKGDKGAPGQNGAKGPKGLPGAQGPRGPEGPQGNEGPEGPKGNTGPPGPRGPQGGTGPIGPKGPRGLKGSPGPQGNQGKPGADGKQGVAGPQGLRGERGPKGTPGSCVTQCADIKMHLLKEIEDLRNFTKAQIKELQRQIDELKPKPTARPTTPPRGKLGSRGNPGRSCKHIKQHDIRARSGKYYVETDTPARQSLVYCYMENLGMCGGGGWTLVMKINGKKQTFRYESPLWTNRVEYQPYYGLSAFGIKESKTAAYWSTPFTRVCIGMRTARYSLKFMRIDYSAKSLYDVIADGKYKATSSGRESWKRLVHGASLQRNCNREGFNIQMRLGSIIAARARIGIASNQENDCGSCDSRIGVGTDGSLCGQDSTNSCGNEARCSPDNGNKSIKTYGYIFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQW3</accession>
    <name>A0A6P8HQW3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116291956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555047.1">
        <property type="nucleotide sequence ID" value="XM_031699187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQW3"/>
    <dbReference type="FunCoup" id="A0A6P8HQW3">
        <property type="interactions" value="2700"/>
    </dbReference>
    <dbReference type="GeneID" id="116291956"/>
    <dbReference type="KEGG" id="aten:116291956"/>
    <dbReference type="InParanoid" id="A0A6P8HQW3"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031555047.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22898" checksum="C0544ADECEC77880" modified="2020-12-02" version="1">MADDLLGDSSYGEETAEDPAADFLAREQDELAELGEDLEGVGNADEGDNFDLLEDSTEPVVNGFGEEENDSSSAQQSAASLLSRQEEPESVKKWREEKAALLEKMDEEEREAIQEWREQAKKELNDWYDRRDEQLGKTKSTNRADEEEFVSDRDDTSKPGHDWEKVCKACDFNPKGTKNNKDVSRMRSIFLQLKQNPLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRC1</accession>
    <name>A0A6P8HRC1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable S-adenosylmethionine-dependent methyltransferase At5g38780 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555180.1">
        <property type="nucleotide sequence ID" value="XM_031699320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRC1"/>
    <dbReference type="GeneID" id="116292085"/>
    <dbReference type="KEGG" id="aten:116292085"/>
    <dbReference type="InParanoid" id="A0A6P8HRC1"/>
    <dbReference type="OrthoDB" id="1890922at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555180.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45810" checksum="8D476713224F6A5A" modified="2020-12-02" version="1">MCTQSTPVGYDHAKVQNSYHTLKDFNMDQKEQFSPHSHIPYGEAGTGFYTDNTLGCYNVIQEATPLVLESIKNTNIKGGSVFTIADYGTADGGTSMPIIYACVKAIREKYGEELAINVIYEDQPVNDFKSLFMRVHGHIPGPPSFLLDFPNVYVTASGTDFYSQCFPKNTVTLGFSATAMHWLRKKPCSITGALHHTMITIPEEGEKFREQAAKDWEQVLLKRADELMPGCQMVLVQFAVDEKGQFLGNTDGNKVSMHHLMRDLWKGFVSEGKITEEEFHHTTFVNYYRTLEEFKKPFETDSPVTKAGLKLVSMETRVVRCPYKQRWMTEKGDPKEHAKRYVPTTRTWSNSTFLSGLSDSRSPEEKAKIVDEFFQRYEDEVAKHPEDHGMDYVHAYIVVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRZ4</accession>
    <name>A0A6P8HRZ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0538 protein C2orf76 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557903.1">
        <property type="nucleotide sequence ID" value="XM_031702043.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HRZ4">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="GeneID" id="116294451"/>
    <dbReference type="KEGG" id="aten:116294451"/>
    <dbReference type="InParanoid" id="A0A6P8HRZ4"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557903.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15411" checksum="A1A52BD9EECF6D59" modified="2020-12-02" version="1">MAAASEESSCATLTVRFIRSFEYRNFRPVVYHQINLEQNTKEFINFITEDIKTRGGIPLPFKKFSYDTLKIQHKAHQAKTNDPIIRTDNDEXLILKEDLTLKDNGVEHETELSFFKKEDYLKYKANPVLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT98</accession>
    <name>A0A6P8HT98_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized skeletal organic matrix protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555862.1">
        <property type="nucleotide sequence ID" value="XM_031700002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT98"/>
    <dbReference type="GeneID" id="116292650"/>
    <dbReference type="KEGG" id="aten:116292650"/>
    <dbReference type="InParanoid" id="A0A6P8HT98"/>
    <dbReference type="OrthoDB" id="5975172at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555862.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23842" checksum="523E60E24F190C07" modified="2020-12-02" version="1">MAYCHMDELPNCGGGGWTLTMKINGSKNTFDYNSFYWTNRQALKAENGLGLEDKESKLPTYWSTPLTKICLGMKMKTNSDIKWLKLELKQRADSLYDVMTTGNPTQPYTLLGVEKWKDTFMPRIRYRFNNPREGVNATFYDRTGRVRVKLGVVYRFGSFLTYLGFGPWGSWHQKYNIDISCGYGREDDTTPHYKKIHAFCYILVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTM6</accession>
    <name>A0A6P8HTM6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitoferrin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial iron transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116292833</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556050.1">
        <property type="nucleotide sequence ID" value="XM_031700190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTM6"/>
    <dbReference type="FunCoup" id="A0A6P8HTM6">
        <property type="interactions" value="2154"/>
    </dbReference>
    <dbReference type="GeneID" id="116292833"/>
    <dbReference type="KEGG" id="aten:116292833"/>
    <dbReference type="InParanoid" id="A0A6P8HTM6"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000127">
        <property type="entry name" value="MC family mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000027">
        <property type="entry name" value="mitoferrin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031556050.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36868" checksum="FE57FAF33EEBE0B4" modified="2020-12-02" version="1">MALTESQEVQGIGVLLSSMEDNDYENLPTERVTIHLMAGGMAGVMEHCVMYPVDCVKTRMQSLKPNPNARYRNLVHALKSMIKTEGLFSPLRGMNVVAIGAGPAHALYFSSYEYVKKTLKGNKKEYSAFSYGVAGVCATVFHDGAMNPVEVIKQRLQMYGSPYRGVIHCAATVLKQEGIKAFYRSYTTQLSMNIPFQTLHFMVYELAREKLNPANTYDPKTHVIAGATAGAVASAITTPLDVAKTLLNTQETEVVALVGKNRGHVVYVSGMYNAFRTIYHMRGISGYFQGLQARVIYQMPSCAICWSVYEFFKYFLHKESDFHEMSATHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUL9</accession>
    <name>A0A6P8HUL9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptor Mth2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556302.1">
        <property type="nucleotide sequence ID" value="XM_031700442.1"/>
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    <dbReference type="KEGG" id="aten:116293047"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
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        <property type="entry name" value="GCR1CAMPR"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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        <location>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556302.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32842" checksum="900C690AEFB9CB09" modified="2020-12-02" version="1">MSLSIIGLVFVLVTYSLFSELRTPPGINLMNLSVSILLAQLLWLLGSGKTDTPMACTVIAVILHYLFLVSFVWTSIIAFDTWRAFSAKGRRPLADSRSQKMKHCLRHMAVGWLPALAYVSFCVVLDSNNFVTISYKSRXCWIGSKWAILYFLAVPVAFSLIFNVVLYVLTLKAIRATATEARAASDHNDSKQSFCIYVRIATLMGFPWAFGFIAPFGCEFFWYPFVLINGLQGVYIAFAFALNKRARSLYRNRFSCTKWSSTVGTTSDSKSTNRSXVPSNTLLHNQYIETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUM3</accession>
    <name>A0A6P8HUM3_ACTTE</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116296266 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116296266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
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        <location>
            <begin position="106"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
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        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="340"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
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        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
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            <begin position="443"/>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031560129.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51439" checksum="BC3CFCA4A3D149C5" modified="2020-12-02" version="1">MEENELINLYGITKVDKMEPKVTEPRNRPPRCIKWLKKYFWEGQSLSMRHETALRESLNDYTPWYKVVLVKHRRVVGLLLPALFFHFFWWGIFIKYDLWHLFLDKYYMSITMIFGSMIAGMTSEGGGAVAYPVMTLAFNIKPSVARDFSLMIQSCGMSAAAITIFFMKVRLEYASLIFCSLGGVAGMIFGLHVIDPVLTPPYKKMCFVCIWFTFAFALFLLNRYRKRTTYKTIPDFKIWKGIVLFLTGFVGGIFSSFAGSGLDICSFSVLTLLFRVTEKTATPTSVILMAGNTLVGFYWRHVMMDGGISKEAWEFMGVCVPIVVFGAPLGSVIGTHFHRLVLAALIYIIDTVALVSAFCLVPLTPWLIGTSVGIIVFGFIFFFIITKVGERLMMNINKRRTGNEELESCEEPDIYENKLDSRPNNVLNEQALHMSPGNEDQAARQSQIEDTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVF2</accession>
    <name>A0A6P8HVF2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
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        <property type="nucleotide sequence ID" value="XM_031700775.1"/>
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        <property type="interactions" value="1139"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:mitochondrial envelope"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="301"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556635.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="64873" checksum="654504EAA40114B6" modified="2020-12-02" version="1">MATVESEFSKQENTDFKHTSAEAVQDNLKEKDNISGDILGTKEFKNKVKESGLENGQGVTATSTTNGVEKTLKEPIPVQQACEDLDIGSKGRTNGVHESAGVSKDNEEETASLEQDSENVNTQYTDEKGGKCVTEKMEFEKERERDSNEKDSQETFKPLLKQRKSPKNGSPDHNHKFFDKESKAEYLKIKSEVTGEAETSESEDDSELPPLEPTHHGSHHSPDAKTKAEYRKIKYEVTGEALTSESEDENVSEEEIKKQAKEAREKDSSSSNEWIDILGNGLLKKRTLLAGKGRDTRPDRGQIVMLRTAGRLGDGTAVDWNQGFEFILGEGEVLQAFDIGVALMELNEVCELVTDARYAYGEQGRVEGDNPVPPNAQISYEIELLAVRDGPDIETMSDEERIEISDKKRELGNDLYTRGDYSAAINCYQRAIKYLMPSSSEKVQGLKVKCWNNLAAAQLKVKAYTAALTSCTNVLNINPDNVKALFRKGKVLAAQGDLQQAVTCVKRAVHLEPTNKTIRSELSSLKQCLSSQNQKEKDMYERMVDGLGGMEKNKSKPSIFPWSLVFGATVIVLGGIVAALYLNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWN7</accession>
    <name>A0A6P8HWN7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116295967</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116295967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559788.1">
        <property type="nucleotide sequence ID" value="XM_031703928.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295967"/>
    <dbReference type="KEGG" id="aten:116295967"/>
    <dbReference type="InParanoid" id="A0A6P8HWN7"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36649">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36649:SF28">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031559788.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30842" checksum="1FDBC10D54E1DE1A" modified="2020-12-02" version="1">MAVPFIGGVMVGGLWVWKYFRGENDGDDPPPTPTPVTTWTTQETYEXTASAFSVITGVKIISQKNVQKLLEQGKEVKALEIKDVFYGHLSSSKTQADDEEQLYYIPDSAYDPQYDYDFTNYKEDDTNCSRGDYPYKRPAGWNRKAVRVNGKYENDIWLGQQGWRDGSSPGEWPVSYHGTKIDNVPSIVAGGYDTNRSVRQWYGPGIYSTPDVKVAEDYAADFNYKGENYKCILLNRVNLKKTKKQETLHGTYFVTPDEDDIRPYGVCIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX39</accession>
    <name>A0A6P8HX39_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FACT complex subunit SSRP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559881.1">
        <property type="nucleotide sequence ID" value="XM_031704021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX39"/>
    <dbReference type="GeneID" id="116296068"/>
    <dbReference type="KEGG" id="aten:116296068"/>
    <dbReference type="InParanoid" id="A0A6P8HX39"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22016">
        <property type="entry name" value="HMG-box_NHP10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031559881.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35309" checksum="644DDE287C48C1B9" modified="2020-12-02" version="1">MADESRVPSGSSGYQSSPTVWKRKYLTLQKRCEQTEQESEQILNRIYHVNKLLRRYRRQRRCIREKLDEHKDDYRNAQPPLQSQLMAEIVSESSLTYMDFDNGGLPVSPGQTSNTTTTSIKKNKSRNPAKQEKEKDPNAPKKPANAFFMFCQQQRNVMQDDQRDAAAAMGHHELTKTLAKEWNNLIDNDKKVYYEMYEKEKERYEREMKNYTSDKGKSKKDKDSSSSKKQKSKAQKTKATLPTATVTQPCPESRSGLVSPTLDPLTQSLIPFNLPLIPSPPLLSNDKDTFQDFSQLSSPPHDSFMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX98</accession>
    <name>A0A6P8HX98_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297019</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561004.1">
        <property type="nucleotide sequence ID" value="XM_031705144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX98"/>
    <dbReference type="GeneID" id="116297019"/>
    <dbReference type="KEGG" id="aten:116297019"/>
    <dbReference type="InParanoid" id="A0A6P8HX98"/>
    <dbReference type="OrthoDB" id="5945008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561004.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16899" checksum="36021A96E7DC2D97" modified="2020-12-02" version="1">MTKRFFIDSRIILAKYRDKNVAILASNSNRAPPAKLSMNSSTSLYLYGLLAVFVLCSVTLTWDTPMFQQYHEHYMSHSTYRGVDVFTEKLNSPTGPEHFMENFYICYGQDGRKTYYKKLDKTYFSNKRFWIITSSGKFIASMKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXG9</accession>
    <name>A0A6P8HXG9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116293993</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557360.1">
        <property type="nucleotide sequence ID" value="XM_031701500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293993"/>
    <dbReference type="KEGG" id="aten:116293993"/>
    <dbReference type="InParanoid" id="A0A6P8HXG9"/>
    <dbReference type="OrthoDB" id="7472380at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557360.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="31945" checksum="CA37BDE7F0EDF935" modified="2020-12-02" version="1">MNGEVTRQTAVGAGVCGVLLLVCGVGCLIPGFVLIANGDANADGLWXGVLLLIAGVLGMVTWWKRHRGVIIGFLVVTICVVIAMFIESIIAGVRYAYYKEKASWYCQKTGFNCKCYQYGYAKSSKDLYCDQSKMDSIIGSLLTIVIFSVIGGIASFTGSIFGCMGTCSTQGQPGTVVVQSPVVMTTTLPGYSVQQPGYSIQQPGYLVQQPGYSVQQPGHQAPQSDYQASKSGYKAPQSGYLAPQSDYQAPQSGHQAPGSDYQAPSSGYQAPQPADIDPQASSSQQQVPDEPPPQYTKHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ49</accession>
    <name>A0A6P8HZ49_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294478</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294479</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294479</name>
        <name evidence="2" type="synonym">LOC116294478</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557939.1">
        <property type="nucleotide sequence ID" value="XM_031702079.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557940.1">
        <property type="nucleotide sequence ID" value="XM_031702080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294479"/>
    <dbReference type="KEGG" id="aten:116294478"/>
    <dbReference type="KEGG" id="aten:116294479"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557940.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16001" checksum="A67322242A53064D" modified="2020-12-02" version="1">MATEVLNGINGCNGHQEERFSLSKVLQSANKLLIHGGNISQWNRTKRKTTPNPSDELCESIXTTLSNCLPVDNNNVENQTHSKTVRSVNNCFVEKIDKEERVHLKISGNNDSVVLKIIKVDYFMFIICIKYISIPLSWWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0S2</accession>
    <name>A0A6P8I0S2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116297105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116297105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561126.1">
        <property type="nucleotide sequence ID" value="XM_031705266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0S2"/>
    <dbReference type="GeneID" id="116297105"/>
    <dbReference type="KEGG" id="aten:116297105"/>
    <dbReference type="InParanoid" id="A0A6P8I0S2"/>
    <dbReference type="OrthoDB" id="5978528at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027896397" evidence="4">
        <location>
            <begin position="21"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031561126.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45725" checksum="B54DA311CC6BB740" modified="2020-12-02" version="1">MWKWLVCLVILFHCAASVEGGSCVPGQKKFDECKRLCVCSEDGTLTQCTRKRKEFTSMSDAERSLYIQTLKTVSTNEIYKKEYDDLITLHIRHFMSGIHNMKHFLTWHRWYLLQYENLLRKVDCTVTVSYWDWSITSGEPWGSETDDLWYAGSTGFGGDGDPTNNYCVSDGPFAEGSWQLVPAANPGCQRRSFYGNPPDSVAVAELLDITAGNFTDFEVSLRINFHDTVHCLIGGTMCSLDSSCAPEFILHHAFIDKIWADWQEKSHEHKTVYFSSITDPLPATYGVMPLEVIDNNALPGGVRVDYLDVNDTETETFVKRIRKLKPERLQEIPRPDFDAINEESLKLFHVSVDEVERAKRKEKRFRPKIKKDRNTLTTRKGKRIGLEEPDLEIAESGQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1K2</accession>
    <name>A0A6P8I1K2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC116295157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC116295157</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558771.1">
        <property type="nucleotide sequence ID" value="XM_031702911.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558772.1">
        <property type="nucleotide sequence ID" value="XM_031702912.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558774.1">
        <property type="nucleotide sequence ID" value="XM_031702914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1K2"/>
    <dbReference type="GeneID" id="116295157"/>
    <dbReference type="KEGG" id="aten:116295157"/>
    <dbReference type="OrthoDB" id="5961837at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558774.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36842" checksum="56BD7245EF453188" modified="2020-12-02" version="1">MSSYLDTSSHESSRRRTTESQKDLPEVQEELKFDEDNVSSRNWFTFMFSCPIQKHMSTIEVFTFWSAILVYFPIGVLSMLDAKTPSMIFRIQSGKYSDGIARISGMQTAVVAFLHIIFSRASPCISSNCIILATVFERIVIVNSLLFLILWQQLVPVQFLLSVMIMDTGLSIIITVLWFHESEVASIGKFFSNIIQVMSLDEPSSHYSSRAVQMLGLVQLFLGSLMVALPNLINQLLYLNANDLDGHSQGLLSVCHMTTAVVGCIHFFSGGADSKAYNIASIFYRVVLSIPFLVVLGMLNQIPFTLMGYFVCLDAISLLVVSLSLCFDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1M4</accession>
    <name>A0A6P8I1M4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116298201</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562444.1">
        <property type="nucleotide sequence ID" value="XM_031706584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298201"/>
    <dbReference type="KEGG" id="aten:116298201"/>
    <dbReference type="InParanoid" id="A0A6P8I1M4"/>
    <dbReference type="OrthoDB" id="5989800at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF31">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028440616" evidence="4">
        <location>
            <begin position="17"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562444.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="65967" checksum="EFFFC4648CC90B77" modified="2020-12-02" version="1">MLYFGLVLLLVSGCAPFSIKQHYAQSPECGHVEGNLLQSPGYPHNYPTNTHCAYAIPLDKNKALKLQFLHFDVEPSVDCSYDYVEVKDQEVSYGKYCGNTLQGDEMVIDDTPFVYIEFHSDKSLTKTGFQIKLEDVDKGHVNGGHEVETVTVANTEALHLKPTTPLDFKTPSKPKAASEYNEKQTTLPSTAETNQPNPFTEFKTSEAIPDIFPTNNRATSDIFPTKDTTPDAFPTNEATHEFFPTNEXTPNVFRTNEKTPDAFPTNEATHEVFPTNEATHEFFPTNEATPNVFRTNEKTPDVFPTNEATPEVFPTNEEGTTDVFPTNEATSDVFPTNKAATDVFPTNEYSQTASETIEMTKAKPTTNERLDRFVTTKESNIPDSSPDKRQMKQGISNDNSEEDPSATTSAELNATDAMINASASSVNESFPTEVPMWNESIVSSNVTGSEGAPTEATETPEGNVDLMSTMYPTLEPEXTSYNPEPEGHVLDKLKLMALLQRIKFAALQMEELLIGKIVEEEVRESRNTKEAKREMDDFRYDIDLGFGRRHKRKVKRDLGTEFIDEIKRIDQERKKKKLSKQATEVKSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2K0</accession>
    <name>A0A6P8I2K0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NLR family CARD domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116297858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562033.1">
        <property type="nucleotide sequence ID" value="XM_031706173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297858"/>
    <dbReference type="KEGG" id="aten:116297858"/>
    <dbReference type="InParanoid" id="A0A6P8I2K0"/>
    <dbReference type="OrthoDB" id="10034282at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00045">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="160"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562033.1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="122245" checksum="C89ABFC1D85673D7" modified="2020-12-02" version="1">MDPYRARLLSISNDITEKEFKDLKFLCKGHLPSGILEKANRPVELLELLEQNGLLGPKNNEYLGALLDKINRNDLTGLLIGEKGTDKTTDRTLVTIQDTLRDHYKNVIGWLQPLTWNSTFRIHIKQIFTNLELIKHNQHGAHGNRQPMSSYEDMFQPKIKRILIEGKAGVGKSTLASEMVYDWATQVNNSSFKLVFLIELRQVNKGIKEAMFDLMFPRDFEVTPDQLYDYVTHHQDEVLFILDGYDEINPSLIPDLHDLXMGKFLKNSTVVVTTRPEKGSKLHWYVDIRVEVTGFTAENMYQFIHRYFKEDTVSAESLISDLEMNPVAENIARLPLTALLICAMWEEMPHVQVLSTMTGLFVELTLCLVKRYYSKEKKENECDPEDISTLEDIPPNLYQSFLTLGEIAINGLLEDQVIFDRKLLEDKCGSREIFELGFLSLERSASRLRPKQLCRFLHRSYQEFLASLWLSDRIKKSFFDPIIYEETVVHVMKCVTAELMTVLFSFTPGLLGNAFEKFFEILISEGGQNAIEEDMKQLFFLVCVQALYESQQGSLAPMLDQSVVKGTIKLKTTEPTPYGIRSLAYFMQNSLDVHTLIFEDSFLSKRNLATLARSLFDIKNLKQLHLINSFATSDAMKVFTDNLSERLPLEKLLVSRSKLLVKDLPEVVHCCSKLHDIEMNYNELSEENFGSLLQALKAVPYLTRICISREKIYHGNVPYLCSLLRGNSHLTHLELNKCVFYSIDDVVLILNSLQHVFSKLTCLXLSGAIVGNKRKVDLEREPIYNVLAEVLPSFESLTHLDLSRNELTKWTDLQQCLGDLTLLRFLNISGNRIADTGVAKLANVLCNLRQLEELHLAWNEITCEGAVSLAANLKFSTNLTVLSLKSNKISDKGASEVFEALSSISSIREILFDNNLISTVAIISLLQHSVNMRNLECLNFKQNLLDELGVLTLVETLGSLPKLKQILIGCPVVRNDSVNEDEAMASASRVENPPATNLKEAESPDDSFTENKKEPRGAHDMYCYKTLSSDVFLCLMHAAHSHPSLEEIYLSMNAVPKNVDAEDFPRLRLWAHYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2P9</accession>
    <name>A0A6P8I2P9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ataxin-7-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116297663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561796.1">
        <property type="nucleotide sequence ID" value="XM_031705936.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I2P9">
        <property type="interactions" value="1755"/>
    </dbReference>
    <dbReference type="GeneID" id="116297663"/>
    <dbReference type="KEGG" id="aten:116297663"/>
    <dbReference type="InParanoid" id="A0A6P8I2P9"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052237">
        <property type="entry name" value="Ataxin-7-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15117">
        <property type="entry name" value="ATAXIN 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15117:SF24">
        <property type="entry name" value="SCA7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="3">
        <location>
            <begin position="183"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031561796.1"/>
        </source>
    </evidence>
    <sequence length="938" mass="101090" checksum="551E4C8D244DAF02" modified="2020-12-02" version="1">MAKIXCHSLLSGSSWSSFEGESSEEEAEAMEVDENNTFGPSEATHLRCEDMNLYGLCPAQEEVRLVICKECKRVVKVSTFSRHCALLHQKVIPPPTPSPELVEDSTTVEILLESEPKTSSPSQAAIKIEKLEIEDSSVKIEEVPLTVPKANHAIISKKIQNAVXNAAMKKSSSTNRKSPRKIIPTREREFDADKHCGVWVEEQKKRCTRSLTCKTHALSLRRAVPGRRKKFDELLAEHKARANCEKEQQQQNLAALKLLESKNTDKNSVLKGNGLITEQTSKPSNDKNSHTLRLNSSEVSEDTSGVPQKNNDGESDGIDDAVSYNDLTSLNYHPKPLATCTFGGRKVGHGAVIFNRRQDHLRCAMLAMVERCLNPSQQRHPSGRPGAAAILHRPSIKTIAQSSNHGLFKGSSTLGEKKNHLGSGRNLSNFLKAPPPPRNRSMKHNNVLHSNHSVKHSVDTSTGFATSRTSNSKNVMDSSTSNITAAASEGSGFLKPDASSQAISDIGNIIASIDGNVSNGQPVVISQTQGINSRTTSGNLPSGVSVSLDSNSCSNLGANSDVSMTGTRTAYTTVYTTINNSSSVNTTQGGNVKEILPAPLSSKVNGVSGGTVSPSNAVVQIAGQLDPSLGKVAVTSTGTQRESPVFFTTQNSGNVQMVTSLPNGTGPSPPPIVTSVKGYPLSFVIQGSSGNKAGTAVAAVANQAAVGFTKGHSLVFNNMGMAQMQQQSGHIIAQQPTSPLKQQQVRQKGKVLLRANSYPXANNKTCGSQGKIPQSASSQQQQQQLSPGQVPSQQKTIIVTSPPPGQQNLYLNHQHIPNTSQPIVQLKQQVEQQQQQLQQITLQQQLQQQQLQQQQLQQHKQINSQFVKQQLPIQPRLAPAPHPPSQSLITQQQISGQNIVIKAADQPLKSPLNSVFVTTDSHQNIQTAVNHKPQSNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I435</accession>
    <name>A0A6P8I435_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562638.1">
        <property type="nucleotide sequence ID" value="XM_031706778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I435"/>
    <dbReference type="FunCoup" id="A0A6P8I435">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="GeneID" id="116298359"/>
    <dbReference type="KEGG" id="aten:116298359"/>
    <dbReference type="InParanoid" id="A0A6P8I435"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19342">
        <property type="entry name" value="Wnt_Wnt10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF98">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028087781" description="Protein Wnt" evidence="9">
        <location>
            <begin position="25"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562638.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40264" checksum="44F31032C1658AFB" modified="2020-12-02" version="1">MELNYVYAFKVVLVLLQIHSKGCCYDIFNSNKQFEDPILNSNTVCKNTPSLNREQMRLCKELPDVVASALQGMQYAVHECQAQFRYRRWNCSSLEMKNRNPMSNPLLKQGFRETAFVHAIASAGITSAVAKACSIGKLATCTCDQSMRGKGDGWQWGGCGDNMKYGAKFSARFLDSRETGRDIHSLMNLHNNLVGRKTVIENSKTKCKCHGMCGSCSVKTCWKTVPNFREVGDLLMEKYDFATLIRVNNRIRSSKVKLRPVRRKFRRSGFKGELVYFENSPDFCKPDNSLLIQGTEGRVCSRDSLDTDNCKSLCCSRPYGTKKLSVTKRCRCHFNWCCYVICDVCEETSVLNVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5F6</accession>
    <name>A0A6P8I5F6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116298755</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031563158.1">
        <property type="nucleotide sequence ID" value="XM_031707298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298755"/>
    <dbReference type="KEGG" id="aten:116298755"/>
    <dbReference type="InParanoid" id="A0A6P8I5F6"/>
    <dbReference type="OrthoDB" id="5978462at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="5">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031563158.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32758" checksum="0654DAB3BC365494" modified="2020-12-02" version="1">MPCFMLECASSLSSSCSMDAQQVRVVLLNIVAWILLFVAFIRPPPQQNLFPLQHRLFENFHGEIFRGRDVFSLISRKAHLFWRNTGETPVSFLKLANDILPTLQNLRLDGQPRVRQRRLKINVVNQVLLVMMWLRKYSXIDTLALWFDIDPTSVIRIIYRTLPVMWRYFQNQITWPNLAEWRNRMGSWPELPNAVGAIDATPHEIYCPLAEPQRPFYSGHRHYHCLNTQLVMDNEGHIRFLQAGFLGSTHDATAYRLMQPIGPGLVLDLPPGVKLLGDRGYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7A7</accession>
    <name>A0A6P8I7A7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC116298788</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116298788</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563201.1">
        <property type="nucleotide sequence ID" value="XM_031707341.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116298788"/>
    <dbReference type="InParanoid" id="A0A6P8I7A7"/>
    <dbReference type="OrthoDB" id="5959569at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF5">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027814511" evidence="12">
        <location>
            <begin position="16"/>
            <end position="3257"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="197"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="317"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="443"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="2411"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="2498"/>
            <end position="2580"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="2971"/>
            <end position="3066"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="3067"/>
            <end position="3168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1296"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2369"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="18">
        <location>
            <position position="2165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031563201.1"/>
        </source>
    </evidence>
    <sequence length="3257" mass="365699" checksum="B8893467333D67B6" modified="2020-12-02" version="1">MWCLLYCCLTHKNLFFLSDINECNKNNGNCQHTCTNKPGSYECGCHRGYVKHKIIDNMEICIDLDECKYQKDPPACRCANIKEAECNATCINEIGSYRCTCNKGYRLIASTICEDIDECISPTTNNCNLKCLNLPGSYSCHCPRGFLLGKDGSTCEDENECKTKKGCQHRCINTFGSFRCRCRRGFRIHPNGRQCIDVDECKVFKPCDMKCINLQGSYRCSCPNGYKLNNDNFTCSDIDECRPGNTSLSDCEQLCINTQGSFKCSCKRGYRLRRNEKACKDVDECLTGTHKCDQKCQNSIGSYVCSCGPGYKLKDKKKCQALPCESIEGPSRGSMKCNGFSTGSICTFQCDLEYDLVGSEESTCLPSGKWNGTRATCKVKQCPKLAAPENAEVFLPCHNTIRSRCLLKCVDGFHSAEGGVATCQXESFSGFGKWNLKNFHCKELKLCSPNPCLNGGKCSLHNNNKFYCDCADTGFEGPRCETGIITTPTYQRLKINQESKVYHLNAQPKSELRVTIXSTQAVLVKPQSELRISKLSRQVAFTLVSRKPGLHIIAYTLDGDDAKVFKAPEENTIFVGPDSVSKDNVYNRLQISKGNLPEGCHELPKLFQCNARLTSTFPWGTPSATSTEGIVHLRTKSLNIPISLFGVSLNELSFTREQLLSKIEETSLQDVPAKTDLSFIRDGKCHSTPMKKDYLFDFIQNDALPRSIFRSLSSVLPPWIELQLDQSNDVFDVTNLMVSVGKPMSDGSGMCEQLPISPSSVFFKPSIAFNTKIGDETKAFKSEERVCLALDVCQSKSFIDLSSQARKRFQQMKIFKDMKRTGWDFKVSSFGMQNNRSDDAVGKNNFDIWMKGEIKVRMTGPRVGVQLNSTGEIFTTSDCPKKLLSRQLTCSISGSANGRITMQTSIKTGDSELIPLKLKSENMVGQFLLGGDKCDQGINLTLTSSENPVKGTMLSQFILPYLKYPMNVTINHDIVGGGGQSGVRIPRNLGTTVILLGFIMQQFQFTAQSIPNVVPDLSSDANKLLDIVNDVNAQATRMRQLVMSSIDKTLVNQEAKSIINTVEILNEKIESILTRTTALSQKLLSHTSNPMVSGIIAQLQGFHTNVELYAKSLKLDTERSPVKQILKGLSIGMMSQVCIGRLCVPDVKAKILANNDVTTTACLRKNTSAGATVKQRTFPYVFISPSKNIELGRLLQVKEGEEMRMDVFKNLMRFKTTMHLFGMTKTVNLNITNQQLYVKVRGNIFNKFESEINVTADTKVDDWESLIFKASGKMGQGSQLPRMLENAVNEYAITMVRKAENRIRKAKTLLESTVNKTKNTDAILISKKNDWDLSIKNKKNLENMLKRKRADFNEYFQKFEDAVQDYDKFTKRLLSKSCNLTDCKRLCSKTCIPDMCWDKAIIQYQKHDCVEVNAKYIKFVPGEVTRKVTYPTTPQIRRDVGKCKSFLTALGEGLIKGGAKLAFSSLLGRRKKRSITNGQDFQNVPNFNELLKKSNPNLPRDFDINGELRKISSKLPKDFDLNKLLASYFIKQHKFDPSEILKRYFPALPADFDFDEEVIKAVPELRNNFDFDQVMKDVIFKAQRLKRKVDLKRELVKRIPELRNIDLDRVLKESLPPLKSLKNITGHIQTSLDDVLSFKVKKTLLERFDVNDIIKTKLRGLHRDVDLNKLLKKRIPQLGKNFNLNRLIINAVKRNPGNLGELNLNKLVRGDMGSIPGLQNFNLQNTLQDMVPGFAKGLNFEKFINNKLRDVVSVDINPLKLEKLNFNNIINKQLPIIKDLGVNKIFKSAFPTLGEMPSVGKILSEAGSLMNMVEDFNVNGIVKGAFKHLPVNLNLNIGDALRRNIPALRGVLNIEGILNKGLKQFINPNIGNILKNVPGLPNLPGLQNLPGMLNLPDLPNLEIRELFKNLKAAFSEDIFANIGDAFQNFGQNLMKNFAGSFGNIVGDSFMSAFQNSGCKHKYVTEAGPTEYRSYQETRAIMVGKQFSEIKWKCTNPRTVNMTSEGFKPRSCCRKDIKCVEFLDPQCVKRNQECFKEKKNIFKQEQSFYNASILFEYPHLIESEKELAHIELRLEEARLREQNAAHDYRIVSARLRQLQALENASMISLSKMKSIPDVDLGLKIGTILNKSYKERPFRMLSLYFHTKTSSLSKSRLPLKGTVTTKDGPDLTFXXIMDFXDVXLSIEXXTKSVIXKLAQSIETSRKRRSVEIDFSNSSQKSDPIKENENCLLARNTSLFFSEMLSALHKLLESKFAQDNEISNEITAIDNLEVTLADDAARSSENDLSKSYVKTISSYKEQRKEQSRMASWNETIVGWRNFVENISKTRDLKDCSNALDCVKEQSERLVELYKSVKNSTKAREMQTLLPRLADGMKELMEEELEMEEVRSRLQNLTMLLNETYDDSLLCGEKPVILTKDSKQVNRLVGESIKLSCLAKSQTKVIYTWRRDNTVIKVSDKSGDLELRLLNETSQGLYRCEAANHKGSIFSGITALVIQKKPTIVEHPTNVQVPLNKQSGVTFSCAVNAKPLATIKWLFEPLSSNLSVELTNENSNLLYVVPDEVEKSGHYYCEASNERGKAVSRKARLDVLNIAATNPKIAVIFNATNKCQVSSSCQGENTLGIPSRLDKTLKTSITSLVTTAMNVSRKSISNMRYIPLSKSMAKVYFFLSESVKLEAIDFRLQEEVMERFSEARLNVVGKLKQLMHAMNRTTFVSQGSKANLTGIAKSLGFLYMAPDCPSGQYLHDNGYMCVQCPPGSYKDGIEETCTKCPIGTYQPKPGQVTCLKCDQDKTTLQRSTIEKSQCIEKELCPPGTFDQVLDDICRKCPIGTYQPRPGQTSCIKCGPLKTTLLEGSSNRSQCIQKDVCPPGTFLDGGCMKCPIGTYQDLPGQTRCVKCSPEKTTWFQGSINETQCVKKECLPGTFEEKDGNCTKCPPKTFQPQAGQKRCIPCIYSLGPLKDVEGRKTCEKPGPGKPRSLMAFSLGSDSLKIVWWKPETSEVSHYDLEYGFIKKTPLQTIRVIPGKNWASGEIYRLRGLLKYTAYRVKVYTVVNNERSKPAIITVRTMDDVPGRSPTITSATAINATAIKVTWQQLPISQRNGIILGYEVYIKIKSDSFFKKQNIDRGDQLSTVLTNLKEDTLYCIKMTAFTRKGAYPHWQRKGCKYARTPIKVSKIFGNVTAHVIGQNVATITWKNKDGDLKSQFVVYYGKQEMKLDQTATCQAQLCTILNLEGGTTYYAQVHAVGQSDVSKVISFSTALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7Q4</accession>
    <name>A0A6P8I7Q4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116296782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116296782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560725.1">
        <property type="nucleotide sequence ID" value="XM_031704865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7Q4"/>
    <dbReference type="GeneID" id="116296782"/>
    <dbReference type="KEGG" id="aten:116296782"/>
    <dbReference type="InParanoid" id="A0A6P8I7Q4"/>
    <dbReference type="OrthoDB" id="5984732at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031560725.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39386" checksum="D0820FE5637A618E" modified="2020-12-02" version="1">MLNMVVDGKLSRDAGFHVGHARPQKCRLSPFIMYSGITYERKYKMAACLTVEEVLEEVWRDSGDDNDVDRLEDDLGEEEDVEKSKLLKWVENFDGGNVFDGEFFRRGAVDLLLPLLRLSSRISECNSSEVDARINVAHVLISHTITTGSILDSEARLWLRQIYRRLSGRVSIRRPYYAEIHRNIPYAIVQAMSLVIQQCPDELKEPVCYSSKNKKGHVISFTTRDAVIWFLSVITSMSKIEVRAFLTKKLKGARRNKHRVKVLVEDGKDFAFVYYHNKGLMSIQFHYGEWNTHDYPQHPCQLTFLPNNEVYRISPSKPFPLTLYPLPHLPTPSLGLPFFDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8X7</accession>
    <name>A0A6P8I8X7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 15 member 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116299938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564523.1">
        <property type="nucleotide sequence ID" value="XM_031708663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8X7"/>
    <dbReference type="GeneID" id="116299938"/>
    <dbReference type="KEGG" id="aten:116299938"/>
    <dbReference type="InParanoid" id="A0A6P8I8X7"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17347">
        <property type="entry name" value="MFS_SLC15A1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031564523.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="83159" checksum="DC0556C0DE5796AD" modified="2020-12-02" version="1">MGSKKRDMDEDLTGSVNYLTNTRNSEEDQLKTGNCCARTKSWFTQFPRATWPILVTEFGERFSYYGIKTVLVLYLTKDLMFNKADGKTIYHAFSMTSYFTGVIGAMIADSFLGKYRTIAYTLFVYSLSEMLLTATSADTIGNRSSIGPLIALFLMAIACGNIKPCLAAFGGDQFRADQEHLLDLFFAMFYASVNVGAVLCMYFIPIVRTDVQCYGRDCYPAVFGINTVLIIVAFLAFIGGKRMYTLKDPAGNVFIKVIKIVGHALGNKISGSGPPNTTHWLDNALDTYEQKEVNDVRMLLRVLVMYIPLPVFWALFHQQGSSWTLQAEQMDGDLGPLGTLRSDQIQALNPILVLILIPLYDAVIYPMFERCQFPLSPLKRMTGGLGLAGVAFVICAFVQIKIQTVGVGPSIPSSGHTSVQFINTIPCDVSINPTSFFRVDLKYGERSQVYEGQFGMNSFRITTMSCNITEDTVTKILEDQTVVSAVIGFNDKNEPTMSQHTMKLPGVDIETAVSRVRILYTSNDKMTEQVDIKLDNVIDDKKSTVLKNMSSSTDKYQDIPTGEYVISELIGRKGNTSTVYKPKSSKRLKLANFGAFTLVISPSKDGKFDVHIFEDAPGTSVSRLWQVPQYIVLTAAEVMFSVTGLGFAYSQAPASMKSVLQSFWLLTVAFGDLIVVILSSAKPVRGVEKEMFLYGGLMGVIMIIFGIMSYFYKYVTLEEVSASEHVLSHEPNGEIPLEEKFSDHEDTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9V1</accession>
    <name>A0A6P8I9V1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD finger protein 21A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116297348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561425.1">
        <property type="nucleotide sequence ID" value="XM_031705565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9V1"/>
    <dbReference type="GeneID" id="116297348"/>
    <dbReference type="KEGG" id="aten:116297348"/>
    <dbReference type="InParanoid" id="A0A6P8I9V1"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15523">
        <property type="entry name" value="PHD_PHF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF28">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031561425.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12357" checksum="318A68D96BA706F7" modified="2020-12-02" version="1">GRPPKYSSSAPCSPKTTSPVPNGLGEPGNKRFKYRRFITEDSPPDEDDDHENACTVCKSNGELLMCDTCNLVYHLKCLDPPLTGIPSGMWICPKCKVRSIDKAVMKLRANTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA68</accession>
    <name>A0A6P8IA68_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acid synthase</fullName>
            <ecNumber evidence="5">1.1.1.100</ecNumber>
            <ecNumber evidence="2">1.3.1.39</ecNumber>
            <ecNumber evidence="8">2.3.1.38</ecNumber>
            <ecNumber evidence="9">2.3.1.39</ecNumber>
            <ecNumber evidence="7">2.3.1.41</ecNumber>
            <ecNumber evidence="4">2.3.1.85</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="73 74" type="primary">LOC116299530</name>
    </gene>
    <organism evidence="72 74">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="73 74" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="73 74">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="36">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="66">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="66">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="59">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="59">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="52">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="52">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="61">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="61">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="62">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="62">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="63">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="63">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="54">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="54">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="64">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="64">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="58">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="58">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="40">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="55">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="55">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="53">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="53">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="65">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="65">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="60">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="60">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="57">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="57">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="56">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="56">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="67">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="67">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="51">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="5"/>
    <dbReference type="EC" id="1.3.1.39" evidence="2"/>
    <dbReference type="EC" id="2.3.1.38" evidence="8"/>
    <dbReference type="EC" id="2.3.1.39" evidence="9"/>
    <dbReference type="EC" id="2.3.1.41" evidence="7"/>
    <dbReference type="EC" id="2.3.1.85" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031564060.1">
        <property type="nucleotide sequence ID" value="XM_031708200.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564061.1">
        <property type="nucleotide sequence ID" value="XM_031708201.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A6P8IA68"/>
    <dbReference type="GeneID" id="116299530"/>
    <dbReference type="KEGG" id="aten:116299530"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000013">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
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    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
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    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
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    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
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    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
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    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
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    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
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    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
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    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
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    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
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    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
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    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
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    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
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    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
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    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
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    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
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    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
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    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
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    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
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    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
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    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
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    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
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    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
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    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
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    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
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    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
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    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
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    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
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        <property type="entry name" value="GroES-like"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="CARRIER"/>
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        <property type="entry name" value="KS3_1"/>
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        <property type="entry name" value="KS3_2"/>
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        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
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    <keyword evidence="24" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="25" id="KW-0456">Lyase</keyword>
    <keyword evidence="26" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-0521">NADP</keyword>
    <keyword evidence="21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0663">Pyridoxal phosphate</keyword>
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    <keyword evidence="15" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
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            <begin position="6"/>
            <end position="413"/>
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        <location>
            <begin position="852"/>
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        <location>
            <begin position="2013"/>
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            <begin position="852"/>
            <end position="974"/>
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    </feature>
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        <location>
            <begin position="984"/>
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    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="68">
        <location>
            <position position="885"/>
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    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="68">
        <location>
            <position position="1035"/>
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        </source>
    </evidence>
    <sequence length="2392" mass="261033" checksum="8194A90D1166C47C" modified="2020-12-02" version="1">MVSNNPEDIVISGLACRLPESDNAEEFWSHLMNKEDMVTEDGRRWKPGLHGLPRRHGKLKDLKHFDATFFGVHAKQAHKMDPQLRILLELTYESLVDAGVDPQTVRNSRTGVFIGTSASEAAEAFSSNTEEIVGYGMTGCCRAMFANRVSFAFDFKGPSFAIDTACSSSLLALDCAAQAIKSGACDAAIVGGVSLTLKPNTSLDFLKLNMLSPDGACKSFDESGNGYCRSEGAVAIYLVKRPVAKRIYAHVVNSKNNSDGYKNQGVTYPSGAIQKELLQQVYSEAKINPADVAYVEAHGTGTKAGDPEEANAITDVFCKGRPADSPLLIGSVKSNMGHPEPASGLAGVTKVLLAMQHGVLPPNLHYKKPNPDIPALIDGRLKVVTEPTEWEGGLVGINSFGFGGSNVHVILRSPNIPQSKPLQDKHQVCVPISGRNEEAVNKLIELANKNQDNEGLLSLLGEISATSTNSFLYRGYTVVGCEGKVQEVAKVKNGGRPVWFVCSGMGTQWKGMGQKMMKIPLFKQSVCSSSKYLKEYGFDLEKMIEDTNEDMYENTINSFVGLAAIQIALIDCLKALGLEPDGIIGHSVGELGCAYADGSFTAEEVLKAAYWRGRCVSEANLPPGAMAAVGLTWEEVKHRCPPGVVPACHNAEDTVTISGEANIMAKFVQELKDEGIFAKEVNTSGVAFHSNYMASIAPILKACLEKFIVPKKRSSRWLSTSIPEEKWSSELSQYSSAEYHVNNLVSPVLFQEALKKIPDNAIVIEIAPHCLLQAILKRSLSNDALSIPLMKRNHKDNVEFFLSNLGKIYMQGININPTSLTCERHLPVPLSTASIAPHVGWDHSQEWDVPSSEQFTSSSGGGGTNSCQFVIDLSSSSKDNYLEGHCIDGRILFPATGYLVLAWRALAKSVGLLPEHMPVTFEDVHIHRATILPKTGTVTLTVHLMPASNKFDVSEGDNLSVTGKIHIPDLPVLSKNFKEAPHLVEEVHLTSECIYKELRLRGYDYGPTFQGIKGANSTGTKGELLWNGHWISFLDTMLQVSVLRLPGRGLRLPTRIRSLRIDPSIHLDMIKSGSCEVKVDPKMDMVVAGGVEMTGLHASVAPKRQDGQTAVLEEFTFVPYIDDTSATTTPDKDIEFHDVLGHGPMLKVMLDVVIENTNTTNLSICELSAVESQVYSHVVPLVNLHPLMHLNYTATDKTQDLLSKIEESATEKGVEMCVWNTVNKPPGSMGKVDLVIASNFSQNAESMSQVIGNIKSMLCPQGFLLVHESSPEARNKLQSLMEVAGFGLASIKQTLGNSSLILYRLLRETIDKEPVVIDIDDSFAWVPDLHSKFNTGDGSTIWLRARGPSHSGIVGMTNCLRQEPCGERIRCLFDGSSSGEDLMKRFEELRKLDLVMNVYNHGKLGCYRHLPMGGEGTTSEETEHAYVNVLTRGDLSSLRWIASHLKYAPGKEGDRELCSVNYASLNFRDIMLATGKLPPDALPGDLAQQDCILGMEFSGRNQSGKRIMGLLPAQALATTVLADQRFTWEVPDTWSLLDAATVPVVYSTAYYALIVRGNLRPGQSVLIHSGSGGVGQAAISICLSMGCEVYTTVGSKEKREYLLATFPNLKEENIGNSRDLSFESMVMHGTNGRGVDLVLNSLAEEKLQASLRCLARHGRFLEIGKYDLSNNTPLGMALFLKNVSFHGILLDAIFEEDNPEWKEVSDLVTAGIASGAVRPLKTSLFDRDEIEEAFRFMAQGKHIGKVVIQVKPEHESSSVVKLIAHARSMCDPKKSYVITGGLGGFGLELAHWLVERGARNLVLTSRRGIRTGYQARRVNGWKEKGVRVQISTNDVGTKEGASAIIEEAQALGPLGGVFHLAVVLRDGLFENQTPATFQEVCRPKYNGTIFLDNLTRQEGIAKDLHWFVVFSSVSSGRGNAGQANYGFANSGMERVCEKRAHDGLPGLAIQWGAIGDVGLIQETMGGTNETVIGGTLPQRMSNCLSVLDRFLSQAHPVMSSFVLAAKQTSKGSKSSGGDLVSAIARIMGVNDVETINPDTTLADLGLDSLMGVEVRQTLERDYDIQLAMKEVRLLTVNSLRDLAKEGTSKTDNEPQQEVKQGNEKINKVIGTQVIPHFTKQTLLKLNDINNGHKPLFVVHNINGSVEPLKTLAAALTCPVFGLQYSMDAPKNSIQDLAAFYINKIREVVPRGPYRLSGYSFGACVALEMSIQLEKTKEVESLVLMDGSQEYVAAHTMWHRKRLTVEEDSWKPEAVAEALCIMAGHYAKVDKIKLMKAIQSLATVQEQLVITVDAIAKVNSSINKQDLLVYLTFFLDLLRMGEQYKSTAKYHGNVSLIRAKTTDEMGKSLGEDFGVGKICEGNVSITWVEGDHVSFLQSNSAVEVANMIMAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAL8</accession>
    <name>A0A6P8IAL8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116300467</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031565203.1">
        <property type="nucleotide sequence ID" value="XM_031709343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAL8"/>
    <dbReference type="FunCoup" id="A0A6P8IAL8">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="GeneID" id="116300467"/>
    <dbReference type="KEGG" id="aten:116300467"/>
    <dbReference type="InParanoid" id="A0A6P8IAL8"/>
    <dbReference type="OrthoDB" id="1418422at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004509">
        <property type="term" value="F:steroid 21-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11027">
        <property type="entry name" value="CYP17A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="10 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 22" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031565203.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="55827" checksum="CC6B55867ADDBDA4" modified="2020-12-02" version="1">MIIELALFAVTVFFIYHFFFEFRGNNLPPGPAPWPIIGNANLLSQEMHLSLTKVGEQYGKIYRIYLGHKLMIVLSGDAIKEALVRQPKDFAGRVEPPFIVKRGPGLPLMDYGAKWKLYRKLGHSAIKIYGEGRLQEVISKEVDELCKRLEAEVGKPLDIAIQFNMAVTNVICTKLLGQRYEIDDPEFLKIYNINDQITRVKFIGASFQKLFPFLKFFLPQDEQTKLLEKMANERFEFLSQKFVEHKKKFDGETIRDYIDALLYTKQQAETEDHANQKYLDDDTIVTAGITSLFTAGSETTSTTLGWAIAYLLHNPDIQERLYKEIHDVIGSDEFPNLNQKKMLPTLEAFTAETQRKANLVPLAIPHKTTDDTVLEGYNIPKDTTVMANLWSLHHDPTIWQDPFKFNIDRFLDEEGNFKSPVGGTFLPFGAGPRVCLGEVLARSELFLFLCRLLQQFKFETPQGCELPSLEGHAAAVLHPKPYLVCVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICC6</accession>
    <name>A0A6P8ICC6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM50A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565191.1">
        <property type="nucleotide sequence ID" value="XM_031709331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICC6"/>
    <dbReference type="FunCoup" id="A0A6P8ICC6">
        <property type="interactions" value="1462"/>
    </dbReference>
    <dbReference type="GeneID" id="116300454"/>
    <dbReference type="KEGG" id="aten:116300454"/>
    <dbReference type="InParanoid" id="A0A6P8ICC6"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="3">
        <location>
            <begin position="179"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565191.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38968" checksum="9F044977E9AF7654" modified="2020-12-02" version="1">MAEYKGASREGQRAQALLKKREKMKEDMEAMKKKISEKNKVGDITSKFSSQYDVVEQRLKESTIGLMTLDEMKARRDTLVKEHEKHLAAKLKSDEQENKKSKREKKREMQKQAAALSFGLDEEEEEEIVDIPIKKKKLGKNPDVDTSFLPDREREEMERIERERLGQEWIEKQEKIKNEDIEITYSYWDGSGHRRTTKMKKGNSISQFLQKCIEELRKDFTEFRAVTTENLMYIKEDLIIPHHYTFYDFIINKARGKSGPLFSFDVHEDVRMINDATVEKDESHAGKVVLRTWYERNKHIFPASRWEPYDPEKKWDKYTVSDIDTPKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICP8</accession>
    <name>A0A6P8ICP8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116298457 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562800.1">
        <property type="nucleotide sequence ID" value="XM_031706940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICP8"/>
    <dbReference type="GeneID" id="116298457"/>
    <dbReference type="KEGG" id="aten:116298457"/>
    <dbReference type="InParanoid" id="A0A6P8ICP8"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000025">
        <property type="entry name" value="Lysine-specific demethylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF27">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028249575" evidence="2">
        <location>
            <begin position="18"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="128"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562800.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59850" checksum="DDFE5E1AC146817C" modified="2020-12-02" version="1">MPAYLLLLSTLLSQGITIHSTEESVFPRGHLQPLGSHRDPDNSLIDELHDVPSAKDFWERYVKPSRAVVLRGAAKNSPAFTKWTDEYLAKHYGDLVVRLERKKEKSGAVPVGVKGIGLDTIGNFIKHYHQTNSYIVSELPTPMWHDFQVQPCLLCGSFRKRLVEVDLWMSGGGSSSILHKDAFNAINCLYNGTKEWKMIEYKYEDKIYKAWEPDREIGGFSRIDPLKVDLIKYPKVAEVPWSFVTINAGDCLFLPKSYYHQVTSYGTMNVALAILFSRFEGEENIDLSDCHGNKSYTPLSELELDWMFPGHGNLSMGNPDLEDVRTILMKSVEEGNPREFVFKTFKQMFPEKSDEWVGNKSEEIAAAVGLDKKKIITTEDIQNLNRDDLRKIALIVQPTDLSNTELHEHTYVNPTAVWEIVKRLLQEDGKLNKKKFIHFYKKEAYGTEKFANEILSKLSKDSDNQWINKEDVSSKLREALSPYFDNQREEYIPPGEMEPEENDAYGDEKDDELPLQPTHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDI7</accession>
    <name>A0A6P8IDI7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger MYM-type protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116299036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031563525.1">
        <property type="nucleotide sequence ID" value="XM_031707665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDI7"/>
    <dbReference type="GeneID" id="116299036"/>
    <dbReference type="KEGG" id="aten:116299036"/>
    <dbReference type="InParanoid" id="A0A6P8IDI7"/>
    <dbReference type="OrthoDB" id="5984651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057926">
        <property type="entry name" value="QRICH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25561">
        <property type="entry name" value="QRICH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="157"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031563525.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="52558" checksum="9E9EA5118A96FA98" modified="2020-12-02" version="1">MSDDEHSDSEFYYPLDYKNNENESEKTREKQSFSVDDVQSFIQTQRPENTIKKTQYDLNVWRRYLSEWGETTEVENIPPQKLNLLICRFFIEIQKKDGEAYEPSTLTSFHRSLQRYLNDKQSTVNIFKDQEFAMSRDALKSKKKQLAEVKAKGNLPQAARGVTDEEEDLLFASGEFGEQNPESLQRTVWWLLSLHFGFRARDESRKLKWGDVSLNVDSVTGKEVLTWGTERGSKTRQGEGNRAFKPNAYASDNERCPVKYYKAFRSHRPQEMLHPDSPFYLAIKHKRMQNSNVWYCKTPLGKNEIGNLLSKAAKRVGLKGNVSNHSVRKTFISRLMDAGVPPNYVAQLSGHKNLKSLDSYSTASLTHQREMSLTLSRSKQSSRSIMAANTTEVSCSEDINAKPSTSTSSSSEGGPFGYGIFPGSSIGRVEGCSFTVNIVHQHVQAPKPAKRRGILESDDSESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEJ1</accession>
    <name>A0A6P8IEJ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polypyrimidine tract-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116299721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564300.1">
        <property type="nucleotide sequence ID" value="XM_031708440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEJ1"/>
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        <property type="interactions" value="3445"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12693">
        <property type="entry name" value="RRM2_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12423">
        <property type="entry name" value="RRM3_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12425">
        <property type="entry name" value="RRM4_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hephaestus, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="179"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="330"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="446"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564300.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="56363" checksum="A4F1E57084558122" modified="2020-12-02" version="1">MTTVAALAGLASGTKRSADDIISSMAGISNDQKKARIDNTNPPSKVLHLRNVPSDASDAEIIALGIPFGRVTNVLMLKGKNQAFLEMESESKAIALANYYSYVTPTVRNRPIYVQYSKHKELTTNESQHAPGTSHILAAASSSEVVAAAGSALSGLSANQLSSSTSTSTAEAGGAGCVLRIVISNIIYPVTLDILHQIFSKYGTVLRIVTFTKNDQFQALAEFSQASEALSAKYCLDGQNIYTGCNTLRIDFSKLTNLNVKYNTEKSRDYTRPDMPPGDVDGAAAFSLPGLGNASSVLGNPAALLGLPMGLPLANISMAGVNQRYQGGSPLVLVSNLNEEMITCDALFTLFGCYGDVQRVKILFNKKDTALVQFSNAQQAQTSIAHLNGVRVYGKEIKVTVSKHSSVSLPKEGEDNNLTKDYSNSPLHRFKKPGSKNFQNIFPPSRTLHLSNIPEGVTEEELTAHFSEAGEVTDFRFLPKDHKMAHLTMASPEEAIDALIKMHNYKISESHHLRVSFARSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF01</accession>
    <name>A0A6P8IF01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neuferricin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116300332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565045.1">
        <property type="nucleotide sequence ID" value="XM_031709185.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IF01">
        <property type="interactions" value="1429"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116300332"/>
    <dbReference type="InParanoid" id="A0A6P8IF01"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="95"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031565045.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="34893" checksum="41E28AC4F5123172" modified="2020-12-02" version="1">MAKITELEPSDGEETSKRSKESKGKLMSSKPVPRDQKPPSGTSGSLKNTTGTLYMNYIALPIVIVIISIAVLYFSNQKAIDEVKTPSLSKKGVVMSATELAKHDGSDSNIPVYIAILGRVYDVEKGRRHYGKGSGYNVFAGRDSTPSFVTGMFNREKATDDVSGLSPEEMLGIKDWMDFYRKDYXYIGKVIGRYYDENGKPTDALKQAKALIKEGKRLKEIQKGEDKKFPPCNSKWSQTEGAEVWCSKESGGISRNWVGVPRQYFKPGSKDPKCVCVRTSGVSSDTREGDEGDLNHPNLKLYPGCNKMDVMCRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II85</accession>
    <name>A0A6P8II85_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neutral cholesterol ester hydrolase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116301645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566591.1">
        <property type="nucleotide sequence ID" value="XM_031710731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8II85"/>
    <dbReference type="FunCoup" id="A0A6P8II85">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="GeneID" id="116301645"/>
    <dbReference type="KEGG" id="aten:116301645"/>
    <dbReference type="InParanoid" id="A0A6P8II85"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="134"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="361"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031566591.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52888" checksum="B6B95A66E23718C3" modified="2020-12-02" version="1">MRGTLVILAILAVFSAIIIHQLHKRLFGIPVPDGLNPNSTFSFQVVGFLFNFAKDLSRLGTRLGIVNNYHISVRNLFEKFSYLVLNNSFADQLEINDTEIFGSKVRIYKPVNKTKDKKKNDERKDENEKLMPALIYYHGGGWTIGSLAAYDAFCRRVAVTAQVIVVSADYKQAPEYLYPTAFNQCYNVAVGLLNTGAQYGVDVKRVMVGGDSAGGNLAAAVTHTVAYVGEKHCRKQYIAGQILIYPSLQMLNFNLPSYIANEDGVILSRHDVAEFVSVYLTGNTDIVDAMLAGNHSKHLENTTYMSYFKSEESDEGPIREEENEAGIDDEDETSIENQNIGKPLIEMTDLVAEALINIKGSPLVARNFRGVPQTLLLSAECDPLRDEAFLYAKRLKKAGIDVVHKHYPSFHGFVTVTSEPWPYGTVEAREAIQEMVRFIDRMKKMKDKEQEEEEQEEEEQESQKQKSDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJH4</accession>
    <name>A0A6P8IJH4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BTB/POZ domain-containing protein 6-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116302007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567046.1">
        <property type="nucleotide sequence ID" value="XM_031711186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJH4"/>
    <dbReference type="GeneID" id="116302007"/>
    <dbReference type="KEGG" id="aten:116302007"/>
    <dbReference type="InParanoid" id="A0A6P8IJH4"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000008">
        <property type="entry name" value="BTB/POZ domain-containing protein POB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031567046.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="59129" checksum="52872F68CE93CBF8" modified="2020-12-02" version="1">NGNYNLRTELSSLKERNLYAFYNSLFCDVEFTVLDSNGEQVTLKAHKYVLAIGSPVFEAMFYGELAEIGPTIDLPDCTKEGLQEMLHYVYSDEVNLTGSNVMDVLYAAQKYMMPFLENKCSEYIQKELRPEDVFIVLPQAQQMKNEKAELCCWNVIDFEAERAVTSEPFLDISRELLIQVLARETLHVEEIELFKAVDKWASNQIKDEKLKHDGATKREVLGEEVIRLVRFPIMSHHEFAQFVIDSNILVLAETNEFIKVLGSATTSEAVFTAKKRDGQWNEKWSPNRFRSIKGNGNEEVMNKGVQRHCIQIQVNKPVYLAGVTLFGAQFQVPKIKLTIAKGMKGHVYNAGTNNFGVIPSCDTRKTLPMGFAFGSSTPPSMRIQENTRALIFGQGSTISGLPSPPSPVFKHTYAELTFDGTAVLIDGSYHGFKLLFEGLPNHSPVPLEPNEWYFIQAELSGQCSSFAGSEGQDAVKCDDITIKFKNADQNSTTVQTGQFPSLLLKRKVQLLSQEPRSVIDQFQVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL56</accession>
    <name>A0A6P8IL56_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116302369</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP8 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567507.1">
        <property type="nucleotide sequence ID" value="XM_031711647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IL56"/>
    <dbReference type="FunCoup" id="A0A6P8IL56">
        <property type="interactions" value="2603"/>
    </dbReference>
    <dbReference type="GeneID" id="116302369"/>
    <dbReference type="KEGG" id="aten:116302369"/>
    <dbReference type="InParanoid" id="A0A6P8IL56"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000100">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000121">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000035">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031567507.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="63950" checksum="FB14711DB62199A3" modified="2020-12-02" version="1">MPRGVKVERPVSTEPVEHAVQASTLIVLHPGSTTMWLGRATDHLPKSFPHVIAWRRPPQNTVPLPNDGILEREGIYHADSETQRDLALSLVEQAIWSRNSSLGMSRKQQISSSQVAAYNSGVEPEVLDEEDCSVEWTDLSSQPTYVAGEQALYIDPREPYNLRWPMKFGCLNLHGGPGGSLTAICEDLERIWANAIETMLKIPLTDLPFYRAVLVIPDSFNKNHTKEMMDILINRLKFSSAIIQQESVCSTFGCGLSSACVVDVGDEKASVCCVEDGLVIPNSRHWLHYGGRDITRCFYWLLKKVNFPYKECDLKSNLNTFMLTELKETFCHLSQDIVGGRVHEFQVHHPNQAPLSYNLKIGNEAIQAPMAMFFPQLFGIVGKRLVFTSDPPYDDPEDLLDDRYLLESQRGDQSSKKGGAGTDTANEADQAEVSGTPVIPGNRKRPMVASAEKTLAMDQAIIQSIECCPSEDTKRKMYSNILLIGGGFSFNGAAQVLQTRVQAKLPSHLRKLVDQVEVIARPKEMDPRIVAWKGGAILSILDSAQELWVTEQEWNIIGVRALREKSLFVWSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILE9</accession>
    <name>A0A6P8ILE9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116302454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567602.1">
        <property type="nucleotide sequence ID" value="XM_031711742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILE9"/>
    <dbReference type="GeneID" id="116302454"/>
    <dbReference type="KEGG" id="aten:116302454"/>
    <dbReference type="InParanoid" id="A0A6P8ILE9"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567602.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="21652" checksum="09E2599C1C276A7F" modified="2020-12-02" version="1">MYFPAAVSPGGSYGQYPAAPQSTAQGCCSSYGYQSQYPVQAPAPPQQQQSCCDSSNPSPPPCCINLKPGESKEVKLNAAGKNYLLTVNLDGHGSGSADGSNKSKDASVTKTPPSSIPTDSGPTTQPGTNGGSSTGSTMGPTTSPTTGLPVNLKTGSGSTAPTAAPDSIGSSSDNGIDNISEEIDKLFQSRGVKARKNFKMELIPMRSLKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILT8</accession>
    <name>A0A6P8ILT8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutamate formimidoyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.5" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031567585.1">
        <property type="nucleotide sequence ID" value="XM_031711725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILT8"/>
    <dbReference type="GeneID" id="116302436"/>
    <dbReference type="KEGG" id="aten:116302436"/>
    <dbReference type="InParanoid" id="A0A6P8ILT8"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="entry name" value="Formiminotransferase, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="entry name" value="Formiminotransferase, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051623">
        <property type="entry name" value="FTCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234:SF1">
        <property type="entry name" value="FORMIMINOTRANSFERASE N-TERMINAL SUBDOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="4">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Formiminotransferase C-terminal subdomain" evidence="3">
        <location>
            <begin position="214"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567585.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="36297" checksum="82D3F5B83206D1B8" modified="2020-12-02" version="1">MRKTSQSLRLIACLLNISEAHNERIVESVALSATNLHIPKQDQFQGLGGKNSNGGVKCPATVLNIFSDLDYNRSVITIAAPIENIEESVYRACETAYDQIDLGNHCGGHPRLGSVDLVPIHPINSEVDLKECGQVAQRIGHRIVENIKGTSVFFFGHADVPQNRGLVNRRKGVNWYKGKGGMSFHNIGWDLGQRPSPRYGCTGVGAIPYITNCNVTINTKDLALGQEIAKSLRASTPGGLQGVQAMAFEHNEMVEIACNVEAFEDPSSDGQIQYTKAEEIENKIKGLANTRGVDTFGSKLVGFTPNEAYFRAEKALLEGNATVWKSLEQGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN42</accession>
    <name>A0A6P8IN42_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568466.1">
        <property type="nucleotide sequence ID" value="XM_031712606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IN42"/>
    <dbReference type="FunCoup" id="A0A6P8IN42">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="GeneID" id="116303130"/>
    <dbReference type="KEGG" id="aten:116303130"/>
    <dbReference type="InParanoid" id="A0A6P8IN42"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="28"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568466.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="70738" checksum="52451D276F71D6BF" modified="2020-12-02" version="1">MLCCKKKPLDKKTEPLVEYPDGGWGWFVCLATFTTQFIVLGTMNNFGVMYVELLREFNVGKAEAAWVGSITYGMMFLLGPLGTTLCKKIGCRLTTIIGCSTASGACLLASIAPNIYVMDLTYGLMFGVGASLCYFPTVVILGTYFNKKLSLANGLTSSGSGVGSLAMGPVLQGLLSRFGMRNTMRISAAMLACIIVIALVYRPINTPFLNGSKYDKEKEANQKKKGCARFVDFSLFKNKAYLVWCGSLSFWMLGYFVPFVHLIRLATLQGIDMFKATLLIGMMSVGSTVGRLFFGKIADHPKINRLYLYQFSFLMIGISNTICPLMTNYGGLAFYATFFGFFEGCYVLLAPVLTGDIVGRNNMATGVGVLFAIKSVPLTIGPPLAGFIYDTSNSYEVAFYIAGAVPILAACIMFAIPFLMPKDQEDETDHKHYGKFEVIMDEKEEEDRSSGYDSQPRIPQLFIEPATPTLPPESLRSESLPQIPPHILHNPKRLSGDHTELRPISSIPKHLRPKSVQSFASLTGSHVSINSILSRSGPSTYNMNALPPIQENSDHYNVRRSRVLELQRELSPSVFSLVRRRLELGAPTNKKTMIPKQISASKYGGSIGCISITSDAVPLAYSEEVAKEEDREREIMIGKVSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INZ5</accession>
    <name>A0A6P8INZ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568557.1">
        <property type="nucleotide sequence ID" value="XM_031712697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303202"/>
    <dbReference type="KEGG" id="aten:116303202"/>
    <dbReference type="InParanoid" id="A0A6P8INZ5"/>
    <dbReference type="OrthoDB" id="5947362at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028312396" evidence="1">
        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568557.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22776" checksum="A8D37DC62FCF52BF" modified="2020-12-02" version="1">MLIYAVFLVLAIVTSAEVADVSEVADVSEVIDDQGQQNCWETGWVKISHHTVCFEPKGNRYGSFNNYIRGGMVTAIKLEYVSGKVRCIGGVEYDSRWGCYNYAPFKNYPLDVIVTDDNDNILFPKKEYIKHTAGLWYWSPFVNPLDSDELIFTDYRTPFYFPLDKEMRIWYGEDLKNWXEGDNAGRVCVNVYARFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRM5</accession>
    <name>A0A6P8IRM5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arf-GAP domain and FG repeat-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116303489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568903.1">
        <property type="nucleotide sequence ID" value="XM_031713043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRM5"/>
    <dbReference type="GeneID" id="116303489"/>
    <dbReference type="KEGG" id="aten:116303489"/>
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    <dbReference type="OrthoDB" id="6036at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000005">
        <property type="entry name" value="Arf-GAP domain and FG repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052248">
        <property type="entry name" value="Arf-GAP_FG-repeat_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134:SF3">
        <property type="entry name" value="ARFGAP WITH FG REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134">
        <property type="entry name" value="DRONGO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="367"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031568903.1"/>
        </source>
    </evidence>
    <sequence length="717" mass="72612" checksum="96C0DE4A5E5D9B98" modified="2020-12-02" version="1">MASAKKKQDEKNLKILRELASQPHNKKCFDCGQRGPTYVNMTIGSFVCTACSGILRGLNPPQRVKSISMTSFTPQEIEFLQGAGNEMCKKTWLGLWNSANSPEPESRDEQKVKDFMIQKYERRRWYIPPQQVSASSTSSSNSVPEAKPLKQLLGKDTPTVQSSSPVQNTTRERPRTVSQSSLPAPVPAPAPVSSGVSESQPAQKPATSFDLLSDLGGDPFAQPSQQSQGFGAFGSQPQQQAQQSVGIPGFDAFNQPPSQPASQAPFDPFGSSQPAQPMQSGFANFGQPPQQPQTQPLQQQSNSFDAFGAFASPVSSGPASQSTGAGFGPMVSATSSASMPSSNPPQHAGDKYAALSALDSLFGPTPAVSSSASHTSTSSSGTSVFGSSSGTSVFSSGSGASLGMSSGPNPFVSGGHQPSQPASHNANPFQGLGNVGGSGGGFAQMNGPGRSLSPPSSTSTGITSSAGFGSFSSAQPSSTSFGQPAAQQPQAMSGWGGMGGQHAMGVPASSASQNLSFGGAGATVMAANQFNKMPNQPNPMGGQAGGFGGGHSMQGGFGITPMGGARMGTPTSSAGFGQWGQSSSFGMQGGGHSSQMDGYGGGQSGGFGGQHSGYGGQQQSGFGAQQGGFGAHQGQFGGQQQAGFHGQGAAGSGGGYGGQTGGFGGGGGMMGGQFGQPQPQQQQQQFGGWGQPSSQPNPFMGGGGQPQMQQQSTNPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS69</accession>
    <name>A0A6P8IS69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CUB and peptidase domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116304414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570016.1">
        <property type="nucleotide sequence ID" value="XM_031714156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS69"/>
    <dbReference type="GeneID" id="116304414"/>
    <dbReference type="KEGG" id="aten:116304414"/>
    <dbReference type="InParanoid" id="A0A6P8IS69"/>
    <dbReference type="OrthoDB" id="5946541at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028416305" evidence="3">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="4">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="165"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570016.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44831" checksum="4A3DFBEBC242D3ED" modified="2020-12-02" version="1">MRSFWLTLLLYAVLNVGQTEETEYVIKVRTGTSFGAGTDANVFIKIIGTDGITAEHKLAGSGDPFEKGSLDTFTINDNTQIGDLTAVKIRRDENGWFAKWQLEKIAVQNKTSGKWSMFPYGSWTSPNTWITIPVRCDADYRKNPKTGSCQGPLCGTKMSAVSSRILGGPRVLPASWPWLGIVEFDNGGRICSGALISPRWVMTTAWCVYKKRPTQMRVRFGANNANVRLSTEQTINVESSFLHPDYHKYVLMSHDLALLKLSRPVAISNNVRPACLPSDQITLPVNDPTKRCWFQIWDRDTYDLKEVSIPLKTLSTCVKDGRPLPKVHESMICGKLLRNETGPCTSDAGAPLTCEAQGKWYLEGLSSTGTDCYIDGPKSRLFSNIRYMKQWAESIINSNPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITT3</accession>
    <name>A0A6P8ITT3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570332.1">
        <property type="nucleotide sequence ID" value="XM_031714472.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116304698"/>
    <dbReference type="InParanoid" id="A0A6P8ITT3"/>
    <dbReference type="OrthoDB" id="5959214at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028379630" evidence="1">
        <location>
            <begin position="23"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570332.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42299" checksum="376F965DE20E1179" modified="2020-12-02" version="1">MKYVVWFNAVMLWLAVISTKRATALLAKKCNKDLDCNVISQTCHPLLKICVAKQGSLTVPGRRSSKPICKKCXANEYCHSIFKXCLKTLTPPSTRNNKKPTASDCKHDXDCTNNKYCHXTFHKCLDIPVIPTMSTARRSTQSCRNDSTCGXNRYCHDFFKICLERLTVFQNVTTPXVKYNCTRDIDCLPGQYCRNMTNTCLQVKNLSGSGLPSPPPKHGRCSKDSDCNINEFCHQHVSVAXTKKRRRKCSSGRRCSPTRRQQTGLGVCTXSMVALHPPSGNCSXDGDCGPGMCCLTKLGICKHISTRGDPCVTQPADFTCPCSTNLFCKANSKKRKLKGRRLERRLNLSTHIHRELKKRGLLIHKKYVYGKCHKIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUH2</accession>
    <name>A0A6P8IUH2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21 25">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="7 25">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC116305218</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="28">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 25">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 25">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="7 25"/>
    <dbReference type="RefSeq" id="XP_031570936.1">
        <property type="nucleotide sequence ID" value="XM_031715076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUH2"/>
    <dbReference type="FunCoup" id="A0A6P8IUH2">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="GeneID" id="116305218"/>
    <dbReference type="KEGG" id="aten:116305218"/>
    <dbReference type="InParanoid" id="A0A6P8IUH2"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000014">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 25" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17 24 25" id="KW-0129">CBS domain</keyword>
    <keyword evidence="18 25" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="19 25" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 25" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CBS" evidence="26">
        <location>
            <begin position="396"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_031570936.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="58811" checksum="C7248CFEA731AD9C" modified="2020-12-02" version="1">MSTEVKICPQSLNFGGKERKWIRPDVVSKCTWHLGAKLSDSPHYHAKSREPSSKIMPNILQKIGDTPLVRINNIGKSCGLKCELLAKCEYFNAGGSVKDRIGLRMIEDAEREGTLKPGDTLIEPTSGNTGIGLALASAVKGYRCIIVMPEKMSKEKVDVLRALGAEIVRTPTEAKFDSPESHIGVAQRLNQEIPNSHILDQYRNPGNPLAHYDSTAEEIAFQCDGKIDMVVLGAGTGGTITGVARNLKTKCPNIKVVGVDPFGSILAEPEKLNDTDVTTYHVEGIGYDFVPTVLDRSVVDEWFKVGDKEAFSMARRLIRDEGLLCGGSSGSAMVAALQAAKSLGEGQRCVVILPDSIRNYMTKFLSDDWMEEHDFIELSIHDENSKLWWWSKKVSVIKLQSPLTVLPSISCQKCIEIMSREGYDQIPVVDDTGAVLGMITLGNIMSQILAGRLKPSDDVSICIYKNFKKVTLDTDLRKLSRILDIDHYALVVHSQRVYNDTDVMKQKEMIFGIVTRVDLLNYITHAEAKSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUQ9</accession>
    <name>A0A6P8IUQ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Microphthalmia-associated transcription factor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116304335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569915.1">
        <property type="nucleotide sequence ID" value="XM_031714055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUQ9"/>
    <dbReference type="FunCoup" id="A0A6P8IUQ9">
        <property type="interactions" value="3024"/>
    </dbReference>
    <dbReference type="GeneID" id="116304335"/>
    <dbReference type="KEGG" id="aten:116304335"/>
    <dbReference type="InParanoid" id="A0A6P8IUQ9"/>
    <dbReference type="OrthoDB" id="6242697at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031569915.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51263" checksum="469280F7C0E5D101" modified="2020-12-02" version="1">MCESGIDLGFDLLEEGFQVDNFSSSYYELKSHPLESVQEGSVLGLLLSTGSVAQTTYTPTPTMASPMTRTVFKQQLQKQHLEQLEQQEKKLNQAVAQTSQESQSISIPSSMGVSSAPSSSLPHEVPTSVLQVKTKLENPTRYYVNQQRERQVKQYLETHGTLSLPNHLLENTTTNNISNSQPTLNAINQQAIASLGAKRMKPPPSPMSVTSPDGMGNSEVHVDSLLDDIISLESNQGDDVLAWQDPSQIPTASSMYDLYGGLGLTPMVNNTGAPSSCPPAILQNEIEVIDPHAYARDRQKKDNHNMIERRRRFNINDRIKELGTMLPKQDSDMRQNKGTILKSSVDYIRNLKRDLDKMKRVDQEKRQLEMINRKLLLRVQELEMHARAHGIPTTPLTADTSTALLSTVLAVKSEPESQLSCDFSIKQEPLDPNESAEAMEAYSLASSRNPSPGSVDMDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUW8</accession>
    <name>A0A6P8IUW8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ectopic P granules protein 5 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031570732.1">
        <property type="nucleotide sequence ID" value="XM_031714872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUW8"/>
    <dbReference type="GeneID" id="116305044"/>
    <dbReference type="KEGG" id="aten:116305044"/>
    <dbReference type="InParanoid" id="A0A6P8IUW8"/>
    <dbReference type="OrthoDB" id="75419at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570732.1"/>
        </source>
    </evidence>
    <sequence length="979" mass="112818" checksum="1EFD5BDC43CCEC4E" modified="2020-12-02" version="1">MEAVKPRKKHRKKNKTPATESVKTEEDSINVQGTALESEAREEQVDEEQDVAASNAAEKQEEDNKNVDVTEVKESGPDSADANERTVIDKEISKEQCIESKDIEITSNTEGNELTTQTKDITSEFQSSTTDINNLNEELPSNETKNTELGNEWEVLPATVRQDGNEEIESNEIAVPKTEDKAESKNVEDICKEEFVAAEGPTPKERIRVENKTVDAVKNLEKEKEQEKREQERIRETKSIYPKLESASSKEKFKESIKERILLEPFTEDELKIFYFNPLLEQLHGFTDRFLVIAKQDKHEFYELVNTYYRSRNAVSLAVEEFKIVEKECDGKKEHLWISKDLTVSAQGKCRDNVTVTCTEHYQQVEVNSGVLSEMTNLLKTLQKALHETLCLQMYTCQTARLRVNMYIYEMISNSHILSKVFSEAHVGGQSPQEITSEFQADVQRLRDCISVLFMFVRQPLQDQEFADNLYSWMEHLVSILLRVASLADLVFLVNHVMRCPPGFARKVASFIQFPVPRYHGDTNVVGEQYFWDNPLVHHFVAMLAAILLPVRGREEFLQRMMTRSNGTMRSISWTLIDEDGEEDENPENSWMLFQEGDLVEVFGQFPFDSFFKHLFKMDPYLDGEYVSEGSYCIEKTSSRDIMRMLAFASCIVNIMGATFGTYQNVRYRGFVKRVGRTIRQIVQYVLDHWSNYRSWRVDMHQDTYTTIPDMYSLEEQFSLQRLQTEVDQFFMKATQQIICAHNLGAWQFLAGMPFKSVSSPTLWSLFWALHTDLKQMIPVLARNGPQDTGEYDWRTRLQELRSEFTDQLSHMSQSEAVFLLTTFTNMATSRESHEKDFIEAVTLEVFEVSFISDQTREFCSKTGRDLLGTIAGFHPFIFTVLLQRVGESIETIGKAAVYMFNGLPIHLCHPTSADMDVMRGWLLKAELSSPEHQLARHILQNMNWRCSGDQGESDHLFLDHSWHRAVAVMLVEASALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVA1</accession>
    <name>A0A6P8IVA1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116304458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031570055.1">
        <property type="nucleotide sequence ID" value="XM_031714195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVA1"/>
    <dbReference type="GeneID" id="116304458"/>
    <dbReference type="KEGG" id="aten:116304458"/>
    <dbReference type="InParanoid" id="A0A6P8IVA1"/>
    <dbReference type="OrthoDB" id="5969215at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570055.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13770" checksum="CEC197B78316021F" modified="2020-12-02" version="1">MGASLEESIKQLSIDLKQEQELALKSLLESKDLLAILPTGFGKSWIYEAYASIKNAQVVLVVTPLTSIIKDQIAHLNRSGIPSAKLSVLQHEDLNACKFKILFSSAEKALTNEFTSLAEGQLKSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVD3</accession>
    <name>A0A6P8IVD3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304502</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570103.1">
        <property type="nucleotide sequence ID" value="XM_031714243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVD3"/>
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        </source>
    </evidence>
    <sequence length="3513" mass="396684" checksum="511519224501C7B8" modified="2020-12-02" version="1">MDKDNVEKVASCEENAGQVFLLMGREYRISRSIRAQWFFQQFNSILPQPKPQDELLASNEELEILSILPSESFDTATSHRDKTLCLVPSTHMTFIGRRYRFVFCLDVSPSLATVDIQSGDVITDEVFQKLKNCLSALVAPFSVPGNNVILRPELYITIIAYTSILSPETPQILLQGCLITEENLDFILDSIYNKLSKLEDTLAATVALTGESDPKPQSQKTEGDSDSIQNDTITLLSPEAGPISMLRSAILALQLLPDNASAGAVVITDGVFALPDASAVDSLLAQLRASTVCCSFIKVGSGFHAHCSIGYVPHCDLMQFIAMATSGAYLAKAPQVAREAQKDGAHDLPVMNLYHKALLCWSFQKDYDLSKIDSWIGDAINLSEDDLALPLVGVRSTLSYALSEWERNAMQPSMHKKQMESKLHTSITSVISVRLREGYSVQDVSITKGGKQLEVKLTLPWKQHVQIEYTAIAAWPLSRSNRITHVEVTITAPYEFLHDVSYLTKEPFTSGYRAMVVKKFRQTMKNIQSTDELLLHLQSFASNPVYYTIPESAKNGVPLFYLPPNSSNPVLSVQHEKKISKSQESQFAVFWKPVLTLDTTTWQRWMHCHRIGLLLEHDIPLPKNLHLPIGNERFHSIQCRMALSSLNSLLRQMSSFVLLENHSYIKFIEGDTPESPPSSFCLIRVSSRAPCIVIRLAFLGGTPGNVRHMITKEIRSKLIEVTAPIGPISKTTKIQVSQNKSKKRGSQRLAEEKPCVLVLEKPLERVLVRYDRVPEDLFFPYPDVLLYSVYSTNTGLQYANRTNDNHMKVLCHYLYHQRWVWSVQEDEPSHSNAEFVARVLTTLTKLRLQEKFNIACSNAGIITMAREIKMKDHTSNSGQIYPCIVQYVMFPPYSKPTASAVEDWVDEGKTTSPDNKQKLQMVTEVWIEPQFGVIVNDDKALEYLNGLQYFEVPQAIFDIDYKYVSAFLTFERIWRMCDDQVICAPSSSSPNTPSMLPAPSPDRNWTVEAVPYSFDPLLLLPKSRQVEMVFSSIQENTMQDTNGLGEMPNEVLFKLLIEDMNRFHDREIKLTEKNCRDLMKHILKRDRHSVPVPFLEFLKLSKTESSESNGDSVEHCNLDKKPLIKWRCFARPVSGLGYFRLMLSFIPASLKYVKMFGKQKRNSFGGKSKIDPGFKDNGNVLEGVRESLSRRSLTPIMEGVEKRNLTPTPVAEIEQNPFFPDKPHSVPLTLQTELQSTDLTNDNIEEDKAGFDPNPRKMAELTIDVQPEKNVKFKEDDNVLTPTEENVSPMAPNTPGYDDDWLCYSIPIYCYDCPMSTLTNVEQKKEPDERTEEIRKREDIFQDFTQTSHVFVDPFSLEEIPRMAEGRTLGRFGTSKDLLLHCNAVHDIFFRCFVSSIFTSLQSGHQMNIRDVQSAVDTCEENFLEIDITEFIRHLCGHFSNTSQPKTSDSVTSSLLLCQKTQFPIFQGREFQGFGSLLFLKTVLSDVCESAPGLHQSIKERFMGILDKYFKAIPTSGDLYFYCPQSVNVTKKSCTSSSFEPEEDKDGIGFQDNSDKLNDVDDKSDEEVFGDTFVLIQDDDQEYPLSDDSDSDFGSSSEESDFGELEDDDKSLKTPLFLQLTCSLRDRSTIGGGAMTPVSVSSLPVCIGEIISRMEDADTSFDLFSPSLKITIDLNCLTLSPEADHSALRSTASQEYPLRSNSFSSVGSPLSMSPQEKFEFKRQDSKTVTSYDIDGLNGPDPLRSLPNQQRVAMNITCENIQWLLQDEVVSELRHTGPYTTATLDKVERHVQKSVSHPLCIYRNVPLQFVFGAEQSMELFTKEIEEIKIHQYEMSKVDDYYYLTLSDEDSGMSQEDENEQLDGEEESGKEPEPSDDAVVEDDMLSKTKSFFKSGSNSTDITDERSSGQDSSAECPSRLKMNDKKNSPTNLTTDSLEGEAGLGHEEVSEVSGTESDFDERSERHAKQEGPANDETLFEANSTNISKQDVDRPDESLSRATKERLPVKKPTKQESEDSDAVLTPVDLSLPLTVLTSPEEDSCCEQLVTPFSEFPTPVVTTSTPVTIKEDQDKSLDKEQDSSSVISANHKSDILDKDPTLCVGDAEDQEKDFPGKNGCEQPSKSPTTSPRIPSKRREDSSKKVNFWLVLRLCDNYVDIYFHARHSEYTKMSSTQAEGLIETVTNAIHEKCRTVNQQMLLQDLYDTKMCNSLLFPEADEDIWKHEDLRMSVSPTGVYISKSDGSGYLGRYVQGEFIFQPGHFQCLSQWYRHLTFHPRLQDPAGRACNSLGWKIIRGVLDRFGIKNRRDMFVYKESSGRIFYMRLLESLCVTDQSQFPSDELIQDTDDEDRQSRDEALSNTSLIGSRTSSRMSLSKVGQEQDEDVSEPRSNNKRLTVGLPFGDKVEQSIALHVYGVDEPGTEITVDLIEVLNNRLNDATLDNLAFLLSRNPNSKLNYSDVRFIQPPGKLPNAKLAVVIPPLDMGYIYPFFYYLKQNLLQVLHIPRYADLKPRQQFRDPEDNGTCEIFLYNRPHSSGGKGLACISMKVVDRNQDPVHFTVARIPSINVDHLDRNFYEELTRVNMLSDDTYLDDNCIIQFSVWERGNIGLDDQLGKQLKCITQHALCDLLMEYLLLPAPLSSIPPEYQIDISYRLRSLSEPPTPSSISPSSKALRPDTPKLDLXQNKAQKDSESQEISSGTPPQLLTRKISSDSIKSAPGHRRTPSSESQGKEFKTFLEKQGFKGHRRSKSTEIRGKSYIIHQRTNTYDGQEKFYSHSKAAHACLPGDATTISHESLPSQGDIAQPKRKLVYSGKEILSNEDIAKNKKTTPIDIVSKADTKDDMNIAASLEMASEAQEVANDDTDGTQADQTLPAKEEDGLSLGSQSMENYFSEPSRDTAPRDSPSRGVTPDCTETPMRKEDSCLELVSTFETLSHQEILESQEYASQPSTPSAEEKQFQVPTKTTDKTSPESSRPLSSEVKHRGGDASTFSPLSKSVNVTPLLMPTLKDGHETWQDLERRRRTLQEKLKKRMQYEDGERGELHPNFHFPGRELFAFAHSLGTPSVHVTEGQILNRFATDFILNELSSLVVGMCPEMKPRLYRQTPHSHVDDISRNNMDHVCTCPKYKVGREPLKTQNQETSVDQAGRVFVNTPGCPCFYVLIARDHRQWRTSLGLENDLNGDEVSSQSSHSRASGQRFKALESTSPVNVRNQESGSLCSTSTCTIPRQKLILLTFMNKKLILYTYNLAADFNQSLEDQIQRLLHWNNARCHLTTCLMTQKMGLFHHLSFAQINEGKKGKDVNPYCMSANDMDMNALIRKTTPVVSDRDQNTSRSLANANLLVFDQVLRDVVPTRPLQQTPYFQHRDPVKQHGYQFREIRSAQIKANTIQTALEELYVNWQQAPHPPAGVRQKTFLLPIFFSSNFCYSFFSSNYSNSNEMKQIYRILTLASPHSGSSPTEILIGFRSRLLLREENRRTGKNQPTTLFTFDTEYKDRYACFLIPFSFFSFCYIPRTLLIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZS4</accession>
    <name>A0A6P8IZS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein regulatory complex subunit 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031571423.1">
        <property type="nucleotide sequence ID" value="XM_031715563.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IZS4">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="GeneID" id="116305618"/>
    <dbReference type="KEGG" id="aten:116305618"/>
    <dbReference type="InParanoid" id="A0A6P8IZS4"/>
    <dbReference type="OrthoDB" id="61560at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22977">
        <property type="entry name" value="DD_FBXL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22124">
        <property type="entry name" value="F-box_FBXL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001152">
        <property type="entry name" value="F-box and leucine rich repeat protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001681">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571423.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="88751" checksum="C8D0D12593418703" modified="2020-12-02" version="1">MTSLRSCDPELREYLLEHRLPDVFEAILTALAINCPDDPHDFIIEKLNILLTEKXVFDDLRWDTFIEKKLAKRKFALRRRTLDFLWSYEDENSQPTPEMYQRAYNLYNGKLKNSCFKAWLKFHYHMKRKKMILTKKLNDARTWYRLRILKMRLTKWIEWVAIRKERQRAISTRIQRVVTISLLRLVFKAWQGVAADARRTKEYFERIEKGEIIDGGEGGFLAVSAEGPSDQISTLPRHVALRVFSFLSVSDLGRCSRVCRAWKMIVQANILWSKVDMSEVKHRATNKVTSKLVIKCRPFLGHLNLRGCYHLTKESLRIISQCRNLQDLNLSDITGVXDDVMKEIAMGCTSLLYLNIASCQISDSTLRYLARYCTNMQYLSLAYCTKFTNKGLSYMANGKGCHKVVYLDISGCGQITEEGYKYIARGCSNLNTLILNDLPNLRDECVQALTSDCRTLRGISILNSPFLSDTAFKCLATCRRMNRIRIEGNNRITDASVKVLAKSCPLLDHVYLVDCPRLTDLSLKALACCKHLHVINVADCVRVQDTGVRQIVEGPSGSKIKELNLTNCVRVSDVTLLRIAQRCHALVYASFCYCEHVTDAGVELLGTLPSLISLDLSGCNIQDQGVAALGNNPQFRDIILSECSNITDLGLQKMCQQCRMLENFDISHCNRITDNAIKNLAFCCRLLRTLNIAGCTLLTDSSLQYLSGVCHYLESLDLSGCVRVSDKALRYLRKGCRKLNSLTLLYCKNVTKSAVQKLHVKCENVMHSTEDPRDIMSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2J5</accession>
    <name>A0A6P8J2J5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116306381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572288.1">
        <property type="nucleotide sequence ID" value="XM_031716428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2J5"/>
    <dbReference type="GeneID" id="116306381"/>
    <dbReference type="KEGG" id="aten:116306381"/>
    <dbReference type="InParanoid" id="A0A6P8J2J5"/>
    <dbReference type="OrthoDB" id="5963240at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572288.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21738" checksum="C2AA9EDDECAA1E79" modified="2020-12-02" version="1">MPCCKTTNAWVYNLRVGQENRLYTVQLLREIGCCNENYHIFVNGEEHSAHELKYNFCSPLYGRGGKYEWEQDGHHFLLMGNFLSFTKSLGGYRLFIDGIDVNTGREFYTFWLRKGFQVIAIGLVFLLLGAALTIVVLLTTYGNSFVEIVGYILALSGLTYIIIGIIPVIRFRNPSSAYHHTEFEYSPARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J355</accession>
    <name>A0A6P8J355_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Toll-like receptor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116307853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574029.1">
        <property type="nucleotide sequence ID" value="XM_031718169.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J355">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="GeneID" id="116307853"/>
    <dbReference type="KEGG" id="aten:116307853"/>
    <dbReference type="InParanoid" id="A0A6P8J355"/>
    <dbReference type="OrthoDB" id="635273at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031574029.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36526" checksum="1A5422EF063097D4" modified="2020-12-02" version="1">MTVVRCRIRRICELQDLIASKNQVIALDLSSNSLKNITEGALSLFSGIKYLSFAYNDFQVLTYQVFYGLDSLTTLNLSMNPLRTFTGNLSGLFPSLSTLDATGIEHWKPEKNFLHLRMLRSIIGLTWSDECVNCLFFRSHNETQMESYFIIRFCNVVKKGVNVTSPLFQMLNETQFEFRCKNQNLCVRHNYFAFVSSVNICWDAILVAMNCQSFLGGLSVVLNFVXFLNIITSRRLRNNVCMLFVCNMAFSDFLTGLYTIAITVYLNNVSFIQSYRDGDLHCWKIGMSWMLGQASAVSRKLLKMREYKGNPNSPSESLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3L1</accession>
    <name>A0A6P8J3L1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyamine oxidase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031572603.1">
        <property type="nucleotide sequence ID" value="XM_031716743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306664"/>
    <dbReference type="KEGG" id="aten:116306664"/>
    <dbReference type="InParanoid" id="A0A6P8J3L1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027805545" evidence="1">
        <location>
            <begin position="22"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="303"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572603.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49609" checksum="F17052CEDF53A3AB" modified="2020-12-02" version="1">MTKTFLTLLLVAAIASCSVNAAIKKKPHKKVLILGAGLSGIIAGKTLMDNGVDDFLILEGQDYIGGRIKQEAFGGYNIAIGPSWIHYATDEETVPIWNLKKDTNLTGVYSDYTNIIIRNDTGANITDIESFHKLEKILEKVEDKQLERKHAKKTPISARIGLALMGWKPKTAAEKLIEYLDVDFEMGKRAELGPFRELFAREPDFFVTDQRGXWTLYKGIYKTFEDKIKLEKTVTEVKYNSTSVQVKLRHRYVRLSIQSFLETSIILELYRYLKEWAVTRYFEAQLASNKKGFFPVFQDLEKPGKFPEGSGMLLITVAENEGRRIEKQSFEKTKAEIVEMLRGVYGQDVPEPTDIFYPRWFTNPFTRGTFTXSPLGTTSQDITNLAMNLENLYFAGEGTSEDWHGYMQGAYLTGQEKARIISSIIKKQDTEDCHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3Z3</accession>
    <name>A0A6P8J3Z3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chondroitin proteoglycan 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116308100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574329.1">
        <property type="nucleotide sequence ID" value="XM_031718469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3Z3"/>
    <dbReference type="GeneID" id="116308100"/>
    <dbReference type="KEGG" id="aten:116308100"/>
    <dbReference type="InParanoid" id="A0A6P8J3Z3"/>
    <dbReference type="OrthoDB" id="5968206at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028266446" evidence="8">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574329.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14238" checksum="0D7876EEA39C7762" modified="2020-12-02" version="1">MMKLAVILACTLVFYFAIHSAESRDFCYKRDDGDYANPVNCHMYITCSNNIAYYRQCPAKLRWNERTKTCDWPRNVKCHIKPPGHCSDNISLRSCLFLKSHNQCRKDKTVLNVFCRKTCGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J403</accession>
    <name>A0A6P8J403_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase 47</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin thioesterase 47</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-specific-processing protease 47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308476</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031574756.1">
        <property type="nucleotide sequence ID" value="XM_031718896.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J403">
        <property type="interactions" value="2824"/>
    </dbReference>
    <dbReference type="GeneID" id="116308476"/>
    <dbReference type="KEGG" id="aten:116308476"/>
    <dbReference type="InParanoid" id="A0A6P8J403"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045578">
        <property type="entry name" value="USP47_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF702">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25985">
        <property type="entry name" value="Ubiquitin_USP47_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19718">
        <property type="entry name" value="USP47_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="166"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574756.1"/>
        </source>
    </evidence>
    <sequence length="1172" mass="133711" checksum="EDFA72CF08BDFF5F" modified="2020-12-02" version="1">MVIDTSRTLVAVEEGSRAEEPLVLCIIQDETTVDWKNAKYTVNLPASSSVEDLINHVSKEANYVVDSFLLVWTNSSKDEDKEIPLNGITDKSLSDFGLVVGGKKNKFLLKAKDGEEPRKLKDDGDNTNDTLSTMVPESNAASASSYSGSYYSGDSYYTSKSDTGFVGLVNQAMTCYLNSLLQTLYMTPEFRNAIYRWEATGSEEQDIKCIPSQLQKLFLLLQTCDKKAIETTDLTKSFGWDSSEAWHQHDVQELCRVMFDALESKFKSTDQEDLINKLYQGKVKDYVKCLECGNESARTDTYLDIPLAIMPFGENRAFGSVEESLEAFVSHETLSDNNQYFCEKCNKKCDAHKGLKFLSFPYLLTIQLKRFAFDYNTLXRIKLNDRMTFPKFLNLNQFIDDRESSGDDEQSVKGDSPSSTETDSGVSEGYSDNGILTEDEEIGAAGNGDNQRDDQSDEQEEGAVGDQKPSSEEHKGPYVYELFSIMIHSGSANGGHYYAYIKSLDDGCWYCFNDQSVTRVGDEEIERTYGGSEYPKGYYSSIYSSSTNAYMLQYRQVAPQRNKKFMEVNEMPPHIVRLSNAIKNHEEVERQRKEVDKNTCKIKVFYDHPLLRKVLERKLKVHKDKTLSEAVCIASKLFSVDFEYPKEQCRLVKYDEYHEAIEKSFEGEEDTPMGVLLGGVKSSYMLELLLETRKPDETFPVYKPGGITLKVHNVDLEDEKVHPVVNVRVYMNSTLKEIKETIGKKLGISSEKMRIISEASQYELKILDSPNKELKDMGFFKSAKLFVESSGSEEGLLFSDSKFYKVLDCHQHTVKLCVTLPDPTTKPANDELSLHVFEDPKEVVSTVNDKEQDIYVDKRITLSELKEKLVPLVDCDPDFFRVYRVYSNNQEIELTRLNDTLNNFIDETKIVVKYGRALKTGECHIKIYLLKPNDSEEYIKYLFDWVVVKGMNVKKCKELIQPELRKXFDIQTPVQNLRLRKKTWKNPGTVYVDSQTFDEDISIYANFEVFVEELSGPERITSTRLLSVYTCHWRPSSLTFDPLQEIILSDCTGDELKEEISKLSNISLENLDFAKGRGPFPCTTSVLEIDKTLDWNPKTTSLRTSPLYITDDGAVIYYRDKTEEMMEISEEKKQEILKKENAKTSTTAPKTVAFTYKEKALKIYKDGVKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4H1</accession>
    <name>A0A6P8J4H1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 10-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574941.1">
        <property type="nucleotide sequence ID" value="XM_031719081.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J4H1">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="GeneID" id="116308613"/>
    <dbReference type="KEGG" id="aten:116308613"/>
    <dbReference type="InParanoid" id="A0A6P8J4H1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="43"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031574941.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="60786" checksum="5B25851387B343FC" modified="2020-12-02" version="1">MGREQELELKKNKEKLMESKMPTCRDIRCHVRGKLDGGLSWLIVFSSFIQQFIVIGTHNIFGSFYIDLLNEFNKSKAATAWVGSLSFGLSFLLGPLTTAICDKFGIRTVSLIGNALFSLGLLATSFATSISLMYLSYSILVAIGSSFCYYASILILDQYFRKHIVTSNGLALSGAGAGTLALSPVVELLLERYRWRGAMRILSLIASAQFLCSFIQFFIKPPLRIKIDDCDTTNEKKPERKKKFINLSLFKNKAYVLWIIIXSLVLFGFYIPYVHLVRHCQDLNIPKSKGAILIGYLAISQTIGKIVFGRISDHPRVNRIYLYQFCLLVCSVLTTLLPIMTSIESMTFYCWAFGFHDGCFVLLIAVLTGDIVGQENMASAFGMMYFFSCIPMMIGPPVAGAMYGMVGSYEPAFIMAGGLTFIGVCLLFLIPILLPSEIVQQWSMRSTRQEIKPADDDDKIVSAKAHTSFPTYASMKAQDTAPKITLFKEDDRQNRLSLILEQYFSMQQLVNQRDSLLSRMYSSENLYESIPYTAIIRETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4J6</accession>
    <name>A0A6P8J4J6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Steroid 5-alpha-reductase DET2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116308341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574602.1">
        <property type="nucleotide sequence ID" value="XM_031718742.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308341"/>
    <dbReference type="KEGG" id="aten:116308341"/>
    <dbReference type="InParanoid" id="A0A6P8J4J6"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000014">
        <property type="entry name" value="Steroid 5-alpha reductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="156"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574602.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34475" checksum="D846E7C82010B951" modified="2020-12-02" version="1">MAEKVELNFAESWIIKIHFWAFNLVNSTFGTMLEALPWSAFQDDTTHFWVHYGLCIFGFVLAVXTMIVQFSKPAPYGKHXNDNTNWGVMVHQRLAHTLSDAPPGVILFTLVFFLYGVQRXFVNIIFYVLWMCHYIHRGIIHPWIMNYSSAKTPIGIPIAGLFPNFLYSYLNADWISSALYVRDYYKDPRLITGVVLFVIGFCINRAADFKLRNLRSGGNTGYLIPQGCLFKLVSCPNYFGEMLEWFGWAVGTWSAAGLVWFLFGCGTFVPRAKQNHNWYKERFPDYPKDRKALIPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6D8</accession>
    <name>A0A6P8J6D8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Synaptobrevin homolog YKT6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116307373</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573463.1">
        <property type="nucleotide sequence ID" value="XM_031717603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6D8"/>
    <dbReference type="FunCoup" id="A0A6P8J6D8">
        <property type="interactions" value="2997"/>
    </dbReference>
    <dbReference type="GeneID" id="116307373"/>
    <dbReference type="KEGG" id="aten:116307373"/>
    <dbReference type="InParanoid" id="A0A6P8J6D8"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="14">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031573463.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22572" checksum="6EE9D47E93ABFD56" modified="2020-12-02" version="1">MKLFALCIFHKDVNVKLLVSAFDLQSFGYFQRSSVKEFMQFTSKILVERTRPNERATVKEQEYLCHVYVRMDSLGACLIADGEYPRRVAFTFLNKILEEFSKTVPQSVWRSAAHDSVEFPACAENLEKYQNPKEADAMSKVQSELDETKIVLHSTIEAVLERGEKLDDLVEKSEGLSMQSKTFYKTAKKTNSCCSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6E5</accession>
    <name>A0A6P8J6E5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572890.1">
        <property type="nucleotide sequence ID" value="XM_031717030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6E5"/>
    <dbReference type="GeneID" id="116306899"/>
    <dbReference type="KEGG" id="aten:116306899"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF450">
        <property type="entry name" value="KELCH-LIKE PROTEIN DIABLO"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572890.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="69999" checksum="95260F8628D5840D" modified="2020-12-02" version="1">MYHQSVYTQSEAHCVAYKQSPIRITNSLLYPSFVIVVYQSLRSLLSTMDSTTTSEGQVSSLQHFSSLAFEQFQCFRSNQELCDVFLSVDGVHIPAHRLVLAASSPYFRAMFSGKMAESVQKEVFLSDLDGKAVEKIIDFFYSGKVAIDEDNVQSLLYASCLLAVKDVKEYCCDFLQREITVSNCLGIRAIADTLSCSELFEAANLYVTENFSVVLVCEEFLLQPFESLSTLIDSDYLNISGECELLDAVVKWLHWDNLDRARYARSLLKRIYLMKIHVSRLESLLNDSIISTDCECLDLILEALDTLASENVSSAYEFPLFLSRVYGKAMEVLFSIGGESAGVTLDSTECYDLKGNTWDWNISVRDLEPLSLPALEQSRNNATSSTTGRHVYVIGGSYSWKALDVVERYEWPENKWRQLSSLNKGRLGAGSAIVNGQLLVAGGCGEDGYLSSVESYDPLLDKWSLIKPMNQRRSYLGVAELNGYVYAVGGYCGVSGESDGFMASAECYVPSNDMWIPVTPLLQPRAHFGLVAEGGSLYALGGYNSSWLTSLERFDPREGQWYRFPSMKSPRSSAGACSINNCLYIAGGFDGVKNLNSVESFDIRAEKWKQMNPMRTVRFGMCLAACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7M2</accession>
    <name>A0A6P8J7M2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307681</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573818.1">
        <property type="nucleotide sequence ID" value="XM_031717958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J7M2"/>
    <dbReference type="GeneID" id="116307681"/>
    <dbReference type="KEGG" id="aten:116307681"/>
    <dbReference type="InParanoid" id="A0A6P8J7M2"/>
    <dbReference type="OrthoDB" id="5980787at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573818.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="62404" checksum="6A2FE5847DF7A998" modified="2020-12-02" version="1">METSRETAELCRISQLSLSENPTDQKIERVSSLNKSGYSSHGSQMETDNFSSDEKGAPRYMEDDEEYQSGTNIIRSGKNDFINIYNNTGTVIIDLGCGAEHKGGNLTERERTISRRPFPDSARSLASSMNIKRKKSAKLKSKRRLRQTLLPFPNRKSKMKVKPSSEKIKEVNISVDNNSGNIVIGDSAACHASTSEDPSRIRHLEGEQVVADGTEIIAVSPPKQMVVCVDRSIMKWLHQFYEITNQIYPLRDNGRWEEFYETVDKRIHFARQNGQFEEEIFMTIEKSTALSYQKKNEQSMEVVKQANDMITRTRGLQMKEFLTVMSHCQLAAIYRREQKMFKANHAVVIAGQNAEFVPSYLAKAYAMYERASNQAMYISIVSTQQPEREEYEKDTREDHRSCISLCEKLLSESDDIYLRRHHFCFLKLALMNLNCRNENARIQPVSEDSVREANECITRMQELYSGEMSEATNILLLTVQSDYKYRTGDYSTAMVFAEEALKISERRGFELEIKELQERLKLLEEHQHRRLANATEICELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J8W8</accession>
    <name>A0A6P8J8W8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin-related receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116307338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573385.1">
        <property type="nucleotide sequence ID" value="XM_031717525.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J8W8">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="GeneID" id="116307338"/>
    <dbReference type="KEGG" id="aten:116307338"/>
    <dbReference type="InParanoid" id="A0A6P8J8W8"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031573385.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37145" checksum="0A1A5FFB12A2405C" modified="2020-12-02" version="1">MSYFQGSGEWTLASVVVMSIWLTVIILVGVVGNILVIIVSLQGTRVRTRGKGLIASMAFADMLESVNMIFMLVTVTQYGEWIFGELMCTLHGFVTTLFVIASMYSLMTISINRYFXVVKSNHYKKIFSARKLSLMILFIWIFPLFFAVPPLFGWSKYVFQSNKATCIFYFSSSVGFSISLMAFCIPLPLSIIIFCCYKIYKQVKQHRSQVEAMGTEKSVNVEEIRITKTLIIIILAYLICFIPPAVVNLIEMASPMYKIPFWVDIITMNLIFANHANNPIIYGVFNRQYRRAFKELLIGLIPGMHYNSSLDTSVQGNAGLNTSVYATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9X7</accession>
    <name>A0A6P8J9X7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Amiloride-sensitive sodium channel subunit gamma-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116307497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573625.1">
        <property type="nucleotide sequence ID" value="XM_031717765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J9X7"/>
    <dbReference type="FunCoup" id="A0A6P8J9X7">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="GeneID" id="116307497"/>
    <dbReference type="KEGG" id="aten:116307497"/>
    <dbReference type="InParanoid" id="A0A6P8J9X7"/>
    <dbReference type="OrthoDB" id="5971051at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031573625.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="50441" checksum="63645862BA6D4013" modified="2020-12-02" version="1">MDQFINPNKTFNEIDQEEQDAEDNSNTLLRRRREIKLNVTQPKKKFTISNKGKVEGHVDADLPDPSQLQPEYRVKERIYVQLAELTHEELKPLGHEFDESLLACSFRGVDCLNFTAFWHSFWHYKYGNCYVFNSGRDRPVLRSTKAGPLHGIEMQLYVKQEEYVDQLSQEAGYRIVISPQGEMPFPFEEGISVAPGQSMSIGIRKVVIKRADPFKNGSCGASRELRPGNLYRSAYNAKYSAMACRESCLAYNQLFRCGCLEYRFPEEGFEVCDSTNKTIVNCLRRLHVQYQNNGLNCSKACPISCNEEHYKTSSSSAAWPFKNYEIYLKKMLNIEEESSEILRQEMLKVKIFYEELNYQEIEENVSYDINDFLSDIGGQLGLWLGVSVLTGVEVIELILMIFLNCWQPKKKAAATDIENHEMRAKVGEPHKHPFGYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAB8</accession>
    <name>A0A6P8JAB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574698.1">
        <property type="nucleotide sequence ID" value="XM_031718838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JAB8"/>
    <dbReference type="GeneID" id="116308423"/>
    <dbReference type="KEGG" id="aten:116308423"/>
    <dbReference type="InParanoid" id="A0A6P8JAB8"/>
    <dbReference type="OrthoDB" id="6579237at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026700">
        <property type="entry name" value="CCDC142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055350">
        <property type="entry name" value="CCDC142_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21436">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21436:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14923">
        <property type="entry name" value="CCDC142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil protein 142 C-terminal" evidence="2">
        <location>
            <begin position="497"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574698.1"/>
        </source>
    </evidence>
    <sequence length="963" mass="109496" checksum="DB537270FF6ED37F" modified="2020-12-02" version="1">MDEREKGSKHSKARLSTLSDRHISTAGAQANDEVSSQRDASQTILTMDIEESMPVLKETFKSISGEICLCSSQQQGRKYFGHFEMGTRMNSSVKQIEKRIEERLGLTLMKDCLLRLQASLEFVSELENTMENYLSYYKDLKEKGTELERDFLFNGHRFHDLCLTAKDHLTFWSLFTERCSSETTVKYTSPRLQSDLQWVHKALLRVISRFTTLISTILVYVLDIACFQQWQLSDGLLKDISSAIEDLNRLLEYSRSVLNENDVLFKLSSANSFSDSTVCKLFGFCATVRQIPSSNVYPVTLGKLFQGTAKRRARVLGGHVLSFVHQRQEISGNLKSDLVRKLEWKDLNTVNIDHKKLDQGNGVVTVRSKNHVPQVKLDPNSPLVSFESIEYQFITELISKLATSNSLMSTHGIDKKLHMHKSLPQKGLYHTDNEETQDQMGEGTIPAHDNEPEAGHSILKHSTGSVSPRLSKRVQWHHSIDMDSKAQVSALYMDIFWSSYSIVICQMMEVLGWERNYKGIRGPLPLWSDDIIMSVVRGLESLQLSESLPPDGSKALQLVSRYILCIGAMSSWDQGFCDLISIAQKDKCTSSNKPDDCSPSTKTVEAIINLLHPMMSIFEAAQKWTTHYTGSNNNCTIYMFKDLSCSVLPILSRMQAILSFTQYWLETKLYHFLSGWTLSPFFMLLHWDLPILVRVLSMTVDKVRPLCVGQGGNYSWGLLPVQLEELQEILSRIKHLITEYNQLFEDDLRKMSSEFFQEAMPVGKVWKKSRQSGIPCQPNSYVEHSITQILEPVIYGASLLPMDSQLKLLALATTIMMEAWSAYILKEEIIFSFYGAQQMQLDFNYIKCWISSDASGLSTEMQSHLLGLETFHHLDGATRLLMLQPRKKKQMDELDVELESNISAVSSSSVLSSFSGVDIDSYEIDVLNDKTIPNKQHWLDLRLRGGKTKKGLMPFCLKVQETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JC63</accession>
    <name>A0A6P8JC63_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAX3- and PAX7-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116308860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575223.1">
        <property type="nucleotide sequence ID" value="XM_031719363.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8JC63">
        <property type="interactions" value="3239"/>
    </dbReference>
    <dbReference type="GeneID" id="116308860"/>
    <dbReference type="KEGG" id="aten:116308860"/>
    <dbReference type="InParanoid" id="A0A6P8JC63"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="6">
        <location>
            <begin position="560"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="263"/>
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        <location>
            <begin position="264"/>
            <end position="274"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010801"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF07842"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031575223.1"/>
        </source>
    </evidence>
    <sequence length="876" mass="100442" checksum="B4038305B83C730F" modified="2020-12-02" version="1">MAAMFRKSKRNFRKKNLELNEEEDDANENESTENINAITTGKLAEKVKSKAKIEKVASTSSLLSFDHDDEEEVFQVRKSKESRKLSKKAKSKKEKQKDKGREGENVDGQSRLESPENDNIADIKLAALRAELNQMSKLDEDEDDDGEESDNSQENKEASSNSLAAVRQHQFNIPDAATIHALKKKREMARQSGTGQDFIPLDDTKRFSGRFDSASRLVREDENDASDDEDGPISFNAVKTQDNNFYMKDEDNENEEGEDEEDEETKRWENEQIRKGVSASQAQQDKEPQSYGVQNLSISQESYQKSSLFNQNVYPYGGEYGQESTQQKYNGSHLPGQIRSSKSQVVTMETVWDAMNKRLESLNEVHRGHCMEQDKITEHQRVSEESIENLIRRGVEAERQYGFYQEMRGYVRDLIECLNEKATAIDAAERSMSDLLKQRAQRLVERRQEDVKDQADEFLSLQSGKQNQNVKPIIDEFGRDMTMYVEERKKRRAADREGRRMRRRRNREITGSNTAHHEGMSTDEEETETDSRQLKSESERIIQESRTLFEDVIEDFSSIEKVKSKFEKWKNVCEDSYKNAYISLCLPKLFTMFVRLELLGWNPLNEDALDIEQXSWYNSLIGFGFHEHEDIDPKDDDIKIIPSIIEKAVLTKLTGLVQHVWDPLSSKQTERLIQLLKNLSDDFPTVQADNKTTQQLFSAIVTRLKKAVNEDVYVPLYPKQLLENKSSGVLEFFQRQYWSCYKLFCNILLWDGLLSSGAIQQLALDGLLNRYLILGLQHSTLYYDSLEKCKMITNTIPRPWLTLLTDSTLPTLETFARFLVNLASCLQRSSAGCSDSEKKKARSGCKKIVQHLNSLKAKAKAKAVAAEHALGEVGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCF7</accession>
    <name>A0A6P8JCF7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase/endoribonuclease ire-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575283.1">
        <property type="nucleotide sequence ID" value="XM_031719423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCF7"/>
    <dbReference type="GeneID" id="116308903"/>
    <dbReference type="KEGG" id="aten:116308903"/>
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    <dbReference type="OrthoDB" id="63989at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IRE1/2-like"/>
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        <property type="entry name" value="KEN_sf"/>
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        <property type="entry name" value="IRE1-RELATED"/>
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        <property type="entry name" value="Ribonuc_2-5A"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="KEN" evidence="4">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575283.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20531" checksum="02380BEF5ACB38D5" modified="2020-12-02" version="1">MLKKSVGERISPTDALAHPLFWTNSKKKDFLVAVGNQPEFESWPSKRNFPETDLERDLKSLKVFQTVVKCGSWDDSRNKLMPKFYDEMKTWRNYDTTSVVDLVRLIRNGYSHYDSLSHKVRRMLLTNYAYLDYFPDLVMEVYKAVTVRGWNSRPQIKDAMTKQEHASSRDFNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCY1</accession>
    <name>A0A6P8JCY1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116309055</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
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        <property type="nucleotide sequence ID" value="XM_031719588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCY1"/>
    <dbReference type="GeneID" id="116309055"/>
    <dbReference type="KEGG" id="aten:116309055"/>
    <dbReference type="InParanoid" id="A0A6P8JCY1"/>
    <dbReference type="OrthoDB" id="5957492at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="20">
        <location>
            <begin position="57"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="378"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="487"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="688"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="831"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="694"/>
            <end position="702"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="107"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="144"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031575448.1"/>
        </source>
    </evidence>
    <sequence length="988" mass="110248" checksum="316885F75CBA3F96" modified="2020-12-02" version="1">MAWIREFPARSFNKNVLGIINRMSFKMHLSMNARICKIIFLFLLVVHNLSVYTRAESVHVITVPKKISSSQWTWNWKATGPTGGGVDQWKNAWPNGDISKPVQYSVCDASPNTPKANQWLTSTDISSGLANRIDIIIEYAMSDCSVINNQYCRQNFSLYLHESPTQLPDKSFPNPYTNLGIFEKIGTSSPKVLTTGSLDQAQRNKETFSAMVNKPYAYLALYYQGGCVKLFSVSVQYYQCPSIKLSSNLVQLPQTIAPANNSTKVKGSCSSAQHLKPLTNESDLYGYCQDDGEWSTDRYHGECGCDYGYGKVATVSGGSECRACPLGTYSDKVSNSNCATCPLNSEQDSSRTSCDCKPNFYRTDKQTKFDSCAGQPSAPQGLSITFLNASFVTVTWSPPTDNGGRTDLYYTAECKQCNDQGTECIQECTGSNITVNQNSRLASINSLSAYTNYQLKVYAKNGVSKLAEEKNDLAKFAEYIIRTKESVPGIPVVTVKQLSSTSVLLSWEVEEKNGVITYYQVSYYPVDHPSNVKKFNTTSTNASITGLETGKKYMFQVQASSPIGLGPSASQTMVVADNQEKQRADVTVPILGTMVGILLFGIAVLVIVYFVRKRGRRRASATSSSLDQKQTVKFAPPPKDPNMNNGIVFLEGFNNPQESHDQETPESRDDLYMVVPDDANWEVPRENISVIKRLGSGNFGYVDKAIAIGLPGIPGQVMVAVKTLKENVKLRDKEDFLTELNLMMRMAPHRHVVRLYGCCTIPGGPQSIILEYLPYGDLLGYLRRSRGHEDSYCSGDLRPESRLKSKDLLRFGWMIADGMSFLADNKCVHRDLAARNVLVGENKICKISDLGLARKVSEDIYTRSSRARLPVKWMPPESIFFGQSTIASDVWAYGIVLWELFTLGDSPYPGCNGNDVTRLLREGYRMPKPPHLSKILYSLMLKCWKDKPEERPPFNTIREEINTYFKATEDYINLDVFEDSLYVNFDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JGS4</accession>
    <name>A0A6P8JGS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC116309050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116309050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575440.1">
        <property type="nucleotide sequence ID" value="XM_031719580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116309050"/>
    <dbReference type="KEGG" id="aten:116309050"/>
    <dbReference type="InParanoid" id="A0A6P8JGS4"/>
    <dbReference type="OrthoDB" id="5971504at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575440.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35590" checksum="BE3FF0DB8A3FB43B" modified="2020-12-02" version="1">MADVKVFLNSSLPVGTVDRETETLRLLDPEGVEIRLRXKLMRRQYKAPGPNFIWHIDGYDKLKPFGFCIHAAIDGYSRKVLWLSVGSSNNDPKVIAKYFIYYVRQVDGIPRVIRGDAGTGNGDVAGIXRFFRRSGTDEFAGEKSFLYGKSVSNQRIEAWWSTLRKTNCDWLINFFKDLRDRGDYCDADPIHAECLKFCFMDVIQKELDDVMNWNLHRIRSQNVESPSGRPDVLYFLQGLEDTQDYKMVVLEEDLGIVDESCCRQVPKCSKEFEEIAEILMTEHDPHSPNDDEEALILYFELLQQIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8RAC7</accession>
    <name>A0A1D8RAC7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116305141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116305141</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="BMC Genomics" volume="17" first="850" last="850">
            <title>Insights into the innate immunome of actiniarians using a comparative genomic approach.</title>
            <authorList>
                <person name="van der Burg C.A."/>
                <person name="Prentis P.J."/>
                <person name="Surm J.M."/>
                <person name="Pavasovic A."/>
            </authorList>
            <dbReference type="PubMed" id="27806695"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KU710364">
        <property type="protein sequence ID" value="AOW69250.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031570845.1">
        <property type="nucleotide sequence ID" value="XM_031714985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8RAC7"/>
    <dbReference type="GeneID" id="116305141"/>
    <dbReference type="KEGG" id="aten:116305141"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF68">
        <property type="entry name" value="AT02704P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Roc" evidence="5">
        <location>
            <begin position="330"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1251"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1258"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOW69250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570845.1"/>
        </source>
    </evidence>
    <sequence length="1275" mass="142416" checksum="FFD1B440FE3E5DC4" modified="2017-01-18" version="1">MGLKEIILEKNVSLEEAKKLLEENSSSEKLQLRNCTKLTYDDIVSLIELINPELTALSINSCKYFNDELLDKIVDHCTRLSCVTFNGNFKDITNVGIGNLTKKCHELKSLSVLSCESDDADDNDGEWTIDDGLLSAIIDTREISLEHFGLSGFNNITSDGLRKFIKHISGSLISLDLSELPAITDKLLHDIAKLCPKLTSINFGYCNLKDKEIESFCSKCTLLQSIDLCGCNELTDKSVFSLSKHCHSLKIIKLGWCLKITEKSLEALSTNCLHLEHIDIRHCSVKHIPYDFVKLSFLKELLVEGCTGLKCPSLEVTMKGVSATKQFLEDSNLHCMCRLAFIGDEGSGKSSLSLCVVSSSLAVADSSTEGVNVSRWRPFSGKEDEAVDKDTLGMPVNDECKDLTIEVWDCGGRKCIQGLHPLFFTDQTLYVLTFDINNPMEIKNMPNWLFLVQTKTPGCPLIVVGTHADGSSTDFSEISKQVLNTLKNAEEEHYLEVRAELDVLKTTGKREDSFICARIQKLEQLLNCRPRLPDKVLYVSSIKGKGISEVQNEIFRHLLDPSLFPHLTEKININLTYLYSEVLRLRQEKIVVIPWDQYLKLASESGITDPEEVQSATAVLECRGCITVFRIPARTQDLGPTRTVCVNPSVLLDCLACMHNETEPREFVPRFIKAGFLERFWPTNTKPNDWTLRSAIDDIVSKGLIREAVIPLCFQAMHLEEEEMLKILAFCRNIGVLVEGAPKGSYEVELVLAYYKNLSVFKRYFLPLQNKLPADTKTPEVWPSGVPEGHIQVGWRFKFPDEVSSNCSTLIIAACRNYKMSSDIYCYCQRCLVLKVGDVMVKISRDGSYLDMIGRCKILHGSKQALNMTWFILAQFFYVTDTLLLNYSGLSPEIMVPLYGCSRPKHKSLFELVKDYNVQPSHLANYRWFLPPGGLDAEEHTQIPSDTSTWLATIAKKSTLFISYQSDHQDEVKLLRVSLEHSGFNCVGEWTLVGQGQELTEKRRQSIMGSSLLLAFVTPDYLKWSRAQQDINLALENHKPVIALLFDKTSWPVDNELETKLKSHAICLDFDAGFGEALSHQYDQAQLTKLVTQCNGILYGTGDIHPPEPPVSPDNTFHIQNESNLRILHRQSSPTNHKEDTRKTSLINHEKSKELEKRAEILSFSKPHIADIVEPEESEETQVQRMAASAVAAAVAGATAQHISKADNSPEAVKAAAAAAEVAQAVVDGNSDAAAKAVVKVAKIVEEISKNQSHSKHMSNGSVSTPPRSSTCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYK1</accession>
    <name>A0A6P8GYK1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116286842</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116286842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031549289.1">
        <property type="nucleotide sequence ID" value="XM_031693429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GYK1"/>
    <dbReference type="KEGG" id="aten:116286842"/>
    <dbReference type="InParanoid" id="A0A6P8GYK1"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
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        <property type="entry name" value="FA58C"/>
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    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
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        <property type="match status" value="4"/>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028118836" evidence="4">
        <location>
            <begin position="30"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="181"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="329"/>
            <end position="477"/>
        </location>
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            <begin position="480"/>
            <end position="625"/>
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            <begin position="629"/>
            <end position="722"/>
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        <location>
            <begin position="727"/>
            <end position="819"/>
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            <begin position="824"/>
            <end position="925"/>
        </location>
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            <begin position="912"/>
            <end position="1003"/>
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        <location>
            <begin position="1060"/>
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            <begin position="1153"/>
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        <location>
            <begin position="1070"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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        <source>
            <dbReference type="RefSeq" id="XP_031549289.1"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132304" checksum="01BB307A449ECE0F" modified="2020-12-02" version="1">MAIQILRMPHFLPLLMAILFLDNLVKVDADCHSTPVGLENMYIIPNISFTASSFYDNKYIPYNARLNGYNGWSPKLANRENEYLQVDLGYPYVICAIATQGSSLKTEWVTQYRIMTSVYGTEWVAYKENSQVKNFTGNTDQNTIVKNRVNKPLARYVRIFPTKYRIWSTMRIELFGYPEACDNLPLGMESDVLQNITASSGQDPAKNARLNYTSGSSWCASTSDSDPYLQIDLGSFHLFCAVATQGNSMADQWVKTYQINTSTDGTTWTTYQENNIDRVFWGNFDRSTVVRQVLFYGTVLRYIRIIPKTHQTTPCLRTEIYGYQVNQTCSSHSLGIPSSKRVLNHRISTTSYYNSEHQPSMGRLGSDSAWGPEKQKGDDYLQIDVGAVSYMCSIASQGNGNNKLHEWVTKYEVLYSTTNNQYITYSENGTDKEFPGNTDQSTIVTNSIKNPFKAKFIRIRPKDFNRWKSIRVDFKGLSAACGTSLGLENSHIPDSRITSSSSLDNSHAASHGRLYGSSSWCSSSSSNTEYIQVDLGEAKTVTGIATQGDKDLDKWVTSYKMGYSFDNRYWYKYKEEKLIKVFNGNKNRTDVIVNWLSNPTAARYVKIFPQSSNGGVCLRLDLYGCTFYTPEKPSTPVTADKKSASLRWTNIQTNQGTADSFSIVVSDTYGTNQTIIVPNQPTTSKEITNLKPYTNYEAKIIGVRNHGQPLWQSTSRFRTLIAEPEASPAIETLIAISSRSIKVTIKFTQRDELNGPLAGYRILYRPEGGEEMQTDVGIVTMVTLTNLKKYTVYSISVAVKNTMFVGPASVTKQKKTLEDVPEIGPKNTRAKKVNATTCLVTWQPLTDKQSNGVITKYEIIWHLDTNRPQSNAARQEFLTASTKESQFRIEKLKPNEKYTVLVRGYTSVGPGPNSTVSFLTNTSKTKSSTSSLCTSEGNAITLGCLTSNEQTGSVRFTWTKNDVVVDDDSASKIEGNKLVLKSVKDEDFGTYVCNATNSEKTVTFTTSRHEVKECSDAGVSIMYFILPLLSIIVVMVICIAYLICRLRRNKENSEAQNLMADPSDNQALESDVSQVQSSSDAVAKPLKPPEQVTQDDSQSVQNYAQVSLMPGGTSTVYETLDDAARAAKEEANKETKTTEYMELQPVIQPAYESLHRGEESQAPAQHYEKIPGYENLAKKSSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYK2</accession>
    <name>A0A6P8GYK2_ACTTE</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116286286</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286286</name>
    </gene>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="KEGG" id="aten:116286286"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
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        <property type="entry name" value="PROTEIN CBG10425"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
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            <begin position="1"/>
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            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="PROSITE" id="PS50157"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031548608.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="69243" checksum="BE669F30BA747FB9" modified="2020-12-02" version="1">KQESCGGNDKQANDGNATWSVDPRSIDRLPEDEQSQIPEYRRHWGYIRTRFSRKNKLLNWYNYRLQSLHSGGLIEHLEQVFNDQDTVFKLNIAFGFILRNIENNQLQYHYSSRNNDNVFDEPFQISTAADLQPVRDGLQNLDVLEWARQHRPNSKWIVEQVTNVTYFVTKVINHPIGRGKRLPHYXVENRGITPLDCNFRTGRPYVYEDNLCFFRALALHNGAHLKNLERDTKHYFERYRDLFLTDQDFQGVTTDDLSDLEKLFEVNIFVXTLELSHSDDDELIPEIIAKLVTRSYRNYGSTLYLNMYEGHFSYINDVKKYSKSFSCSRCGKYFKSDYGQRRHERRCEAKVRYQFPGGFYKIPKNIFDHLEDEGIGIPQHLKFFPYRATFDFECFFDRNDNPDGTEKMLWEAKHVPVSVXXCSNVPGYDQPRCFVSTGDSKLLVQEMVDYLXTISMESYRLMKEQFDGVFTGIENRLKEKKATPILNETDSEEEHNGIDVMSSDNDDDEEDIESETEEDRSFINDEDSMAEEEPSFYRALNQELXERRPVLRNIEKTENKRQHPLLKLKVIFMISSIWYTFYVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2M2</accession>
    <name>A0A6P8H2M2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SWI/SNF complex subunit SMARCC2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031693806.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="aten:116287162"/>
    <dbReference type="InParanoid" id="A0A6P8H2M2"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032450">
        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16496">
        <property type="entry name" value="SWIRM-assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="446"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="615"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="618"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="915"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="943"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031549666.1"/>
        </source>
    </evidence>
    <sequence length="1140" mass="125708" checksum="0F9E61B66A84A061" modified="2020-12-02" version="1">MAVRKKHGGPDWKYYESPETVALFEPVKQYLLKNHKKYVQVEPPTNKGLATLVAQLLQFQEDNFGNNVAKPLLTKLPMKLFQDFSSGGGLCTILGSVYKTRMEQGWRRVDFQSPSRMDRNVELFLNIEKALKEYKLLVIPQVFFAPDVEPKLIGNLKDIVKRHNGAVVEDKALATHVVHGPPPPMPEEDWLRPLKKQDDRVLVHWWYYPDSYDTWVSSSDVVDEPQEEPTHKGPWQVNARWLTDLDEFNEWMNEEDYELTQSEIESGSVGTTSPSLSRRKSFRSGASSDEPSSPDSALKAKKRKRSPSPESKKKKKSGPGTSGIVKPPELKEEDSEDATKELPDPTPVPNVEEVPIPSSSKAKEAELQTVKGGTLTDLTENSASGKSDKASEADETEEHTEEPDSVAAAVQEETSSHSQPDIFKEPLTLPDAEPHDENLTEQTHHIIIPSYASWFDYNSIHAIEKRALPEFFNSQNKSKTPEIYLALRNFMLDAYRLNPTEYLTATACRRNLAGDVCAIIRTHAFLEQWGLINYQVDADARPAPMGPPSTSHFHVMADTPAGLQPLQTPKSMASVSQQMMHFKDEPISKDVSKSPASSTNFGLHTDQYLSKKSQKAATATKEWTDQETLLLLEGMEMYKDDWNKVAEHVGTRTQDECILHFLRLPIEDPYLEDMKLGPLSFQPVPFSQQGNPIMSTVAFLASVVDPRVASAAAKAALEEFSKMKDEIPESVIDSHVKKAATTKQTSIAKEEPIGDDVKTGEEPMETDDVSKLTSGEANILDKDDESSKDEEAFESALEMNGEGEPSKKTKAADTKEGNIATAAAAALAAAAVKAKHLAQVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLSERQQFHQDQIRAAELRARAGYMASPITPSSQQQNAPQANGVPQPRTPQPVQPTQPNQPQQAQPQAPPLQQQQQPPPAQTQKPKQPQLNPQQLQQKFSQQQQQQQHSTNQPQMGTPQLPGASQQQQSYIQQQFQMLQQQQQTEQAGRPQPQMHGVQGSTPSQTNVSSPAAAASPNINPGSVNSIGSHPASGCSTPASYLGSAAASPAPQGHGPGTPGGMTSGPLGQMQIGGADGMGSHGSSPATPASGTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H325</accession>
    <name>A0A6P8H325_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Counting factor associated protein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549846.1">
        <property type="nucleotide sequence ID" value="XM_031693986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287319"/>
    <dbReference type="KEGG" id="aten:116287319"/>
    <dbReference type="InParanoid" id="A0A6P8H325"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="284"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="474"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549846.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="84853" checksum="41700A296ECE757A" modified="2020-12-02" version="1">MPAYWKIIVTAFLLTVATAGTYVYLKRDDFRSYISEIISKRELKIGDNLASLHFPEEYHSTGVLHLVTSNINEPFEIWYSQSRKKSRIDYYNGDVKTFQRGDIGRYGMFFKIVPKYSYKSKKHWKGCWKRYGVKKRKINAQTILPHNASWPFRSKINDFKYAGDKRIKGKLCTKWTYKVNVLDKKNSYVFYATKTDPPLPVRLEMNGYDTLLVSYYDSYVIDYLSFEKWKYDXKKFQIPHLHHDKWCWDTSKMSRSGDGASASLNPMSEFTSVGHEADPIEQDFNDFKNEHRKVYKDVKEHQKRKHIFRHNVRYIRSMNRRNLNYRLSANHFADLTDKEFNFYKGDMGDNDDDDDKGQEDINDDDDYYYHSHDEAPTDDEKPSDDRRDDDDEKHKHDDDDDDQSKYDNNDERYHNDDXDRDTQRDDKRDERHRHDEDDSYHSNFGSSRDSKSYRRNHISNRHKKNKKLKEEFKIPDELDWRKYGAVNPPKGQGTCGSCWAFAAAGAIEGANFIKTGKLENLSEQQLLDCTWFTPGADKGNNGCLGGWTWKAFSWVKKFGLAKTKSYGPYRGQEGFCKLKNVTIGARIHSYRRVKHYNRIALKKALSFHGPATISINANPKTLKFYSKGVLDDISCSNKTDHAVLLIGYGKHGGIPYWLVKNSWSHKWGNHGFIKIKQGLCGIEKRPFVVLNKSNKPLPWQKDKSAKKDKIFLSKRHRYHQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H355</accession>
    <name>A0A6P8H355_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116287505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550048.1">
        <property type="nucleotide sequence ID" value="XM_031694188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H355"/>
    <dbReference type="GeneID" id="116287505"/>
    <dbReference type="KEGG" id="aten:116287505"/>
    <dbReference type="InParanoid" id="A0A6P8H355"/>
    <dbReference type="OrthoDB" id="5963485at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="42"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031550048.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37544" checksum="587E066A2AB678F8" modified="2020-12-02" version="1">MTNKTGNSESLFDALRLFHRSDSIAIFEGSVGLFILIVDLLCNLVVCVIFVQHKETANAFNVYSLSLAVADIILSAVAMPFSVLALFKGYWDFGSAWCTIQGVVAVWSCEASILTMTLAALHRYTKMLRTPFHKRLYTKGFIIKSIIFAWVLAIMGPVIYLLKGSSFAFVPAFAICTFDYYALDTTFAALMVIFLSIIPFNIILFCYLKVWRFVQAHKAAMSMRQVPTEEIRLNKLVGAIVFSFVLCWTPLVVVVFIIAFQGVLFVPREVCLFAIFMASTSSCLNPIIYTAFFRDAKKIFCRKIRCCCKLRAVSQIGPKLESTKIEMKNTSAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3N3</accession>
    <name>A0A6P8H3N3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116288350</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550979.1">
        <property type="nucleotide sequence ID" value="XM_031695119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3N3"/>
    <dbReference type="GeneID" id="116288350"/>
    <dbReference type="KEGG" id="aten:116288350"/>
    <dbReference type="InParanoid" id="A0A6P8H3N3"/>
    <dbReference type="OrthoDB" id="5954031at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550979.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67750" checksum="EB5799AA87800523" modified="2020-12-02" version="1">MANNNIFHAVEDILQGLSVRKAAKKWCIPRSTLHDRVIGKVVNCKAGRKQILSPAEESRFAAWLIERSRLGFGVSKEEFLDAVKSFVTKTDRKTIFKQNRPGNKWYRGFLKRNPQVKLRAARPLDKKRAKITPGDLDKWFADYEKFMHQVGLSNRPCQIWNCDETGFDLQGRAGKVMGPSEDKDQPYRVVTGTKEHITVLPCFNAIGQCIPPYILYAGKRAPNNYNPLEGGVPGSVFSLTEKGYMTAETFYMWLANHFIPNIPPARPVVLLFDSAECHIDLETFELAKKNHVYLYALLKNATHLNQPADVGVFGAMKQSWYKNVRKFSQQNPNTDISKRNFCYVFKDTWDEVMRPSLLIDAFKKSGIYPIKREQISNDKVKTSAVYEQQQNTPRTPPSDIAQQAKPYTESQLDVALSLLSTFKETPFPGAAHAEERAVPSNSTLEAFESNLKTPVKEKYRRRIEEGYDLPGSPTFKAWKSLYTLSGPIKPQNIQPQDRPMEVIAMQHDFSDKSSLAFDEILSYPSQPSTGNTKERKKSAKKTIPNFLNSEASMAILRDEKLKKAREVAVKQQKLKEKVEMRENRKKEQEEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H448</accession>
    <name>A0A6P8H448_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ELMO domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551129.1">
        <property type="nucleotide sequence ID" value="XM_031695269.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H448">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="GeneID" id="116288474"/>
    <dbReference type="KEGG" id="aten:116288474"/>
    <dbReference type="InParanoid" id="A0A6P8H448"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="136"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551129.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="37760" checksum="C29EA7A4A9CD7BAA" modified="2020-12-02" version="1">MADSLDQMIMVEIWTYLSFFFWYRRISKWLLHYATGCCELQRICNKTQHGAARTKSIEESLRSSRTKALSELPDKLNVKIEEAVMLVMTKKKIDVGQEKMFYDAMRVCLNQICGYTELFKIVEENRQVKYSSDNESHEKKLMELWSNMMPNTKLEERITKQWGEIGFQGKDPMTDFRGMGILGLDNLLYFASKHTPAARKVLSSSHHPHYGYSYAIVGINITGMAYRLLKTGALRTHFYNCKQGKPTMDDFNEVFCYLLFEFXSFWFNEKPESVMEFNRIRDKFEEKVTKMLSADINIQLTLKYRDISDLASLSSVTSLDTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H614</accession>
    <name>A0A6P8H614_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289067</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551819.1">
        <property type="nucleotide sequence ID" value="XM_031695959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289067"/>
    <dbReference type="KEGG" id="aten:116289067"/>
    <dbReference type="InParanoid" id="A0A6P8H614"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551819.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51924" checksum="FBDA32BC31A64943" modified="2020-12-02" version="1">MVDNHRIKVLNSGETTRLERVTERIDKERQNLAKELRDIQNARLLFEAKKRSKKELKRTLSVPVVRRQSLENLQNSVGMDIWTNNSHQRSXSRLFSNSAQSTPHSDLIRSKSEEAPIQQQARRMSLTNTPHRWSLSNQAPNQESLDCVPSNQRMRRISLPTVTPQLTCRTSSKWSKKDVLDDTSSRHMSESLSNLLPSKWSLSGSEKDIKMPPRRSRDKQPRSPQSDGRNKNWNLREDYTEVNSRGTFRCPLGEEKNDFGSNDLSVVFVDEYDRGQKQSSKETKLTLPLIVSSRSPSPLSQPDIHGRLSGTDMFKERRKRSLSGQILIPQINQVDLRRDHGSRDEYGSSGKQETGVRVSKPAERRASIKRVKALASVEIERLTRSSDELDEAMMSRFKRIGVSGMGHMVLKSAKVEEHMGTPGLLNTYGTKGTTVASSPLNDLAVTDLSDAPTDQDGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6P7</accession>
    <name>A0A6P8H6P7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase HACE1</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">HECT-type E3 ubiquitin transferase HACE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20 21" type="primary">LOC116288385</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19 20 21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus</location>
            <location evidence="10">Golgi stack membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031551028.1">
        <property type="nucleotide sequence ID" value="XM_031695168.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551029.1">
        <property type="nucleotide sequence ID" value="XM_031695169.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551030.1">
        <property type="nucleotide sequence ID" value="XM_031695170.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116288385"/>
    <dbReference type="OrthoDB" id="5981795at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="646"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="759"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="17">
        <location>
            <begin position="934"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="17">
        <location>
            <begin position="1175"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="131"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1078"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1094"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="1414"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="19">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031551028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031551029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031551030.1"/>
        </source>
    </evidence>
    <sequence length="1447" mass="162983" checksum="C94309885986E982" modified="2020-12-02" version="1">MNDSEGDTIPRAKKRRTKKLKSSSEESDSNNYVXPVFRKSRVSKNTKCDSSDDEETPRKNVKTPXTRSSERLKVKNSREFRLPSRDEVLDEVSPGNIICPRSSERKIKELKPRRLVNNFIRECNSYAAERAGDIYSTDSSLSDFINDSDEAEGEEDSENSSSXASSSSSSSKDVSNXKKKSPKRRKKNISSDSDSDEINSKRKRGKSKSKTIRMKKLDGKTNRKNAKEKSQNAKTKTSKVSRRKKKIVSDESESGCSSDGADDNVPLSTFLEKTPKTRKKKKILPNSSESEVEVDAMQVDAIQDGDSSNEEGERSFTKLKESRPSSTRRSTRRMKLIQKQQECHEKKYGDFLKRRDVAKLGTKDPKMKDDTSNQVIKEKLNNSDEGLQTLKELIENCXESDEDDKDFVVSDGEVSEEEMISDQELDVKFLKFINDHSQTEDNDSETLNSPTSGFSVQTKRKGRKLKNSSSKWRRINTRVESDDSSESETTIKDDCDHNCQLHTAVNHNDIDAVKKLLQQDPSAIYNVGYRKRSVLHLAALNGNPEMVQLLIKMKAKCEVLDKYDFPPIAYAANGHSECLKIFLRHTDIKRINNELIQTPSKMSLLHFAVGETRMGTECTERGKCLELLFANDKNLCKRMLQHRDVRRRTPLHAAVFASQHQCVAVLLKHGADPLSFRTKEGGNLLHFAVECASHLKQDSSEDKDTSLCLRQLVEPMALYLNETDENGFTPLMSACANGNDDCALALIQAGAXVMTKDSYGTSPLHLAAXAGSTECVNLLLRYGHQVDCVDDCGWPPLLYANFKAQEECVLALMKPKPDQLFVLGHLLKKQIKEEEKRKTMKVVKNVLFSLANHDAYYTVFNDFIRANPLLLDECDHGLLQHTWRGILDFDNKHKWFKRRLNLLRNDSYSICGPSLSVKRDDILGSTMQKIGHRHGKELRRSMSVIFEDEPGICTGPKREFFVCLCKDVVDPKRGLFEMSDDSQFSPTPNAYFASYVSKQPTTLFHSQNRDQDDTKVSEKKEEDVIQNIDIECTDSVLLAADCLENNSNEALNANEQYECTDSELVTAMETSVMDSGICSTADSQTQPDSRDADSASSTASLSTGGSTITXGTLPTAEENTNTGNPEEEERTSSANPSYSQEGDDASKRQTDNNTWISCLGKSPKDIVIPSIALRSKLKQLRLIGRLVGAAICQDMLLNLNLSKHFVKQVLGIPLSHPDDLSSFDYQLHENMVTWVQENSVDNLDLPFGVDVKNPWTNXLVSVNFSDDEDKTVDDSNKQDYVKLVSQYKLQTFIEKEVEEFNIGLHEVIPRELLSLFTADEFSLLMNGVTKIDVKDWKENTQYKGFRSNDPIITWFWDIVSRLKEEEKALLLKFSTGSPSVPIGGFANLQGLSGPNKFTITHLFGSNKIPQASTCFNMLNLTDYDSEKQLREKLLIAIRHGSEGFSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7P3</accession>
    <name>A0A6P8H7P3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288797</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551501.1">
        <property type="nucleotide sequence ID" value="XM_031695641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288797"/>
    <dbReference type="KEGG" id="aten:116288797"/>
    <dbReference type="InParanoid" id="A0A6P8H7P3"/>
    <dbReference type="OrthoDB" id="10335304at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551501.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18779" checksum="EE4730DBCCCEAE3D" modified="2020-12-02" version="1">MHTEIPKKKLLELMKVSMDAQYANTQLNIFTSFIAGKVKEFLKXGKWQGEGGLRVSAGTTLKQAQENCLLAQSILNSDEIVFGCYRVKGHGVVTLNRKHGKAFIGNKLSHMRKPSAYKGKETGQSVRSCARKENTSKEKVKKANKEQSCNTKKTEKVSFXRLYHHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8D6</accession>
    <name>A0A6P8H8D6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing G-protein coupled receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549007.1">
        <property type="nucleotide sequence ID" value="XM_031693147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8D6"/>
    <dbReference type="GeneID" id="116286591"/>
    <dbReference type="KEGG" id="aten:116286591"/>
    <dbReference type="InParanoid" id="A0A6P8H8D6"/>
    <dbReference type="OrthoDB" id="27267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549007.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24888" checksum="F131CA4AAE1E16CF" modified="2020-12-02" version="1">MTKLFSLHLDGNKIKILKKGAFEGLRSVKELHVGNNLIHNADFYSLNGLQSVSLITMQNNSLTTLPYLGNLTQVTTVRFSFNMFDLENQTAVFTNLGELVILSMHEAKLRRIPDLSQNPNLLYLFVSKNRIKYIKDGAFLFNSKLEQLMMNSNNIEILTNESFTGATSLETINLSDNPLKQIAHSTFFHESLKTVFLIDTMLKHPLLISTVSHPIISFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9H8</accession>
    <name>A0A6P8H9H8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116290254 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553119.1">
        <property type="nucleotide sequence ID" value="XM_031697259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9H8"/>
    <dbReference type="FunCoup" id="A0A6P8H9H8">
        <property type="interactions" value="2660"/>
    </dbReference>
    <dbReference type="GeneID" id="116290254"/>
    <dbReference type="KEGG" id="aten:116290254"/>
    <dbReference type="InParanoid" id="A0A6P8H9H8"/>
    <dbReference type="OrthoDB" id="6367910at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46253:SF1">
        <property type="entry name" value="TAB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46253">
        <property type="entry name" value="TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CUE" evidence="8">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553119.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41132" checksum="239B740BF16DBEA1" modified="2020-12-02" version="1">MSKVCMAAVNDNDRTYTLSRLQERFPEIPEGVISKILAQYANNMEKCLTILSQESDKYLYGESMDSPGSKNSNSIMEPLRINIPSNDTDLSREMDSFAILPQTTKTVAVPSSSGTTIFSNLSRERHHSVDDYNDYNRKVIQHQKQRLDRLRLEYEAEKIKLSRLHKFVKDKEEELINKKYRVASNPSKTHVDHLLEETQVLRTEIDNMTQVIDNINNGASLLGFVTTSQSNAENISSTPHQHPVPPPVQKSASFPRTTGQYFGPGVWKYKSHPPVEGVHTPRPPWLPPMGERPKTQSPVHDPSMDEWILLPKELISAPIPTTTIEPTPPPPPEDTEQTWQCKHCTLENHGALNSCEACERSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9Q6</accession>
    <name>A0A6P8H9Q6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116286782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031549220.1">
        <property type="nucleotide sequence ID" value="XM_031693360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9Q6"/>
    <dbReference type="GeneID" id="116286782"/>
    <dbReference type="KEGG" id="aten:116286782"/>
    <dbReference type="InParanoid" id="A0A6P8H9Q6"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038060">
        <property type="term" value="P:nitric oxide-cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000015">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF10">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE 88E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="242"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031549220.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64600" checksum="A87E8BDCCFA738F1" modified="2020-12-02" version="1">MDVFYEVFPFHIVYDHSMTITSVGSSLDAILPDLVGKKIAQEFSLIRPFLEFSWENIAYHTNVVFELQSRQSSINIRLLKQNGVKRNHSSFGCPVANGGPVENSVPVENWITSTKEEMQGRIHLKGQMMHIEEWKSMAYLATPVIQNLDVMCRIGLFINDLSMHDSSRDLVLAGTQQSAELKLALDQEVQKSAKLEESMRQLDIEKLRTDTLLYQMIPKTVADRLRKGEPALNTCETFSEVTILFSDVVGFTTICSLISPMEVVTMLNCMYTTFDKLSEKHNVYKVETIGDAYMVVSGVPERTKYHAEHIADMALNVLTAMPNIKDPAQLTEHLQVRIGVHTGTVVAGVVGLKMPRYCLFGDTVNTASRMESTGLQNAIHVSESTEKRLSNENYILKHRGSMDIKGKGGMKTYWLIGKNEDPPQDLDSIGDAISLISDNDFIGGAESTMSDTSVNVFFGDHSYDTRMTISQADLPIHDHICAPDSEGEPVAYYGHCPHNAKKEEKLRDKWDELENSTKEDSLKNTDKSSKKSSKKKAKSLTKEKNENDEKAIEDIKKAENGAKQEGKGLVSTSLCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAK5</accession>
    <name>A0A6P8HAK5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal growth regulator 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549525.1">
        <property type="nucleotide sequence ID" value="XM_031693665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAK5"/>
    <dbReference type="FunCoup" id="A0A6P8HAK5">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="GeneID" id="116287051"/>
    <dbReference type="KEGG" id="aten:116287051"/>
    <dbReference type="InParanoid" id="A0A6P8HAK5"/>
    <dbReference type="OrthoDB" id="5979279at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028087773" evidence="6">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031549525.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20742" checksum="151D3A684E6E86E0" modified="2020-12-02" version="1">MFIFSVFLFLALPRINYLTSNLSGNQGDSITLRCNASGYPAPRVTWIHKDTNRTIANSSATSFNITCKASRGKYCCHVSNDFGEETICTSLEVTEYQPINTKLTLDMNFATANKTFEVFCNADASPPANYSIKQGNITMLNSSDGNVTITTPNNVTYLTIGCIAKNKYGQGKEIYLKMPIYRKLNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBR2</accession>
    <name>A0A6P8HBR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-1 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116289764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552568.1">
        <property type="nucleotide sequence ID" value="XM_031696708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBR2"/>
    <dbReference type="FunCoup" id="A0A6P8HBR2">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="GeneID" id="116289764"/>
    <dbReference type="KEGG" id="aten:116289764"/>
    <dbReference type="InParanoid" id="A0A6P8HBR2"/>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552568.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35726" checksum="8B63DF0799F0C20A" modified="2020-12-02" version="1">MDRSFENCPRIAQVFIEKVTRNRPEWVDAGNIINIFVNAILAVTATLGNGMIIVAILRSQNLQTPSYLLITTLAFADLLFGLMIHPLHIVGGTFFLQGNIRGLCAMASLYIFFGLFLGSVSVMIVTCISIDRYLALTLRHRYTIIVTKKRVRYMIVFVCVLAFLGAFPNIFEKYFDIFSRAMFSCYMALLLITCVFYIKSFRALHLYTVQVHAQQPNPLAINFDVVRYKKTLKTMLLVLACLLICYVPSICAFSMWKMLDNRKGELVVYFTTITLICLNSSINPIIYLIRFADIRNAISKAYQTGRDIFLDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC92</accession>
    <name>A0A6P8HC92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase SMG1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116291071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554049.1">
        <property type="nucleotide sequence ID" value="XM_031698189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC92"/>
    <dbReference type="GeneID" id="116291071"/>
    <dbReference type="KEGG" id="aten:116291071"/>
    <dbReference type="InParanoid" id="A0A6P8HC92"/>
    <dbReference type="OrthoDB" id="10065496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554049.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24442" checksum="A9CBA9943BB63618" modified="2020-12-02" version="1">MENTAKVAGDRLSDLTSREGDWFLEELCSMSGNVTQLLSLLRGHPLVIEEQKSSSKEELNNSIKGIFAVHKVFSALQELMTNFRNIIVPEAIKSFTSGDPSVTRMLESLERLVHGEDIAALAKTLEREMNSSHECQDVNSSSISSKISILQQQFDAIQQSRNAIGKKSSEQMSAGQMLLAGFNGLFTKVESELDLMNAILAQVNSSFGNKTCDVVQEAKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCG9</accession>
    <name>A0A6P8HCG9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553336.1">
        <property type="nucleotide sequence ID" value="XM_031697476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCG9"/>
    <dbReference type="FunCoup" id="A0A6P8HCG9">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="GeneID" id="116290447"/>
    <dbReference type="KEGG" id="aten:116290447"/>
    <dbReference type="InParanoid" id="A0A6P8HCG9"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF84">
        <property type="entry name" value="LD05335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="81"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553336.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45037" checksum="438F2BD498922B29" modified="2020-12-02" version="1">MDELPTTEFRGPIFPANNCTGGICDGSVCLCGNSYYDESDAGENAPLISYESATQNDTYFTDVHCHEFKPIFSNKTARRKLTIASIVCLFFVIAEVIGGYLAHSLAIMTDAAHMLSDFAAFLISLFAIWVAKWQPDKKRTFGYYRAEVLGALVSVLIIWVLTGILVYLAVQRVLTQDFEIDADIMIITAGIALAINILLGIILHQAGVPHGHSHGGGGSHGHSHSFNGSVNHSHSNSMAQRTRSNSVYEKENINVRAAFIHVLGDVVQSVGVLIAAYIIKYKPSWKIADPICTFLFSILVLITTLNILRDTIHVLMEGTPKNINYNAVKGGLENIQGVVAAHSLHIWSLTVNKAALAVHLAVAPGTDTQKVLNIAHQKLKTDFQIFHSTIQVELYQESVMTNCNECQDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE62</accession>
    <name>A0A6P8HE62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Trace amine-associated receptor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116288222</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550850.1">
        <property type="nucleotide sequence ID" value="XM_031694990.1"/>
    </dbReference>
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        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="GeneID" id="116288222"/>
    <dbReference type="KEGG" id="aten:116288222"/>
    <dbReference type="InParanoid" id="A0A6P8HE62"/>
    <dbReference type="OrthoDB" id="1741314at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028289554" evidence="12">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="332"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="500"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="285"/>
            <end position="533"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550850.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63411" checksum="A0AC35C6A5D72378" modified="2020-12-02" version="1">MMLHIVMLAFYGINSCDATTNKNTACEAHLNTSWDGNSTCAHSRDSECNVHVTCGLKTITQLVNLISSPEAVSRLDISKNSLVEIKEHMFLEYKNLVALDLSYNSIQVIQRKAFNGLMKLKTLDLSFNLLHEWDTLDITKQLPSLTELNITGNPFWSPGQHIRDLPNISYISGIVTYALPYENKNCVLCELQKHADMKNRISKVNLVTVDGLHCFELLIDFGANFSAVWHSNFSITCAYRYDLCKSPPFTKPPSNISVEFIDGCFLGIRTWGLPNIPIGIATMMVNFVVMATVALTPSLFKKANMVLMASMGLGDFLQGLWLLILTIVRISMSSLEFFDKKMPYLCYSLFALLVTAQSLSAFVSFIVTIERYLCIVYSTKPNVRITRKIAIALLVLVGLLILGVNVTPVALQMTSPFTDYSCLNLHVPNKPFFLESIAYVSVISYVVSYILYARIFWTVRRSSLNVGIQREGKLAKRIITVITTNLLFLLGPMIAGQLLVTLYDLRWKTKIICWNAVLLWFLGINSFFNPLLYAFRFERFRRSLKLLMKGRPNEVGVVPSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE70</accession>
    <name>A0A6P8HE70_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRPL translocation defect protein 14-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031554006.1">
        <property type="nucleotide sequence ID" value="XM_031698146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HE70"/>
    <dbReference type="GeneID" id="116291025"/>
    <dbReference type="KEGG" id="aten:116291025"/>
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    <dbReference type="OrthoDB" id="6375174at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein, isoform C"/>
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    </dbReference>
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        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
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        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_28"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554006.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44887" checksum="2BFFB0549F962FD3" modified="2020-12-02" version="1">MNGATKEPAKERRVYKVVLTGGPCGGKTTTQARMSTFFEDIGWKVFKVPETATLLLSGGVKFAELDEESASNFQENLLKTMLQLEKTYFDLAQRCKIDCIIICDRGAMDPSAYIEAKEWKKLMDANQWNTIQLRDERYDQIIHLLSSACGAEAFYSKANNLARSEGLELARDLDTKTQQAWVGHPYFDVIDNTIEFDAKVLKAIRAVCTKIGIEVGDRFAPNSIKRKFLVKCLPDEKLFPPFQDFDVVHDYLTVTDLEIGTQARLRRRGQNGRYTYMHTTRRPKIDDQVVEVRRSLDRRDYELLLAQRDENRQSVYKKRRCFLWKNQYYQLDVYREPYHARCKGLILLETYTTKSTENLELPSFLEIEKEVTKDPDFSMYHLSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF05</accession>
    <name>A0A6P8HF05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation channel sperm-associated protein subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554331.1">
        <property type="nucleotide sequence ID" value="XM_031698471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HF05"/>
    <dbReference type="FunCoup" id="A0A6P8HF05">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="116291305"/>
    <dbReference type="KEGG" id="aten:116291305"/>
    <dbReference type="InParanoid" id="A0A6P8HF05"/>
    <dbReference type="OrthoDB" id="2159869at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028748">
        <property type="entry name" value="CATSPERB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048788">
        <property type="entry name" value="CATSPERB_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048789">
        <property type="entry name" value="CATSPERB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053903">
        <property type="entry name" value="CATSPERB_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048786">
        <property type="entry name" value="CATSPERB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14705:SF0">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14705">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21541">
        <property type="entry name" value="CATSPERB_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21548">
        <property type="entry name" value="CATSPERB_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15149">
        <property type="entry name" value="CATSPERB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22830">
        <property type="entry name" value="CATSPERB_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027768688" evidence="2">
        <location>
            <begin position="33"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Cation channel sperm-associated auxiliary subunit beta N-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cation channel sperm-associated auxiliary subunit beta 2nd" evidence="5">
        <location>
            <begin position="197"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERB head" evidence="6">
        <location>
            <begin position="594"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Cation channel sperm-associated protein subunit beta C-terminal" evidence="3">
        <location>
            <begin position="846"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554331.1"/>
        </source>
    </evidence>
    <sequence length="1098" mass="124949" checksum="7E6A4751FA3303DA" modified="2020-12-02" version="1">MPRTLSFLSVFLCVRALFVCLAVLSTFQCSFSSFLPYDFGHEDVESVVYTSNSEDNGTDSFGQLYFQGSSMVIIYQVRYRYNDTKYNRNSLVRRYASQGIKPNIRFWNLTWNTSFELKELVEEDTVYWRRNISKLQISQDTNYISGSWKYLVELGKGLNLFEKSGSLILKDEEPLLNLEFGDEITNPILFQSKPNGLIIKSSPCSSGVAAIVPVINTTEDEYSGCYFGVTYNYFNPSSVSWHNLLHQSSAIPNEYSICKQSSFSKCANLSIIDFTLLKNHLLFLTTNGILLSKNFTKALRNGPGTKLSFTSVQSIHPDIDEAIRMGSVNRREDMKLFHTPHCHRSYVSDLEEVCIVYRNNTSNSSLTVCSYAPFERWRTLVLESAPEKHYLLDMVQDIDRQSTVALINDKSQEVTLLQVYNGTKLSFPAFIFDKGETAESLYFHAYTKIIYAYGSQVWQSLDGGNSFYKVTSLHDQDRVTSFSIDLFGNTFCVTTRLGSILIGKAGIHRAIVVERLGNGSLSHPVYTQVLGHANTVVALKPQVAGGNFSLSPTAFEIKRDNESQHTLPLSLLASFRDETQVEFYVSSECGDCFSSGQVIYSKYGGSARIVRVEKTSILMSNVFKHKIVGLVTKAFAEPPRNRTNSLLQVRWSGWNASLTLLSRMNTDDRWQEDDLGKTVILPEGQSFILKHYVNETTFIGLTYIPWMRNTPWEDTFEGWTLHDFRDPISSNISWWVNEDTCRSVLLERRNLDMRLFHLDSMDSLTFTATSISKTTSRQPFARVFISNPRLFILKSVVHTSFLNTSLTALISQKPSARGTSSLTVLLQHSSLFCKSTSFTISIHSGCPPSKKLRYIYPSTFSDASFLDAKAIDSKGIQRNFKLPFNYRPPSARGKAIPLTGNIYNVDPKRPHYKDAYSVTRETVQYKQCQGVNERTACGCTLGMRRSSSERYSDCIDTVYRILFTEKLMPKFTVSRDERETIKLDSPYYLKELNNRIDYEALNPSTKTFPGIPYIIMEEKMNSSVEFVGSGLYHFRAHVVQDNYTFCELTDEFLVFVVDTPLPYPVKDIVMACTVMGFSSMLYLIYLVFFHGKKKIKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF60</accession>
    <name>A0A6P8HF60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555054.1">
        <property type="nucleotide sequence ID" value="XM_031699194.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HF60">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="GeneID" id="116291961"/>
    <dbReference type="KEGG" id="aten:116291961"/>
    <dbReference type="InParanoid" id="A0A6P8HF60"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555054.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41649" checksum="A76A9BD7C9C0BAE9" modified="2020-12-02" version="1">MNLTGGERANESSRANLSFQNXTESPSCSYYCEPLALEVFKLTLQVAIALVGVLGNILVCVVITRRANMKTSMNLYLRNLAITDLGVLLVNFPLVANSIHNTSGWPFGKFLCLYVAPATDIFFGASIWSITVIAIERYKNIISRKVFVKKVESSKRVTLKIVLIWLVSFAVVAAPLYPFFLYRSSSVSAQCYPDGPTFVLKAYAVSLAIFWYLLPLGIITVTYWKISAQLRQSNTFHKTMHGEEAAKSKLFKEEERRRLKQNKKAQRILTPLVVIFAVTMLPLNVFRLALGFFPQFVKYEYYYQLFSVCALFVVINSASDPIVYYISSKEFRKGLQDLLCNGNRLSKNGPRAKPFGKEASTSGPVLETEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG25</accession>
    <name>A0A6P8HG25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gamma-tubulin complex component 3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554776.1">
        <property type="nucleotide sequence ID" value="XM_031698916.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HG25">
        <property type="interactions" value="3056"/>
    </dbReference>
    <dbReference type="GeneID" id="116291705"/>
    <dbReference type="KEGG" id="aten:116291705"/>
    <dbReference type="InParanoid" id="A0A6P8HG25"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="259"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="570"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554776.1"/>
        </source>
    </evidence>
    <sequence length="923" mass="105314" checksum="E43A60D5A2DD8E4F" modified="2020-12-02" version="1">MVESGESDPNSPAGLLYALCCKIIGKDSKTQDPSVLEHYQYALRVVGSRFAPSVANDEFRIAERIKRKLVRENKEVDAAIFSELYRKLGSQGVIQNKWAILYFLLNISDNRKSGTSQGQNADVFFGLGLPLTSTSTPATNALRPVLNTGGYSTVHSQSSSGISSDPSSRTFSSDTQTPSISVQRLPNTGTQSVRFADNVHTYRSEPSHLSSMVAKSLTLSRQQEFDSVGRIPGPEAVARLQXYGTGENTSFEASEAILLREIIYVFQGIEGKIIKLDEATDAYRIDPKVGVPKSVRDLVNKLAELGWLYRKVRKYLDARTGDRALGLVGQSFCAALQQELTEYYRLMAVLEGQQQLSDQGIEGEGASGSLTLRRLMVWTFDPLIRLRTLATLVDTCKGKKGGALLSALHTYMQHGDPFVKSLVKHILNLVAHPIRNIMDRWIYDGELEDQYQEFFVAVDYTVGDDRLWYDKYSIRKPMLPSFIPLELATKILNIGKSINFIRHVCKDXGSIIRDEDKVHERTKAEKNAAAAQLTADAEFTGAALQETIDIAYRDTSKKLLEILFTKYQFQDHLKALRLYMLLGQGDFIRHLMDLLESDLDKPASTLYMHNLTGVLEAAIRATNAQYENPEILKRLDCRLLEVSPGDTGWDVFSLDYHVDGPISTVFTPECMIHYLRIFNFLWRAKRMEYCLTGIWRNQMVSNRLVNTIPELVPVLHQCHMLGIEMVHFIHQMQYYIAFEVLECCWADLKKQVSEASDLDHIIAAHETFLDHVISRSLLDTESRNMLTQLRAIFDLIVQFQNAQSFLYTAAEEEVQSRQKLKESVNRKTEKGDWGMTEEDEEEVRRKSVHFVDKIVPDIRAQLRVLFQSYQDMVQQFLMMLTSHQDDNLRFLSFRLDFNEHYKKKEPKLRSPLTHRFSKRYKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH87</accession>
    <name>A0A6P8HH87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC116292103 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116292103</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555210.1">
        <property type="nucleotide sequence ID" value="XM_031699350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031555211.1">
        <property type="nucleotide sequence ID" value="XM_031699351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HH87"/>
    <dbReference type="GeneID" id="116292103"/>
    <dbReference type="KEGG" id="aten:116292103"/>
    <dbReference type="OrthoDB" id="5983955at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555211.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="63768" checksum="C0DE394F68B73840" modified="2020-12-02" version="1">MSSNKNKEDKNIVLKQLLRDLRSDFTKVCDLFERIIDFNQSPTSESAKRKLDLEIDRIKALSEQCVSDASNLKEFDVEETQAEGQKDIPEYDKVYVKQVNGIVTSINTLKKQLVNYLQEKSEAEENISKENFKLRLDLQKEQAESMHQRQNHDYAVTEKNTVLATCRKLEEQLEERSRQIQQLQREGTVSLWQREKAKLVKDINSNEEQLTKELKEVKEQHEEIKTRLNRRIQDLSEQVKFLKMERDVKNGAVRLHGKAGNASQSELEKMKQQLFMKDRYLLVAEGELQKQQKYYVGFLSGISRDFRIMLERQHLTVKDYNKDQKAFASMLNKMYVAVKEGRLSDFRATLPSHYLGINVELSGHPLGKKLSRPFMDLEKHLEEVENTDLRIDVNHPLLYGWREGKGDSAEGRRGSKSAQVSGVHPQLVDMKQCKPLTKETLEHFPEWSENQIEEMFAQFKSFDANGDFHLDTQELLRAIPDTLGRMATTEEIKEAMMEVDIDSSGTVDFYEFLCVARLISQGKGRIVIYSNSRPMVKKGLDSALFSDRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHB8</accession>
    <name>A0A6P8HHB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116289224 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116289224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031551970.1">
        <property type="nucleotide sequence ID" value="XM_031696110.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289224"/>
    <dbReference type="KEGG" id="aten:116289224"/>
    <dbReference type="InParanoid" id="A0A6P8HHB8"/>
    <dbReference type="OrthoDB" id="5969175at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551970.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="60758" checksum="AB6CC3A529384192" modified="2020-12-02" version="1">MPYHCAVKGCAHNSSRQKGNCKFFRFPKVIENQGNQCKTISEDRRREWIANIYRGDLKSINLENTRICGCHFISGEPGKLYDRLNPDWAPTQNMGHDRISSQKVAASVQKYERASQRASKKRKAEEMQKSETQEKPPSLDVQTSPSSSIEXPHLSDFNSYHESQDETENTQVAFENEWNXDCSCQTDSVTVANFSCQTDITMADLSCNDIYINTVXLELQNLKQQLSSLQLSEDSLRGNDEKTKFYTGLPNFLILMHIFHLVAQKVSTTCNNALNQFQEFLLVLMRIKLNLPFQDLAYRFGISQSTATRIFYRWINIMSDRLDFLIKWPEREQLRKTMPLVFQQNFGKKVAVIIDCFEVFIDRPSSLIARAMTWSNYKHHNTVKFLIGITPQGVISFISKAWGGRVSDKYLTENSKMLRKLQPGDIVLADRXFDIEDSVGFYQARLHIPAFTRGKKQLSALEVEQTRKIANVRIHVERVIGLVRRKFVILQSTLPVEAITAKPGDSLAPIDKIVKVCCALTNLSDSIIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI00</accession>
    <name>A0A6P8HI00_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRELI domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556009.1">
        <property type="nucleotide sequence ID" value="XM_031700149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HI00"/>
    <dbReference type="FunCoup" id="A0A6P8HI00">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="GeneID" id="116292798"/>
    <dbReference type="KEGG" id="aten:116292798"/>
    <dbReference type="InParanoid" id="A0A6P8HI00"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556009.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20634" checksum="4CB56B996930D81B" modified="2020-12-02" version="1">MRCLEFHYLFKYSFETVVHAYFQKYTSGKDKNVTSVIVLEHTLDQNTGDEYIVRRGKCVNVLPSIFNKFLPFPAIEVEEKAWLSRKEKVLQLHSYNITASDYVKVEEYSTYFPSESNEKWTVMKQKGVITAFGLGPVFGKMLEAFAVRFFHHGANKGFNIMEDLLMTMHTTSNCVTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIX9</accession>
    <name>A0A6P8HIX9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293083</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556339.1">
        <property type="nucleotide sequence ID" value="XM_031700479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIX9"/>
    <dbReference type="GeneID" id="116293083"/>
    <dbReference type="KEGG" id="aten:116293083"/>
    <dbReference type="InParanoid" id="A0A6P8HIX9"/>
    <dbReference type="OrthoDB" id="10301584at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556339.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24989" checksum="B787FF795A6F76C7" modified="2020-12-02" version="1">MPGQIFRTCCCCDLRTGVILIALFSMGIAAINIYTGVGAVLELKHLQPKIDHEEKDQLPIPWKYYDDTINLGWSNIAFFASDLIISVVLLIGALQRHKCLLTTWMVWTLVGLAYHLSVSIFFLSIWKGVPTFGYTMIIDLIIAVYFLLVVYSFKQEIINQERNPRIPLVMTAGQPIQGFSYPPTGVNPYQQAPPPYMYPASNPPPYAQCAPAGAPPANEQKVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL99</accession>
    <name>A0A6P8HL99_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="5">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116292511</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031555713.1">
        <property type="nucleotide sequence ID" value="XM_031699853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HL99"/>
    <dbReference type="FunCoup" id="A0A6P8HL99">
        <property type="interactions" value="1665"/>
    </dbReference>
    <dbReference type="GeneID" id="116292511"/>
    <dbReference type="KEGG" id="aten:116292511"/>
    <dbReference type="InParanoid" id="A0A6P8HL99"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031555713.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43207" checksum="DF315FFFA2E4126F" modified="2020-12-02" version="1">MYPLRLFNRVNIVSCRVATLAQHLRMSSSSASSTKSIEDVFMEIKDQAGIITLNRPKALNALNLSMVRKIYPVLKSWEADPKVNLVIIKATGDKAFCAGGDVRAIAEDGLRGGNLPKDFFKEEYMLNYAIGTLQTPYVALIHGITMGGGVGLSVHGHFRVATEKTLFAMPETAIGLFPDVGGGHALPRLEGNLGIYLALTGFRLRGYDVKHAGIATHFVKAEKLSELESSLLGLSDCRLQTVRGLLDDFDKECSKDQNPNFTLQEHMDKINSCFDKNTVEDIMSSLEKNGSEWANKQIETINKMSPSSCKVTLRQLREGARMNLADCLQMEYRISQRFMENEDFYEGIRAVLVDKDNSPRWKPSTLQGVSNEKVDSYFLPLGERDLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLH4</accession>
    <name>A0A6P8HLH4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tumor necrosis factor receptor superfamily member 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557249.1">
        <property type="nucleotide sequence ID" value="XM_031701389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLH4"/>
    <dbReference type="FunCoup" id="A0A6P8HLH4">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="GeneID" id="116293892"/>
    <dbReference type="KEGG" id="aten:116293892"/>
    <dbReference type="InParanoid" id="A0A6P8HLH4"/>
    <dbReference type="OrthoDB" id="10061577at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005035">
        <property type="term" value="F:death receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048406">
        <property type="term" value="F:nerve growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052302">
        <property type="entry name" value="Neurotrophin_rcpt-DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46605:SF2">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46605">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027641145" evidence="8">
        <location>
            <begin position="23"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="6">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="10">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="6">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="10">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="9">
        <location>
            <begin position="265"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557249.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38163" checksum="17AD3A08CA0B0A47" modified="2020-12-02" version="1">MWKRMVFLGLLFILLPIYHVLSDCPIGTYPSYHINVCERCLPECRSGQIMIAKCNQTNKFICQCPSNKYWDGNLALCQLCKSCGTTEIVSQNCTHVHNRKCSNCPLGTFVKSPYQCEKCSHCEEGEVVARKCNGSKDTLCSRPFSRKPLFIGDSNKPAFTLTQPEPSDDPEKVEKNNTTVVILSIMVALFVVALLLVCLCWHCSSNIQRRNKYPESSFTDDSEIDDFVKKRPLPPVRETGLMLRDLNPETFENLCCLLNPEGSRNWKVLAGKLGYSQCKIQNFKLNRNEACQSLLQEWGTEGNTTVYVLYNHLLAMQRDDCTELLQKYLVQENQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMF6</accession>
    <name>A0A6P8HMF6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031556896.1">
        <property type="nucleotide sequence ID" value="XM_031701036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMF6"/>
    <dbReference type="GeneID" id="116293591"/>
    <dbReference type="KEGG" id="aten:116293591"/>
    <dbReference type="InParanoid" id="A0A6P8HMF6"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="8">
        <location>
            <begin position="98"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="7">
        <location>
            <begin position="580"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556896.1"/>
        </source>
    </evidence>
    <sequence length="742" mass="85221" checksum="37F0127EFBFF3F74" modified="2020-12-02" version="1">MERMVNGGSGVRQENQRWSLIHGPRFLAVLLVISMIRVASTQDEMRSNLDQGLNKIRTPRYAKTTRKTNTQSNRVCNTTECIEAAIQINSSINLAVDPCDDFYEYACGKWPTNNPIPTGYAYHSIYTIAELKTQTYKKTKLESGVIKVKGASKEVQQMPSVLYASCMNLTAIENLDDEPLRERIREFGGWDMIGDWDENTWDFNKTLISIHKENGAGPFFKVGIIEAGKNKALNIHQSEPPLGKKYFLNLSSKQVVAYRQLIIDILVLLGGNESTTAKKADEIIRLDAQLANLTLIEAEWRPFETKTKTLEQLQQQVPEFNWTVYLNKLFEPSAIPQSEPIALPMLSYLKNAMKIIQNTPKRILANYMVWYVIQYENWWLAKPFRDALGRYTQAITGATSDRERWKTCIDSAFRAFSDLITAAYVQEHQAELAKRISLAKQIVSEEVQAFKDNINSLTWIDGATKSALYQKADCMGQKIGFPSYMLNSTKMASLFEKYRGLNITAATYYKNKVSFYKNKRQRVLRYLRKPRDNTLWYASPLTGTAIYNLIENEITLPAAILQPPILYPSKFLRSRIWFIGRRYDKDGKERSWWSNSTLEEFDIRLKCFEKQYSAYKVLGKWPINGKNTAEENVADNGALKIALKVYYNWVSQNPGEKWLLPGLNYTNEQLFYIGFAQHFCSNSTLQDRYDMIQSGSHTDDKFRIIGSLANSCEFANAFKCKKYSPMNPINKCYLWSKEGPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMI6</accession>
    <name>A0A6P8HMI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dystrobrevin beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031553860.1">
        <property type="nucleotide sequence ID" value="XM_031698000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMI6"/>
    <dbReference type="FunCoup" id="A0A6P8HMI6">
        <property type="interactions" value="1386"/>
    </dbReference>
    <dbReference type="GeneID" id="116290881"/>
    <dbReference type="KEGG" id="aten:116290881"/>
    <dbReference type="InParanoid" id="A0A6P8HMI6"/>
    <dbReference type="OrthoDB" id="6019271at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16244">
        <property type="entry name" value="EFh_DTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="437"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553860.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60475" checksum="0073B04AA823B643" modified="2020-12-02" version="1">MSVSFEGTASHMLAGNILNESIPKDEAEHLLQELIIDMSNENFDTIKFAAYRTAAKLQFVQRRTNLHLVDVYNMIEAFRENGLNTLDHNTELHELRVEAVVSSIFYALNKRLPTSHEVDVEKSISLVTNWLLYAYDSDGIGRIRVLSVKTALSTLCYGRLVDKLRYHFSQIEDDNGILNFPKFEAYLRELLQLPSAVGEGPTFGFAEDVASSFFKPQGPLARQGTTLQNFLECVISKDTPAPYAWLSTLQKMNNSASVEHQVGCQICKKKPIVGFRYKCLHCQNYILCQDCFWRGKTSQAHKTDHDVREYTTWKMGERGNSIRSKFLCGSGKKKRPSLPEYPHEPQPNKTLDMSNIVPPLPSDLSGQAHATSDYTSSPSPESGASSTSSNRRKLSEDFDQRMDDEHKLISRYAARLAANSRQKPPSKSSSELSIDSNREQRELIQTLENKNRLLLKEIRRLRDEHDEASKSAAQIAQNPELLAELKLLRQRKDELEMRMSALQESRRELMVQLEGLMNLLKPGTGGAGAEESITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMT7</accession>
    <name>A0A6P8HMT7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116290987</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553965.1">
        <property type="nucleotide sequence ID" value="XM_031698105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMT7"/>
    <dbReference type="GeneID" id="116290987"/>
    <dbReference type="KEGG" id="aten:116290987"/>
    <dbReference type="InParanoid" id="A0A6P8HMT7"/>
    <dbReference type="OrthoDB" id="5979519at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="Sigma3 and sigma4 domains of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028036940" evidence="3">
        <location>
            <begin position="25"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031553965.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="56105" checksum="F7FC954CDAB81319" modified="2020-12-02" version="1">MGQLTGRSAVLLCFMILHHDFIIARNHIPYSGDKELEKDVVYDSLGPVYIGHDVAAFYDDVNSELKDDNLYSRTLSSSNNSNLTKSLQKTEGGRRRNFSRNYVVTQVVFNLQCHLKNARQVTAIVQKVEFVLTFDKDALRCTVQTLLQLVSQQISSTLTTANAKQILQAAPKAKALLGFTDDAIKASVRSSSILKVVSRSSGTVRALKFFKGAGVVLSVIGIGVDIFSIVSTVLECRDRRDKAKESLNKLKEAEQEAIKAEKEVALYCDEVTTFWKENVIPAVCSESLKQALRGVKDLVQSAVSKNEELKKALEYIDQFTERIDKAGAAKTNTLLKNLFKGLASVEFTMSCYSNKFKLIGHVINGCKMGTATLDKLFDGGIKLFPANSEECQTRSGLVYTSNENISNIVKEAAKVQGFHTKCPLNNLDLKELVCMKKREGITVEEIAEESNISEADVKRIVEKCTQELTPKEKKVVCSLRASTDWTDEVIAKKLKLSVKEVKNVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMW7</accession>
    <name>A0A6P8HMW7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116291018</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116291018</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031553999.1">
        <property type="nucleotide sequence ID" value="XM_031698139.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554000.1">
        <property type="nucleotide sequence ID" value="XM_031698140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291018"/>
    <dbReference type="KEGG" id="aten:116291018"/>
    <dbReference type="OrthoDB" id="6131651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554000.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="60516" checksum="A0431024D2E1C4E0" modified="2020-12-02" version="1">MEVEKGEKEGKTEEAVRRPVKPQLKKHMSSTFIPMIGGYMSDDELKHHVDHQLSLEQKKYEPEEEPIAEEQEKKKKKVKFKKNKTISSDEEDEKDEKRREYREGLRDRMLEDLELLRDYYKRIYKRALKEKVSNQHREFKTRNKKAVEKERRLXEKEEKDRHKVVIRLPKSKVMNDRSYKEDIQETVYHKIIKLEHQLKKQGYLSKVFEIKAFWDFILCPGNLEEVMQKGKLSWEDILQYERTHRDTLMSSTEETQHKWTNSDINKMIADNARPSWHNSKHARSNVFTPSGLTDISSSQSGRGQSAPTSKQKSITNAQSNGALTFDQKFPKVEFPPLAAYRLVFGEQEPDPEEIERELEIQRKEEAKRDTRNKLLTMFSHALANRAATQRLIERNEEYSFNQLVDTSSVKELMYYENERKPKVQLTTKTLQAHDRLSSPPHAIKKKGGSKKISSKKMARTPSPESEFSGTEREMVLYREYKRLPPIAAPLSLHVLEQTNQVKEAKGLSTLWVNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP33</accession>
    <name>A0A6P8HP33_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E1 ubiquitin-activating enzyme</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031558139.1">
        <property type="nucleotide sequence ID" value="XM_031702279.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HP33">
        <property type="interactions" value="3033"/>
    </dbReference>
    <dbReference type="GeneID" id="116294644"/>
    <dbReference type="KEGG" id="aten:116294644"/>
    <dbReference type="InParanoid" id="A0A6P8HP33"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="925"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031558139.1"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119158" checksum="3D78740E4B59036F" modified="2020-12-02" version="1">MSSVEQDPSTISPPAKRPRTSDNLQLSNSTGNSLNSNSHSLEAIEMSDNHGEKMDIDEGLYSRQLYVLGHDAMKKMASSNVLISGLKGLGVEIAKNVVLGGVKSVTLHDDGNVEMTDLSSQFFFKPEDIGKNRAEACCSQIAELNSYVPISVQTQKLNEEFVKQFQVVVLTESSLDEQLWVSDFCHAKGIKIIIASTKGLFGQVFCDFGEAFTVVDTNGEQPGINMISSITKEEDGVVTCLDEKRHGFETGDYVTFTEIKGMTELNDCEARPIKVLGPYTFSIGDTRSYSDYVSGGIVQQVKMPKTIKFKSFRQSLMEPEFVITDFAKMDRPGQLLLAFLCLSEYLKRHSQSPRPRNKEDQEKFVALAKELNGNICAKVDEVDSKLLAQFADSARGDLCPMQGFIGGITAQEVMKACSGKFYPIFQHLYFDSLECLPEDGEVPEDQCQPTGSRYDAQVAVFGKDFQNKLGAQKYFIVGAGAIGCEHLKNFAMMGLGAGEGGNIYVTDMDIIEKSNLNRQFLFRPANVGKMKSEVAAKAAKAMNPNLNITSHQNRVGPDTERVYDDNFFEALNGVTNALDNIDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVLPFLTESYTSSQDPPEKSIPICTLKNFPNAIEHTLQWARDCFEGLFTIPAENVNQYINDPKFIERTDKLPGMQAVEIYEQIKKALVEDRPKTFADCVVWARLLFQEYFHDTIKQLLYNFPXDQVTSSGQPFWSGPKRCPHPITFDPREPTHMDFLVAASNLRAYMFRLIGSRDTTFILDTLKNIKVSEFVPKSGIKIATSEQEAEAERNASGDIDIDEIKNGIPPPADVKNLKMNPVEFEKDDDSNFHMDFIVATSNLRAENYSIPPADRHKSKLIAGKIIPAIATTTAIVSSLVSLELYKLVQGSKKLETFKNGFVNLALPFFGFSEPIGAPKNKYYDTEFTLWDRFEVQGIKENGEEMTLKELIDYFKEKHRLEVTMLSQGVCMLYSFFMPPAKLKERLALRVSEAVVKVSKKKIKPHVKDLVLELCCNDDDGEDVEIPYVRYSFRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPR2</accession>
    <name>A0A6P8HPR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Core histone macro-H2A.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116294174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557586.1">
        <property type="nucleotide sequence ID" value="XM_031701726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPR2"/>
    <dbReference type="FunCoup" id="A0A6P8HPR2">
        <property type="interactions" value="1553"/>
    </dbReference>
    <dbReference type="GeneID" id="116294174"/>
    <dbReference type="KEGG" id="aten:116294174"/>
    <dbReference type="InParanoid" id="A0A6P8HPR2"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000013">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000002">
        <property type="entry name" value="Core histone macro-H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Macro" evidence="12">
        <location>
            <begin position="187"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031557586.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="40214" checksum="797F8D0C9608FAC6" modified="2020-12-02" version="1">MSARGGKAAKRAKAVSRSAKAGLQFPVSRVHRYLRQVTHHYRIASGAPVYQAAVMEYLTAEILELAGNAARDNKKSRIIPRHILLAVANDEELHRLLKGVTIASGGVLPNIHPELLKKRKGGKLVAPEDLHPKKPKPSSPKKDAAVASTSKKPAPAKKAPAAKASATKGKGKGRGKAADKGPGDGISILSEKTLFLGQRLSVVQGELVAVEANAVVHPTDGKFQMKGEVGKILSKAGDEEFKKEMKKLAEENANFEVTQTAMCASHNIKASNIINVNCPVYDSQSEEESSESLTKAIKNVLTMADENNLKTIALPPIGLGDFKFPKQHAAQATLKAINNYFVSAMATSIKQIYFVLQDMENIGIYTLELAKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQQ1</accession>
    <name>A0A6P8HQQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294419</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557871.1">
        <property type="nucleotide sequence ID" value="XM_031702011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294419"/>
    <dbReference type="KEGG" id="aten:116294419"/>
    <dbReference type="InParanoid" id="A0A6P8HQQ1"/>
    <dbReference type="OrthoDB" id="6062647at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="1">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557871.1"/>
        </source>
    </evidence>
    <sequence length="900" mass="101870" checksum="C430A4C35E380622" modified="2020-12-02" version="1">MATASCPNEVLQASEGKTRFVRLARLLVCGGTTVMRELFDYIIPPGNLAAVLSSSPVKMRLTDMKRKRILTSPQWQKLYPPSGAGIQSTSFDITLLFKLLRENAISGLSPPSTGWDKLPSIGDLTLPADMARIKYYRNGIXHGDEKMELSEQDFRDYWNEIKDALVRIAGYYATSGSSKVRDWETAIDGLLTDPLTEDDRKNVDELKSWYLDERELKEMVDHIRLLLESSKNDRKVFSAKFVARTTTFGAWLGGNIYIFHRLKDHPDLLIDYVKYIFPATGILVYSVAFGCIKMTFKAETLDXLDEFWRRYETGQLKDDFEKILITEELKNLANGERIELSVDINKEKLTEIRKLLMEEEASKTIVKSFCLLPLKPSHQIINRLDEVSGLLEVIEHNKTNEITTAYLSGKPGCGKSEMARQVGMKFYTSIEDQTEVKFVFTFNASSIETLIHSYIEFTRILGCPKQSIAMVVTAKDACLEKKIMQLRGLASPKLEKYSSWMMIVDNVTDLELVSKYFPHKKKNTSGNGHVLVATQDSRAMTLDSNYTFFCSISPDMKTVDAIKTLKEISTFSKEQEEVFEVAKALDCQPLSLACAAIYMRNAFRTKESPITWTTFLEEHTKAATRTDVKTGLTCPASMKAAVMMALEKEISDSILMLAFQFLSVMAPEPISLEYVVQYVKACKPDTNDQVVAAMVRSSSLVRIPADGSTVSVHQVIHDCLQTVMSQHKEINIELLELLKMLKAFPLLRSYNTEDIEHIFTTSSLLIHFLTFIRRLEHLVERSLSSEILLKIPSEDKDTANSLFLVSDIIYTYGHYIASEICKEISETIQEGMSDENDPRLAETMKKLGLINLKTKKHQQGEKYLEKALAIQEKAYGHDDSHLATXAYIELSFITGTKLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR12</accession>
    <name>A0A6P8HR12_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin-like protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555100.1">
        <property type="nucleotide sequence ID" value="XM_031699240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR12"/>
    <dbReference type="GeneID" id="116292007"/>
    <dbReference type="KEGG" id="aten:116292007"/>
    <dbReference type="InParanoid" id="A0A6P8HR12"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555100.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18312" checksum="730563D862D886B4" modified="2020-12-02" version="1">MKPVDENDEEFLLKAFTEADRDNDGMIGVKTLTRTIRNLRENVEEGKVAALLKRSGIEVNKQSNDEPEINFGIFLKLYRQLSNVNDQDAELKRAFEEFDIYKRGYIEGSGIERVLTKLNIEYAKEEIELMIEVADTNGDGKVDWDEFLQIFKNGEDIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS14</accession>
    <name>A0A6P8HS14_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative sodium-coupled neutral amino acid transporter 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 38 member 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Putative sodium-dependent amino acid/proton antiporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557938.1">
        <property type="nucleotide sequence ID" value="XM_031702078.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HS14">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="GeneID" id="116294477"/>
    <dbReference type="KEGG" id="aten:116294477"/>
    <dbReference type="InParanoid" id="A0A6P8HS14"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="13">
        <location>
            <begin position="67"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557938.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56658" checksum="91CABDE86FE5A998" modified="2020-12-02" version="1">MDNEMNNSSIQTSAESQPKITEDLSFSDQTKMSINDPTLETLDSRTVTATESTPLLETEPEEDHGRHGTIVSSIFTLVSTMIGGGILSLPFAFQQGGFITTSFILFFVLLASTHGGFLIINSKKYCQGRIKNVEDVGRIAFGSKGELLTQIVLIITLFLCSVAYWILITDQLQPIFILICGRNSFWSKKIVVLTIPVLIVFPITLLKSMNALKFTSFLSVICVLFLAGAIIHQSSVSHLGGLIDDPKNPVKWWPENLGGFLTSVSITGLTFSCHFNILPMHSELRYQTRSNKRIILYTAMAITYTLNVLVSFFGYMQFRQFIDQDITKNYPHNSVVLTIGRCALSMTLLLSFPLLVFPCRDVINRLIWKEHSPVLMSNSVXRTMSYISNITITGPSRLVWFTETAFLVFVSYVLAYYIPQVAMVWGFVGAIGTTLTIYILPPAFYLRVRIHPPRPDLKQLAAWGLMIIGFIVLMVCTYQSVVNVVQPIPKILPLNSDNVTVSLHQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTV2</accession>
    <name>A0A6P8HTV2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melatonin receptor type 1B-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116295088</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558663.1">
        <property type="nucleotide sequence ID" value="XM_031702803.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HTV2">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="GeneID" id="116295088"/>
    <dbReference type="KEGG" id="aten:116295088"/>
    <dbReference type="InParanoid" id="A0A6P8HTV2"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031558663.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41467" checksum="6DB0190842599D6B" modified="2020-12-02" version="1">MNFTRQVNESLVNSPKKYYSYILQHRGTAEVALESGFLSLINAVTVMGNTLLCIVIYKNKCLRTLTNIFIVFLXISDILMGLFCIPFSVAVFIQGKWVFGNHICRMQCFFVYFLALGSLQTLTMIAINRYYRVLKPSKYKKVFTFKSTVGILILVWLSTGVFLAITLSTKAVLPDFSPVKGACVMFGNPKSSSAVIYSVNMTLVTIFAIIPTFVISFSYFRVFRVVGNHFIRVYPTLNRRGVNSTASSQLAPNIHDIKSTRTLFFILLAFAICWLPVFTIEVLQLFISWWKLPRSCHLLWTFCGSLGTAVNPFVFGITCRTFRKKFWAFLFPEGTNSSPEISTAPVKASRFIVSEFSLAGEVINTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV25</accession>
    <name>A0A6P8HV25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Octopamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116295522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559221.1">
        <property type="nucleotide sequence ID" value="XM_031703361.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559222.1">
        <property type="nucleotide sequence ID" value="XM_031703362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HV25"/>
    <dbReference type="GeneID" id="116295522"/>
    <dbReference type="KEGG" id="aten:116295522"/>
    <dbReference type="OrthoDB" id="5950491at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000368">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="32"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031559221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559222.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38702" checksum="E4F6DDAECED03137" modified="2020-12-02" version="1">MADNSTDVHGLTAIKIVFSVSLCVIAVINFIGNSLVIHIIRTNKLTKQPMNYLLVHLALADIMVGTFIPSRFIFTYFVSHPEGTTGAVICRMFTGGPPAWIAGLASIFFLVDISIERYLAVIHPFSRKWRIKWIKVKYIAIIAWIFALVFNCPYFFLINFVKEENFCYERWPVERLWLPQAYSTLWLLFGALFPAIIMICLYSRVIFTLWIKPGSVQFSQVGVLKFRRRATKMVVIVSLIYCVCWIPNLTLYFLYYIGVNYDFSDHHFIISNILITCNSAVNPFIYGFQSKKFRDELRKLVGCKNRVHSMSTNPQFLSGKNSKYIFTVDINKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV67</accession>
    <name>A0A6P8HV67_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116296421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031560299.1">
        <property type="nucleotide sequence ID" value="XM_031704439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HV67"/>
    <dbReference type="FunCoup" id="A0A6P8HV67">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="GeneID" id="116296421"/>
    <dbReference type="KEGG" id="aten:116296421"/>
    <dbReference type="InParanoid" id="A0A6P8HV67"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="118"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031560299.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="60477" checksum="40964CF52A8E1418" modified="2020-12-02" version="1">MVRFLHGTNQTETSSRSSSKAEVVQRDRKNGWSCPWHPLQLIAWLFLCFFAVTYFGIVVSYLPREWRPAAYIIPGGLYVIHITVHLLALSIDPADPHIRAGKSRDKNAFDRNLHAHVIENNHCHICEADVFPKSKHCSACNKCVSDFDHHCKWLNTCVGGRNYKLFVGCLATAFVGSLLMFSVTLYLFITYFTDNNALLLTQTGGQFKLFGPVPDTVFVVFVGAVEGLHITAIGLLGHLLGFHIYLMYMNMSTYEFIVNSRERKQQVNDVEAQRSCEGTPISLKRFRNKVRPTPEGMENGELSVERAQPEHSSSSEEPPCENTVKVMNEVSSKVAKRNSSLESHQNDGESTAVFENAAKEHNDTIPESVLSSSAESLREIENPQINIQNSSDIARPSTSDQTQYVRTSPRGKFDDAGVSKPCIIVSHSDKDNKEELSRKQLSDSEGEELMPVNITAPSHEPAKEEINNMDEENDISKKVSKKGKKKGKKLRSPSVQGKGLMEVNSQTRTRISEVNELPPLVPKGRRPLPSLDSYNNETSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVC6</accession>
    <name>A0A6P8HVC6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Broad substrate specificity ATP-binding cassette transporter ABCG2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116295596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559326.1">
        <property type="nucleotide sequence ID" value="XM_031703466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVC6"/>
    <dbReference type="FunCoup" id="A0A6P8HVC6">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="GeneID" id="116295596"/>
    <dbReference type="KEGG" id="aten:116295596"/>
    <dbReference type="InParanoid" id="A0A6P8HVC6"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008514">
        <property type="term" value="F:organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000622">
        <property type="entry name" value="ATP-binding cassette sub-family G member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF116">
        <property type="entry name" value="PROTEIN BROWN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="51"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031559326.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="73622" checksum="D6D5775063502DCD" modified="2020-12-02" version="1">MTDPAEDSNTSEAQNLKMDEENTPFLYGNTSPSNMALHGKNETFIETSSVITYHDICYTVKGVKVEGQKIDKEIIKKMSGIMNPGANAILGPTGSGKTTLLDILAGRKDKRNLSGTVLVNGKLQPNNFKCATGYVVQDDVIMGTLTVRENLSFSAALRLPKSLSKQERKERVNEILVDLGIMGVADQKVGTEFIRGVSGGERKRTSIGMELITSPSVLFLDEPTTGLDASTACSVMQLLHALGERGKTVIFSIHQPRYSIYKLFDTMTMLSQGEIVYQGPRADALQYFESIGYACEEHNNPPDFFMDVIHEKELHYPSNPINSSDVEGAHAINQGSPRANKNYDMAESYRKSRYFTHIQSAIQPIYREFIETSVGFKDVEEVKYATGFVTQLYHVSGRAVKNLLRNPQTSIMQLIITVLFGTIVGAIYYDQKKGPNGLQNRVGSFFFIIMNMVFGNLSAVELFIKERKIFIHESAGGYYRVSVYFLAKVLCDIIPMRLFPTAAFSAIVYFMIGFQRTLLKFVVFVLTLVLTSLCACGLSFFVSASVLTFANANLLIALPYVFMMVFSGVLVNLGSVGKWLSWVKYLSIFRYAIETLEANELEGMIFHCSFNVSCPTGDQFLKAQDVDPSHLWYNELALAAMTVIYLTFAYIALRLIKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY44</accession>
    <name>A0A6P8HY44_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116296392</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031560266.1">
        <property type="nucleotide sequence ID" value="XM_031704406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HY44"/>
    <dbReference type="FunCoup" id="A0A6P8HY44">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="GeneID" id="116296392"/>
    <dbReference type="KEGG" id="aten:116296392"/>
    <dbReference type="InParanoid" id="A0A6P8HY44"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="155"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031560266.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59375" checksum="1FCE39F5F6CDED3F" modified="2020-12-02" version="1">MGFKMASRNKILEEKPPEKRPVNGYHTKENGYVPRRNGEVKKDAVEFHEEFEETPLLVAVLTYIGYFVLVVFGYLRDFMRNYGIEKSKTSKEYANEGFVPLYSDFESFYTRNLYVRIRDCWNRPIGSVPGAQIDIVDRATDNYGWTFRFPGTQTKALNLGSYNYLGFAENEGLCADSAETAVKENGIAACSTRHEFGTLDIHVELEKMVARFVGKESAMVFGMGFATNSTNIPILVGPGDLIISDELNHSSLVLGARLANAKIKVFRHNDMKSLENILRTSVVQGQPRTHRPWKKILIIVEGVYSMEGSLVRLPEIVELKKKYKAYLYLDEAHSIGAIGPTGRGVAEHFGVNTADIDIMMGTFTKSFGAAGGYIAASKDIVSHIRACSHSAAYACSMSPPVVQQIYTSMKIILGEDGTNKGMQRIKTLADNTKYFRCRLKEMGFIIYGHDASPVVPLLLYMPAKIAAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTREMLDKALEAIDEVGDILQLKYSRKLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY62</accession>
    <name>A0A6P8HY62_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557547.1">
        <property type="nucleotide sequence ID" value="XM_031701687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HY62"/>
    <dbReference type="FunCoup" id="A0A6P8HY62">
        <property type="interactions" value="1637"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116294142"/>
    <dbReference type="InParanoid" id="A0A6P8HY62"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
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            <end position="122"/>
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    <sequence length="375" mass="43996" checksum="427498BF3FEF3775" modified="2020-12-02" version="1">MVDYSRWDHIEVSDDEDETHPNIDTPSLFRWRHQARVERMEEMAKERKAMDSKLAEKRKELEQLREKLSNASMSDKEGFQKHLDKAESELKELKKKDEELTKAEKKAPKNVDTLSHEGFTKTIINHPKPKEEETISAEEQEKRSKEFMDKYEKEIKHFGMLHDYVDSKDYLIKHPYLTCDDTANYLALWCINLQVQEKESLMERVAHQCIIIQYILELAKQLKSDPKATLSSFFTKIVRAKTEFPEYMDAFNDELQSFKKRVRDRAEARIEKAMKEAEEEERQQRLGPGGLDPVEVFECLPKELQDCFDKKDVGLLQEVLGKMPEEEARSWLKKCVDSGLWIPNAAETEKAHAEGGMDAEQEEKMYEEVKEPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Actinia tenebrosa</name>
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="RefSeq" id="XP_031560518.1"/>
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    <sequence length="263" mass="30732" checksum="6B659514AEC25369" modified="2020-12-02" version="1">MLDGTPNIHSCLQLSSENERIKAKYKKLQRKNTLLEKELNHLKGQLTNEWSTKSRAPTRSVHVQTDRKLISKQYVRPATTQALTKQPQDEGIEKSEKLLAMHTNLLKRYQKELKTNTAQVEQIASLTLENIELKQKLEETFNKLREQEKENETLQLRMKNITVKDRVTPSKRDLLADLEKVTKERNSLLQERKKFKGSFXFLLQGFFEEIEDLKYALQQSAKLNSAYEAALRRLCTQFGVPLPSVTGSGKKRHRKRQQQREFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYQ5</accession>
    <name>A0A6P8HYQ5_ACTTE</name>
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        <recommendedName>
            <fullName evidence="11">Diacylglycerol kinase</fullName>
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        </recommendedName>
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        <name evidence="17" type="primary">LOC116296629</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <lineage>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="17">Tentacle</tissue>
        </source>
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    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
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    </dbReference>
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        <property type="entry name" value="C1_DGK_typeI_like_rpt2"/>
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        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
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        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="EFh"/>
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    </dbReference>
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        <property type="entry name" value="Cysteine-rich domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="394"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="461"/>
            <end position="510"/>
        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="175"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
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        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031560533.1"/>
        </source>
    </evidence>
    <sequence length="943" mass="104265" checksum="2ABD1F2239F9F390" modified="2020-12-02" version="1">MANHSVPSSNAGGVWNRLSKDEFQQLQEYTKYSNTSRLTDVLKQFRDGVYPKYNPEQPMDYEGFKLFMFAYLGDDANEDICKHLFRAFHKEVPVMSLQSPSLSVGVSQTILDNMAAGSASKSCSSQDLTKPDQNRRVSELPGIHSGAGTAALVAAATAIAAGHGGDKPIIKLSKAKDEEPQKENNKNHDNNVNSKSKNETKDVTFSQTLSPQDSSTLGLGSWGKKSSEKHQFRRHSSGSFVAFKVANEHPPQQPRSSSQRKKTSFEQSTLLNASAPVKTVKMVSIREIACYLSMLEGGKVEDKLEFVFRVYDADGNELLDAQELECITQQMMNVAQYLGWDVTELKPILRDMLVELDDDCDGTISLEEWIKGGLTTIPLRVLLGLETQIRDDGQHQWRQKHFNRPAYCNMCHNTLNGFGRKQGLQCLFCKYTVHERCVQRAPASCINTYVKSKRTGKMSMDHHWVEGNCPGKCNKCNKTVKSNNCLTGLRCAWCQMVCHNKCATNISPECNLGLHRDHILPPTSISPAGLDKRSSTDVDSPKKKANSYASFEGMPMQITPLPGTHPLVVFINPKSGGRQGSRLLHKFQYLLNPRQVFNLGDGGPVPGLKFFQNVAGSRILCCGGDGTVGWVLSTIDRLQMKVRPPVAILPLGTGNDLARCLKWGGGYEGGSISKCLTQVQRGSVVSMDRWQMDVSDVDASETGDPAPLNIINNYFSIGVDASVALKFHLQREKNPEKFNSRLKNKFRYFECGTAETLSATCKNLHEAIELICDGTPLELPQLEGIAIVNIPSVYGGANLWGDTDKKKSKKVRGKGGSRENDLAWAVQDIGDGKLEVVGLENTLYVAQIIGGVRAHGLRLAQCSSIEIRTKRLFPMQIDGEPWVQPAATIKITHKNQVPMLQGPPPAKSSFFFKRKQARDPELESEIYPDQSNGQVKGCLGFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I253</accession>
    <name>A0A6P8I253_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative elongation factor E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116297732</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM NELF-E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561873.1">
        <property type="nucleotide sequence ID" value="XM_031706013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I253"/>
    <dbReference type="FunCoup" id="A0A6P8I253">
        <property type="interactions" value="2204"/>
    </dbReference>
    <dbReference type="GeneID" id="116297732"/>
    <dbReference type="KEGG" id="aten:116297732"/>
    <dbReference type="InParanoid" id="A0A6P8I253"/>
    <dbReference type="OrthoDB" id="378874at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033102">
        <property type="entry name" value="NELFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031561873.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30549" checksum="1039DB530CA1270D" modified="2020-12-02" version="1">MVLPKDLTPVEEYLLKKFALLKKKKRAIQKEKEKNEAIKTAKPGIKRAAPEPVHPPEDAKEIAKKLIASGTVKIKKDPTHREFKRTKLENRRISLREGQQGPNSNQQSANQSSSSSTSQKPQIRNLYDSFVPEGRRGSSDSGNYGSRGYGHDRERKRGKTIFVKAVGLTENILNTSFDKFGKVERTHFEKEKCHGFVTFDSYEAAEKAAEEMDGLKVSHVFMKVSMARRQGNLDDSHSYGRGQPFDSRDGRGGPSQSQIPEARQLISYEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4L2</accession>
    <name>A0A6P8I4L2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bleomycin hydrolase</fullName>
            <ecNumber evidence="4">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116295917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031559735.1">
        <property type="nucleotide sequence ID" value="XM_031703875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4L2"/>
    <dbReference type="FunCoup" id="A0A6P8I4L2">
        <property type="interactions" value="2459"/>
    </dbReference>
    <dbReference type="GeneID" id="116295917"/>
    <dbReference type="KEGG" id="aten:116295917"/>
    <dbReference type="InParanoid" id="A0A6P8I4L2"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031559735.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55798" checksum="60FED683816EB63D" modified="2020-12-02" version="1">MAEGSESALAGLSTQQISQIQTAFNCDPKNQLSLNLGTRNEPLDLCLSRQVVEKTNHVFNHKVNEVKPMTNQKSSGRCWIFALLNCVRQKFVQNMNLDEMEFSQQYLFFWDKIERSYFFLNNYVELAKKNEDPDGRLMMYLLSNPMNDGGQWEMLVSLVEKYGLIPKSVWPDSTSAIRSRRMNAILNNKHRECAMVLRKMVKDGASDEEIELMKNKMMAEVYRIVAICLGTPPSTFTWEYYDKSKNYKKIEGLTPLKFYNDYIKPVFTIRDKVCIVNDPRNEYNKLYTVEYLGNFANGPKVVYLNQPIEVLKYLAAASLRDNEAVWFGCDVGKHFEGKLGVLDLEIHNYDLVFGISLLGLDKAQRLVYGESLMTHAMTFTGLSYQDTGDQSGEKSGVEQKSEGEEKPVTLKPVTTTKWRVENSWGDDKGDKGYLVMTDNWFSEYVYEVVVDKKYVPAELLAILKQEPVVLPAWDPMGALACVHCGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5G9</accession>
    <name>A0A6P8I5G9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Girdin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563173.1">
        <property type="nucleotide sequence ID" value="XM_031707313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298767"/>
    <dbReference type="KEGG" id="aten:116298767"/>
    <dbReference type="InParanoid" id="A0A6P8I5G9"/>
    <dbReference type="OrthoDB" id="10058798at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563173.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="45201" checksum="C5A9A0BC91F04690" modified="2020-12-02" version="1">MSVQKRQSFEERTELDDRLTSKHIRTLLHLQDVHGEAERLKNRVAYLEICEIKAEKCDLLEKELEYLKGELLKCKNTHATAXEFKTRLEQMQKDSLARIDRSNRELTYKHEQEMMRLVSEKLEEANNWAMEKEKLVEKIKELEKENGGLNMKLEDLETRMQHTEVFNSKLEDTHCTLESIKKENSDLQEAKVTLQKGIRELTCENDSLRKSLDALKTKVKVLEVQLRQEQETREKPIEPKPEQPPPHLTLELKQLKDHISELEKTIVGLKEENAEKDQVIDSLEFSLQDSSQALKSLYKERDLLKXRIAVLLGEIEALRFQTPERKQTFSEFIQLKRDFSSLRDEHEKLLKKRGSKPNILPCLTADSKTVARTFSGNSWKSKASNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I718</accession>
    <name>A0A6P8I718_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560837.1">
        <property type="nucleotide sequence ID" value="XM_031704977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I718"/>
    <dbReference type="FunCoup" id="A0A6P8I718">
        <property type="interactions" value="2721"/>
    </dbReference>
    <dbReference type="GeneID" id="116296870"/>
    <dbReference type="KEGG" id="aten:116296870"/>
    <dbReference type="InParanoid" id="A0A6P8I718"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="262"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560837.1"/>
        </source>
    </evidence>
    <sequence length="1116" mass="126545" checksum="B29BFAF381C176C4" modified="2020-12-02" version="1">MAAASEFPSELSTRPFGLIALTGLDLTQKPLHKAIWESFSVNRRPERVPLSFKLVPIDHEYPKAKPKRTSYEWYIPKGILKTKWMNKHLEQVPALIVVFYELDWDNAQWKEKQNDCAAQVEKVRASIHGRNTKVAVVLIQKNAPLPPGEDMQAAERAAALCSACDLSAKSLFVLPYTDHLFGYAIRLENAFYELAQSYYHGEARKVKAHKEFLNKSTHQLLLVRHQIKVAFFNELRQDPHAAVKHYRQAYTLMSEIKLTDVNVLEVKVVAGYISYKICRLSFQGSAPLDAISQFRKHVDLWKEKRGCSELAFEHSAWLSKQFSLFGDLFDEAIRNGLTALQTQHPGFYYQQAANNAIVRRQLCEGLCHHPSSPISLEPLANAGKLDFYGQRPWRQGFQGAEPLDQPLEHNGILALQAQEMSVDHSWIIIPLLSSAVAQFKKYKSPRMKRYLMVQMGEEYYHARDYSKALMLLGRVTWDYRHERWWSLLTSVLITSLRCAYLVGNVQEYVTISMDLMGKYGLNSPEEKTRVQMNLIHVISNECPEPEPGCDVEAVEEAKEIWKSLAKQTGQVFTVQMDQIAAFVECKAKFDSPSIHADSAIILHIHLRATCPFPIRFSKLSVFFSNQAYNQYCCIDSSQGTDSEGGLYLLPAKTKVIPFKFYPQPEDVRKQLQVSSIALELGTQQGRCAVLVWNGGGTEGTTTLNCFAKHGNSHPDIEDQLDWEALQIASNILINPREPKMEIQLFHDSPTLVNEFFKVTLKVKSLEDTDVKDIRIWFGFQEEHDPSIVDTSTVCLEPPKTGQEAPVQSFVFFNRESMEKEMEQTYYVRCAQVGSRSLQAKITYSVTIPATSDSTPITCVCVKEKKISAKTVMPFDISLSLTSLRLERLDQVSEEEPFLLLASIKCSSPWPVTMVTTRLNLSSEVDFVGEKMNSQLEGVSLQQGESASECYCLAAREGSSSHKVVNIGSLVLEWRRASSPSDCPAVITELTFPSVTVESVPFFINTELPSYGCVQTLMPMSYVIHNRTLQVQEVEVTIEPSESFMFSGQKQVQFRLLPESDHKLSYNLYPLVPGHVTLPKLHLNLPRFQTNWDEHAQKMIPTQVFIKPRAKPVVQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7M1</accession>
    <name>A0A6P8I7M1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116299980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564579.1">
        <property type="nucleotide sequence ID" value="XM_031708719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7M1"/>
    <dbReference type="FunCoup" id="A0A6P8I7M1">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="GeneID" id="116299980"/>
    <dbReference type="KEGG" id="aten:116299980"/>
    <dbReference type="InParanoid" id="A0A6P8I7M1"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF51">
        <property type="entry name" value="ANOCTAMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="219"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="672"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031564579.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="80512" checksum="10A05E1F8BB863BB" modified="2020-12-02" version="1">MPIPERRTSAKAKTTAKDVFSTDSQNNWQKAGKFVLSSKLWEHSTPSQTCDVILTFPKDTEDYVVMWLLSRLRARVPEIDVHVRQMAHTPVYAFYLSASYEVYQNWAEELGFRKKLIGGGMVEFKVDEKEQFENHDDPTTFFTSGDKQTIVLEMINTLRAVDGDELGKIKFCEGMQIVPKLLSEGVIDKLFPLHNEDDLVKLRKTWVKAFFKPQPIDDICKYFGVKIAMYFAWLGMYTKWLIAPAFLGIVTFILSMRSEVTRDWCMLACNIFNIVWATLFLEAWKRRSAELAYKWGTLDMPSEALKDPRPLFRGEFKRSEITGSLEPHYPSIKRNIFRYCVSLPAILVSLGVVVVSMLFCFEFQRWVDKMENPPKPLKFAPKVLLAVCIGQLDDNYKKLAYFLNDKENYRLQENYENHLIIKLVSFQFFNAFLSLFYIAFYVRDFPRLKNTLAALLITKQVVGNVKEALVPFVKQKVKEWKQKKKMEKEKKELAKNQPADKKTGDKPKELDTPLMNQAEIESNMPEYEDTFEDYLEMFIQFGYVVLFSSAFPLAALCALLNNVIEIRSDAFKLCTNLRRPFGEKVENIGTWQDAMEVMGVVAVMVNLALLGTGGSIQRMFPNMTTAETILLIVFLEHLVIGIKVAVAYAIPDIPEWVETEIAKVEFKRREALKGKPAPAAPQTPPASPTQEGPTEAQANTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9U1</accession>
    <name>A0A6P8I9U1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116299431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031563951.1">
        <property type="nucleotide sequence ID" value="XM_031708091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299431"/>
    <dbReference type="KEGG" id="aten:116299431"/>
    <dbReference type="InParanoid" id="A0A6P8I9U1"/>
    <dbReference type="OrthoDB" id="6119432at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="93"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031563951.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="60976" checksum="2B744C3AEEEE3581" modified="2020-12-02" version="1">MGDLFDKTREXTLELRTAGHHVVEMWSHVWDAEREYHVFPEWIKNLDPIQPREALMGGRTNAVGLYAYCEGEVQVDESDDEAIALMLCSDPVHRILYVDVVSLYPTVMWEEEYPIGHPMVYVGEDLDLDPEEIADCILDEEWFCLVKCDVDPPRGLFFPVLSRIADHKLMFTLCAACCDEKDVEENEGGECTHTIEERRLRHGVWTTPELKALNQGYEVAQVHEVWHYPDRSSDLFQSYIRENLKMKMEASGWPSDCDTEEKKREFMRSVKTSQGVDLQYEXVVKNPGLRSVAKLNLNSLWGKFGQNPFRGKVEYVTEPCRFFELLHDDTVNVKTVLLLTGDMVQVNYDVPRESTVCNPNGNVVIPAFVTAWARLRLYDKLNALGDRMLYHDTDSIIYKTEQEGDEELETGDQLDQWSDECGDSETNWIVEYVSLGPKTYAYRTKNGECVVKCKGISLTPCAKELVHMKSMKRLLVQENEKVTVSYPRKIVRDSAHKVLRTVPMDKDVRLVYTKRQRVDQGLTTLPYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9Z5</accession>
    <name>A0A6P8I9Z5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="45" type="primary">LOC116300201</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="45">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40919"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72841"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40920"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
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        <property type="project" value="UniProtKB-EC"/>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 43" id="KW-0812">Transmembrane</keyword>
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    <sequence length="616" mass="68647" checksum="0CEB612F0AEBC367" modified="2020-12-02" version="1">MNLLWAPCGVFHHFSFVSAVPMYSCLISSMASSYSNTSPWKPFLFLLSLLLSVSDATDSLPFINATSVDVGFLWEHPRQENHHSTRVIIADNHLKSVLSLICFISPPLPHTPEYEDKKNELVRWEKITTRGAEAVNNVRYWASDRTTVAIKYDNITSDVIGSYTCSYGQLSKLINVNVANVDIVKALKMPTMYEEVKNYATHMEDTTGIAGWNNDKSLSQSKGSSLSCKHAAVIKSKDSPATIHTVRPADITVIAAVGDGFTTGLGARATSWNGFFTEYRETSWSIGGEGHLNQTTTLPNIFREFNPGLKGYSTQAMNSLELNMATSFSSSWDLEKQVNQLITTMQSNKEIDFKNDWKVLTISTGVTDLCHICKDPDRFSGSHYIKNVMHSLNILKNKVPRLYVNLVPPMDVSVLYGLYDKNPSCHIMQWSACPCAARQDKAANNVVSKAAKKFTSLLEELVNSGIYDLTDQFTVVIQPFMKGGPKDKTGGLASRVFGPDCLHFNTEGHAAAAIALWNNMMEPLHDKNTIWNTEQTPKCPMNGQQYLSTKVNSNVVTTFDSEDDTSTDIPPAAAITLSVFLIAVVLSITFYVWRSRKSRPYTDTMRLLEFPYKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAA5</accession>
    <name>A0A6P8IAA5_ACTTE</name>
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        <submittedName>
            <fullName evidence="8">Collagen alpha-1(I) chain-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116299574</name>
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    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Collagen_Structural_Proteins"/>
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    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
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        <property type="entry name" value="NC1_FIB"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564106.1"/>
        </source>
    </evidence>
    <sequence length="1659" mass="155332" checksum="1052A208497DCECE" modified="2020-12-02" version="1">MGFSFSWIAVSLCVAAWVVSTSGQVPQILDPSLKGEKGEKGRTGPPGSPGRPGAKGNPGDPGIAGEDGGPGINGPPGVRGDIGPPGLPGRPFIRRVGIPGKPGSRGARGKNGLPGPEGLPGEPGEPGAQGVRGEPGDAGEQGPPGKEGRTGKNGTSGLPGVRGEPGPQGSAGPKGQQGPKGVTGFKGDTGRVGRPGPKGNRGDAGFKGDRGRAGSAGKNGTKGAAGAVGEPGNEGPRGFMGNVGVIGDRGPSGPPGPQGLPGTQGLPGQPGDKGAGGEPGLEGERGIQGLPGPQGPVGVAGEAGQPGESGRNGEPGQKGAKGPQGIAGPQGRPGAPGRQGNPGVDGLAGSRGKRGEPGRAGQRGLPGASGDRGDQGRRGLQGPQGQAGRPGRRGKVGNQGTPGSVGPTGSVGPRGPTGASGNTGLDGDVGERGETGPDGVKGDRGPDGIPGEDGIPGPRGPPGTSGQSGAEGKDGAKGEPGKNGENGAPGPSGPPGISGVMGTSGQKGEQGAPGVAGNAGPQGPRGAPGARGAFGALGDPGTPGRDGASGQRGEPGPTGATGLAGPQGEPGPAGPPGPDGKRGAVGERGQDGLNGQAGVPGPQGERGPSGLNGKPGEKGKQGEPGVDGTPGDRGEQGSPGPTGSAGAVGNPGRPGQPGPSGPKGDVGDPGPTGPRGHPGSDGKRGFAGTPGKPGPVGPRGLRGTPGNAGLPGVPGQAGLTGIRGPPGPPGRPGDNGNQGPAGNIGRPGPVGEIGEPGILGDPGEDGEQGESGPRGPRGEQGLKGASGLIGSMGSPGLAGEPGNPGPTGLPGPQGPQGPDGERGLDGEKGDPGANGLNGKRGIPGQSGRDGKDGIRGRRGEQGRAGDRGSTGEPGNRGEPGQPGAPGSQGPPGPRGAQGPRGDTGESGRDGNDGPAGATGPEGPQGTSGRAGFPGNDGIPGGRGSHGVPGPPGLKGVKGYTGVIGKKGVQGPRGRTGSQGPVGDRGRPGAPGTNGEDGVDGAAGPIGVTGETGAKGSRGIQGVKGNKGEKGFVGSPGQVGFTGKRGPEGDPGTPGPVGSAGDKGQDGPAGVTGPHGYAGAPGPIGLKGVTGRPGPDGFPGQDGRRGPPGPPGPRGEPGVAAPRMFQVSRAGPNKGPAPLVPGGTGGAGGAGGGGPGGGGTGGGGGGGLGGGGFGGGEGGAGGAGGGGGAGGGAGGGGAGGAGGGGIGGGGGGFTTGGGGGTGGGGFTTGGGGTGGGGFTTGGGGGGGGGGGGFTTGGGGGGGTGGGGFTTGGGGGFTTGGGGGGFTTGGGGEGGGGFTTGGGGFTTGGGGGDGGGGFTTGGGGDGGGGFTTGGGGFTTGGGGGGDGGGGFTTGGGDGGGGFTTGGGGFTTGGDGGGFTTGGGGFTTGGGGDGGGGFTTGGDGGGFTTGGFTTGGGPARQKRSLGDTGVLDVVSEESTDEWSRVALELSESVMSFERRDGSKKYPAKTCKDLSTCYPQLPNGHYWIDPNMGSNKDAIRVFCNMTTRSTCLSPKTQISRKKWNTQITRGYSWFSDDLNNGGKIEYGVDEVQVSLLQLLSNKAEQKFIYHCKKSVAWYDVVSASAKKGLKLMGANEYEFSSISNRRARPKVLLDECKIRDSQWRKTIIQLDTTKSSRLPIVDFATYDIKEGEFGVEVGPVCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAT2</accession>
    <name>A0A6P8IAT2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiple epidermal growth factor-like domains protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116297683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561820.1">
        <property type="nucleotide sequence ID" value="XM_031705960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAT2"/>
    <dbReference type="GeneID" id="116297683"/>
    <dbReference type="KEGG" id="aten:116297683"/>
    <dbReference type="InParanoid" id="A0A6P8IAT2"/>
    <dbReference type="OrthoDB" id="10551389at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07546">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EMI" evidence="3">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031561820.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11236" checksum="047F70471F15DFDB" modified="2020-12-02" version="1">MFLFFRQTTQNGLVKNGTNVCKKTVSFQQSFSSAYDSLQIYTYYTSCGFLWASYCARYRYYYTTHYRTTYGISYRKEQQCCKGWSQVGDQCTKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAZ0</accession>
    <name>A0A6P8IAZ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 27-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562452.1">
        <property type="nucleotide sequence ID" value="XM_031706592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298209"/>
    <dbReference type="KEGG" id="aten:116298209"/>
    <dbReference type="InParanoid" id="A0A6P8IAZ0"/>
    <dbReference type="OrthoDB" id="5872154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15727">
        <property type="entry name" value="FYVE_ZF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF9">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562452.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="49155" checksum="3B104591482DD5F5" modified="2020-12-02" version="1">MARANCIRLEDNDVFPAKTEGPANVFSSTPFLLVKPRWMADEEAHVCPHCSQKFNQLRRKHHCRQCGRVLCYKCCNEKVPLPQMGFEDPERVCDFCLPVTSLVTKSRSLQLPFKLEAAESLKDMCKDPXNLKKAAVSEGLRILSTHSPLHPMLAKCGAIKAICSILSTTNETQEQTLLDGISALMIFCKSEELKAQALADGALNPVLSLCAMKEAIALLAMMTLSHIVEHHGNLAPLIESDRNALPRILALTKANDEKIQEISLRILSQMSMGTDWQRHRIVQEDFSAGRCLVESLRRGPKNLQVLVNASSLIANLALGEQDQMSLRDCLEAMCSVMSSHAEHNDIQTHVSRALANFSTFHQNSAILICSLSQVIQIHLKSTDETIRCHGLRTVMNLLSQQKDQTVATLMREGAADVLMALSSFPGIINAIQTSLLHVVSPLTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC07</accession>
    <name>A0A6P8IC07_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ergothioneine biosynthesis protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116298181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase-modifying factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562420.1">
        <property type="nucleotide sequence ID" value="XM_031706560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC07"/>
    <dbReference type="GeneID" id="116298181"/>
    <dbReference type="KEGG" id="aten:116298181"/>
    <dbReference type="InParanoid" id="A0A6P8IC07"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120147">
        <property type="term" value="F:formylglycine-generating oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1580.10:FF:000008">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027577">
        <property type="entry name" value="OvoA_Nterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051043">
        <property type="entry name" value="Sulfatase_Mod_Factor_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04344">
        <property type="entry name" value="ovoA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150:SF26">
        <property type="entry name" value="GENERIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150">
        <property type="entry name" value="SULFATASE MODIFYING FACTOR 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="6">
        <location>
            <begin position="30"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="5">
        <location>
            <begin position="202"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562420.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="85226" checksum="22B6850E28547BC6" modified="2020-12-02" version="1">MTSPFQVLSSIPCDLACLSIATMSDVRSYFENTYDLYENLFRGIKDEIAYFKYPDALRLPLIFYYGHTAAVYINKLMLAGLIEERVTFEYESLFETGVDEMSWDDTENFRMGGKFVWPSVSEVQKYRDDVKKTILKLIDTKPMDVPVTQDSPWWSLFMGMEHERIHFETSSVLIRQLPIEYVGRPDNWEYGPLTADPPVTKTSMLKVQNCTVTVGKPRDFPSYGWDNEYGEWTVRVPEFEASKYLVTNREFLEFVEAGGYENKTYWSDEGWKWRSFRKAKHPSFWVCNQACKSGCGNDLADYSHCCLATSDNDINGNEYHLQYKYRAIFDVIDTPLDWPAEVNYFEAKAYCAWKGPEYRLLTEAEHHAIRGPQKPVCMGTASDPLYQIDFKANINMKYASSTPVNMFPASETGFHDAFGNVWCWTEDQFNGLPGFETHYLYDDFSTPTFDGKHFVILGGSWASTGDEASRFARYAFRPHFFQHLGFRVVRSVNSTPPPVRLVSTSVYIPGVGVEGNRVQIPGIEDGEARYPSTNKQYVNDTNEFLQEELAKQYGDESIDPFTDLCLEYVSQCNCATGSALNLLCSVGRQAFELSKHFDEVLGIDYSGRLINAAQNLQKRKGMGLGSSGMLVEILEGANAERVTFKQLTWLPNEINKFDCVTFRGLDRLSCPEAWLARMREIVNPQGLVVIETSQNCDSEKVACFFGNSFYLLEKKVISKVINDSKNEGLRSCDRCHSSIAMIWTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE43</accession>
    <name>A0A6P8IE43_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cystinosin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564862.1">
        <property type="nucleotide sequence ID" value="XM_031709002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IE43"/>
    <dbReference type="FunCoup" id="A0A6P8IE43">
        <property type="interactions" value="817"/>
    </dbReference>
    <dbReference type="GeneID" id="116300191"/>
    <dbReference type="KEGG" id="aten:116300191"/>
    <dbReference type="InParanoid" id="A0A6P8IE43"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031564862.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24851" checksum="8922FE877A2365A1" modified="2020-12-02" version="1">MFWIPTVEHQYEKQHPGGINPVQLNDVVFTLHAIAVTLGTIFQCLIYDRGGQRVSNICKVLVAGSWLFAAIALVVTLTNKITWLTYLYYFSYIKIGVTLIKYIPQALMNYRRQSTSGWSIGNVLLDFTGGSFSILQMFLLAYNNDDWKSIFGDFTKFGLGAISIMFDTLFVVQHYCLYPSKEGYNPIDGRHEVTMPDGSLDRPVEGSQEPSVNRKHLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEB1</accession>
    <name>A0A6P8IEB1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin--tyrosine ligase</fullName>
            <ecNumber evidence="11">6.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116300315</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17605"/>
            <dbReference type="Rhea" id="RHEA-COMP:16434"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149554"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.25" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031565062.1">
        <property type="nucleotide sequence ID" value="XM_031709202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEB1"/>
    <dbReference type="FunCoup" id="A0A6P8IEB1">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="GeneID" id="116300315"/>
    <dbReference type="KEGG" id="aten:116300315"/>
    <dbReference type="InParanoid" id="A0A6P8IEB1"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004835">
        <property type="term" value="F:tubulin-tyrosine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052492">
        <property type="entry name" value="Tubulin-tyrosine_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46570:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031565062.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44109" checksum="33AFE2C86CFD6EC2" modified="2020-12-02" version="1">MYKFVNRDEGSSVYTAVGEILLGRHGGQWARVAKDSERFNLILAERNRPPYTRLGHHPGLTQAINYYRGSSKLLCRKASLVRTVRSISEANGLSPYRWMPLTFIIVPTNMTKSMENEKTKRSTSCKDERELFLETFKSWEPCGKNIWIGKSTAGAKGENIFLTSEANEMLKLIDGERQAYVVQKYIEDPLLLDGGRKFDVRVWVLLDHLYSIHVFSEGILRTSSEPYDVENLANMTSYLTNHCVQESQSRNFGKFEKGNEMFFSEFSSFLKKRYDVDFKEKILTQFYAIIKECLLGIKEEISTVGLSYDSFQLFGFDFMIDRQFKVWLLEINGAPASASDLLQSMAIEIVATAIDPIFPPSRINKDQSTETNSYMNGFFINISDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG85</accession>
    <name>A0A6P8IG85_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565716.1">
        <property type="nucleotide sequence ID" value="XM_031709856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG85"/>
    <dbReference type="FunCoup" id="A0A6P8IG85">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="GeneID" id="116300890"/>
    <dbReference type="KEGG" id="aten:116300890"/>
    <dbReference type="InParanoid" id="A0A6P8IG85"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="221"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565716.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61174" checksum="1055BAC4EF950BE7" modified="2020-12-02" version="1">MKRVKVVRHNLSEVISKGMAVDSVVPHLSRFLHDDPWVQPFVGEIERRYKCFQSIKGDIEKHEGSLDAFSRGYEKFGITRTAEGQMYREWAPGAHGVFLIGDFNDWNRISHPCTKNEFGIWELNLPNKSDGTPVIAHGSKVKVGIQLASGEIVDRISPWIKYAVAPEDNILYEGVHWDPPEPYCFKHPRPKPLKSLRIYEAHVGISSNKPQVASYKHFTKHVIPRIKYLGYNSIQLMAIMEHAYYACFGYQVTNFFAVSSRYGTPDELKELIDTAHGEGIVVLLDIVHSHSAKNVMDGINEFDGTQSCYFHDGHRGVHTLWDSRLFDYTKWEVLRFLLSNLRWFIEAYKFDGFRFDGVTSMIYHDHGLGHGFSGGYPDFFGLGVDTESLIYLMLANDMLHTVFPEVITIAEEVSGMPGLCRPINEGGGGFDYRLGMAIPDMWIKVLKSTKDEDWKMQDIVWQLINRRHNEKTIAYAESHDQALVGDKTISFWLMDKEMYTHMSVTSPLTHIIDRGIALHKMIRFVFGSTVKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGQ2</accession>
    <name>A0A6P8IGQ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC116301045 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116301045</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565905.1">
        <property type="nucleotide sequence ID" value="XM_031710045.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565906.1">
        <property type="nucleotide sequence ID" value="XM_031710046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301045"/>
    <dbReference type="KEGG" id="aten:116301045"/>
    <dbReference type="OrthoDB" id="2161974at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CortBP2/NAV1-like AAA+ ATPase lid" evidence="3">
        <location>
            <begin position="2158"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1154"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1702"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2278"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1519"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1623"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1702"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2278"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2308"/>
            <end position="2318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031565906.1"/>
        </source>
    </evidence>
    <sequence length="2341" mass="261987" checksum="D58457D3F3ABB256" modified="2020-12-02" version="1">MASNVNVIHRSNRGRTGLDVKAKTDSGCFVDDELEKQIQGEKSPPRKKDDLKIAKTNNQDTNILRFGSSKKSTQLENSSVPQNVVEGEEMSRGSESPKNKEIQDDLQGDIDFERSLENTEPREDFYCLYYSDSPNGSLTGSKDKSNYDQEGDNIGATAEELLKKIKEDALKGSPNAQDVEVQKFGFDQPPPIAPKPKRSSKQQNNSNISGIDPILAELEMLGSAVGRDFTSVETDDRDEGLLSNAVKGLHVAETPEECFDKFGDIQTALNENIPDTLERSKARSKKDAPRRKSLPEENKPENPSESRKGEEKGSSQNGKIAESPKLGKTKLQPKKFSRSEIQSLNSMREDSHHKRSHLNADNSKPVPTRSETYKLNRPDVSKQLSERGDSNKANVRKDPKLTSPKVGKPSPKKAGSKDVAKKRERLELRSGRRRRSGDLTSIPENAVMDDGKERRKSDAAIPLAKGEEDLSSEEEDLINDEDTPSERTIEEKLPPRSSYLTPTCNGETSVVSTSRTNFTCSTTTSSNTRTNIEGMTRSLPSQREEKTVPSNTSFTPRPFKQPGRFYNYRGRDHLSDGWTSESTAGYSSECSANDADDEGDKQVELELTENLQAYDDPNDIVDMTFGSQMDDHPEIEEPYVFGEEPFQQAERNDFVEATDAAPMYYYPEGSQEEIGDGEFAFPRVLSMQDTVGIPDLYEHYQSEDGAYPGTSHSDLVFPCADNNLRRQTVRKSTSEEHVQPSATKKPNKFQKEEGPDPSGFMTVEDIKRLIFQGAKPSIPRSTSCYGISSSRRRSQEQEVFQRRSWSGYGSQQQQEPGIDPLVRNFPQKSQSSQRLPKGQKSPYVRTIQPQRPTPQLGYYSDTQLNTVDQEEERFLEPSRSFHRTPLQRRAYSLETYHSDNSIPDEVSSPVVRQSDRSHLLVRSASDCSANYSQRQPYGQLQSPPSNRSPMPQYIDTKELANLVSSRSSYASGRGNVVTPPQRPYMNPHGAQYQIPQSQRGDTPSLPRYSSEELRIQALRRASQRSSDSDSEVSVHIGLPARSNVDPPSHQLKLGVVNSPTQKTLSERFSEVPQRVTFEELAEKLNLSSDSSEEDEIDYGSVNGKADSEFGADLEFDNGDYFDDKNMIVGEALRLKKVLGQSVPEQDPELETLVTATTDPKLPEPPQSVYEATSPKSSVRQPSDALVFESPPPYHEVRRKTSETSGSESCGITLVYDVPPLYESETESHPESTKMKEKLRVDLRDETKEHLQLLERRDSETQTNGGQQPTEKAISAEELLKLLLNASQGNLEKTNAPPSSQAKSQQLVQNLYFPKPQTKAASTGNIHSEEKFPGHVAQLYGNSDLNSARSSLRRRLPEPQRPTCHKSQECIRYKHRLNRPVGGVLQAKMIGSEANTKKQSKRIFEEEVDCMKTKGAFGFSSGEISTSGSSIDDVENKKDRLTSVSFVGCEDTKEIETLPKVKFSSQRKRTKARTGYLSDQDIPTAVQNGGDKEIRFKRSSEGLNGENIRHIEQAMVQKPSENKYRDSKYEKQSLRKEMPCSEDKDVQKIKDQNRPEIIDLRSYNDKENESQERSDNSDYAVHEFPHDNRPSPNSVNVFIDYNKKNVMKITTSTPKVHHAKLVTPTPQGISPVSNATNCKTSSPHENGCSYGEEEFPPRYETSPPIDRSSSVYSSDDEKFFGSSDTVVFVDKTAEKSSVKPNVDNTTVVVQDQGASSSNGDRSAQNDEAAKAQEYCERVDFLLQEVRSSLDLDSIGSDLLDQAMERVKDKLSPRSSQNQGRGSITMEAFVALHQADELQAIINEIKGELWILQQENTLLKEKVVSLQHGEACSSSESTEDSLTESAERIDSIRRQIAAVAASKKRASECEDTELISVDVFLKGFGCALAVRHSKKMNVKLGTVKVRGGTDWGGVYDAAKATFLDHVKRIDPCSCLGLGPTSMYGAQIGATMLTPETLRRKDPRVEISRKCNSCVIQLKDGMSETFDTLVYETLIPRHVVESFIHQILENRFIVLCGAAGLGKTFLATKLAEHLAQRFGSKNESPVLTLAVGQTSRKELKKTLADLMKCDISSPSHGVPVVVVLDQLDCLASLADIFDPKQLEGNRNSPFIIGVRNKSKKGPFSSKDLAVYKYFRWIQLAVHDPFVLGLLERFLRRKLSWADDVEDEEDLLDLFLWLTHVWQRINQILQSYVDIDVTIGPSVFYSCPMDMCAAEGWFANVWNYTIIPYLHQNLRNSSKIYERNEPWECPTKWVIMRWPWNRDKSKVLGSLKKLRQVDIVLNRNQQSPKGNTKGSQSKMRKQLLSSKLAKNPSPSKAGSLESWSTADWDAVSMTSDVESIASSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHG1</accession>
    <name>A0A6P8IHG1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 4-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116301318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566216.1">
        <property type="nucleotide sequence ID" value="XM_031710356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301318"/>
    <dbReference type="KEGG" id="aten:116301318"/>
    <dbReference type="InParanoid" id="A0A6P8IHG1"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF296">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN DEL-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566216.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54885" checksum="1E25601E1FD34B28" modified="2020-12-02" version="1">MTDTRKDDENKHLAIDIIEDFSSYTTLHGINSISHSKTRAGRMTWSMLLVFAFAYTVKSTVSSFIRYTKHPFSTEVTEQFAGDSGLKFPTITLCSMNMFVKRKIQLPDDDPLFHKYGLNLDICNETKVIRQAYNMTCGNLLMCSADAPEFHPGHGCGRADKLMKAIIATKSGNNFSLNFDEQFRKMYGPKLETSTRLCRFGQVRCTAKDFTGYVTNHGNCFQYNGDVDNASYSFGKESMTLILDAKLDDYTKTPQFTEGFKFYIHDQGTFNSPEGGFVVSPGNIATVTVPFKSNCTKRNLQNYRTYTIGGCLNECFQDMMVQRCGCRTSGYTLRNGSPGTRVCTAYDKKCKRRLMRAYFNPKLCDCLPPCNQTTYTYQISYSSFPDSGTKEMMXKYGKMRLEYIRKNLVAITIFYQATSYELHEQKGSYSLEAFLGELGGNLGLMVGCSVLTGAEICQLIIQLVFNTLGNWIQRDKRKVAWMEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHK2</accession>
    <name>A0A6P8IHK2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301254</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566150.1">
        <property type="nucleotide sequence ID" value="XM_031710290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHK2"/>
    <dbReference type="GeneID" id="116301254"/>
    <dbReference type="KEGG" id="aten:116301254"/>
    <dbReference type="InParanoid" id="A0A6P8IHK2"/>
    <dbReference type="OrthoDB" id="10318809at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566150.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13353" checksum="495E0DDAFD1819BF" modified="2020-12-02" version="1">MIGRSATRCAANLSRISSSHSLLRAAAKLCKSGTNGVKRASTLSATLQSRLAKGSMPNSSFVAVQEKYGKFLSKNFSAISAACDSPQVLVELLIQTGISTDLQEDDEEMSSVSGKKKHRRKQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIT0</accession>
    <name>A0A6P8IIT0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein C12orf4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116301492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566423.1">
        <property type="nucleotide sequence ID" value="XM_031710563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIT0"/>
    <dbReference type="FunCoup" id="A0A6P8IIT0">
        <property type="interactions" value="2165"/>
    </dbReference>
    <dbReference type="GeneID" id="116301492"/>
    <dbReference type="KEGG" id="aten:116301492"/>
    <dbReference type="InParanoid" id="A0A6P8IIT0"/>
    <dbReference type="OrthoDB" id="415359at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031566423.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32746" checksum="A390818347D8A301" modified="2020-12-02" version="1">MPEEFKAEPEAKIEESFTIHLGAQQKTMHNLRLICGDVLDMCRHKTPPGGSVFSQPHRIQTALSLYSETLAGLVLLVDNRLDSYTGIMKDFAAICQQSTEFHFPDLDKQLCLIQQSVEHRKRTKSSTSVTARVQRPTEEDALKVPTLNAGDFYITHHSNLAEAQVVFHLIVDDTVKSASLNSRNPSIVGLRHVLHTAVRYNITTLTIPLLLFHEMTDEMTVNWCVKRAELVLKCVKGFMMECASWSGVESLNVQFMIPKGISLDMFNTISNMLPNIFRISTPLDLTSTSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ09</accession>
    <name>A0A6P8IJ09_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Adenosine receptor A2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116301776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566754.1">
        <property type="nucleotide sequence ID" value="XM_031710894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301776"/>
    <dbReference type="KEGG" id="aten:116301776"/>
    <dbReference type="InParanoid" id="A0A6P8IJ09"/>
    <dbReference type="OrthoDB" id="5981126at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="33"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566754.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37221" checksum="8CEFBBDBD6CADAEC" modified="2020-12-02" version="1">MENETGGGEVHDPTTTYTVLGLYGVLDITILAANILVLFLVYKKRNLRTVTNNFLVSLAVSDLSTGLIAIPSSIACSLTVTENTCIAMDICIRFLAFSSVTHLTVLTLERYLRITKPFAYRSRVTGKSTYRVIFGMWGFSLLASLVQLSWIKNLAIDEKDMIQIEIIYDCVSFAIVVVIPLFLISGIYIAIFRFIRRHNARRGEVLATSTSTSSQKKANAKNERKLLLVFLAMIVVFILGSFNYFFWAXLLDLHEHHSIRFTSNTYNMVVRFTMFFRYFSSLCNPVLLTFFKQDFHEALMVVVGRRRVPREKRISSKEETNATSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJD2</accession>
    <name>A0A6P8IJD2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor SOX-30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116301952</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with CTNNB1, competitively inhibiting CTNNB1-TCF7L2/TCF4 interaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566986.1">
        <property type="nucleotide sequence ID" value="XM_031711126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJD2"/>
    <dbReference type="GeneID" id="116301952"/>
    <dbReference type="KEGG" id="aten:116301952"/>
    <dbReference type="InParanoid" id="A0A6P8IJD2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22033">
        <property type="entry name" value="HMG-box_SoxH_SOX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000027">
        <property type="entry name" value="Transcription factor SOX-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052856">
        <property type="entry name" value="SOX30_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47279">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47279:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="13">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031566986.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37825" checksum="1820B79AB50A72A5" modified="2020-12-02" version="1">MGQTFLRMPHICHTVQAQMRQENAHKVKRPMNAFMIWARQNRSTIAKRYPSANNAEISVKLGEIWNDLSSGQQKPYFDEAARLKEKHKIEYPNWVYQPRPAKRPRTVELPGSNACNAGQLSAKALPVKTEVPQTQSSFGVRHKQGHLSHVQPFFTLQGAEAAKPTLTQSLPCTITSTGESNRGSHGFINLSNSTIDHRLIKHIFEQSDGISPENSASQSETELKDKKIGSCNWLDREYRKIESGTFAQTHTQRPEEDGEVVKQDAMLTSVEVNEVENEELSYDNCELDKYLAGLDETIKKSLEKLNEVPDELDLLDDDLDKKFAELEDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILZ3</accession>
    <name>A0A6P8ILZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glycine receptor subunit alpha-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116302472</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567630.1">
        <property type="nucleotide sequence ID" value="XM_031711770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILZ3"/>
    <dbReference type="GeneID" id="116302472"/>
    <dbReference type="KEGG" id="aten:116302472"/>
    <dbReference type="InParanoid" id="A0A6P8ILZ3"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000045">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="227"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031567630.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44971" checksum="80499268F9C36F1F" modified="2020-12-02" version="1">MVIYQDPIASLTLFCVDYVHGYDVRSSSAGAAVAVDVEAYVFSMGSFDEQKMEFSMDMFFRQRWTERRLCYQARPGKGPNQRLVINPVLVSNVWRPDIFFKNSKIARFHDVPNSNVMYAISPNGDVLLSVRITTTLGCQMDFRRFPFDVQHCDFQIGSYGNTEDDVIIRWRGEKGVIIADSVEVLQYTISNITTSNAKVVYNTGTFSEPKTVFVFSRRLMYYMFGYYVPAVLICVLSWISLWIDPRSVPARVSLGIITILAMGSFLHGSSGPKVSYATALDIYIITCYVFVFASLLEYAMVHYGLTCCEKLGIVEKNTVFTNTEVDQNGNVRDENSTSISMATIGSNTGPSLNKRFQQCKLSYFKFNAFSLEKYARIGLPVAFVLFNFGYWLYYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM56</accession>
    <name>A0A6P8IM56_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC116302699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116302699</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567912.1">
        <property type="nucleotide sequence ID" value="XM_031712052.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567914.1">
        <property type="nucleotide sequence ID" value="XM_031712054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM56"/>
    <dbReference type="GeneID" id="116302699"/>
    <dbReference type="KEGG" id="aten:116302699"/>
    <dbReference type="OrthoDB" id="10370302at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567914.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42710" checksum="B00E58C285E4165A" modified="2020-12-02" version="1">MAIKEKVFWIAIPMFISAVLLTIAVIAIAIYFQKLRKTIEAEIKAETQKVDKKTVKRRRKENKYSKSKKGSEDCEPEFYDSPPMRDEHREHLQLKTFQKQIRNEDDYNQCLSQTSSRDHITQLAASRKVSRHAETMPRTLMKQDSYIEFIGDEVALQTMETFQSTKVASKGEHATQAQLKYKSHATSLGRAGIGNECNRSVEPNTRSSNLRGATLPHTSSPIKKDPGYGFKGAFRDIVPQQQVSRKTNPTSKNGHDDREMCEVMENNSEMYENTGYMSDSTEDVYENQEIIEQEDKRRSQNLNMPQVPQHQRNWNSQTVPYHKDNCKMELYENQAIVDQVRKLGHGQHDGDHFELYENYIHEEMYENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM60</accession>
    <name>A0A6P8IM60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cellular tumor antigen p53-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116302703</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567919.1">
        <property type="nucleotide sequence ID" value="XM_031712059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM60"/>
    <dbReference type="GeneID" id="116302703"/>
    <dbReference type="KEGG" id="aten:116302703"/>
    <dbReference type="InParanoid" id="A0A6P8IM60"/>
    <dbReference type="OrthoDB" id="5915660at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08367">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF16">
        <property type="entry name" value="P53 PROTEIN LONG FORM VARIANT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="p53 DNA-binding" evidence="14">
        <location>
            <begin position="132"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031567919.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="57866" checksum="310F4DAF8659755C" modified="2020-12-02" version="1">MAPKLRARISKAMSEIAETLTLRYSDGISKRRRRSSRNSSKNLKVSGRTVLRSGAKSLITSGKQGIRRIEIGEATQLNPIDSFQAQDFPSFPNIDDQEYPEPLTPESPRFPQELNCLMPSAPPSHIVSPSSAEINGEYNFCLALETQPKKVANPDWIYSNIQNKLYIKPQTPCPMKFSLTGSPPPRTYIRAMPIFKLPEHAKDIVRCCPNHTLMDQITRDNPASGHFIRSDNPQAEYQQCVHSGRQSVRIPFKVNVGVAGNEEVTVHELFSFVCNNSCGGLNRRAIQVAFTLETGESNEMLGRCSIEVRVCACPGRDSKQDNEAVSRPSRKKRKLTAADVSSSTPLPAFPPIDLTPTPSRSAEDNTVYNLKVCGYVNYLILRKIAFALEFFANMKSRFSTLPCEDPEFTEFFGDGSAEPRECNGCDTNTPLPRPIPQSSPVMNGQQSLPSCAASHAPDNWYQSPQQEPSVNGRSTATPYMGCYTYRRITLSVEYSETESMCASENKDLMERKDLGVRIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INZ4</accession>
    <name>A0A6P8INZ4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568751.1">
        <property type="nucleotide sequence ID" value="XM_031712891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INZ4"/>
    <dbReference type="FunCoup" id="A0A6P8INZ4">
        <property type="interactions" value="2209"/>
    </dbReference>
    <dbReference type="GeneID" id="116303363"/>
    <dbReference type="KEGG" id="aten:116303363"/>
    <dbReference type="InParanoid" id="A0A6P8INZ4"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="2">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568751.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="87076" checksum="A1BFB6B4FDE4812B" modified="2020-12-02" version="1">MLEQGSTETDINSKIGDELVEDLNVDPEKDSDHFMTLLIESLALLGKIPEAIEAIKGRMKMEMSLIVHRATSQVIERAGREGEPIAQQNQPHLLLELFEVIFDKFRGVAHAHSVILAAIERLIGMGKDREATDLEETNVYKIDAVWYEIQFALQVLLNDYLDYLDVENIVSSKQTSATFSDSDSDISVFFLPRRRGASRNELRTPLFRFECSSSAISMNTYIRERRQECMAGTGVSAMDDGYGEQLHNTKPELVCRPDPRNITVVFSPIMEFVKEIEQVISVQPGMKCTLYGFITDYVKDIFVEKIKFEITEKLEAVSHSQSKGVDAFKHLADANTLKTLGAARPLLQSTVTLYHLMQDLKNLMHNLPQYSSQFLEMICKTLTNYKENCHSTYKELLRYSGDRDKPTKIISGTWAKDEDISRLLRSLPNWTNLQQQHHRQRKEEEEDLEAIKIRNARGSEILTSNLGEHILSKSEVLLDVGDLKTLANLQESMEWFGNHIRLFSTGLSAQSTSISIVTSETQERIKALNPHQKEVYCRSGFMFLQGKNWQEIPPVTDEILKSLTSLAEDFQQLAETCILVLHLEIRCHCFYYLMPAVRMSSYVCNMDAVDPDPSVIALNKDLTSLEEIATACLAQHKFRYLFEGLGHLVSSILISNLAFIKKINQNGIKKMCRNIFALQQNLTNITLSREGDLDKARQYYELLYLNQDGVLTLIVEQGAKYTELEYTNILQLQARSMTVRDNPALEQRLKRLKDIVKEPTNATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP74</accession>
    <name>A0A6P8IP74_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116302904</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116302904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568173.1">
        <property type="nucleotide sequence ID" value="XM_031712313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302904"/>
    <dbReference type="KEGG" id="aten:116302904"/>
    <dbReference type="InParanoid" id="A0A6P8IP74"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028358762" evidence="8">
        <location>
            <begin position="22"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="141"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="472"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="885"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1523"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1642"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1708"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1815"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="885"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1209"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1262"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1317"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1378"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1402"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1544"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1575"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1604"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1642"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1664"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1735"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1757"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1777"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1817"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1834"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1856"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1895"/>
            <end position="1908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031568173.1"/>
        </source>
    </evidence>
    <sequence length="1925" mass="215565" checksum="A851E6B4BC600998" modified="2020-12-02" version="1">MMDRSVGMFLLAVFAIKTAFATPDCLEPDTRVVGRWKNGNYYKGVVESLTNSLNVLFDNGNRLSYNLHSKYDVIEDRIPELHEIKWGDAVVVNRPHSFAFQPAHIREIVGGRYMVWYKDGSYIYQTKNDIRVFNKSAVCNEPAYLGCYRDQVPRYLTAFIPTRPATIASCVDMCNAQGYSIAALRNSDLCFCGNAYNKGYQTSDRRCDMPCYDNPYEKCGGVDVFSQYWTGIVGDKPVYRPSGLEAYTKFHLDPYGFQKTYQSVITKQSIPRFGMLPWRNILQARKAVNKPSSLAHSSPWRWNVLRSSWVRADGKQYRWTHHPALASKNAYRTWSSSQIPLTRNGWTWNGRAWVSGAKASTGLGLQQSPYHYLTRTNPFSRSTYSKPKSKPTYNKGYLHKTVKPKLTELRSYNTWRPQSVNILKSYSNVDISKDFTPNLVLQKLADRMRTVKWSQLSNFGQAFKPSSSIPLPFRYLGCFADDYQRDLPFQYSMPASSLSVRSCVLKCREHSFSVAGIQGSTQCFCGNTYSKYGRVREEECMMKCGSSRTDNCGGILRNSVYFTGIGSAWPHRKGIAANQSKKKTSNASSTHAQYKANDKSARKVTSALHAKFGKTTISSKTKVTKTVQQDSKLQPKKKERGKTQRNKNKARNKLNVIPEQLSEKFNSKIDDFQVESIKVKVNFSELKKALQTLSPEIVRRVQKDLSRMHKKEHKNHTREKVNVELEETQQSNNEEYDENDVERIRNEIHNKALNRLTNQNIKEILRILKIPKAELKDEDSGKNFEDAIKSIHAARKKGMARNGIKAVNGKDFAHEEIESYSRIFFDFPLKPTKEVSKPSTRKKAGIDMKKQKDHLNKKMKIKAQKKNTKDKSTTSIKVKPLRKVYSKEKHPTKMNANEKKINKDANQVTNTKPRKGGHLKENTSAKSTGSKEAQRLEVQSHKPSLKAKFSKLKTVAKTSDGSTERNKGKKTLSRTTKTGLPEKTVKESKMSSNDKPAIGGGNKKVKANNGVQNVVEVGTQPGVAAMKNAHSGDGDLKALLKMPPERKQISKGGDVKNAEGVKSVETGSTNRISRITKSSSKANSAAFPQLNQNKVKITHILPEQVGKDKGEKGQSSAKGSKESHEDKQNTANKLPENNDEKVKKSLSQSQANYNGVIELDGRAKQNDDEKSQNKTSEQKDNLKVNVENEGDENGVIFLGAAANQLQKSKKNDETTKDEQNIPDSKKVKKLKLVKETETENMSPGVSAAQKKEKKMKDDKNKTSMTKTSSDSGNDKKEQKEANTTTKQKAKNNLKKETKIKKKHKQDDSKKEQHKTKVLNDKNDKMSSKESEQKLTTGKKLKILNLNGVADLDPGKKDVGQSDKVLVAPNSVQMKKQRKLEASDSHPAEKQNDAALWDGGSGADTSGSNSDAPQTSFEQENKLLSFQKQNTIYGKSSNSALQKGSMSRGNSLEKVSSTKGKNEDGSQPDYSGMTEAEKTTESKIITKLNNLLNSGSGDDNFENVVNELEKNKIDGISGNGVTIMMGQGSGTNSSQENDEPGPQYSGRSSSMDGKTVQSGEEMMNRKMGRNPIGEDQNGNVGQATLDSNNKETRNLPTKAVGLNNEVDSGSGLENMNNSGELNSKYAYFGSGANKEELPLIRADDLKRLTQEQRRHSFENSGENPQPKKDLQGEPNGKEEKAKLHPNWTKQRLFVKSSIPKPPIYKMILIPRQSMSTNKKNGSKKVDGKLRNSNVILKKKASSKIKSRHGMFNSAKMVGQEKKKQLDQRKLVEGESRYQRGKKRSSISNKVKKTTRKGKYYSDVKGVRVVKNGVSFTVSKSPESPSQSSRLEKGKSNLTNGSSRNLGAPTNNSYLKNNKLKLHHISERRKKFPKKTAKISKTQSNKMAAGENEVSDDSQPNLKDNGSRNQLIWRGSRLNELNRKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP88</accession>
    <name>A0A6P8IP88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303452 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568851.1">
        <property type="nucleotide sequence ID" value="XM_031712991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP88"/>
    <dbReference type="GeneID" id="116303452"/>
    <dbReference type="KEGG" id="aten:116303452"/>
    <dbReference type="InParanoid" id="A0A6P8IP88"/>
    <dbReference type="OrthoDB" id="5968111at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568851.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30216" checksum="9113F29C2B13372C" modified="2020-12-02" version="1">MDQNDAETPQHCMACNRLIYDAAASCKCGHVNEAMRTIAGKRFSGYREELYTRRVIKESRDEYRRMKRESLGTRKRKRKSSTPEKLRLRRQRKKQDDMCTITSDSHDQLNDGLDCDNLTHMTSYTNGNHDNHTQIHLQDITADESNKTHDLLEIRDDLENDVHIDSSIGHVNECPSYKQYLPTTKTISHKRGPKKTTFNQFNRKTRDGCRENKTRIIRPMKQFAIAGPLAEINKRLMNQSGFWMCLGDSLGLSKPAAADVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP98</accession>
    <name>A0A6P8IP98_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116303299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568677.1">
        <property type="nucleotide sequence ID" value="XM_031712817.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IP98">
        <property type="interactions" value="1294"/>
    </dbReference>
    <dbReference type="GeneID" id="116303299"/>
    <dbReference type="KEGG" id="aten:116303299"/>
    <dbReference type="InParanoid" id="A0A6P8IP98"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0711">Selenium</keyword>
    <keyword evidence="3 8" id="KW-0712">Selenocysteine</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031568677.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23369" checksum="DA5BB30F6D0E56A0" modified="2020-12-02" version="1">MGSLLHRRVFQANKYLFSPSTFNNLRIVCLPVGLAAGLFSTAMAEGGKAATSICEFEAKDIDGNDVSLSKYKGFVTLIVNVASKUGFTKKNYTQLQELHTRYAEKGLRILAFPCNQFGSQEPGINEEIKEFAKGYNAEFDMFSKINVNGSDAHPLYVFLKKAKKGTLTDNIKWNFTKFLCDKEGIPVKRYAPNTAPLDIVKDIEKELNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPY7</accession>
    <name>A0A6P8IPY7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Allatostatin-A receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568515.1">
        <property type="nucleotide sequence ID" value="XM_031712655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPY7"/>
    <dbReference type="GeneID" id="116303162"/>
    <dbReference type="KEGG" id="aten:116303162"/>
    <dbReference type="InParanoid" id="A0A6P8IPY7"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="67"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568515.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45947" checksum="82341550BE424E29" modified="2020-12-02" version="1">MDKSKKVEFNISFHRMDTKSLLSGDTLEPFLNQSSGNLTEDKKANLDNVNVFQVVILSLILIAGFVGNILVVGVVALKCEMRTRTNIFFTNLAIAEIGTCVFCVPLMLMGLTRGRWNWGNEFCKVNCFMLQFWFLECVFTLIALSLHKYLSVYKPLKRIMNRKRTFLVILCTWMIAFLCATGPVLGWKKISNQSEAATCYFNNPTRTLHFAHVIFFSTISYMIPIIAIIIIYYNVIRVVQKHFKRIRDTGIIDDKGIRAKRRIVITISIVIFVFFLCWTPFFVNSVMSLLNVQRDFFRVALFCGFSFSVFSPVILVMRNPRFKRGFGEILTCGFFREGSQIDLGTSFGSNISHTNPSFEYIEERRCSAWYMSTQKNLLSLEPAPPERRLKLRWIETNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRE4</accession>
    <name>A0A6P8IRE4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568833.1">
        <property type="nucleotide sequence ID" value="XM_031712973.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303442"/>
    <dbReference type="KEGG" id="aten:116303442"/>
    <dbReference type="InParanoid" id="A0A6P8IRE4"/>
    <dbReference type="OrthoDB" id="6088715at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568833.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="79783" checksum="D4BAC2D934E03B5F" modified="2020-12-02" version="1">MSKSSPIYISDDSEDEKEKNCSDRVFEEVFSEDDNSMPGSCVFKHFSPLTPVKVKREAEETTPTKSPLNVSPKIKITVDKDRLKWLSGVIKLASVSPVKYESSTCEGVCTATSKAVKHLEMPDIEDHLLQPSSSYRVPQETEKEDHKDHLQLSSKSTNEESLPSLPWSHSPLSYKNSPDKPTFSSRTPKKSNLQKAIESPRKVGIFGSPQKPLKQMFIXEEVFSPKKSMGSPSEKIEDTSHHTPPLHACHFNGYVSVHKLERPVFPFSEFQLIVLEGIKEEGLVAKYIDTLISYVSKYRKPPPEICFYLLSEVLLKSDSISLATKCFWALKRIQALHPSVPEQMEKTCITWETIEMIVERMELTGCRCKKSEDSNDQPCIRSFSAFKALAFLINIMESEAVRKQFCLRRTIAFRLLSVQRISSRNVNQVVWWIKELCMATSHCKKKDPTAESKVFETITDHDACIHKKENYLYQAIDLFQRLIQLSLSVSEDPESCATKLVGELLFAYNQLEHLECRTIFLQSIHSHLLRSKFLEKYLEVYCKDTEANRNISHYSGIQKIVQVDFERLPPKRDYLTEETSEARKCHEWHRGREDCEEMSMVLSYSLQSYLFSHHKKLQCSPKRIPLTSKVEEESNKKQANSHHLSITDVDEICNMGDKVVIMAGRLMSLCPEASLNARTNHLIELLSDMKLWDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU61</accession>
    <name>A0A6P8IU61_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit beta-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569728.1">
        <property type="nucleotide sequence ID" value="XM_031713868.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116304178"/>
    <dbReference type="InParanoid" id="A0A6P8IU61"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000031">
        <property type="entry name" value="Cholinergic receptor nicotinic beta 1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569728.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="30661" checksum="4A42BA7793781C1B" modified="2020-12-02" version="1">MDENIWEPDVVLLNNADPSTMGKPVNHGNPLLITSNGTVRWLAPVIIKSSCKLNVRYFPFDXQVCDLEFTTLTSDHSEVFLQPSRDKIFQDYSESSEWILRGAHIQQTTPPLLSNDTRTGVKYMIYIERQVFYYFFYLVSPCMLVSLMTIIXFILPPDCGELMVVGVTLLLSLTVFFLLASTHIPETSEVVPLIGRLPKKVSGLSMMVDQVKKKQENHQKQEEWQLVAKVFNRLFIVIYIITVILTLAGIFXQIPQMLGRSEVHTDISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU87</accession>
    <name>A0A6P8IU87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569753.1">
        <property type="nucleotide sequence ID" value="XM_031713893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IU87"/>
    <dbReference type="GeneID" id="116304200"/>
    <dbReference type="KEGG" id="aten:116304200"/>
    <dbReference type="InParanoid" id="A0A6P8IU87"/>
    <dbReference type="OrthoDB" id="10524760at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569753.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18985" checksum="251B0B3073C7E905" modified="2020-12-02" version="1">MKDYHVDDRDNELFTTSPEWYYSNTINKTRIAADAKTYVSGRFEWRWYLAPSCPARLRHRLGKESVATLVISNVTTRDNGKYSCSLVLRGGKKPIKSATQLVVTVSISSPGPLTREVGQDVVFMINATNIVGVNWGIRDGNTNKLQQGLINYNKADGIQLDKKINSTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV54</accession>
    <name>A0A6P8IV54_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neurogenic locus notch homolog protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570040.1">
        <property type="nucleotide sequence ID" value="XM_031714180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304442"/>
    <dbReference type="KEGG" id="aten:116304442"/>
    <dbReference type="InParanoid" id="A0A6P8IV54"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="19"/>
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        <property type="entry name" value="FAT atypical cadherin 4"/>
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        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neurogenic locus notch protein 2"/>
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    </dbReference>
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        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
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        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="25"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
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    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="15"/>
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        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="24"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027748456" evidence="9">
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    <sequence length="2059" mass="226824" checksum="34D56C3DB151B954" modified="2020-12-02" version="1">MLLAPGTCLTLVWLLVLLLVDSTQSMKGQPIDTHKPNFNHPHGNKTSAKQVKKSTKGSQDPRTKRSPQFNPGFNGLGRPTQIGLGQLGLSLNPRLPALGLQGTPAFGQYRSLIPQTNPLIANNAGYRLPYNYQLARLLSTINLLRERSDLASAVNPAAATGFGLYKPKRLKYNSIPLKPNDLDGNALSLLLGRNSLNSQPENDDDDDEDSDNNGFCSPNPCHNGGKCKNHLFGFKCSCVNGYTGKRCAGKNPCHPNPCEYDGECTISGTSFECSCPPGRKGEKCEVEDRCHPNPCMNGGTCTELSDGHECTCVHGYRGRNCEVRSGSCSTNPCQNDGNCIETPSGFECICKAGYSGTLCSASQNKCLMNPCLNGGKCFQTLSGTGFQCDCPSGYKGDICEDMSPCHSGTCHNGGTCYETDSGYKCICRQGFGGRNCDVHHSCQMDTCKNGARCIEHENGFKCVCSSGYRGLYCEETDRCKPNPCXHDGECIETENSYKCKCQNQFKGAHCEDMDLCATNPCMNGGQCFGYDGGFKCMCQQGYKGDTCQVKNSCEPNPCHNDGECTQDGDKFKCSCRRGYSGDHCELVDSCLSNPCQNGGKCSSLADGFTCSCSPEYKGKYCHEKEPCHPNPCENNGKCLSTSDGFICRCSLGFKGETCSEEDECQPNPCQNGGRCIGRYIGGGFDCACSEGFRGTTCKEKDPCHPNPCNNNGFCNEIGDGITCNCSQGFKGSTCSELDRCRPNPCHHGGMCTEVVGGQGFVCRCPQSYKGLTCEAKDRCHPNPCLHDGYCLEINNDLGFLCNCSTGYRGSHCQDQDPCHPNPCNAGKCLHTSDGSFACNCNIGFKGSHCQDKDLCQPNPCQFSDKCKQTSADSYQCVKNVCDPNPCLHGGRCIEVNDDDFQCVCSNEYKGKTCDVLAEMGESRHKVPDNKNVPSTNDFCHPNPCKNDGICTSHETGFHCHCKNDFTGARCEEKKDILTTQNDYCSPSPCKNSGVCVQEGQGYRCACKAGFTGFHCQVDPCQSNPCNDNGKCIRDKKADTGYRCRCLHGFVGKNCDENYCLPNPCSNNGICVSIPDKGYQCKCRDGFTGARCERSPCSPNPCKNGGTCLVFYTVYLCKCPKDYRGTQCEASLANRPAAHVVAAQDITATRKAETSKPSDHALPSSHILNKTSGCKPDPCKNNAVCLDTIDGGYECFCRGDYSGSKCEDIGVYTYSSAPKFFPGKGEECKHCDRYAHCVAGHCICKNGYVGDGLDCWEETLEDREWTCEVNPCQNGGTCKPGISKCVCRLGYIGKYCEEDCSPSIHLSFDKVSASTLLDDSGDSNNAMIVNGAQIAPHSGKCGNAVNLLGGDILMDGSHFKHIPREGITISIWIKLETKLGVQSIFDTVGSHSRHKDGQYHLEVDNGRVRWFHRDENRQTIFSVLSKPAVSEGRWTQLTVTYSANKQRARVFVDGDMITEEGGHGLLSQDWSGKVGIGKHQHIFGNRLLRGMVDEFYIFPGELPRLEILVLMRHCKVYFSNFKNKKQKDTKQVPQLSFSPNAPVINSYAPPIGGKPLSPSNQEANNDKVANNLEEILDSFEEDKPVVPQRSALSPSYQIQKQQRPLPMEWGNQRQYQGTVQPNRYLLNRYHGFVPSQTQPFFNRGRKIPQYQTGARQDALQRPVGKQTMFNNPQAGNPALRKVSVNKGYRFEQYGSQRHPAFNQMQIPLSYSINPPRQVPHGRASSTAQMRGPLTYMNGLLAPARPVPDTNFEVSSTKTRIPVNQLSPYARRRQYLSQYNPPSRTMKTATGVLHSWLNSATPDLNRTPLRSSVYPKINYPQKGWYKSSQTVPRQSMQPFNPRGSTNYLAYNRRYPNLRPQRPAALPRPAQSYRGAPSPYKVSYTNYDRKXDGNYANDKPQSSVYDYTHVRGNPRTMNNRENTGLDKNSLSLTGRRPSLQKNNNKQNYATDLQGSLDSLKQSGLIRKVDPSKYLAFKLTPQFTSDPNKMYSNALVQLNSQLRQLMDDHTVDFKPEQLHFVMGLLQKGLDQMEQSVEGKQGKIITVPTVNPKGVPTDPSKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYA5</accession>
    <name>A0A6P8IYA5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">E3 ubiquitin-protein ligase TRIM71-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116305123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570820.1">
        <property type="nucleotide sequence ID" value="XM_031714960.1"/>
    </dbReference>
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        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="GeneID" id="116305123"/>
    <dbReference type="KEGG" id="aten:116305123"/>
    <dbReference type="InParanoid" id="A0A6P8IYA5"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14954">
        <property type="entry name" value="NHL_TRIM71_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF57">
        <property type="entry name" value="BEE-MILK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17170">
        <property type="entry name" value="DUF5128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
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    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
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    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
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        <property type="entry name" value="NHL repeat"/>
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    <dbReference type="SUPFAM" id="SSF57850">
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    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
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        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="ZF_BBOX"/>
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    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="146"/>
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        <location>
            <begin position="160"/>
            <end position="207"/>
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            <end position="463"/>
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            <begin position="617"/>
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        <location>
            <begin position="668"/>
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            <begin position="713"/>
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        <location>
            <begin position="209"/>
            <end position="236"/>
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            <dbReference type="ARBA" id="ARBA00008518"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031570820.1"/>
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    <sequence length="754" mass="84941" checksum="72728D3DFE53077A" modified="2020-12-02" version="1">MTSVVHVLEQINEQLICAICLERLCKPRVLDCMHSFCTGCLQRIANNDSSSTITCPTCRMVTPIPESGIEQMKANFFINQLLELVKNKGDELKKEIRETKKCETCEDDSPDFATSRCVDCSKDLCTSCVAEHKRAHDTLDHRIINTIEGEDNEDQELDRYSLSFCKHHTRNVIKYFCITCDEAICRVCTILEHREHQYVYPKEALPLRRTDIQESLEKAKERIPQLKKTMSEVDEMSRRLHECHQTLAREIHHNTQVRIKALMEAEQKLLKQLSDVNISKQKVLGLQKDSIELEIGKLTGCCEFADNVMVFGNEVEILQMKGRLESLNNLKVKLEPEEDDTVEYICDXSNIKTVIESVGKIHASSTFASISFATGEGIHTARVKIETHFKLYTKDRRGARSIGGDRVFIQLTQPDGSELPCRVEDKGDGTYMVYYTPEVNGHHQASVMIQDKPIMDSPFTILVVNRREYKEIGPTLMRIGQYGSKKREFKSPFGVAVDSDGRIYVADSYNHRIQVLGSKGEYVTSFGSHGDRKGEFNCPTDVAVDQKGRIIVCDNGNNRIQVLNRNGGFIGKFGREGIGNGYFKSPWGVAVTQRNEILVADMENHRVQMFSSEGKFMFKFGSLGDRPGQLSAPCYLLISNDDDEILVSDSKNHRIQVFDMNGKYLRHFGTHGSGEGQFTHPRGIAIDIAGNIIVADMGNHRLQILDSKGNFCKEVGTEGNGDAGQLSFPESVAIMPNSGYIVVSDLSNNRIYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZL1</accession>
    <name>A0A6P8IZL1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain-amino-acid aminotransferase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116306987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572981.1">
        <property type="nucleotide sequence ID" value="XM_031717121.1"/>
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    <dbReference type="GeneID" id="116306987"/>
    <dbReference type="KEGG" id="aten:116306987"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031572981.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29257" checksum="D95DE7B13750D8F7" modified="2020-12-02" version="1">MKAKRVFLWSAPRCVSTAFERSMRTLRDVQVFHETFAIPFHHGPERDSDLFTDIPLDPSATYQSVADTLKQEYQGKQLVFAKEMACCLKKHYDILLEDGMREFQQTFLIRNPHDVARSLINCGYFVAKEFGFKELYELYQFVVDNLQPSPVILDAGELLEYPDETMRAYCGAIGIKYEVGMTTWQPGPVPGWDREVCAGWHDSVMNSSGFVKRSRKTEAHKKDDLPEEAIRVVEECMPCYEAMYAKRIVPKTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZZ0</accession>
    <name>A0A6P8IZZ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Octopamine receptor Oamb-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116307103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573111.1">
        <property type="nucleotide sequence ID" value="XM_031717251.1"/>
    </dbReference>
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        <property type="interactions" value="2156"/>
    </dbReference>
    <dbReference type="GeneID" id="116307103"/>
    <dbReference type="KEGG" id="aten:116307103"/>
    <dbReference type="InParanoid" id="A0A6P8IZZ0"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031573111.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41389" checksum="BCABB8D8FF41E6E1" modified="2020-12-02" version="1">MGDLNQTFPNNSGGSSCSMKASQADRDGKIAGYSLILIISLLGNILVILVVYKNRNMRKTINFFIVNMAASDLIIPLVVMPMQISRTVYGHWIVDAPAREVLCKITFFLSELPGLVSVLSLICMAIDRFVGVVFPLRAGLISSKVRIAMIVATWVISLGFSITSFYTMRVVIGRNGKPHCIMRWHDDIEKHMVALKTYSTILSVVFFVTPLILLVLFYSVILITLGKRKFPRVNQSQEAKKRNRRVSRSATVIAFTIVMVFWICWCPYNTIMFLWAFKWDWNFPTFCSFRTIFVICQFLTWANAAVNPCIYFVLIDNYRKGLRTVFPRTLSASLNSSLKMAGRSAARHDTQQVNDEGDCLELVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0M8</accession>
    <name>A0A6P8J0M8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573406.1">
        <property type="nucleotide sequence ID" value="XM_031717546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0M8"/>
    <dbReference type="GeneID" id="116307352"/>
    <dbReference type="KEGG" id="aten:116307352"/>
    <dbReference type="InParanoid" id="A0A6P8J0M8"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573406.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="63699" checksum="8F874C6C9F662A31" modified="2020-12-02" version="1">MGTGVCFEYEDNDGPSTILKQMNVFRQDSSFCDVVLSTDDGMDFKAHRVVLASVSEYFRAMFLSEMRESQLDRITIKEVDSKSLGQLIDFAYTSKTNINSANVEMILSAASMLQFIKVENVCYEFLRKNINVPNSLAIWNLADLHGSTELSILAEGFIRGNFTSVFKHSDFVTLSHKQLIRLLGHDKLNITSESAVFEAVMTWVRHDLETRETYLAELLEQVRFPLLTRKFLIDTAAKENLIMNDPLCRNYVLEAIDYHLIPERRDKNKTPRTIPREKSSRAVYVVGGEEQGTVLNTVECFDFNDKRWSFVAPMIIARKQVGSAVLDGQLYAVGGVNNDYADLVTVECYSPCTGQWTSVASLNKCKGSLAVVILEGWLYAAGGSHNGSALKTVERYDPIQNEWTQVASMRLPRSHFGLTALQGRLYAVGGYCGISEIEHVECYDPMANKWADVNGLNKARMSHSVVTYGERIYVIGGSNSVGVLDSIEKYNPDLNLWLIIRNTMEPRSGAAVAAVYGGDEAVQDLYIIGGQDYHKRTINSVKKLNLKFADYSTATAPPLIFSRAFAGVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0S4</accession>
    <name>A0A6P8J0S4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Homeobox protein otx5-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16 17 18 19 20 21" type="primary">LOC116307357</name>
    </gene>
    <organism evidence="11 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573416.1">
        <property type="nucleotide sequence ID" value="XM_031717556.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573422.1">
        <property type="nucleotide sequence ID" value="XM_031717562.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573433.1">
        <property type="nucleotide sequence ID" value="XM_031717573.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573444.1">
        <property type="nucleotide sequence ID" value="XM_031717584.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573454.1">
        <property type="nucleotide sequence ID" value="XM_031717594.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573462.1">
        <property type="nucleotide sequence ID" value="XM_031717602.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573471.1">
        <property type="nucleotide sequence ID" value="XM_031717611.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573479.1">
        <property type="nucleotide sequence ID" value="XM_031717619.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573489.1">
        <property type="nucleotide sequence ID" value="XM_031717629.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573498.1">
        <property type="nucleotide sequence ID" value="XM_031717638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0S4"/>
    <dbReference type="GeneID" id="116307357"/>
    <dbReference type="KEGG" id="aten:116307357"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000068">
        <property type="entry name" value="Orthodenticle homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031573416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031573422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031573433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031573444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031573454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031573462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031573471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031573479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031573489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031573498.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22600" checksum="26FE745B3A596E62" modified="2020-12-02" version="1">MAGFLNNYPGCPLGGLNLPPRSAADMFNPMVAGPSYGYPRKQRRERTTFTKNQLEILEELFSKTRYPDIFMREDVAMKINLPESRVQVWFKNRRAKARQQTKGEQKPKPKPKSPPITKDLQQPIPPPPCRYASCSGNIWSPAHESVRPSLSNFPSHSVMNNGMSTSNSGAFMPPPQAPPYFCSPPSGPYMSLEHMHPMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J117</accession>
    <name>A0A6P8J117_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase DDX51-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573601.1">
        <property type="nucleotide sequence ID" value="XM_031717741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J117"/>
    <dbReference type="FunCoup" id="A0A6P8J117">
        <property type="interactions" value="2887"/>
    </dbReference>
    <dbReference type="GeneID" id="116307474"/>
    <dbReference type="KEGG" id="aten:116307474"/>
    <dbReference type="InParanoid" id="A0A6P8J117"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="271"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="403"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573601.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="72661" checksum="9BD5CC8A6199B0FB" modified="2020-12-02" version="1">MELFVVKRYMGDGELTPNSKDDEAERLSLLKKHIEKRKRKLAIETKDMYEKDGKITKESNETEDVKFAKERERKAKVLLETKEKDMPTSNEEFEEAREKKKKKKRKKTKVNTCTSDAKEEDKPEMAEEKDINEITELKKKKKKNTEVEEKIEIPENVSGISENLKDSTEEIPKEICDSEVSKTDLGFTVIGQKRRNKDIKKVEKSLPDWLAKPQVVDTDLNSNLLPVDELDVLSKQIKNRLQELKITSLFPIQKAVIPTILNQIQKGSLYGIGGYRPSDICVSAPTGSGKTLAYVIPIVQALSTQTVCLLQALVLLPTKDLAFQVKQVFEAFVKGTGLKVGLASGNKALAKEQESLIGQGYGSFSHVNILVATPGRLVDHLSYTRHFTLQHLRFLVIDEADRLLDQSYHDWLNKVLKASYVNHSERQDSIGSLCNGYRRSSHLENSNPTPWGRFGYFLLITFACYLYDRLCLLIKLFGGIEVAEYSSNLNAQQRHGILRDFKSGSIHLLICSDAMARGMDIDNVSYVISYDAPKFVKTYIHRVGRTARGGNEGTAFTLLHNDQVHHFKELIQKTGRDKIPKQTFKDEEIQPLVEKYQNALKKLEETVKNEKQEQGGHKTRGQDEAEKYLQEQLLANIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J143</accession>
    <name>A0A6P8J143_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">QRFP-like peptide receptor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16" type="primary">LOC116305979</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571851.1">
        <property type="nucleotide sequence ID" value="XM_031715991.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_031715993.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571854.1">
        <property type="nucleotide sequence ID" value="XM_031715994.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571855.1">
        <property type="nucleotide sequence ID" value="XM_031715995.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_031715996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J143"/>
    <dbReference type="GeneID" id="116305979"/>
    <dbReference type="KEGG" id="aten:116305979"/>
    <dbReference type="OrthoDB" id="5963239at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031571853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031571854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031571855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031571856.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39994" checksum="45E827DCDB332096" modified="2020-12-02" version="1">MSIYANSPSARITVLTILSLFVVADVFGNILVCLVVLRNPSMRTAMNLILVNLALCDITVAIGMTSKYILTELISHPTGDFGKYLCTFITSGNLTWVGGLASVFCLVSLSYERYSAIVNPYDIHKRITKRKAVWFSVASWIMSMIICVPEFIGYDYYITRQGCFQKWPFPWLPKAYSMFWLFVVGIIPISLMVFFYSRIVHTLWFQSKRDPELAQQAALRYRKSVTKMLIVISVIYIIGWMPTLCVFVLVFWSKAFQVGQVIGAVTAILVVFNSAVNPYAYALQSKEFRKRLKSYIFCCQCRLVVLPVNDTYTQHSVALNQPHVNKAFVADQNIELQSYNKRSQTCLKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1D9</accession>
    <name>A0A6P8J1D9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 84-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116307275</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573299.1">
        <property type="nucleotide sequence ID" value="XM_031717439.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116307275"/>
    <dbReference type="InParanoid" id="A0A6P8J1D9"/>
    <dbReference type="OrthoDB" id="5972065at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000290">
        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="14">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031573299.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42901" checksum="206ED2561801BCF7" modified="2020-12-02" version="1">MYVDNERQMENRDSESNEIREDVNDDDTIDVNEQNTFNNTDVNXNLDEVSEDYEVDESLSTIVTKMKERKELVPNVQTKHKSNTKTYACSYCSRTFKWKSVLDIHLRTHTGEKPYRCLHCEKAFTLKSSLVIHLRIHTGEKPYECSYCDKAFSTKTRLKTHVRTHTGEKPYECSYCDKAFSHSFSLNRHHLRSHPGEMPFECSYCDKAFISKTKLKIHVRTHTGEKPYEGSYCDKAFSATTRLRIHLRTHTGEKPLKCSYCDKAFITKAKLDIHVRTHTGEKPYECLYCDKAFARKENMNSHLRTHTGEKPFNCSYCDKAFAQKTYMNSHLRTHTGEKPFNCLYCDKAFSQKTYMNSHLRTHTGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1Q0</accession>
    <name>A0A6P8J1Q0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glucose 1,6-bisphosphate synthase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116307410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573517.1">
        <property type="nucleotide sequence ID" value="XM_031717657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1Q0"/>
    <dbReference type="FunCoup" id="A0A6P8J1Q0">
        <property type="interactions" value="1553"/>
    </dbReference>
    <dbReference type="GeneID" id="116307410"/>
    <dbReference type="KEGG" id="aten:116307410"/>
    <dbReference type="InParanoid" id="A0A6P8J1Q0"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000017">
        <property type="entry name" value="glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="57"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="223"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="365"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031573517.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="67686" checksum="A1C0FF2BD5865090" modified="2020-12-02" version="1">MAEENLTNINTGDSQLDQKIQEWMALDKHPKTLEEVRNLIKEKNFDELKVRMLSNLSFGTAGLRSSMGAGFSKFNDLTVIQATQGIAKYILKTFSDAKERGVVIGFDARHNSERLSQRAAAVFLSQGIKVYLFNKITPTPFVPFGVTYYRAACGVMITASHNPKDDNGYKVYNENGAQLTSPYDKAVSQCIKENSIPWDESWDLELSKYKELLINPYDEVFAAYFEALKKYSHFGNLNEQTKITFTFTPMHGVGQIFAVKAFEVFKLPPFVSVIEQMNPDPDFPTVKYPNPEEGKSALDLAMKAADANGSTVIIANDPDSDRTAIAEKQSNGKWKVLTGNETGALLGWWAFFCHKKDHPQLYPGDNVYMIASTVSSKFLDSMAKVEGFKFDETLTGFKWMGNQAHSRMQQGKTVLFAYEEAIGFMYGTNVLDKDGVSAGVVLAEMATYLNTQGLTLTQQLSKLYESYGVHISINSYYLCMSPPVITNIFNRIRTLENGQYPLSCGGFKISGIRDLTTGYDSTKPDNKAVLPTSKSSQMITFYFENGCVATLRTSGTEPKIKYYTEITGRPGEKVDMEAATSTLQKLVNSIVIEFLQPEVNDLIAKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J336</accession>
    <name>A0A6P8J336_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BPTI/Kunitz domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116306526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nematocyst</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572468.1">
        <property type="nucleotide sequence ID" value="XM_031716608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J336"/>
    <dbReference type="FunCoup" id="A0A6P8J336">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="GeneID" id="116306526"/>
    <dbReference type="KEGG" id="aten:116306526"/>
    <dbReference type="InParanoid" id="A0A6P8J336"/>
    <dbReference type="OrthoDB" id="5969998at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042151">
        <property type="term" value="C:nematocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008200">
        <property type="term" value="F:ion channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22616">
        <property type="entry name" value="Kunitz_TFPI2_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000021">
        <property type="entry name" value="Serine protease inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000002">
        <property type="entry name" value="WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF376">
        <property type="entry name" value="SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0166">Nematocyst</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="9">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031572468.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21387" checksum="3F9F4638B8D37829" modified="2020-12-02" version="1">MHFNLFARSNIVASFHILNPIPSEFNPIFSANPTHVPFQSLLDHPSRAYNAITNQCFFLKGLSSSLADCNVYSYSNICLLPKVVGPCEALIPRYYYNSETKQCEKFFYGGCQGNANNFVTLEECEKTCNCGVNICDLPKIIGPCKGYFPRYHYDSKTRACQQFIYGGCNGNANNFLSRDACKKACPSYTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3C4</accession>
    <name>A0A6P8J3C4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116308252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with LYAR and RPL23A. Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574501.1">
        <property type="nucleotide sequence ID" value="XM_031718641.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J3C4">
        <property type="interactions" value="2096"/>
    </dbReference>
    <dbReference type="GeneID" id="116308252"/>
    <dbReference type="KEGG" id="aten:116308252"/>
    <dbReference type="InParanoid" id="A0A6P8J3C4"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="212"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="808"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574501.1"/>
        </source>
    </evidence>
    <sequence length="905" mass="101920" checksum="147707E3587A7DAB" modified="2020-12-02" version="1">MAKTSKRSSAKEAPKTRASSNSSMNPDRPKPSPNSNMRDKSTIMRIKMYKSGGKAIRNSGGKIVKPAPFQTKAISGEVARVAPNRKWFGNTRVITQNALQKFQDEMGRVIQDPYKVVMRNTKLPLSLLDERAKTSRVHILDTETFDSTFGPKAQRKRPNVKASDIQSLAQAATSQLEKYSHENDKDLVKEDDGEKAKAKESIYAKGQSKRIWNELYKVIDSSDVVLQVLDARDPMGTRSKHIEKFMKKEKTHKQLVFILNKCDLVPTWVTQRWVTILSTEYPTLAFHASVTNPFGKGALINILRQFSKLHSDKKQISVGLIGYPNVGKSSIINTLRAKKVCKVAPIAGETKVWQYITLMRRIFLVDCPGVVYPNDDTETDIILKGVVRVENVKEAAEHIPEVLARVKREYISKSYKINTWNDATDFLEQLARRTGKLLKGGEPDVNTVAKMILNDFQRGKIPYFVAPPKQEGDDTNPRPVKEKKTKQKELQIPPLSSSFVKSTGQEHTDKTAEDLNKDASEPDMTNQNSTETTESTDEVKQDENENNNNTKGIEQGKTGSFRVKQDFSTICVAPEFEGEDVKPLDDNGSNDDDDGGDDDEADDDDEADDDEEADDDEEEVDMEGEEDGGDGIEDKDINEDVNKKIEDDADDVGGDSFDGNDAHNNKDNINNTIGHNDADDVSDNTDNILMTTKTKDAKKKPEEKKEPKESVSVIDMTTGQVHSSKEYFDVGEWEELKEAMEQQDDIDSSPDEAESDEESEDNTKDSYQKTEAETTPRPVNSKYWTTPSKKXYSVSMSPFVACVEALEEEEDINPSEVESPKKREHITNTKKTKGSSQVPSKGKTRKRRGEESKEEEKEESPKIKKTRMTTNKKRVGVHYYDTTNVKNKNRNIKDTDTKKNRKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3Z1</accession>
    <name>A0A6P8J3Z1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein Gfi-1b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574362.1">
        <property type="nucleotide sequence ID" value="XM_031718502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3Z1"/>
    <dbReference type="GeneID" id="116308128"/>
    <dbReference type="KEGG" id="aten:116308128"/>
    <dbReference type="InParanoid" id="A0A6P8J3Z1"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000345">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF419">
        <property type="entry name" value="FI21258P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574362.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43187" checksum="781CD46BBA50DB1E" modified="2020-12-02" version="1">MPKAFLVKKRASDGSSREKNQHLNFVPSPKETQRKNDDNKPPPAEEEKPSNRPFDIANLTRPDKPAIKQPVVDADQNWGLHFPNRFMFRDLGSHFRGTGHTSSYQLYDTRRFSPREAYSPCILSPYGRFHNQVCFTSGISELPMPYPCWSPSPFASRLPSSPLSYRENDRSVSALVCPSPLRPALLSPSPSEKKKNDTSLNGGEPFECLNCKKVFSTSHGLEVHVRRSHSGRRPYECTICGKTFGHSVSLEQHQSIHNNEKTFQCKECNKKFKRSSTLSTHMLIHSDTRPFGCNYCPKRFHQKSDMKKHTYIHTGEKPHKCLECGKTFSQSSNLITHSRKHSGFKPFSCQICKRSFYRKVDLRRHMYTHETAPGILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4S6</accession>
    <name>A0A6P8J4S6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Phospholipid phosphatase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116308383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574649.1">
        <property type="nucleotide sequence ID" value="XM_031718789.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574650.1">
        <property type="nucleotide sequence ID" value="XM_031718790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4S6"/>
    <dbReference type="GeneID" id="116308383"/>
    <dbReference type="KEGG" id="aten:116308383"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="116"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574650.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33437" checksum="1AE9A16E00962887" modified="2020-12-02" version="1">MSIRKVHNAYCALDVICFVLVGFANLLLHVTNIQPSKRGFHCDDESITMPFREETISTLTALFVGLALGVLTIIVCEILRHFVFKFKPRGAGRDNFYIKLGPITLKAWQRRILFLIFMFGFGAVVANLFTDAGKLLIGRLRPYFLAVCKPDFSKVNCSAGKFITEDICTGDKKQITEARMSFPSGHSTFSMYCTVFVAMYLETAIPTRKTTLFKPLLQISVIMLGVLCALSRIFDYWHHWGDVLTGMALGTLVATFIVFKPLSLFSSNAATEYDVSVRQPSDVEAVQVQRNSQLSEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4S9</accession>
    <name>A0A6P8J4S9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Somatostatin receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116308717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575056.1">
        <property type="nucleotide sequence ID" value="XM_031719196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4S9"/>
    <dbReference type="GeneID" id="116308717"/>
    <dbReference type="KEGG" id="aten:116308717"/>
    <dbReference type="InParanoid" id="A0A6P8J4S9"/>
    <dbReference type="OrthoDB" id="10320147at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="46"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031575056.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45414" checksum="11060282771AF4F9" modified="2020-12-02" version="1">MDVGANNSVNNSTSFSRKYIFLPFDGRVKTVMFIAMGVLCVYGTAANSLVLYLKKKKRDRLRNPRKPFYRNLLAVFIQNLSGCHILFCSIAFPAQVMLNFIDVTNSNLLCRLSWFLRLLFPIITLNHLLVLAIEIYLSIVYPLVVPSARVAKRLAVATWVAGGLVVLMASATFTWKPQTTGPHSYTLMCLIDKTVFIYKLLVLVFVVINIILPALALIFLTYRIIAFLRNRKNASRVSNLHLQRKVPGNSNARAIVNLLLIFFLPYGLFLFASISRPALKTAQEDFAMQYLLVLVNSVLAYSNAAICPTILLIRLPDLRQSFKYNIKSKFISRKDRVQVPPKSSEISQANVKAVRNSNIVAVSGSQEQFEMAEMSSFRDMRDTRAKKREGKIVWMEQKCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4W9</accession>
    <name>A0A6P8J4W9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 58-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574702.1">
        <property type="nucleotide sequence ID" value="XM_031718842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4W9"/>
    <dbReference type="FunCoup" id="A0A6P8J4W9">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="GeneID" id="116308428"/>
    <dbReference type="KEGG" id="aten:116308428"/>
    <dbReference type="InParanoid" id="A0A6P8J4W9"/>
    <dbReference type="OrthoDB" id="264785at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="4">
        <location>
            <begin position="369"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="830"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="305"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="410"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="648"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="830"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031574702.1"/>
        </source>
    </evidence>
    <sequence length="879" mass="103591" checksum="95B44018C5699729" modified="2020-12-02" version="1">MEGEKKETKEKPAIEENAFEALERDFQEVLGELMGDKSLEKFRVEYEKLHRALKKSHESEKRLMQKCRELNAEIVANAAKVQTALKLSQEDQTTIASLKKEIEKAWKMVDAAHDKEQRARETIQSLKLEIANLSKLVEQGAGLTMGQDHSVNELLKIKDELTKERDEKLSEVTKLRDELSGATAKQQKAEQDREEAEMKIAELKEDIQVRSNEAQREARKKEKIEKELKSSKNELEAKTLELKTKNSQLQRSQEEISKLEQQLKEQRILNEKAMKDTDLLNARLTKVQQDFEQQLMNCDQLASENTQKAAELKAREEEINGLKQDTVKLTKMREAIQRRLRAVEDQKLEVEQQKETLKSQIAGLEKELEISKKQSEQDRKAIDDLVRERDILNKNLLKAAGATQKQLGVVRLHEQTKKNLEQEIQNYKDEAQKQRKIIYQLEKERDRYINEASELTQKVLQHMEDVKVREMQIFDYKKKIAEAETKLKQQQNLYEAVRSDRNLYSKNLIESQDEITEMKRKLKIMNHQIDQLKEEITAKEATLVKEHLEHQRVEKEKDALKAELQRMKQQAAESKAYIEQQEAEERKLLKIISEADSERMRQKKELDQVIGERDILGTQLVRRNDELALLYEKIKIQQSTLNKGEIQYRQRLEDIRLLKLEIKKLRREKNILTKNVANVEDLRREVYHHQRELLRERTRCKALEEELENPMNIHRWRKLEGSDPSTYEMIQKIQTLQRRLIQKTEEVVEKELLIQEKEKLYMELKQILARQPGPEVAEQLSIYQQTLKEKTKQMKGMSSELNMYEAQVKEYKYEIERLAKELQEAKKKYYMQKRKDQQARERDRTIQQAAGPPFVPQRTDGPRFTGGGFNLQQSSKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J504</accession>
    <name>A0A6P8J504_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NEDD4 family-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116308803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575156.1">
        <property type="nucleotide sequence ID" value="XM_031719296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J504"/>
    <dbReference type="FunCoup" id="A0A6P8J504">
        <property type="interactions" value="2137"/>
    </dbReference>
    <dbReference type="GeneID" id="116308803"/>
    <dbReference type="KEGG" id="aten:116308803"/>
    <dbReference type="InParanoid" id="A0A6P8J504"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031575156.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26329" checksum="C2C06680301D7C3D" modified="2020-12-02" version="1">MAGNQRYVPIATSEETAPDSQPAVLSVVATPPQPVHLTPTQDNRTVNQAAYVEIPPDVPPPPYVSYDIDEPNDENNISPPAYEVASKLPTYEEAEGVREINEDLEQRNALLVDGGQEVALGTDWLFVLCFAMAFLFNWLGFFAAYCLTRTVASRYGAIAGFGLSMVKWVWIFKEAAKSREEIIYGQDWIWWIFFALGWLLFIRATLAYLHIKLLVRRGCRRFPHYWGLPVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5I1</accession>
    <name>A0A6P8J5I1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575381.1">
        <property type="nucleotide sequence ID" value="XM_031719521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5I1"/>
    <dbReference type="GeneID" id="116308992"/>
    <dbReference type="KEGG" id="aten:116308992"/>
    <dbReference type="InParanoid" id="A0A6P8J5I1"/>
    <dbReference type="OrthoDB" id="5847109at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_bL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_bL35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575381.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21706" checksum="FC06247D3CC53799" modified="2020-12-02" version="1">MAARVGFFRLSAFSNISCKKIPIDRRIASRNLHSLSKSPGVGISKTTTNSSLVIIGKYSRSTLFSSSYGLLSSKIQTPSFQRSLSMFVGILHHSKIASSTEHIVKPAYGNMENRFTVIARNINIMSKRGKRKTCKAVAKRVHRTGKGKLKRWRAGKNHGMIRKSNKRRKQLKKPTYCNKQQLKLLNKMLNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7E4</accession>
    <name>A0A6P8J7E4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18" type="primary">LOC116307622</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16 17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573752.1">
        <property type="nucleotide sequence ID" value="XM_031717892.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573753.1">
        <property type="nucleotide sequence ID" value="XM_031717893.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573755.1">
        <property type="nucleotide sequence ID" value="XM_031717895.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573756.1">
        <property type="nucleotide sequence ID" value="XM_031717896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J7E4"/>
    <dbReference type="GeneID" id="116307622"/>
    <dbReference type="KEGG" id="aten:116307622"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="42"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031573752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031573753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031573755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031573756.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38602" checksum="6E0F6DC694E12242" modified="2020-12-02" version="1">MLLRQDANFSHPNSTSHSSEDKGFHVQTQLPLLILAVIIVILNGTIVGLFVKKRSLRSFTNYFLVSLAISDLLTAFLAIPFFISCNATEKTEICTASNQFFVFTTLSTICHIAAITADRYIAILKSLRYQELVTKKRVQLVTATIWLYCSFMTVIQLSWTVSSEESLNDIPDEDYQKKDLVYTIMFVILGVIPIPFMVLAYCRIFVQILRQNSLTRQHNRLVERGDKKIWTFELRTVSMFVLMLLAYVFCLLPNAALRLELNINGTLDRIPMYVLHIIVYLYFMTSFLNPCFYGLGKHDLRCALSELFAKTFAQRRQMKQNMNVSYRTGCDSALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9W9</accession>
    <name>A0A6P8J9W9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116308282 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574533.1">
        <property type="nucleotide sequence ID" value="XM_031718673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J9W9"/>
    <dbReference type="GeneID" id="116308282"/>
    <dbReference type="KEGG" id="aten:116308282"/>
    <dbReference type="InParanoid" id="A0A6P8J9W9"/>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000001">
        <property type="entry name" value="neuralized-like protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="270"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031574533.1"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113382" checksum="FDE23BC2468584BD" modified="2020-12-02" version="1">MGAKQSLKKRLRQDLADALFRSAMLEALQEAANESDGSSEMLEHAWDPSDCSPPFVVLPDRLTARRQLSILTSDCIRGKKRYRDGQHVWEINWENEERGTFAIVGVATPKAPLQSLGYEPLIGSNSESWGWDIVSKTLWHCGKRGSYPAVGTGFQVPDTFFVILDMDQRTLSFSTSDLHLGVAFTDLPKQLDRPMCPVVNAIFGNCDIRMRYMGKGESIISNLRRPIAFHRATSETPSEAPKKASEDSRRKSTGTPGKDSDSSVVEASKRYQFARHKHGENVAVMYAGKKAKRVDPFGSCCDGVVITSEPLKDNELFEVRLDSKIDRWVGSLFIGATTNDSNSFSTFPQIMVDYTQGSNFMWAGDQIVFNKKLTTTVKEDTGKLTTGDRIGVMRKSDNSLHFYLNGKDIGNCFKTIPDVLYGVVDIYGQAEQVTITGGTAETQSSNDDEESVEQDHIIVMVQMKKVIELMKLPFNPLLIIKMLYQGVLEPYTDTRDRAVRQRYGDHLSDIGAVPELKKFLERLDRPDLGIESEEGWVGITIVRSILWNYSDASLKIAKEIGKCGLLGRFVNDLKRIGPSGAFGDEKQKRIIDSAVNILHNCAKATENRQVFRDINAVEILAPFLKCEESEVVISALLAMSYITEDNQSHLLDADTKTISQIQGMLVNAANSPGLRGASGSCTWSALEIVSGIANIAVNEKNRANLIDAGVIPPLFDVIKKGDPIDKECSANALWLLANSEPGKKKIRDYPGAMATLNELSKNSNKSIAAAAKRVLLRIKQQPMKQGVSLKGIPRKNCAYKETCRLFIKSLNLNDVLFDHKFDKCYCTECHASRNEKLYYTQGKPAKDYSIPIGWARSALKMERTALVHNCNKDWHVAYHGTSPDSVKSILEDGKLLMPGDETLEGRRLSEVDGHFTDDNKPEGFNTKQIFVSPSIRYSGLEVYAKSKRFEDPQTKKTYKAKVVFQLWIKPDSYKVGQQTVGAENEIDPKFSNQEIEWATARRSAIHLYGVLVHLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JA80</accession>
    <name>A0A6P8JA80_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307602</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573730.1">
        <property type="nucleotide sequence ID" value="XM_031717870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307602"/>
    <dbReference type="KEGG" id="aten:116307602"/>
    <dbReference type="InParanoid" id="A0A6P8JA80"/>
    <dbReference type="OrthoDB" id="10068389at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33776">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33776:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573730.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34437" checksum="789537470FFC9DAA" modified="2020-12-02" version="1">MGILNINSLRKHIDELRIVMSNDILDILAINETKLDSNDCDSQFSIPGYALIRRDRNKXGGGVCFYIRDSISFRRKKNLEDDELEIIIIEIRKPNSSPFLVITWYRPPKLPLDFFDKFVNVLHIIEDKYKEIYILGDLNCDLLSNPPELHTSRLNDIFDEFQLEQIINEPTRVTKKTESLIDHVISNCKNNIIQSGVYALSISDHYLAFAIRKIGIPRGRPKIIETRNFKNFVCEDFENDLKNTVWPLFDQLKNVDEAWASWKKIFLKTIDKHAPTRLIKVRNKPSPWINANVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCX0</accession>
    <name>A0A6P8JCX0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116309047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031575438.1">
        <property type="nucleotide sequence ID" value="XM_031719578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCX0"/>
    <dbReference type="GeneID" id="116309047"/>
    <dbReference type="KEGG" id="aten:116309047"/>
    <dbReference type="InParanoid" id="A0A6P8JCX0"/>
    <dbReference type="OrthoDB" id="5978370at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031575438.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18277" checksum="B1AD60C52B4249D6" modified="2020-12-02" version="1">MASEREKYREILQRNLRAFPNISALKPEQEDCILAVLDKKDVFGILPTGFGKSLIFQLLPRIMKEAWQIERATVIVVTPLVSIMKDQVTELKEHGLNAFPLLNEESDEDILNSLETAELIYGIFETWLSQRWLKELKDGQLGKQIVSIVIDEVHSVTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JFW5</accession>
    <name>A0A6P8JFW5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUMO-conjugating enzyme UBC9-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575195.1">
        <property type="nucleotide sequence ID" value="XM_031719335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JFW5"/>
    <dbReference type="GeneID" id="116308830"/>
    <dbReference type="KEGG" id="aten:116308830"/>
    <dbReference type="InParanoid" id="A0A6P8JFW5"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575195.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20806" checksum="DAA82290D4C49990" modified="2020-12-02" version="1">MKLFKMADAHRVRVDPIERIQEEYQAWKRYHPKDFIANPSKKEDGSTDWLTWKCGIPGPEKSPWEGGLYPMQMEFPTDYPYSPPKCIFTPALLHPNVFPSGTVSLSLIDKNKGWKPQVTMKQVLLGIQLLLKDPNFHEPAQAEAFVIHSQSSLDYENKVKELAKQMDPARSNILQNLIPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GX38</accession>
    <name>A0A6P8GX38_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116286454 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548829.1">
        <property type="nucleotide sequence ID" value="XM_031692969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286454"/>
    <dbReference type="KEGG" id="aten:116286454"/>
    <dbReference type="InParanoid" id="A0A6P8GX38"/>
    <dbReference type="OrthoDB" id="152385at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028220723" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="182"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="336"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="489"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="642"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="739"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="833"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="930"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031548829.1"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117742" checksum="1FD45B17917090DC" modified="2020-12-02" version="1">MEVGSDGRYVYFRVIFAIFLLHRTQGCQDSPVGIADSSIIPDDSFTASSSYDNRHVAKNARLNEVIGRGWGPNTNIDPNDYLQIDLGEVFAICALATQGSSGYTEWTTQYKISTSVNESTWTNYTIDGKVKLFPGNTDSNTVVKNVLDYPVLLRYIKFIPTAYNTHKVLRVEAYGLGRGLLCSSLPVGIGSGKIPDRNMTSSSAYNSTTSPSKGRLNYTAGSSWCAATIDSSPYLQINLGSPYIICGIATQGDHMTDQWVQSYNMLTSNNGSTFTKYVENSQVKSFAGNFDSNTAVKNLLYDGTVSQYIRVAPTSHFGSTNCMRTELYGIKHDGGCTFMFVGLSYPSIIPDHRFTASSYYDDRYKPSFARLMTFSKAAWGPLTNSGGDWLQIDLGPVVYVCAVATQGAGALNDEYVTRYKIKVSLDNVNWNYYQENKDDKEFPGNTDRAAIVTNKLRNPVRAKFIRFYPTDYSTYPTMRAEVYGIPSACNSPVGLETSGVIQNSQMTSSSHLYNTHTASHGRLYGSNSWCSSTSSNTQYIQINLGRLMTVTGIATQGDQTMDKWVTNYTISYSMDGNLWNTYKAGSNRNEIFQGNSDKENVRVQWLSNPMTARHVRVTPQTWNTAICMRIELYGCDYDYPLTLAAPTVHDINSTSVTVRWIQPALNASQASVTTYVLQYQNITHTQTISVSAPATSHVITGLAIYTNYNVKIIAISRIGSGQWSATTDFRTNSALPVGFPYSVAAVSKTSQSIHVTWQAPTXGINGPFLGYRVLCRSGNERHENTSQQTSHTFRGLRQGTVYNVTVVIRNDKGDGPINGYVRIQTLQDDYPMTLAAPTVHDINSTSVTVRWIQPALNASQATVTSYVLQYQNITHTQTISVSAPATSHVITGLAIYTNYSVKIIAISRIGSGQWSATTDFRTDSALPVGFPYSIVAVSKTSQSIHVTWLAPTSGINGPFLGYRVFCTSGNERHENTSQQTSHTFRGLRQGTVYNVTVVIRNDSGDGPINGYVRIQTLQDGELLEIRLHMNLHCILSTLLCKCLYAPSLTISQMITQTLLVGLPLVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6G4</accession>
    <name>A0A6P8H6G4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide FF receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551989.1">
        <property type="nucleotide sequence ID" value="XM_031696129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6G4"/>
    <dbReference type="FunCoup" id="A0A6P8H6G4">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="GeneID" id="116289240"/>
    <dbReference type="KEGG" id="aten:116289240"/>
    <dbReference type="InParanoid" id="A0A6P8H6G4"/>
    <dbReference type="OrthoDB" id="5951670at2759"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551989.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43047" checksum="D9764D23B6D30795" modified="2020-12-02" version="1">MGRRVSNSNQSYSNSNDLEWRDVEWRLGIDITIFVVAVIGNLAVLVVIYATRERRKTPFEILIANLSVADILSVLLLFVYHFNIPRSKWFCKLQGLFFSSTQMVSLLTMTTIAIFRCRSIVYPFKTKPSSKFTYCTVAGLWVVANICLMPVSLVMENVNGGLSCEEIWSSELLNKVYTVSLFVVQYMIPLTIMAISYTKIILYLKRNKVQCGLNSDRINQHKMTRKRDMEVIKISLIIVLLYAISTLPNQIAWIDMIVFESYDMSSLIFEFSLQLLLLHSCCNPFVYGTISREYRSRFVQVFWSISCCFCKIRRTQTGVLQTEQGQRNNDCDLEMIEIKGYVKRDGTAIVPTTPTDRPTDRPNSEPTKQPSNQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6R2</accession>
    <name>A0A6P8H6R2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPI-anchor transamidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116289334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552084.1">
        <property type="nucleotide sequence ID" value="XM_031696224.1"/>
    </dbReference>
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        <property type="interactions" value="1192"/>
    </dbReference>
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    <dbReference type="KEGG" id="aten:116289334"/>
    <dbReference type="InParanoid" id="A0A6P8H6R2"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028430071" evidence="6">
        <location>
            <begin position="24"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552084.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43373" checksum="1C6F5F8D82E73016" modified="2020-12-02" version="1">MAAFRLLFLCLAISLSGFSNVLGEERVPLDNVFKRGHTNNWAVLVCTSRFWFNYRHVANVLSVYRSVKRLGIPDSHIILMTADDMACNARNPRPGTVFNNVNQHINLYGDDVEVDYRGYDVTAENFIRILTGRLPESVPRSKRLLSDERSNILIYMTGHGGDGFIKFQDAEEITSVELADAFEQMWQKRRYHELFLIVDSCQAHSMTLKIYSPNVVGVGSSLVGQDSLSHHDDPAIGVHVIDRYTYFLLQFLERIGPASKATVGELFEYTSPDRVMSTPGVRTDLFERDVDKTLLTDFFGSIHEVEISNVSSVDLKHEVICSSGDCVSNENLPKEHTDTRQFCNQFPIQEILKEETATSWPIRREFLFGAVVFSLASVISLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H857</accession>
    <name>A0A6P8H857_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116288962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551686.1">
        <property type="nucleotide sequence ID" value="XM_031695826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H857"/>
    <dbReference type="GeneID" id="116288962"/>
    <dbReference type="KEGG" id="aten:116288962"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551686.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21223" checksum="2F87D6E9808998BC" modified="2020-12-02" version="1">MPDRCVVGGCSNESSLQLGISLHRIPFFADERPEAKKRRKKWTDFVLKTRKHWKATKLSAVCSDHFLFNDFERYALEIPNTKFYSPRLKKDGVGIVVFPTITKVREEKPPSARSLRQEKKEREETIRTLVEEQDDGHIAEDEDEDPRTSQVAKCKILVRSIHSGQKHQNWYKCRLEYGNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAC1</accession>
    <name>A0A6P8HAC1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein C14orf28 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552098.1">
        <property type="nucleotide sequence ID" value="XM_031696238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAC1"/>
    <dbReference type="GeneID" id="116289346"/>
    <dbReference type="KEGG" id="aten:116289346"/>
    <dbReference type="InParanoid" id="A0A6P8HAC1"/>
    <dbReference type="OrthoDB" id="6156483at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552098.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17268" checksum="DF387A33CBC85595" modified="2020-12-02" version="1">MSYFVLLVKDTKKFNGSPPTGAPVYRMEDVSTEDSTTSSNVYCDGARTTYPRVFPDGMPLIIPVDVELLAAQGVRLRMKNIPADMTILDHKYELQAVTLRSGKYEHYTCIFKYNSNWLYYDGLCNEGKPSLFTNFPHTYRPNTLLYVKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB35</accession>
    <name>A0A6P8HB35_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ZP domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116289523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552328.1">
        <property type="nucleotide sequence ID" value="XM_031696468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HB35"/>
    <dbReference type="GeneID" id="116289523"/>
    <dbReference type="KEGG" id="aten:116289523"/>
    <dbReference type="InParanoid" id="A0A6P8HB35"/>
    <dbReference type="OrthoDB" id="2015116at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552328.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20515" checksum="3E12611F0D7AC675" modified="2020-12-02" version="1">MVYNNQNFIITTKYSSFLSSNNYYCNCYHGFTGRQCETRFYGNITFIMDLYQTSNYSTPYSPSAYPVVVYPNQSLWVQYEVKSTTFDLVVFAENCCANNSTNPDSFPQHVFLERGCIVDSTMVYFHNPYSKVQRFSIRSFRFAYSNSHLVCLHCELLVCHQNSTNSRWCCWLCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBF7</accession>
    <name>A0A6P8HBF7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116287480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550017.1">
        <property type="nucleotide sequence ID" value="XM_031694157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBF7"/>
    <dbReference type="GeneID" id="116287480"/>
    <dbReference type="KEGG" id="aten:116287480"/>
    <dbReference type="InParanoid" id="A0A6P8HBF7"/>
    <dbReference type="OrthoDB" id="6362917at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026182">
        <property type="entry name" value="ANAPC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22526">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22526:SF2">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15243">
        <property type="entry name" value="ANAPC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550017.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12721" checksum="5120DA2743D03B49" modified="2020-12-02" version="1">MAVFPSLLPRLTDDLWFSVDKRLDDDAILAKEEEEYISHLHSIVEKGNDIVPLGKSKESNEGQEDEEEEEEEMEDEDSAEELEDTDDYDDSPSPDAESVEEEVEMMDSSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBM2</accession>
    <name>A0A6P8HBM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553026.1">
        <property type="nucleotide sequence ID" value="XM_031697166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290173"/>
    <dbReference type="KEGG" id="aten:116290173"/>
    <dbReference type="InParanoid" id="A0A6P8HBM2"/>
    <dbReference type="OrthoDB" id="6378758at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553026.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19873" checksum="A66364774D09F1EA" modified="2020-12-02" version="1">MTGYKIQRAECWPHCKLNSTEKHNMENLAIDPEVTDLISQWIEEATASKKVDEMKCFACGKXFTHRXSLLRHHRERHNDTTEKFPCPNCEKKFSRAYDLRRHEKNCNGGSSKRKLKDKENSLPLKKQKMSDQEIIEYELLNTPPQMLEEYDGEILGDEKEVIFFFLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBN1</accession>
    <name>A0A6P8HBN1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Octopamine receptor beta-2R-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553834.1">
        <property type="nucleotide sequence ID" value="XM_031697974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBN1"/>
    <dbReference type="GeneID" id="116290860"/>
    <dbReference type="KEGG" id="aten:116290860"/>
    <dbReference type="InParanoid" id="A0A6P8HBN1"/>
    <dbReference type="OrthoDB" id="5978338at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="34"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553834.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32460" checksum="C2CCB8229D5FC430" modified="2020-12-02" version="1">MCVNDSCVGVSAPRYLSILTTTVSLSLTLVTVPGNSLICYAILKDPFHELRTPFTFLILSLAITDLLVGILMDPISTVFHLSEALKIDLVDIWILHISYFILSTASILSLGALTIDRYVAVIYPLKYKSYLSTKKCIYLSLVIWLVSIGLSMVYFKFGYISYSLIFASTAVSLTFLVLLFVYVSIFNRLRTQVRSLSRQRASSTQANRMNKKKISSLKWEAKVTKALVLVLLAYILCFAPACIIIYILNFCTKCNCEFIHWLRDLQFVIVLLNSAINPYLYAWHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC02</accession>
    <name>A0A6P8HC02_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553954.1">
        <property type="nucleotide sequence ID" value="XM_031698094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC02"/>
    <dbReference type="GeneID" id="116290971"/>
    <dbReference type="KEGG" id="aten:116290971"/>
    <dbReference type="InParanoid" id="A0A6P8HC02"/>
    <dbReference type="OrthoDB" id="20550at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553954.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51584" checksum="31FE666259078E75" modified="2020-12-02" version="1">MTTRFKSDSIILLCDLLSAQKGEDSSSSEDEDGPTTPYIKIKSAHGKGPEEFEKLKLLQDLSGEHVGAIWTVKFSVCGRLMATAGQDHMVRVWVLKENIEYFEEMREKYSNSGGHKAKPDPEVDQILENDEEEGQGSDSGSEKENVEEGNEEDNKKKEPPEDDNGPFMKKPFCTYCGHTGDILDLSWSKNYFLLSSSMDKTVRLWHISRTECLCCFQHIDFVTAIVFHPRDDRYFLSGSLDGKIRLWNIPDKKVALWNEVEGTGSNLITAANFCLQGRFAVVGTYDGRCIFYETERLKYHTQWQVRSSSRNKRSRGRKISGIEPMPGEEKVLITSNDSRIRLYDLKDNSLSCKYKGCTNASSQIKASFSHDGQYLICGSEDHFAYIWRTQHGIPSARRDKNEFYESFSAHDAVVTVATFTPVPWLIIPPDTSGIPVTSEVLVTADWSGAIKLFVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HD36</accession>
    <name>A0A6P8HD36_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552978.1">
        <property type="nucleotide sequence ID" value="XM_031697118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HD36"/>
    <dbReference type="FunCoup" id="A0A6P8HD36">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="GeneID" id="116290125"/>
    <dbReference type="KEGG" id="aten:116290125"/>
    <dbReference type="InParanoid" id="A0A6P8HD36"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13113">
        <property type="entry name" value="Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF81">
        <property type="entry name" value="WNT INHIBITOR OF DORSAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027784672" description="Protein Wnt" evidence="9">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031552978.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37803" checksum="74A25CD121F40F5A" modified="2020-12-02" version="1">MTRVVFFVTIFLLFSFATSLSGAKWSALKILQTGREAYEKLTESVREGAKLGLTECKKQFSYEKWNCSITFRNKRLADMPIFIQSSLPLANKETAFVHSISAAGVTYRLTQDCRRGKFENCDCVQSKKKSAKEWGGCHDNFKFGDTLAKHFLDVLEKNNKARSAMNIHNNEVGRKAVRATLMKECKCHGVCGSCSTKTCWKQLAPFEKVGNYLKEKYLKAKEVRVKKDKLVQKIKPKTFQPIAKKDRSLVFIESSPDYCRYNATAGSLGVLGRVCYSDSPNYAKCNNLCTACGYNIQKKLLVRSVKCECKFEWCCRVKCKTCMQLAAMTTCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDD3</accession>
    <name>A0A6P8HDD3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein arginine N-methyltransferase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histone-arginine N-methyltransferase PRMT2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116287996</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550570.1">
        <property type="nucleotide sequence ID" value="XM_031694710.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HDD3">
        <property type="interactions" value="1504"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116287996"/>
    <dbReference type="InParanoid" id="A0A6P8HDD3"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000007">
        <property type="entry name" value="Protein arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000016">
        <property type="entry name" value="Protein arginine N-methyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF92">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="15">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550570.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52989" checksum="4E50B91025ECC070" modified="2020-12-02" version="1">MNDMVNESNTKTTTASVLNANKAGQDSDEGSLSXDNQDDKEWYEIARRLEIVVAIADYSPNDDSQLSFRKGDXLTVLSKETNDWWWTELDGSCGYSPVNYLVRQEDYETENKWQDEEYFNSYGXLGLHLEMLNDRPRTCAYKRAIQQHAGYLKDKVILDVGCGTGILSLFCAREGECKKVYAVEASNIADLTTEIVKQNNFQDKIIVKKGRIEEVELPEKVDVIISEWMGTFLVFEFMIESVLAARDAWLKPEGIIWPSHAKLFLVPCSTKDPYDKKVEVWRDQYGFDFSPALEVSKREFLSRPIYDHIFNMDDCLSEPKLLTQFEMMEIRKEEIEVCAPSFEFEVNEDSLLYGFCSWFEVVFGGVPLSNGTRYVTLPTSPDSELTHWKQDLFLLDEPITVQKGNYLKGTIYIKRNPEYRRHLTVTYDFIVSYGHSVDNGDISREIINDVKKTFYIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDH5</accession>
    <name>A0A6P8HDH5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase MIB2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116290770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553731.1">
        <property type="nucleotide sequence ID" value="XM_031697871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDH5"/>
    <dbReference type="GeneID" id="116290770"/>
    <dbReference type="KEGG" id="aten:116290770"/>
    <dbReference type="InParanoid" id="A0A6P8HDH5"/>
    <dbReference type="OrthoDB" id="5977506at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000044">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000004">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031553731.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16906" checksum="FBB6F61D39A77FB7" modified="2020-12-02" version="1">MYLLGCRVVRGPDWTWGDQDGGEGGVGTIFSTDTFSDGSPLKNQTVVVCWDTGQEAYYRLGLDEKYDLRILDSAPSGVCFEKVICDGCRQNPLLGTRWKCTDCDDYDLCTQCYNNEVHDLDHSFERHDHCKLQRYLKNIPYAYPLCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDI4</accession>
    <name>A0A6P8HDI4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone acetyltransferase KAT2B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116291445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554474.1">
        <property type="nucleotide sequence ID" value="XM_031698614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDI4"/>
    <dbReference type="GeneID" id="116291445"/>
    <dbReference type="KEGG" id="aten:116291445"/>
    <dbReference type="InParanoid" id="A0A6P8HDI4"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554474.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37287" checksum="7AEE7AD50D3274E8" modified="2020-12-02" version="1">LELSGIKRPHEDDDDAETSAKKPKLAGEVSLDVLKKFVEVIDDPSSMLGPEGGLYPGAQSARDEHARCEERRGVIEFHVVGNSLRRTPSNQTLLWLIGLQNVFSYQLPRMPKEYISRLVFDPKHKTLALVKDNRPIGGICFRMFPSQNFTEIVFCAITSNEQVKIVKKLTARKQEQIRKIYPGLTCFKEGVRQIPIESVPGISETGWKNCLKKSTTKDIDPAILQTQLKNILTQVKNHASSWPFQKPVERSEAPDYYDHIKYPMDFKTMTERLKSGYYSSKKLFIADIRRIFENCRTYNSPDTEYYKCANIVERFFLSKIKDPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE34</accession>
    <name>A0A6P8HE34_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoplasmic polyadenylation element-binding protein 1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPEB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553961.1">
        <property type="nucleotide sequence ID" value="XM_031698101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HE34"/>
    <dbReference type="FunCoup" id="A0A6P8HE34">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="GeneID" id="116290981"/>
    <dbReference type="KEGG" id="aten:116290981"/>
    <dbReference type="InParanoid" id="A0A6P8HE34"/>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12723">
        <property type="entry name" value="RRM1_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12725">
        <property type="entry name" value="RRM2_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000054">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000086">
        <property type="entry name" value="Putative Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034977">
        <property type="entry name" value="CPEB1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF9">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="229"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553961.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53648" checksum="9B46560DA1D21DDF" modified="2020-12-02" version="1">MTQENREGKCSILNHLNALLDSALDPNLAGRGLFCPPQSSQPPPTTYYNNPYFSSYYQVTPPDSRSASPMNYEDKLSEHLLHNLATSSVMGTPSPPGSMPSSPMGFKSSQSPCAAFPFSPLTPDSDISPIRPSYSGVLMSGDSTARQQLFRASASQVEQDLMAVTGRSLLTDPRWGSSKMSGFLGDLTGQDWLQRQSLLQQAPDFMRLNMKKWSGQLPRRNYKNTSYSSKVFLGGVPWDITEASLLLSFKPFGNVKIEWPGKADGRHLHHPPKGYVYLIFDSEKSVKALLTSCTHDFTNGGDWYFKISSRRMRCKEVQVIPWVLSDTNYVRGPHQRLDTSWTVFVGGLHGMLNAEGLAYIMNELFGGVVYAGIDTDKHRYPIGSGRVTFDNHKSFMQAVRAGFIEIETPKFTKKVQVDPYLEDSLCETCHATQGPFFCREESCFKYYCHSCWMWHHSIEGYRDHRPLTRTSKSAGSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEZ4</accession>
    <name>A0A6P8HEZ4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553578.1">
        <property type="nucleotide sequence ID" value="XM_031697718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEZ4"/>
    <dbReference type="FunCoup" id="A0A6P8HEZ4">
        <property type="interactions" value="1081"/>
    </dbReference>
    <dbReference type="GeneID" id="116290636"/>
    <dbReference type="KEGG" id="aten:116290636"/>
    <dbReference type="InParanoid" id="A0A6P8HEZ4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002048">
        <property type="entry name" value="Septin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="41"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="323"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553578.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="49201" checksum="B0A83CF5FC2D5B9F" modified="2020-12-02" version="1">MTSAVTDYCRSLGANGRQLRLAGHVGFDSLPDQLVNKSVNSGFAFNILCIGETGIGKSTLMDCLFKTTFEGEPHSHHLPGVQIEHHSYDLKESNVRLKLTVVDTVGYGDQINKEDSHTPIIDYIDKQFEAYLHQEMKIKRALNTFSDTRVHACLYFVSPTGHSLKSLDLVCMKKLDKKVNIIPIIAKADTIAKSELQAFKEKITEELESNGVEIYKFPTDDETVAEMNNSMNGEIPFAVVGSRDEVAVNKKNVRARVYPWGTVEVENENHCDFVKLREMLIRTNMQALIDKTHAFHFELYRRSKLEDMGFSDGDANHEPHSLQETYEQRRKEYMQEFQEREEKMRQRFVQKVKDKESELKMAEQELHAKFDHLKKVQADEKRKIEEKRHMLEEEISLFTKKKAAVTAAQASAQQATAQVAKEQLKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFM0</accession>
    <name>A0A6P8HFM0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin-alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554586.1">
        <property type="nucleotide sequence ID" value="XM_031698726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFM0"/>
    <dbReference type="GeneID" id="116291550"/>
    <dbReference type="KEGG" id="aten:116291550"/>
    <dbReference type="InParanoid" id="A0A6P8HFM0"/>
    <dbReference type="OrthoDB" id="5975176at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554586.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20719" checksum="3538250614346BA5" modified="2020-12-02" version="1">MHNQQVCSSPEHISKELEVMEYLSEEQIQEYKVVFEAIQKDDKRPKSHIKRRELGIAMRMIGLNPREDDLQEFINTIEFEDNGRVDFAQFVEMMEEQRSHSQEEEDEVRMAFNVFDSDCRGYIEANELRYVMETVQIAPEEKLNEMLQDLGIDKERKISFEEFKTFVSPKTNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGD5</accession>
    <name>A0A6P8HGD5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116292323 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555469.1">
        <property type="nucleotide sequence ID" value="XM_031699609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGD5"/>
    <dbReference type="GeneID" id="116292323"/>
    <dbReference type="KEGG" id="aten:116292323"/>
    <dbReference type="InParanoid" id="A0A6P8HGD5"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="5">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Impact N-terminal" evidence="4">
        <location>
            <begin position="406"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Impact N-terminal" evidence="4">
        <location>
            <begin position="557"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="665"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="344"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555469.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="80059" checksum="9CC33A7792C2FCA6" modified="2020-12-02" version="1">MASAPADPSEILRSSTEKNNYTRLTRLLIEGGTFILRELLDKIIPPHQFKHVLMLPKVHSKLKLLKKKKVITPLQWKSLFPTVTSWGKSTDFDITLIFKLLRNFCSLTPPPKGWDELPDDKDLTLPADLARIKYYRNDVYAHNDKMELDDSEFQNLWKRIKDALMRIVQHYNRPNPSAVLKWETAIEKLLTDPLDIKKSHEDNDKLKIWCIDDPQTLSDLKDENARLKDQVTRLESSLVNVHCNWRSRMQWMIAGSVSTLLILNYKDDPESLINMISDALPVGLVVKSIVAGSIVLQLTSTSDEALNDLLTRYQSGQLREDLAKIFMTEEIKALFDGQDVEFSVEICEEEIENARRVLISAAEAEKKREELTKKEGLAQALKKTKLTTDLNIFDGEIVEDGENRVQAHLAVITSKDQVEEVFAELKKKDPGVDEATHNIWAYRIFDAERNVYHEHCDDDGDDTSGARVLRFLRRTNAMNVIVVVSCWYETTADELGEVRFKYIQKSVLDLLLTSGIEIRTSKIKKYFEEIKYTPFEKMKEQEIPKFEILHGETIEDRKSTFQAHLADITSREQVDQVLDELKKDRKIAKATYNMWACRIYDEKKKSYIEEGYDDGENLGGERLLHLLQRSDAKNVVIIVTRWHGGIHLGNDRFKHINKCASDLLQRRKTAESRTSTASTDPKSTATKKKKSKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHF6</accession>
    <name>A0A6P8HHF6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555834.1">
        <property type="nucleotide sequence ID" value="XM_031699974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHF6"/>
    <dbReference type="GeneID" id="116292628"/>
    <dbReference type="KEGG" id="aten:116292628"/>
    <dbReference type="InParanoid" id="A0A6P8HHF6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555834.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58130" checksum="37288611149F955F" modified="2020-12-02" version="1">MFASSFTETEKSEIVLREVEPAGVKAILNYFYTATIELDSSNFEAIFATANLWQVEFVLQACEHFLEQELSTSNCLGIQILVNANLTFTERLRKLVDGYVNAHFMEICEEEEILTIPKEHFKFLLVKDELCVSFEEFLFESVLRWLKHDVNIRGCYATELMSAVRLGLLRKDFIQEILLREKTILENSSLNQLLNSVVKFLHGDQSVKISEYLTRKRKCEVLYVFGGFSSNSHRLRPAKAIDSVEFLNVLQEKWENFPEAKLPDAKETQFKLVAGDGYLYAVGHKIFSFCLKRLVWEKLYPKSMGFRPLDIKNAGVCFSNGCIYVIGGVKGAQKFNPSDCTWYKISSSSNGLVEEHYRPGVCAHDDVIYVIGGCDSSYNDGKDSVESFVVESGVWLRKACMCTARWGLEAIPLKDRIFAVGGYNTEERCALNTVEVFTPSTDTWQNTSPLTAPRRRFGSAVVNGMIYVVGGYEVESVEYYDEVKERWVVVNGLTINRFDCSCWSMQPPNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHL6</accession>
    <name>A0A6P8HHL6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554433.1">
        <property type="nucleotide sequence ID" value="XM_031698573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHL6"/>
    <dbReference type="FunCoup" id="A0A6P8HHL6">
        <property type="interactions" value="2557"/>
    </dbReference>
    <dbReference type="GeneID" id="116291404"/>
    <dbReference type="KEGG" id="aten:116291404"/>
    <dbReference type="InParanoid" id="A0A6P8HHL6"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="10">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031554433.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16952" checksum="D10B40EECAB47050" modified="2020-12-02" version="1">MSEDFGGGASGASKHYPSQASALRKGGHVLIKDRPCKIVEMSTSKTGKHGHAKVHLVAIDIFTNKKFEDICPSTHNMNVPHVKREDFQFMGIDEDGFLSLLGQDGSQKDDVQVKEQDLINEIKDKEAKGEEFMVTVLQAMDEEKACGTKNMASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIS8</accession>
    <name>A0A6P8HIS8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC116291707</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell projection</location>
            <location evidence="17">Growth cone membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554778.1">
        <property type="nucleotide sequence ID" value="XM_031698918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIS8"/>
    <dbReference type="FunCoup" id="A0A6P8HIS8">
        <property type="interactions" value="1451"/>
    </dbReference>
    <dbReference type="GeneID" id="116291707"/>
    <dbReference type="KEGG" id="aten:116291707"/>
    <dbReference type="InParanoid" id="A0A6P8HIS8"/>
    <dbReference type="OrthoDB" id="10037042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028386446" description="Lysosome-associated membrane glycoprotein 5" evidence="23">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="24">
        <location>
            <begin position="99"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="25">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_031554778.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="36862" checksum="2105EDCB1AB7D44B" modified="2020-12-02" version="1">MYQVLIFVACLAVGFGANNTNMSITINKPSPSPTATVSMMGQSSMTVAINTTLSTVFSMTSALSMSSSITSLAPYSTTAPRPSVTPTSKPPVPKPTPKPTYGDYSVKKNDKYCLLAKLAVSFNVTYYRNETEKEGNKTIQKNVKDFAIVGMPFKDVLTNESKCGDDDSTLVVSWTFYVFTMSFRKIKDENKASPGWEVTEVSLDISTQNNSHFPNAKDKLLTFKANGDNKTRVHQLSGNLNGSYLCDIEKDYPFNENGTMIVKHAQLQPFDVQNDKKREEMFGEANKCEAKDSKSSNGPSNIVPIAVGCALAGLVLIVLIAYIIGRRKSQRGYEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJV0</accession>
    <name>A0A6P8HJV0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556659.1">
        <property type="nucleotide sequence ID" value="XM_031700799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJV0"/>
    <dbReference type="GeneID" id="116293377"/>
    <dbReference type="KEGG" id="aten:116293377"/>
    <dbReference type="InParanoid" id="A0A6P8HJV0"/>
    <dbReference type="OrthoDB" id="5957108at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009704">
        <property type="entry name" value="EURL_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15961">
        <property type="entry name" value="PROTEIN EURL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15961:SF3">
        <property type="entry name" value="PROTEIN EURL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031556659.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32141" checksum="36E8D64AC7F33C0F" modified="2020-12-02" version="1">MDGFDTISLESNTCDICNQDTGEELIDCILNDRCLQVRENSVDGKEPYKRAHKDCLHKWKTVIQATLTARCPSPKRTWKDRIKDLLIRHEESNANDTWLRVDCAPKNHDSIQVENSKTLNLNSNQNNNKTSSRRHCFLTNEEYRIERTEDEVGSCEERARKLRVRSVDKEDEDFDVSKDLQLNDKYEDAEIFQTSWTVAQLDKMHKNEIEDIIAQIKQRIEEVSTLLISELQEKDSLRQQADILHTTAAQLVKLKQKQNIKTHSLDFEHQHHLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK07</accession>
    <name>A0A6P8HK07_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555223.1">
        <property type="nucleotide sequence ID" value="XM_031699363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK07"/>
    <dbReference type="GeneID" id="116292113"/>
    <dbReference type="KEGG" id="aten:116292113"/>
    <dbReference type="InParanoid" id="A0A6P8HK07"/>
    <dbReference type="OrthoDB" id="5989182at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF42">
        <property type="entry name" value="PROTEIN CBG10204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555223.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19205" checksum="EC3624C731A1867D" modified="2020-12-02" version="1">MEEEPDFSSDANYNTEMESETDPETENEDAQEEESRVFSDDENLRTQPKFIVFWSQLLLLFRFCHTCKADGPLIEAKQVGTMVVVTSTCGNKNCHSRVVVWKSQPNMTGTKIPAGNFLLSFAILLSGASASKTIQMFKHMGLCCFSLATFFKHQNLSTSMIFNVIPVLLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLF1</accession>
    <name>A0A6P8HLF1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase DZIP3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553440.1">
        <property type="nucleotide sequence ID" value="XM_031697580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLF1"/>
    <dbReference type="GeneID" id="116290530"/>
    <dbReference type="KEGG" id="aten:116290530"/>
    <dbReference type="InParanoid" id="A0A6P8HLF1"/>
    <dbReference type="OrthoDB" id="5979063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="2">
        <location>
            <begin position="70"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553440.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25142" checksum="CD48E755435C531E" modified="2020-12-02" version="1">MSEKDIAGMASAPADPSEILRSSTEKNNYTRLTRLLIEGGTVILRELLDIIIPPHHFAHVLMFPIVLGRLELLRDRHIITSEQWKSLFPTDTSCGKSTDFDITLLFKLLREFCSLTSPPNGWDKLPDDTDLALPADLARIKYYRNVVYAHRAKIELDDNWETAIKKLLKDPLDIQKSHEENEKLKIWCIDDPGVPQTLPDLRDENAKLKNQETRLESSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLH5</accession>
    <name>A0A6P8HLH5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="5">PME-1</shortName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031555798.1">
        <property type="nucleotide sequence ID" value="XM_031699938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLH5"/>
    <dbReference type="FunCoup" id="A0A6P8HLH5">
        <property type="interactions" value="2376"/>
    </dbReference>
    <dbReference type="GeneID" id="116292593"/>
    <dbReference type="KEGG" id="aten:116292593"/>
    <dbReference type="InParanoid" id="A0A6P8HLH5"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="72"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031555798.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43431" checksum="AA822E0166BE41E8" modified="2020-12-02" version="1">MSDIHCEALKKRIGIPPLPSRAGQPGGVGGGKRKRDYSPLSWDHFFDRKDDVKVNDKDTFRVYKSGDQGPLLLVLHGGGHSALSWALFTESVTSLCICQVLAVDMRGHGDTHTEDNVDLSADVLAKDIGDLIQSMYGDRPPPILLIGHSMGGAIAVHVGVQNFLPSVVGLAVIDVVEGTALDALSSMQNFLKGRPQSFKSIEQGIEWSIRSGQVHNVKSARISMVGQLIRCDGNSNKPDLVQPAIHIAHTTDTIKEEDEENADEPGQPQAKNQKQSTSNNSGSFVPEKSEECWKWRIDLSKTEQFWEGWFVDMSKLFLSCTVPKLLLLAGIDRLDRELTIGQMQGKFEMQVLPHCGHCVHEDAPDKVAEVIASFLLRYKLTEAKGNFERHFPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLS8</accession>
    <name>A0A6P8HLS8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="16">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116293415</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="16"/>
    <dbReference type="RefSeq" id="XP_031556701.1">
        <property type="nucleotide sequence ID" value="XM_031700841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLS8"/>
    <dbReference type="FunCoup" id="A0A6P8HLS8">
        <property type="interactions" value="1924"/>
    </dbReference>
    <dbReference type="GeneID" id="116293415"/>
    <dbReference type="KEGG" id="aten:116293415"/>
    <dbReference type="InParanoid" id="A0A6P8HLS8"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="38"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="189"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="459"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="22">
        <location>
            <begin position="567"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="674"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1037"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031556701.1"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128405" checksum="9C8B26CF15440996" modified="2020-12-02" version="1">MAAEEKEETAKPLPSLKKLSSKNYGRLSAEQEKSMQDLVRPHIESFNFMLEEGLSLAVQGIPPSELMTAGGQRVSVYFTDASIGVPTISDTNVYSSQMKIFPTECRESGSSYKSKIQVTVQWKVDNEPQGSVTKVIAYVPMMVKSDNCSLARLSPEELVRHHEEAEEAGGYFIINGIEKIIRMLILPRRNYPLALVRSTWKNRGPLYTEYGIQMRSVRKDETAVNMVLHYLSDGSVTMAFGFQKELFYVPVVFILKALVNTTDQHIYKELIRGEEDNTFLKDCVATMLRTAQEEGATNQRKVLEYIGEKFRVKMRLPEWYSDEAVAQFLIQQCVCVHLEANLDKFNMLTFMTRKLYSLALGKCAPESADSPMMQEVLLGGHLYLMVLKEKLEQWLQIVASNLTKASKVKPRQFVVNSASVLAAIAHSSNITHQMEYLMATGNLISRSGLALLQVSGFTVVADRLNVFRFISHFRCVHRGAFFSQMRTTSVRKLLPEAWGFLCPVHTPDGAPCGLLNHLAAACEIVNVLAPVAHLHRLLCTLGMIPHDAPLPGDPKDYYPVVMDGRVLGNVDRDLAPSLENKLRVMKVLGQERVPPLIEVCLVPKTNVASQYPALFIFTKPARMMRPVIHLATGKVEMIGTFEQVYMDIAIIKDEIHQGITTHLEIKQTAMLSAVASMTPFSDFNQSPRNMYQCQMGKQTMGTPVQAFKHRTDNKLYRIQTPQSPLVRPTTHDEYCMDNYPLGTNAIVAVISYTGYDMEDAMILNKSSYERGFAHGSIYKAQFVDLKPKNEKQTSNLQFGCLPNDARTEGRLDSDGLPPIGSKLENGDPFYSYIDNTTGEATIKKYTNLEPCIIDDVKILGNEMGDKPLTKVCIKLRIQRNPIIGDKFSSRHGQKGICSQKWPAENMPFSESGMTPDIIFNPHGFPSRMTIGMMIESMAGKSASLNGHVYDATPFQFSEDDSAIDYFGKLLVKSGYDYFGTERLYSGIDGREFEADIFMGVVYYQRLRHMVADKFQVRTTGPIDILTHQPVQGRKKQGGIRFGEMERDALLAHGTSFLLQDRLMNCSDRTVGHVCSKCGSLLSSVLEKPTHTAGAAQGDRKWYCKSCNSSDNIQILAFPYVFRYLVAELAAMNIKTCLDVNSVGSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLZ5</accession>
    <name>A0A6P8HLZ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-rhamnose-binding lectin ELEL-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555998.1">
        <property type="nucleotide sequence ID" value="XM_031700138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLZ5"/>
    <dbReference type="GeneID" id="116292782"/>
    <dbReference type="KEGG" id="aten:116292782"/>
    <dbReference type="InParanoid" id="A0A6P8HLZ5"/>
    <dbReference type="OrthoDB" id="5988655at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22827">
        <property type="entry name" value="Gal_Rha_Lectin_SUL-I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027908647" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="2">
        <location>
            <begin position="54"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555998.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15849" checksum="AAA02B6FB865D255" modified="2020-12-02" version="1">MKSFTIALLFLLGLLGLTCAAPSKDKAQDAGEVVASDQNGFAIQRRQSTHTYILCEGQNGVLGCPGNKRLRILYANYGRTSRNVCWHLLFMSNTNCHSSYAKRKIRGACNGHNSCRLYATNNSFGDPCPWTHKYIEVHYKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPC4</accession>
    <name>A0A6P8HPC4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554482.1">
        <property type="nucleotide sequence ID" value="XM_031698622.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HPC4">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="GeneID" id="116291454"/>
    <dbReference type="KEGG" id="aten:116291454"/>
    <dbReference type="InParanoid" id="A0A6P8HPC4"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554482.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25250" checksum="9CF853A956326D6B" modified="2020-12-02" version="1">MNARSQVFELSLEGRQVEEAVLSLFHTILFHRTTGKFNYKHGGSYTIGTVGFEDVDCDFVDFTYVRCDSNELDLYIRKQVREFKDALREESGSKSGQISLEFYQKKKGKWLFGAESVPWEIWTVKLNVITLXNEHERQICREKVGESLAEKVLCIAEAMNRRDYVPKPNQQSDLANVFDVSFKEIQPYLHRMSYQTSDQPASSVGNTMKKMLLDTFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRG1</accession>
    <name>A0A6P8HRG1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC116294652</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558149.1">
        <property type="nucleotide sequence ID" value="XM_031702289.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558150.1">
        <property type="nucleotide sequence ID" value="XM_031702290.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558151.1">
        <property type="nucleotide sequence ID" value="XM_031702291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRG1"/>
    <dbReference type="GeneID" id="116294652"/>
    <dbReference type="KEGG" id="aten:116294652"/>
    <dbReference type="OrthoDB" id="5987799at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00058">
        <property type="entry name" value="beta-trefoil_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056378">
        <property type="entry name" value="Let-756-like_FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558151.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17132" checksum="3F8F6D017396F151" modified="2020-12-02" version="1">MTMDKQSDSVPYLPSRSTSTYSRKRRLYCTNGLYLEINHNGRVKGTMNEHSPLVVMEIVPAGTNLVCIRSVYTGLFLAMSEGEVYTTKTENEECVFKDTLSKQFCDNYMSKKYLSKKLVIGLMRTGSVVAVPANSAKDTTKYATQFITKLPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRH2</accession>
    <name>A0A6P8HRH2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555282.1">
        <property type="nucleotide sequence ID" value="XM_031699422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRH2"/>
    <dbReference type="GeneID" id="116292159"/>
    <dbReference type="KEGG" id="aten:116292159"/>
    <dbReference type="InParanoid" id="A0A6P8HRH2"/>
    <dbReference type="OrthoDB" id="10302383at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555282.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14684" checksum="2EDEC58E8952B069" modified="2020-12-02" version="1">MWNTTDRKEILSVSWGIRKGNIPDPQFISVNGYHRRVTKNKDIGETLKRRVGFIGNLTMGRAWFVLKNLIVNDTNEYIASISDDVSRVLPYYVRLNVTEKEKVTTTEGPFLTPVTTAAAPNITSKALIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS35</accession>
    <name>A0A6P8HS35_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">5-hydroxytryptamine receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17 18 19 20 21 22" type="primary">LOC116294097</name>
    </gene>
    <organism evidence="12 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557522.1">
        <property type="nucleotide sequence ID" value="XM_031701662.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557597.1">
        <property type="nucleotide sequence ID" value="XM_031701737.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557669.1">
        <property type="nucleotide sequence ID" value="XM_031701809.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557746.1">
        <property type="nucleotide sequence ID" value="XM_031701886.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557820.1">
        <property type="nucleotide sequence ID" value="XM_031701960.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557890.1">
        <property type="nucleotide sequence ID" value="XM_031702030.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557968.1">
        <property type="nucleotide sequence ID" value="XM_031702108.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558039.1">
        <property type="nucleotide sequence ID" value="XM_031702179.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558113.1">
        <property type="nucleotide sequence ID" value="XM_031702253.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558186.1">
        <property type="nucleotide sequence ID" value="XM_031702326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HS35"/>
    <dbReference type="GeneID" id="116294097"/>
    <dbReference type="KEGG" id="aten:116294097"/>
    <dbReference type="OrthoDB" id="5959645at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="36"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031557597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031557820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031557890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031557968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031558039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031558113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031558186.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37200" checksum="2802A197059729E2" modified="2020-12-02" version="1">MNGTEPPDVSKSRALSTSDIILVSYLCLVIVTALFGNALLGIVIIKKSLLQNVHYYFILNLVVANFLNALLKIPTSILIRVDKDWYPHYGVCYFTTPLGVLFGSASVGTLATVAINRYLVIASPFSYSDKMPPAFAKTILAGIWIGALGLAIPPTTWRSKDSICSSGGVSSEHKLSEILYFVLALWMFVIIIPSIVMFMAYFKIYLIARNHAKRMEAQQTPALTHTDQQTKKRRRDLKAAVVLAVIGGIFIICWLPFFVVQAIHKFGGHKLNPIYFNVFLCIMYTNAALDPLVLLFFNAEMRVAFVRVFCKRLIRVRPQSGGNTTCGHASAVIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSC4</accession>
    <name>A0A6P8HSC4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116294596 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558088.1">
        <property type="nucleotide sequence ID" value="XM_031702228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSC4"/>
    <dbReference type="GeneID" id="116294596"/>
    <dbReference type="KEGG" id="aten:116294596"/>
    <dbReference type="InParanoid" id="A0A6P8HSC4"/>
    <dbReference type="OrthoDB" id="5979008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22826">
        <property type="entry name" value="Gal_Rha_Lectin_LPHNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027567197" evidence="3">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="33"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558088.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48327" checksum="8DB2EDC365B9016E" modified="2020-12-02" version="1">MKNRVYSTLFFLLFWFGVLFSVAEAFLIKSRYACQGDKLRIRCKSSLIIRIFSANYGRTEPGSSICPNVNTTYTTCKSSKAMDIVTNRCTNKARCNIKADSTMFPDPCPNTFKYLDVIYGCVPRPATMTTAAPRKRHKHKTKPRYQATTTAEWLTDYETTTQSTTTKTPIKTTMSITTSQSTSTRKTIKTQMNITTTIGTNLSIAASRNPTPSAEVKKTNVDPTPTSMHSTTSPPPKQAKSGYIQRGEKEFLINLVVSLYLTYVILSGQPKYVLVLFLSGVAIATVLLLVLLLGLHLKGRRTKKFVVQREDELEPNDEADDEIEEDVSDDENKNITIQIQGEDEETKQISVKPGDIIIIDSKDNVDNDDSEDLGYMSEIVRYYNSRNMVQDDGKQSLTCETPSVNSIPNSEVGDKREPQYDDVPKDNGVCVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVJ2</accession>
    <name>A0A6P8HVJ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional peptidase and arginyl-hydroxylase JMJD5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560429.1">
        <property type="nucleotide sequence ID" value="XM_031704569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVJ2"/>
    <dbReference type="GeneID" id="116296538"/>
    <dbReference type="KEGG" id="aten:116296538"/>
    <dbReference type="InParanoid" id="A0A6P8HVJ2"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000066">
        <property type="entry name" value="lysine-specific demethylase 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF35">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="121"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560429.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51210" checksum="D9BBE60F1493D389" modified="2020-12-02" version="1">MKVSNYNLLILGAIWSTIFITIQSVPNGHLEPLGSHRPKEGSVASLDNVPFPRDFYYNYVLTSTPVIFRGAAKLSKGFKLWSDGYLREHYGNEMVRVDYGKKENRDRAADEMPLAEFLSFYNTSDRYLIDTLPTAMWKEFSLPRCLLCGGFTDALQDSVLWFSSGGTKSHLHNDKVENINCLLSGEKTWFFVDAENSKRIEMDHKEGEYCSVNVDSVDMYKYPSLQVIPWWSAEIKAGDCIYVPYGWAHQVNSLSRNLAVNIWWSPGIAFNDTECEAPLQRELNNFHFTHGEMLRFQAIQIINEHGGAISFEQINALIVHEHTGERLITRERFALLDNNSDGVLAEEDLRKLSTDIIEEAFGGTPPGEVNVIGKSVIRDQVLTDLLSELPEQPPHIEEFLLRPDKLPQEIETFLEKHNRELPKELNEYLKMKMTATKPNKDNEHYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVX2</accession>
    <name>A0A6P8HVX2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Soluble interferon alpha/beta receptor OPG204</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116293493</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with host IFNA1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556785.1">
        <property type="nucleotide sequence ID" value="XM_031700925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVX2"/>
    <dbReference type="GeneID" id="116293493"/>
    <dbReference type="KEGG" id="aten:116293493"/>
    <dbReference type="InParanoid" id="A0A6P8HVX2"/>
    <dbReference type="OrthoDB" id="5966846at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:symbiont-mediated suppression of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF44">
        <property type="entry name" value="X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0244">Early protein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="5" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="9" id="KW-0922">Interferon antiviral system evasion</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0899">Viral immunoevasion</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027703656" description="Soluble interferon alpha/beta receptor OPG204" evidence="15">
        <location>
            <begin position="22"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="120"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="203"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="317"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="16">
        <location>
            <begin position="481"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031556785.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="70759" checksum="3C301EF772EF76DD" modified="2020-12-02" version="1">MIKQLIMVVSFCLLVIPGSDMIICKLNAPSGASNGVWPGSVMVLNCTILQDGPVEYITWKKDGDVLRNTSIVSPGQSLLMWEALKLEDLSDKDDGQYSCVAVKGIHSQEDWYTLNIFAKPHIIPIGLTELELRYGDRFSVTCSASGWPKPNITWTKHGNKYMESSHVLKSPYGLKLQFLFARLTDKGLYACHANNTIGSDLWPVLVKVKPVQFHMRSVKVTTPYKRITVYENQNISLECRASDIDNKHFASFWKHDGKSLTDPERKSKVEVANHLVLWYKIVNVTLKDAGSYTCGVQTDMGEDNQVIGLNVKRRGPPRVSSKNPTIFSKLGSSATLSCTLQYADIADVIMEWTQNHSQWFYTHSRYYNIEHKDPRNGNIIYSLVIRNVTVKDLGCYNCDVKTSLGSCSSTVCLQLKQTKKEIMTIYASSSAGPLWKTTVPVFLVCLVVCVAGFIAGFYARKNRIRRPGFQDNSGPRATDGYQYDVFITFSSKDFLWVKTELIPLIEKHNLNYCIHNRDFQPGKNIVDNMADSVYNSRRILAVLSKNYMSSTFCRGELDMALCRNTLRNDSSLIAIRVDEIEKKRLPKALQGNTFLDYYNDQEKNLWEIRLAKQLALKEEEENTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWW0</accession>
    <name>A0A6P8HWW0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295989</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559811.1">
        <property type="nucleotide sequence ID" value="XM_031703951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWW0"/>
    <dbReference type="GeneID" id="116295989"/>
    <dbReference type="KEGG" id="aten:116295989"/>
    <dbReference type="InParanoid" id="A0A6P8HWW0"/>
    <dbReference type="OrthoDB" id="5979109at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028430077" evidence="2">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559811.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39683" checksum="3B7327CB0591B50C" modified="2020-12-02" version="1">MKTNNVFFVFLLSSFFIYSEAVEVYKVGTNGKPSWRETSEMRDRSNVPTPSQKDVDDYRRRSRIPVPVVTNYRSRSSDIPKPSREDVLADYYRRSKIPIPINSKFRKRFQVPVSQLERTKSGTHFKTQSRRAANRHSSLLQKKNIIDSIFFTIPFGAQFPIYFASKSKKGASKKSNVASPVQRSRAPNRLQTWRLPINYQVMNNKRYFTPFVENQAIARQHIIPAGALAYNRGYSRPRSFTYPRLLSNRNLVPYSSYRNQASTVPRQLQTFLNRRVRRGIGLKRSKLSKGWYHCEQQQQNNKDNDNDNECKDIIQQEQTQTAAAAAATTTTKLKHTEIKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXX5</accession>
    <name>A0A6P8HXX5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116294130</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with JAGN1. Interacts with TMEM41B. Interacts with SVEP1. Probably interacts with PEX11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557525.1">
        <property type="nucleotide sequence ID" value="XM_031701665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXX5"/>
    <dbReference type="FunCoup" id="A0A6P8HXX5">
        <property type="interactions" value="2707"/>
    </dbReference>
    <dbReference type="GeneID" id="116294130"/>
    <dbReference type="KEGG" id="aten:116294130"/>
    <dbReference type="InParanoid" id="A0A6P8HXX5"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="5 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="17">
        <location>
            <begin position="343"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="19">
        <location>
            <begin position="613"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="18">
        <location>
            <begin position="818"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00024791"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057585"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00062633"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00073979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031557525.1"/>
        </source>
    </evidence>
    <sequence length="1224" mass="137564" checksum="D64B2CE6D666A1FE" modified="2020-12-02" version="1">MLTKFETKSARVKGLCFHPKRPWVLASLHNGVIQLWDYRMCTLLERFDEHDGPVRGIHFHDVQPLFVSGGDDYKIKVWNYKQKRCLFTLLGHLDYIRTTFFHHEYPWILSCSDDQTIRIWNWQSRTCICVLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDMSGLRKKTVAPGASGLDDHLKSPGHTDLFGQSDAIVKHVLEGHDRGVNWVAFHPTMPLIVSGADDRQVKLWRMNDSKAWEVDTCRGHYNNVSCVLFHPRQELMLSNSEDKSIRVWDLSKRTGVQTFRREHDRFWAIAAHPTLNLFAAGHDSGMIVFKLERERPAYAVHGNTLYYVKDRYLRIYEFGTSKDVPVMQFKKNSSRTPVYSLSYNPAENCVLVCTNATNPENCVYEVHAVPKQIDSSNPEVSEGKRAAGLTAVWVARNRFAVLDRTHTLLIKNLKNEVTKKVTTPNCDMIFYAGTGSLLLRDPDSITLFDVQQKRSLASVKISKVRYVVWSPDMSHVALLSKHIVAVCNRKLECLSTIHENIRVKSGAWEESGVFVYTTSNHIKYALTNGDHGIIRTLDLPIYITRVKGSSVYCLDRECKTRVLGIDPTEFKFKLALIHRKYDEVLHMVRNAKLVGQSIISYLQKKGYPEVALHFVKDEKTRFGLALECGNIEVALDAAKALDDKACWERLGAAALRQGNHQVVEMAYQRTKNFDKLSFLYLITGNIEKLQKMQKIAEIRKDMSGQYHNALYTGDVEERVKILKALGQGPLAYLTAATHGLTEDAEDVKSTFELNPDTLPQVNPNAKLLQPLVPILQNEGNWPLLTVSKTFFEGAMAAKAGGASLAAVDDVGEAAAEGWGEDAELIIDEEGGFGEDEGIEGVGEEEEGGGWDVGDDDLELPADLDVGPVVPSGEEGYFVPPSKGTSQAQVWCNNSHLAVDHILGGSFESAMRLLHDQVGVVNFEPLKPLFMLAYSRSRTAIIAGPALPNLFGYPHRNWKEAGARNGLPAVGLKLNTLVQRLQAAYQLTTGGKFQEASVKLQEILLSVLLTVVDTKQEVSEAQQLLGICREYILGLQMETKRKTMPKSNLEEQKRVCEMAAYFTHCNLQPVHQILTLRTALNLFFKLKNFKTAGSFARRLLELGPRPDVATQTRKVLQACDKNPTDAHQLQYDEHNPFSVCGLSYKPLYRGKPQEKCPLCQTSYCPEFKGIVCEVCKVAEVGKDTIGLRISPIQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXZ4</accession>
    <name>A0A6P8HXZ4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116296352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560221.1">
        <property type="nucleotide sequence ID" value="XM_031704361.1"/>
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
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    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031560221.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="10038" checksum="10906F2DCB230F0C" modified="2020-12-02" version="1">MVMPVNKPKILKKRTKRFIRHQSDRYKRVGESWRKPKGIDNRVRRRFKGQYLMPSIGYGSNRKTRHLMPDGFKKFVVHNLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0E8</accession>
    <name>A0A6P8I0E8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-phase kinase-associated protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558342.1">
        <property type="nucleotide sequence ID" value="XM_031702482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0E8"/>
    <dbReference type="FunCoup" id="A0A6P8I0E8">
        <property type="interactions" value="2053"/>
    </dbReference>
    <dbReference type="GeneID" id="116294818"/>
    <dbReference type="KEGG" id="aten:116294818"/>
    <dbReference type="InParanoid" id="A0A6P8I0E8"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558342.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52808" checksum="62C114EDB1EBEF04" modified="2020-12-02" version="1">MAPKKQYSRTSDRYKRTRKALKDSRKRRNTLPSGATKYTWGMNESETEEFFNDLDVSVLRWPDEDVRDSSQDQELVEAEDLNGKTTSNNLGQQVSKNNSTKSRILAKKQSKSCGICGHHRQVNHSNAKRKENTEKLDPFTILSDEMILGIFKFLPRHTLSVCAQVSKQWQIFAYDESLWRCVDMAKTKLQPGILGSVLLRGVRVLRLASSMVCSPIFDDNLNIFPDIVPVCQTSDCPLKLCYLDATLCTFEENSLLCLLMHSRRLICLSLDSCTLSLSILRAIGQCQDLRKLNLAMCTGITLQGMKALVNGCKRLTELNLAWTNLGKESILQVVQNLPNLTKLNLSGCRVCLTDEAVLQLVQNCPKLTHLDLSDAIQITALSLSSIAKNLDLQQLAISRCYSILPQAFHLCTQMKSLEKLEVYGILNTDGVDLLKKELPGIKINSCLFSTIARPVSYKYDGTIWGITCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0R8</accession>
    <name>A0A6P8I0R8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.99.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC116297991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>choline + A = betaine aldehyde + AH2</text>
            <dbReference type="Rhea" id="RHEA:17433"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15710"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031562194.1">
        <property type="nucleotide sequence ID" value="XM_031706334.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562202.1">
        <property type="nucleotide sequence ID" value="XM_031706342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297991"/>
    <dbReference type="KEGG" id="aten:116297991"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008812">
        <property type="term" value="F:choline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011533">
        <property type="entry name" value="BetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01810">
        <property type="entry name" value="betA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002550">
        <property type="entry name" value="PRK02106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031562194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031562202.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="66662" checksum="A97C05DA5013BE34" modified="2020-12-02" version="1">MALLRLHNGSRSIADKLILRNIIYKGVIHPHSNSRNSITTFSSTHDYVICGAGSAGCVLANRLSADPNNDVLLLEAGPRDWTWKIHMPAALIYNLCNDKYNWFYHTVPQKNLNNRVMYCPRGRVWGGSSSLNAMVYIRGHAYDYDRWESEGAKGWSYADCLPYFKKAQTHELGADEYRGGDGPLHVSRGKTNNPLFSAFLQAGQEAGYPFTEDMNGYQQEGLGWMDMTIYKGMRWNTANAYLRPIKRKRRRHLRTETRAFITKILFEGNRAVGVEYHKDNQIRRARANKEVILSGGAINSPQLLMLSGIGDGDELKKHGIPVVCHLPGVGQNLQDHLEMYIQQACKKPVTLYSAQKLWNMIPIGMKWFATRTGLGATAHLEVGGFIRSKEGVPHPNIQFHFLPSGIIDHGRTAIDQHAYQVHVGSMRSQSKGSLKLKSANPLDHPIIDFNYMSTKEDWDEMRACVRLTRELFQQKAFDEFRXEELSPGKNVQTDEEIDEFVRNKADTAYHPSCTCKMGESSDKMAVVDNEARVFGIERLRVVDSSIMPSIVSGNLNAPTIMIAEKAADHILGNPMLPKSNAPVFKTPEKGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I106</accession>
    <name>A0A6P8I106_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116295007</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116295007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558565.1">
        <property type="nucleotide sequence ID" value="XM_031702705.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116295007"/>
    <dbReference type="InParanoid" id="A0A6P8I106"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="9">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558565.1"/>
        </source>
    </evidence>
    <sequence length="898" mass="101628" checksum="87F951400D5B6E25" modified="2020-12-02" version="1">MLEVEKKGNDVQMASEDKNRKTDVDKQESTSGDEXKSRSLYSLVIPWKPSNGDLTGTHIVYLVVLLFCVTSASLLSIPVIENILXDKSFVCNDGKADCLVKLSHLVTFRIGIGSADFFFIMMVVLFKAGLTSCRSGLHTGVWIPKSILFILIGYIMYMVPHNIIDTIWGYQVIAAWFIFSIIQLAFLVDFSRAFSKVLRLQNSSENPSFILLKVFTASLIALLFSVVGLIYILFGFKDNCRTNWILTTINVIICITLFVISFVISKNKGTSNIYQSLAQTGLVAGYVLFLTYSAVSHEHSLCTPDIFRFFDSASRLGQYIHSLIGTLVTCMLLSYVTLRSSEPNHFKFNRIXITNQLESDPQLDDLEKPKELYSFSFFHFVLMLASLHASSTFIAPHEVDTVTKATMSWIFLVAKSLASVLVALIYLWILVAPTVYPEENTXEFFTLLKSLFKFIGKSLYTLFFNGCSGINRSISTRFIYTFFFICGTITCTLMYLPGVRHSLQTNSFFCKKISKLGNCMSHDPGYLAVYRICFSMATFYLLFAIVLYAVRTYADPRAMIHNGLWFVKFVLFFGLLVCTFFIPLEFSRVWTYTCPIGTFFFIVVQMILTVDFTRFLNTVMSNRFEATGNKVWFRSILVATISLYVVSFVSVVCFYIYFVGDAGHCKTNKTFITMNFILCGIASVISIHPVITDTGLFQAAAVTFFTMYLTLSGLSYNPNERCNPLASYVSEVDMRPSINVQAIIDLVLTVLLLVYFTLRIVPISSNLRKIAVMSLHLICGQRGQLKTNDSEKNDEMKPQASHNRNADDERFSENEAGDPVPYSYSFYHFVYFLASLHVTMVLTNWYTPKNGTQFKLYINWAAMCIKMTASSLCILLYIWSLVVPILASHKSEPTTNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1K1</accession>
    <name>A0A6P8I1K1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561381.1">
        <property type="nucleotide sequence ID" value="XM_031705521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297304"/>
    <dbReference type="KEGG" id="aten:116297304"/>
    <dbReference type="InParanoid" id="A0A6P8I1K1"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="76"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561381.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44389" checksum="26B152A6C3723490" modified="2020-12-02" version="1">MVLXRKPKEQTISLAMAETVDYIFYGGAILTMDDDCPNPEAIGFKGKTIHTVGTKDHVFSFTGPHTKYVVLKGSQTLLPGLIEPHQHPTLMIEPRCSFVSCSGYHYDSYKQIEEVIKKTVAGVDPTSGKWCVFVGWDPLIVSDLPQLNLETLDAFSLDVPILVISESRHESWANRKAFEAAGIDESADPEGGCFVRDEVTKKLTGKLLEPSAWQAFLSRASKPTIKEIAQAVDDQWKEYACAGFTTVAELLHAPDEEIDRAVRNKAGQPDCPIRLAIYEQISNSEDASKIKPSAICPDKNDLALNDKLWFAGVKIISDGSPRCGSCATREPFLXNEKTENFGFLPSPSYGSLNYTNEELLHMVQQGHNRAKQIAIHAHGERAIEQVLNVYEKVTEMLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1W7</accession>
    <name>A0A6P8I1W7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116297443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561526.1">
        <property type="nucleotide sequence ID" value="XM_031705666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1W7"/>
    <dbReference type="GeneID" id="116297443"/>
    <dbReference type="KEGG" id="aten:116297443"/>
    <dbReference type="InParanoid" id="A0A6P8I1W7"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="2">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561526.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21159" checksum="9C7FF485AE90AD86" modified="2020-12-02" version="1">MLMLFCILHLTYTAVFVFLQNDNKINVIHSVMVHDAISRPKILLDQFREGLNTLGFSDQLKKHPDIFRQLFVRDDASITYDELVQCLCFPSLMDEDETSTHNFLKEFLQKASNETLSNFLTFATGAPCLPNFGLGTIEVKFESTESIFASTCLQHVTFPKQFPDQATFRTVMDSVLNTVAKSFTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2I6</accession>
    <name>A0A6P8I2I6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116295410</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559065.1">
        <property type="nucleotide sequence ID" value="XM_031703205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2I6"/>
    <dbReference type="GeneID" id="116295410"/>
    <dbReference type="KEGG" id="aten:116295410"/>
    <dbReference type="InParanoid" id="A0A6P8I2I6"/>
    <dbReference type="OrthoDB" id="5953547at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="92"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559065.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31115" checksum="D115B9CD8C4D47CD" modified="2020-12-02" version="1">MKENQEARRVFIPWFALFISLACIACLVHVQWTLYTHREQIGFLMKQNEELRDLKQQLLEQNKQTKVTFPFSVICGAINFELLSLTGFLISTILSLPGNEKYLKALSRLLSPVLKNPSTSRWVRCWHAATDGWDVTKTFHPQCDGKGPAVTIVRVGSYVFGGYTEMSWHSNGHYFSSTKSFLFSLFNVKGFNPIKLPLTGNNNKYAVYWGKGYGPTFGNGHDLYISNHASSNTGSYTTLITYKLPPGCSYNKKCIFFTGSSSFTPSDIEVFYEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I357</accession>
    <name>A0A6P8I357_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116295555</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="RefSeq" id="XP_031559260.1">
        <property type="nucleotide sequence ID" value="XM_031703400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I357"/>
    <dbReference type="FunCoup" id="A0A6P8I357">
        <property type="interactions" value="1457"/>
    </dbReference>
    <dbReference type="GeneID" id="116295555"/>
    <dbReference type="KEGG" id="aten:116295555"/>
    <dbReference type="InParanoid" id="A0A6P8I357"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000210">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
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    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
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    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1021"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="128"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="804"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1088"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="412"/>
        </location>
    </feature>
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        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="412"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="413"/>
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        <location>
            <position position="528"/>
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            <name>ATP</name>
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        <location>
            <position position="551"/>
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        <location>
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        <location>
            <position position="662"/>
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        <location>
            <position position="664"/>
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        <location>
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        <location>
            <position position="778"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I492</accession>
    <name>A0A6P8I492_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="22">A disintegrin and metalloproteinase with thrombospondin motifs 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116298940</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563384.1">
        <property type="nucleotide sequence ID" value="XM_031707524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298940"/>
    <dbReference type="KEGG" id="aten:116298940"/>
    <dbReference type="InParanoid" id="A0A6P8I492"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027715457" evidence="19">
        <location>
            <begin position="22"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="20">
        <location>
            <begin position="220"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="15 18">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="328"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="345"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="525"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031563384.1"/>
        </source>
    </evidence>
    <sequence length="1209" mass="135221" checksum="111D37A65A9821BE" modified="2020-12-02" version="1">MGQHILLVVVYLVSNFVLLKSQQTPDLNLHSFMTNEEMAHYLETKSRDDIPEYDVISLSPHKTKRSTHQDDDKXIYKMSAFGKDLLLDLRQTTSSIRPSGILVQQRTKDGRLKVEVYKPEGNFFHGHVVSDPGSRVALRETGDKGELSGAIFSGDHVYKVEPINENLKQKASLHGNGHHVVSRRSIDQRLNRMEPIEVQGMPKINSHRSKRRVNTPLKPKVVELMLTADRPTYEFYGNRTMSYLVNLANMVNRLYRDASMGFNISVVLTKIFIIQGIEPGLDYKTLNIKSAVAYLQKFASWGSKHSFRLPAAAPGHFDNAALITRRLCGTVDCHLGGVAYSGYPCNRNLGFSVNYASGLQAAFSVAHEMGHNLGLGHDHKECAGGFIMSAGKPHGPNAFKWSHCSARDLRAIMSRTKCYDDMPAIRVPMPKYPPGYLYDMDKQCKMVFDSSVSSCPVMKENCGLLFCLKGSYCFSHSSPPLDGTPCGKRKWCMRGKCVAVGNGLPPSVDGHWSDWQHFTPCTRPCGGGVRYRVRYCNNPSPQYFGKPCVGQDKGEEEICNPQECPTPSDPRKEQCIKKGRKHSYYHSPSPCVLYCIHGQFARGHGYVTDGTPCNPNKDNKDVCIRGQCRRVGCDNVLESENPYDRCKKCAGDGNSCRRISLKYTKNYTVYGRKKPDVMFTIPVGAKEVMIKELRNTLNFISLKLDPAPSSPFLFRVPSLTTTINAAGTVIKHYMTDYTSEEWIHIQGPTTQPLYAMFIYGGKTPNPGISCIYVVPGKGRKTQYVWKVSRGNKCSADCAGGEKKHIITCHRQDDGTAVGIRFCDQNTKPPSRESCNTHPCAPVWKVGDWMMCSKSCAGGQERRSVQCQQKVAQDTYVILPDSSCHQPQPSSVKPCNTHQCPPYWKKGQWSKCSAECGGGTTNRTVTCEQTLLNSSIVSLNDVKCLKEIGLKPAERKDCNTMDCHVWDIKYSCKVCTATKGYYHVGCYGDKSTRALPTLLSAYLQGDVITNCYELAKRKGYKIFGVQNAVECWTSRTGNDTYDKHGTSTLCQNNRGGPWANDVYNIVQEKDYIRIGCFKDKHIKAKRPLPKLLDNLRDHIDWKDISKTIEECSEDAWRNGLPVFGLQYYGECWSGPLGHKSYDIDGPSGGCWEGVGTSGANYVYAFSRKVVRPTITCRHVVRSIKVPDSQCKTTKPKPELRKCNEVCKTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4D7</accession>
    <name>A0A6P8I4D7_ACTTE</name>
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        <submittedName>
            <fullName evidence="7">Transmembrane protein 17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116295836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559650.1">
        <property type="nucleotide sequence ID" value="XM_031703790.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4D7">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="GeneID" id="116295836"/>
    <dbReference type="KEGG" id="aten:116295836"/>
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    <dbReference type="OrthoDB" id="311720at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF6">
        <property type="entry name" value="TMEM (HUMAN TRANSMEMBRANE PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031559650.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23595" checksum="BC8B74D39D50363C" modified="2020-12-02" version="1">MAANFGQSLRSAVTSVTETXFPMSRSIRDYPRHQLINDGNELVSDLSLQMALYFNAYFSPFWFLTAVVMLVAKYDSLNFYYKFLLIAIYIVMAIVEMTRLYLGYIGNLQERVPELAGFWLLTLVLQLPLTFVLLLNESMLIMPTERAMNILMALFVVFETLQGYRAIKTLTGNQVSKFHLHQFDEMTEMQDIQERGPEEIGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5C9</accession>
    <name>A0A6P8I5C9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559965.1">
        <property type="nucleotide sequence ID" value="XM_031704105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5C9"/>
    <dbReference type="GeneID" id="116296142"/>
    <dbReference type="KEGG" id="aten:116296142"/>
    <dbReference type="InParanoid" id="A0A6P8I5C9"/>
    <dbReference type="OrthoDB" id="10274672at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028012062" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559965.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13789" checksum="5652D9ED48348FF1" modified="2020-12-02" version="1">MFKELLILAFFVGLASAKIIVKSENDLKKRDSFEPERLSLPKHILEDADVGDPSIFDEKRGADFDKALSIYDYITDLNKRAACTHYFPSLCPTLARKGYCSKAKAGRKAAFVTRFCGWVCNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5X5</accession>
    <name>A0A6P8I5X5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116299470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116299470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563989.1">
        <property type="nucleotide sequence ID" value="XM_031708129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5X5"/>
    <dbReference type="GeneID" id="116299470"/>
    <dbReference type="KEGG" id="aten:116299470"/>
    <dbReference type="InParanoid" id="A0A6P8I5X5"/>
    <dbReference type="OrthoDB" id="2123049at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031563989.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="40652" checksum="D22D6819B20C2D19" modified="2020-12-02" version="1">MKDSVQHGGHVQEDSFQMEIVSTHKLNHNFNTLSVGKPFRYPDFCLITGGDDGTIRVYTTIKDLQSQNFQEISKLESKGGPVQCLHLHNVTKFGSTDLIIGDSKGMLTIFSNEQILNRRVLSHGSITALTVDEDFAGNLAIVVGDDEGTVTAVSPYGSLWKLRLQDACKQMHKQLGLSTSVKCMLSVRLPTSSGAPANYLLVADNCKNLFILQNGMVVFKLQVTSVVTAMSPGYFIPIIPQLFSPSQSFGSPWQQSITSSRQPQVAIATEGGSIYILSNFQLQPYASVQLPVTHLATFPGDGHANGTDFLLCAGHFNALMVFQQQELVKKLDTKEWLHSVLCTNINNEKEIVLGMMDNTVMTYKVALPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6C9</accession>
    <name>A0A6P8I6C9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptide FF receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562886.1">
        <property type="nucleotide sequence ID" value="XM_031707026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6C9"/>
    <dbReference type="FunCoup" id="A0A6P8I6C9">
        <property type="interactions" value="708"/>
    </dbReference>
    <dbReference type="GeneID" id="116298529"/>
    <dbReference type="KEGG" id="aten:116298529"/>
    <dbReference type="InParanoid" id="A0A6P8I6C9"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562886.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="36316" checksum="9FCD563D1A350A29" modified="2020-12-02" version="1">MSNTEHTKILAYQLAQRSPAQVIAETMTLVLIALAALLGNSCVLFVFYKSPRLRTVTNYYIMTLAMSDVAMVIVAMTPTIIVAGSGRNVMGVTAGLVVGFIAYALVFGTLQTTTLIAVNRFFCVVKPLTYRKYFKPKNAIIMIIGVWIFSFSNTAVVYLSGMATSKFFPGRFIYMLAYNDKTTELIFQLTSCIFFIVIPLSLTIICYWKICEVIKGHNDAVSSSFHVGPSGSNSSLSKEEVHITKSVLALVCGFVVCWIPCTSVLFLSTYINLPRHAEMIFTYSTYASSAINPIVFNMFNKPFRSRLVQVLGYKTRRITNVSSVNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6L4</accession>
    <name>A0A6P8I6L4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560355.1">
        <property type="nucleotide sequence ID" value="XM_031704495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296475"/>
    <dbReference type="KEGG" id="aten:116296475"/>
    <dbReference type="InParanoid" id="A0A6P8I6L4"/>
    <dbReference type="OrthoDB" id="7698392at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560355.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36147" checksum="CEB4F0F2F0201432" modified="2020-12-02" version="1">MINLTTQVNENNFMSLIPALKDYFTAKADCFKAGRLVSYLENWKEITSDSEILSMVXGQHIEFNSMPTQGKTPGQSVKNSEVKIIDLEICKLIKKGVILPTGHEKGQYLSPIFTRPKKDGSHRLILNLKRLNMHVEYKHFKMDTLKSAISMMRPNCYMASVDLKDAYYSVSIAESDQKYLKFIWSGNLYKFTCFPNGLAFCPRKFTKLLKPVYATLRQSGHLSSSYIDDSYLQGEDFEDCIRNVLATIKLFDSLGFIIHPEKSTLVPSQRITYLGFVLDSLEMKVYLTQEKSNKLKDACKNILASSNPSIREVSSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7N8</accession>
    <name>A0A6P8I7N8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116297067</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031561077.1">
        <property type="nucleotide sequence ID" value="XM_031705217.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I7N8">
        <property type="interactions" value="1116"/>
    </dbReference>
    <dbReference type="GeneID" id="116297067"/>
    <dbReference type="KEGG" id="aten:116297067"/>
    <dbReference type="InParanoid" id="A0A6P8I7N8"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14061">
        <property type="entry name" value="STKc_MLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000076">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF293">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="104"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="517"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="644"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="774"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031561077.1"/>
        </source>
    </evidence>
    <sequence length="900" mass="100730" checksum="91E83BAD19EF428A" modified="2020-12-02" version="1">MEMYYDEDPSRSTELAGAILTKPDLCIALYDYEAAEEDELSFKANNRIEVLSKDPEISGDEGWWVGRIQSQVESRVGLLPANYVTSDDTPSNFIEPLEISYNEIELKDIVGTGGFGKVYRAIWKDDEVAVKIARTEDYEDPSKTLQSVKDEAKFFSILRHRNILNLFGVCLEIPNLCLILEYARGGALSKALNVHGRKIPPSVLLNWAIQTAQGMNYLHSEAPLSIIHRDLKSGNILLLYPIDENDFNNVLKITDFGLAREIANTTRMSAAGTYAWMAPEVIRASTFSLASDVWGYGVLLWELLTGQIPYKDVEALAVAYGVAMNRLTLPIPSTCPEIFKALMNDCWNQDPHQRPSFKTILEELEEISDSAIMDNQNDSFRSMQDSWKTEIEEIFNELRVKERELSSREDELRKHQMVQEVHADALKKREEELAAREMHLLGREINIIIQQQKQFKPSPKKRKGGFLKFRFGSSRKISAPSDFLHKFTIVSDNDNTIVDCDGATTSPLSPVFHRFRLQSLDDPGPNDPQVPVSPNGHKKKVRTWGPSSVHQKERESRSKRIIVKDSFSSSFSNERCASVPNLGSIINNKDQERKNATAGSSPVSSPKSSRKFPRGKTEKAMCKMGAVLSTLALGRDFTTVAKNMNDVRMRSGSRERRKSPNSRRSREVGRKSWFGGSSSSDITESEGSQRDSIFSSRSFLPDFGRGNGXRPTSTPVMLKSVTYPRNDLNSTAMTIASVASTSXEPLIELCEVRDRRSKSLGAYEFGLVSVNENTSTRTSSFSLNRKSSSSESNGSPRSPPPISPRAINEINSNHVHKHLSNVKGPYSANDGQFEIIGSSTEXVRVGSTNGSGIMTERERLTLLDVNADGQHEDQTQPLLRXQDSARKPYDFQELEKELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7U4</accession>
    <name>A0A6P8I7U4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xaa-Pro aminopeptidase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560770.1">
        <property type="nucleotide sequence ID" value="XM_031704910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7U4"/>
    <dbReference type="GeneID" id="116296816"/>
    <dbReference type="KEGG" id="aten:116296816"/>
    <dbReference type="InParanoid" id="A0A6P8I7U4"/>
    <dbReference type="OrthoDB" id="5951571at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="329"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="7">
        <location>
            <begin position="563"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560770.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="71399" checksum="4D769793AEB7F9BC" modified="2020-12-02" version="1">MTNVTHVRANLVRLRSLMADSSYVGKPLQAYLVPNTDAHQSQYIPQEDCRTHTISGFFAGKATSVVTSNKAVVWTSVLFHDQALNDIDRDNWTPFLNGIPSNPTVDEFLIKELPPNSRIGVNPRYISLDSWKVLNKALSISGHTLVPVSRDLVDVIREEQGIVFKSNQEKFFVLDLKYAGKSWQDKVQEVRETLKRKNVFAIVISNLDELAWLFNLRGRDIQHHFIFYGFAVITPDQISLFVDESKVTDDVRSHLNVDGNRKNEEKVEIRPYEDIKEAVMELNKLKKSVWISPDINSAIGTLMDEERTLMELIPTGRGKAVKNPVEIQGMKDCHIRDAVALCEFWSWLEREIPKGHVTEVSAATQQEEFCKQQNDFLDLSFKTHSFFGDGNPSDSSETGKTITDKGMYFNASGRHYLDGTTNISRVMHYGTPSPWHQECYTRVLKGHIDLAKTVFPTNTTGHALDAFARKALWDIGQDYLLYTGHGVGHVLLVVEGPYCIARVQNPEALTWGRTSYLSLPLQDGMFVTIEPGFYEVGEKFKFRHENMFVVRPAELQNNHRNRGFLKFEAVSFLPFSRKMLIMSLLTKDEIEWLNAYHAECLSKVGPVLKEQGKKEALDWLIAETKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8D9</accession>
    <name>A0A6P8I8D9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide pyrophosphatase/phosphodiesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561342.1">
        <property type="nucleotide sequence ID" value="XM_031705482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297280"/>
    <dbReference type="KEGG" id="aten:116297280"/>
    <dbReference type="InParanoid" id="A0A6P8I8D9"/>
    <dbReference type="OrthoDB" id="5986157at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45778:SF7">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45778">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561342.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="13036" checksum="EA83448B15C7FFBA" modified="2020-12-02" version="1">DYLVSIGMRHMIEDLLYKYKVDLALWAHYHSYERTCPVYKGKCQHGAPVHIVVGTGGKELDLANYLKMDWSMFHMXDYGYGRVTAYNHTTLLWQWIRANDTTLLDQVLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8F7</accession>
    <name>A0A6P8I8F7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aldose 1-epimerase</fullName>
            <ecNumber evidence="13">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116296960</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031560945.1">
        <property type="nucleotide sequence ID" value="XM_031705085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8F7"/>
    <dbReference type="FunCoup" id="A0A6P8I8F7">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="GeneID" id="116296960"/>
    <dbReference type="KEGG" id="aten:116296960"/>
    <dbReference type="InParanoid" id="A0A6P8I8F7"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000003">
        <property type="entry name" value="Aldose 1-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008277">
        <property type="entry name" value="PRK11055.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031560945.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="37848" checksum="1B60F9723A48B6ED" modified="2020-12-02" version="1">MVHVEKSFFGTTKDGKKVDKYTLINEKGVEVEVISFGAVTVAIKCPDKDGKIDDILLGYDTLEGYLSNAPYFGATVGRVANRIANAKFTLDGKEYHLADNDPPNSLHGGWIGFNKVLWEGIMGSDHVTFKYTSADGEEGYPGELKVSVTYTLTEENELKISYRATTSKPTPVNLTNHSYFNLGGQTTKDVLDYMLWIDAESYLPTNEVQIPTGEIRPVSGAPDGALDFRTPKPIGRDINKLTPPGYDFTLCVSNGEGCKARAIHPTNGRVLEVYTDQPGVQLYTGNGLDGNIGKGGLHYKKYSAVCLEMQNYPNAINQPNFPNCVLRPGEEYKQESAYKFLVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8Q2</accession>
    <name>A0A6P8I8Q2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein zampogna-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116299860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564438.1">
        <property type="nucleotide sequence ID" value="XM_031708578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8Q2"/>
    <dbReference type="GeneID" id="116299860"/>
    <dbReference type="KEGG" id="aten:116299860"/>
    <dbReference type="InParanoid" id="A0A6P8I8Q2"/>
    <dbReference type="OrthoDB" id="10288131at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564438.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="29351" checksum="5FDC85ED7EF688A2" modified="2020-12-02" version="1">MYQAIEVDVSSKTKPLNKKASFMVEDLLRSTHTSSTDTNDCSPSQQLNTERHCKTSSGRSWTKEDSRSTETSPNYCTSTRDESTHCHQDDSSPVSSTSNTAAALSNDQQHHLEKVFRLQRYLGTKERQRLAATIRATDQQVKMWFQNKRVTLKLQIDKAQHRQAKLAYLNSLAQSLLNTTQQPSLPQTVVKPSVRKCFSLSSRHIPYRNYDDQLSSRYSRPQRVTPYSWNQNRYRLDWVPNVVHYHPQVVPYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I956</accession>
    <name>A0A6P8I956_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116300369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-malonyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11878"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87831"/>
            <dbReference type="ChEBI" id="CHEBI:87833"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-100 and Arg-103) that bind to malonylated and succinylated substrates and define the specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031565089.1">
        <property type="nucleotide sequence ID" value="XM_031709229.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565090.1">
        <property type="nucleotide sequence ID" value="XM_031709230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I956"/>
    <dbReference type="GeneID" id="116300369"/>
    <dbReference type="KEGG" id="aten:116300369"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="273"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565090.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33598" checksum="2A603822B665145B" modified="2020-12-02" version="1">MICRRLFQVRLGRLLSKASFKPRMAESQLHTSGPSSNKKNFQAHLSKASNVLFLTGAGVSAESGIPTFRGAGGYWRTYQATDLATLEAFYQNPSLVWEFYSYRRKVVLSKKPNPAHIAIAEFQKRYRDLGKQAWVITQNIDGLHQAAGAEDVIELHGALFKTRCLKCGHVEENRNSPIVPALFNKGAPDHDAKDAAIPLSELPRCNQPGCDSLVRPHVVWFGEALFDDILKKTSEVTDACDFCIIVGTSSVVYPAAGFAPQLAGRGVPVAEFNMESTPCTGVFSFHFQGKAGETLPPLLKLETQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I958</accession>
    <name>A0A6P8I958_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116297535</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116297535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561642.1">
        <property type="nucleotide sequence ID" value="XM_031705782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I958"/>
    <dbReference type="GeneID" id="116297535"/>
    <dbReference type="KEGG" id="aten:116297535"/>
    <dbReference type="InParanoid" id="A0A6P8I958"/>
    <dbReference type="OrthoDB" id="5953621at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031561642.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26164" checksum="4AACF4062C5E0576" modified="2020-12-02" version="1">MSALIFELNPDKTLQVGCCLTIFNYISQLQELLYYLGSKNSPKKFCRLKLPMSGAAEQSLSPCYRLTPTTEGGLESSTSMSMKMIETRKNGLQKIVSGLERRVVPLQRQKEDLQLVLNTVNNWVQVLNDTQRWNSGVPILRSAKENCDDLITPYLNDSDSDFNQAVFRLGSAEIPGFAQAQKLLKSIRHEIRVIFEKESTFNGKFVEDVRVLMGQVTGIISAILGLYYQTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9G7</accession>
    <name>A0A6P8I9G7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116300052 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116300052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564673.1">
        <property type="nucleotide sequence ID" value="XM_031708813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300052"/>
    <dbReference type="KEGG" id="aten:116300052"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NFX1-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="DNA2/NAM7-like"/>
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    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
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        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1593"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1622"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1772"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1803"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1830"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1855"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1885"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="1912"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="2047"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="2264"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="2294"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="2566"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="2891"/>
            <end position="2914"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="2918"/>
            <end position="2937"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="3086"/>
            <end position="3104"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="3112"/>
            <end position="3135"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="7">
        <location>
            <begin position="3169"/>
            <end position="3186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031564673.1"/>
        </source>
    </evidence>
    <sequence length="3372" mass="383900" checksum="57C54FD48C342AF4" modified="2020-12-02" version="1">MASASEPTKSVAAFNCESHSYVIGKYLSSVPRKKPKYLLLICWILNTTHKKELKELELKDKRDLKEASRSYRSKRKKFGSKTKIKKGNMGKNAKKKESKKKKGKMKSEDNNDTSEEVQYQSVTEDDAVETSTHQLSVTTQSPKGKFKTSRQRKRAEKEQHMKEEKSSVGKKKTKSQPQQGSGKEKKEQTISEKTTSNKPDESAGCRPASFVTGCLVPENSNPCMYDMYDLRPSYFQAKDQKEPLDQDRYVARQPRNSSIPNPQGIEDLRPPFDPWGDREGDCIDGNRRNPEYQSPNNTSPSWYSKSKTFDVTAINNNLWSQDQDEEPSIDGNWRKVVRKTKKGTVSSSPCKSGLSALGALNKLLPSEIQSVLAKEIHKQLASKEGSQNVCDTFNLLRALAQACEAGKSENLSKILTAIQGSGFLRYQLPAMLKRVQQEAVVLMKESDKRQMISDMIDVYQTYLRRLPSAYADLPLDEVQRYFKKISVPNKAVLEHKLEALKKERDEVIQNKRRRNAKLFKGNAHIKPPNNFRELQIFPTIYELTSDETTFLRANVKKGRYQDTEHYLDVQFRLYREDFIAPLREGIQEIVQKIPKNERGQNIKTYDRVQIQEKKYTKNGIIYTLHFDVSRFRRTRWESSNRLVFGSFLCLSKDNFANTLFATVANRDPKDLAKGLLDVCFIEGQNVYGIEKRQMDQYVMAESPAYFEAYRHVLTALQSMHEECLPFQKYLVECSKDVDAPAYLRDKKEPVRYDLREALEVPHVQEAADVALLQPDQWPNVSHLPLNDSQYEALRTALTKEFSVIQGPPGTGKTYVGLKIARCLLTNSHAWNPTQDSPILMVCFTNHALDQFLEGILDFMPKGIIRVGSRCKSERLEKCNLKNDVNIRKEERLGTKKRIEKQLRRVETKKLALKRYEDDDGIKKLQILENANCISHNHLDGFYYSNLYDRECETLQDVFEAWICNKSNRRRKAVLKEVTPKFKDNYKEPSQQEAEMETTEYDATPYIFLADEDDWGVADSDVDIPGPDSFIDENSDEDSEDTWEDANSDLESEEEYFECSAAVNGDEVKERREGNKKAEEVLVISEKNRAPETINIDREFEISRQLHGEEDLFQPICASLDRSDNDVLQSGDETPCQDIRYQDIDDSFESSIKMQKEIEMNANQGWELDTQYEGTKKKKKKKSKSTASKATPSNIRRAKAKMARLKTMTEEEIAKMSSIWDLGHDDRLRLYLTWEDMLKEDFKLKIIQEEQAYDGLCREVESVRIVEEEKILKKAKVIGMTTTGAARYHSVLQRIKPRIVIIEEAAEVLEAHIITSLARDTEQVILIGDHKQLRPKPTVHELAIKYNLEISLFERMVLNKMDCKMLSIQHRMRPEIAQLTKRIYKDEIYDDVSVTMFEDVRGMKTNLFFLDHRGVESFHNGLQSYANDHEANMMVAMCKYLLQQDYKPSQITILTLYIGQLLTLKDKMPLEEFKGVRVTVVDNFQGEENDIILLSLVRSNTTGSIGFLKESNRICVALSRARKGLYCIGNFALLSKDRLWKEICEELKRKDALGDRIQLACANHGEITEVKKEEDFKKVISGGCGRPCDLRLACGHRCPDRCHGSDPEHKESKKCRKICRTLCPEELHRCLERCHYPKDCGPCLVPSTKIFSVCGHKGRTACWIDPRTKNCDYLDYKPLPCGHKQDIPCFLDPLQSLQEQYEEAITLLEKLSKICRSQRTVKEYSQLNDEDIMELNEYVIEMAYLKDRSLKIRQNWPKYESALQCKESCTAKCEKGLHTCTRKCHYGEECGPCMVRIKVEIPECGHQAQIPCFKDPDTIYCKAKCQRMLACGHECQQKCGDNCSFLACEMPCPRQCENNHPCKQCCHWGKPCPSCIIPTEKALSNCNHKIRIECHVDISNVDCFQPCERERSCGHSCDKWCYEPCDAFECKARRLKTLPCGHQKVLPCYVDLSTYTCTSLVTKPLPCGHELLMPCDLDPHNHICIEEVTRKLPCGHESKMKCHSDPSKKCCKERVTKKLSCGHELEMLCFQDPSKRQCSTQVMKKLPCGHEIMMDCHSDPLKRKCRAQVTRKLSCGHELEMKCHSDPSKQQCNKQALKKLTCGHLTQVPCNMDISKCTCKTLVPKALPCGHEIEIPCHEDVSQHTCKKEVKKKMQCGHEDLMPCNVDASNVKCTAKVDKPLPCGHNIKVPCIEEDLSKYKCTEKVSTKLKCGHEIQTPCSRKIPKIICREPVMKKMPCGHENSMPCNADPSTRTCTITEDINLPCGHTVSKPCYPSGKIQPTSICCEKVTRVLDCGHEHQMQCHIDPSQFICTKQVEKQLPCGHSQLLSCNMDTTGTVCKEKVIRRLACGHESQMSCNLSPDKYQCLILVKKELKCGHSKEVVCSTSMDAVVCNEITEKKLPCQHSRTMLCFKDVHSVCCEEIVTKELLCKHLKDVPCHRKITDIQCNEEILKTLPCKHEKHLPCYLDPRNANVPCDIVVTKILLCGHEVEVPCSKEITAISCDKPTKIILLCGHEVEVPCNKDMNTISCNKPVKKILSCGHEIEVPCSKNTSTISCDKPTKKQLRCGHKVEARCHVDVSTISCEELINKTLPCQHEVQTSCNKDVNEIRCDILTRKSLPCRHEVEVPCYVDINTIFCQTSLKKQLPCGHEAQVPCQADVTTITCKQPTMKTMPCSHEVIIPCNVDVTAINCDKQTMKTLPCGHEVKERCNVDVKAISCGEIVKKTLPCGHIREMSCSENVREISCTEPTVKQLPCDHKVEIPCNKNISTASCDALTKKELGCGHKAEIPCYKDVSEVACEELIKKQLSCGHEVEIPCNVDTTAISCYKLVMKQLPCSHGEVKLPCNLDISTISCRKSVFKELACGHMKELPCSTDITTVYCDIPVVKQLPCDHEIELPCHKTQEEYICQRPCERLLPCNHQCKQKCSEKCDPKLCTEATSKTVPCPNKHKITIPCNVEVEDTYVCNEEVTKQLSCGHLWQGECSNSTLPFDCKIEVTRTLSCPGEHRRELPCHVDVRKIPCGQKCSKILPCGHPCKLYCEEPCCPDKCTVRVLKTFGSCGHEKWLACGISMKAICLYRCLRPLNGCGHPCQAPCGKPCNKPCRYRVRKTLPCDHKLKLKCCDPVQYVRCPFPCTAKLLCGHICTGKCSTCQEKGEHSPCPFPCGRALVCSHRCHERCSDPCPPCFRECRGWCPHGKCQGNCSDVCKPCNMPCAYTCIHDKCNNLCHEMCDREPCNEPCQKVLACGHPCIGLCGESCPILCYVCTPAKVAAVSPNGQRNKDLRFIQLKECGHVIEVNRMDDWMQEHLETATNGQAQPLRCPICSVPIYFSFRYGNIVREALQRMFEVESFTFQKKSRRRQSQGWTKIPRTTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9Z9</accession>
    <name>A0A6P8I9Z9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine-triphosphatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561495.1">
        <property type="nucleotide sequence ID" value="XM_031705635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9Z9"/>
    <dbReference type="FunCoup" id="A0A6P8I9Z9">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="GeneID" id="116297414"/>
    <dbReference type="KEGG" id="aten:116297414"/>
    <dbReference type="InParanoid" id="A0A6P8I9Z9"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050333">
        <property type="term" value="F:thiamine triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042357">
        <property type="term" value="P:thiamine diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039582">
        <property type="entry name" value="THTPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586:SF1">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561495.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23786" checksum="4D084C71291D3A92" modified="2020-12-02" version="1">MIEVEKKFTVPPSFEDVLARVGAVLVMEKEFLDSYYDFTDFKLSLQDCWLRERNNSWELKHRDKHSKSRSTTTDSYYEVDNEKEILRSVATYVSMDTSVKSVQEFVTGSRLRVFASFKTRRMRYEIDGLFIDLDSASFGYNVGEIEMMVGSKDDIAGAEIKIESLAKRLGINWKTKQHGKLGEYLYLNNPTLFKQLVESKVLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAV8</accession>
    <name>A0A6P8IAV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-1(XIV) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565318.1">
        <property type="nucleotide sequence ID" value="XM_031709458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAV8"/>
    <dbReference type="GeneID" id="116300574"/>
    <dbReference type="KEGG" id="aten:116300574"/>
    <dbReference type="InParanoid" id="A0A6P8IAV8"/>
    <dbReference type="OrthoDB" id="5986259at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027724714" evidence="1">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="33"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565318.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24452" checksum="D0A1AEFB5010E98A" modified="2020-12-02" version="1">MVRLFVAFIALCLINDAFPAPAKHEDLCSAGMDIAFILDARLSSSTWKKTLRMSKKIVDEFGASEDGNHFAVMTFNTEPQIDMKFNKYNGSDLSREKINGDIDGLKRKTGYKFIDRALLAAEKEVFTVEAGMRQKARKVAVVITDGIQTKNRGQFLNLYEASNGLKSKDVEIYSIGVGEDIDVLGLLDMASSEDKVITSGWYILSEFGEFKNSFCYPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB25</accession>
    <name>A0A6P8IB25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116298282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562532.1">
        <property type="nucleotide sequence ID" value="XM_031706672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298282"/>
    <dbReference type="KEGG" id="aten:116298282"/>
    <dbReference type="InParanoid" id="A0A6P8IB25"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031562532.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15467" checksum="11267340A294F3C5" modified="2020-12-02" version="1">MAEGSEQLVSCTSKTKTSQKTINDFLSADGKFAYMRLCSIELCLLFPAKHERPFVKKIFCDLVKSVGLPSEAQSNLVGCLLFDLDADMKDFDEGASKNTVLMIKTLKDECQKQQNLVVIPKDLILFALKXRKLNNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBJ8</accession>
    <name>A0A6P8IBJ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ER membrane protein complex subunit 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564691.1">
        <property type="nucleotide sequence ID" value="XM_031708831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBJ8"/>
    <dbReference type="FunCoup" id="A0A6P8IBJ8">
        <property type="interactions" value="3409"/>
    </dbReference>
    <dbReference type="GeneID" id="116300069"/>
    <dbReference type="KEGG" id="aten:116300069"/>
    <dbReference type="InParanoid" id="A0A6P8IBJ8"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564691.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22043" checksum="C310F65132954238" modified="2020-12-02" version="1">MKYTVSAKAYAKMLLHAAKYPHTSVNGVLLGEEVTQESEMFILDAIPLFHQCLGLAPMLEVALTQIDSYCKASGQQVVGYFQANEHVNSNSPDGIAYKIGEKITDQLANACILMIDNTKMSIACDEVAVRCYIVQENKWKMNDKDLCIDGGEETLSLTSELIEGKAYQSLVDFDNHLDDITLDWSNRDINRLVDLTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC37</accession>
    <name>A0A6P8IC37_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031562480.1">
        <property type="nucleotide sequence ID" value="XM_031706620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC37"/>
    <dbReference type="FunCoup" id="A0A6P8IC37">
        <property type="interactions" value="1562"/>
    </dbReference>
    <dbReference type="GeneID" id="116298235"/>
    <dbReference type="KEGG" id="aten:116298235"/>
    <dbReference type="InParanoid" id="A0A6P8IC37"/>
    <dbReference type="OrthoDB" id="5954453at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16541">
        <property type="entry name" value="RING-HC_RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12882">
        <property type="entry name" value="SPRY_RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000133">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035773">
        <property type="entry name" value="SPRY_RNF123"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057987">
        <property type="entry name" value="TPR_RNF123/RKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25576">
        <property type="entry name" value="TPR_RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="47"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031562480.1"/>
        </source>
    </evidence>
    <sequence length="1173" mass="133107" checksum="C4D8025D0B19D052" modified="2020-12-02" version="1">MDVDQFLTSIFPTPEKENVATPRRLLEYSTLQEHIDDILNHYEDTTQPEQDQRERAMNDGRIGAEIVGIDKNSLCGSMNIKDNIELESQSNFSSVRSSICICKGKWMYEILLGSKGIMQLGWATLSCNFTSEEGVGDTPDSFAYDGHRVRKWNMSTAKYGEEWMAGDVIGCSLDLDEGKISYSRNGKSLGVAFDNVRYGPGVAYFPAVSLSYGESCQLNFGAYPFKFPMEGFKPLQDPPTAIVSKATELMNCLDRLLPSPDRVACLPPSLHGRSDTLSFLTTAHVFEKLGPLLTKGFVVEKVLLPFLLKSCSGGNPLAEQTGVYRMLDLMWACMEDFELEPCLENLLFALIKAYWYQPVTLDFKQQAHCLSLALSILRHHKTRRLWIECKIFPQKFSYFMHIRPPDDDILNAAFPVVWRESNNETSQSATDKEEYLSACQRLKNKVQVLEDVQVEMCKILLQDDDLSTMGTKSTRAMFLDKFMKYLQENMLPTSNLRVQPSTACGGPVITCFYHRLIQALRCHWDDISDQSHSSRPSHGDVYVPFHIFFDGSIQYWDMSRLGGLVSHLKKTNDTAIKEELNKQKSAAFGGNTLAEEDWLQDSSLVRMLDDVILLYHIAVHKQLSKVCAVRDSMQQNIKALEDIEARIKRCPPEREEVLAELNRSRSVFLEETTNCARHMAWVSTLIFTKSKQEDIHWMLRCILKSISRGAKRGSLFEFAPEFYVEVAINAFHGLRNYFHPTTNFFDLPAVYLVFVSSPDATGTLDKMAAFLLTHFNDKRIINPDLRDIVIQALAAFVCYPDSLKAVERMPGDLLESSVRFLLGAYDKRSWVQTTWILVRIWKGCGFAFRYTSSQDVFTSSAFPEQGHLRASLQPPCPSDVLQKLISKLCLSDVKLADEFLNGVLNQLNWAFSEFIEMLQEIQQATNRLEISLEKRQLRTCAVCFDLTVGLLRVLEMVSTVTPQVFTDWKMESSELHIARLFQLLTQVLKRITANSNLFENVTRLHLPGLETVDRFPVLGAVAGILITLLLHGTTESKERATSALLAEPGFTMESVEFLVGGKSSVPSKKSQQSFSFRTLANKDVNQEEVKEVENLVHYLEEQSLQVKLHKQESVDVEELCPICYAMKISVKFMPCGHVSCKSCITRHLMNNKECFFCKELVDRFEDISSDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEV5</accession>
    <name>A0A6P8IEV5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116300163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564815.1">
        <property type="nucleotide sequence ID" value="XM_031708955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEV5"/>
    <dbReference type="FunCoup" id="A0A6P8IEV5">
        <property type="interactions" value="1300"/>
    </dbReference>
    <dbReference type="GeneID" id="116300163"/>
    <dbReference type="KEGG" id="aten:116300163"/>
    <dbReference type="InParanoid" id="A0A6P8IEV5"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
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        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
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    <sequence length="131" mass="14899" checksum="0ED9611FF115AB7E" modified="2020-12-02" version="1">MTHRGSTSGMGSNQGPGFVGIKFCQECNNMLYPKEDKENKILLYACRNCDYQQESDNTCIYVNKITHEVNEMTQIVGDVVADPTLPRTDDHECKQCGNRESVFFQSQSIKADQMILYYVCTSPDCGFKWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFA2</accession>
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        <name evidence="5" type="primary">LOC116300636</name>
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        <name type="scientific">Actinia tenebrosa</name>
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    <sequence length="544" mass="61370" checksum="FB40F8D961E6AF50" modified="2020-12-02" version="1">MSASSKSSIQSFFEAKNHCREAFSVLHEMRGNMELCDVVLKVGNLTLTAHRAVLAATSPFFRREFSSSELDRSNNEFVMPDNIQPESMAAMIEFLYTGSLHINVKNTEELLETACLLKNEEALQAVIESVVASISISNCLRLQGVSRRHNLADMKEKIDRFVEWNFEEIARRKAFLSLEAEQLREILKSENLRVKGEEIVYEAVYKWYMHDRDNRRESAERVFQEVRFCQIPENLLVRQVIPDLVEKENLCSEFVEKAMDHHRDPTKPSRPRKPQESIYVLSRRDSIAERFDPVHGTCIPCYPMVPVDDGDGEHRCTVIVGDDIHAVYEKRVEKYDPVGLCWLGVGPGIDTHDAAVCAGKNCIYVVGGKSHREKVYKFSLKNSKWTELPSMSESRRLPGAVCIGIKLYVVGGFGEKGALFSVECYNTKLEKWTPLKPLNFARFQLGVVSLNNSIYVIGGRDNSDTLKSIEVLGIKTKGWKVLDGQLNEARNDFGLVVQGEEIICFGGRGVKSIESFNVTSEESKVVGNTGISTFSIDCLLFPAM</sequence>
</entry>
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    <accession>A0A6P8IHN0</accession>
    <name>A0A6P8IHN0_ACTTE</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Actinia tenebrosa</name>
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        <lineage>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_031566229.1"/>
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    </evidence>
    <sequence length="512" mass="59124" checksum="D5CED99811427D2B" modified="2020-12-02" version="1">MTSNYPISAKVLFTCYLDLEAQPTKYSMHVETRSSRSSQLHITFVEHSTIIHNGKIQSHLLHKKYSPTITKRLSTTAHRKTEQFLRRXMRWKAHFFLNPSTATSSKDTYGFKSTKNPPPIDELKDFETDMLKMIQSTKFKQVNIPFLNKLKDDTEKIKKEPKLLIAADKTTNFYKLEPSTYNDLLEQNITKSYKKAQPNTTRAMHAENKNIATKLGIDDRVDTTANKDAFITLKDHKPNFANKPACRLINPTKSEIGEISKKILDRINNKITTASKFNQWKNTASVIEWFKSIKNKQHSFICFDIVEFYPSISHDLLNRALDFASTYDNITNDERNIIIHAKKSILIHKQQQWQKKGDTTFAALQWAAMTALKHARLYRDDGLAISNATPRETENIKKDICRIFNNNELRITIEANKQIVNFLDPTYNLNQNTYQPYIKPNTTLQYVHRESNHPPITTSNIPAGINRRLSSLSSDKASFDQAAPPYQKALDESGYQYTLHYESIATTKRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJB4</accession>
    <name>A0A6P8IJB4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116301828 isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">LOC116301828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566820.1">
        <property type="nucleotide sequence ID" value="XM_031710960.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
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    </dbReference>
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        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
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    </dbReference>
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        <property type="entry name" value="FN_type2_dom"/>
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        <property type="entry name" value="Kringle-like"/>
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        <property type="entry name" value="Pan_app"/>
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        <property type="entry name" value="TSP1_rpt"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028051422" evidence="4">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="6">
        <location>
            <begin position="190"/>
            <end position="235"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031566820.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26350" checksum="5E83766B126AE8CB" modified="2020-12-02" version="1">MRMKRGATEFLQISMVFSAVFFVKGQDDCKSMVFFGCVQNKALSGHVIKTLQVSPSTATCPQMCFMEANCMSYNMGPIEGETRSCDLNDADNVLDYLDVVAKDGFEFCTFKNPCSSSPCAAGKVCLPDASWNSFNCSNGRWSQWTSWSSCVCDQTRTRQCVDPFTQQTATDCSGSYEEKRNCKAAGTNTTDGTLCVFPFLYKEVWYNHCTCVDWNHPWCATTQIYDKYAWGNCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJJ7</accession>
    <name>A0A6P8IJJ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Probable G-protein coupled receptor No9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">LOC116301883</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566907.1">
        <property type="nucleotide sequence ID" value="XM_031711047.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566908.1">
        <property type="nucleotide sequence ID" value="XM_031711048.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566909.1">
        <property type="nucleotide sequence ID" value="XM_031711049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566910.1">
        <property type="nucleotide sequence ID" value="XM_031711050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJJ7"/>
    <dbReference type="GeneID" id="116301883"/>
    <dbReference type="KEGG" id="aten:116301883"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031566909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031566910.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38355" checksum="53517CEE4C87C85C" modified="2020-12-02" version="1">MANTSSNITSNSSLSTPTVMASFSKSLSIPSFIFLLFILVMSLSGNILVILAFRIYRKLRTKTNYFVISLACADIFVASTSMPFWGVYLLTGPNSVISDTLMKVWTSIDILCGVASIINLAAISIERCICITRPLTYHTMMTSRRAVCIILFNWFLAFIMSSLKFALYNWEPPKYELLISISCFFLPLTIMCLCYHLIFKAARYQARQIALVVKGGVRNFLLSTEVRAAKTLGVVMGAFIISWGPFFVMNLVYGFCPKGENCLSFEAVMVAKWMHYSNSFYNPIVYACMNKEFRSAFANILFRGRACSKNGPSCRRGTLTECNLTYFHGNANGSSMESCHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKL0</accession>
    <name>A0A6P8IKL0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein pigeon-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567225.1">
        <property type="nucleotide sequence ID" value="XM_031711365.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IKL0">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="GeneID" id="116302141"/>
    <dbReference type="KEGG" id="aten:116302141"/>
    <dbReference type="InParanoid" id="A0A6P8IKL0"/>
    <dbReference type="OrthoDB" id="9997853at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="1">
        <location>
            <begin position="731"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567225.1"/>
        </source>
    </evidence>
    <sequence length="974" mass="111968" checksum="F60E5AEFFCC1FD72" modified="2020-12-02" version="1">MVELNRDFSFKEQVFPLIIQNRSHYRGNEDNSVSEADYDTLKEQIQAHVVGQEKDGTVLVAWDDKSPNGTHKVSYVAEYEASKQKLKVLFIHDKKVKIIGASVNQEKTLLAFTTTEPFYGSLEDPPGTEHPGIYKSFLXEIRPQNRIFSLCVERHTFQRVQFLYGIYLGYGNTSKKESHMLFFHHKKAIGLYHIPMARIGDKGMIMSSQPRTEQVGGPFYWAQWDTLNQRLYFLHKKFKEDDEEEKGSFEWTFSAYQFSEKVLQFCVLNMQLPFNIDTNHVISSSAQYFNLPLMQTISEKQFNMQVVTTAGGSLYICLQHKIEDEEEEEGFHSEQLPLQKRLSSETPPTEQSFMASLEYSVYFLHHDCILHCVLHCVPKHLVKKSVLFFSSLHNYLLVLLPGYALHLLNGNAEHEPCHHIILQGDEIPKFSVQGPEDQPPLLLYLHKQQNTFVVSEPDILDSRSGDGFELNFCKDRLVEIFSKTHLPTTRLSLLHLVLVHIKDAALLKKMIEHLCYDPSSPECTDLLKEYLMGSTYALMKKVLDRDVHRLVPFTCVDTFRGHLEESLDKRRIARIDCTLCRDTCVEFKNDKKKPLDGFWSAVKENKEYAKQQNLRFSLKSLGMCCDEESDEETETSQQQQLSQPQASSVKTLLRRFSSKKYPSMESVTSQTSTKSGDFLEYCEDDRSISEIKKQNMVIDRLAAHFQAHLPRETRTKTHNIAVEYVKNQAAQSDALLRLFRSGLGFSSDTNPTITLLFVRGTIREIALFQMVERYYTSVTDIKFPFPPGFQTFFTTLACRCLNQRMFMQYVDNNVLQLTDQFISRLVDDWDGESGDSDFVFQILSRLKHEKVKQAIQRWDHPLSTRYLSQQIADELLSTDLLECLGDKESLDCGFSPGKEGGLHGSFKESESFSDEEPCFRPLSTLMSTLREKAAHLPNESQFIDGGPYNLKHIEDVALLQTSREVDGSLATVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKN8</accession>
    <name>A0A6P8IKN8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Collagen alpha-2(IX) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistin/FIZZ family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567245.1">
        <property type="nucleotide sequence ID" value="XM_031711385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKN8"/>
    <dbReference type="GeneID" id="116302164"/>
    <dbReference type="KEGG" id="aten:116302164"/>
    <dbReference type="InParanoid" id="A0A6P8IKN8"/>
    <dbReference type="OrthoDB" id="5990555at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4230">
        <property type="entry name" value="Resistin head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009714">
        <property type="entry name" value="RELM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036262">
        <property type="entry name" value="Resistin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06954">
        <property type="entry name" value="Resistin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111423">
        <property type="entry name" value="Resistin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028036943" evidence="8">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031567245.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="32657" checksum="91984261883E2F23" modified="2020-12-02" version="1">MMSTFRLIVILSVFVLIPTSCHCELQGVHQKKGNTSCPPCHPGPAGFKGQKGITGEPGSDGFPGYPGQKGEIGVHGFKGDAGPRGYQGIPGPMGPPGAPGRLIPRGRDGLPGKDGPPGVPGNKGARGAPGPRGDWDHKTMGRTGPIGPPGIPGKDGLKGVKGRRGFTYAAPRGDRGEFGEPGEVGRPGRKGQKGSQLVGMRGDPGIDGKLGDPGQDGAPGDMGPPGVPGKDGSPGVPGINGAPVPIPTLKCIQVKTNGNNANCSAGYKVTGCACGMNCGSWIIQNDFTQCSCNLSCNSGKPLDWTRAVCCQISAVVTGTISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKW6</accession>
    <name>A0A6P8IKW6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116302029</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567077.1">
        <property type="nucleotide sequence ID" value="XM_031711217.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567078.1">
        <property type="nucleotide sequence ID" value="XM_031711218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKW6"/>
    <dbReference type="GeneID" id="116302029"/>
    <dbReference type="KEGG" id="aten:116302029"/>
    <dbReference type="OrthoDB" id="10028716at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016849">
        <property type="term" value="F:phosphorus-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.82.10">
        <property type="entry name" value="ADP Ribosyl Cyclase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF7">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653210" evidence="6">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031567077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031567078.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40500" checksum="672F0742F6518B04" modified="2020-12-02" version="1">MSAKLCGWLFIFFKLTSEAAVCGSESMVSQDDSFSSIKNLIFHKLENQIERLSSSDPSSSDNEAFVRSKIQKYYYLRSGKQKMSWMYKPTKGTTRHLREIFLGRCWDFVENKNANLVEPENINCDVLLTSFLKAFSYKSPCEVKKEDYRDFFNHFREKQLIDKVLLWSGTREWTHAYSGLFNKYVTLEDTLPGYVLNGLSWCGSKSWPGIDYKSCPYECVKQKAFWGLAAAKLAKRARGVVYVMLNGTRQHLIDRQIFPAFMEDSYLAENQVPNLPVQSISEVKILVGHSLHHVSLERCNSLTIKQFQDRLVSRGLKASCYDNPYVFRHLLCLEQPVDPLCLFKTLVESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL86</accession>
    <name>A0A6P8IL86_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC116302106</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567176.1">
        <property type="nucleotide sequence ID" value="XM_031711316.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567183.1">
        <property type="nucleotide sequence ID" value="XM_031711323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IL86"/>
    <dbReference type="GeneID" id="116302106"/>
    <dbReference type="KEGG" id="aten:116302106"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF158">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="150"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031567176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567183.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37613" checksum="7B6FB1AAB66009B5" modified="2020-12-02" version="1">MKRKKKERSSEIPSNQQPKTKKFKPQPKKPKNSVFVQPKLPKSEEEVSSNWIALQKLLSKENPAKDKAPSSLRLKHKGQKSKTTALKRKEQDEKLKNKNLDRDEDEIWFDDVDAEDIERASGRKIHNASKETVCTSKKDLAVGGFEGLTKRIAMDCEFVGVGRDGKRNMLAHVSVVNSHGCTVYDEYVAPRETVTDYRTAVSGVRSSDLKNAPDFKTVQKEVADMLKGRILIGHAIKNDLQVLFLDHPKKDIRDTAKYKPFHKIAKSQYPSLKKLSQEILHARIQEGEHSSVQDAQAAMRLYILHKRQWEKQIKDKKFKRTQEKDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM32</accession>
    <name>A0A6P8IM32_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 63-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116302680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567884.1">
        <property type="nucleotide sequence ID" value="XM_031712024.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IM32">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="116302680"/>
    <dbReference type="KEGG" id="aten:116302680"/>
    <dbReference type="InParanoid" id="A0A6P8IM32"/>
    <dbReference type="OrthoDB" id="6619788at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031567884.1"/>
        </source>
    </evidence>
    <sequence length="872" mass="99761" checksum="54BE49B604EF3F9F" modified="2020-12-02" version="1">MPEEKREETEQSNDGEGEGKEKIPSDIMPLFFTSKTQEIFGCKGDEDVTEENPFKLISKEAIEQDFKSRAAISDFHPAKKIIQEYPADEVLIVYDPSFKYDQNFYLCLTEEAKERHLNPPSAAEEGTAGEEAEEELVEQLKQFPRTPLPWDSFGSELEVNEEIVVENRQKMKFRISRIRREFGVPVSFTTRNASDTKDGIIECHSYEEETPSFLRKELDKSTQAIPELINTGNQTEWRKPCNAFTQYTPREFNEKEKEEVNKTDGLKDFVEKITPRFELALQQNEIMDVFYDDYLAMNDDETTFGAKSDSYLKEYQSFTDLQFSKEKTITHIEWHPTIKGIIAVSCGERLAFDDRIDQFSRILMTPSLVLIWSFSDPIHPLILLEAPDDIYSFKFNPSDPNIIAGGCINGQVIMWDISNYSERLKSHRQSHGQSKRNSMNSLPGFEDDSLKDQSPVIRYCAVSSIEHTHKTAVTDVQWIPDHMEIGRMGLVVENKSQHCCQLMTSAADGTVLFWDTRPTKSAAPAQTTTTNPTGIPPTFKHLDLSWKPILKVAVQRMTGNGEFGPTCFSITEKQGSRINGVKGEKEPEQTGMTRHSSSLGKSKDQGKPLENVSTKFFVGTEEGDMVYLDWKPEKDADSGKILTPRPEFVWQAHEGHINTLTRSPFFRDIILTVGGWTFAIWKEGXTSDPLLQSASHILKLTKGHWSPSRPGVFFITKTDGSVDVWDLLDRSHEPSLTQNVTASPITTIYPHQVSGKQQLLAVGDTMGTLHVMEVPWNLRHPSTNEANVMENFFEREVKRLTFVEERKRIREIEKKEHDSQLSKKQDAKKQEETEADLEARQRMEYQEYLEMEKKLLEELGIREESEELLLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMC6</accession>
    <name>A0A6P8IMC6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Alternative oxidase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302766</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567994.1">
        <property type="nucleotide sequence ID" value="XM_031712134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMC6"/>
    <dbReference type="GeneID" id="116302766"/>
    <dbReference type="KEGG" id="aten:116302766"/>
    <dbReference type="InParanoid" id="A0A6P8IMC6"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567994.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37774" checksum="358BA390414F51D3" modified="2020-12-02" version="1">MIVPKLGRFHSSGSFAGSRSVLAIILARGPRLGAVNIRSCCQMQGGYFPKISTPSAPYSVRTMYTSSYCCQNLPHFKESQNDAACKDSKKEDSPYLLPHPIWTEEDVNKVKITHKEPQDKIDKVAYYSVQLLRTAFDLASFYKIGPMTENKWLNRIIMLETVAGVPGMIGGMARHLKSLRRLSRDHGWIHTLLEEAENERMHLMTALEMKKPGALFRGVIIAAQGVFVNMFFIAYMISPRFCHRFVGYLEEEAVKTYTYCLKCIDEGKLPKWEQMKAPQIAVNYWKLGEDAMMRDVILAIRADEAHHRVVNHTLGTINPHEPNPFLPGQRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INC6</accession>
    <name>A0A6P8INC6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein ARX-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568020.1">
        <property type="nucleotide sequence ID" value="XM_031712160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INC6"/>
    <dbReference type="GeneID" id="116302791"/>
    <dbReference type="KEGG" id="aten:116302791"/>
    <dbReference type="InParanoid" id="A0A6P8INC6"/>
    <dbReference type="OrthoDB" id="1867783at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="77"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031568020.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31553" checksum="94310D4A07776744" modified="2020-12-02" version="1">MEVERTMDNSAEKRNGFSISSIMGFQKKNVEQSRTDSSNERLNEKLDNDNHSSKQTTTLKSSEKVKKVKRLSNDIDSKRYRATFDKAQIFHMERVFLINHYPDVSARSELSKATGLSESQVQIWFQNRRAKWRKQQRKRRQDIPPIFGLGYPTHLARLYPGYDPYAMFPYEYYNTDFWTCAQQQIAAIHYNGFPPPPPHTTCISSPSRSLGSSSPVSSPVSSPGSPTNLDVGSSQSQEVSPVSKSDKEALEIRNDSSLLSLRVKAKEHLAALETRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPI7</accession>
    <name>A0A6P8IPI7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116303398</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031568777.1">
        <property type="nucleotide sequence ID" value="XM_031712917.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IPI7">
        <property type="interactions" value="1272"/>
    </dbReference>
    <dbReference type="GeneID" id="116303398"/>
    <dbReference type="KEGG" id="aten:116303398"/>
    <dbReference type="InParanoid" id="A0A6P8IPI7"/>
    <dbReference type="OrthoDB" id="10070999at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06705">
        <property type="entry name" value="PDZ_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="525"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="799"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="1084"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="495"/>
            <end position="516"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="819"/>
            <end position="848"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="864"/>
            <end position="1008"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1020"/>
            <end position="1074"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1174"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="839"/>
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        </location>
    </feature>
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        <location>
            <begin position="907"/>
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        </location>
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        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
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        <location>
            <begin position="1179"/>
            <end position="1201"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="1235"/>
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        </location>
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        <location>
            <begin position="1276"/>
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        </location>
    </feature>
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        <location>
            <begin position="1313"/>
            <end position="1323"/>
        </location>
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        <location>
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        <location>
            <begin position="1352"/>
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        </location>
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        <location>
            <begin position="1398"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
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    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031568777.1"/>
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    </evidence>
    <sequence length="1417" mass="158608" checksum="CD9320377077AC28" modified="2020-12-02" version="1">MENCGERREKDNEREGSSSFIEEREALRSYLEKESLSHLDNIFPPYISLDFLKSLTEDDLEHDFRVKDAKQRLELMQAVVKLRDEDSDNDEHESDLELGLQSSAGSQSDVFVSSTLPKNFRFNRNRLSDDFGGRCRLDGLGYQASRYEETSNLVRMRANPSLGNSEPNLSGSCGDLSRRLSTCNIGGRKQTKSFIGTTSNCSKSQRAQSPLPQGSQAFFSSDSPVGSPGFPSPGLNSNHFLFSNVRKADSGGGRRWSVASLTSSGYGTHTPCSSSYSSLASSQERLHQWGQMYGDEYNLAGHFSADSDQDEEGSRSPKPRLRSRSLSPHRSIGQQEDDLQLLNNLYKERFPKAVQQMEGKLNDFVEDYTSETFGSVFGCDGVLNFVWHQVVETARDILKQSQENSLTSRYFYDLSENMDRLIIEARQKTDIDLAPIEKLMRKLLVIVSRPARLLECLEFKPGEFYNMLENESRQMDGIQEKLDITKYVKAHLGLDPEPSENIDEQDNEEVITPSNPAIPPTEDDFDYIKLISNGAYGAVYLVKHKTTETRFAMKKISKHVMLLKNQVEQVFAERDILTFAENPFVVGLWCCFETKKHLCMVMEYVEGGDCASLLKNIGALPVDLARMYFAETVLAVEYLHSYGIVHRDIKPDNLLITSLGHIKLTDFGLSKIGLMNSTTRMYEHSMDRDNQQFTDQQVFGTPDYLAPEVILTQGYGRAVDWWSMGIILYEFLVGVPPFYGDTPEELFAHTLSGDIEWPEGEEAPEEEAQDMIKRLLEQDPANRLGSVGAIDVKEHPFFDGVNWFALLRQKAEFIPQLDGEDDTSYFDTRSDRYNHSFETDNDDDDYDDIPDFYNFSTCSPRYSRIISSPIPSPPESTSPKSNHDKRSSPILQRKRSDSSPPMIRRRGHEEHDVLARHDEEPGSPRIRPRSDSGYDMEPSRHAISPLIFDSPTSPAHKTSSPESPPTPPTVRMRKKTSVTRFTPLLTTMSLDGPSEVRPSLEMPTKEHKPLDLRVALHRTQSLPPDAMRAKPSVPKLQLPGGEDNYKLKRINLESPPGSPRHDSTPPASPRKRRTSTFSMCLRPPIVIEKGPRGYGFTLQAIRVYYGDTDYFTVHHLVSGVDHGSAAFESGLRPGDLVTHVNDEPVTGLTHRQVVELILGGGNKVKLNSTELSKTTIKTGGRKRIPSAIKRVRKRPTRKARKNSVSPTNPPSTPDSMDKTPKHRPFWKRFGRRSSHSPGSGLRRSSSLKRMTSMEAKSGRPSSPKFVSPSFDFRAVSDNSSSSSLSSDPSSPSSPKALSLGRPASLHGLMPKLRTNHSPRRKSSTHVPVSPLARTPSPTSSHPPRSTSPLTIRGTSNSPQFTAITQSQRPGSPLLRRALSPELIQSMKKSETKPENRNSSSSSSDGSSTESPSSETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRD5</accession>
    <name>A0A6P8IRD5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transient-receptor-potential-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569534.1">
        <property type="nucleotide sequence ID" value="XM_031713674.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116304027"/>
    <dbReference type="InParanoid" id="A0A6P8IRD5"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="7">
        <location>
            <begin position="181"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="9">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569534.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50507" checksum="5376996D6F2BB92B" modified="2020-12-02" version="1">MASLKESWRNASQGHFNIALDEMEFTTSVLSENDRIFLDAVRRDDMTAVKELIDGGLVDVNCMDDNGLTPVQIAVKEGXLNILSFLLYRKXDIFIGNALLDAINKESLECVMVLVDYDKHQREAGTLPVKKERKMXAIKETEHYTSFLTPLTLAAQLGNYEITKFLMTQGYTIEDPHQKFCDCVECSKLGRLGCYLSHLNTYRALVSPVYISLTFLLTEENQRTKNVDPFYRALVLKKELLEHADMEYEFREDYLKLAKECEDFAALLLDQCRDLQEISSTMAMPGMKGVAGVEVRGXSSRQKKLSVLNFAIKYRSKKVYILXGLWVFGILVEEVKQARRQGKERYISQWWHLITLVIITFFLLTGALWISGYAMLAEKEDSLSLSVKFLFKQTNVTPRTLLLLSNSFYAVSLVLTFFQVSHYLQVSYLLGPLHMSMMRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRS6</accession>
    <name>A0A6P8IRS6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568953.1">
        <property type="nucleotide sequence ID" value="XM_031713093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRS6"/>
    <dbReference type="FunCoup" id="A0A6P8IRS6">
        <property type="interactions" value="1433"/>
    </dbReference>
    <dbReference type="GeneID" id="116303536"/>
    <dbReference type="KEGG" id="aten:116303536"/>
    <dbReference type="InParanoid" id="A0A6P8IRS6"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="72"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="389"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568953.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="65791" checksum="9B3DC8F9E39BA393" modified="2020-12-02" version="1">MNPHGNSLKSDQLSSIVMSFLKKRKFTDGEDSTGKHQARGTKHKVEDVALKTSVKSECGIPNVLSFSVNHLDANNYDEQYGSLKSFITGANPAYRQELVKLLFPVFAHSYLDLIAKGFLNNAQNFFSKYSSDLMADFKEDIQNLQAITDSERLKSSDTAANFRRSKYLIKLSHKVFTYLMQYLRSSEHLLLLQLINRNLAIEISQSKPGKNIGSNGNEEEKDTGVNQKVSKETKHSKTVVEKDDASLKALKESIDKIRNGPACLPSICFYTFQNAYQGLSSVGICNDGSLLSGGFEDSSVHLWSLIPKKLIKPKTKTCDISKIMLASDTAVANGGKVETVLGEDFPLLGHCGPVYATCFTPDNTALLSASEDTTVRLWNLHSYSNAVIYKGHNYPVWCLDTSPQSYYFASGSHDCTARLWNIEYNYPLRIFAGHLQDVDSVKFHPNCSYIATGSTDRTCRLWDIQAGNCVRLFRGHKGSILTLGISPDGQYLISSGEDRRIRVWDLTAGNLLKELRGHTDSVHSVCFSSDGTLLVTGGMDCHVRVWDFHQVSKCASSAASAQSSSELLASFSTKNASVHSVRFSSGNLVLAAGTNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT32</accession>
    <name>A0A6P8IT32_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTPase Obg-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570356.1">
        <property type="nucleotide sequence ID" value="XM_031714496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT32"/>
    <dbReference type="FunCoup" id="A0A6P8IT32">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="GeneID" id="116304722"/>
    <dbReference type="KEGG" id="aten:116304722"/>
    <dbReference type="InParanoid" id="A0A6P8IT32"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008956">
        <property type="entry name" value="PRK12299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
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    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="178"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570356.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37886" checksum="C894CEEDE2340DA2" modified="2020-12-02" version="1">MKLYHRTLTYSVWRHYCSTQKDRQFIDWKKIVIKAGNGGDGSAHFRRKKCQPRAGPDGGDGGHGGSVLLVADASYKELAHVQKHNKAGDGEGGKQNDCHGRTASNLFIKVPLGTVATHYKTVIADMCTEGQHTVIAHGGRGGLGNAHFKSATNQSPEIATPGTLGEEKVIELELKTIADVGLVGFPNAGKSTLLRAISKAKPAVAAYPFTTLNPYVGMIEYDDYHQIAVADIPGLISGAHLNKGLGHSFLRHIERCRCLLYVLDISQNDPLKQFSSLQQELELYKEGLSRRPAAVVANKIDTVENFKSKNLVEELDLPVIPVSALFGQGIGVLKTKIRLLFQTSLNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITQ7</accession>
    <name>A0A6P8ITQ7_ACTTE</name>
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        <submittedName>
            <fullName evidence="3">RNA-binding protein 25-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569605.1">
        <property type="nucleotide sequence ID" value="XM_031713745.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="116304090"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569605.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="34229" checksum="B0C9CE17F067A7B8" modified="2020-12-02" version="1">MPSGKGRSKEDTWKESDLKKAIQGDKKERPSRREDDRRERKSDRDDDRKRRECREDLVNGEDKDRDKRRKERSSDKEKRRDKDRDGEKTRERSDRDKERRREKEGETSGRGRERKEGERSEKDKVSSRDRERLRERDRREREHGESEGRRRDRESDKDRERRHRSRRDHEGDDRRDERKLKEKEDETGSEERRKDRERRRRRDEGESSRHRDENRDQKREKSRERDHRDRRKEREHDESRKHRDKSGERREKKRERDDRERRKEKEEVWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITY0</accession>
    <name>A0A6P8ITY0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570494.1">
        <property type="nucleotide sequence ID" value="XM_031714634.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570494.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52246" checksum="5D83C8D0251D49EB" modified="2020-12-02" version="1">MEDLGPVPEPPTQTWAEMVTMRMDESLKENVAPDFDRLTELLPDWDHTKAQLEFDDSNQWGKEIIIGRLSKAGSKIYVIRDERGRYFADPKIPPTLRKAIGEPNLIVQQGLSQEETKAAVSRFLNKAVTKLPAVAGGQMETVADLRTQLGRQNELLQAKNEEIARLNSTQREMNAKMCKMQSEPNPAILAEQTIRRVKLREMTDEIAEIARQKKAAENTLNRITAERDDLLKANADEAALRAAFQELEAENQDLKGRIGELEGEYADQNEATAKSHAAQVADFRQRLSNLLSKKTTAENDFRSAISHLAGKDAELTRMGEEVVESHARERRIMAQMAEKDLQIGQLQETIEDLRGQIGRQQELVADQTRSEEERKAAQKEVETLEVRVAELRTQRKGLERELGLTTKEKIKKLLVKYGIPLAFAVAISSVVGVILSALKSTGAGVKKLGSGLTDLGKKDSSLSSWAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVI8</accession>
    <name>A0A6P8IVI8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116304523</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031570130.1">
        <property type="nucleotide sequence ID" value="XM_031714270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVI8"/>
    <dbReference type="FunCoup" id="A0A6P8IVI8">
        <property type="interactions" value="4176"/>
    </dbReference>
    <dbReference type="GeneID" id="116304523"/>
    <dbReference type="KEGG" id="aten:116304523"/>
    <dbReference type="InParanoid" id="A0A6P8IVI8"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000004">
        <property type="entry name" value="Poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="214"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="423"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="593"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="659"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031570130.1"/>
        </source>
    </evidence>
    <sequence length="731" mass="82918" checksum="0112C2B8B7DE2C30" modified="2020-12-02" version="1">MSNSTNVSNQPQRTYGVTSAISHAKPKPVDIELSKKLEETLKPYGVFESEDELQHRMVVLGKLNEIVKQWIVDVSLQKSMPENVAHSVGGKIFTFGSFRLGVHTKGADIDTLLVAPRHIDRADFFSSFYDLLKNHEDVKELRAVENAFVPVIKLTFCNIEVDLLFARLALPEIPDNLDLLDENLLKNLDPKCVRSLNGCRVTDEILRQVPNIENFRLTLRAVKLWAKKRGIYSNVLGFLGGVSWAMLVARTCQLYPNAVASTLLLKFFLVFSRWEWPNPVLLKQIPLPHENRLGFQVWDPRLNTSDRYHLMPIITPAYPQQNSTFNVSMSTRQIMQEEFFIGFKNSEDVQNGKANWDILFVPFNFFSRYKHYIVLSAFAASQDNLLEWIGLVESKVRTLVLSLENNAYITLAHVNSTSYGPLESEKDKFVTRWFIGLLFKKTENVNIDLTSEIQMFTNTVHNQAISTKLIKDGMTIEAKHVRRKQLNKYLPPGVFKMKKKSGVVGDDKPNVVKNENILNESSSLEISTESIPEGKEELPNVKDIIDEKMLTDDHEHKASINNDAQISKPSIIKESQGEVISLAPITCNTQEITSTAAPAKVQPDEKRQGVKRPSTPLGPDTKRTKIENPTETSPQEFIIKEDPSNINTTNLVKSVDEIEALTSPTDDEMTSSNLKPSRGIKRRSSDQKDISTKQLKKDSFQEEEEKELYDTEELQPQLPLPVKNSIKLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVJ2</accession>
    <name>A0A6P8IVJ2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein unc-104</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC116305513</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16 17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571306.1">
        <property type="nucleotide sequence ID" value="XM_031715446.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571308.1">
        <property type="nucleotide sequence ID" value="XM_031715448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305513"/>
    <dbReference type="KEGG" id="aten:116305513"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000001">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000004">
        <property type="entry name" value="Kinesin-like protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="3"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1442"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="622"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031571306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031571308.1"/>
        </source>
    </evidence>
    <sequence length="1556" mass="176654" checksum="C68D0061D36BA9FE" modified="2020-12-02" version="1">MSSVKVCVRVRPFNARENLRQCKCIIAMHGPTTSILNPKHLSEKPKNFSYDYSYWSHSQDDPHFANQKQVYSDVGCEMLQHAFEGYNVCIFAYGQTGSGKSYTMMGKQEPGQKGIIPQLCEELFQKVEQETSEDLTFSVEVSYLEIYCERVRDLLSPTAKNNLRVREHPVLGPYVEDLAKLAVTSFADINDLIDEGNKARTVAATNMNETSSRSHAIFSIIFTQRKHDELSNLTTEKVSKLSLVDLAGSERADSTGNTGERLKEGANINKSLTTLGKVISALAEQSSHHKKKRHSEFIPYRDSILTWLLKENLGGNSKTTMIAAISPADINFEETLSTLRYADRTKHILCKAVINEDPNAKIIRELKEEVLKLKEILLQEGYDVEHLESMLAKSGPIRRTSGEYGTIEKLQVSEKLIAELNETWEEKLRKTEAIKQEREAMLVEMGVAIGEDGNTVGLFQPKKSPHLVNLNEDPLMSECLLYYIKDGITRVGSAQAQSHQDVQLSGTHILDEHCIFENTNNVVKISPCENSRTFVNGKLISEITTLKSGDRIILGNNHVFRFNHPHQALAERIRRSRDNVDQETRRSRDNVDQETAAREANSEEPMDWSYAVLELLREQGYMKEMNDRVIELEDRIRYEKDQAGLLLEKQRKTYETKLQQLQRQVDLTSFPSSDFESEIDLTSAGSESPLTEREMNLALSVIYKWRTFFYTSLRDDILSHAVLIKEANAISVELKKKVDFQFTLLTETLFTPLPENLREDSHQDNHPTVVCVEVQDKKNGATHYWSLKKLRSRLEDMRFMYETAAESTASVTFESGDPFYDDFPWFRIVGRSFVYLSNLVYGISLEQSTPIISETGELKGHLLISIQQCQDQRTEMDEASRSCISWLTFGESVTRWKNPDLDEIEEDEGGERFSKGALVMGTTFIFTVTVIKAAGLPVDYTDIFCQFRFLDSAEDVGFSTEPASIMGGDSALEFNHYQKIGVLVTREFIDYVSTRPLQIQVFGHYRNHPNHQASITMPRAVPKVTDDVRPVEQVYIQPTSSTTKDEEPTSLTFDFVVWIEVFELSPSGEYFPCVVKPKKDETKVFLLHQGIQRRLVVTLMHENSPDVRIRKLTSVTIGQVRSSKAAPSRLSSPLSLNILSPQIQSHPNDERAVFKFEASWDSSLHNSILLNRVTPLGEVVYVTMSAYLELDSCCRRACLSKDICLEVYNRDAKTTPSRSVWKIITGSTANPPCFKYSGIYELTLHPADRSGRVRRPTRKVVDTSNIYVRGEENLHGWKPKGPSIIDEHQKQLDKLERLQEVGKARHILAVADHLREPQCPAAKLPPCNTALFSSTTSSSFPTQTSRTVNFGSLSLSSSYLSGCSLSVGKSPAFTNQVDSEKTQECLLRKCLHLLTSKKAIKDFQQMVQSSAPQSSRDPTSPDDVSRADYFVPSLKEIRKNPVIAKKGYLLVMDDSSCLWKRVWVVVRKPYVLFYSHEQEPIEYFVINLKNAKVECSQDETVQTTNKVFSLRTGHGRYLLQPTPDLEEEVHEWLYAIDPLLMGTIRSRRSSMRRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW28</accession>
    <name>A0A6P8IW28_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">transketolase</fullName>
            <ecNumber evidence="8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116305455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031571217.1">
        <property type="nucleotide sequence ID" value="XM_031715357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW28"/>
    <dbReference type="FunCoup" id="A0A6P8IW28">
        <property type="interactions" value="1532"/>
    </dbReference>
    <dbReference type="GeneID" id="116305455"/>
    <dbReference type="KEGG" id="aten:116305455"/>
    <dbReference type="InParanoid" id="A0A6P8IW28"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000033">
        <property type="entry name" value="Transketolase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004559">
        <property type="entry name" value="PRK05899.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF1">
        <property type="entry name" value="FI06132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="14">
        <location>
            <begin position="319"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031571217.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="68543" checksum="21CA38F25BD4EA83" modified="2020-12-02" version="1">MTEYHRPDQKKVQALKDIANKLRINSIKSTNAANSGHPTSCASMAEIMSVLFFNTMKYKATDPADPSNDRFVLSKGHAAPVLYAAWAEAGLFPEERLMTLRKIDSELEGHPVPERQSFVDVATGSLGQGLSCACGMAYTAKHFDKSSYRVFCVLGDGESAEGSVWEAMHFASYYKLDNLVAVFDVNRLGQSQPTSLEHDMETYRKRAEAFGWNTIVADGHDIEALCRAFYEAEISKDRPTCILAKTYKGRGFPDVEDKENFHGKPLGSKGVEIIAHLEKQINSFKHDLRPGAVEATVPEIKDEPVKLSQPPNYKIGDKVATRNAYGTGLAKIGETCDRVVALDCDVKNSTFSQTFKKAFPDRFIECFIAEQNMVGVGVGCATRARTIPFVSTFACFLSRGYDQIRMAGISHSSVNFCGSHVGCSIGEDGASQMALEDLSMFRSIPHCVVFYPSDAVACERSVELAANYKYMTFIRSSRPATHVIYNNDETFEIGKAKVVHQNEKDKVLVVGGGVTLHEALSAAEQLAKENIHIRVMDLFTVKPIDKEGLIEHGRAVGGRIVTVEDHYYEGGIGEAICSAVAELGEFKVHRMAVPRVPQSGPSTALLEMYGISASSIVKKVKAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYG5</accession>
    <name>A0A6P8IYG5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox protein aristaless-like 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116306594</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Binds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572541.1">
        <property type="nucleotide sequence ID" value="XM_031716681.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IYG5">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="GeneID" id="116306594"/>
    <dbReference type="KEGG" id="aten:116306594"/>
    <dbReference type="InParanoid" id="A0A6P8IYG5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000127">
        <property type="entry name" value="homeobox protein aristaless-like 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 13 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="10 13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="17">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="13">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="221"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031572541.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38944" checksum="74CD2B96CBCD8DC3" modified="2020-12-02" version="1">MEKFPDFMPSMDQARKQPPYPSASNISHCQQMVPRSREINLNVQVHHEGGSVPLQHLPAHPGDMEEKYNQNVSPSSXLSHGSPSCGEMDSSNSESPQKRKKRRNRTTFTAYQLEEMERVFQKTHYPDVYTREQLALRCDLTEARVQVWFQNRRAKWRKRERYSQVPVPVRGMPTSPYDQIPPPSWPRNDPSVGISQGGPMPRHLPSHVTLPSYGAVLHAQSMSSMAGRTSPPGSPNHVINTSMAPSSHIRSHAHQQGPHPNVTITSSSMPHNHISSSNYPPHSSPGACHSPPSAGPHVSRDCRIENEQDLQGGQCVVRHSSSIAALRLKAKEHAVAMGMVRVYNMRADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYX6</accession>
    <name>A0A6P8IYX6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116306444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572374.1">
        <property type="nucleotide sequence ID" value="XM_031716514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYX6"/>
    <dbReference type="FunCoup" id="A0A6P8IYX6">
        <property type="interactions" value="3339"/>
    </dbReference>
    <dbReference type="GeneID" id="116306444"/>
    <dbReference type="KEGG" id="aten:116306444"/>
    <dbReference type="InParanoid" id="A0A6P8IYX6"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031748">
        <property type="term" value="F:D1 dopamine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099639">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031572374.1"/>
        </source>
    </evidence>
    <sequence length="798" mass="91273" checksum="253D5C914E2C867E" modified="2020-12-02" version="1">MPPTQPPSTEDQEKLLDEAIQVVKSQSFQMKRCLDKGKLMDGLKHASNMLSELRTSLLSPKSYYELYMAISDELRHLELHLVDEFQKGRKVSDLYELVQYAGNIVPRLYLLITVGVVYVKAKEASRKDILKDLVEMCRGVQHPLRGLFLRNYLLQSTKNMLPDVGDEDERETPEGTGTIKDSINFVLLNFSEMNKLWVRIQHQGHSREKQKRERERQELRILVGTNLVRLSQLEGVTAEMYKKLVLPGIIEQTVNCKDPIAQEYLMECIIQVFPDEYHLQTLTAFLSSCAELHPQVNIKNIIISLIDRLALFANRSDGGIPAEIKLFEVMSEQVSSVMQVRSDMPTEDKVSLQVSLINLALKCYPDRVDYVDKVLQYTSELFSKLEIGSIDKNNPVSKELTKLLKNPIDAYNNVLKLLELKYFIPMFNYFDFATRKEMSLYVVSNAVESEVEIPTQEQIDTLLTLVSVLVTDQDDQPSEPDDPEDFAEEQNLMGKFITLMKANSPDQQYLILTTARKHFGSGGEKRIKYTLPPIVFSAYQLAFQYYDAKDEDDKWDKKCQKIFQFCHQTICALAKAEYAELPLRLFLQGAMAAGRVGFSNSETVAYEFISQAFSIYEDEISDSKAQLAAITLIICTFEQMSCFGEENHEPLRTQCALAASKLLKKPDQCRAVGVCSHLFWSGKSKDIEDGECRDGKRVMECLKKAVRIANQCMDSTVQVQLFIEILNRYLYYYEKNADAVTPTILNQLLDKIREDLPGLEENEETDQITKHFKNTISHIELKKRSTEESSPSFEGVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1C1</accession>
    <name>A0A6P8J1C1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="4">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031573284.1">
        <property type="nucleotide sequence ID" value="XM_031717424.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307259"/>
    <dbReference type="KEGG" id="aten:116307259"/>
    <dbReference type="InParanoid" id="A0A6P8J1C1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF209">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="523"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="639"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573284.1"/>
        </source>
    </evidence>
    <sequence length="816" mass="93914" checksum="21B32EB6A20CA2CF" modified="2020-12-02" version="1">MASKATMSAKDIKPMPQECWRMMRKGCNMQKIWIGMKTKVKAPRKPQEKKTNLTKDQKQVVFTLKRKEKRVNIPDITKVITCESDPEKFQLVKNYFSVEACFCVITSTSEEIFFAAPNIDEANLWVNGLQRLIENATTKNRGEERRVLWLSKAFSRLTKEGNDFVKYADLLNFLTSQGMNVDPLFVKKSLKKFMMEKKKTGDQITQEDFVQFLGQFMMRKEFFNLFLQTSSDGSFLTVEDLEYFLTKRQGECSVSRDNCRQLITSYEVTQEGRESGEMGIDGFIKYMSSKDGELFNPDHEKVYQDMTQPIAHYFIASSHNTYLSGDQLQGDSSVDEYVKVLKGGCRCVELDCWDGDNGEPVVYHGHTLTSKILFKDVIEAVKKHAFEVSPYPVVLNMENHCSVEYQKKMARHLIEILDDLLYKDPXDKNLTGSPSPETFKYKIFVRSKKLKQEAEESNEEFAMDDDDDDDEDDEEEEEKDEEKEKEKARPKTATNQNVQNNQAEVTTDVKKKKKPPKPIAKEFSLLINYFINTHFVSFDHSTTHGQYYQSSSFSENKLSKFLDREPDVFVEHNKKQLSRIYPAGFRVGSGNYDPQEAWNVGCQIVALNHQNCSKAVQLHHGRFRQNGKCGYVLKPEFLRNPDIKFNPFDLRNLGHMARKLKVTIIGGYRLSPPNSKEPDRIKDYLDPYVVVNIHGVPADKFYFRTKTIKDNSYDPRWDEGFSKKIHVPELALVRFVVYDDDFGKDDFIGQSTVPFTSIRPGYRQIILLDKNSQPYTSGSLFVHVTITESDIVQTSADSAETTAYEGSRKGRGCTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2W9</accession>
    <name>A0A6P8J2W9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Proline-rich transmembrane protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC116308085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574306.1">
        <property type="nucleotide sequence ID" value="XM_031718446.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574307.1">
        <property type="nucleotide sequence ID" value="XM_031718447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2W9"/>
    <dbReference type="GeneID" id="116308085"/>
    <dbReference type="KEGG" id="aten:116308085"/>
    <dbReference type="OrthoDB" id="10066605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="9">
        <location>
            <begin position="33"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
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            <dbReference type="Pfam" id="PF25987"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574306.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574307.1"/>
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    </evidence>
    <sequence length="375" mass="42683" checksum="33EE221DC9CF0E9A" modified="2020-12-02" version="1">MSGTPSSSPEYIPFSSAEPERSPTSEPEASLPNSAAEPIPEWDTATVTWEWFWDVHWIGLGCLFTILALYSLWSVLNVARESKKRSRVVSIFICSMIFVLGSSRALFLFINPYESPQCHMLSVCPFILTRILFGLGLPCLTAAFSFIQLVFLQVVKLKLYPRKVQNWKFLLTIVMIHFSLALVIEIVVFLYADWRSLSLVCQAFFIVFSLVLSTSFIYTGRKIIHRVNQSARQVSKMGTRSVNAKNIAKNPSRKPGLSKLVRITFLTAALGFISCALQLYSIFVVYDMYRSTSKREPEPWPWLVFQTLYRIVELLAGITMGYVCPRQANVQKKSPMSPCWSTFEGRKRRYRPAVFYTDSGTTDPSVNHSTELELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3N7</accession>
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        <submittedName>
            <fullName evidence="5">Polycomb protein Scm-like</fullName>
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        <name evidence="5" type="primary">LOC116308010</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="5">Tentacle</tissue>
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        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
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    </dbReference>
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        <location>
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            <end position="104"/>
        </location>
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            <begin position="103"/>
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    <sequence length="434" mass="48204" checksum="761D479F74C535A1" modified="2020-12-02" version="1">MATVAKEEEKQLQQHSDKITIQRDRSGHYGLHISNISAEINEMDLRSLFESSGFVKICKIIKTYDNDRVAFVKFLDQEEAVRALNKLNGTKLGGSIITVRPAYESQKSRGNRYYKERTNSSESLSKSRDRKGHQNHSGNERTSPKDEKTVNEQKHLRKDENCDVFYTSQDVRHTNNTSDMSSAPTSSSGKNGVQNIPGTKSIENTSTQLVYSIATGSSGENYVQSAVRSRSSDLAQSNGTPQSYSQRPNTAQRFAGPQGNHPVTSSNSSQMFSTGRPSPSRGCSYQNSSITSPRLVATANNDAQNGYNYPGGVNNNYYHSLSNKTQTGNPYTMHNGTPSSQFSPTCEISKPMRDLSLSNPGSMYGPSNVSKWSVKDVINHFNIQEECSKSMVDFLEEQEIDGNALMLLEQDSLLHFMKLGPALKLLNLRDKLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3P6</accession>
    <name>A0A6P8J3P6_ACTTE</name>
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        <submittedName>
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        <name evidence="7" type="primary">LOC116308370</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
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            </authorList>
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    <dbReference type="FunCoup" id="A0A6P8J3P6">
        <property type="interactions" value="239"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF147">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL7"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
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            <begin position="562"/>
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            <begin position="456"/>
            <end position="490"/>
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            <begin position="64"/>
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            <begin position="575"/>
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    </feature>
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            <begin position="595"/>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_031574636.1"/>
        </source>
    </evidence>
    <sequence length="866" mass="99151" checksum="FFE916AF3AC3D530" modified="2020-12-02" version="1">MPCSPRSSVLSRNSSSMASSSVRLSTDYLDVKRELTADISARNSDCESVNNEGEEEEDVQTETHSNTRSSRIKTQTAKKKKVRSRKVTANIAGTKYDVVRKACLQAGMCITRDDDPNCFFYWSDSAIPGERVTELKSYQRINHFPGMGEICRKDSLARNIAKMQRAHPDEYSFTPQTWVIPAEYAAFQFYCRDLKKKKKVKTFIVKPANGAMGNGISLIRNGDRVPSHEQIVIQEYLDRVSKKDRMRITAAFNSSIESIYNYRFFLITLNVRLGTEPYQSPSDENLDELFMHLTNYSINKXNDNFNKDDSTDNGSKRSIKFLKEWLQSMDYDVNSMWRNITDVIVKTLIVAQPHVLHSYRMCRPGAVPGSDSCCFELLGFDIMLDRKLRPWVIEVNRSPSFGTDAKLDAEIKGGALRDTLRLLNIKSSDRRRGMAAEKAESQKRLLTQPKRSEYGLSELEKKKMILNKRRLELKEQLNKIRREAAKEEYENMNMGNFKRVFPPDDRARNEKYNGLLADAFKLFLSGRASTLQRDNNQPFSTLREEEILDLLEQCEADETLSQFDKTGYRPYSKGPKPLSSMPSAKSPSSKEDMCSNPTLISQRQSSFETSSAHRSTDLSSSFSLPRSTSQRIVTSTSSPPMKFNPVVDAAYLNAAVREREDELCRRTLQAFADMRIKFPGKTDEEAEMILENIQENWKFHKPRVASYWLVKLDSIKRRKVIDIVKTNTRAILQRIWRSSDVDNLRLCRIFSRVFNRLLWSHGQGLWNCFSSIGNSWETIFSKSTEVLSPTEMSCCRRIVELCRDCLLIVYQFASDAKAAGAVTNGVTQNETTTREPLRRVPDLTSQQTLSARMARLSKTSQVQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4A8</accession>
    <name>A0A6P8J4A8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tripartite motif-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116308218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574459.1">
        <property type="nucleotide sequence ID" value="XM_031718599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4A8"/>
    <dbReference type="FunCoup" id="A0A6P8J4A8">
        <property type="interactions" value="3765"/>
    </dbReference>
    <dbReference type="GeneID" id="116308218"/>
    <dbReference type="KEGG" id="aten:116308218"/>
    <dbReference type="InParanoid" id="A0A6P8J4A8"/>
    <dbReference type="OrthoDB" id="5959490at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="120"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574459.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45035" checksum="F2157C445E25DD6C" modified="2020-12-02" version="1">MAGHLNPFITKLKKDLTCTICKRFFNGPTTLSCLHSFCSKCLIDWNKTCKEGRQRFSCPICKKPIDGSGIDMSKPRISFYLESLITLVSSIEGKSKQGSQPPECKCCALDHKSHNKVSILEETKSIKQTLRQDMKELNKVVEKYNQEKEKIRESMATIQSHFESAKKSVRGVAETAFKLIMDHENEMIKVLNEKERMQKSECLRLQGKINSELQNVSEIQLQYQCLLENDVSLEIIEKQNFLQKKCNTILDKEAMLQKKPMLKRGNVTVDYVTNPEVMQSLQNIGKLVETKPLDPSRCTIEALKEVRNGYFNELEFEIVTRDCDGEVCCVTGNFEIRIIDQEGDEIEKNAAISEEKGKYRAVVTYRAEKKSPCEIQVNIGGKRIKNSPQIVNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5L8</accession>
    <name>A0A6P8J5L8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116309035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116309035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575426.1">
        <property type="nucleotide sequence ID" value="XM_031719566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5L8"/>
    <dbReference type="GeneID" id="116309035"/>
    <dbReference type="KEGG" id="aten:116309035"/>
    <dbReference type="InParanoid" id="A0A6P8J5L8"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031575426.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26303" checksum="91078B24DE7D6984" modified="2020-12-02" version="1">MCTLLNNKALLDLLQVIRQQLLTNISKCLTAYLFGVSLLLGSSALASLTHNSSKQDTIFHGTPVQPSFNCLTTEASCVFSREGIEVASPGLDLVFRPITQRRKRVPGSFLQRQGFQNMASSREQKMDAREVNQSPSENHTFPRSIDISVLFKTLGNFTSQNLNLKTRLVTHGRYSNGTDRELSVQSWSSLCVHKMNVGLFGPQIVKKRCFEKFPKSSVSSTEWNCYYRQQLCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5Q7</accession>
    <name>A0A6P8J5Q7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116308712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116308712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575052.1">
        <property type="nucleotide sequence ID" value="XM_031719192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5Q7"/>
    <dbReference type="GeneID" id="116308712"/>
    <dbReference type="KEGG" id="aten:116308712"/>
    <dbReference type="InParanoid" id="A0A6P8J5Q7"/>
    <dbReference type="OrthoDB" id="10417252at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031575052.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13477" checksum="1BA89B2145410254" modified="2020-12-02" version="1">MTVTVKVKCEERDIKQCYMDKINTLTKQLHPAIEEDSAHDINYVVKTLNRRWQDTSDKLDQCRDLGRPLFHEDCWLVAYIKNSLTTDKRPQEVHFKYTVLIMADKCTRTRSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5S2</accession>
    <name>A0A6P8J5S2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116306802</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572760.1">
        <property type="nucleotide sequence ID" value="XM_031716900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5S2"/>
    <dbReference type="FunCoup" id="A0A6P8J5S2">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="GeneID" id="116306802"/>
    <dbReference type="KEGG" id="aten:116306802"/>
    <dbReference type="InParanoid" id="A0A6P8J5S2"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031572760.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48759" checksum="7847A6D00A28E229" modified="2020-12-02" version="1">MARVRYMTDNEKSVLVNNFEKRGWIPCADDEDWNFYWASVQTVRAIFNVETGYRLADDQVINHFPNHYELTRKDLMLKNIKRYRKEVEKEGVPLAEKDESGRYLYLDIIPVTFLLPADYNLFVEEFRKNPSSTWIMKPTNKSQGKGIFIINRLSQLKKWSKDSKGTPLMHATGKDAYMISRYIDNPLLIGGKKFDLRIYVTVTSYRPLKAYVYRHGFCRFCTVQYNASLNELDNVFIHLTNVAIQKHGEDYNSQHGGKWTVKNLRLYLEGTRGKELTDKLFDDINWLMVHSLKAVQNVIANDRHCFECYGYDIIIDDNLKPWLIEVNASPSLTSTTSADRIMKYNLIHDTMNIVVPNGEIPDVRWNKIPSKEAMGSYDVLYDEELAQQDVVERDLKSRTSQGSTSRGSKDGKTRHTTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J601</accession>
    <name>A0A6P8J601_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116308805</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116308805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575157.1">
        <property type="nucleotide sequence ID" value="XM_031719297.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575158.1">
        <property type="nucleotide sequence ID" value="XM_031719298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308805"/>
    <dbReference type="KEGG" id="aten:116308805"/>
    <dbReference type="OrthoDB" id="5974354at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653289" evidence="1">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575158.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24026" checksum="B4FF31FB47900C5D" modified="2020-12-02" version="1">MKQKIILLLQLLVLVATATLEEEIAGQEESELALRQIEPSDCQFQVIKSCNHQFKSLFEKSAGEPDLEVYCNGMQSFMTCLETSSCSGPFLDDYXYVVLQHGMMDKKLNLCPDHVYTTLRTKVQATTKHRAIDIGADSSAECSVLVHKKCVLIFTKNMETNSNMCQDVQSFLDCYKKESPTCKAEITQDFAQLCNQLGEEMLKASEKHRGMMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J841</accession>
    <name>A0A6P8J841_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CD151 antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116307219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573235.1">
        <property type="nucleotide sequence ID" value="XM_031717375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J841"/>
    <dbReference type="GeneID" id="116307219"/>
    <dbReference type="KEGG" id="aten:116307219"/>
    <dbReference type="InParanoid" id="A0A6P8J841"/>
    <dbReference type="OrthoDB" id="9993879at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF534">
        <property type="entry name" value="TETRASPANIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031573235.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="34560" checksum="526F3F24DE6C009D" modified="2020-12-02" version="1">MAWDGRKVVKSSVIGFTVLCFLIGLVLIIFGDTIATPFGDYFTLKAEAFNDNLGLRIGLIFLILIIAGICIFAAVKENNRLLTVMAVLFFIMFVTELALGIVYFTMRNEGVLKETKSASGHQLLSMYGTDPGVTKALDDIQRGFGCCGVMDYRDWFTSGWVAKQGVSNRVPSSCCKVPSPTCGWDMDIKNPVDVINIVGCTGLNYFHDKNQRIVGGAGLGVAFIHLATILCCFVFSCCFNSVGGLSPVDALKGKDPEYSDEVTGDGSGSGKSMSGSGSPSKRQSNRKKSMPAFQEPFDDDDDLPENSSQDLLDKSKTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J8E5</accession>
    <name>A0A6P8J8E5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116307276 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116307276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573300.1">
        <property type="nucleotide sequence ID" value="XM_031717440.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116307276"/>
    <dbReference type="InParanoid" id="A0A6P8J8E5"/>
    <dbReference type="OrthoDB" id="757982at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="139"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="7">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031573300.1"/>
        </source>
    </evidence>
    <sequence length="813" mass="90085" checksum="EAACBE6BAA890B37" modified="2020-12-02" version="1">MADSYSRFAVLDENEIQNLKEKXKNENTQKSTQTWLKVWRSWAEERNVNXNLEENPPVILDEILQRFYAEVRNKNGDHYEPESLKVMMASLDRHLRDQGYPFSITKDREFHQSKQVLEGRAKLLRKERKDKRPVSKAGSILEEDELWENEKLGSGSPRTLCQTMWWILTQHFGLRGREVHYSMXVEDLKLCRDDRGVEYFTLSENPTKTRQGGLNTKRRLGQPKMFATGGARCPVGLLKEYLCRRPPELLESGPFYLAIIDRPTTDVWYKKQRLGVNSINQMMKTVIESTSVSATGKRLTNYSAWKSMQKGKAVKTEAQSPQKLQVRVVAPPIPRQQTAQVQKKYIIHQANGQQVVLTPVSSQPAQNALTQVATNVKMTPVVSPVNQTVKAIAAPTNTQNAQQPGLRVVKVVTHGSPVLANTKPVLVTASAATQGAPMKVEPLVVPKVGGPTVTKVEESHVPKVGGPPVMLKVNSHAAAKHVANLPTMVPVTAIVVDPSPKVVSVQSLAAPEQNYSLSDVVQQAKPIEAKPQSDYKPLESLIEVNRHAAESSISPVSAVIPDNXTSSSSMTSPTLGRKDVTVNDRFRYIAPSGKTPISSHSTTNTPGPQGETLPQVKLETPTPLDVAETGQVKTEXQQSTPSPVSKLKRPHDDDAEADETPRKRNADSAVIVIDPPSPPKDTYTDNNPDGTDIAVSKTEANTSTIKVDTNDMDDGNSQKQKTLANVDKNIIPIIDISIVEAVKKMSPQQQFKALLSRTQQLYELRGNVCKLLRVLVPELEVDDRKENFEDQTVDELLQQVLEQAETSESESNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JDU1</accession>
    <name>A0A6P8JDU1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116308360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116308360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the avidin/streptavidin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574625.1">
        <property type="nucleotide sequence ID" value="XM_031718765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308360"/>
    <dbReference type="KEGG" id="aten:116308360"/>
    <dbReference type="InParanoid" id="A0A6P8JDU1"/>
    <dbReference type="OrthoDB" id="2821340at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.30">
        <property type="entry name" value="Avidin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005469">
        <property type="entry name" value="Avidin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036896">
        <property type="entry name" value="Avidin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005468">
        <property type="entry name" value="Avidin/str"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051764">
        <property type="entry name" value="Avidin/Streptavidin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34399:SF6">
        <property type="entry name" value="AVIDIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34399">
        <property type="entry name" value="AVIDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01382">
        <property type="entry name" value="Avidin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00709">
        <property type="entry name" value="AVIDIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50876">
        <property type="entry name" value="Avidin/streptavidin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51326">
        <property type="entry name" value="AVIDIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031574625.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="43391" checksum="69AB4F45755D9C12" modified="2020-12-02" version="1">MLAGLPVYFITHDKSSVTYTSFAYCANSAEGDTCCAVSVAKRMFSIFIILAILSTALTDKCNNLDGFWYNQLGSEIFLKHSNDGKLIGEYRTAVERSEGSAGSKTHSILLGAAPYNKPGTTFAFAVVWNNGSSTTSWTAQCVVCEDGHEKFLTSWLLRSQVDICIDKWKSTRIGRDTFTRYEQLSGPRKPNKNPPSLPAIDTNSHAIIFKPRQPCDIVGTWYNSVGSEMIIKQDFNGVIVGEYRTAVEREKGAAGSTHSMIFGIGTRGDMNSTFAFFVVWNDGASVTGWVGQCHICGINKTEVIESTWLLRSKIGRCGENWKSTLYGENSFTREEQKEGXRKHLGIDTPERDGEPSNPRGASTIVRACYICWWLGMWLIMLCSQSLSNECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JEJ3</accession>
    <name>A0A6P8JEJ3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116308517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574820.1">
        <property type="nucleotide sequence ID" value="XM_031718960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JEJ3"/>
    <dbReference type="FunCoup" id="A0A6P8JEJ3">
        <property type="interactions" value="2305"/>
    </dbReference>
    <dbReference type="GeneID" id="116308517"/>
    <dbReference type="KEGG" id="aten:116308517"/>
    <dbReference type="InParanoid" id="A0A6P8JEJ3"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574820.1"/>
        </source>
    </evidence>
    <sequence length="841" mass="96253" checksum="5BADAA9B73C03E56" modified="2020-12-02" version="1">MSSLFRSEEMTLAQLFLQSEATYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCEELERKLRFLQKEIEKADIVMVDSGENPEAPHPREMIDLEAQLEQLENEMKDSNANYEALMRSFLELTELKHILKKTQTFFEEAEHHVHQQQIHDPNKADDTAFLLGEEARAAPATQLGFVTGVIARERIPSFERLLWRACRGNVFFKQTEIEDYLEDPSTGDQVNKSVFIIFFQGEQLKSRVRKICEGFRANLYPCPETAAERREVAIGVETRIEDLQNVLSQTKDHRHRLLVTVSNNVNQWFIKVKKIKAIYHTMNMFNLDVTQKCLIAECWCPVADLDQIQAALRRGTERSGASVPSILNRMNTQQDPPTFNRTDKFTQGFQVIVDSYGVANYQEVNPALFTVITFPFLFAVMFGDCGHGLIMALFALYLVLNEKKLKSFKGGGEMFETMFHGRYIILLMGVFAVYAGLIYNDCFSRSFNIFGTGWYFPNRTAYSDAALHSYDGDSDKTVNLDPKDTYGGVPYYFGIDPIWQVAKNKLNFTNSFKMKLSIILGVIHMMFGVCLSFFNHKHFKKPINIVCEFIPQVLFLGCIFGYLVILIFYKWIAFNVNRKTCPSLLLATINMFLRFGKSIEGKDSLYSGQDVIQPLLVVVAVLCVPWMLLLKPFYLRHQHKKLQAEVQETEGFHRLRDDGIDTVQHEGGGTVEHREDSQVEEFDFGEVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWQMVLHLGLPMKGALGIIATFGLFSLWAVLTIAILLIMEGLSAFLHALRLHWVEFQSKFYIGTGYMFKPFSFELILSGEADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JES9</accession>
    <name>A0A6P8JES9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein CfxQ homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574905.1">
        <property type="nucleotide sequence ID" value="XM_031719045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308583"/>
    <dbReference type="KEGG" id="aten:116308583"/>
    <dbReference type="InParanoid" id="A0A6P8JES9"/>
    <dbReference type="OrthoDB" id="5988235at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574905.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38007" checksum="C53FB6A7135F2B1D" modified="2020-12-02" version="1">MRGSQNTLKHLKNNKVVDIPKTIPEADLLRPENETLXGIEDYQISYFLFGIIIHSEQRDHYVTRKSSTTLKKPEFVGLTNLKEQFMRFTKTQVQNDRRRMLGHNVVENTPLHLVFAETPENQEEKSGRGPKVRSSGPVPGIHYKKKTKDKIDEARGGILFVDEAYSLIPTAGGKDFGTEAIEELMSVMENGDPIMIFAGYEKMMTQFLKVNMGLQSRIYRKIVFPDYTIEEVGKIFRQRVKERGYNLASNINVXKIIQEKTTEQQRSMMNARLMRLLLQKTIEEARNRVPLQASLRELLELQESDVVAAASHLPRYADDIEEVQREDTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ37</accession>
    <name>A0A6P8GZ37_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116286403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548783.1">
        <property type="nucleotide sequence ID" value="XM_031692923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286403"/>
    <dbReference type="KEGG" id="aten:116286403"/>
    <dbReference type="InParanoid" id="A0A6P8GZ37"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000042">
        <property type="entry name" value="Bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005966">
        <property type="entry name" value="D-Cys_desShydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01275">
        <property type="entry name" value="ACC_deam_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="42"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031548783.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42068" checksum="C22D1C50483304CD" modified="2020-12-02" version="1">MSTLIRTGFVIRRVFSTMKKLEPYEPPSWASMLKNIPTHYVKLAQRNTPIHPWYPPGLPSSFSLSIKRDDMTGSTLSGNKVRKLEFLLADALIKNCDTVFTCGGVQSNHCRATAVAARQLGLDCYLFLRHKEEDSSIGLPGNVLLNRLVGAKLVLXPNESYLKSLKPRMEKMAEKLRSEKGMSPYIIPVGGSNSVGVFGYITAFEELIQQNVLEDYDDIVMCIGSSGTAAGLAIGNYLTGSKLKCHAVCACDDATYFYQCINEELDALGLNVTAEEIIDIIEGYKGVGYALSTKEELEDIVRISSTTGVMLDPVYTIKSVRGMLSEMTNNPSRFNGRRVLYLHTGGVFGLYDGRMDSIIQDITAKSSPVTVWKDSLDNVPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H003</accession>
    <name>A0A6P8H003_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549749.1">
        <property type="nucleotide sequence ID" value="XM_031693889.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287239"/>
    <dbReference type="KEGG" id="aten:116287239"/>
    <dbReference type="InParanoid" id="A0A6P8H003"/>
    <dbReference type="OrthoDB" id="5988326at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549749.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28557" checksum="3C2B827E1A862B1B" modified="2020-12-02" version="1">MSTAGNSKQVLSTLEVRVLDSKKKSSYVVRSLPNFPVLETVSELRSELVKALPDLENVLQDCQLGYILARKKKISIVSTKDLEIAYGYFINGNQMWIDPALKNQNRANEDGGCTPGRKRSHESTVDQTTKHEQVIEIMDELKKMHGNVLPPYKFRLWAEMIRVGTAGKDSIPGLPMFTANPAKRPTKXETFVDVLTNAGTAIAGAIQTGSTQPSHTVTSNXAEVLKQLRELFQLKDMGAITDKEYKQKKELIMKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H254</accession>
    <name>A0A6P8H254_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Synaptic vesicle 2-related protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549481.1">
        <property type="nucleotide sequence ID" value="XM_031693621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H254"/>
    <dbReference type="GeneID" id="116287009"/>
    <dbReference type="KEGG" id="aten:116287009"/>
    <dbReference type="InParanoid" id="A0A6P8H254"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF45">
        <property type="entry name" value="SVOP LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549481.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="55350" checksum="328748ED49CECE10" modified="2020-12-02" version="1">MTDREDGEGEIGANSKGSNGNDCSLTFTVEDAIDKVGYGKFQLKLLFIIGFAWMADSMEITILAIMSPAIRCEWDLSTWEEATISTVVFAGMTISTCFWGFVADKCGRKKELIWCTILIFFGGFLSTFSPTYIWMVAFRGIVGLGLGGVAQAANLWLEFLPLKNRGGLVTVSMVSWSIGTCIEVGIAVVVMPNLGWRWLLLISSLPLIALLGLFKFIPESPRFLVSSGQFEKALTILQSVANENKEKLPPGKLVASSSSDQKVARGSIVDLFSAKYRRSTFLLWLIWFSSHFVIYGIALITTEMFSREDKCRGIIIDGSRADKETGCKILDTNDYLHYFVIMSSDMFGIVLCLATIDKIGRKNVQALAFAGSAIFLSALFICTRSRFVTTSFLYGARLFISIADLSGYVYTPEVYPTSVRGIGLGACNGVARIGCMITPFVAMVLMPAAVNISLSLYLGFAVLGVCAALLLPIETKGRALQVSLLLITKYTPEERLLVGLRNTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H290</accession>
    <name>A0A6P8H290_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Transformation/transcription domain-associated protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116287048</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031549520.1">
        <property type="nucleotide sequence ID" value="XM_031693660.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031549521.1">
        <property type="nucleotide sequence ID" value="XM_031693661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H290"/>
    <dbReference type="GeneID" id="116287048"/>
    <dbReference type="KEGG" id="aten:116287048"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549521.1"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115105" checksum="23A152DF270D6BA4" modified="2020-12-02" version="1">MASSTTPQLQHSTPEGIIKKCTTYANLLTEAAIADENKLKAAQEISENFETIVQSSSYPAFLEHAIPKFLLFLREGEPQFVAESTVQQIRKLLLEILHRIPTNEHLRAHFKSILSLMFHLLEIENEENVLVCLRIIIELHKQFRPPLQAEIQHFLQYVKTIYKELPVNVKQHFEVVSISATGFLPTESQGNNLPGASSQGNTPVGTPAASPMSSGDGGGGKTGQQTTIPKAISSLKVLAELPIIVVLMYQLYKQNVYTVVADFIPLVMNTIVLQPSLNARKSPTFNKEVYVDFVAAQIKTLSFLAYIIRIYQEMVNTYSQNMVGGLLGLLRYCPQEVAHLRKELLIAARHILATDLRNRFVPHIDQLFDEEVLIGTGWTTKESLRPLAYSTLADLVHHVRTHLPLPHLSLAVSMFSKNVHDDSLPVSIQTMSCKLLLNLVECIRQKSDEQGSGREILMRMLEVFVRKFQSIAKHHIPAIFKKCQQAADNSSSSSASASSTNSTTAQANTTTTTTTTSTTLSSTTSTTTSTMSSVGASLSTVGNGTSTTGGGLSTAGSTSSSSSETTTQSDQDTTTKKPLLHTSSAAISNTFSVPDCRSMVKTLVCGVKTITWGAGSCKVPGGNKPFLPLETQLFTRLLKYALQALDIYQVSVTANGQYFLRPPSSQQVRMKEEKEILEHFAGVFTMMNTSTFKEVFSSSIEYLVERIHTNYALQIIPNSFLANPNTSATFATILVKFLLERLDEMGTNMDRSNLYLKLFKLVFGSVSLFASENEQMLKPHLHEIVNRSMDLACTSKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNNLQSGVHRQYMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELFQALWKTLRNPNDNIAHVAFRVLGKFGGGNRRMLKEPQKLTFNEADTLGPCLAIYYPESVNPVTVSVGPVIERALAFLKTLPPNVSVLPQQSSINLDHTIFYRKQAWIVIKSYLVRKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2C2</accession>
    <name>A0A6P8H2C2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116287257</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549783.1">
        <property type="nucleotide sequence ID" value="XM_031693923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2C2"/>
    <dbReference type="FunCoup" id="A0A6P8H2C2">
        <property type="interactions" value="2803"/>
    </dbReference>
    <dbReference type="GeneID" id="116287257"/>
    <dbReference type="KEGG" id="aten:116287257"/>
    <dbReference type="InParanoid" id="A0A6P8H2C2"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000007">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="275"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031549783.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="57197" checksum="C073F8A7486FFD48" modified="2020-12-02" version="1">MVLLASAICTKSGKAIISRQFVEMTRSRIEGLLAAFPKLMNSGNTTKQHTFVETESVRYVYQPLEKLYMLLITTKHSNILEDLETLRLFSRVIPEYCRAMEESEIVENAFSLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFQAVRQTQEREAKEEMKKKAKELQAARVAAAKGRGGKMTMPGFGGFGSGTSRSEISAANIETTAVIDTTPAPKPTYPTRPAGSGKAMKLGSKSKDVDTFVDKLRSEGTEVISHKQKSVAKPAAAPVVNMSSVHLKTEEKITLTAGRDGGLQNMEIRGLVVLRISNSEVAKIKLAVENNDDKGFQLQTHPNVDKKLFSSENVIGLKQAGKSFPINNDIGLLRWRLQTTDESLMPLSINCWPSENDGQCEVNIEYELLQDNLELKDVVISIPVPHGVGGPVVGELDGEYHYNHKQSQLEWQVPVIDISNKSGSMEFTIAGHPEDFFPVNVSFFSSKTYCDVKVTEVTGVEDEKPIKFSQEVSFTAEKYEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H400</accession>
    <name>A0A6P8H400_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein KIAA2013 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550288.1">
        <property type="nucleotide sequence ID" value="XM_031694428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H400"/>
    <dbReference type="FunCoup" id="A0A6P8H400">
        <property type="interactions" value="1034"/>
    </dbReference>
    <dbReference type="GeneID" id="116287742"/>
    <dbReference type="KEGG" id="aten:116287742"/>
    <dbReference type="InParanoid" id="A0A6P8H400"/>
    <dbReference type="OrthoDB" id="10017443at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018795">
        <property type="entry name" value="K2013-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31386:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2510039O18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31386">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN KIAA2013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10222">
        <property type="entry name" value="DUF2152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550288.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69538" checksum="D3E31252A0DA931E" modified="2020-12-02" version="1">MWDKTRIGSLLGWVKTRLASSLLLRSRKATLVIFGLLLLFLIWSVSRLYPSHRRVKGSQRNNKYSALPFDGVCLGNFLAKWDSEVEQGNAIITHNPLQSHESPYIPFVGNGYLGVAAKKDSYLQVKDLTLMEVPYGPLLEPVMTTASTPKEATIIHLKNGKVHHIQSYLWSQSCVLVENVVFIHRSHPSLLVQEIHVTNHAEIPASVSLNQKGAKEWRKASTKSDSIKGKSGLVNYDIHHGNIAYVDENFPGVNVTIATTKKPETLNIKSRSSADIRHVAVVHTSIHSNEKVPAKNFDKDELEGLAKKDFEMIMKDFDPKEINNSHKSVWNKLWETGVHVDPRHDADTPPGIEVNATMYYLLSTFPTPDYNIHGNSQNSEEIESLLHAPEHCFGGPPTMHSASLWPIPRTEAAVARMMSSWKKVLTQNGCSSLIKAGGTGIAQAMTLSFGGLQFSAGLFEFAANPASLHTSVTFRHIHLYKGIFINVSVIINDHTGHAEKLFIQAKGNEKTPLYACEAGCQYEPVELSSSSVVFPVRMTKPVTPILYISKKKGQLQNIKKNVFIKDAHQESLKHHHVFHHVGLPAKFWVSIVFLIVAFHLYLVKLIYSECFKEPIRSKVYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5W8</accession>
    <name>A0A6P8H5W8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small ribosomal subunit protein mS39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116289031</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551769.1">
        <property type="nucleotide sequence ID" value="XM_031695909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5W8"/>
    <dbReference type="GeneID" id="116289031"/>
    <dbReference type="KEGG" id="aten:116289031"/>
    <dbReference type="InParanoid" id="A0A6P8H5W8"/>
    <dbReference type="OrthoDB" id="6021531at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055063">
        <property type="entry name" value="Rib_mS39_PPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22330">
        <property type="entry name" value="Rib_mS39_PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="repeat" description="PPR" evidence="12">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031551769.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33952" checksum="C75A65886E9EE6E4" modified="2020-12-02" version="1">GEKSTKSYFIFRDPLAVLKVLAGTVQPTALAPPRELFEDFGLYPKSPRKREECKIARTSGLKAADFILHKYPQLFPMRKAEPGWPDMNQGGAIETEQDLKDIIAEMKAQEAITGYEKLLKDGVPVSLQTRNDLLDLVAYYGTISAAEPVDTVKSGSLEGESSSSESSDESSSDEEEVENVRHKRTWSMDNYAEKLFKSMEDKNSRSYDAMILALLKHNYYERAFELFEHMREQNFQEFLFLYCILPSRKGDLSMYGFADGGKPDNSVKPSNQWRSQTESSYLHMMDPGIKPEIPRGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6V6</accession>
    <name>A0A6P8H6V6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551216.1">
        <property type="nucleotide sequence ID" value="XM_031695356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6V6"/>
    <dbReference type="GeneID" id="116288556"/>
    <dbReference type="KEGG" id="aten:116288556"/>
    <dbReference type="InParanoid" id="A0A6P8H6V6"/>
    <dbReference type="OrthoDB" id="5959495at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551216.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23503" checksum="EF70125A0BA00A15" modified="2020-12-02" version="1">MSSYKEPVKFYCPEEGCIKAYSCSRYLKQHLDIGKHEFKLTEESQLYDQIRQKWEQKCTSLKPPNPSCPPMVSSASNSEEVHVPDLVTGWALKKSKQCKRFPLHVKSYLVGQFLIGEDTGRKVTPAETSTRMRSMRDSNGKRVFDKEDWLTVQQFTSYFSRLAAMKKLGQLPPAPLTEEEEEEVEVAVRTTKRYDLRERVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7N5</accession>
    <name>A0A6P8H7N5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116288620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551298.1">
        <property type="nucleotide sequence ID" value="XM_031695438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7N5"/>
    <dbReference type="GeneID" id="116288620"/>
    <dbReference type="KEGG" id="aten:116288620"/>
    <dbReference type="InParanoid" id="A0A6P8H7N5"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551298.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="29431" checksum="08ED640EF01BB38B" modified="2020-12-02" version="1">MRAKLIEIYNYTHPGAAAQKQPQDNTSKTTKGPSLKQAKAPQRTAKPALKTLVSSSQPTRQPSKKKKNIPASQIRDSSDSDDDGYSSVRPASSQPSAPLKPSSYSTVKDPQGKFAGSIEDGSSSTSYSSQTGFPASRRLGNGRIESTSSLSEEDRGTGRGSGESNNEDEEEFGEASILIDKETDTASQQTTGDNLENKLLSFIESHRDVYLKVLTYRPIDLMALHELVKSSGIKCRLGQLIDFLDTQCITFTTAGQKPRQRRKPTRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8H2</accession>
    <name>A0A6P8H8H2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288825 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116288825 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116288825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551528.1">
        <property type="nucleotide sequence ID" value="XM_031695668.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551529.1">
        <property type="nucleotide sequence ID" value="XM_031695669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8H2"/>
    <dbReference type="GeneID" id="116288825"/>
    <dbReference type="KEGG" id="aten:116288825"/>
    <dbReference type="OrthoDB" id="5986675at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="54"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551529.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37741" checksum="389F353680B2BCED" modified="2020-12-02" version="1">MPDFSELSTGYKALAVVCCIGAFLLVVVLPMSFGDVEYYQIAFTKQKSTGKVDLSRVYTSGRYLIGPDYTFKAFRADAHVEHLKDIATYTDDKVEVTISCSIQYFLRPEDLSDLHQEFDLYYKPVVQSTVNAAIKSRAASISVAEFMRQRQSVENKIFKAVAERLGGKCCRKDCKTHKCSPGCIPYSKCSKSDKGLFVEVRYFQLLNFDIHEDVKSRYLRQVTEREQEEQAKFELEEQVVRKETDRLKNEILNEAAEIQQNSTATSTVIIAKAEAKALVEVEKARNAGLSKVFSDLNITSETHKASYIYLTALRRQHHARINVNYGTLMARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8L5</accession>
    <name>A0A6P8H8L5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289103</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551851.1">
        <property type="nucleotide sequence ID" value="XM_031695991.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289103"/>
    <dbReference type="InParanoid" id="A0A6P8H8L5"/>
    <dbReference type="OrthoDB" id="5947409at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="156"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551851.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="49303" checksum="8EB56DFB7068CABC" modified="2020-12-02" version="1">MQFDKDYPFSAKNESVNMAAVRIKNDQWKEDELLKEALKRYVEEGLHREEILDYVXRDFGEYAWSIRTLDRRLNHFEISYTDRTVTIDEIQSAVKNEMQGPGKLLGYRALQKKIRQVYGLKVPRDVVYAVMYDVDSDALERRAPQFKKKKAKGHFTSPGPNHVHSLDGHDKLMGYQNWTFPIAVYGCIDTCSRKVLWVKVWITNSDPQLIGRFYLEYLFKTRTIASRLRLDKGTETGVLATMHAFLRQNHGDMDPVETVIYGPSTSNQIERWWRELHERLEMFFKFPLKQLKDHGHYDPNNESHRHLLAYLMIPIMQKEINTFVDTVWNSHRIRGQKTTYLPDGVPNHIHDFPEKYGLQECGLKVTEQQLEEVADLSDVLTDNDDYLPPGLRVKCEQIIDPLEIDVSDIAHAFRYLKDNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8Q2</accession>
    <name>A0A6P8H8Q2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TNF receptor-associated factor family protein DDB_G0290931-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116288895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551618.1">
        <property type="nucleotide sequence ID" value="XM_031695758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8Q2"/>
    <dbReference type="FunCoup" id="A0A6P8H8Q2">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116288895"/>
    <dbReference type="KEGG" id="aten:116288895"/>
    <dbReference type="InParanoid" id="A0A6P8H8Q2"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="10">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="10">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="9">
        <location>
            <begin position="285"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551618.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49512" checksum="A8E589AC280EBFFE" modified="2020-12-02" version="1">MGLKPDQFVKGVDENLFCAICHEVFQDPVSCKDGHTFCKDCIHEWLKTNEKCPMDNGFLTKEHLVRVLMASGIIDNLEVYCHPRTTQHKPSEGCDWVGKLQHLTQHRKTCPFQEVQCSHVGCNQTMLRRELEHHEEICDFRKVECEICGVAILQHEKDKHTRDDCLQALICCPNRCSDKLQQLLIVKVKRINMPDHLSNVCPKAQVDCPYKEQGCEVNVERQDVEKHVQENMAEHMMLLAKECSSLKKQCSFLSLRCSTFAQENLELKNELQQMKDEFHNQLLGNSSYTWVVRDYPNLAKNPPNGPSIKSPPFWLRGNKWCISLYPNGNTKDETGFVSLFLKKIEEDSQSLSNTMPITSHNETEIPYRLTVISQKPDTDDVSRESKSIFTEPKNTWGWTKFMKSSDAFSPSYCNNGRLIIQCTILPNKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA49</accession>
    <name>A0A6P8HA49_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transient-receptor-potential-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116290433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553324.1">
        <property type="nucleotide sequence ID" value="XM_031697464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290433"/>
    <dbReference type="KEGG" id="aten:116290433"/>
    <dbReference type="InParanoid" id="A0A6P8HA49"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="11">
        <location>
            <begin position="90"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031553324.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="71867" checksum="30EF3C0CF2C20232" modified="2020-12-02" version="1">MNAYKCVKVIVKIVKNSFDEDDVGPAQTKREGFITPLMMALQLNYYDIVEYFIAEGYKIEELEDEETGEKSKNNLNIDLVKITNTFGIRMKSKHPRNSFPKEHKVLFKINTYQAKANPLYICYMFIHEKTSVNPLFEIFRLNQVLIKQSSLDEEFKEHYKEESEKCEDFAVDLMEQCRTFKEIKMLTDVIPEFEKKKRHVQIKKEDARDLTFLNLAIKGGNEKLVFARWMDVCMCVCVSDSVPLILFRVDWIILVWIMGMIFQEFKELWIQGKRRYFGQWWNAVTFLMMAFFVGSYSLRLIAYGITGNWAVLDPIKGFGFSSWYQVILLSNSLFSIGMVLSFIRLSGAFQANDILGPLQLSLYHLILDVFKFMVFFVLIFLAFGLSLRKLYSHYISTQMYMTKQRRALNSTNSETEHKFSDVGTGLYGLFWSLFGLTDLQNFSTKDENFAITKETGELLFGVFQVLAVIVAINMLIAMMTRSFDEIASNATKKWKVSRTSLWMFWVEKGSILPPPLNLIPNVHYLYQQIKRMVKSCEKETFDVDITDGFEHELEESGQSSGESKRHRKLKDILKRYIATRKITDNVHPRDEELRRQTSLLQELKXKSGDKTSKTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBG8</accession>
    <name>A0A6P8HBG8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031552966.1">
        <property type="nucleotide sequence ID" value="XM_031697106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290089"/>
    <dbReference type="KEGG" id="aten:116290089"/>
    <dbReference type="InParanoid" id="A0A6P8HBG8"/>
    <dbReference type="OrthoDB" id="5945116at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000139">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF873">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="89"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="308"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="459"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="565"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031552966.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="66357" checksum="0BE875DA03610FEE" modified="2020-12-02" version="1">MRTLKFHFITFLAFSREASGKMEWLRGLIFISCALCAFGLNSPRPPSSPSSVEEVAASRSSFPMPGDIVEGDIVLDDNTAALLRGGARNAMANVNKWPNGVVPYILDSSVDDYLRQQIDIGIAEYHKYTCLRFVKRTVEKNYIRIVKPASGCNSMVGVVGNGEQILNMGPGCEYVGLVLHEFGHAIGYFHEHNRPDRDNVIEVLWDNVQPAFKSAFKKYTFQEADTQGYSYDLTSIMHYENSAFGKAGFCKTTIIVRNNPSYEVRPVYERGVFSPQDIKKINKLYGCPMKGLPDVVKPGTNNPDPNACVCEDKHAECQSWKDRGECGNNNAWMSSNCPKSCRVCGEPDSDCKDEYPQACSDWSSQGECQANPTWMGNNCKKSCNKCSTTGTLPPQTQPPSTLEPTTEPDDNCTLIPDTPPPPTPPPQTPAPPTPPPPTPPPQTPAPPTQSPNTPPTGDCKDVYPAECPKYKSWGWCTRQDRLDXMKEVCSKTCKFCGGTTVTNPPSTQSPPTGDCKDVYPTECPNYKSWGWCTQQDRVDYMKQVCSKTCNFCGGSTGGGGGNGDCKDVYPQYCPDYKSRGMCTDPNYVDYCKEVCKSTCGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCH2</accession>
    <name>A0A6P8HCH2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:56784"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="3.4.19.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031554139.1">
        <property type="nucleotide sequence ID" value="XM_031698279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291157"/>
    <dbReference type="KEGG" id="aten:116291157"/>
    <dbReference type="InParanoid" id="A0A6P8HCH2"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000024">
        <property type="entry name" value="Folate gamma-glutamyl hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028028490" description="folate gamma-glutamyl hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554139.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36983" checksum="EB3E1F1A3153C9B8" modified="2020-12-02" version="1">MRFLFIYLVLIADIFCFLVQSKPAGIVKTKQSDSINNRPIIGVLAQETVGILKKFGKSYIPASYIKYLESAGARVVPIRNNLTETELKNLFSSLNGVLFPGGDVDLWTSGYAKTATIMFDLAVKAKDAEDIFPLWGTCLGFQMLHVLAAKGKNVITRCHAQNVSLPLNFTKDYKSSKIFSQAPQDITTYLGKLPITLNMHQNCVSTETYXKEPLLQKFFKVLSTNEDKNGKVRFASTVEAFNYPFFATQWHPEKNQFEWPTEENINHSKEAIISTQYMANFFVNQARQSKHTFASKKEEDAELIYNYKPVPCLPDVTHYELCYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDY9</accession>
    <name>A0A6P8HDY9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bcl-2 homologous antagonist/killer</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Apoptosis regulator BAK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116290383</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553263.1">
        <property type="nucleotide sequence ID" value="XM_031697403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDY9"/>
    <dbReference type="FunCoup" id="A0A6P8HDY9">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="GeneID" id="116290383"/>
    <dbReference type="KEGG" id="aten:116290383"/>
    <dbReference type="InParanoid" id="A0A6P8HDY9"/>
    <dbReference type="OrthoDB" id="6020735at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097145">
        <property type="term" value="C:BAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000007">
        <property type="entry name" value="bcl-2 homologous antagonist/killer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020717">
        <property type="entry name" value="Bcl2_BH1_motif_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF41">
        <property type="entry name" value="BCL-2 HOMOLOGOUS ANTAGONIST_KILLER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01080">
        <property type="entry name" value="BH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="16">
        <location>
            <begin position="82"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031553263.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25135" checksum="27E2C50986D6A41E" modified="2020-12-02" version="1">MASGGDNSDDVSPADIPEEQEREVVRDTEGVFRTFVYRRFQEETERGDDEVQFDSARSDALEELRSFNDVQRHDINRIGQRLGEVGDEIDAKYRDQFHDMIDSLSLTSDAAYETFAGVARRLFRSGINWGRIIALLCFGYEIAITVIRRGFSGSFLRRVIRFIVDFIFRERIARWIAEHGGWVSVLDFRLSEPSWYTVGTVIIIGVLVSVWAVRRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE91</accession>
    <name>A0A6P8HE91_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Glutamate receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116288246</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550875.1">
        <property type="nucleotide sequence ID" value="XM_031695015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288246"/>
    <dbReference type="KEGG" id="aten:116288246"/>
    <dbReference type="InParanoid" id="A0A6P8HE91"/>
    <dbReference type="OrthoDB" id="5958147at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000143">
        <property type="entry name" value="Probable glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027813495" evidence="19">
        <location>
            <begin position="25"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="765"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="391"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="401"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="695"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031550875.1"/>
        </source>
    </evidence>
    <sequence length="851" mass="96897" checksum="B65052CDCF045A07" modified="2020-12-02" version="1">MRRRTSVELCLILIILLAINNAKGKNFLLELLNTTTRDERDAAKQAVDDINSQLVANGSSFTLQIRNTSQKSDLYTYSSSLVSSDVIALLDFNTLPHSACEVSTITKIPIIRLHGSGNYKIREACNAIIMSADYDSYSQATVQILDAFQWKKIALMVEASRFYEAFFFKTLTANKDYTSVYIQIKHDEINVHKNECSCERIMKELAASEADVVLLFANEKSSILMMDRCNPSKTYVWIIQDLVLQDVLTAESSHMVVGFGLTTNVSAKWNSKRDNFDLVYDAILLVAMTLKNLHDNGMWLTGNDSATLSSXRETFYRYAKQMQVNKNGLVSPVRFDTKGRRVLNELRILNLINNTFTEIGKWTKAGNILEIMDRIHFNDKSLDGSLLKGREISVVTAVTDPFVMRRVSSEGTVTYHGFCIDILKKLASDLKFTYHIKLVDDGYYGALINGTWNGMIGELIDRKAEMIVAPLSKNVERQKYVALTASFMYYTDDMMMKKTVVAEREFFQFMAPYTTNVWTVVAASFVAVSLAVYILNYFSPYGYKNEHGSKTSEELNLINSFWFTAGSMLLQGTDHAPKSTSGRILAGFFWFSILVWLSTYTANLVAFFTVDIFIKPVTNFEEAVDSNYDLGVLEKSNLHSLFLSADYEIYRRAWNKMKRLPKNDSESIEWMRSGSPYIHILDGPVLEYVAQKQPCDLFTFPGLQSPRSYAFALRHEDPHLQEISLAILRLRESGFIEKLRYKYWEGTNECPDINTNRLKQKSIELYSLAGVFIVLAAGFLVSFVTLATEIYWHRVGRQRFHFLKEKTRNICRERSPKMANEKDDNTITQSDTISNSQASLGSLSSYTIRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEH2</accession>
    <name>A0A6P8HEH2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Receptor-type tyrosine-protein phosphatase mu-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554824.1">
        <property type="nucleotide sequence ID" value="XM_031698964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291756"/>
    <dbReference type="KEGG" id="aten:116291756"/>
    <dbReference type="InParanoid" id="A0A6P8HEH2"/>
    <dbReference type="OrthoDB" id="5989348at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF5">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554824.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23634" checksum="665D89B3E382C7A3" modified="2020-12-02" version="1">MVQTTKKREVXLKWQKPESVTEAIKSYTISFEGQKDYNRSFVHSDSLSVSSTTIEVPNLYPGTRYTFQVSATTECGKGDYSLSSSSNTKVDAPPAPVVGFVGNITAEVNNITVWESSDINGQIKAYQIIVVQVDKTTSIDETKLKSYEEAEKEELHYYIAAEIRTNHGNKFPRIFNLGDDKEYNAYQNVKIKDGMKYHVLQRALTQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEY3</accession>
    <name>A0A6P8HEY3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Hemicentin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC116290630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8 9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553568.1">
        <property type="nucleotide sequence ID" value="XM_031697708.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553569.1">
        <property type="nucleotide sequence ID" value="XM_031697709.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553570.1">
        <property type="nucleotide sequence ID" value="XM_031697710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEY3"/>
    <dbReference type="GeneID" id="116290630"/>
    <dbReference type="KEGG" id="aten:116290630"/>
    <dbReference type="OrthoDB" id="5985519at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653030" evidence="4">
        <location>
            <begin position="17"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="119"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553570.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="46880" checksum="BF3AEFEC859F4E16" modified="2020-12-02" version="1">MLKLCVFLFFLGAATGVPPSPKFEFLDPKKMTMETVRLGSSIIIDCETTDASAMVTLWKLKSSKEFQVKPSLDVIQSGQIFTKHNIDLQDAGQYKCKAQDSMGTKITKDVTIIINTYKPGLVLRPTNPVVTLTGSTVSFTCEAVIGTISWRFVSSGLRTYPPPSKYTIKNIVNASISLSVLTIPNAQVSNSGIYECWLYHFDASFFRNVDLLVKDSQRPAFTNGNSQTEIMTVKLGHSKHLNCEVTGFPTPVVSWEKNGRPISPCNRMFINFCQDSPYLSQPRGIKIDAARFPEDNGTYTCVANNSVGASRKDFQVVVEVKPVLDKSSSLLMGSSKVTCHAIKGNPPPKFSWSMQLYWFPTTKSPYKNGWKPISKYGNTATVSSDGMTSTIQVPSLITRAFYRCVAVNDVGRDSHTIKMMRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGA5</accession>
    <name>A0A6P8HGA5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrator complex subunit 4-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Integrator complex subunit 4-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116291791</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554860.1">
        <property type="nucleotide sequence ID" value="XM_031699000.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554861.1">
        <property type="nucleotide sequence ID" value="XM_031699001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGA5"/>
    <dbReference type="GeneID" id="116291791"/>
    <dbReference type="KEGG" id="aten:116291791"/>
    <dbReference type="OrthoDB" id="18190at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000728">
        <property type="entry name" value="Blast:Integrator complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056235">
        <property type="entry name" value="INTS4_8HBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24493">
        <property type="entry name" value="INTS4_8HBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS4 8 helical bundle" evidence="3">
        <location>
            <begin position="621"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="4">
        <location>
            <begin position="838"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031554861.1"/>
        </source>
    </evidence>
    <sequence length="986" mass="110242" checksum="92B00075E86AE5FC" modified="2020-12-02" version="1">MKRAVEEVSTTVVEEQLEFGAQPQQQPLLKLKRPKQLISSARRLLNELDNFTSTQDILRPLLELERSLPLDNLEDNEAAIRSLWERVFECKDVVVKAKLISLIGDLARYPGANALAVVDEMMRLLSTEESHKVNAQIIHSLTSLGKLYSHDNKLIQMLVSIAVEHLKDSHHAVRRECLKLIGHLGSTESPMTESNEQSTVSIQGLIMSFSSDSDPRVRTSALEALLTLHERGQALDVALYDKVSKTLEDDYEDVRMAAIKLIWVFSHICPERIVQLPTSDDARLVDDAFIKICNMVNDLAMRVRAEAVGLLGSLHHVSPKFLEQTLDKKVMSHLKRRKTDHEKKKERFAAGESSVGSWSTGRNWGDGNKQEELAPDEVSLMSSGACGAFVHGLEDEYLEVRMPAVDSLCELANQNRSFATLCLDFLVDMFNDEIESVRLNAINSLRKVCHHIQLREDQLEVILGVLEDFSWEIREAVRELLSHCHLSTRACLHAAIHALLGNLAKYPQDRASIWRCAKHLGSKHKHLASSLVPELLSTHPFFATSEPSVDDPAYVAIVILVFNATVDSPTMIPMFPNHTRRHYSYLRDSHPDLVPHLAIEAQSMEAQGVPAPQGPGSSGVSFMEGILRRIQSVSSMDPVNAQRFLSSIIKDLNHTKGIDDQYVASSRCMALYLECQLVVLQAQNDKIWNIPGPLCATRGTGLKSQVQKLLMTSYNIEHVFHGLNASQVLLLHEIRIIAHSLQILATQRCDTGTEKSLGSTLLVWQSFLARIRHYSALVGTSGTKLDEFGQALLSFQEFFEANITKPSCIADYLQSFILTRRVKCLELTSHLQQASAILTEPQGGSENPICFSAGLTFGINIDARLENIAHPTCVRVQVVFPDMRRQLFTPKYEDLHRLSNLRHRLVTTVVLSHSAWTEAGFIEVSLVTKYQPDVDEENVVSLGVINTDSESKTLRQIKNSTDNLEESVVGLCPPVRICVLPKPAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGD0</accession>
    <name>A0A6P8HGD0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione hydrolase 1 proenzyme-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555464.1">
        <property type="nucleotide sequence ID" value="XM_031699604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292320"/>
    <dbReference type="KEGG" id="aten:116292320"/>
    <dbReference type="InParanoid" id="A0A6P8HGD0"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="437"/>
            <end position="438"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555464.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="61752" checksum="0657DD75434DF577" modified="2020-12-02" version="1">MVKIIFPNDYPRIHTSGGPYSNGAVATDSEDCSKVGANILIDGGSAVDAAIASMLCVGVINMHSTGIAGSGFMLVYKRNTRETRMINFREKAPGASTRNMFKNNADHSKFGGRAIAVPGEVMGYYDAWQQYGKLRWYRLVQPAIDIARNGFTIGIPVYEAAHKQEDKLKEDPGLKELLFDKEGRLLREGTTITNEKYAKTLEQIRDNPHSLYNGPLARDIIDDMKDVEPKGLLQMEDLRNYSTEIVNGFSRRLDNGHVLHTTPPPTSGPLINLILNILKGYKMTAKDISNVNDNASSLAYHRIAEAFKFASAYRSLLGDPDFVNVSEXVRDLLDPKTGDFLRQKIWDNTTHNVSYYAEYFTKVDYGTSHLVVLAPNGDAVSLTSSINYRFGCMFRSKRTGIIYNDGMADFDNPGDKKINGIYPSEVNFPEPGKRPLSSMTPVIITDNDGNVKFIAGASGGKKILTATALTIINWLWFDRKISSAVDCPRIHTHLVPNNTLIVEKKFPEEVKKGLEARGHKLQDLKYYAAVQAIEKRGKKIYAKSDPRKHGKPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNE5</accession>
    <name>A0A6P8HNE5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116291198</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116291198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554195.1">
        <property type="nucleotide sequence ID" value="XM_031698335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291198"/>
    <dbReference type="KEGG" id="aten:116291198"/>
    <dbReference type="InParanoid" id="A0A6P8HNE5"/>
    <dbReference type="OrthoDB" id="5986870at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028387936" evidence="3">
        <location>
            <begin position="24"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="230"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554195.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42831" checksum="AE7C7421ADBEAFF5" modified="2020-12-02" version="1">MRKMIAVTFYVLFLTSIVAFVEGENNLRWPEGKYGLPNTIYGCPMADGFVWATGNITQALDPNSKTSNSFHLKAXVNKKGVQRSFCIKDTDPLDPARTAWPAGRYCIYRKGGKCPAGLKAGSLIWNNRMDFSYTKSSGVVPDGRSTFSNTLIHFCCAVNGDKNTPIPLPLESPFFLLAFLSSACQEVRGALHRAEFIYYNTDGQNSLNPPYPYGAGIYSMNITYCYYQACRSNLTALNGTIMSPFYPSNYPSNADCRWKVEVPVGYVITLEFEDVDMEPSASCMKDWVRVSTGSPGAVSSKYCARGNYPIMETRSNVVVLDFHSDEVTSLNKGFRIYYHAKKIPGNYDITRMRLKGGRMDGWIWVEGCMEKIKEGRRKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNM2</accession>
    <name>A0A6P8HNM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RYamide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116294494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557974.1">
        <property type="nucleotide sequence ID" value="XM_031702114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNM2"/>
    <dbReference type="GeneID" id="116294494"/>
    <dbReference type="KEGG" id="aten:116294494"/>
    <dbReference type="InParanoid" id="A0A6P8HNM2"/>
    <dbReference type="OrthoDB" id="6022667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="157"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031557974.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48367" checksum="A10CEF2DC9BD7CB4" modified="2020-12-02" version="1">MNGIESIMGAATWMTKLAEDTAFSPSTRATVSTRLTTASNSKSVEIAPSESFNQGFQMKSTSLSESVLGMTFNIATVVQTSRKTQALWNSLPTISILDVRGSATLEKINSTPSSIFVNASLPSNTSSFDNATEPYRRPVDDYSIVFYSIAFIAGITGNVFVLVDAFKTQKKLKTNEMLLIHLCLVNVFILSTLTPMVFLMKIRISSSCHVIFSLTILYQYGIVYTLTAISIQHHRAIACPFSPKPSGKRIAFTIVAIWVVSIFQVLPMVLTEDFLPRGCLIGTNKQLKIVRRKIYYSLLTFTQYLLPFFLIVMYYTKLSVFLKKARLDIERRTDSTHEVQSPRKKRNQRVVMVIVAMVATFAVSMLPQHIQFLLTEFVLEKTFPYGIAVFTFYPVVIKACLDPLIYGAVGRKLKSCSCCSRPTNSTQNDRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNX3</accession>
    <name>A0A6P8HNX3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Activating signal cointegrator 1 complex subunit 3</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116291320</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="RefSeq" id="XP_031554350.1">
        <property type="nucleotide sequence ID" value="XM_031698490.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HNX3">
        <property type="interactions" value="2434"/>
    </dbReference>
    <dbReference type="GeneID" id="116291320"/>
    <dbReference type="KEGG" id="aten:116291320"/>
    <dbReference type="InParanoid" id="A0A6P8HNX3"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000028">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000113">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058856">
        <property type="entry name" value="ASCC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26582">
        <property type="entry name" value="ASCC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="533"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="751"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="1383"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="1592"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031554350.1"/>
        </source>
    </evidence>
    <sequence length="2228" mass="251898" checksum="6A850B6533582538" modified="2020-12-02" version="1">MGYTSVTRCTVSIKERLPVVVTSGAICVLISEMNVLEIPRLTGSLRAFSGLSLSSHVTDSEGHELVRKRKIRAKKQREGELNWTELKTAIHDCIVDDSNAKTEVKILLRELLQTTKEIYGAEADIEALQEAAVSLFDILKGCEQLSQTESAKIRSLFGAFPASSGTKLCHIIQSIYHLISSEKLAQILRNKKSKENNEQLAEFGEGIPFFQPEIRQREGEEEWSSSSDEEGESVLDTFLRINHEQSSKKKEEKTDQSSHSSVNQSWLMEECQKHSVSTEGGLNAEDLFSALFEMLSSERNNEAIQNDLLELLGFDAIDLISKILQERYNIVTSILDGGHESVGQGKEYIKRSKNTSTRPDQSQPKYGCQVVIQSEEEKLLMKQARKEGRRQARRDKGDGDDGVDQETYLKELGFDPEMLAAQRESALFHASSKSLFSKTERQTRPREIYPHVYDEAHNAQAAFGFVAGTKICLPTTAKRKITKTYEEVSIPHSQNVAVVAGERLVPISELDEIGQAAFKGMKSLNRIQSIVYDSAYNTNENLLICAPTGAGKTNIAMMTIVREIKQNIEQGVIRKDKFKIVYVAPMKALAAEMVRNFGRRLSPLGISVRELTGDMQLTKAEIHKTQMLVTTPEKWDVVTRKSTGDVALAQLVKLLIIDEVHLLHDDRGSVIECLVARTLRQVETSQSMIRIVGLSATLPNFMDVACFLRVSPYEGLFVFDGRFRPVPLGQTFIGVKGTSSYQVANEMDKVCYDKVLENVEKGHQVMVFVHARNATVKTAMVLRELANNHGDSKCFRADQDPQFGAAEKQVTKSRNKPLRDLFPDGFSTHHAGMLRQDRTLVEQLFSKGLIKVLVCTATLAWGVNLPAHAVVIKGTQVYDAKKGSFVDIGILDVLQIFGRAGRPQYDKFGEGTIITTHDRLTHYLSLLTRQTPIESTLTASLADSLNAEITLGTVTTIDEAVKWLSYSYLYIRMTVNPLVYGISYKEKEDDPLLENYRRKLVVESARKLDKAQMIRYTEKQGYLSPTDLGRTSSHFYIKCETIETFNERFGPNLTLPEILEMLSHSLEFEQVKVREDEMAELEEHLHEDCLVHPVKGGVENSYGKVNILLQTYISRGHVESFSLVSDLAYVAQNCGRLVRGLFDIALRKGYPTLAVRLLTLSKTIDKRLWHEDNPLRQFTILGPEILNKLEARRATIPILRDMRADDIGHLVHHVRMGQTIKSCVKRFPSISIAASIQPITRTVLRVRLTIRAEFEWNDKLHGNTEPWWIWVEDPDRQHIYHSEYFLLHKKQVLSEEDLSLVFTIPIIEPLPPQYYVHAVSDRWLAAETVCAISFQHLILPEKHPPHTELLDLQPLPVSALNNVSYQMLYKFTHFNPVQTQVFHTVYNTDHNVLLGAPTGSGKTAVAELAIFRVFEKYPGSKTVYIAPLKALVRERIEDWKVRFGQKLGKRVIELTGDVAPDARSISQADVIVTTPEKWDGISRSWQTRNYVRAVKLLVIDEIHLLGDDRGPVLEVIVSRSNFISSHTENKVRVVGLSTALANAQDLADWLDIGTAGMFNFRPSVRPVPLEVHITGFPGKHYCPRMATMNKPTFKAILTHSPDKPVLVFVSSRRQTRLTALDLIAFLAAEDNPKQWLHMPEEEMDFILRSIHDNNLKLTLSFGIGLHHAGLHEHDRKTIEELFVNQKIQILIATSTLAWGVNFPAHLVVIKGTEYFDGKTCRYVDFPITDVLQMMGRAGRPQFDDQGTAVILVHDIKKHFYKKFLYEPFPVESSLLEVLPEHLNAEIVAGTISSKQDAMDYLTWTYFFRRLVMNPTYYDLQDTDHDSINAFLSELVEKATSELQSCGCLQIEEDNVTLSPTTPAQISSYYYLSHLTMRMFSEELNADCSLPDLLKILADAEEYTQLPVRHNEDALNKELSEHLPLEVPPHSFDDPHTKANLLFQAHFSRVGLPISDFLTDQKSVLDQAIRILQAMIDLSADEGWLATSLRIMHIVQMVIQGRWLQDSTLMTLPSISDQHLPLFVGPRREPIESLPELLDFVGSDPEALAKLLRGSFSANHIEHLLNIVKRLPVVGISVKLRGAWADGDGAQQEERPLDIETLEGRHDNWSKVHADQEYSLNIELKRLNRFKGSELKAHAPYFPKAKSEGWWMVLGDTDSGELLALKRIGNIRSSTRATLSFYTPEIEGRKIYTLYLISDCYLGLDQQYDLYFEIVESSIVSQFITEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP20</accession>
    <name>A0A6P8HP20_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">UbiA prenyltransferase domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554395.1">
        <property type="nucleotide sequence ID" value="XM_031698535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HP20"/>
    <dbReference type="FunCoup" id="A0A6P8HP20">
        <property type="interactions" value="2239"/>
    </dbReference>
    <dbReference type="GeneID" id="116291365"/>
    <dbReference type="KEGG" id="aten:116291365"/>
    <dbReference type="InParanoid" id="A0A6P8HP20"/>
    <dbReference type="OrthoDB" id="203513at2759"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000005">
        <property type="entry name" value="UbiA prenyltransferase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554395.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35224" checksum="A331AAA357BA057D" modified="2020-12-02" version="1">MNGKSYKEAINDVKNDKYTKKHSRFGSYLLALRPWSFSASLIPVVLGALLGWKTTGELNILLTLVTTVAVLCVHASGNLVNTYYDYLRGVDSKVSDDRTLVDHILTPDEVVRVGALTYVVASFCFLVVVSLSPAKMEHLALLFFGGLSGSFLYTGGIGLKYYALGDIVILITFGPLAVLFSYMIQCGQFASFPLYYAIPLALNTEAILHSNNTRDMDNDEKAGAVTLTILVGKHASYAVYCLLLFTPYVICVVWGVNISVRYCLPLLTIGFAFRLEKEFRDGKLASLPKRTAKLNFFFGLLYLISFVIAPRLPHIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ98</accession>
    <name>A0A6P8HQ98_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ERC protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558544.1">
        <property type="nucleotide sequence ID" value="XM_031702684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ98"/>
    <dbReference type="GeneID" id="116294982"/>
    <dbReference type="KEGG" id="aten:116294982"/>
    <dbReference type="InParanoid" id="A0A6P8HQ98"/>
    <dbReference type="OrthoDB" id="5970772at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558544.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36100" checksum="0997FD186C1AAAAE" modified="2020-12-02" version="1">MDRKKLKVTKQKSDSSIALQKGPKSGNQFLQLDVTTLNSKSLSSLIKESKPESKNVETQTEFEDIVALHLEALKDEFERERAELEAELTKEKRNLEGKLRDYYAKILESKDILINDLTNEKDFLWEEMRDLRESCQVVNGNVEPAESSTDDLEWDHGSDSEISRRLEKKRGSERSKITNLSLSTQVKETLLWSVMKLHKQNLIEKYQKEKQALLDKIEIEKDLIREEISSELESNYQEEIKNLRETVTGLQEVLSDMKSQKSELAKIFEGEKNALKLEISRKEEELKQKMAKNMQRKVIQAHQDWSVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQF1</accession>
    <name>A0A6P8HQF1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116291837</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554910.1">
        <property type="nucleotide sequence ID" value="XM_031699050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQF1"/>
    <dbReference type="FunCoup" id="A0A6P8HQF1">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="GeneID" id="116291837"/>
    <dbReference type="KEGG" id="aten:116291837"/>
    <dbReference type="InParanoid" id="A0A6P8HQF1"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031554910.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24260" checksum="FFFC8AA3364A7FD6" modified="2020-12-02" version="1">LEDKVKLRDVYALTLRQGHMTNRRSSARVPQMKCVGGFAWCWVFVPKVALCHNKGSDGYRVQWECEADTGDRFGEIAVNCEGYDYPEDPYILEGSCGLEYTIDHVGGNSGNAYHHSSSYPHSNQHGNYGYKQHRNRVFPCSISTLIMWGIIAFIVYYIYSTCSANQHMTDSTQDTSQPSTYGTAPPPYTPPPPGFRPEYTQGKGGMRGKQINLIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR84</accession>
    <name>A0A6P8HR84_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294599</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558091.1">
        <property type="nucleotide sequence ID" value="XM_031702231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR84"/>
    <dbReference type="GeneID" id="116294599"/>
    <dbReference type="KEGG" id="aten:116294599"/>
    <dbReference type="InParanoid" id="A0A6P8HR84"/>
    <dbReference type="OrthoDB" id="6086616at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012444">
        <property type="entry name" value="DUF1647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31389:SF4">
        <property type="entry name" value="LD39211P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07801">
        <property type="entry name" value="DUF1647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558091.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44739" checksum="3944A32EE6028DCE" modified="2020-12-02" version="1">MSNLLRVGKKVFGFGIIAIILIVTFLFTVLPSRPVSENKKATEKIAQFQEKTELPKIELQQYVHPHNSSIKGIEFNLKKATAKTAQFQEKTELPKIELQQYVHPHNSSVKGIEFNLSLHIYSLAMQLMAQLESGKKVEKLTMDSLIEAMAPVTAISSNHFHELIAHLGDFHRFVPNKKLVVYDLGLTQNEVSSLKGIDYVEYRKLNVSVYPEHVRNLHSYAFKPLVIQQVLAERGGVLWMDSSVKIRMPYTKLLEQMVNSSSGFLYYLHPNRHNILSATQPRMFEYLPMNNLHEMKFNQPQATGFITFNTPEIRKFIFKWAILCSLVQDCIIPKGSTIYCGSKFPEKPASGCHRYDQSMFSILVRNEFGSETKRYIIGEKLDYADVNRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRW5</accession>
    <name>A0A6P8HRW5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294417</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557868.1">
        <property type="nucleotide sequence ID" value="XM_031702008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRW5"/>
    <dbReference type="GeneID" id="116294417"/>
    <dbReference type="KEGG" id="aten:116294417"/>
    <dbReference type="InParanoid" id="A0A6P8HRW5"/>
    <dbReference type="OrthoDB" id="10408392at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557868.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39045" checksum="811AE3669AE12601" modified="2020-12-02" version="1">MLQLLGSPFNLPDDMVSVLSSDTPLSTGSDLARAMDPPSPEPSPGPSPGVSPTFSPSASPAASPPSEVAKLAAWTPGSGGRLTSLPDATLDQMNKEELREYAEALKSLAEKYPQVKETLTPTIKNVMTRVDGRWRGNRSEKRMNLAEVEEYVKELEATDQSKFDETSQMRIRYALEKALARRLQLRKEAEQDRRNGGDDPEGDDGDGSDGGDGGGGDDDDDANDDHGERFKNADQDTVSKALRKKLGKGDHQTIANTTTVTTVRRGKRPVVEREHTSQTFPGPASDNDDDDDDDDGGGDDATIEGGVLRRKRKSRVSKSKPRRKKHSQQGGYNKTPHEVVDQYIRFLRDAKRKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTB1</accession>
    <name>A0A6P8HTB1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555872.1">
        <property type="nucleotide sequence ID" value="XM_031700012.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292661"/>
    <dbReference type="InParanoid" id="A0A6P8HTB1"/>
    <dbReference type="OrthoDB" id="5986588at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="3">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="787"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="3">
        <location>
            <begin position="900"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="5">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555872.1"/>
        </source>
    </evidence>
    <sequence length="1382" mass="157943" checksum="D4D040B7CDF56BC5" modified="2020-12-02" version="1">MAKHCNDISTTMNSCIQFVKLSNSIGRHAESLRCLKEMLPLVVGMLSSELIVHRHLSIAYMKLNEFENVVLHAKKWIKIAQTIDDKENEMYGHHEMGKALSFLARYDDAIDCGKKCLKIAQEIVSPEGMMDAYDCIMVAYKYMQKYDDTILYAHKLLDCAMKNNNQKIMMDAYLELGVAHCALNHYQDATDFGQKCIEIAREIEDRRGEVKAYLLMGQTYNALSDYDNTIIHCKKCIELAITIGDKDAEAHAYGVLGDIHYSKKEYDDAIQNFKKCIDIVKRFGLEKKEAATACLCLGPIYHKLDQYNDAVHYFKKCIDMAQETGEKKIEAQGCLGLSSVYRTLVDKESMDNAIQYGNKGLKISQEIGDKKNEMDGYHCLAHAYMGSFQLNEVFQSIDAGMAIATELGDKEAEENFNVICYSLYCTVGLQNKVDAPLVKELLEVPTCSEDELLQDRDQAVKTSDKKKKSRALMRLYNFYRSKKEYAKTINCLEQLKEMDFNCCVNLFCITQIGNLYHLMDQNDMALRSFKQGLPTAESCPDTDGYLPHFYYSFGKLLYFLNRELNFAEXYLXEAIRIFEAIFTALGSLDEFKISIFDKYVNSYKLLAILLIKDKQMEEALLVLDRCRARALKDLMMSNFKMKQEESNDEHLEYSDVLSLVSRNDFSIAFYSLCFNVFLKFFIEGETDLQFPICLNDSLQIQVDRLFNEMGVREVINCENRSLDKEEDIQKEQRRSKEEYEGLNQPTVLLLNLDSNRGESNENSAETKGSTLEDLFDILECERILSSKQDEVVIIPDGPLYQVPFPALRDPRTGKYLSETKRIRLAPSLATSKHFEDFPTDQTSDAKPLIIGNPLVGKVMMDGEEQDIDGLLGAQAEAIVIAYIDSAEGMMMAYDCIMVAYTNMQKYDDTILYAHKLLDCAMKNNNQKIMMDAYLELGRAHLALNHYQDATDFGQKCIKIAREIEDRRGEVKAYLLMGQIYNGLSDYDNAIIYGNKCIELAITIKDRRAEANAYSFLGDIHYSKKEYDDAIQNFKKCIDIVKRFGLEKKEAATACLCLGPIYHTLKQYNDAVHYFKKCIDMAQETGEKKIEAQGCLGLSSVYRTSDDKESIDNAIQYGKKCLEISQEIGDKNTEVAELQLLAIAYIKSNQLDEVSQSIDAGMAIATELGDKKAEEKFKEIRSDLYFRVGLLDKCDAPSVKELLEVPTCSEDELLQDLDQAVKTGDKIKKHRASIRLYRFYRSKKEYEKTINCLEQLKEMDLGPSLKLFCFTEIGNLYHLMGEKDMALRSFKEGLPTAESCPDTVGYLSDFYYSFGNLLYFLNRELNLAEHYLRKAIRIFEAIFTKLGSLDEFKISIFDQEIDSYKLLAILLIKGKQIEEALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUI5</accession>
    <name>A0A6P8HUI5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Follicle-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116295286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558928.1">
        <property type="nucleotide sequence ID" value="XM_031703068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUI5"/>
    <dbReference type="FunCoup" id="A0A6P8HUI5">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="GeneID" id="116295286"/>
    <dbReference type="KEGG" id="aten:116295286"/>
    <dbReference type="InParanoid" id="A0A6P8HUI5"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027634983" evidence="12">
        <location>
            <begin position="25"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="295"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031558928.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="68898" checksum="9A5014C26C693652" modified="2020-12-02" version="1">MKFGNYLGEIFGVTTLLLILHTEASMNFSNYSSCSDWCTCRHDNNGKIIVKCRLKETNFSRLQLPPLIDELDLSNNGLTKVPVEFLKRYTNLSKLIMDHNSIKVLPSRSFQFLSSLEILSIKYNSIYSIENSSFVGLHNLKSLDLAMNDLHFWKAHNLSRDLPVLQTVRITGAIFWVPDASLLKLPSLVEIIGVTWCKFCINCTLVKPVNILNESARREAAETCRERFYEYKYMQIGKPDPKRFLSHGFIPECMCVKETECEFRQLVMPYFQTQDSLPQYLFYLEYVISPFTILFNVIVLVVIVSRKTLRGIPSFFLIANMAFVDIIVGIYSITVAEVNIKEIEKILEELMWTGQKLRPSTGPIFIAGQLISVLISSILTVERYIVVVYCVTSNLKLSMKTTLISLAVAWGIAITFAILPIFGVAGLRYNIKRACAPLSYDVKYQSQSSTVLISMLILIVLIYFLNIPLYFRIFRFVKKNAGNAVSGVKKELSLARKIATLILTNFVFFAIPILLILIISIFSEYDNNPFDFSGDAFESTIFKIIIGQWLPVTCLNINALLDPFLYAFRHSIFKREAKALVFRYTGKVLPLDDSCTANPGASKSTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUP7</accession>
    <name>A0A6P8HUP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein FAM174A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM174 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556375.1">
        <property type="nucleotide sequence ID" value="XM_031700515.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293113"/>
    <dbReference type="KEGG" id="aten:116293113"/>
    <dbReference type="InParanoid" id="A0A6P8HUP7"/>
    <dbReference type="OrthoDB" id="5917722at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009565">
        <property type="entry name" value="FAM174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06679">
        <property type="entry name" value="DUF1180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027597003" evidence="10">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556375.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16136" checksum="EC05ECA19A8396B8" modified="2020-12-02" version="1">MAFSTIKCLLILLVIFAFEEHLFSQAXPTKPAPKPTPTPTAKHKNITHTTSRTLNSTESSHSGGSNTGFSFPNNKGLLKRMLYVAVGCSALIALYFIVKTIRTKSRKNKSKKYGMIFSSGDVEMQPLDNDDDDDDMTVXDRKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW67</accession>
    <name>A0A6P8HW67_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="12">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116293581</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031556885.1">
        <property type="nucleotide sequence ID" value="XM_031701025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW67"/>
    <dbReference type="GeneID" id="116293581"/>
    <dbReference type="KEGG" id="aten:116293581"/>
    <dbReference type="InParanoid" id="A0A6P8HW67"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05068">
        <property type="entry name" value="PTKc_Frk_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09933">
        <property type="entry name" value="SH2_Src_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000318">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000044">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="242"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031556885.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57790" checksum="0343ED98A1621384" modified="2020-12-02" version="1">MGCIQSTRRRELQKRKPVIKLDDVQNQPRDEINSREEGKDRKRFEVVPPVPTSLPPPERKVFIALYDYEARTAEDLSFKKGDKLEVVNDTDGGDWWQARSLVSNGVGYIPSNYVAPQTSLRREDWYFGPIRRVDAEKMLLMHGESGAFLIRESESKPGDYSMSIRDGDNIKHYRIRTLDSGGFFIAHRSQFQTLGELVEHYQKDADGLVIRLKDPCPAIELPTIPDLSYNTKDQWEIPRESIRLISKLGQGQFGEVWEGLWNNTTPVAVKTLRTGTMSPSAFLAEAQIMKRLRHPKLVQLYAVCTKEEPIYIVTELMEGGSLLDYLKGPGRALQLPQLIDMGAQIAAGMAYLEINNYIHRDLAARNILVGDKNIVKIADFGLSRLIDEGEYTARAGAKFPIKWTAPEAALYNKFTIKSDVWAFGILLSELVTYGRIPYPGMGNAEVLAQVERAYRMPCPVNCPGQLYQIMLDCWKQNAEERPTFETLQWRLEDFFAMDTTNYAEYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWL2</accession>
    <name>A0A6P8HWL2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Salivary glue protein Sgs-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557050.1">
        <property type="nucleotide sequence ID" value="XM_031701190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWL2"/>
    <dbReference type="GeneID" id="116293723"/>
    <dbReference type="KEGG" id="aten:116293723"/>
    <dbReference type="InParanoid" id="A0A6P8HWL2"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557050.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="14826" checksum="7B96437ABFE4C8E0" modified="2020-12-02" version="1">MSKPATSTTFGSKPAPATTFGSKPATSTTLMSKPATSTTLMSKPATSTTLMSKPAPATTLISKPATTTTFGSAPATATTFGSAPAPATTFGSTAITATSVSAVSSGFSFASPTVGTSIPSQTCEFGGDTGKESIQTKGNIKKGVRKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWV1</accession>
    <name>A0A6P8HWV1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293753</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557072.1">
        <property type="nucleotide sequence ID" value="XM_031701212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWV1"/>
    <dbReference type="GeneID" id="116293753"/>
    <dbReference type="KEGG" id="aten:116293753"/>
    <dbReference type="InParanoid" id="A0A6P8HWV1"/>
    <dbReference type="OrthoDB" id="10692631at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557072.1"/>
        </source>
    </evidence>
    <sequence length="981" mass="113735" checksum="ABF3938B6E85D251" modified="2020-12-02" version="1">MAEVLSIGVIVFLCTAAITTVLLIILYCVCRSEDPLLDHTCVAWLHSPRTVSKTKYDVLPLYDMQNGHNAPRDDKLGTIERLRVEEKKEKKEKPTRGVDVKRKEFYERYPEKCPLSIDDPNFHRSESSGRGKAVSREKGRDDERRRSHENHSRRSKEQWEPKSKSVHDIYVNEQYYLQSPPQTSRSLNFIDKYDERDGGVASSLYMHPPRHDEKSHHYVRPRSVERNDGGSNHSYLHSLLPRTLEREGRRGRRDKRESQSSSHYVRPRSLEPERKERSHSSHNVRPRSLEKDERDGIKRSHSSHYVRPRSLEKDVKDSHVSSSHYVYPQSLEDKTDSLYVNQPPPAAKEETRHKSKHPTRSKDDILHAKDNYYQNVSAINDDEQFLTKSREETPLLKASEEIAMSEVQQLSSGLPQRNESERQLDRHHQTGYKQEDRDRKRMRDGSERQSRPRSRLTEYRRPRSSHELFDVGWSDHKKGPKDNYFLPRTQSMISARPTKNDDSTIGRRHTIHLEFHPRSGDVTPVDSEKESGNKKNRPSIQQEYSPKEQREFSARRNIKKQDAIRAQQNYADHAQDTKRRQSKDKKSHIKPEVGKNGLTIPPRYDSVTDEYRSTLREDRMRASFTIPPRYDSLPDRYRDAGHEPRPLTTHSRDQNKRFTSRKTTLDEHRKLQSRKSTESTSSRATMESVHKEIESSSIYKKTDDGRLVLRDTSQEPSQYKGTRAPEKMPIKGPVEDTATQRTRTPEKIPIKGPSKDTETQRARTPDTIPREGPAEDTVTQRARVPPKRTKSIERVFYVKSVPRSEPMLNTETPLEVSSDEIVDWNLLKLTGQNIDVSEDERSQDTPYSAGDESNQLIQPNAALPSKGLSDKNIDWHLFSLNGQVEDHKSAVLNNPSQENGPTEPSHEVKQAIVTNHKNIDWHLFTIAGEKIDEKKTPTQDNMSTTSTKDSIKQSLETQIKYGEELHTSRRPKVKPMILHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWZ6</accession>
    <name>A0A6P8HWZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myoblast growth factor receptor egl-15-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116296098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559918.1">
        <property type="nucleotide sequence ID" value="XM_031704058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296098"/>
    <dbReference type="KEGG" id="aten:116296098"/>
    <dbReference type="InParanoid" id="A0A6P8HWZ6"/>
    <dbReference type="OrthoDB" id="5962987at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="262"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="269"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="346"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031559918.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46130" checksum="45663EE713F7AC07" modified="2020-12-02" version="1">MTHILILIGVTILVTCGICLCVAVLRCRRKNTKGKIXHRKKRKTKRKKLANDIVVISHEMYKEPSTFTLDRDTNEVAEELAPFTKFEVTCTLHNTDVPSMKTFGQRNNSVTSSNRNQDPTDNDIEGGVHIYQDIDQPQGPALPPRNSIKNRQESSKRNKSSLRKSSXGNETNMXSSKKYRREDSSXGKTSSTREIVQNEHRGETAKGGEGTTRKGNQDKSSPIYANKDCDSSGRISSKGCKTTSSSTSCXSESDWEVSPESVHLCDRIGAGSFGQVWQGLIGGKPAAVKMLNERASASDKKDLLSELEVMKTLEPHPNVVKLKGCITKATVTCSGSVFYPPLVFLELVPYGDLLGYLRKSRGEDDDYYSGKDLKAPKTPTPQHLFSFAHDVAKGMAFLAENKVTIEPIETRKKARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXD5</accession>
    <name>A0A6P8HXD5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116296211</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031560063.1">
        <property type="nucleotide sequence ID" value="XM_031704203.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HXD5">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="GeneID" id="116296211"/>
    <dbReference type="KEGG" id="aten:116296211"/>
    <dbReference type="InParanoid" id="A0A6P8HXD5"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000077">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031560063.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25186" checksum="CC0AB31E42351DAB" modified="2020-12-02" version="1">MNILTEERTKDXWRHNDAVCFDVDSTVVTGEGIDEFARFCGRGEEVAEWTRRAMDGGISFQEALDARLNIIKPSSQQVEDFISSNSLHLTEHIRELISTLTSKGSAVYLVSGGFKEFIEPLAKLVGIPKENIFANRLIFDDQGNYSGFDTNQPTSDSGGKATVVGMLKKRYNYKSLVMVGDGATDIEACPPADAFIGFGGNVVRENVKKNASWYVSDFETLLNELKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXX7</accession>
    <name>A0A6P8HXX7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of DNA damage checkpoint protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC116297185</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18 19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561219.1">
        <property type="nucleotide sequence ID" value="XM_031705359.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561220.1">
        <property type="nucleotide sequence ID" value="XM_031705360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297185"/>
    <dbReference type="KEGG" id="aten:116297185"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT_MDC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_MDC1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom"/>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="15">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="1501"/>
            <end position="1579"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1250"/>
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        </location>
    </feature>
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        <location>
            <begin position="1295"/>
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        </location>
    </feature>
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        <location>
            <begin position="1341"/>
            <end position="1492"/>
        </location>
    </feature>
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        <location>
            <begin position="1689"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="512"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="838"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031561219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031561220.1"/>
        </source>
    </evidence>
    <sequence length="1720" mass="192492" checksum="DC57BDC3E580A55D" modified="2020-12-02" version="1">MDLDDTQALDLDEYDETEEEQEVKRNRKQVGQLKVFRTGDFEEKIYDIFEGENFIGRDERTDVYIPRKSLSKTHACIEVSEGLHLVYDDNSKNRTRRDKMILKPQVRYELHHGDMLTLADTKCQYFKGKMEQDNEDNDTGSETGSESMLPVGSAIHVSKGTSKEKDVFAADTDSETDDEKNPVNIKKPAMYSSDEKLPQIDAIENSEQPKPIVPAFMYDSSDDDDHGDDKHCTKSSNDIKTHADVSADSETLAFGLISPDDLPIIRPNSKKVPEVENTPLTLVYSPDTQDRTPDHPSILPKGKEEGSSCPPTLIYGSESPYQEKNPVKEKEGSSQPEYSNKRDFVKMSTDEPDTPDKMHVKTEIASCAETLPVQEIESLEETPVRDVEPTMLHGAGSLEETPLKDMPKLGETPSEFNVYLPETQGFSPGNEETSFCEPTQAYLQESPVDTPKETPGEMVSDVTSIPDSQEEEGEEEEVKKTLSYDDDTATQAYTWDNSDATDDGDDDELRFQATQAYPSLIQQPKKDDDDDDIQQGADVKDSSPCASSSPHADMQQTIAYDVAEMETQVYVTERENVSVDHTKGKGKHPEDKPVEIEPTLPYNIMDMETQAYEAETEETTSPASNSLNKSSTDDEDKGTPEELKMSAVVVGDRRGVTIEPTLPYDLETETQDFDNNEKDAQETSRQTSKKNAEDDNLVIEATVPYDMEMETQAYDRKDIDDSETDDECNLEKKEGNMADMMETQAYGDEVPVEARENAINTFNMADMMETQAYGVEVEALENAINTAGASDVNDADGEPQAYGLEDQATVTDDVIPDSEDLLSQEIPLKRISEDEDTVNNNASVKTPTIQHDKQQVEQSGNKEEEKEEEKEEAEIIVRPKRRGKSRVTHSSPEEENQQPAMLNKLEDTTTAKTAEDISLNEQATAPEDVGVQRSKRGKRSKKNKVETEIQDTLGDASEEEQFKIATKQEKSTRERKSTRGKTCKISKTDDTEIEQSTSMSEKRPTRGRRSKKSEVEIRVQGILPDDTEEEQSMLEKRPTRGRQLKKSEVEPSRVEDVLPDNTEEERQESPSTTKKRPTRGRPKKTVVKTAMIEDSLPEDTEKDEMSLQPVQTTHNEHLPEKKSLRGRRSMKTGKELDIEEKIKPVDNAEDKNKSESVPQKRVQQKMSTRGTKKDEEDRLEGTGSGDNKEKLDTCAENLDISPGHSEEEQFAVKHKGKGKDKKSLQVDQDSSCKDEEELPSLEIIFSDKKVTKGKRKGKTKDAETPVLLSGKDTSTAEAVRNEGMSFETIEVKPFFPRRGRGRVTQSDDSASAVPGSFGSELSEFKEEDFMSPQSVAKSISALKKEKKKKGEEQNLKETEMDINATQSNSSSPRGSKTRKRGKEVRTDLDESQSSVTSSVGREARGKGKGKKAKSTKVDDTHVHSASQASSDLSESQNSTASSGESRARGKGRRRTGKPSTLDDSQEQEVQETPVKKGRTVKQEDSPTVVHSPSLRERKPITPKIMFTGVSDKQAEKIVTSLGGILVDSVYECTHLITDKVRRTVKFLCGVASAQMIVQPQWLTACKKAKCFIEPVPFIVSDEAAEKQYSFSLQQSLERAKKGGLLEGYKVHITKNVKPDPSQMKDIIKSAKGEYLPRMPRTMENNILVVSSEEDRDLCKAALDCSIPVYSSELLLTGVLRQELDLDQNRLFTGEKEDRKRKESEDEETSVKSASRKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ01</accession>
    <name>A0A6P8HZ01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase RNF166-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116296617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560521.1">
        <property type="nucleotide sequence ID" value="XM_031704661.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HZ01">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="GeneID" id="116296617"/>
    <dbReference type="KEGG" id="aten:116296617"/>
    <dbReference type="InParanoid" id="A0A6P8HZ01"/>
    <dbReference type="OrthoDB" id="5951974at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051438">
        <property type="entry name" value="RNF_E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031560521.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24851" checksum="A439956B051995BE" modified="2020-12-02" version="1">MAFAGGSSSLTDDGKDLKCPICLEIFEKPIQISCGHSFCKDCIMGCLSKVSISQCPVCRTSFTTVQMKNNTRLANLINYTSETCSKCKQTVALSSFRKHKDTCTGTHDSKSCLVFKPVLPTSQPEPSAIPNRSTFKCPYCGTPNLVREDLIEHVIENHNQDVQQVVCPICASMPWGNPNQKSGNFLQHLNMRHKFDYDTFVDYNDEEDEILXAVLEKSRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZQ3</accession>
    <name>A0A6P8HZQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560766.1">
        <property type="nucleotide sequence ID" value="XM_031704906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZQ3"/>
    <dbReference type="GeneID" id="116296812"/>
    <dbReference type="KEGG" id="aten:116296812"/>
    <dbReference type="InParanoid" id="A0A6P8HZQ3"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028190181" evidence="1">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560766.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="26943" checksum="CADAB061C49C31B8" modified="2020-12-02" version="1">MKGIFAIVCLVALGFQRLVSSAPAKKATPQPTKSPIDIHCNLHDNIRRLINQLPMATDKALVRFCSDRQPTPTIARLNSVKPNYPAGWLNGDIIQATQVLLQNVNQSIEGFQRPTLGRVPLLLKNSSSVISCFFCSLRESKNEYGRLPNSTKVVSAVNDIQIELKDLLSKIIKVGEAIKPGSRYTTKCKTCQINLTKGKRNRNQIALSLAIALERLHAALNIMKTNFFALRRACPPALVANGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I171</accession>
    <name>A0A6P8I171_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SH3 and multiple ankyrin repeat domains protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116298100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031562329.1">
        <property type="nucleotide sequence ID" value="XM_031706469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298100"/>
    <dbReference type="KEGG" id="aten:116298100"/>
    <dbReference type="InParanoid" id="A0A6P8I171"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06746">
        <property type="entry name" value="PDZ_SHANK1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="496"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="598"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562329.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="81572" checksum="22EB0C4CB6E3540A" modified="2020-12-02" version="1">MVVIMKDESKTISNHNSDQPKDFQVEVSLKLKEGLLKRVYIFDNDDKVWYAKLRVANEIGKGVKDVLNYGFYEPPCNGRSGKFLDEERTFRDYPQRKSPAELEFKYKRRVYKSLQYDGKTLQKIHTKSNLKKLYDCVSSNLVSQVTKWAEKGLDPNFQDDKTGETPLTIAVNGEERKDLILALVSGGAHLDYRSGDGLTPLHKAAFAGRPRSIKILLDLGCPPNMKDPKGLTPLYYTVLYGGDSYCCQLLLDEHAEIGVTDHQGMQEIHHACKKGLVQHLEHLIFYGADINATTASGNTPLHITALSNQEECARVLLFRGAKRDILNYANQSAYEVAAVAGNRELAEFIRTFTDGQIVKISEKPSYSTRRRKIVQKPKASSLFPRTESNASTKSDSSLPSSPRSSSGSHRSSNADTISLEENGLVNDRVQRSMSVCSTTSDSSYCSDSEILEQTANESRSRAKTNRRSRDVEHRMVRPVKIVSGAATIRKRLYANLPGSRYIAVRDYIPSMGGELEVVKGDIVEVLYVGEKGFWEGRIDNRTGWFPSSCVEELKKGDKGRPKTLFGRPSSLSSIFSKSEAQGPALPLPDDRYIQPARTVFLNRGKKGFGFQMRGANCQAPRLNFKATKEFPALQYIGEVEPRGEAESKGVKTNDFILEVNDEDVTKATHSHVVNLIKRSAKSVKLKIVTVPGXDLNGVDSIDSGYNSLAYNSLRVNNRVPPPLPQRDPSTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1U6</accession>
    <name>A0A6P8I1U6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116297632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031561753.1">
        <property type="nucleotide sequence ID" value="XM_031705893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1U6"/>
    <dbReference type="FunCoup" id="A0A6P8I1U6">
        <property type="interactions" value="1811"/>
    </dbReference>
    <dbReference type="GeneID" id="116297632"/>
    <dbReference type="KEGG" id="aten:116297632"/>
    <dbReference type="InParanoid" id="A0A6P8I1U6"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031561753.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="53334" checksum="1248A71BF240AF2B" modified="2020-12-02" version="1">MLSLRRAASIFTRRGRMVALRAGFCQARNFVQRKPSLTWSPSKSLNVTRCILPTISSSRLFSSNGLPPHTKVPLPALSPTMESGSIVSWEKAEGDELAEGDLMAQIETDKATMEFETPEEGYLAKILVPAGSKEVPIGKLLCIIVANQEDVTKFADYVPEEDKTASPKPGEAPVAEAPSSSPTPSATPTPSQPTPTPAQPASPVTRGAGDRVLASPLAKRLAQEQGIDLSGIQGSGPDGRVRAGDVKNAASATPTAAAPPAPPAMPGAAYEDIPLTNMRQVIAKRLVLSKQTIPHYYLSLDIAMDELMAIRKQLNEQYKGEFKLSVNDFIIKACALACKKVPEANSSWMGEFIRKYENVDVSVAVSTDNGLITPIVFDADKKGLSSINADVLSLADKARTNKLQPHEFQGGTITISNLGMYGIKNFSAVINPPQACILAVGGTEKRVVADSSNEKGYKLSDTMSVTLSCDHRVVDGAVGAQWLVTFKKYLENPLTMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2M0</accession>
    <name>A0A6P8I2M0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial fission regulator 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116297879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562053.1">
        <property type="nucleotide sequence ID" value="XM_031706193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2M0"/>
    <dbReference type="GeneID" id="116297879"/>
    <dbReference type="KEGG" id="aten:116297879"/>
    <dbReference type="InParanoid" id="A0A6P8I2M0"/>
    <dbReference type="OrthoDB" id="5981475at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007972">
        <property type="entry name" value="Mtfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215">
        <property type="entry name" value="PROTEIN OF UNKNOWN FUNCTION DUF729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215:SF0">
        <property type="entry name" value="WH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562053.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34155" checksum="E1115F81101A095B" modified="2020-12-02" version="1">MAIESKFTTNEIQTICAENHHQIESRFYSWRTKIDAAKECFEVEKILENRIVEIRESYDQEEEAKQKTLEEEWIALVLAKDKNLHQRIDEENTQLKNAHLQQLYLTLEALGTFSFPDTKDAVLRRNLAKMFHQVGKYCTRNNIVTEKCNLNLQNFGLPKDQPMPPPAAPPPPPPPPMIPFCTPKNLHKTPKSRQSPKTQAAPKKMGDCSTLNEQRTPLQVLNQDLLRSIKHCRTVELKSTPLKRSPGGTPAKRQRRLSENDTSDLITIALRRKFRNASVQSPNENKSPNVKSPSLEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2Q8</accession>
    <name>A0A6P8I2Q8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116295463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559135.1">
        <property type="nucleotide sequence ID" value="XM_031703275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2Q8"/>
    <dbReference type="GeneID" id="116295463"/>
    <dbReference type="KEGG" id="aten:116295463"/>
    <dbReference type="InParanoid" id="A0A6P8I2Q8"/>
    <dbReference type="OrthoDB" id="6022667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031559135.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39880" checksum="B08C02F64D218FB0" modified="2020-12-02" version="1">MDQNTIVEVKDYERNVDVYFKVLFSIDCALIVFGILANCVVLLVLFTSNKQHKSLSTFLIMYLSASDLVLRVVGLYTVVIRARKWTPLFHCKCLTFIQYTCCACVFTLLSGIAVDRYVHIIHPLKSLYFKPRKAVVIGSILVYSAAVSVSFLVSAETRDVRRRFWFQPHGPNSTRRAVEKFIPYPGESFSNSSNISMTTFDVNPERKTCVALGIGTLDGQVSITTYFTLVFVAPLFIMGYSYARIFFFLSKKARRTKISSHFARSRMKAVKMLIIVVLSFLCSWGPILVFDLLHAYNLTEEDFIHSFPRRPVLESLCYTSSIMNPVIYAFNDSSFRKSVKNIIQNFHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I390</accession>
    <name>A0A6P8I390_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563014.1">
        <property type="nucleotide sequence ID" value="XM_031707154.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I390">
        <property type="interactions" value="1700"/>
    </dbReference>
    <dbReference type="GeneID" id="116298628"/>
    <dbReference type="KEGG" id="aten:116298628"/>
    <dbReference type="InParanoid" id="A0A6P8I390"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563014.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65270" checksum="613AC681F03486E3" modified="2020-12-02" version="1">MANSNGISSFHFGKNVYLLGLNVSRRGQRAFYSGITRGKSNLEGCCKTLQDRKVSSRKINTELKPRNRKNHPNESLTSRSVVQGSFLKVFRTHQCFNSRTFVTSQRLRLQEPWMISDYEVNSLVNRCETAASVNRGIIDRYETNQLASNQPVEDRKFVVSLLHEDGEHLFGVLDGHGGDSCAQSVSHRLPDYIGLALLPPEILMELGNDVPDVREYLTMTSDSEHNGYNYMDDPICRQSLYKYFKKLKKMYVSKGYHVGSNLKQRSSRGLFTSFAEFHDVRTSFKMNALSHAFLSLDEDISAEALRFDEAGKVNEHAFAAANAGACALVAHINXTELCIANTGDCRAVLGVENENKSWSAIQLSSDHTTGNPGEVERIVSQHPPEEATTCIEYERLLSRLAPLRAFGDVRFKWDSKTQKEVYSKSNSSVRYFTEKEHLYTPPYLTAEPELTSYQLQRSDKFLVLATDGLWDMLSNEEVVHYVKAHVNKKNGAEREKTSMEITYNKQELPCEMLNSASCLIREALGGDDHVSVSTSLSIPFPDVRRYRDDMTIIVVFFDWDQLEIPSESEQDFPLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I391</accession>
    <name>A0A6P8I391_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein LOC116295583</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116295583</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559295.1">
        <property type="nucleotide sequence ID" value="XM_031703435.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I391">
        <property type="interactions" value="739"/>
    </dbReference>
    <dbReference type="GeneID" id="116295583"/>
    <dbReference type="KEGG" id="aten:116295583"/>
    <dbReference type="InParanoid" id="A0A6P8I391"/>
    <dbReference type="OrthoDB" id="1055097at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15137">
        <property type="entry name" value="7tmA_Relaxin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000393">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1051"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1126"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1167"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1223"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1272"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1306"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="18">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="18">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="18">
        <location>
            <begin position="235"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="19">
        <location>
            <begin position="335"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="16">
        <location>
            <begin position="495"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="657"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="1061"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031559295.1"/>
        </source>
    </evidence>
    <sequence length="1358" mass="153645" checksum="EF9C7BF753EA5641" modified="2020-12-02" version="1">MESPVIDPQEGFKCLRFWFFSTSTIIQLYSIKISDLSRKKLWFHNKLTKSWSFMQIPLQTQHEYKLLFKTNRQVKEIKLVVAVDDIVLSRDSCQNATSMNINCKMRTTQGDCCSFPFIYKDKCYSYCIGVDGVKPWCSLTDNYDRDGQKGFCVGGNTALKAPLAPTQRTCRIMTDSGKMCVFPFKYNNRFHSQCLTTTRKPWCATTLDLDVAINEWGFCNYTSLDQCGLCKQKTTNNQCCVFPFIYEARKYYSCTVTNFDRYWCSLTENYDRNEMFGVCSGYENHVDCRVNYGKQKPTPQWTPVRGSPSNVMWSPRLSSSDVVFNQDNVNGSIIDITSGLFEISFNVVSTKALVTFIIPDLETFTACVWMKTNDTVNQGTPFRYHGTNTTGFGLINYKNIAIRLMGKEKKSSVSANDGRWHHLCLVWTSKGGVYQMYKDGMFVIQGNDWHKDQKIPGGGSILLVGADNFVGKISGMNVWTVAMGLSEIAQRAVGCGIEGGDIVDWSTFSNRQDVVYPPTCLDVGGKGYLITLNSTKQTASDLISNVFNSPLADYSISLCFYFRYMVIGHSNASLKIYRSDLKDLDTNTTNEELVWAVSSKTSLPLWRFGTVSLSALQTFKIKVSATVGLGQGSFGLAGYFAKPGYCPSFSKCEIRGCQVQLASQSGTFTSPYFPDLYPNNIQCKWWISRPNGYVIRLKFLSFELQDSQSCEDNYVVVYDGSSSSSKILGRYCGDSFPLLLESSSNSLLIVFMSDNERSLSGFKMSYSSHIKETEDCNFIENCPPSCTCSAVLGNPPPVSIICKGLTAIPMKTPVNTIAMMISKNRLSRIEYSIYSDLQYMDLSHNYIMSVTPYSFTGLKNMTTLRLDFNFIKELQPNVFTGSSRLQKLDLGSNLLSTIKYKSLYNLQNLQVLSLRSNQISHIEKQAFGFVKNLTHLYLQNNLIEALPDGVFDSLESLKVLYLNNNKLKKVSKNTFRSLRYLEELYLDKNPIQSIDETTFGHLQNLRLLKLDRFVFCCYAYNSIKGLTCKSPSSAFSSCDNLMKNKTLQICIWILGILAFVGNIGVIIWRLIVKERNRVHSFLLTNLAISDLMMGVYLLMIAIKDLEWRGVYFKNDLQWRSSRVCQLAGALSVISSEVSVLILTTITADRYATIVFAFKFKRLKMKSAALVVTLIWIFGFVIALFPMLYSDYFYDYDGQVGFYGRSGVCLPLQLSHERFPGWEYSVAIFIGLNFIAFSFILVAYIIMFWKVRSSSRSVRSTQMNTESALARKMAFIILTDFCCWMPIIIIGVLSLLGKFPDPEKLAYVWIAVFVLPVNSSINPVLYTFSNCSLSNKKESIITSIKRRFTHAVSQGTFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4G0</accession>
    <name>A0A6P8I4G0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 7 homolog A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116298440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562778.1">
        <property type="nucleotide sequence ID" value="XM_031706918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4G0"/>
    <dbReference type="FunCoup" id="A0A6P8I4G0">
        <property type="interactions" value="1535"/>
    </dbReference>
    <dbReference type="GeneID" id="116298440"/>
    <dbReference type="KEGG" id="aten:116298440"/>
    <dbReference type="InParanoid" id="A0A6P8I4G0"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12294">
        <property type="entry name" value="RRM_Rrp7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12951">
        <property type="entry name" value="RRP7_Rrp7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034890">
        <property type="entry name" value="Rrp7A_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="43"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031562778.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30280" checksum="6A48891B9DCAEB0C" modified="2020-12-02" version="1">MASEVGGFRTLRVKLKENCSSFHVLYYKKHALREEEPMRPSDRTLFIVNIPPYCNKSALKRLFGTSCGAVQSVFLMKQPGKVKKTKASLVSPNTEIKGFKVAYVVFKKPSSLKAAMELDSTEVKCLSDEENIILTGMEKWCQEYGLQYPNPSRLQEEVDRYMATFDEEQEEAKKAEDEARGQPDEEGWITVGKGGRKPASSQIDATDLKEKKKKKKKQTQVDFYQFQQRESRREHIAQLRKKFEEDKKRIAEMKAARKFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5I5</accession>
    <name>A0A6P8I5I5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560237.1">
        <property type="nucleotide sequence ID" value="XM_031704377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5I5"/>
    <dbReference type="GeneID" id="116296365"/>
    <dbReference type="KEGG" id="aten:116296365"/>
    <dbReference type="InParanoid" id="A0A6P8I5I5"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560237.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28181" checksum="7236596CD9932F82" modified="2020-12-02" version="1">MDSQMVNRILYIIIYISTAVFCRSSPSESTNNLTEKLERKKTGIRMMALILFIITCALVFICKNFGKSSQPQEFEVIRSVSSEESSEPSIIVVNSPYDDGHYENCPLQCNVKLDKQTSTDLIPAWEETSVPIKAKPIPQIILELDTRSLETQQVEQQEKQVTAEQFGRSTCPVQALTSKITKNQLLNSRSLQPQQVEQQAKRDIKPALGKSACSVEALPTCNRITRKKLLGKVVDIMRIGWSSKETSKIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5S2</accession>
    <name>A0A6P8I5S2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lysine-specific histone demethylase 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116299403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563919.1">
        <property type="nucleotide sequence ID" value="XM_031708059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5S2"/>
    <dbReference type="FunCoup" id="A0A6P8I5S2">
        <property type="interactions" value="1322"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299403"/>
    <dbReference type="InParanoid" id="A0A6P8I5S2"/>
    <dbReference type="OrthoDB" id="5947861at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="10">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="208"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="12">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="12">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563919.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51139" checksum="5B8E104755D45E72" modified="2020-12-02" version="1">MGNTNYRPFDLGSCAELSNGCTGDGYTSRWYHISNGEHFCNACFDHMYRSHKDGYEAYAKWKFEWGGYCQREASTKTYVAETVMAYWVKCKKCGKWRSLPRTEGDLTPDLAKEWSCKSFTTSKKAKAKGPHPCDLPEDERVSGASTPGWLLSLFEPPLLKNSPATQYLKTYFPDGVGLSPVLNDDKEKIETNTNGSCSTGYLQPFYNPDIGESAFTFRPDTMEQEEEAYFPHFASTREASIIYLTLRNLILALWASGCKECLTKDKVADNIITRGLVRIPLIQEAENILRYLSIKGIVNHGIIDNIESSLSDQKLSVIVIGAGASGLSAARHLSKFGVKVTVLEARNRIGGRVSDDLSLGCCVGKGAQILTGCINNPISVLCEQLGLSMKHISGHCDLLDNKGQAADISVDKKVEFHFNSILDAIAEWRKGKTEDMPLEDRIQEMHKIFLEETQIEFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I784</accession>
    <name>A0A6P8I784_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560912.1">
        <property type="nucleotide sequence ID" value="XM_031705052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I784"/>
    <dbReference type="GeneID" id="116296931"/>
    <dbReference type="KEGG" id="aten:116296931"/>
    <dbReference type="InParanoid" id="A0A6P8I784"/>
    <dbReference type="OrthoDB" id="5958656at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560912.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49516" checksum="995C1B7A0F609AF3" modified="2020-12-02" version="1">MGELLHSAPFYQNIRKHTTKAGEILCTGIVCVACNPEKNGNKSLVKILGDVDTVNFEMESNNGEINALKTRERPETAPGCYGDHIKGRHGGKKQIKKKIAKRLPPSEGKTTPKTLVTDLPQNNENKKTKKSRKVESSKLSMKKTVVTKNNVQIGKDTARDDASKYLVVPPRSKILPLKRTTAKKTKTSYDKESALKSFQNTKNANGERNFSRERKLYHTFPGACVARSSRKYRNNSPEVIKNTNFLEMLKTSEVGIYDSKMKKVNTSSFWVEKILKQGVKEEELLPRIPQALKERKSGDGSELKTTDKITQTSSVLNAKTSSMLPRLSLNGKVEVRGGESVLIIEHEHEKLKEKDGVLHRIGFALEERQVQGSRNFPKCSIIEIADSLGEFVEMGKIKVIQRRNKRWLILVEGKTAKDFLLQNGVVIGGRHFELMELKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I818</accession>
    <name>A0A6P8I818_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C19orf47 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564183.1">
        <property type="nucleotide sequence ID" value="XM_031708323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I818"/>
    <dbReference type="GeneID" id="116299635"/>
    <dbReference type="KEGG" id="aten:116299635"/>
    <dbReference type="InParanoid" id="A0A6P8I818"/>
    <dbReference type="OrthoDB" id="10067653at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09531">
        <property type="entry name" value="SAM_CS047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039161">
        <property type="entry name" value="C19orf47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040772">
        <property type="entry name" value="C19orf47_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359:SF1">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18017">
        <property type="entry name" value="SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564183.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="45570" checksum="65BE8FB761FD2DA8" modified="2020-12-02" version="1">MTSEVPKWLSFFKEAGIPPSVASNYAIAFCDNRIQKDMLPELTKEILRDMGIMVMGDIIAILRHAKQVHAQTQKEKAVKALEIIEEQEIVSETNSPKVSSAASRMVDHWINNQRMSSGTKSPVSGTESPGNRFLKKKMTIQTKTGSKSPTASTASPDHSLLKKRLTIHASTSEYEPMAKKGATSLSERFSTKAAAASPLVTSTTKKKIVPKVQRISVQVPNDTKKLGIKQKQTALTKQKQGVSAAVAKTKTPKKQSVFDRLGDEIDIPSKPEIHTVSSTNTSAKKTQPALKPLKTSITAPKGTIKTNASAISGVELPKSVFSRLGGIAPTSSTQKVTIQPVLPSKRQQVIDVSSLSDDDNNQYEEIDYTTHSVLRPPPKKKQTVKVKPVKTVKPVKRTVGVVSQISDTTKSVFSRLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I978</accession>
    <name>A0A6P8I978_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116299300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563791.1">
        <property type="nucleotide sequence ID" value="XM_031707931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I978"/>
    <dbReference type="GeneID" id="116299300"/>
    <dbReference type="KEGG" id="aten:116299300"/>
    <dbReference type="InParanoid" id="A0A6P8I978"/>
    <dbReference type="OrthoDB" id="5982417at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563791.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21950" checksum="CE0B40C41494ADD0" modified="2020-12-02" version="1">MACKVRLNVACSSREKRFLVIAYEDWLLEDVKRCVEIVFQKLYPDEQILRVCKLQNEYHFDLPAHYTVGDTLTDAGLIFAIEQEQNPTERNSSNTFSQSPEENHTKEKKLKRKKKSKNQKKVDKRKRMSKKIATVLERWTVSSDDKVTSTTETSMNSLAEDCKLMPQVVEKVPCEDSEVDVETIEDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9B0</accession>
    <name>A0A6P8I9B0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multidrug resistance-associated protein 4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116297584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561702.1">
        <property type="nucleotide sequence ID" value="XM_031705842.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116297584"/>
    <dbReference type="InParanoid" id="A0A6P8I9B0"/>
    <dbReference type="OrthoDB" id="201048at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="146"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="13">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42947" checksum="E36EF950A1E86C6E" modified="2020-12-02" version="1">MAICGSPVYEHFVQTIEGAHIIRAFDRKDLQTNKMQRYQDNMNKAMLVVFGLKSWIVLRVDLMLALCVICVTVVSLLTSQDSTLVGFLIFYAIKLASTWNIAFAVGNLENAMTSVERVIQYTDLKRNPGYAVKTRPPQQWPENGSLSFNDVTLTYYPGAPQALKGINLNIQCGEKIXIVGRTGAGKSSIISALFRLPQVHSGSIVIDQVVIEDLNVQDSRSTIGCIPQDPFLFIGSLRFNLDPTDNCPTSQLWSVLDQVQLKSFVESIPEGLEYMVKEGGSNFSVGQRQLLCLARALLQKKKIIVLDEATANVDFVTDRLIQDTIKYQLREQTVLAIAHRLDTVLDYDRVVVIEKGKVVEXGQPRVLMIQENSMFGSLYQTKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA72</accession>
    <name>A0A6P8IA72_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116300296</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031564993.1">
        <property type="nucleotide sequence ID" value="XM_031709133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IA72"/>
    <dbReference type="FunCoup" id="A0A6P8IA72">
        <property type="interactions" value="1997"/>
    </dbReference>
    <dbReference type="GeneID" id="116300296"/>
    <dbReference type="KEGG" id="aten:116300296"/>
    <dbReference type="InParanoid" id="A0A6P8IA72"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000002">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000027">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="207"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="472"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="315"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="13">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031564993.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="57968" checksum="88C84B164B7188C0" modified="2020-12-02" version="1">MVLDLDLFRVDKGGNPDKIRENQSKRYSDATLVDQVVEADSQWRKIRFSLDNWNKLRNLCSKQIGEKMKNKEPVGDDDTLPKEILDKLESLTPDEMQKLTVSQIKNVRTLVDKGMETCNNEVTRLEKQRKEMLFEVGNLLHESVHISNDEDENPVEKTFGNSDVRKKYSHVDLALMIDGVDTDRGAAVAGGRGYFLKGPLVFLEHALIQHATRMLYEKGFVPIMTPYFMRKEVMQEVAQLSQFDEELYKVVGKGADEAGYEEKYLIATSEQPIAAYHRGEWMDKNDLPKKYAGFSSCFRQEVGAHGRDTRGIFRVHQFEKVEQFVICSPHDNISWEMFDSMVKNAEEFTQSLGIPYRVVNIVSGALNNAAAKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLQVRYGQTKKMGASTEYVHMLNATMCAVSRVICAILENFQEEEGIAIPKALHPYVPQDLHFMKFVKPAPIDEKPEAKKHKKKGKSKVANAANESGCLDTKMQSLNVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE58</accession>
    <name>A0A6P8IE58_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable assembly chaperone of rpl4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299523</name>
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    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564050.1">
        <property type="nucleotide sequence ID" value="XM_031708190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IE58"/>
    <dbReference type="GeneID" id="116299523"/>
    <dbReference type="KEGG" id="aten:116299523"/>
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    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048264">
        <property type="term" value="P:determination of ventral identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654:SF1">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564050.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42018" checksum="3645914105C10303" modified="2020-12-02" version="1">MGKERKKKKKKPTKTNKVSQNTQEDKEQCCLDMQDGSAACSDNMKGSTGSQDINENGENKTYSVEDLLQKIEECMETFNYQLAQKFCERGLELDANHLLLLETAGAVFLETGEAEKAKKCFQHAIELCPDEGHAKYMYIGQILQGQEAVEAFTKGIELMISTMNSSSKGAAKSDTVSPNDVSTAYCSLAEIYMTDECFDTEAENKCFECCQKAVEYDPSNPDAYQTMANCLMSQEKIQDAQTMLKKGLDLWLGKDDDDTDQVPMPSYESRLTSAKLLLELEDFEVAGTVLQTLLEENDEDPQVWYLLGWMYHLSGQDNTSKKISLEKAKEISVKSGCEDEQFLQHIDELLSNMNPEKNGDVMDDEDDDDEAMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE63</accession>
    <name>A0A6P8IE63_ACTTE</name>
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        <submittedName>
            <fullName evidence="11">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116299532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564065.1">
        <property type="nucleotide sequence ID" value="XM_031708205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299532"/>
    <dbReference type="KEGG" id="aten:116299532"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
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        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
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            <end position="176"/>
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            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="277"/>
        </location>
    </feature>
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            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
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            <begin position="55"/>
            <end position="317"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031564065.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40012" checksum="B2C229AE8AB764CC" modified="2020-12-02" version="1">MSRISSSADMINITQKLGDQGGSVLALVYVWQNAPALFIAVVCLYFLLIITGIILNTLVCYVMIKSKRYLKNISCFFITHMAAVDLFCRVVLIPVVVYMSLPTKAVQSPIPCKISTFXSNSCAGAIFGSLVVIAIDRYFXIVHPLSSLKRKKRPFFLGVLVWIYAVASSVXFLHTVHNVPLSDLPEAKDIERVGNPTSCDIIPGLIGGLSVTISAVMIFVIPLVTLIITYTAIFVSLRRRCQNGLVHNVAAKSKAKAARMLILVVIGFVITSGPSVVVQTLRSFKAFEDANSESLVIVLVIADILQFFSSLCNPLIYSFYSDDFKKDMIKCCFGIYVKCTPFRGQKIADTGNSRPTAPSVMTTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG47</accession>
    <name>A0A6P8IG47_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C1orf131 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565725.1">
        <property type="nucleotide sequence ID" value="XM_031709865.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300896"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28366">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 131"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28366:SF1">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565725.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27428" checksum="E5C8B8751B529474" modified="2020-12-02" version="1">MKDSISEDDIRKALKKQLEYIDKDDVPVIKPKKKKRSDKTNDAKNKKRKISKEEDKLSDAVSLTINNTDTQRPPXPPPRVIVFEEPGKSKEKNTSQSSXKLKDKNTEDSEDLDFLEIARDVKEFGMTGFSKKERRKYEQQKAQALGAKAPKGAKMPYNILIAHQKKQKQKEMKRLKLEKAMGMSTKKSKNKTKKKXNPTSSTGWWSDXSSKGLDASIGRYKKGVQVLSQSDIKKIKQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG67</accession>
    <name>A0A6P8IG67_ACTTE</name>
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        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 74B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565742.1">
        <property type="nucleotide sequence ID" value="XM_031709882.1"/>
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    <dbReference type="GeneID" id="116300913"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565742.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="59800" checksum="74184DA4F96BBCC5" modified="2020-12-02" version="1">MSDVNQNMNDDVTAAKSLNEPEVQKEEEKEIGSTTEKVPGLITEEERKTTSRESAKSRRSSKKSNRAVTSQSNLKRTTTPAGVKHADEDSDEESIHDSDYDTDLEVEEKRDEFDPTGRKAYREACAHLGIVPVSFVLEHITNEVLDIKHHGLGPSGAKAVAMALMNNTTTTKINFRDCAVGPGGGVKLSKILKENFYVTEIDISHNNIRTQGCEAFCDALNENTTLKSLSLGWNNLRDKDAVILSDMIKSNHSLKKLDLSGNGFEEEAGKIFGPAIHANDSLEVLNLSWNHLRGRGALAIGQGLRANCTLKVLDLSWNGFSDDGAAAVGESLKGNNTLVELDLNNNRISTKGALRMAEGLKSNDTLKVLRIGMNPIQNAGAHALLDAMKNNIECAMERLCLNKVVIDVETKELVDHIIGMRPFFAITCTYSNRSGNVMNDLDAMLGGNSKKKKLLELMGKLMAYVERMNYRMVDLFNQFDKDKSLSVSREEFYTGLKGIGVPMEDKDLTLFINLLDEDGDGEIDYGEFSWIKDAEEEEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGD2</accession>
    <name>A0A6P8IGD2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116300953</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031565794.1">
        <property type="nucleotide sequence ID" value="XM_031709934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGD2"/>
    <dbReference type="GeneID" id="116300953"/>
    <dbReference type="KEGG" id="aten:116300953"/>
    <dbReference type="InParanoid" id="A0A6P8IGD2"/>
    <dbReference type="OrthoDB" id="9408020at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016729">
        <property type="entry name" value="FADD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077">
        <property type="entry name" value="FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="209"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565794.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="32985" checksum="4E3373F27C150EA6" modified="2020-12-02" version="1">MGDFLKAKFFGCGPRSRNNETRGTETGRADSIAGGVQGSTVGSASENQVDATERPNNVSSSRGPTQNIPTSSEHDERQNQTRGSSGNNDQLQLPQGYRLDDIIDKDSKLYKRYLLHIAKNLTTGDDWKNLGGYLRISNNALDSISVDYGGQVKERAYQMLIKWTESSHEPTLKSLLDGLEMAGQRQLVHEISEVLRENSNQPQGGQQVTESHFLGIASDILDDWRFIGRYLGLKESVIREIEEKNIAHMKAYEMLIVWKKRNGREATLEVLQAALHDVGKEDLVKKLRQELLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGI9</accession>
    <name>A0A6P8IGI9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116300973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565815.1">
        <property type="nucleotide sequence ID" value="XM_031709955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGI9"/>
    <dbReference type="FunCoup" id="A0A6P8IGI9">
        <property type="interactions" value="1294"/>
    </dbReference>
    <dbReference type="GeneID" id="116300973"/>
    <dbReference type="KEGG" id="aten:116300973"/>
    <dbReference type="InParanoid" id="A0A6P8IGI9"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="89"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031565815.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30588" checksum="F401BB979BFECE46" modified="2020-12-02" version="1">MAASFLSRVCSSARLVGPSSTRYFTKSLQRPSLLGTSCVTKRLLTSEVTVKEDAKLVQLSEFGEYVSTMLPKYIQSAQVNYTKELEFLISPEGIIPVLTFLKDHTNAQFKSLADLTAVDVPTRPYRFEIIYNLLSLHYNSRVRVKTYTDELTAIDSISSIYPVANWYEREIWDMYGVFFSNHPDLRRILTDYGFEGHPFRKDFPISGYVEIRYDDELKRLVCEPIEMAQEFRKFDISPTWEQFPTYRTQESQPEITAGETTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH69</accession>
    <name>A0A6P8IH69_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031566121.1">
        <property type="nucleotide sequence ID" value="XM_031710261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH69"/>
    <dbReference type="FunCoup" id="A0A6P8IH69">
        <property type="interactions" value="1602"/>
    </dbReference>
    <dbReference type="GeneID" id="116301236"/>
    <dbReference type="KEGG" id="aten:116301236"/>
    <dbReference type="InParanoid" id="A0A6P8IH69"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="129"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566121.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43337" checksum="93DB9AD98539B9D3" modified="2020-12-02" version="1">MCYNMAAKMASYATRFVLHSSRDFSSLSRTQAGLSLFHRLRIQSFSSLPEDVKNKIAEGPGLGDFLSGDPPENPYRRKKGQRLRLPSWLKTEIPIGKNYSKLKKTLRELNLSTVCEEAKCPNIGECWGGGKEGTATATIMVMGDQCTRGCRFCSVKTNKKPPPLDPLEPINTAEAISQWGLDYIVITSVDRDDVPDGGASHIAETVKQIKKRSPAILVECLTPDFRGNQECIETIVHSGLDVFAHNVETVERLQLLARDPRANYEQSLDVLRHVKRVNPDTVTKTSIMLGMGETDDEIHQTFKDIRDAGVDCVTLGQYMRPTRNHLKVTEYVTPEKFKHWETVGNEMGFAYTASGPLVRSSYKAGEFFIKNLLQKKKASSSSTQENDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIJ3</accession>
    <name>A0A6P8IIJ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116301439</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566358.1">
        <property type="nucleotide sequence ID" value="XM_031710498.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301439"/>
    <dbReference type="KEGG" id="aten:116301439"/>
    <dbReference type="InParanoid" id="A0A6P8IIJ3"/>
    <dbReference type="OrthoDB" id="10036029at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13287">
        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1631"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="2092"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="2205"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="2597"/>
            <end position="2690"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="2697"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="2794"/>
            <end position="2883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2297"/>
            <end position="2322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2459"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3481"/>
            <end position="3541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3559"/>
            <end position="3594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2297"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3489"/>
            <end position="3509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566358.1"/>
        </source>
    </evidence>
    <sequence length="3594" mass="399599" checksum="746B71C7B3EB33D5" modified="2020-12-02" version="1">MGVAVSSRPKSLDNTKLKVGKKPSKKDPVNIQVLSTAFIPSDITVFSGQVIQWXWTSSENSELHHNIRQVTFSESGQPVPVPHGLCSGQLCPAGNFEVEIVAPGVYYFISEGHSSLRTTTIKVLAAPQETIKVTDQRFEPNFVEINEGESITWKWESGKGTLKKIEYCSKHGGVAFSNLNITCNTDQGNVYTYTESFEKPGLYYFTGETQDQLXIIKVLQTAREHSIKFLEHRAEPSFINGFVGDRIWVQQGLPKKNNGSSHLMVKSEDGGVLVSSRPRGKTKPDRCPSLISYCFALPGIYRVVCVNGLSTLQCIILVQTKPRDYVIRISPQGFEPELGSVKQGDRIWWMWTEEESDKCGFLIKEEERIAAVSQDFLGTRETDCKCFKSNDHLSSIGQYGLLFKTADTPGLFTYRVKAIXDWSPPERDVCSIIVQSVCKNHVVRVSDHGFQPQIVNVHPGESVTWTWLDTNISHTIQQVSHERTPVDDGFHSNFLSXSPDALSHVFTDLGVFYFTSANLSSVYGAVVVTAGNQVHKIEVTLHGIEPDPLGVRVGDIVCWRWSSDQLYSINAIESPDEIENIVKTQDIPIQRRCVAATFKTTGIYHFSCTAYLGDEDQPEIHACDSFINTIYVDPAPYSCRVNVSRDGFQPHTVTLAKHESVLWSWESIPDEQHNILLIQNPSDKDSIVPARGPAFFESGPIINRSSFFHTFDTPGSYWVTSHGTDGKSCRIDVLHEAKRVMPPTIVNGNDGGNVELFYTVFLSCVDRDVDILYTLDGSMPVENLPNSKVYDWQEGIRLSRAGLYLVRAIAIKTGWIPSEIFTSRRFWVLAEEEVDAAFEEQSIEDHLGLRQEITNWQWASCAPEISSTFVFDNVIRVDFTLSPNAQPSLIAGFQLFLNDQPYGGWLCASCPGVEVSGLTGGKRYHVVIVVFPAQQEFSPQLSNELIIKCPAVSSFGGPIISLETCDRVDALVIVWPANQDIVYNLLVNGQPMREQVSAEPDNDYCRVLFETENVDEEEKTFTIMTVIGENPQLVSNEIQFSLPLPIEIIQPTGLKSIQQDQEVNTSEDSNPSTSPSSVSKELLIVSELSVAVMPSRPDGEASFFSPETSPFQSTLDTIHEDKQLDVVSPPPRPSSTEYTDEVIREESLEQLDEQNKSGNSNEGMEDVDGGAEILEEIDDDKSLKGLHSEDGISKEQGEHTQDKDDASNQEMEGADKTVEGGADFVQEDGDDNDLKRVHPEEHDLQEQNKDDNGSQDKGACDGTMDSFAGNIYGPLEEYSNDTNLLEWECVYSSNCDYYVDGIDDDNEHTNGLANICIIECIQTRTRNISSYLDYEISSNVAKSSSRKTSGEELVFYSCEICDDLAMETPWCESYGILKEIETFEERFSVVEHSVMFWNAIVKNEMMESADDGISPVVRDVQILQGTPSVEMKKVPALDQKAHKSDKDKEKEISLENDSNNKEYMLTVQTTPELEVPDDKEETITEPYGEDKSSSVIRTQLSPELTVAVKGTSQNTVILEWEDECGIDSPVYYLMVFGDKFNSEVDSKYRYGFKSSPTPDIWPNNEATNEQHCWPIKNDVIEIRGLKPRHRYRIAVVAIPCDRNTIDSSIISRDSNTASPRSEIITFTMPGRPKAPVIYVTALRDREFTISWRPPCSYGDARVVGYRILANGKQHGELLPHDAIHHTLSDLQYGTFIHISLVAVTRHHVGDSTPSNVVTIGCPHPPPPPEIRETTTTSPDSICITWSAITTAIDPDQLKLLSSYDVFVDDVFHGSCPAGDIADIFMDSFTYTIPECIAGSEYSVKVKGHVDPQAIESSQPVHMCGCYGEPSNTLLVRCLEASCAPVLRVESMDESAINLSWDKPMVYGARHITGYILRVHGHNHDNVIDADLQSAKLPILSLGNDIEVTLLALINNTEDDARRQGQRHLELANDVGAPAQEPQDSGVESSSSVLIDKRSAKKLLSAPLTLHLWGFVRRVCDVQIKQVCCCSALVQWNLQEGDEMNQARRHDVFIEPEIFKVKCWKSEELTAQELEPIETSSLNIHLSNLTPLSRYGVVIEAFAHHPNYTEKYTGWNVSRSDKIWFDTKPRPDTLQNVRVVFSTVSSICLAWDLPSDNGSFKNIELNVYKKYNGDYDDGGDVTSLGDALFNFVINPHMTSYTIHNLDPKTMYVFTLKTLYMHIDALNDRQCSGEAVSVEACTSGVDRPRDLHVIKRTPFSIHVSWKPAVAYGDLEILYYLVHCTEKKSRTSQGVVSDSNCIRVPQGSAMGPQTEIPGLEPGVVYSIVVEAVVGLLDKDVEEGEEEDKQVNDGDEVESSIGSSESDWVSSVCSDFLSKPLAASTVAPPGVPVLFVTGISATQIHLAWNKPVALLLDSEARNRAVGQECRGRVRQISGYSLEVNGRVVTKLTSDKHNFTLKRCKPGMKYTCYLVVMTTAGDSGGKRSKKTEGLNNKQVIAVNKTELESDDETDTSFQESRSEPLEVTIPRQEHPLVVNIHYSPTSGSHVSSVSSSSSEESDEGCVVVEWKSSAALEGVGSYKVNWKSIFDEGSEDYLLPSSSSYKIYPVKQRSVYTVWLKMLRGDGSSISWGPLFCQVPGRPDPPWIWCRSVSSNRILVEWNEPEMYGVDTIRAYQVNLNGRQLGKLLSPQSRKVAVHCQPSSVYRIVVLALSTDPNLGGSDPSNLLTICTPGVKDKSLDPKQNIRIKPVWAENDSITVEWSEDNNLLIVDHYVIKWSSVLHPQSTETIVPVDHVSYTIEDCKPGTRHFIAVAAVDDQGKLVSKSQQLTVQTSAPLTAPKLRLSSSLPSSIQVEWDRSIPMGDATVHAYEIKVNDVVRSTLDSSELCFEWKDCTPCATYDFQIKVISTKEDCHSNWSEVLSVTXPGAFVPVITRAPSNHINAIHVTWYTLDLVGGATVKSYKVHYLANEEPNLTNDSIVNNPATVTHGPLNDSTNEDTLDNALPTLPYWVVLEVNLLPEGCITVFSRPIKTKVAVPPDPPQIRVNVIGLNERRALERFVCGLAQIKDRICLKLQSLQNSVVVKGSKRKEIQICKNFATMSNLEVELKNCVQNIKDLTGLVNANITWSLPHDDGDATVTGYQVLMDGEEHGTPLDKDILCTYLKLPASSKDHVISVKTLTNHPIGHSGPSNAVTICAKDFLPFVQFCYFDVHSESTGCSYEQSLTHETQNKLISTHRGSLGKPLPSPVCNVTDVVELCTKPLLTSNEKPRAVLFWTIWCHSSIKAMEVFIQFASEYSRELDFTTCCINSNQPASGHHQSLHDLLSSRGWKGQATNVQHTCGCHADNHRPSFQRSAGRDQKTGVSHVFGLVGVPTLVLCNKEGYIIWQGRCCIQDYSEYQQFMCHALSEASSQSCAXKNCTQCLLDHELNTMDINGPSSQMDSDPSDCFSYERTKRDSSLEVTGRLSRVRQKRLSLVDNNSADKTGLTGLAKGDGIALADRTSFENLHPTLVEETENLHRRLHGTHLNDTITHPKTSQSKSSQPTRPQTTQSSTRNHTKTPQNTSSSKTRKSVRFLGPERSKSAAYRTRTSVFQDRFSPLMVSTLPSLAVKSEPTLPKNRNRSATSKQKQKISVDKFSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIR3</accession>
    <name>A0A6P8IIR3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mucin-5AC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566644.1">
        <property type="nucleotide sequence ID" value="XM_031710784.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301687"/>
    <dbReference type="KEGG" id="aten:116301687"/>
    <dbReference type="InParanoid" id="A0A6P8IIR3"/>
    <dbReference type="OrthoDB" id="5984913at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028249907" evidence="6">
        <location>
            <begin position="28"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="1551"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="1715"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="1891"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1040"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1132"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1353"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1678"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1852"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1040"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1678"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1853"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566644.1"/>
        </source>
    </evidence>
    <sequence length="2021" mass="222166" checksum="8CF40B9C6FAE0CE5" modified="2020-12-02" version="1">MRFSPEITVAYFILQALLTSYIKDVSAKNVPEVKAEKDDLDGMDFLSEWSEWSRCSRTCGTGIQFRGRRCNRDRSPCLRYPRQHRTCNNQLCPLNSPNFRDVQCAKENDREVMLKGKKAKWKSIERGTTKCMLFCYPIXHRIAFYLGRAQDGTKCIDEPYSVCVAGKCTSVGCDRVLGSQKIFDRCKVCGGNGSTCKAYSGMIDREPTAEEKKEGYMKLFVIPEGATTILISEVSQNYLAIKGSSGVFVFGGDKKMSDPGTYRINATDFQYSKLPSEKSEAVMIMGPTKEDFYVMAILTDKDNPKADYEYWLPKNRPTTPPKPVFKVHTLSSSAKRRVTSKTTPRKIIFDESDFLKDRKTELYFSSSERPPRTQPMTTAGDLGESSTSTPEQHISTEYPTTTTSLLSSPRTQPMTTAGDLGESSPSTEILEHSTXPQNESTVTDPSTSASPQSTDTKPVTTKPYSSATSFQTSPGTSTFEHPIATHVPATNTRPLIQRITETVSSEYNATVQPTATEDQNITVQPTATEDQNATVQPTATEDQNITVQPTATEDQNATAQPTATEDQNITVQPTAIEVQNTTSLYIMTAHINTTSSTTTRRVNIAFEKVAHLNFTEQSNRTIELNNATQKATTTAAMEITVADITTTEQPTTIIEQTAADKQFIDSGNYSSKEQPTTEESLTTKXEINYNGTVLPTNPRVTNSTVSPTLEXTDKLGNRTSEYMTWSHWTPCSRTCGLGFKVRARLCKHXNESVCSRNETQVALCTIRQCEKIVPSWSPWRPWTECSSQCGIGLRIRVRSCRNSKVMTLIRTSCPGRRYDIEICRSFANCSSRVNMVKQSNAFITVAKSTMKTPSTSSXQEKPCQTPSLISSATPKASLSYTRATASRAVSQSAMSNHLVVDDINTKTISKMVLPVTAKMSSPTSSLTTGGIFSERGENDVLVTRGMXFSTPVETFIRMTPSTTLTASTAVPSITQSPFTSLSSTAFSLSLSTSSSSTGFLASSSSSSSSSSLSPSTLPSSTAFSSSSSSQSFLSSSSPLASASSSTSKPSPSTSLPSIPTSASASTFSSLSPSPSSPSSSSSSSLPTSSSIMSQPVSCVSCVYAATKSSTHSXASSDHPLPTRSYQMTSLEPSLSTTVIQTPKLSTSSPSMQDTIKTPSVQKPRTSSSFGGRFEAVTMSKVYTSNMTSIEPSRTSVVTTQESSTRIVQGHSNSCSRCRTSEKKQKLFCKGDYAIHVQVRNGSTTSNNKTVYHLLVQNIYKSNLPLSRDLFIRVTGVQCPCPWLQTGKEYLVIGRARRTXKXYSKIIINRRSFVEEWSGSVNSEVEVLRNRCVALGFNVSSSYLKTVNLKRTNNGENNSSVAEGPSVIPTTGKPSTSMXTLPTTIINKYSDCPPCILSVNSSIGAMYCTSEYAIRARITKYRKATNRTMFYAHLITTYKTTSKLPIEVLIRVPGEKCPCPRLVPGVEYLMIGKTKLTLNGKRRLTLSVESFYAKWRDEFEKEIDTTKTRCGLPLVTSQPDDNSTVASHQSTTIAPTVNPTIMPTTAQNNSSCPSCDQSTVAQNQQKRFCKNENVFRGRVXKSIPTATNRTLYYITMVASFKTNFEMPDKIVARLSDNSCQCSHLTVDKDYLIMGQVKLNKKGKGRVVLTKKSFVQDWNPDFIQKIDQLKAKCGLPVVNNKSGPSTEPSGTPLGKTPTPSKAVKPTTVAKVTRNEACPPCRVSANIHDFCSNDYVFRGRVLKGYRTSANRTVYHVSLTTSYKSLANLTSVILVRIPGVSCPCPHLQVGVQYVFMGWVRVKRKSVSTIALNPKNFAQKWDEGFEEELSSIRSSCKKSLVVDGPLVQSVSAKKDKTLPTTGITPHSSTASVKTSTLRTTNQAPPPTASINLTGTIEKRCAPCQTSRKRNXLYCASDYVVTVEIEKKEHNPVTQNTKYFAAVKYTFKQKDPLELMVILWVLNNDCNCPNLQLNHSYVVMVNNDFGENGIERLAMSERSFIKKWTKGLQRRISKLRNXCNTDHKGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIR8</accession>
    <name>A0A6P8IIR8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116301735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116301735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566702.1">
        <property type="nucleotide sequence ID" value="XM_031710842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIR8"/>
    <dbReference type="GeneID" id="116301735"/>
    <dbReference type="KEGG" id="aten:116301735"/>
    <dbReference type="InParanoid" id="A0A6P8IIR8"/>
    <dbReference type="OrthoDB" id="6624490at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="40"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566702.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43918" checksum="62AE1A820D61AE0F" modified="2020-12-02" version="1">MYDLQQGRSCKTCMLTFLAIIWIFKLSFCKGISSSYNITYRLAGGEFPNEGLVEVFFNGTWGRICTSSWDINDAKVVCRSLRLPPATYPIYYNTFRAVKKIKWMNRLQCSGNETSLAECPNDGWGKVSSCQKPAGVMCGHPEVHQINLTELCGEFTSPGFSRYMMTQAHYVWTIIPPIPRAMVLVYLEDTVLYRPNVLQSSSSIDVLDGAQKQLFHLDDKTLYVDPLVLYKSIGLFIKKLPVKVVYFSSFTVGVDQNSFKRIFKGIGIRGRFLITDRLFDEAPLKENWTISATSNVNGSYIIAVVSWSPFNVEGNFWITGYVVINNSTDDWQNMTYVIANNRSRSAYFGWLVGYTNYRIQVFVVLAKDDGSLMMYGSKTAAIKTPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ97</accession>
    <name>A0A6P8IJ97_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein LOC116301616</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116301616</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566563.1">
        <property type="nucleotide sequence ID" value="XM_031710703.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116301616"/>
    <dbReference type="InParanoid" id="A0A6P8IJ97"/>
    <dbReference type="OrthoDB" id="5985067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4713"/>
            <end position="4735"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="18">
        <location>
            <begin position="190"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="18">
        <location>
            <begin position="1082"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="18">
        <location>
            <begin position="2070"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="3829"/>
            <end position="4031"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="4212"/>
            <end position="4246"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="4280"/>
            <end position="4314"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="4315"/>
            <end position="4353"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="4354"/>
            <end position="4387"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="4421"/>
            <end position="4455"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="4468"/>
            <end position="4573"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="4586"/>
            <end position="4674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4669"/>
            <end position="4700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4744"/>
            <end position="4767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="4672"/>
            <end position="4698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="4744"/>
            <end position="4762"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="2140"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="4236"/>
            <end position="4245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="4304"/>
            <end position="4313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="4343"/>
            <end position="4352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="4377"/>
            <end position="4386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="4445"/>
            <end position="4454"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="21">
        <location>
            <position position="2711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031566563.1"/>
        </source>
    </evidence>
    <sequence length="4792" mass="536443" checksum="9B7D3C5DB72F80B8" modified="2020-12-02" version="1">[encoded data, 4792 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJG8</accession>
    <name>A0A6P8IJG8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116301899 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301899 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC116301899</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566928.1">
        <property type="nucleotide sequence ID" value="XM_031711068.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566929.1">
        <property type="nucleotide sequence ID" value="XM_031711069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJG8"/>
    <dbReference type="GeneID" id="116301899"/>
    <dbReference type="KEGG" id="aten:116301899"/>
    <dbReference type="OrthoDB" id="5965452at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051771">
        <property type="entry name" value="FAM167_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32289">
        <property type="entry name" value="PROTEIN FAM167A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32289:SF1">
        <property type="entry name" value="PROTEIN FAM167A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031566928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566929.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16590" checksum="413744A0FCC9FC9A" modified="2020-12-02" version="1">MNGVGLVKRHSFPLQTFTWNGVRRNPVRLNNDDIINQYKVKNAPVINSEGTTEEREARLESALVWIRKELTDMRHQDKFLTRQFIQLRTTIQRIKDENTAMLEEMEQNGGDVAANLSDLSPRKIVPRARDGRPLIRKSYSMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPD9</accession>
    <name>A0A6P8IPD9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC116303487</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031568899.1">
        <property type="nucleotide sequence ID" value="XM_031713039.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568900.1">
        <property type="nucleotide sequence ID" value="XM_031713040.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568901.1">
        <property type="nucleotide sequence ID" value="XM_031713041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPD9"/>
    <dbReference type="GeneID" id="116303487"/>
    <dbReference type="KEGG" id="aten:116303487"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031568901.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38117" checksum="8C76CB040795B5C3" modified="2020-12-02" version="1">MNDNRAPASISERLSLALVYVITFSGTTYVLSGVLFILALLCPLFWPFLLFYPVWLWYDWDTPSKGGRPFKYCFVRRWRIFNIIRDYFPITLVKTTELDPNKNYILGYHPHGMLPDGALVCFGSEAAGFGRLFPGIKPRLAMISFFRKYPIFRELVMATGIISVSRDSLEYVLDQKDKGYAVVDVIGGTREVLNTSPSSYHLVLNRRKGFAKLALETGSSLVPVFAFGQNDMFHQPRSSLPSRLGEIFTLWLRVMLKFTTLIIHDVSTFGIIPRRAPITVIVGAPIEVEKVAFPTYDEIDELHSAYVDELKELFDKHKVQYGVHKDTQLILDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPI9</accession>
    <name>A0A6P8IPI9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116302981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116302981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568278.1">
        <property type="nucleotide sequence ID" value="XM_031712418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPI9"/>
    <dbReference type="GeneID" id="116302981"/>
    <dbReference type="KEGG" id="aten:116302981"/>
    <dbReference type="InParanoid" id="A0A6P8IPI9"/>
    <dbReference type="OrthoDB" id="14788at2759"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="entry name" value="L,D-transpeptidase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="entry name" value="PGBD-like superfamily/PGBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="L,D-transpeptidase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028154517" evidence="7">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan binding-like" evidence="8">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="L,D-TPase catalytic" evidence="9">
        <location>
            <begin position="163"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031568278.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33609" checksum="6DF5844039C3A69C" modified="2020-12-02" version="1">MILVSFLALLSLSSLPKMFGNPLRMASNSYPKPFTRELKLQDPPMKGSDVMILQSLLARCPSVTSIKTTGAFDQQTQTALADFQRINHVNNSGKLDIKSATLVLDQLMYDGYKDDGKIPKGYKFKLYIPVHKDRNIETTATLYDSNYQVRYRFLVRTHGHITDTGEELNQLTTDGNTPTGLATFDLNSPEPNPVLFGPYPVVRQVKGLEGNVAIGPDEENTFIPYIRYGILLHTGEWKNWNSSRPMPNSNGCIHAHPTDLQKVDEILTKDLGVTVRSNPFGTIPYPYQPQGLLSIEQIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPN1</accession>
    <name>A0A6P8IPN1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIM domain-binding protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568827.1">
        <property type="nucleotide sequence ID" value="XM_031712967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPN1"/>
    <dbReference type="FunCoup" id="A0A6P8IPN1">
        <property type="interactions" value="1630"/>
    </dbReference>
    <dbReference type="GeneID" id="116303437"/>
    <dbReference type="KEGG" id="aten:116303437"/>
    <dbReference type="InParanoid" id="A0A6P8IPN1"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000045">
        <property type="entry name" value="LIM domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="4">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031568827.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51906" checksum="DD257661EFA1AE08" modified="2020-12-02" version="1">MSYYKNWQRERAFFGDPKFRFKKDLWLSPNRFKDYNYKNEEYSWEVLKLPGSGIVDSKTADARSWRMPSIPLPSPNYSTGRHTPYYTHPDIRIYELNRRLQQRTEESDNLWWDSFVTEFFEEDATLTLNFCQEDGPKRYTIGRTLIPRYFRSIFEGGVTELYYHLLQPKESYHNTTITLDCENTTMVTSHIKPFYTKVCTEGRLILEFTFDDIMRIRNWHFTVQQHREMVPRNLVVMQEPGMIEQVAKNVTRNGMTNFTLNYLRLCVILEPMQELMSRHKTYNMSPRDCLKSTLFQRWQRMCAPPEYQAEMMWPPTATTPGTPTKETSRPTRTRRKRKSSSTPNASTPTSSGNSTSKKKSPTAANFTLASQDVMVVGEPSLMGGEFGDEDERLITRLENVQFDASANGLREDRECNSSPMRGSPRTRIWPADTKKPKSENSSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPP0</accession>
    <name>A0A6P8IPP0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FRA10AC1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568839.1">
        <property type="nucleotide sequence ID" value="XM_031712979.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IPP0">
        <property type="interactions" value="1471"/>
    </dbReference>
    <dbReference type="GeneID" id="116303447"/>
    <dbReference type="KEGG" id="aten:116303447"/>
    <dbReference type="InParanoid" id="A0A6P8IPP0"/>
    <dbReference type="OrthoDB" id="197967at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568839.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="40590" checksum="A6A4C70D4D46C66D" modified="2020-12-02" version="1">MEYHSLNCCSKMAEMNYNEDYGSEFDEQESKRTWKDDELSGIKRKSNXTTGVTSKKFMTEEYSRVEGRNQRFHFLALDAYSRHKKMINDYLLYYGPGIEHFKRDSSRDATDLDVLRKEHRFIWNENEDSDNSWEQRLAKKYYDRLFKEYCIADLSRYKENKIALRWRIEKEVIEGKGQFVCGNKKCQENEGLKSWEVNFSYEEHGEKKNALVKLRLCPDCSFKLNYHHQRKLAKQKKKEDKEKEKREKRSRSKKKRKNKRKRDGKDEDKDDYSSSSEEEKSEEESKISSHEKSDSREERASTSKDDEPEDIWKGPAKVQVDKTREEEFEEYFQDMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQN7</accession>
    <name>A0A6P8IQN7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569391.1">
        <property type="nucleotide sequence ID" value="XM_031713531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303911"/>
    <dbReference type="KEGG" id="aten:116303911"/>
    <dbReference type="InParanoid" id="A0A6P8IQN7"/>
    <dbReference type="OrthoDB" id="10303521at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569391.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36119" checksum="F2FE32756BB35F29" modified="2020-12-02" version="1">MNYKEXLKDAFEKLYRESIQHFEEKSEDFFFNGSKLELAKEKMHDHSQEYSSGLLNRAGKKNIFTDNKTWKTTIFKRKKPPSPRINVRTLKNKRDDLKDSIDRIHFDLLFGKKNLNSEYHTTTNRTNSSYILARNIKNMKRRCHSVDERKNTFVTXIDSKITMRNKEKTLXQXRXSEDTSQEFCTHPQSLDDSGVFGENFESTRDYVNSSEMNNMNKTPKRSMSQDESGGSRFKNSKSFIQLMTEDPKATKKPGSRENKTSKFRHPACANELNPTPMYQKSAAKERRQRLQPLFSSHCGGIWKAIVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR49</accession>
    <name>A0A6P8IR49_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM136A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM136 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568753.1">
        <property type="nucleotide sequence ID" value="XM_031712893.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IR49">
        <property type="interactions" value="1241"/>
    </dbReference>
    <dbReference type="GeneID" id="116303364"/>
    <dbReference type="KEGG" id="aten:116303364"/>
    <dbReference type="InParanoid" id="A0A6P8IR49"/>
    <dbReference type="OrthoDB" id="9975421at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008560">
        <property type="entry name" value="DUF842_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21096:SF0">
        <property type="entry name" value="PROTEIN FAM136A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05811">
        <property type="entry name" value="DUF842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568753.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16543" checksum="D3D366F2CCE9BD5A" modified="2020-12-02" version="1">MAAAAEARVKQELERSLEVIEREQLRPIQGKSHICASKCCENKVASKESAQQCMTRCFQPLQEMHKYIEQELGRFQGRISRCAQECQDKVQDKLDTNTTQSQVAEYQGQVDQCIESCCSSHIIIAQQMFEKMKKVISESXQAVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRF7</accession>
    <name>A0A6P8IRF7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17 18 19 20 21 22 23 24 25" type="primary">LOC116298364</name>
    </gene>
    <organism evidence="13 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563024.1">
        <property type="nucleotide sequence ID" value="XM_031707164.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563756.1">
        <property type="nucleotide sequence ID" value="XM_031707896.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564479.1">
        <property type="nucleotide sequence ID" value="XM_031708619.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565234.1">
        <property type="nucleotide sequence ID" value="XM_031709374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565976.1">
        <property type="nucleotide sequence ID" value="XM_031710116.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566711.1">
        <property type="nucleotide sequence ID" value="XM_031710851.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567466.1">
        <property type="nucleotide sequence ID" value="XM_031711606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568215.1">
        <property type="nucleotide sequence ID" value="XM_031712355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568960.1">
        <property type="nucleotide sequence ID" value="XM_031713100.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569701.1">
        <property type="nucleotide sequence ID" value="XM_031713841.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031570429.1">
        <property type="nucleotide sequence ID" value="XM_031714569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571161.1">
        <property type="nucleotide sequence ID" value="XM_031715301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRF7"/>
    <dbReference type="GeneID" id="116298364"/>
    <dbReference type="KEGG" id="aten:116298364"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="43"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031563024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031563756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031564479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031565234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031565976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031566711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031567466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031568215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031568960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031569701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031570429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031571161.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59457" checksum="849755D29621EFC8" modified="2020-12-02" version="1">MNSTNLTLNATPNGTMPAPLPSLAQRVISAIAISALIILSISGNALVIASFYFYKKIRRSVTNCFIVSLAVSDLMVAFLSEPFWLSYEIDHWNSLPKNWNAKTFSMFWVILDITCAVASIVNLMFISIDRYFAIKSPLSHHTKMTPETSIWIILALWIYSIGAGCLFLLGWYWKFLMIFIIGFLVPLIIMVFCYVGIMVVISSKARLSNQVGTTRLDKEFKTAKSLGVVTGSFVLCWLPFFMLSLVYRYCIPCVGDIERLPALTSAVKWLHYLNSCLNPIIYAFLNPTFKVAFRSLFRKFCTNPNNFHDDMTVSASFFQSANIKRNRSTSHRNGQVGNGVLKSKGKKGFFFRRKHTLDESLQDSSSENVNKKVNENTYIEKADVLTPCATESNIKEPLCYSPRDSQPPTEDNARQERHVHYADDFKPIETVPRPLENVDCNSILSDSNNSENSEKESKETKDPSPNGYRLLSKRKNSTDELDHHLSTLTDTTEICTYHDQESDQFYFYVDGELIADKDIKTSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IST6</accession>
    <name>A0A6P8IST6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myosin heavy chain, clone 203-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116303891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569360.1">
        <property type="nucleotide sequence ID" value="XM_031713500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303891"/>
    <dbReference type="KEGG" id="aten:116303891"/>
    <dbReference type="InParanoid" id="A0A6P8IST6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097527">
        <property type="term" value="P:necroptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="423"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="131"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031569360.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="70445" checksum="1541F9207D7609FE" modified="2020-12-02" version="1">MGNQSAKEKPASPLXRSISFESVSSKDIQNAKDDEEESKKVESKKENGKKPQKGKQKRRSKDDLDLKNLSGDEIVVNIPRKKEDMKSLITKQAIEIRGHTDIIKEGKRQFVKMIGENERCLERIEERDQVIAEKDNIIQRYSEKNVNLKTQIEELRVNLSEKDKSLKDSTSEIRNLQNQLHDQEEVAKEIQIALEKAKHTETKKEKSEANGVLNEERFEVSSIRRENERLKTQLKDRESLIDEGRKVLSNLNREKDLLQKELRESERTCTDIQFTLDKINREKERDKIQLRQKEMEASAKGQALDKIESDLRKVREELKRKETTLADKERALERTERLKRQADEERRSIEKRFETERQNLQDSLTRLREEKRTCEDRLRRLEASQQAQERTVQNLEADRNRAKRSADILRKDQPWMITRDEIILTDRVLGTGAWGKVYEGNFRGMKVAVKELHEIIQSVHNKLLFDREITFATLVRHPCILQFLGVADYRSNSPLLVTELMDMSLFQLLTRDKVLEPSHVITLGQDVAYGLNYLHCFRPRPIIHRDVNPGNVMVWRQGNVWRAKLCDFGSADFESGNMSINPGNPFYSAPEVLSPRQTVKVSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU32</accession>
    <name>A0A6P8IU32_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116305058</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570756.1">
        <property type="nucleotide sequence ID" value="XM_031714896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305058"/>
    <dbReference type="KEGG" id="aten:116305058"/>
    <dbReference type="InParanoid" id="A0A6P8IU32"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018363">
        <property type="entry name" value="CD59_antigen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00983">
        <property type="entry name" value="LY6_UPAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027992146" evidence="2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="3">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031570756.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17902" checksum="AE0557D16DFD2970" modified="2020-12-02" version="1">MIWIEINLLSLLLCCQPVLALECYYCHSYYSWQDCDKHLQPDNCSSELNTCYTSHRVQTYSSGRQVHEFLRSCFHTESCTSEECNAVEDDRVTGSWCEFECCNTTFCNHVVTQWAKKRGYVMMELASDGRXGMTSAVANQWSLLSSMLFWMLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUB3</accession>
    <name>A0A6P8IUB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116305148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570851.1">
        <property type="nucleotide sequence ID" value="XM_031714991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUB3"/>
    <dbReference type="FunCoup" id="A0A6P8IUB3">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="GeneID" id="116305148"/>
    <dbReference type="KEGG" id="aten:116305148"/>
    <dbReference type="InParanoid" id="A0A6P8IUB3"/>
    <dbReference type="OrthoDB" id="10027095at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="3">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031570851.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="80287" checksum="C7151D9F99618585" modified="2020-12-02" version="1">MESDKTTRPRNLNTESNLHFELQNIESDASTETNDMNRCRKNNCTIQPGTLTAGGAGSSQKRSPFRTSLRSDTVSSLDQTFVSFRDVDSAKRHYHRRLRNLSGLSSAMGILAVIFAILDIECTRIRLKRNAESQKISNSNGVLSLTGDSLGLAGIVLKATISLLSVLTCITLYKIYMTTRNLYVVKNLYHESESFLTSSLLIKYCLETLICLLHVPPLVDNLGVRFIYKMQLLVLVRLYLVTRCVKERSQLFNNQSTNLLASVTKTDVSSRFLVKTYFLKEPFLLIFTFYTLNVFLGGYCVYIIEDDLPYLDRVWMMVVTMTTLGFGDVVPVNIFARGLVGFASVLGIFLMALFISVVHETLQLTQQEKRILAYIENAEHLRTKKTMAARCLQSCWRYRSFIKRHGNAIEIGDWFKLQRARFLQHKFFETMRQWRTVRRAWTRDDYWKKFFVIDDTAMLLTDVCRTIDNIERQLGIRQGQKGSKNSLYRNPSIYSPVPKKQDTQECDRVFEYPSISFQTPLPSPCYHPNSVQAVLVDSWKSPAEQQQQQQKKEEQEKRDKPVIQVESQSLRDPPKPTNNNLENHAPSHEDTRNKRYLLRRPDFIRKTSDISTSSDHIDRGAMPLELLQSRIDSVENSLDQIYGKVKGELRDIRDAIKTLAASTTPAPRTPLWSPAMTRDGETSRADPIFSYANIEKYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVI4</accession>
    <name>A0A6P8IVI4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305500</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571296.1">
        <property type="nucleotide sequence ID" value="XM_031715436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVI4"/>
    <dbReference type="GeneID" id="116305500"/>
    <dbReference type="KEGG" id="aten:116305500"/>
    <dbReference type="InParanoid" id="A0A6P8IVI4"/>
    <dbReference type="OrthoDB" id="5981673at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052785">
        <property type="entry name" value="Enterotoxin_cmpnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008414">
        <property type="entry name" value="HBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38443">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38443:SF2">
        <property type="entry name" value="NON-HEMOLYTIC ENTEROTOXIN LYTIC COMPONENT L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05791">
        <property type="entry name" value="Bacillus_HBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571296.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="39272" checksum="9B8F32A8BEE7C76C" modified="2020-12-02" version="1">MSSKKKGALSNAQLKNKQLDVTKASTVIQTYVQMILQQPDLKLVALPNLPAHQQTARSHGNNWNATILPLMAKTDADIIDYANKFEAFYEDLVKYAKDLNNPESRKKFVEGLKLLQNTIKKKDANVAQVVKDLSSFHTNLNTDFGNFESDVNTAAVKIEGDSGEIKSLSKQLDAISDAMDKDIGLMAGGAVTIVAGVAMIVFGAISEIPSGGMSTALIGGGVLVVSAGTVMETFGSQDYSQQIEKQKSTREKLKGIKIELVGLKTTKGQIGNFVKALQSAITAASSLQAAWGALDADLQELITALQDVNPDDGSWVLDELSRAKKDWADALDQAKKLQPDGKVPTKLYQNLQDAFKEMKPRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVN8</accession>
    <name>A0A6P8IVN8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116305309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116305309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571052.1">
        <property type="nucleotide sequence ID" value="XM_031715192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVN8"/>
    <dbReference type="GeneID" id="116305309"/>
    <dbReference type="KEGG" id="aten:116305309"/>
    <dbReference type="InParanoid" id="A0A6P8IVN8"/>
    <dbReference type="OrthoDB" id="5984348at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050949">
        <property type="entry name" value="GPCR_Fz/Smo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31787:SF3">
        <property type="entry name" value="FRIZZLED AND SMOOTHENED-LIKE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31787">
        <property type="entry name" value="G-PROTEIN-COUPLED RECEPTOR GPCR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Frizzled/Smoothened 7TM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571052.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="50884" checksum="99FCE7E165DFC62F" modified="2020-12-02" version="1">MSVNSGSMLRSATSDDETSTEKDPNNSVVLIDKLRHPALLWIVFVFFLLVVWGVSLLQAVFFLITYKEEDKPNISNQTHLPQYPCNKPLKMNHANNRCALPCEWVSFTKSQDTAQTIVDNISLTISLLGFLFILLTWISIKRLRVFPHIIPLYIQGTSSCISLLIVISNAMGRKESFCSHEFFTEASKSPTNFCVAQGLLIQYFSNVTAMWFIVYSICLLQMICSNNSFHRNRSTRIPHLISAACCCLLPWILVGIVFKEGGYGTVLNMRLCLPKSENLTYYTNAMITEIGQAVACSCLLFVVFKLYSIRNLELLQGDQAKRRKSRLDKVAIRLVCLMFAYAVITALVYIPMCIQQRNKPYLKKYLKEYFGCLLFAPSSAHCSKEKYQSVAYANTFIISYLSSALFTISTISFLAFNKQSRRLWFFWWQRLVDCCCLPEETNSADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVV9</accession>
    <name>A0A6P8IVV9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304629</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570248.1">
        <property type="nucleotide sequence ID" value="XM_031714388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304629"/>
    <dbReference type="KEGG" id="aten:116304629"/>
    <dbReference type="InParanoid" id="A0A6P8IVV9"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570248.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28141" checksum="34F5C6B46CA9B545" modified="2020-12-02" version="1">MASNNEKKIRKNEERIADLEEQLRVCLRKRKKHEDEIKALKKKVQDLEEENKELAKQLQEIKASKDRDDSVLILIRIGKTMERNMCKYVLGKCFETWRFYKFKKINTYIEELVAQPADQILAKQRLTGLNQKISWDQNLVDSLKNLNQTRIGIAHPELSSEKIQKATEVLREIGELDDELVVXLNXLKGQWXTSEEMLKKVKEGRDPGGSKVAPATGRKRGAYSRTAACGIESLSSTKRAKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVZ6</accession>
    <name>A0A6P8IVZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and SOCS box protein 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570278.1">
        <property type="nucleotide sequence ID" value="XM_031714418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVZ6"/>
    <dbReference type="GeneID" id="116304658"/>
    <dbReference type="KEGG" id="aten:116304658"/>
    <dbReference type="InParanoid" id="A0A6P8IVZ6"/>
    <dbReference type="OrthoDB" id="5950161at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031570278.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36280" checksum="3F0909A0C08C113D" modified="2020-12-02" version="1">MGQRYTLFFTAREGREEDLKWALTERKISPDLRDPETKYTALHVAASKGRPACVQLLIEAGASTNAREKDGLTPLHLAVYHGYANCVKILIEYEADVNSTSRFGSTPLHQAAYFGHLTCAQILLNAGAMVNVEEAWGQTPLYLAAQRAHSNVIQLLLQYNACVSQTEKAHYKTALHVACEAQSISCVQFLLDAGADPNVQCSSGRTPMHEVVTGEEVEALSSLLIEYGARCDIADQSDCSAIDCLEALLQRYHSTSNMEKYARYKKLLEYIWKIHGQPKTLMQMCRVSLRKYLSPNSLYIVTELDIPQCLKNYILHVVEDKGCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW58</accession>
    <name>A0A6P8IW58_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570333.1">
        <property type="nucleotide sequence ID" value="XM_031714473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW58"/>
    <dbReference type="GeneID" id="116304699"/>
    <dbReference type="KEGG" id="aten:116304699"/>
    <dbReference type="InParanoid" id="A0A6P8IW58"/>
    <dbReference type="OrthoDB" id="5988091at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031570333.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16837" checksum="EC9F2E9EA7D137DE" modified="2020-12-02" version="1">MAQDSVKVTMDTVKDKCPAFEKGKACPYNVPELKGLGKGCPEFKNGCPFKGVKDVGEFKQKLGELRDNCKGKENYDKAFELINKANGEQVAKLGHCPFHKNGCQLSEDLNGKPITNDFVDMDTIKTKCPVFSERSLLPLQPSLLERVGKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWR7</accession>
    <name>A0A6P8IWR7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 232-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571517.1">
        <property type="nucleotide sequence ID" value="XM_031715657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWR7"/>
    <dbReference type="FunCoup" id="A0A6P8IWR7">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="GeneID" id="116305690"/>
    <dbReference type="KEGG" id="aten:116305690"/>
    <dbReference type="InParanoid" id="A0A6P8IWR7"/>
    <dbReference type="OrthoDB" id="10016194at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031747">
        <property type="entry name" value="TMEM232"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28651">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28651:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15877">
        <property type="entry name" value="TMEM232"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571517.1"/>
        </source>
    </evidence>
    <sequence length="936" mass="104032" checksum="5BA3707D639BCFE7" modified="2020-12-02" version="1">MPIEKYKVEHKFGIISHSQRILLENRLENKSKTSVPPGTYSRRRRHYEITENFIAKFNDSSLDGQENLLPFATKMLARVKRRVGLREGGEGDHVSLPKAWAELSLLAQLNNKELQEESLEVLITSLNQAPLLQSHIPSLFFLAMTALHWLRKIGVNQPCLRTGELKLIKMGHVVFVRLYYFYLNNSLTQGYMKEKQALLIYLAGLSEQQYVYRSFPGSLLALRFMNEVGYLICKGVPVPQEQCATSPTTIEPSRSFPGGSNSGEIPHVNSKASKESFIGYPYMEKIAEEEQHSHSPTAMRTHTSVESIHDVSATLWHILDVWRCTMHKGIGLKQALDGLSVCGTGMAAESWLDVSCAFSILAHTCSTNLSALQTFQSLAAGAFPRPAALAEIHARHLNLCEHCHSGFIGDPSAHALHQEEEIINDGLPAGSDYLSVGQTPSFVRGLREFANLSHIEKNERKQPPESIETESLRSRDEKHESSSEASFADVSSIESEGQTRRKGGKMPRRASSKQFRSSYKSFQFENGSSSSEEEETRKPKEKVTKRNSSKERLGTGVRFQTEEPGTSDTEVKPHSGTPKPGEPLERELTKGSLYSGQTAGSTVTIPLVDDDKSEGPSITKTGTSLMNDMIGAYGWPWELVYLYTEAMTSVCLHGNSSLVQKVALLGSEAYKKPKVLGKKGTVQASGLGLADMLKFKLPETKVSANKDWSWRIRFAAVQGLVRVSRHSYGDSIKDGMCSTAWNLLMRHHSTEKDMRVLEALKLAQVEVEMDKGSRAYPSMLISHIAAGLASTMLPQLPPIIDLPEMTLRPKSRVAKVTGSPPKRAPTRPSLRQEILLATASYEPPEGYGARMNKELMTVIKDQWRKQLHIDEEEEEAEKRKREGEKILREEMDGKADGKMDGKKDGTQSSIKEENLDGVDDGCGMLSSVSGRLSIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWU2</accession>
    <name>A0A6P8IWU2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ras GTPase-activating protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116304855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570503.1">
        <property type="nucleotide sequence ID" value="XM_031714643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWU2"/>
    <dbReference type="FunCoup" id="A0A6P8IWU2">
        <property type="interactions" value="2349"/>
    </dbReference>
    <dbReference type="GeneID" id="116304855"/>
    <dbReference type="KEGG" id="aten:116304855"/>
    <dbReference type="InParanoid" id="A0A6P8IWU2"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13260">
        <property type="entry name" value="PH_RASA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF146">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="223"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="356"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="455"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="11">
        <location>
            <begin position="623"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031570503.1"/>
        </source>
    </evidence>
    <sequence length="916" mass="103939" checksum="FC9CC9ACE8ED3CF4" modified="2020-12-02" version="1">MADRDRNGSLGSDGVLGGENEADGHFEDEIGLDILEDDEQNIELASSAPPEDQWYHGKLDRMKCEERLNADGREGAYLVRQSDRKPDTYSLSYLSKNGVCHFRITAVCSEYYIGGRQFDSLSDLIGYYTRWSCLLKDEQLANPVPPPEPVTGKRRVVAKYTYNKTPDTDEISFCKGDVFIVDNVIDNDWLWVAAQKNKERGLAPAALLQDAEPDLDPHAGKPWYFGDITKDGAQELLMRDGAVGSFLIRPSDKSPGDYSLSLRYQQGVTRFLIRRQGSQYLMGGRLFDSIDDVVKRYKHEHIVEGLSLKEPVSRPQAWNIPHRPMTPNRGSDSIDGFTFMPQAGSVGPAIMYTSQQASKRGYLVMKGHRNKWKRMYFVLDGQEQKLSFYENEKRTKPKSLLDLTLSTVYVVHENFFGRPNCFQVVVRALNESRMTYLCADTQDQANEWMDAIKKFCGKAKTADVGDLDVKQLRSLELNVIEAHKLPPNKVSHVYSIISLNEVKTCRTRTFEGQKPIWNEDFKFNDLPADVTSVTISLYNRSWHSRDILIGSCTQTLQKLPKGQTKDDWYPLIAHGKAEVGNLRMRIKFTHEIIMPVGEYDNLKEILLDKDLFAVTALGQVCKDRVSLASSLLKIFRHEKQELFLLKTMNAKEIEKQDEQGTLFRGTSLATTLMDQYMKMVAIPYLQQTIKDVIVKIMECKQSCELNPAKMEKGADTVINLKQLLEFLFEAIEAIFNSADNCPVSLQYLFGCLQQNVRDKWTDNQTVQTRVVSGFLFLRLFCPAIMNPKLCNLMTDIPSATAARTLTLVAKCLQKLANLVDFGAKESCMTPVNPFMQKNRDKVIAFINEISSVNDCPDTHEQVSSDPARDLASLQDICVVYKSDLKQLSTTQPCLKKLVAVTEALQQREQQFIRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IY70</accession>
    <name>A0A6P8IY70_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endothelin-converting enzyme homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031570908.1">
        <property type="nucleotide sequence ID" value="XM_031715048.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116305194"/>
    <dbReference type="InParanoid" id="A0A6P8IY70"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF232">
        <property type="entry name" value="NEPRILYSIN METALLOPEPTIDASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028185638" evidence="8">
        <location>
            <begin position="26"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="252"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="691"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="12">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031570908.1"/>
        </source>
    </evidence>
    <sequence length="905" mass="103273" checksum="40E388F2CFD185C1" modified="2020-12-02" version="1">MKSFPNERRWILIYLICCALNCVYSRQVLTMKXTPMDDSTSQNSIKVVGTVPGTAFKQQPAITTTGVTELKSVDAQVEDSPPVKVVQQTEQNPIQGQTQQVATGGQAQEQEETASKSAQTVATTLTVSKDEKNKSSEEVAKEKPATAKPEDKKQEEEKNAGTENPATQKPDTQKPDTQKPKNEKQEAKKPEPEKPATEKPETEKPKEAPTTAQEQKVETLMSKVSGRKICQSPHCHRVAKSIKEALNESVDPCDNFYEYACGNWVKEHKIPKFHSQYSRISELSENNEKILLDSLKTDQDTDNENLRKIKLFFRSCMDLKTIDKSGNNPLVEYIKSLGSWSFDKEWDSKSWDFYKTLGKMHRGYPAEVFFTVDVHTDPTKQHSRANYIILIDQATLNLPQIVYFTSPKIIRMVSKYMSDIIGMSGVDEKTAEEKVGEIMKFEAKLATISVPKIAKKYVRIRVGKLVKAIPEFPWMEHLRTIFWPKPVNPDTHAIVLANDYLPNLFELLRKTDKSVLSNYMVWRLVKDVVPLLSKDFRHEHLDLKKKLLGVKHEKPREKKCFGYTNNLLGPLMGALFIKNAFSPESKHKVESMMEGIIKAFKNNIENVDWVDNHTVAAVEEKADEAVYKVGYPDYLWDNKKFNERYDKLNITEGAWFKNVLETDKFASLQTYQKLDTVSDKHQWITVPHLVNAFYVITKNEIVVPSGILQPPFFYPDEIPRSLSYGAIGHVLGHELTHGFDTTGRKYDKNGEEIDFSHPGKVKTWSPSSIKMFEKRAKCLVDQFSKFVVLQKFHLSGYKTLGENIADGGGVKLAYHAFRDFLEKHGEEEILPILDIPHEQLFFLGYAQKECVRTSPAAEFMAVMDDVHPPSKYRVIGTLSNMEEFSKVYKCKKGDKMNPEKKCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ11</accession>
    <name>A0A6P8IZ11_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571183.1">
        <property type="nucleotide sequence ID" value="XM_031715323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ11"/>
    <dbReference type="GeneID" id="116305430"/>
    <dbReference type="KEGG" id="aten:116305430"/>
    <dbReference type="InParanoid" id="A0A6P8IZ11"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571183.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="72082" checksum="617DC7E43F06FBAD" modified="2020-12-02" version="1">MLGRVLKRYQQTWRVLLFVVIFSSLLGFVHPRRKPHIIMIVADDLGWDDVSFHGSPQIPTPYIDHLANNGVILNNYYVSPMCTPSRASIMSGKYPIHLGMQHFVIYAAQPYGLPLDEITLPMYLKTQGYRTAGVGKWHLGFFTKEYTPVYRGFDSFYGFWNAKTDYWNHTSDENNFWGIDLRDNMEPVSTESGVYGTELFTREAVKVIDNHDKSQPLFLYLAHQAAHSANPNEPLQAPQDKINRFTDTIDQLQRRIYAAMVTSLDQSVGDIYSALSRNKMLKDSVIIFTTDNGGAPHGFNWNMGSNYPLRGGKDMLWEGGVKGTAFVYSDLIQHKGRVSHDLIDITDWVPTIYHLAGGNAELLHGYLDGKNVWETISRRGKLSPRDEILHNIDPWRKFEAIRKGRYKLVVGMDDTYQVGWHPRYKGRDISLLRQPDTLPGAILRCGVWDKSKMCDSSKGKACLFDMKKDPCEYHDISSDLPHIVQELKERLDFYRKSSRPVWYPGIDKNANPARFGGFWGSWKELKDNSSLINAWNSVWKLANIQRNAAQRKVKGVSSAAHGNTGTSANGIIDLAWEQSKPLADSMEDNGATLTWTPNKPIEIHSSEKPKDHVDRFYYHRFSDSRNEYSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J049</accession>
    <name>A0A6P8J049_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031573186.1">
        <property type="nucleotide sequence ID" value="XM_031717326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307176"/>
    <dbReference type="KEGG" id="aten:116307176"/>
    <dbReference type="InParanoid" id="A0A6P8J049"/>
    <dbReference type="OrthoDB" id="10256774at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="91"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573186.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="33531" checksum="C930889E8F832CFF" modified="2020-12-02" version="1">MEQCGEETRIIVQEEEKIDEGLPTNHDTEHLECRRLLELYSRLSEDERKMFLKTMPKANYKLQRQLKDTKFPGLPEMEGEEEDEFTRFTLHPERNHKPNSYAQMHFRLAESQFFRLEDDNKNYRVTKVEYIVNPFLEKRFREEQEKLRSTRGEENCQPVLAFHGTSEESILSIVKTGFRMPGNPGYKQANDSGWYGRGIYLSEYPSYAREYMKRGGVSSKLLLCQVLVGKXFHCEERIDGEALKDGFDSHLSPAMHQLIIFNERHILPSYVVHFEKSEGDFRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0N8</accession>
    <name>A0A6P8J0N8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Smu-1 suppressor of mec-8 and unc-52 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116307026</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the spliceosome B complex. Interacts with IK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573029.1">
        <property type="nucleotide sequence ID" value="XM_031717169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0N8"/>
    <dbReference type="FunCoup" id="A0A6P8J0N8">
        <property type="interactions" value="3075"/>
    </dbReference>
    <dbReference type="GeneID" id="116307026"/>
    <dbReference type="KEGG" id="aten:116307026"/>
    <dbReference type="InParanoid" id="A0A6P8J0N8"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000082">
        <property type="entry name" value="WD40 repeat-containing protein SMU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000289">
        <property type="entry name" value="WD40 repeat-containing protein SMU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="14">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031573029.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="57537" checksum="4D8374781783515F" modified="2020-12-02" version="1">MALEVESADVIRLIQQFLKENSLQRTLATLQEETGVTLNTVDSVESFITEINSGHWDTVLTAIQSLKLPDKTLIDLYEQIVLELIELRELGAARSLLRQTDPMIMLKAQQADRYLHLENMLAKSYFDSREAYPEGGSKEKRRAAIAQALSGEVSVVPPSRLMALLGQALKWQQYQGLLPPGTTIDLFRGKAAVRDEEEEKYPTQLNKIIKFGSKSHPECAKFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQENFMLMEQSVLCLCFSRDSEMLATGGQDGKIKVWKLQTGQCLRRFERAHAKGVTCVMFSRDASQLLSGSFDMTIRMHGLKSGKTLKEFRSHTSFVNDVIFTSDAHNIISASSDGTVKIWNIKSTECLHTFKPSVGSTTTDITVNSVTLFPKNVEQFVVCNRSNTVVIMNMQGQIVRSFTSGKREGGDFVSCILSPRGEWMYCVGEDMVLYCFSTTTGKLEQSVQVHEKDVIGIAHHPHQNLLATYSEDGQLKLWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J110</accession>
    <name>A0A6P8J110_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573174.1">
        <property type="nucleotide sequence ID" value="XM_031717314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J110"/>
    <dbReference type="FunCoup" id="A0A6P8J110">
        <property type="interactions" value="1752"/>
    </dbReference>
    <dbReference type="GeneID" id="116307163"/>
    <dbReference type="KEGG" id="aten:116307163"/>
    <dbReference type="InParanoid" id="A0A6P8J110"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000008">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031573174.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12758" checksum="C254A4BA3C80B10A" modified="2020-12-02" version="1">MAAVADPRLRQLKIKTGVLKRLSKEKTMYEKEVVDQGQKVEKMKAEGKDSHDVNKQIEVLEESKIMIPDCKRRIKTAYEDLKNLVSESEKDLDGSEELKQAKAILGETVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J120</accession>
    <name>A0A6P8J120_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-uridine preferring nucleoside hydrolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573606.1">
        <property type="nucleotide sequence ID" value="XM_031717746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J120"/>
    <dbReference type="GeneID" id="116307478"/>
    <dbReference type="KEGG" id="aten:116307478"/>
    <dbReference type="InParanoid" id="A0A6P8J120"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02649">
        <property type="entry name" value="nuc_hydro_CeIAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573606.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40040" checksum="4AB90015A39A948C" modified="2020-12-02" version="1">MICLAYPLLCHDGVRAVNFSQSYKSCTSPFRNVTSKKRLFIFNLEKIQPKMASASRLTKTKKLIIDCDAGIDDAQAIILALSLDVEVLAITCVAGNIGVDQVVKNVLKVLDTCGRTDIPVYKGADRPLLGQAFELPNYHGKDGLGDATDAKGPDMDLVKSTHAVAAILNLVNENPGEVTIAALAPLTNLALACRMDDDFSKKIKAIELMGGNKHGIGNHFISAEFNFGADPEAAFVVLDQFECPINIISWEFCLENPIEWEFFNNYIGLPTPKSRFLKAISTKIADYEAGGPWLTCDPFAVAVALCPDIVLEDKMVHATIELSGKVTKGMMVIDWRGKLEKKHNVRLIEKVNLDRFKALLLRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1X9</accession>
    <name>A0A6P8J1X9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116307419</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031573534.1">
        <property type="nucleotide sequence ID" value="XM_031717674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1X9"/>
    <dbReference type="FunCoup" id="A0A6P8J1X9">
        <property type="interactions" value="2092"/>
    </dbReference>
    <dbReference type="GeneID" id="116307419"/>
    <dbReference type="KEGG" id="aten:116307419"/>
    <dbReference type="InParanoid" id="A0A6P8J1X9"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14535">
        <property type="entry name" value="PTP-MTM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000038">
        <property type="entry name" value="Myotubularin 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="13">
        <location>
            <begin position="163"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="9">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="376"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031573534.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="70255" checksum="87020772B7F711F9" modified="2020-12-02" version="1">METKKLQSQLNKAEGLALSTMADDDGKDSSHSGELPLIKGEKAQASAKDVTYLCPFSGPVRGSLFVTNYKLFFKADDDPPFFVEVPLCSIFRIEKIGGTTSRGENAYGLEISCKDMRNLRFAHKQENHSRRLVYDKLTNYAFPTSSGKPFFAFSLKEEYEVNGWEVFDVEAEFERLGLPTDCWHVTKINEKYEICDTYPAILGVPSSVTDEDIKKVAMFRSRGRLPVLSWLHPNNNASITRASQPTAGVMNRTRNKDDEKYFQAILDANPQCHKLLIMDARPRINALANQAKGGGYETEENYQNTEVIFLDIANIHVMRESLRKLKDICFPTIDDAHWLTNLENTHWLDYIKVILAGAVRIADAVDRCRTSVVVHCSDGWDRTSQLTALAMLLLDPYYRTISGFEVLIEKEWLSFGHKFTQRYGHGDKNYTDDQRSPVFLQFIDCVWQVTKQFPCAFEFNEIFLITILDHLYSCMFGTFLCNSEIQREKEDLKSKTVSLWSYINSNNMEFKNPLYAPYLHQHVLFPVPSMRRLELWTHYYIRWNPRMQAQESEELRNRELFCLCEQLRNKCEELQHEIDSRMTVEVPSNPDAVSIHSTNSNPNWTSSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4R3</accession>
    <name>A0A6P8J4R3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain-containing protein 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574634.1">
        <property type="nucleotide sequence ID" value="XM_031718774.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J4R3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="116308368"/>
    <dbReference type="KEGG" id="aten:116308368"/>
    <dbReference type="InParanoid" id="A0A6P8J4R3"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18494">
        <property type="entry name" value="BACK_BTBD19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18294">
        <property type="entry name" value="BTB_POZ_BTBD19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042846">
        <property type="entry name" value="BTBD19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574634.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33683" checksum="D7F5830BDC7983EF" modified="2020-12-02" version="1">MXYSLAKTMAEDRTIPGCPWAFADDMRRMIDKKEYSDVKFIVGTNRRVIYANKCILAARCDVFRAMLSDERSTHVRTKNVEPDVPLVLADISPEVFMSILEFLYTNTCTLTSKNVMDIMGSAIEYGLEQLQKICEQYIGETLSVNTAAEALQTAVTYNQEELQDRCIEFIEAQTVEVFKTKGFHELSEESLTLLLASDKLRMDELDLIGAVREWATVNAVVSGKXVAEVAHPVIHHIRFGLLSPEELGQVEQDNEKDSLIPVRQLSDAWKFHALIKSPTHSAAMQKPKTRIGTRQRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4X8</accession>
    <name>A0A6P8J4X8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ribosomal protein S6 kinase-related protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116306612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572555.1">
        <property type="nucleotide sequence ID" value="XM_031716695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4X8"/>
    <dbReference type="FunCoup" id="A0A6P8J4X8">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="GeneID" id="116306612"/>
    <dbReference type="KEGG" id="aten:116306612"/>
    <dbReference type="InParanoid" id="A0A6P8J4X8"/>
    <dbReference type="OrthoDB" id="3205605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="90"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031572555.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51601" checksum="21A94C54D718BE71" modified="2020-12-02" version="1">MGNTHARKPDDTSKRRRRPNSIAVDKPIETLTTESSGKRELRRNSSQNSFRRRYTESGNYAYKTPWPAPMSEVVFWPEYESKPPVRFTDFELVANIGKGAFGHVLQVRKRNTGEVFAMKILNKAEIIKENAIQQCKDEVNIQTKIKNFPFLVKTWHTWQTKHNLFIVSDFVDGSDLFTLWIQEKTLKEDLVRQYIAELALTLDFLHKCGVVYRDLKLENVLLDKQGHIKIIDFGLSKLMNTEDMSNTICGTLQYMAPETLRGEKYNYLVDWWALGIVMYVLLVGKYPYAVSKDHQSQSKVVQLAEFEFPENLSSEAVDLMTQLLQKKPKNRLHSLESLQRHSFFKKFSFDDVLNKKTQPVDEEILQKLTKRSTASRTAFPRKVEPRKDKKPRPLSWASPGNFTIHDKVEMDWLVADLESLSNVESVTTTSVTTKTPLTPVGELCTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Y9</accession>
    <name>A0A6P8J4Y9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Decapping nuclease</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031575136.1">
        <property type="nucleotide sequence ID" value="XM_031719276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4Y9"/>
    <dbReference type="GeneID" id="116308787"/>
    <dbReference type="KEGG" id="aten:116308787"/>
    <dbReference type="InParanoid" id="A0A6P8J4Y9"/>
    <dbReference type="OrthoDB" id="5987680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="28"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575136.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43651" checksum="8E6B5987B3D5366D" modified="2020-12-02" version="1">MAAGNQNQSFVQNTELDTDFSSWSTDIIGSYSIDAQGNFYNNDQRELCSLIPNYDSKYGSDLTAGFDPSVKEHHYSRPLDSLLYWIVLNKDTISRTGNGPGKQRLDADFVFTVGTMRKLLATVFNTGSYKQPWKMYAIKYNGTIYIRNGENTSEERRPEEERKDVYMGLKFEELISKLDPCESQGKPADRKVDGSRQGFYSVRRGKFGGRHLVLTRAQVDFAENGKYVECKLCPNYTGRDEWKFPMYKLRNWWYHMCAADMKQVIYGIRDGPTLKEVSRITPDEIPLEVNNPKMSCKTKTQLALTSWNPMACIGFVDEFLQWLKGVVVEDSYGMDGGRAVQYVLEWGKSSPSIGYSREEVRMSNFVLPDWYIREMSAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Z4</accession>
    <name>A0A6P8J4Z4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KAT8 regulatory NSL complex subunit 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574729.1">
        <property type="nucleotide sequence ID" value="XM_031718869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4Z4"/>
    <dbReference type="GeneID" id="116308447"/>
    <dbReference type="KEGG" id="aten:116308447"/>
    <dbReference type="InParanoid" id="A0A6P8J4Z4"/>
    <dbReference type="OrthoDB" id="5970609at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056519">
        <property type="entry name" value="KANSL3_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF16">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23154">
        <property type="entry name" value="KANSL3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANSL3 helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574729.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39530" checksum="7E71D086B3EA929D" modified="2020-12-02" version="1">MANMAAFANPSRAVFVRNIQSLVEIILTDHAYTKPWSAHPEASKAKPMKTLFLPKDDEKALCKKVEDEEIDVCEVEPSNNSTIIYDTTKAKTVMCECEKHVTTVTSKRTPDTWEELICRTGWGPKQNSLFDKVIKVLSTLRLARLAFEQTPNEPVKRRIATDKATKRFRQILSTIEWDPKLTAWLHTTLVDGLSIPLLACYLDVLQTLRAKAPTLVDRIVSNHTSQRRGPAANAEALSLLLKRPWDPSHGLVTQHKTRKLPGSPLLLIVPSGPTTNTGSGTSSKRTRFWHNQLSVLGKVVPVTMHTSNGGSGVTISQCLDHIIGAVRTKVLELRSHFPNRPIILIGWSIGALVSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5P1</accession>
    <name>A0A6P8J5P1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308688 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575024.1">
        <property type="nucleotide sequence ID" value="XM_031719164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5P1"/>
    <dbReference type="GeneID" id="116308688"/>
    <dbReference type="KEGG" id="aten:116308688"/>
    <dbReference type="InParanoid" id="A0A6P8J5P1"/>
    <dbReference type="OrthoDB" id="5990608at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027753869" evidence="2">
        <location>
            <begin position="29"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575024.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="62020" checksum="DD940682FCB0F945" modified="2020-12-02" version="1">MPFICQNCSKMGALLLLSLTILITRAHSNPWIFQEIKPLTEADAVKKSTIPDAPVKDADPATPTIHIKQDIRDDILGKNKSSTKFKEGVKKLLDFLEAGPEAVGDAPDKETTSPSVLNSHEDAAKNNSKNDNQLLKQNNQSLSYKQEKQSGSSQMNGVNSKDLNSFATGGNLDNHEKEANSNFVNQQREPPAIPMRSEINGNGVVPIQAPESLDKHLNSVAAGDHLSSFNKDSHDDKPLKESNFVTQQKEPPAIAMRSKINGNGMLPIHATMSLLRDGIADKDPSVLVTAPRMGSNLVAKSQIPYTTTPYQSTQLLQNNAIVRSRNPTPANLQHLKYNPYSALYQRSSFPHYYGNYGLTHPNTMATPAYRYPYNQRRMLPLKANSFNTALRSNARLPFYRTATPAYNPQLQLHYAKTFVPRRRLAMIPQRASMSSFLSRRSNIPTFRNFQISHPYHVNPVLPKWNLLGRNTIFQPASRPRGLKYRRLAVSDRGHSYNGLSSPRDKVTQKTPLPLPLASIMTAARIVVPAQPHTLNGAFKSNVETLPSGDPGEEKVARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6I9</accession>
    <name>A0A6P8J6I9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Arginine kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575374.1">
        <property type="nucleotide sequence ID" value="XM_031719514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6I9"/>
    <dbReference type="GeneID" id="116308988"/>
    <dbReference type="KEGG" id="aten:116308988"/>
    <dbReference type="InParanoid" id="A0A6P8J6I9"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07931">
        <property type="entry name" value="eukaryotic_phosphagen_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000006">
        <property type="entry name" value="Arginine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF38">
        <property type="entry name" value="ARGININE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="11">
        <location>
            <begin position="134"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="303"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="334"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031575374.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47576" checksum="3B445CD283D0A5A5" modified="2020-12-02" version="1">MSDKTPDPYFDLIMDEDLANNEWPRGLDEIKEKGTRCIAISSISKEDFEANKHIKTKSGGWTLARAINTGVVNPTSFLGCHAGDLESYQVFGEILFDKVIAKYHGGYDVKTGNHVTDMDSSKITEDLSPEAKKKIISTRIRVARNISTFPLNPGGTKETRLAIADLMEKVFAGLEGDLAGTFYRHTTMTPEQQQQLIDDHFLFRGKDKMQAASGYHEHWPHGRGIFVSNTKEFLLWINEGDHLRIISMEKGGDVKRVFDRLSRGIAAIEAGLKKELGIDDVFMHTPSHGCITCCPTNLGTAMRGSVHILVPKLIKSMGFEAIDKFARERNCQARGSTGEHSEVIDRIDISNWRRLGYSEWSLVQDMIKCVNELSKMEDEAPEGSDAEKEKEKEEEKEEEKEKSDQNANTNDAKNGEAKAKSCSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6N5</accession>
    <name>A0A6P8J6N5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Allatostatin-A receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573543.1">
        <property type="nucleotide sequence ID" value="XM_031717683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6N5"/>
    <dbReference type="GeneID" id="116307428"/>
    <dbReference type="KEGG" id="aten:116307428"/>
    <dbReference type="InParanoid" id="A0A6P8J6N5"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573543.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36704" checksum="3738178F947FCF7B" modified="2020-12-02" version="1">MDPSNTTYSSLARELANRSLMAVVLESTIAFLMLFLGFSGNVLVCLAVCRNPALRTSCNYLIVSLAITDVAMMLCCSPFSLVVVITGRMIFPDLLCQAQAYMILAFASISLVTLTQATIYRYLKVVHPARCFNIQTVRLVITLTWILFLFFPSVYFFSEKAMFYPGELYCFIRIEEMSKVLVLTATLIFSVIPLSIITFCYSMVFAKVRKHKQNTRKNIHASTRRPQASHFSPEEARVTMILVAVVIGFVICWTPVFCVRLLSFYKVSLPRKVHLMSTAFAAMSSCVNPFIYGVLNRDFKNEFKKILARFSCRSVVVAPACDQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JA99</accession>
    <name>A0A6P8JA99_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116308402</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116308402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031574673.1">
        <property type="nucleotide sequence ID" value="XM_031718813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308402"/>
    <dbReference type="KEGG" id="aten:116308402"/>
    <dbReference type="InParanoid" id="A0A6P8JA99"/>
    <dbReference type="OrthoDB" id="5978071at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039684">
        <property type="entry name" value="FANCG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15254:SF2">
        <property type="entry name" value="FANCONI ANEMIA GROUP G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15254">
        <property type="entry name" value="FANCONI ANEMIA GROUP G PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031574673.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62455" checksum="13D69220FA59FE67" modified="2020-12-02" version="1">MARHEVDAGLNLLNIMGDSLSDXEISSSLSHQETILIDTSFIKQVFPLCLLPLPRELGIKPIKAAVTFLSSLCYKYYKHDIAKALGILDATGGTECSYISSCVNYLKGLTYFENNDTDKALQYLNLSVTDIPLVDERYKAAGLCMLGCCLSRKGKHHTAIAKFKESLTYDFSHLDSLFYIAQEYQALGQEEAEIQCLKYLCEALVLRCNQDTNPQSLLQGHFIPFVDKINGRTVNLRYATYWLGKRCLALDRFQEAADALLEVLKEARRPCQPQVASPYALPSVLHLYRDCAFALLKSGREKDCVTMCDNAMEEAQDGEYEIDLWNSDDIPSKKRIRNTNQSSQQTRKFRSCCLEILLCKAAALSQMTQSLQSLECLQRVFVALENCISSLGDEEDSNGNRELKRRKLESDYSRGVITADTQTTKCYKNKEIELERKKLHQIKSQAHLIRASVMLQLLDQEKEGLEELHQSSLCDPDNTVALFKYCTLLMKLGSRNVAASDWMKFRGLDLRTKKPFLDFQNRSNGGTDALSFYDVTQKELKSMDDLCLKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCB4</accession>
    <name>A0A6P8JCB4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116308874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031575243.1">
        <property type="nucleotide sequence ID" value="XM_031719383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308874"/>
    <dbReference type="KEGG" id="aten:116308874"/>
    <dbReference type="InParanoid" id="A0A6P8JCB4"/>
    <dbReference type="OrthoDB" id="5956703at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="286"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575243.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46129" checksum="EC9A0C95A87C9704" modified="2020-12-02" version="1">MADDKNKRCWHWSCAEKSQGTDFNRDFICSAHWRKGECQSLDDLPDLACEPTFIDKKVTKKTXPVRKIESAKRSLTEQQSEGSKKKRRRVLSYNSCIESSNVDLLQNEIDNLKEKLRGKTNEVNQLCDLVKTLEVQNETYQSQLKQFAHKTEKSTFSYKCLKKNPKQFFYMTGLSVDFDCLFACVEPYISAMIYPDCKTHQQRKLTKKTELMCFMTVCRHTLHLGIVGFMTNTSDLTQSRIFTAWAVFLSTLFDQLDLSPCPGEVISFLPIDFYASGFKDTVLLGDCTENWIASPENYDISSTTFGSYKNHDTGKTXIWITPYGSLLMCTDIYLGAITDNDLTEDCGVLDKVKDKGAAVLTDKGFGIEDLCHAKGLSHNRPPMKFSVKKRTLMWPPYAYIMKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCI6</accession>
    <name>A0A6P8JCI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Coiled-coil domain-containing protein 18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116308935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575313.1">
        <property type="nucleotide sequence ID" value="XM_031719453.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575314.1">
        <property type="nucleotide sequence ID" value="XM_031719454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCI6"/>
    <dbReference type="GeneID" id="116308935"/>
    <dbReference type="KEGG" id="aten:116308935"/>
    <dbReference type="OrthoDB" id="5975666at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575314.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="44541" checksum="E0DCCDE11CA4BB00" modified="2020-12-02" version="1">MPEKHLIEEIKKMNKKLKDLNTQIAANEYKLREVPNRKSEEKFNKVIEDLKREKEKGEEKRYLLQKVVKLQGTLETKEVKITQLKHQIEELQKNNGQIQELNEEIVDLKQEKDQLENEIIKLKNDIRGLKEKIEERDVRVELLEKEMKENHENHQNIMKDFIAKSDKDIKDLRYKTSANITQLKDNHSREMDEMRESNNFLENEVKELKTKLSKMESELNECKKHVSYCTEENKHILYIGQLCSDLQTNWYRYVMPKHCHDEHRAYKVNHIIDDIGDSTILSEEEQNDAKRRWKELQSKIDWEKNERLIEAIKRLRQQRNRAAHPKVLSEEGAKRAADELKKQGKLKAKPSFEDVMGLINLWKSSKSLHQGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GXV1</accession>
    <name>A0A6P8GXV1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116286662</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116286662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="8">Tentacle</tissue>
        </source>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549089.1">
        <property type="nucleotide sequence ID" value="XM_031693229.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Shisa"/>
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        <property type="entry name" value="GEO05642P1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SHISA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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    <feature type="chain" id="PRO_5028380245" evidence="6">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
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        <location>
            <begin position="91"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="199"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="267"/>
            <end position="291"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
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    <sequence length="412" mass="45082" checksum="E0081256178A65C7" modified="2020-12-02" version="1">MAVRTLLVLALIMVSVCRSHDKCLDSSDCEDHSCKSNSDCSALGRVCCDNKCSDGQKCVGQSCIVDSDCFQNQHCCEHKCSGDAICGIKNFTLVIALVVFGLAAFIIMILIVIIIIVKILCNSPRHAISACITTLQQQFYGAIGQPNAWALRHPICHFRTRLQSETGKELASIDLHARIAINICKTHYERDRSTMGLRILLLYTLFSVNYFCTSAMFCGCDYDQVCCNGLCLYGSNCLGNYCYSDSDCSFGEVCCGSSCSDSCSDNVGVIIGAVFSIIFGIFLFCVIVICCRRRQTVRTVQRPILGQRVIARTTTTTTTRNYRRVPNYPHQGPYQGQQPYGYQQGYVRPPPQYPGYGATNPIAGAYQSGSNAPPPMSVAQPPPYEEVPAVVAMGNGCTDQKNNYPQASAPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H085</accession>
    <name>A0A6P8H085_ACTTE</name>
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        <submittedName>
            <fullName evidence="13">Adrenocorticotropic hormone receptor-like</fullName>
        </submittedName>
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        <name evidence="13" type="primary">LOC116286418</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
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    </dbReference>
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        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
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    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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    </dbReference>
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            <begin position="34"/>
            <end position="61"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        </source>
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    <sequence length="324" mass="37007" checksum="6F036A65017F7028" modified="2020-12-02" version="1">MDSVNSSKSQVCPSDFPISFSKVQYQSSTINDSAIFFVILFNVIICPFAITFNTAMLTVIIRDPNLLSLKNTSILFLTVADLLVSTFGQISFIANELGILIHGRLQCSAVFATNLYTELFTIGLSFFTLKVMTLERFLAIFCPYWFHRWATKRRVCFAYALTWVSWTSYITVVKFSPEIPESTYTSVLTGFIFTNLLFTLSVYSKINRLRKQAHVTPNINQHKTAEEIAQRRASRTVVYINAALFISYFPTFLVGILHYSKIVTDDVLIYHVLYPLAQTVSFKSAVVDPIIYAWRTSEIRESLRRLLRKKGLSRNNRSVQSRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0Y0</accession>
    <name>A0A6P8H0Y0_ACTTE</name>
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        <submittedName>
            <fullName evidence="6">Protein kinase C and casein kinase substrate in neurons protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116286613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
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        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons 2"/>
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    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FCH_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="299"/>
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        </location>
    </feature>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51741"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031549026.1"/>
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    </evidence>
    <sequence length="366" mass="42017" checksum="5448E6637F89CCD8" modified="2020-12-02" version="1">MNHNMDENGDKSENNKPGTKLHQTIPLTSEPQFDFWHVNGYKKTVKRVDDGSKLCDDLTKMITERADIESNYANKLQGWSKKWTDLISKGAEYGSCNSSWLEVAKEAERLSTIYSELQAMLLTQVCQSISTWKGQHYHKSLLSWKETKNAEEGFSKAHKPYAKRYDTVLKCKKSYFAACVARDQVQKQLDNCTTSSPQTDEQKKKLNDKLTKAKNDVVTTQSDYKEAIRDITSYNPKYKEDMVFMFEKLQESEKERKIFMKSTMQSICQVLNPTHIFERYSQIHDSLSRFIENCDPATDISWWAATYGTDLPFHCVEYEEYNPKSTEEQAVAVREAQKPENVKKASPTDGDGSGLKTEKSSVCTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1U4</accession>
    <name>A0A6P8H1U4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 594-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116286913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549366.1">
        <property type="nucleotide sequence ID" value="XM_031693506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1U4"/>
    <dbReference type="GeneID" id="116286913"/>
    <dbReference type="KEGG" id="aten:116286913"/>
    <dbReference type="InParanoid" id="A0A6P8H1U4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031549366.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="20776" checksum="CD59EF2355F182CE" modified="2020-12-02" version="1">MDCLKCKKVFSTKQRLQYHVWHGVCTKKPISKVCNDCNREFSTLQKLQYHVKKGVFRRTTQCSYCAKVLSSRQRLQTHKKRHEKSYQFFAEKYDLEGVDCYQCGDLMSRCEHKDDYLRNQIDYFRKLSRTLPRFDALEGVPWTNREYWRQQCERCGCVREEEHIFNCLSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3L2</accession>
    <name>A0A6P8H3L2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cryptochrome-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550954.1">
        <property type="nucleotide sequence ID" value="XM_031695094.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288319"/>
    <dbReference type="KEGG" id="aten:116288319"/>
    <dbReference type="InParanoid" id="A0A6P8H3L2"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF30">
        <property type="entry name" value="CRYPTOCHROME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="502"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="787"/>
            <end position="794"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="818"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550954.1"/>
        </source>
    </evidence>
    <sequence length="1000" mass="115040" checksum="669C40CA3C1368B6" modified="2020-12-02" version="1">MVNSLHWFRKGLRIHDNQPLRDAIQXSTTFRAVFFLDRTTVRNAKVSVNRWRFLLECLKDLDNKLKEFGTRLYIVQGHPIDVFPRLIKEWGITRLTFEYDSEPYPSQRDLAVRRLAENEGVEVIVKSSHSLFDISRFVKENNGQAPITFKQFHSLLRKVGLPEACVETVDKELFGSCVMPIEDDHDEKFGIPSFEELGLAVEEEKGPGVWVGGESQALKVFQTAIKELFESNEKNSKYSDDSPFPKSTKLSPYLRFGCISPRLVFHKMTKLASKVSNPAACFGIQKSLLWREFFFVIASKNPALDKMCNNCMCLQFPWDKNNNSLERWKNGKTGFPWIDAIMRQLRKEGWIHHLARQAVGCFLTRGCLWVSWEEGFKAFEEMQLDAEWSLNASCWLWLSCSAFFNSTPTPWFCPVNFGKKLDPAGNYVRKYVPEVRNLPTEYIFEPWLAPVEVQRQAGCVIGTDYPKNILDHDIARKICSNRMRDVYNGLVVKVSSAPGLGHNVVHWFRKDLRLHDNPALFEALPNCRTFYAVYIFDPVNIKAAKVSANRWNFLLECLRDLDNNLKKCGTRLHVLRGQPTTIFPKLFREWNITKLTLESECEPFGQQRDEAIASLAEEYGVEMSSRSSHTLYSIDKILEMNGGKCPTLFKEFESIIRKLGPPDSPVDPVTRKCFSACICPINGAHEARYAVPTLSELNIDESQVTCGDLWVGGESEALTRLTELEEKIFIGTKRESPESAAALLPSRTQLSPYLRFGCLSPKMYYKRLTMAYIKMKSKPPPMSLYCQLVWREFFFTLASKNPNMDTIENNPLCLEIGWEHNEEALTCWKEGKTGFPWIDAIMRQLRQEGWIHHIARQAVGCFLTRGCLWVSWEEGFKVFEELQLDAEWSVNSGSWLWLSCSAFFHSQIPWFCPVSVGKKLDPSGNYIRKYIPELRTMPNKYIYHPWTAPEGIQKAANCVIGKDYPKPIXDYVERRKVCLQRLKEVCCQIKTTTESAICTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4X7</accession>
    <name>A0A6P8H4X7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116288015 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550593.1">
        <property type="nucleotide sequence ID" value="XM_031694733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4X7"/>
    <dbReference type="GeneID" id="116288015"/>
    <dbReference type="KEGG" id="aten:116288015"/>
    <dbReference type="InParanoid" id="A0A6P8H4X7"/>
    <dbReference type="OrthoDB" id="5974457at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="305"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550593.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50524" checksum="F81DA288C70B13B0" modified="2020-12-02" version="1">MNGHSKVTRTGSSGVYSDVSSSVDLSSSVGSTGSGNGLANTMRPASNLEKLLNQLPPELRKTTWDLRKQVAIHLNPLKDPIGNDYRLVGSRLGFQADIIEGFGKSPDPTMEMINLCMTTSCQEFFNIVHNAGRSDVIEDLLSYLNHSSNHYCLTTQESLEDEYLSRPFEESCSNVSKLSKQPSEQEESEVKEQKPGIPFEGSREFWDGIPGPYSQKKWKDFCAAMRKACPDESDHGGIEKFLCHILKIDFDSRLTDGEVKVEYFLRLLACFGPFEPGKDGCLAKMYELMKKSLSKSMNGNQWHSWFAGYMSSEETHERLSKQTPGYFLIRFSGSRVDDGWFILGVKTKDDVVQIEIKRDIDNRQHLLAEETFPDLASIVEKLRGDIFLQECRQLLINPCPDLPLNTNFIGYTKVSRNQGRGRGRGRGRGRGRGRGRGRGRGRGRGRGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5G4</accession>
    <name>A0A6P8H5G4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116288884</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116288884</name>
    </gene>
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</entry>
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    </evidence>
    <sequence length="2236" mass="252916" checksum="4536751DD1DA65A5" modified="2020-12-02" version="1">MFARGHHTKETPLKSNHVKVELLEGSGVGKNNNIMLGAAIPKQSRKNSTFSKNDSNAGSAKAFDKKVLPDHKNLTSLNLTHVSLPPTKKVVINPETGTKTHFYKVAQDDTTGFMEGNDKKITKVKDNLQHGVKSKMLKKDHIGILNGTNLSYIKAKVQTPRAEMKHVQNVTKSQNETQSFLSTIHNNSDVAMKMNELRNPLLHHIQNVSSNQDIVQFSAESHKHKSKVHHRHHHVGHMNPEDIGDSDFDILMSNDIPRKLKKEGKEKASKKKVEKKKKKKTAKNKKVVVGEDVSEDEDDETEKKSKPRKKKEKTTHHKHHKSKDKSNEEPWFKGHIKYIKKIKKKKPNHDTEDENNEREVTKKHEIVHHHHHHHHHHHHPTESNDNDDNEKDEPKHHKKVQEDEYKDDDEDGYVVNHHNQRKHHVIHHHEKMEPHHKIHHKFNENESGDDGGNNDNEKEVKKPYHVKFVHHEDDQDEEQDVEVHHKPKYREKSYHNDEEINTRIIKKRKKHHHFHHKDEDEEENDGDEEARHKIFNRKHHPHTYHYKSGDYDQRGEHNEVDNGRYRHRFHHPVKHWRHYEGEHHWHIKHPFQKTRVFLGEDAEGDDDDDTDDRNSQKHSKHRQYEDNWEDSRKEKWRKEEREKKYKSEEKKEKLMNEYENRLRDHKEYKHKTHKDFEGKESYEDESHWKHKHRESDRNYASYEDEETNKKHHPFGRERYEEWNEHGEPRPWEKESGDKFGSHEWKGKEHEYENFKHKKLHDGEEEYFGSSRYRNRPYEEHEPFQPWDEKKHEEHKTFNRPWSDHEGQQDHYEHEGQQDHYEHSNEKEWIPPWKQHKWNSHNQWEDNPNDHYRPKDEGKWMDKMHSFGSQPKSTPWPMNKETTYNPYHQSTLPYQTAWNSGTSKPQPYRPTQSGTKSSQGPNVNPWNQNYAGNVVDEKNERSDIARKPPQNPVMPYNNMIPNVTQGVIGVGVNSQPIPQGQNDWNSGPGQVRGSNQSPLNQGLPVNKGIQGNQGFQGNQRNQNNQGIQGNLGNQNNQGFQGNQGNQNNQGIQGNQMMNKSMNSPSWPGNNNNNIQNFPSMLQSPNQIQAPQVNAVNPNMAGNSQQPANTNPNQPNGFVNTNGASGGPNNVNQPTVKNGLPTRNLNTLKGFFRNETVGSSGSSLIGNQMPPTVGHPPPPQSSLPPPPPPPPPPPPVTTATKPTTTPTTVPVTTTHPTTPSTTPTKPTTPKPTTPKTTTPTPTQEDIPIPPPADLNDIEGIEGIMGEEGSKHRKHRDPVCKAGTITDDMTLLQGKRAGNFTKIGDVGDFELCIKRCCQSKSCDLAYKSGESCYLVHCHSKDSCQVTPALIKRYSPNMCFVRRSFDEEAEEQSDGIREVCKAERALGIDWKKTSAGHYSKVPCPREAKGKARRRCGADSRWHTPEFSDCVTSDYLKIYEKSRKLAGADPGADSSPLIRELSQLTTQTLDNSLIFGGDLIKSTEALSSVVQHNGRNDLLDMNRDDMQNFVTTSSNLLDLTNRQEWVNVQKKKPGSADILRSMEMFALQAAIRLPREDIKKPFITNNIVMNLDRRSARSGRLIFPDYSDSDISKWDVRHDVISIPSSVFKRGEVSAASISFKSLPYLLPDANFSRGLGPNSKILSTILHPAPPDEISPPVTIILSHIKPKRANPKCVFWDYTINPHRGGGWSSRGCSLASSNDTHSVCQCSHLSNFALLADLSDDEISAKEQKRERTMALMWIGIPVLVVGVIGALYMSFSWTGKSQMTSRQIDEKTGLLGQRVVTSQVREDFPASPSRNLHRALSPAYTPLPPGDLEWQDEFRHELGISQGDKFAKELYLPQLDKLKTHLSKEYPKKFNSVPKSSMFTRIHSDHQNSSSPLSPPSPTSSSFSWDSGYMSASSASLVSSMESALPYSPVSSPLLSSSFRDAMLLGSESETGKDLTITISELSSSSFQVPSLSLSLSSLSSSLNELPRETLIAQDISTSAALSSSASFETLGNISSSSLGLDTFGMCLRYSQSNERLQSGVSSSVVRHNNVTSLSRETEPLRTAIQDSLPAMDDTLEPWTLWEQSNNSDSTSWSPTTPSQSPLPSSSSSSISSSSSSSSSSSSFSSSSSAGAAHLLTSSYSSSSASSSSSSLSSSSSSISSSSSSTSSSLSSPLLVSPIPSLSSQLSINSSSNGEYGLQAARNTRVRFADEPLLWQYEDEEHELRIKTLEKRVFSQRLTRSTGISKLNMADTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9E5</accession>
    <name>A0A6P8H9E5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553079.1">
        <property type="nucleotide sequence ID" value="XM_031697219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290211"/>
    <dbReference type="KEGG" id="aten:116290211"/>
    <dbReference type="InParanoid" id="A0A6P8H9E5"/>
    <dbReference type="OrthoDB" id="10336826at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028115652" evidence="2">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553079.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15421" checksum="1A730A6287924F5A" modified="2020-12-02" version="1">MKGIXLAIFTVVLVGRLCAAFPKTATKVRSSLEPGKELKEVKYDQELVSSFEWRELLEHIPDSLFPILEKILKGIARSRSPEDIIKAILTRDWKYLGGKKDKRRRRRKNKKDKKKEEEETEKEGETKEPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9N8</accession>
    <name>A0A6P8H9N8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Unconventional myosin-XVIIIa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116286766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549200.1">
        <property type="nucleotide sequence ID" value="XM_031693340.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H9N8">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="GeneID" id="116286766"/>
    <dbReference type="KEGG" id="aten:116286766"/>
    <dbReference type="InParanoid" id="A0A6P8H9N8"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01386">
        <property type="entry name" value="MYSc_Myo18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036064">
        <property type="entry name" value="MYSc_Myo18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF36">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-LIKE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="350"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="547"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1509"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1597"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1998"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2059"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1355"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1116"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2059"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2134"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2149"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2171"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="640"/>
            <end position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031549200.1"/>
        </source>
    </evidence>
    <sequence length="2206" mass="250696" checksum="500C17F5F4818435" modified="2020-12-02" version="1">MLSFRFPSIKRKKKEKDKTETKEEKRERRKREKAEKEIRKQEKKAHVNAQQPDPAIADIVAGNAIVEDEKKGTRFSFRKRKYDVEHEYDDTKSPDSNETVEIRQSYHSTGSEGSGSPSQRYGSPRGSINKGAYNDQDYDDYYQNGVHNNESNRGQGSGGPVPASRKRKTSSVEIQLKGDSSNGSDSDRDRATERSTAYKMEKNEERKASKSHGFPPGGRTIALSGTPKGDKQNSDSSAPPKPPRVVKADESGMVELRLVNAGKDRPAIHMSNKPREVVTTSTITNTYSAPFEDFMDASMEEKPIQAGNVQRLESGVAIDVTSPSEKSFDDLGVEFSLPEVVPASPGVPRVIKIQRRLSGDFGFALRRGTSSGSDKTVHFVEPVGPNTAAGILPGDRLIEVNGVNVEDVDREKIIEMIAKSGNEVVIKVVPVSELSELSVRSGLDGSTVQLDESNLKAGTLQRSGSKRMKKKPKSAEEAASQKAWQDAEKVWVVHKAGFSGGRVQRIKPAAGEEEEDTPMCKVKLDHGGEVITIEEESIEKANPPQYDRAEDLASLRYLNESSCLHTLRQRYGSNLIHTYAGPNLIVINPRQHLAIYTDKVIQMFRGCKQEDMPPHIFAAAQTAYRNMMASRVDQSIVLMGSTGSGKTTCAKHILHYLSVTAASQHSPVTDQKFEGIFALLEAFGNASTHLNNNASRFTLLASLDFDSAGMLTCGALQTFLLEKYRVVRQNDGEGSFHVFYYLLAGSDPKLRKELQLDKALKEMNDFISGFDPQAAETHKLSEKWTEIEFALNMLGITSDESKAIWSTLAAIYHLGGAGITMGSDNKPYFSNPAAVQRAASAIGTTQEELSEIIFAPPPVNQFTIRMRNKTDSPTPPSSAEATPERHAKGVAASYIEALEGFAIGLYQEAFNALVRLINRSLQCGIRSVSTMHILDAPGFQNPPTAVKENGASFEDLCHNYESERFQKFFHHTVFNAQMERYSQENIECSFESVATSPEPVVNVFDKAVKGLTRGSTLDLKNEQKGLLWILDEESIFPGANDSSFLARVYVHHCSDKQSWVKQGPRKDTFYVNHSQGTVPVLYNARGWLKLAREHSTTKQARGVLSDSSKPPIADLFSTSNTGESSISRSRSFKRTSMTPPTAIKKNSQCLQLIYQVDTILEAIRKTKVNFVRTILPLIADGLQQEGADKDKEVASLEVPLVRQQLRAAEMLDAIRIHRQGFPEHMPFAEFRRRFDILAPAEHRNAGPFLDEKKGVEALIEHLDLDKRSYRLGLSQIFFRAGSLAQLEDARDEKNTGTIVELQAHCRGFLARKKFKKLQVQNRAMICIQRNLRLFAAVRSWPWWRLYTKVLPLLNVHRTEEQLQSKTGEVEMLKAKIVKLENENREYAVINEKLEKKVSELSNALAEDRATANHASQVLEEESMERMRLERSLQELQESYEEIEKKNKKLETNLLEAQAIASSATRPIVKLERLERYEGEGASNDEDDEEEDTFYRDRYIQASRQHEELRRKIQGESEQEIEDLTNQKRHLERKLTDEKAENDELQRVVTGLKKKSSRINAEMQDLKLLLEDEQTRNSELEKKQRKFDLEANRLKEEVSHERSLRDKINREKEKYQSEKYRLEQELESAKDDVERLTKENHRLTNDLNDVAGNLGTKGDADTITLKKTIRELEQKIQDQEEELDEQAGEIQVLEQTKLRLEMAAERDKQLVHKELEAKEEELEEIRFSMQKKIKQMEGQLEDEYQEKTASVKAKRELERRLQELRDNLERGNVENEKRLKRELKRTKALLRDAQTVIEEQEKKLKDRNQMKALKDKLEDAEYAAHAARKAKKKVEEELKDVQSQLDSVSKSKLEIENRYFVQLKELTSLQSRVEEDEEDMETLTEKNRQLIKQVSETQTQLRDTENLLHDTITEKEALELKISTMSSRLDYLEGSTVDKQTLSTMDSKMKELESKLDFEGTFKKRQDTQVNRLKEQVLRLQEERDECLLRETKLQQENMKLERHMREMKDETSAIEKRDGELKKKKSEAEREVESLEIQLASTKQELALSKKRVAELQHALEDDMHSDSDRLSDGDLSDDSDLNLETSSRVPSEPRSYRSIEDLDERDELDSKLKKKLREFKDSSIDSHSGTSSPADSSTRKTSANLSPRSEKGEDRTKHTDESSKRKKSAEHKSRDDRRKKSIEKRKSLERMSRKAKEDIPGAFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAQ1</accession>
    <name>A0A6P8HAQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TATA-binding protein-associated factor 2N-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553544.1">
        <property type="nucleotide sequence ID" value="XM_031697684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290613"/>
    <dbReference type="KEGG" id="aten:116290613"/>
    <dbReference type="InParanoid" id="A0A6P8HAQ1"/>
    <dbReference type="OrthoDB" id="441278at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000320">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553544.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="35503" checksum="A043D042BE6A28DA" modified="2020-12-02" version="1">MVVVQVKVQAFDEKMMEPEIRRFSIDNEEVTSFAALIDKIKGLFPDLQGKEFEIFWIDDELDQAILSNDEELLEAVRVTAAKDVLHILVNTVMENDVRAKQEACQESRSDEAVFECPPCDNEKLCSECKQNEVHREQRMEPSKKPYFCGRHRKVCHFHQGVMGTRGCMMGGRGGMMGGCGGMCGRGRMMGHRGCVGGQGGMMGPRGGIMGPRGGIMGGHGGIRVTRGGMGHEGIISGHGGIXGPRGMMSPRECMMGGQGGVTGGHGGIMSGRGGMMGGCGGMVSGHGGMMGGRRGMMGGRRGMMGGRGGMMGGRGASMMFARGCMASPREKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBK8</accession>
    <name>A0A6P8HBK8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552513.1">
        <property type="nucleotide sequence ID" value="XM_031696653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBK8"/>
    <dbReference type="GeneID" id="116289708"/>
    <dbReference type="KEGG" id="aten:116289708"/>
    <dbReference type="InParanoid" id="A0A6P8HBK8"/>
    <dbReference type="OrthoDB" id="5986347at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038800">
        <property type="entry name" value="CCDC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33820">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33820:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552513.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43103" checksum="BFFDC04A58FCE0E6" modified="2020-12-02" version="1">MDTWKCDECNMKFDSRLLYDTHKRKFCGMLGGPPAPGSSRIPQRGYGKTMVHTGRRGKSISPKELVLSLGEKSPQNFHYHPTRISTAGSSVHDVSQRMSALEQEKVEELKAFKASMSLQRAYQHSKINSGPGRKVPDSRQSRSSPNYQLDRTLFDDQLKQLEDNHQEQLDQLRAHNERLKEEKLAIQEKMNSLGLKSRHKLVSQGSVDKQEAEFEGLRKYLDYKSQEMRNEYQAEMDKLKDLKKKIHGRYSLSPETPLSTKRSSPAEQPRDTLKLYNTGAQNHNPLNVQQASPIPLPQYAALQGSGLLGEINAMEISYLQGGGRDPEVLSQIKQLELEAKSLQPVSTAVPDPSLQQQIMAYHLANQKLEQELQLLRVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCD1</accession>
    <name>A0A6P8HCD1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-arabinitol dehydrogenase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116287780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550337.1">
        <property type="nucleotide sequence ID" value="XM_031694477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCD1"/>
    <dbReference type="GeneID" id="116287780"/>
    <dbReference type="KEGG" id="aten:116287780"/>
    <dbReference type="InParanoid" id="A0A6P8HCD1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550337.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38966" checksum="E29819801EEBB759" modified="2020-12-02" version="1">MNNSLQLWDGNLSFITRPVPHVSAPNEVIVKVSYSGVCDIDVRILAGELPVSHCVVLGHEFAGVVSEVGTEVKNVSIGDRVVINPHMSCHLCCHCTRGQPEFCEKEQDQFLGIWRNGGWSQYTRVRAQNVHVLPPQVSLRHAILCEPISCILHGFSFLHPLPTNSKILVYGSGIMGTLWLCILHFHGYRKVVLSETSEHRRNLATGLNLGFKVMHPDTIEAEAYDGQRLDKNWGFDALIDCTTSASDFQKSVKWMTNGGKILLFGCYPQDSEVKLNPYDILNKELKIYGCKSNPFTFPQAIQLVRDMAEIYFNFDKLGIHLFQLTKYETALSSLTKEHVEKVVFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCX8</accession>
    <name>A0A6P8HCX8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-queuosine alpha-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.110</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287983</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>queuosine(34) in tRNA(Asp) + GDP-alpha-D-mannose = O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12885"/>
            <dbReference type="Rhea" id="RHEA-COMP:18572"/>
            <dbReference type="Rhea" id="RHEA-COMP:18581"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="ChEBI" id="CHEBI:194442"/>
            <dbReference type="EC" id="2.4.1.110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12886"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.110" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031550557.1">
        <property type="nucleotide sequence ID" value="XM_031694697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCX8"/>
    <dbReference type="FunCoup" id="A0A6P8HCX8">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="GeneID" id="116287983"/>
    <dbReference type="KEGG" id="aten:116287983"/>
    <dbReference type="InParanoid" id="A0A6P8HCX8"/>
    <dbReference type="OrthoDB" id="10032790at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016438">
        <property type="term" value="F:tRNA-queuosine(34) beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051862">
        <property type="entry name" value="GT-like_domain_containing_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022701">
        <property type="entry name" value="QTMAN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13615">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13615:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12038">
        <property type="entry name" value="QTMAN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA-queuosine alpha-mannosyltransferase N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="217"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031550557.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44958" checksum="25DFBDCDA590CB9A" modified="2020-12-02" version="1">MSESNDGTTSAYLASWTKNDKTIEDSDDVQRSTQSDEGHVLLIEPFYGGSHKQLVDLLVQKIPGCVKFCLPAKKWHWRVRTSALYFAQCISEVHQYRILFSSSVLNLAELIALRPDLTDLKKVLYFHENQLVYPVRKQQERDFQYGYNQIISCLVADVVVFNSEFNMNSFLTSVDSFLKLIPDHRPKGISDQIKPKCRVLYFPIPQITCNTRLSRPNDHPLHILWAHRWEHDKNPESFFDAIFHLLEEKLDFKVSVIGETFSEVPSIFAEAKTRLGYKVINWGYQQSREDYEAVLMDADLAVSTARHEFFGVAMLEAVQLGCYPLCPNNLAYPEIFPDVYLYSTQQQLAKKLRYFCKNPGFVRNHTLKVDVSRFSWENLGKDYQNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDC0</accession>
    <name>A0A6P8HDC0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Adenosine receptor A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116290196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553063.1">
        <property type="nucleotide sequence ID" value="XM_031697203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDC0"/>
    <dbReference type="GeneID" id="116290196"/>
    <dbReference type="KEGG" id="aten:116290196"/>
    <dbReference type="InParanoid" id="A0A6P8HDC0"/>
    <dbReference type="OrthoDB" id="5978165at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="47"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031553063.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49792" checksum="1D2262AC49BF7FCE" modified="2020-12-02" version="1">MNNTTSRNPIKTNDTNISGHDPFYRTQVAIIAQTASLAVLGVIIVLGNLASIITFVKTQSLRRRCHYLIICLAVSDLLVGVVDFMSAYFFWTGPQWNTFLVVLEFMDTLTGIASVMTLSNIAIERFYAIFYPFRHRRLRFRVYVALCAFPWITATYISALYITSVYYSTSILKIYTYHTFSVASIALLVILCSYITIGVKLRNNNPSAQNQNRPSRDQKLAVTLLIVTLASMLTWLPLQCFLVVLYFCLSCPLPHFNLLFVMKFLQFCNSGINVFIYIVRMPEFRSAFLVLFCGKSEQNNRAQESTRMTSTASVINNGFVGNQNGSGNTCRNRSTAGPKNNSNLPSHAHNNLQKLQPESPYQFTNSSAQNDGARTHSSNSNPTNQNPRNCNTENQNAKESESCNIKQIYLTKEGDSLLDQSGYQQGVTNNACETEASGIEDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDF0</accession>
    <name>A0A6P8HDF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290744</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553706.1">
        <property type="nucleotide sequence ID" value="XM_031697846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDF0"/>
    <dbReference type="FunCoup" id="A0A6P8HDF0">
        <property type="interactions" value="3231"/>
    </dbReference>
    <dbReference type="GeneID" id="116290744"/>
    <dbReference type="KEGG" id="aten:116290744"/>
    <dbReference type="InParanoid" id="A0A6P8HDF0"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF18">
        <property type="entry name" value="LD43650P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="134"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553706.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34695" checksum="69317AD550730EFA" modified="2020-12-02" version="1">MAGMRYPGYPPDKNDKSPGLSLMLSLALNTATHPLTTVKVLVQVGHEPLPAVASKTIFGNPVMKLPGLLEYGKHIKKTDGFFGLYRGLVPRLVCGVIGSFVNDATLEALQSKDDPLSESFGLEPVEKEFKDEVKDFTIETCKQTAAKCIAVMVSHPFQVITVRMIVQYVGKETIYSGMFSSIREVFNNHGIFGFFDGVVPRLVGEVLSLWIYRTLHFFITQYGLDKEMAARKEINIYTTALSQWLSSLVTYPFTLVSNVMITNHVGLVAGEPPAMPVYTDWVDCFKQLRSSGDLWRGSSLLRRTAKMNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDY5</accession>
    <name>A0A6P8HDY5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tachykinin-like peptides receptor 99D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553901.1">
        <property type="nucleotide sequence ID" value="XM_031698041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDY5"/>
    <dbReference type="GeneID" id="116290920"/>
    <dbReference type="KEGG" id="aten:116290920"/>
    <dbReference type="InParanoid" id="A0A6P8HDY5"/>
    <dbReference type="OrthoDB" id="9876908at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553901.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41478" checksum="C49F0CE5FD006546" modified="2020-12-02" version="1">MNLTNSSLALQQNGEVCDISSSLGATVCKALAYIIIFFVSAIGNIIVIGVVLRTKSPRGVMDIFIVNMAFSDLFVPFLMVPKELFEVISGSLEWQVGGLVGNVFCKLYFFIADISPIVSTLTLYCITVERFLAVTRPKLPSYKEPKLHLIMVVLTWIIAMGYCAPYMYVFRLERVENPSEGTNGTTILSCGINWAPAFDHVTSHMAYITATCVLFVIIPFFSLTCMYTYLVIKARASYKIMAHSLSPRAKKRRAIKMWTLLKLSIAVVLGFAICWAPFNVGMFLLIFIWHGKPPTSCFFETYWFVAILMSASNAAVNPWIYLVFVDRFKKQLQEIRKSFSSMLSLRSLSPVQQSADIEKEGCGKMEPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE35</accession>
    <name>A0A6P8HE35_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: uncharacterized protein LOC116288283</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550907.1">
        <property type="nucleotide sequence ID" value="XM_031695047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288283"/>
    <dbReference type="KEGG" id="aten:116288283"/>
    <dbReference type="InParanoid" id="A0A6P8HE35"/>
    <dbReference type="OrthoDB" id="5984901at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550907.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24166" checksum="C27FA9F57274CDA5" modified="2020-12-02" version="1">MGELRNSNQGSSRTYPRDLCGKRKPNFTTAELNLXVENVENNKEILQSKLTNVITNKKKSETWELIVSKVSSVGVAERTVTDIRXMKVNIXRCKEANSESKKARRATGGGPPTADPSPLNAKIMEVYHDTPGFSGLAESFESGLPSDATVLPSIEIANIPSEEECSGVESKKKITQDDVLPAQYENLLIQKEIFILKKINLELELQHLGYDNQEVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFL7</accession>
    <name>A0A6P8HFL7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Placenta-specific gene 8 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553783.1">
        <property type="nucleotide sequence ID" value="XM_031697923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFL7"/>
    <dbReference type="FunCoup" id="A0A6P8HFL7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116290813"/>
    <dbReference type="KEGG" id="aten:116290813"/>
    <dbReference type="InParanoid" id="A0A6P8HFL7"/>
    <dbReference type="OrthoDB" id="5989075at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553783.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20307" checksum="94B0A84C97258C74" modified="2020-12-02" version="1">MMQQNQLIMTQPGQPITTQPGQPITTQPGQPMTLPGQPMMQQGQSMMMQHGQVAPMYSQNTTNTNVIMVNQQPVTARAAPREWSTGLCGCFDDCGTCWYAIFCGYYMLCEISQRLGEGRCFVYFCPFPLLSLRIKFRAEQNIKGSLCKDYLTVQYCYYCALCQLSREIDHVQRIQRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFW2</accession>
    <name>A0A6P8HFW2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116291655</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554701.1">
        <property type="nucleotide sequence ID" value="XM_031698841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFW2"/>
    <dbReference type="GeneID" id="116291655"/>
    <dbReference type="KEGG" id="aten:116291655"/>
    <dbReference type="InParanoid" id="A0A6P8HFW2"/>
    <dbReference type="OrthoDB" id="5950469at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028429744" evidence="2">
        <location>
            <begin position="19"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554701.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40390" checksum="42ECCEAA41824CE9" modified="2020-12-02" version="1">MWGLLVFVFASLFHLSEPFSPFTYMDKYLKGSQLRVIQVEDWYECIKQCQEELLCISYNFDNKSECQLNGHGVEKRCQAEDELTSSAGWIYHQIREVTRKTTRGKNQGSCPCNCGVSKQCYVEPEYGDVPEKAGSSCQDILNRRGSVPDRAYYLMGATKPVYCHMTSISGCGDVGGWTLVMKINGSKSTFRYNSQYWTSKMPSKKEYQPENGANLDEKETKLATFSSIAFQNICVGMKLVNFSSIRWLNKKISSGKSMMTIAESGYVTFGYDEAKWLKLLPGSKLDNGTKRDGFNVRPSSGDGARVRIGIIAYPKSDNAGVPISYIGFGAGGDAAASKHMGRLSCGNVNGMHYIPAFGYIFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG93</accession>
    <name>A0A6P8HG93_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine/tyrosine-protein kinase HT1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555424.1">
        <property type="nucleotide sequence ID" value="XM_031699564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HG93"/>
    <dbReference type="FunCoup" id="A0A6P8HG93">
        <property type="interactions" value="2546"/>
    </dbReference>
    <dbReference type="GeneID" id="116292281"/>
    <dbReference type="KEGG" id="aten:116292281"/>
    <dbReference type="InParanoid" id="A0A6P8HG93"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097527">
        <property type="term" value="P:necroptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="335"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555424.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="66468" checksum="FA75C8BC09299B43" modified="2020-12-02" version="1">MTQRSKYILLEKVLLEDENGPFEVPVGEILEEIDSSDYSIWSSDVFLFHARRQRKLTFSTKAVARLTDLHAANLLSIKSLKQRLTDFQARNCFAKPPKTGNQVFVSVRGREFKGIVRAVSSMSDNDSSFKVQLFNEVNLDEHFIQDGETLISMKTCGLDVLWHLPNGGIGVSVSLDKLRPRYETLSSNKHQTRAVRGEIENEKNRLLNSCQKSNMHKVALATKTEANDKEHERQLSCTKKDKEEAEKQLQSSEEKTKHLETTLPIASIDQQNYKNLQLKFNKLQQANGETQKRLQSCEEREQELQKTLAETQKLVKKKQEPDNECEWTLNREEIQITEEKLGSGTFGTVYKGMFRGTQVAVKQVSVKPKITEYNIENFRREMKMASRCRHPCMLQFIGATSDDQSPLLMTELLDTSLKAVLLERALNLVEIITIALDVAKGLNYLHLTRPHPIVHRDISSGNVLLWKHGQSWRGKISDYGNAVLMNYAKTGSGGAISYLAPEMNNKRFSPKSDVFSFGVLLLEMCLRKEPSCLGDRGELICLVENGELRSLIRSCLQKEPTQRPSMDEVLAALTTASSSHSELTGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGD2</accession>
    <name>A0A6P8HGD2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-terminal methionine N(alpha)-acetyltransferase NatE</fullName>
            <ecNumber evidence="5">2.3.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116291812</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031554886.1">
        <property type="nucleotide sequence ID" value="XM_031699026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGD2"/>
    <dbReference type="FunCoup" id="A0A6P8HGD2">
        <property type="interactions" value="2741"/>
    </dbReference>
    <dbReference type="GeneID" id="116291812"/>
    <dbReference type="KEGG" id="aten:116291812"/>
    <dbReference type="InParanoid" id="A0A6P8HGD2"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000078">
        <property type="entry name" value="N-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031554886.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18746" checksum="912C2DA825414B58" modified="2020-12-02" version="1">MKPKARSELGDVTVHNIKQLKKLNSVVFPVTYNEKFYKDVLEGGELAKLAYYNDIVVGGVCCRVDKSEEGRRLYIMTLGCLAPYRRLGIGTVMLEHVLKICEKDGNIDNIYLHVQVSNQGAIDFYKKFGFEIIETKKQYYKRIDPADAYVLQKTLKRSDNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGJ0</accession>
    <name>A0A6P8HGJ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable tubulin polyglutamylase ttll-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555529.1">
        <property type="nucleotide sequence ID" value="XM_031699669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292370"/>
    <dbReference type="KEGG" id="aten:116292370"/>
    <dbReference type="InParanoid" id="A0A6P8HGJ0"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053317">
        <property type="entry name" value="Tubulin_polyglutamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113:SF1">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555529.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="60081" checksum="C196DB43DFB72609" modified="2020-12-02" version="1">MWRSTGLTSSKDYKNRDDIKYRHSPPHGGGVQISNRLLQIIVGCLVFGVLLLFINXLQLRNLNHRSFDDGAAVQKPLALICGKDIHTGYLNHVFNVFRQVGYVTTETVNNQWDVLWSHEYPFTLDELKDQLHQLQAYQKVNHFPGSGFICNKASLAVSRFPFHPVAFEIPKSKDKFLKEVKTFPHKLWVEKSNGHRGIRIKSPSEIKLDGTSSDTFVEEFISNPYLIDGRKFDIGIYVVLTSINPLRVYIFEDEVLIRFCVKDYLPLDVKDEKQYVVGDEYTQPWELPSLAALWKHGKFSRKHTILTHLKKEGKDADKVWRDMHDAIKEVYVKKEVDLISSSSTYGSSRNFFELVRFDFILDENMNVWLMEVNMSPNLSSGSHSDNALMYEQVIFNLFGLVGVSNRLAHSTRSSPESEKDMMVADYNIVTSHDACASKECKMSCIHKSCQTCHQCLTVEQRSFLKAAYYEHVNRGGYRRVFPPPTNKEETRSQNSDHLSSSNQLMDLWFKQKCLQHSSWCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHI5</accession>
    <name>A0A6P8HHI5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289321</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552072.1">
        <property type="nucleotide sequence ID" value="XM_031696212.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289321"/>
    <dbReference type="KEGG" id="aten:116289321"/>
    <dbReference type="InParanoid" id="A0A6P8HHI5"/>
    <dbReference type="OrthoDB" id="2400221at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003494">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="1999"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="2333"/>
            <end position="2469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3368"/>
            <end position="3555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4820"/>
            <end position="4852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3368"/>
            <end position="3380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3414"/>
            <end position="3451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3477"/>
            <end position="3494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="3513"/>
            <end position="3553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552072.1"/>
        </source>
    </evidence>
    <sequence length="4852" mass="553081" checksum="14D65958105D00EC" modified="2020-12-02" version="1">[encoded data, 4852 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIA6</accession>
    <name>A0A6P8HIA6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289553</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552362.1">
        <property type="nucleotide sequence ID" value="XM_031696502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIA6"/>
    <dbReference type="GeneID" id="116289553"/>
    <dbReference type="KEGG" id="aten:116289553"/>
    <dbReference type="InParanoid" id="A0A6P8HIA6"/>
    <dbReference type="OrthoDB" id="10271983at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552362.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16917" checksum="01B75858A6514062" modified="2020-12-02" version="1">MSSLDHREQTMRHVPYFVACFLIFMTFVKAFPSQCKDDKFFDHVKQIYLPCSECENQQFECEICCSARKPELVDASISSSNAPRPSLKEKTDKAKYQILNLFLQSFIITMVICSLLVLFYVAYKVTQERQAAAECPQGNHFHNADAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIW9</accession>
    <name>A0A6P8HIW9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289826 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552612.1">
        <property type="nucleotide sequence ID" value="XM_031696752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIW9"/>
    <dbReference type="GeneID" id="116289826"/>
    <dbReference type="KEGG" id="aten:116289826"/>
    <dbReference type="InParanoid" id="A0A6P8HIW9"/>
    <dbReference type="OrthoDB" id="2021148at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027911422" evidence="2">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552612.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16777" checksum="FA807E6F831F44B7" modified="2020-12-02" version="1">MKRLSTLALCLILLIGIFQASASSEKQDASKRNPGPPLSKFGAFRDTIQDDTRRPPSRFGAFRDTIQDDTRRPPSRFGALGRDTTQDDTRRPPSRFGALGRDTTQDDTKRPPSRFGALGRDTTQDDTRRPPSRFGAFRDAAQDDIRRPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ32</accession>
    <name>A0A6P8HJ32_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292646</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555861.1">
        <property type="nucleotide sequence ID" value="XM_031700001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ32"/>
    <dbReference type="GeneID" id="116292646"/>
    <dbReference type="KEGG" id="aten:116292646"/>
    <dbReference type="InParanoid" id="A0A6P8HJ32"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555861.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19435" checksum="8AD44E1B0DEFFB77" modified="2020-12-02" version="1">MAAWAAVPSTKPNGDKVRKRSFSGGLPMLNRSGSMADKTLLGVLNILRMDEEAANTFLVRTILPDGNLRLVSADYNMTIRDLVTGIVQEFHLENYQVRELPGKTLADLNAKASSVENSEIAIEDVERRMSNFELDNIHAIKDPRLRCVKELLYEEEQFFNDLKCVFEVYAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJY3</accession>
    <name>A0A6P8HJY3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin delta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Delta-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116293411</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a positive regulator of hedgehog signaling and regulates ciliary function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556694.1">
        <property type="nucleotide sequence ID" value="XM_031700834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293411"/>
    <dbReference type="KEGG" id="aten:116293411"/>
    <dbReference type="InParanoid" id="A0A6P8HJY3"/>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002967">
        <property type="entry name" value="Delta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01224">
        <property type="entry name" value="DELTATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="38"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="242"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031556694.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="59820" checksum="3322E22362B77C2F" modified="2020-12-02" version="1">MSSIILPVGQCGNQISHELMTLIDNHSVSHPLSHRDGKLRCVCVDSEPKVIGNTLRSDKKRGNLFREENMVVGQSGRGNNFALGYYGLGGETEETSLLHRTMDVVRKEVERCDCFAGTIVMHSLTGGTGSGLGSHLVEALRDAYPLAHVMSVAVSPHLSGDSPLQNYNSLLSLAVLQRNADCVVVFSNDDVLRHLIAHRGAVASSRHPSSSSNVSLKDMNQLIAASLAGVLLPLGQKPKKILRKTSTNKTKISIRRNTSSTSSTLSDNERSAATNKKRSSLNPVQTRDRLSSSSTLSNYSFVCDGSIVHDEDGSESLMQKQPRATVSALLRYRGISSKSSGFPSYPDNTSLNQSTFRSSDSLSETVDVSTGNEPWEMLRSVCPEPSKKFSTIHHMSKAKVTWEALTQSLLHSTCRYDKHGRQFSTLNSLLIARGAGEKPFADSVTKIEERLKNALGCVEWNPFPLDFWISQYSAAGSRDAQXLTLCLNSSRIMGFLDDVMTKARTMYDVGAYVHWFEKHGCTKDEFLDAFSTLDGVVEEYRCATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKR0</accession>
    <name>A0A6P8HKR0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S31, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116293650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556969.1">
        <property type="nucleotide sequence ID" value="XM_031701109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKR0"/>
    <dbReference type="FunCoup" id="A0A6P8HKR0">
        <property type="interactions" value="1594"/>
    </dbReference>
    <dbReference type="GeneID" id="116293650"/>
    <dbReference type="KEGG" id="aten:116293650"/>
    <dbReference type="InParanoid" id="A0A6P8HKR0"/>
    <dbReference type="OrthoDB" id="5989925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026299">
        <property type="entry name" value="MRP-S31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15433">
        <property type="entry name" value="MRP-S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556969.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41780" checksum="0EB72571AD67D342" modified="2020-12-02" version="1">MSLLSRAFCTRYFKPTSFQRIAPIRYHRAYSTGSSDGGDKPSKSGISSLLSSLKRKDKNGDLKEILQRGKQLKEPQKDTLETVIGNENRVKSVAAEGSVKSSMERLSQSSVLSEDDVKAGTRDERLNARETPIPSPPFETTKTSDVSDTMKKMLKKDAANPTLSPEIHGKLKSILSKLKIDSAQTNLSKDIIGAAKSWGRVSPRYRKDIVSDYKMQSRKEALQVTREISLTDGARFNLFDNIFGHSVASKEPPSKLSLLEGIEMEMLLRYEALDQRNDFISLIEIADKQWKFPVDNEVCKVEEESVSFEEHVFLGYLLDGFPKKGPVRRFMELVINGLEQNPHMTVAQKKGQVEWFKEYFDNIPEGDLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNE6</accession>
    <name>A0A6P8HNE6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-glucosylgalactosylhydroxylysine glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.107</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acid trehalase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(5R)-5-O-[alpha-D-glucosyl-(1-&gt;2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:11068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12753"/>
            <dbReference type="Rhea" id="RHEA-COMP:12754"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:133443"/>
            <dbReference type="ChEBI" id="CHEBI:133452"/>
            <dbReference type="EC" id="3.2.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.107" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031557894.1">
        <property type="nucleotide sequence ID" value="XM_031702034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNE6"/>
    <dbReference type="FunCoup" id="A0A6P8HNE6">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="GeneID" id="116294435"/>
    <dbReference type="KEGG" id="aten:116294435"/>
    <dbReference type="InParanoid" id="A0A6P8HNE6"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047402">
        <property type="term" value="F:protein-glucosylgalactosylhydroxylysine glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000023">
        <property type="entry name" value="Protein-glucosylgalactosylhydroxylysine glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.420.10:FF:000003">
        <property type="entry name" value="Protein-glucosylgalactosylhydroxylysine glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028265655" description="Protein-glucosylgalactosylhydroxylysine glucosidase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="10">
        <location>
            <begin position="314"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557894.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="84709" checksum="7F406B58F180423F" modified="2020-12-02" version="1">MAFLGLAICVTVQFFFLSTTAMRPSPKKSTETLLYTKKMPSEDFSTVSITGNRAGNMMPTIGNGYIASVLYSDTVHVSGLYNGKAYSKFYPIYPINITQHTHRARLPSTCSLSFEVFGIQGDSSYALDIKKGIFYKWFDAVVNINETLTIEQRFYAHRQLRHLIVVEISIKNDLSQNVTLNISNNFGEYTNDIGLKQYTVDKELAMEMAYGEIKTVEEVDSLKSKVALAFQDIPDHIVIEAHDWKTWYYVTAIATSIDTKFDPWRQAENAWRLGEKRARFLQWHHTKAWEELWNSGSIDIDGNLELSQAVYASMYQILSSTRADWPYGLSPGGLSGGEEYMGHTFWDQDIWMFPFLLLLYPDLARASLQYRYDRLPAARRIARLNKYRGAMFPWESSLTGIETSPGWKYGKHQVHITGDIAYTARIYWYATKDIQWLRHIGFKLVYYTAEFWSSRVYYDKKKDQYQINYVMPPDEYQFPVDNSFYTNVVAKQNLEFALECGRILNRYVPPYWAKVAAKMYIPFDEDLQYHPEFDDFHDGLKTKQADAILVGYPLMYNMTREVRYNDLDIYENITDARGPAMTHAMTAIGWLEVGEKKRANRAFLKNFKNINGPFKVWTENINRKGAVNFITGAGGFLQAVLFGYGGFRIREDHLEFNPTLTPSSKKLSIKGVDYLGNSMDFVIKRKRVMITLTTKKEIIAPKLEVVLYNKVEELQYNKTVSVMRGKGKIRLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNM3</accession>
    <name>A0A6P8HNM3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb-like protein X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557276.1">
        <property type="nucleotide sequence ID" value="XM_031701416.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293919"/>
    <dbReference type="KEGG" id="aten:116293919"/>
    <dbReference type="InParanoid" id="A0A6P8HNM3"/>
    <dbReference type="OrthoDB" id="5986437at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557276.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64662" checksum="1C06802054BE11F4" modified="2020-12-02" version="1">MACCFGKTDTTDKGETEPLMGDQKKEKNSNQDNKKKPTKSTKLEFARLEVQEFDSVFSDFARTLNPFVTDREKLELAVTKFKTAVESIQAVRPQASFREYVVALKTKLKEERIFIKIKNGAVEVYGLAGRSIKGVEDAVSAIKTILATAETLKGMPEVVTTASGSSIQDAESSLENIENIIKREFSGIFDICKVVRFKKNLKGNIEKLKNAPSMVKDFCQEVKAIVEEIGEVLDDKRNDDDDNDDDNAAAVARSVGTRGREDESKDKDEDKDSNEKEDEAAAGRGSSAQKGKKKKEEREKDKKSKKDKKDAKKKEKEDYHKQLKMETVGLADIDKLFTDLGTSLNKFVATRDKMQQARESFEKTIKTICNFDGEKEFKAYIKELKEKAKEGKMQIYIDTRDGEIKLDSVKGVDPPAPYRNAVKALNDIKASGKETLDLEPVVERGVESCASDITKIEPLKDFKKLVSGVKETMALPKKVKAFNENRKKVQQAPQIVKELCLYVKQILGDIVNAFKDDETKEKTEETEEKDDDEKEEKNAGKDDKKQETVEAAVHASGXAPKTENIENIESNSNTVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP67</accession>
    <name>A0A6P8HP67_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554450.1">
        <property type="nucleotide sequence ID" value="XM_031698590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HP67"/>
    <dbReference type="FunCoup" id="A0A6P8HP67">
        <property type="interactions" value="1600"/>
    </dbReference>
    <dbReference type="GeneID" id="116291419"/>
    <dbReference type="KEGG" id="aten:116291419"/>
    <dbReference type="InParanoid" id="A0A6P8HP67"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554450.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37296" checksum="ADE3A9158F1577DB" modified="2020-12-02" version="1">MLLGNLLSGKEISNLIVLQDTIDASARPLLLCFVKSLLDRVDLVCLVCYEHPPSKFLKSLDAELQSRVECFDACTDYLKWNQDKESDEQNHLVHHDSDLINTIRKAINKRCSLNQNGEQLKVAIAMDSVSNLILQSVSNTCQMLHQLLQSKAAENVLAYKVEQIVCVVHSDLHENHIVHAFVSIATSILQISPLDQSQTDPAQGCQSEEVENYCKVLHIRRTGKVLKKRQRFLMNQQFEVKEFQEEDWTQKPEILKISEPEADPTANLPFNLKLTKQEEQARANTQLPYMHHTNTSEPLAGKESQIFYQPDDVDDFDEDDPDDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ11</accession>
    <name>A0A6P8HQ11_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sushi, nidogen and EGF-like domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116293835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557178.1">
        <property type="nucleotide sequence ID" value="XM_031701318.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293835"/>
    <dbReference type="KEGG" id="aten:116293835"/>
    <dbReference type="InParanoid" id="A0A6P8HQ11"/>
    <dbReference type="OrthoDB" id="5946070at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="12">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="13">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557178.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49213" checksum="B215C59A483661F9" modified="2020-12-02" version="1">MCSKVVQSGPKWFKFTVCFGQLLFLFLITWPCFRGKADECKNAIWLPEKSDSYLRNHTIQKLTVSSQSMCKIMCYLSDKQCLSYNFHQSSEXCEINDSDEFQYPEDLVNMHGYSYSGTKNGCQSKPCTANATCQAKFTHEGGFNCLCPSGFTGASCEIDMDECTTAHDSCPVHSTCMNTVGSYKCRCHAGYKRSGQDCLPRKGTKDLPGKSCLSILNTGYSHGTGEYWLDPNNTGDPIKAFCDMTTDGGGWTKLKRLYLQTPSIPFNNPLNSFDAAIAGGQNISENNIPTGQAMLEILQVMGFHQIHFYCHKKSVGEVVSIMTKNNTAGQDVVRYFTSPEATVDFPEACDSFDKLPEDTSILAKNCELWGKDKTEATTVNKWGSFKWHGGLRISTCPFAIMGAENYGFRCYHFSNSGSPVGYGSCDNESSSSLTVNDTWQIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ99</accession>
    <name>A0A6P8HQ99_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Zinc finger protein 527-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116293920</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557277.1">
        <property type="nucleotide sequence ID" value="XM_031701417.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557278.1">
        <property type="nucleotide sequence ID" value="XM_031701418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ99"/>
    <dbReference type="GeneID" id="116293920"/>
    <dbReference type="KEGG" id="aten:116293920"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001228">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031557278.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52499" checksum="F57F86A81D5EF780" modified="2020-12-02" version="1">MEKSWYSFKTKGGITLFYYNSDSGEHRWASSFEPLQCTKVQPEEVPLIKMCKNGYKMPKKKQKTYKSTGTETEEYILVQYTTSKSVRDIGINAVARNVFSSFDDDDDIAEPVSRSFFASSTRSPFASDQPLSKTQEIVEQVPDIGPNEGSLVDNLFAMEFSSALSTEDKLKGDSCNKFRQLQKSAGEPENRLPSVLQRVDSLVVSESIQVPTFSGYSYSTNEEGVENEVVNADRIENENDSPKGCYLGLRVGKEGRIYVKSEPDDEQLEQEIKDETNCKIKQEICQDDDDGGGDDGDGDGDGDVAKFSILDFLPDHPANEDGGSNSKRYPIKCDKCDKSFKKVSHLKRHMLIHTNSKPYSCKICSKSFREANCLKKHIRIHTGEKPYNCSICDKAFSQSQNLNKHMNIHTGNKPHKCKACGKAFSQHSHLARHKLIHTGEKPHQCTKCGKAYRTSSHLVRHQKSSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQT1</accession>
    <name>A0A6P8HQT1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555030.1">
        <property type="nucleotide sequence ID" value="XM_031699170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQT1"/>
    <dbReference type="GeneID" id="116291936"/>
    <dbReference type="KEGG" id="aten:116291936"/>
    <dbReference type="InParanoid" id="A0A6P8HQT1"/>
    <dbReference type="OrthoDB" id="5980853at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555030.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16638" checksum="5207BBB07FB4E98C" modified="2020-12-02" version="1">MESSGVLLPGDEIHLWCLHYVFLPIINRHLRKWKDTWVYHPLRTEQSKTPMQLWIRGLQYTWGTQTTESEEAFQPSDYDNYGVDWSGPVSTPEPESVEVPDTTCPLLENEKHLLTDVSNLTITEAIEAFCTNVSTISHIINHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS84</accession>
    <name>A0A6P8HS84_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline and serine-rich protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558028.1">
        <property type="nucleotide sequence ID" value="XM_031702168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294543"/>
    <dbReference type="KEGG" id="aten:116294543"/>
    <dbReference type="InParanoid" id="A0A6P8HS84"/>
    <dbReference type="OrthoDB" id="5968166at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028011">
        <property type="entry name" value="DUF4476"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042616">
        <property type="entry name" value="PROSER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14880">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14880:SF2">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14771">
        <property type="entry name" value="DUF4476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4476" evidence="1">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558028.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27159" checksum="328A6DA9F48DD875" modified="2020-12-02" version="1">MDPTAFATVKYEVRRLPCTDDKVQAIVYAQGNFYAEQVAELLYESSFDEDKMKLLQSACPKMLPASCVGILPILRSFRLDNKRVHAVELLSRQVTDPLNFPILNEVFPYAKERDTIRGIMTRQASCAPPPPPPTVVHSVGNPYPYGRPTPRVDPNDPVYXMAEKTVDVVAGGIASMIAPRSRPGVVVGRPAAVVYQTTVASGPCVAAASPGIQVIQTGPGFQPVPGVQYVHTTQPPPPYPQQQYYQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUW9</accession>
    <name>A0A6P8HUW9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel subfamily K member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116296347</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560214.1">
        <property type="nucleotide sequence ID" value="XM_031704354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUW9"/>
    <dbReference type="GeneID" id="116296347"/>
    <dbReference type="KEGG" id="aten:116296347"/>
    <dbReference type="InParanoid" id="A0A6P8HUW9"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF345">
        <property type="entry name" value="TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="182"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031560214.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34755" checksum="616C51096445A18C" modified="2020-12-02" version="1">MGVFFLNFLRALKGPTKNLLLRTTLFFVYLLFGAAVFQTIESGEERREKHHFELVRQNMAEKYNISEKDMANLFLEISKAVDEGYFDVNYDRWSFAGSLFFTGTVVTTIGYGKMAPATVWGRVFCIFYAIFGIPITGLMLKSIGERITEGIANFFRLVDRRVCNREPQSIHTKTVIAVFAIVISMVLLLAALAMEYEGWTYFEGLYFGFITLSTIGFGDYVPAHPSEYQNHPAFVIIFTAITFVYFTVGLALVSSALLAISRLFEDDPPWGFISLGMNQDDDDEDRITREKLQAHKLHDATKSDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV91</accession>
    <name>A0A6P8HV91_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">AFG3-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116296443</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560319.1">
        <property type="nucleotide sequence ID" value="XM_031704459.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HV91">
        <property type="interactions" value="2068"/>
    </dbReference>
    <dbReference type="GeneID" id="116296443"/>
    <dbReference type="KEGG" id="aten:116296443"/>
    <dbReference type="InParanoid" id="A0A6P8HV91"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="239"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="657"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031560319.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="76882" checksum="85C30513DEB09D66" modified="2020-12-02" version="1">MAFRFCSKPLQPWLNSSFIRTLLNTQXGRFSCSTRVLLTHKPLTQLCFDRLARFSSQAPKGFEKYFPGASKQSSKNNTSGNNNSSSNKKSGGSSSSGDGKGPGGNNQWWQNFFENYQQQIWLATGLALGAGYLLMYSGTPVREINWQEFRTNYLEKGDVDKLVVSCLLTYRKELIKLTPTLLIIGALIYFSRRLSAGSKGQGGIFGVGSSTAKLFNKETSVNIRFKKNPQQYHELGAKIPKGAILSGPPGTGKTLLAKATAGEAEVPFLTVSGSEFLEMFVGVGPARVRDLFGQARKNAPCIIFIDEIDAVGRARGRTGQFGGHDERENTLNQLLVEMDGFSSTTNVVVLAGTNRPDVLDPALLRPGRFDRQIHLSAPDIKGRCSIFKVHLKPIKKNVDEEKLARRMAALTPGFTGADIANVCNEAALIAARYLSPVVEESHFEKAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWFLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLLSTEQLLDKMCMTLGGRVSEQIFFGRITTGAQDDLSKVTKSAYAQVVTFGMNEKLGNVSFDLPREGEPSFDKPYSEATAQLIDEQARELINRAYDRTTKLLTDHKHNVEQVAKRLLEKEVLNREDMIELLGPRPFKEKSTYEEFVAGTGSENEDTRLPKGLQGLKDTSDNEADAPTQPGSGTIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVH4</accession>
    <name>A0A6P8HVH4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="11">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116293374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556655.1">
        <property type="nucleotide sequence ID" value="XM_031700795.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HVH4">
        <property type="interactions" value="1344"/>
    </dbReference>
    <dbReference type="GeneID" id="116293374"/>
    <dbReference type="KEGG" id="aten:116293374"/>
    <dbReference type="InParanoid" id="A0A6P8HVH4"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="185"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031556655.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="71905" checksum="28E5913F4B258E7F" modified="2020-12-02" version="1">MAETESSVQQSNPLSRKLNKILETRLDNDKDIVEALRALSTFFSDNSLRSRRNLRGDIEKRSLLISEQFESTFTTVKEQLDAVHAEITEMNNCCQEMTSRLKSARDQTSDLISSTTKLQAESNRIQMQEKVAEAFLSKFQLHAEEAKLLRGPRNVPVTEGFFVALARVKEIHSDCKVLLRTKQQIAGLEIMETMAMHLEAGYEKLYRWTQDECRSLTGDLPEISSTLSKAMELLKDRPVLFKYCLDEYGTARRTAVVRCFVDALTRGGPGGTPRPIELHSHDPVRYVGDMLAWLHQAIASEKELLHSLLDKSSGGRKASHPKLTEEETNEKAVLSHITEGVCRPFKVRVEQVIVSEPGAVTLFSLTNILKFYGXTISGILGEEAAVLTTVQEMTELATKMFFNSLSCHAGKLLEKVELPPPDLGPTESLKETLGLLQAVLTSHDASVIPLDARQTDYGRIISCLVDPALQMSVMSASHLNAADMAAYMINCIHQIHSALAVYEFTDKHLEMLAAQMDAHIDTLISEQASFILSRSGLGNVYTVYQENKNQKVPLSSVHGLDPQTAKAAMAKFDKYLSSPDSLRMPQCELLRTTRLRDTIHKRAVDAVCDAYKQLYNMITDPINNYTDPTTIVARTVQQVTNLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW36</accession>
    <name>A0A6P8HW36_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoglobin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116295795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559586.1">
        <property type="nucleotide sequence ID" value="XM_031703726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW36"/>
    <dbReference type="FunCoup" id="A0A6P8HW36">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="GeneID" id="116295795"/>
    <dbReference type="KEGG" id="aten:116295795"/>
    <dbReference type="InParanoid" id="A0A6P8HW36"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031559586.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17659" checksum="B481D1942CD4778B" modified="2020-12-02" version="1">MGCGSSTHSRLHQDSISIPLSTAQKYLVRETWETIDAHKNSVGKKTFLSPEFVNLKREELERANALHGHAKRVMKAVENAVTAMDDTESFAAYLEGLGQRHIARALKPSYLDAMQLALIETLQDLLESQWTEETADAWNILFRFIADTMKRGLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX40</accession>
    <name>A0A6P8HX40_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116293802</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031557142.1">
        <property type="nucleotide sequence ID" value="XM_031701282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX40"/>
    <dbReference type="FunCoup" id="A0A6P8HX40">
        <property type="interactions" value="935"/>
    </dbReference>
    <dbReference type="GeneID" id="116293802"/>
    <dbReference type="KEGG" id="aten:116293802"/>
    <dbReference type="InParanoid" id="A0A6P8HX40"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="168"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="278"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031557142.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="47221" checksum="FDF62C571E5EE860" modified="2020-12-02" version="1">MAAVVHLRRILSPKFARVFCPSRLTNVLNTRNCSSSIAHEASSFNSGLCFEMSEELKALQDMSRKFAREEIVPVAAEHDRTGEFPWDIIKKAHALGLINGHIPESCGGPGLGILDACVITEELAFGCTGIQTAIEANSLAEMPVVIAGNKEQQKKYLGRMMDDVLMAAYCVTEPGAGSDVAGIKTRAEKKGDEYVINGQKMWITNGGVANWYFVLARTDPTAKAGQAFTGFIVEADSPGITRGRKEWNMGQRASDTRGITFEDVVVPKENVLGAEGLGFKIAMGAFDKTRPPVAAGAVGLAQRALDEATKYAMERKTMGKPIFQHQAVSFILADMAIGVETARLAMHRAAWEIDQGRRNTYYASIAKCLAGDVANKCATDAVQVFGGNGFNTEYPVEKLMRDAKIYQIYEGTAQIQRMIIGRELIDRAKMTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYI4</accession>
    <name>A0A6P8HYI4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Melanocyte-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116294263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557682.1">
        <property type="nucleotide sequence ID" value="XM_031701822.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A6P8HYI4">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="GeneID" id="116294263"/>
    <dbReference type="KEGG" id="aten:116294263"/>
    <dbReference type="InParanoid" id="A0A6P8HYI4"/>
    <dbReference type="OrthoDB" id="5972388at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557682.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37772" checksum="8283D7A44A35B07C" modified="2020-12-02" version="1">MDVNSTTKLCPCLKISHNDDSRNFVFTADIICVIINAFLSIPSMILNLLLILSIIKTPSLRKPSFILICCLAVTDFGVGLLIQPLFIARKIAFLYSNVEVYCSLLKAGNVLSHIVCSPSFFVVTAISIDRYFAIRLQTRYKQVITNRRVYKFLIGCLMGACLVTTARFHATRPEHMGYAAALMFILLVVIVCCYIKSLNKLKAHHVHIHNLHTPSQRIIQTILHKKTLKTLLIITSVLFICYIPFVTVVIVISKFGRNRSLTIAWEGTVTLVYVYSFLNPVVHLCRCKQIRQACVALMRRNKVGVAMLEPSVLSFQSTLEKYRWKKNVKKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYV9</accession>
    <name>A0A6P8HYV9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116294388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557845.1">
        <property type="nucleotide sequence ID" value="XM_031701985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYV9"/>
    <dbReference type="FunCoup" id="A0A6P8HYV9">
        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="GeneID" id="116294388"/>
    <dbReference type="KEGG" id="aten:116294388"/>
    <dbReference type="InParanoid" id="A0A6P8HYV9"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040055">
        <property type="entry name" value="Ribosomal_uS10m"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13334">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13334:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US10M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="77"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557845.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23749" checksum="5957273F11C3B794" modified="2020-12-02" version="1">MALKCLGQRLFLGLTQTTHSLFINQAIYTKGNALALAPCFLTNKLGCFNVFMVGHYSSQLQASGSDFSDDTLYPLVSVKVKGSDEAVLKSYTHFVTRAANILNIDISKTILLPTRKERYTLLKSPHIYKKHRAQYEIRTHSRLLQLRNITAETSDVFLEYIQRNLPEGISMNIEHTALKQMPDYLQPPPEALEFLKMQRKDSENIPETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZA1</accession>
    <name>A0A6P8HZA1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap guanine nucleotide exchange factor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560616.1">
        <property type="nucleotide sequence ID" value="XM_031704756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZA1"/>
    <dbReference type="FunCoup" id="A0A6P8HZA1">
        <property type="interactions" value="1115"/>
    </dbReference>
    <dbReference type="GeneID" id="116296698"/>
    <dbReference type="KEGG" id="aten:116296698"/>
    <dbReference type="InParanoid" id="A0A6P8HZA1"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF327">
        <property type="entry name" value="EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="207"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="340"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="7">
        <location>
            <begin position="482"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="772"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560616.1"/>
        </source>
    </evidence>
    <sequence length="1011" mass="116601" checksum="6F98970A2BE5CADC" modified="2020-12-02" version="1">MVADWIACLEQRPADRTGEDIDIVYARLKDMKIFERLHPTVLQQICYYGYYQDLEEGIVLFRQGDVGTNWYAILSGTVDVNVSQTGKIEDSVTICTLGPGKVFGESVLDDSPRNATVITSAHCELLMVAKKDFKTIWERSKQYLEGIIFLRTQTTATPNGTQEQDPSVPERSEKNEAKTTNKNSSHSLVHACLVFRRVMETTAPKLLRDRKYNMKEYPKCFVGSEAIDWLLKKSRLVHSRFHALSLWQALLEEGTLAHVTHEYDFRDKTLYYKFLVDEGDEEGYIPLEGEELEDEFEDVLIMLSNVGPDAMFRMALRKDPDKRTQEDLDVIYEELLHIKALSNLSTMVKKDLAAVFVLETCKKKGTMLFNQGDEGNSWYIILKGSVNVLVYGKGVVCQLRDGDDFGKLALVNDAPRTASIETCEDNCQFLKVDKDNFNRILRDVEVNTVRMKERGRDVLVLKQVKIRNHFSDRSPVAKTTQQKYSVMAGTPEKMIEHILEMRIDNKEENKTDSFLLEFLMSYPVFMTSEALCMELLTKYHGSVILDERKDSHDESKSQTSDRSIVVKKRVAQIVIQWHKLAKNLLVEDHSCFLLINDLMSALEADKLFDELNALKKDMNKKKEQDTEVADSQIISCRSLSFSVGFRVGNTNIFERTKRTAGKPISRDDYVIFKVFCADHTYTTVRLKYGDTAQKIVETAEERVLLGDDCVLCEVKSNSEIIPYKPDDMCVVTRLSVNGRLFVAPREHLDSLTPLSEQEGPEQGSFNILEMTSSREIAYHLTVYDYELFTSINIYELVYYTFGRERFDKITANLDLFLKRFNEVHYWVITEICLASQISKRVHLLKKFIKIATHCKEYRNWNSFFAIIMGLNNVAVSRLSQTWEKLPSKFKKMFEEFEASLDPSRNHRVYRLAIGKMKPPIIPFMALLMKDITFINEGNKTYFDDLVNFEKLRMITSTLHLIEYCRSKPFVGEAPPSIKNVNEIVTYVRTLRVNDNQRNLTQLSHRLEPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZD4</accession>
    <name>A0A6P8HZD4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain-containing protein KCTD9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560773.1">
        <property type="nucleotide sequence ID" value="XM_031704913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZD4"/>
    <dbReference type="FunCoup" id="A0A6P8HZD4">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="GeneID" id="116296817"/>
    <dbReference type="KEGG" id="aten:116296817"/>
    <dbReference type="InParanoid" id="A0A6P8HZD4"/>
    <dbReference type="OrthoDB" id="9989223at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18368">
        <property type="entry name" value="BTB_POZ_KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021789">
        <property type="entry name" value="KHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11834">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51490">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KHA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560773.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="45339" checksum="FDE1A494BB38F8E8" modified="2020-12-02" version="1">MASNIPKRAVIYKHGILSEGKLVSVPKTMQELERLVKEKLQLSCVEGIYTSKGGRIDNIELIRDDEVLYIASEKPASNNIDFVPSLLHQQMSKADDLIPKSYSDWVTLNVGGQLFTTTRATLLSKSNSMLAKMFSVTDSWCSIRDPSGAYLIDRSPVYFEPILNYLRHGRVILDEGVNPRGVLEEAKFFGLTSMMEELEETVKKIEKLQDESLSRNEFVRILLSTPSTRELRCQGINLEGADLSNLDLRHINFKLANLSHSDLAGANLSHCSLENANLSYAHLDGAILGNTRFQRANLEGASLRGCNFEDPTGVQAHLEGVNLKASDLEGSQMTNVILRVATLKGANLQNCNLRGAILAGADLENCNLSGCDLQDANLRGANVVGAKFAEILGPLHMSQSVGAYLGRTTTSSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZN4</accession>
    <name>A0A6P8HZN4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116296908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116296908</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560877.1">
        <property type="nucleotide sequence ID" value="XM_031705017.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031560878.1">
        <property type="nucleotide sequence ID" value="XM_031705018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZN4"/>
    <dbReference type="GeneID" id="116296908"/>
    <dbReference type="KEGG" id="aten:116296908"/>
    <dbReference type="OrthoDB" id="5952813at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560878.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22207" checksum="27A2BF585BAE2D34" modified="2020-12-02" version="1">MQELLAPLRNDPTKDPHRRTTSKKNLPVERFWSEVNQRANYPVKSCLNNMVEAGQLRMDDECTKFCVSTFTTHVVQVGINRLIQSWNCRPASGKRKTPIEMMKANNGTANLTEEQVPDGLTAAQIYEGNGGNLTRFGSFGLDPLQGNQELSTQREQLLLQNIASYEAIFNQLVNGNPSLFQRALIYYITLSQSLAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I169</accession>
    <name>A0A6P8I169_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b-245 light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome b(558) alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome b558 subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Neutrophil cytochrome b 22 kDa polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Superoxide-generating NADPH oxidase light chain subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">p22 phagocyte B-cytochrome</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p22-phox</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116297406</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Component of the phagocyte NADPH oxidase core complex/cytochrome b558 complex, composed of CYBB (heavy chain (beta)) and CYBA (light chain (alpha)). Component of the phagocyte NADPH oxidase complex composed of an obligatory core heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic regulatory subunits NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A. Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX4; this interaction mediates superoxide generation. Interacts with calprotectin (S100A8/9). Interacts with GBP7. Interacts with NOXO1. Forms a heterodimer with NOX3 and is essential for activity and cell membrane localization of NOX3. Interacts with NOX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the p22phox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561488.1">
        <property type="nucleotide sequence ID" value="XM_031705628.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I169">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="GeneID" id="116297406"/>
    <dbReference type="KEGG" id="aten:116297406"/>
    <dbReference type="InParanoid" id="A0A6P8I169"/>
    <dbReference type="OrthoDB" id="2445232at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007732">
        <property type="entry name" value="Cyt_b558_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15168:SF0">
        <property type="entry name" value="CYTOCHROME B-245 LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05038">
        <property type="entry name" value="Cytochrom_B558a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031561488.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19721" checksum="AA7586841C05FE3F" modified="2020-12-02" version="1">MGQTEWAMWANEQGVITAFVLVLGGILGVAGDFRLMEIGAYSIALGILVLVVEYPRGKRKKGXKTVERTYQKGFTHLIIALGVIGRNYYVRFVFYLLSCIPCGFFLPTILGAFSLFFTSLIYLRAAVSGETWKPCLEPKAERTSGNNNPSLPPSVPPPRNPRTQSLDNLAYSADSSNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I282</accession>
    <name>A0A6P8I282_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peripheral plasma membrane protein CASK-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558960.1">
        <property type="nucleotide sequence ID" value="XM_031703100.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I282">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="GeneID" id="116295316"/>
    <dbReference type="KEGG" id="aten:116295316"/>
    <dbReference type="InParanoid" id="A0A6P8I282"/>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12035">
        <property type="entry name" value="SH3_MPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000051">
        <property type="entry name" value="Peripheral plasma membrane protein CASK isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="12">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="485"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="572"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="702"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558960.1"/>
        </source>
    </evidence>
    <sequence length="902" mass="101493" checksum="49D94445F33D3390" modified="2020-12-02" version="1">MEKGFPPRFDLQQQIGKGTFSVIKRCIDKKTNKVCAVKIVDVDKMTSSCGLTESDLHREARICQKLKHQHIVELIGGYSMDGFVYMVFEYLDGSDLCFEIVNRVNAGFVFSEAVASHYMRQVLEAVSFCHERGIIHRDLKPHNLLLASKDNSAPLKVADFGVAVELPPEGYILSGRLGTPHFMSPEVIQRQPYGKPVDVWGCGVILFILLGGNFPFHGTGEKVYNSIKKGQPLMKSKQWDHISEEAQEICMQMMKSDPTQRITAEEALSHPWFRSREIPRRDHLQDSVDEMKKFNGRRKLKGAVLAAVASRKFPVVNGDVVGTQSDDDVFECEDDDLTATGAVSQLLDSLEEIKVLTGAKENEXNFLQTFFEDKRLQALLEVYDRSQEWTETHESCPPSTTPTAEQNAKEVIDLIEFRAEEDDDCYELQNVLSDPFVMAMLEAHDGVLTKTNGEGPGMSATDGAPNGYDGPASERPAEKLTRVRLVQFHKNPNEPMGITLKLNDENRCIVSRILHGGMIHRQGTLHPGDEIREINGVNVADKSIETLQAMLKEASGNVTFKIVPSSRGLSTNSDVFVRALFDYDPRSDDLIPCQRAGMAFHCSEIMQVVSKADCYWWQAKKISNDGSDEKFAGLIPSPELQEWRVACIATEKAKKQNGASCVWFSRKKKTYRDRYVAKHNAVFDRLDLVTYEEVVKVDSFKRKSLVLLGAHGVGRRHIKNTLINKFPDRFAYPIPHTTREPRMGEEDGKNYYFVSAEEMIAAIEANKYLEYGTHEGAMYGTKLDTITSIIDRGLVAILDVEPQALKVLRTSKFSPYVVFISAPIMAVEMNDRHDTSSDPNKAEADLSLKRLAKESDTLRQSYGHLFDLTIVNNDIDETINVLEEALENLSQSPQWVPVSWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2A5</accession>
    <name>A0A6P8I2A5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCA1-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031561933.1">
        <property type="nucleotide sequence ID" value="XM_031706073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2A5"/>
    <dbReference type="GeneID" id="116297782"/>
    <dbReference type="KEGG" id="aten:116297782"/>
    <dbReference type="InParanoid" id="A0A6P8I2A5"/>
    <dbReference type="OrthoDB" id="5983041at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12718">
        <property type="entry name" value="RRM_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034932">
        <property type="entry name" value="BRAP2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCA1-associated 2/ETP1 RRM" evidence="1">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561933.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16913" checksum="F1878292D2AAC214" modified="2020-12-02" version="1">MGRIGFFSGNPTVETVKGILHIYKSNEMTSLTKGISRSQTICMFAVPAKLACIDLLQFVAPSEEFIQHIKIIRDATPNQYMALIKFKNQELADEFYNTYNGHQYNSLEEEVCHLVYVAKVEVLKSSQGASLPCSGLTELPKCPVCLERMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2C4</accession>
    <name>A0A6P8I2C4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295351</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559000.1">
        <property type="nucleotide sequence ID" value="XM_031703140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2C4"/>
    <dbReference type="GeneID" id="116295351"/>
    <dbReference type="KEGG" id="aten:116295351"/>
    <dbReference type="InParanoid" id="A0A6P8I2C4"/>
    <dbReference type="OrthoDB" id="10305238at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559000.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25406" checksum="19C3F6EFC892687A" modified="2020-12-02" version="1">MCRSIQGLHISAYIQMIIGIFCIILGFVEIGDEVERYYHKVIAVPFLGFWIGLWFLTGGIVGVLASFYSTTHLKVLIIVYIFVSVTSTFLAGLMTACYYLTIKFWKYQDTHYPAPYGITWVITILGSIELLVSLWACVCSWNIICTSSCCNLDVHSQTEGFQGDFESTSRRTGASSAFVFFEYDNVVPVAASGPNKDPCGTPENIQTEVDSRNEEMPPSYEMAMQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I324</accession>
    <name>A0A6P8I324_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-1 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562233.1">
        <property type="nucleotide sequence ID" value="XM_031706373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I324"/>
    <dbReference type="GeneID" id="116298034"/>
    <dbReference type="KEGG" id="aten:116298034"/>
    <dbReference type="InParanoid" id="A0A6P8I324"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562233.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43725" checksum="5C4C52E075A39107" modified="2020-12-02" version="1">MNNSSVSSNCVNGSCKVGSGNVEQPFKEPTELQVFSLILLGLVILTSLLGNILVIKALLEMIRKPFVYCLVTNLAVSELINTICIPFAVSYLEMGTWVYGDFLCKIMIPMQVTSATVVTTTIAMISIRRFQLVTSRGMNFPSSRKGMWLVILGIWMFGIATSLPLFIFHQVVRVSGPASTDYESLSFCVERYPSDSPYEWPSKTSSRYSIARIFLCFVAPVLIMIISYGAVTVNIKKHIRHIAKSARGRVDSMQSNTRATDCNIDIRASSPPYPQMVPLRDIATRSQEDKTSSPARTEMKALLDQESDLIRMFYIIIFIFIVFYLPFQIFYLLHLLRLVEEGKYGFFIRKYLLLLTCFPSALHPLCYGTKSRFYAKAFKKLILCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I792</accession>
    <name>A0A6P8I792_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tumor protein p63-regulated gene 1-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPRG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563186.1">
        <property type="nucleotide sequence ID" value="XM_031707326.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I792">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116298775"/>
    <dbReference type="InParanoid" id="A0A6P8I792"/>
    <dbReference type="OrthoDB" id="10012704at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040242">
        <property type="entry name" value="TPRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108:SF1">
        <property type="entry name" value="HSAC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="85"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563186.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34425" checksum="33461752843B7DF7" modified="2020-12-02" version="1">MAEGVANDGYHEDLTPSIDSLPPPXYQGSSAMSSEGHSEATSGEVPNVEVRNSPPLYNQTTPLTAQQMQELTEKMKREEAKKYFSLREGQFTNAIEKECKEIINEEEDGKIMSSYLLTEIDHWDHEKERIVMITEKKLVLIRYNFIGLRVDDHRKIPLISCDKIQSGRFTYPKNTMMMLTGYADGNPRLLQHGVRIHFARLEPGLFQNWNPWSQDIPYISLTNHRTYDLTPDPPAHVQIKGFEKALIEAINAARATEASKMSLPNFEVVEEELPITVYLGISAMIVNQSRLGYCKDRGTVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7S4</accession>
    <name>A0A6P8I7S4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylhydrolase ARH1</fullName>
            <ecNumber evidence="4">3.2.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-ribose-L-arginine cleaving enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylarginine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116298878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.19" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031563316.1">
        <property type="nucleotide sequence ID" value="XM_031707456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7S4"/>
    <dbReference type="FunCoup" id="A0A6P8I7S4">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="116298878"/>
    <dbReference type="KEGG" id="aten:116298878"/>
    <dbReference type="InParanoid" id="A0A6P8I7S4"/>
    <dbReference type="OrthoDB" id="5984205at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003875">
        <property type="term" value="F:ADP-ribosylarginine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051725">
        <property type="term" value="P:protein de-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4080.10:FF:000002">
        <property type="entry name" value="ADP-ribosylarginine hydrolase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012108">
        <property type="entry name" value="ADP-ribosylarg_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF26">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016939">
        <property type="entry name" value="ADP_ribslarg_hdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563316.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39305" checksum="6DCF36944D8D771E" modified="2020-12-02" version="1">MLNKFRASMVLSAVGDALGYKNGEWEFCYKGSAIHEELQKLGGLGKIKVDKKNWRISDDTVLHIATAEALISDWSDKHQLFLALAQEYKNGMRDMWGRAPGGTTQASCSKLSPLRPDGYIVPFDTRGGGCGGAMRAMCIGLLYYQPKHLDDLIEVSVESARMTHNHPTGFLGALAASLFTSYALQDKPTREWGAGLMATIPKAMEYIKKTGRDCKENEEHWAYFTDKWNSYLKLRGLEKGDKDPTFPKRYSCGDRDEFYKSVSFSGWGGASGHDAPMIAYDALLGAGNSWEELCHRGMFHGGDSDSTGVMAGAWWGAMHGFEGVPKGNYEKLEYRERLEDLAEKLFKKSESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I872</accession>
    <name>A0A6P8I872_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transient receptor potential cation channel subfamily A member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564754.1">
        <property type="nucleotide sequence ID" value="XM_031708894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I872"/>
    <dbReference type="GeneID" id="116300121"/>
    <dbReference type="KEGG" id="aten:116300121"/>
    <dbReference type="InParanoid" id="A0A6P8I872"/>
    <dbReference type="OrthoDB" id="5986203at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24190:SF14">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24190">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564754.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28794" checksum="E8E0624E68C1D19A" modified="2020-12-02" version="1">MIRKTIKTVLKVLIILLIFLAAFAFAFHVITCSLTDNYSKTRFGNIPTSLAATFFMMLDNLRYEEIVLNYYSNGGDSSKGNGFVLYGLFIAYCFMMPIIFLNLLIGLAVGDIDSIRKTAAMERYTSQVEHLSQLERALPTFILSKAQIMEYVEHPNRPKNLKNKIVDFLVKLLSPRQEQEKKSEDQTNMDQRIARHEAQLKQISSTLKSQSALLEELRDILLDSKKTQLATKLNIETPSSAHTQKSTVSEFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8T9</accession>
    <name>A0A6P8I8T9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxyisourate hydrolase</fullName>
            <ecNumber evidence="2">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031564984.1">
        <property type="nucleotide sequence ID" value="XM_031709124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8T9"/>
    <dbReference type="GeneID" id="116300288"/>
    <dbReference type="KEGG" id="aten:116300288"/>
    <dbReference type="InParanoid" id="A0A6P8I8T9"/>
    <dbReference type="OrthoDB" id="2434995at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF12">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="6">
        <location>
            <begin position="465"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564984.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="65934" checksum="1E45AFF115C08233" modified="2020-12-02" version="1">MADSCNVVLLPSVKIEPVLDEENDLSFETTLESPSCDSQTRFGDTSEEEIQRLLEDKNTANTKKATKTAVNIFREYLREKGLDTCFEDFDKNVLNNVLKKFYVEARKRDGDFYKKSALSSIRFALSRHLQSTRNIDIINDPEFRVSAEVFRAQAVELVRRGKGSIDHFADITPDDLKKLYFSDILNVNSPEGLLRKVFFDLMYLAGSKRSRGTLREQTKDTYGIAEDSEKNLKFIYLKKKSLGLNSYPWKIYEKKGNVRCPVANFAKYLSKLNPLSSFLWQRPKKNVLMEDDVWYENSPLGHNTLGKMMDTMSREARLSKMYSNYCLKGTHASLLNDPTLQNSMLLIKTKLISENGHALPKIVPKPAYSLSAIPCVSIAQPASTMQTVATSNQSLQEEHSFVLSTNDQKQSTPLNTPLTSSIGASSNSHQVILPLTSATSQSQMVGPPVVVSTYGSLYSLAPHPQSKMPGSPLTTHVLDTSSGTPARQLPVKVFYHEEVQNGSSWKVIASGATNGDGRVPNLLTQERFKSGHYKIKFDTETYYKSLAVEEYFYPYVEIVFTIKDPSQHYHVPLLLSPFGYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8W9</accession>
    <name>A0A6P8I8W9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead box protein B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116299928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564513.1">
        <property type="nucleotide sequence ID" value="XM_031708653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8W9"/>
    <dbReference type="GeneID" id="116299928"/>
    <dbReference type="KEGG" id="aten:116299928"/>
    <dbReference type="InParanoid" id="A0A6P8I8W9"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000071">
        <property type="entry name" value="Forkhead box F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF387">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="101"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="101"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564513.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36685" checksum="D6BEEAE7B99035A5" modified="2020-12-02" version="1">MERLTGNAFSSFGFEKLRMEGSKGLATGNEFKDNIPQHSAAISEERIHEQIPLVYHGEPRVPAYYCPYNPAIKPNDNIQDELFNMNGVSHQSKPYLTDEVKPPFSYIALITMSIQSSPYRMRTLNEIYEFIMTRFPYFRKNQQKWQNSIRHNLSLNDCFVKVPRSIFGKPGKGNYWTLHPSCGDMFGSGSFLRRPKRFKCRIPQSSNEPAHISKVDSYHHFSLYGGSSWPYVATSQPLVSPRQISHLYGVTNRADVRQIELKYSPSVVRPRACYPVEEYHHQHTTKSKTRGFFIQDLMESSSELRDRDSDYENEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I967</accession>
    <name>A0A6P8I967_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoskeleton-associated protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CKAP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561652.1">
        <property type="nucleotide sequence ID" value="XM_031705792.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I967">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="GeneID" id="116297546"/>
    <dbReference type="KEGG" id="aten:116297546"/>
    <dbReference type="InParanoid" id="A0A6P8I967"/>
    <dbReference type="OrthoDB" id="6288182at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052855">
        <property type="entry name" value="CKAP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029197">
        <property type="entry name" value="CKAP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47078">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47078:SF1">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15297">
        <property type="entry name" value="CKAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytoskeleton-associated protein 2 C-terminal" evidence="7">
        <location>
            <begin position="292"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561652.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="66020" checksum="C96D93BD76562850" modified="2020-12-02" version="1">MADRRVLTLSQQPSKTQESMRSKLEEWRKVRQQQTAKQLKQQTVPLKTPNRVKPQVSQQKAKSVQPKSKETSLSKSSLAHRKRKSFHVLLYDTAGVKKITDENTAEESCQTVNIELNINEIKRRNSKIQKPPETFEIESAPDSKRARRSTFTIETPMKEVGDKNKENPKRCEKNEQNLRNKLEIWRENKRKKQATPTIPKSLKLHIKPQNSCNRKDGSNSGXNCVKTMDPGKCNQVCTAKKFPKKNGPPTQPQKVSQITKSKVGPKDTVNLPRTPLKLLLPHMDKTLSMRERLELWRKEKGKTEGVTKTPATLRRKSTMPSRRKDHKPITMETQEPLQLEPFDTMHCDMAEKKPTPEEIRQKLQNCLEKIKEDKNNDDMIANHLDEIQDAHPGSLQCAEFWICRAKIAEHEEDDGRVVCLFEQALVFNAEPEHLIKEAVAEYSKTRKGQKEVSSIEVPEAVPGLSVTPPRVDDILNKQAGQPSPFDSSIIKYSVTKATPFKSRLKSCERPVVTPVRRSTRLERRSMHYPTTLQEHGLAVRHLDDLPEDIKKNVLFKPNLTVQNDLNEAWKALWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9I4</accession>
    <name>A0A6P8I9I4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sentrin-specific protease 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116297664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561797.1">
        <property type="nucleotide sequence ID" value="XM_031705937.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I9I4">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="GeneID" id="116297664"/>
    <dbReference type="KEGG" id="aten:116297664"/>
    <dbReference type="InParanoid" id="A0A6P8I9I4"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031561797.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24722" checksum="7247EA0752565950" modified="2020-12-02" version="1">MADKKEKDKIVLSFHDSLLHNSDVLLLNEGXWLNDNLIGFMFEYFEYEQFKGASEKXVFISPDVTQFIKLGDGPEVGIFLDPLNLPKHKLLFFVINDHESKTSTGGSHWSLLCYNRDRNSFIHYDSFHGNNNDAAKSIAKNIQPYLSAVDVPSFVNGKCPQQQNGCDCGLYVISITEHLCKEYLGLTSTPLTDTVNASSVSEKRQYIKNLILQLVSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA93</accession>
    <name>A0A6P8IA93_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein ceh-12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562112.1">
        <property type="nucleotide sequence ID" value="XM_031706252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IA93"/>
    <dbReference type="GeneID" id="116297927"/>
    <dbReference type="KEGG" id="aten:116297927"/>
    <dbReference type="InParanoid" id="A0A6P8IA93"/>
    <dbReference type="OrthoDB" id="5971575at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031562112.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29707" checksum="820937720F58671B" modified="2020-12-02" version="1">MASDNRATRSPSTAPSKSSFSIDNILNIQNSGTQEARKFDIFPQGFSNVPPLAAVPSLLPTALRPSLMDFSITQMLPPLPFQNPLNLEDFHMAAAHPFPTFPFNLSYPRQGIPMSMNPFLKRRKRFMRKPKQRPLFAHSQIERLEKEFGKEKYLTEAKRGELSKDLGMTETQVKTWYQNRRTKWRKEIKEKMNPEGRNEENRQKEERGSHVWEDSMLNGYECMPHSLNTSGSFSSKLQEMRTFVDLETIKPRFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAN3</accession>
    <name>A0A6P8IAN3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565223.1">
        <property type="nucleotide sequence ID" value="XM_031709363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAN3"/>
    <dbReference type="GeneID" id="116300486"/>
    <dbReference type="KEGG" id="aten:116300486"/>
    <dbReference type="InParanoid" id="A0A6P8IAN3"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565223.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18003" checksum="54AFB9620D1F3BBE" modified="2020-12-02" version="1">MAAASRNVLLPVDGSDQSRKAFEWYCTHLYHEGDTAIFLNVYILPEMYDASLTWPAVKDVAEDWNYNQHVKEKEADELLQRYEKKCKENCFSSKSNKIPLSFGDAGKVAEKICDFSVEEKADIIVMNHHGDKTEGEELGSTCSYCVKNAKIPVCVLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAN6</accession>
    <name>A0A6P8IAN6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300492</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565228.1">
        <property type="nucleotide sequence ID" value="XM_031709368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAN6"/>
    <dbReference type="GeneID" id="116300492"/>
    <dbReference type="KEGG" id="aten:116300492"/>
    <dbReference type="InParanoid" id="A0A6P8IAN6"/>
    <dbReference type="OrthoDB" id="10276217at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="92"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565228.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29996" checksum="D9395E32FF6CFFB4" modified="2020-12-02" version="1">MSSASLKDHSKAKGGVFNVKVYNGGNAICGPGATATISRKYHKSSCSAHRHNKAISYPLGDDYNKSELLQGPEQRLTDVPAKVYQELEKQLSFGQSDWKNLACHIFPSLKQDEIEYLTTRYRRNRAEGIFKKMSERGITLGQLVKGLESIERQDALEILFEAGYPRESDTIAENDESVMEACSRIQEEAIDEEREEVPQENVCFEKNSYRVFIEEPTLKGVIGSADGSSTSFVRNLMSRVCLVQFPTTPEERFTSAVSMFEEIQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBU5</accession>
    <name>A0A6P8IBU5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain collagen C4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562345.1">
        <property type="nucleotide sequence ID" value="XM_031706485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298118"/>
    <dbReference type="KEGG" id="aten:116298118"/>
    <dbReference type="InParanoid" id="A0A6P8IBU5"/>
    <dbReference type="OrthoDB" id="6127486at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027754188" evidence="2">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562345.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32408" checksum="47E1B2E3B21DDD31" modified="2020-12-02" version="1">MLSKAVLLVVAVSIALLLVVVTANEKKEQGVEKRATVPIQTPTTLADMAKVLVEIQKRMNAVESSRTILLRGRDGRDGLPGRPGRDGRNCGLPGRPGPPGLKGETGHQGVRGLPGPNGGGVQYVRWGRTTCPYGASLVYKGRIGGEYYSHKGGGANYVCLPETPKYGRYKDGHQHAGYMYGTEYEVNAFNPLTTSNLHDHEAPCAVCYXTTRSTKMMIPATYECPVGWTREYRGYLMTQYHSFGKSEFICVDQDAEAVLGSQRNSEGALLYPVEGRCGSLPCLPYVDGRELTCVVCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBV4</accession>
    <name>A0A6P8IBV4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YER152C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564871.1">
        <property type="nucleotide sequence ID" value="XM_031709011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBV4"/>
    <dbReference type="FunCoup" id="A0A6P8IBV4">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="GeneID" id="116300198"/>
    <dbReference type="KEGG" id="aten:116300198"/>
    <dbReference type="InParanoid" id="A0A6P8IBV4"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="13"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564871.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45417" checksum="75C202E513D3534A" modified="2020-12-02" version="1">MAHLFSHIDEQGLVGLGVGAPDKSLLKKTADVMLQGTKALLESGDVDCLQYGPRRGDSEMLKELAKFLSDEYQDEVKSENLMINAGATQGLKFLSKSLFDPGDLALFEDPTYFIAITVLVKDIGLKPMAVSTDEDGINVDEVDKILTEHVAGKTLTSNKPYSALVYLVPTFNNPKGTILSEEKSKKLIKVLRKHKAIAICDDVYNTLSFIDERPPLVTPPPKRLFAYDNEADADYQGNVVSNCTFSKTLGPGLRLGWVEAPPHLLTILESSGYVLSGGCFNHYTSCVIREALKLGLISKLVVEVREVYQSRKNALCDAIDKFLPMAQYLRPKGGYFVWVILPENINTNDLFTICKEKYRVLFRPGTLCSCVGNFPNCLRLSFSYYSEEILSEAVRKIRMAIDDLLNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBY8</accession>
    <name>A0A6P8IBY8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase I subunit RPA43</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-directed RNA polymerase I subunit F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Twist neighbor protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116298728</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563127.1">
        <property type="nucleotide sequence ID" value="XM_031707267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBY8"/>
    <dbReference type="FunCoup" id="A0A6P8IBY8">
        <property type="interactions" value="1395"/>
    </dbReference>
    <dbReference type="GeneID" id="116298728"/>
    <dbReference type="KEGG" id="aten:116298728"/>
    <dbReference type="InParanoid" id="A0A6P8IBY8"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase I subunit RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="12">
        <location>
            <begin position="102"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031563127.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31688" checksum="2C800A34D0A4C520" modified="2020-12-02" version="1">MAAEGTGHLSLTEARRKCEEKYSCFTKIECTECMSLSPSYIGRLKEGIEEELSKKLMKFCEKLQGVIVAYDKIQLLRRHGSIVEESPFIHFEVKVNYIVFQPQVDSKLIGVVNKFGYDHIGCLVHGCFNASISNPRTQNGHFTDNLKLGSSFTFRVVGLESLNGVLLITGAFDDKTLRKKSKSKKSLDRDKNSDPTTEGTEIQTSKKSKKHKQENDSETEGPVAKKKKKLSNGDARRDEEVSANKNNNNEKNFKIKSEKTSNDDHISSLKKAKKKKKNHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICL1</accession>
    <name>A0A6P8ICL1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripartite motif-containing protein 45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565341.1">
        <property type="nucleotide sequence ID" value="XM_031709481.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116300592"/>
    <dbReference type="InParanoid" id="A0A6P8ICL1"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="211"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="10">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565341.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="53726" checksum="66DCB94A50CE13DC" modified="2020-12-02" version="1">MAAKLSERLGEQVTCPICLEHFSDPRLLPCLHTYCRQCLQDLLAKGKRKVSVICPECREEVQIISGDVTKLQVNFWINNLLSLLSIHSTDEKDGGNTELTCENCDSKAAAKGRCVNCCMFLCNVCFTXHQRLLALKDHQLITLDELKDTGIPVIEKQLFCEKHKGEVKKLFCNTCXEVICRDCTIXDHRDHQFSFVEDVXDQXKQLFKTEVQRASNTKNKIEAXLKSVEKMKENVEEXTKATEENIDNXIDKQIXALEEKRASLKETTKKIAATKXKELXAQEDGLTMHLTGLKSAIEFTEKVLXNGGSSDVLSLSKQLTSRLSQLSEKPYPEDLCIPWQKAITRLEFNEXLFLKSINCVKIVDVTPVDYSKCSVGQLIDGHLVDIKGNIRARGGQVLEFVVQIKNSFGEKMKIMPDRIKATARFGESMVLPIRRLEDDTYSFKLTLIPTFIMIWSKILVMVDGKNILGSPINIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDK9</accession>
    <name>A0A6P8IDK9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory subunit 27-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564372.1">
        <property type="nucleotide sequence ID" value="XM_031708512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299803"/>
    <dbReference type="KEGG" id="aten:116299803"/>
    <dbReference type="InParanoid" id="A0A6P8IDK9"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053080">
        <property type="entry name" value="PP1_regulatory_subunit_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46899">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46899:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564372.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16314" checksum="71CDAEE97D2B0361" modified="2020-12-02" version="1">MDRRVKFPHELVFHDMVKDGDSSEMSHFLKRPSVDPQGIINSRGDQSGPALHQLVKDGNLKCVRVLVNLGADVNMQDDXGFRPLHHCAYTGNFDMAKFLMKRGANPDLTDHQGRTPVDLTEDFDMIELLMMYSPEERRKSMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDN4</accession>
    <name>A0A6P8IDN4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116299136</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1&lt;-&gt;1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:189081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>UDP-alpha-D-xylose + an N-acylsphing-4-enine = a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70244"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031563630.1">
        <property type="nucleotide sequence ID" value="XM_031707770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDN4"/>
    <dbReference type="FunCoup" id="A0A6P8IDN4">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="GeneID" id="116299136"/>
    <dbReference type="KEGG" id="aten:116299136"/>
    <dbReference type="InParanoid" id="A0A6P8IDN4"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000041">
        <property type="entry name" value="UDP-glucose ceramide glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031563630.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47818" checksum="A0C0CBF99304E445" modified="2020-12-02" version="1">MDKMVLFIRELYMPTFFTALACFFFFLWVALFVLHLIAITGGKLLLYKSTSAVNEKELPEVSILKPLAGEDSHLIKNLKTFFELNYPKYEILFCVQDEHDTAVPVVQQLMKSYPLVDAKLYAESRTVGVNPKINNMNQGYKAAKYKLLWICDSAIQVHQKTLLEMVSHIGPKVGMVHQIPYITCSPTASFAACVDQVYFGTQHAFLYLFANTVGLVCANGMSTLYDKTVLDELGGLEAFSCYIAEDYFMSKAIHAKGYKIAFSSEPAMQNPRKQSLEIFQKRMLRWTRLRLAMEPFPSYLEPFTESIVIGILATWSVWHLWGMNIILFFIEHLILTFFFDYLLLRIVHGAHLRGPLPPLWKVFLAWLFREFFCLVFFFQAAFGRQIEWRTTQFRLLNGGKAELVNKCKDINSHCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFM0</accession>
    <name>A0A6P8IFM0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116300707</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031565483.1">
        <property type="nucleotide sequence ID" value="XM_031709623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFM0"/>
    <dbReference type="GeneID" id="116300707"/>
    <dbReference type="KEGG" id="aten:116300707"/>
    <dbReference type="InParanoid" id="A0A6P8IFM0"/>
    <dbReference type="OrthoDB" id="5980066at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058390">
        <property type="entry name" value="DUF8077"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26284">
        <property type="entry name" value="DUF8077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8077" evidence="2">
        <location>
            <begin position="53"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565483.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24660" checksum="9ABDF90FB6A9599F" modified="2020-12-02" version="1">MLQSFSGNVFHVLYVYLIIWTFAVPTKSDDAKENTAIVAFRDVTISSWSSDDKTAKFKDVIAAVANDYCSSNYDNCALRFWNTTRTFRNSDVTIASNYPKQVETDIEIQFYVVLPSGNDIRKPNSTVLPKGTLDGILEANSTQIGAAVNAQVKNTADGSTTKPKTDNAMDSIMIPVGFGLLIFVIILACCLHYCHKKKLEQIKKEERRQFLLKQKSEGSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGM9</accession>
    <name>A0A6P8IGM9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301014</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565871.1">
        <property type="nucleotide sequence ID" value="XM_031710011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301014"/>
    <dbReference type="KEGG" id="aten:116301014"/>
    <dbReference type="InParanoid" id="A0A6P8IGM9"/>
    <dbReference type="OrthoDB" id="5959066at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565871.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37404" checksum="549CB63E538B2A56" modified="2020-12-02" version="1">MNLDTVLSKRPFDQTTHVQQALRRLKYLHTSLANPKASSLKPLQTTSTPPPINRLDLPGDEEKDNFEDQNAVDKRCFLALTPKEFKEEDLRRNNLISRQRCGWRPVRKGRAPLTSPTAYFNPTFHPLSTRTESPWDRKTRRETSQRKXSPNSKDRKAKSAPASGGLPSLNPEQFDCVQCFANEMERLQQTEGPEFNTNFKINRMTFSARPKPKESQNKYSPVSNKFISEKTFNIPQSTYGGWGVRSRRRNTDATHKNSRDKRGSELDVTSEFQTLRIEPQGTSEGWGTARVAXETLSPPPPAPPTPIQQIDIKMPEGYLVKYRLQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH25</accession>
    <name>A0A6P8IH25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116301174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116301174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566056.1">
        <property type="nucleotide sequence ID" value="XM_031710196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH25"/>
    <dbReference type="GeneID" id="116301174"/>
    <dbReference type="KEGG" id="aten:116301174"/>
    <dbReference type="InParanoid" id="A0A6P8IH25"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031566056.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12176" checksum="FBA6FE0EE2247B4D" modified="2020-12-02" version="1">MASGFARKLCGRRQDEEPDEVVPLRFEEEMRAQQKARLQPETRVQREQKDDLFDAIRRCDLEHIKKLKERFSFKDIRDNVSNVSNTSCCILLGFQNSSGISNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHH1</accession>
    <name>A0A6P8IHH1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melatonin receptor type 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566277.1">
        <property type="nucleotide sequence ID" value="XM_031710417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHH1"/>
    <dbReference type="FunCoup" id="A0A6P8IHH1">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="GeneID" id="116301373"/>
    <dbReference type="KEGG" id="aten:116301373"/>
    <dbReference type="InParanoid" id="A0A6P8IHH1"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566277.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39152" checksum="B7C2F4AC6DB31618" modified="2020-12-02" version="1">MMSHLPSINSSSLKSLRSRAPALVITETSIYTSISIAALLGNSLVLWIVYKNRALRTIPNYFVISLACTDISMALLGTPWSIVVLATGSWPSNFAGCQVQGYVVILVAIASLQNLMIMAFNRYCRIVNQSLYRKVFTKNRTRLLIFLAYIIAAISALPYIIGGQFYVFQPGKFFCYQKSMVEYTIPLMLIFIGTPTVIILICYLKVFFALRNHQKNLHKPESERGSKFQRITVEEIRITRTLFATIVGYLLCWMPVLFIEIIDLGLGEGSLPRQVYMMFTMCGLSSSAINPVIYGVMNKTFRREYKKAFKCGASNTVQPRQSNSKTRPVNTINKLYQKTKLNETET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II58</accession>
    <name>A0A6P8II58_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116301551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116301551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566487.1">
        <property type="nucleotide sequence ID" value="XM_031710627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8II58"/>
    <dbReference type="GeneID" id="116301551"/>
    <dbReference type="KEGG" id="aten:116301551"/>
    <dbReference type="InParanoid" id="A0A6P8II58"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF32">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028387479" evidence="2">
        <location>
            <begin position="21"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031566487.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52144" checksum="527D20FF69C9DA2E" modified="2020-12-02" version="1">MESLLTLFFLFVVVFSSIDGQESTEEKNSEGRRVLVFGGNGFIGSEVVKELIEKGYDITLVNRGNWYFDSKERIQPYVNYHFTCDRDKAFKLECPELLTSGYYDIVIDFSSYTSKQIQQVTDILRDRVGLYIYISTDSIYEVCQKDHVAASREEDAVRPKSAKKRMQLRKSETYGHEKLACEEVLRKQRQAGGFPYVALRLPDVIGPRDGSFRFWTYQIWIQTHKAIKEKVHLPLGVSDTKFSLIHVEDAAKAVQKIIEAGPKAYDLAINFAFEEYFTLKSLLTDIGRQLKVEDIDFLTDEDQAWYTYPTVTKGPLDISRARLLLDWEPIPWTRALKSLTTFFEDAMTDKAFASEREMVLADVIENLVPEEKYSSFLKALKRIYGEDVFDGLDMDIGFAKDAMELEGSSVNNTSDAHTIASNGQNSTTTADEVVHDDEEMESTDTAKSTKNAEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK86</accession>
    <name>A0A6P8IK86_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116302243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567336.1">
        <property type="nucleotide sequence ID" value="XM_031711476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302243"/>
    <dbReference type="KEGG" id="aten:116302243"/>
    <dbReference type="InParanoid" id="A0A6P8IK86"/>
    <dbReference type="OrthoDB" id="9975373at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469:SF0">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567336.1"/>
        </source>
    </evidence>
    <sequence length="971" mass="107866" checksum="99071F7E8D678686" modified="2020-12-02" version="1">MEVFTSEDVSKIFWKKLVVVIGDSIQRCVYKDLVCLLSPGSNTRYLTSKELKAKGEIDFLNDKLLQGGQLGEVKTGINYREVRQYDNGTSVVKFYFATRCYSDHLESVLNELKTMQPHAVIMNSCLWDLHRYGPRGPDSYHVNMKKLMVGLKKVIPSDAVFIWNATLPLDSKCKGGFLLPYYENIPAQEIIEANFIAADIVRSYGFIFLDLHSLFVHQLYHXAKDGIHWNHFAHRRISNLILLHLCRAWNLPVPKTMPLDIPREPRLQPLAERPRNASFGSYTSELHIDRYGFNSSGDARYVVQKPNTYKDRFRLMGSPIIIXSTTVSKDNQMPSPVIPGLTSDVNKESEPFAKPIYASSPMETVSMTKSLLQQNESTTTLDSPLTEQYIDQKLGLSQNLEQDFNACSGASKNSTSYFSDTNGTQTNEGGENTLTGKGXTSTASQSSSLVIQVXSTCIAXKEKDSVVEIQPTTCTSSINPALSSHXHVSQMNLPVLPVTSQVTMMNPSPVTKXTSYYDKXSNVXAPSNKVALPTSHRSQLTIPVNQVASSQVAKTTASINQHNAICASVYIPPASLAGHXPSLSTPVMSSVTKTTQCLGKENALCTTGNSIPLLANVSQLRKYDLPNKKQACSRITTVHAPQRTSNIPVIINQEASTLNTQIQKELHVVKSSVDSVVQTKEQLRVGGSTVDXNKPSKINDVFESSKVQNKTKHPVPSTKRKAPVKDLEHKASMDVQPKKQKLAESALSNTSGKSHSEAKKSFSGRASSTKLSEVSSGGQKRKTTGDEASSRITKQHKVSEVKKKADDSRKPSGNLKRKAPTEAAANENKNLPHHDLKPPPVKRGKNERDSSTTSRQYPMRNALPLSGQHSTSSSTCHASIPVYSGNRIETNAPPQRQCVPSYNFVQSNCYWTESQQSLQDIQQQQQWFNTLLSRGRAGPYMNNAQPLFYYNHYTRSWQINQGYYYSNNYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKN9</accession>
    <name>A0A6P8IKN9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Transient receptor potential cation channel subfamily A member 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116302382</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567521.1">
        <property type="nucleotide sequence ID" value="XM_031711661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567522.1">
        <property type="nucleotide sequence ID" value="XM_031711662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKN9"/>
    <dbReference type="GeneID" id="116302382"/>
    <dbReference type="KEGG" id="aten:116302382"/>
    <dbReference type="OrthoDB" id="1661883at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031567521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031567522.1"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120382" checksum="31FAFB83C48F1968" modified="2020-12-02" version="1">MGKKDTKKKKEKDVPLVIVNDANKEKDFQDEDDAEEKVEEKPQEIKKQGTKQEQLCSAAYTGDKEGVEKLLDKGVDINYRDEYGKSPLHHATSGKHHNIVELLLGRGADVTLQDQRGDTPLHAAVRAGDEPSVKCLLTQERCNVSAEGRGLCSPLHIACGMDRLAISKVLVEHNASIDCKDEDQMTPLGHAVEKGAKNTAAYLFKIVKSKLGSAESLLYNADSEGSTLLHMAVDSGITDIVELCLSNGARVREPKRTDKTTAFHLACSQGPVEMVRLLTKQDPAICRICLIDKGGMSGLHRAATNNQRDIVEFLLDQGASVDLPDKARRTPLFMAASSGATETVELLIKRGANITAKNLAMKSVLHSAVGHDNTIDAILKSPAASYLISEKDKNGFAPIHQAAMGGHLQNIHLFMTKNKAAAGITSDSLDTPLHVACRYGWLEIVKDLLVGRNVRMINLQNNQGKTPLHFAAGEGHEKVVELLVERGATVERDELERTPLHLAAINGSSRCVDCILGKHPDCLNFVDDDQNTALNLAALHGHEELVEDLLSRSNQQILMNNFNQNALDIAIRMEKKDVAMTIADHDRWRELMNTSSPGGLGQMKVLLIKMPDVAERILDRCVIKEGDPIKQDYKITYDFSFIQGKINSKQDPLGVLRTMAAKRHDKCMVHQVIFKLMDRKWLTYGWISLSIIIFLYLCYLIPLTILAVHLKQNEVVMCQFNESNPKLEHDQSELIYSLQDKASLYLHYCVIAMTAFHALREFLQMYNNRLLYFTSLSNYLEWTGYIFTFLYVIPPYDCKWGIHQRFGAVSLFFSWTNLILYFRKLSFYGQYVIMLSTMFVTLFKVLMLFFLFVMAFGTTFYLLLDNVDSFLRLEYSLMTMFVMTLGEMNYADTFMPWKNLPHPTLTNILFLVFALGMPIILMNMLVGLAVGDIDGIMKNAAMDRYVTQIEMLLDTEDTLPLRIRRGLKFDKVEEYPNRKLSLKTKIYHWIFGFTHPGEDEVEDDEIQDDPMEVIKNKLEDQENRIEQIYELLQLQTQALVKMDKDGAFNVESTQKPQKKGFFSGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILG1</accession>
    <name>A0A6P8ILG1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567644.1">
        <property type="nucleotide sequence ID" value="XM_031711784.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116302485"/>
    <dbReference type="InParanoid" id="A0A6P8ILG1"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2753"/>
            <end position="2835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="845"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2059"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2129"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2433"/>
            <end position="2726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2756"/>
            <end position="2771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2788"/>
            <end position="2799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2810"/>
            <end position="2819"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567644.1"/>
        </source>
    </evidence>
    <sequence length="2835" mass="327672" checksum="4AE1A733EE6DB569" modified="2020-12-02" version="1">MNDSELSSSXSSSRMETSSTNYGAGSGSSSYYKSLKTYSSXAGGHGAGDITLQQISEAKEVFGDMEAAYRRFKYEIEEVRKEHAIEVRKLQLEIENLKRQKRVLEDQLRESKGDNKKLSDELAMVRRRLMDKETENEMLKRELSKKNNEIASLRADKLDLQKRIESMSQEMIISSDSTTIVQSAPDEDDLYLAHQEISAYETTIKSSSEEKEALRDEIASLSARLSRLQGDYDKAMRDLEASKRDSDLKARKYEASLQNAQRQRDDLKDKLERLRDELKRTKESINEYRTDALNNKKAADRLRDEVGSKDKQIRXLEXKNXDLEDRLEXLXXEXXQAQMKAEIETKTRQNMERDLRNAEKKVAELEATVESLKTENGDLQRELSITLKKLAAAENELSKATSRIKQLEVEVTRYRSRVRELETEIENISSTHVQLQSTYESSVSEVDGLLSRLGGTSAKVNDLESLYEITAKERDELKQNIAPLEKRISDLKIALERSENTRDDLERQVEALRSKNTNLEAMLEAAQKAKVQLKSDLDAEKDRVSKLRKXIVDLQAALADAQRTAEKYKNDNDRKKKTIDDLKNTIRQLEDRINALDNEVQEVNTKNDILEEQAKEMQGDLNDANKRAQIAEDEAKHLEDEVERLNKELQDRDKQISELESAYDTAEKEKRDFEQQVLALNQKVNRLEKELQDALNKNAVLEEDAKNHQSVVDKLQDEVDRLKNKLNDAVRRADEATKDSLEKDANIEDLKNQISALEKEVEELRADLIHTKSLLQSSEDEKRKLLIELKKKEEECNRLITDIEKHTQRINVLEGECMVVNSQIENVQSSYTDFMDSSSGMEGLLESEKEKVALLEKELLGLRNKVQSFDERDALKQKEIDRLKAELEAADEKIADLLKEVQRLEGEKDEINRNLLVAQSKVNELESDLEAAVEDRKKAEDDLYDLQTKIGKLENQIDTLRKQNQQLKDQLKDANNKLVPAKERIAILEAENTQQKKQNDALNNVITKKDKVISELNNKIKKLQKDLEDAKRDVLAANVSADAAREEKKELERKNKVLADRIEQLEREIKDLKEQRNALDNELSSKNHKLALLEGQLASVRKERDNLKIELDNLNAAFRKLKEDYLTVLSDLKAREREVESKDKIIKEKDVMIERLRNGKAASDEELAKLRKELMNTKNELESTLSKLKTLEETYKNTNLNLSKLEITISNLNKERQERDSVSSTHDTRYYEIETLYKASQDRENRFKQELQSYKNRYERLEADYQKLQKENVDLRAMVNSLNKKIRDLEAFKNRIEKEKQALKAELLKVNNELADLEVQMDSTMKENESLNNQLQDAQDRLEKARNDNLDLQQKNVELKMEVEALEREATEKDNTINSLTASKEYIEGQLDSLKKQLAAMKDENDNLKEEKASLQQEILDLTNKINELENLLARISGERDRLLEDLRTSANKINILEQQIRDLQKDKEGLNDKIEDLKRQLNALREEKNLIERELNDLKSKIDYYIKEIDGRDRTIEEMKNRCDELERELDSLKKNMRRLEADYEAAQQKIRDLEKSHSSVTDRLTIIENAGDGHRDKARRLEEENINLKRRVAEMDIANKVSSEKEFDLQQKLSQANEQIINIESQRPVESGITMMSEVVVESSQDDMEVEMLRSDLESLKTKYNKLERQNKSLTDANAKLQAELGNRDKKIKDLEDEILDLKRVIQELKTKLAQMGDQTDAPGIIASLRTQKNNLERDNNMHIQELNSLRAQLVESKKRKDDLEAELQKLRRELGDVKLKLQITITENDNLNAELINAQKKIASLEEDYHRSMQEIAKLRGELDETRVQLSRAKEDMFEAQRAASDLALQVDALRREIADKNNQLQWHENNEKQLQNEIFDLKQKIAKLQERIDEYADQVTLLNTKVHEKETKIAELEHFLNLARDENDRLRKELATANANATDFKNKYLNALKDIERLQNELNVKNQKIFYLENRVKTLEADKNRFKMEINSLKKTISQLRIEIETHRQEKDRLHGDLVIVSNQASEVQSAPPSGMSIDIDISTSKRYKDLDGAYKKLKMSKELLDNEMVSLRKRLTKTENDLSNANREKNILDGQSAWKDKRIKEMEEALNELQSKDRVDADEALEWKKRNAQLEQEVQNLKNKVTRLETYNETFENKIKDLTDEIVNARHKIAQLEAQSDEAQRNIEAQQKELLDAYKKIAELEAALQSAQNAKGELQRDKQNLQNKINALEDELQNEAKTQAQLRGILDQNKTRNEALKAEIAKLQQKLRDLQQNFDAQVAEHAERKYTVDRLEDEIKNLLADNDKQRKEIAMLRNELENLMSEKRDLQGDLLRAEPQITDLTTQLHNSRDENSRLKIEIETLRNQLQEARSRYEKVETETVIREAAGGQLESGVDMFASMDDDVDGLRAEKDRLASDATSWQNKFNTLQKNFDDISIEKQRLEERLATMQKTINHLENTNQGLSNDKNKLFHDFETSKRKISDLQNDLDNCRFGKDQLQAENDVLLKRVAQLEAEIDIQSKSNIEDYDDSSSYAVLQAAYKRSQERENELQAELLNAYKMNAKLDNENKTLHEKFAALEIKNKNLILKSDALKDDIITLQKKLSEIEEKYDLTRERNEELEDELTVLQHRMGEIDNDNKFNQQGKAEYQVEITKLQNKLSRVETALEDCNRGKESQLSQISMLRSKADAQVEDLLNQLKDCKSRCESYRYQVDNLQRQLTMSSIQSSSVSTTMSSPQVTVTRRKYIATDSSGGSPSRTSYTTRTEAKGAGSGGGDVSGSTEKSLQDFFSSDTPKEESTGLEFSDDDDDEPEVTTKRVVVKSARTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILJ3</accession>
    <name>A0A6P8ILJ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protocadherin Fat 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116302394</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567535.1">
        <property type="nucleotide sequence ID" value="XM_031711675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILJ3"/>
    <dbReference type="GeneID" id="116302394"/>
    <dbReference type="KEGG" id="aten:116302394"/>
    <dbReference type="InParanoid" id="A0A6P8ILJ3"/>
    <dbReference type="OrthoDB" id="5952955at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000021">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="164"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="273"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="373"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="478"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="597"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="706"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="813"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1158"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031567535.1"/>
        </source>
    </evidence>
    <sequence length="1221" mass="138043" checksum="69BE2E81ADB670E6" modified="2020-12-02" version="1">MLIPTNDFWKAKHRKFGFEKLTLSSRKIFAPRKKLVKMFSPPEILNTLLFLFCSLFLLSECSIINDPRSTIICMPGDTIHNVTLTHGINAGVFTAIDWAKTMPQCIRESCNRKAGQIAFLVESSCYMVSCFRKEYCKSFSDSMPNTLRVAVTPYTFFDAAPAFQPLERTLYIDENNKVGKKLIDIFAYAKSRRSDNATVFFNITRGNIANAFKLIQRPERGGASLVANVVLDRENVSYYYLIIQATNVDEQKISTTTLRVEVLDINDNGPKFLKSQYSTTINSNVSIGTEVLRVYAVDPDTGENAQIRYYLITYTQLFQILPETGTIIVKQRIQLDRTRTFTLIVAAINGEHRAVVSVNVQVVALNEFRPFFQRLNYQVSVSEAIKVGTSLIRISATDSDTGSFSQLKYSITSGNNNLFRIDDSGDVRTTKSLHSIGVKNFTLRISVRDSGNPPLKSVQSAKLVVLVTSMERYKVKFDVPLYTIAIMENIPVGSSILNVRAVSGLSASRPGRQKENRKGRIVYSIENKDGAPFFRISKHTGAISTRRPFDYELQKEFRLTVNAKDIEARRRGLRVQKDHAIVRVKVIDLNDNRPKFVLSFYQDIINENMTVGSSILRVTANDADNGMNKKVEYIMQSGNINNTFSMDADSGTLRLSRSLAQGTIEFYNLTVFAKDKGRPPLSSSPVSIYIKVKRHTFGPTIRPEFTVPVYLAKVNESCPVHTEILRVRARMNSGPDSGIKYYATQVSGGEADSHFAVNSVTGAITLIRKLDYKKKDRYTFLVAAIDVSKASSVDNVLVRILVEDVNNHKPVFDKPVYNVIYNKEPQLFSRVVQVTATDEDAGQNADLTYFLHDNAKDKKGFFEIEPKTGIMKIMRMLQRESLSLFRMSVSVIDNGTPSLRSDKNAEINVLIFQPFSTPLILIKTTQQTITVQFNLKYLDLTNVKEFGVIVQEYLPSSDLFEDYTKLKPTTWFLIGYLQKKNQNLRRYISKIVPNTPVITKFGMFQITVGDDKGCNLRNEICSGPLNPSSKYRFQLRAYLNDSGPFAQHKFKDGDFTEAFFTGLGTEAKTYRKEGRRNYDAVVYSVGAALILVILLSFLRGFYRLKLDRLRIHEDKKKQISFPVSNPRFQDPESPVEKIRTPGQGRKLMASINAEKSLDIGRSEEDDGSSPDSALDESTRPLQRQRPRLQDIRLKSYFHSVDTESCNSCDGVKVYYVQESNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILT0</accession>
    <name>A0A6P8ILT0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetylcholinesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116302557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567747.1">
        <property type="nucleotide sequence ID" value="XM_031711887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302557"/>
    <dbReference type="KEGG" id="aten:116302557"/>
    <dbReference type="InParanoid" id="A0A6P8ILT0"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027725093" evidence="4">
        <location>
            <begin position="18"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="21"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031567747.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="67043" checksum="A135E78B3B6D9ADE" modified="2020-12-02" version="1">MFLSFTLLFIIISFSKQEKLSKVVETTSGPVRGHGVSIPKNKTVYQYLGIPYAKPRRFEYPTQENWTEILNANQYGKPCPQASSPYGIQRLEEASEDCLNLNIFVPDSKGKNLTVIVYIGGLLYSFGKANGTSFDPLAVASKGEVIVVSLNYRLGILGFFSAGVEVIKGNYGLADQIEALNWLQRNIQRFGGNPDDVTVVGHWSGAMSVGLLLVSPKAHGLFNHVILMSGSPLSLTATLDHVTAVERARKISEELKCTNRSNLKACLQSKSVADIILAQAKIQNVPILSPFAPVVDGXILTDSPDVLFKKSNQIKVKSVMVGIVEDDGAIFLSPSLPGLANNIGSVSQGINQSVLHYVIKSNILTNTPPPAERLISHKYXNWKNPEDQMANKQQLINVYTDASFSAPALRLAQLVSLQGISTYFYHIQKSALNTTLLPSIPMEKGVAYGNDVRLLFESEFTDESXRSGGAGGIVGQAFRMLMEFAKKGNPTPPSSHSPLKWPTYAPNDQYLSIGKSNISVQSKFLSDRIAFWNELLPSMMSQSLTNTPKPPLSTTTSRPDNGDXCVPKKEKTTKALTAVVAVMAIVIVVMLAIIVYQTRMLSKRPNAPPSQPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILT3</accession>
    <name>A0A6P8ILT3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BAI1-associated protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116302431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the unc-13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567580.1">
        <property type="nucleotide sequence ID" value="XM_031711720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILT3"/>
    <dbReference type="FunCoup" id="A0A6P8ILT3">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116302431"/>
    <dbReference type="InParanoid" id="A0A6P8ILT3"/>
    <dbReference type="OrthoDB" id="7976202at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08676">
        <property type="entry name" value="C2A_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04009">
        <property type="entry name" value="C2B_Munc13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="155"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="640"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="10">
        <location>
            <begin position="877"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="12">
        <location>
            <position position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567580.1"/>
        </source>
    </evidence>
    <sequence length="1174" mass="134308" checksum="95559E4E6EB8C93E" modified="2020-12-02" version="1">MNSKISEDENLERLRQSRKLGLCQKLSNQYKACYLEGLTPFDRSQKFDGGFFEKFISIDWKELGEGDGKNAVDSTQIEDLPEPGDLDKIEEGCGDVQEVLSDGKSSTLSQKQREALYCEALYTIIHQVGAKHSSLDPSNGELYVYLQEVLKISQEKHKELYAKTKDRETPRFYLKVGVIEARNLEAKDANGLSDPYCMIGLMSDSAEIEAKKGNAGKKLKKSRTLRELLKNEAIQMTTVRENTLNPEWNETFTMEVNNVSMDVLHIDIWDCDDKEMLSDQDNKVTKIKGFHGVGRYFKDVVQSARATENESTDDFLGYLEYRVKDIPSDGLDEWVKLKSKSSKCRVSGDCHVKVSLSSGNRPDLPQEVLSMYPTFSDVYGALLHEFAAYDLDQAKMMEEQKWEGQLSSHAHFILHQLAIQNDLTPLQEAAMRWRFLSQLHWENPIQYDTLCSLAQDVSKHWKPGKLSEREERSLLKSLRLFVNNCLQLLIKHRDLYPPIDNARFGRLVNLVECLQAVCEMDVYQEDNHEPLSQTLVSIIKESASIWYNKIHAWNEPQESSYDAKLSSMIRLAECVLTDFLRALKFYNKVFFIVGVNYFSLTYCQLELMLANDVRLLMESVKQSIRQSADDQQDVVGEKLFALYLAIRELMSYREHVKTSDNQVHGFDDFHLWFKSAVVRWLDIAQSKAKDRIAKAIAIDKFLRVDPSVMHSTSAVDTVGCFHQILEFWKNLDWPDVGCSYMFVTQLINIICVNALYYADLVFEKMIKEDFYDSDPTQFDVSEQLCVTLNDIEYIRLWLERLPTILGIDQVVSAMTRAHGENSGKHAKTSIDTVISSADEDMLNKIAKIIGHIGQKMAVDIKKFVIQLSWEQNPKPADEAIGPLLQYLDDDLMILNKSLMKSVFKEILEFMWEVVVENFSDMVKSSRGNPPEFFTRLQQSIEIIKAFFHADGVGLPNEQLTGGLYKSLQTTLTIRCMSTNELIQMYFVDLCERQDKSTETYGAVTIRALYDKENRKLLVEVLNARNLVALDTNGLSDPYVVLRLQPAHIFGREERKTKVVKNTLFPLFDETFSFSVTPEQCRMKGACLSLRALDYDMISNDDIEGQAFLPLNILAGLDSPMQGGFANEPQITLNLIHPTPDGVAFEILECRKDKEAETFVKNEKLTYEKIRSAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILY2</accession>
    <name>A0A6P8ILY2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 49 member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116302775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568006.1">
        <property type="nucleotide sequence ID" value="XM_031712146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILY2"/>
    <dbReference type="GeneID" id="116302775"/>
    <dbReference type="KEGG" id="aten:116302775"/>
    <dbReference type="InParanoid" id="A0A6P8ILY2"/>
    <dbReference type="OrthoDB" id="5983710at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031568006.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="37981" checksum="E15274921613CFE9" modified="2020-12-02" version="1">EIKERSPLLPAHSLQAEYSNNYKESLDTQGEETIPREAVFKVYKRRWYILTLYTAIALNCNMAWNAWGPISEPCKIIFGWGNWQVLFLASWAATSLILSAVPSTYLMDMKGLRKSVISCASLLTAGKVFQVIPSSDPLTRTILLNIGQCISMLSTPVGLGAPPSISATWFPPEERTTATAISTLVAYIGLPVAFIIGPYMVQILEITYSPQTNNTMNLNVSISNYTKVYDIDAMSSDLTKHMGVHLGISMFLLVCALLYFPDKPPLPPCETSGGPPHEYGESIQALLFDRSYLHLVVIFALSYGVYFGWISVLALAVKPFGVDESLAGWLGASATTAGIFSGLCLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN67</accession>
    <name>A0A6P8IN67_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis-expressed protein 49-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116302993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568294.1">
        <property type="nucleotide sequence ID" value="XM_031712434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IN67"/>
    <dbReference type="GeneID" id="116302993"/>
    <dbReference type="KEGG" id="aten:116302993"/>
    <dbReference type="InParanoid" id="A0A6P8IN67"/>
    <dbReference type="OrthoDB" id="7085216at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038775">
        <property type="entry name" value="SPMIP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35263">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35263:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22593">
        <property type="entry name" value="SPMIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031568294.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15448" checksum="3411859A478196A0" modified="2020-12-02" version="1">MAFFNLTQLGLQDTIKNGVKTPAAPIATGPVAGTQSENQLPVRTSLKEPVYPNSDANGSYVKYTERLHKHIRPQKGPNEIYDKKISNNYTYGWWMKDGVQREQWTKNSHHPMVRSEMTRFVDDMTLTNREFTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP48</accession>
    <name>A0A6P8IP48_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031568811.1">
        <property type="nucleotide sequence ID" value="XM_031712951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP48"/>
    <dbReference type="FunCoup" id="A0A6P8IP48">
        <property type="interactions" value="794"/>
    </dbReference>
    <dbReference type="GeneID" id="116303420"/>
    <dbReference type="KEGG" id="aten:116303420"/>
    <dbReference type="InParanoid" id="A0A6P8IP48"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031568811.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55037" checksum="57C5759FCD9291A5" modified="2020-12-02" version="1">MNLSHQILALDARYNAYRAPNNPQFRTLYLRRRNQLLRENAKKEKEDPTFRRQYLYIRKQLLSKRYGPSESSQLSRSRSASTYSRLSSFDTSFDSLPIDPGDLSHGYSPNRPTHRRYHSSGSFKFLPPPEKTESPPRGVVPTRKAEASRKMAGNTTLGENYAFGGMYHIFDQHAEAVTAIKFAHDDKYRLACSSADATLSVCLLMPSPPSVLCTLRGHLEVVTDFDWSVTNSFILSSSLDTTCRIWNPLSGRCLRVVTDSHACGITACRFQPCNNNMFITGNQKGIINVFNTSTGKSFKGGTGKVSSGICCMEFESSGMVLWIGDEKGSIYSFCFDISSGRIHKSKRIVVSEGNPVTSIGYRSWISREARDPMLLVNVCSDRLCLYSVTDEVGGLKPKAKFPISQKTKGIRSSFCPLMSFRQGACVVTGSEDMAVYFFDVERKDKPCVNKLMGHSSPVLDVCWNYDESLLASCDTEGTVIVWKREQQQHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQP3</accession>
    <name>A0A6P8IQP3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116303918</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116303918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569401.1">
        <property type="nucleotide sequence ID" value="XM_031713541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303918"/>
    <dbReference type="KEGG" id="aten:116303918"/>
    <dbReference type="InParanoid" id="A0A6P8IQP3"/>
    <dbReference type="OrthoDB" id="10390775at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569401.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="64815" checksum="D33A053E9C4D6CED" modified="2020-12-02" version="1">MSATSCGTLDGAKTINEEVESKCYRGFAPSIMAAMTGATTIDVVLPWENEIFXIKQKRGKYFSDTFFFYLATVSSYSKSNEIKLRAAEALKRNLTEIAETSKLLWMNIRKIYQLNQGIFEGLDVFFQDSLMQKSATIGDEAQKDKKADPKKIREVVNELSSEFENANALMKMFPREILDNPLRFQENIIYSQVHSALANTVHKDSLWQDATIAGRMKVFSDISIKENIKKATKNLFNTYIKGYHDAHRFSNITQDIAKRLDIVTERADEVKVVESCEEDKKTAQKLLDEAKELQNLVDHELYDIVIDFDRDLRAWFTDTINSFEFLDQLRQVLNLVSPIVPQNVHPELDELYSYVISRADKEEMPELAWTQKDGQSIYFLKEGSLKPYEQLSNMIFKVNKVSECYRKVFQFVGQTVQGCSDGVGSLREIYDEISSRISIDESKCWSVSLFSQPSFQEIKQTVEKAAKKFGFNKDCEQNTPQQDEAGNVRSIIIDDYSDESENEKFSPTQRFMVCNLRVKHSMSDEKINERMDIRDLPKVKAVRCKNNKRADSMYARESQIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR10</accession>
    <name>A0A6P8IR10_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="25">LOW QUALITY PROTEIN: dynein heavy chain 5, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116304022</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569531.1">
        <property type="nucleotide sequence ID" value="XM_031713671.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116304022"/>
    <dbReference type="InParanoid" id="A0A6P8IR10"/>
    <dbReference type="OrthoDB" id="5975644at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF18">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="16">
        <location>
            <begin position="114"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="17">
        <location>
            <begin position="275"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="17">
        <location>
            <begin position="358"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="21">
        <location>
            <begin position="624"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="19">
        <location>
            <begin position="756"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="18">
        <location>
            <begin position="1032"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="20">
        <location>
            <begin position="1405"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="15">
        <location>
            <begin position="1871"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="22">
        <location>
            <begin position="2011"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="23">
        <location>
            <begin position="2158"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1040"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1260"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1566"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="25">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031569531.1"/>
        </source>
    </evidence>
    <sequence length="2455" mass="280404" checksum="BA4C601B255B2594" modified="2020-12-02" version="1">FVTTEKLKSSLCAETKAWCVAFGRNCNIKYRTEMEEIFAFLEDMTKRLSRPIKDLDDIRLAMNALKEIRDKEIKVDMCLGPIEESYQMLSRYELPIAREESERVDTMRYSWQKLQALADVCIAAVKEKDIEAKLKMVIADWNTKDFTFANFKNRGELLLRGDNTSESVSLLEDSLMVLGSXXXXXXXXXXKKTIQTWVQKLSNTTDIIENWMTVQNLWIYLEAVFVGGDIAKQLPKCRMHIRTPADFEWLKQIRFYFNEDTDKCNVNITDVSFEYQNEFLGCTERLVITPLTDRCYITLAQALFMSMGGAPAGPAGTGKTGLKIYGCPFLKFFPSFLSFLPLSLVXXXXXXXXXXXXFDEFNRIDLPVLSVAAQQIYIILTCKKERKKQFIFSDGDVVDMNPEFGIFLTMNPGYTLQCXMQLVSQRRSEXSCKENCSVHYDFGLRNILSVLRTLGAAKRSNPGDSENTIVMRVLRDMNLSKLIDEDEPLFLSLINDLFPGIVLDKAGYPELEQAIANQVEEAGLINHPPWRLKLIQAALLIGEQGTAKTVMIKGHMNKYDPEKHLSKSFNFSSASTPLLFQRTIESYVDKRMGSTYGPPAGKKMTVFIDDVNMPIINEWGDQVKMLPTPAKFHYVFNLRDLSRIWQGMLNTISEVIESERAVLNLWKHECIRVISDRFTNQQDKEWFEKTMKRVVEDELGEEYQPLIEATSYFVDFLRXGRSQEIVEKPXESFDSLKDRLKMYLEQYNESIRGAGMDLVFFRDAMIHLMRVSRIVRTPRGNALLVGVGGSGKQSLTRLASFIAGYKIFQITLTRSYNASNLMEDLKYLYKVAGQQGQGITFIFTDQEIKDEGFLEYLNNVLSSGEVSNLFARDEIDEICGELIPVMKKEFPRRPPTGENLYDYFLTRAKHNLHVVLCFSPVGEKFRNRSLKFPGLISGCTMDWFSRWPKDALIAVSNHFISNFDVVCTPEVKNEVVHSMGVIHDGVANCCSDYFQRFRRATHVTPKSYLSFINGYKSIYAEKRKEIGDLAQRMNTGLDKLMEASESVAQLSRELAVKEKELAVASEKADRVLKEVSVKAQAAEKVKAQVQKVKDKAQAIVDDIAADKIIAETKLEAAKPALEEAEAALQTIKPLHISAVRKLPKPPHLIMRIMDGVIILLKKKLDPVKFDAERVSVVPSWAEALKMMSKSDFLQSLMNFPKDSITDETVELLAPYLEAEDFNIETAKRVCGDVAGLCSWVRAMSVFFGINKEVLPLKANLAIQEVRLRIAEGDLNKAQAQLDEKQAELDEAQAMYDKAVQEKQDLLDSAEACRRKMLAASALISGLGGEKERWTEQSKEFQEQIGRLVGDVLLCTGFLSYSGPFNQEFREMLMSNWQKEMKSRKIPYTANLNVTGMMVDSTTVGEWNLQGLPNDELSIQNGIIVTKAPRYPLLIDPQGQGKAWIKKREKDNELQITSLNHKYFRTHLEDSMSLGRPLLIEDVGEELDPALDNVLEKNFIKSGSTFKVKVGDKEVDVMKGFMMYITTKLSNPAYTPEISARTSIIDFTVTIKGLEDQLLGLVILTEKAELESERTKLLEDVSSNKRKMKELEDNLLYRLTSTQGSLVEDESLIEVLSVTKQTAEEVSQKLIVAADTEIKINTAREEFRPVATRGSILYFLIVEMSYVNCMYQTSLKQFLGLFDQSMARSQPSPITSKRIRNIIDYLTLEVWKFSCRGLYEIHKFLFTLLLTLKIDLQNKKIKHKEFMTLIKGGASLDLKGCPPKACRWITDITWLNLVELNKLPQFSDILNQISRNEKQWKHWFDKEAPEEAEIPDGYANSLDTFRKLLLIRSWCPDRTISQARKYISESMGKDYAENVILDLEKTWEESDSRTPLINLLSMGADPTGMIEMIAKKHKFDCRAISMGQGQEIHARKLVNTFMQTGGWALLQNCHLGLEFMMEVMDLVTETEQVHEDFRLWMTTEEHPQFPIGLLQMSIKFSNEPPQGLRAGLKRTYNGISQDQLDICSLSQWKPMLYAVAFLHSTVQERRKYGPLGWNIPYEFNQADFTASVQFVQNHLDDMDIKKGVSWNTVRYMLGEVQYGGRVTDDFDKRLLNTFAKVWFSESMFSQNFNFYKGYTIPKCNSLQQFMDHIENLKLVDSPEVFGLHPNADITYQSNLAKACLDTILSIQPKDSASGAGETRESIVQRMADDMLEKLPEDYIKHEVKAKLQKMGALSPMNIFLRQEIDRMQRVISAVRQTLTDLKLAIDGSIIMSETLRDSLDCMYDARIPEHWKKISWESSTLGFWFTELIERNAQFRSWCFDGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDCVVLHNDVTRFFKDDXTSPPTEGVYVHGLYLDGAGWDRRGCKLIEPAPKVLFTSIPVVHIYAINSTGGRDNRLYQCPIYKKPRRTDLTYIACVDLKTNQNPDHWILRGVALLCDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRU7</accession>
    <name>A0A6P8IRU7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303555</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568973.1">
        <property type="nucleotide sequence ID" value="XM_031713113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRU7"/>
    <dbReference type="GeneID" id="116303555"/>
    <dbReference type="KEGG" id="aten:116303555"/>
    <dbReference type="InParanoid" id="A0A6P8IRU7"/>
    <dbReference type="OrthoDB" id="5976713at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028206902" evidence="1">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568973.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12519" checksum="9E2657F26A8AB091" modified="2020-12-02" version="1">MTMTPNMILFVAVFGIFVVLVKSQSYDVLCSDIRGDKCVKDENCKCSEATFICNRFSRCDRPTLEDIRYRQPCRGIFKSSCVDDSDCNCKGDRLVCEDNECVRSKTITAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISK8</accession>
    <name>A0A6P8ISK8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031570176.1">
        <property type="nucleotide sequence ID" value="XM_031714316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISK8"/>
    <dbReference type="GeneID" id="116304559"/>
    <dbReference type="KEGG" id="aten:116304559"/>
    <dbReference type="InParanoid" id="A0A6P8ISK8"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031570176.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25793" checksum="1B259DBC56C6073F" modified="2020-12-02" version="1">MEYLTLPSKPTYSSSSSSEKQGIIYNAKRMRRGSNQNSKSLNVAVLGKDGVGKSAFIVRALTRRFIGEYDSKFECTYKHNIDVDGHSMSIEVLDTVGNNTLARLDNTTSHIELFFVLYSATDRSSFTEASRLIKYLSETRNIDPACVTIVATKKDLKHMKEIEEYEGRFLAQDIGCSFYQISISEGYSETLKTVQEAIRKCMSYQNMKKKGGFFDTMLRRRSWSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISN2</accession>
    <name>A0A6P8ISN2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Radial spoke head protein 3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagellar radial spoke RSP3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569994.1">
        <property type="nucleotide sequence ID" value="XM_031714134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISN2"/>
    <dbReference type="FunCoup" id="A0A6P8ISN2">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="GeneID" id="116304404"/>
    <dbReference type="KEGG" id="aten:116304404"/>
    <dbReference type="InParanoid" id="A0A6P8ISN2"/>
    <dbReference type="OrthoDB" id="313308at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009290">
        <property type="entry name" value="Radial_spoke_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648">
        <property type="entry name" value="FLAGELLAR RADIAL SPOKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06098">
        <property type="entry name" value="Radial_spoke_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="191"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569994.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45480" checksum="A2106F2EF0DFB1C2" modified="2020-12-02" version="1">MAAVLAQKGDPSRTYTFASQPRPVQQRKKFRDPLTQQNESPMPYGNIMYDKRIVRGNTYAQRTLPASAQPDPIEVQRQQEMRRRAIARKRAKDQLQPRSPEPVTGRKHIDVQTELYLEELSDRVEEAEVETQTDAFLDRPPSPLFIPAKTGVDVATQILDGELFDFDIEVKPILEVLVGKTVEQALLEVMEEEELANLRAQQRQFEELRNAELVETQRLEEQERRHREEKERRMRQQAEVLRKEKETGDKIAARAFAQSYLADLVPSVFGSLNENGYFYDPVERDVETYFMPWLMERVDENLDQSMLARTLLDVIIREVVSKRQSVYGKLDEEIRQAQEKEAMAKAAAQRKIIKETTSPEPTTDIPSEETAAPEEPSEELGAEPLADENPEPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT23</accession>
    <name>A0A6P8IT23_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304713</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570346.1">
        <property type="nucleotide sequence ID" value="XM_031714486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304713"/>
    <dbReference type="KEGG" id="aten:116304713"/>
    <dbReference type="InParanoid" id="A0A6P8IT23"/>
    <dbReference type="OrthoDB" id="5972189at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031570346.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24706" checksum="453A0B32C1BF8F71" modified="2020-12-02" version="1">MEICCSFKTIVGGTCGFDRKDRKQDTTVXPLQACKKEINAHRSAFQFTGIENEIDLILSRAAIFTSPEDIHSWTVCPLHRSKLGLGWARGNNARCRVPNTLSNHSEIKGKWPKCDRGISKDDSQLILKKTGISLQVGSGICSYCRKTLKTLGPISPNKAESLLDQMSALPLNSDNEDEKVKFGPQFTTPTFQASAGVVTETPMSLYQPGKTSFASTISEDEYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWC3</accession>
    <name>A0A6P8IWC3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein LOC116305596 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116305596</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571394.1">
        <property type="nucleotide sequence ID" value="XM_031715534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305596"/>
    <dbReference type="KEGG" id="aten:116305596"/>
    <dbReference type="InParanoid" id="A0A6P8IWC3"/>
    <dbReference type="OrthoDB" id="2121937at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000044">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1354"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1565"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1605"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1659"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1702"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1772"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2043"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2077"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2131"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2170"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2228"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="15">
        <location>
            <begin position="1187"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="14">
        <location>
            <begin position="1400"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="935"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2481"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="937"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2496"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1878"/>
            <end position="1894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031571394.1"/>
        </source>
    </evidence>
    <sequence length="2516" mass="284207" checksum="025273754B4B2837" modified="2020-12-02" version="1">MAAIIFSCEMAIADKLRYGSPNFIFVKYTFLITILVHSACLFSTSPKASCRDPLGMENGIIKDNQITVFSAYNDDFNTYGAQRARLNLKTWPQGHRAKPDKASSTWLKIELKENMIITGIATQGYGDPSVGEWVKQYMLLYSTGKDYLYFKDQSGGLKMFAGNTDWHSIKRNEVPIPTVVKSIMLMPTDYHTNFALRMELYGCKPGYYFIVSLMILDTYFTTIFLNSNETMYKTMKEDTEMEVGYALEGVAGYLGAKLERFSPEKSQYSELNLMAEVRINCIEASVHFLTTKLQSSIQQTEGLFQSSSMKVKYPLDFSCRPPSVKVNLSKTEAEASIVHLTDPITLKGEVELRCNATSETLYAWELAHVRMENKQLISPVTFGMGLIQVTEKARKWGVGLKYVRFSASMIGQEGTTSYDYGFINVTLPPLVANIKGPKEVVKGTGPFVLDARDSLDPSDPFTKYKGITFIWLCRRSGESFTGVNMSHPFDVISVTRKRNKGGCFGYGPGKMNETGPLLHVEPAFMASKNVYVFQVIITKDNRQTKLEHQMRVNSSLSLSLRCLINCGHKVSTNLRMTVEAVCKGLTCKAIQSHNWVLYTNIASHNVTVPKWQKVDDLEEKSLTDLDSHSIVIKGRLNENFNALENDAEYKLVGEVLLKDGSVERDQMTFITNSPPQGGYCMADPEIGTAVTTEFYVQCDEFKDDDLPLQFEFRYHTNTGMIVIEKTFSNHIITRLPLGDPVADYIVPIEVLVSDSFGGSSMDFTFVFVKPMITKDVSGTLKSMTSGKNSAMGNLLKSGDVSKATQMAYAVLSLVDKSEGNIEATDRKSVDIVRTQLRSKLKVTKSSVKNLKDGIIDQISKVKVKNLEQVTQVAAVVALATGQKDEISQKSQENAVGLLEDTALFMANQKNDNPELLQKVGASLLHGIGNILSAASNEAKETANEKEKRGNRHKPDKESEETKKKGKEMSEKTLQLMEVVGGSLLSTKTVGEKPSVFKTKNMALLLDRQMASKMGNKKLGEGDSEVALPSADTLFGNNSDNMAAIDSQMMAFDENPFTWDSSSKNVRSSVVEFKFKTSHGKVLDITGLSKPIELYIPQKLQEEPQNVNNSSNEYFVKPSKNKKNIRSHQITIPSHDAAVSVTIKPQDGINLVVYVRHLLKPTPDSYDLKKIMPDYTSCLNYDVEMGYQNCTDDPYTLTISSASTGEIGIHYIGVQYTPVQSMDPVNPSDGEVISARLRRDCYSHSGRVKRGCIGVKDPPTTPAPTPLIIVPLYNGSTDVNYTMSVSVTSCLYWSEKQSKWTSEGCKVGPKSNARKLHCLCTHLSAFGGDFFVAPNPIDFDKVFAEFGRLGETGNFVVLATVCGLFGLYFIGLVFARKADKRDDTKVIANVYLREKDMQEGYIYQISVQTGMWRGYGTTANVGIRIYGEEGKSDDILLTDKSLNKTFFSRGSVNNFTIALPVSVGELLKIKLWHDNSGPSPAWFFQQVLITDAQTGEQWHFLGNRWLAVEKGDGQIEVEILKADKKQLSGFKNLFHSRTARSLGEGHLWLSIFTRPPHNTFTRCQRLSCCLSILFAAMVTNAMFYQFGTEPKDTFNIGPLKMSWTQIKIGIQSSIVAIPVNILIVTIFRNIKQNVPDNDNHREDGNSNSKKKKTPGCLPHFFIYIGWTLCILTSLAAATFTVFYSLMWGANTSNQWLTSIMVSFFQDVIITQPIKVIAIASLLSLVLKKPPENDVVLGESLKNEKENGNRKGCVAPRGEELEKQREYQKKVIEMFRTLVEIIFFMIFLLLVTVVCYGNRSVSRYHMTEGMEKLCSGFEKALTTDKFWNWTKNKLLPALYDTDWYNGEPFTSEEGFVSNREMFIVGMPRLRQLRMRPERHCSIEKKEPRISHQFKRCIPKYSHEHEDKTEFNMPGWNPVYNVNATMSLFELWDLCPKPWRYRTARSLNSLPFQGAEVSYDGGGFVADLGYDVGQAMDVINNLEYHKWIDDKTAAVIVEITVFDPATLLFSHVKYLYERFTTGGTNVRTTIKTLVLYSSSDQTFQSFYQVCQLMLMLMILFFFFVEIGKVYRQGRAYVRQFWNWMELVQIISAVSAIVMFFFKEKYTSDFVRKVQNNPYETSSIDYIILWSDLEIYLLSLVIFIVTIKFLRLIRFNRSICQMTGTLVRSAKNIWSFFIIFVAILLGFTQLGFLAFGATVTAYSSFFQSLRSVMQMLLGGEMHFYELQSTNGIIGPIFTFVFMFSMTMILLNMFLAILNESYEETREDENSDDFADADLCDFMFSYFGSKYKLFLEEYKNVQTKILSIAERFIRQRRKRKEEEYHRLHAEEVKETDVCEDESNRKKSGLVFLASIESFHDLLSDENLDDIKSNITDLKQSLTSLHSLEGNKLLPLPKEYESQAYASPKWDSPEVEISPVTSSQQTSIFDRPPPYERSIFDRPLEPVTSIFDRPNHSYFSGRYSPFSSSRALNYQGVRQSKYLLMDEDEDGSTANENSRLLTPKYPTVDTTTTSIAGSDGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWN1</accession>
    <name>A0A6P8IWN1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sacsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571477.1">
        <property type="nucleotide sequence ID" value="XM_031715617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWN1"/>
    <dbReference type="GeneID" id="116305660"/>
    <dbReference type="KEGG" id="aten:116305660"/>
    <dbReference type="InParanoid" id="A0A6P8IWN1"/>
    <dbReference type="OrthoDB" id="5979513at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052972">
        <property type="entry name" value="Sacsin_chaperone_reg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600:SF42">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="1">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571477.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14209" checksum="FAA5BF6DB72B87F3" modified="2020-12-02" version="1">MSKRVEGRSYGQRVPPLTSVIKSILERYPDGGQILKEIIQNADDASATSISFLLDSRANPYRRSSLYNEELAKFQGPALYSFNNALFKEEDWDGLQSLMDSNKKEEPLKVGRFGIGFNSIYHVTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX46</accession>
    <name>A0A6P8IX46_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116304953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570618.1">
        <property type="nucleotide sequence ID" value="XM_031714758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IX46"/>
    <dbReference type="FunCoup" id="A0A6P8IX46">
        <property type="interactions" value="1409"/>
    </dbReference>
    <dbReference type="GeneID" id="116304953"/>
    <dbReference type="KEGG" id="aten:116304953"/>
    <dbReference type="InParanoid" id="A0A6P8IX46"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570618.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15839" checksum="EF966D8E15F88665" modified="2020-12-02" version="1">MAEKAEDLNLPNAVIARLVKDVLPDGVNIAKEARSAIGKAASVFVLYATSCANNIAISGKRKTLTAADVLQALEEMEFEEFLPKLQENLAAFKKEQKGKKEAAAETKRRKSEISSEDSAPEAKKQKTDDDNVPSDSKEKSENGTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZZ5</accession>
    <name>A0A6P8IZZ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prosaposin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116306814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572779.1">
        <property type="nucleotide sequence ID" value="XM_031716919.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116306814"/>
    <dbReference type="InParanoid" id="A0A6P8IZZ5"/>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000002">
        <property type="entry name" value="prosaposin isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028079962" evidence="7">
        <location>
            <begin position="16"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="254"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="10">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="10">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031572779.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39370" checksum="89E5E3ACAD16E597" modified="2020-12-02" version="1">MKFFVILLLAVAANAFPKLTPRLKQEIEAEKLSSLLMPGPVLTPNKISVEVEPVNASPECILCEYIMDKLDQMLTQNSTEEEIKEALKKVCSLLPSTISAECTEFIDQYADLVLKYLSQGLNPQMVCTELGLCKGLNLIQDVLPNTNDVVVINEVGSTTSCELCKTVAQELESLITQNSTQQEIEQALEQVCSLLPAELKKECNQFVEQYLPEILNLLXLEITPDMLCKELGLCPSLLKATAVEVMEVTAPKDANLTCDFCRKIIGLAKELASKNDTEQDVEKLLDLVCYYMLPIIKECKDFIHNTIPEIFDELKKMDPDAICKQLKLCPELSGMNXEVRGFMTDFNRDVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1P0</accession>
    <name>A0A6P8J1P0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Adenosine receptor A2a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116306134</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572038.1">
        <property type="nucleotide sequence ID" value="XM_031716178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306134"/>
    <dbReference type="KEGG" id="aten:116306134"/>
    <dbReference type="InParanoid" id="A0A6P8J1P0"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031572038.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27299" checksum="45DA831E3A2B6AAE" modified="2020-12-02" version="1">MXEALGFTVIKWYALPHMSFFIGCTASLLIIALLAVERSIAVHANYHRKLPKKRAVNMSIAIWIFXFTFPCIYFQIGYFKFAFIFAILMIIVTFVIMVIAFIRIHXNMRSTTVRALTVQPMGSAQEKTSQKQLKRAERERRVTRIFTAILIFYTTCNLPAFVFIFVVNFCSTCSCVFIHWSRDLLLVCVLVNCSGNQFLYAWRMKSFRRAFRSLVHLPLTDEASVIQTRDTRDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2C9</accession>
    <name>A0A6P8J2C9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immediate early response 3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116307934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574126.1">
        <property type="nucleotide sequence ID" value="XM_031718266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2C9"/>
    <dbReference type="FunCoup" id="A0A6P8J2C9">
        <property type="interactions" value="1301"/>
    </dbReference>
    <dbReference type="GeneID" id="116307934"/>
    <dbReference type="KEGG" id="aten:116307934"/>
    <dbReference type="InParanoid" id="A0A6P8J2C9"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574126.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="8936" checksum="E25574B75A887BE6" modified="2020-12-02" version="1">MAFTFYGLLEACLLVVNAIAILHEERFLAKIGWGTDQLAGFGEEKGTKHQVINLIHSVRTVTRIPLIFLNSVAIVVLILMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2K0</accession>
    <name>A0A6P8J2K0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein 816-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574211.1">
        <property type="nucleotide sequence ID" value="XM_031718351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2K0"/>
    <dbReference type="GeneID" id="116308002"/>
    <dbReference type="KEGG" id="aten:116308002"/>
    <dbReference type="InParanoid" id="A0A6P8J2K0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574211.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="20772" checksum="ADC818A640098A55" modified="2020-12-02" version="1">MDCLKCKKVFSTKQRLQYHVWHGVCTKEPISKVCSNCNREFSTLQKLQYHVKKGVCGRTTQCSYCDKVLSSRQRLRTHKKKHEKRYRYFFTKYDLEGVDCYQCGDIMSRCEHRDDYLRNRIDYFRKISRTLPCFDALEGVPWTNREYWRQQCERCGCVREEEHIFNCLFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J371</accession>
    <name>A0A6P8J371_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LOW QUALITY PROTEIN: transformation/transcription domain-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116307870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574049.1">
        <property type="nucleotide sequence ID" value="XM_031718189.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J371">
        <property type="interactions" value="1355"/>
    </dbReference>
    <dbReference type="GeneID" id="116307870"/>
    <dbReference type="KEGG" id="aten:116307870"/>
    <dbReference type="InParanoid" id="A0A6P8J371"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="1834"/>
            <end position="2413"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="2743"/>
            <end position="3065"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3069"/>
            <end position="3101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1666"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2431"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1676"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2434"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2476"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2513"/>
            <end position="2526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031574049.1"/>
        </source>
    </evidence>
    <sequence length="3101" mass="351826" checksum="527F82B53A57155C" modified="2020-12-02" version="1">MDRSNLYLKLFKLVFGSVSLFASENEQMLKPHLHEIVNRSMDLACTSKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLNNLQSGVHRQYMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELFQALWKTLRNPNDNIAHVAFRVLGKFGGGNRRMLKEPQKLTFNEADTLGPCLAIYYPESVNPVTVSVGPVIERALAFLKTLPPNVSVLPQQSSINLDHTIFYRKQAWIVIKSYLVAVLSLEDTNTMLLQVLSHKSFREGQPPVVGKTAVLPCTDLPSKKIMEQALTGALLSASIKELRSEAVPFMCNLVRHFTLIGMVQQAGPCPTKLQNRTPKGVDVHIIAEAIATVMGMEDKEFCKVGELAVAVMIETATAVTGNPYKAAQLPLFEYLSEKLIGCCYERAWFTKSGGCTAIRFLMKRMPLRWLIEHQLSFINALFFVMMDLTNEVSAGTLDSAKEILTELIEKCNTPVTETNDPTIKLVQQKIFPNLCQHLIREIVSPNETVRKQAQTSINLLARICNKTVYDIMAPHKGILEDMIPPKKHLLRHQPVNTQIALMDGNTFCTTLSPRLFTMDLTIVEHKVFFTELLSLCEADDAHLLKLPCYKSVQSLTPLRKSAHLKKWAEVIITVTTQAQQNTAGKIPRKAEDVGSPLRGPLLKFLVRYPTQTCDYFLLHIAEPQMNRLLMHYLKMKEDAKILRATLESYSLKLVNSLFNVQQPPEDQVAAIQKKMELQYQGILIIRLLVKFNDNWLPDHPVIIGHLRRVWISKSFQDRLNKDGTPVHRWREPKLLVKCLLNYIKHRSGEVELLFQLLRVFTLRHVPDFHFLRKFLDENVAKQYNIQQKRHVFFQFVKLFEDQYFPQELKAKALQYVLIPMFQVSFERGEGDSLIGGPPNPEHDSADNVISVFVSKVINPDNPFGTSDAVRILLLQFSALLVEHASQHIHDAANKKQGTKLRRLMTFAWPCLLPKQCVDPSTKYHGHLLLAHIIAKFAIHKRIVLQVFHSLLKAHAVEARGVVRHALDILTPAMPARMEDGNAMLTHWTKKIIVEEGHTVAQLVHMLQLLVRHYRVYYPVRVHLTQHMVSAMQRLGFTANAVIEHRKLAVDLAEVIIKWEMQRIKDEQDQTFTPEIEPPTTPSLKRPAEDASTPQDTKRTRSLSQTSAAARAAAAINESKLKSPLEKHHSDALVXXXXVNEPSTTVGSQGESLSRRCVLLLKTTLKPDLWPGADLRVAWLDKLLVTVEQTPAANYANVCTAIEILTYLLSVLPQQTILMLFKPLQRGIATCMTCQNTKVIRAIHTLLGRLMTLFPLDPGATKYEELEGLYSSIGKVICDGLTNFERAANAATSILYGPLMMLKAACMHNPSYIDSLMNPFMRALQRMHKDHINAVLGESTGASEMLILCLELIKNRLGIMTPEIRKHFFTIIITLIEKSPDSKLLRAITKIVEDWIKTKVTQLTIQHLPTLREKTVLLYRMMINYEKRFPDDFELQAQFLELVNFVYRDETLLITELASKLEPAFLSGLRCVQPQIRSRFMEVFDKTMKKKLYDRLVYIFCSQNWESMGAHFWIKQCIELLLAVSDCERPITPSSTYSMLPSLTSLVRATDSPVTKEIMKEVRKASIGQDSKTNTDTKPMETDQEKENIEKENVFLFAEKDADKLFELMENQKSTDLTSRTQAGQMVKDMVTHHTTFLDDIREVKSAAFLGATAQLCHSNSKLAHKIWVDLFPQLWNMLSDRQQQILAGELSPFMCSGSHLVQVDVHPSAVHSILEGVSKCDPAVPIRPCILKYLGKTHNSWHRSALTLEEYASLCEEYTNPHIAQQQQQVVDYTLYDEDATEINPNETLDSLAEMYSHLNEEDMWASLWQQRCRYPETSTAIAYEIQGFFEQAQNSYELSMNKAREEHNRGPASPAVLSEYKLWEEHWLRCAKELGQWDLLMEFGKSKSHPNPVLVLESSWRVPDWQAMKDALAQVELNFPENIAYKLNLYRGFIAICHPEEPHPNMVDKLVEHSTSQAIRQWRRLPAIISHQHLPLLQGAQQIIELQEAAQIHIGLQPQSVGRSASLHDMKAIVKTWRNRLPMPSDNLSHWSDIFMWRHHHYQAIVAAYEGQSSHEAQQSNHAMLGVHASAWAIIHYGYIARKQNLTGVCLDSLSRIHTIPSVPIVDCFQKIRQQVKCYLQMAGSMGKTELQEGLEVIESTNLKYFTKEMTAEFYALKGMFLAHIGRSEDANKAFSQAVQMHDSLVKAWALWGDYLDNLFTRERNMQLGVSAIVCYLHACRHQNETKCRKYLARTIWLMTYDDDKGSIADAVDKYCVGVPPVHWLPWIPQLLTCLVRKEGQKILNLLGNIGRVYPQAMYFPIRTLYLTWKIEQRERHKVEAAAAAIANHRSQPTPTNGATGDSSGDNKNITSVPPSTDPATTILTTPQVKTADPTSGATPSSATKAASTTSSAPVSSSASADQTNGTNPSASINSNSSSQSDPGAIRATAQMWRCSKIMHMLRDLHPTLLSALEGIVDQMVWFRECWHEEVLRQLRQGLTKCYQVAFETRGDVSSARITPHTLSFVKKLVSTFGIGFEPASSVSTTLSTAASESLARRAQATAQDPVFQRLKEQFASDFDFSVPGAMGLHNLIGKLKKWIKILEEKAKLLPSSFLLEDRCRFLSNFTTSTAEVELPGEFLMPKANTHSPYYIRIARFMPRVELVQKHNFSARRLFIRGNNGKIYPYLVVNDACMTESRREERILQLLRLLNLYFEKRKESCKRNLLFTVPRVVAVSPQMRLIEDSPSFISLREILGKRCDRKHLESDSSIALYYDRLAAVQSRGLQVTHQVLRDILREIQGTMVPEVMLKEWAQYTYTDPTDYWTFRKQFCVQLTLLGFAEFTLHLTRLGPEMLQVAQDSGRLTVTYYRFEVDDSKGELDANRPVPFRLTPNIAEFVTPVGVNGVMTASMVAAARCLVEPQFSIQSILRAVLRDEMITWHKKKHDESHPHPITVSPTDMDSELLITLVNGAVNAIMTRLQNLAQYEGGETKVSTLVQAATSPDNLCRMDPAWHPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4P6</accession>
    <name>A0A6P8J4P6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoredoxin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574652.1">
        <property type="nucleotide sequence ID" value="XM_031718792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4P6"/>
    <dbReference type="FunCoup" id="A0A6P8J4P6">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="116308385"/>
    <dbReference type="KEGG" id="aten:116308385"/>
    <dbReference type="InParanoid" id="A0A6P8J4P6"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007600">
        <property type="term" value="P:sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02964">
        <property type="entry name" value="TryX_like_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029519">
        <property type="entry name" value="RdCVF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46762:SF1">
        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574652.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18547" checksum="A9D702827AFB8FD4" modified="2020-12-02" version="1">MNVFSGRQLCKRSGVIVYPEEVVQSKVVALYFSASWCPPCQEFTPILKDFYEELQANDMPFEVIFISSDKSAEDMDRYMKESHGDWLALSFGNEMIKELKTRYHITLIPKLVVIDDDGEVVTLMGRREVTENGPKCFKQWAHAVGVARGEIATTVTRGTVSEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5F8</accession>
    <name>A0A6P8J5F8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bone morphogenetic protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116307151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573163.1">
        <property type="nucleotide sequence ID" value="XM_031717303.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J5F8">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="GeneID" id="116307151"/>
    <dbReference type="KEGG" id="aten:116307151"/>
    <dbReference type="InParanoid" id="A0A6P8J5F8"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13761">
        <property type="entry name" value="TGF_beta_BMP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000003">
        <property type="entry name" value="Bone morphogenetic protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF310">
        <property type="entry name" value="PROTEIN 60A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028087790" evidence="10">
        <location>
            <begin position="25"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="11">
        <location>
            <begin position="277"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031573163.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46131" checksum="893A0A59482B8013" modified="2020-12-02" version="1">MLLRKMRLTIFFLLCLLIAVLCQGTQPKKNVASQDVGMSSTFKQEILNLMGLPRRPRPNMVTRLYGRRFSAPLYMMKLYNSLSQNQTYHDGFCCNGTIADWRALGADTIMSYLNQVKGKRPKISHHHAIFKFKVESPQXEKVTATEFRLYKEIMPADKQSWRNSTYVVRLYQIIYPAQVLDLLQTRVLRNWESGWQAFDITKAGKVWSENPSKNYGLELSIVNLYDEEVSPYRAGFVGFHGPQEKRPFLVSFFRQDGNGEYFKRFYPEEVRQHRAARVPRSLDSQLGGGGGNYQQGGSKLCQLRLLHVSFRKLRWQDWVIAPEGYSAFYCHGECSFPLNSNMNATNHAIVQTLVHLMNPKTVPKPCCAPTKLSPISVLFFDDSNNVVLKKYNSMVVKACGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5N1</accession>
    <name>A0A6P8J5N1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="4">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031575009.1">
        <property type="nucleotide sequence ID" value="XM_031719149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5N1"/>
    <dbReference type="FunCoup" id="A0A6P8J5N1">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="GeneID" id="116308675"/>
    <dbReference type="KEGG" id="aten:116308675"/>
    <dbReference type="InParanoid" id="A0A6P8J5N1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032228">
        <property type="term" value="P:regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13364">
        <property type="entry name" value="PH_PLC_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08597">
        <property type="entry name" value="PI-PLCc_PRIP_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000025">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000001">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF196">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="77"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="572"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="691"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031575009.1"/>
        </source>
    </evidence>
    <sequence length="1059" mass="120575" checksum="9E3963FA28D0D405" modified="2020-12-02" version="1">MADNSSEISTGFDSQTSNGDNEELEDRDEVFDHIPMPRKASVLKKEGRGPKRSLSKSVSFSSRPEDKKIINAADCLTFIQNGCELMKIRSNSRQYQRFFSLDEDFTTLRWKPSSKKPEKAKINIHSIREIRTGKNTEVFREVDRDDIQEDCAFSVIYGDTFETLNLVAYSPDEANIWVTGLRCLIDSDKAQSPVEHRQQMRDRWLKEQFILADTGAKGRLNEKEVLNVLQQLKVRIPETIVKQKFKEATTISSAPHKNSLSLDEFLSFYKELTTRPEVYFLLARYASNNDSLTTDDLLLFLEAEQGLTRVGKDDCLEIISRCEPTEEGRKKKCLGIDGFTQYLMEPDCDIFDPEHSKIWQDMDQPLSHYFIASSHNTYLLDNQLSGRSKVEGYIIALQQGCRCVELDCWDGANDEPVIYHGHTLTSKILFKDVIEAIEEHAFEVSLYPVILSIENHCSVKQQQVMAKYLKEILQDKLYTSSPGENESCLPAPEALKEKILIKNKKLPCFTDDTSEAGEVSEDEEDQEDNGVINGDYTKLDRQSTRQGSFKRQTLKHDVNKNPKKTIKLARELSNLVTYCKSVAFKDFQYTSENQQFWEMCSFSETVARRLLTTSSEEFVNYNKTWLSRVYPGGKRVGSSNFNPQEIWNCGCQMVALNYQTPGVMMDLNNGKFLENGECGYVLKPSVMRDEISYFNPFTKDTIPGISPQILQIKIISGQQFPKPKGSTAKGDVIDPYVTIEVHGIPSDVAQERTRTVPHNGFNPLFDETFEFHINLPELALVRFIVQDDDFIGDAFIGQYTLPMECLLPGYRHIRLLSFTGEPLDSATLFVHVTITSFNEAGQKQRKLSLRKSKKGREYTSMKTVGVKSVDETFKSAIQPLRDGADLRDNLLTALSNFKEICGVAPRANLKQCIRLLASRLETVTETVHLELLMKDEQYPFFEASGNIPDMLRRALSAIDQIVQESKNLIENGDTIYERIMHCQRSGLEWHEDLYDTCTKEGLKGKRLSKALESFAWNIRVLKGQAELLIAAKQECQEYLRQIQEASIASGLVRSVGSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JFV0</accession>
    <name>A0A6P8JFV0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575185.1">
        <property type="nucleotide sequence ID" value="XM_031719325.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116308822"/>
    <dbReference type="InParanoid" id="A0A6P8JFV0"/>
    <dbReference type="OrthoDB" id="7772680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="550"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="715"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="5">
        <location>
            <position position="988"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="5">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="5">
        <location>
            <position position="1108"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="5">
        <location>
            <position position="1164"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575185.1"/>
        </source>
    </evidence>
    <sequence length="1473" mass="164734" checksum="D629022F7137B87D" modified="2020-12-02" version="1">MSTELSHQPDQKRSRTRILDAVRPGNQEHVETLITCGAGVNNSEETGKTALFHAITKENEKMVEKLIQCGAEINATNKDGRTPLFYAVKKENEKIVEELIQRGADINATDKDGKTPLFYAVKKGNEKIVEKLIQRGADINATDEDGKTPLFYAVRKQKEKIVEKLIDSGADIKRNDNNGRTVFYYAVVKECKEIVEKLIKNGADITETIANARTALFYAVEKENEKMVEKLFECGADVNEVDEDGKTALFYAVEKENEKMVKKLIECGAEINATDKDGKTPLFYAVGKQNEKMVYELLKSGADVNDTDEDGRTPLFYAVWNEHLEIVAKLVKYGAKTKISNKEGETALFYAVKKGNEEMVEMLINFGSDVNACAKNGATILFCAAQEENEKMVGKLIQWGADINITDEDGKTALFYAVIEKKENIVEKLIGCSAQVNASDIYGRTALFYAVNLNDEEMVEKLFKSGADINATDVHGVTALFYAVETGNEDMLEKLIECGAEIDANDNKGKTALTDKDGKTALFYAVDKENEKMVEKLIECGADVHATDKDGKTALFYAVERATENIVEKLIECGADINAKDNEGIPVLFHAVWKENERMLQKLIKSGVNINTTDKKGRTALFYAVEKENEKTVEKLIEFDADIDATDKDGKTALFYVVEKKNEKMVDKLIACGTDIHANDKKGRTVFFYAVKKGTAKIAKKLIECGADVNATNENGKTALFYAVQKENAKMVENLIRFGADVNITDNEGKTALFFLISHDEACLMARMLIEDGGAQVDVRDXYGRTPLFYAMTQSLSLAKYLLDKGATLHLNENCSVLTFFIEKCIFCSSEKTPNIHDGLKFLTDRKNVERDMIFEAIVSVAFCKTLYFKPGSCDIDVGSLSKLXTLAKEYASNNIFQVLFPVGKRKTIIEISTMIHEESHDKQLIGSGAAXEVIRRLIKLGANPNTTDSDGNTXLHHATQLAFXGVTXXSVMXXCXXLXKXNXXFHLTNHQDETPLLYCLXXTIXXXSREEEXXPAXXTQAAVCRFLVEHGSSVEAKTGSEESVLHLXIXLLHHXFFKRNXELRKXISEVALELAKVFLNAYTRQDVXPNAQDKDGNTVLHLWAKLELPXDEDYXSXVTEVYSXHELLKXILDHFXENKALLHVKNENGETPLHLCRTWTAVELLLDAGANPNDVDXSXRTPLLAAATNNESVYNRGLLFPDILMASDTEFWRTALKKGFNPWTADRHGEXVLSVLITSECXDLARALVDVACDXXNTXYPLVLFSLLTTICKDKLPNVHWKKDXAEXILSSTKCPVNGNDNEDSPLHYCCRNXVEVSKXLXXDEIQTTVHWXLAKLLRXXGADYRXPDTTGKTCLEIAAXCPALIELLKEPIDLDKFPXKXKNWKSVSKSHERQLQKVARHLESKQLEPYWYHKDHLACGSFGAVFAGINEKDGREVAIKRIEKIRMQRPEDKREITNLTALADCEQTFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZT9</accession>
    <name>A0A6P8GZT9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 182-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116286295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548621.1">
        <property type="nucleotide sequence ID" value="XM_031692761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZT9"/>
    <dbReference type="GeneID" id="116286295"/>
    <dbReference type="KEGG" id="aten:116286295"/>
    <dbReference type="InParanoid" id="A0A6P8GZT9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000382">
        <property type="entry name" value="zinc finger protein 35 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="633"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="880"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031548621.1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="129683" checksum="D5B7407CE3E413C9" modified="2020-12-02" version="1">MMARTKQTPVKSAQNESPIRKSGREKRKASTRGMAESKQSKKRKLRFSSQNDEKRSSTIKKPKAKGKPNDYLPPELRKAGLLAQQSVAKGKCFGPFRGHFSKAGKKTDNDCSLVCKIKGVDEVSYFFFVHDTDKEKCMWLQGMQSASSKMTQNMVAYKSAVGVCYEATCDINPGEELLVLYDDTYGGKKYPAYVESIPVQFVPQSGEGQLTVLPLNEQEVENADETQEDIAGIGTNNDDADDGTRDDDDDDNSDDDEEDFDNDVTDKDFSLEDDQAKMPTPKKKPKEVTKVTPSVNEIISMSLMDGTETTHKKYQCAYCAEEFSSHDAAVEHVTSQKCTSLLFTCDSGCGRTFDSNLSKITHKCNGKSICSVCDMEMSSYRELSRHMKEKRDDEDHKPRCTKCDIIFATRKKKYAHMRNEHASPDSMMACPVCHKLYTKSYLKEHLQSHAPDAFKCTLCQKQFSSKSNLRKHIHKHSPGYTPVKDNRRYEPRKRKHECSECQKMFDSPHSLEIHMRSHTGERPYQCELCHWKFSQKPHLKRHMKTVHCSDDEEKSERSLPPAEKPKTCELCNKVYSNSRVLRVHIQSVHEKERPHKCSYCEATFTQRGHLWRHKHTTHPECDEVQKKLQVRRYVCTVKECEASFCCQAELTSHLSTVHQMKWPFHCDECSATFANRSNLNKHRRRRHKCTPDGVEKPFICDTCENEFESHYKLTQHIRTHTGEKEFKCELCGQGFVQKSGLNKHIRCRRCPKIEGSPVRQISSKKYQCEICERVFPGPSDLKSHARTHTGEKPFECPECHKRFSQTGNLTKHIKYVHNKVKRPKDKPRQKNFFCSLCGKAFACPSSLAMHCRTHSGTKPFKCDTCQTAFSQLGNLKKHLKRWHDPVSGTVPKRKRVSKKKAKGQKDEATVENEVGELSEARNENEAMMSKEASQPNESNENSVNHESEVEEGDNNSNSQNDAEVMRREETAIASILTSITSDQSFANNRGFTPLNTPTPGFYISPLNSAISNIGPSFTRASIIMTSMSPVNSTVTVPAVMSQMQQNMEPHTQLAPVFVPSPIGSFMTVVPPTAMPQITTSSALAPITSVTTSSISSSSTILPHMHTILTSQIDPQHYVPHTTMNQVQTTDIPMYPFSPSSLFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2H9</accession>
    <name>A0A6P8H2H9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 14C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116287283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549808.1">
        <property type="nucleotide sequence ID" value="XM_031693948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2H9"/>
    <dbReference type="FunCoup" id="A0A6P8H2H9">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="GeneID" id="116287283"/>
    <dbReference type="KEGG" id="aten:116287283"/>
    <dbReference type="InParanoid" id="A0A6P8H2H9"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070453">
        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF43">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031549808.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="11737" checksum="74CE6ED2872F03D3" modified="2020-12-02" version="1">MPVESKHMKTMASTDYLSFGFAAVVALGGVLGYAKAGSTVSLAMGLGFGGIAAFGAVQTSRDPKNVWVLLVSSMILAGAMGSRAVRSGKFMPAGFIATLSLAEAARMGYRLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7H6</accession>
    <name>A0A6P8H7H6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116288732</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551421.1">
        <property type="nucleotide sequence ID" value="XM_031695561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7H6"/>
    <dbReference type="GeneID" id="116288732"/>
    <dbReference type="KEGG" id="aten:116288732"/>
    <dbReference type="InParanoid" id="A0A6P8H7H6"/>
    <dbReference type="OrthoDB" id="5984192at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551421.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="25360" checksum="367A61763ED05479" modified="2020-12-02" version="1">MCSVDYSYDEIQTKRRRRVKNLGVYEAERLIAQRKSPEMGNIYLVKWKGYSEFENTWEPEEHLSKSLLSYFQNPKPSEDIIQHYVDGLRRELLEALTHKLPEQTITLEFRHDVFKYLFHGKGEKRKEERNWTIYREEDFLRSQLPKNWNGIYDRHGDGVKIMFPIKMRTFLGMSPKGFHSSGNKIVEMPRLHTEKLSIKFVRITNTCRNEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7W1</accession>
    <name>A0A6P8H7W1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Partner of Y14 and mago-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116286446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548822.1">
        <property type="nucleotide sequence ID" value="XM_031692962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7W1"/>
    <dbReference type="FunCoup" id="A0A6P8H7W1">
        <property type="interactions" value="1802"/>
    </dbReference>
    <dbReference type="GeneID" id="116286446"/>
    <dbReference type="KEGG" id="aten:116286446"/>
    <dbReference type="InParanoid" id="A0A6P8H7W1"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="4">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="134"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031548822.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21797" checksum="2FEA32DBA385C8BE" modified="2020-12-02" version="1">MADGVDGSSSASSDKDSWIPATQRPDGTWRKARRVKEGFVPQDEVEKYESKGKQWLNSMPKLPPGLQEQPKILTKNQKKHDRKKNKNKESPGIQGQSMGSSLEEATKKMENIHLNSAQTKTTTAAGTVYTSNPNEVKQKKLKNLKKKLRQIEELQSKIDSGEVKNIEANQREKLAKKEEIVDEIEELERELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8A9</accession>
    <name>A0A6P8H8A9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphotriesterase-related protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116288786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551478.1">
        <property type="nucleotide sequence ID" value="XM_031695618.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H8A9">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="GeneID" id="116288786"/>
    <dbReference type="KEGG" id="aten:116288786"/>
    <dbReference type="InParanoid" id="A0A6P8H8A9"/>
    <dbReference type="OrthoDB" id="9998343at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00530">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017947">
        <property type="entry name" value="AryldialkylPase_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819:SF3">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01322">
        <property type="entry name" value="PHOSPHOTRIESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551478.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39047" checksum="D2528BB6BB5CAC61" modified="2020-12-02" version="1">MASGRVQTVLCVIAPEKLGRTLTHEHISLDFRPGLVKPPRETDLEKINCNEITLRNLGWIRQNPFCHQHSLALNEEPIEDMIQEVAEFKKEGGSTIVDNTVYGMQRNVETLKKIASGSGLNIIAGTGYYVDSFVSPEMKALSVEDMASTIVNELTVGVGNTGIKCGVIGEIGCSWPLTPFEKKSLQAATIAQTETGAPLIVHPGRNNNSPIEIIHFLQEAGXDINKTVMSHLDRTIFDHQDLLELARTGCYLEYDLFGMEPVNYLLNPAVDMPCDSQRIQEIKFLVSEGYEDKITISHDLHARHHLLKYGGHGYAHIQVNIIPKMLKRGISQEVIDKIQIENPKAWLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H959</accession>
    <name>A0A6P8H959_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289313</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552061.1">
        <property type="nucleotide sequence ID" value="XM_031696201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H959"/>
    <dbReference type="GeneID" id="116289313"/>
    <dbReference type="KEGG" id="aten:116289313"/>
    <dbReference type="InParanoid" id="A0A6P8H959"/>
    <dbReference type="OrthoDB" id="10410595at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552061.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13571" checksum="B2F7E2929FA44DD1" modified="2020-12-02" version="1">MAPGRKRDRRKGKEGNGSFSLNAKSAVIKGSSGSNTKKAKDKAVPKGKLKDQTTKWIEDVNKSFNELQPKLAEDHALEKIAGQREPKTCQKKEQRMQSLKSDITDEEVSNTITNMANLLEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB52</accession>
    <name>A0A6P8HB52_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289542</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552348.1">
        <property type="nucleotide sequence ID" value="XM_031696488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HB52"/>
    <dbReference type="GeneID" id="116289542"/>
    <dbReference type="KEGG" id="aten:116289542"/>
    <dbReference type="InParanoid" id="A0A6P8HB52"/>
    <dbReference type="OrthoDB" id="5983378at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="114"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552348.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22167" checksum="C4CC3858E9BB4649" modified="2020-12-02" version="1">MDSMNNNSTRRGANRRKSYTIDFKLKTLDLLGTLKEPKSKKLWVKVAERRGISKSLVVKWNKDRRKIQEQLALNKIKKNKGTAKPTRQRRQLVSGKVQGEKFPLAAQRVVVEFKLRRAKGCKISKLWLKKKMKEKIAVCYGKEQAEKFKASNNWFQRFKMRHGIAFRKRSNKKSAQQMMGGRLSNVSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBG0</accession>
    <name>A0A6P8HBG0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031552956.1">
        <property type="nucleotide sequence ID" value="XM_031697096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290107"/>
    <dbReference type="KEGG" id="aten:116290107"/>
    <dbReference type="InParanoid" id="A0A6P8HBG0"/>
    <dbReference type="OrthoDB" id="10066230at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552956.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29346" checksum="4260C73421415464" modified="2020-12-02" version="1">MAVVLIFACYSTAEVHVSKESQIADHCSVYATSDPLDKTLRKRCKHKHDKSCEHCEALDSVIKDIEGLIREVSFPSNDELDEALYIHGTAKRVIQSWKCHQLRSVRQDQARHDILDTINNSTVLIINDWAMKFIPHMYRESQSDWFXKRGISWHISVVYRREQGELQWQAFIHLIQSCSQDSPAIVVIMKHVLQTLKINKAYFRQDNAGCYHSATTILSCPTIEKATGIKIQGIDFSDPQSGKGAADRLAATAKSHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBQ3</accession>
    <name>A0A6P8HBQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein KIF25 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549925.1">
        <property type="nucleotide sequence ID" value="XM_031694065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBQ3"/>
    <dbReference type="FunCoup" id="A0A6P8HBQ3">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="GeneID" id="116287392"/>
    <dbReference type="KEGG" id="aten:116287392"/>
    <dbReference type="InParanoid" id="A0A6P8HBQ3"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000289">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF63">
        <property type="entry name" value="KINESIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="167"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="262"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549925.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="72077" checksum="5F56C9A2D79A02E4" modified="2020-12-02" version="1">MPEPADSMFKEKVQKLERLLRAREERIVALETENAMLYLKLAECQGSVRTSRFESSHFRRLFEAETGFRSNVKKSCKSLKKELKTLKTDLNELRVTVKEMPADFAKDLKKAREMTSQFGSEGLSSIEKIQSKLMETELKLDTALLKAATEKNRRMTLHNTLVEIRGNIRVHCRIRPLIVGIDSPDEASLGKPGTPSEQVVNYVDEETLSYVSIKSNGERIMQQKEFEHVYNDMDDQKKIFDDVKTLLTSLLDGYNVCIMAYGQTGSGKTHTMLGSHDVNVDIDSEELNKDEGIIPRAAKEIFKLIAERETLTETYSVEMSVCEIYNNDVRDLLAPNKNEKLNIITSSDGDTDIPSLVTKPVSNFNEVMNLVYFGMCRRHEDATMVHAHSSRSHLIVQLQVFMTTNQQPVARVSTPSSEAAPSPPGTPTRTRKNLPQLANHVSRSQSPAPKGRTMRQTRSKSPAPGSAAARSRSPSPSRSSTGTPPPISTTVKTKLQLVDLAGSECVGLSGVTGAALRETSFINKSLSALADVLGALAEHRSHIPYRNTRLTHMLQDTIGGNAKLLVMLCVSPAQKYITETLQCIGFGSRARQVARGPTKKRRPTSFVPNSSLSLGNELQSKNPQILAQFKQKVSKAQAAYSVLKKWQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCC2</accession>
    <name>A0A6P8HCC2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MIX23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Coiled-coil domain-containing protein 58</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116289922</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552731.1">
        <property type="nucleotide sequence ID" value="XM_031696871.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552738.1">
        <property type="nucleotide sequence ID" value="XM_031696878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCC2"/>
    <dbReference type="GeneID" id="116289922"/>
    <dbReference type="KEGG" id="aten:116289922"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031552738.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16962" checksum="ABB50A74D27EE843" modified="2020-12-02" version="1">MADEEKKEITQMSCADFSEFKEALKVLRLLDDKIMYKLNTSVPTESFAGEINGEAKCRELYTELLDGFKSRENAIKRCIHEVSNNIKSIKEQREANPDDFDLSKRLRSEQTKLRLMHSELSVEEVLKPGSLKKFNDKCWKSFKPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDI3</accession>
    <name>A0A6P8HDI3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proline dehydrogenase</fullName>
            <ecNumber evidence="5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031553736.1">
        <property type="nucleotide sequence ID" value="XM_031697876.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290773"/>
    <dbReference type="KEGG" id="aten:116290773"/>
    <dbReference type="InParanoid" id="A0A6P8HDI3"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="213"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553736.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="57847" checksum="933A40F53C9B63D7" modified="2020-12-02" version="1">MTDFNKYCVLILQRPIQTAHXYLKMSSFLLLRHSGRVKTCRQLFKFQQSFTIRSFHSNTSSFEEESGTVEFNNNHRVFESKKMGELARALFVLKFSSYEFLVKNSLPMMEFAKKVLGKKMFKSLMKKTMYSQFVAGEDYDSIKNSVDNLKAQGIGTIMCVPTEEDYTDADTDGFESREARFDRNSEVIHDCISKTETGTFSQMRVSAICSPSVLKALNDLLQPYQTQTYKPDGLSVRNFARGLDEATPSHNLVPQLTENQNKHLKNSLRRLDSFAKHCKSKNVRLLIDAEQYYLEGGNHHLILALQSKYNTWKPWVYGTYQCYRKDTLDRLEADLEMMSDDKFHFGAKLVRGAYRQQEKIRSIELGYEYPIYDSYEETCKAYNTALEIILRQVAYSPAEVMVASHNEESIQLATSRMIELGIEKRDAGVSFAQLYGMCDQVSYLLGHKGYEVYKSVPYGPVDTTLLYLVRRALENRDVTSRTEKERFLIWKEIRQRIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDI6</accession>
    <name>A0A6P8HDI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553123.1">
        <property type="nucleotide sequence ID" value="XM_031697263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDI6"/>
    <dbReference type="GeneID" id="116290257"/>
    <dbReference type="KEGG" id="aten:116290257"/>
    <dbReference type="InParanoid" id="A0A6P8HDI6"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027724705" evidence="1">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553123.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27870" checksum="585A9363A4F40E74" modified="2020-12-02" version="1">MAILHALLLVLSMAVLQPTKSEIIVPFSSEIFIPFVEINIFCTVKNEHFIGWFKDDSNIKIPVVPRRADAKGKPAVVIETRVGTLKKTCILIIPRGVGFRTATGRYICKGQRNQEIVVVQSRCEYTVLSKKPVVADRPSDHAIRPKRSMVSEVFVPFTEATLKPKFGLSIVCYIRNEHFIGWFKANSKIKIPVVASKADVKDEPAVVIATVSNKTTEALMIFPRGSPVSNAGKYVCTGGIHRAVVKVISKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDK0</accession>
    <name>A0A6P8HDK0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Thioredoxin-related transmembrane protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116288119</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550722.1">
        <property type="nucleotide sequence ID" value="XM_031694862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDK0"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="TMX_domain-containing"/>
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        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00085">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
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    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="chain" id="PRO_5027814508" evidence="14">
        <location>
            <begin position="25"/>
            <end position="261"/>
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        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
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        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
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        <location>
            <begin position="216"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022824"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS51352"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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        <source>
            <dbReference type="RefSeq" id="XP_031550722.1"/>
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    <sequence length="261" mass="29014" checksum="2922E0B31000A069" modified="2020-12-02" version="1">MAAAFWRFSLGTFLFSICLGLSSSASDGKVIELTEDNWKQILEGEWMIKFFAPWCPACQHVAPTWSAFALKGKQLGINVAEVDVTTQSALSGRFMVSSLPTIYHVKDGRFSVYDGSRFLDEFVNFVKEQKWRDNEPVPSWKSPGSFVMGALGILFKLSLFLKDIHEQLTTTYGLPMWASLAIFGVATISAGLILGLVIVYVSDFIFGRPGPPVIPNIPEAKPASKKDEDDIDKELKPEECKENKEAADQPVRKRKPQATTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFD1</accession>
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        <name evidence="5" type="primary">LOC116292028</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        </location>
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    <sequence length="176" mass="19654" checksum="02C72B0291B98A44" modified="2020-12-02" version="1">MYNLFITSRPQFTSQFQANNIVVEGADLHINCSAIGNPTPNITWVLLKNQAKEIKSQGVGFADLVIQNITRHQNGTYQCQATNNPNDYPVKTKTQVTVWYIPNITFLNWTVDEKTILFCQASGHPRPLIKWYYADGTQVESGATEITSGSRMVLKIPDSNSGLYGMYKCNATNEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFM3</accession>
    <name>A0A6P8HFM3_ACTTE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292101</fullName>
        </submittedName>
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        <name evidence="2" type="primary">LOC116292101</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        </source>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555209.1"/>
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    <sequence length="220" mass="24884" checksum="7CAC9A075AD8EEB7" modified="2020-12-02" version="1">MAFPQSSGCKILYHRLMLPDWLRKNAKWECACGGDELNLTIEPDNSDWDNIFRVKLLPQGQLTDDADITVKMVCGVILPEPQKPRDPMSFMISDGSFSVGIQLLDPNHDYAKSGPYKAVEGTSRRKRLTNPNTNVVTSQDLVTTSSKNNPDQFEITFKPSEFFGSAYCAIDDGHKLVAQYSDTLRLSKGLTFELYRFKSVERYTINYVEITIIQDSPNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFR1</accession>
    <name>A0A6P8HFR1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551420.1">
        <property type="nucleotide sequence ID" value="XM_031695560.1"/>
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    <dbReference type="GeneID" id="116288731"/>
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    <dbReference type="OrthoDB" id="10379049at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551420.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11851" checksum="CCB5EBC4EE874BAE" modified="2020-12-02" version="1">MKAVPTVVNTHNTTINAKSGKPPPLHPVNTESQQHSPTPTPSKPVCQCCARTAEKCDSIPYKLLANKPVYSEMSNALPPVKTQGTAKAQDMKLRIMEKNYDLKCDSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHB7</accession>
    <name>A0A6P8HHB7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Receptor-type tyrosine-protein phosphatase delta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116292125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555236.1">
        <property type="nucleotide sequence ID" value="XM_031699376.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292125"/>
    <dbReference type="InParanoid" id="A0A6P8HHB7"/>
    <dbReference type="OrthoDB" id="5989348at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="68"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="169"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="395"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="14">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031555236.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74485" checksum="0FA958265550CD50" modified="2020-12-02" version="1">MAGFRIFYTPEGGSQQQTDVGNVGHATLTNLRKYTNYDLXVAVRNTMYMGPVSSVTTIKTLEDVPDIGPQNTTATKINDTTFLVTWQSLTTDQSNGVVTKYEIFWSIVVVGGRSRRSLQEMFNTTTQATQYTLYNLRLCANYIVSVRGHTSVGPGPKSTINILTSQPDNPIDVQAESLTKTSIELRWKKPLPISLVVDKYMIEVKGSKSYWPKYSFSKTYTQNGARTNMVIDSLVPGTSYEFWVTASTECGKSQKSESSKKDTDIDNPVKPTGNSVTLKDKFDVPLWSVDPVNGPISSYQVIVIKGNKDVSDLPPNIGVYKDAKEFYVTAELKPNEIKSSFPVGDNKIYGQYKNVPLDKGKTSTIVERAITEHQGNVYAGQAAVVATIEVTQDPPAFANSTIWALEDDEITIGCYTSGHEPIKYLWTKLGSPSLDSFEARASGDDLIIRLKSDKEFGIYVCTATNSERTIVYRINRVELKKYITRKPSASERKAKEVVPYVIPLVLIILGLIICIAYLVYRLKKEKQHNESIRKKIKNKKDETGITNDVMVLHTNYQDNVIKNSKTPETTTADEIETSGYMELQPRRSSDTVYQSIQQPANRPRKSETQHTRGMXGHEQYMDLKPRANTEYETLRHKENAPGQDYEDVGQDFRRNIYSNDTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIE2</accession>
    <name>A0A6P8HIE2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TNFAIP3-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116289536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552340.1">
        <property type="nucleotide sequence ID" value="XM_031696480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIE2"/>
    <dbReference type="GeneID" id="116289536"/>
    <dbReference type="KEGG" id="aten:116289536"/>
    <dbReference type="InParanoid" id="A0A6P8HIE2"/>
    <dbReference type="OrthoDB" id="6066489at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882:SF11">
        <property type="entry name" value="HDA1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552340.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="33133" checksum="1D4EFEF82D4FB77C" modified="2020-12-02" version="1">MMASSNVKARCSKCDEIQRLYLAVLEDKQAILVRLQEEQERVKKLSKEIEPTERKRRQEGERTRTEESTNISMAMAVNRKWKEEYEQLREKYKTDFRKLQEEISSLNHKLEESNIHVLTLEAENMRLAQALSGEDVSTGTKRNNEENELIKAQMQAYKDDFSFERRDREKAQSEKESIQEELKSAQEIIATLVKEIEVFKVEHKKDQEQMRQIINQQNLARPQLQIIYPVVDPSEHEQHTQWRRQQQRRGILSRGSHIAPPSAFYGGDVEVDQADGPKSEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIG0</accession>
    <name>A0A6P8HIG0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vascular endothelial growth factor receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555631.1">
        <property type="nucleotide sequence ID" value="XM_031699771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIG0"/>
    <dbReference type="GeneID" id="116292444"/>
    <dbReference type="KEGG" id="aten:116292444"/>
    <dbReference type="InParanoid" id="A0A6P8HIG0"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="153"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555631.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27767" checksum="A979AE482959EF96" modified="2020-12-02" version="1">MKISPKKRFAVSETVGLSFLKFMEIERNEGGTYECQATNNPVEPPVTSKINIFVIYFEHSSTLLDKNGEAQIVEGEDLNITCAISPIWLDNVTWVHVPTHEFLKLGSVKVNSGTLAIRNFSRSQQGKYQCQAYDKKDGILGIANVFIKVMYKPEIDEILSSKHNISRFGDTIYLRCVARGVPVPNVTWYGLNGKIRVNGTSYYPGTSTLRLLKLNTLDFGIYSCLAKNRYGIAWHNVTVTKYCECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJV6</accession>
    <name>A0A6P8HJV6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556101.1">
        <property type="nucleotide sequence ID" value="XM_031700241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJV6"/>
    <dbReference type="FunCoup" id="A0A6P8HJV6">
        <property type="interactions" value="2097"/>
    </dbReference>
    <dbReference type="GeneID" id="116292891"/>
    <dbReference type="KEGG" id="aten:116292891"/>
    <dbReference type="InParanoid" id="A0A6P8HJV6"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000014">
        <property type="entry name" value="Mitochondrial-processing peptidase alpha subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="78"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="233"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556101.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59454" checksum="40C580198726F67E" modified="2020-12-02" version="1">MSYLYRKIASNPLCSVSRVLRGYPIVFVPSRLCANSNVPPLDQPIVKLPPPPPGVVEHVKWTRDHHETQVTTLENGIRVASEESFGQFSTVGVVIDAGSRYEVDCPAGITHVLEKLAFQSTARFPNQDDILQILEPVGGMADCTSFRDAIVYGTSTFTSGVPMAMEVLSEGILYPNISEQEVEEQKMTVQFELENLEFKLDPEPLLTDMIHAAAYRDNTLGLPKLCPPDSLGKINVKEIIQFLQRYYLPSRMVVTGVNVDHEQLIDLTRQYFVNKKPTWMADEDVVIKPPDKSIAQYTGGIIKEHLNEPRINPGPSPLPELAHISIGLESCPYVDEDFFAFTVLNTLMGGGGSFSAGGPGKGMYSRLYLNVLNRYHWIYSATAFHHSYADSGMFCIHASTHPSRVHDLAQVIIREYFSLASGLISESEVARAKKQLQSMLMMNLESRIIVFEDIGRQVLGLGERRTAKDLYDCIEAVTIDDIKRVSSRMLSTNPSVAAFGNLSMLPKFESFQQAFANKGVFPGKSLFFNFRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKC9</accession>
    <name>A0A6P8HKC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="22">DNA repair protein RAD50-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116290191</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553055.1">
        <property type="nucleotide sequence ID" value="XM_031697195.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HKC9">
        <property type="interactions" value="2559"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116290191"/>
    <dbReference type="InParanoid" id="A0A6P8HKC9"/>
    <dbReference type="OrthoDB" id="6021015at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="20">
        <location>
            <begin position="637"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="201"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="395"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="465"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="582"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="751"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="850"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="977"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="22">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031553055.1"/>
        </source>
    </evidence>
    <sequence length="1320" mass="152816" checksum="2C361D4030431A2D" modified="2020-12-02" version="1">MSSIEKLKIQGIRSYSQNEPAAIEFFKPLTLIVGSNGAGKTSIIECLKYVTTGDLPPGSKNSYFVHDPKVAGEQEIKGQVKLMFKDITGKTVVVTRALISQQKGKKLETRSLESVIKKDIHGERRSLSSKCAEVNHEMISMLGVSKAVLENVIFCHQEDSNWPLSEGKALKQKFDEIFAATRYIKALEAIRKLRLEQGRXVTKCETELKYLKENKDKAQEIAEQLEKSQGKIEATRDSIXKISRNLEPVEIRLTEIEQIAVEVSQLQKEKELLMAKKEQLADMEQDLLQNITDVFTGSTEELQGIYQDFQNKIKEKNELLKQKENEHQHLVAKQQELSNQKSSILQEQGKLEQQAQRHQTNLGDRDXMVSTLANYYEIQGYSKTPFTEAQVDRFIEDLKKNYANIVEETKQQKELFKNKIEVVQKKIDDIKRSQAEYGETIRLKKXLMGDNQRELKAIGQELSNVNASANRLKSLDAELQXAMKELEEANELGNVDEMNAEIEKLQNDKRQVDGELSRLREEQQTMHFHSTTKTKLDMLIKEKIEKEDNIQKLMNKHDEDIKTIIGGTGTSESLSDKLGQYLRNKGKELQDTRNRMQRIKQAQSAKEANKKNIEDQLKRKVDQAATYKQQLKDACGENDYNTMKEQLSEQISXLRNEKGLFSSIEKIYKKYIKKLQEESVKEEGCPLCHRCFDSSKQIKSLIAELNEKVVHLPAKREENDILLDQEERRYEKILKLGPIKENLEKIETSEIQEAKSRLADISKDLEKMEAQIMELEDVYSLTESEEMTARQMEPDLREVENYKRSLKDLDKNISLYQSQLQGIAPGRTMQAVTNEITDRQDRSETLDRHIDRRRRALTQLQRQLTTLTSNVHDLKSKKLKLNEQLQRRTHLEEQKAELTXKNDAFAREIKDAEAQSQPIQVMLDEEERKKHNIVVAKEAMEEEKRILLTDMKNNGERLSEKISEIKRYTSQGGESALQDNQERLKAVEDREKQIHRKKLGITEIIDSFKEDISKQEIKSRDIEDNLKLKSTQKDIQNXENKIESVEGKLDQYXDPRSLNSERSRLHRQLDDLHKEKSHLEGRQKGFEDEIRRYQTELRSNMYNNAEEKHRQKIIEMKTTQMASVDLDKYYKALDRAIMKYHSLKMAEINKIIKEYWINTYKGGDIDTIEIRSDEEEGSGASKARRTYNYRVVMIKGDIALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIFTLDEPTTNLDESNVYSLADQLATVIRTRQXQRNFQLVVITHDEEFVDTLGRADFVDYYYKIYKNDSGFSKIAKQSVASLQREASYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKN2</accession>
    <name>A0A6P8HKN2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293621</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031556934.1">
        <property type="nucleotide sequence ID" value="XM_031701074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293621"/>
    <dbReference type="KEGG" id="aten:116293621"/>
    <dbReference type="InParanoid" id="A0A6P8HKN2"/>
    <dbReference type="OrthoDB" id="10268349at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028439094" evidence="1">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556934.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24568" checksum="5C6F276453CE5846" modified="2020-12-02" version="1">MSIEAKRLYAVSAVLFLALHMTQVSECETSIEAIDEEIPDVICASPGIFCWCRVSNHDSEVLYDYKDMSDEVQFSYPNDTNGELLCSSTCLRKCASLFQDKKQMCNRVNNGYNSSYQSXGCYSQLGEKPDFASKPWTQLSTPEDLCCETSKKGCETEYGPGYVYVKEHNMCLKEVYDGCIFNVPFNSKKPPVCCLTNPSTGRNTTYGCQPTHTCGLTVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLL8</accession>
    <name>A0A6P8HLL8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor IIIB 50 kDa subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116290583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553515.1">
        <property type="nucleotide sequence ID" value="XM_031697655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLL8"/>
    <dbReference type="GeneID" id="116290583"/>
    <dbReference type="KEGG" id="aten:116290583"/>
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    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
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    </dbReference>
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        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="5">
        <location>
            <begin position="73"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031553515.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="61189" checksum="609633CD962B7B56" modified="2020-12-02" version="1">MNKICTHCGASAIEVDDEGKLEVCSNCGVVCNEGSFHNDTRGAVRTFTSDHSSFSGGAGNWRKKEQHRVKNKHFVIAKRCLEGQAERLRLSKEYTTQIEEKLKTLYEEQLYKGLPRNRKAFVGACVYIVCRQNDMVVTLRNVAEAARCDVSILARCVRMLTDAMNVRIVAIEPDEVITNILSQFEIQDPSTKKLVHDLFQFCSKTMISLGKRITLTVMALVFMVIEGENKKALSRKKIAEVCRFNTVTHEYVQRFVRQYREELFKLAKKIPWMSSELTPKKVPKFLKEILEYYKDCEDFHNVDFKPQWLERKDLKEKEKMQKIEKAENRIAACQQRCGDLEIDDNISLHKFCKQICRSSTQTSNSEVSFLPSSASVLPTESELGSEDKQKHCKEVPSNSSENPASDVSSLPSDLSTATELVSEDDQMDIDHVCCPHCCVNKQDCPVYQRTGSSRFCKLDGCDMIIECLLRKGYSRQRLIESNPESLFYSENYNTDSEAEREELDDGDICDEDIHLYIKSDHEIAQTQMLKINVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMF8</accession>
    <name>A0A6P8HMF8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116290861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553835.1">
        <property type="nucleotide sequence ID" value="XM_031697975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMF8"/>
    <dbReference type="GeneID" id="116290861"/>
    <dbReference type="KEGG" id="aten:116290861"/>
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    <dbReference type="OrthoDB" id="5978338at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031553835.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28282" checksum="FB7DF91EBD0B41AF" modified="2020-12-02" version="1">MSNDSVSGSCVGVSAPRYLSILTTTVSLGLTLVTVPGNSLICYAILKDPFHELRTPFTFLILSLAMTDLLVGILMDPISTVFHLSEALKIDLVDIRVLHISYFILSTASILSLGALTIDRYVAVIYPLKYKSYLSTKKCIYLSLVIWLVSIGLSMVYFKFGYIFYSLIFASTAVLLTFLVLLFVYVSIFNRLRKQVRSLSRQRASSTQANRVNKKKISSLKWEAKVTKALVLVLLAYILCFAPACIIIYVLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMU5</accession>
    <name>A0A6P8HMU5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEP domain-containing mTOR-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553967.1">
        <property type="nucleotide sequence ID" value="XM_031698107.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HMU5">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="GeneID" id="116290985"/>
    <dbReference type="KEGG" id="aten:116290985"/>
    <dbReference type="InParanoid" id="A0A6P8HMU5"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
        <property type="entry name" value="mTOR-Rac_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="125"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="304"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031553967.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43798" checksum="6080132040A02EBC" modified="2020-12-02" version="1">MERISSKFVHILIFSEYLRTRLHSERDPPIIKDRRYHLRMYPTCFVGKDLVEWLVQRGEAPSRFAAVQCMCVLQDHNLIHHVCDDHVFKDDMLFYRFRLDDHSLPITHDISLVLKGYNISQRIKSDENSIVKHQECEDXVYRNCFVGSALVDWMVESGETPDRFGAVMLSRELLELGLIKHVTDDHHFKDDPKLHFQFVIDKIISKKLCDGMSLLESGQIIAEPGSPLIERKNGKHLPPLIFAKRSIPVPLSNRGNNDNSCSPESPDYFPSSCSPENSSPRPVIVREITVEELLDSTGPYTMKAIKIMSDSVGFGFVVRGKEPVYVQTVDPEGPAAAAGLRVRMFIHSVNGKEVLHWSHKEVAKEIMRGQNVVDLIVMTHFRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN62</accession>
    <name>A0A6P8HN62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salivary glue protein Sgs-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554100.1">
        <property type="nucleotide sequence ID" value="XM_031698240.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291118"/>
    <dbReference type="KEGG" id="aten:116291118"/>
    <dbReference type="InParanoid" id="A0A6P8HN62"/>
    <dbReference type="OrthoDB" id="5990641at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028130610" evidence="3">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554100.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="46177" checksum="1B5A386CEF805107" modified="2020-12-02" version="1">MNILFALVGLVALLVFSVDSSPLNRISKESTIRIVKREAGLDNNSTLPQGNSSGLCNTTDCNNSTSNVTSKFNLTNSSNVTATWLNLTQVCSENKTGITLQCNGTTLNLTKHCEDTKNGNISLYCVNETTSNNNVSLSSNATLFNATIMKPNQTLSNASMNATAPNVTSVNETVNGTVGLANTISLSQSVSLSVTATLTASPSLSVAVTSSYSGSASPTLVSTSSSIQPSSTSSVAPVSSWSVAATTVAVVDTTTQSTTTQSTTTQSTTTQSTTTQPTTTEATTAQITKPETTTTQPKTTESTTAQPTTPKATTHGAETTATKTEEATTLKKETEHVTPGSTSGTDEKDKSTAATTMKSPYNNAEIISFQNVKFFYVNILIPVGAGVCGALLIAFSVLLFXCCRRRKLKKVRYFGKPRKGHTRSSMDHMNLLAVSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQB5</accession>
    <name>A0A6P8HQB5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031557298.1">
        <property type="nucleotide sequence ID" value="XM_031701438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQB5"/>
    <dbReference type="GeneID" id="116293932"/>
    <dbReference type="KEGG" id="aten:116293932"/>
    <dbReference type="InParanoid" id="A0A6P8HQB5"/>
    <dbReference type="OrthoDB" id="5979271at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557298.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20893" checksum="09D0393F640C393B" modified="2020-12-02" version="1">MADTTRVKRESKFPVRYMQEFSSDFASKQRKSSKKDNNLYDVVVTEVDKSKKRIKIHYVGYSTKYDEWKSFGDGASFPFVRHEKLNIPSADSIGDRQEIFHGQLYREIKRKLFSGRRDDPAVRIELRVEPDVFEGGLATVVRGIKKDKRLFTGYHPTDSLTISLVKSGMSAFLMVMETLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQJ6</accession>
    <name>A0A6P8HQJ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554945.1">
        <property type="nucleotide sequence ID" value="XM_031699085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQJ6"/>
    <dbReference type="FunCoup" id="A0A6P8HQJ6">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="GeneID" id="116291864"/>
    <dbReference type="KEGG" id="aten:116291864"/>
    <dbReference type="InParanoid" id="A0A6P8HQJ6"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22088">
        <property type="entry name" value="F-box_FBXO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048003">
        <property type="entry name" value="FBXO8_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF372">
        <property type="entry name" value="F-BOX ONLY PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="1">
        <location>
            <begin position="83"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554945.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33801" checksum="F5D0D0FC477F11C9" modified="2020-12-02" version="1">MGQFHGILARKESSRSKEALQTFPDLDNLPPELAVAVLSNLNATDLCLAACVWDHLANNDLLWMSLCRTTWKYVPAYKEMRKSNLPYKSLYLLLDDGTCLFNVYPKEGMLFFLKHSILEDSVEDIALFINGASVFRSDAVRDYLYDRRDILEELIKLQTYSNMFLPEAMRKLFDLIQPPEERGEYIDTLIEVFSRRYLECNPTCELSQDTLVILCNSLLLLSVDLSSPKVKNKMTKREFIKNLRGVVHPSSVDFIGDLYDNVYLQGHVAVPKGKCLKIQTFPFVRPYGNIFFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR06</accession>
    <name>A0A6P8HR06_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116292014</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116292014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555107.1">
        <property type="nucleotide sequence ID" value="XM_031699247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR06"/>
    <dbReference type="GeneID" id="116292014"/>
    <dbReference type="KEGG" id="aten:116292014"/>
    <dbReference type="InParanoid" id="A0A6P8HR06"/>
    <dbReference type="OrthoDB" id="5989888at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031555107.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39134" checksum="CFA7943010B25B5A" modified="2020-12-02" version="1">MVNCCVPECTNYSTKTKDVSYHKIPKDLQIQKAWISRLRRANLPPLKNCYVCSEHFEDGCFESDLMEQLIGEKRKRRLKADAIPSIFNFSTIPSKRRATTENRIRRQRQKETLDNLLTPTTHALDEMVEESDMEVSFDETPSNKRDFGVQCCLDEKLSIRKSTSTQTENVDVSVETSDACIQVEGNSTFEQLNSILHDHPYSYTAPSVPMSVSPQKSCKNDVSPQKSAKSCGSFPLSDEEVNLFSSDEEDEYIISSQETNSSTDKESEPEYHFDTYIKEPKYLVFAACLGELFRFCINCGSIVTDTNITCTGSMVTVKTICMKGHNCLWNSQPLINRAPVGNLLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR28</accession>
    <name>A0A6P8HR28_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="32">Neurogenic locus notch homolog protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">LOC116294546</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="32">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOTCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558031.1">
        <property type="nucleotide sequence ID" value="XM_031702171.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HR28">
        <property type="interactions" value="1357"/>
    </dbReference>
    <dbReference type="GeneID" id="116294546"/>
    <dbReference type="KEGG" id="aten:116294546"/>
    <dbReference type="InParanoid" id="A0A6P8HR28"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="CDD" id="cd21701">
        <property type="entry name" value="JMTM_Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000327">
        <property type="entry name" value="neurogenic locus notch homolog protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008297">
        <property type="entry name" value="Notch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024600">
        <property type="entry name" value="Notch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010660">
        <property type="entry name" value="Notch_NOD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011656">
        <property type="entry name" value="Notch_NODP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF10">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2 PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06816">
        <property type="entry name" value="NOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07684">
        <property type="entry name" value="NODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002279">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01334">
        <property type="entry name" value="DUF3454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01338">
        <property type="entry name" value="NOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01339">
        <property type="entry name" value="NODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0010">Activator</keyword>
    <keyword evidence="15 25" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="23" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17 24 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 26" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 28" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028417943" evidence="28">
        <location>
            <begin position="22"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="467"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="505"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="543"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="582"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="657"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="695"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="736"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="780"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="818"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="855"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="893"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="933"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="971"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1009"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="29">
        <location>
            <begin position="1047"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="30">
        <location>
            <begin position="1172"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="25">
        <location>
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    <sequence length="2157" mass="233395" checksum="D8726BD0E2420FCD" modified="2020-12-02" version="1">MWRVLNSFLYLWILLNYKAAGYYYQRLKSYEGRTCKPRLHKKVYHRFCKDVTPCRTIKDCTEHNDRCICDEDCGNICFDPTSKCSTGWCQNGGSCSIVNGSVHCSCPPNFTGKRCEVDVDECSTLSNPCKNGATCTNVDGGYICRCITGWEGADCSINVNDCLETPNNPKCLNGGTCVDRVGSYRCNCPPNKAGLICQFDNECASNPCNGSATCVPSPFGKANCLCSHGWTGPNCDVDIPDCNVAQSPCYHGGTCRDVPGSFVCDCVPGFTGSRCETNINECESNPCQNGNCLDYYNQFECVCFNGWTGKLCEVEINECDSMPCQNGGQCHDKLGEYSCTCLYGYEGTHCEIDIDDCASSPCRNGATCNDLVGKYSCTCPLGFTDTNCQTNINECATSPCQNMGTCVDGINGYTCNCRGGYTGTNCELEIDECHSSPCQNGGVCRNVVNGYLCICPPGASGDHCENDPNDCPVGACLNGGVCIDGMNNYSCKCHPGFTSSNCGVEIDECATSPCRNGGRCIDGVAQYMCQCRNGYTGRDCETVIDSCLGHTCRNSATCSSNSPYTYTCNCKPGYSGKYCEEDVNECQARPCVSGTCVDGINGYTCRCNPGFTGDRCHININDCQSSPCVQGGTCIDGINQYTCSCPKGFTGERCEIHINECSSNPCTHGGTCVDKIGSYSCYCPPGYTGTKCQQPLNRCLINPCRNSGTCKRTGRDLSDFYCACPDGYNGTICDVMNISCALAQSKGAICLNQGTCVDNSKGIQSCKCKPGYTGSYCETNINDCASGPCKYGATCYDGIANYTCTCRNGFKGRNCDININECANNPCARGTCIDLIDDFLCSCPKGYVGSRCEINPNDCFLNACFNGGTCRDGIASYQCSCPSGFTGSRCEINVDECASNPCSGLGTETCFNLVDNYHCXCKRGFLGKNCELNINECLSFPCQNGGTCKDGAGKYTCLCKKGYSGNNCERQVYSCNDTPCENGGTCRSVEGSYECDCKQGVYGQQCEWNKDDCLSDPCKNGGTCVDGYDSYTCNCPEGFTGNNCQQIINECASNPCRNGGSCRDLVGSYKCDCPEKLIGKNCEVLVKDSCPYSDCAKKFDGGKCVAKCNNYECNWDGTTCSLGIEPWSNCTAVTNSGRPCYEVFENGVCNQECNTGTCLLDGFDCKKPTPSCPRNKYCAARFADTRCDKECNNKGCLEDGLDCNIQVPKPAKGTLVLVLLVTPETFMKGSREFMRELSRVLGXIAFIKKDKDDRPIVLPYPLPPSAPVPIGRKRRSAESAEYVRSSRNRRASSEKNGAEVHVTLDNRGCESDCFQDVGNAARFLGAKASNNKLDLPYPVYAVDSQEKPTVSPKPGFEPSPLWIAILCVGIPLFIVGVLAGGKRMYTKLWLPEGFPRRLIHQRRSQRRDPVGQEVSMRSMNKSTTDLEEEGAAGGSALSRSDLTPPSEARDPKRVKLDDEDELKRGGSVEKDTRKWTRLHREAADVNVRNCSSLMPPQKCERGAEVQDVDARGPGGFTALHLASCRGTFLDGCIDDDKDSDDSGGVMVSDLLSMGASYGAKTDESQETPLHLAARHSRADAAKRLLDAGADPNSRDRLGRTPLHLAVGSDAQGVFQILLRNRATDLEARMDDGTTPLILAARFDLVDIVKDLIKAGAKVNNIDNQGKSALHWAAAVNSHEVTAELAKNGAKKDLQDDKGQTPLFLGAREGSLEAVRILLLNYANRNIADNMDKTPEHIARHKMHHDIVQLLKDWSLGCNSPKAAPAXTSPPDQQKSPHNGTASPPCTELQNGKSVITHFPVTTSSTRAKASSTNSDHARGARAKTTANGGTKRKRKRQPRKDEEPVAENYSNSRKPSDGAAAYSPQGHVKQPSPCSSGPTFSPNCVSSVMNGFSPQGSSGTGISPSNSTTLSPPQDTNSPPVFSDSPFNDVLANEYGLEEFNGLDFDDIHLNETELSTNFGGTECGVDSGSPNLHDSLSMSCMLPVTAIGGETINNTSDCMFYPTQQRQQRREYPSGTRLYSAQSSPNLACTVESEPRQISIVQDMDDMSSVAHCVQNGFPNGHRTVQACAMTNGVVMPRRKNSSSSSYTNNQLYHHMQHPNNILYNENYPTPPSVHSYSISYDSPQKLPVSYLTPSPDSPEEWSSSPHSLNSDWSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTF8</accession>
    <name>A0A6P8HTF8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116295106</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031558696.1">
        <property type="nucleotide sequence ID" value="XM_031702836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTF8"/>
    <dbReference type="FunCoup" id="A0A6P8HTF8">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="116295106"/>
    <dbReference type="KEGG" id="aten:116295106"/>
    <dbReference type="InParanoid" id="A0A6P8HTF8"/>
    <dbReference type="OrthoDB" id="5958694at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000067">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
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    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
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        <property type="entry name" value="ShKT_dom"/>
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        <property type="entry name" value="TSP1_rpt"/>
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    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF901">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ASTACIN"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="12 13" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="66"/>
            <end position="264"/>
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            <begin position="387"/>
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            <end position="584"/>
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            <end position="622"/>
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            <begin position="627"/>
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            <end position="701"/>
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            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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            <begin position="11"/>
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    </feature>
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        <location>
            <position position="160"/>
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        <ligand>
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            <dbReference type="ARBA" id="ARBA00004613"/>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022536"/>
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            <dbReference type="ARBA" id="ARBA00022656"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU361183"/>
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        <source>
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            <dbReference type="PROSITE" id="PS51864"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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            <dbReference type="RefSeq" id="XP_031558696.1"/>
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    <sequence length="701" mass="79567" checksum="0D5692B35785EC3B" modified="2020-12-02" version="1">MAHLEKRKKALRDQETKRSKEPDVFENIEKDNEGKKIEGLYQGDIIEDEDLEKLLHLPNRTRTKRNAIRSRKRLWQSRIIPYKLTPDMMHIKKNLFIAFAEYHKHTCLRFVPYQPGVHGNHIYFNRNTGCSSKIGRHYVAPVGQPISLGSGCNFPGTIIHELLHALGFWHEQARADRDKFVSVKWENIQTGFDDQFSKYDWNSIDAMGQLYDYESIMHYDRTAFTKNGKPTIVAIGNENKKFGTQNHRLSEADIIEINALYDCKTKKLGWTKWSDFTSCDKNCFKSRERYCFHSGDPKSCGGNVNVYGIEKDSKKCTRMECLARNSISGHWGNWGAWTACSASCDDGVRSRTRQCNNPAPSKYGKPCKGEAKEEEICTIKRCHMGKDDTTFDDSSHPFGMWKNKVGTKLQWIRHTAFTKTLDTGPMSDHTTGKGYYLYMESSSPAKHGDQAILTSPTLTSSKTGSQCLKFYYTMYGNTMGSLEVRLHRPGSPTRNIFFKKGNQGTPWHLGTATIQANEGFKLEIVATVGSVGYSDIAIDDVYIDPGKCSCQDEYISCAKWSASGACNTNTVWMKKHCPKSCQVCGVCKDLNPVQCPLWAKRGECQKNRIYMGDNCPKSCEFCNAPSCNDNPKFKDQCPLWALKDECTLKNKKWMQANCPKSCNVCVCGDNNPSCSKWAKADQCDKNPVYMHVNCKKSCKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTZ7</accession>
    <name>A0A6P8HTZ7_ACTTE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296049</fullName>
        </submittedName>
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        <name evidence="3" type="primary">LOC116296049</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <begin position="1"/>
            <end position="157"/>
        </location>
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        <location>
            <position position="164"/>
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    </feature>
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            <dbReference type="Pfam" id="PF16977"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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        <source>
            <dbReference type="RefSeq" id="XP_031559864.1"/>
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    </evidence>
    <sequence length="164" mass="19985" checksum="17319E6E4AB7993C" modified="2020-12-02" version="1">MQGEVSQYRVIRNFCIKTIHRTIYQYWPTGQYCIYGKPDKQSYGWIEMYDDRQSNFFSVWPFANQRYYHWAIRLYFFCQTSGNKKIPISLPITKPFYLLPYGSRDCQQVKWMVATTEWIKYHTHDYSYSYYQKHGTVPNHKLGDWNHNGITMFYCYYESKKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUZ3</accession>
    <name>A0A6P8HUZ3_ACTTE</name>
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        <submittedName>
            <fullName evidence="5">Cleavage and polyadenylation specificity factor subunit CG7185-like isoform X1</fullName>
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        <name evidence="5" type="primary">LOC116295457</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="TTC14"/>
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    <dbReference type="PANTHER" id="PTHR23184:SF10">
        <property type="entry name" value="ARGININE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G12120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
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        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
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        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
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        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
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        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
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        <location>
            <begin position="746"/>
            <end position="801"/>
        </location>
    </feature>
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        <location>
            <begin position="808"/>
            <end position="934"/>
        </location>
    </feature>
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        <location>
            <begin position="935"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559128.1"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116287" checksum="A43D19356A6C36CB" modified="2020-12-02" version="1">MDFTDIREDELVSSLGVDFEHGRRHMGPRQGFRPGFGPRPPHGPMGLGRSPHSNHPPGMMQGPPRQPEPYFGHPGPRGHGPLMRAPNMGPRGPPQSHGMHGQRPRMQGGPGSVPQMRPETGMGRGRKRTQSGPKPSQTPERQRKGSKGGGPDERQEQTTKEDGAKKTKMDADQTKNKDTEAHESDIDEDKLLKSDDEGEEPAXQEDLDAVSIHGDEDIDDIDKEVKSGNPGKSAVKNEAAKKDDSDSEGEKSKRERFPSERPKEEKPRRPEQGKPDFKRSDFRRQDNRNKKDFAFGRGRGRGGPDMQRFGGPPMRMEPPRGPMMRPGQPGRPGFPGHMMHQGHPGYPGHPGMQGPRFDHPGLPPRMMHPPEDPXRHGPAPFPAGGSMSGPSGPPMQMKPPQGKNIHINPHFKPGRGMPEGPPGGRPGPPMHSGPDGPGPRMMHLHPNQGPEQLQPGPPMHGPQHMGESPGPNMRGGPQRMEPMRPMDSEPRPMHDVGPPGPRDQRGPHDGPPRMDHGPRIPQGPQFRGQLPGGPNMAPPHHGGPQGMQQGPRGGGLPPGGRTLSPPRPQAHQVMPGMHPQQSVGNLPPHMQPHGQQGMPPQREPQVPYSEADRIVVGNRVIVPNVDQPNPMLGHMPAGFGGQPNAAPGAAVAAAAAAVAAASRQQYPFPQQFPFDYSMYSANWQQLLQQRDAYAAAAAYNMESERNRAETPQQKTNFSMGLAATGLSTRHTKKRRHRYTDEESVGSDLSSSRSYSRSPSRSYSKSPARSWSRSRSLSLSPSSVRSSRSRSFSRSLSGSPQRYSRPLKSRYDRNDRPARSYDRGRARPPRHQDRPRDIRPRERPPRMERDNRPRDRNLPHDRDLRDREREREREREREQEREKLRDQRRERERERDRDRDAKSHERDRDRNREGRDSGRDQDRSRRGRGESKHSESGSSKRIVVGPSESKSKSSSSANPDSKASRVVVTKGSSGGKPTNRVVIGSLPDLITPSRVKELLAGIGPIQQLKMSTTKHKALVTFEKNENALACRRKFHRTVVDGSQVTVDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVF7</accession>
    <name>A0A6P8HVF7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferroptosis suppressor protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Apoptosis-inducing factor homologous mitochondrion-associated inducer of death</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">p53-responsive gene 3 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC116293362</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16 17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Putative FAD-dependent oxidoreductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>menadione + NADH + H(+) = menadiol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:69695"/>
            <dbReference type="ChEBI" id="CHEBI:6746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28869"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:69696"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>menaquinone-4 + NADH + H(+) = menaquinol-4 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:74079"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78277"/>
            <dbReference type="ChEBI" id="CHEBI:193091"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:74080"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>phylloquinone + NADH + H(+) = phylloquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:74075"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18067"/>
            <dbReference type="ChEBI" id="CHEBI:28433"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:74076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + NADH + H(+) = ubiquinol-10 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:61984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:61985"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>6-hydroxy-FAD</name>
            <dbReference type="ChEBI" id="CHEBI:60470"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556640.1">
        <property type="nucleotide sequence ID" value="XM_031700780.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556641.1">
        <property type="nucleotide sequence ID" value="XM_031700781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293362"/>
    <dbReference type="KEGG" id="aten:116293362"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000006">
        <property type="entry name" value="apoptosis-inducing factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="13"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031556640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031556641.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41514" checksum="D794E65FB4F22ED4" modified="2020-12-02" version="1">MGTSASKPRYQCHVVIVGGGFGGINAAVQLDSYCQVTLIDPKDAFHNNVAALRGVVEPSFIKKTLIPYENALQHGTFIKAKCVSVHLSLKKVTLSDGQEIQYDYLIFACGSSNPFPGKVPLGMSKDDAQKLYEDLAKEVKNSKKIAIIGGGPVGVEMAGEIACDYPDKQVTIIHSRDRLIDERMSEKFLKKVHSAVKSMKITTVLGEKVAMEELNFDGQKSWVSGPITLTTDKGTSIEADLVLRCTGFKVNADAYRSKLSDKMDHNTGTLKVNKYLQVEEMDDVFAVGDCNNTDEMKLAYVAGVQGELVAFNIKQLNENKKLKEHKLSRPMMVVPIGXNNGVSQLPNGSVMGSFVTKTLKGKNLFTAKYWKLMNQKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXP7</accession>
    <name>A0A6P8HXP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integral membrane protein DGCR2/IDD-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557367.1">
        <property type="nucleotide sequence ID" value="XM_031701507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXP7"/>
    <dbReference type="GeneID" id="116294000"/>
    <dbReference type="KEGG" id="aten:116294000"/>
    <dbReference type="InParanoid" id="A0A6P8HXP7"/>
    <dbReference type="OrthoDB" id="5981403at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042378">
        <property type="entry name" value="IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2/IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2_IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028312388" evidence="3">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557367.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26492" checksum="446C341AB7F66347" modified="2020-12-02" version="1">MLVLFWLLTCLMTLCCGQGKIQDARFPAMKEPPLLMRRVHRAVRAVGSCRDINSNLISNGKYFVPSGKNPCLHCKCVSGQPQKCVATKCAVPTCPDYKAVDGQCCEYTCPEERTDGTQLAVIIGLSLGLLILVILLIVVIVRNVKKNRGYRATNQNLEEQGEQHRNNNIIATPLNNRLPAIREEQQERTFEPPPPYTPVRNVNKCKTQHQLPNPQVIPNEPPPPYEIQRNLRATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYJ0</accession>
    <name>A0A6P8HYJ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein bark beetle-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116294304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557730.1">
        <property type="nucleotide sequence ID" value="XM_031701870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYJ0"/>
    <dbReference type="GeneID" id="116294304"/>
    <dbReference type="KEGG" id="aten:116294304"/>
    <dbReference type="InParanoid" id="A0A6P8HYJ0"/>
    <dbReference type="OrthoDB" id="5977786at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027833301" evidence="10">
        <location>
            <begin position="20"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557730.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="67306" checksum="8F59BA4EB9D40AB0" modified="2020-12-02" version="1">MKLGQVLFVLFLLTQGTATFRSDAIAPSRNYTLLSNVLAGDLVGNITLKPSQGPFVIDKDLLVPEGSQLTLKPGAQLLFRPETGIQINGSLIAEGSPENKVSFSSFPYPNASSYASHYYGNGIRLVDGNNYTEGRLEILMNNRWGVICADRWTKENTDVACRHLGFLAGKRHFKQPFDRTKLYLIDYFACKGYENNLWNCDYRRKFMGCPQYPIGIECVGLMRFLKEKVKWRGMSFMMQNHRPLSILKHVTIKDAVFALNVTHQAPEISSVTIRNSIHGIQVSHLIEQSNIELTDILVHDNYLTGMKIMSLKSEVRIRNSSFTTTSLGDGFSFEDETVPIDFCTWGQNSTLVYPLMFSASSDGNDGYCSKPVWGFLLLITATRSVLLSNCTFLHNGKSGVNIENFAGHLQMTNSKMNQNALDGVNIKGLIGKLELNDLDVVNNGQLGLVLEKVSGKIVLESFNISHNKQDGVKVYQGTGFLMMKKGAIKENNAQGIYIGSLREVQLNLTSLKISMNKETGLTLEKTSNGLIMLTDVTTTLNSKYGAYFTQCSSPVAIERSSANANSGHGFYFQRQGGSVKISDFTASLNQESGLRVDDGISRLFIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYX9</accession>
    <name>A0A6P8HYX9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DnaJ homolog subfamily C member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116296598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560501.1">
        <property type="nucleotide sequence ID" value="XM_031704641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYX9"/>
    <dbReference type="FunCoup" id="A0A6P8HYX9">
        <property type="interactions" value="1627"/>
    </dbReference>
    <dbReference type="GeneID" id="116296598"/>
    <dbReference type="KEGG" id="aten:116296598"/>
    <dbReference type="InParanoid" id="A0A6P8HYX9"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000180">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="417"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031560501.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="55128" checksum="7597109D552DFA07" modified="2020-12-02" version="1">RKRLLNFEVRCWDQVDLELFDIVEEYKDNFYTLLGVEPTVKTSDIRKAYRRLSLQLHPDKNKEPDAEFKFRRLVAVAEVLKDEDKRKRYDAILRDGLPDWRQPVFYYRRVRKMGFIEFFILLFFILTIGHFIVIWSIYLEKKFEMEELISSKKKRDDKKKRKAKVDITDDDITELADILVHETGVSRPTFFDLLPFKIVRSSISFWSSLPARYRAYKAYLEEEKQRKLEEELELQEEAEEVEQPRPRRRQHVTLPEAAPDDDDSTWVGAPVTNMIEPEERDQDEDNLNTKSHEWTDEDFSRLSRAMVKFPGATPKRWVKIAQELGMTVEMVTKQLKKIRQHQGVSTGDTGKSVSQGAPGKLITSRKAATIAEDVATKAYPDNPVIQSTVQNVDQKSSAPANESSAEKPDKVSGTVMWTQNQQKLLEMALQQFPKTTPDRWTWIARNVPGMSKEDCIARYKTLVELMRQKKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I008</accession>
    <name>A0A6P8I008_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294743</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558255.1">
        <property type="nucleotide sequence ID" value="XM_031702395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I008"/>
    <dbReference type="GeneID" id="116294743"/>
    <dbReference type="KEGG" id="aten:116294743"/>
    <dbReference type="InParanoid" id="A0A6P8I008"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF17">
        <property type="entry name" value="PROTEIN CASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="426"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031558255.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="77385" checksum="CAB1115BA79D29FF" modified="2020-12-02" version="1">MAAASLQSMKNFWKEFNLPELQKTLDTTATELADRQDESETSRKKLVELSRDFKKNTPEELRKKVAPLLKSFQAEIDALSKRSKASEAAFLTIYKKLVDVPDPLPALEQAQIHQQKASKIQDYEIENKKLRETLDEYNTEFAEVKNQEVTINKLKEKIKEYEEKIEERVQSKVKEREKELQKEFAEKEKQLRETQVSVARKLGVAEHKTATLQAALDNTQTELFDVKTKYDEVTAARSSEIEILESDLDRAQQRALSAERELQSVKEDLLDRIQVLSQDTSDHKNTNVDAAIDAISRSTLEHELTAKERQISQLVSDVQHLQATITRLKDGNALEVNRLEEQISAKTSSLQALEQRLSHQEDYEEVKRELSVLKMIEFSTSLEEEEIKEATPKSLEIQFMDKNKRLQSENTNLKVENSELSARYQDLNRQYKETAHTVSEQKELITQLECDLLSVNALPTAYRGQGEGQASPPSETELVATAVQHTMSPTSDESTDKSAVDSLLPIVASQRKRFKLRNMELEAQTRHQQQQISVLQNEVDSLRSDNVKLYEKIKFLESYPTKGSSAKDDEAAFSRYSSQYEQRLDPFAAFSQREKQQRYMGLSPHEKVTLNMGRFLLGNKMARTISFFYLLLLHLLVFLVLYKMAHTESCKRDTASECAKRFAEHMLKAHNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0C9</accession>
    <name>A0A6P8I0C9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Deleted in malignant brain tumors 1 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116297883</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562059.1">
        <property type="nucleotide sequence ID" value="XM_031706199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297883"/>
    <dbReference type="KEGG" id="aten:116297883"/>
    <dbReference type="InParanoid" id="A0A6P8I0C9"/>
    <dbReference type="OrthoDB" id="5946501at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000005">
        <property type="entry name" value="Neurotrypsin isoform A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="17" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027985479" evidence="18">
        <location>
            <begin position="21"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="26"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="138"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="249"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="379"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="430"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="552"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="671"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="789"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="908"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="1053"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="21">
        <location>
            <begin position="1177"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="20">
        <location>
            <begin position="1304"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1123"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1247"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031562059.1"/>
        </source>
    </evidence>
    <sequence length="1544" mass="171770" checksum="32FF9745B25418E4" modified="2020-12-02" version="1">MRLTLKCILLIIATVSRIACQGKKFVRITGGSNELEGRVEIHFKGIWGSVCDDDWDINDGHVVCRMLGHVRAVRVSCCSKYGPSASGRVLLDDVNCTGNEDSLVKCRRRLAGTHDCDVYRESAGVVCQGKSSALRQNVRLAGGPDVHEGRVEVFHDGEWGAICDDNWDLKDGHVVCNMLGFGLAVSVSCCSQYSISDSKKIWLDDVKCKGHESSIMQCAKRAWGQHNCNNEEVAGVVCKEPKKTQGLIFRLAGGRFPHEGRVEVLHNGVWGAVCDDYWKLRNGHVICRHLGYKRALSVSCCSKYGSSLSTKLFLDDVNCEGGENSLLSCQHSFFGTHNCDSYKETAGVVCDKDTLNTEPPLISCPKGFQLTKDRSNCTDIDECRDNTHKCIHQCVNTIGGYKCTCPSSFQGNGQDCEKKNELSTSESKGVRLMDGQGPHEGRVEVWKDGVWGTICDDYWDPRDGHVVCRRLGYRRAKMVTCCSSFKGNHSLKMMLDDVGCNGDEDSLFSCSHSDWGVHDCDEKTEEAGVICTNAAEPTPMSPVDSISSRTKFRLAGGRTSNEGRVEIFYRNQWGAVCDDSWKLKNGHVICRQLGYERAVSVSCCSKYGPIKGGVFWMDDVRCRGNEKSLFDCRRREWGKNDCNKEETAGVVCYKEGITLPTGVSPTSAPTLRITGGPNRHEGRVEVFRDGEWGGVCHKGWELRDGDVFCRSLGYERASSVSCCSEYGPSASGQIWLTDVRCQGYETSFDDCPSRRREYYECTSYDLASVKCLFGTVTIAPTPGIPDIQVRLVGGYFSNEGAVKVLYGKEWGAVCDDNWGMKEGHVVCRMLGYKRARSVSCCSKYSAVRSGRIWLDDIDCQGTEDTLAKCTHGKWGQNNCNLNELAGVVCHTDNPPVRSSVVYPPPVKVRLSGGPYQHMGRVEVFYRGEWGAVCDDLWDLNHGHVVCRMLGYKRAFRVSCCSKYGPSVSKKIWLDDVRCTGNERTLMDCKRRQEGEHDCSNKETAGVVCEVEAQNKTSSKALGKFHIQEKIPSSASLTLPPTSPTTIGFQSRPVRIVGSSKFWEGRAEVRHDGKWGAICGTSWNLQAGHVFCRMLGLERAVSVSCCSKYGPHWTFNMLLDGVKCTGNERSILDCAHKRLGTHSCNVKTXAAGVVCYYGPRKVYTPIPRTTVQMGGKRIRLVGGKTPNEGRVEIFFRGEWGAICDDSWRLRNGHVACRMLGYPGAVKVSCCDSYPGKRASRIWMDDVQCKGTEKSLFSCRHRDWGQHNCNFNALAGVVCMLQPRSTLAPVYECGNKPDLPVRFGTSVNGQRKESSEPGHWPWQVMIMNRRGFQFCTGALIGYEWVLTAAHCFDRIRRPKDIIIRLGAFKVSPTSFLWVQNIPAIAVYRHPLYGSPVRYSNDIVLIKLFRQAKINRRVDLVCLTNDTKLFAQGTNCWTSGWGLLLNPTDRSPVLQQLSVSIKPRSYCRNYRRPTLHESMICAGNSEKGSDSCSGDSGGPLVCQNEGRWYLNGLSSYGGDCKQNGPYALYSNVPRLIKWAYSIMDRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3P0</accession>
    <name>A0A6P8I3P0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116298229</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562473.1">
        <property type="nucleotide sequence ID" value="XM_031706613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3P0"/>
    <dbReference type="GeneID" id="116298229"/>
    <dbReference type="KEGG" id="aten:116298229"/>
    <dbReference type="InParanoid" id="A0A6P8I3P0"/>
    <dbReference type="OrthoDB" id="5973041at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031562473.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45013" checksum="32BDF90BF3E170E4" modified="2020-12-02" version="1">MAVLLIKNVKTIGEFKAKLGEMRDQCKGRENYDKALDMIAGANGVQVAKFGHCPFFKYGCMFKTDPSGKPIVPELFTMDYIKEHCPAFQKGKFCPYNVAELKGLGKSCPAFKDGCPFKGVRNIGEFEGKLGEMRDLCKGKTNYDKALKIIQSVNGQQTAKLGHCPFFKFGCPLKNDREGKPIVPELYTMEYIEAHCPVFNKGKACPYNVPELKGLGKGCPEFKNGCPFKNVKNVGEFKAKMGEMRDHCKGKENYTKAMDLTYGAGGEAVAKYGHCPFFKSGCCLKSDLNGRFIIPGEITMDYVKGHCPAFEKGKRCPYNVPDLKGLGKGCPSFKDGCPFKNVKNVEEFKAKLGEMRDQCKSKKNYTKALECVYKANTEEAAKIGHCAFLYDHCELKTDNQGKPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4S3</accession>
    <name>A0A6P8I4S3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Galanin receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14 15 16" type="primary">LOC116296090</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559905.1">
        <property type="nucleotide sequence ID" value="XM_031704045.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559906.1">
        <property type="nucleotide sequence ID" value="XM_031704046.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559907.1">
        <property type="nucleotide sequence ID" value="XM_031704047.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559908.1">
        <property type="nucleotide sequence ID" value="XM_031704048.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559909.1">
        <property type="nucleotide sequence ID" value="XM_031704049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559912.1">
        <property type="nucleotide sequence ID" value="XM_031704052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296090"/>
    <dbReference type="KEGG" id="aten:116296090"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031559905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031559907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031559909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031559912.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="43611" checksum="FCB0B23EE4CDDE61" modified="2020-12-02" version="1">MNLSQNGSIVPKIPDYYKESLGLVITRLSFETAIALAGVVGNILVCIVIASKRLRGRASMHYYLLNLALADIGVLTVIFPIAVVRERIPGYWPFGRIVCLYIYPFVDTFYGASIWFITSIAFQRYRKIVVKGKGIHGESSSTRQIICNLLLIWLVSFLIASFPLFFIFTYFEDTXNNKIHCWPAWEKAPHKSLSATYTVSLIVFSYVLPLAVISWTYVGIWREIRMSNLFHQSLDREAGGSSNNKIHKRLNENARAKKILTPIVVTFAVTMLPVSVFRLLVVFWKPLPSIHHFWTFYNTMVIMTIANSAANPIIYSVVSREFRSAFIKLILRREHSILSRLPSKSDAHTKVTNDKRKRSFNVATPFSPKTWPDAKQLKETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I506</accession>
    <name>A0A6P8I506_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Krueppel-like factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116296029</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559850.1">
        <property type="nucleotide sequence ID" value="XM_031703990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I506"/>
    <dbReference type="GeneID" id="116296029"/>
    <dbReference type="KEGG" id="aten:116296029"/>
    <dbReference type="InParanoid" id="A0A6P8I506"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000563">
        <property type="entry name" value="Krueppel-like factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF49">
        <property type="entry name" value="WILMS TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031559850.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35856" checksum="9C972B5A368D02F4" modified="2020-12-02" version="1">MSTVVDPLLSTVTLDIFKPKDTIMDTEEHFRKLWFDVESFGSKWEPLPLEESSIFDSESSIDSDLEFSYGDNFLYSVDTMEEKYKDSSLFCDFPYGEIPLQLHISNGEILSAANDQSTGSVESKKNRPMADVEMTTIVQDSQVVEKSSESTQTDEEVINVTVPEPSVKAERSSKTTISKSKSPELNASNPTASAKSNILKANSTINTPNANSAKEVPGTSPNQSPKGKRALARTHKCTFEGCNKSYTKSSHLKAHQRTHTGEKPYQCNWKDCCWRFARSDELTRHYRKHTGVKPFKCPTCDRSFSRSDHLSLHMKRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6F9</accession>
    <name>A0A6P8I6F9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acidic repeat-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560612.1">
        <property type="nucleotide sequence ID" value="XM_031704752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6F9"/>
    <dbReference type="GeneID" id="116296694"/>
    <dbReference type="KEGG" id="aten:116296694"/>
    <dbReference type="InParanoid" id="A0A6P8I6F9"/>
    <dbReference type="OrthoDB" id="8943025at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560612.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="38929" checksum="6A15C2EF21391C39" modified="2020-12-02" version="1">FKHFLYCSQGWTTTIILKCNQTRKGVDDGNFSIIEDTSNPVFQLEHKCCCPDACSDGDPTATTAPVSHKKPYDIVGEVLGGFVGFVLIVVGIAFYCRRRNRRDEHNRPLIIDRPSYRAVENRDPGIEAPDPDDDASDNDDDASDNDDDASDNDVDASDNDVDASDNDVDASDNDVYVSDNDVDASDNEVEAPNADDEAPNLDDEAPDLDSEASDIGSEAPDLGGEAPDLGGEAPDIGGEAPVPDIGAPDPDDRTPDPEDEAREPGSVASDPDVGVPVPEVGAPDHDGEASVPEDHVSVSIHADSNMRGESPHIADVIPRISDEDLSYPIAVQSNPEDQCCEEEPSEPAVQSQRQPVEHSLESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6Q6</accession>
    <name>A0A6P8I6Q6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein crossbronx homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563021.1">
        <property type="nucleotide sequence ID" value="XM_031707161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6Q6"/>
    <dbReference type="GeneID" id="116298638"/>
    <dbReference type="KEGG" id="aten:116298638"/>
    <dbReference type="InParanoid" id="A0A6P8I6Q6"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="132"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563021.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37278" checksum="5462284905394652" modified="2020-12-02" version="1">MPSESPIYSPKVNNDLEALSISCFKDAKKTMNSESPTKSAVTIVSSLSSSQNSDTTTTTTTDISSSSPNKSNSSSESPTFRERLRSARKLIPQYPGRARLIFSTGDTDEISKDESKVKSKTTQRTDGFRSFFREHYIFSEYKSLCTNHQSGVYVMPSLKSLQVWHGIIFLRAGPYRDGIFRFFVFLPDDFPDSRPLLKFTTPVFHPQIHPNGVLNLDIAFPTWRKEKHSVWQIIKFMKNCFYNADTWGATNQAAINVMHNSLEEFMKKAEHCSLQSQLLYDKELESESSVEDGNFLKAKKMTQDEFEERKKRMMQGKSFGSRSCASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6V3</accession>
    <name>A0A6P8I6V3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116296806</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560762.1">
        <property type="nucleotide sequence ID" value="XM_031704902.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I6V3">
        <property type="interactions" value="1259"/>
    </dbReference>
    <dbReference type="GeneID" id="116296806"/>
    <dbReference type="KEGG" id="aten:116296806"/>
    <dbReference type="InParanoid" id="A0A6P8I6V3"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031560762.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19140" checksum="F1E3159279DA210A" modified="2020-12-02" version="1">MASFLSRSVRPTFSAFIRPFVARSAAYTTEKGQMVAGQGETSVDTAVDSEQSGRIAVLSGIPEWHLKNRKXRIFFPAKNAMQSGTQSFRTWRLEFENMERWENPLMGWASTGDPLSNVTVDFQSKEDAIAFAESQGFNYEVDDRHEKKVLPKSYGANFSWNKKTRVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I813</accession>
    <name>A0A6P8I813_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116297177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561207.1">
        <property type="nucleotide sequence ID" value="XM_031705347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I813"/>
    <dbReference type="GeneID" id="116297177"/>
    <dbReference type="KEGG" id="aten:116297177"/>
    <dbReference type="InParanoid" id="A0A6P8I813"/>
    <dbReference type="OrthoDB" id="5985939at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031561207.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12512" checksum="1E57DC7759DDD6D0" modified="2020-12-02" version="1">DGNFSEWSNWTRCSVSCGNGMQKRNRSCSKPTPAYGGNNCTGNHTEIRYCTQLDCPVDGNFSEWSNWTRCSVSCGNGTQERNRSCSKPTPAYGGNNCTGNHSEIRYCTQPHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA18</accession>
    <name>A0A6P8IA18_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras GTPase-activating-like protein IQGAP1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297454</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561535.1">
        <property type="nucleotide sequence ID" value="XM_031705675.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IA18">
        <property type="interactions" value="1629"/>
    </dbReference>
    <dbReference type="GeneID" id="116297454"/>
    <dbReference type="KEGG" id="aten:116297454"/>
    <dbReference type="InParanoid" id="A0A6P8IA18"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000013">
        <property type="entry name" value="IQ motif containing GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000004">
        <property type="entry name" value="IQ motif containing GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1456"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1541"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1466"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031561535.1"/>
        </source>
    </evidence>
    <sequence length="1705" mass="194851" checksum="A85B88C95A270980" modified="2020-12-02" version="1">MENNIDKEDGHWEPSGIYESGGESGLERASGTEMDEQRKQNLAYQYLCHLEEAKVWMEACLKEDLPETTELEESMRNGVHLAKLGNFFAPKVVPHRRIFDKELKHFLSKGLHFRHTDNINYFFKALDDVGLPKVFFPETTDIYDKKNMPKLIYCIHALSLFLFKLGLAPQIQDLYGKAEFTEEQISAMRKELEKYGLQLPAFSKIGGILESELPVDEAALHAAVIAINEAIDHQDATGTMEAMKNPNAHLVDLDSENTEEYQNLLYEAKSTKTKQALAKSPGSDKEEDIYDKYLTQAEIQGNINQVNETIRKRKAEEALKKSINNINSMLDGEDLEALIAALSDKSAGLRNVDGQNGPWYLMMLREKRQVKQETTGDPNAQLTQSEIQESINGANEAAETHRQMQATVSAINKSLDGENAEETHMLIQKQEAMLPKVLGRSAYLYHYELKKAKNQKQADLEHIEIEDRIKVLTAAAAINAAIDKQNADELMKTMEDPNSELSSVDETLGRRYLDHFMSVKHEKAQDCGIGKDDLTPLELQICVDYVNAVVQEEHDLIAALSVINVNIDKGDADETTRSLQAAAAKLSGVDAANAEIYQDVLFATKRSKAQKTNDRSAELWHDEIQPCIDHSNKHADETHQLAQGLVAINQAIDRGDQQSFSNALGDSAVGIRGVTQECTEKYLHALQEAKQKKKENGGTSPWLEQRTSYGHVYYYNNENGQTSWTKPDDFKDNSSLLTKEEIQTVVSRETGEHDRMVYLTSNEPTIIKLQAHWKGYLARKSYKNRVTFIKEQLPAIIKIQANIKGFLQRTKYRKRLKELKSSEQDVIKIQSHVRMFLARKHYRGRKKYFDEHQAAIIKIQAWVRANVAQNDYRKLISMQDPPVKTVRKFIHLLQHSDADFEEELELQKLRAQVVTDIRSNQQLENDLNLMDIKIGLLVKNRITLQDVVHHGKKLKREKQDMMSAVQRTKGIKSLSKESREKLEAYQNLFYLLQTNPTYLAKLIFEMPQSKTTKFMESVVLTLYNYASNTREEYLLLRLFETALRQEICSKVDQPVEIITGNPTVIRMVVHFNRGQRGQSSLRDLLQPLVNDILKDKNINVNTSPQDVYKSWINQMETETGQTSKLPYDVDPEQALKHPEVVERIGASVKTLIAATDKFLNSIIQSVDKIPFGLRYVAMTLRVSLMEKFPNVPEDEILKVVGNLIYYRYMNPAIVAPDAFDIVNLSVEKGLLPEQRRNLGIIAKLLQFAASNKLVTMNSNKEEWKASSDNDLNDSAAQTNDAFNVYDGANSHLGELNNYIKEAHIKFKKYFLEVSTVEEPESRFNIDEYTDVVMLTKPVIYISVQEICDTHTLLLEHQEQIAPDVNDPLHELLDDLGDAPNVKDLIGGNPDDEDEDQELANVAKTEISLMLTNKFEVPDDDDSDMRALFVRTKRLIVDVLMVQQGENLTEILETPATEEQETAHTNLVKEREKNEERKRKNTQVRRSASIYGDNKLPLEGLKRKIIRNLRMLESQGLVTIKNDYQDIVNAIAKDIRNQRRYRQRRRQERKKLKQTLESLQTKTHFYEEQIDYYNQYIRVCLDNLSKMGKKPSRGIKQGKKAKEEVYKGELKYSAQRLYEKGVILEIEGLPPAQFKNVMFEIKSGDDVGSFAVSAKFMGVAMEKVELVFQDLLQLQYEGVAVMKMFGRAKINVNLLIFLLNKKFYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA34</accession>
    <name>A0A6P8IA34_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300253</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564943.1">
        <property type="nucleotide sequence ID" value="XM_031709083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300253"/>
    <dbReference type="KEGG" id="aten:116300253"/>
    <dbReference type="InParanoid" id="A0A6P8IA34"/>
    <dbReference type="OrthoDB" id="70142at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564943.1"/>
        </source>
    </evidence>
    <sequence length="1129" mass="128209" checksum="8504D28D89DC6381" modified="2020-12-02" version="1">MEYTELVKMTASMRGQYQRLWLDSGYYETLLPNSPWHKIKESVNSLLAQEVKQLTSHTELTSSILKLLGQPFIDEYLLNEPSYAANSIPKPAADEKDIQREANDWLKDKLQKIIKELRLKNPDYPDDEDEGLSQDCLEYIGFGQQVMYQGMERDLSAAEKNRDVNDQCFADNSLISGHQSEALGASVSCILRNHPSCLKRVSLQLKGRQLPNTLRQLIWRINMFKADTSMNNYDSHINELRNQFMTAVKWGAKELEIDHPTCSSIDGIIRHAVTEIYSLIPCIQDGNMRRICFTMATQALNILYVHGRSYEPHYALLLLPLVWTYSGYASKQDFYSQNLAECLYFLLKNCFPSRVDIFTIADHVIGRLQQGDPQLFDHLTTSMQRNIAFDPREFLVNFMHKERKRAIEMEQSLSQDNMYSSENEENLDDAKSLLSHPIIFIRKWVGEGFVGVLDLPAILFVWDQCFLSNWQPAILENVCLVLLQLLRPKLMLATDYHGIKTVLLSHPHSLYTCDIQRGVVYLSNGGALQDVGSLRQPSQAEIEMSSLQSTPHNNQTPRVKSTKSTRSKSRSTTLTTNNQPDLGELWIEKRVSDTPSARISNAESFDLYIDEVRFIPDNATVVKVTGRILSPFWKKPRSLDVSDIDAYAKLDSPARCPQFHYRYSVSAPRSGIPVDSVVLLRVYTVDVDTAELVVIGNCAVNLYKQEYDKHFLNVGGKQLRLKHQLPSSVSRLDESLFIDPVCLPVVTLLVRILPHSEDFVEAPGYSSGYYDSSAFRPDGSEKRIYNHYRVFDPYPPTVREAIRDVKEEEDQINIEGDISNQEMEKWYRKRMRKEQLDRKPARSLELMQLVQYDQNQGLCFSVDQAFGLPTASFVNVLTFVSEXPTARIKGKTTEGFGGEESSLTNKRDFESLQKSPKWVDDLKTIHPHLDPLSSLIIQLYSLDASYEPRADRQGPGSVLEKKGKMLSLVSQGWXVLQLFNKKYVNGGLHHLPLFEGQPSSTFMEFLSSHPGDVSLHQAVLQGVHQLQGTSSIMVRICDGHYLQDSCIPLPVKESLLSIGNQSKIKKTSQGKSGKPIADLVLQSLTKQERKGGMNGQPFVREKDHFQEAMNIVFTNLMENVLLGLGLGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBM5</accession>
    <name>A0A6P8IBM5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">LOC116300104</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22 23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564735.1">
        <property type="nucleotide sequence ID" value="XM_031708875.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564736.1">
        <property type="nucleotide sequence ID" value="XM_031708876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBM5"/>
    <dbReference type="GeneID" id="116300104"/>
    <dbReference type="KEGG" id="aten:116300104"/>
    <dbReference type="OrthoDB" id="6019542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031564735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031564736.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="56263" checksum="8B7E68738A9D6671" modified="2020-12-02" version="1">MTSGSSKQQNAGPPNTMTTTNLTSKSVPQSDSQATVPTTQLMSLKRVLGIPGASSMVAGIMIGSGIFISARWVLVYSGSVGLAFFVWLLCAVVSFIGGLCWVELGLTFPKCGGEYILIKHTLGSVPAFALIWLKTLITTPCSKAIGQLTFAHYVLGPFFPGCTDREDLVPLLKIIAVWSICTLCLLNCLSANWATRVQIVFTAGKFLALMLLIGTGFYSLAQGHTSSFKDSFKDTTTQIGMVGLAFQSGLWAYEGWDSLNDVTEEVNNPKRNMPWSVLGSVVLVTCCYFLVNVGYLAVLTPQELKESPATAVSVVQRVYGFQVAWIVPALVACSIFGSANGSSFSSARVMLSAAREGHLPAVLAMIHTNKRTPIPALLLSTITACLFLIPKTSTVQSLMKVFSAAAWLTHTLTVIGLLWTRYKKPDLPRPFKLPIFIPVLFLFISLYLTITPFVDAPVETSIPLVFIFLGIPMYHFFIYFKATPRCIVICFEWISFKTQQILNVNYPSISMEINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDE1</accession>
    <name>A0A6P8IDE1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC116299634</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116299634</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564181.1">
        <property type="nucleotide sequence ID" value="XM_031708321.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564182.1">
        <property type="nucleotide sequence ID" value="XM_031708322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDE1"/>
    <dbReference type="GeneID" id="116299634"/>
    <dbReference type="KEGG" id="aten:116299634"/>
    <dbReference type="OrthoDB" id="5977436at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="103"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564182.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51824" checksum="9F055B9F67084908" modified="2020-12-02" version="1">MSKPLRLANEAKCACTNDNPLRFRRFHDRERDELLGLQCLICDKEYLKKTFVLISRDGHILQSGRHKFYLAERSHIPEDGVHMVHSAKTAIENGDNLKPGDHIAWKRPLGHWHHAIVTETNDSGNEVRVVHWHGDKSGIITPDCKIQEEWIDLKKQKGSLYLMDYSEEILNTNPARLVIARARSRIGDKGYHLVTDNCETFASFCKFGVAISQQIIWACKELKNECKKSGLKTFAKVGLAELTEQAVYQEQWLGFSLVVVLEGIHTCIDIKDLWKARREGKMTKKIVIEQITERLTQAVFCGGLAGVGSVVPKVGFIVGFFGGIVGKWIGSMVGPSVGQFIASLVEYDDRAICKITNLRSGDHLVLPYDSEESHHCIAQWYNEETNHINVIHNTEKYGVIQEWIEFVQPTYKVIYEEKEGCTPDEAWSKAVSNLGRKQYDAECFNSKHFAQMCCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDZ8</accession>
    <name>A0A6P8IDZ8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="13">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299375</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031563885.1">
        <property type="nucleotide sequence ID" value="XM_031708025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDZ8"/>
    <dbReference type="FunCoup" id="A0A6P8IDZ8">
        <property type="interactions" value="1964"/>
    </dbReference>
    <dbReference type="GeneID" id="116299375"/>
    <dbReference type="KEGG" id="aten:116299375"/>
    <dbReference type="InParanoid" id="A0A6P8IDZ8"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563885.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34379" checksum="2AB5607487A35D4C" modified="2020-12-02" version="1">MKLANMELSMKPVVLAAGLTLVIAVVGLAAYFTLGKKKKLIALDSQKKIPFELIAKEIVSHDTRRFKFALQSPDHILGLPVGNHVYISAKIDGNLVIRPYTPVTSDDNKGYFELVIKIYYKDVHPKFPEGGKMSQYLESLKLGDTVDIRGPAGKLVYKGRGTIAIKESQRKPEIIRKAKHLGLISGGTGITPMLQIIAAIVKDQGDTTQVSLLFANQTERDILVREELEALEKEEGPNGRFKLWYTLDRPSEGWAYSSGFVNADMIKEHLPPPGPDTQILMCGPPPMINYACIPNLEKLGYTTDMYYAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE93</accession>
    <name>A0A6P8IE93_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116300312</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565012.1">
        <property type="nucleotide sequence ID" value="XM_031709152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IE93"/>
    <dbReference type="GeneID" id="116300312"/>
    <dbReference type="KEGG" id="aten:116300312"/>
    <dbReference type="InParanoid" id="A0A6P8IE93"/>
    <dbReference type="OrthoDB" id="10251692at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="894"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="927"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="960"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="834"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565012.1"/>
        </source>
    </evidence>
    <sequence length="1073" mass="122467" checksum="4C10CBA4CE87EA2E" modified="2020-12-02" version="1">FGFFPLWIKINYNFHEFSKRRAEIFNTLKKVFAIPQTDDSPAREYMVYMGISLGKRDVLICVLVPQCVRQNIRTSLQYEDTSIQLRRAHVTGIYFSRIKNKNYISWSQKNKLTGSDLSISSAMSSDFGELCDPAYEDMNNNDIATRNVVHHSYQDYQPRGLAKDENFNDIQNEILHTKRERYEASIPHNDSENKDFRYQGNESVSSVRPYGGSDQSANIDSRCQDNRIVSSLRPFEEDSSNMNSRSEGSHSVSSVRPYNEDDSSNMNSRSQGNYSVSSVRTYREGVNTNTGPKLVRANYGYISASPKLDSTSAASEESEKLSYGAFFFVDKNSSPKKVYSKNREARSVESNDSDQFEPPDASSPFPTNDGPGSNSGHYGDAIYPAREYNLARETPKSYEEGIKYSQRSEIDVLRPNSDLDNGAPRESLTRESPRSDQEDILFSRKTEFSFEKPTLFDSDHERELLYWSRNVSQNEQETDEHPSLWYQPRLTTEISYDRNPQNQLEHAYGRSPLSSSDAQRDVQERKPNLLKKHLQGNDLRPVGYWQGDEQGSSSHGDDVGYHRNEQVQSNFTSYRIPDKLEDRRGLSYQGYSVGRYSDGECPSNHTGYHDDHNQRLSYYEDSFHYYGNEQVASNHADMSFSNHRCDEDQRPSYYGNDWTSHESYMEAEPEPEPSPVTSRLSLEERNGQAAVRQSTPSSSSSGFFTADQSVVLRSDKISRSMPSLHAKQHDDMLSTPQPRWSDSRRSNNGNHSDYRTNMSKYESEAVLEDNVFVDIHKNSVRFKAAPQYCSPPDYQEAMIRKSYLSLSSVSLDSKRMKAKSPLLSSQSVTSIYKEKEALLSREELQESIRSAEEKQWEILLKKSKEFLIAAKMGAEEEVRNLLEEDVDVDYKNEFGHTALMVASREGHLEVIHVLIDHGANMNIQDKYGKSALHEAAWSGKHQVINALLSNEAEMNCVDEEGRTPLQYASLRGKTKVVEVLLQFGAEDSILNKDGESAVEIAYRCRHKDIVKLLLKSTDKKTRKNMKAKIRKQRIQRLTTATSLPNLTKATSLKTLRRSRSKPDVNKKGTCVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEI4</accession>
    <name>A0A6P8IEI4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116299707</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116299707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564285.1">
        <property type="nucleotide sequence ID" value="XM_031708425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEI4"/>
    <dbReference type="GeneID" id="116299707"/>
    <dbReference type="KEGG" id="aten:116299707"/>
    <dbReference type="InParanoid" id="A0A6P8IEI4"/>
    <dbReference type="OrthoDB" id="5958267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031564285.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34745" checksum="C4BFCDADA51070F9" modified="2020-12-02" version="1">MKDVRCELLDEDKASKAADFVDETGYVYYDLQQTLYKGNSFTVRSSDVCYNGCCRTQPCLNGGTSVEHCEKPKVKFSCKYPATYKGNICEKREFSSCIDVFNGTAPGTIPANGTYIITRSDTKTTVPVYCAFESPNQAWTVIESFSLQNKDYFKNQGLHQDYPKNQESFSWNHYRLSLGNMKYFQSRSSLFRATCDYDKRSSLTPDFLLGLLRVMDITSSEPFNNKCKKYLHININGDECFNCTTKSYKPANEHFHIDPSGCQFNPTSDFPVADYFGFYLAIDPVFKCTATQQSTTQWWLGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEN9</accession>
    <name>A0A6P8IEN9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radial spoke head 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564485.1">
        <property type="nucleotide sequence ID" value="XM_031708625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEN9"/>
    <dbReference type="GeneID" id="116299908"/>
    <dbReference type="KEGG" id="aten:116299908"/>
    <dbReference type="InParanoid" id="A0A6P8IEN9"/>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564485.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25004" checksum="A0029E88D4B78EEF" modified="2020-12-02" version="1">MSDLHFDSDEEGDREYDLGEYEGQRNELGERHGVGKAVLPNGDIYKGSYHNGKRNGQGSYFFRRGAKYTGTYDNNKKQGRGTFVYPDGSKYEGMWVDDERNGQGLYTYPNNDVYDGEWKKNKKHGRGSYLCAKTKVKLEGTWVRGKLNGTGKMILADHVYQGKFADNLPSGPGKYVFKKGFEQYGVYNIKEKKKRQFDEEEEPIRTPIWKCIGLSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEW7</accession>
    <name>A0A6P8IEW7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116300199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564875.1">
        <property type="nucleotide sequence ID" value="XM_031709015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEW7"/>
    <dbReference type="FunCoup" id="A0A6P8IEW7">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="GeneID" id="116300199"/>
    <dbReference type="KEGG" id="aten:116300199"/>
    <dbReference type="InParanoid" id="A0A6P8IEW7"/>
    <dbReference type="OrthoDB" id="365445at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031564875.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21113" checksum="E79DFEDC898C6AD7" modified="2020-12-02" version="1">MEESHLLVLGPEGAGKTLMLKRLQTISSQMSLPQAQRRHDLGEAPPTIPTVGVNLVTINLYRKKYTFRELGGAMGPIWSKYFKDANLLVFIIDTANRTKISSSCIQLLDVLSSKQTINMPVALIFNKVDSPSCMPMAELLTILRLNDIILCAKHDITIIESSFRTGQGIDEIMKWLKLKAGPKKRGSFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF85</accession>
    <name>A0A6P8IF85_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116300620</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565383.1">
        <property type="nucleotide sequence ID" value="XM_031709523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IF85"/>
    <dbReference type="GeneID" id="116300620"/>
    <dbReference type="KEGG" id="aten:116300620"/>
    <dbReference type="InParanoid" id="A0A6P8IF85"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565383.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="23514" checksum="4CB9F2462DDC3797" modified="2020-12-02" version="1">MQDFQKISKSHLKVNCCRPEDLPSSLQEKEETNKESKRMMEIEEEEAKMKLKWSIIQERAVMRGIQTIFKKYKTNMKKGEEKEWDKLKSRIKAEQGRKKKEFQENVRRQTTQQLELLKSLGYRVVETGDEYCFFVPTCSGCHKASSQLLVCEACMVTWYCDEWCQRKDWDERHCYQCRTKRMNKTSCTFPFKVCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG52</accession>
    <name>A0A6P8IG52_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116300888</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116300888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031565714.1">
        <property type="nucleotide sequence ID" value="XM_031709854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300888"/>
    <dbReference type="KEGG" id="aten:116300888"/>
    <dbReference type="InParanoid" id="A0A6P8IG52"/>
    <dbReference type="OrthoDB" id="6277246at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001500">
        <property type="entry name" value="Zinc finger protein 292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000257">
        <property type="entry name" value="ZXD family zinc finger C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="547"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="607"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="668"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="698"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="728"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="758"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="788"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="818"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031565714.1"/>
        </source>
    </evidence>
    <sequence length="1195" mass="132185" checksum="953F8FCEA27EF991" modified="2020-12-02" version="1">MESQGQPCLKGLPSTELGAQSSNNQHGQNNTVEHQQKRNNKHRLSIDEHLSPQSKKQRDDNDKECFPTAYVDSSKTCEEKSDIPEMDKMPENGPDDSSIPVSHYTGXASESPGRQVNGNLQDVSSSMYYESEDIRKQDAGSQRSKTKDLISEEKASNTCLIDKRGFHGNIPEEKTCDVEGAVSTDVNELSQSDIKPCNIQVSNASNHSEEIPGPISSLSSSDDQESHVYIISSPIDQHIPAEFHSQPNPDENLKIHVDYDYGDISASPKAIESYNSREQQQSEPDQSKRIPMKLDLEHLQLMNVGTGGVEYMEGLQSIVSVKSPNPNDTSKSELHTSSQETLIVRNNEQNTSSIQDSIPIQVYPQPKGISLVTSSGILTADISTFSTQVPAILTEGDADDTEAAVSFAEQFHVVTTSSAFTXTSQIQGQTTTNEMLSVMMPSGDFTKGVILTPDQQQAFLGDMITSGVGQGQTLHITIPQVATMTRPLINTTAAETTGESSRTDVQVSSSAENKAIKLRIISNNQDKMNKEINEGRGGEVVEGDRVHLCPHPSCNKVCQRAHRLKLHMLTHTGERPYKCSHEGCEWAFTTAYKLKRHERGHTGERPFVCPHEECSRRFTTAYNLKTHIRTHTRPNTIMCDHEGCDKTFPTLHKFRVHERKHQQEEKPFKCEIDGCGKEFSAMGPLTSHLKSHSGEKPHGCPMEGCCKRFTKASKLKLHLRTHTGERPFRCDFEGCGWSFTSAYKLKRHMRKHTGERPFVCIYEGCHKSFTRSSHLKTHTLVHTGEKPYVCPIDGCNKAFTAGSSLNVHMRKHTGEKPFKCEEDGCSKAYTTASNLRTHQKRHEKSAKFPEGSSEDHPMPADFVTVSTMSSVSSAGSLVDNDNEVXYTGIHTFSSEDFTTDDVTSLPVSVHFPAGSLSAIVSNRGNPLSFXTACSSSNEHTDVNDEEDQGLQNDMNSKGITTVTLPVSVDASHIDVAEFVVRNNNSEPALHGQEVSKHSDVENLKHDGGFDLSITSMVSHLRSHETSPNRKLVSTEVLTEQSPTCERLVIDNKYVPSHSRSLEFRTPMNPEDQFKPPAVIFQDDCSKSGSSDTESESSHPNPGLMQITLPQEVIQVHFPSTSDSPLPPDNDNPIDVDANTSHHLQSYEGTTLSSLQDPSIGKPQLSPYMEEQSSPEPDDNNIDNYPESTINLQDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGA4</accession>
    <name>A0A6P8IGA4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rab-8A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116300906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565736.1">
        <property type="nucleotide sequence ID" value="XM_031709876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGA4"/>
    <dbReference type="FunCoup" id="A0A6P8IGA4">
        <property type="interactions" value="2290"/>
    </dbReference>
    <dbReference type="GeneID" id="116300906"/>
    <dbReference type="KEGG" id="aten:116300906"/>
    <dbReference type="InParanoid" id="A0A6P8IGA4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031565736.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23860" checksum="B96F50232FE952B6" modified="2020-12-02" version="1">MAKTYDFLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNDKSFENIKNWIRNIEEHASQDVEKMVLGNKCDMDDRRQVSKERGEQLAVEYGIKFMETSAKSSINVEEAFFTLARDIKVKMDKKLEQSSPQSTGAVKVTQHREQKRNFFRSCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHQ3</accession>
    <name>A0A6P8IHQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Neuronal acetylcholine receptor subunit alpha-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116301425</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566341.1">
        <property type="nucleotide sequence ID" value="XM_031710481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHQ3"/>
    <dbReference type="FunCoup" id="A0A6P8IHQ3">
        <property type="interactions" value="739"/>
    </dbReference>
    <dbReference type="GeneID" id="116301425"/>
    <dbReference type="KEGG" id="aten:116301425"/>
    <dbReference type="InParanoid" id="A0A6P8IHQ3"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028519791" evidence="14">
        <location>
            <begin position="23"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="245"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031566341.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56041" checksum="62D5DC38B4D94766" modified="2020-12-02" version="1">MRDKNLLTLVLLAVISTIAAHGAHENDIEHKLLADLFTKYNKDARPVINKTEAVEVQFDLAYAQLINLNSKDQILQSKVWLRQMWTNPFLTWDPAKYAGIKSINVDPKLIWKPDIILYNNIGFGETGAVDGFDTKATIRYNGYTEWFAPTEIHSICKIDITFFPFDEQFCTLKFGSWTYTESQLNFTKKRATADMSMYTISGEWDLVNTPAVRHAVKYSCCPDRFLDITYTIHIRRKVLFYLTNLIVPCLVLAMLTVFSFHLPPESGERMGLVITILLGLTVFMLVFTENVPRTSEVTPLIGKYAFTVLCIVAMALLITCCILRVYHKDPDRKIPRVFRKLIFDLLGPMLLMKPPVEESFALEAEKGRTMLNLTKAKGTPYDLHHISNYSSPLELDKLAVRLEPPQTSLPNGKVFHSSVVSNMSQDASEEKLDEIANYVHTIVDHIKEMKTTEGKVGEWRYAAAVLDCFFFWVILIIILGSTLAFYFMIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJN7</accession>
    <name>A0A6P8IJN7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fizzy-related protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cdh1/Hct1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566663.1">
        <property type="nucleotide sequence ID" value="XM_031710803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJN7"/>
    <dbReference type="FunCoup" id="A0A6P8IJN7">
        <property type="interactions" value="2435"/>
    </dbReference>
    <dbReference type="GeneID" id="116301705"/>
    <dbReference type="KEGG" id="aten:116301705"/>
    <dbReference type="InParanoid" id="A0A6P8IJN7"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="11">
        <location>
            <begin position="175"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="434"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566663.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="53754" checksum="CCDD690429D34742" modified="2020-12-02" version="1">MDPEYERRLLRSPGVSPLASPLAVRRINSSPGISPAKDRYGDRFIPSRAGSLWKGNINFVQENSDPSSKSLSSITKEAGGDIKEGIAYQCLLKNELLGAGIEDLKDCQTEDRKVLSSNSNYVHNVFQYQVRRSQKEEAQSSSAYSLSPVGKKSQRLLRSPRKSTRKISKIPFKVLDAPDLVDDFYLNLVDWSSQNILSVGLGTCVYLWSACTSQVTKLCDLSSDGDSVTSVSWSERSGLVAVGTYKGLVQIWDASAQKRVSTMEGHSARVGALAWNGDFLSSGSRDRLILQRDVRSPSTIEGRLVGHRQEVCGLKWSPDRQHLASGGNDNKLLVWNLSGVAPVQQYSEHTAAVKAISWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCVDTGSQVCNLAWSKHSNELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAVSPDGEAIVTGAGDETLRFWNVFSKARSQKESKSELNLFSRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK14</accession>
    <name>A0A6P8IK14_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116302176</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567261.1">
        <property type="nucleotide sequence ID" value="XM_031711401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IK14"/>
    <dbReference type="FunCoup" id="A0A6P8IK14">
        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="GeneID" id="116302176"/>
    <dbReference type="KEGG" id="aten:116302176"/>
    <dbReference type="InParanoid" id="A0A6P8IK14"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000007">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF431">
        <property type="entry name" value="TETRASPANIN 26A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031567261.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29825" checksum="0D0BBDAC44F6CCF6" modified="2020-12-02" version="1">MPRERSEVSLCVKYLLFFFNVFFWLIGGLMISIGLYARFEKTAYQEFFSDVLTDPAFALIIVGAIMFILGFSGCIGALRENICLLKFFSIFLAIIFFLQLSLGVAAFVFQDKVEEVIVDKLQVAIKKYRDNYDLQNLIDGVQQEFKCCGGKDVDDWDQNIYFNCSSPGSESCGVPFSCCKEDIINRQCGYKIRLEKSTSKRGQVIYTTVCVEAVKTWFKENMIIIGGAAVGVALLQIMGICFANSLMSDIKMQKAKWNRDYPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKE6</accession>
    <name>A0A6P8IKE6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116302179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567264.1">
        <property type="nucleotide sequence ID" value="XM_031711404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKE6"/>
    <dbReference type="GeneID" id="116302179"/>
    <dbReference type="KEGG" id="aten:116302179"/>
    <dbReference type="InParanoid" id="A0A6P8IKE6"/>
    <dbReference type="OrthoDB" id="5915502at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38640">
        <property type="entry name" value="GEO09659P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38640:SF1">
        <property type="entry name" value="GEO09659P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567264.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17887" checksum="4B671BAE10AA0B42" modified="2020-12-02" version="1">MASITIEDVRRSLIKYTPYFGGLSYSALAFNSMGIHFPFLDKTGQLIMFNSTLCLSHIGFGVYIYNRPINDVLKPSRSRRVVWSIFGSWIMNLGSVLCWAIVKEIGPKNKLARALIGLTGGCVFLYIATDYLCAIDKLRAQDFPDDDRDSGNEDDEDDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL27</accession>
    <name>A0A6P8IL27_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116302077</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116302077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567133.1">
        <property type="nucleotide sequence ID" value="XM_031711273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IL27"/>
    <dbReference type="GeneID" id="116302077"/>
    <dbReference type="KEGG" id="aten:116302077"/>
    <dbReference type="InParanoid" id="A0A6P8IL27"/>
    <dbReference type="OrthoDB" id="5976775at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031567133.1"/>
        </source>
    </evidence>
    <sequence length="658" mass="75292" checksum="3D31FB015518D40A" modified="2020-12-02" version="1">MWVTLINNRNNEMAEYISNSDTCMDKVIPQIVQQNFEQYKTSIDNKVRSLEILYTGGMISKRKYTNIRNTYTGPVFKDCEMPKILSYKALISFINTSIEIGDLYSLQEFGKSVNMPASPGVYRQLEPFILRLAYLYLSIHAKSPILHWFNGKEYEFLVTVGADAAPFGRDECATAYLVSFLNLLKKVNSCDDNHLLMGASCSEDDGLLIVYTKQLFKEMEDVERKVYDIEANGTKHACKFILKLIPSDMKWMATMCGELNNAATYFSSFANVNKGNMDTRNSRIGTDPKTSTWQPWTYKGRLDVANKVTKEKSKLTASELKGRTKVTQFIAKSKSRQEFVPPLGKYVDCCKAEPLHNCNNAWQQWFCILLTLAISFVPEGSLKSCSTVNELPSQSAFVKFMTSLKEVVKCTRLWKNICKWFSEGRKKNQALSYRFTGKESKLCSWGFQELIKVLLAFVSDNKTKLKLHVLSFIALKLRDSASIFSQFETNDADVGRLTSLCSEFFNAWSIFLGRITPTVWTIAYAVPFHPQQLVRELGNGLGLNSMQGREAKHIKLKKYMEFTPSTSKHSRWLSVFKHEFVNAVWLKEKKPESWLKINQPRDHFIPKCVENTSFCYCGLKKIDSPDQLKCEICNSQLMHLIETSAKEGKLHNDLKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM92</accession>
    <name>A0A6P8IM92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116302701</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116302701</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567916.1">
        <property type="nucleotide sequence ID" value="XM_031712056.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031567917.1">
        <property type="nucleotide sequence ID" value="XM_031712057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM92"/>
    <dbReference type="GeneID" id="116302701"/>
    <dbReference type="KEGG" id="aten:116302701"/>
    <dbReference type="OrthoDB" id="10666855at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567917.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29305" checksum="D9A473E402777119" modified="2020-12-02" version="1">MRPVILISLAAFLLASQVAVIIALVVLYKKFKTLKQEVHSFKIKKNRASLSALTLKEPNKNRPGNEYVDGQRHPSTLVRTNSGESIVYVPTPAPERRSKNFDDQENGCELNEAANVSSSYTQQQDGEVYGNQVVINMAENGVEANTTYNPSTPCIEDVNINSGYTPDTEEIYGNQVVIDMVSWSSVSNVQTSNVKTTDTNGTKSKKFKAKSASKKAMSQKCKTSIENERKNEDGNSFHEGNNTNVQNDEAIYENVRRQKRSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQQ2</accession>
    <name>A0A6P8IQQ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette sub-family A member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116303237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568598.1">
        <property type="nucleotide sequence ID" value="XM_031712738.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IQQ2">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="GeneID" id="116303237"/>
    <dbReference type="KEGG" id="aten:116303237"/>
    <dbReference type="InParanoid" id="A0A6P8IQQ2"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000436">
        <property type="entry name" value="ATP binding cassette subfamily A member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF209">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1194"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1274"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="498"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1360"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1302"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1673"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1302"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1673"/>
            <end position="1690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568598.1"/>
        </source>
    </evidence>
    <sequence length="1703" mass="189414" checksum="6D5BA3485FFF39BD" modified="2020-12-02" version="1">MSILRQTYFLLRKNFQTKKRHKRLTLQEVIIPIYWVLILLVIRLTVKIKDLPAVSSEQIPRYNLGSQNGGGGGGNVSNMSSKPLVGVVTNNDPQAKEVLFVLKNLSSSRNEYKEFSSSDEMVNYYRTYGESLQFGMGIVFEKENETLSYTLRMSEGIVPDLKTKLVGLGKCHNVKTALHNSFECPANQYISNNIGSFQSFIDSAITKVLAGLPYIVVPNITAQMMPKRAFPQSIGGFELTVPIYMVMAFAPYITILLVSLVIEKEKKYKELLRIMGMKDTAYWLSWFLTYALIILLAVIIINAITVPAGVFGNSNFLLLVIVFYLYGLSLINFAFLLTPLFKNSMTAGTVANLSTIIFGVLLIPLNNPNVPNFAKWIACLLSPTAFSLTLTQAVDSAGITFSNISTKSSFPPSYSIIMMVVDIFLYLGLALYLDAVVPTEYGKRRPPYFIFMPSFWKSLFVDDKNNEIALSRQLSARSVHNQDDVEQVGPEMIGKEVISIHNIKKVFPGKEEVVAVDGFSMDIYEGQVTALLGHNGAGKSTLIAALTGMIEPTSGTALIYGKDITNAEDMEHIRRNIGVCPQQDVLFDFLTVEEHLDLYSGLKGVPGEERKEMISAVIKDIDLEDKTNDIAKNLSGGQKRKLCVGIALIANPKVLFLDEPTSGMDPQSRRQMWSLLQEQAKDKVVLLTTHFMDEADILADYKAIMTKGKLRCAGSSLFLKNRFGIGYHLSMELSNNCDRDTVESLVKSHVEGAEVTRHHGKELAFSLPIDQVNSFAGLFATLEDNNDSNETCAATCLGVTSYGVSMTTLEEVFLQLEDTSDEVKEDNNQPSINGSQNNLLIPTASKENLSGSQASNLHHTGVDLDIQEIRKNEGMSKYTGQLLALLKIQWLQTIRSPLKLFFMVIVPPILLVVGLVLIKVNSSDTGSSLRRVPISPTMYVTPASTQSYATPILFQNSTGSPLDDIYRFLKDYGIDFDQVNSLDDYLNISATEKPSRCFGLDANKFPTNNLSVYPKVDFHLRYNDSMVHSIPVGVNVITSLFNMFALKAKNQIPHPIKTYFQLFPALKPKLKYDNNSFIAVMLIGLSFAVIPGGFAILVVAQRQLNIRHLLRVSGLSTPMYWLYLFISDTIVFIIPAFLLLILVPAIQIPSLSSPAAMGCLVIAVILYIPTGILFSYCLSFLFSKWETCQQVLPAVFTYLSLIPFLAVSLVDMIASPDTAIILHYVFSFLNPAYGLIGAMYYVTRIYLYATIIANSPDVTIPASTYFKWTKHNGIPVTFIAMFVHMILLFFLLYFLDTKNTGRHKSTCSSRSAHKVDRHPSGARSHSSIRSDDVTEDDVKEEKEKILRSDLTDKSSSGFSVAVKGLWKKFGKRKDTKVVVKNLYFGVERGEVFGLLGPNGAGKTTTLNMITGAVAPSRGHVTITGLDMNTESSEIYQHVGYCPQTDALWKDLTLEEHLVLYAKIRGIPTEDVQRTVQHYMSGMRVTEHAKKKSKDLSGGTKRKLSFQMAMLGGPQLLLLDEPSTGLDPSARRFLWNTISKNVKGDRGAILTTHSMEEADALSSRVGIMVKGEMKCLGSTQRLKSKYGSGYSLEIKLTNHSEDAQTKLEAFVKELFPGAVLNEIFGGKATYKVPKDNVSRLSKIFDKLEQGKQTMGIEEYSFSQSTLEQVFLEFAREQDDDRTGEKDKKKEEVEELPPENPSHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQX1</accession>
    <name>A0A6P8IQX1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hexosyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116303868</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-Man]-L-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37667"/>
            <dbReference type="Rhea" id="RHEA-COMP:13308"/>
            <dbReference type="Rhea" id="RHEA-COMP:13618"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:136709"/>
            <dbReference type="ChEBI" id="CHEBI:137540"/>
            <dbReference type="EC" id="2.4.1.313"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Golgi apparatus membrane</location>
            <topology evidence="2 15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_031569339.1">
        <property type="nucleotide sequence ID" value="XM_031713479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303868"/>
    <dbReference type="InParanoid" id="A0A6P8IQX1"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF219">
        <property type="entry name" value="UDP-GALNAC:BETA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031569339.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29846" checksum="837B9AA8C7626FE2" modified="2020-12-02" version="1">MVQGVFPDIEESALEDQHYYTAGTFVYRAYVFNSEEFLEENQSKKQQEAKAREEERSEIVRREEEQLQKEXLEHGDLLVVDAVEVYRNLPRKMLLFYKWASENVNFNFILKTDDDCFLNVDSILNDLKAYGLHDKSKLWWSGFRLDWPXERYGKWREPDYSASVYPAFACGAGYMLSADLVKWLAQNSKALKPYQGEDVSLGIWLSAVGPKLVKDYPRWACSRGCSKDMYTSPENDPQELIELWTNLKQCGDPCGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRC3</accession>
    <name>A0A6P8IRC3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall protein PRY3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568818.1">
        <property type="nucleotide sequence ID" value="XM_031712958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRC3"/>
    <dbReference type="GeneID" id="116303428"/>
    <dbReference type="KEGG" id="aten:116303428"/>
    <dbReference type="InParanoid" id="A0A6P8IRC3"/>
    <dbReference type="OrthoDB" id="5990177at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027642803" evidence="2">
        <location>
            <begin position="22"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568818.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="58474" checksum="A3C73C3CEF8281BB" modified="2020-12-02" version="1">MGVQEHSTIYFLVCLPLLVHSLKQEAVKALDAFQKDCLDAHNTYRAQHGVPPLVWSEELAQHAQNWADQLASRDEVKHDLVAMNKHDEGENLAFFHPAVPKCQGSMEGNCVLCREMIKRWYDEVKNYDYDNGHSKNPDGITKHFTQIIWANTSEVGIGTSVSKKYGFITVARYRPGGNRGGTNAFVVNVPPEGGPLPSLSNYSPKVKPKSTPSTTPTGNGIPVTSPDSSKPPQGTQGSSVIKTLTDTNAVSNKKEVPNTLTGSLDGSAIEKIQTNPMGYGMNDEVENKAPKKSAANLLSMIVDLANKTKPANNDNILNKGATEGNQNQDGPQTLNSAGKPGQNGQEGSSLETIKKDFSYENADSMYSVSNHDSVEGNGGKHGIDSSKTIGIAGSLGNGDHGNVAGITKAQQPHDNYQGQETNSPVPKNGQVDDNKEKSSSEGRTEGNKSNMNDNTPINKEQNDRLNIHTDTGLMAGDNDIQKDLKSKGLVRTVKGPDGTNAQVFLTKNGAHAGLVFRDHISRVSQELKQREFVKNRVINVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRC9</accession>
    <name>A0A6P8IRC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Utrophin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116303924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569407.1">
        <property type="nucleotide sequence ID" value="XM_031713547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303924"/>
    <dbReference type="KEGG" id="aten:116303924"/>
    <dbReference type="InParanoid" id="A0A6P8IRC9"/>
    <dbReference type="OrthoDB" id="5963387at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="158"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="390"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="558"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031569407.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="88142" checksum="62F38194E117F534" modified="2020-12-02" version="1">MASKRPAKPLQNFRTAAIVAKQTQRFSSGQGEREAAHKKAFTKWVNSKLAQRSPPMHISNVVTDLQDGRALLCLLEVLTNRKLKKEKGNLRVHKINNVEQALIVLDECKVKLVGINGFDIVDGKTRVILGLMWSIILKFQVQGVMQQTGSEEESSRSFAVEKQLLEWCKERLKGYDIKVSDFTNSWRDGYAFNAVLHSYRKDAFDFDSLSRMDDKKRLDHAFNQGEKTFGIPRILDSSDVYVERPDKKLIILHVSNMYDYLEGSKAKERSEQADVEEVVVQVDNDQVEGALKPSWDELDSASSRSPEERARALEEIERKLDDLDAAVDDAEDRKPVSKDSNLVDLETSKTHLDRHKKYMRTLESLDSCKYEVFAEVEQTIDEGYCXDKEKDAYYGRMRQIDEKIKALRNEEIKDLNKVSSSYNLFLSENLXKIEKSVENSEKKIKSTKDVANDYDTVNKQLEEHQEFQEEMGDPTVVNTILEIDASDPSVDSATRNRLKALSQRWKAIWDWAEDRKKKLMSSLSDWQKFRDEELVVLNWLGAKEKALKEINKTDLMDEQAANKSAQELERIQKELVDEEHRLDYLHECXEKLKREAGEDKEAIKDIDKQLKDFDDCWNDIVKQVIDGKEKVNNASNKIKEMKTKMKEVNEWMDDARSLIEDVSDEMSPEDMDKLKDKVELKCDERPQIQLRVQRAKRLSNDVMPLLNPEFSKKLEKEVEDFEGKWKDTNAALEGFSDKGYSDATSDCCLMRVIKRKFKSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRM9</accession>
    <name>A0A6P8IRM9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116304109</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031569629.1">
        <property type="nucleotide sequence ID" value="XM_031713769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRM9"/>
    <dbReference type="FunCoup" id="A0A6P8IRM9">
        <property type="interactions" value="3185"/>
    </dbReference>
    <dbReference type="GeneID" id="116304109"/>
    <dbReference type="KEGG" id="aten:116304109"/>
    <dbReference type="InParanoid" id="A0A6P8IRM9"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16704">
        <property type="entry name" value="RING-HC_RNF20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000040">
        <property type="entry name" value="E3 ubiquitin protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058642">
        <property type="entry name" value="BRE1A/B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26052">
        <property type="entry name" value="BRE1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="884"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="162"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="524"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="757"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031569629.1"/>
        </source>
    </evidence>
    <sequence length="936" mass="109048" checksum="96A5B9D03F6A6789" modified="2020-12-02" version="1">MKRSQPEPSTSAPPKKQATTRMLESVNVGPVSTEDEMNIQVLAFQNKKLAERLEVMKLDEERLRERLDEVKKQRVAEYEILSLINRHWTQLDEDVSVMCQSYESGTAEEFGDLNDTALSYLEYLAQLEPEQMKEEVSKRAANSKQCVKTLLSFMEKAGCFPPRVPASSQVIPPGETSSTGEVTKDDDMETDELKETDEGQVIKESDDGTSKTEPIVEKKQEETPKKEELETSSKEPEIEQLKSDNKRLRELMTSIQLKQQTTSLEFSEIRDKYALTNREISELNTQLQDSEYDLQKANHRVENLVKRLNELEEMRKKIREGEMPAKEEIKDEDDEKHSELLELKELAKNRLEELQKLKEDCVAAQQELEKLKLEAVQIPESTIVQSSPYKCLQSQFSVLFNETTNARQQLDELRRTLSSTKTQHMVQLEQIESDMITTHKKYKSEVNELHEALLHCKREYDLLRIECDQSTKTNEQTAPLIKETTYMNNSLQSYNKQLKGEVMRYKRKLNEALSQTQKLEEEISKLRETKPKEEQVKKEEEKTEEEMEVKQEQESKETPKEPEEGEEGELEEGEEEEPAKSSNDSEQVKQLQASLKKAQESQKEMKLLLDVYKGAAKDLRDKVELLASEKTLKIEIEALKNRVKELEQDLEKYKGAMADEEAIRRLKVAEETIENLQKNLAATKQEEDALLAEMEFTGQEYVEMQEQNVRLLQQLREKDEANLKLMSERIKSNQIQKQIREEKDVLADQVTSLNTYLETQTQLIKKQEERERSLQNAVGSMEKELSLRQQAMEMHKRKAQDNCQSAQELKIRLEAFQQQQQETQESIAEKTRSLEEEAFRAKRVQEECNSLKRKIEKQKKIDLYGAADEVLLEEVRQYKARLTCPCCNTRKKDAILTKCFHVFCYECLKTRYDTRQRKCPKCNATFGNNDFHKIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS91</accession>
    <name>A0A6P8IS91_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TNF receptor-associated factor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116304208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031569762.1">
        <property type="nucleotide sequence ID" value="XM_031713902.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IS91">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116304208"/>
    <dbReference type="KEGG" id="aten:116304208"/>
    <dbReference type="InParanoid" id="A0A6P8IS91"/>
    <dbReference type="OrthoDB" id="5946831at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031569762.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25826" checksum="EF80008F68FED6DF" modified="2020-12-02" version="1">MGYKPEQFLKNVDENLFCSICHEIFQDPVSXKDGHTFCSECIELWLKTSRNCPLDNTAITDSKLVRNLIVCNIVDNLYVYCHPQESEQNIEIKADKNEELKCDWTGKLQALAKHRETCPFQQVQCPNVDCNTNMQRRELEDHDKICLFKMVFCDRCRIVLIRHELDKHHDSYCPETLIVCPNNCTFIRDQVIRIKRIDLINHLTTTCAKTILDCPFKDQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISP2</accession>
    <name>A0A6P8ISP2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and SOCS box protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569243.1">
        <property type="nucleotide sequence ID" value="XM_031713383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303780"/>
    <dbReference type="KEGG" id="aten:116303780"/>
    <dbReference type="InParanoid" id="A0A6P8ISP2"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="357"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569243.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46956" checksum="2424E3E700BCE9DC" modified="2020-12-02" version="1">MAENRCFEAVVSLIEDVLVKRWFSDLSWIKKATWDDVYHSVRERQLHRVKQILVNIFGEDNYKEKIDDKTLQXLCCIVKEIESHSVAKRKHFLDRSSCCVLALLSIVLEQCQDDSTINKHQIEIVLNTCTNNTVKLXELLSMDNLSSLEDMVTTCCKGMTPIHFAVLWDNIESLQVLLKYVANTELINHKDLYSYTALHYAVQYPSTTAARMLLDYGADVNAQLQFGHTPLHLAAFRVDPKLVLLLCRHGADVSAVTSLGETPLTTATRLGSXSRVEHLDLHLTTISLLLRYGSSPNAHDKQGRTPIFYGWRFSQDKRCALMLCSAGANLAFLPKNCTFESNSVIPLNTSQECLMFMFRRFLETVGKTPLRLEIICLIEVRKAMGKSFQQGVQELPLPSKLKQALLFQTLPKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITM0</accession>
    <name>A0A6P8ITM0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanylate-binding protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116304723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570359.1">
        <property type="nucleotide sequence ID" value="XM_031714499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITM0"/>
    <dbReference type="FunCoup" id="A0A6P8ITM0">
        <property type="interactions" value="1000"/>
    </dbReference>
    <dbReference type="GeneID" id="116304723"/>
    <dbReference type="KEGG" id="aten:116304723"/>
    <dbReference type="InParanoid" id="A0A6P8ITM0"/>
    <dbReference type="OrthoDB" id="2135133at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="6">
        <location>
            <begin position="58"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570359.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62432" checksum="08C12E41E412891F" modified="2020-12-02" version="1">MAKYALPYWRILSAIPLVLPNDYTWEERTETCRKKLRSIKRTGLAVVPKALEQLRKIKGPVCVVSIAGPCRKGKSYVLSKAFDQGEVFSLGHSMTPETMGIWMWIVPQKFKDRKGRDFTLVLLDSEGSDSPNAKQEEDYGIFTLSVLLSSILIYNSVGVANRSDLENLDFVTKLTQRIQLNASKKKNVFPNFIWLLRDVVLTLPPGCNTIRDYLLKNVLSTKGKAGSSEKAIHAADSILNLFSGFDAFSLPPPSFNPEVGAQCEEVHVQRKRTSICLSKRKTGSVQFSSVQSHLSAFSSIPSLALATLVELYVKALNTSGVVPNVENAWDSFVRNKCTEVLAAAVNIYQQDMTSRLKDRIPCEDDVISKAHKKAVDVCLVTFRTETSALSRKNIDKYTQQFREKTNPILSKWTKQNTCETEKYCTELFKHLKQSLLDPVLQRLQGPEGFKMQISDIVSAYNKIEKSYEAKARGAKDVQTTMLMNFLPELDNEMELNIAILQSMKDKNESLERQRADREAERRRAEELITRLETEKKNRERQVINECPKHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITN0</accession>
    <name>A0A6P8ITN0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulation of nuclear pre-mRNA domain-containing protein 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116304736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0400 (RTT103) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570374.1">
        <property type="nucleotide sequence ID" value="XM_031714514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITN0"/>
    <dbReference type="FunCoup" id="A0A6P8ITN0">
        <property type="interactions" value="3285"/>
    </dbReference>
    <dbReference type="GeneID" id="116304736"/>
    <dbReference type="KEGG" id="aten:116304736"/>
    <dbReference type="InParanoid" id="A0A6P8ITN0"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001111">
        <property type="term" value="P:RNA polymerase II promoter clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17002">
        <property type="entry name" value="CID_RPRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000007">
        <property type="entry name" value="Regulation of nuclear pre-mRNA domain-containing protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032337">
        <property type="entry name" value="RPRD1A/B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16566">
        <property type="entry name" value="CREPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570374.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35262" checksum="EEE1CCAE1E10C6C9" modified="2020-12-02" version="1">MTSFSASTLEKKLNDLSNTQQSVQTLSLWLIHHRKHAKLVVQTWNKEVHRAKPAKKLTLLYLANDVLQNSKKKGSEFNAEFKAALPSVFKHCSQETYKDATVKGMGRLLKIWSERGVFELSYIEKLRKLTNYEPPIEASPPPSKIARLDSASDEPAEPPDAEELIKALQELEQSASQDAVVREKIANLPAEVQDVSLLEKIEDKETGDRLTRIVDKACVLLAEYNGRLSAEMEDRVTLSKMLSSFLALQKDKLAETEKRLEEFRAKLDKVTMVRKELKSHLDNLPDLSKLPDVDGGLPPLPSAGDLFASSSGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU21</accession>
    <name>A0A6P8IU21_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS-associated death domain protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570746.1">
        <property type="nucleotide sequence ID" value="XM_031714886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305054"/>
    <dbReference type="KEGG" id="aten:116305054"/>
    <dbReference type="InParanoid" id="A0A6P8IU21"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016729">
        <property type="entry name" value="FADD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077:SF12">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077">
        <property type="entry name" value="FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570746.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17368" checksum="C2F40C96C8AC9348" modified="2020-12-02" version="1">IDWPLFISSGHVDEEQWVDRIKTILSDEEISHLTSVYILXPSSAQPIPHTQSHSSPIPEEIIXRISSKIVEHNWNQLAQELGFTDQDMKVLEKHFPNRSREQVYQMLKHWREKEGSTKQALESALKRCGMDDALSVLQNEAVGQLSSADQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUT2</accession>
    <name>A0A6P8IUT2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 98</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116305108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM98 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570804.1">
        <property type="nucleotide sequence ID" value="XM_031714944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUT2"/>
    <dbReference type="FunCoup" id="A0A6P8IUT2">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="GeneID" id="116305108"/>
    <dbReference type="KEGG" id="aten:116305108"/>
    <dbReference type="InParanoid" id="A0A6P8IUT2"/>
    <dbReference type="OrthoDB" id="5978425at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029668">
        <property type="entry name" value="TMEM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32510:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031570804.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27135" checksum="F2D65492D5C6AD4C" modified="2020-12-02" version="1">MALVMITAIALLAVIFMASFVGLMVICKHKCGKLDFTAQRSEAGYPKRVSNKKQVELIGANFNINADFGRCLSNEDLSGIFLDPDWQGDAERLIGHCVELLKTCHELTEKLVAYTVENGPKIKSQDGMKQIMASARHIGPKVDELVEAMYTPSDSRQIEEKSSALYLAVHLLLQVIKSVSDQPEQLHWADDVIHLIEQHIEEMRRDSQPDPNLLEAVGNACRKNEPVTGSKQSRCFVNRTFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVD2</accession>
    <name>A0A6P8IVD2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Serine protease 23-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116304489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570090.1">
        <property type="nucleotide sequence ID" value="XM_031714230.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031570091.1">
        <property type="nucleotide sequence ID" value="XM_031714231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVD2"/>
    <dbReference type="GeneID" id="116304489"/>
    <dbReference type="KEGG" id="aten:116304489"/>
    <dbReference type="OrthoDB" id="10037376at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF8">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653240" evidence="3">
        <location>
            <begin position="24"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="108"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031570090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570091.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38586" checksum="8EB08F0C1473CB17" modified="2020-12-02" version="1">MCPTKSEICFIMVIMFIGTLCNAVPVHENFISTIRNFKSKSIMKTNSSKESTGMPFVMDFDIVEDSKDEEQLLQKILYRVNVFNPHGQEQKSRNLPMTKLLSRSKRSIFGLDDRNLVETSVKAQTYPFSTVVYLSSGCTGTLVGVRHVLTAAHCVHDGRKFLKQAKHLRIGMLGSYGTFRWIKVDKIHLPKQWKSTNRRRRVQHDYALLRLRRPHSRPIMAIKPSTLKRGSPMQFAGFHSDKKRNAMWLSQCTVAVAIQGGILSFCDGAKGISGSGVYVHKGVSNGDAIVGVVSAIGKGRLRGRTQLFNLVISFTPKTVRKVNKWMKKSKRQRKVKIKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVJ4</accession>
    <name>A0A6P8IVJ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exocyst complex component 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571124.1">
        <property type="nucleotide sequence ID" value="XM_031715264.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IVJ4">
        <property type="interactions" value="1900"/>
    </dbReference>
    <dbReference type="GeneID" id="116305370"/>
    <dbReference type="KEGG" id="aten:116305370"/>
    <dbReference type="InParanoid" id="A0A6P8IVJ4"/>
    <dbReference type="OrthoDB" id="10047020at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000001">
        <property type="entry name" value="Exocyst complex component 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031571124.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="88060" checksum="C67D92F6934E20AB" modified="2020-12-02" version="1">MSIDIQKAKAEAHENAAKHVATMLQNPDSLDKVEQWRRRVMRNKASVEARLKSAVQSQLEGVRTGLGQLQSAVEDIKQIKQSMAEVDDMLKGVSDLSDKLEVVKATQYKHTQLSKACEHLNHIFNVPENVEKTKTLIAGGKLLMAHKSLTDLEGTRDELLYEVHKMSTTEGGTKTDKTPLNKYFSELTKLSETLGKQLWIVMQMFLSTVRSDPDQLVTALRIIEREERADKRAEEKLASTGFSVPGRPKEWKKKCFDVLERAIAYRLESLEMHLEDRLSAKMWLVKHLERSRKQVLEDLIIVKSLCQPCFPPNYDIFDKCVRMYHKALSAMLEKTVTEQRLDSNECVSLLTWISEYGGIDLMMHPELQVDVACLDPLLSKSVYKNLVETYITTTSNNIKDWMGKIIETDRKDWHNSSLPEADGEGFYNTSLPIFLFQMVDQNLQVAAQTGEELKLKIFDICIEEMQDFQRGYRTAIREFKSKHXEDRSLPPRFIEYMIAIVNNCMSSIKFTEQLKDRTLAEVGKPTFGEDRLQIFKSIVDCYNSIGQDGCRFLLEEVFLDLEPFFAQIMTPNWVSSPTQVDTIIATIEDYSSDFAHLKPTFFKYTMHHALEKVLLEYVRAMMNKKLAFKSYEERKEAAKKIADEAKKFENLFKKRTENAEEVENQCSVLPALAEVIKLQDTSMMALEISGLAAKYPDLRSDHAMALLLMRGDVWRNDAKEIIMETSLADSKRENQEGVDKGFFDQIIVPPSLLDKLETAMKSKLSKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVR2</accession>
    <name>A0A6P8IVR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Negative elongation factor C/D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571376.1">
        <property type="nucleotide sequence ID" value="XM_031715516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVR2"/>
    <dbReference type="FunCoup" id="A0A6P8IVR2">
        <property type="interactions" value="2831"/>
    </dbReference>
    <dbReference type="GeneID" id="116305577"/>
    <dbReference type="KEGG" id="aten:116305577"/>
    <dbReference type="InParanoid" id="A0A6P8IVR2"/>
    <dbReference type="OrthoDB" id="511287at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571376.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="65152" checksum="95F38022810A708C" modified="2020-12-02" version="1">MDDYGAENGWEEAAPLSPTDERRDHDTSFQDLEHIFATKDFVMEPDVFSHIRRYLLNAGSHEELIKLLSENYRGIAQSANLLANWLILTGADVHEVEQMVEDHLKMLIIKHFDPKRADSIFTEAGETPPWLESMIVHPTWRSMFYKLAEQYPDCLMLNFTIKLISDAGYQGEITSVSTACHQIEVFSRVLKTSVNGFIEEGEMAMETNMPEFAKMVNHGQHTYLYAQCLLNAVAQEERGGIMVKRICQEVRKKAIESGRDVTQITLCLNGAPSFPRVCSALSSMLGKNTLNPGDITVLYKLYNNEQPPPCELLRIPQFLDLLIDALFKPNQQINREHKFKYIYLLAYAVCVHETWQENERVSLNIDELKATSQAIDKVHNMCMQESSGSSHLSSEVGTLFQCIRYPVVAMGILKWVDCTVNDPSFFKLMTDSTPVHLSMLDELVTCHPPQHRLVLNLLIRLFESPTPLDTLVELEFKKTVLDRMVHMLSRGYVISVLSYIHKCMKGQIVDNSLIRHFVTEVLEMIAPPYSPEFVQLFLPIVQNKEITGKLRKNKGSDDVSSFIAHCSARDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWZ6</accession>
    <name>A0A6P8IWZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116305831</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116305831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571664.1">
        <property type="nucleotide sequence ID" value="XM_031715804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWZ6"/>
    <dbReference type="GeneID" id="116305831"/>
    <dbReference type="KEGG" id="aten:116305831"/>
    <dbReference type="InParanoid" id="A0A6P8IWZ6"/>
    <dbReference type="OrthoDB" id="6020478at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019955">
        <property type="term" value="F:cytokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050379">
        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF151">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028303495" evidence="7">
        <location>
            <begin position="21"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="127"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="227"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="332"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031571664.1"/>
        </source>
    </evidence>
    <sequence length="889" mass="99051" checksum="7B695203090A7C9D" modified="2020-12-02" version="1">MPKTSISFCYVLFFYSLSSCEQDDFQAVFVVKLIGEMWNNILLTKDSRTNMLVDKITSNVKVFYNGDNSFREVTVHSFRKGSVIATFSISYAALGSIQILKIQEHVTMTGKISTIPAKILNISSDKVPNAPTITSASSFNSTSIQLHWTSISDAGGMGYLVYYKQAGSRFDPVQFKSVMLAVTQTVISGLREFTGYTFRVLASSSNGNGVASEPVTISTDEDVPSVPPSNLKLIVYSSTRISLLWDAIKDSQTNGVLLGYNVSLTWRDKMDNRLRGSTRAVQPTGGSVILTLKYLLKFTIYSLKVCGFTSKGCGPWSNEVHASTLRDVPSQPPSNITYKNFTSTSSATIHWDTIPLGHLNGILQGYQVTYKQIMQSELPVEEATDVTKNLGPNSSSLELNDLQAHSIYQVEIAAVTDAGIGVAHTIFLETCRCPKTLYTNFWVHPPYLNQNTSTGVIDGIFPNIVTQMLTWACGVCNNGHGDTILNMTSNGRDMTSLKDSVVGVIEDIDDVPQVSFPIYGNEDIKEYKGSHQYVKVVDSPGIAFINVRQKPKVMNLALACLPLIGFVLCITYISGFIMWLLERKSNNGQFHENFSKGIIDGFWWSFISITTVGYGDRVPVSRLGRLFGVFWILTGLVVISVLISEITNSFTTLCMSTTYNDHLIYGSKIAVIKNSVEYRVGTQMNAIIDKEYQYYSIDDIHDALQNGNVFGALIDTYVAADQKDHLFDENIKVNKLLEKKIGYGVVLSGDAKVVQKRCNDFMKRKVEEISKVIQNYTSTLEFQPPEENESTEKSSNLFEVESATFKMALLCLGLLLSMAVIGGLILHVILLKRRTNKVDRAHSRQVVINMRNEMRQFVDVFYQDIKAKISDLKVKHRQEIAKLVQLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX96</accession>
    <name>A0A6P8IX96_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 and PX domain-containing protein 2A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570663.1">
        <property type="nucleotide sequence ID" value="XM_031714803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IX96"/>
    <dbReference type="GeneID" id="116304988"/>
    <dbReference type="KEGG" id="aten:116304988"/>
    <dbReference type="InParanoid" id="A0A6P8IX96"/>
    <dbReference type="OrthoDB" id="5982329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF27">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570663.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26532" checksum="BC8958E944A6121C" modified="2020-12-02" version="1">MKLAKNAVSIRSLPGHEIKMELRLPIDEKESATTLLYVVTANFVAIKERTKDKKKQYVFVFNVDWSDGTSSVVWRSYSEFFDLQCRLLDSFPEEAGSKRRARIIPYLPGRQIFKKSDSHLAEERRPHLIKYTNEILMLPKNISQGPIVVSFFHKRKGDPVCFNQFPSKLNTKLEFQLWTSPTKEEIQQPETNEVNDSENQDGHDAFGQVNLSYERSLSVGNRNYIKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IY41</accession>
    <name>A0A6P8IY41_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116306449</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572376.1">
        <property type="nucleotide sequence ID" value="XM_031716516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306449"/>
    <dbReference type="KEGG" id="aten:116306449"/>
    <dbReference type="InParanoid" id="A0A6P8IY41"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23417">
        <property type="entry name" value="beta-trefoil_Ricin_MytiLec-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572376.1"/>
        </source>
    </evidence>
    <sequence length="816" mass="91439" checksum="96E817526140AC7D" modified="2020-12-02" version="1">MAFLWIFRPLLRLYFRHKRLFLLTVAVVVIFSAFFPFPVRKPLSSVQSVMSNIISNPLGSARDKATVKKTDIYIPEHEFHFDDVKDNSLSLFGSSQCLLLDLDPFNEEVTKNQKDLGELKCSGPEATKLEGGVLSVKGTGLQEVTYQAIQPSEDPKASFVLGDRMAVITAQVQLTPGGSDSIAHFLGKCIHSYGGNIRPGSQLVLYDLCGEDRLEFTLEEDGTLRHKMSGYCVGPKAEIAQSNKPLTITDRCDDSTKFKGLENGFLQHMSSEMCVHFQSLDLDPPNDVPLVFYADCKENWKMRFGWASDFKKGKNKKTDINTDVSDDFIQVSVQYADALPSQQHMEYHLQVSPKFSLQEPKDAHLKPNMLILILNSVSFAHFRRKLPKTYAYLNQLAGTVFFKGFSVFDDSSKSQLAAMLSGITPNNIASHNSFDELPWIHTLHKEQGYATLFSEDLPCSAQYKDTLCGFSKSPTDHFALPFWSAVHQTYSRGQNTFCLGQKAIHNITFSYLRDFMTIYTKLPKLAIAMLSELSSWNPNGLGYMDKDFARXLAWLKVEGHLDHTMITIVSEHGSRSELLRKTLQGKLEERNPYLSITLPPKAPKVLLDAIPNLKENSKGLVTPYDLYSTLRSAVPSIPRRAGGMGANLLEPIPDTSKRSCEDLGIPKQWCPCLSVHKIDANIKVLQNAARKVLQHVNKGISEDPKMADVCQKLEFSKIKAATTLTPNNEVLKFKWSKDAGHCTNCEPVYGAKTKSMFYVLYVEAKQGVTIRAIVNISNGKEYIHPHVVSSQTSKMTSCWATEKGKYSQAWKMCACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYB7</accession>
    <name>A0A6P8IYB7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THUMP domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572169.1">
        <property type="nucleotide sequence ID" value="XM_031716309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYB7"/>
    <dbReference type="FunCoup" id="A0A6P8IYB7">
        <property type="interactions" value="2602"/>
    </dbReference>
    <dbReference type="GeneID" id="116306285"/>
    <dbReference type="KEGG" id="aten:116306285"/>
    <dbReference type="InParanoid" id="A0A6P8IYB7"/>
    <dbReference type="OrthoDB" id="47730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000073">
        <property type="entry name" value="THUMP domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF13">
        <property type="entry name" value="TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="THUMP" evidence="6">
        <location>
            <begin position="103"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572169.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="45806" checksum="B8F2C53ACEA10D31" modified="2020-12-02" version="1">MVDEECRTCLLCGTVVTGFEAIAASECTEKLNCKPTKKQGKMYFEIPVESVEKANKLCSVEHLFVVVKKVEDFGISNSDEDKETVLNRFGQLVNEINWDQGLEIWRDCTNYQGPLKLVEKPRDSSADDADDNSTCNESVSKKAKTEDFSSLPRFRVTCARTGSKHSFSSMEAAASFGGAINDLFHWRVDLSNADIEVLLNITNNTLVIGIALTRQSLGKRNIQHFGPTTLKSSIAYCLLHLACINPGDIVCDPMCGGGSILIEGVLNWPMAAHFCGDNHELATARVLANLKCISEDEKRCFPQDIYQWDTCNLPLRTSTVDVMVTDMPFGKKSGSRQLNWTLYPKALTEMARVCPPKTGRAIILTQDKKVMKKALNQVSQWWKVKSTLWINMGGLQAGVYVLLRSEKSLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYP5</accession>
    <name>A0A6P8IYP5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 135-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571068.1">
        <property type="nucleotide sequence ID" value="XM_031715208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYP5"/>
    <dbReference type="FunCoup" id="A0A6P8IYP5">
        <property type="interactions" value="739"/>
    </dbReference>
    <dbReference type="GeneID" id="116305321"/>
    <dbReference type="KEGG" id="aten:116305321"/>
    <dbReference type="InParanoid" id="A0A6P8IYP5"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571068.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48162" checksum="D41C440E830F1095" modified="2020-12-02" version="1">MSDIPLSLEAIRQLLTPLSCTDTCYEIAHTWTPSCFEGCFSIFRSIMRESLKIYPPLYLVAAILRKEKFEYFTQRFFLDVLQSALAIAVNGSFFVGWVCVVRKCLGKFYFLSMGLLPGFLASVMGINVERKERRGILSLYMFNLAIEMIYNVLKKRGYIIPVPYGEVWILCVTSAIMMYLYRSEDGLRRGALKSLIRFFVGSQGPENVKGIKNNQNVPPQICNRIQYQLSLDCIKQSLKAFTVGFVLQLLPQLPKAFRTPSNFPQSLYSPDNFKCGLFLGSYVGIFKVVEYLLAVYRKRQDNLNALIAGGLSGLSMMFYRSSTIALYLASKIGEIMYKRGVRQGILPTIPHATIWVYSISTALIFHSASFEVDTVRPSYWKYLNQVTGKRFCEINRQRLGDIFGLDSAKLFPPDDLYMSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J079</accession>
    <name>A0A6P8J079_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116307211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573226.1">
        <property type="nucleotide sequence ID" value="XM_031717366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J079"/>
    <dbReference type="GeneID" id="116307211"/>
    <dbReference type="KEGG" id="aten:116307211"/>
    <dbReference type="InParanoid" id="A0A6P8J079"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020863">
        <property type="entry name" value="MACPF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742">
        <property type="entry name" value="COMPLEMENT COMPONENT C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742:SF8">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00279">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027998049" evidence="7">
        <location>
            <begin position="20"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="8">
        <location>
            <begin position="78"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573226.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="81523" checksum="1ECDB9228EDEA79D" modified="2020-12-02" version="1">MTLIKGHLLLLILACSSFAKTPEELLDSLRAKQIQAMVKEQRKSIELQVPEELAKAACLEAKKRILSAESDIFEINATPYSPFSAEKSTKNLGFLGRGYDVLFGNPLDESGRVDPGFRLQAVELGYLQNRFSADGEYRIPDNADVIMEPSALFSSSFNDVRTESDYKQTLKEDVKTTAGFGFDAGFVSVSGEFSQSKSYQSTKESIKKGGKVNIDIIGRATAYKAWLHTVGTEMHATKNLQKAIQDLPTECSKSNLSYYYRLIQNFGTHFTTVVTMGAKAVQRLTMTTEESMDLKRKGISTNQVVSASVGFMAKGVSASAKFGKEESSSSDTTLSDTLKNMNIQKREFYIGGEPPSESYSIDNQASTASLRQWGRSAFERPVPIQYELQQIISLFAKKYLPDVEEKGIPEKRKCMEDALSTYCTNVAIDKEECIAYKDGDGVKDVIRYGDFISIKKLTSKSSNKYLTVDKDFPKFIQNTKAQDFKIVPVDVDSFWKYGKALHYQEPFNLVSEYGGQQGIVECFSSAENSKNYNLFNYGKQRVTCTREDNPVGVWEEKKGYWCKKKGIESLTFDDLTVEECKRKCLELTNGECKAVQYFGDSRSSTCAHCDNLDDIEKHGKLVNIPTPGYVYQRDAAKKLAERHAFTSTLYLTPPNTKKKAGSLVMKNDQVYIGVSSYENRKQLYDVRRPAFLGVLSDDVQVKQDSGTTINLSEINCKDGLKNEDIQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0X6</accession>
    <name>A0A6P8J0X6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA ligase 4</fullName>
            <ecNumber evidence="4">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA ligase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Polydeoxyribonucleotide synthase [ATP] 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116307123</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031573134.1">
        <property type="nucleotide sequence ID" value="XM_031717274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0X6"/>
    <dbReference type="FunCoup" id="A0A6P8J0X6">
        <property type="interactions" value="1629"/>
    </dbReference>
    <dbReference type="GeneID" id="116307123"/>
    <dbReference type="KEGG" id="aten:116307123"/>
    <dbReference type="InParanoid" id="A0A6P8J0X6"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000150">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000027">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000044">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021536">
        <property type="entry name" value="DNA_ligase_IV_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11411">
        <property type="entry name" value="DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="20">
        <location>
            <begin position="302"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="21">
        <location>
            <begin position="606"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="21">
        <location>
            <begin position="762"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031573134.1"/>
        </source>
    </evidence>
    <sequence length="866" mass="98543" checksum="99968C482365755F" modified="2020-12-02" version="1">MFENETDSLYPGIRLLLPHLDKDRPAYGMKEVVLARYYIEILSIGKDSTDGRKLLNYRHPGASKQGALGDFASVAYFVLKNRCPEKGSFNVEQINKHLDDIAQANLEKKRDEVKKSLQILLRNTTAMEQKWLIRIILRELKTGLSENSVLGVFHSDALELYNICNSLSKVCQDLHNPTIRMNEVEISLFSPFRPMLGQRGSLNQVEKVMEGQPFYIEEKVDGERMQLHKGNNTYKYFSRSANEYTHIFGESADEGFLTPHIAESFNSSTESCILDGEMVIFDPSAGTFFTKATNHDVKSASTYDKGFHPCFIVFDILLLNDRKLANVSLQERIAVLNTVFNPRLGYIQFVERKNGTSKTEIISALNEAIDRREEGLVIKAPSSVYKPNVRNGSGWLKIKPEYVDSLSDELDVLIVGGYFGVGIRSGMISHFLCAVAVPPDQKGQHPSQFYSFCKVGTGYTLDELRELGNKLKPHWQPFKTNKPPQNIALAPGFKEKPDVWIEPSKSKIVQIKAAEIIASDRYKTGSTLRFPRLECIRDDKHWYECLDLKELEKLRTMAEGKLTYQHTDMDGTSEPTRKKRRVAARVEQPRTVAAHFRPADVSSVTEVSKLFAGKEFCIINGPTSEPKAQLEKKVVEHGGTFTQNPGPETYCVIAERVNLRVNNIIKDAKHDVVKASWLIDCLNQVKLLPWLPIHMIHRSPTTEEKFAMQYDSYGDSFTQDATQESLKKVFGSFENQEKATITTDEIAEIEQRYFPDQCPLGLFRGSRIYLDQFKSLDDPNTAIKDSSLELTALQLRFYGASIISEFDEIVTHVVFDERDLTRLPELRQIMRSRQQKHHFVTQDWVTQSIEKGQLLQERPFAPVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1T8</accession>
    <name>A0A6P8J1T8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116307719</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031573876.1">
        <property type="nucleotide sequence ID" value="XM_031718016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1T8"/>
    <dbReference type="FunCoup" id="A0A6P8J1T8">
        <property type="interactions" value="1244"/>
    </dbReference>
    <dbReference type="GeneID" id="116307719"/>
    <dbReference type="KEGG" id="aten:116307719"/>
    <dbReference type="InParanoid" id="A0A6P8J1T8"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031573876.1"/>
        </source>
    </evidence>
    <sequence length="726" mass="83760" checksum="F3A553479E29ADD1" modified="2020-12-02" version="1">MADETSKSDIVWKNVQETATKCSVSDFFDSVQVWIDKPQVVNRRLSGSLDVKHAFLPSENVDKLYKLLHHQRSISAWCRLVEEFAIPASSHEEEHEGGRAEVLLRRVLPRQIAKYRTLFELVIKDRSTSSISFIPIFMEKCEENDSSESEWEMTAYRFLHLQDINNKPKISLQVSCSVIDRRVQDINRSDCVVCPSIQWMKDHLLPKLKKWAENPQKQSKGSLRLISLERYTLLYQELKDKHGLELVKNWPENTDPQKFVYEDIAIATYLIILWEEEREKNNLKEKQSFVDLGCGNGLLVYILSKEGHPGLGIDVRKRKIWDFYGPGIKLEERPLDPTASGLFPNVDWLIGNHSDELTPWIPVMAARSSYRTRYFVLPCCFYDFNCKYVRQNNKTSQYRGYLDYVHKIGVVCGFEVEEDMLRIPSTKRICHIGQSRTYPEEDHEEMEIKIKAMIRERGCNIDEGQQPQTMVNTTRISKQASGDHSTEYENDNNTDGTRHLLDQSDRAYESNGAREDTGSPAAKKIALETEAHQIKTSDFKPREQTITVRNCSHLSKSLKEFIVNSVAEALLQESDSEGPKDDKDKFEGTSLNRFTSKGVLLDLWNRGRSLKLPDVAKLFDNETLKKMKNECGGIQTLLRNHRHIFQVVGGVVQLRDWRKETPGPKLTPNADVEFLKRRFDALGNTSMCWFHFNHPDGCTLLTEQCPYAHSEDELVVRPTTQYLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J278</accession>
    <name>A0A6P8J278_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571795.1">
        <property type="nucleotide sequence ID" value="XM_031715935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J278"/>
    <dbReference type="GeneID" id="116305934"/>
    <dbReference type="KEGG" id="aten:116305934"/>
    <dbReference type="InParanoid" id="A0A6P8J278"/>
    <dbReference type="OrthoDB" id="300500at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042814">
        <property type="entry name" value="Morn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571795.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32008" checksum="82DD7B92C7619767" modified="2020-12-02" version="1">MILHLGKHVLRFHFHNPRKFTYTVSFSVLELRAHSWLHNKRHKEFLVVSVFKVILNNQYWQSLQSCINMIPAMQYTGSCYDGDFTNGRMEGECEYEFPPLFGTKYIGQIKDGKLHGEGTIQISDLLWYVGKFEDGKSKEGKYEFRDDGLTYDVEKKWEYCNGTTDRLFGLELRDGVKPAGRSMISNRVPPQQIPRGMYDSGEGFYDPIKRVIYTYEMKFFKSADDEEHEWIVKKCRKAEDNEVDDADDADKPSVENQKSANDKKARKKTFTNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J394</accession>
    <name>A0A6P8J394_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI ethanolamine phosphate transferase 3, catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphatidylinositol-glycan biosynthesis class O protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116307926</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574112.1">
        <property type="nucleotide sequence ID" value="XM_031718252.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J394">
        <property type="interactions" value="1716"/>
    </dbReference>
    <dbReference type="GeneID" id="116307926"/>
    <dbReference type="KEGG" id="aten:116307926"/>
    <dbReference type="InParanoid" id="A0A6P8J394"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000041">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="867"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="979"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1083"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="944"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031574112.1"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127023" checksum="D4A579378981399C" modified="2020-12-02" version="1">MGYGLKLAAVSTCLTLIFVSGVLLFTRGFLLKRLVIDDKTKCNEKINGKTMPSSLFSKTSSSGCWVETKFEKAVILIIDALRYDFAYFDETLQDEDTLTYQNKLTVIHETLKALPQQARLYRFIADPPTTTMQRIKGLTTGSLPTFVDAGSNFASYTIKEDNIISKLVEHGKNITFMGDETWQGLFPDTFQKSYPFPSFNVKDLHTVDNGVIKHLVPEIQQENWQVLIGHFLGVDHCGHKYGPYHPAMAEKLQQMNNVLRSVMDALDDKTVLFVMGDHGMTRTGDHGGDSRDELDSALFVYSKVPFIDTHQPKIDANSVSQVDFVPTFSLLMGIPIPFGNLGTTITELFAGQDYQPVIPSYVPDEKRHLWKSLLTRVKVLQVNAYQINKYLQKYQEISDEIPKRKLSSITSEFVEVSELWQDTRDQNNINGSTAAGHLSVERLLLMEQKYLKYLTGVKELCIEMWAKFDLISMTFGVLIQIFALSLMTMIILIPSLLRKGASVILKTSVVLSIIGSCCCAVISATDSHTVIYNSFVCCVGSLAFIFAHFIIAERTKLYAKVKQVIRIISLEDIISTVLCLLYFLSTFSNSFVVYEDMCVTFITSSLLSLQLILAFLKNRTTQTIVRILPRKTLGGNKKAKKETQKFDVWSFFTSSNCQAVLALLLFVLCGRLSSVFRRCREEQVSCEPSSFLQPLSALKDATESIHQRFLLSTICACALPLGLRQWXRFQGNLNGFSSAVICVKYGLPFATAVTVAHWALQIIPQAANDAFPNLQLWQQIILPEVVYWLCLLTISLLLWQPLCLYTMLRDSQSSLKDSINSYLNKDNNDPKTLQVVFNELRKKWDSNSSQNTGDKTVIDPEKNQPPVVYGLATVYSSPILIVVTCVAMTMVVILSDGMVGSVLLLLAQMFLFLEIHASIRKIAHKEDGSSQEGHHWHAVVVWGLLSSQYFFSTGHQATIPAIRFEAAFVGLPGDMANNILPGLLIFLNTFASSILFAVGLPVLLFWPKISIRLLGKAKKSQEKSATDKGEFVFVDDPIGFREEVFQLITMYQVFHGLKVLFCSCSAALHRRHLMVWKIFAPRFVFEGASYLVTFPFLVFTFLVVLRTDGALEKWTQKLETYFAYKEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3B4</accession>
    <name>A0A6P8J3B4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DELTA-alicitoxin-Pse2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572095.1">
        <property type="nucleotide sequence ID" value="XM_031716235.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306183"/>
    <dbReference type="KEGG" id="aten:116306183"/>
    <dbReference type="InParanoid" id="A0A6P8J3B4"/>
    <dbReference type="OrthoDB" id="5965016at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="2">
        <location>
            <begin position="7"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572095.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="53878" checksum="EFCAE8FBC1E32929" modified="2020-12-02" version="1">MDFNSIKRHLMLLVVMFSIISVHIGIGLGAIPPEAKSHGALGQGFFIPKLNLLTDELHAVGAKIFDTVSADCTVTNDVGRTQKDDTFYSNTESLYKAISTNSKVGVSLKGPXTLGVSLAAVTNNIVSGNTEVSGISLDLKTYSKDHSLKKDCINKQPLDKELLEDFEGLEREIEKPWLSRSWNRYKVFLEKHGSHVVKKVLSGASINQYVFAKSSEKYTQRDFTIKACVSLGGLTNAGXVGVSACSGITNEEAKKASXTSMVKKLVVRGGTPKTRADLTNERNKETISTFLQEGARVPTPITYNFVPIWNILKTRFIGTPSMAKVLNLEQFYKGYLHFGCSFEETSNKQVLQKFVLSEDSDPDVPTYKCMLGPSGCHSDSDCHHKHVFWCACAGESCIRYKDSKLNSGSTKKEAYAYTSRSPGWKGQGCKLRGPKCKCKEPRSIWEESWSGEDENGLRDVHSALAMKRGIVGALTDECNQKQQFKDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3H5</accession>
    <name>A0A6P8J3H5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307966</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574164.1">
        <property type="nucleotide sequence ID" value="XM_031718304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3H5"/>
    <dbReference type="GeneID" id="116307966"/>
    <dbReference type="KEGG" id="aten:116307966"/>
    <dbReference type="InParanoid" id="A0A6P8J3H5"/>
    <dbReference type="OrthoDB" id="5959284at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027640832" evidence="1">
        <location>
            <begin position="28"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="54"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574164.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28961" checksum="2866A8D303835031" modified="2020-12-02" version="1">MSFFSPQNKMRCLFLLVVALCLDDCWGRRLLKNTAFNSSALSRYAKKRTMASTTPKYYGCFEGSRLSFQTTQLNMNNNNDICQEFCKNAGYMFSATHKETCGCFSKHPLNEVSGPQHGADTVRVMNDGKKCNIVCPGKKGVGQCLKEANCCGGDLTYTVYQVGGVNKKRCSTALLEELQKNGVDLAKSTLPTQCPEPASKRTEMSKDCNGIVMDPSTIEKDEKCDENYDTLPKPWACCSPCCDWLVKFLCIDGTVVKCIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4B6</accession>
    <name>A0A6P8J4B6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Guanylate cyclase</fullName>
            <ecNumber evidence="2 11">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116306448</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 11"/>
    <dbReference type="RefSeq" id="XP_031572375.1">
        <property type="nucleotide sequence ID" value="XM_031716515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4B6"/>
    <dbReference type="GeneID" id="116306448"/>
    <dbReference type="KEGG" id="aten:116306448"/>
    <dbReference type="InParanoid" id="A0A6P8J4B6"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027739631" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="526"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="15">
        <location>
            <begin position="864"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031572375.1"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117865" checksum="39F44360B775DA81" modified="2020-12-02" version="1">MAFHYILYFSTVLAIFFVTSKVTSQDEKEIKIGVLLPMVGYWPIGTRTAASVPLAVHDIMQNKSILPGYNISYQIHDSGCNKEKGIRGMVNYQEMDVIIGPACSTAMEPVALLAKIWDKPIITYAASARKFLDKEVFSTTSTVTAYGRRNTYHTTSFVAGLMRAFNWTVCGILSSSEIEWKTLATEIRDAITPAVEIPIFENFYKNLKKETLLTKAKERVRVILLLCYVNDVAEFMYAAKKLGMTDGSYAFVTIDLNTDVFYSNNNWTGNEGPGTQYDQGLDGILDLSVKRPVLTRDFLGRYHGMKSSLPSHIQSQLIDNPSWYAAFLYDALWLAGLALNATISEGFGVKNTSTAVKHLFNLNFPGESGQVVMVNGTRVPSFVVGNFRHGLYVPIINHSIFLTKEDLTSRRLLFDSNIVWPGGTTNIPKSTPGCGFDGELCKENASSHDEHYTLTISLTVFGCCLLLVLILYIRKRQMDKESMFKTWLLNYTDLTPCYDEQDEVGGQKSHIHINQFSTSQTPTLLLRDSDKISTGHPLQPIFTAALYQGKKVYVKRLHHDVLNITRLIKNEIRQACELRHVNINPYLGVCVEPLDLCIVSEYCTKGRLKDILLDEYLKLDWNFKMSFSTDIARGMEELHKSNIGYHGNLKSTNIVVDGYWICKIADFGLRAFKSGNRGTLVKEDTLFSDMLWTAPEQLRNTVDTGHAQSGDVYSYGIILQEIVLREKPYSTSLLGPKEIIHHVKKGLKPHCRPNIPPDSAPGTFRELMTMCWDETPERRPTFSGVLKILKKINKGKATNIVDNMLSMMEKYTNNLESLVKERTRQLETEKAKTDELLYKMMPRSVADQLKTGLQMKAESYEHVTVFFSEILGFAEIAEQSSPIELINLLNDLYSLYDTVISRYHVFKVETMCDSYLVVSGLPERNGKRHAAEIASMALHLLFYFKDFKIQHLTDQSLEFKMGIHTGPCVAGIVGLKTPRYDIFGETVNVAKQLEATGLPQHIHMSEKCKSFLEEIGGFTYEARHNILVKGLGETTTYVLSGKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Y4</accession>
    <name>A0A6P8J4Y4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116308783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575131.1">
        <property type="nucleotide sequence ID" value="XM_031719271.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J4Y4">
        <property type="interactions" value="2517"/>
    </dbReference>
    <dbReference type="GeneID" id="116308783"/>
    <dbReference type="KEGG" id="aten:116308783"/>
    <dbReference type="InParanoid" id="A0A6P8J4Y4"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031575131.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="35341" checksum="E7AF90C5CBA24244" modified="2020-12-02" version="1">MAKCSRYMARVLRVVGFALMVQVVLTCALIPDEREGLLGRFLLASQQKIEEIGQPSANAQSKSFIFPLNDEKSNTEAGKTQSRDQPTDQGGIFSASLGFVHAFIASISVIVVSELGDKTFFIAAIMSMRHSRLVIFXGAMLALGLMTILSAVLGYATTVIPRKITLYISSGLFLFFGLKMLKEGYDMDPNEGQEELEEVQAELKKKDEELSMQETVTQDPETGIIRGGKQHKWYKFISPILVQSFTLTFLAEWGDRSQLATILLGSRENVIGVIIGGTIGHSLCTGLAVVGGRMIAQKISVKTVTILGGVVFLVFAVSAFFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Z0</accession>
    <name>A0A6P8J4Z0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574724.1">
        <property type="nucleotide sequence ID" value="XM_031718864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4Z0"/>
    <dbReference type="GeneID" id="116308445"/>
    <dbReference type="KEGG" id="aten:116308445"/>
    <dbReference type="InParanoid" id="A0A6P8J4Z0"/>
    <dbReference type="OrthoDB" id="5985978at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057873">
        <property type="entry name" value="CTHRC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25815">
        <property type="entry name" value="CTHRC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027952882" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CTHRC1 C-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574724.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20877" checksum="435A4F8DFC17DD2A" modified="2020-12-02" version="1">MRISTIYAILLVFSWTVFGFLPEVGSAPSMRHDTFSQLRKRFSRSVSSNWKECSWNSISEGKDYGLIRDCVFRKKQSNSALHVYWNGEFSVNQCSGCCKRWFFTFNGAECQSPRAIDGLVYLSYGTVWLHRVRHIEGHCNNVQRGNVRVGFNVGDCSGYGNANAYTGWGTASRLFVEEVPSPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J514</accession>
    <name>A0A6P8J514_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572575.1">
        <property type="nucleotide sequence ID" value="XM_031716715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306636"/>
    <dbReference type="KEGG" id="aten:116306636"/>
    <dbReference type="InParanoid" id="A0A6P8J514"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000004">
        <property type="entry name" value="xaa-Pro aminopeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572575.1"/>
        </source>
    </evidence>
    <sequence length="709" mass="80664" checksum="3C33ED2430DF0F2D" modified="2020-12-02" version="1">MLLLTSEQQTFSSVYLQNSKRLILIISTNMKTKNLLFWITVTLPSLVLIGAGAQRRQESVHHFQRRALQEKALPRTNTTKRLADLRALMKAKNISAYIIPSTDAHQSEYISLHDKRRAFISGFTGSSGDAVVTMTHAALWTDGRYYVQAKMEMDSNWVLMKADDLITTEWLTKILKKGETVAIDPYLMSMDSYKSLKTELNKKGLQLKSLLPNLVDEIWTNQPPLPNGTLFPLSLKYTGKTWQEKTREIRLEMKKKKSFALVLYKMDEIAWLLNLRGSDVPYNPVFYSYIIVTLDQVTLFVDKNKITTEVRQHLQMSNCSSLCVLVKNYSQILDDLKNLSSSNDWKVWISPRGSQALAMNVNKTSLYLEYSPVVLPKSIKNDVEIKGMKNANLKDAVAMCELVEWLEKEVPKGRRDLTELMASAKLEEFKSKQEDYVSPSFWSIFGYGPNAAIIHYSPSKSSDRQITTDSTLLVDTGSQYKDGTCDTTRTFHFGTPSLEQKEAYTRVLKGLIQLSLMTWPNKTQGRFLDILARKELWAGGLDYRHGTGHGVGMFLNVHEGPQAISMSCPRSGEHPIVPGMFTSDEPGYYKEGSYGIRLETVFLAVPAKVKSHMPNMYFVTFEAANFMPYERKMILLDLLTDXELEYVNAYHRESRAKVGALLKKQNKMDTYDWLVKRTEPLSRNPVSDGSRDHMATAILLISGLAYLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5X1</accession>
    <name>A0A6P8J5X1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">phytanoyl-CoA dioxygenase</fullName>
            <ecNumber evidence="10">1.14.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phytanic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phytanoyl-CoA alpha-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116308777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.18" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031575124.1">
        <property type="nucleotide sequence ID" value="XM_031719264.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J5X1">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="GeneID" id="116308777"/>
    <dbReference type="KEGG" id="aten:116308777"/>
    <dbReference type="InParanoid" id="A0A6P8J5X1"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000012">
        <property type="entry name" value="Phytanoyl-CoA dioxygenase, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0847">Vitamin C</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031575124.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38792" checksum="25B15A7FC477C9CD" modified="2020-12-02" version="1">MASNKSVGRLARISDHLLQQNTDQTKIYPAPTSYAAPRPYDSHNYVLQNTLLNQEDVDFYNKNGFLVVRNLVXKIHLDKYYERFKDICTGKVRVPGLMVMKDISSKNSEFLPGERSINKIQDYQYDEVLFEYCRLPGILKYVECFTGPDIMAVHTMLINKPPDPGTKTSRHPLHQDLHYFPFRPADRMVCSWTAMEKVTRKNGCLVVIPGTHTNKELLKHRYPEWEGGVNKMYHGIKDFDPNAPMVHLEMDAGDTVFFHPLLIHGSGTNRTKGFRKAISCHYASSHCYYIDVKGTVQEEIAEEVIGVAKRKLGNDVNVTFQDLWKLRQRLVQGNEGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6E8</accession>
    <name>A0A6P8J6E8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116308968</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116308968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575352.1">
        <property type="nucleotide sequence ID" value="XM_031719492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308968"/>
    <dbReference type="KEGG" id="aten:116308968"/>
    <dbReference type="InParanoid" id="A0A6P8J6E8"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="765"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1460"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1491"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1519"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1547"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1069"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1154"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1237"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1354"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1432"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1591"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1634"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1443"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1591"/>
            <end position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031575352.1"/>
        </source>
    </evidence>
    <sequence length="1653" mass="188573" checksum="5D56251E2D7AFC35" modified="2020-12-02" version="1">MIATSARNASHQLDESNMRDMQHTRSSNMSPPRKSPSKQHEVNNEFKSVEQQYSTDSENMIKSEDSGVPSEECVTMSTSPHNDMEDEDTEEMNSSSSQCSCRMWTCSQCNKTFNSARALKIHEVKQHENMPKQYLKCSHCDEVFEHGNLLQIHMKVHHNIKVRCPQCKDVFDHPKALSKHVKAHNTEPVCPVCGLKFDHDKLLKLHMEYYHKVSKRETATLPAEQLEVQTFQPLANLISPDSKRRSESPERRRVNGSSLSPNDIHHREATPSPGREENLREAFHEMKGDDRNSRHTSQSPQEVNISNQEFKRREMISRSQGYDSMYHHRLLAPIHNRGPMYYHSLDDKSRVPSPFGLMPFQPPGLQRRLEKRPLGRSHSLPLKKEAAYHDMPPVAPWQWAEANPMMYGPVPREKRIDRAVLEAVRNNLKAKLRTVEXTLFGEEEDLHHPLSSTLAEYYEQQGPLSSREELSRQYRPSVITPRSTFDSFAAFKRKPSPNDLEPQEKKMFRYEEREVMQDSMESPGLSPSHKASAIPFIPEMRPRFYDPITQSMCGRPFNTRDDSSILRRSDDLNFGDQAKIFIKRGAPRCNRCQQTFSSKMEYLHHLISHREKDGLADESPEEMEFIEGVRRTMNLKSFAMEGRHRTSSNTTPEGSLSPKGEEPRGSQKAGGDDDEADNTEKKAKAKKSPGEQPSPLASQSEEDNLSLGTATCSECKDVFADSMSCRMHIEKRHMKPRCRECGLTFDHKNLLKIHMDCYHSTLDVLQCYYCGMSFKQRSKFLDHLTSHETQDINKDKLGEHGNESTEPGGRRRWGRLVASAQLPSEKPDPGNKERIPSRSDFLETRETSLFKSNGKTKLRKAVSLSTYTDMINRNKRRASDFLRDSRAKGDEVIGRETRTRIFLPNFEDRKIEDVSRFHSAHSTDKELASPLIARQRPSQDDTEQLFLKRRAFQSRNDDEARAFWSAERPPFPAHSLEENQDHIGSYDGKKDELRRLQQQSIPAEGNMRNQHMPLFRKAFVRDEVETLYQLRHKKSLHNPEGKDRDSPPPEPPDHRSDLVKIERIELNPIAMQHKPVERQQPGLRPNYDSERRGEVISSKERCRNVPEQESYSSIVHSGSSPKSYHEEAATSVVPPPPLIDIRSISQTSSPLNVCSAVSADSSPTSSRSNSPLPVTKSHDPKSNKGKFDLEASNSAVVEPIDNSSTMKDVKGKRRNSIKKLTKEALINSLSLKRRASAPDLYQMQRNSTEYPSAEKAESPKTDSTARPGSPSVSSEGRASPVETKHHGSRSQQYTPRKQSDRDVTCTQCGVSFGHKKLYKIHLDSYHGKPQNHECLQCGSKDFRDKDEFLKHLMAHQTKDKRKGDEEEEERKTLVEDGEGFENSRSPGEMRDENLEIAPKAKIPRMDTLYEKNKNMEDVDPYLSEVIVNNASKNENDLNDESGRQSTRVNSNAKDVDDKGTTCLTCGKTFENGKQLEQHFSSHASISEDGRFCCVLCGKAFETHRKLEIHSRSHTGFKPHKCKQCGRCFPYYSSYYYHKMTHTKDRPHKCPLCGKGFIQTRYLRSHLRTHKDEQGTLSDEVDSIIQKVELNLNDETDEESIDSPGTAEGSPAYRANDEEAETAEILCSFKRGLNCSAQNSDTESPPVSNSSVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7D9</accession>
    <name>A0A6P8J7D9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17 18" type="primary">LOC116307620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16 17 18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031573748.1">
        <property type="nucleotide sequence ID" value="XM_031717888.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573749.1">
        <property type="nucleotide sequence ID" value="XM_031717889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573750.1">
        <property type="nucleotide sequence ID" value="XM_031717890.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307620"/>
    <dbReference type="KEGG" id="aten:116307620"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2230.10:FF:000003">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000013">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="14">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="13">
        <location>
            <begin position="289"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="929"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="949"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031573748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031573749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031573750.1"/>
        </source>
    </evidence>
    <sequence length="961" mass="111307" checksum="03706B313CF27A05" modified="2020-12-02" version="1">MAGAARQEEGEENDTNSLSIPDLETQKTEIGELLKKPLKKGDTWYLIDCHWLKQWKKYVGFDSWDVYEVGEEVNNPGPIDNSNLFKDGDENFTLKEHLIDELYYNLVPEEAWNKLLTWYGIGENQPPIPRKVVEYGMYXKXCKVEVYLIEFKLCQNSDMEKVITHQFSKADTLEYIEDVMKEKFEIPKETETRLWNKYXKNTFELLSNKEQTVQDVGLYQGQMLVIEQKNEDGTWQRTNTRSSYSSSTITSSNETSSYGPSSSYGFSSGYWGSSYGSDRKTIHNKPGLTGLANLGNTCFMNSGLQCLSNTMMLTKYFLSDQYKSELNVDNPLGMRGEIAKAFADLLAQLWSGQYSSVVPRNFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRIKKKPYIEIQDANGRPDKVVAQETWYNHRQRNDSIIVDIFHAQFKSTLVCPECDEVSVTFDPFCYLSLPLPMKKERQIEFLFFKDDPVEKPILYKLSFPKMGNISDFLEVVSKETKVQKEKMIMCDVYNHRIHKVFKTRDSITSILDRDEIFVYELPTRIDDPDVIVLPVYQREKRTRVTGYHSSSSAKVLFGYPFFVALPKKSSKYSNLYELALNKIRRFVKSDEAAVENEEKTGEENGDIEMNECKNEEIEDDSDKELEQAYKNVTVNGDDNENDEDNQHSNKKDESQKKQKNDIDEKTKKKSLLFDLTLVNMYGTTDIHALSNDSKPLKLTNQCYVSLDWNSKMKENFYDVSLAEDREEHESVHRKATQKKNTVRLHDCIQLFLNKEKLGEKDPWYCPTCKKHQQATKKLDLWSLPEVLVVHLKRFSYTSFWRDKLDTFVDFPLSGLDLSEFQVCEDAPKPTYDLIAVSNHYGGMGGGHYTAYARNHEDDQWYSYDDSSVTPIGENQIVSKAAYVLFYQRRKMIGSEVKQDERIDDEKMSEQDELEDEKAANGDESMDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J919</accession>
    <name>A0A6P8J919_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Huntingtin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in microtubule-mediated transport or vesicle function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the huntingtin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573400.1">
        <property type="nucleotide sequence ID" value="XM_031717540.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J919">
        <property type="interactions" value="2356"/>
    </dbReference>
    <dbReference type="GeneID" id="116307349"/>
    <dbReference type="KEGG" id="aten:116307349"/>
    <dbReference type="InParanoid" id="A0A6P8J919"/>
    <dbReference type="OrthoDB" id="10065698at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048412">
        <property type="entry name" value="Htt_bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048413">
        <property type="entry name" value="Htt_C-HEAT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048411">
        <property type="entry name" value="Htt_N_HEAT_rpt-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000091">
        <property type="entry name" value="Huntingtin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024613">
        <property type="entry name" value="Huntingtin_N_HEAT_rpt-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20925">
        <property type="entry name" value="Htt_bridge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20927">
        <property type="entry name" value="Htt_C-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12372">
        <property type="entry name" value="Htt_N-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20926">
        <property type="entry name" value="Htt_N-HEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00375">
        <property type="entry name" value="HUNTINGTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031573400.1"/>
        </source>
    </evidence>
    <sequence length="3083" mass="342835" checksum="B9295000986791F2" modified="2020-12-02" version="1">MSLAAADKLLKLFEALKNYRDGIPVPDSNPLAKKKEGLLPKKDRLSHISAIPELLYSSSIRSIQEFPKLLAIGVDTLLASCDDDESDVRLVAGEALNKLLKELLDSNLGRLLVELYKEIKKNDAARSLKAALLRFADIAHLIRPQKCRPFVANLLPCLGRICIRTEESLQEALATAMQKILPVLGSFTSDTEIKQLXKAFIPNLKSAQATTRRTAASSLVIICQNSRKPSMFHEWLINILLGMVLPLQDVKPTPVYLGVLNCIRQLVPHLNESFLSEDIMKGSFGSQRSFIGETGEDHKGVSIKQLLQIYEVVMQCTKHTDHNVVNAALETLNQLLRTPPSPLLKVLLSHDGITPTIKPDTPATEDLEGDHDSAVGDLETASTASTAPTETDLESESNTDFTSTSDYESTKSHEDTASVGTTATDLSSVESTDDLSNRVRELRVARDSSSPDLQSVEDVMESDDNEDKSSILPGPKIGRSLSDPGMVVQEDDSSQAVSETEVDASLQTEIPDDLPIEEQDRICDDLGELNQEVEPLRTESIVTQDVRILVESSFEIDAVACAGVPMVHIVRVMCSFLLSGRPGEVLPDSNVRVSVKSLAMSCIAQAVRHHPEAFLVGVLPDHGESAGQHHRDVQLVRDVLLFNAHPDPQLRGGLGSVLSILIAAGLKKGSLDFNGWSEKCCNEYNTAVLSIESLLSLFGCILQDDSPVAIRQACSALKVCFASLCRSVHCHLVRDLIDILVQLRKKSYWLIKVELLELIEVIDVRLITYLEANKFFQSDSKTDTLLNHLSIQDVLLKDVVFSSLDDDDGRVRHAAAKCCVKLVPKLLLSTGDPRQQAIVQVVSHSVDELKMKNSDNRGSQPSSLHSQATILHSLSKXVAMTTEILNHSTSKYRTIGCIHLLHSLAQAYPIASYPAAWGCSVAVHCSSPISSHFSSTNAPPRPGSPSICCTGGGGPLSLVVGNVTSSWIAYDLIAHQNLLQLSGQLFLGVASSGINVSLKSQISHQTEDSTHAGSSEAWNVFSDTAVGPLAEKLIAHLIRLLNVFAHVIDGATPGAHSFKLSFPGQSKDKSSQPSAPGGASHASPHSSSSTTPTQPVSAVPKRLLKSKRALSEADLPSSDKSPTKAGSGGEGPDGEQKHHQGPPPKSNIGTFYNLPHYMKLYEVIKGTFQNYQVTLSKALQDKFTSFLRCTLSVLSHFLEISSFQEIGKHVEEILGYLLVCVKVEPCKTFLCVQQLLRAMFGINAVSQPDHAHTPVYPGCLGDTLISLPVSMTTEYVDDGGDGLYYDCFELPQREYLQSIEKMVHKEEESESSLKRGIGSFFKKIRRRTGSVIPPAVKIDKQSPIHLFIRLFEPLVIRALKEFTISTSVTLQQQVLSLLAQLVKLRVNYALLDADQIFITYIQKQFEYVDAGQIKNCDTFLPFVFQFLVLLSYECFQPKFNQAKAIVGMPKVIQLCDGIMASGQPAKTHAIPALQPIVHDLFVLRTSGKADAGKEVETQREVVVSMLLRFVQYAEVLEMLTMVLNCYQREDEDRWKKMSRQVIDMLLPMLAKQQIYVENEFGFTALQGVFQAVSPVSLRPADVLLKALFVPIQLTQLLTLERWLSMVLVLLYTIQGHVSEGQLISRMKEIHIKTNILNGLVDETLDEQYQNPGDSVSAEESDKLFSLFLLHVVNIIVQRIANLSNMLAKDNGLDILFLHKQFSSLSLSITHMIKSENFSRITTSTSALCNSQPPHPLVAAINSSLTKILPTHPLLVLRWATVLKSLSFSNPSFWYKLIETGSSAKQETKETRDCVQPINREATRQAAILLYCDLLIEKEADRPGCSLNEVTILLQSCIEDLIRLHAEIPVVKLFSILHKSLDGSRVLMETFISGHALQKERQKRDIPYTKHLVQCLANVHSSQTCLLLKILADFFLDSDCRSITRLVESNICKRLEIEISRLKDPKNETSTEELIAVCHLMASKKQIQRNPRLCSLVHHILASSPRTQTTEQVTSTTHLVTSMKNYVIDQEWFSRLASHCCSTANPDPSVLRARNAQESILLLSALNFSSVCNIMSQEEFDVGLLEDCILVGVERTLQFTSRRLSVEETVIKLYDNTEHFESTGVDHLLLAAKLTIFRHMYHVVQEVVTNVPCEAQEEGNSSSRIIIDKDSFAFLCKDTQWCSRILDLARGIVSYCSVVSSLPRQCVLNADEICCLCRFIFLPLAIVHHKLVSGIPPNTVEMKIALTCIGKLLLLEYDQSVNEVEYVTLVCQAINHVYTLIKAVSVNGTEKLSHEISDEDRRPCADREDEFQSITLACDQISDLVNYTYTYLRPGSQSFSVLPQFLYEPFTLAIVGLARRPLVNSYARTPPLVWKLGWMPTPEGPLKTELPPLPIEILKEKDVLNEFVMRVNILGWINRQQFEETWAALLGVLSSPPLPEQVSQEEDMEASHSCCLAVRCISALLLQTTLYPTPGNCNVGGYLHSPRHRDLPFLGSRAGKKLSVVRGLVEEEFVNNCCTGTGKAYLTKEDVKHEHSASFHRSNSFVSNHGNTAVWTSNKLVFDNPLYGLNVDRILGFHDYTLGQISLLGLHSQAQAQLQEYPDSDDDAAIVVTIPRMAKPEKLDIRSCLQFLLELFEQWMSPYVQPRTPLMLLSEATKALVVFSDLFIDGHHFEWILDTLLELHQNHPSEDDLLIQYSLPVICKALAFLKIEGQTSEKVFKIVETSLRSPHVPLQMSALYGSLYILESHVPTVVSLLIPILTEHLGRKLNTLPNAVMLAQQHLLVMWSTVFYLIEHYNDEIPDAEFKANILKVAVRIASSNEESTPPAVYHAIMRGLERLVVSFALSSSESDSLVKLSVDRLSMQNPQRSILALGLLVTCMYTGKIGDRPSGIYPQPDTTEFPTEDRLLIAMERVTVLFDRIRKGFPSEAQIVARVLPRLLLDFFPAQEIMNKVIGEFLSSQQPYPELMAEVLFKVFEGLHSQGQNVEVRDWVVLSLASFIQRTPLSMAIWSLTCFFISASTNKWIRALFPHILGRINQLEEIDHKYFCAAAIDFYTNQNLDETQKQFFLSTFKSVATPGSAYNQLITSCETQPFLSEMIKIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9Y0</accession>
    <name>A0A6P8J9Y0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308294</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574543.1">
        <property type="nucleotide sequence ID" value="XM_031718683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J9Y0"/>
    <dbReference type="GeneID" id="116308294"/>
    <dbReference type="KEGG" id="aten:116308294"/>
    <dbReference type="InParanoid" id="A0A6P8J9Y0"/>
    <dbReference type="OrthoDB" id="10281998at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027976472" evidence="1">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574543.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17025" checksum="C3F5FBD203886C29" modified="2020-12-02" version="1">MYLKQMIFLGFSDRTFSHRSLIFPLLLFILSGYCSAVPSRTTSSDSRSCYQTGAPEKNVTLMYGLDNPKVEKSLIGHVKTLKECVEIACRRENASLAFTSRFDCYSVTCHGDEELCWLLPSFNNPTLVFARLERKKFNDSKKSKETKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JD81</accession>
    <name>A0A6P8JD81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116309109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116309109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575533.1">
        <property type="nucleotide sequence ID" value="XM_031719673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116309109"/>
    <dbReference type="KEGG" id="aten:116309109"/>
    <dbReference type="InParanoid" id="A0A6P8JD81"/>
    <dbReference type="OrthoDB" id="5983188at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575533.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35001" checksum="42DF1810E2C34809" modified="2020-12-02" version="1">MKEDCFLMKADRQLSRASDISRAXSFVLMIMEDFDTDSLSSGKKVRFNSNDEIFVIPNKWDRLSRKTVAGKEKLQRESRTTSKPKAVDAERRGKSKQRSKKVKRSTKSIYTKTSTTKTLASPSSQVMELESSVLSTEISKTTRERSKISSLEKDSKKTETPEVKLKLSHRNNKELSQDDIVLPRINYNSNLRKSIENAVVRNRPSFETGLARLHEQSRDNLGFSSLRTRSYSDTNSSTNSSILSEDQDNITYQEECLFVLPESETAKFSELSRYVEGWSPFSXGHSTENRLTSRQKMPGSIPNSILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GWK8</accession>
    <name>A0A6P8GWK8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TNFAIP3-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548639.1">
        <property type="nucleotide sequence ID" value="XM_031692779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GWK8"/>
    <dbReference type="GeneID" id="116286307"/>
    <dbReference type="KEGG" id="aten:116286307"/>
    <dbReference type="InParanoid" id="A0A6P8GWK8"/>
    <dbReference type="OrthoDB" id="5969558at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882:SF11">
        <property type="entry name" value="HDA1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031548639.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35714" checksum="4F2C997CF99357CD" modified="2020-12-02" version="1">MADGSSVRNLEGGNDSSASSISSKSTISTFNEREFILKLLSEKRTLLAALHSEKKDKLKWKSEYEKLFEERSTLDRSVQDDLTDPTGCSMRLGTLTLGEEGAAYQNESKILHNRVREQERTIQSLRSQNASLLNQVAVLRSEVIRLAGSLSKLDVQVDTELLKEQLSLYEEDFQKEKDDKVNAQSKISTLNEQLRDCQDLISSLTVELDMYKTAYEREKKEKEKMLLKSLQRDTQRTTVSSENKRQNRPQPLPKPQLQVVYPVVNTQAHEDDTRRRQQLQRVGVFTRDMQRSPNYDLYGNDGDPEPHWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GXI1</accession>
    <name>A0A6P8GXI1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116286566</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548984.1">
        <property type="nucleotide sequence ID" value="XM_031693124.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116286566"/>
    <dbReference type="InParanoid" id="A0A6P8GXI1"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="13">
        <location>
            <begin position="147"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="12">
        <location>
            <begin position="333"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="14">
        <location>
            <begin position="469"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="825"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="870"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="16">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031548984.1"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111666" checksum="2318D8D5F3743C17" modified="2020-12-02" version="1">MSTSSPRVTITNLTPLGNYQVRVVGSDEKKAYGSEAFDFVTNRIFTTPKPEETESPSPTPTESIKLMYDYGPPEGDNVVLLTSRYSGRCLPIALNDNGILVFEKRHYKLFICMNGLIRFGAPWYIHWPHTLGSSHQSYDKDLAMLAPYWSLVDIYSFNLGISNIYYQVYDSSVNTLKTRNVLARATFDVNRLNPQPLRTKFQASWVLVVTWSRLRHANRNSQTRVLYNTFQAVIITNGVYTFAMYNYPPNGIQWSAPTASVNYNRFWNSRGLPVVGFSAGNRFSYIIPRSGTVNVESIDSNTGQKISFNRNILQNHPHDIVGKWFFRLETSTGTAXAEQKCREWFKKQPDPRPFLEYLEPCPCTSRQAWWDERFIPEAXWWRKSLPCAYSTFASVDGWEQKCCYSSNWGALIVGFPGGGTPHRYNRMQYGDHFESDVRSYEWCCVQSALCHLYYEKRPSGDCSQYEPPAWSWIWGDPHFVSLDGRNYTFNGLGEYVMMDAKDGFFQVQARTRLAKGDGTATVFCAVVARERNTSKVQMELENEGNITLLVDGEAYDYYSLTNQSLRMNGSVVISRPNDNAFRATFPSGISXTVTEIKGALSILLAMPKSFRNHTKGLLGTWNGDQTDDLTTPSGLVLPANASSKDIXFQFGQKWQVNDSTSLFTYDAGENVSTFSNTSFVPMFIEDLKFYNESLKQQAYAACNGDINCLFDTASTKDLSVGISTKIVGSQMVNESSTLKNSPPAFQNGSSLDIYAKVNRTELVTFQAKDPNGDAMEFIVTGLPDKGIVKXSNSSVTIVWNVTTKAVQLEVIVKDSKGANSVLRPMLHVCACHNGGDCLTSNQEENRNNSRFSIMSCHCRSGFTGRFCESDIDACEXNMXPCYPGVQCKDLPAPANVTGYECGPCPPGFTGKGESCSDIDECDGSTHGCSQVCANTPGSFACDCNHGYLLNIDGRSCDDVNECDPASDCMQGCVNTPGSYRCTCDKYFTVDPTNPKRCIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYK6</accession>
    <name>A0A6P8GYK6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgi-associated plant pathogenesis-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549294.1">
        <property type="nucleotide sequence ID" value="XM_031693434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GYK6"/>
    <dbReference type="GeneID" id="116286845"/>
    <dbReference type="KEGG" id="aten:116286845"/>
    <dbReference type="InParanoid" id="A0A6P8GYK6"/>
    <dbReference type="OrthoDB" id="5973011at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028064125" evidence="1">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="34"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549294.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23756" checksum="C29950114C2A5502" modified="2020-12-02" version="1">MSTSRTMVLFMYIFWAVISLEANYVNGQQTASKTFKQYCVDTHNSYRSKHKVPNIKWSDTLEKEAKSWAQYLSESNNLFRGSKGENLYLSTKVQPYTASSCETAVNEFYTGESKYSYDRALLSRASERFTQLVWKNTLEIGAAGLQRKDNKTVVVVRYNPPGNYNTTVAFKSNVFPASSKQTSSSQSDASHVQIQIPLTLVAVLAAMHILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ73</accession>
    <name>A0A6P8GZ73_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide FF receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116287047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549519.1">
        <property type="nucleotide sequence ID" value="XM_031693659.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8GZ73">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="GeneID" id="116287047"/>
    <dbReference type="KEGG" id="aten:116287047"/>
    <dbReference type="InParanoid" id="A0A6P8GZ73"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031549519.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="37639" checksum="67559EAA811BADB6" modified="2020-12-02" version="1">HVAIGVIGTFGNILVFKVILSQRKRKVSEYLILNLCVTDLGACVVSVPLDLVELALRRFPFGKFMCSVAYPFQTVLMAVSVMTLLEMSYERYRLIVTPFKRRINSKIAICTIIVTWGISSLLILPYMMVLRLENNQCIEKWPLEFYRKVYTVSVFLVLYIIPLLIITISYTLVIRNLNQDSRKQIMECFESTCNRSAHMRSXMISXVQRNMKVVKIFMSAGVXFAVCMLPTHLCWLWHDFGSGYTNKHFTKLVTFSNVLMYLNSAIDPFIFGSLKVRQLCLDITCCRVCREKRHRGNLFRLRTTTKQNLLHTTEQEVIHDRVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ86</accession>
    <name>A0A6P8GZ86_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Cytochrome c oxidase subunit 5A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Cytochrome c oxidase polypeptide Va</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116286447</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548823.1">
        <property type="nucleotide sequence ID" value="XM_031692963.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8GZ86">
        <property type="interactions" value="1059"/>
    </dbReference>
    <dbReference type="GeneID" id="116286447"/>
    <dbReference type="KEGG" id="aten:116286447"/>
    <dbReference type="InParanoid" id="A0A6P8GZ86"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000002">
        <property type="entry name" value="cytochrome c oxidase subunit 5A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031548823.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15445" checksum="99570F574007AD81" modified="2020-12-02" version="1">MLRVVSRRLLXPGFSRAVPALGITARQSSNKPKESEEAFDARWEAYFSRPDIDSWELRRGLNELYGHDLVPEPKIINAMLHACRRLNDYGMSVRILESIKDKAAGNKEIYSYIVKECKPVIDELGISTPEELGISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H259</accession>
    <name>A0A6P8H259_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287019</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549486.1">
        <property type="nucleotide sequence ID" value="XM_031693626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H259"/>
    <dbReference type="GeneID" id="116287019"/>
    <dbReference type="KEGG" id="aten:116287019"/>
    <dbReference type="InParanoid" id="A0A6P8H259"/>
    <dbReference type="OrthoDB" id="5999311at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028343017" evidence="1">
        <location>
            <begin position="20"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549486.1"/>
        </source>
    </evidence>
    <sequence length="774" mass="86324" checksum="D99E598EBFF003D6" modified="2020-12-02" version="1">MISTQVLTLFLVIIVPCASQHAPGFGCNDTFLMVELHKCEKTMLQALIDDPSANCREEVKKLQQCSRKLIVDRCYSSLYALYPKLREAVEKMMDVTLKQVNKASFYCSDHKMKINWEMIPNAVKKVLPCDKRFFEESLQCAEKFRAAFNKNKKDPDLCRLYTETKRCSHRISYIYCTSSSILSVNKLNPFCEGGRDIEEPSNDMTIKKKPLKCMVHVCSNSSSSLFPTPPCAPPQEITCATPKGLPFEYDACMTSRITLEPVEGVTVTQVNRNCSSSFLCKYDVFCSTANSTGAIQSCNVNCCKGELCNKDNSYQTKIQPTESEVSSFKCISSACTKSSSPLFPPQCGPEQEITCNSPRTSVPLYDRCITSRVSMGSIAGITVEQEIRNCSYSLLCESELFCKAVNKSGLVTRCDIQCCEGNLCNRKRPIKTTPIPQTATPKVFSPLTKTAIPTKPPKRKPLKCMVYSCSNSSSSLFAAPSCAPPRELTCATPEGLPFEYDACITTRVVTKPIAGLIVEQEMRNCSSSFQCQQPKLFCDMVNTTGLLKKCDVHCCKEDLCNKKETKATLAPQSVTQRVSSPPTKLPKEYRPKFQKGVWTKVTPSWISGHLLHGVRVKYRRVNNALVIEGHVTSYGCHRRPGSGLTTFIRGNWTRILYTQEFMGSASCWRIFGSSGRKGGYKQVERSGLEEFDTTKGDIIFNELKMGGKDRDAFNGITYMCGQPAKNFWHAQNGQALRRATVMLRRKTDGSKAGIHTATSCGQPSFIVKDIFVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2G2</accession>
    <name>A0A6P8H2G2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tctex1 domain-containing protein 1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550589.1">
        <property type="nucleotide sequence ID" value="XM_031694729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288013"/>
    <dbReference type="KEGG" id="aten:116288013"/>
    <dbReference type="InParanoid" id="A0A6P8H2G2"/>
    <dbReference type="OrthoDB" id="10248487at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550589.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19857" checksum="404103B1C7EA496F" modified="2020-12-02" version="1">MSVRKLLRHLSERRPKMSRGRTQSWPYDSKLTKNRVEYLGTIHEKNFDTSPRNTNDSQRLTCANKVQDDEFCSIIQDLLKSYLEQFESYDHNLCSRLGSMLSDLIRAKVYETCGDNWKIISNVYIGAVRDQGIAVASQCTWIPECDKFATASFENEALFAXGVVFAIYILGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2M6</accession>
    <name>A0A6P8H2M6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116287321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549848.1">
        <property type="nucleotide sequence ID" value="XM_031693988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2M6"/>
    <dbReference type="FunCoup" id="A0A6P8H2M6">
        <property type="interactions" value="1747"/>
    </dbReference>
    <dbReference type="GeneID" id="116287321"/>
    <dbReference type="KEGG" id="aten:116287321"/>
    <dbReference type="InParanoid" id="A0A6P8H2M6"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000001">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="13">
        <location>
            <begin position="293"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="468"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031549848.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="60572" checksum="00EFDA7B13A64880" modified="2020-12-02" version="1">MQSDVPKRLKQPVVLSVVPDFKRYPDRLQMYRLPPTDNISLEEFEEFAVERLKVLREIETNSIRYKKDSDEYKKNTMKALKELVGVNYKATGEENIKKKSNEIHNERRKDHISHFILRLAYCRSEELRRWFLTQETELFRFRFDFEIDPKAIDSFLEHNNLSYTDISKEEKDRLEIKLKDSGYNLPLQLVQATQYYKVPFTEALDLVRSRKVYLEGGYAYVPRNELSSIISNVFRTNLSHALALTARALPYLEEDERLLPRLTNLSRQYVGQDYSQKKNIAGGKISLDQIDAVAWKSFPLCMRNLHQSLREHHHLKHGGRMQYGLFLKGIGISLEESLIFWRSEFSKVMELDKFDKQYAYNIRHNYGKEGKRADYTPYSCMKIIMSSQPGPGDCHGCPYRHTEPNLLKQRLATHKLGKEGLDQVMNLVKESHYQLACTRYFELTHSTEDMPGFNHPNQYFEESRKILTGNTSSSQDRRSQTPRPIKKENAIKQENTKENELLEELDDSELMEVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H807</accession>
    <name>A0A6P8H807_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288906</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551631.1">
        <property type="nucleotide sequence ID" value="XM_031695771.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116288906"/>
    <dbReference type="InParanoid" id="A0A6P8H807"/>
    <dbReference type="OrthoDB" id="5988035at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551631.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39677" checksum="33126139BF19E9C2" modified="2020-12-02" version="1">MADEESVVLIDEKLAETVRGFPILFDKSLKDFKDRNKKDLAWSDVATSVGFASGKDAENAFKNLRNRYTRDKKKLQCVKVSGTDTKTVNEVKSETSDMFPYLAWLDEYIKPRRSSSNMVASMSEDGSNIDEEEASDDKTDPSLDSDCSEPTVIKSKTTGRTKNIKRSKRDDFESAGIELIKSIGSKLDQRKEPEKDKDEETIFSELIGTQLKKMPLHDRLMAKMEINQTMYKFMMKNTSDYSYPNFESPVATMPNQFARPFPPNQLCQPVTGMATSDNHPSXVTSPLGTFRMTSTPETRFQKPTRVMTPPINEIQNVFSRETSDSETNFELYPRGYFFEELRRDKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H831</accession>
    <name>A0A6P8H831_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: kyphoscoliosis peptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551403.1">
        <property type="nucleotide sequence ID" value="XM_031695543.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H831">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="GeneID" id="116288715"/>
    <dbReference type="KEGG" id="aten:116288715"/>
    <dbReference type="InParanoid" id="A0A6P8H831"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551403.1"/>
        </source>
    </evidence>
    <sequence length="812" mass="91626" checksum="9A4C8DBEE7F691C1" modified="2020-12-02" version="1">MGCGPSKKDTRGIHEVNEITKKPKSKTTTNDDNNNFTKKQFKVGERVHVRGYVGTVRFVGSTELGDGVWIGIELDKLHHQGNDGYFKEAKYFSCKPKHGLFVRPESVELHTEELPDLSPETVVKIQTQVRKILAKIRLRNLLKRSENEKLIDKHVMNTPPKAEKGINELSEYLTKPFESDRDKAFAIYRWLCFNISYDVEGFFGRRSKASCDAEDVLANKTSVCAGYANLYEALARASGLEIHFVSGYAKGYGYKAGQRVDGANHAWNALKIDGQWYLSDATWGSGSLGDDLLFQRAPNTYRFLMQPDYAIYDHFPEDEKWQLLDKPVPRETFEKAAVISGPLYEMGVELLTHNETHYSIDSDSIEMDFYCPGRKILLMAKLKDSSGKAHDGQKSNCRQRIQLRRCGLNQVRLHAQFPIKGDYSIDIXYVNVEGTWTFGLTYYITANKGCGKNTGGFPRISNSFYDDGFDLVTPFTNIETTNGRAEIQFQCYNRRYWSLNGNLSGTDGSSQKKILKNQALSISEKTNDGFILKVDTPAPGTYCLRIFAKCVEEGDSSPFVCEYYINNLETTKRPLAGFPNLSDHLYSWGLELVEPRENILTKDGKATIKIKATELCNLDISSIRLLGNVHRQDGANMNLLTNQELYFTETTSNSLEMKVDTPGAGTYLLNIFGTSEKGTNVFFCSYFIHSSEKEKRAAVGFPLASDVFHKLGMKLVKPRENIYSTDGRAEISFECPEKLTEVKEYIQKEKETIHGCCKTTTATDENRTIKNISVQLPSKGLYKLNVFGKIDDGNASDFLFSFVIFAEKGVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8X4</accession>
    <name>A0A6P8H8X4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC116286490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17 18 19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031548875.1">
        <property type="nucleotide sequence ID" value="XM_031693015.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031548876.1">
        <property type="nucleotide sequence ID" value="XM_031693016.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031548877.1">
        <property type="nucleotide sequence ID" value="XM_031693017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8X4"/>
    <dbReference type="GeneID" id="116286490"/>
    <dbReference type="KEGG" id="aten:116286490"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="90"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="15">
        <location>
            <begin position="561"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031548875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031548876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031548877.1"/>
        </source>
    </evidence>
    <sequence length="687" mass="76976" checksum="CA656BCCB1ED4411" modified="2020-12-02" version="1">MSDNAAEQALQYLRDPAVVVGLGAAAVSLAYMATRPEPTPCPVNVKQQSIELSNDNFARRSALTADLVEYLFEDCRTTHEVFLRGASISGDKPCLGQRSSPDGPFEWLSYDEVLERSSCTGSGLLELGCKNVEDDITYIGVYASNKIEWVLVEQACAMYSMVIIPLYDTLGPDSCVYIINQAKMTTVVCDPVKIPLLLERCDKCPTLKNIVKLKGEIKDEDREKAEKCGIKIIEYDDLEKMGKENKHEKKLPGAKDLAVVCYTSGTTGNPKGAMISHGNIISMLSGLVILIQKCGIQVDNNDVHISYLPLAHMYERLAQLLCFMFGGRVGFFGGNIRKIMEDLQELKPTLFISVPRVLNRVYDKVIKEVSGSTVKKFIFNTALSFKKAELERNIIRRNSIWDYLVFKKIQNSLGGRVRFVISGSAPLRDDVMVFLRCALGCIVLEGYGQTETTAASTIQLVGDNTFGHVGPPMPCNKIKLVDVPEMNYFAKDGKGEICFYGYNVFQGYLHEPEKTKEAVDEDGWLHSGDVGEWTENGTLKIIDRKKHIFKLSQGEYIAPEKIEAVYMQCPLVNQVFVYGNSHESCIVCLVVPDEAQIKKWAAKNGCDGDVENLCKNEKVRTAIFNEMIAMGKKEKLYSFQQVKAIYLHPDPFSVDNGLLTPTLKFKRPDITKHFKDTFEEMYRKLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H981</accession>
    <name>A0A6P8H981_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289336 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552086.1">
        <property type="nucleotide sequence ID" value="XM_031696226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H981"/>
    <dbReference type="GeneID" id="116289336"/>
    <dbReference type="KEGG" id="aten:116289336"/>
    <dbReference type="InParanoid" id="A0A6P8H981"/>
    <dbReference type="OrthoDB" id="5977621at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552086.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17895" checksum="F0D0943E788335B0" modified="2020-12-02" version="1">MIDNFCCEICRCSCGKCSTAFLQNANEFYCCKDMEKCSGALSDEWVLEEMQTPPNCITLHPAFQTVCLDRWSLRLSAGKYRTIDGRSYRQTGSEEKFMRSVAYREFIHLVYDRVGKNKIPLPTCAYHAIRSKFQPKDSDECFVEFEDEVEEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9R0</accession>
    <name>A0A6P8H9R0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116290315</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031553174.1">
        <property type="nucleotide sequence ID" value="XM_031697314.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290315"/>
    <dbReference type="KEGG" id="aten:116290315"/>
    <dbReference type="InParanoid" id="A0A6P8H9R0"/>
    <dbReference type="OrthoDB" id="5960381at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553174.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51631" checksum="2B5EEB7F5E36B2DF" modified="2020-12-02" version="1">MSHYNCCVPGCTNSFRSASHLHYYRIPKDEAVRKSYKVILKNDSLKLNSTSTXICSEHFEGGAKLSRTHLPSIFPWTKPEIKRRELKRVSFDKIKEIEEEKRQRRLLKENSILAIETQTNTTSQTSLTSLDIEPLLKDLQRHKEDIVKLTEEKEKLQNENVKLSDENTTLLQANCKLEQEVKRLRYSLQNIRFDVEKYKDKNEDIAFYTGFPDYKAMLLCFKMVEDSANNIVYEHERVSCGNVGRPRCLTKFQEFTLVLMRLRLGLFEKDLAHRFNVSRSTVSKVTNAWIRFLRSEFEPLITIPPRDVIKMYMPDILKSFYPDCVVIVDCTEFEMEKPSSLNCQSACYSSYXSRTTMKALLGITPSGALCFVSELFPGSTSDEEITAQSGFLGKLLPHDKVMADKGFNCTDELASVGAELIRPAFLDKKKQFSKEETNHNKTVASLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBA7</accession>
    <name>A0A6P8HBA7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5-hydroxytryptamine receptor 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549962.1">
        <property type="nucleotide sequence ID" value="XM_031694102.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HBA7">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="GeneID" id="116287421"/>
    <dbReference type="KEGG" id="aten:116287421"/>
    <dbReference type="InParanoid" id="A0A6P8HBA7"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031549962.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38386" checksum="559189C25C5D2450" modified="2020-12-02" version="1">MDTLLNETLFQENQQQCYYLDILPSIVRSNSIYFLEVFLCFVNGISSIIAVSANLIIIIVICKNPALHSNSNFLLCCLAFPDALVGFVVQPSYIASKIGELLNIFSLQCEARMLMESTGLISAGASLCTLAAITLDMFLALYLHLRYKDLVTKRRLLALVILAWIVVSVAALLRLXLDNTIIGIAVVLGLTFNLIIIIVSYNKILKVVRRHSKQIYGTGQTSTLSTNKRGREVLKHKKFVYTMMYVVVIVMLSYIPLGGVVFVYIYKGNYRNLQLAFDITVSLMLLTSSINPVYYFFRITEVRKAVLKTLKKTRIEDASLGNISRRGTNWVQSEIRQTTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBJ9</accession>
    <name>A0A6P8HBJ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116290843</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553814.1">
        <property type="nucleotide sequence ID" value="XM_031697954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290843"/>
    <dbReference type="KEGG" id="aten:116290843"/>
    <dbReference type="InParanoid" id="A0A6P8HBJ9"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.50">
        <property type="entry name" value="chitin-binding protein cbp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027748438" evidence="8">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="9">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553814.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="31750" checksum="39D6E82893812F1F" modified="2020-12-02" version="1">MVRELSCVALLLAILFPLVAGHGFIRDPPARQVCYREFPKRCTAVHWTPDELNCGGFSTQWHKNGGKCGVCGDAYHLKNPAFVYPGRFAKGVITKVYRQGQEFDLTLTITTNHKGWSEFRIGDIGTPPITQAKLTHLLQLSSXGTRWIHGSKSGTYTIKLRLPAGVTCKHCVLQWWWKVGNSWGCEGGKCGQGLGQQETFVNCADISITTSGGTLPTDGPIPPTQAPTPPPPFPTTQTPPRPTDPPTAPPTQAPPPPGGKCKAIGAWEGNPGMDAWCNSNCAFNNCPSNICLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCT2</accession>
    <name>A0A6P8HCT2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium/myo-inositol cotransporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Sodium/myo-inositol transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 5 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116290042</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Interacts with KCNQ2 (via the pore module). Interacts with KCNQ1; this interaction is direct. Forms coregulatory complexes with ion channels KCNQ2-KCNQ3 and KCNQ1-KCNE2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552878.1">
        <property type="nucleotide sequence ID" value="XM_031697018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCT2"/>
    <dbReference type="FunCoup" id="A0A6P8HCT2">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="GeneID" id="116290042"/>
    <dbReference type="KEGG" id="aten:116290042"/>
    <dbReference type="InParanoid" id="A0A6P8HCT2"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000013">
        <property type="entry name" value="sodium/myo-inositol cotransporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF150">
        <property type="entry name" value="SODIUM_MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="45"/>
            <end position="65"/>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="96"/>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="129"/>
            <end position="154"/>
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    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="194"/>
            <end position="217"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031552878.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="76659" checksum="079A5373455505A1" modified="2020-12-02" version="1">MVTYHPPGLEGWDIVVVVLYFVVILGVGFFAMFKSNRSTVSGYFLAGRFMTWLPVGASLFASNIGSEHFIGLAGSGAAAGIGVGAFEFNALILLQFLGWVFIPVYIAGGVCTLPEYLHRRYGGQRIRIWLSVLSLLLYIFTKISVNLFSGALFIRLALGWNLYLAILLLLFMTFLCTVTGGLAAVIYTDTLCTFLMSVGSLTVMGMGFAEIGGYSGLKEKYMLAVSNDTLYSNSTCGRPRPDSFTMLREPLHSDMPWAGFIFGQTIASIWYWCADQVIVQRALAAKSLSHAQGGCLLAGYIKILPLFTLVMPGMISRVLSPDRVACSVPEKCMEICGSEVGCTNIAYPELVLKLMPTGLRGLMMAVMMAALMSDLTSIFNSASTLFTIDVYGLFRKKASVRELMIVGRVMVAIMTIIGILWIPVVQNVQGGQLFIYIQAVSAHFSPPIACLYLISIFWTKATEKGAFWGMMMGFVIGVIRMVLDFTYQAPKCGESDQRPAITKDLHYMYFALVLFWITGIAIVVISLFTKPSEGANTSRLTWWTRYDSPAESKYSGETGKGKEVLLDDINKSVKLTKMTYRDENNDAEKENKEEKGEKEDSLIDQEKALGSDERKSDIVIIDAKRSPIRRFYNWFCGYETGSEEAVKAAIEQEQRISIVTSLEQDPRAKIFLQVNVAIILCIGLALYIYFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCX0</accession>
    <name>A0A6P8HCX0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 11">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116290066</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 11"/>
    <dbReference type="RefSeq" id="XP_031552908.1">
        <property type="nucleotide sequence ID" value="XM_031697048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCX0"/>
    <dbReference type="FunCoup" id="A0A6P8HCX0">
        <property type="interactions" value="2549"/>
    </dbReference>
    <dbReference type="GeneID" id="116290066"/>
    <dbReference type="KEGG" id="aten:116290066"/>
    <dbReference type="InParanoid" id="A0A6P8HCX0"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048776">
        <property type="entry name" value="HAT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21183">
        <property type="entry name" value="HAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="16">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="196"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyltransferase type B catalytic subunit C-terminal" evidence="17">
        <location>
            <begin position="288"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="14">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031552908.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="49182" checksum="84005869996C0D4A" modified="2020-12-02" version="1">MMIDRRLSWSKRGKRYAKMEVEIRAAEDFLSSFKTSANSAINLKLVTTENDIFDKGKEFHPEFTHQLFGDNETIFGYSGLQVQLYYHSGSLLTYLGMTYDSDVNGKLEGIEAEPVLSTIAEQLPPGFCTNLDDFIAKLPSEGKFRPMGELLYSYRHNEKDYEVYYADIKVPKFKEYHSRLQTFLLWYIDAASFIETDDERWNFYLLFEKKKVSGETEYSIVGYMTVYHYYAYPDKLRPRISQMLVLPPFQKQGHGAKLLNTVEEHYIKDPRVLDITVEDPSDYFIRLRDYVDALACSKLQCFSPDLLKKGFTADLASEAQKARKMNKLQCRRVYEILRLKATDRSNAEEYQNYRLDVKRRLNAPYQKEKADADKLKKVLSAEEMSATLLLPSPSEQRKHLEQLYEELEECYLRTIERIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDZ0</accession>
    <name>A0A6P8HDZ0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116288230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031550857.1">
        <property type="nucleotide sequence ID" value="XM_031694997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDZ0"/>
    <dbReference type="FunCoup" id="A0A6P8HDZ0">
        <property type="interactions" value="1234"/>
    </dbReference>
    <dbReference type="GeneID" id="116288230"/>
    <dbReference type="KEGG" id="aten:116288230"/>
    <dbReference type="InParanoid" id="A0A6P8HDZ0"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031550857.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="39861" checksum="F04C46BF343AFFB5" modified="2020-12-02" version="1">MADTAGKPIKCRAAVAWEAGKPLTVETIEVAPPKANEVRIKILATGVCHTDAYTLSGVDPEGLFPCILGHEGGGIVESVGKGVTKVKPGDHVIPTYIPQCGECKFCKSPKTNLCGKIRGTQGKGVMPEGTSRFTCNGKTVYHFMGTSTFSEYTVVADISCAKVNEKAPLNKVCLLGCGISTGYGAALNTAKVEPGSTCAVWGLGAVGLATVMGCKVAGATRIIGVDINPTKFMLAKQFGATECLNPKDYDKPTQEVLVEMTDGGLDYTFECIGNVNTMRQALEACHKGWGTSVIIGVAAGGKEISTRPFQLVTGRVWKGTAFGGYKSGDGVPKLVDDYLAGTLKVDEFITHNMPLDKINEAFDLMHKGESIRSIVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFE3</accession>
    <name>A0A6P8HFE3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Prolyl endopeptidase FAP-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116288625</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551305.1">
        <property type="nucleotide sequence ID" value="XM_031695445.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HFE3">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="GeneID" id="116288625"/>
    <dbReference type="KEGG" id="aten:116288625"/>
    <dbReference type="InParanoid" id="A0A6P8HFE3"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="15">
        <location>
            <begin position="155"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="14">
        <location>
            <begin position="621"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031551305.1"/>
        </source>
    </evidence>
    <sequence length="821" mass="93888" checksum="DACAFF3F8EFB1B67" modified="2020-12-02" version="1">MEEGNRHLLDPAPDKQRYSAMEVQDPESSLGSKLVDSDDNHSSMKINKRALVVFFGVTTLAAAVIVVAVVVSLYSVGEKSSSTRLKRDTSKFTLDDMLQGTYNPKHYEVEWLNDDEYMTRGEGGSVDIVNPTLNISSTLVKKENAKNFGIPIVISPDKKFIFYPRNKTQQYRYSSFADYYVYDVENNKEEKIQTNGNTKIQYVSWAPNVDPNSLVYVSNNDMYYIANVQVPLPASVRLTNTGKEHVIFNGVPDWVYQEEVLNAEYALYFSKNGKFLTYIEFDDTNVKDFVFPWYGSSSNEYTKQHKIAYPKPGTSNPLIKVKVIDLSKPSKAIEVPKPXSIRKGDHYVVQIGWLKDSLFSVQWLTRDQNYSITNLCQLVDDPSRDNIDCNKNKGHVEKVNNGWVDDQYMSPILGDNYYIVRYPFKQGDDGDYLHIAKVDIGSGEITPITSGKWEVTNVYAFDDQRELLFFESTRESPVTRHIYSVSIKDNVITCLSCNLPEVKRGESSYFRASFSKKGSWYVLDSQGPSVPWTRLYSSKDPTKVVLLENNQELKEKLKKLPMGKTKIIKVPSDNNEIYTKIFYPPFFDERKKYAVMFYVYGGPSTQSVSDAWSLGFEAGYLSHNFDMICVYVDARGTMGRGQRFKHAVFHHLGRYEATDTINVAKYMRNLPYVDKDKIAIWGWSYGGYLTSYVLGQDTGVFKLGMAVAPVADWRYYDSIYTERYMGLPQYNKEGYEESSVLPLAKNFKNVHYLLVHGTADDNVHFQNSAQLVKKLTEEEIEFQVQFYTDKNHALAGDGTSEHLYHLLTRFLKEKGIAFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFZ1</accession>
    <name>A0A6P8HFZ1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116290910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031553888.1">
        <property type="nucleotide sequence ID" value="XM_031698028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFZ1"/>
    <dbReference type="GeneID" id="116290910"/>
    <dbReference type="KEGG" id="aten:116290910"/>
    <dbReference type="InParanoid" id="A0A6P8HFZ1"/>
    <dbReference type="OrthoDB" id="10016527at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06607">
        <property type="entry name" value="STKc_TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000030">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031553888.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42603" checksum="4B4CB31F5B5DB833" modified="2020-12-02" version="1">MPSVKVALFKNPEYAGLFDEHDPEKLYADLREIGHGSFGAVYYGRNVKTQEVVAIKRMSYSGKQSQEKWNDIVKEVKFLKQCNHRNTISYLACHLKDHTAWLVMEYCLGSASDILEVHKKPLKELEIAAICADAIEGLKYLHSHERIHRDVKAGNILLTEDGTVKLADFGSASLASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITSIELAERKPPLFNMNAMSALYHIAQNDPPTLTTSGWSEDFVHFVQSCLQKHPLDRPSSEQLAEHRFITGRRSNGIIKDLIHRTKAAVRALDKMNYHRMKKMIMSDVPGEINAEGTSDSDSISPYQDTDDKDPQVRVNHLHSGLQFCYKHHRKACMLTRLGLYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG33</accession>
    <name>A0A6P8HG33_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clathrin heavy chain linker domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554786.1">
        <property type="nucleotide sequence ID" value="XM_031698926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HG33"/>
    <dbReference type="FunCoup" id="A0A6P8HG33">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="GeneID" id="116291716"/>
    <dbReference type="KEGG" id="aten:116291716"/>
    <dbReference type="InParanoid" id="A0A6P8HG33"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012331">
        <property type="entry name" value="Clathrin_H-chain_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032755">
        <property type="entry name" value="TSNAXIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF11">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN LINKER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15739">
        <property type="entry name" value="TSNAXIP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translin-associated factor X-interacting protein 1 N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554786.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="69064" checksum="8EE6461817AE19CF" modified="2020-12-02" version="1">MDSIRMPSHERTRSMDSITRFSTRKKIRIQQTVPSSDVSDIEKYIEDELRRLNFHPDTTRHDNYIVHKHAFDQLVDSKAVVYKPILSKIKAEFEDCIEALEKGKSQSVYLQGMVKALMVEKSTLRHFIRRGDELEEKVEKLRNFNSSLRGRIHAYQSERARRIASAEAKSLGAVKKHIKKTIPGLSLEELTDIPTLKRTLAKLDSQVIELQNASGTKFVERDRKMALKNKITQKEEYLVGLNDVNAKLKERCDVLKVVVEASKKALKNPDKDVHLYSVAVKALSEYGKTKYGKQSNALQQFLTFDDDDPIKKKEAERLIDYCDHFNNLFDFGQYEAAAIHAANSPFGILRNYETLIRFKQADTVEGGQTPLLTFCDALMATASAAQPLTQAMSVECIRCALSENRLDLATHWLAQGKLSYSIPLGEVLAEHCNCPKTCTCTCLPLAQTVFMQVNAHSRAAKCLCKQGKYITLLHYTKKHGNFESEDYKNLLKSNPSTELAQLMLTTKGHKKNSHVLSFAAVVSALLDKENHSQLVAVLKRLSSYDRLSLSSIVNRILYEADDNEMNADKWLEVVSICEEAGLYEVGVEILAAITIGEALNRASIAFSMDYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG67</accession>
    <name>A0A6P8HG67_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-3' exoribonuclease 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555399.1">
        <property type="nucleotide sequence ID" value="XM_031699539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HG67"/>
    <dbReference type="GeneID" id="116292262"/>
    <dbReference type="KEGG" id="aten:116292262"/>
    <dbReference type="InParanoid" id="A0A6P8HG67"/>
    <dbReference type="OrthoDB" id="6012758at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028265302" evidence="2">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555399.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="38720" checksum="FA63AC9213C70B09" modified="2020-12-02" version="1">MRTTALWVVFTLFVVLYQVSAHPLASHKLAEEKDKENIEKQEDKDVKQEEKEESEDSEEKKQDEVSEDEDNESSAEEEKGEDEEEEKEEVDSDNSDNEASGSASDEKKERNRRSDEDSGEEPEEGSAAPEKRSKAVAVKKRCGGFGGCGGFGGIGEFGDGFGLGGGGCGGGCGGCGGGCGGGDCGCCEWGKPGAGCGCSNCCGGFGCPHSCGGCGCGCCPNLNFPCTFGACVNNPCCECCSKKPPKGKCQWPCYWPCCCKCTPPKFEFKPLKAKPLCHCPHCSTSPCGGCMGCGHKKDGKPKPGKRDTIQKRCGCGGFGGYGGYGGYGGFGGYGGYGGYGGYGFGGTFFPGLAHGWSSLPGYGYGYGLPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGU4</accession>
    <name>A0A6P8HGU4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555071.1">
        <property type="nucleotide sequence ID" value="XM_031699211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGU4"/>
    <dbReference type="FunCoup" id="A0A6P8HGU4">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="GeneID" id="116291977"/>
    <dbReference type="KEGG" id="aten:116291977"/>
    <dbReference type="InParanoid" id="A0A6P8HGU4"/>
    <dbReference type="OrthoDB" id="8951197at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555071.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="42600" checksum="7CD85646134E8C11" modified="2020-12-02" version="1">MNGTERNDTSTNPTDRYSLVVGTTILTIDLVFALVGVLGNILVCVVITRRANMKTSMNLYLRNLAITDLGVLLVNFPLSIYSIRSPSKGWVLGRFLCLYISPGLDVFFGASIWSITVIAIERYKNIISRKVFVKKGESFKRVTLKIVLIWLVSFAVVAAPLYPLFVYKRANNSAYYDCYPIWPAFMNNFMFKAYAVSLAIFWYLLPLGIITVTYWKISAQLRQSNTFHKTMHGEEAAKSKLFKEEERRRLKQNKKAQRILTPLVVIFAVTMLPLNMLRLLIAFMPEFNLLEKNYYVLIHDLSVLLIVINSSLDPCVYYLCSKEFRVGMKALFSKKGNFLESRDTMMQTTSNSHKTTTRSLLTAEVGTLAAESSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGW2</accession>
    <name>A0A6P8HGW2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551795.1">
        <property type="nucleotide sequence ID" value="XM_031695935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289048"/>
    <dbReference type="KEGG" id="aten:116289048"/>
    <dbReference type="InParanoid" id="A0A6P8HGW2"/>
    <dbReference type="OrthoDB" id="5965432at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551795.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39141" checksum="7FBB7649F0BFD8BE" modified="2020-12-02" version="1">MGGFISTIRDIKVILRDLKITLKFTAKIVLKXHGIVDDIENTVQELKTTVNNLSARVPAQTATIQEQLMEEKSATYLNEVVQCIETTADSVKTSLANAISVLTSDDLLKNTSDAFDNLVSNHSGTNLSGVMARWASIPDGIGDLVRQDCISLNDYTQSSNGVKSLKAKTSDKTDDNQLTELAKSSAKMNELDSKDDMSRPISGNDELDNKMEKIPRRNVKEISFIEHSGTGIVRILKPLLNINNHSFSASKWHEIEIFSTLANRTNRNCRSEQQDKSIVKPQDMIQTKLLSGRDCLLEPMTELQTDILSLLLMTLVQGFSSENTKVSQKAITILSGGQKCKSVGQALMAECMTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHP9</accession>
    <name>A0A6P8HHP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555366.1">
        <property type="nucleotide sequence ID" value="XM_031699506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHP9"/>
    <dbReference type="GeneID" id="116292226"/>
    <dbReference type="KEGG" id="aten:116292226"/>
    <dbReference type="InParanoid" id="A0A6P8HHP9"/>
    <dbReference type="OrthoDB" id="5989102at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46670">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46670:SF3">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555366.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19862" checksum="E29F603FD55DA566" modified="2020-12-02" version="1">MQQFFCKAKSTTKTVSYRKLKSIDLEALKDYLRASKLIVQTPSQLNDLVSSYNKTLSSLLDKHAPLLIRSVVIRHRVPWLTDEIRAIKRQRRRAERKWRRTKLDTDQAAFKALKNRTTYVMNSVRREFYTDFVNDNSDDQRKLFSATKKLLGQQYEMQFPLHSDVSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI54</accession>
    <name>A0A6P8HI54_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556059.1">
        <property type="nucleotide sequence ID" value="XM_031700199.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HI54">
        <property type="interactions" value="1915"/>
    </dbReference>
    <dbReference type="GeneID" id="116292842"/>
    <dbReference type="KEGG" id="aten:116292842"/>
    <dbReference type="InParanoid" id="A0A6P8HI54"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="73"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="241"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556059.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39750" checksum="57E33A5542625423" modified="2020-12-02" version="1">MGDDVNEEPEHFNPHEDREKRKQVRYEYRELISETEKNSLEFIKPESKGLHKALDRAEELFDEVKQTREAVLDSHFLVLASKLGRQQAQKLQTHLVKFDPDVFAEKLITFMGGRSLTQVANQDDDEEEDDDAVGTSRPNKRRLLQLDWNRLGKKAAPYLKRTPSLTFMFGPLAIGPPVRKTRAPSANKPKDKPNAAEKVTPKQLDKVESQEEATTGEVSRVYKCLAKATAPRGPDEEFQPVGLFEFIVNPESFSQTIENMFHLSFLIKDGRAKIDIDEDTGLPYVEPFEPYNEGQCKETVLRKQVITHLSLPEFKEIVQVFXIKKSMIPTRAAMTDXQSGLTNGFHGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ90</accession>
    <name>A0A6P8HJ90_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bardet-Biedl syndrome 4 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116289863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552660.1">
        <property type="nucleotide sequence ID" value="XM_031696800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ90"/>
    <dbReference type="FunCoup" id="A0A6P8HJ90">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="GeneID" id="116289863"/>
    <dbReference type="KEGG" id="aten:116289863"/>
    <dbReference type="InParanoid" id="A0A6P8HJ90"/>
    <dbReference type="OrthoDB" id="309339at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000237">
        <property type="entry name" value="Bardet-Biedl syndrome 4 (Human)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031552660.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="58805" checksum="8245A5BBE65EE51C" modified="2020-12-02" version="1">MASTSSLQSEGSHSVRSPTGTDSPSVAGSSPDGSVTSVKSPTSPKPLNGAAVPDAPSKQPPAKRSEAPKRRGKVPDLPVFERRNWLIHMHYVRKEFDKCKVLIKEQLFETQYMCEYALYAQALILRQEGKIQESLDLFQQTVKINPFNADNLKQVARSLFLLARHKAALEVYNEAAKLSSKDWEIYHNQGVCYLYLKDFEKAKDCLKHAIQYHRHDASFLQLGKIYLMEGDIESAIDTYKKAIEFSPENPDLMTTLGLLYLQIGMTQRAFEYLGNAMTYDPSHVKAILGAGSMIQTHGDFDVALTKYRIAASKIPESPHMWNNIGMCFFGKKKYVAAISCLKRAAYMAPFEWIIIYNLGLIHLTMQQYASAFHFLSAAITLKPKHGQLFQLLAIALTHLDDHDNAKQAYEQAIMLDIDDPAISLNYAIFLYNMEDRKQASRHFAAYEKKMEVFRKTKGGDIEREILETGNRLGPALQVGEKLVWDAEAKTTRIPSSKAQNDKNNSSPATSASSSAATLPEDGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKS9</accession>
    <name>A0A6P8HKS9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556989.1">
        <property type="nucleotide sequence ID" value="XM_031701129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKS9"/>
    <dbReference type="FunCoup" id="A0A6P8HKS9">
        <property type="interactions" value="1389"/>
    </dbReference>
    <dbReference type="GeneID" id="116293667"/>
    <dbReference type="KEGG" id="aten:116293667"/>
    <dbReference type="InParanoid" id="A0A6P8HKS9"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000025">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="408"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556989.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="84665" checksum="9F20FE9E728DB409" modified="2020-12-02" version="1">MATEPSVSTSHIDHLLAEVESSDGLLGPTLRAVYDGQHQKEFMEKLEERIKVHDKDIERMCNYHYQGFIESVNELLKVRGEARKLKIKVQDANEVLQDSGSELVKRCEELIQCRTVQRNISSAIEKLSLCLPVLEMHAKLNDQMKNRRYYPALKTLEQLEHTYLPRIKKFRFADIMKDSIPRFREKIKEESMFDLRDFLENIRKDSEKLGSIAMKQAFHRSNLTLSHGVGTRKKGDDEELDQSALDLVDFSPVYRCLHIYTVVGEREYFEHYYRKQRRKQARLVLQPNHGTIDESLAAYRAYFHQIVGFFVVEDTILHTTKGLVTRSTVDDLWDMAASKIAAVMRTQSTYCKETSLLLQVKELIVWFCYTLSGYGLNVNQIYDVLIEMRNLYNETLMKEWEGVLKGAVPSILNFSECPVKLYKEFKEFINACLKFNEHLNVSQTEIGDSVRKSTNLLLTRTLNGCITSVIKRKDVSIPQLAQLSVNTVHLEAACLHLEEYVAEVTGTANDGVNVARVYGLSTFKDIRAELEQQMYEKLNMKIEEFIQLANYNWVPSGPRKQPSSYIVDLLAYLHSTFLNFSVLPGNVVQTACLSSCKHLAGSMRTLLLDDEVTQMNEHGINCFNQDLRQCEEFANSSPVEGISDGTLQMTFLELRQLVDLLLSFDWSTYLKDHGSTTSKYNRVNPQIAAKLLEKLMESEKKRGFSLKKTDRDKKKLNETIIKKLRSLNGDNTGNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL06</accession>
    <name>A0A6P8HL06_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Golgin subfamily B member 1-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Golgin subfamily B member 1-like isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Golgin subfamily B member 1-like isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC116293757</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIMBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557077.1">
        <property type="nucleotide sequence ID" value="XM_031701217.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557078.1">
        <property type="nucleotide sequence ID" value="XM_031701218.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557079.1">
        <property type="nucleotide sequence ID" value="XM_031701219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293757"/>
    <dbReference type="KEGG" id="aten:116293757"/>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000023">
        <property type="entry name" value="RIMS-binding protein 2 isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554257.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="61608" checksum="4A451C5DE395C71B" modified="2020-12-02" version="1">MSRRSPESFTLARMAAKLSEELGEQVTCPICLEHYSDPRLLPCLHTYCRQCLQDLLAKGDRKDAVVCPECREEVQIISGDVTKLRVNFWINNLLSLLAIHSTDEKDGGKTELTCENCDMKEKGTRRCANCCMFLCDFCSTAHQRSLATKDHQLMTLDEIKNTGIPVIEKQLFCGKHKGEIKKLFCNTCQELICRDCTIIDHRDHQFSFVEDVADQHKQLFKTEVERASVTKKKIEXVLKSVQTMKEKVEKTSKATEKDVDDFIDQQIKALEEKRIVLKQETKKIVATKMKELAAQEDGLTMHLTGLKSAIYFTEKVVKSGGNSDILSVSKEVTSRLSQLCERQFNENPRQQYTMGLQSDEQIFREWKDQHVSVVDACIPDPKQCLVTQSINGRFVPNQGPIKATQGQILKFVICVSNVFGDKLRFMEDRIEVMVFHSPNQTSGFQFGSGTGGLFGAMSNPSSTPSFCTTGSARSGSNNITTQIRDIQCHEDNTYSFDFCFDRGMSQAEINVKVDGIQIQGCPFRITYGTGPGVGLGFGPTKMAGSTYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HP81</accession>
    <name>A0A6P8HP81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116291433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554465.1">
        <property type="nucleotide sequence ID" value="XM_031698605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HP81"/>
    <dbReference type="GeneID" id="116291433"/>
    <dbReference type="KEGG" id="aten:116291433"/>
    <dbReference type="InParanoid" id="A0A6P8HP81"/>
    <dbReference type="OrthoDB" id="5976606at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="70"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554465.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45663" checksum="FB8FAB7F3F553232" modified="2020-12-02" version="1">MAKNKIQKYLEKLYYDPKQPGSFTAPESFYRAVREKSGDKISRKQVYDWLASQETYTLHRRTRKKFKRNRIIVGRVDEQWQADLIDIQKIKKYNGGNRYILVAIDVLSKFAWREPLKAKTGECIVQGFEKIFKKGRKPEKLQTDHGKEFLNKRFQNFLAKNDIHFFTTASDTKAAIAERTIQTMKAKLYKYFTHKNTLKYTDVLQQLFDSYNDSYHTSIKTKPSMVTQENEEHIWHILYDKDLIDGPIKFEFHVGDKVRLSKLKGTFEKGLFRKALPFLASASKQAGKVALKTGANVLADAAAGQRFQDSLRNRLKESGMELKRDVTTQVKNAMNGQTGSGKKRKRGQQERSGVPQKKRKQTKAKPKRIKRKTKSKSLTTSKATKPRTFQDIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPU7</accession>
    <name>A0A6P8HPU7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1B-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557108.1">
        <property type="nucleotide sequence ID" value="XM_031701248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPU7"/>
    <dbReference type="FunCoup" id="A0A6P8HPU7">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="GeneID" id="116293780"/>
    <dbReference type="KEGG" id="aten:116293780"/>
    <dbReference type="InParanoid" id="A0A6P8HPU7"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557108.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40875" checksum="A461D8B3DB2A45B1" modified="2020-12-02" version="1">MFNTEIYKKQMAARSPALVALETIVMVTITVTALLGNLMVCWAVYRSKKLRTVPNLYIIALAIFDILMAILCMPLSVEVFITANFAHGENAVQFQGFFSFFLSLASLQTMTAMAINRFYRIVKPVLFRKYLQSLQSTVLSLVMIVVLATFGACLPLIFGFAKYTFHYGKVFSYIDYSTPLAAYIYTIFLKICYITIPTLITLFCYYRIFATVKNHTKELMANQRNNSGSTGGGLSMNVEDVNITKALFATVLGFVACWTPVAVVDMIDTFSNHALNNPREVYLFYIYMGYGSSSINPFIYGILNRSFKREFIKIFRLHFSKRFSNETELSNSANKVAPMLLLFVRPANANDFVRNNSDANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ29</accession>
    <name>A0A6P8HQ29_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="3">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116291681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031554742.1">
        <property type="nucleotide sequence ID" value="XM_031698882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ29"/>
    <dbReference type="GeneID" id="116291681"/>
    <dbReference type="KEGG" id="aten:116291681"/>
    <dbReference type="InParanoid" id="A0A6P8HQ29"/>
    <dbReference type="OrthoDB" id="5986275at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554742.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14029" checksum="65DC658BDAD62703" modified="2020-12-02" version="1">MEELKSNGKKQIIAATNALSMGVNFPDIRYVVNWGPARNILDHHQEAGRAGRHNVTSDVVIIFHGQQLSQCEDDVKSFLRASGCLRVASYKAFDESIKPLEQGHDCCTNCRESCLCQGDTCCIQTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQF9</accession>
    <name>A0A6P8HQF9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554872.1">
        <property type="nucleotide sequence ID" value="XM_031699012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQF9"/>
    <dbReference type="FunCoup" id="A0A6P8HQF9">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="GeneID" id="116291801"/>
    <dbReference type="KEGG" id="aten:116291801"/>
    <dbReference type="InParanoid" id="A0A6P8HQF9"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027783663" evidence="7">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554872.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="55120" checksum="6FBD4E84D849F54A" modified="2020-12-02" version="1">MFQLFSTFLFFVLFVAPSESASKPHILFILADDFGWSDVGFHGSKIQTPNIDKLASEGVILNNYYVQPICTPTRGSLLSGLYPIHLGLQHGIVHNGCPYGLPLNLTLLPQKLQQSGYSTHMLGKWHLGFYNWESTPTYRGFDTFYGFYSGAENHYTHIQGHYLDLRDNKNIVDDMNGTYSVHLFTKQAEKIVHLHEPSQPMFMYLAFQNVHSPVQAPQAYIDRYSFIDDPLRRTYAGMVTIMDEAIGNLTNAFKNAGLWDNTLLVFSTDNGGVPKNGGYDYPLRGRKDTLWEGGIRGVSFVHGSPLARRGVKCNGLMHVSDWYPTLVNLAGGSYDKETLDGYDVWDSISLGKPSPRTELLHNIDPLQESDKDDVGFGYQGIGLRVGDMKLLMGVPNISYFIPPEDRPIDYMETTQENKVSIDYVAVALYNVTADPYEKNDLKDKYPDIVKQLQDRVEFYKKTAVPPANKPNDPQAKETAKKNGAWSPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQN6</accession>
    <name>A0A6P8HQN6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanylate cyclase soluble subunit beta-1</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Guanylate cyclase soluble subunit beta-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Soluble guanylate cyclase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116291878</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031554967.1">
        <property type="nucleotide sequence ID" value="XM_031699107.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HQN6">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="GeneID" id="116291878"/>
    <dbReference type="KEGG" id="aten:116291878"/>
    <dbReference type="InParanoid" id="A0A6P8HQN6"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000094">
        <property type="entry name" value="Guanylate cyclase soluble subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000001">
        <property type="entry name" value="Guanylate cyclase soluble subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF2">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="494"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031554967.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="83219" checksum="D0CF058C3E9D23B2" modified="2020-12-02" version="1">MRGGMKTWRTRKKPRVRNRTKSQPTNSAHIQRLGFKPLTSXRGQVAVPSRASISTSSKSFKMYGFVNHALELLVVRNFGEDKWKEIKRKAELNIEGHFLLRIVYEDELTYGLVGAASEILGIEPSAILEKFGEMFFDFCQESGYDRILQVLGGTLRDFICNLDALHDHLAAIYPGMRAPSFRVSDRESDGALILHYYSERDGLEPIVVGIVKTVARKLLDTEISVEIFKRKEHDGDHVQFVIKEIDQRGSQCPLQVKPFDPIRDSFHLSNEPKISPATFCNSFPFHLMFDRDLRITQAGSSVIRIVVGLNADNEANMTEIFELFRPQMAFNFDTILAHINTVFVLKTREGKIIPPEDSKLEQGEMKTCSVCGDALSLRLKGQMIYIAESESMLFLCSPSVGDLDDLRDLGLYLSDIPLHDATKDLILLSEQFKAEYVLTQQLEILTDKLQQTHKALEEKKQLTDQLLYSVLPPSVANELRHKRPVNAEKVEMVTLLFSGIVDFATVCKNSEPMEIVLLLSNIYSNFDRLTDPEINDVYKVETVGDKYMAVSGLPEKCNWHARSVCNMALDMLFVVQDMKHKGEKLEIRIGIHSGEVVAGVVGHKTPRYCLFGNTVNLTSRTETTGAPNKVNITEFTYRCLQEPVNNDPSFVFEKRGPVHXKGRTEPMITFFLSRDPKFLSESYINRLNGKNSPQWCGNSNGISPAPEPLPQQPQGVPAMCPFSNLQTPKRSKIVTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQS4</accession>
    <name>A0A6P8HQS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein CG3556-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557458.1">
        <property type="nucleotide sequence ID" value="XM_031701598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQS4"/>
    <dbReference type="GeneID" id="116294067"/>
    <dbReference type="KEGG" id="aten:116294067"/>
    <dbReference type="InParanoid" id="A0A6P8HQS4"/>
    <dbReference type="OrthoDB" id="6343110at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027954">
        <property type="entry name" value="Transcobalamin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14478">
        <property type="entry name" value="DUF4430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027939620" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Transcobalamin-like C-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557458.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15099" checksum="AF97F06ADDBF71DB" modified="2020-12-02" version="1">MNTYVAVLLVGSFCLLQAAVVKINVCVRLEFLTTNSNNELPKAPPPLTLKVRNGTNTHNILRQAAKLDSRYAFTTKAYSFGNMVTSISGVHQDHTNSKYWMIYSDPNTLTPTGIDHYRPKDGSCVIFKYEKLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS66</accession>
    <name>A0A6P8HS66_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558311.1">
        <property type="nucleotide sequence ID" value="XM_031702451.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HS66">
        <property type="interactions" value="2418"/>
    </dbReference>
    <dbReference type="GeneID" id="116294792"/>
    <dbReference type="KEGG" id="aten:116294792"/>
    <dbReference type="InParanoid" id="A0A6P8HS66"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08688">
        <property type="entry name" value="C2_KIAA0528-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037785">
        <property type="entry name" value="C2_C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056430">
        <property type="entry name" value="C2CD5_YbjQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23028">
        <property type="entry name" value="YbjQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558311.1"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117542" checksum="B050AFE91B9B0F53" modified="2020-12-02" version="1">MPGKVKVRIVSARDLPVMDRTSDLADAFVEVRLGNMMYKTDVCKKTLNPQWDSEWFRFEVDDEELQDEPLQIRIMDYDTVTAHDAIGKVNISLSSLLTQDPPGSISGWFPIYDTMHGIRGELLVMVKLDFFVDSNKFRHTSCGVQFFYTCCIPYGFKATAIQGFVEELVVNDDPEYQWIDKIRTPRSSNEARQRIFTKLSGELQRKIGLKVLELGGNAVVGYRQCFDLEGEYGIVVRGIGTAVTLAWLPSSAPSTPRLLSSSVELISAGPIGETGFTFPEVVRTNVARARQHKSSSESEPELTNTPPKDGLTVQCVLASGLEGSGASSGCTTPYSIAKGVWQITTQKQKNIEHMDLPFFTITRFPPKFLRHLGGVVSARSVKLLDKINHXDEPETRDAWWLEVRTEIRSHARSMGCNAVVGYYESTSICEELIVLSATGTAACIDSNLFELPSATAGLLATKPIIGLPSSTQTPTDVDQALTVQTNYESPVTEGISPVEDLTSTSPPPTGCSLCHIPYSDTDLPFPITLAKCHVCRFHKVPDLLFCTIDPPIETSITGKGCLIQARVCRTKKKEKGETNAEIVSNILPFLEYELHQQLMNKLKVKGMNALFGIHLQICVGETMIIGIASATAVFLSALPPPPLLKISGKRTSTDEDKRLTEIQKQIIETTNKNRLRFKISESLELTPPPSPSQIEAMNSGEHEEEGRASLDFVTGGKDAFVVEVDDKKDEDIITVLLDPPTPEGFYCCNTETLPGVTRVQSGVKMITAVQRHEISDEDIRTNQQFAKMFDDTMKSFWFKLRHFNPCSLTNVRFDVEIPEDDNIQFAVSGVVVGMEENVEERKEIRRETLVKDRNSASKKTSSEDLLFPIEEFEDTKSQPRKTSPASKQPVLALENKLTIPKVPPAHRPAVEVTPMSYLPNAQIERYLGNVNLFFIRESLSIREDGGLNVFMQVFLAEAQAILRAHVQALGGNALVSYQLNEIVLLDNPHKHQGQCLLNVSGDAVEVFYDEESKLADSFGRTSPRKCRTTSVTESIPHSPIKLHRQRSATEGYCAGNITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT04</accession>
    <name>A0A6P8HT04_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Substance-P receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116295749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559519.1">
        <property type="nucleotide sequence ID" value="XM_031703659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT04"/>
    <dbReference type="FunCoup" id="A0A6P8HT04">
        <property type="interactions" value="2156"/>
    </dbReference>
    <dbReference type="GeneID" id="116295749"/>
    <dbReference type="KEGG" id="aten:116295749"/>
    <dbReference type="InParanoid" id="A0A6P8HT04"/>
    <dbReference type="OrthoDB" id="5952899at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559519.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44330" checksum="D8922076746B6A80" modified="2020-12-02" version="1">MNGTFNSTLTNLTNDWIPTTEEGSETSQKAAGSSAMNSLRTASYCVLILLSLAGNSFVIATVVRNTNKRMRTVSNIFIVNLSIADILVTLINMPGKISQIYIGRMWLLGKSTGFEILCKMMNFLPFLAVFVSTQSFAVLALDRFVAVYLPVRKPITAKVAYILVAFNWIFAMAFFYVYFHSASIWTHGDTSYCYVNANVVFGSMENFNKFVWVEFTVVTILPLTISFVLYTATMIKLWKRKIPGSNATANASYSDRVNRRVLKMLITVFLAFFFCWLPTWIWIIACKRTGKSSNLPALCSAKSQFSMTRFLIAYSNSAITPYIYLIFSENYRQGFKDILIAMACCSSVRKVLRRRNRVEVFTLSQFTQGDRLRTNTVSRRMERLDFTTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT89</accession>
    <name>A0A6P8HT89_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein kinase 40</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116295808</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031559609.1">
        <property type="nucleotide sequence ID" value="XM_031703749.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HT89">
        <property type="interactions" value="1437"/>
    </dbReference>
    <dbReference type="GeneID" id="116295808"/>
    <dbReference type="KEGG" id="aten:116295808"/>
    <dbReference type="InParanoid" id="A0A6P8HT89"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13974">
        <property type="entry name" value="STKc_SHIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024236">
        <property type="entry name" value="Ser/Thr_kinase_40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="45"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031559609.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49886" checksum="799728A3150AA723" modified="2020-12-02" version="1">MRSSNSGAIGAKRKANCLEEDEGASTSKRSKKRSGPSGLRRAGPYLLGPRLGNSPVRSIVQCLAKKEGTDDFYSIKILTLGEVGHETQDDKQGKMLLHTEYSLLSLLHDEEGVVHHHGLFKDEYMEEGASESDSHNRNSSDKPGTSSKSRTGKKRYRLCLVLDCLCAHDFGTGTADLINLQHYVIREKRLNEREALIIFHDIVRVVECLHKKNIVHRDLKLGNIVLNRRTKKIRITNFCLGKHLIRENDLLKDQRGSPAYISPDVLSGAPYSGKASDMWALGVVLYTMLYGQFPFYDSVPHELFRKIKSAEFIIPGESLVSESTKSLIRLLLTLDPNKRLCATEVLGFLXNTMTTWYHLASNGETPQVVPDLEDSTESNSQEKDKNIPPELDLRFHKLSDEFYKQEPLVGITQEVVLQPPIRRITEDARPLTAAEILAHRHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTR5</accession>
    <name>A0A6P8HTR5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295968</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559789.1">
        <property type="nucleotide sequence ID" value="XM_031703929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295968"/>
    <dbReference type="KEGG" id="aten:116295968"/>
    <dbReference type="InParanoid" id="A0A6P8HTR5"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36649">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36649:SF28">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028264765" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559789.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29447" checksum="0427986E91DC46F6" modified="2020-12-02" version="1">MAALIXAVPVVGFVAAATAXAFKAIGGRKRTECYAIAAAAFSAIFGVRIICEEEAKIEIEKGNPDVKRLEIKDLFKLKPRNFDGQSPSLYYIPDSAYDPQYDYDFTNHSSFLERCTRGGYPYKRPAGWKRKAVRVIGKYKDDVWLGQQGWRSESSSGEWPVSFHGTRIENVQNIVTEGYDIEKFVRHKYGRGIYSTPYFEVAERYAIKFNYKGEDYKCMLQNRVNLEETETVETLDGPYFITPNAXNIRPYGLCIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUP6</accession>
    <name>A0A6P8HUP6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hamartin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556332.1">
        <property type="nucleotide sequence ID" value="XM_031700472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUP6"/>
    <dbReference type="FunCoup" id="A0A6P8HUP6">
        <property type="interactions" value="1956"/>
    </dbReference>
    <dbReference type="GeneID" id="116293075"/>
    <dbReference type="KEGG" id="aten:116293075"/>
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    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="797"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556332.1"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121117" checksum="8D4D9C97D217518A" modified="2020-12-02" version="1">MSSSGPSSTSSGSESTSDRPTELIALLDSENAETVEQTKAIIHENLYKSRDTSLLNALVDCYLETRSPTALQILTNVHEARTHNLFEKLNDCLRHCGLRGRIDTMTLLGHIVRKQPSWLYKIVKTPLFETVIKSMKSESDVLYLMNGALTITTLLPIIASYVESWLNDVFDVYTRLAGFLNSRPGNIPDIYMLHLHVSVYFYFHRIYAMYPNNFVMFLRGYCHNNARKQIVFQTIIKPMLEHVRLHPCLITETSQSETGKHRWRKKEPQDIVIECENMSLDPLDRLQTDSSLTTSWTSLHDALGNTQDKSVNSVLTTSEDLNKEVCDVPIIKERRMSDSATQTGKSLQSGDSGTGSIPLVSSEDFNSAWSPTEMCGLSTPPSSHMSPATSSQDLVAVQANLSISQCSTPGFASTPGDSPTSSLAGDLAQSSPALLKNRKTLAKTLSGKSTPSKTVGLDSPLIHRALNSMSIQTKAETSTPKTETLVTDSSHVLSSPEVESSKFNYERQTSELSVQSEPITPIDKSLTYDYIRNVKPEHEMQEQLTCSDHSETMDNATKEIKRILSQNDFASLQNAESPVNPPPSLDASLVSNSNFSSNGILSQGLQHINLSNDKFTIGMSDDVEKIMKDVSKHALEEPNLMPYKSESKNTLVSHSSEISEGSRTRLVTPTPQDDHQNSYNSETLAMLLNQKGQYPGARHEQDDDYKRCLSPRPTPIELLDNYIQVGSGVQLNELSRISLVSSPETDWTHFGGEAPVDEITILRGQIQLLHFQLLYERHKCYQHAIRNRRLIGKTFKAVQYEEELLAIKDHLRLQEEKMRELTESLIKQTEDNSKFKEITSGWDNQQQTQLRNLLNENAKLQHDKKMLNDTLENQKKEHDSLQMKLHQCESKIFTLQNEIDCMKPKLAEKSQLKSEIERLIKELVIMGELNQHHKDMMEKAAVDKGKKPEASLQFYACQKELTASKQMVRKQKTEIEALHSKVAELEKHLTKKDVEMKEFRKFSESLNGIYLAKHKALEEKYTAQKKINQTLEARILNLQLALEDTKHENTMQAAAKTKTRATRATSPIQEETSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV00</accession>
    <name>A0A6P8HV00_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116293167</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116293167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031556422.1">
        <property type="nucleotide sequence ID" value="XM_031700562.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116293167"/>
    <dbReference type="InParanoid" id="A0A6P8HV00"/>
    <dbReference type="OrthoDB" id="100767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="5">
        <location>
            <begin position="293"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="7">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="7">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031556422.1"/>
        </source>
    </evidence>
    <sequence length="1273" mass="144913" checksum="086DAF5C85DD4D4B" modified="2020-12-02" version="1">MEESLPEDNHSVVRKRICDKLKGMCEDLDEKGKLEKYGPKMEKICKEMDADAGKKKDTDADPHPGEETADVITLDDKGGYYDFSSDFFFLEVPRNAVNTPVKVKYKVDPCRCQPPMAGITTSYSYFLELTSSKTVELNEPITVTLMHSGPGKEYGYKTTVIAFNQDGNVWEELRGEEEGFDKTTGKMTAVDVVPXTFDSLLGNISKFVXAEAAFIIHQLQRLYPSRKDSFDNNDLYSAFKQLYKLGAIDKDGDQKMMEILVKKTAKKDEILKXINDYKQESTLPRKDDSVGREAVXKEIRDSLTSEDAVSAVNLYGESGVGKTTLAKVVSGLMEDFDMLWIDLRDIINVETVYFFVLYGLGLTSWDREAKRIYDHLENISGKTLFVLDNIEQFFENEEGQILMEFLSRIINSLASYEGKLKIILTSKDSVFEQSLKEESSTTDYKVKEFDEKSAKDLMTKRIKNVVDVADEAHDKALSEIADLCRNLPYLLQGAEQLMRESFTTPKEVLRKITTQLEEALFDLKQSLAIHRKVYGDHTLTXRTLNLIGNCYMECGKPKEALTFYQRAMDMKIKLVGGEKHFDIPTYYNQLSQVYETLGKGEIKTSSEIFWSFQNFANSIWDSISQKKRHDLEKATEFLEKALSLQKKLGVNDTDDTATFQRNLANILIGLQDYDRALEYGQKSLKIRNKSLGKHPETVRILYLIGIIHEWRNDHKAALASYEEAFVMEESLPEDNHSVVRKLLCDRLEAMCKKLNKKDKLEEYRPRMEKFQKETDADAGKKPDADADVADADAETGEGTDVITLDDKGGYYDFSSDFFFLEVPRNAVNTPIKVKYKVDPCRCQPPMAEIATDVSYFLEMSSSRPVKLNKPMSVTLMHSGPGKEYGYKTTVLAFSQGKYVWEEPELVEEEAKGSPACKTDFIRVQISKLCTLAVVTRLITDRFQVTHKGCVVRSSVCGDVTIEFPQGAVAKTVEGTMKLMLMPENKDACSILCMDGFSSIAFLKSVIVKMPLPNNTAEYSTKDIRLLRLDDNRWEDNEWEDVTDQAKIVKLRTHMEFRVRNFSCWWPWISKEKIQSASKIFRTLCFGRHVCFAAFKDTDDDAPLLPKLTLVCAENHMEDKILSKMKGQGYSKLAITTSDQKMTPNDKAYPKVNGADMRIERFFLSFLRGQVCRKELTVRDTRQDQENHEELVIRFFPNPEENLDHLLLGILQMSKDKVFSRSGGGNQRTPLAKDIPSPPIWSTKVASNLNLELSNEQKRWIVVGIGLNKTLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVH2</accession>
    <name>A0A6P8HVH2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">LOC116295631</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031559371.1">
        <property type="nucleotide sequence ID" value="XM_031703511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVH2"/>
    <dbReference type="FunCoup" id="A0A6P8HVH2">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="GeneID" id="116295631"/>
    <dbReference type="KEGG" id="aten:116295631"/>
    <dbReference type="InParanoid" id="A0A6P8HVH2"/>
    <dbReference type="OrthoDB" id="5966500at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 24" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028130911" description="receptor protein-tyrosine kinase" evidence="24">
        <location>
            <begin position="24"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="120"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="27">
        <location>
            <begin position="215"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="26">
        <location>
            <begin position="317"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="431"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="612"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="956"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_031559371.1"/>
        </source>
    </evidence>
    <sequence length="983" mass="109832" checksum="45496C657A21BE90" modified="2020-12-02" version="1">MKHCLSPLIIVVIISSLVNVCGGQVPDPPTGVNVTSNGPHSIKVQWDAMSNISAYHVYYQKKDVGAWSTKVVPENQTSLLIDGLMPYKIYLVKIKANTSNGMSNFSVQVQATTDEAPPSAASGLTAKFISSSDLEIQWELIPNEKANGVLLGYRYVVYDNQFQIVMNGTVSNSTNSTQIKDMKRCADYTVYLRAWTAAGIGKNAVFNITNICAPPKIINHKQIVIVTPNKAAVLHCNYTGFPAPSVTWMINDRTTTIQPGHKFILSGPPHERYIVPHLNGSLTFSHVLYHDSGLYTCFLNNSLGSAEANTTMTVSKDTISVVFVLNLTNEHFNDKLLEQDSSIFKNLSSTIKDEVLRLYSNTAKARIQDVIIQNFRKGSVMATLMVIATIRSGAEREDAENEILYTMIIETKDGYLGQIPVGEIIVQGAPPPPNVQIVSKQPKYAVLSLVRPTFFKQYEIVSYSIRYKKHGKSDDAYKTVETVKDKDGTMKGVVTGLDPGQFYFVQVASHRTVSMNAEGSIKYKTLEVDTPDIMMKQVMLTIVLPVGLAIIIAVVILFCIRPYVRSEVQADGHPPHMIPTRQFVPREENLYDIGRLLEEFPCRWKEIPREDVTVGKELGAGAFGTVVRAELKRDGKNIPCAVKMLKRFATEREHRDLFNELSIMSQIGNHTNLVSLLGACTVNGPLWVIVKLAEGGCLLEYLHKHRKPEYSDHAYMNVNPSTSTDDAEKLDKLQKLKFAHGIARGMKHLEKMKCVHRDLAARNVLLGKTLIPMVSDFGLSRDIYESELYEDVKGGKRPVRWMAPESIEDYTCTSKSDVWSYGVTLWEIETAGTVPYAGVDSGMDILNEIKKGYRLEQPNDCDDDVYALMLDTWRANPLDRPSFFELDERVEQMLAGISEYLEIQNDEEEDDDMRAYDVVHISEPELANGHVAQDDDDPSHDHNANEQVRYTDIHGATASDVPGIHEDTSRDQVDDETSIQTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVM6</accession>
    <name>A0A6P8HVM6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556700.1">
        <property type="nucleotide sequence ID" value="XM_031700840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVM6"/>
    <dbReference type="GeneID" id="116293418"/>
    <dbReference type="KEGG" id="aten:116293418"/>
    <dbReference type="InParanoid" id="A0A6P8HVM6"/>
    <dbReference type="OrthoDB" id="10062678at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031556700.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="17883" checksum="7384EFEEB5DF77AD" modified="2020-12-02" version="1">MILVRGRIGGELYTHKGGGAQYVCLTEHPTYANYKDGLGSESGNMWGTEYEIPGFNPFSTGGLSQHDAVCAVCHVRTRGSQLMIPGTYICPSGWTREYHGYLMSEKFYHHSSQYICVDRNAEYVPASGGNRNGALLYLVAGICGALPCLPYVEGRQLTCAVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVS4</accession>
    <name>A0A6P8HVS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin subunit beta-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556692.1">
        <property type="nucleotide sequence ID" value="XM_031700832.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HVS4">
        <property type="interactions" value="3046"/>
    </dbReference>
    <dbReference type="GeneID" id="116293409"/>
    <dbReference type="KEGG" id="aten:116293409"/>
    <dbReference type="InParanoid" id="A0A6P8HVS4"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556692.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="97815" checksum="FEEE01FDFA407394" modified="2020-12-02" version="1">MDLTHVLEATVSSDLNELQNAQKYLEQAALNNLPQFLVALVNELSDGXKSQVARMAAGLQLKNQLTSKDLNIRAQVQQRWLSLDANVRDHIRTRAVATLGTETARPAIAPQCIAAIACAEIPNGQNLDLMEKLVHNVTNSSKDMEALREQTLEAIGYICQDIEPEHLVTQANIILTAIIQGMQKDEPSIHIRLAATRALLNSLEFTKQNFEQLTERNYIMEVVCDATQSTETTIKVAALQCLVKIMSLYYQHMEEYMRVALFAITIEAIKSDVDEISLQGIEFWSTVCDEEMDLAIELAEAEEQHRTPEQASRFYAKGALMHLIKPLTNCLTKQEEFDDEDDWIPSKAAGVCLMLLAQCCENMVVQPMLEFVHNNFQSTNWKERDAAIMAFGTILEGPDIKTLEPYVADALPVIAQRLADDSVVVRDSAAWVIGRVCELMPHLVISEKFLVMVVTTLTQSLSAEPRVAANVCWAFNSLSEAAYEAASDTQTDEEPQTYCLSQFFPTIVEQLLEVTVRPDANQSNLRSAAYEAVMEMIKNSAKDCYGVVQKTTLTIMQRLQQVLHLERQVQSAERSQYNDLQSLLCATLQSVLRKINPQDXQQIADPIMNALLQMFDASSKGSICGVQEDALMAVGTLVEVVGVDFIKYMDPFLPYLELSLKNVAEYQVCIAAVGLVGDIARGLGVNIAQYCDSFMQILLLHLADENVHRSVKPHILSVFGDIALAVGHYFKKYLDAVISALTLASQFNVEKPDYDMLDYINELREACLEAYTGIIQGLKGDNEKAVDPEVLVMKPHIPHIVWFLEQVAEDPDHSEGTVTCSSGLIGDICEAFGGEVYPMFDKQSISDLLQEGRRSKNHKTKQVSTWASRKLRALKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW57</accession>
    <name>A0A6P8HW57_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116293526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556827.1">
        <property type="nucleotide sequence ID" value="XM_031700967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW57"/>
    <dbReference type="GeneID" id="116293526"/>
    <dbReference type="KEGG" id="aten:116293526"/>
    <dbReference type="InParanoid" id="A0A6P8HW57"/>
    <dbReference type="OrthoDB" id="10346341at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028340201" evidence="5">
        <location>
            <begin position="30"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="6">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031556827.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36449" checksum="DA4D9C602D08EC92" modified="2020-12-02" version="1">MKIVRSKVKKNALLVALVFASLRNNLTEGKMCTAKNSESNSFLNGFVFDSSKVDDILSCVLKCSQNELCASINMNILSMKCELSKSTKRKHPQNSVYQPQMIYMEIRDPPGFTADNPIPSCKWIKNLDNQAKSGVYWMKFNEPSSASFQVFCDMTTDGGGWTLVYSYTFTQYSKFTSASNAVTPAPYWPVNWLSSSYWVPRSMTTPLSESSRSAMGFALWKKIGNEFLLKPNITNWVSCVEGTGSLVNWVSGSLTCRVVKAITSTCTNVAAEYIRVSNSGLCLQLNGKFYVCLEGSIRSVWPVHDPCGTSNAGNHLQNIPNPGGALYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWC9</accession>
    <name>A0A6P8HWC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116293640</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116293640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556960.1">
        <property type="nucleotide sequence ID" value="XM_031701100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293640"/>
    <dbReference type="KEGG" id="aten:116293640"/>
    <dbReference type="InParanoid" id="A0A6P8HWC9"/>
    <dbReference type="OrthoDB" id="6088515at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="1433"/>
            <end position="1470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031556960.1"/>
        </source>
    </evidence>
    <sequence length="1601" mass="180279" checksum="6E0D0FBBBFF7E859" modified="2020-12-02" version="1">MAARGTTSSTTSLPPLIITPPTALPPRIIPSSVPVTGTSSTFELREEQKRWLVIGICLHKILLPTLRDYIKSEMLTHYANLKSNHNIDKQKYPTRLKKDSKHKLNYGSINNNEANHGKKVKLYDYGVKSEVDLAKLYLSPNMAKFSGLDDSCDLSAVLGILPLASVFSSVVQSLSNDVKTDIRNEWGHCNFGVWSKTKFLKCFQQMDSLVRAFKLSPAEQKRVTDELIDWETKGVQLCTGNMVDADLVKFVQQEVFQLHDEIKRLWHNHDDEVQKITDSLQTAEEAIQKYQEVTKSQLESFKTSHESTIHKVNELVDVTTEIAKDVDSLKASQNEMETEIVSVNQTQDVFAQRINEGEMKYEILDKRVEALESAIETRSIDRAINIFQAPNRIPCFHGRGQELLALEGQMKDIVSPCKMTAVCGLGGTGKTSLAIEHIWQKIESYSGGVFWISGESNHLFNLSVSEMARQIGTFDEDFKTTLSKTLDWLQNRHDTWCLVIDNLDELELSTDMMKLVGGHWKRQSCGHILITTRREKKKLKEDISDLTEDSCIELKNLSASESAEFIKKRTERHGDEDDIVIEEPVVELGCLPLALDQAAAFIKNGKDISFSDYLEQYKAQRLKTLKRSKAHYPVQDTSKDRIAVHTTWQLNFEYVSQFSEEYGIGQAAALVMEVCAFLSPDDIPNEVLNQGLPKINNEDLLKCVSTAFGKNDISSVLTKFSLFQKFSKKSFSVHRLVQEVIQDKVNEEDRLKEVLQCASRMLYYAFANNRSPVEVCQSFQGDSVFNQENPPSLNLWGKLGAHASVLLYHLIQSSQKHDEIRQQVLYSEESVMLLNEGSVYLNVCRQTKEAMEQKESKLKVLTGLEVPLTVEKVKYINFFDVPLKDFQFKLISHCMAAQESAVSKGTQCKAEGAQKRREADCLRQKGNEAVRSKKFEEALALYTAAIECIRDDPRLYSNRALCELKLQNPEAALSDCESCLNIEERNSKALMRKAWALYELSKKDDREPKLQGRMRAAAALAVHYDSTLLKDKLFNQMFPNVEFKELSNSSELAASFMYSVPGKTYLLHDGHYDFHGAMLDVDTQLVALKRHQVTLIFVDLGVFQSRLYAEGLVFAKGNGSIVCQQNGSLDFFKCKISGGFSCCKDYPDCNGGTGCIAGQFFGIKACDRTGKFGASEVSGVIGTPSIRIMQESDCNVENCDVTECGGKAIICQGEGSVLRVASSRVYGNPQSGLEVVSGACLVAVNNEIYGNGFRGIMISPSPGTCEISKNRIYENKKDAITVFQTDKKLVIDNNRIYHNFGFGIQLSNCGQGEIMENEIFENSFYGIGFEKTSILVVEKNVIYSNKCGGIFIGPNHAGRIVIESNIVRDHNGSWLVNQNVPQPRCRFPQRINATKAEFQYYAIAPILCDNELLKNEECMFHPKERLISVQRECAFCRKSNNLSRCSRCNMASYCNRKCQEKHWSKHKALCSALNDQYSLTIELKQSSECTLVFQNMHFGSHLKGIGEGPKPDPKSNQRFIVKIQTQSGNCHPLQILTAYDKSLSVYGEFQSPEIFNIVMECGVLGKFVHFTSKKAFFDATFVDGGKKLKIYMGKLAPYQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX73</accession>
    <name>A0A6P8HX73_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC116296174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116296174</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560003.1">
        <property type="nucleotide sequence ID" value="XM_031704143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296174"/>
    <dbReference type="KEGG" id="aten:116296174"/>
    <dbReference type="InParanoid" id="A0A6P8HX73"/>
    <dbReference type="OrthoDB" id="5988225at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF161">
        <property type="entry name" value="LAMININ G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="16">
        <location>
            <begin position="158"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="530"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="568"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="606"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="16">
        <location>
            <begin position="649"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031560003.1"/>
        </source>
    </evidence>
    <sequence length="857" mass="92748" checksum="AD98947EFB60BAF5" modified="2020-12-02" version="1">MTEMALKGHVSKTLEKITFTQCSLRCLREDWCVSVNFEIQKTMGKCELNDYGVEDETXVSIEKGEFEKKXGFVYTQLRPAGSGCHDNTCKNGGTCVVECNKWQPQCSCPRGFRGKRCEDISECSSNPCLHGGTCTDQVNGYSCTCAAGYNGANCENSLNCEVYFPSSLSLFNAIVIRSALPADLDTLTVSFWMKVSDQRAILYPFSYVSLSVISALIIGIKDDGMAEVTVAGETKVLFSGVKRDNKWQHCAVTWKSSTGNVSFYRDNKLKGSETGLKIGEKVPSGGILVIGQYQGSYGGGYDSSKLMIGYLADLNIWSRELTSCEIKTLSSKCFSSSSSAPVLPWSTIISKPLGGELSKTCPATLDKTSLAMLTSKIMFLFVTFMSFPYCYNEPNVICPTERSAGALISKKDMALKGHVRKTLEKTTFIQCSLRCLKEDWCVSVNFEIQKTMGKCELNDYGVEDETGVSIEKGEFEKKDGFVYTQLRPAGLGCHDDTCLNGGTCVIDCIQWTPHVQCHCASGFRKNRCEDINECSSNPCLHGGTCTDQVNGYSCTCAAGYNGANCENNINECSSNPCXXGGTCTDQVNGYSCTCAAGYNGANCQNHINECSSNPCQSGGTCTDQVNGYSCTCTGGYSGTRCETLLSSSSNCELHFPSTSTSNSIVIDSALSAELGSFTVSFWIKVSHPTVILYPFSYATTNVTSAWFIGIKEDATAEITVAGETKSLSSGLRRDNTWQHCAITWRSSTGKVYFYLNSVLKGYGMGLKIGEKVXSGGKLVIGQYQGSYGGRYDSSKLMIGYLADLNIWSSELTSSEIKTLSSKCFSSSSSAPVLSWSTIISNPLGGELSKTCPATCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXC7</accession>
    <name>A0A6P8HXC7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Proteasome 26S subunit ATPase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116293885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557242.1">
        <property type="nucleotide sequence ID" value="XM_031701382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXC7"/>
    <dbReference type="FunCoup" id="A0A6P8HXC7">
        <property type="interactions" value="2094"/>
    </dbReference>
    <dbReference type="GeneID" id="116293885"/>
    <dbReference type="KEGG" id="aten:116293885"/>
    <dbReference type="InParanoid" id="A0A6P8HXC7"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557242.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48424" checksum="663F9A03617BB7D4" modified="2020-12-02" version="1">MPDYLGKDQRTVKEDEDKNDKPIQVLDEGDIALLKTYGAGVYSRSIKKVEEDIQSILKKVNELIGIKESDTGLAPPALWDLAADKQTLHGEQPLQVARCTKIINADSDDAKYIINVKQFAKFVVDLGDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDIGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIVFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKVEFGLPDLEGRAHIFKIHARSMSVERDIRYELLARLCPNSTGAEIRSVCTEAGMFAIRARRKVATEKDFLDAVNKVIKAYAKFSATPRYMTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXU0</accession>
    <name>A0A6P8HXU0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Polycystic kidney disease protein 1-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116296293</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560176.1">
        <property type="nucleotide sequence ID" value="XM_031704316.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HXU0">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="GeneID" id="116296293"/>
    <dbReference type="KEGG" id="aten:116296293"/>
    <dbReference type="InParanoid" id="A0A6P8HXU0"/>
    <dbReference type="OrthoDB" id="5967971at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000022">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027580202" evidence="16">
        <location>
            <begin position="20"/>
            <end position="2858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1770"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1977"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2018"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2154"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2197"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2285"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2537"/>
            <end position="2557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2577"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2626"/>
            <end position="2643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2664"/>
            <end position="2692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2728"/>
            <end position="2750"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="21">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="542"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="20">
        <location>
            <begin position="862"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="19">
        <location>
            <begin position="1606"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="18">
        <location>
            <begin position="1816"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="2387"/>
            <end position="2400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031560176.1"/>
        </source>
    </evidence>
    <sequence length="2858" mass="322950" checksum="7A36FC71D10E2BC2" modified="2020-12-02" version="1">MKMILVMILVACSVWETSANEVWDLGCYSQDRSNKEFIYSAGNYKASDTSIQDCTSACALTTSPFKYAATEGSYCYCSNTTDKIAKVSDSKCNEVCTGDVCIGPAYIRVFNTNVSIEGLSVHTPDVGFLLQDVGFGATVVKGETNASYTFDFGDKSFVLTTCCNTTHKYTQTGVFEVKVSARNSQSGPIRASGWVSIESSLGIVRIKCPEEIVETGNVTKVTAYTTQGTNLRARWITNNQGEAKYFNMSDATIVGVGSKATFGNISGSLQSDGAFIKPTSMFNRDGYVMAWEVYAAKTGTIKLQVYRPVCSNPAELFCPLNMTCIPAGLACKPSTTFKCPGNGNVCLATGHCLQGCAVQNVSFPGSSTPIVDYRLIQETIVNISKVGYNIFSLPPHKAIEVQAGDVIGWATNSSAGDLAFELSLEEPQFYYPYSSFSIVVGSKLSKSAGAIKQNINHVIRAHXSRASFTSNELTFDNAGIFNVSVIIKSQQGNSFNDSLQFCTVSVQERITNLQIEQPLCYDKSVSYATGKSFDLIPKTVKGSNVTYTWNIANKTVVTDSNANMQIDIPGLHEVTVMASNNISACDASTIISVQNPVGLIELVNQSQNIEVTIPANFSLRFTRGTNITVEVSFDGVVTDTFFISEAANTTREVTHIFSTGGTREMVVKASNNISPPLGQRSETFPIEVKGKIGQLITEVEPQLTSDGVLEIATGQQFQITIYSTLDIPINYSLTYEISNIKDSKITLKGKASFLGTFESKDYTGQISINATANGEIIRLSIPARVTWCGPPAIFKPANYSKKSPLMKTMATPLELKYRSVYTKREGCSYGKLIYKWRIYKMESGLYSPVNHYQPDSEEVFKVPLMILKKGNYTINMTLTYTGTGHQYLYETFFDIRKSELFCLINGGNIRGVPYEPGSAISLNGEGSVDPDQPEGPKLAFKWSCKLNDDNNTKNVFSAPLNSDVPTYCNSTTFQDTPIEPNAAISNLPIKYFRENASYVFQLRVSKNSRQKTCQQKILILSEENPLISIQCKSNCKDKVNPQDRLVINAFCSNCKNDTRDLSFKWHLLDNRGKLDAALYEEPSTTTTGWDKMNIVLRENTLSENKQYHLNLEVTRRSVTTVTQYYIVTTSRPYGGSCQVLPEEGYNIESKYHISCKEWQTEDPQILYEFHYINVRQAEAKISSLPPDKTVSTLWYYGPFHETPSSSLPIGNKDDDYKLSIIVKIYNRYGAYSNYNLSAIVRPLSTKETTAKIEDISKQLEGGLSEFNPEENAQNVLQLVTAASSLINNDKEQNTETKAKLRTLMVDKLSKIQSDELPMIAEKCNALSLAIENESEVTSDTQITATDSLKRSSEALKRKARVKGYQSDTPLKLEETAQVVFTGISHTFSASESTTQDYLDQVLENLGKTGPKSRDWSVRIREWKGEDSADAAQNVVSTLYGAINQLSDAIQENKVQGENETLVTTKTFGMQLSKTVWNSIGNNSLPVRGEDGKQVGSFVLPKVDDLMSGAEVGTDETIGIQIVRFPENPVRWDKDLSAFMNSSVIGIELRNDQDKEIPVSNTRKDIEIFIPVTGTNVEHYSKTFHSGTLKNFTYHYRVGNSQVKNEPLLVHIKPNKPLTLYLSFRTYPTTTTYHLKIQLPCLNESLPWPYSKVDNYTILIMDLKELGENLYLALEPEELVKSKGLETPSNMELVPVSDVVQVNYTVDVRSVGCKYWSEKTQDKWSGDGCRVGNKTSYSSVHCLCNHLTFFGSVVVKPNPISKPTFQKFKEGYINTIAVCVIFIIYFMALIWARRKDRADMIKVGACPLPDNDPTDQFRYEITLWTSMRRGASTNSKVSILLDGEENDSEARTLEDPERKPFQRGSVDTFLLTTPYLLGPLPYIRIWHDNSGGSWFLSRVMVIDLQTDEHYYFICNRWLAVDEDDGQVERLIPLASKEELTEFQHLFVARTRRNLSDNHLWFSVFARPASSRFTRVQRLTCCLCLMMMSMMTSAMWYKDVPVANQDTNKFAGISFTWKDVFIGVVSSLIVFPVNLIVVQIFRSVRPKPHRITHRKIPMPPKLSLTVTNLSTYNKMKDCSDDSNKGSNNSLESMHEKNNSKMRLSINDVHTDVDRVSFTSSPLLVDRRQSTMWDSSGTTRLQRLVQWFKRHSSLPYYFIYVAWFLAVTLTLGAAIVIILYGIDFRNAKSYKWLLSSMVSFIQDVMITQPLKVLGTAIFFALIVKKPDKGEFEISSDAAQLAEDEDWLYQTGDQTKAKKRKKTKLLPPDQAKLMAMRNTRMKERKMHSVIREIGFFYLFLCLVMMIAYTHKDYYSFIQTDNFKKMFVANFQEIKRDLDFWKWSNEQLIPNLFPDKWYNSKPIPKEGFASDHNSQMVGGARLRHIRIKPGICEVPARITFITRDCFSQYSISDEDHAEYTTSWLNVTKYSKPVNRKDVNWRYQTWNQLDGYPVWAELNTYAGGGYVHVLEPGMKNSEKLKKLEKEFWIDRHSRAVITEFTVYNAQTNLFTIATLVAEFPATGGVIPFVTIQTARLYNYTKDYMFFILACECLFVLYILFFLYQELRKMHKEGSAHFKQFWNIVDIVILSSAGFGIGLYIYRLLTYKDVLEKSRNAPFQFKSFQLAGYWDEMYTLSIAILVTFSTIKLNKLLRFNKRMSLLSSTLKHAAFPLMMFGLIFGILFLAFTLIGTVVFGTAVRGYRKAGSAFTSLLSLMLGKTSFLEMNETNRILGPVYFFCFMFLVSMVLINMFLSIIIDSYHEVKRDLEKQDNEYEIVDFIIERFKMWSGIGKADKPEFKHRHVRWDVVESKVKSLNALTGGGIDHVSKLESRIEKLIQRTDLLYTEIFPEKRRRPTKAMRHKHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY17</accession>
    <name>A0A6P8HY17_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-rich adhesin for platelets-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560263.1">
        <property type="nucleotide sequence ID" value="XM_031704403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HY17"/>
    <dbReference type="GeneID" id="116296391"/>
    <dbReference type="KEGG" id="aten:116296391"/>
    <dbReference type="InParanoid" id="A0A6P8HY17"/>
    <dbReference type="OrthoDB" id="10497980at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560263.1"/>
        </source>
    </evidence>
    <sequence length="887" mass="91400" checksum="F8E6551F3BE4AC0F" modified="2020-12-02" version="1">MFELLSIKKTHVGRFIYLSYWKRGIRLRIVATSSTLDPTTQTSSSHFLAVSSMSSSFSTAGLTSIDITPTFTSSSPKTPDDASLPYSSQTSSSNLSSSTSATVSLSTISVMENSSYSSQTPSSNLSLSTSATVSLSTISVTENSSYSSQTSSSNLSSSTSATVSLSTISVMENSSYSSQTPSSNLSLSTSATVSLSTISVTENSSYSSQTSSSNLSLSTSATVSLSTISVMENSSYSSQTSSSNLSLSTSATVSFNESSNSLSTVIASSNTSGVLSSTMSLTSPSSTLSSLPTAVGVASSSSSSLSNEQSTSSGIISSMVQEPKTSSTLSPLPSTSQVSSLLSPSPSIISSLSILPQALPSSLPSSLPTSPQVSSLLSPSPSIISSSSALPGITSSAVSQAEASSSMSTFATSSQMASSSSPSPLISTSPSALPLTSSTELHALPSSSMSAVATSSQMAIRSSPGPSISRYPSTLPGITSSTVPKVVTSLSISSLPSTSQVASSSSFLSPSISSSSSTLPGITSSTVPQAVSSSSMSSLPTSSQVVSSSSSSPSISPSSSTLPGITSSTVPSPIFLSTTSVKASLSSSRSLSLTFIPTVMPSSSQLATRVNGFSSTILHPTSTTAVPSLSSSSVVPYTAVNNTVTKEQKADAIELIFQNTSLSNWNEGMKDKVLQAIVDSIVKYCRSESTASKCKAKQENRRKRRSASPTTSTFNITKDNIKFLPGYPKEVNGQLVLAFFVELPNGAALPTGNTTNVAMAIPKEAILSAIRDSIQKIEEASGKKISKLSTFEEPRTNTDGEKDNTVELVIGTFFGALFSIVITAIFVKIVKSKKSRRQKISPQGNDETDDRIAGNTLITHDVENEGCESSTKKVEVINVQVLNSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYY5</accession>
    <name>A0A6P8HYY5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116294422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Identified in the spliceosome C complex. Interacts with SNW1/SKIP. Interacts with CDC40/PRP17; this interaction leads to CDC40 isomerization. Interacts with RBM22.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031557875.1">
        <property type="nucleotide sequence ID" value="XM_031702015.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HYY5">
        <property type="interactions" value="1807"/>
    </dbReference>
    <dbReference type="GeneID" id="116294422"/>
    <dbReference type="KEGG" id="aten:116294422"/>
    <dbReference type="InParanoid" id="A0A6P8HYY5"/>
    <dbReference type="OrthoDB" id="5916692at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031557875.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17701" checksum="637CEA8AB2A680EA" modified="2020-12-02" version="1">MADESASVYVETSMGRFEVELYWRHAPKTCKNFLELAKRGYYNNCKFHRVIKDFMIQTGDPTGTGRGGASIYGPTFEDEITRELKHTGAGIISMANSGPNTNGSQFFVTLAPXQWLDGKHTIFGRIKKGIGVVKRIGLVDTDTSDRPIHDVYIINCKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZN5</accession>
    <name>A0A6P8HZN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein mab-21-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116294646</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558140.1">
        <property type="nucleotide sequence ID" value="XM_031702280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294646"/>
    <dbReference type="KEGG" id="aten:116294646"/>
    <dbReference type="InParanoid" id="A0A6P8HZN5"/>
    <dbReference type="OrthoDB" id="5961151at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF42">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="10">
        <location>
            <begin position="163"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="11">
        <location>
            <begin position="338"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031558140.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="51591" checksum="D01180E0F41BFBFE" modified="2020-12-02" version="1">MDSQLPIATDEIQKAKIPQKRQKSSKKRSSFQLSKKKSLSSTCLSAKSGLNKKTLSETNLLSSKRYSSLTQLNMLGSCKSLDQMEGKDVNLEELFSRELQMFYAKKVENGRIKSLTNKRLAFTTAFKVLINLQLVNDRFTATDLLQRNPKYCELTEIRSNWFEFEVPVYLDGCDQNVFXQSADEGGFVRLAVDSEQNFNWSDCVTDEGFLSASLVRSKLQLTIQKSLIAMNSNVQMGLDNLPDDIDSVTVYCDGSTVVLDINGGQLFVDMVPSIRLHCSSLEFFKRLSKSAVPSHALAKPCDRPMSDPESLWMLSFASAERKKVLQLFPTQRCLLEILIELRELDDLFGELSLSHMQTTLFYLVDEMSDPYDWRENEMGERFIDTLCYLENFLDCKYCEHYFVKSANLLSGMSPVTITKLKDKVRRIVKPSCVACGLASLFGPHTKIKCNKIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0K0</accession>
    <name>A0A6P8I0K0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116297939</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562124.1">
        <property type="nucleotide sequence ID" value="XM_031706264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297939"/>
    <dbReference type="KEGG" id="aten:116297939"/>
    <dbReference type="InParanoid" id="A0A6P8I0K0"/>
    <dbReference type="OrthoDB" id="5959426at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF6">
        <property type="entry name" value="MITOCHONDRIAL ANTIVIRAL-SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562124.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33597" checksum="724B92C35DB89D9F" modified="2020-12-02" version="1">MKLTYNPAFYSSNKILESKLKVNKREQKQNTKHNPVIEPADVSKVKKNPFLSHENPYGLLRRVWFIVTLYWCRRGCEGQRQLRRESFTFDLDGEGKEYATMTHXEQTKNHQGGFCDKQSYENETRLYSTVNSKQQAFFQRPVPIFTPEDPVWYENKPLGVNKLGDMMKSISIGAGLSKVYTNHSVRATAITMWSNAGIPTRRIMSISGHTNEQSILSYNRRPSVQQLKTCSDVISSALTDSEGESRRLDRDPRAVSSASTSVQVVQSEMAIDSIPESIFNGCSIQNVNVYVVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1P9</accession>
    <name>A0A6P8I1P9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centrobin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116295193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558810.1">
        <property type="nucleotide sequence ID" value="XM_031702950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1P9"/>
    <dbReference type="GeneID" id="116295193"/>
    <dbReference type="KEGG" id="aten:116295193"/>
    <dbReference type="InParanoid" id="A0A6P8I1P9"/>
    <dbReference type="OrthoDB" id="8190486at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051299">
        <property type="term" value="P:centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902410">
        <property type="term" value="P:mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038923">
        <property type="entry name" value="Centrobin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439:SF1">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031558810.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12562" checksum="35EA180745207EFC" modified="2020-12-02" version="1">NKEIKHCEQQIQELHTKLLEIHQDLAVLVSSERKKDVMIEQLDKTLAKVVEGWKRHEQENLLMASTLKPEREVQEQSHKKQQEILLQFEKELAQRATEAEKEKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1T2</accession>
    <name>A0A6P8I1T2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116295211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116295211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558835.1">
        <property type="nucleotide sequence ID" value="XM_031702975.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295211"/>
    <dbReference type="KEGG" id="aten:116295211"/>
    <dbReference type="InParanoid" id="A0A6P8I1T2"/>
    <dbReference type="OrthoDB" id="5988080at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031558835.1"/>
        </source>
    </evidence>
    <sequence length="914" mass="104839" checksum="A2CA7525A071787F" modified="2020-12-02" version="1">MELQAIKAILREFKACRSILHETPLANELKPLIENVKFKLASSVKEEYQNQPLKLVKSSPELKLRLQYLKEFSAQPNASEKSKNXDVFAKDFQTFLDGRSTLLVDNXLEDAYKIIQDSERNEEDDFVHKARIEGVVLRTSPSYVSLITLDGSEELLVKVNREFVGLGIKVRTGDVISVVNPKLTQSKTSDLDPELKCCYDMSKDEVDIFFKNVRQLLPTDNPLGILEKFERSLAVWQHIINVSIMKEENDKEPDGEVSKNILEICKIFGGFQAQTQMTTIMIRFWDALEDSRFFNKALPEIIKDEAWQRNNINLVENVLENLFKAHPECAVRAIGILKSLTCIPVESRVEFNRKLFSMIAPFVTGVSEKPKNPESSCSHGISEVVVENFVENVKQLKDNPFGILGNFERSLAVWQHIINVSIMKEENDKEPDGEVSKNILEICKIFGGFQAQTQMTTIMIRFWDALEDSRFFNKALPEIIKDEAWQTADNINLVENVLENLFKAHPECAVRAIGILKSLTCIPVESRVEFNRKLFSMIAPFVTGVSEKPKHLKWNQKSVIPLPTELEHDPDFDFRGLQPVRVKKDEDEDEEKKQKKVNKKKNEIAYKSEEEYIETYYALLRVECFHKVKKGIHSFLVKRKCDPKDNMLYCVKLIEISDRNELPIHEGLSLVLECHHNNETDKSDLDADQDNSKWLMLGNLVCLLLDATFENPVWGVISKKRTAEDSKQKHVHVSLCTKNNRLRDSEVITELQELKSQGLPAYMIESDTFYPAFGPILEVLKNKVTVPFAEQLVKVKKSPLASRQQSPDHSVAGHDECHFQWMFAKLLAKHKMKSQQQNSGPNYLRHITEPPKWDVIFENPSSSDCSVSSGFYDVVREFKKMREDPKSKPKLDDKQLDAVEQALFNKVALIQVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1U9</accession>
    <name>A0A6P8I1U9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562519.1">
        <property type="nucleotide sequence ID" value="XM_031706659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298270"/>
    <dbReference type="KEGG" id="aten:116298270"/>
    <dbReference type="InParanoid" id="A0A6P8I1U9"/>
    <dbReference type="OrthoDB" id="5971103at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="50"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562519.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50546" checksum="5E24AB501CEA075F" modified="2020-12-02" version="1">MERAPMNNSSIIEAKVQDGKLVYIFDKNQHAQTLLRNLIAMQGNDEGSLTDVVITSKENEQFYFHGPILAALSKNLEENLLKRGLGSAASKKTKIVMEENFSSEAIQCLWDYAYTSVVTLTPSNINEVKELAEHYGIVXLMQECKELLDRETPFGEGQDKEEVGFKDLPEIILDRLHNFHEKKVLCTAVITDCLSSTRFPCHGAVIAAACNEFFFELVFGDGNNFIDVDDHTLQAMGPFLQYLYTAKLMIDEATVLPLIRFAAKFSIPSIGNACCNWLKFTLTANNALPFMTIAQDFLNKEKNLSSGRESQDDVSFASALADLYQYARXFVLRNFFSVQXSVQYLGFSLEELIDLLADDDLGVHSEEDVFYAVMKWVCCSPETRANDLPVLLQAVRLXYIPAEFLEAMLHHDLMINNSRCIQMIEDAQTIVLPSTPRRRSTVQRYDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1X3</accession>
    <name>A0A6P8I1X3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Allatostatin-A receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15" type="primary">LOC116298286</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562536.1">
        <property type="nucleotide sequence ID" value="XM_031706676.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562537.1">
        <property type="nucleotide sequence ID" value="XM_031706677.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562538.1">
        <property type="nucleotide sequence ID" value="XM_031706678.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562539.1">
        <property type="nucleotide sequence ID" value="XM_031706679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298286"/>
    <dbReference type="KEGG" id="aten:116298286"/>
    <dbReference type="OrthoDB" id="10049706at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031562536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031562537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031562538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031562539.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51448" checksum="08E5391E7A221805" modified="2020-12-02" version="1">MNESIDSTERAIHNNTVSSPSKSLVIITVVFVFISVVGTTGNGLVIMVVKRLQHHGKRSXVHTFLLHLALSDLLVCIVCIPLTILVNFLPAKAHSLSSNITCKTMRFLQFLAPTISIMLLTVISIDRYFAVVRPLHNKIFLRKPKVMVCIAWLISIIQFLPTFHFSKVVNLKRNNHTIGYCTPIPYNTKSGYGFLLFVAIFSFVLPLIIISLMYGLIIRVVWFRHQQLNETSSTNRNNGEQLFRKSKKKVLQMLMIVVVAFICCWLPFVIYCGFIEVNTATFPNPVDIVRIATYCLALFNSILNPFIYFFSNTLLRNACIDLVFCRKFTMPSTSNFGIGSPSLTKKLSSTRLSLSPNMNTYLTDRRGRHSVHSMLLAKADXSKDPSPLGRTRRLNNGLGASLRRQGSLPIIAMSDSPWMRRAADSRLSPGVDNVGRMPKQLPTRTTMEDREMTTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I298</accession>
    <name>A0A6P8I298_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116297771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031561923.1">
        <property type="nucleotide sequence ID" value="XM_031706063.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561931.1">
        <property type="nucleotide sequence ID" value="XM_031706071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297771"/>
    <dbReference type="KEGG" id="aten:116297771"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="RF_methyltr_PrmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Release factor glutamine methyltransferase N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="137"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031561931.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36609" checksum="F768A4B9A9103529" modified="2020-12-02" version="1">MISKAAMIAYTMVNHHMLGQVQILGSLSIKRLISGARTLNNDALHEIRTRWMDKLEKAGVPEADLSVKYIIEKVLGQDSELTLEKQVEINEMCTRRLKRKPVQYIIGDWDFRDLXLLMKPPVFIPRPETEDLVDLVGSYHQLSTINHPGSFRFLEVGCGSGAICLSLLSENQETSCVAIDVNPEAVKLTKLNGKRNNLLDRITVTKADIGNFTCNEQFDAIISNPPYIPTQDMNHLEPEVKSYEDRKALCGGEDGMDVIKDIFQAAPQLLKPNGSIWLEIDLSHPTKIRQWIHENPSSALKVNNFYDDFTQRPRFCHVIMPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2H0</accession>
    <name>A0A6P8I2H0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116297595</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561716.1">
        <property type="nucleotide sequence ID" value="XM_031705856.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116297595"/>
    <dbReference type="InParanoid" id="A0A6P8I2H0"/>
    <dbReference type="OrthoDB" id="10072494at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23385">
        <property type="entry name" value="beta-trefoil_Ricin_MRC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLAT" evidence="7">
        <location>
            <begin position="357"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="9">
        <location>
            <position position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561716.1"/>
        </source>
    </evidence>
    <sequence length="2120" mass="232847" checksum="FA8BD55EFD8FFECF" modified="2020-12-02" version="1">MENRNQYPKQSHQNLNSAGFRNPGSSSDSQGKYLLEYGVGKLHVSLGNNQLENNKLRHIQGRHQPAIGAGPIRFQSASHHVTVLKYSSSNVPSKNDQVISGRNGTSPALKTNNVIHNRVTQERNGFEKTSQNNQLQDVKENDGMLSDTLVQQNMIKIEGKVTPTKYNGDCTGLGLMFEGGHVKLSSKSLTKIPAKDMTFLVWIRLRTVNQVATIFSTAVSGGGRQILELRPAEGSMPNGRLKWTVNTDKTSTLFSIETENIIPSGIWTHVIAKYDATQGRAYLFVNGEKTLKLKNVKKGAKLPWGDDIVIGGLTDESYKVTFPFLGGILNMRFVEKPYQDAEIDAAYKHCKPEDAGTPYLVTVCSGEKLGSGTTSGVYLQITGETGQFGEVKLGSRFSAGCTKSVTIYGPPVGRIQRISVRKSNKGIISKSWILDKIEISTETVPRITQVYHFKCSCKFKEGQLQRYLDAKPRVDGGWSDWSEWSGCGTGMCGGDMKVRTRACTNPVPSEGGKICILPDKTFANFDKQTEECSVNGDWGAWSSWSECDQICGGSKVTRTRACDNPAPKNNGQDCVGPKEETKMDCTQECEDWPVNGNWAEWGAWSACSKSCGGSVVTRKRTCSNPAPLRNGLPCEGDDTETATDCTVHCPIDGAWTEWGPWTECSTTCGPGQQMRQRNCTNPPAAYGGKDCSEKDSQEVQECKLVACPNAVNGNWGDWGAWSECSEKEFCDLGEKKRTRKCDNPAPAEGGDPCIGLDTEDEICPKDNCKPANGDSIQVKPSSFIAESCKAETAYFAGGTKASELPDSIYGNQFKAITDEXKTSYFSKTEENNKKETITKFCFQPSRPLSIAKLEKVFPGYTQVPSLPEFKKPPGTDNSAGLSISLKADGSLFGGEFSLGESGSYSPIKGVKLKKSRFFFKTKSGERGIVAYAKHDFVNNVFDVEVKQGPEMKGKSKGQTDLETIVNTLSLPQATSLVGSPTVTAQDTLKNLFLDYLVNLGLAKVQVNGLSEAATATTKRISGAVVSGDTQELFYLEIIKQKDFAIGLSSDKATFHNFMEMILKKLKKKPGSFELFGSMTDTTVGIAFAQKGFKVEPATKFEKEPLKSAAGASMKEGVFIAIRTKLPQTCQSQVCELAHAILGKDSWLMFTGNANKKGLDFTAAVLDRKITETIKFSKLELYVKAKFLPPTATVGFRMAIKFPVEGEVYKDNILQPKSELTLGGSLEISTPLVFGTTLEMKGIWRKVFGISFLAIGDIRLSFKINAAGIPTQLGFSGTVQLGKNCYYPQDFEKNGMCIRGRVDFSLGTALSTQYVYGDISAVTVGKVFRMFGSKLELPEKIASSGFEKEVVFSFAGKEQTIQFQGVEKKLKTGLYVKGALDLLGFSVVTEIQISPKIIFFQVELSPFELPGKIMLVRSLTDKKKGPLFYAKATTDPLAAEVFLQGAATIFGVGTEVKFLFKPSLIEATLKLALPFGKLGAELYVKGSYGTSLKETGFTAKVNITSGLLQVQKDASGDVEKTVNLARGKIQTARDKIKEQRESCEKRVTNYCEKCQENVCDSISNNCEAALDQFKNYIGEAANKFGGWFVGAAKKIASTFKNPRERRSVEFFPGRAQMMTRLRRKRFVGNYLCKTLAPAICKGSKKFCQASCTLNKHITKGVCKGLDLAHKSLFLVEDSFHWAKRIHDVVVKDMLAVHGIVFELELSSNLGARVAALIDITIMKVRRKIGLDISLANLVEMAKEIVNKAISEFKNMLSKRYTQPKYDKPNTVGDVMVGAPFRIKNVGNNMCIKSPGPDNKGAGFSTSACSSADTQWVYTLTGALMNIHSGLCLSFTGTGKDLKIVQQDCKINDENQRFTCEHNRIFLGNSKTDCLIEKASVITAGPCKPAPADETEDFETPEAERWVVNDDPRLKVCDNYVQDLALNKPATQSSSFNKNDLDQEELKLLDPNDRETILTKTGAELAVNGDMSFTLREGSCSHTSQTKDPWWKVDLLDEHIITDVSIQTASEGPKLDALENFEIRVGILQEFQKNPMCGERVAAAHLGELWTSTCDPAIPGRYVSVQTFGERFLTLCEVAVYARKDNQGKCSTELKRRRSNIATVPHKDCVLKRAQITYGRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I811</accession>
    <name>A0A6P8I811_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxynucleotidyltransferase terminal-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116296868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560835.1">
        <property type="nucleotide sequence ID" value="XM_031704975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I811"/>
    <dbReference type="FunCoup" id="A0A6P8I811">
        <property type="interactions" value="1862"/>
    </dbReference>
    <dbReference type="GeneID" id="116296868"/>
    <dbReference type="KEGG" id="aten:116296868"/>
    <dbReference type="InParanoid" id="A0A6P8I811"/>
    <dbReference type="OrthoDB" id="5860246at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041384">
        <property type="entry name" value="DNTTIP1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026064">
        <property type="entry name" value="TdIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049121">
        <property type="entry name" value="TdIF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399:SF2">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18192">
        <property type="entry name" value="DNTTIP1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21229">
        <property type="entry name" value="TdIF1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNTTIP1 dimerisation" evidence="5">
        <location>
            <begin position="84"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="TdIF1 C-terminal" evidence="6">
        <location>
            <begin position="214"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031560835.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44047" checksum="B5BD6860424C65F6" modified="2020-12-02" version="1">MAEPPSAFHEFEYDTSFPKRFRYSRAFDEKIVDKNEEKNETKKDTSPSPFNMTPRNFPKKRNHYIRSSIASYNRTRGSSLGGNKALELVRAALQPSLNAEIEQVLKSYHEMFKMAAVNARENTGETITEEQINAVIRKSLDEAKLMYRVTDTRGSVEKVKYERVERGNSPSRTVVRKKRPRLDVDRERSTVASRAADSKTIAAYDWDPEGINEETEFVMGVKANKALGFAATRGKLYYRHPNLFKYSGDSDDKQWLYEHSQLPITGGKAFLMIASEVRNLVQTHTEYRENENIKIDDLKGFKVPLSMIEKMKAYMRKAKREAVRKRAEQTKAFPKPEPKIEIKKEPEESKESNVLESKPQEQPAKNEETPKTVSETQTSVSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I885</accession>
    <name>A0A6P8I885_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Olfactory receptor 2M4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116297233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561282.1">
        <property type="nucleotide sequence ID" value="XM_031705422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I885"/>
    <dbReference type="FunCoup" id="A0A6P8I885">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="GeneID" id="116297233"/>
    <dbReference type="KEGG" id="aten:116297233"/>
    <dbReference type="InParanoid" id="A0A6P8I885"/>
    <dbReference type="OrthoDB" id="5952326at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031561282.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38586" checksum="C8B2B3AA74E260E1" modified="2020-12-02" version="1">MAGNISINISTLKKCCIHVGPILWGSSSFNEAAKVSTILAITLNVLTMPMTLFLNALIIFVVWKNPSLQVERVIVLAYLALTDFLVGLICQPFLIAREILQLKSIEGNCGLETVFFLAIGLLKGAEFYQIAVISYERYVAIIHPYLYPTRITVKRLIFATIGLWTLNTVVVLLSFLTLALGVSLYLGALSTILKIFISICMVYWYAKIFTVLRRQKRLIGQQNPNVNMNNPHFQRRHKGAMTAVLLPVCLLFSLIPVFVVMISRRVFGHTFQQSLAWLIVQQWAETVAILTALLNTIIYGLATRGVREKSWEALCFRRDSDEVISQNAFVLNPLHILRHMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8D4</accession>
    <name>A0A6P8I8D4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116300165 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564819.1">
        <property type="nucleotide sequence ID" value="XM_031708959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8D4"/>
    <dbReference type="FunCoup" id="A0A6P8I8D4">
        <property type="interactions" value="1329"/>
    </dbReference>
    <dbReference type="GeneID" id="116300165"/>
    <dbReference type="InParanoid" id="A0A6P8I8D4"/>
    <dbReference type="OrthoDB" id="9936525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THD" evidence="6">
        <location>
            <begin position="95"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564819.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24531" checksum="C102270412DD1E0F" modified="2020-12-02" version="1">MKLTSIVILTALIYYQEKYRSVSAYNQTVTTTTTHAPSMAKPTPSMVCVRNGIDGLDGMNGKDGKDGKDGKEGKQGKPGVCNCTLVQLQRAFSKPSIHLDGKTRKVQRIRAGKALDVWDYQIDTGHISGGMMYSKGILKVPLSGLYTIYSQIYYTSKTYSGRHVIRINNQTVALSEARGLMVAGSAITLGGFHVNKDDEISVAVVYDAEIFTGKWHTFFGAHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I980</accession>
    <name>A0A6P8I980_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">DNA-binding protein SMUBP-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116297175</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561205.1">
        <property type="nucleotide sequence ID" value="XM_031705345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I980"/>
    <dbReference type="FunCoup" id="A0A6P8I980">
        <property type="interactions" value="1162"/>
    </dbReference>
    <dbReference type="GeneID" id="116297175"/>
    <dbReference type="KEGG" id="aten:116297175"/>
    <dbReference type="InParanoid" id="A0A6P8I980"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="19">
        <location>
            <begin position="708"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="18">
        <location>
            <begin position="865"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="599"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="816"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="916"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="919"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031561205.1"/>
        </source>
    </evidence>
    <sequence length="958" mass="107235" checksum="9F38698CD321B04A" modified="2020-12-02" version="1">MADVSTFVDKTLSLLNIERKAEVDEARTLQESSNLNELQKKGVCLLRLRVQSRCTGLYGRYLLTFESSRFGTDGTLAAHRITPGDIVGVSYNSPAGKTQELCSGIVTRVTQTTVVVAFDDAADTDELDDDGPYKLNRLANDVTYKRIKSAMQDLSKYRGGTASHLIDVLFGNSEVGLPLQSDHLDLSKNTEEGGGFFNTSLNESQKAAVRFALSQREIGVIHGPPGTGKTTTVVEIILQAVKKLGMKVLACAPSNVAVDNLVEKLAKSKAKVVRLGHPARLLKSIQQYSLDAILTSSDASAIIRDVRKDIDKALTSSRKSRGAAERKNLRQEIKTLRKELRHREKKAIKEILTGAEVVLATNTSAASDGPLGGVMENHFDLVVIDEAAQALEASCWIPLLRAPRCILSGDHHQLPPTIISHEAAKKGLDVTLMQRVVQLYGDKVVHMLTTQYRNKTTFHFNTSVNSDFSIFQVELLRIRLIPSFPSLEIKSVDGFQGREKEAVVISLVRSNKTGVVGFLAEDRRINVAITRARRHLAVICDSETVSHHSFLKSLIDYMNDNGEVRSAMEYLHGNVITADVSTLESSSIATHVGIRDTHPLVSKETKEGCDVDNNTKKSENMRNPLEPSSLKHNVKSSSKFNSTNSILREKYCLEEKLGIEKDLPDKRSEPSEKTKYTNNKVEHRIKNNFEKKKFANEKRDVVDSSRIPLSKEQLEEQIQGFLKSKMKELVFSNELTSKERFYVHSIAEDMCLEHESKGEGEKRHIVVRKIMKKVEIEKDDDLLSTCQICKKKLPTCNLTLHLLRCEQQQKQRTAAAAMAKNEPFSDTDDVVKKKKKTKKTDKNPQSFSKVKNDEEDLDVMLAKFTHADTRCAFELCKQCITMLGQTCRCCSNTYCLSHHIPEVHGCGDQAKVLSRKSLGKTEPRKPKKLDSTRKAQLQKKLDKKVNEMVDKRKHKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9P2</accession>
    <name>A0A6P8I9P2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116297291 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561360.1">
        <property type="nucleotide sequence ID" value="XM_031705500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9P2"/>
    <dbReference type="GeneID" id="116297291"/>
    <dbReference type="KEGG" id="aten:116297291"/>
    <dbReference type="InParanoid" id="A0A6P8I9P2"/>
    <dbReference type="OrthoDB" id="10288074at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CD59"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Activin_recp"/>
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        <property type="entry name" value="LY6_UPA_recep-like"/>
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    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027729659" evidence="6">
        <location>
            <begin position="25"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="7">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="7">
        <location>
            <begin position="225"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Activin types I and II receptor" evidence="8">
        <location>
            <begin position="366"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
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            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01064"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031561360.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="60053" checksum="B8F653CA4A0F5606" modified="2020-12-02" version="1">MKLYHTVLLLLVLCFGSSNWASHAYSNPFVTNAEEEVDDFKDSAFVDDAEEISAIKQFQTSAARSAFVEDLQTKVEDNDMNSLEHLIAKHNEEKRLQIESLMKRGNILDPGNIGDGETAPTCYSCYGNSLKSCLNSMKEKQCQGAQRCYTVHLISKATGRNTFVKGCINIATCQSDICQTIHNTSKGEFSFCKADCCKGKLCNVENVGTTPRPTEPATPPINGPKCYSCQGADIASCASRMTLKQCLPNYQCADAYLVIKNNGRDLIAKGCIPSGLCGGGLCEKLNNSGRYSQCRSSCCKDDVCNAIPTLPTTKGTTTEQPPTTEETATQAPWNATTEQLANKTTQVPTPRPLPSRPTPKPGGHLCYTCSSETAQECYSNLKVNRCDVGKVCFTGEATQNNGIKMFAKGCMRLEQCATSCKRLSVTTKECKVDCCRGDYCNDFPLTTKRPTSLPDTGCYRILSQVLEVFKKLLETIDTLMKFKEFNLKVAPYYQREINSLMGTINAHAVSVTGDDGPEVRSAATKMRSLRKRAGKVLKKLDKIIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAQ7</accession>
    <name>A0A6P8IAQ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pinopsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116299712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564291.1">
        <property type="nucleotide sequence ID" value="XM_031708431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAQ7"/>
    <dbReference type="GeneID" id="116299712"/>
    <dbReference type="KEGG" id="aten:116299712"/>
    <dbReference type="InParanoid" id="A0A6P8IAQ7"/>
    <dbReference type="OrthoDB" id="5990365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="110"/>
        </location>
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            <end position="151"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="230"/>
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            <end position="267"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004651"/>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031564291.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34784" checksum="1F47D25E809CFCC0" modified="2020-12-02" version="1">MKGKISKTEQVSWTVVFTFEAFFIVLCNFLALCVFAKRKFLLCRSCYLLINLTVADLLVGISAVFSGYEIISLERSEIKSFMTCENKLFDAFATLFLLFTVASLMSLVLIAIERACSIFMPFRHRVAKTRYYNAGIAFIWLISGIPSVSLLPQCESLPINNKLVTLSLLLILVIPSFVILVSSYVAIYIKLRFFPVFQHNNSTQRQIKLCRTLCIATVTSIIAVLPHNIVLTTLELCTSCTLSVNAVLTTKAFIFGNSFINLAIYALKIPEFWNELKKILCNCFNKGERRQSRVVPGMIPLDTLDTGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC53</accession>
    <name>A0A6P8IC53_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Band 4.1-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116298809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563227.1">
        <property type="nucleotide sequence ID" value="XM_031707367.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563228.1">
        <property type="nucleotide sequence ID" value="XM_031707368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298809"/>
    <dbReference type="KEGG" id="aten:116298809"/>
    <dbReference type="OrthoDB" id="6589456at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
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        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF21">
        <property type="entry name" value="PROTEIN 4.1 HOMOLOG"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08736">
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    </dbReference>
    <dbReference type="Pfam" id="PF09380">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="9"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563228.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50693" checksum="638AB2EB86619131" modified="2020-12-02" version="1">MGKPKTYSCTVQVAGLEEDFECSITRKTKGDYLFEKLCDYISLVEKEYFGLRYIDEKDGQFNWLECDKGILSQMRKAPLHFYFAVKFYPDNPTTLREDITRYHFVLQLREDLLKGRLQCSNPIHALLGSYIVQAELGDYTFDNHDHGYLRDFKFLSRQPHEVLNKVEEFHXKHIGMSPADAEFQYLDNVRKLPLYGRDLHQAWDAEGQAVTLGISAWGIEVFHNNRLMQRFIWPKIITISFKSKKFSLTLRAPSDEAQYSATTVCFAFSSRRASKRIWKVCVEHHSFFRLKTPAPVQANSGLFRMGSKFRYCGRTQHQARHNELVETRDPPSFDRVSSKRFSMKVLDSNRRSMLIDDDSRKEKTNKALDHDEDKKEEKRDEEKEVPKEVEQEEEKKPEAPKEAAAPAGPVVASETYVSSEALLESGEGNTSTSAACXVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID89</accession>
    <name>A0A6P8ID89_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116299521</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564042.1">
        <property type="nucleotide sequence ID" value="XM_031708182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID89"/>
    <dbReference type="GeneID" id="116299521"/>
    <dbReference type="KEGG" id="aten:116299521"/>
    <dbReference type="InParanoid" id="A0A6P8ID89"/>
    <dbReference type="OrthoDB" id="5982296at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="AL/BT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="3keto-disac_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027760694" evidence="2">
        <location>
            <begin position="28"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="3-keto-alpha-glucoside-1,2-lyase/3-keto-2-hydroxy-glucal hydratase" evidence="3">
        <location>
            <begin position="219"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564042.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="75915" checksum="B603AD578D2B28E7" modified="2020-12-02" version="1">MKKVFAVFLTISLVLQHVVMLSAHVEAHKAKSNIDFLSKKLHSNLLDLEDTYKKTKEEISKTIEEVVIVRKIQVLLGQLTNGEVPGMQECESGYVLLDFLYKQNILIETKSALPAHYTITVKVNHKALVDQKKAAKNGEDLRVFYHPDKGSLPVEINRLFHNLYTDATTVTFRIQKMISANTVDLKSYALVFGGKFQGKAKAKANPRKVFAFYEDFSRSSLEGWNRVWGEWTVKNESLFGKTGSSPYGNGEVGLYLTQGKEWSDIEVELDLMETGSNVVYPGPFLRVQDPRLQHTTAWWFEYYTDNKNCTIRPCKNNVYGGGIHTCQLPEKLVKNKWFHFKYRLQGEKISQWADGIPIQDATVEPKWMIPKGTIGLGCHSIYSGSPTGCRTYYDNIKVKLLVSSNPKVSPGDVCHFVHRKVFNLGKKERPGNSCKHIYDANLHGKKKSSSKNGVYWIKTALQGHNRQTFCDMNKGGWTLVGKISGRVGNIYNSWLVQNVNTDLLKSPRMSSGKVEYGCLDARLIAVRHSTEIMFSSGENPSGVGKKWVRWQLPQGREYSTWWNHGVGYKRANAAVESPVTVQAWNGGSKVCHQNKYGLMPHPLVGGSYPYASYNKHGNTDTNDYCMAVGVMLKGSTANGWGHNGNGYDSPQSDSDWPNTIYNHQQPYLLVWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDT4</accession>
    <name>A0A6P8IDT4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Galanin receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563740.1">
        <property type="nucleotide sequence ID" value="XM_031707880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDT4"/>
    <dbReference type="GeneID" id="116299250"/>
    <dbReference type="KEGG" id="aten:116299250"/>
    <dbReference type="InParanoid" id="A0A6P8IDT4"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000664">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001556">
        <property type="entry name" value="Bombsn_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00358">
        <property type="entry name" value="BOMBESINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563740.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="45113" checksum="EB9466D8BAD2861E" modified="2020-12-02" version="1">MNFTTDSYQDQLSSQVPEPYASRIFRLVLYAIVFVLTVGGNVLVCTVVINNRKLRSMQRFYYGYFLMNLAFADLAVALLCIPFTVVYYETGNWPFSAFMCKLVPTLQVTSVSASIFTLTVMTYERYQAIVQPLKAQIPKKKVLTMLGMAWIFAFVSASPEIFAYQFHDNASQKFQCRELWPHQKYRQSYTMFLFVCTYLFPLMVIFPTYIKMMSTLKKSHSFNNTDKKLRWKSLRVLIAVVIIFATSYLPQHILFLAMDFGSGLSFPYFEITLKYCYLMVWVSSCSNPIIYGALDDYFRDKYARILRHCVAVKRSTKKLSRATISYSQGTLNPQKSSPTEQTLEKERIPRDQSGRLEEISSPQSNILESYSANNDKNDFKQVTPLLGCSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG90</accession>
    <name>A0A6P8IG90_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melanocortin receptor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300939</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565777.1">
        <property type="nucleotide sequence ID" value="XM_031709917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG90"/>
    <dbReference type="FunCoup" id="A0A6P8IG90">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="GeneID" id="116300939"/>
    <dbReference type="KEGG" id="aten:116300939"/>
    <dbReference type="InParanoid" id="A0A6P8IG90"/>
    <dbReference type="OrthoDB" id="5983114at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
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</entry>
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    <sequence length="574" mass="64944" checksum="8E717915E774E025" modified="2020-12-02" version="1">MSSSNSSLQYSASDDTVHCVSHTFKLVSTIAICFSGCFMNGSILLVLLRKPQRSIVNTILFHLALSDMVVFLANGPYLFLSYFDQKLAFSSLLCQVGAFIGRFTTAVSMHLLTVMSLSRFYSLLKPLEYRVRVTATKAKRVCIGAWVITFWQSLTPVLGWGKYTVIKGQCYCALDSSEHMSNWFAHLLLAFAIPLTLNAWIFARTLRLVNFKIRDAKKGRISGGPEKKETSLLNKGERECTSSVDNERNTGNVLPNKYASVNNRNLGNMDKGTRAFEEEGATNNPDDIKIKARINEHQYKSEEMAVVIQGFVAIVNEENKKEPDEFVNQSIEDEGATNNPDDIKIKARINEQQHKSDEMAVVIQDFVAMANEENKKKPDEFVNQSFEDEGATNNPDDIEITARVNEQKYESIEMPGVVIQGIEQEKQTELSTTDDKDHEISVSSVEKSSCHHENKRQLNRKQIQQEEGSNKMKKKQHNENKTCKLVELKKELKANVIISLLFTAYVIGCGPTYVVWTWFALDPKSVPRTAFLSFRFLAGIQSVINPFIYGFMNSEIRADVLALWKNARCVFRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGK0</accession>
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        <submittedName>
            <fullName evidence="11">Deleted in lung and esophageal cancer protein 1-like</fullName>
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        <name evidence="11" type="primary">LOC116300996</name>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <sequence length="1642" mass="182214" checksum="20855762087FFD3D" modified="2020-12-02" version="1">MSGSKGIEMEPPMHLQRPSSARSQDISHVLASVFREVFTRDVVGEQTVKHLTTSRSGEEGYHDKYVRQLEEIQEKREKCHREADMLEAHIMQAQASAMAADERDLQKALGQCEQYPNLGLPPGQSNLRYCLDTQLLRKFNLIVPEDFTSNGQTEAKPPQADEIPSYARFTTSSHQRYRKTPPLTDYLDDRVTSSLGYPFTVASKPATAERKTREISTPATTHTKISKAIWKNSMKPSQRQIEREDLKKLKSKAEYKRNPRFVPPLTADLIQEKSKAKEVKESATGSSQVVFIATPSPVVFSEYKVGEVYELMVELKNVTSSSRQIRIVPPSTKYFSIGLGRFPGESGVVAPGMSCVYPIRFSPDFLADYDDTIKVKTQIDPPMVISLQGRRPPPQLSLSSVLDCGHTLVGGKKTVHFTCTNQGGEGQFFLMSKSDWPTTYSKWSLDNPGFLDIAPFEVKPAMFELKSGETIDLEVTFCPSAAKFFKKEMIMVCDNCHIKVLTVEGTGQTAGIEFVSISGGTSKHDIGELKDVSSQFLVRFDDQNPKTHTAKELTIKNTTNVALPFRWKLFKPFFPCQQTDELGVSTSQQLSSRVHRTADAQGVFSIAPNMGTLPPYENVHFSLEYLPKEIGSFHSVAHLVLEEIPVHGQENATSVSRDVTAIEVEVKANSQPFHVQVNPGTLTIPGTLLMATSNTYKFKAHNHSVSDVQVEWQDMSTDECTINIQPQSTVIAANQPREFSVSITSHVPGVLDQTLFCHVDYSSSPVYLHVRASFEGPEVTMDTLDLDFGLVRLGESASREISVTNKSNITAEWSMQECVDCISDGKDQKCNNSSSSLTSEFDFVPTTGSLGAGESAVVSVTFRPTHCRRVRTVFQCQEKIGKTNYLSVFSEVQSPLVCLLSSSLYLENVYLDVPVSRTITLQNQTLLTSEFCWNEIICNKDSDYSVTFEPSRGVLQPREALDVRVTLTGHRKGLVESLTTSCHVTGMDKPIWLGISADVKGLNVTFEMPKILDHHTPDEIKTANIDSSSTNMIEFGKMFLGEERKATVVMTNTTAIRARFSVHVNHFTAAKPPTPPEGQPQKRDGRRPQGLLTRTPNIANPLSKTATKAYADQVSACLRDGRGAAFVPSPSSGELLPFGYQVIEITAYNDMWGDYRDLLICMVEGLDPVYIPIQMSVLGCPLNFQMMKDQSPVLRFGTHVSGATPVTRSLRVNNTSPFDIRLDWSTLNIEDDDDQLLDMLVSYGQALPVFNDKGEELLPPPPLCDFPCFMPPFIQVKLLEHEGIRSDEPFQVLPSQQVIPAKGHANMTVTFKPNTTNPAGQTCTSFAAGYMSLDGPNIDIPGRVTRSQGMDMTPFRLDITATILPALLSVEMEEDEGCDFIATASNLLNGDFTKIHRFILSNTSETPLALNIAVDAPFKVMSSEPPPSAKSTRSQANGLTIIKPGKNIQVKIGFCLTKELLSRVDELPVNKEQEDGSLLTVKENGDRKLFFNRKLVVEFSNKSTQVIPLTASVSVPTLRLSKQELDFGTCLVGQEKEMQVVLTNPTESSSEWVAVKDPRCPQVSRDVFTVTPSNGLLEAYVNHVAKNKVLIRVTFVARHNVEYECVLIFKGRLHEEEQHVVLKGRGSYDGRHENLVNVVTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHA3</accession>
    <name>A0A6P8IHA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116301264</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116301264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566156.1">
        <property type="nucleotide sequence ID" value="XM_031710296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHA3"/>
    <dbReference type="GeneID" id="116301264"/>
    <dbReference type="KEGG" id="aten:116301264"/>
    <dbReference type="InParanoid" id="A0A6P8IHA3"/>
    <dbReference type="OrthoDB" id="5917911at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="200"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031566156.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35053" checksum="95D45D0BF09D83BF" modified="2020-12-02" version="1">MVGAYGLTCVFTLYILIAVLFIVDDGAEGLTLRVPHGKLEALLGRKCLNLLFREPCVDNQHCNISLEVKLESKTGQMTSSTSKSIESSQIMKINSTSMYLLCMFDSSAGENVSCCNDISHSPGINITNGVEVGLSHYQEISFDLKACNESCLTLLKFFNAFLPWHDPCYFGKPCQNLGTCQPAFNSYTCLCRGNWNGTNCTIPKDMTYNAGQCLNYLSSADVKLYMKTVEECRSACLNQFSPRCKAFQFKQIMSGNYGNCTLRNSNSLEQKVQSCDMDLYEFTNLLIPPTPESHSAPTAVATVTLNLLLAFLAFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHS5</accession>
    <name>A0A6P8IHS5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pituitary tumor-transforming gene 1 protein-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116301450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566371.1">
        <property type="nucleotide sequence ID" value="XM_031710511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301450"/>
    <dbReference type="KEGG" id="aten:116301450"/>
    <dbReference type="InParanoid" id="A0A6P8IHS5"/>
    <dbReference type="OrthoDB" id="5829916at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052304">
        <property type="entry name" value="PTTG1IP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191:SF3">
        <property type="entry name" value="PITUITARY TUMOR-TRANSFORMING GENE PROTEIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15191">
        <property type="entry name" value="PROTEIN CBG20567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028415031" evidence="3">
        <location>
            <begin position="26"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031566371.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21181" checksum="8572746F19C22CB4" modified="2020-12-02" version="1">MAIKNYTSFLFVSLVVLGIFLGASAQKASTTVAPKTSNTSTSTSTPATTKPXMTCEQRNSSCGSCTDDKKCXWCSSDSSCKDYPTSKIIPRDCKGNKWYWKQCLAPGYVLIIVIPSLCGFILLTLGCCIYCCCCRSRGNKEDREETRIRRRREEASERSAQRRADRQKRSDAIRQKYGLLNNEDDNEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIK0</accession>
    <name>A0A6P8IIK0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MICOS complex subunit MIC19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566363.1">
        <property type="nucleotide sequence ID" value="XM_031710503.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IIK0">
        <property type="interactions" value="819"/>
    </dbReference>
    <dbReference type="GeneID" id="116301445"/>
    <dbReference type="KEGG" id="aten:116301445"/>
    <dbReference type="InParanoid" id="A0A6P8IIK0"/>
    <dbReference type="OrthoDB" id="70030at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052632">
        <property type="entry name" value="MICOS_subunit_Mic19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21588:SF18">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566363.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23700" checksum="91605769337F88E9" modified="2020-12-02" version="1">MGSSESTRKVTLEKDTDGDSSGIIKVSERVVQRLRGKKDLPLNLSEEVTPEEINKLWKELQHEKTHLEIQKKRLEDLLQRAFEEGRGQSLLNDSSEXVDVAEVQKLKDDMVVRENELLNEIETLKQKNAHIDAVSDEQYNAAFEEIKDKFRQIERPKVCQSIQQLALDCYQDNPKQTLRCSQYVKDFEKCVQQSRLENLQDIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIM7</accession>
    <name>A0A6P8IIM7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane and coiled-coil domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116301650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566599.1">
        <property type="nucleotide sequence ID" value="XM_031710739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIM7"/>
    <dbReference type="FunCoup" id="A0A6P8IIM7">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="GeneID" id="116301650"/>
    <dbReference type="KEGG" id="aten:116301650"/>
    <dbReference type="InParanoid" id="A0A6P8IIM7"/>
    <dbReference type="OrthoDB" id="1654420at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045158">
        <property type="entry name" value="KEA4/5/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254">
        <property type="entry name" value="POTASSIUM/PROTON ANTIPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254:SF14">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027650891" evidence="11">
        <location>
            <begin position="22"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="265"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566599.1"/>
        </source>
    </evidence>
    <sequence length="684" mass="75463" checksum="6988C6596E91B5E5" modified="2020-12-02" version="1">MMLKNAGFLMILLSAILMCRSSELDFDSRWNSKSCSAIYQLFHTKEQVIQKLKQVLDVEKEKKLLSHAQVRAIVIYQSELNDTERAVLEAMGGLRKLLHEDYKSVVKIKEAIKQRLNSFKDIALRQEDQYNAISEAEKELAAENKHQKNSSSRIGKLIEGILSDVSFAADKLEKKLSDNTFEKTRKSKGASIEAVVRLKEQEEGESEEELGPTKSPEEEEEDKKDGMSILVDSQSNQFVLSKSKDATTPHEDVHLIKDIIWIIILSFFGACACMVVQLPTMFGFVLSGMVLGPTGINVIKSVVQVETLGEFGVFFILFCVGLEFSPERIRKVWKISLGGSSLIMVLTIVFGMFGGMCLGILPQQSAFVAACLSLSSTPLIVKFLGSKHGENSNKEHTNGDHDYSSSLLGILVMQDVYLGLIVAILPALSGHIVSPSNGNNGVVHHLLHGQGPSNGTSAVEGFVNTSWIVLEVFGSMVGLFIFCIFIARYVLASFFRFLHRMGTVELLFLGTVAIAFGMLLISEHLGISMELGCFVAGVVISANGEQLVKQVVHLVEPIKDFLSCLFFASIGLHVFPSFVLSELSVTLTLTFGVVVLKFLVGVFVLRLFLPNSNNSKYIVAAGLAQVSEFSFVLGSRARRFHLISREVYLLILSVTTLSLLFAPLVWRVSLWRFGTKPGKSNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL17</accession>
    <name>A0A6P8IL17_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="2">1.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031567462.1">
        <property type="nucleotide sequence ID" value="XM_031711602.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IL17">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="GeneID" id="116302321"/>
    <dbReference type="KEGG" id="aten:116302321"/>
    <dbReference type="InParanoid" id="A0A6P8IL17"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF5">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031567462.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38496" checksum="68660195E6CC7688" modified="2020-12-02" version="1">MAEEVYRVVFKSRPGKTNPPSVENFAYEKAEPITCKDGEIIAKTLYLSVDPYMRSRMNDEDPNAKSYITKWDLGKAPTGGGVGVVVESKNEKYKKGDMVKSFKWPWQNYALLNAEDEQLQKVEHQLIKEKPSLALGLCGLTGLTSLVGIQVKGHLVAGSNQTVIVSGAAGACGVAAGQIAKLLGSGKVVGICGTDEKCAYIKELGFDEAINYKTTKDMSTALKTCCPQGVDMYFDNVGGIISEEVIRLMNKDSHIVLCGQISQYNKDLPYPPPLSPEVQEIATKQNVTRXRFLILNYPEQIPGALKQLVTWVQEGKLKSRETVEVGLENTAKAFVSMMIGGNIGKQVVKVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMD2</accession>
    <name>A0A6P8IMD2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">LIM/homeobox protein Lhx9-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116302396</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567543.1">
        <property type="nucleotide sequence ID" value="XM_031711683.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IMD2">
        <property type="interactions" value="885"/>
    </dbReference>
    <dbReference type="GeneID" id="116302396"/>
    <dbReference type="KEGG" id="aten:116302396"/>
    <dbReference type="InParanoid" id="A0A6P8IMD2"/>
    <dbReference type="OrthoDB" id="9990008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09369">
        <property type="entry name" value="LIM1_Lhx2_Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000033">
        <property type="entry name" value="LIM/homeobox protein Lhx9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="155"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031567543.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47271" checksum="F4D2CD814FFE9E2E" modified="2020-12-02" version="1">MSTKGSVSKQTENERTKPKQLKARICSSQIKWNWRSFQMKKRKYILHMKRHVREEKTCTKILLQDMQYLLKSSTDKEVLVVEMAADIVLLIKRMFHSAKGKQNLTLPFTFSKSKKYILDEVALGFKKVGLKIGGLVSSQATMPSAGQMNSLDKNSICAGCGLRIIERFYLMAVDRAWHIDCLKCSECDLRLDNELTCFSKDGLILCRDDYYKRFSVQKCSACGQGITSKELVMRAREHVYHVGCFACDRCKRMLATGEYFGMRGMRIYCKEDYEELLREESRSGKTSSSSKGRPRKRRLASTIESVSALAGFTLGARPEDLNGVTSDGRPKRVRTSFKHHQLRAMKAYFAINHNPDAKDLKQLSQKTGLTKRVLQVWFQNARAKFRRTVCNSQSPMSPSCEQLTXTSTIVETPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMP2</accession>
    <name>A0A6P8IMP2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567643.1">
        <property type="nucleotide sequence ID" value="XM_031711783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302483"/>
    <dbReference type="KEGG" id="aten:116302483"/>
    <dbReference type="InParanoid" id="A0A6P8IMP2"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2834"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2875"/>
            <end position="3012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="476"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="651"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="735"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2837"/>
            <end position="2849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2891"/>
            <end position="2903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2947"/>
            <end position="2965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2980"/>
            <end position="3012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567643.1"/>
        </source>
    </evidence>
    <sequence length="3012" mass="348704" checksum="CDE5E19D9DC18122" modified="2020-12-02" version="1">MTEENLEPKMNGGDPDHDITSKPAVTVRKHYRSAPIRSSQFYYSDLEADKRLVKARDSLSGIGDTAYKHFKDVLDSLADKHSIEIRNLQFQIEELLRQKNSLDDKCRTSKRESRKFQEENASSKRLIVERDWRLEAQTKEMESKDRVIAQLRKDKLTLEREIDDLKHELNSHQAKFDIRTLQGHGDDEYTVTRDEMLKVEASYNHMSAEKEELHNDYIELQAKLEGLLSENERLQKELETQKKTNQLKTAKYEAQIDNLNKQKTELKDKVEKLRLELKKLKELYGNSQRDLIESQNKADARKEELISKNNQIGKMENRIISLEGKVDGLRQELSKSQTALEISQKQKENFQHELVAVQKSNDDLQDALEGMKTERDSLQNQVFLLQRKLRSAEDAYEKSQNKITNLLQNERTLKQKISDLEAELAASRSRNMQLENELELAKSRPVESKLDVITIENVQAVESGPPDGFGFDSEELEQANQDKMALTQKVTELESLIHRLEYENAELQNNYSHAKGQVTKLECQVESFGRQKSEILAELENEKGKYAKLKNELTMLQQKLSETEKMLEQKTKECAKKTKQIEELKAKIADLQKALDDRNEEMYKLEGKLEALILENEKLHEESLDHKRALGDLESDHKSAIDERNNAHYELKSHTRKVSELESKLAESEKARNDLHAQVLALQQKLNVLEDELDNTHKERAVYESEANDLSMSSNKLRDDAAISKKQAMEYQGIIDSLKKEIGDKDQTIDHLRNKVRDLTEDIDDCKADLSEAQAQCDAKEEDIKTFERKCDEKDSEIERLNAILDRTTKERNDAEVQVAGLLEKLKNLEGVRKEFKGEKAPQSIDINIFKVQELEKDLSTLRQKVYKLEKDNDALRKDNALLDSEIKDKNDKIDALMRELEGKDEDSTEIRKELINLKKKCATLEKENDELADDKSELAELLADLRPKVSKLQDNVDLLTKQRDDLKNSLGDANRTIIDLKEDKNKSEMKASHEEKANVSLGKIVKKHEGSLEDLSSKLRAAESDLESLRRELVSANAKNDSLVQEKKDSAKKLTDARNRIAELEAAIHDLKDVRELLEQDISSLTYKLSNLETKVSNLEKEKAYYQHESEELQTKNRKMKNDLVQAQNQLKDKDRLCEDLTAELKDKEASNNALKRQKKALEDEINSLRKQLEASKHANDINKEKIRELLAQLERASLNAVTPVSVSVVESSIPMSFEDNLQSAPDDGRVYELEALLKAGEDRENALRKELENYRGKFNKSEAENKHIHEQLVDLQHENAALQRKLREAELALSRLNRENDDLKKDLAEKTSKLSAIETQAESDEAEIRSLKNQLRNVSDRVNKHQDELLSMDQELVEHRLAVDKHNQENNHRESLIKKLKAAKEYLEDQVESLKASLETARDSNDDLKAEQAKMLEDIMSLKNTINQLKAANQKLASERERAVEDAKDAFDKIKDLEYRLQEAIAKRKETEEENDDLEAEIRKLKDELAESKRLYNNLQDKLHALEDELDKNEKDIDDLRDNKKALESEIADLKAQLASMDKLPVIQPLQVEQVQATYESNPNFDFGDADEIKRLQDENQDLKRRLKELEADHRLLDDKKRSLNDQLVDSHGHKSKLEASLDHTNSRNLALEKELEAIKRDYKPLEDKYDEAVRELDILKKSADDANSRLSDVEIQLDTESNKRKQLQGELEDALEDIQVKEEELNKARRKIQEYMKILENGGQDSNVKDELIENLKKEIETQEREIRKLRENVLSANNALDKSHAKRDELDKALFVAKQHLADDEMTIRAKIQDNDFLNEHLQDAQERIVELERELQNAKKNNAQMRSDLDDAKIELRKAKEEKNMLQQKIAELQALIEALKKDLMDRDSIIDQLRSGSNNVGAEISALKKKVAKYRDDYQKSQDEVARLQLLLRERADNVTPRGNALVAYKNDNDKLKSDILTLQSTISDLKNNYQNAQREIEKLQLELMTASQKFHQAEARNEALEAERDRLKKEHAAHLKEISNLKIQLDSLRHENNKLKNDLAILQKKYDGLQQQLANADARKAKKGREVVTQKKIGELESSFQSALREKEDAKSDLFILKKKIGKLENEIGEYQREKDSLEHSLDCRDNRIAELEDSLKSAQDNHKADKNELLQWRKKYAAIEQELKSLQNMITRLQNQNKLSEQKIDDLTDDLAEANNRIEVLEQALADHDGPDSKYKDYLVAESKISELEAALKAALEGKAQAEKENQKLKSQVWDLEDDVKMIQLKLDQLQNLLDETNKLNDRLKKELADLKRHSYDSTQNYDAVNKELSDHKYKMELSEKERDDLENEINTLRRELSDLRAQKEKVNVEKSDLKVQLHKLQTQYDSLNAENEDLREENESLRRDLQQARDEIMRLKSQLENQVAPIQVATVEAVESEPFDFDELDGAKRDRDQLQLEKDAAEQRLKDFEQDLHEKHLQKVKAEESLNDLKKHLTKLEMDNKNLETAKDKALYELDLANKKFIEQRTENELLKQEKESLVIEINDLKQDMAQKDRELQAIIKKRADLEKQLAKIDQKDGSADTLRRKYQDRENELQRELVDVQRKLADADYRLKSAEDKTNEAEDSKADVERRNAMLRDEMINLQATISKLEVNLKKEQDTVQDQEDEIKELMLKLGDTANTSRAGGRNLSEIEADLDALKKRNRKLEDQNAFKDKEIARLQEQLEEYRDRLEKGTGDLEIHLKNMGDKSEIYRKDALDKANHIEKLRAEKLQDEIDIQNLQAELESLKKELAENENDLGIKESNIGELHEEKINLENKIIELTNNYKMSLAELENDNEIRNNKIKSLEDLLKKYEKQIQELRESQATTDPSSSTTLIFDVDRRTRVPSRYVSYAENQLQPEKRSLYKLSSEGSGIDRPSPERNGSVKEDPIEMTVSKNPKVQSPPRRTSGRIREGIEVPFDDEQYQRKRNGPRYSKDRVDENIEASEAKTAESEISFDDDAPMSSTRYEDRKQSEDRNPRNDRRSSGRSSKDKEQCKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP57</accession>
    <name>A0A6P8IP57_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116303256</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 18"/>
    <dbReference type="RefSeq" id="XP_031568627.1">
        <property type="nucleotide sequence ID" value="XM_031712767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP57"/>
    <dbReference type="FunCoup" id="A0A6P8IP57">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="GeneID" id="116303256"/>
    <dbReference type="KEGG" id="aten:116303256"/>
    <dbReference type="InParanoid" id="A0A6P8IP57"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000029">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
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        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
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        <property type="entry name" value="2Fe2S_fd_BS"/>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
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        <property type="entry name" value="Helical_ferredxn"/>
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        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
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        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
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        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
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        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
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    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="17 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 18" id="KW-0408">Iron</keyword>
    <keyword evidence="14 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031568627.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32312" checksum="9DEE292477FD496E" modified="2020-12-02" version="1">MAAISGLRAIRSVQLRPAMALMKFQTRDATSAATADEPRNKTFSIYRWNPDKPGDKPTMQDYQVNLNDCGPMVLDALIKIKNEIDPTLTFRRSCREGICGSCAMNIGGSNTLACIQRIDPRTDKKTKIYPLPHMYVVKDLVPDMQNFYDQYTSIKPYLMKKEKVEYGKEQYLQSIADRKKLDGLYECIMCACCSTSCPSYWWNGDKYLGPAVLQQAYRWILDSRDDYAEERLAELGSDNYKVYRCHTIMNCTKACPKGLNPGQSIAEIKKMIATLKSNKKAAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQB3</accession>
    <name>A0A6P8IQB3_ACTTE</name>
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        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569261.1">
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    <dbReference type="GeneID" id="116303799"/>
    <dbReference type="KEGG" id="aten:116303799"/>
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    <dbReference type="OrthoDB" id="410267at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="195"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="18"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031569261.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="52806" checksum="5373566F54F47D05" modified="2020-12-02" version="1">MSCWPTTTRPPHPKDGPWAWLVLSYCFLNGVVIGGIAFGYGVILPVLMDALQENRERTALVGSLALGAGLFLCVVSAKLCEKFNCRFVNGVGLISYVMGFTLSSLCNSIYPLYITYSLLNGFAGSCTYTSNFILVRQYFKKRYSLAMGIVTAGAGIGMLSVGPLVQYLTDTLGWKNTFRVFAGIFGAFIPLTIVLDPNVESCEEVPIETVMQENSIEKDIKIKPRKIVLGFLDLSVWTFPEFTISVVAIFIGSWGHYTPLIHMIKYSEEVGISPTKSSTLLVFVGIATIVSRLVSGRLCDVSFIKPRYVHQAGIILSGISTILLTFGVNYTHLIIFSVFFGIADGAFRLTMNILFMNTVDIPRKPSAFGQANMIISFSNAAGPAIAGMMADKSGSYTSAFYMAGSVSIVAGAIFFLHLCFFKEHNNKRELDISNATDHPLACVGPASSEAEEASLHTMITILDDLHKPRTPLNTKKPSSAEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQR6</accession>
    <name>A0A6P8IQR6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116303242 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303242</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568613.1">
        <property type="nucleotide sequence ID" value="XM_031712753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQR6"/>
    <dbReference type="GeneID" id="116303242"/>
    <dbReference type="KEGG" id="aten:116303242"/>
    <dbReference type="InParanoid" id="A0A6P8IQR6"/>
    <dbReference type="OrthoDB" id="5953876at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027813939" evidence="9">
        <location>
            <begin position="30"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
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            <end position="432"/>
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            <begin position="177"/>
            <end position="259"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568613.1"/>
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    <sequence length="496" mass="56664" checksum="DD21A86A3A352D3C" modified="2020-12-02" version="1">MKARRSPFLATVLLSLMTVKFCSLGLTNASICHDLEVNISDSSCQGQVQCPACVKISWFERKPYVYRQKNKTIGILPEVLDLMLSKCCGNHTPSCWHLHHYEPISNPSRLLFEVSNAHIVYPVIVDSQDPLENPANMIGLIPPSSISFVVLKDKRESFPKKLLMSVFEAWPVLILTLLLSILAGIVLWLAEIRANPEEFPRTFIGGAWEGFWWAFVSMTTVGYGDRAPRSFLGRVFAVMWILLGICIVSIFTATLTTSLTTISLDTKRSVTGSKIGVLQRSIELSMAMQQQADITVYSSIEEIRTALDDKQISGAFLDKYFINFYEELFPQNIFKVDQVITQNKMQYGVVVNHTAIDKCFRKLLHQDRFIVYNYIKNELHRTLKIENNKVAIRNSQSIFDPTGDLFYPSLYSCVTLVIVIFLIGLVAEFAYFKPSRCLQKKHTYDLEDGMAMEDIKDSEVIEYKELENEMVEEMRAIFQKYREKMAESYSTKTNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISA5</accession>
    <name>A0A6P8ISA5_ACTTE</name>
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        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116304459</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Actinia</taxon>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570056.1">
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    <dbReference type="InParanoid" id="A0A6P8ISA5"/>
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
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    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
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    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="56"/>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_031570056.1"/>
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    </evidence>
    <sequence length="522" mass="58296" checksum="C54348138855FD4A" modified="2020-12-02" version="1">MGEKDNNSSSSSIEFDDVFQLVNSFGRYQKAVYFGSCILVLLMAFPFGMLVFGFAAPSFQCNTPNITCPQKTCCDNCTSYSFDKAFTSTVTEWHLICGRASLNAAIQTSMYVGMLFGDLICGRLSDTFGRKKCIFIYNGIMVIFGFASSFSNSVPLMAVLWFVMGIGLTGLVISQYIYFMEIVGPKYRTMAGNVYELFWAVGFFISTLLAYFTRDWRNLCMISTAPGALLYLFWRIFPESPRWLVAHDHLEEANFILLKYGGRKNQAIDEERLKNVIARVRQTQRKKVFDLQIFCRTPKIRKWSAALGYNWFASTFLNTALFLYVSNLSGNIYLNFTILQVITALKQPILWIVLKTFGRRIPHAMVMFLIGILCLLLLAIPDKYHTIKTGLFMTASGITYCLWTTTFMITCEIYPTVVRNTAQATGSCIGRIGAIAAPFVAMLGRTPGTGLTVPMVVFAVISLTAGAISLFVPETLFTPMHQTIEEAEAATDDYGIPCCGKPGNKSSKTEVGLQQSLMDTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVM5</accession>
    <name>A0A6P8IVM5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Stabilin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116305391</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="15">Tentacle</tissue>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
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    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
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        <property type="entry name" value="NELL2-like_EGF"/>
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        <property type="entry name" value="INTEGRIN BETA-LIKE PROTEIN E"/>
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    </dbReference>
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        <property type="entry name" value="STABILIN"/>
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        <property type="entry name" value="Fasciclin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="1"/>
            <end position="23"/>
        </location>
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            <begin position="1400"/>
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    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1419"/>
            <end position="1428"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031571154.1"/>
        </source>
    </evidence>
    <sequence length="1687" mass="182408" checksum="2165734B09239BC4" modified="2020-12-02" version="1">MNFSRVLLLVIVGSWSLVRKVSATNRCDVYRYVRYWSRCEECSINERLRCLPPYVHTSSGIGVRGCSLRIYFGSIIGTVTVAGCKHTCDKKELVKECCSGHWGSDCQACPGDPVCSSAGKCFDKVKGNGTCACKDGFRGTACELCTNTTMFGLNCNQTCGCQRGVCQNTVNSSGECKPYSCQIGYTGANCDIRLPACDQSSIRCGAKADCFKINGTDTCVCEPGYSGNGSICLAINPCDGNSHGCHRNANCIYTGPGKHRCECGQGYRGDGIVCVVIDPCQTNNGGCGPDNTTACNFLAPGQSNCTCLPGFVNKTNAVGCTMLDLCDDGNRGGCDVNADCFMSRPGEKRCSCKQGFRGNGTVCYGNIAKRAVQLNTNGPPGVQRLLNYAISMFTHSLARPLADTGPFTVFMAIDTAIGSLSSSQRQMLLSNNTDFISHVVRLHVVAADLSIFALNKTKNITTLQGTNAMFSIENGNKYYSLAGSATKARIIASDFLAGNGIIHIVDKVLWYPGNYTLTHTQTLLEIIQRQKKYEQFSRLLELSGVTSYLTGVRGVTLLIPDNSPFLQLDNITLSYLTTTEEGKIKLRSLLKNHVIQSQFGLQVTDLMSLLRVTSIEGESITVQRTPQGAIVFGGKSQILESNILARDGIIHRVSGLLVPDDIQPLLPNYEYTYQNTSAKSVCYRCDTIPGFPNKGCPGGYIPTTKFVSCVFSLSTPRGRYSFKGCKVSDCIKTTKMKDCSRGFYGSTCRPCPGPIGKPCNLHGRCEDKMAGNGMCTCQSSFIGTACEQCANIKMFGPSCNDTCTCVHGLCDSGIAGNGTCKPNSCKLGYHGNNCDITDKPCSGLSSRRCHIHAHCVNENGADICKCNPGYEGSGEFCSVIDPCTKPNRGGCHKDASCIMTGPGTNNCTCDRGXRGDGVVCVVVDPCKEGAQLSCHLHAGCRFTGPGQSSCVCKSGYTGSGRDCTEINNCLVSNGGCSPKAKCSRVGPGQHNCTCFYGYIGNGYACLGSVAKVIEDDSRLTSLYKFIKKAHLEYFLSMEEMNFTVFAPSNEALNSLDPGDSVYWSQSTDRLVYLIRHHLANISYSSRTLINLTSLLVMNGLSLNITQKNNVVILNDGARITQADIGAANGMVHIIDKVLVPQRLPSEPVLSNVSQVLANLKEFSDLNQFLKNTPLASELENCVGCTIFAPVNSALKNFRLVQHKNITLDVLKYHVILKYLSPGHYYNGQQFSTKLGQNYLVKLTKPSAGEFAINGIPFDSGIRTKFSIIYKLPQVLEPTKSRCDIYSTIYGQTQCRWCPFQLACPSPWTKVKTASCYFWGFLRGCMSICKKVRKVPKCCSGFWGPDCQACPGNVKAACFGNGKCSEGIAGNGHCTCNASFTGIACEKCLPYRYGKTCSSTCACVHGRCNEGIGGDGSCKCEHGWKGPRCNTSANYKNCLPVQCNTHATCRESNGRHVCECDFRYIGNGTYCREVHACDIYSGGCHSKATCSPHPDDPSRALCTCKEGYTGDGRFCSGIDLCQTNNGGCHVNATCSSTGPGKRSCHCLKGFLGDGITCKSDNPCLENHGECSLRARCTQTGPGQRNCTCGPNFVGNGVTCIGSSMEILDIDPELSKLKDLYETYKLDKLLQSNTPTSILAPTNKAIKQIQQGRRKVSLHSICVCLFQDEKSANTVKILFLLKQLHRSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX27</accession>
    <name>A0A6P8IX27_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116304858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116304858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570505.1">
        <property type="nucleotide sequence ID" value="XM_031714645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IX27"/>
    <dbReference type="GeneID" id="116304858"/>
    <dbReference type="KEGG" id="aten:116304858"/>
    <dbReference type="InParanoid" id="A0A6P8IX27"/>
    <dbReference type="OrthoDB" id="5972917at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="250"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570505.1"/>
        </source>
    </evidence>
    <sequence length="653" mass="72233" checksum="E7AF7CC176239819" modified="2020-12-02" version="1">MLPKSKQSEFSKICRDLVNERWTISGKSSLHYGLECNENRDGLPTGSPAKKARQCNYKLLGNALKTGISDGQYRREPLTLQQLQVSEGGDPSYERKHPASQRPLPVPYQDENGLLAGATTITQDVPLAREFEKRKNTKVLRMERESNSVNFGFKILGDLFTEREIVVREVDKQSIAERAGLRARDRITRINDMSRERARKSDIVHLIKSENVLKLTVMSTKHFKEAQDIDVEERAVAIETTEVHDYNTKKVAIYTNEDGWMGCSIRGGMDYRCKVHIISVADGSPAESAGLKQGDIITEVNGISLKGCTHVQAVNLILTASPPILFTIEHYDNRHDGGVLQKPESQNANNLPHTPLRINNCRPRRLEQGASDIAPCLSPLPLPPPLPGCWYQNDSPSVGASGVVSSPSALPLNTLHLDGTPPPPYTAEVPQMHKVIQMGGNARENRNNSNHGLLLPMESDMPYQHSSRTLQNEELTTEQSRESERDAVRHSTHKGNDVSSLSKNASCLLDIETSSTGNTYIVLQDAEINDASGNQAESNSEKEGANTKPNSQSSLLEAIRNFNTGSLKTAKEKNTLHTPGKLFPSSKANDSLKADTEHVIRNGSSVSNEYQAVESSEADLRNIINQALKKRRADILDSSQESVNESYCSEWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXT6</accession>
    <name>A0A6P8IXT6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116306030</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031571917.1">
        <property type="nucleotide sequence ID" value="XM_031716057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306030"/>
    <dbReference type="KEGG" id="aten:116306030"/>
    <dbReference type="InParanoid" id="A0A6P8IXT6"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF111">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027551521" evidence="1">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="44"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571917.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26176" checksum="F202A361FFC1C83D" modified="2020-12-02" version="1">MIWPGVIASRLLLNLRFGFLISNGFNSSATNKARVVAAVFVSAAQAATRKHKSPRTIEVVXNDLTKEKVDAIVNAANSWLKHGGGVAGAIVRSGGEIIQQESDELVSKNGPLPTGDVAVTTAGNLPCKVIIHAVGPVWRGGDANEEKDLQSALLNSLEECHRRNLTSVAVPAISSGIFGFPKDLCAKILFSVAIDFLSSKEETTLTCIRFTNFDKPTVEAFKDHAETLINKPGLKVEIYPQSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYK7</accession>
    <name>A0A6P8IYK7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Muscle M-line assembly protein unc-89-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116305184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570900.1">
        <property type="nucleotide sequence ID" value="XM_031715040.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116305184"/>
    <dbReference type="InParanoid" id="A0A6P8IYK7"/>
    <dbReference type="OrthoDB" id="9976063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20831">
        <property type="entry name" value="C1_dGM13116p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039934">
        <property type="entry name" value="C2CD2/C2CD2L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21119:SF5">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="273"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="888"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="8">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570900.1"/>
        </source>
    </evidence>
    <sequence length="958" mass="108223" checksum="7DCE3229C7E5F211" modified="2020-12-02" version="1">MDEVKRYAFFVTQAIKESVMETASHFQYGNSWPVKFYFGLLHILLLSLVFYIFLKSRNKGKSEKSIRRRGTRTFIKDNRAVTSETCQWLNSTLAWLYLHSDSKNTPDLVKLWIRNLNRELYKTRKDNQRIVITDIXSGCLPPKLTGVYCLCVDGTMQCITFHVESTELGFHVHVNQPMANGTSKNVILEVNVVKLVGEVALQLNNTPPLFEVKVMFIGEPEIKFSTRXITKDGIDAAAVEAVEEKLKEVICKTVTNVPLAESPTKTEPGSSGTKDKLESPILQTCVGEEGKLLVKVIKATGLCAKEKSGTVSPYCIIWADHPHQRKRTSLIKDTDSPFWNEYFAFEITSKTREITLNLFDFEKTSPDVNYHMDDNELSPEQDDFLGQAIVPLATINRNQTCRLILPILPKTNKCXYVKGELSLEFTFDKNGKVIDGALPLVDSTDNKPKTPVVEENVTSKTVKPEESAPVEDTPSGSFQRSYGPAYSYSLDKSYMETSLDELAQEIEAYEAESRTPVEENKSVELLMELKPDVQQTEKTPEEEPVHAVEEVTPVEAVVAEPSKEGEDVEDNQTEQQKENEEEHIEGTPEPEHKSKSKKSFTGKFKRRPKSTIEGEKKPDEEVNTQRHSYHAGDKAEEEQETKEGEKEEKKEGEEAEDTAPSELTTEPKSKIRRSFNMKFKRGSKKDEKEKDKEATQETDAPKAEEPTDESKEQAAMEESLQSDPPKSRFGGKFKRSKDAKNEPKDEEKENKEEKHELETVDENAESGTPAEKQADSKPKSRKLNLRRGKQRPVSMSAADKPGSTDDEGKLDRXDQVRHSYHAGDLPPPPPLRKSTSESSLLSYSPNPYSSLVIEVTEKDQKTYYHVPVAMAKRGTYEQKGVKYHVYNDHMFRATHLESGTECSVCGKSIFGRFGKQGYQCIDCKXTTHKKCHYQTSEMCSNSSIKNIEIKKAPNIVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1F8</accession>
    <name>A0A6P8J1F8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116305796</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571630.1">
        <property type="nucleotide sequence ID" value="XM_031715770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1F8"/>
    <dbReference type="GeneID" id="116305796"/>
    <dbReference type="KEGG" id="aten:116305796"/>
    <dbReference type="InParanoid" id="A0A6P8J1F8"/>
    <dbReference type="OrthoDB" id="5989681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="31"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031571630.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34391" checksum="EA478F757DCA4D28" modified="2020-12-02" version="1">MMKEVLLNNPRLNVLVSVLIRLIILVVGLFGNGLVVLAVWKKRTLRTTTNLLLLNLAISDLTTQVFCTLMFIPEFTTLGHRPWSDIFCILFVSTNVPLTTTFVSILTLTVLAVERYHAVVKPMRSEIRLREDTVKYACLAVWLAGIILALPLYIFGRYDEESGRCLHGWKDGVFGYQSYRIFLAVIIVLLPFLIISFCYGQILHDLYFKNKVGPQNIALQQETREKRKLFKISMTVTGVFALFLFPYAIFNGLRDDTGNLWSRVARLVFFSQSGFNPLIYSFQSTNFRQAFKEIFVCRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2T1</accession>
    <name>A0A6P8J2T1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307720</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573879.1">
        <property type="nucleotide sequence ID" value="XM_031718019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2T1"/>
    <dbReference type="GeneID" id="116307720"/>
    <dbReference type="KEGG" id="aten:116307720"/>
    <dbReference type="InParanoid" id="A0A6P8J2T1"/>
    <dbReference type="OrthoDB" id="10040867at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573879.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44344" checksum="DA379097A80EC817" modified="2020-12-02" version="1">MAVLLWFSGLCTFYALSNVILGITGTILLPLYFSFCGTEAAVRFSLLLCVHSVLLACIPKQVKSFIPMVQLVLFMLLLFLPINVTPFIAVWFYEKLLLLAEPVFSIVEAVLVVFLVMDGSQSLVDQIEDNPGFVKSIIIGVAFVSYSLVLWITFNMFMDENMIPLENWILLAVLAVSVSVLVICLIQEEGIISDASVVSLMMVCILWAMKQERIMTTNPLNMPKQWTESLVGGKSFLWALTSMASCSLSHLGQAKMILSSLVSPTYLMLAAIRVFSVICLIWIIKQFQAKDEDKDFEDTVIDDQSSSSIPQISPLTIRLVFIFVYTEFLVRSMVISTHHSMTSHSTPSSMIPTFYDRIGSILLYFLYEVRIWRVLQICMTVVTYFYVLLTPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2V8</accession>
    <name>A0A6P8J2V8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Serine/threonine-protein kinase SMG1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC116307792</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573961.1">
        <property type="nucleotide sequence ID" value="XM_031718101.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573962.1">
        <property type="nucleotide sequence ID" value="XM_031718102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307792"/>
    <dbReference type="KEGG" id="aten:116307792"/>
    <dbReference type="OrthoDB" id="10065496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031573961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573962.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64597" checksum="7FCDD6A2C767D2EC" modified="2020-12-02" version="1">MENTAKVAGDRLSDLTSREGDWFLEELCSMSGNVTQLLSLLRGHPLVIEEQKSSSKEELNNSIRGIFAVHKVFSALXEXMTNFRNIIVPEAIKSFTSGDPSVTHMLESLERLVHGEDIAALTKTVETEMNXTHECQGVNSSSISSKISILQQQFDAIQQSRNAIGKKSSEQMSAGQMLLAGFNGLFTKVESELDLMNAILAQVNSSFGNKTCDVVQEAKKLQESNRSGNSQLCSKLFFLRRLAVMAAFFKDCKELVENTKEAPESKARETVAEDQPQYNWIADKCYSEDELALHIRQFIAESVQKRILGLPSQAIGIIVYEYLNLLEDGSDSGDSSRVHSIEETCKKVIDIKIKKGSFQQKQFSQMSSLTSAYDVAWRKHDFARRLDHNISLYKGVVQRSQLQLARFQWLYEDDLLRCPLRDNSMISPAKASIMNDMRKRVQSLLQLEPAVKAIEDKIITQQSSIEQRLKWAAGANPALNPVLKEFDKTVNDRKQLLQLEAKHSSDICSLSNALIHFEMLRSQSHEVTALDSTITALVSKCKNSSSELEKSLVKLKAVSEMTSLLNIKCPPESLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J353</accession>
    <name>A0A6P8J353_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574401.1">
        <property type="nucleotide sequence ID" value="XM_031718541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308155"/>
    <dbReference type="KEGG" id="aten:116308155"/>
    <dbReference type="InParanoid" id="A0A6P8J353"/>
    <dbReference type="OrthoDB" id="5975476at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574401.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="56971" checksum="D5E141500CB82857" modified="2020-12-02" version="1">MYYSVCENNEKYQVLYRMEEFHPEEWSVLQSLRNRRDIVIKPADKGGAVVVWRTDLYKEEAFRQLSNTQFYCEVDKDLTPNNQSLVKGTINSFISNGSLPPTAVNLIITTPRTSNIYFLPKIHKDNNPGRPIVSACNCPTELISSYLDSLMLPIVKTLPTYIKDTNHALRIFNDFNFQSESKFLFTMDVKSLYTVIPNDEGLLALKHFFDRRTVLEPSTATLLRLAELVLTLNCFSFDNRYFKQINGVAMGTKMGPSYANLFVGFVEEQIFEQYSGPKPELFGRYIDDYIGATSCSKPDLDAFISFVNSFHPSLDFTWEISETSVSFLDIFVTITDNHLSTSVHYKPTDSHSYLXYSSSHPKHTLDSIPFSQFLRLRRLCSDDIDFSNKCSEMCSFLINRKYPVSIIDRALQKASSIDRTTALTPNSRSVNNRIPFVTTFHPINNSIKPIITRNFNILDADPTMPNVFSERSLFSFKRDRNLRAFLVKGILPSDKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J381</accession>
    <name>A0A6P8J381_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2/mitotic-specific cyclin-B2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116307910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574097.1">
        <property type="nucleotide sequence ID" value="XM_031718237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307910"/>
    <dbReference type="KEGG" id="aten:116307910"/>
    <dbReference type="InParanoid" id="A0A6P8J381"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="221"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="225"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031574097.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39896" checksum="D528D1FB5AF4990A" modified="2020-12-02" version="1">MEHTPSTDSDFDTNSYQVDSALEKPCPSTNCDWKFDLLCAPRPRARSRLNDSGFFQQDTNIIASNGAETDKSQSADCQEMIEDWTVMSSYTEEIFCYLYKLETKFLLPRDFLKHQEEVTYQSRAXLVDWLIQVHEFYNFPQDCLYLMISLLDRYMSLHYVPLAHFQLLGMSCLLVACKYEDRFVPSHQELVNMADKAFTADELNKMEKGLLETLNFDLSQPLPSHFLRRIARTAGIDAETYVLSKFLMEITKLDLVLVTYKPSLVAASAFCLASGLVWENGRLSLVPGSCYTLDQLMPCLVGIAKLIKFLTSLGCKGVIHKYCRLGIDNTIIDSLSVNPIIKDLLATNIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3E7</accession>
    <name>A0A6P8J3E7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116307939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574134.1">
        <property type="nucleotide sequence ID" value="XM_031718274.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574135.1">
        <property type="nucleotide sequence ID" value="XM_031718275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307939"/>
    <dbReference type="KEGG" id="aten:116307939"/>
    <dbReference type="OrthoDB" id="10287601at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574135.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="51202" checksum="F1E8542DFF6B03DA" modified="2020-12-02" version="1">MSQSLLNNKNGKLEKENQNSTLVAFAVFGCLIHVSFSVILSGTQDILAGTHIPTAXLLSVSMVPQFLVESIAPYFLKKIPHVVRVLIVFINACVGFIIVAYVNQVYWKIAGVAVVTSGSATGLISMASILSYFTPSATSAFSTGCGIGIFAGTLYYTALTTWLCVSPNVTIVVLSPLSILFLVSYYIIDRNKNNKYPDSTIHKDITYTKIEDNDTDEEKDEDPQQDREKKLSTRHSRNMTPDDESLTRKEKFLVIAKLFSLTVLPTFLTVFSYFLLNQSVITTIAYENAPFRPRDHYQYYVFAFTSGEMIGRCHRVLLSLVSLRWNYTPSRKLLWTFSVIEIFSLVFLIFESWYRFLPSVAVVIFFCILSGTILGLLFENMLLLLHVTFEGKRREFVMPYVMFPFSAGLLSAAFVGLYVESRLLEHCLSLVQDSAYCFTRSHSLKDVTVGCRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J529</accession>
    <name>A0A6P8J529_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC116306647</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116306647</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572585.1">
        <property type="nucleotide sequence ID" value="XM_031716725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306647"/>
    <dbReference type="KEGG" id="aten:116306647"/>
    <dbReference type="InParanoid" id="A0A6P8J529"/>
    <dbReference type="OrthoDB" id="6022320at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028251636" evidence="11">
        <location>
            <begin position="26"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="125"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031572585.1"/>
        </source>
    </evidence>
    <sequence length="1156" mass="126886" checksum="7E0BE11868D30A2C" modified="2020-12-02" version="1">MTFRAAFFWGIISFLVFVFAGAVKSRPVGDEVCHIAKEGECGCQCIETRTSTWSSLAYLYKRIFVRSFSPLELEIECQKCQSECAEHLRSQCKNGKCVSNSCECHQCWEGKTCDQAANDNPPQFEQKSYTAQITANSEVGAIVLTVGAFDKDRKRCAKEVPCPCASIVYSITRGNEDDFFSIEKHSGKIRVSKSLTAHDGTSFDLTVSAENEGQGFNQQKDTAILRIDVAALKQRHRRSADHHIVRRSTPIASPSGVIVVKPEVQNNTFYKPGDSITFNVTLSHNQSASTFAPDTDLQVKCSSTFLNVSEYVASKGMPSSGHTVSNGEITFNVISLPQAGVSSVIFKTTVKSTIHPLANLYMVCEATGTRASTNYKISPVSSSPSLYAVFPKVTLTRITEPSKSLFEIEDSLQYRMIIDMPHLDFPLFVEVTSAINDFSFMPIQDVKISAKGSNIGAGPGGNVDPVPQYTKSSNDLTFFDSATLDFKNLTVAAESDVNNKIEIQWKVNLTDHPLLANGSKHWNGAGLSSGPNMLHVAQQAIYMKKIEPTLACALTPQNDTAATRFSIDDTLSFNLECNHTNTSTADAKNXVVKCYSTYLDFVKASYTPTGGAVTQVTKMNDTMLTDITVANVPLGTKITGNFNMKVRQNINPLVELDVFCQIAYQNLADKNKMTTTHKAVPPAVAAVPIITLNIVNPLSCYKVGSEIELAFXVLVRKMNTPLLVELIAPVNSSSPIMAITSVTSPTVGANIMNKASLESKRVVCKSTVNDTMYDRCTIDFGTVTSIVGVANASVNEISLNFNVILNDHSNVTNGSKYWPAVGVRGGSRMMWIGETAVTVCMSADPKPVLKLESKCYVPSTSQSCCEGNLRRNDNVQFNITLSHDLTLSEQHAQNVKILHMIPIYVKYWREIFKSPSGMTYNETPGGPELKDIKELRFKEELSFSYLATLDPLNIMPPGDIQATSVAEVTYYGHDGLTVLSRKAGVCCYYQNPGPSRESPXQEPSPLPEYYKRGFLLIPKSKTLFVCSENTARTSCFYTSDAGVSWVAINEQVGRIIGNVGETLYAISSNKRAYMMQQTRADTWYAITPDDWAKVKTSAETNRKVVEDNHTNEGDPQIVSSDSNTNKYGANKNGIYFRSGSAGTKSWVQKAMWKCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6A9</accession>
    <name>A0A6P8J6A9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308886</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575297.1">
        <property type="nucleotide sequence ID" value="XM_031719437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6A9"/>
    <dbReference type="GeneID" id="116308886"/>
    <dbReference type="KEGG" id="aten:116308886"/>
    <dbReference type="InParanoid" id="A0A6P8J6A9"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575297.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="71601" checksum="0875B38F448FD095" modified="2020-12-02" version="1">MDSLPCEVIAQVFSNVHPIYSDLLTLRQVCWKWKRIIDTTCHLWKHIHLDDDRDCITMDRGTTEKDCKYTAILGFCLRKYGRFIQCIRAEDQPFLNSPEVRKLIPRLENLRKLDVPWLTWSKQMAENFKSKSLKHVTIDDCMIQEHLSASCLERRRAVSRGLKGWDLRFLYMWFPNLEHLGLHTSIYKIRRGSIVSILDPMVKLKEMSLELTPYALKPGDEELSNATGVPPVREIMNSRHCSILTSLELRYLALSSKDLMDFTRGLTRLKHLVVGSIASMNNEVFNTALVLESASLEVLFLSSLPSSWTQTIKISMPDLEVLVISQCIELISLELLTSNLMTLILRDNLSLSNISAKCECLTDFELLECFEFDLESFKKFIKECSNLMRLELTVEWKSIELTSQDCPNLRKFIIKDADLLLSRVKIDCPTLEVFKCISYYAPRKSCRRYANKECQFEIICEDLKKFHISEVYHTTEVRVQCQTIDTFDLIGRTLVLRPMELYITATRRINVISLKDLSIKSVRICCPVVSDIILNTCYMPNSKNNSCKMKIKCEDLKALRVIDCDRIKKFALKVPHVEKLSLDSCTRLCDLHIAKVSKVDQVRIVNCPLLNSTNVLYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7U6</accession>
    <name>A0A6P8J7U6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cryptochrome-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116307704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573863.1">
        <property type="nucleotide sequence ID" value="XM_031718003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307704"/>
    <dbReference type="KEGG" id="aten:116307704"/>
    <dbReference type="InParanoid" id="A0A6P8J7U6"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF30">
        <property type="entry name" value="CRYPTOCHROME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="322"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031573863.1"/>
        </source>
    </evidence>
    <sequence length="814" mass="94477" checksum="AE1CF7A8E22ABBEC" modified="2020-12-02" version="1">MLKHSRSPESLSSISDTVPDLTEFGVNSKTKLTARRHWKGGENEALRRLHLHLKKMEELDFKTNKLSAEDFLPNDTHLSPYLRFGCLSPRLLYHCIGSIFRKKKGCDPPDIIYRPLLWREFLXHMANDNTNFHKMRNNPMSLKLPWEIEDYGLFRWKQGTTGFPWIDAIMRQLNQEGWIHXVAREAVGCFLTRGCLWINWEEGYKAFDELQLDSEWSLNAGGWMWVSCSSFVHGSVPWYCPVEAAKRLDPCARYIRRYVPEVRHLPAQYMFEPWKAPLKVQIAARCVVGYDYPEPMCDHRVQRKICVERLKVISRDLNTRTHNTIHWFRKDLRLHDNPSLLKALKDSKTLYGVYFLDPQLLKGTTKVSPKRVVFLLQCLRNLDNNLKRNGSRLFXIQGRPFEQFPRIFKDWDITRLSFESDLDPHARTRDTAIRNLAEKSSIEVISEISHTLFDVNEVLNANQKETPMTLDYFELVAASLKVPDPVTTIDGGVLDGCMTLVERDHDVKYGVPDSSYIGLKETYKTACSPFKGGETEALVRLDKAILKMKNSKFTETAKVDASCFLASDEALSPYMRFGCLSPRLFYQRITTAYREVTGQSPPLPVYRKLLQREFFFVTASSNPELQKMKNNSLCLQLPWEQNNPALQRWKQGTTGFPWIDAIMRQLRQEGWIHHVAREAVGCFLTRGCLWINWEEGYKAFDELQLDSEWGMNASCWMWLSCSTYIKGSVPWYCPVEVAKKMDPAGDYIKKFVPEVRNLPTEYIFEPWKAPLEVQEKSGCIVGKSYPYPVCDHIEQRLICVARLKQFKTMLLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9H7</accession>
    <name>A0A6P8J9H7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC116307409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC116307409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573515.1">
        <property type="nucleotide sequence ID" value="XM_031717655.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573516.1">
        <property type="nucleotide sequence ID" value="XM_031717656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J9H7"/>
    <dbReference type="GeneID" id="116307409"/>
    <dbReference type="KEGG" id="aten:116307409"/>
    <dbReference type="OrthoDB" id="10021598at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696">
        <property type="entry name" value="AGAP012002-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573516.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24963" checksum="4ECCF215FA51A9C0" modified="2020-12-02" version="1">MREVVRTLSSVSYQSSAKAHESPQDSSSTEDLKTIGRLKEDESKRTRADNTKAWLQGPLSLSRKGCRFELPMDMKLLEKLTPLEYVSNYCRINSRRKTLFRHYFMKNDKDKDGNVNHRELLKALRELYAQSISVQQVNEILHSLGIEKMCKNVTLNMFLAIAAFSERYLYSFLNNTSEYQEEKRTVLEETDFGALRWKLEGCAVSDEMKNILCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JDI3</accession>
    <name>A0A6P8JDI3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116308301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116308301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574550.1">
        <property type="nucleotide sequence ID" value="XM_031718690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308301"/>
    <dbReference type="KEGG" id="aten:116308301"/>
    <dbReference type="InParanoid" id="A0A6P8JDI3"/>
    <dbReference type="OrthoDB" id="5987918at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Smr" evidence="5">
        <location>
            <begin position="1026"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031574550.1"/>
        </source>
    </evidence>
    <sequence length="1227" mass="139425" checksum="558B8EBFE7C29D75" modified="2020-12-02" version="1">MTTMIRKVWRSLTKPVFHVIMDKADNTSKDVIAGQTTQICTITIYLHXDRKLGKHQREVKFPRLIIXEVPGVDISFGDKIQHGREALEIGVFVRATTCGRYCITPRFLEKKYNFKLNNITPVDFEVRPAQLHSLELFKIGSTRSQREMYLGSSVYRGCQTEIWLKAKDKFGNPTILDDEFKISSDSSKYVTLISTTPDIEFGNYLVTLLCNEVGRFSFDLLLSNTDMKLEVNDFEVLLPPVSPTNSYVVHTIEVNTSQEKSLKAGKVITSELFLYDIFGNQISCEESKGFFDGIRLVCCDVMTSTGFHSPHVFSTSTPTKETKKEEDSLKVCTAESDSNACVVKFTPLITGKRLLSLNVDGKEIKNSSIKLTVQPGPPHEVDILSQEPSSLSVYRSRTAKIWVTVKDEFGNQHTGSDVSFKVLSKGSFVTLLSFTYDPEKGGYVVIVRGDKTGKTSFDLIVSRHNREVVKCISLEVITPPVSGSNSYVLKVDKRQNSILKVGEAMELALMLHDIFGNKISCEESKGFLERLRLICCKVRASTCFLSPHVISTSTSTKKSKKEEDSLKVCPVESNSNACVVKFTPLVTGKRLFSLNVLGEDIKNSSIKLTVQPGPPHEVQILNREPSSLSIYRSRTAKIKVTVKDEFGNQLTGSDVSFKVHSKGSFVTLLFVTHYPESASYVVTVRGDKTGKTSFDLIVSQDNREVVKCISMEIITPPVSHSNCYIPQNDIETLQKTIHKSGKVITFQLKLIDIFGNPIAFEERGNFPENVRLVYLHDELPGWSSSDGNNRRKKTSLRVRRCEFDSCELGFTPLKAGKRWFFLEIAGEMLKNSKMRLAILPVEGQNVELDFEESYACGTSGDKVRTISFKQDNYIEFYEHHRNILCKGVSRRELVGADKANIKNINRVLEKEYPDCKLSNDMITRDYVRLVLFDLSNFPEAAALKVLELLSLLVGSEHCRSQANEMGDQREKWQEEEQQAILDENSREAKEFRVVKLECGRLMNENNEKASDFIFKFYNYGRPQSEIDLHGQRVANAERLRELRAKLLRENKTEAQVQEIIEKQRQKRDEAIRKLDERIRTFDHEKAKRDGEDWLEIIDGAGHHSATKGQQKIRPKVKEYLKKKXIKYVEANEGALLVTFSEYTGQQPCVGNFYCTKCKKGWTSISSWQGFYQLCNKCYAKGTESNCLPFKLRSTLPPKRQGGEFTRQDHRRLCEKCIQLKKDCRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JGK2</accession>
    <name>A0A6P8JGK2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116309004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116309004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575390.1">
        <property type="nucleotide sequence ID" value="XM_031719530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116309004"/>
    <dbReference type="KEGG" id="aten:116309004"/>
    <dbReference type="InParanoid" id="A0A6P8JGK2"/>
    <dbReference type="OrthoDB" id="5977230at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995:SF7">
        <property type="entry name" value="BURSICON SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995">
        <property type="entry name" value="PROTEIN CBG18546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027714812" evidence="2">
        <location>
            <begin position="25"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575390.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34898" checksum="D21CF217100F73EB" modified="2020-12-02" version="1">MKAPHLLIACLSLALVTMTMLSHASSTSSKDGSNRNDDQETSENPCKEVWENTTVSXPEGLVFCMVPSEEELTEQLKSIGGYNRHYVAVSSEEAINFEPILPGWDGAETTKPTSSSRRCRRYRHPSFRKRRRNXKRSDGLEQLGWEDEKDDSELEKEQTKRSDKSAYRGMASKEQAKXLQRSKRFLEVGIRESIKVGCVTKGEAINSLKQMCDRCQRRTELTADRFPRYINEVTCESSSGSPSDGTSYCQPQVGVCAQGYLLIDLLKRTDQYTNVSPPSGMYFKAFKQIWVPYVHKIRSCCECRSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2K9UYQ2</accession>
    <name>A0A2K9UYQ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Globin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10 11 12">Neuroglobin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14" type="primary">LOC116292989</name>
        <name evidence="8" type="ORF">A.tenebrosa_nvec3000224</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Evidence for a large expansion and #subfunctionalisation of globin genes in sea anemones.</title>
            <authorList>
                <person name="Smith H.L."/>
                <person name="Pavasovic A."/>
                <person name="Surm J.M."/>
                <person name="Phillips M.J."/>
                <person name="Prentis P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11 12" key="2">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KY810201">
        <property type="protein sequence ID" value="AUV50080.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556223.1">
        <property type="nucleotide sequence ID" value="XM_031700363.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556224.1">
        <property type="nucleotide sequence ID" value="XM_031700364.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556225.1">
        <property type="nucleotide sequence ID" value="XM_031700365.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556226.1">
        <property type="nucleotide sequence ID" value="XM_031700366.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556227.1">
        <property type="nucleotide sequence ID" value="XM_031700367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2K9UYQ2"/>
    <dbReference type="GeneID" id="116292989"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Globin"/>
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        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
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        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01907">
        <property type="entry name" value="WORMGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AUV50080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031556227.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20082" checksum="11C036084FE97B92" modified="2018-04-25" version="1">MGCGASVAVNGHVLSGTSCTSVAFQPIPLSEEQKKLIYQTWSLVEPVKVAAGRKLFARLFELNPNLQSTFPAFKGLELKDILNSRSLYLHAKRVMNAMENAVSSLNDSETFTCYLANLGDRHLPWNIQRQHFDIVGECLLWTLQDMLGPACTTDVAQAWAELFGYITESMLSGIDRAKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZQ6</accession>
    <name>A0A6P8GZQ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kielin/chordin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549649.1">
        <property type="nucleotide sequence ID" value="XM_031693789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZQ6"/>
    <dbReference type="GeneID" id="116287149"/>
    <dbReference type="KEGG" id="aten:116287149"/>
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    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWF_dom"/>
    </dbReference>
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        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027791165" evidence="2">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="3">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549649.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33533" checksum="BB0C136CA311DF90" modified="2020-12-02" version="1">MVSCIRMILPLLVILYFISLDVSANQQTIYRIKGDFGSPVYIELESIGCFRDRPSRALRNMYANFRSSIRWRSYPDTSYMVKACAESAYQHAYPGMFAVQYYGECWSDGSAEERYNMYGVSTNCEHGVGKDWANMVYRYKVVPKPTSCHINGKVYNEGDQMFLNSNSTSCKLCTCSNGEAKNCKGLHCETDYRTLCLKLKYLPGQCCPVCECSNNGQIMPVGSTWLARKDSTCAECTCQANNVAKCFIKSCKCNGDLIPIEIPGKCCPKCVAPTTASPRPETVPPTTERPPPIIPPRPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H195</accession>
    <name>A0A6P8H195_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116286981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549443.1">
        <property type="nucleotide sequence ID" value="XM_031693583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H195"/>
    <dbReference type="GeneID" id="116286981"/>
    <dbReference type="KEGG" id="aten:116286981"/>
    <dbReference type="InParanoid" id="A0A6P8H195"/>
    <dbReference type="OrthoDB" id="10039170at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549443.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39999" checksum="53B7EF38C73FF8EE" modified="2020-12-02" version="1">MRDLQASISQLRRFEFELPGKSVNKRRKEVRVSSSAPRSYSRTAHQTKTKSACSAKSTSLTHKCISIGDITNSKDSQHILVGSALRRPHATGYSTMDYQTMPDVGKSPRQPYRPQTASTVYAYANRPVSAAEAGMKHGRQTKSSLLRKKSSSCESLSSVSSSESLSRTTLSANTKKRLCKIREDYRPFKGGHLYQPIPPNGESLHSFLIGARYNNTRFIDSKTLSKLGVYIPKADLKTFFVKENNWMKQSYDNADDIYDDNELNMVAVIDEGSGDLQSHPNNEAIENPVDTENKAVNTDPHYLSIDRWHSAEWYTDRKPTSQKAPRAHTAPSRFKPINTFYYDYNSGKKYKCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3A1</accession>
    <name>A0A6P8H3A1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116287549</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550093.1">
        <property type="nucleotide sequence ID" value="XM_031694233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3A1"/>
    <dbReference type="FunCoup" id="A0A6P8H3A1">
        <property type="interactions" value="1880"/>
    </dbReference>
    <dbReference type="GeneID" id="116287549"/>
    <dbReference type="KEGG" id="aten:116287549"/>
    <dbReference type="InParanoid" id="A0A6P8H3A1"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
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        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="104"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="282"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031550093.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38013" checksum="62DA2E62643802F8" modified="2020-12-02" version="1">MAMQERRRQQARQQEETMEEADAEQSGPLSIHKLEEHGISASDVNKLVDAGYHTIECIAYTPRKALLAIKGISEAKADKIIKEASKLVPMGFTTATEFHMRRSELVMITTGSKELDKLLQGGIETGSITELFGEFRTGKTQLCHTLAVTCQLPIDSGGAEGKCLYIDTEGTFRPERLLAVAERYGLSGQEVLDNVVYARAFNTDHQQDLVVEASALMSESRFALMIVDSATALYRTDYSGRGELSARQMHMARFLRTLLKRADEYGVAIVITNQVVAQVDGASMFQADPKKPIGGNIMAHASTTRLYFRKGRGETRICKIYDSPCLPESEAMFAINADGIGDSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4D2</accession>
    <name>A0A6P8H4D2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287854</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550408.1">
        <property type="nucleotide sequence ID" value="XM_031694548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4D2"/>
    <dbReference type="GeneID" id="116287854"/>
    <dbReference type="KEGG" id="aten:116287854"/>
    <dbReference type="InParanoid" id="A0A6P8H4D2"/>
    <dbReference type="OrthoDB" id="10369069at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027962799" evidence="1">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550408.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27068" checksum="7D47828868C70D0F" modified="2020-12-02" version="1">MTWQRSFLFRMIVFLTFFHPDCFNNSKFEDPGPAQKENVKCITNQIEDDLMIQSLTDFSEPDKRQKNPVIERRVPEGTDFMYECRNLKKEAILKWGLYKRGVSSPSRLFSRVEVAKAKSFCSVYWASEFKASRYSGRIHVEYNTTSQCVIWILSSVTREDENIFVAAVRDNFAQGQGFRECTPVSLNVFKANTPVPTTPALQTTPVTTQKPGESVFNQFLITFSVTFKYLIFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H558</accession>
    <name>A0A6P8H558_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM91A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116288803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551504.1">
        <property type="nucleotide sequence ID" value="XM_031695644.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H558">
        <property type="interactions" value="2263"/>
    </dbReference>
    <dbReference type="GeneID" id="116288803"/>
    <dbReference type="KEGG" id="aten:116288803"/>
    <dbReference type="InParanoid" id="A0A6P8H558"/>
    <dbReference type="OrthoDB" id="5949424at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="381"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551504.1"/>
        </source>
    </evidence>
    <sequence length="853" mass="95750" checksum="551EAD39E67B4E09" modified="2020-12-02" version="1">MARQSVNADLEFHIRQNYPWIRLPASVKQSLGNNQREWEKSVFDYSVKNQLRYRGNIVRHVRKDEKKYYEDLLHYSRQHLMLFPYHLSDVIVKGLRITPFSYYCSIMQDIMQSERSYDSLPNFTAADCLRLLGIGRNQYIDLMNQCRSSKKFFRRKPVKDLLPTKPXALKVLEPWWTVHIGYVTEDDIRMCSAAEHQAVDQIIDGGPKLAAEMDLKVVEGLYAKGLIYVGVPIKDEDYIVVPPLENFVMNRVLGDYFETLLYKIFVSIDEHTNIAELAHVLQIDLQLVKNAVSVYCRLGFARRKSGELGYESKIHKSWSEKILNMLSSKKSGSRDNLLDLDFNHLDDKASTTPGEQSASSSEVTEMETLLSTQSPVEGGPGKRIAFLFDSTLTAFLMMGNLSPGLKNHAVTMFEVGKLTDESLDSFLSELEKVDNVAEGEAQRYFDHALTLRDTILFLRYNKNLGADKCSVPAMGLDLLRCESLNGLDPAACSRVLQKNYSMLVSMAPLSHEIRPVTSCVPPHLGPAIPEVNSVWFKLFLYHLVGSGPPSLLLVKGTRLRWLPSLFEDYENLLITTWGHDPGVVPISNVLMALNDALSHSAVLVQAHGVHSEGKVIHVAFPLEINEGGFSMDNIAAHPAIQKLDEQLDLDHCCGYISMLNTTINTKPYRGTSKLSPDGSEETSRTASPSEPTNGSVMSFDECLDDIEDDEVNGDRNLDCRSSDDMVIVTDRIRPQEEGGIGPCCSPDDWVPLDLCYGVPLFDSDLSEWICQKISSNGLFSDDSLKQLVQSSRSLTLTLLDFIEAHKGNNVTHETSDHKAFTSTANSSPEETVIAYPTRNLIFSNGILQEWDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5A6</accession>
    <name>A0A6P8H5A6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Death-associated protein kinase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031550663.1">
        <property type="nucleotide sequence ID" value="XM_031694803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5A6"/>
    <dbReference type="GeneID" id="116288077"/>
    <dbReference type="KEGG" id="aten:116288077"/>
    <dbReference type="InParanoid" id="A0A6P8H5A6"/>
    <dbReference type="OrthoDB" id="2570713at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550663.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37770" checksum="16F1A266B708C311" modified="2020-12-02" version="1">MSNLAAKKFGPQTMELKKESPETSYQIKAEVARGKYAVIKRCMDKKTKKNMMAKLIKYDSDTEKLAIQEFEIMKDLKNDKLLTARDGFHVRKYVIIMMDGVEAKNVLEFLGEKPRANEEDVAFVMRQTLDALKYLHGLKIVHLDVRPANILVKKDYTLKLIDYGCARRIVNDTGDLVDAIGVTEFSAPELLNMDPVCWAADMWSIGVLMYIMLSATLPFTSEDEDEITAAVTAVDYDMPADKFGKATDEAKNLVKKCLVRVPEKRPTAVQVLEGDWLSNNNSQRRKTTDIPSSKFKELNQALQDADKEEAVVASCTLRTFEEQEYESPDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6X8</accession>
    <name>A0A6P8H6X8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related protein Rab-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551103.1">
        <property type="nucleotide sequence ID" value="XM_031695243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6X8"/>
    <dbReference type="GeneID" id="116288453"/>
    <dbReference type="KEGG" id="aten:116288453"/>
    <dbReference type="InParanoid" id="A0A6P8H6X8"/>
    <dbReference type="OrthoDB" id="8821495at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031551103.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24368" checksum="73F5DBC3026F9D6A" modified="2020-12-02" version="1">MANKSYDYLFKILLLGDSGVEKSKILFKFAFKDDDNFISTIVGSEAFYIPIPLSEVCFNTYGSSGVLNLYFFIRDTAGQERFHTITTSYYRAAAGMMVVYDITQEKTFENISKWLRNIEEYAPEDAQVMIVGNNCHMENKRAVTKGRGEQMAKENGLRFFEVSAETNENINEAFYTLAEDILTKRLSKDSEELSSNVNVRDNPEADQKKGCLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H772</accession>
    <name>A0A6P8H772_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551153.1">
        <property type="nucleotide sequence ID" value="XM_031695293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288497"/>
    <dbReference type="KEGG" id="aten:116288497"/>
    <dbReference type="InParanoid" id="A0A6P8H772"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551153.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30508" checksum="B8C56D35A9BDC832" modified="2020-12-02" version="1">MAKNWPPGTHGLFNDLNCNIYRMFICEYKNEVNHTQGVLKFCPTVTTTQRPTVTPSRRTNIKTTMSNELTSLSMSHADPPATPEPLTEWTLRNASILSPDPQALGTSSPANAPEGFPTMLVAIVLGILLAVGICMFFVVFWWMKRKSGESKSEKKPWQSYAVSTPMAENRAYLTNQRNNTPGQAVGTEDMQLYAEPDVLYAEIADDYYLQPCDSFDSPAPSSTHSEVEYANSPSPSTXPTGYADLVQNPVYENHMXYQPLNKYPGEIEEDEIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7E5</accession>
    <name>A0A6P8H7E5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone deacetylase</fullName>
            <ecNumber evidence="3 12">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116288571</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_031551233.1">
        <property type="nucleotide sequence ID" value="XM_031695373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7E5"/>
    <dbReference type="FunCoup" id="A0A6P8H7E5">
        <property type="interactions" value="2946"/>
    </dbReference>
    <dbReference type="GeneID" id="116288571"/>
    <dbReference type="KEGG" id="aten:116288571"/>
    <dbReference type="InParanoid" id="A0A6P8H7E5"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11681">
        <property type="entry name" value="HDAC_classIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000002">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046949">
        <property type="entry name" value="HDAC4/5/7/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037911">
        <property type="entry name" value="HDAC_II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="16">
        <location>
            <begin position="748"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="121"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="466"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="874"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="742"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="822"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031551233.1"/>
        </source>
    </evidence>
    <sequence length="1157" mass="128019" checksum="7C7806A3A89C966C" modified="2020-12-02" version="1">MDAGDSETSGSRAVTGKTPVMPIPSQYLKQYYAQAMGDNYSPPQEGPNMPYILTPAQQQLAGILQFKQQQQQLEQLHGVHQPQYLQQQLLYIQQQHLLQQQQQQQQQHELNYRLEMQQQALNGHHHKQKKFERDHNNQSSMEHDKPIPPKPKIKVEPEDEPAQKEEEVLMDQDEDAGNRMSKEDHNKSLSQPKPPHLPPATSSAASPSSASSQTAQELTSSAVKKKLQTFVLNKQQRELAVASLTNDSAFKHWSQNMDKEGDDLGPLGSHLDANHFPLRKTASEPNLKVKSRLKAKVAEHRTIGSPLLHRPHRNGNKLHRSMTLETTGNENADRSNPGSPTQSVSASPGRERSSPLGAPGSTFGHSLPNLQAIPRLSANIDRSHISKLLANRYHFLNHASLASQGISNDAEFQSPYANDALYDSMEEDDDSSLNAAALKQVQFKNLALAKAQSKMLGLSGGHVHNSNSLLSRGQHPSLTGRGSPPSQNNLLSIPKSTLSPTSQASSLHHRPLRLTLSAPGYSISNNPQLQQQQILKQNQELLQQQQHLQFLQQQRLQQSQSLYLKQLQQDLLMQQLGKQNFPKVPQPEKEPRGTLKDHLEMLQFQKEQEQAVLKEKAYQQHKKEQQLAQAARTTEDLPTSRPLNEQQIQELLLVQQFQRQDPHQRGMLQQQLLQHQQLLQLRQAEVQAAPSAASASPSASIGHRPLARAISLPAVGSGQAATPTTRTGIVYDTLMLKHQCSCGDTSSHPEHPGRLQSIWARLQETGVTNICERVRPRKATLAEILTVHSEQHTMLYGGSTQCRTKAEDGTITTLKCFNTLPCGGMGVDGDTIWNEIHSANAARMAVGCVVELAYKVAEKELKNGMAIVRPPGHHAEAHQAMGFCYFNNVAIAARLLRLKMSVERVLIVDWDIHHGNGTQQMFYDDPHVLYISLHRHDDETFFPGTGKSEECGAGIGVGYNVNIAWNGGLDPLYGDAEYLAAFRSVVMPIAREFDPEIILVSAGFDAATGHSPQLGGYKVTAACFAQLTKQLMELAQGRLVMALEGGYSLPSLCDAAEACLRGLLSQELPEVPKESLTRPPNPNAVAVLEKTIAIQSRYWNSVKRTGSLINHSVVEAQQREKEELETVSALASLSMAPGVVQDSDKATDDQMEVQDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7N4</accession>
    <name>A0A6P8H7N4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type E3 ubiquitin-protein ligase PPIL2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">CYC4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Probable inactive peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116288791</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with PRPF8/PRP8, EFTUD2/SNU114 and PLRG1. Interacts with isoform 2 of BSG. Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031551491.1">
        <property type="nucleotide sequence ID" value="XM_031695631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7N4"/>
    <dbReference type="FunCoup" id="A0A6P8H7N4">
        <property type="interactions" value="2753"/>
    </dbReference>
    <dbReference type="GeneID" id="116288791"/>
    <dbReference type="KEGG" id="aten:116288791"/>
    <dbReference type="InParanoid" id="A0A6P8H7N4"/>
    <dbReference type="OrthoDB" id="30774at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000018">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="23">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="22">
        <location>
            <begin position="286"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="447"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031551491.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="58910" checksum="CB88D45F1A8F4C6B" modified="2020-12-02" version="1">MGKKQHQKDKLYITNKEWKEEWGGKKKDVGERAAFRRLPFSCCSISFQPFEHPLCTKEGVIFDLLNIVPYLKKYKCNPVNGEPLELKDLIRLHFHKNSDGKYHCPVTFKVFNANTNIVAIKTTGNVYSLDAVEELNLKAKNFKDLITDEPFTRKDIITLQDPKNLEKFNISAFHHQRNNLKVPDKDEERAMRDPKFYLNKANKETESVLSELEKTYKEPEKKQAEKKELVTDRNAAHFSTGAVAQSFTSTASDRVTQQVTAAVEKDVVRYREVKKKGYVRIQTTHGDLNMELHCDMVPKTCENFLKLCKKGYYDNTIFHRSIKNFMIQGGDPTGTGKGGESAWGGAFKDEFKPNLVHQGRGVLSMANSGTNTNKSQFFITYRSCRHLDRKHSIFGKLVGGLETLSAMEKVETDDKDRPKETIKILKTVVFTDPFAEVDEVLRLEKEKEAEAERQRQEEADKARKRAAAESGPKVHRPGAVGKYIPRKAGKSSQDDDSLDQPVKKKIKASGFGDFSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7U0</accession>
    <name>A0A6P8H7U0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATOR complex protein NPRL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nitrogen permease regulator 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548535.1">
        <property type="nucleotide sequence ID" value="XM_031692675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7U0"/>
    <dbReference type="FunCoup" id="A0A6P8H7U0">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="GeneID" id="116286218"/>
    <dbReference type="KEGG" id="aten:116286218"/>
    <dbReference type="InParanoid" id="A0A6P8H7U0"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="3">
        <location>
            <begin position="479"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031548535.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="63043" checksum="FCC9C2C24DD3D919" modified="2020-12-02" version="1">MNSKDTSCDPVAIILVTAGSRGQRVLFRYPDHYRRQEVANDKKEIYKNFYIAPAKVEDNYSFSDSTLANILTPNIELGGKKFELKIDNVLFVGHPIQLQQKKQESKRVDSSKRNENVMLKLFNIVFVLKAGVENSVINCYHDLSKRLAIALKHEEHRCFYLTSQREKMLTVHDEMSTMPEADLTESPFHHMLPRSSLARALRDTFESLCESGVVQLKVNGWVNVSFCLPHKVHNLNQGMLTINPKAIEASLAAMRPYHTLLFLVDEETLLASLPGDCSPALMRLIRRASPLKSFTTLSQDTDIPLSQIFAIAAHLVYWGKASIIFPLCESNVYTVAPGISVDKSSKLVNEFSSRFPKMSLHAMLAEFSLPSPLAEHHNPLGSPQQQAEEVQMVFWMLQHRLLIQLQTYVFLVPTAQWDQQSDALGNARGRRRIRWIFGGSFTDDLVTFADDDTPLGDNDSDEETEYSNILNSVKDLSFAERKSIMQLAVASDEEDLKLFARLVPYFRGKHHLEEIMYYENLRRSKLLTLLDKFRDVLFLCQHEDPATACFHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8E9</accession>
    <name>A0A6P8H8E9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD repeat-containing protein 75-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551776.1">
        <property type="nucleotide sequence ID" value="XM_031695916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8E9"/>
    <dbReference type="FunCoup" id="A0A6P8H8E9">
        <property type="interactions" value="2209"/>
    </dbReference>
    <dbReference type="GeneID" id="116289039"/>
    <dbReference type="KEGG" id="aten:116289039"/>
    <dbReference type="InParanoid" id="A0A6P8H8E9"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="337"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="758"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551776.1"/>
        </source>
    </evidence>
    <sequence length="839" mass="94671" checksum="E6394619875B1736" modified="2020-12-02" version="1">MLSYEKESRNLGTIQLVGGETLVTLPVQFSRDSRHFFYCGGNKIYVYSTETGQLVRELKEHAQDITGFSVNSKNDLQLVSCCNEGLVIVWDYTDGALLKKLEFSDKLLGVFSHPNYEDSLFIIKKIYKGKRWKPTLIQVHLTKTDENGKPEQKNLFKFTGLPKHCCFSKKGRYIAYLHKRGEELGIWDTKANEAKSFLYKDSLFTCVAFHPNEACVAAGDQNGRIIIWQGIETKKPVTMQLHWHAHPLASVAFTHDGSYMISGGQEAVLVLWQYSSNSRQFLPRMGSPIKHVACSHDDSVIAVSHEDNVIKLVSGIDLSPKHTIQGLRKSSYMQSKLVFDPRTGTMVLNSMPGILQFYDPYLDKGIFVVDVVKQNLISQTEDEKLFFTLIHHVAFSETGDWMATVEHRKDHCTTEETRLKFWEFNATNQCYSINTIIDTPHDHRTVAVQFQPASQNSEPTMAVTAGHDGKFKVWVLNEKQGVAGTKFVWACQSVGYYNDTPCLDAVFSEDGQLLAIPYAQVITLWTPNANVLQKTLHLPFPDDKIRFTAFGFKSSSHYLMVSTAHYLIVWNLLTCSVLWTIEANVGHLISDPNTKHFAAFVNFDKKTHLYIFDPSTPNPVAIQPFVSCKAPVFSAGFDRKVTTLSSQDRPITLSKLFFRTRIQELFTLVTEDENDERERTSVPSVVEDDSSAKQDFFNIFGMPSKSVGESTSVQPLGKVVQGDPKAAAIREMMRIPSHVLPPVSTLCSSFLKSMLVSKEDDRNDGTNTDKQGADDDDSMVDEDSESETEATGPVVLKSQQIKEAQEMPFMDTDDTDLDEVHVKKKNFDWLKDVFLSHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8J2</accession>
    <name>A0A6P8H8J2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289070</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551821.1">
        <property type="nucleotide sequence ID" value="XM_031695961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8J2"/>
    <dbReference type="GeneID" id="116289070"/>
    <dbReference type="KEGG" id="aten:116289070"/>
    <dbReference type="InParanoid" id="A0A6P8H8J2"/>
    <dbReference type="OrthoDB" id="5968206at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031551821.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="30896" checksum="46DEB9C375106049" modified="2020-12-02" version="1">MPAYLPKQTVTRGSTVEIKATDDAGTKYRWCVLGIWNAAHGYLNPRLLQVLNYSKKNQAKVMPDTGYESRVSFFGDLDVGKAWFRVTDVKEEESKLYGIRCYSDQRKVYYPVIKMKLKVLPAEKEWEPLGCYEDSSDRALSFYHGQINFDDSPGGFKRMFEECKKKKAEDKGFEYFGIQHKTECWASPKNEEITYNLHGCKNNCWRHDDGFGVGSHWSNFVYRLKKDWSSCKDGFQYKLVAKQDTCYECPPYNVKIEKSETKREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8J5</accession>
    <name>A0A6P8H8J5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289077</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551826.1">
        <property type="nucleotide sequence ID" value="XM_031695966.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289077"/>
    <dbReference type="InParanoid" id="A0A6P8H8J5"/>
    <dbReference type="OrthoDB" id="5967731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551826.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20309" checksum="991632782006BC26" modified="2020-12-02" version="1">MTYKGTLKYVNVLQDIVEGYNDRYHSSIKTKPRLVNRENEDHIWHVLYDRDLIDGKTKFAFHXGDKVRISKARRTFDKGYLPQYTDEIFTISKRIARTPPVYKLKEANGDEIIGSFYEFELAKVIKDDDVYEIDKILKTRGRGAKKEILVSWKGYPASYDSWILANXIENKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H925</accession>
    <name>A0A6P8H925_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Transient receptor potential cation channel subfamily A member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116286531</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031548930.1">
        <property type="nucleotide sequence ID" value="XM_031693070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H925"/>
    <dbReference type="FunCoup" id="A0A6P8H925">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="GeneID" id="116286531"/>
    <dbReference type="KEGG" id="aten:116286531"/>
    <dbReference type="InParanoid" id="A0A6P8H925"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="925"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="716"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031548930.1"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125615" checksum="F0800FB98B2A8CFC" modified="2020-12-02" version="1">MSQKSKLVNDNGSISLNNMELTQNGEVNEGLDVKYEERQRKLTRISMGSDSEEPKSNELEELEEDNDVYKSKAQKLNEAVMTGNVDALSRLLEQKSIDVNMPDSYGRAPLHNAILRSDVRMVEMLLEANADINLKDDREDTPMHFAARSGNTKMIKVLLSHPECDVNVKGSSLNSPLHLAACQNRPALCKLLVERGAKINSQEENGKTPLGRAVETGANESAQYLLQYMTNEGMDIMEQLYDADYDGTTLLHLAVDSGFLEVVKLCVEYGAIIRQPRRKDRMTAFHLACEQGSVNIVKFLVEKDNTIAKILLVDSEWTTPLHKTARSNSHGIAEILIDNGAEINARDINNSTPLMAAAKTGATETVQLLMVKGADPTVKDVDGKTAVFNGIGHSKITEILLQDPVLAPLLTEKDNSGHTVAHYAAMKNDVKSMALFLKHNKAVASVTSDSLDTPLHVAAQYGNHEVIRVLIEKQAGKLINAQNNRSRTALHLACRGGHYRAAMLLLQNSAGVEKDQSGRTPLHEAAKNGAKKVVEMIVEKHIHCLNYVDEDKNTALHLAVIHCRAPIISFLLSLPRQEILKNSSNQNILDAAMCIENPIGAMTIAEHPRWREVLESCTTGVHKIFKLMVTKMPDVAERLLDNCIETEGDKSNQEYKIRYDLGILLRKRDPNDKSSLEILQHIADNRCEKCLTHRVSFIALCEKWNSYGWIAFLLNICCVLIYLIPMTVFHSFLKNNDETYCSDRINYTASGSIVYLDVQTCVRRHMDMQIYQIVLVVVIVVLHLTVTLFRMYRQKLAWLTSPTNIIELVAYLAALISLLPTCECKWGIQKEAAATGLFFGWINLIMYLQRLPFYGKYVIMLYRMFITLIKVLLLFGLFVFAFGTTFHQMLTEEPFNDLSTTMMNMFIMTLGEINYVDVFMPWNKLYYPFLANLVVVMFCLTMPIILMNMLVGLSVGDIDKIEQTALIDRYVLQVTLLNSIENSLPSWVLKRIQKKVVTIYPNKRPFRSVIFDALIGFGKVEEIEEEKNEEVEDLADSVKELHYKVEEHAQTMDEMKVMLKEMLDMMKQVELEKKVKVKRESIAVPALSISGLTGSLGSAFSFGLGGTKKTEAEDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9Z9</accession>
    <name>A0A6P8H9Z9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionine adenosyltransferase 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Methionine adenosyltransferase II beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116286874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549320.1">
        <property type="nucleotide sequence ID" value="XM_031693460.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H9Z9">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="GeneID" id="116286874"/>
    <dbReference type="KEGG" id="aten:116286874"/>
    <dbReference type="InParanoid" id="A0A6P8H9Z9"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031549320.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="34980" checksum="8AB78CEC75A82D2A" modified="2020-12-02" version="1">MADSRRRVLITGXSGLLGRALMKEFSRSPTFEVLGLAHSRISGNLKKVDLLDFEETGRVVADFKPHFLIHSAAERRPDVVEKDELXTQKLNIGTTEFLAKLVEGFNKGLEIQKHFLLYISTDYVFDGSNAPYKPGDQPNPLNKYGKSKLEGEEAVKQHHPNGLILRVPVLYGEVEYLGESAVTVLLSAIKDQKNPTVIDDYQLRYPTLVDDVAKVCHFIAEKKLEEPSLCGIFHWSGQEQMTKYGMVCTMAQLFGLPMDHIKPNKNPPTGPTIRPYNTALDSGKLEGMMGDRKSSCRTSFKEGIEKXLKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA85</accession>
    <name>A0A6P8HA85_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289685</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552496.1">
        <property type="nucleotide sequence ID" value="XM_031696636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HA85"/>
    <dbReference type="GeneID" id="116289685"/>
    <dbReference type="KEGG" id="aten:116289685"/>
    <dbReference type="InParanoid" id="A0A6P8HA85"/>
    <dbReference type="OrthoDB" id="5980047at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028035953" evidence="2">
        <location>
            <begin position="27"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552496.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24345" checksum="4CE0E414812DFB32" modified="2020-12-02" version="1">MMAGKTLFYWISVFLFHFILYPVACAQHNTTTSSLPPPPPPTTTTTQASPSVRSTALQAKATPSVPTAIPSIFITLSFDISWKKFCPLSEKFRGKFSTHLIEQNKDKIIHIISAARICYLNVDRYCAGDYNGEEKAEVELYISKRGEFCVVDEDMTTRAYRILHDYVVNKKMSKIDAVFADKKAYLRKSTTRQEIQAIRPTEHELQVLRPTEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAY9</accession>
    <name>A0A6P8HAY9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein Nkx-2.2a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549660.1">
        <property type="nucleotide sequence ID" value="XM_031693800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAY9"/>
    <dbReference type="GeneID" id="116287155"/>
    <dbReference type="KEGG" id="aten:116287155"/>
    <dbReference type="InParanoid" id="A0A6P8HAY9"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000101">
        <property type="entry name" value="NK2 homeobox 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF82">
        <property type="entry name" value="HOMEOBOX PROTEIN VND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549660.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24439" checksum="58E4E612C5816F2F" modified="2020-12-02" version="1">MSSFSIRDILDLPEDTIRSLQAIKPHMGMSSCTITDQCNMEASPNSDVDANEHAVDEAPISDDVPAEQGETRLSIYEKPEETKRETEIPKKRKRRILFTKAQTFILERRFQQQRYLSAPEREELARIANLTPAQVKIWFQNHRYKFRKQMSEKGHWDKPYISGPFLTGSGQYCSCVGPTCSYLTSSPYQPSPDYLHYPSPVNSTYLQSSSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBH6</accession>
    <name>A0A6P8HBH6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="12">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC116290815</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17 18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
            <location evidence="2 12">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The WWE domain mediates non-covalent poly(ADP-ribose)-binding.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Ubiquitinated; autoubiquitinated.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031553788.1">
        <property type="nucleotide sequence ID" value="XM_031697928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553794.1">
        <property type="nucleotide sequence ID" value="XM_031697934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBH6"/>
    <dbReference type="GeneID" id="116290815"/>
    <dbReference type="KEGG" id="aten:116290815"/>
    <dbReference type="OrthoDB" id="10065815at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16546">
        <property type="entry name" value="RING-HC_RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044110">
        <property type="entry name" value="RING-HC_RNF146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033509">
        <property type="entry name" value="RNF146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13417">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13417:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="15">
        <location>
            <begin position="115"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="183"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031553788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031553794.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33276" checksum="2B18FF637B35855B" modified="2020-12-02" version="1">MAERIERSSPQEDSSSSTKNDLNESPNPQNGEENDVEEQLLQDVVEVDSHPDCPVCLQPASYPVKLPCGHIFCFLCIKGVALRSRKCAICRQAIAADFLDKPTLVKVSTKTELPSETSCQDETENDYLWYYEGRNGWWQYDDKTSREVEAAFKNGKRSCTLLIAGFLYLIDFENMFQMRRNEPGRRRRIKRDKRDVDSKGVAGIRLQPSKPTTSNKQDTSLSSPSSTTSDNPERNDNEISAERVANQNCETTRPDTSDGASFLSDDQGGASSTSGAKDSGSPSRDVDSVITSFESTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDG3</accession>
    <name>A0A6P8HDG3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sperm-associated antigen 17-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553103.1">
        <property type="nucleotide sequence ID" value="XM_031697243.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HDG3">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="116290237"/>
    <dbReference type="KEGG" id="aten:116290237"/>
    <dbReference type="InParanoid" id="A0A6P8HDG3"/>
    <dbReference type="OrthoDB" id="5973991at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026173">
        <property type="entry name" value="SPAG17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963">
        <property type="entry name" value="PF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963:SF1">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1534"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1551"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553103.1"/>
        </source>
    </evidence>
    <sequence length="1572" mass="173428" checksum="330A259E2B773873" modified="2020-12-02" version="1">MQLLEETRYILPYVDTYYHKRDHSLLVAFHNPLGLQAKSQTSWQTKLHSNVGFRNYLDHVTSSIQSWVDEQERIKIEAARTPTPPPIVVEEPPPTLKEGSRYGLMTRSEVNALKAEEEEKNKKGKGKKSARSSRSPGRRSAKSRGGKDESPEKKDKKREGSSTSRPKSGRTSSAKGSLSVKSSSSKHDKKGGRSKSRTSCQDDTEEDTSSQPIEPSVEEHYDFIGYNVGDKLIHASGSLTTLFPSDGGQIRVDKNSYVQGAKNVRVSVLKDGNVFVLHFVDPVGEILPQEDTEPEGIKIKEENNQESKEKHDDEGIEKSEIEGNEKEQKELSKKFHKGPKPFCDFSSFVAQFNDGMILTHSGYGPSGSIISKELKETEAQLISSIVVPEGGGAAHGTPSPQPKAGSPKSRKKMDEEIKRMEELQQQQEEEKARLEEEAKKREEEEKNKKPFQNLFITCPDGLHLDYFNDGTYLSALDKGGVAVRQRYPIKGLGKQECEKPRQKPAMEEVSRTVLTNGTVIKFMKDDFVQVLFPDGGISSCQSFPTTSTSSRPTSQPTSTIVPKQPEISPTKKGLRATSSQKSSEEPPVPTLNVPEKVAQWVSTGIGGARVRTKEDGEVESLDGVLFSLATCPESGQVLRTREDNVVIVERPDGTLIVEHADGTRITTFYQELQTQTQVPDNETGEEALYKTINGKFVRVECPGFASLTFNCHEGSCGTVFGNGVYMETLANGVTTVERVDGSQLHIDATGVVSFAPRELTGKIDLSIPAPTNQPTDIPAGVYVMRSTQQNCCETKDIRGTHFSVASNGKMSIDKKEPQEVKDDNGATTEKKIESTHIERAVPQTTLVPRYFIIHSDGSGSELLRHADVREFLSRAEKDPATAVLRSPVEGDHEATGVTILKPYAGGISKEWFLQKIEDVIIPGALRERDFTAFPARHEKRPGPVFGTNVGAGVNVGTIIKNKPSIPPITCPPAFEFRQLIEYKRLTDDQRQQIVTCMKEYSEYVTKRQEKLDAILPQDPRDESEKLIAEKLDLKMTAAEKEVKEESDSKDVDSHPEEKEPEPGEEKAEIKDGIKEVIDSMSGKIQGESVGQQYVDAITPAPVPRPPPPRWKRSRSEWERDKIELAELEYGKNALKNHEVPPYFETARGQEFLHRAYDNLPDLDTLTSRLAEQTRHPPPGEGSASETSRSDSGGEELKQKFTQEFCSPEIAQVTNASANNENESSPSANGNTLSPNNLRPTNPTPAHATGDGTPTPLRPNNPTPAHASKPSNPRPSNPTPKHAEGQREELESSNDASPVFEEQQQWRSNLESVREIESTHDEQHDGIVTQSNNSSENSEVITDTPGNPKVGAKSLYMDVTGGVRKDKVKLPTSILSSKPGALLNSQFLETEDPVRRRVHTVSVAGGNKISPGRVEALRGFEMFPPKVSFGVLKEGCTYIHSVIMKNVGIDSCRFKIKQPPLSTGLRVLYNPGPVAAGMNTKLDIEIFAVAVGVVGDSGVGQIGHHVEIVTETDVIYLPVYATIMTAYEYENRYGDQDSGLTNGTNRVPNRPPSRDPTRPRKSVEYALINQETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDK5</accession>
    <name>A0A6P8HDK5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Titin-like isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116288075</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550655.1">
        <property type="nucleotide sequence ID" value="XM_031694795.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HDK5">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="GeneID" id="116288075"/>
    <dbReference type="InParanoid" id="A0A6P8HDK5"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
        <property type="entry name" value="Muscle M-line assembly protein unc-89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000147">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="55"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000594">
        <property type="entry name" value="Myosin light chain kinase isoform-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000145">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000714">
        <property type="entry name" value="Titin novex-3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="103"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056701">
        <property type="entry name" value="DUF7799"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056804">
        <property type="entry name" value="Spectrin_SESTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF7">
        <property type="entry name" value="TITIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7799"/>
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        <property type="term" value="C:neuron projection"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12726">
        <property type="entry name" value="RRM2_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000008">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000001">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000009">
        <property type="entry name" value="cytoplasmic polyadenylation element-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF12">
        <property type="entry name" value="TRANSLATIONAL REGULATOR ORB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="360"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="468"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031551327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551392.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="68134" checksum="39D928B23D5F5884" modified="2020-12-02" version="1">MADFGQNTRSLSPVDFKHNESSRATSLFFPTSLIDEQNGNKSDNKNGVCEDCIDDSSKSKANSTQSQTTTLGQKKLSFAGENSMFHDFPTSTTFWSPASIDETFVQPGGIPPVNGVHFSSNTQMLGSPRRPVAAPTVTTTINQQHRRPLQNSSQYIAQPKPMPNINSLASGWNGSQPNSMSGWPQQQPSTTWGRNYSSPNNALLNHGRNSRPSSLTFPQSSRLRSNGGSRSSYTSNSVSRHGISTQTITQGLQSLNLNGQHPIDGTILDNITGLGNSHGSNNELSNSFYSYQDSMKFPSLETRLLDIIRSPSDPPDNLAAFRCQLRKKGSHQGDQIVPSLGSSLNCSPNSDPEYIPRFSRKVFVGGLPPDIDEDEIHASFCRFGSLTVDWPHKAESKSYFPPKGYAFLLYLEEISVQKLIGACFRQDDKLYLCVSSPTIKDKPVQIRPWNLSDADFVMDGSQALDPRKTIFVGGVPRPLRAIELAMIMDRLYGGVCYAGIDVDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQLCDECHGARCAGKFAPFFCANVTCLQYYCEQCWAIIHSRAGREFHKPLVKEGADRPRTVSFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG91</accession>
    <name>A0A6P8HG91_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Venom phosphodiesterase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116288875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551600.1">
        <property type="nucleotide sequence ID" value="XM_031695740.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HG91">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="GeneID" id="116288875"/>
    <dbReference type="KEGG" id="aten:116288875"/>
    <dbReference type="InParanoid" id="A0A6P8HG91"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF114">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="11">
        <location>
            <begin position="555"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="10">
        <location>
            <begin position="556"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031551600.1"/>
        </source>
    </evidence>
    <sequence length="797" mass="90312" checksum="9DEB9D0C3900E714" modified="2020-12-02" version="1">MSKLKDSTLVLESDDSRAHIYKVKVDQPTILSKRKMLLLGIGILAIIMIIIVVVAVVVLALKAXDEQLGKIRYPVILISMDGFKYSYLGRGTAPNIQKLAKNGIRAKFLQPQFPTKTFPNHYSIITGLFPAHNGIVGNSFYDPTLKDTFKIGGKSSFDSKWWKGEPLWQTAMKNGLVAASYFFVGSEIPIKGMRPNFTMYYNQSHPFEARVEKVLQWLDLPVRGSHGKRRPDFITLYFHEPDSSGHRYGPDSPEVDNQTRYVDKMIGMLFDGLEERSLKDKVNVIMLADHGMASTNCSAKKXTYLDEYDVTLNDIFSLQKYGGPFMSLSPKXGGSLNKTEILSRIQCKSRYMRVFAKEELPKRLHYSYGSRIGDIIVISEDGWLVGTNSSLPCYRNIGYHGYDPMAESMRALFVAYGPSFKKGVVVDHFSNTEIYNMIASLLDITPAPNDGMPGSLQHLLSSTVDAPKPILQGDGKLFDQETCKYPGKNVAAERRDCRYCVCPYCDLKRDSSKLKVEELDDLLDLTSKQVSQYQRHNLPWGLPQGGAGEGGCILNQKEYINGFSTYLRVPLWVGYRLDGEKAGQRIPRQNCFRHDVRLTYNQTSTCTHFYKSGMDRGHLVPNADFDYNATAALNTFILSNIVPQYYIFNRGDWANLEDYVRDLAINFTTVYVISGSIFDKNADGLRDEDKSVSRWIKNQVNTVAIPTHFYKIIVRCDETKTPYYEVPGCDGRLDVMSFXLPHNDKGHCWFQNFKEYLLDNSATVRDIEKLTGSTFFSGLPPLEQARLKTFTPVELWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGP6</accession>
    <name>A0A6P8HGP6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 3B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555584.1">
        <property type="nucleotide sequence ID" value="XM_031699724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGP6"/>
    <dbReference type="GeneID" id="116292406"/>
    <dbReference type="KEGG" id="aten:116292406"/>
    <dbReference type="InParanoid" id="A0A6P8HGP6"/>
    <dbReference type="OrthoDB" id="2020019at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF172">
        <property type="entry name" value="LEUCINE RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027729544" evidence="3">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555584.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12299" checksum="A963B7AD31CD18A4" modified="2020-12-02" version="1">MVSTMKVTFLILVLWSFAFHIEARCGLVNCICSTNEYLQKTMTCRNISSIPDNIPTDIQKLDVAENSIENITSEKFENLTALSILTLSRNQIRHIYPGTFKSLTAVTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGW6</accession>
    <name>A0A6P8HGW6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116291989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031555086.1">
        <property type="nucleotide sequence ID" value="XM_031699226.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HGW6">
        <property type="interactions" value="1909"/>
    </dbReference>
    <dbReference type="GeneID" id="116291989"/>
    <dbReference type="KEGG" id="aten:116291989"/>
    <dbReference type="InParanoid" id="A0A6P8HGW6"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031555086.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42318" checksum="02CC89548BE0A284" modified="2020-12-02" version="1">MFSFRAVRSINLRKAGKVIVGFGXSVAGVGTIANFTSLSAREKTLQELSAGFMAAPLSKGLDDTRDTMRTRMELMILKAQGDICRKLAEIEGDSFIVDRWERKEGGGGISCVLQDGKVFEKAGVNVSVVYGILPDKAAQQMKSRGKEFKGSDLPFFACGISSVIHPRNPMVPTVHFNYRYFEVVDTDGQKHCWFGGGTDLTPYYLNEEDGKHFHGVLKKTCDKHDPTYYTRFKEWCDKYFFIPHRGESRGVGGIFFDDLEKPSEEKLFSFVEDCAASVIPAYIPIVEKHKDDPYTDEERHWQLIRRGRYVEFNLVYDRGTKFGLYTPGSRIESILMSLPLYACWEYMQTPEEGSREEKVLEVLRKPREWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIB0</accession>
    <name>A0A6P8HIB0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Trace amine-associated receptor 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116289558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552367.1">
        <property type="nucleotide sequence ID" value="XM_031696507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIB0"/>
    <dbReference type="FunCoup" id="A0A6P8HIB0">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="GeneID" id="116289558"/>
    <dbReference type="KEGG" id="aten:116289558"/>
    <dbReference type="InParanoid" id="A0A6P8HIB0"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031552367.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40494" checksum="3D725B8C3596178E" modified="2020-12-02" version="1">MNGTECPGSDRSISFIILAVLSSLSGLVAVTGNVLVLLAIYTTRSLRTTSNLFIASLAASDFLVGSVMDPILAVRSIKYSYFGVSFNDKNPFKKGVDFLWIQAVIATTFGLLAVSVDRYVAITKVFLYDSMFTSHRSGYLITFIWIFSFVFASLRLFLPDSKLALLWVATAILSCGIPFTVTAYCYLAIFKAARKQLRRIVNETTAKETRRLEEARHRKTAWTIGIVIALFFFLWFPSLVIASINLTLEQGCKKENFSRTVWIWVEWVAYMSSAVNPWVYSMRSAEFRIACKQSLGLQKTRIIPEEMISRSRARPSVIDMGTSNPSPGNIKDSQIRISPCNDPVNKQSKFKDCNFLLPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIN9</accession>
    <name>A0A6P8HIN9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116292514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555716.1">
        <property type="nucleotide sequence ID" value="XM_031699856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIN9"/>
    <dbReference type="GeneID" id="116292514"/>
    <dbReference type="KEGG" id="aten:116292514"/>
    <dbReference type="InParanoid" id="A0A6P8HIN9"/>
    <dbReference type="OrthoDB" id="5965981at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555716.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47799" checksum="13DA974574123F2C" modified="2020-12-02" version="1">MENSSLSGSSSGNQLQVLQDIVEFLEGIEQSVELLKSKINSLSAKYPITAQEKRLNQLIEKIQRDVQERVAMEKLLRETTMSVEESTTPSSSVGTEESFPIPSPPQEVDYPVILYNSYCLRRRTVDQVGKLGQTLPRKKKVKVMGINVETLTNDKYDREKRAGEWTKELVTVLQNGQDYKTEKLDSENVAPNAQAIVLDIGKTNFKKGSIPIFFFESQMGDLIVSPEKIFLSPKEYAQLRGYDPNERLEIAMKVAAANYEYWSSVYYKGLRNKEKDPMQQSLVKEYLRHYIKDPLNSKGLIFYYQINKSCCHQQIQCQSYIGKCEGSLVEKLREIHEESDQEKPSLLKLALKSKLLYSEENEVGDIAKKNVVLILDFGYTEEFVEKYKDRLDKGDRLSVLQKNYVEYFGARSPIGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK94</accession>
    <name>A0A6P8HK94_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556794.1">
        <property type="nucleotide sequence ID" value="XM_031700934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK94"/>
    <dbReference type="FunCoup" id="A0A6P8HK94">
        <property type="interactions" value="1960"/>
    </dbReference>
    <dbReference type="GeneID" id="116293499"/>
    <dbReference type="KEGG" id="aten:116293499"/>
    <dbReference type="InParanoid" id="A0A6P8HK94"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556794.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48846" checksum="5F893CCC13E25B8E" modified="2020-12-02" version="1">MSGTCDSSGLEAKLEKLDISQTGDEKPAQVKKRAGLVYDERMKKHANIWDKDHMEVPDRLGRPYNKHIEYGLLERCYRIPSRFATEDELSTFHSKKHIDKMKSTQGMKTRDLFNLGEEYDSIYMSEVSGQLRTDVKPKEFLTQLGDKYESDYMSEHVYECALLACGCTLEAVEHVATNKVQNAVAIVRPPGHHADTDSAMGYCYFNNIAIAAKIAQQKWGMKKVLIVDWDIHHGNGTQSLFESDPSVLYFSTHVYQHARFYPFSTIANYDVVGEGPGKGFNINVPWNKFHMGDADYLAAFQHVLLPIAYEFDPDIVLVSAGFDSARGDPKGHCDITPEGYCHLTNLLMSLAGGKVVIVLEGGYNLTSVEESMCSCTSTLLGDPCPRLEGGSLVPSRSAMESIKNVINAHKPYWKCLEFVDVSIPDAEEKDEEEITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKX6</accession>
    <name>A0A6P8HKX6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557044.1">
        <property type="nucleotide sequence ID" value="XM_031701184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293719"/>
    <dbReference type="KEGG" id="aten:116293719"/>
    <dbReference type="InParanoid" id="A0A6P8HKX6"/>
    <dbReference type="OrthoDB" id="10306650at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557044.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36274" checksum="055C1F61B2EB3567" modified="2020-12-02" version="1">MARKRERSNKSQHMMGSKRRQVPINDIIFLGIPGFCCFPVRIEKYLGFSKMKSLLLAVLLILGANCISKLAGYDSSEKSEAPAIRKYNCDAVQDKKPWCACRSSLSSTIIDLSSLGTGDKNLNASIHPPKFRSINGVQGWFIAWSPCEDFDLFTNMTLNPDEKACKGVGFARYYTAGKICKGYESHENSAKFYSYGHDVKTGKEKFYIEFHFTTKVEVRTARIWLMCTQDSDKNILEYNGDRAGTEVAHFYSKCCCPNNLCGKSRNDPPKRYKLGTGAIAGISVAVVAVIAIIAIVMYKRKXHPFPIPVEIVAQEQDERHPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLG7</accession>
    <name>A0A6P8HLG7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Delta-type opioid receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555788.1">
        <property type="nucleotide sequence ID" value="XM_031699928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLG7"/>
    <dbReference type="FunCoup" id="A0A6P8HLG7">
        <property type="interactions" value="2156"/>
    </dbReference>
    <dbReference type="GeneID" id="116292586"/>
    <dbReference type="KEGG" id="aten:116292586"/>
    <dbReference type="InParanoid" id="A0A6P8HLG7"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="55"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555788.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45181" checksum="3439420F30E6641C" modified="2020-12-02" version="1">MATVNFSNCSWNATRSGNCSLLYPNLDNWPFPQSLASRVGKMCAYIIVAVLALLGNGFVIVIISRNKHLRKAINYFILNMAISDLVTPLIIIPIQLYPLTVEHKKGVQLVWPFDGDFGSFLCKLSMFLADSSPVVSIMSLVFMTVDRFYAVVFPLKAQRVSHKIRLTFLTISWIVGFGFFSPHFQVVHVVKIEDHFYCQLSFAPTFNHTKSMHIFFTTACVLFTIIPFILLTVMYSVMLLSLKKETIAHTRNVSSRRQKNNRKIVFMALVIVLVFAVCWGPYNGFIFVITIVWRWKLPRNLADKDLTTFSFVTHFLTCTNAALNPCIYFIFIQSYRSALKNLFCKEPKDSPKSILSLNDSNQWQGKVTKRLLTTASNTRPISGLKKNSIAGSEMGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM98</accession>
    <name>A0A6P8HM98_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A</fullName>
            <ecNumber evidence="8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116292930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55392"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031556138.1">
        <property type="nucleotide sequence ID" value="XM_031700278.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556139.1">
        <property type="nucleotide sequence ID" value="XM_031700279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292930"/>
    <dbReference type="KEGG" id="aten:116292930"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000227">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000002">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="64"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031556139.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38015" checksum="40EF40746294D75B" modified="2020-12-02" version="1">MSFSEYKDRISEGDTVIVFLGFNSMQSVIVSSKKVHQTKYGALPHADMIGKRFGSKMHTMNNKGWVYLLHPTPELWTINLPHRTQILYHTDISMAVMQLDIKPGSVXVESGTGSASMTHALIRTVAPSGHVHTFEFHQERCEKARKEFQEHKVDHLVTIEHRDVLKDGFQLDNIADAVFLDLPCPWDAIPTSKQAFKKSGGRLCSFSPCIEQVQRTCEVLTKEGFKDIQVMECLLRSYDVKPVTIQEADFGPTVPQVSEKGNNSHNKKRKLEDTEDTVPEGENSDSNGNKEPTDEEKKTHQNYHPKVEMKTLMTARPVRDVPGHTGFLTFATLFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMW2</accession>
    <name>A0A6P8HMW2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Adhesion G-protein coupled receptor D1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553995.1">
        <property type="nucleotide sequence ID" value="XM_031698135.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HMW2">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="GeneID" id="116291012"/>
    <dbReference type="KEGG" id="aten:116291012"/>
    <dbReference type="InParanoid" id="A0A6P8HMW2"/>
    <dbReference type="OrthoDB" id="5962698at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000073">
        <property type="entry name" value="Adhesion G-protein coupled receptor D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028294844" evidence="8">
        <location>
            <begin position="31"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="9">
        <location>
            <begin position="203"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="372"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553995.1"/>
        </source>
    </evidence>
    <sequence length="667" mass="75781" checksum="3D650688E558C097" modified="2020-12-02" version="1">MISSFFNSYTTAVICCFLLQIWCQVPRVISVFNCTHIGSFPHSQDPSKFYSCSTSSGPALVYKCPGKQIFNATIRFCVTFTPGTTTQKTPTSPISQAPSLPGRSKCFKRRLKSMIQCFKNDSMSWKRYLRSVSSSNDTNDILKKAVNNTDEIFSAFENERNSSQGFNAFDVLEILDDIGRYVANKTGSTTLTAYSDDIFIEISPIHLPYHFPNYSHNAFDLEQYRGVCDLIEFPKGLFKDSIAYHAVSTLYLGLMDKLXTRVFQSNKSYVINSHVISSLIVPNIFTPFEKNIIIILKHVRALERGDYSICAYWDYSLRTNQGYGAWSREGCYVMTGRSNKTHTTCSCNHLTNFAILMGSENIPITKTHEFALSVITYIGCALSLFGSVTAIAILVVLTSGLHSDRNIIHANLLISIAISQTVFLAGVEQTQDRTRCKFTAIMLHYFYLVSFAWMLCEGFHLYAMVIKVFNLTSRVYHYVAFAWGIPAFIVLITVACRFKEYGTPSSCWISTEYYTLLAFILPVTLTLLVNIVILCLVMREICKLHVSESSHIKKMINSTFKTVAVLFPLLGITWIFGLLLFVTQQIMFQYLFAVFNSLQGFFIFVLHCLFNSEIRKNFKRKKEVWKSLRAFENVRRRITISIIPVRSPVTKATTVSNERAETFEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR34</accession>
    <name>A0A6P8HR34_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294149</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557553.1">
        <property type="nucleotide sequence ID" value="XM_031701693.1"/>
    </dbReference>
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        <property type="interactions" value="1771"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:spliceosomal complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557553.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10734" checksum="A4DC23D549D932FC" modified="2020-12-02" version="1">MAYKGQKVQKVMVQPINLIFRYLQNRSRVQIWLYEQVNMRIEGHIIGFDEYMNLVLDEAEEIHLKSKTRRPLGRILLKGDNITLLMNATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR53</accession>
    <name>A0A6P8HR53_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel subfamily A member 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116294172</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557578.1">
        <property type="nucleotide sequence ID" value="XM_031701718.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:delayed rectifier potassium channel activity"/>
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        <property type="term" value="P:protein homooligomerization"/>
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        <property type="entry name" value="Potassium channel"/>
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    </dbReference>
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        <property type="entry name" value="Potassium voltage-gated channel protein shk-1"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000053">
        <property type="entry name" value="potassium voltage-gated channel subfamily A member 4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
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        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
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        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
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        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02214">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="103"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="478"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557578.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="66122" checksum="4B4FC37D2AB80563" modified="2020-12-02" version="1">MYASLANAQEFQDHGHGQQSRNSILRSLYHPDGNGLLYLTERRSDMDAISGVPSLTAVADKKSSLGCNTDGRNNSHVRAIRGDQMPNNNSTISYSTAVPDTTDRIVINVSGLKFETHIQTLEQNPDTLLGNEAKRAKYYDGIRNEYFFDRNRPAFDAILFYYQSGGKLLRPANVPMDVFADEIRFYELGEDVLHKVEQEEGYIEEEKPILPENKFQRQIWQLFEFPDTSLAARFVAIFSVVVITLSIVTFCVETLPQFQKKKEQDMAGSINGTRAENERYDQPWFSLESACIVWFTFEYFMRLISSPQKLVFVRSFLNLIDIVAIMPYYITLPMQDTKASSLGVLRVIRLVRVFRIFKLSRHSRGLQILGHTLRASLRELGLLIFFLLIGVILFSSAVYYAEGGEKGTHFKSIPDAFWWAVVTMTTVGYGDMRPITVWGKIVGSLCAISGVLTIALPVPVIVSNFNYFYHRENEQRAAEASKKEKEKKEAERKLKEEQEALQQQEQEEHEKPPYITNQWGVKPQYEVIDQNGMNGPDVIGIEMEDVNSVRKASGIKANTAVVSNSLPTVEYSDAKLRYETGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR66</accession>
    <name>A0A6P8HR66_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein O-mannosyl-transferase TMTC4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116294580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558071.1">
        <property type="nucleotide sequence ID" value="XM_031702211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR66"/>
    <dbReference type="GeneID" id="116294580"/>
    <dbReference type="KEGG" id="aten:116294580"/>
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    <dbReference type="OrthoDB" id="19588at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="5">
        <location>
            <begin position="110"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031558071.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31542" checksum="BDEF69601F729203" modified="2020-12-02" version="1">MFRLFTKSSQGTNSQAALGYLLTSVTLCSLAMLFKEQGITVLGLCCAYDIVMFCKIDFIQLIKKLFKPKKPASTTEDNGVFLFRGLIFRQSILVLVGIILLLGRWKVMGSTPPHFQVSDNPPSFEKSFVSRFINYNYIYTINLWLLINPWWLCFDWSMGCIPLIKEPTDPRVAAVLLMWAVLFTLFGYCILGQPSHYKRICTMGLAFLIVPFLPASNIFFRVGFVIAERVLYLSSVGSCILVVLGIAALSRRAYLRKYVACCMFTMIVCFTLWTIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRC9</accession>
    <name>A0A6P8HRC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295288</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558929.1">
        <property type="nucleotide sequence ID" value="XM_031703069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRC9"/>
    <dbReference type="FunCoup" id="A0A6P8HRC9">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="GeneID" id="116295288"/>
    <dbReference type="KEGG" id="aten:116295288"/>
    <dbReference type="InParanoid" id="A0A6P8HRC9"/>
    <dbReference type="OrthoDB" id="5983623at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558929.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34366" checksum="53370172FF8C8059" modified="2020-12-02" version="1">MIRIRKMELEVVLIVLCVLVVITNMAVICMVVFIKELRTFTNYFVLSLAVSDVLVGGIMLPLNHPWVPSSEVTGHVIMITMLSGVGNICAVTWDRYVAVMEPFTYRTKLKRYYKKILIILWITAITCSLIPLAWKDEDTSIYHKVYYVMTILGFVILPYLAIIIGYVRIYARLRYHTAQLKSEGITRSKREGAQRASLEGKTVKVFVVVVVLFLLSWVPVIYMTMVDGVFQQPNLVPSLLQRFNLLVLAVSSLVNPLLYGFMKRDFNGQIKRCLCCLKTTPAVHALAMETTPVRACAENSAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRQ2</accession>
    <name>A0A6P8HRQ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292206</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555330.1">
        <property type="nucleotide sequence ID" value="XM_031699470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRQ2"/>
    <dbReference type="GeneID" id="116292206"/>
    <dbReference type="KEGG" id="aten:116292206"/>
    <dbReference type="InParanoid" id="A0A6P8HRQ2"/>
    <dbReference type="OrthoDB" id="5948245at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555330.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="60574" checksum="50BE35D126EA4112" modified="2020-12-02" version="1">MEVKASILSLNDDCLCNIVAFISDRSSFNSLARTCKRLQQLTSNPRNCHVDIVRLRAEHFIKRLVVHLGANHDKRGLSYEAYDEFCKFEEFLAQAFQYSSTRCLLTYDKVVDVWITSGPVASEVFTWVRNHSFSVSEGEPRATCMTKYSSFTVHLPRRNREMSVNTTYFHDHIGNYDDELTIEVKCDDLKIESKDFYRISPEDFKYWSEEEMKQVVESMKPVTDLLQEELGETIPSIHGNFLFWFLYFFPEKMRFDEEDKLSFKDAAKNEKPSIESIQPMLEYFQKNLLREFQTSSARWMKEKAFPEETETCKFVIESLDALVQRSDARFLKNIQRSISRIFRVITDYCLRKLPEKLMLALIKKTSFETDNFSSGATADKFVDNTVSFQLPESKFIKVKGEIEGDGYSDPTWHRLKLEFHLPDKKIHLDSGNIYDRRSREEKKLDMGKLSPVTKLLQECINHSMEGEEEIPKIKDMFTALYFIIVLDFGILRKDNFFGDSIDLSDLLMEAEEDKLSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS12</accession>
    <name>A0A6P8HS12_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cyclin-dependent kinase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116294472</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557933.1">
        <property type="nucleotide sequence ID" value="XM_031702073.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HS12">
        <property type="interactions" value="1990"/>
    </dbReference>
    <dbReference type="GeneID" id="116294472"/>
    <dbReference type="KEGG" id="aten:116294472"/>
    <dbReference type="InParanoid" id="A0A6P8HS12"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="8"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031557933.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34189" checksum="27FA1BC5AA5C787B" modified="2020-12-02" version="1">MSNSMEKFERIEKIGEGTYGVVYKAKDKTNGGMVALKRIRLDAESEGVPSTAIREISLLKELSHPNVVSLFDVVQSVNSLYLVFEFLTQDLKKYLDSLPASGMQLPLVKSYLYQLLNGIAFCHSHRILHRDLKPQNLLIDKNGSIKLADFGLARAIGVPVRSYTHEVVTLWYRAPEILLGCRYYSTPVDVWSIGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDNDIWPGVSELPDYKTTFPKWPVQSLENVIPSLHDPAIDILQKMLTYQPDSRISAKLAMXHEFFKDVQRNIILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS38</accession>
    <name>A0A6P8HS38_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cohesin subunit SA-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555517.1">
        <property type="nucleotide sequence ID" value="XM_031699657.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HS38">
        <property type="interactions" value="3734"/>
    </dbReference>
    <dbReference type="GeneID" id="116292354"/>
    <dbReference type="KEGG" id="aten:116292354"/>
    <dbReference type="InParanoid" id="A0A6P8HS38"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="4">
        <location>
            <begin position="373"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1200"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1264"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1355"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555517.1"/>
        </source>
    </evidence>
    <sequence length="1364" mass="155489" checksum="691DE41F3FF3C0BD" modified="2020-12-02" version="1">MPALRTRKEDETVSPSEASSPASGVTPASKVKEAKDDKNDSPRRSGRKYKQRILFGHEKIQPTPSPSASKKTKLPKKTVEKPDSDEEQEEQEESSSDEEVPESNSEEEEVVTPRKATPKGRKTTPATPKTNPFGKKGRTPSRATPGRKRKGKATSQDDDDQGTLFDIVKAGKGALRAVVDDWIESYNKDKEAAMVDIIQFFVQCCGCKGTVTSSMLDEDENVDAVRQLTEQFDEESHEYPLIMSGPSHKKFKTNFIAFVHTLVVQCQHSIIYDEYMLDTLVSWLIRLSDSQVRAFRHTSTLAGMKLVSALIHIAKNVHIELDNTQRQLDSETQKSTSKKALEKIDMLQTRRQELRQNINDLEEMMNFIFQGMFVHRYRDSRPEIRALCISEIGEWMKEYSTLFLNDKYLKYIVWNLHDKVGEVRLKSLQALLGLYGDEDLVPHLDVLTTRFKDRFVSMTLDKDNEVAVEAVKLMIHMYQYDKLDEEDCQQVQLLVFCTHKQVAHAAGQFLYKRIKDAAEEDIKPNKSKKGSKKSDKETKAVQLKKLLEFFINSEVHNHGAYLVDSLWNTASLIKDWKLMTDMLLDKADEAGLDDKEEEALIEIMVSSCKQSSQGQGPPGRVVRKLLSSKEKKTIISDKKELSAHFMQTVPDLLAKYGTDNEKVLSLVSMPQCFDLEEYGQRRLGKYLEELLNQLDSVVEKSTDPMVLQECAKTYRALTDSEYTLSTTAEVSRNKLVDQFVEAFKGSLQNGLNADDDDEDNNDRFVLISNLEKISAFYKAHDLGSWKLYDNLHHIMHHATTDQETVPDRILILTINAMQCLLLWTLTGLDANHPDKAQLKKLKKWSTTFIRQCEELVGYSNTEVRIEAFLCVCDLLIVFAKQLKNQSPLLGPLVYEPSDSFQATCRDFIVNHIFDNINEDEPEEEDDEQTDEKVEELSRKRTMLAAFLKLVIFNVFDMGLAAPVFSFLNKAFSDFGDIIKHAMNKCKEINKTTYVKTLLAALQQDFLNLKEEQEGEVDVKSEEFCIIKDLAHRFALSLGVDTTKSQAREALITLHREGIQYALSKSTGKKQSPKKGNIPPPNLPFFDILNEFTFRLIPQDKTGRSGVLPFLNKEAGDKVEMKGDEWNPLITYRNNLLGNQEGEEEHEPQKQDKSRSARGRPKKPPAPPPVQGKGKKRQASPEKEDEDSADDAVPLKRTKKMREDTEQSHVEPEREEKPEGDSGEESGLDEKNTKQQKRKRQDSEHSENPEEGEEDGDEDFDNSGVPSSSQKSWMASQTKASKRPRISYSKKDRDKVPHPRLEDDDDDEVGDEQNIEEYKSEEESEPKKKAPLRVRREKREIPENFFDSQENKSTEDDGTLDEPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSB8</accession>
    <name>A0A6P8HSB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Gamma-aminobutyric acid type B receptor subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116294588</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558078.1">
        <property type="nucleotide sequence ID" value="XM_031702218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294588"/>
    <dbReference type="KEGG" id="aten:116294588"/>
    <dbReference type="InParanoid" id="A0A6P8HSB8"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000072">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027877609" evidence="18">
        <location>
            <begin position="22"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="19">
        <location>
            <begin position="456"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031558078.1"/>
        </source>
    </evidence>
    <sequence length="789" mass="89148" checksum="EA74BDF23CF90BDF" modified="2020-12-02" version="1">MSTNKTIFVCLLSFLMECGFAPDAKQPLYIGSISPXTGTGKWWGRGIPLAAQMAFDMINIDTSILNDYELKLISNNSKGETGXGIRVLYGYLVNRQILMLLGPMRSNVATAVADTAKFWQLIQVSAAAXSGELSDSKKYPYFLRTXPSASAMSTAFIALAHKFGWTRVSILYYSREMQFQTASDLRKKCDANNITVSSFGSFSDTFDAHTQMQHIKDIDSRIIFGLLQLTTSVMCEIFKLKMYGRQYAWLIDTPDKHGWWQRTYKKTNCTQEEISEAANHVITINNMNISRSTKKGISGLTPKQFQDRYELYAKERNSIVSEYGTFAFDAAWLMALALNKTENELRPGRNLSQFYYKDRSMALMIXKNLIQTGFRGVTGTVQLQGNGDRYGHFEVSQIQDGILRVIGTHNVLTNNFTLDAGMDFIWKGGFPPSDRLIVVPRLIGFPVVGFIVICCIAVGGVILSLVFLYCNIAYRQKRFIKMSSPNINNLIIAGCIVAYLSVILFAVDGEHLTSLVCQVRLVTLNISFTLAFGAMFIKTWRVHRITRKIRNKRRVIQDIHLVGLVVIFLIIDIVILTTWLIINPLQXDYRWFDLKQDTKPSNSAVIYRQKIAYCRTTNVLLWLVVVYGSKALLLLFGLFLAWETRKIKISALNDSQHIGMAVYNVVIVCIVGVPIIQLLNDDMYEVSFIITTFCIMSCTTLTLCLVFVPKVRKLLKSTADEIFSDNGISFASRMESKRANCTCDCHVQDLVKKSPRILGSNAVKQKKQETKETNILDHRNIKTKPSYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV17</accession>
    <name>A0A6P8HV17_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Papilin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116295477</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559152.1">
        <property type="nucleotide sequence ID" value="XM_031703292.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559153.1">
        <property type="nucleotide sequence ID" value="XM_031703293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HV17"/>
    <dbReference type="GeneID" id="116295477"/>
    <dbReference type="KEGG" id="aten:116295477"/>
    <dbReference type="OrthoDB" id="10493857at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653101" evidence="1">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559153.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="10921" checksum="0F707B82A9597EE6" modified="2020-12-02" version="1">MASRIIFSIFLGIAFTYVVQAQLVVPGKCPDFPAPAECPPEPDDECRNDVNCAELYPGQGLKCCKDGCDKVCTQPAQPNQTKKQKSRSLKVINIDPSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVB6</accession>
    <name>A0A6P8HVB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559268.1">
        <property type="nucleotide sequence ID" value="XM_031703408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVB6"/>
    <dbReference type="GeneID" id="116295560"/>
    <dbReference type="KEGG" id="aten:116295560"/>
    <dbReference type="InParanoid" id="A0A6P8HVB6"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057873">
        <property type="entry name" value="CTHRC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25815">
        <property type="entry name" value="CTHRC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027671189" evidence="2">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CTHRC1 C-terminal" evidence="3">
        <location>
            <begin position="149"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559268.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30281" checksum="775C5E87CFAFFA63" modified="2020-12-02" version="1">MSYLLPSIAALILVMAQLIKTQSPDFNWGIYNCRELETKCLSYFFGPPGDMGQLGQPGIPGQDGLPGTPGPKGPKGYSGIGEPVPIAGPKGYTGIPGLKGIKGVRGNRGLKGEKGDSGSSLQGDKGDNGFPGFPGPKGFPGSGGMVLGWKSCSWKFDSLQEYGLTKECIFNKTHADSVLHVIYEGSMRVGFCTTCCKRWFFTFDNQDCQQGRIEAKLTGTKLYSGPSYRHERLEGYCAVAAGRTSVELWVEDCPGHQRAMKASIAKVDTTSRIIIEEIYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVX3</accession>
    <name>A0A6P8HVX3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC116293456</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116293456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556742.1">
        <property type="nucleotide sequence ID" value="XM_031700882.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556743.1">
        <property type="nucleotide sequence ID" value="XM_031700883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVX3"/>
    <dbReference type="GeneID" id="116293456"/>
    <dbReference type="KEGG" id="aten:116293456"/>
    <dbReference type="OrthoDB" id="5979767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031556742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031556743.1"/>
        </source>
    </evidence>
    <sequence length="861" mass="95700" checksum="6F8FFD875248B2B5" modified="2020-12-02" version="1">MADKDSLGPEALLRASSDCKYRLIRLLIEGGTLTNVRNENQETPLILACKSESEEKEKVVDYLIRKRVKVNLQDIHGRTALMHACLTNSSDNIIRMLVNSKANPWLVDEGNNTSFDYAINAGNIGAVKLMIQACREGKILTKPGSFNIEMKKLEDRLDEMPEIRKCSWPLMGPRISTGKEKRNTNQSNLLAVSEVDEFTESPTRERRRKRSICHFDPIGLEASEGSSEGESTTKPLRRASLASASRSASEDERISLHFSDSDNSSFDRSSTNFSSLEKLLRMRDSVTSSVDSTDSLNAQNLQIKVEGITEEESSKNSEIFAVAKCTRALDEMLTKEREEHSRKKINDNKNSKDVEKLNQSQTDLKYRSEKTGHSDGTQETCAGVDRKKKLSKEYEVQSTQIGQSRNELMKSSCALPCGMSAQNQESPRTPRRRTVGTSTPSQKGDVIEDWERKTTGNETEAMRRFTLGAMDLRSDDKRRSLNLWGEEHNLRPSPPPRDLSRTPITVVTSPEMKSFRKKIRSPEVDFSHGRGPFEHAQELGKKNGNENAGVHTTHNSAKGRKLDASKTELKTNAPLPFNLPVISPLDNIGWKGKEREGKESGKNSQVEKTAVRRTLSDSVSHERRRASASGTRHVHHSNGKEESSSACVIDSTAGTTKLVTRERSSSFTPLSTTASTTGTPPQERKASNVSPCCDIVTMATSSTGEPLRCHSPRNKLSSDLPDLVLHTPRSRGRSPSNLDPFSLAPELHVSDQYHTRYARSVPSSSETLNPTGSQSYLTGSHNHLPEVVSSTTGSPKQRRLAFLPPLNISRKQQDQPEEGYFSCSPSPLDVESSSRSKEKSKYSFKPPSPRLVNRPVKNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWR5</accession>
    <name>A0A6P8HWR5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116296873</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560839.1">
        <property type="nucleotide sequence ID" value="XM_031704979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWR5"/>
    <dbReference type="GeneID" id="116296873"/>
    <dbReference type="KEGG" id="aten:116296873"/>
    <dbReference type="InParanoid" id="A0A6P8HWR5"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560839.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="82714" checksum="EBCBFEFEE4426680" modified="2020-12-02" version="1">MFNNAQLKEHGELLNKSMDGENSSKFVKGLKQLNYQRSSGLLCLLDEEKNQEEEKNPGVEVKQNGVEDFEIKAKENGAEIRLQCNTNGGQFEQTSAAGTGLFDEVSKAFKKKRSIANKCKVYVGNIGYKVRSREFKEFFSAFGRVLQAQIVQDRIKKRSRGFGFVTYSNEYEAQKAKQSADEERTLHDRVMTVMTPTRKRKGGPVSKEQSLEEALEEFQNLSLLEEKESNENLDNEKGQLSISDLNDDILILIFSYLQLKDKIHIERVCTRWKCLLLKVWPSVTHLDFKNLFSLYKGGLTDDILLGIFRRGCKNLTSLDLSASPFLLTEFAVHCIAKHCKNLREINITGVEVSTSSLKTLSKECSKLEKLVLRRCYQAGEKGFWWIFKQCTNLKHIDISDNKRLSGKCFFMLSDTVESLILSHCSRLTDSSGAFIGTRCKNLKYIDISECLSLTDTGVRDIIQGCPKIEEFYFKKCPKTVTTHGLSVLSRLNHLVVLDLSLCDAVDDQILLLLGQSSIHLKSLNIEGCFGNITDTGLQALITCHTLETLNISYVDEITDVSISQLARNGSIQTFVARACSGLSDDVVRSLLCHCTNLTTLDMSGSINITDISLNHLTEYYTSSQRPVLTFIIGGTQITEKGVSDTCSPCHNNCKIDTFDLSSESLRFGNPRLQSIAPFLEESDEDDNDSDGEDEDNHIEQINYEMGNDVYQDFLEADDPALMMDEEYWMFDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXK1</accession>
    <name>A0A6P8HXK1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-1(XII) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557395.1">
        <property type="nucleotide sequence ID" value="XM_031701535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXK1"/>
    <dbReference type="GeneID" id="116294020"/>
    <dbReference type="KEGG" id="aten:116294020"/>
    <dbReference type="InParanoid" id="A0A6P8HXK1"/>
    <dbReference type="OrthoDB" id="5988949at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557395.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24318" checksum="4BA90FF7EEEF61F5" modified="2020-12-02" version="1">MQVFGRALSAAEIRMRMKTCFRPVPPVPPKPTRPPPTASPKVCNRRIDLGFLIDVSSRVGRTNIKYIRLYVKEMVRRFRVTSRLTRVGIVTYSSRQRRIIRLTRARSNRDVNRALGRIQIRRGRRRTGSGLRYAKRYLFEGKPKCGRKRVLIVLTTGASADGVRRPAKSLENIGVEIFVVVPNKGGRKQMHQIATSRLHVVTMAYARLINIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ71</accession>
    <name>A0A6P8HZ71_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116296675</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116296675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560591.1">
        <property type="nucleotide sequence ID" value="XM_031704731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ71"/>
    <dbReference type="KEGG" id="aten:116296675"/>
    <dbReference type="InParanoid" id="A0A6P8HZ71"/>
    <dbReference type="OrthoDB" id="5980942at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="D or N" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031560591.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26731" checksum="9202C3D4014B5905" modified="2020-12-02" version="1">MVVPTDDQSEEEVKGTILAIKQEWKKTRKDHGNIKEMMNRTYAKRREMVPIEQQPLKEIVNMFPPVQSMLYIKADFARVMGNPDLTTQMKSSFKDVWSCRTLSYAKKNSKHEKIFLEMTAVIDSGCQEEEFKERSALKLASMILRPPNRKGIQNKDHEEAVIKVIPDHQSLDEAIKGLRQPVIIVANDLYNSDLMYVAAEGMLFSTITTNKIADAIVGKNILFFRKNLNGCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZB6</accession>
    <name>A0A6P8HZB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294528</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558015.1">
        <property type="nucleotide sequence ID" value="XM_031702155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294528"/>
    <dbReference type="KEGG" id="aten:116294528"/>
    <dbReference type="InParanoid" id="A0A6P8HZB6"/>
    <dbReference type="OrthoDB" id="5990151at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031558015.1"/>
        </source>
    </evidence>
    <sequence length="1976" mass="225583" checksum="2CD3F60E97CE1716" modified="2020-12-02" version="1">MSRCLSKFRDMYEAIVRARMYFVVVASATQVYRENPIETFKVLFETLIPRIQDEGFEELIEQTVAITKRDENLDFFKLSRIYGVKEAIILSSWKDLLKVSFLRNWFVVEVAKHDFLVHDERYAPNLPFTDYLTYKESLVCEVADCISSLGSSLVEQKEVFCSKDRTTVFFDHSEVFLRHTSLCLQLMQSKEISVILIEKLFFTLGIKLDRALLPFPTNSDLEDCDFEISPDTDAMNAKLKSLKEQSRGRSAHKLMFERLYEKSSFDAITKALLTLPDKQLVLNVVQIWKQNFPDDTSKLILSQLLVLVKVVIEGEKDLESISSNMKQLVTFLSHLSPECLYNLSLWQPLMVHLIPSLPHSWYGPEVLSLILRLLDLHCRNPINDPSSGVAQKIRQIPNFVLISLKGASKSEEVKIKVLQLALELFEEVPLPEEYRFVLNVILSVASDMETNAIKTFTRSLLKAAKVHITRIQYQEIREVISLIDQSRSIRRKREVFESYLKLLQEIKHDDIIGVVNTCSRFLQLPVAVDTDNIKRFFAVATTEGRLKNCQFILQCFQFNQKILTEDSRVHKHMIVLLSIIEKTLCRENSELFFESVYRYMHSPMLSFPNIDIFEIILASIAGCIAVNIFNSHRFKVVLRVVQAAVHTREKDPPNAPDVLSLLIVVAQTIDHAQRFGKKAGFDGCFAEGLCQIAKLPLSLPKITRLMEKVTLIIEKEKITNEQKLFNVMFHLFQLPNNQSASSLESDVLDLHFEEVVKPEIVRNVAEIPLMQKQYSNGIVSLFSLMEVLVERMPETFAKRTSASLYQFIIERVERNPQLSCSIFPVVETITKRRVSEAKLKNEIEEIEELLLRVPHGFIPLIGECLRECYVVGLSDEKQRNIKCLIVHIVECLRQSHLNVEDGCRMVGNILGIPKQLVLTFKEATTSEEMRKGMTKILDVVKTLAPEFIAGSFLPFFFAQDLNAQLKDIIQHDFYMLLKHTSLAAVDLSTALLVYQSLKHEGLLNVFNLSRNPDFKTFFEQWSSGTNQPEIPVPGNLANLVMQHLRRLKVADIQSTTIEICCTILSKHSFGYFGQMPMMGVLDSPSPKEYFDLIISVMKESSHLAEIQHWLAMDSLFAVQCKDVIKATCFWKAGRKSCEAAVYMNTEVSKTLSILCTKGFPNAFPFSGGHLSKELAVMALVINTYEDEDIAVKLFELLCASTECAEACADVVLSWSKEESLLLINKITDWFKERSKMEANLEQLNNEIRIPLQVLSFAAKAFPNSAEDVFNFLSVTTENNGPEDHTSFGRLPVWYKQMTDAGYDPQAIQSWCTSFVLAQDLCSSDIDSLTNLTPEMINLLAAQPESNQITQCLFSSQATQHLQTDKDAFKRRLLLARLLNEFACIAGQLKENLQVARRIQEGVGNLCSTFLDDANATSNLYKIRYNILEDLFVLLFKGESGEHAESLRQLRIERSLSKSLVILFRRLARSVVSRPITFGLIKRVVTTMLRHEVKDPNRLYQENNNAIHLSVLNFESNQDAIHTLQCAGYNQSASMKKDLWYSSSIEMSAFVPTVKSFESSRKESLLRQLWREWKTILKVYEISEVEVNGQKVKQAELFKMSDSLETMETQLQSVQKAIKSKPLMQNNWSYYRQKQLLRGEKRLREKVVAQVKEVTKMIGTQLTKMVLVWENQLLDAVKMCSEKIPDCYAPNGFHSEKPVICGIAVDNRILTLYKEDHGGTRTELENIEIKLYPAGMVVFGAYRSIHPYDTEQMWAAFYKMLLDKRLVPKIFVTNISPAFDWIKQFVAPEVSSPRGINFISCCNLIPSSEDSFDYDPETELLAHHAVLASSQTKELIILTPEKTAELKIDSIRAPFANRKILKKHVDEVILHLKEHGQLKEMHAESRECDQILKRLRTPITKAVEISVDGGEPTQESISKSIDMKRLLPNRSQDTCQYSKDDYSSVILDAVNTVTGDLQGSRTSYDGCQHVVFLQPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZY4</accession>
    <name>A0A6P8HZY4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294666</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558172.1">
        <property type="nucleotide sequence ID" value="XM_031702312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZY4"/>
    <dbReference type="GeneID" id="116294666"/>
    <dbReference type="KEGG" id="aten:116294666"/>
    <dbReference type="InParanoid" id="A0A6P8HZY4"/>
    <dbReference type="OrthoDB" id="5988065at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apextrin C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558172.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15890" checksum="F6EF323AD3E904CD" modified="2020-12-02" version="1">QYCIYGKPYAGKQSYGWIELYDDSPSIFPNVLPFANQRYYHWVIRLYFFCQTSGNKTIPISLPITKPFYLLPYGSRDCQQVKWMVATTEWIKYYTPYYDYRYHKTHGTVPHHKVDDRNHNNGITMFYCYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2F9</accession>
    <name>A0A6P8I2F9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559082.1">
        <property type="nucleotide sequence ID" value="XM_031703222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2F9"/>
    <dbReference type="GeneID" id="116295426"/>
    <dbReference type="KEGG" id="aten:116295426"/>
    <dbReference type="InParanoid" id="A0A6P8I2F9"/>
    <dbReference type="OrthoDB" id="9747447at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF193">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559082.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="15826" checksum="687502E7267DE65E" modified="2020-12-02" version="1">FFRKSIPRISTYLQSAFSFKSSLTNAHSSRGASTNVGTPSQAQVVIAGGGVIGCSVAYHLAKLGWKDILLLEQGSVSGGTTWHAVGLLGKLRGTRLETYICDYAETLYKRLEEETGLQSGFKKCGGLLIARSDDRLTAVKRTAVQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I333</accession>
    <name>A0A6P8I333_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116298043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562243.1">
        <property type="nucleotide sequence ID" value="XM_031706383.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I333">
        <property type="interactions" value="2924"/>
    </dbReference>
    <dbReference type="GeneID" id="116298043"/>
    <dbReference type="KEGG" id="aten:116298043"/>
    <dbReference type="InParanoid" id="A0A6P8I333"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="11">
        <location>
            <begin position="25"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="527"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1538"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1549"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031562243.1"/>
        </source>
    </evidence>
    <sequence length="1585" mass="178523" checksum="9CF666CD3A5A2831" modified="2020-12-02" version="1">MDIPISSRGLWHILTGRSSLQEPEQIEEELNENRQKLLEGILWYKVPSASSLEKLQKAVQIKPKRKELVKNLSKILNLDEWQALELFGSYLENEFRGSNQQLQLICKNETQTENLITKIQEYYFEERLHSLQCLKYLLSYWQDPQHAFREEFAECIEKLQENDILINKVIEQYKMCSTSQVSVSQTYNNLLERNRNCRLALQYLREQVLLLEIIFLYYKEYLHPSKSLLQMAKLFQSQGFGTKQXNRHLLDARAEPLIAQISYLQVLILIESLNLEGVRNFMDTGNFKQHHLVQEPGGVELLDRYFVSWGDLPQHGPVMLAWAVFRYVTMETDQEQDVRRIGSKALQCHVFEFFDGLLKSEAFSGIMPVANTCKSVVYGLLFVVLTMFQEDTLGDTKLLVSVLSQTLTERGLCIDFWDTSIDTGAGLLLKSACNNFPLQFSPLLELLKSLAGEENSAAKVFEYLDNMPSYTELLRENKVGDVDCTGDDQVWKIVKPKVLYRGGLREDNIIAIVDLTNEILKNNWSIAEQLEPIISRLYFIVQRCAPSPNLPQNLLASCLSCLATVASHHPLQVWFSLQQTGFLPHCTSAHSIDENKSTIESMNIASGNLGVILSTREQPLGQYPITMATLRLFLQLMCGIGQAQEETDQPVNFLDLAACLVFVLRETFTGFYKWKFTAAKDREEIGQRSLEIFNAVLGLQLKNPQQKKDEGMDLDISEARQQIRSALVLQDVLAFSLLNTAAGQSLLYILGTGVDTVDRLISVGGATGSHALAVVQLIKLAFSVLNKLLATKHKDEEISPLEQALSTQVIHQFKDSSSVYSASSSQSHLVTVIASYIHHRADCRLPTLATLLLKRLCMVAPMSMYASFGSDAVALRDVFVSRLRSLTEDVKLKIAILEFIATAVETQPGLIELFLDLKEKDKNSQEFTLGDRSCLHAVLSMVDPTKQVGGLVISPHLQTCSYAFQILALETYYVSSGQLDSSMKTSLKTFASRQRYQYWSSLLRSDRFQEEQSIPSSRSVSPLFFKSSENEYLRLLRSWRSFLVMASTIEQTDIYGLRDPKTRNEILKDTLEALQIKVSRPVTLDVLAAAHELSSLYLMLFNKWKSSVKTVSSTFNTLVEILESANNNDGQLLDHIRIPVFSSISIGTLDRGYAMALLPLACEPLEYLNGRLGKEDKQHDKVLELSVFIIDEILNILLSNPGQWLPVLREHALFASLVQALDICVKTREKLEFSEAVLHLFLSLSRIPVSAEALALNNLSQTLCLGVASLFNTVEAENKSEGSHQRLTTSIQVGESNVSISSRNDWNKVWHLSLSVMASMLRTLRHGFLKEALDFAGVHRERLARAMDMIRGSQSTEALQEAEDVTVFLFELGHFAKEWRFGLLDVLELLLARVGVLCQTCIALLTHPRLLAHLLEGMDIEDNLPIATLGFSSPAIDREEPLSFGTLLACLNMCLTNLSPGDVRSPVKSPVKTLSETLPKFLLMFAMENALVLALSQASRYLRDPSVDPRVKQLLKRELGSELGHFLGGLNRHFVRRGLPPSPLSDRASPSTSSKKTPTKHPAFSEVPEQKLFKLADLYVKKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3C2</accession>
    <name>A0A6P8I3C2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentraxin-related protein PTX3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559397.1">
        <property type="nucleotide sequence ID" value="XM_031703537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3C2"/>
    <dbReference type="GeneID" id="116295649"/>
    <dbReference type="KEGG" id="aten:116295649"/>
    <dbReference type="InParanoid" id="A0A6P8I3C2"/>
    <dbReference type="OrthoDB" id="5945403at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051005">
        <property type="entry name" value="Pentraxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45869">
        <property type="entry name" value="C-REACTIVE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45869:SF8">
        <property type="entry name" value="LAMG-LIKE JELLYROLL FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pentraxin (PTX)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559397.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23627" checksum="CBFDD07669DCD381" modified="2020-12-02" version="1">SYDLKFKDNEYWPDSAIGGFPALPEFSICIWFNLDGAKPKQRNLGPMKILDYVNSADIIKSFPIFYIESSINEGDTQGYISFMSERRGASLYFDKGNKWHHFCLTRNSITGETTLFLDGENKLTDVYSEGLTPSSEGRMRIGGFARTNFEGKISGLNIWNRVLSDEEVHKMAQSCDDSSGSFKDWYDIKSELTMKKYILHEPSRCMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7Y1</accession>
    <name>A0A6P8I7Y1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CD59 glycoprotein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116298925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563366.1">
        <property type="nucleotide sequence ID" value="XM_031707506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7Y1"/>
    <dbReference type="FunCoup" id="A0A6P8I7Y1">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="GeneID" id="116298925"/>
    <dbReference type="KEGG" id="aten:116298925"/>
    <dbReference type="InParanoid" id="A0A6P8I7Y1"/>
    <dbReference type="OrthoDB" id="5953909at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23553">
        <property type="entry name" value="TFP_LU_ECD_Ly6PGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF3">
        <property type="entry name" value="PROTEIN SLEEPLESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027909749" evidence="3">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="4">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563366.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12423" checksum="918379935971D1DE" modified="2020-12-02" version="1">MKLLIVTLCVLALLIPSALSLKCYVCNKKNENCKTGETTCKSSQDRCGKSILNGVINKSCTTSQVCSKAKEFCKNQEKCEAYCCDSDLCNGGVPLKPVTFVTLLAMALAVAKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8P5</accession>
    <name>A0A6P8I8P5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gelsolin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564934.1">
        <property type="nucleotide sequence ID" value="XM_031709074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8P5"/>
    <dbReference type="FunCoup" id="A0A6P8I8P5">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="GeneID" id="116300249"/>
    <dbReference type="KEGG" id="aten:116300249"/>
    <dbReference type="InParanoid" id="A0A6P8I8P5"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000043">
        <property type="entry name" value="macrophage-capping protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="177"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="301"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564934.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41857" checksum="8579EF95F5E22AAF" modified="2020-12-02" version="1">MRKAKQYDWKDSNLALFGSDTEKNVKKESAQTEKAWKGAGSKLGLQIWRIKKFKVTDVPKEEYGSFYNGDSYILLNTYKKDPDSMAFDYDVHFWIGKFSTQDEYGTAAYKTVELDTLLDDKPIQHREVEGHESALFKSYFKSLTYWKGGADSGFRCVEPTSYEPRLLHVHGTKKKIECKEIPFCMDNLTKDDVFVIDLGLKIFQWNGDDANKDERYSAGQYIRVLKSERSGKPEVIVLDDQTLDDVPEELLEVIPKSSNEDPDEDLEDPDPKEKVLFQLSDRTGSLQFNEIARGTAVKRNLLKNDDVFILDTGSHCYVWTGPQASIDERRNAMTYAHNYLSSTKHPLLPVTCIKGGAESNEFNKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8S7</accession>
    <name>A0A6P8I8S7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nicotinamide N-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116299157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563646.1">
        <property type="nucleotide sequence ID" value="XM_031707786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8S7"/>
    <dbReference type="FunCoup" id="A0A6P8I8S7">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="GeneID" id="116299157"/>
    <dbReference type="KEGG" id="aten:116299157"/>
    <dbReference type="InParanoid" id="A0A6P8I8S7"/>
    <dbReference type="OrthoDB" id="5945614at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053384">
        <property type="entry name" value="SAM-dep_methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041360">
        <property type="entry name" value="GntF_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867:SF17">
        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563646.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29340" checksum="62213FCDC4CC534F" modified="2020-12-02" version="1">MTTKDYERFFDPYDYMDTYYDDPKKDRFSLGRIEQFWSKIGGYNLKVLEYGGGPIISRLVTAAPHAREIIFADYCKANRQAVQAWIDKDSKAFDWRDTFDFIVGELEGKGTDEVAKREDELRQKIRAIVPCDIKSDNILEIPASLGDKYGPPYDVVATSLCLEAVVESEQEYKDTVAKLAKLVKPGGYLMMYAVISQTFYMVGSKKFSSFCLTKEMVEESMKDTGAKIMHIDMATSSGIKLDYMADTQDEMFIYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8W8</accession>
    <name>A0A6P8I8W8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116299193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563681.1">
        <property type="nucleotide sequence ID" value="XM_031707821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299193"/>
    <dbReference type="KEGG" id="aten:116299193"/>
    <dbReference type="InParanoid" id="A0A6P8I8W8"/>
    <dbReference type="OrthoDB" id="10286726at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00045">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="3">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563681.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="68133" checksum="FACD0003E1455253" modified="2020-12-02" version="1">MALNSTKTCNNAINPFHKFSTKIALELLTRDVKVLKHLTLDKVPGGVLESIKAEEEYSGLNWFLCLTKHXVICEYNVKFLIEALEAANRHDLAKKAKEYQDQIVGEREELDRTETRLISKSIFYTTRDCVHLFFAVEMGYAAGXTHMCKGMINASQKALNTCCKEPLLSHNIELALIKFGNHHTKRNTNSSAPRGQESDVAXLVKEMSKNLSMCXCPXXYSXCGGRGGTSGIADALAKFVDYVQRNEMQRQIPKICILICFISKECSDLEYFRCPEGKDAIKLCNTLAECAIPLYIIGIDHAGVQACARGTXHVTEENPFLSGITFIGGGQYFQVSDMNHVEQAINCIIKENXSIEEHMGTVDDIVIIERNKEGGNLNVEHLAEHLRENLNLRSCTVDNIKLNNESPQAISQIVQRVAWADDLNDAINAVKSWREQNESLDRTRSIDFSLSRGSRSFSNYSAVSQYSCESFSSLPTSEMQAQNQQTLFPELKPNSASSMSRSIFSSGHTSTSGGESASFQSLFSSTTTQNLQTHQPMEPSLKPSTRRRKRKAEHTTTTQNKXRNDSESTKNNSSFLTLAERQRVGMDVARRMVRRQITRQAYYQRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8Y7</accession>
    <name>A0A6P8I8Y7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116299945 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116299945</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564532.1">
        <property type="nucleotide sequence ID" value="XM_031708672.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564533.1">
        <property type="nucleotide sequence ID" value="XM_031708673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8Y7"/>
    <dbReference type="GeneID" id="116299945"/>
    <dbReference type="KEGG" id="aten:116299945"/>
    <dbReference type="OrthoDB" id="5975376at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564533.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="39937" checksum="015D4D0394A867C6" modified="2020-12-02" version="1">MLSYARDSVYIYQSRTKRSGKFQQGPPGRPGKNGKDGVNGTMGPKGGQGPQGPQGTQGPQGPPGPPGPMAKVDNSTLNKSCNETKDYGQIKYSNYNVQVCTPTGWKSLALKEDICDNSSVPRIDLETFKISKFGALFQFNDNLRVNLSPGSVATSVNLTAAFEDHASNNTVPEYLPSAMSKAIRLKGRKHINLIGIPVDFWSGNEWSVMALIKFTDQGLNSQKEIPVIGAGGQQNGKGFHLGIRSKRVLHGFYSNDMIGDAILNFDQWYQITWTWKKASPTGTRQIFVNGVLDKKQDGTSGFNGKSDNTEIGAWWNDTSNRNNNIQIDTLYIIDKVVDYKSKWTSTDWLELCQARLVNNDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9A0</accession>
    <name>A0A6P8I9A0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metalloproteinase inhibitor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561687.1">
        <property type="nucleotide sequence ID" value="XM_031705827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9A0"/>
    <dbReference type="FunCoup" id="A0A6P8I9A0">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="GeneID" id="116297573"/>
    <dbReference type="KEGG" id="aten:116297573"/>
    <dbReference type="InParanoid" id="A0A6P8I9A0"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="9" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="9" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028148640" evidence="6">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="36"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561687.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25780" checksum="01E70259BAAE585B" modified="2020-12-02" version="1">MKSISVLVIFCLLINEGFSLSCRCVPGNDHPQDKFCTSDYVLRGLVESGPVTKTIQIPRPDNPENSWTRSVLVYRVQIQRIFKGENKVKNTTPLKDYPGKVPLPMEVAIYTDNNSCAAQLEQGRDYVLGGYIDGQDLEIFSCNWIQTWGSLSSGQRIGIRRYYGRNCACRTSLCSWMDPLGGMMDYYCGLNNLYCAMRKDHATCSWKDIGRGYRECIRDATILGFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA26</accession>
    <name>A0A6P8IA26_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gelsolin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564933.1">
        <property type="nucleotide sequence ID" value="XM_031709073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IA26"/>
    <dbReference type="FunCoup" id="A0A6P8IA26">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="GeneID" id="116300248"/>
    <dbReference type="KEGG" id="aten:116300248"/>
    <dbReference type="InParanoid" id="A0A6P8IA26"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000043">
        <property type="entry name" value="macrophage-capping protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF137">
        <property type="entry name" value="VILLIN-LIKE PROTEIN QUAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="291"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564933.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42032" checksum="E234F067CA1C58FF" modified="2020-12-02" version="1">MAKGLVKAKEYDWKDSNLALFGSDIEKNVKREAAGTELAWQSAGKRCGLQIWRIEQFKVKALQRNDYGKFYNGDSYIILNTYQKEESDEFFYDVHFWIGSNSSQDEYGTAAYKTVELDIYLGDKPVQHREVMGHESKLFKSYFPTLRVLEGGVKSGFKHVLPQNYESRLLRVRGTTIRNCKVEQVPFTKHSLDSNDVFILDKGTTLYQWNGRGCDKDEKFKATQVTQEIKSERNGRVKIEVFDEDEISSEHVFYKFFPNKTVEQHTGDYDSFGKALFRLSDKHGSLSLSQVSKGRISMSNFNSNDVFLFDTGHDLFVWIGAKASVDERRKALEYGHNYLIQTDHPCAAITCISEGDHNEDFAEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAE4</accession>
    <name>A0A6P8IAE4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ciliary-associated calcium-binding coiled-coil protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564151.1">
        <property type="nucleotide sequence ID" value="XM_031708291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAE4"/>
    <dbReference type="FunCoup" id="A0A6P8IAE4">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="GeneID" id="116299616"/>
    <dbReference type="KEGG" id="aten:116299616"/>
    <dbReference type="InParanoid" id="A0A6P8IAE4"/>
    <dbReference type="OrthoDB" id="2126027at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF3">
        <property type="entry name" value="CILIARY-ASSOCIATED CALCIUM-BINDING COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564151.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="35873" checksum="72CE1697B1022A60" modified="2020-12-02" version="1">MRKSEFPRVVKTKVMVRKKLTKKIEKDDVEKQMEDDVLQKEEVKESLAYKVISEDQTNALKELTPRELEAKLAEILNLTNYHISLPEACVLDYYVAGFWFTKEENFNNQQTSAFFTLLKILVENIKDKHMSLAESLVEFKRLLVGIGMENCPKSGGLECFDISQAKVITNYFTDSLFQHFKLYEFLFTQEPSEEVITTEVKVEVPPMADIPFPPPLDEGMTEDLWREYIMTPPTTPEPETNDEAGENEEVSKEKGKTDEIAKDILTTIKPEHIKTIIRKTADGIFENFKIEVETKLKERENNYAAKITKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAX8</accession>
    <name>A0A6P8IAX8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">BRCA1-associated RING domain protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299812</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564381.1">
        <property type="nucleotide sequence ID" value="XM_031708521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAX8"/>
    <dbReference type="FunCoup" id="A0A6P8IAX8">
        <property type="interactions" value="786"/>
    </dbReference>
    <dbReference type="GeneID" id="116299812"/>
    <dbReference type="KEGG" id="aten:116299812"/>
    <dbReference type="InParanoid" id="A0A6P8IAX8"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17734">
        <property type="entry name" value="BRCT_Bard1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17720">
        <property type="entry name" value="BRCT_Bard1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000006">
        <property type="entry name" value="Breast cancer type 1 susceptibility protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039503">
        <property type="entry name" value="BARD1_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14835">
        <property type="entry name" value="zf-RING_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="514"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="630"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031564381.1"/>
        </source>
    </evidence>
    <sequence length="761" mass="84456" checksum="6586580AD6D44F41" modified="2020-12-02" version="1">MIKWNKTKLALSNLERLLTCTICKRLVQDPCTLEACDHHFCRNCVEELVGIDSKCPECGAFAWSKDLKVNRRLADILSLCKLIRTTVGNNDDVAETPPKQEACGVNVMLGTASRNLEKTDKIAKDNDIVTSIDGDKTLLKHNWQPVVRSEEGNNNTNNSSVCEREEYDVHLESSCSSQEYENEDINSSIELFSTNDSFCSEQDVNQPGTKSKYSTKTCGKESDIVTCTKYDKDRGASFVNHQNILKSKTNAYIRSDVGDLQVKGKKRKMSESELGIGNRESNLSLQKQVSIVENGTPETEKSIMSQSDVKGDSSSNKKRSRLALTHKNVSTSPSAKANISTPQSKIRKKLNTSPASVKSILELSPAHLTKRNKRGEGLLHIAAIKGYYEDAKYLLEKGADPNARDNAGWSPLHESCNHGHVTIAELLLDNGAIVNLPGGPEHETPLHDAVANGQLEVARVLVRRGASLHARNNQGLTPIEYAFTDPMKRLLEQESSVQCQTLTNDKENILLQTNLPPAHQSAKVLLYTGLSTEQKEKLELCASILGGKLVNEFSIDVTHIITSTSNSGLCRRTIKYLSGILCGKWIVSFGWITKCLSTNKWVDEAPYEVKGTSTAKSGVPHQARVNHLQQLPGLFDGCQFFFSGTFDPKTPSKEDLISLVKYGGGKILTREPKQEIDYSPFIIQSKYNKDTMHLSTLSTVAYHAQPDSTQYRCTIYIIYDPLSQNKQAVRNVRGPSIAPVGWLLDCISKFEIIDIEKFLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB66</accession>
    <name>A0A6P8IB66_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box/LRR-repeat protein 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562607.1">
        <property type="nucleotide sequence ID" value="XM_031706747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IB66"/>
    <dbReference type="GeneID" id="116298340"/>
    <dbReference type="KEGG" id="aten:116298340"/>
    <dbReference type="InParanoid" id="A0A6P8IB66"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562607.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32486" checksum="228DAA42BCB50D95" modified="2020-12-02" version="1">MAAKRMTRRNDEHTRKQSHQDYIDYLKSIILKFTEERDLEKDYAKKVVKIDPFITLPPEIVFRILRFLHLNEICISRRVSKAWKRTIENYFQHIRVLDCVPFESVLTAEGLKGILTCLKNLRELHAETCWFSFTEESFSLLKNCPKLRSLSSSKCKGLTDKTLKLLAAHCKELEELDLSSCFQISDEGLVPLTENCPKLKEVCVSSCYGITDTSVEALAVNCPFLQDLDISWCYKVTDQSLSLFLNPEKKIKSLRIKDCSRVTQEMITHLVEKGISVNCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB80</accession>
    <name>A0A6P8IB80_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein 10-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">GTP-binding protein 10-like isoform X2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">GTP-binding protein 10-like isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC116298367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7 8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562647.1">
        <property type="nucleotide sequence ID" value="XM_031706787.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562649.1">
        <property type="nucleotide sequence ID" value="XM_031706789.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562650.1">
        <property type="nucleotide sequence ID" value="XM_031706790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IB80"/>
    <dbReference type="GeneID" id="116298367"/>
    <dbReference type="KEGG" id="aten:116298367"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF43">
        <property type="entry name" value="GTP-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="4">
        <location>
            <begin position="297"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="435"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031562647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562650.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="72210" checksum="267EF6EA04FA12C8" modified="2020-12-02" version="1">MAAGSSVKFTRNFLRCSSSLTRIQRNLKRFRRITTVSGDELVNSGQEKVPSVVNAEKPKPKQTLSNINSKTSLYPSYKELKELEQKPLKVLPFNVAFGGKFVIWLLQKYQAEKVLILVRVKVLARELCLELKENGFSCTEVSSQADKDYVNERLSEDGIVVASYQDTSIWESHSQADLVIMVQPPLESLPVTSMFLRHLNIESSKGMAVMLYNQNDLEFIKQIQKYVDVIKINPPSFYSVQHSNSTNVQLDPSSVTVPALPKSEPLSDLEKPIPAKIPQYALYRPAVPVPRSVSERTRLNDRARLYVRGGSGGQGSPTYAGLGGDGGHVILQCQEGASLQHFVLKENRRLIASHGEHFAKEKRKKKGRRGLDLVVPVPPGITVSTDDGHVVGQLNSVGSRLVVAQGGEGGNPSREGWCGEKGTPLMINLDLKLIADVGLIGFPNAGKSTLLGELSRATVKTGDFPFTTIRPSIGMLEFPDLFQVSIADLPGLVEGAHYNRGMGHKFLKHVERTKVLALVVDINGFQLSEKHPQRTAFQSLCLLVKELYSYDNSLAYRPKILLLSKMDTDDADIKYNEFMDELKSLNERGLFNVLQEIPPDVHLQEIAKKQKPRDLTTDSIKFEQVIPLSSISGQGLEEVRQRLRDMIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHZ3</accession>
    <name>A0A6P8IHZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine incorporator 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116301491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566422.1">
        <property type="nucleotide sequence ID" value="XM_031710562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHZ3"/>
    <dbReference type="GeneID" id="116301491"/>
    <dbReference type="KEGG" id="aten:116301491"/>
    <dbReference type="InParanoid" id="A0A6P8IHZ3"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031566422.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48998" checksum="0D4F4416B2B8174C" modified="2020-12-02" version="1">MDFQLCSVYTSVAKPAAGKVIYLGFLFIGTLLSLLAFFPGVRSFFVRHSQFCDRNLNFEKCDVLVGHVLLYRVYIGMIIFFFLISVINCQMSIFSSSASVIENGLWFLKWNLFCFFVLISLLIPEGRICHTLMHIGWIAAIIVIFMELILLIDFAKYLNSYWIEKIETSLNSKLWHFLLILITSLLYTLFIAFTIYFYVIYSTTKGCHSHSVFIAVIVFLCLGASLLSFHPKVREAGLLQAGMVATYTMYLTWSALSHSSDKKCNPTYLTSNWNDTKDDYLFSLKPIMIIDITILFGILFYGIYRVKNLNEFLNNLHLINCCSQSDEDDTDEPIESNEQAILSSSYLSYYICILLAILYILMVVSNYYTPEGILGTNKVLLETKDGMMDVNEYTKEFSMLTAMSIKMTMSFVFVLMFMWTAVASLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHZ9</accession>
    <name>A0A6P8IHZ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566486.1">
        <property type="nucleotide sequence ID" value="XM_031710626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHZ9"/>
    <dbReference type="GeneID" id="116301519"/>
    <dbReference type="KEGG" id="aten:116301519"/>
    <dbReference type="InParanoid" id="A0A6P8IHZ9"/>
    <dbReference type="OrthoDB" id="10287653at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566486.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46096" checksum="9BC21BF0793B5E58" modified="2020-12-02" version="1">MSILDVNFEAIGESSRVSSAPSTPRVDNVEHFILADFENYCNPTERNTEEKPQLVNTNSDETTDILTPEELSENLDGGLNVNQQLWLDNSRHTKNEALDNALNLSPSLYSNNNQVPIQMDSEGQHYLTIKDSNSAAMESPTKISWSNIPIHPERSSEYMVRGGNHFPSLHGTVNTSVLEKARPISSTWSDPNDHEVANYLAEVVTVPQVYSQAQPNHLRVELGNDGQQYMIVDGKYFSENAQDMGAFQLGSNNQYYLTGTQLMAEYPTISHSAATQSTSTASASACTLNVINQMGIFQNYNENETEVIDKDVLEEQKRKEQMQIRRREKNKDCSRAFRRNQKEKERKLREGRIEKQARLKELNKKNDNFIRMLSKAALQGCEKAKGIAATSMETWNKENNSFGGLSANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IID2</accession>
    <name>A0A6P8IID2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC116301615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116301615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566562.1">
        <property type="nucleotide sequence ID" value="XM_031710702.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IID2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="116301615"/>
    <dbReference type="KEGG" id="aten:116301615"/>
    <dbReference type="InParanoid" id="A0A6P8IID2"/>
    <dbReference type="OrthoDB" id="5963630at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027626030" evidence="10">
        <location>
            <begin position="22"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="83"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="395"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="674"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="754"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="12">
        <location>
            <begin position="1359"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="1422"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566562.1"/>
        </source>
    </evidence>
    <sequence length="1655" mass="174168" checksum="0E2F66553FEB6FC0" modified="2020-12-02" version="1">MKAFVLACVLGVSLLATFAHGCSDNNRGCPTWAKRGYCKSGSYVTWMSRNCQKSCGICGGGGSGGSGGSGGSGQCGFKPNVRIVGGTEAPKGAWPWQAQIRTTSGFSFCGGTLVHPQWVVTAAHCTAGKSASSIRVRLGAHYRTGNVGTEQDFQVARIVNHHSYKRPYGMAHDISLLKLHKPARVNKAVGLACLPSSSGSVANGKQCWVTGFGRLSSGGSSPRVLMQVSVPVVSQSTCKRAYGSSIHDSMVCAGFARGGKDSCQGDSGGPLVCEAGGKYYLEGVVSWGHGCAAPGKYGVYARVRYLRQWVDSTMSRCCDDIDVRCPGYARRQFCKIGGLVQYMKTNCKKSCGLCEDGGGPGGSGGSGGSGGSGGSGGSGGTVAPGQCGFKPNARIVGGTAAPKGAWPWHTMLRSRYGSARCGGTLVHPQWVVTAAHCVKDEYFPMHFLVRLGAHLRKGEVGTEQDFKIAKVIRHNNYQKPYGKANDIALIKLDRPAQINRAVGLACLPPSSGSVEDGKNCWVTGFGRLFSHGLAAPKVLMQVSVPVVNQAKCINAYGAELIHGSMICAGLDQGGKDSCQGDSGGPLVCEAGGKYYLEGVVSWGHGCAAPGKYGVYTRVRHKVCLLHLNRPKLATVLLYKRKKECSYFTLFFTMRSSLLLCAFAVSIFASFAQGCVDNDNRCASYAQRNFCKFGSLVPWMKKNCKRSCNICEGGSTGGGSGGSGGSGGSGGSGGSGGSGGTVVPGQCGFKPSARIVGGTEAPQGAWSWHAMLRIAFNGLPFCGGTLVHPNWVITAAHCVRSRGPKDVIVRLGAHRRRGTVGTEQDIKVTKVLLHESYRKPYGIAHDIALLKLERPAQINRAVGLACLPSSSGSVADGKHCWVSGFGRLSQNGNRPTVLMQVSVPIVNQAKCTQAYGSKLIHESMICAGLDQGGKDACQGDSGGPMVCEAGGKYYLEGVVSWGKGCAVAKQYGVYARVRYLRQWVNQKISSNYRVSIACTMKFSVLLCFLGVAVLASFAHGCTDLDSRCPARASRHFCKYGSLVTWMKKNCQKSCGLCDGIGGGSGGSGGSGGSGGSGGSGGSGGTVAPGQCGIKPSARIVGGTEAPKGAWPWHAMLRTLSNFPFCGGTLIHPQWVVTAAHCVAKKSASSIRVRLGAHRRRGDVGTEQDFQITRKISHESYRKPYGIAHDIALLKLHKPAQINKAVGLACLPSSSGSVADGKHCWVSGFGRLYQNGASPTVLMQVSVPIVNQAKCTKAYGSNLIHDSMICAGLDQGGKDACQGDSGGPMVCEAGGKYYLEGVVSWGKGCAVAKQYGVYARVRYLKQWVDKIISSNIIMCWVSSLKTFELWGENIQCSGQGCSDNNRHCSYWAGRGYCTGQFESYMKLNCKKTCKLCGGGGGGGDGGTGGSGGSGQCGFKPNVRIVGGAEAPKGAWPWQAQVRTTSGFTFCGGTLVHPQWVVTAAHCTVRKSASSIRIRLGAHYRSGATGTEQDFQVERIVNHHSYKRPYGMAHDISLLKLHKPARVNKAVGLACLPSSSGSVANGKQCWVTGFGTLSSGGSLSKVLMQVSVPIVSQSTCKRAYSSIHDSMVCAGLARGGKDSCQGDSGGPMVCEMGGKYYLEGVVSWGQGCASPGKYGVYARVRYLRQWVDSTMSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8III9</accession>
    <name>A0A6P8III9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase TRIM71-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566617.1">
        <property type="nucleotide sequence ID" value="XM_031710757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301665"/>
    <dbReference type="KEGG" id="aten:116301665"/>
    <dbReference type="InParanoid" id="A0A6P8III9"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF51">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="446"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566617.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54867" checksum="4357E85498CE891D" modified="2020-12-02" version="1">MPARNVHAWYKLAFKLLVSDQWHVISEKVENGDLCYRWVKEQLMAALHDVEKNAWQKPLGNAAFTFREQLVGMRSPSLSEETYLKAQHWLGLQNGMTALRDESTPVRHRLGGAKLALLEGTFVHFDKPEGAGSAICDVFTNLCQIDPVVEAIYENKDAQLAAEVKIMFDSSKEYAESMKLPIDDLVELEFDPSCLPTDPPSLFKPPEIWAFGDIGNEDGFLSDPDKIQIDKEGNFLVMDQDLTXVNVETVQRIQLFNPLGKFIKVILKRGEGKVNGMKDFCLNKDGNLVVVDTDDNDKTRLQVFDYDGNQMMVIDVDKDNPDSVAAIRFVYVDDDGNMICGDIGDSCIRIYGPDGTLKSKFGQWGMGEGQFLNIGSVTAQGGKIYVFDNGVDKIETVVFDYDGKFLSKFDSGIKHWQLVFDERNQHFYAVQDDHTIEILALNGTSKGKTGSFGYDLKDFWFPSSVAILEDGRIAVADRSNNRIKVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIX4</accession>
    <name>A0A6P8IIX4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116301528</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031566463.1">
        <property type="nucleotide sequence ID" value="XM_031710603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301528"/>
    <dbReference type="KEGG" id="aten:116301528"/>
    <dbReference type="InParanoid" id="A0A6P8IIX4"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="17">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="16">
        <location>
            <begin position="134"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031566463.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="49103" checksum="86AD419F1C4DE598" modified="2020-12-02" version="1">MLRAPFRIAAVSHCKDLLSIAWQDGKQSNFPNIWLRSAARDPEVFDAGSLLYKRDDYVEFICKESPLVRAEHEKGSEDVLVEWGDHLGTFNASWLRAQDHNINKDLCKKPDITLWDANFKFPVYNYSESMENFDSWFGDLRKYGLAIFQGVPQNEAGIIDLIHSIGQEAQRTHPTNILRILQDSKKESSYDTSTYTSNXHPMHVDTPYYASMHRLTCLLGTRYIAPVKDTNNFLVDNLKVVEEIRREEPEAYDLLRTIPVRLARRRLTVPEVVKPKEFYFYHLDNVEYKPIIAYDKREKHDYINLTNKHAGVDLSVFKDHATMKKHYDAYRLLQKKLDEKANQKRVIIKEGVAVLMNNGRISHGREPIHSSSQRSLLLAFLSEGMWNSRWRIMNGQKSGLEEKWLYGCSPEQLEILADRKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIZ2</accession>
    <name>A0A6P8IIZ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Syndecan-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116301542</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syndecan proteoglycan family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566478.1">
        <property type="nucleotide sequence ID" value="XM_031710618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIZ2"/>
    <dbReference type="GeneID" id="116301542"/>
    <dbReference type="KEGG" id="aten:116301542"/>
    <dbReference type="InParanoid" id="A0A6P8IIZ2"/>
    <dbReference type="OrthoDB" id="6022752at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001050">
        <property type="entry name" value="Syndecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915:SF1">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01034">
        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027598272" evidence="11">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Syndecan/Neurexin" evidence="12">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566478.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="24689" checksum="5AA8BD1BD40C91C3" modified="2020-12-02" version="1">MRLFIVILTAFLCGLVAAADSNSKDGTMFIDSNIDVTTIKPNQKISSKDSESSGDDDDGSGDVQGDSSGSGSGVVVTPITTASQKTVRPTTREENVVPKVTVKKIPSTKPTTEPEAVTSSKKPDILTEEVGKITTTTGDAVSKTVRPTTEEDMYGGGVGNDGNVAARKQEKAGLRVLTKEVIAAVIVGGICAIILIAFLVYRLRKRDEGSYVLTDSAYKDTNKLRGDPGKEAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJM5</accession>
    <name>A0A6P8IJM5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116301698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566653.1">
        <property type="nucleotide sequence ID" value="XM_031710793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJM5"/>
    <dbReference type="FunCoup" id="A0A6P8IJM5">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="GeneID" id="116301698"/>
    <dbReference type="KEGG" id="aten:116301698"/>
    <dbReference type="InParanoid" id="A0A6P8IJM5"/>
    <dbReference type="OrthoDB" id="5960162at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20913">
        <property type="entry name" value="DCAF15-CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20917">
        <property type="entry name" value="DCAF15-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038914">
        <property type="entry name" value="DCAF15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047319">
        <property type="entry name" value="DCAF15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032734">
        <property type="entry name" value="DCAF15_WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28541:SF1">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14939">
        <property type="entry name" value="DCAF15_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 15 WD40 repeat-containing" evidence="2">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566653.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="65768" checksum="493531E0C3B88702" modified="2020-12-02" version="1">MKTAAKNQVQKLALRQVCGSLQPFSRSNPVRLFTKYSQKCCFKLSDILDKKGEIRDGHVILGFTKDGTHLISYSLVIDTRLELPQPVYTYTLHWWRFQYSKPLFKVQSATLFYDQPISHALHLIVSQSPDEKQVIVWGRGPTSKEEQTCRCYVTVCAAPPNKPCDKCKAYSNKPCHEHSYSAHIMYDSLPPYPVFLPSICLQIPGTVFFNSGDSLIAFKCVPCVNDFEVENAIHEFKNSHQLPGDLSGHGPSEVEEIPTIQKQMVSDDNNDTDCINLREGNKEDVDYGNGDEPCKTKKDSICELESLTTGLIIEQHDKNRNRTPPLVPSVSPRSSLMPSPNTSPMSSFGTILSTTESRLSCDSLTTYSYRKFTTPCDVQDNSFDTSDETVEVPALVMHGTQELESVIYSEHKGPNSSSGPSILVCQALLDMEQCISELIASNEDLYHRYKSLRDYDCQFLGVCEDTGDVIVMVKILMFAKPTRSSLSDGLQVSPSPLLQQTGFVFSWNVWNGTLQTLYCLETQDHPQGKSLSRSESTVEYARSLRQGTTVPVGFSSQVRVFSNYTVFTEKSLKYLLHPFLPIIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKZ3</accession>
    <name>A0A6P8IKZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116302242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567335.1">
        <property type="nucleotide sequence ID" value="XM_031711475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKZ3"/>
    <dbReference type="GeneID" id="116302242"/>
    <dbReference type="KEGG" id="aten:116302242"/>
    <dbReference type="InParanoid" id="A0A6P8IKZ3"/>
    <dbReference type="OrthoDB" id="9975373at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469:SF0">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567335.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13288" checksum="B9E94938E44912E8" modified="2020-12-02" version="1">MVIGDSRNRLEELESNLNGGPWDLRSKKKFFFKAYTGLFSVEVNFGLLRCPNTSGRKVQRSMYKDLIRLLVPDPTSTYLTNQHLKTKGELEFLGDKLLEGGQLGEMKNGINYREDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM62</accession>
    <name>A0A6P8IM62_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myb-like protein V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567882.1">
        <property type="nucleotide sequence ID" value="XM_031712022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM62"/>
    <dbReference type="FunCoup" id="A0A6P8IM62">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="GeneID" id="116302678"/>
    <dbReference type="KEGG" id="aten:116302678"/>
    <dbReference type="InParanoid" id="A0A6P8IM62"/>
    <dbReference type="OrthoDB" id="9901850at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039062">
        <property type="entry name" value="SPAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031478">
        <property type="entry name" value="SPATA1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14421">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14421:SF3">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15743">
        <property type="entry name" value="SPATA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 1 C-terminal" evidence="3">
        <location>
            <begin position="617"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="715"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567882.1"/>
        </source>
    </evidence>
    <sequence length="792" mass="90330" checksum="3DA255FCB8CA9D40" modified="2020-12-02" version="1">MSDLSSGRSVRNQLADLHIFVVPEQLWLDKYRTAFNNIALESVSAGFVRVHPETNLHQLRESIEEQLGEDIIPEEFIFLRSVGRCMAVVKENQEHLLRAADFLPPIAYSPEIFLLPGLHEHYAKPGTDSKNVVIATQGHTTAGMSTTHPFQLPMIPPQYATNQHLTAQPSYPTQKRYHGNQEENKRYEDDYQRTQKNDQTRYDDDDDNDDDDGDQNIVDNQDQENKTKYQRESFDEEQVHGQFESQGGRHSDGYHGDSEHRSSGENQDLGLSPRSQKKDHSSVKSKNKKNKQHRAEITIQKENFQPAEATTFQIIQPEVVHSIPFQGPDGVLMAPPTPIPSGRVVASPLPGPRKEKSKAKQDENTSKDSTGKESKTSRGNKKKRKERSKSPQSERDSDKNIKNKDEKRNDQEELTKEYVVPNFEDIEERSRYTQFPSPTKGARSHHPLYESEIDSGIADDLITPPQALNDSFGTKKNNKEFHDILVNGVNSSALDENEELAGQQAFNKGNEGDPHAKDSKTMRGDGKGEQNIAKLSDKDGAGKDGVGKDGKTSHKKTKKTVKKTVKKTDDFDEKLKNLKAVEPPPLQIPDHGDMSLEKDTPSAKDRKHKIVEELRGELRKTKNERVDLEKQRDQKVRKAKSLQTQTLQKRNQAKSIWKKKFFDEKRKTAPLEEQLNRLRYDVEVQHKAIVSYLETNRERDGVRGTQDQEKTPSEKTNQLMLLAKMQNEVEELKHKVEETKMRLASEMKLRDNAQSELKQLREDLLDKKINLTLTKSQKSLLLLSNQENITAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMG5</accession>
    <name>A0A6P8IMG5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Kinesin-like protein KIF21A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116302798</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568029.1">
        <property type="nucleotide sequence ID" value="XM_031712169.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IMG5">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="GeneID" id="116302798"/>
    <dbReference type="KEGG" id="aten:116302798"/>
    <dbReference type="InParanoid" id="A0A6P8IMG5"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22248">
        <property type="entry name" value="Rcc_KIF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000164">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000011">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056533">
        <property type="entry name" value="KIF21A/B_hel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23204">
        <property type="entry name" value="KIF21A_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13 17" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="20">
        <location>
            <begin position="9"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="1307"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="1536"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="1578"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="521"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="794"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1073"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1163"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1218"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="368"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="607"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="892"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1100"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1228"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1261"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031568029.1"/>
        </source>
    </evidence>
    <sequence length="1626" mass="181338" checksum="A5002F4E8ED95A4B" modified="2020-12-02" version="1">MTNKGDDTSVRVALRIRPQSAAEQINMCRVCTTVTPGHPQVILGKDKAFTFDHVFNVETIQDQVYNTCVKDLVNGCLDGYNATVLAYGQTGSGKTYTMGTGFDVNIDPEEEGIVPRAVGHLFNGIEKRKLEAKQRNEPQPDFKVTVQFMELYNEDLIDLFDADGRGRKANHVKIHEDPNGLIYCMGVTMKNVKSALDTLNCLQQGALLRTTASTNMNTHSSRSHAIFTIQIKQQRVVRTSEGDKGSNSNYEYEMLSAKFNFVDLAGSERLKRTGATGDRAKEGISINCGLLALGNVISALGDVTKRGIHVPYRDSKLTRLLQDSLGGNSCTLMIACISPSDRDFMETLNTLKYANRARNIKNKVVVNQDKASKQISMLRAEIQKLTMELVEFRQGKRVSNMEGESDVTLENDLLKSENEKLRMRIKALSSTVDSQSYRITDLMSAKAMADLEGVHVDGGVENLIQNYLREIEELRNKLTQSEVMATAITRNNYLKSRTGHAVSTDSSTTILELAKSDLAKQKQKAQKLRKSSNSTKEENEETKENSSDDELSSGDEEDDDEEEEEDVDDNDDNDDSEEKGKDGSGDESSSSEENEDSEAGAQVVEELAELTTEIEIKEKLVEELEASHQRMLIMKTQYEEKLSLLTHKIKETEVERDQVLRNIKDQDSEAAKQAKHIKEEYEKKLSNLKTELKKLQVAKKNHAQLLRDKARNEQQLKIYTNELNEMKKVKARLMKQMKDEVAKSKQHEMAKNKEIAQLKKVSRMREIAIRNLETEKRQKELILKRKQDEVKALRRQQKPVSGALGAKKNQVTSQPVNGNEPQAENEPSGYGTYGYRGSSVYNKPYGGPPRIGLAAREKRKRVTIEQAIKMAKKKWDHIERKVGALVIQRQTISNLEKDMDRWIKNRNELSKQLEECTNKYNKAKEDEEDESIIQELKDQLEAHTLHMDYIQENIDSCQTCIIEMEDPGNTTTELNELISSCMLHEARALSTHFLSNIISLGQIISAKEATIKELEGLLEITKEHNTIQQTLLSHVLAQGRSLSAENLASGADPVTLNNVNELLRLSTGSLHSLGGGTDDGNLSSGSGSSKSRDKARRRTGCREDFLYPERVKAKKSPSLNSLKDNDDTNGPLVPTGATEFKPSKQISPELMQKLLELDKARKDANDNRAMNGNVKSSIIQSISDTSQSQEGDGKDIIPAGYQTLPASLVRGNLRSKSARNYQSSKYGPSPATSQQPKSQPSSPTMSRKNFDRNQDIGNDDGGSQKNENVFSRLTSNLGNDSDPDVGRMLPLRPPTGKPSALVCTYAATGHNSAVLSVDVTDDYMFTGSKDKTVKVWDLNTGEEVMSLSGHKRDVVAVRYCKLTKILYSVSQNIIKLWDLRQESGKCIKTLSPQTGSSISGFISGITSDTQINDLQISSTATSLYAAMGNTVRIWDLKMYSMTGKLGGHAGPVMAVLERRRDNDTLVFTGSRDHFIKIFELGEGSAGVQTSKYKLEPPHYDGVQCLSIRGTALFSGSRDNSIKKWDYTTQDLQQHLIGAHSDWICALDFLPQSSVLLSGCRRGVLKLWQSDTCQQICEVKAHRHPINAITTNSSCVFTASSDRLVRLWRVTGTLEEQLEDLKQSVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN82</accession>
    <name>A0A6P8IN82_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116302971</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568267.1">
        <property type="nucleotide sequence ID" value="XM_031712407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IN82"/>
    <dbReference type="GeneID" id="116302971"/>
    <dbReference type="KEGG" id="aten:116302971"/>
    <dbReference type="InParanoid" id="A0A6P8IN82"/>
    <dbReference type="OrthoDB" id="5977099at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568267.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39613" checksum="CB7DDE07FD6BD856" modified="2020-12-02" version="1">MSSVGSRAEFPNRVYSPTPEDDFDNQELRPLNPHLPLSYEEMNGADDSYTREGQLHQYEDPRLLAEQMRRMNNSKIPPPCDHEIRPRKKANDLYERYRTDSDGSDSSKKSSRCRGAMCFLVTLSLMLALAAVLMAVLLVLGLLVPKSCENCLKNVQHSEGVPRTGTSASTPSTKHLEQMIKILQANLTQLHQIVRHRDDVIKKLMETDKSHTEQLNILFRNQLSDILKNARYNVTAQLKKELRGERGPRGLQGERGPPGEPGKPGSGNISTCVYKVAQVIFSPSRSSSQDVFAYQTSGWLIISATCSTDGAAQSNLRRVEGPNGIQKYSCQCKGIAVAHQGPATCFIHYWQCPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ING2</accession>
    <name>A0A6P8ING2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031568357.1">
        <property type="nucleotide sequence ID" value="XM_031712497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ING2"/>
    <dbReference type="FunCoup" id="A0A6P8ING2">
        <property type="interactions" value="2428"/>
    </dbReference>
    <dbReference type="GeneID" id="116303051"/>
    <dbReference type="KEGG" id="aten:116303051"/>
    <dbReference type="InParanoid" id="A0A6P8ING2"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="117"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568357.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32314" checksum="12013B81EB5E38DF" modified="2020-12-02" version="1">MAANSIVKTISEDSLFKPELVNAGTKLVVVDFTASWCGPCQRIAPEVEKLSRKYPNVVFLKVDVEVCQETAAKQGVSAMPTFQFFKSQTKVDEMTGADHMMLENKIKQWKGDDGEEGGGCGVKGHVDLHSFINKSGCESLNEDNEHTLADALSKGPAYLQSDCDEQLLFTIAFNQPVKIHSIKLQAPNDGKAPKTIKLFINQTKTLDFDSAEQFTPIQTLELTADDVKDDSIIQLKYVKFQNVQNMTFFVKDNQGDEELTVINYLCIIGSTVDTTNMQDFKRISGKKGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPA5</accession>
    <name>A0A6P8IPA5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pinin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568305.1">
        <property type="nucleotide sequence ID" value="XM_031712445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPA5"/>
    <dbReference type="GeneID" id="116303010"/>
    <dbReference type="KEGG" id="aten:116303010"/>
    <dbReference type="InParanoid" id="A0A6P8IPA5"/>
    <dbReference type="OrthoDB" id="5981556at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568305.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="70177" checksum="343C386F88B79F79" modified="2020-12-02" version="1">MRQNLVYVFTKFCKNLQSPFREILDTCLEFNLAGFQKRVNNNQTDHKTKTSRTLQFSRKGSHSKISVQNVSDGTTNICKESYAMYTTERSEHTQVKRVRFVDPEAIVRKIMLRRLLSLRPASKNDSKQDKAESTSISNEVDKNSKTCAVEETRTKTEICCKVKNVEETLDVADNKLVIEEVSRKEQLINSKEEKNEDVTKTKDTDEEELKKNTNVSEESEEEKEKKDDEKETSTAEEGESSTESLPESEVDSNAESCHSEFRSDPEGKDSGIEKGESPNLLHQDINDEDEVEAMSEDDEAIPEKPKQDALISVLKNSRLAAKTTLQVMSPAITKKRFAKRGKIPRRLAKENSGFDSEQSNDSSPEKRYRGKKNMTVSYLSYPQRYVRSSLAVEARLSQWRKETSVVEGRDSTATRKLKQTARNTLRNSMDQKREKFKGKNVNFSESRRASESSDTSSDEDVNQMSVRKIYNSKNALRRRIENLEGKLQSMAVQKEGLENLVFIMNVWAKELSAVERTKLGVPYIRSIKQVLKRHHQSLNSRTSDFGELLALLGRSKIPCFDDIHKMVKQLNKNITSIVQDRKKYSSRHIEDLRQIQGKIIGICSAVKAVYYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPX2</accession>
    <name>A0A6P8IPX2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tyramine receptor Ser-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116303519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568934.1">
        <property type="nucleotide sequence ID" value="XM_031713074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPX2"/>
    <dbReference type="FunCoup" id="A0A6P8IPX2">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="GeneID" id="116303519"/>
    <dbReference type="KEGG" id="aten:116303519"/>
    <dbReference type="InParanoid" id="A0A6P8IPX2"/>
    <dbReference type="OrthoDB" id="5972961at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="33"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568934.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34215" checksum="CDCC6F162B97B1C4" modified="2020-12-02" version="1">MNCSSSYRIQTDLATRFIYVLINVFTALLAIVGNFFLLFVVFKSYRLRTTSNYFLCSLAVADFLVGLIASPLNILRIEPSIPASYLPAIGKIFDFCVLQTLMATTFNLVLVSIDRYIAIKWSLQYLTILTTKFVSVAIGITWTSSSLLAFPGLFIYGEGLMIHWLVTVLVTLIFPLGIICFCYVEILKITKAQQKTHAVVLQSGEQICNESEARNNIKNRKASLTFAIITVVFLVSFAPNLICNVFYAFTFQPCSKIPEYFYWTNTIMFISSSLNPLLYGARSRDFRLAFKRITSNFRVGSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQD0</accession>
    <name>A0A6P8IQD0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116303676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569117.1">
        <property type="nucleotide sequence ID" value="XM_031713257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQD0"/>
    <dbReference type="GeneID" id="116303676"/>
    <dbReference type="KEGG" id="aten:116303676"/>
    <dbReference type="InParanoid" id="A0A6P8IQD0"/>
    <dbReference type="OrthoDB" id="5963019at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="18"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="653"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="811"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569117.1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="115755" checksum="8DE91B85DFA13BE8" modified="2020-12-02" version="1">MNKLNSSRSNGECSSLKGLCAFENGMCKFHNADNSSHSWIWTRAKDSPIKSILPKDHSTLTSNGAYVYLLQPTSSSSPKHLVSKSIPAGRVLCIQFWYFIHGSSALKVYTSKTLSIINSWNYKGSTRGKWLFGQTSVKHNTEYMIVLEGGNQHKNDFIAIDDLSFLEVECKSITPDKENLNCAFDVDMCGWKEDQGWKIKNDSSLGSLLHLVVGSQLEKNVTSPLFNPRQDGWKCVTFWFTSTLQLFQRSFKLAVVKEDGYELFILWSYNASVQSITYVQVPLPDMDSNVRVVFRGKKMQSQPVIAISKVLFLKEECQEIKPIAECHSYQVLDSIERRVSNTIIKTSSDKSLHWYTWYRISGAAGNQIPTSCIHENHCGSRTPIHAKSSNPTHKYQIENLFYCKTDWQCCQTTGLLIVRHCGNFYIYQQLSVDTYDEWSQVCSTYKEVVPVYDKSQEWDSWTNTEDNRQWETVYYNDSFVYDSIQTSPDMQEIHMVHDTNIDIPFINDRRNVLSICFYISASNGTFSLSLLYTSLTTFVLSLSNNNVVIKIGNETRSVDAQVFNGMWHHVCVTWESNWGLWYVFQDGYLLGKGMYLGDTIYIQGNTIMLASSGTKGLDKNLLIARISSLSMWSKVLSGDEIVHMSYGCNLYRWDTLLSWNQVVYFTGRNFTHLIHPSTCLGISSSSLILRVKDNTGSRSVGKFQSPWFNQSYDSNKECFMFKYKIKGKEPISLSVVQTLKCPNITDRRVWISNQETGDAWRLGRVLITTMLPYRITFKGQLDSNGYIAIGGLRVASDKECLTSPEKAKYVCNENLYSSKGLITTPNYPASYPPAITCTWNINVQQDQVIRLEFKAFDLEDSEGCEDTFLSVYDGGSLTGRYCGSIYPEILESSTNTLMLSFNASKRNVYHNGFKIYYYSVRESRSDECIQDCPSECTCIKQKDSLVVKGTDLFAIPSPLPWETTAIFFPGNKIFQLKPSDFVNLPLLNYENLKRNKLIKMDNETFNFENKGLHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR48</accession>
    <name>A0A6P8IR48_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Uncharacterized protein LOC116303475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC116303475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568880.1">
        <property type="nucleotide sequence ID" value="XM_031713020.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568881.1">
        <property type="nucleotide sequence ID" value="XM_031713021.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303475"/>
    <dbReference type="KEGG" id="aten:116303475"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11828">
        <property type="entry name" value="SH3_ARHGEF9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF3">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="941"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1245"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="882"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1367"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1443"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1383"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1404"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031568880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568881.1"/>
        </source>
    </evidence>
    <sequence length="1463" mass="166665" checksum="B8E1A33EDD635B81" modified="2020-12-02" version="1">MKLSKYEPTSSNMPLDSEVNDSNDASIPRWKNRLQRFKNSLRASLRPKKRKTSKDLIQDVEDGQKESRKSSGKDRKNWTSLPSVSTRDAKDNKVMFWRENGVEQKHTRLSKKNKKQGSDKPKSTSKLHSMHKKTLSDSQDLNERNHDEWRKYYSHNNISELQTRLPQEEKNHNVSYDVIKELSSTESSPNLKRRWRKKNNQTSLSRPKSLNILTSLFKRSSTSKNELKTNRGNLTKTETLHSTKAKSSTSVPTECDFERKCDPTLSSSSSIESLDDDDFYPIEGTRNIKRHNSLKRSRASLIFPRNSICCQDRGNLREKARTFCGVQDFLALESSPNITEGSDFDSQTAISERRRESCLVKEKKRSVSLVVPLSSSTVDFVHYHLTDNRASLKDFKSFIKTDSSHLRYQRASINNIRSISKRMSMSAQSFANIPSLGVTYVNNDGVENTLVILSGNASQSCYNLFKENERIHFPLKVNYCQGTAEEKVTMGNQQGSRLERSSSFGDFLEQGGTLKATSSTPDLYRAAFSGYTLTRAEEVSKKNMSHMMKGWSLKRHTLTINPKNHDPPNKGKKHRKLFGLGSHHQSKDKKGWTNESNISEAKCKSLSRSVDCLSEKPLPIRRDYKGLFRPPTSSKTATKMEQRAKNCSINCESDYEDASQVSKDSGHDSTTSRPLPMPRGSQLKALDSEDFSAPASFENGSVFLRNYRRYSMGVDGSNPQDSPLIPRMSTLERERSKSALTYPNDPQFPPAVRPRIQSLEELSPVEAEVILRKKKSFASRKTRAKHSLSMPTEELLASVDLSDDVKRYSFGEEMSNFSDAAPVPLTAYKSFSTEFLTSQESLDTINSSSEMGSTTSITSEKLLSPPIFLSPFKASLEDISKSPTIEEEPSSGLLEPDAEKKKTSLSRNPRLGRSTGDLSFELSSTLRRQRDEESMFEEMDVPEAFAEALWDHVTMDPEELSFKAGDIITVISMTNVDWWFGQVGEMVGWFPAPFVRVRVSQELDEIEHQQAQPVRTRKFTNEGLLTKEVVRARVVNELLETEKAYVKNIKDVVEGYLKQAQKRDDMFSEEELYTLFSNIEEIYAFHKKLLAQMKNCYVKDDPCASQIGAVFLANKQGFSIYSEYCNNHPQAIAEFKTLNESNKYKHFFEACRLLQGMINISLDGFLLTPVQKICKYPLQLAELLKHTHPSHPDFEPVSQALKTMKDVAGLINERKRKVESINKIARWQGTIEGWEGDNVLERSSELFCSGEVYKVSNGTTQERICFLFDHQLIYCKKDILRKNALTYKGRIDMDLAIVEWLEDGQETHKNEPLNNAWKIYNSTDYKWYVVYTKKPEQKEKWKLAFEKERTKVNEKVESGLEISQSTRRAVMRSASSSIKGKKSAAERREKYLRSVSQTDALKSPPSPTLRLPPPVSSEDFIKEDGDTKESVVGFLQRTSALRRSFGLRGSKRSHKDKRTSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR88</accession>
    <name>A0A6P8IR88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable serine incorporator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569641.1">
        <property type="nucleotide sequence ID" value="XM_031713781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304118"/>
    <dbReference type="KEGG" id="aten:116304118"/>
    <dbReference type="InParanoid" id="A0A6P8IR88"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
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    <sequence length="684" mass="76993" checksum="6F61D95B49CAC2F5" modified="2020-12-02" version="1">MGAALQTLGLXEVASEIACCAGSAACGLLCKRKGSNTQGARSKLIFLLFLGLANVMSFIMLVPDMRKHLDSIPYLCDTISSPKMCDNLVGYSXAYRVFFVMSVFFFTFSILTYDVTSTKQFRARLHNGFWYIKLSILTLLFIAAFNIPNFSQFGMIWMYVGLTGGFMFLLLQVVFIIDFGYSWSASWAEKMDVLNTKCWFFALAFATAIVYALSLCAAAVLYIYFTNPVDISQCKANTFYISFNVAHCALATIISILPQIQQEANGAGLLQSSVVTIYTMYLTWNTLSSQPDSMCNPLGDVILEYDKASGVNGQAVFGSVLTFALLTFACTVRASTSQLGKLGLALSDNPEYLRKSRQVNRRKSKKENTSNRKQYDXEDQEENEDIAYSYSIFHFMLFLASLHLMMVITNWHSPDEAEDFKKLIKNWSAVWVQMSASFICCLVYIWTLVAPLIKRTWXDVLGLEPEPPRRPTARRPSVHQLKKDLKDIQERRKSATINEPFVRQTGLANELKRRNSPSKNTASESDLATRAVSESPSVKTRKELGQSEITIHKGEHHTRDINESTFGPETTRADAMHIDLPMGRSSPILEEPNEIRVASAASGRVSDPLRPVAIQIEHPFVRTAKTVDLNHQTNPETTQQILRLQERILRFQAKIVKIQHKMLYLQQTGEKLESPVRQVEAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISI0</accession>
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        <name evidence="12" type="primary">LOC116304273</name>
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    <sequence length="328" mass="37067" checksum="A24E7082D63FDA68" modified="2020-12-02" version="1">MNTTSSTSQEGPAVVVVYSVALFVVIVLALLGNSVVFVAFYRSSALHNASVAFILSLAVTDILVASISIPIWLSFQLNQCFYLSNVLCNKTTYTVWKCVDVLFSTASIMNLCAISIDKFIVITKPLHYPNIMTSKRANIALAAIWIFAVSLAALVTVHWDFFPTFVFIVSFIFPSFIMIYSYSRIFKTALSQARRVFPIRQTYYFKRELKAAKTLAIVMGTFIACWAPFFLVNLIVSYRPDLFPSAVTTAGIKLLHYINSALNPLIYSLSNKEFRYKILRVLPCKLGRRNNTHMIDRVVFWSTTFSQSADLGNTSFPRQKSLRVNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISJ3</accession>
    <name>A0A6P8ISJ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116303751</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="primary">LOC116303751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569203.1">
        <property type="nucleotide sequence ID" value="XM_031713343.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:voltage-gated potassium channel complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="K_chnl_dom"/>
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        <property type="entry name" value="VG_K_chnl"/>
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        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
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        <property type="entry name" value="Ion_trans_2"/>
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    </dbReference>
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        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="420"/>
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    </feature>
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            <begin position="165"/>
            <end position="183"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="228"/>
            <end position="257"/>
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            <begin position="172"/>
            <end position="252"/>
        </location>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF07885"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569203.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47772" checksum="55349C117C8EAEC3" modified="2020-12-02" version="1">MEFLKFLLILVLSSRGTSDCQDQQRVNMLLNNHFPLYLMKDEETRTPGVDSKGMRNVYHGQLEKGINEVISRCPQKCTSIEWNNALINNADEVIKRLHENTTAMFVFPIPVEVGKKISQYYHNDSTVQVIASQKQSNLIMMVDIGRCREDLSYEIFQIIRKQSPILPIVFLLAAIAGVILWVLEARQNAQEFSSSFFRGTFDGFWWAFISMTTVGYGDKTPRTVLGRVFAMIWIIMGIVIISFFTATIASTITIATVEKSCHTLKNRNVAIISNDTKVKDYVTEQGAKSIKEFDSFPAMFKAWRNKEAGINSLFVEEHTALMYFYGRNDNSAIKDVRVTKSTKDVKQLTLFYVVVKKSPSTGSALCGLNTLDLKELLTVPDLPKPPEMLLVTKWRRVLLPSFDFVNFNSLLTISHKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISM2</accession>
    <name>A0A6P8ISM2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein unc-45 homolog B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116303768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569228.1">
        <property type="nucleotide sequence ID" value="XM_031713368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISM2"/>
    <dbReference type="FunCoup" id="A0A6P8ISM2">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="GeneID" id="116303768"/>
    <dbReference type="KEGG" id="aten:116303768"/>
    <dbReference type="InParanoid" id="A0A6P8ISM2"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043195">
        <property type="entry name" value="TTC12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46540">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46540:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031569228.1"/>
        </source>
    </evidence>
    <sequence length="700" mass="79297" checksum="4DBDCF1979C39203" modified="2020-12-02" version="1">MTSEDASSSEAAMKEADKYMKDHGIKDDDTILDTTRINKQDKQQSTYASEKEKEVVNCSPEDFMKAVEEDAKKRATENKRRKMKCEELKEMGNKSFKNQEYEEAIKFYTDAINEMKTNTAVYTNRAQANNKISRYEAAVEDCQTAIKIDKNCVKAYVHMGKGYLYMKEFDKATDTFQNAIKQFPKKETLLKGYLQEVDMERTKLLEESKAIKLIQDNNEEDHIIKSSIEILLCPGQTVNHYSEAALKLLNLIHNSTANKTSFRIHKGFDIYDKDDTSISRFWYGTDPCEDKEDIAMFCLVIDILNEAMTDNEYNVQAFVSVDHSRSFMSLLQEPTSPVIITSMIHLVYLLSQTTNGRKGLMSFESMTRILELLFIHINQGSTNSVVAMSTISNLAFEPKFCEKFRDYLGKEFLKISKMFLGRLCKVCTKGLNDISITWSLTSSGLSAMANMARDTITRELIAKDKDWLAACHRFMCRFGQANVVMNDSDANKVVFALLGLLTNLCSQADLLEEVKCHSLLPSLKDLLDSKDEDIKERCISVLRFLLAYSKESLNIALKEKIYVQFIDMLKSSRPVSVKYALKCLALCTSKDANARQAVLENQGLSSLVGLISSNNEIIIGNAALCLGDCAQIDEVCQQLVDTNIVQDLLRHATNDRLNQDVKRNAVLCLAKLATGDLRHREKLKDLHGLEILHSVFTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITN2</accession>
    <name>A0A6P8ITN2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activating molecule in BECN1-regulated autophagy protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569553.1">
        <property type="nucleotide sequence ID" value="XM_031713693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITN2"/>
    <dbReference type="FunCoup" id="A0A6P8ITN2">
        <property type="interactions" value="2380"/>
    </dbReference>
    <dbReference type="GeneID" id="116304043"/>
    <dbReference type="KEGG" id="aten:116304043"/>
    <dbReference type="InParanoid" id="A0A6P8ITN2"/>
    <dbReference type="OrthoDB" id="6363363at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569553.1"/>
        </source>
    </evidence>
    <sequence length="781" mass="83871" checksum="CB25ED23D1A773F4" modified="2020-12-02" version="1">MKKAKKTKTNVMARRGLFHALLRREKGFPLANDHKDVLSFVEDRTASSCFTEKKCSLSGSPRSTFLVCFSLDKSKMASTHGDHSIRITDSFTGKSIRTLVGHPRTPWCITFHPSSNSLLASGCLAGEVRIWDLMGGCEVYVPPDRAAIASVAFHPTDNVLLIATSNKLYFWKWDQPQPFASLQTNNMEEKVRLVKFSPLGDYILTGITNCSQMDANAQDNRNEASVDQLLQSVSCTQLDSDQVSQYIMQQTSRGDQGATTTSHDRPSTSTSTSNTQPPSSDETDLSSRRRRHLRNYRGVFAIFRARDREGGDWNIDTSEMDNDPTDVGRSNIVFNPANTTESMSIGRVNEPNGSPSSSPFSSSSSSSSSSTSSSSTVRPSSPSSASSSFSSSSSSSSTSSTSSSSSSSSSIVYGDSPPASSNMLSSRVLNFSNDLLQSNTSESRNDEVSQSISVLPMEAARNESDSSVSIDMVDRDSVQYGSAGTSQSDNNFVSGVGSVINVGGTSSSSRTSYVTHGSNHSSSLSTLSNQSGSGTAIATATARTFRHVHTAVVIANGTLEGPQMALRTAINRAIAGAFASSGEGAVASNIINTTHRLQLWDFSKFKMLDLKDSKANVIVPCCKIHNDASCDLSADGTLLAAFVPSVLGFPDDGMLGVYSLKKSSFGQCLFTKKFGPNAISVSLSPLNTHVVVGLAARRIHWHLTSQQMMAQVFKLTPDKDSEVTATELKTPIHNIVLSEEDSLRGSHISVNAAFWHPVVGCGLVYGTNRGDLRMRQFGSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXN0</accession>
    <name>A0A6P8IXN0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305600</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116306044</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306044</name>
        <name evidence="3" type="synonym">LOC116305600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571407.1">
        <property type="nucleotide sequence ID" value="XM_031715547.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571929.1">
        <property type="nucleotide sequence ID" value="XM_031716069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306044"/>
    <dbReference type="KEGG" id="aten:116305600"/>
    <dbReference type="KEGG" id="aten:116306044"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571929.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17882" checksum="EB67FE71214B510E" modified="2020-12-02" version="1">MSKVWRPWDEPGTSQTTSKKTERLKKTPGTSEMSVIKEAWISERTRGWEAVALCAKELILSSHQVPPEVXTYYXKSKLTAIASRCQRCVKSNVHVVNAEKQSNTRERASDEQKSKNESSIQKKDKEPHKLSQKPQTSFLGDSSCDERNADMRYADIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J010</accession>
    <name>A0A6P8J010_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Tyramine receptor Ser-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16" type="primary">LOC116305526</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571320.1">
        <property type="nucleotide sequence ID" value="XM_031715460.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571321.1">
        <property type="nucleotide sequence ID" value="XM_031715461.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571322.1">
        <property type="nucleotide sequence ID" value="XM_031715462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J010"/>
    <dbReference type="GeneID" id="116305526"/>
    <dbReference type="KEGG" id="aten:116305526"/>
    <dbReference type="OrthoDB" id="5971765at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF278">
        <property type="entry name" value="HISTAMINE H2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="38"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031571320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031571321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031571322.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48601" checksum="25E8EB0F66ABB360" modified="2020-12-02" version="1">MMANATNGTGTHILNFEKWYGYMFAGLYCIIIIVATLANIIVCCAIGFNRKLRRNPTYLFILSLAFSDLVTAVFAMPFDAEILITAGKWHHDEALCKAWIVAYLLTVPTSINTLLALSVDRYKTLSDPLNRFRRSRFMTRKRAIIIIIFLWAYCFIVAILPVADVFSTLPFIYEESCLFPLPILFSAITSFTNFVIPLLLTCAIYIKIYQIARLHPLQQQRICSSTFGRPKIHKEYMHNIRAAKTISLFVFVFVFCWVPYSTVSIIGNLCESCFFSIPPHVYPPLLLLGYLNSALNPFLFSFRNRAVKNTLCGIYDCLRIRKSVSAISRSLNSIAKRSELPDNESSTVVRMFSMRSFSGSRSETSPEPNQNETYPKDLQKTDSIASTSRSREPLSCNDKLQLQVELLESSCPQGREKQSYGEYNTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0K1</accession>
    <name>A0A6P8J0K1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-B14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase B14 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116305858</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571698.1">
        <property type="nucleotide sequence ID" value="XM_031715838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0K1"/>
    <dbReference type="FunCoup" id="A0A6P8J0K1">
        <property type="interactions" value="947"/>
    </dbReference>
    <dbReference type="GeneID" id="116305858"/>
    <dbReference type="KEGG" id="aten:116305858"/>
    <dbReference type="InParanoid" id="A0A6P8J0K1"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="14">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031571698.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14770" checksum="101FF6FD238D0B18" modified="2020-12-02" version="1">MASSQVTKTVGRAVVKPLLSTTPGEARKRVFNLYRAWWREIPHAVQAFALDITVKSGRKKVREEFMKNAHVRDLRVIDMLIIKGKMELEETHNIWKQRTHVMRYFKESETPKKTAFLDRFYDGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J101</accession>
    <name>A0A6P8J101_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin-like protein KIN-8B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116305945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571808.1">
        <property type="nucleotide sequence ID" value="XM_031715948.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J101">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="GeneID" id="116305945"/>
    <dbReference type="KEGG" id="aten:116305945"/>
    <dbReference type="InParanoid" id="A0A6P8J101"/>
    <dbReference type="OrthoDB" id="5966316at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000056">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="11"/>
            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
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            <begin position="461"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="746"/>
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    </feature>
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        <location>
            <begin position="859"/>
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            <begin position="1002"/>
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        <location>
            <begin position="577"/>
            <end position="635"/>
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        <location>
            <begin position="392"/>
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        </location>
    </feature>
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        <location>
            <begin position="461"/>
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        </location>
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            <begin position="503"/>
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        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="746"/>
            <end position="757"/>
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    </feature>
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        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
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        <location>
            <begin position="770"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="884"/>
            <end position="902"/>
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    </feature>
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        <location>
            <begin position="962"/>
            <end position="971"/>
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            <begin position="1003"/>
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            <begin position="1086"/>
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        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031571808.1"/>
        </source>
    </evidence>
    <sequence length="1137" mass="128202" checksum="555F1AFA19B5350C" modified="2020-12-02" version="1">MPFKETTHTQNLVVALRVRPLSSSELGEPEIIHVLDENLVVLRDPYEDQDDILRANRSREKQYVFDHAFGPNASQVDVFSVTTKPLIHNVVSGYNATVFAYGATGAGKTYTMLGNDRKLGIMGLTLNDLFAEMEMMKEDVKYKVTMSYLEIYNEMIQDLLNPSTGILELREDAKGVNVTGLSEVEAKTTSEVMGMLLMGNKQRTSEPTAANKTSSRSHAILQVTVKQKSRVENVIQEVKVGKLFMIDLAGSERAAQTKNRGKRMIEGAHINRSLLALGNCINALSENRGHYVNFRDSKLTRLLKDSLGGNCKTVMIAHVSPAGKGFEESRNTLLYADRAKNIKTTIKKNQFNVSYHIAQYTNIITDLRKEIFRLKTKIAEQSVSEIDSNKTTLEEPSEHSKHKDHTEMNRIRNQLVSTFREQMEIRHKLMELEDMAMQIALDTNRYMLVIDEWEQEKVRRAAKNAEMEKERNEKESEQTDRHVYRDHDSKTLVDKNGKPAWEDKDDDEDDTNEDLSDRSNSYEDVENKDLDREKDKKIQVVVQESEPFSMAEPEDVTFAREEINNLIAEEKKVSEMKTALQSKLQQTRKEVERLXEQLPKKISSEENREILSLICKVHELEITNAELQSQALLRENILRYKDLEVSKYESRQKLCDEIIQMQRAVITDAQVNCPTELEGLYEVYLQQSSETDERDSLNSSGPESTTSSAGPQISVNRAAXLAGINRRMTSRENLFTFTSKLSPLTEETPSRLVSLQNSPTKTSRPTPSTYNTFMENALAESSPTSPXHTPKYRSHVSSPDDISIRSSLFLTTPKKPHNDTENHAPLTPVFSKTQKFTDLSTRRRIMMENGLVSSGSLREDLASSKMSSLVSVREKERDRPMASVSDTSLEVNSNKQAVNPSLSLGDLSXIDKKSSDQVSVDSVPVTRRRIAKKGKSEQGKISXPTRPTKRQRSASLDDAKVHRVKPRRTRKSQQEASKLHRPKHQFPSKIRERVSLGLEASSLAGNTNSKRSNIPKAPVHFNDIPRGVARSKDQTKQSRIQSNDVQDGELQTFVSNVTPTSSVRQIGTPPGKGLTIQRRYXAPSDITGSDSNQSTPRVKPRKQQSVGNPPVDALSVSGVAMRPTKPYAGIRRFXELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1B8</accession>
    <name>A0A6P8J1B8_ACTTE</name>
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        <submittedName>
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        <name evidence="11" type="primary">LOC116305750</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="11">Tentacle</tissue>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
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        <property type="entry name" value="7tm_1"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="41"/>
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            <begin position="60"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031571595.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41048" checksum="D353644C7674B7A0" modified="2020-12-02" version="1">MVEPFPIVLRQIMSLPPFRNFSTNLTNEANSESDLLSLNSIMGVFFLIFYISVSLTSFVGNSLVLLICCRSLRRKQRSDSTREHFFSLYIANLAFSDLVFTMLTFFDALYAMQGEWKTGNFTCKIQGFLVETCYTVSILTLVAISRERVTTVSRAEVNSRVQKGKERKIVTMILWIVSILACTPLLYAYSTFFDVKDGVWQCRNKTWGNTGRQVYYSIAALPLFIFPLIFMTYTHLRINKVLKSQVAPSEHMLKAIRSRQRKASRMLGMVTLLFFVLWSPFILLRTLRYFSWYKGLNLWKLSQLLVIASSATNPFVYCFYSTQFRGYFKTVLTCRCTRFVAGTTTEGTTTISNSVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3H2</accession>
    <name>A0A6P8J3H2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116306616</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572558.1">
        <property type="nucleotide sequence ID" value="XM_031716698.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J3H2">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="GeneID" id="116306616"/>
    <dbReference type="KEGG" id="aten:116306616"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041249">
        <property type="entry name" value="HEPN_DZIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16155">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16155:SF19">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18738">
        <property type="entry name" value="HEPN_DZIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZIP3-like HEPN" evidence="2">
        <location>
            <begin position="389"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572558.1"/>
        </source>
    </evidence>
    <sequence length="1653" mass="188380" checksum="EC1A78E94A803D18" modified="2020-12-02" version="1">MDNSELQATAKVSKSNESSIRSTKKKKKKKKKGFRNKDTDDSSIPAEEQPADGGSDTCVTESLFKASTSXLEEVEALKVTKVSDETEKSSRSEDVERKINQQAETGFKDSENSQNDKQKTGGEDDRSSLSTFLDQPEEKPNANGLRKKKKKKKSKGKKGVLVSHVLSEPQDDPGKDKDLEEDNDGEDSKGGSPSEEEAAEDQPEEKPPSPNSSRKKKKKKKSKEKKGFLVSHVLSEPQDDSDKDKDHEENNGEDSKGSPSEEEASEEEKFKAFIHDKEKEPNDLQKFTKEAFLLSTPEKERNNFLQIVTLIYGVGLQALRTIFMDVHPTWSNKPADAKSLVKGSMKLKGHELASFNKGDIDKWDVSLITTVLLYSKKCKDEISKRPGFEDAIRSIKDHKNRLISHISSEKMPDAEFQTYWPVISNDIVTIGGKSEDIEDISKGDVLETGKFYRDLFLEEISSRDALYSKMSVMDKKLDNLLADKYLGSSKADSSPSLKDLSGPKWDEWLRFCDRVSNFDYHQNNYILITDAMSRENVQHFSPLRSVPWKVVLDFDPCSEEKGLYHDFINKEGKISLINMITPDEIRRQHTTNLARHLDSHKTQWVFVNGREKDKIGCQQTLEDWKTSSVKQLTKFFICYSDPDKSDKHKPIVCLVLPFRKETVPYLTITMERLTENFDEFNINFVGTQQDQCDILRKFNIQITKLNPSLLSLGMSELFHESSVTGYRMPTCQAQMPVRLKQQEYLYLKEYMTVLYDGCEDLPSVKGDIEEENKLEKMLNEHRESFMSGNWISFISLFDNHDARREIGNAVRTHIQRLLDLGPTHSTIVELCHSPGTGGSTIARRVLWDLHKFFPCAIANMEGLNSDFDDDLVWINGLADRINDLHDLCRTIPLVLLDGKHARMEAISNKLVRILNNRGLRVVLLRCLHRSKGSDIESTSEASNVHARFSVNVKLEESRADLNEFEAKYKDFIEDFTKNKTTSSLCRVFHFPLIAMLQGLEGFGKKLEHIVYDTFDEMTSFEKEIAVLVAFIQKYAAQATPASLLYKAFKPHFGHECDTNKGTTYDDINQPITEQLLNLMVPTKPASVRRGGSRSNVSSFHESYTLQHPLVADLVLKKVYMDQKRNIIALTREFLEFPIFQDERFFSLINDIFIRNRSSAANARFSILFEELKSVSSSIAAQIFCEVAEKAKDATLYGHAARFHTKKNPQSFSTAKELIAKAFQCKNAKHKIRSIYDMKGGILQNELKFLANTHKIDSLPSLQKLADEALQSYKKARNFPPSFPNPLLGEVKVWIACIEWITKYQCNGDSDETIKFLNSANAPPFFSTCVSDSFYLLDIVDGIVQSAVTLPDPEETQRQANTLRVSLMRTFNKGRRAPVGRKDKDDVIQACIALCSTENFPKSSHTELKRLQAHYIISCVDGQIENIKKEHLEFLVKLLESLVLVENEGSSMAYHLMKVCLLITEPRHYSLEKGLRVAEKWIQESSYNPLPYFYQMMIYFLKILDGNHLLYRDSYHKAINKCQENSQHHCRGAMSTHFLKRKGKGMNRLMTKSALLSGEAEYPRNVKDFWTIHSRKKLLECRGRIRIRQKSGRRKQVYIELAQGNIELYVGKNADIGQVERDFSQGSIVYFVVSFNLQGPVANGITFTPSTEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3N2</accession>
    <name>A0A6P8J3N2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116308005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116308005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574214.1">
        <property type="nucleotide sequence ID" value="XM_031718354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3N2"/>
    <dbReference type="GeneID" id="116308005"/>
    <dbReference type="KEGG" id="aten:116308005"/>
    <dbReference type="InParanoid" id="A0A6P8J3N2"/>
    <dbReference type="OrthoDB" id="5984651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="114"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031574214.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43241" checksum="D4C020C5F4ACD2DD" modified="2020-12-02" version="1">MNVLKRFLQECGEEREIENIPPPQLDSLLSNFYIKAKKKDNTLYEPDTMSSFSRSIERYLDDKNAKVNILKDEEFKLSRQALMFRRRELRKEGKGNKPNATAPLTSKDIDAIFNENEFGVHDPEILSRTMWFLLTLHFGHRARHEARQLLKFGDVLLKKDEINGEEYVEWFQERETKTRHVDENEHQRAFRPRAYESGDKKYPVACYKQFVYRRPEEAKSPESPFFLAINHRRRPNDQVWFLNGPMGKNKIGEFLSQATKDLKFTKSKAGKITNPSVRKTGITTLLDAGVPHNIVAQLSGHKSLDSYAVASESQQRNMSKILSGVENVKHEASSKQLCLGATDYKFNCRCRFFVWGSKHWSIEHSESCSFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J485</accession>
    <name>A0A6P8J485_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cholecystokinin receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574429.1">
        <property type="nucleotide sequence ID" value="XM_031718569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308185"/>
    <dbReference type="KEGG" id="aten:116308185"/>
    <dbReference type="InParanoid" id="A0A6P8J485"/>
    <dbReference type="OrthoDB" id="5957048at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574429.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36401" checksum="B29576232F336649" modified="2020-12-02" version="1">MDLDQGTRLSIILVIFLLTSVSNASVGVMMYRFKNLRTIPNLLILSSCIADILNQFFNIPGFAAGYIARDNEYFVGRSLALALSTFHLFFVLVNLMSMTLMMVDRLCAFKFNLAYRVWRTRSKAYKAIAVKWISCFVISMVVLVPIWDIDLGNVATYKYRNIHFAKRGILITFIIFPCFIVNNAVVAIXTCSVMKHKTKTNARKMGLNADSVLDQTRKLSEMNAMKTIGVTVMVFFVCYLPGTVYGMMDKMKVISTNETSWFGFGAYSCLFLPGLLNPFIYAIRTRRFRRALECLLKDPFGSSEISQSVDLVLDSLTLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4I9</accession>
    <name>A0A6P8J4I9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic aconitate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Citrate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116308622</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031574956.1">
        <property type="nucleotide sequence ID" value="XM_031719096.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J4I9">
        <property type="interactions" value="1257"/>
    </dbReference>
    <dbReference type="GeneID" id="116308622"/>
    <dbReference type="KEGG" id="aten:116308622"/>
    <dbReference type="InParanoid" id="A0A6P8J4I9"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aconitate hydratase"/>
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        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
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        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
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        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
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    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
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        <property type="entry name" value="ACONITASE_1"/>
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    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="13">
        <location>
            <begin position="69"/>
            <end position="595"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
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            <dbReference type="ARBA" id="ARBA00012926"/>
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            <dbReference type="ARBA" id="ARBA00020255"/>
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            <dbReference type="ARBA" id="ARBA00022485"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00029682"/>
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        <source>
            <dbReference type="RuleBase" id="RU361275"/>
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            <dbReference type="Pfam" id="PF00330"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031574956.1"/>
        </source>
    </evidence>
    <sequence length="813" mass="89284" checksum="D2EB90C97D5DDF9C" modified="2020-12-02" version="1">MANETSTYQACLKTLSLNSKELKYFDVASLNEERFARLPFSIRVLLESAVRNCDGFQVLPKDVENILNWEENQQHNVEIPFRPSRVVLQDFTGVPAVVDFAAMRDAVKRLGGDPSKINPLCPADLVIDHSXQVDFTRSLPSKLYDPGGVWPAREHNCPFHDLPCECSGSLQKNQDIEFERNKERFQFLKWGSKALKNLTIVPPGSGIVHQVNLEYLARVVFNTDGIMYPDSVVGTDSHTTMINGLGVVGWGVGGIEGEAVMLGQAISMVLPKVIGYKLVGTANQLVTSTDIVLTVTKDLRQRGVVGKFVEFFGPGVASLSIADRATIANMCPEYGATIGFFPVDEKSMLYLKQTGRDEERIAMIEAYLKASKMFRDYTNTDNDPTFSEVVELDLSTVVPSCSGPKRPHDRVPVSEMKDDFQSCLNSKTGFKGFAIPAEKQADKVPFKFEDQDFELKHGSVVISAITSCTNTSNPSVMLGAGILAKKAVELGLSVAPYIKTSLSPGSGVVTYYLQESGVMPYLEKLGFSVVGYGCMTCIGNSGPLPEPVAEAIEKGDLVACGVLSGNRNFEGRIHPLTRANYLASPPLVIAYAIAGTVMIDFDKEPIGVSKDGKQVFLNDIWPTRDEIQVVERKYVIPAMFKEVYSKIQTGNPQWNELEAPDSLLYPWDEKSAYIKSPPFFESMAKELPEIKSIENAAVLLNLGDSVTTDHISPAGSISRTSPAARYLAGRGLVPRQFNSYGSRRGNDAVMARGTFANIRLVNKFMGKAMPKTIHFPSGETVRNTFPNRLSSSLGLDELLSRGYSCPFRVGMCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6D2</accession>
    <name>A0A6P8J6D2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Daple-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116306894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hook family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572885.1">
        <property type="nucleotide sequence ID" value="XM_031717025.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J6D2">
        <property type="interactions" value="2234"/>
    </dbReference>
    <dbReference type="GeneID" id="116306894"/>
    <dbReference type="KEGG" id="aten:116306894"/>
    <dbReference type="InParanoid" id="A0A6P8J6D2"/>
    <dbReference type="OrthoDB" id="10254988at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22223">
        <property type="entry name" value="HkD_HkRP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hook homolog 3 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1799"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1912"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2257"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="241"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="583"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="835"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1233"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1592"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1826"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1936"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1978"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2019"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2052"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2116"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2163"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2185"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2215"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2257"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2320"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2351"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2383"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2435"/>
            <end position="2446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031572885.1"/>
        </source>
    </evidence>
    <sequence length="2472" mass="283740" checksum="10E8EC486A6CED77" modified="2020-12-02" version="1">MSTVAEFFGNPLVTWVNTFKNNSPAETINEFADGVFLNEIMVEIDPTYFTLTRVHQNVDGDTNIRIQNLDILVRHLKAFYQEKLQQVVLLRAPDVVAIAHHPDSDVGLQELIKILLLMLGCAVQCDSKESFIEKIKELDLEVQKHLVDCIKEITENPSHVLTFRPNELQDSPMEHVIDVAESMFYQMCHLVEERDQNYGVITHLSLEKDSLLQEKQRSKSPRPFSPPPSVAAQLSADSPSLMASREKIRMLTEELEEKNSLFAELKEEMLASKKTVERLRQENKLLSQDAILVKTYRDQMDMLKSKADKVEKLETDAAKFKEKLRDLEYLKKRAEELKEENQLLYDNKVLLEGQLSGMSSKEERIEFLEEENKKLKSHIHHLAEERQYDQEKMKEVMASNAQLTLEKQESMAEVFSLSAEIEVLRGKSPLGSVNLASECNESSSMDVLRLSHQNQHLKQSLEDLRGASAKLIDLERENRTLHDKYLEEKSTNHRLSQELAKFKVENKQRGTEVEKLTRSVRALQDELHMSSGELKQRREVIAHLEQENYSQATELEDKTKSSQDQEGNVASLAERAVIKDKELSKLANKNNEKEAVISDMKKRIQEKESTIEELSDSLAGKERQLKSLQSRLDETVEEQQKGDEFIRKQKKEIAELENRLEETLHEKKKYQEDVRQRESEVQDYTQRLEEIQGTKSKSDENLKRKDKETYELKNRLQSAVEDSERLSDEIKAKDQKIQALQKKIEDLSNSLDESNEDFNQKMREKEKHNKQLERRIEELVESLGEVEKMKDTVKQKDEKIVQLTSNLDVKDKQNRELDIKLEDSNSERNKLLHTIKLKEKKIDALESSLSEIENSSVVAKDDRITEMKKALEVRDNRIVELENKLEDLTSSNNKLQHGTKLKDEKIAELESRVEEIESLTFEKTRLSQNLDLKMRQIIDIESSLEDFKGENQRLLHSCSQKSTKVKELETKVRELESYVELSQGLQQTLKHKEEKISTLVSNMQVQDERLTELEHCLEDEKSQNHKLTHSMKIKEEKIASLEKRMEESEVIVNESFKLSQSSHQKDERIKALEDELDELDDIMTTNEKLLKSVKQKDDKINRLQDRLDEVEDAVNLNNKLNQYLKHRDDKIKALGKRILELEATLEMKEREQIANAQANYTKIRELEASLEAVNSVKVQRQNSVKRREDKIHDLEYRKTKLEEYVQEREAKVHALQSQLDGSVNRYRKMDMTIGEKDMMIAELEARLSEAKEAGRENNKLNQMLKAKDARLTELENRVQSFQSSMSNTQLQEKERNEKLETLQKRLEETLNLNNKLDQSVRKKEENIRTLEKTLQSYEKREEELEVLLETRTDKLSGSKKRVLELMDMIERKDNEIEELRKRLEEFKSATSSEEIITAALKEKDSQLADITRNLEEMEEEKRKMANKMKLKEQKIETLEKQIEELDVAKYNKDEKRTIKQNETRISILTQNNKKLESDLYNMESKLEETNSQVNKLSRTLDQKEDRIKSLKSRLEDAVHQNNKLNHALELKDDKIKNMEDRLEESSKQIVHLREGFQGKTPEKDQKPKNTSTSIIFKPAYNSRDDRKTVQMLSVADKRIADLNEEIRALEKQNATIKTQSEAMSSRNAQLEIEMESLRMELQITKGDYACLVAELNEARDYYHQLDLSATTMGHRCEMLSQLNATLEEENKALHDKVSWLMGQNRELMVKSLEEKDQFMEEERIFSDRLYNLQRTKEKLEEQIDLANKALSESAPPKKKPGFFKKVFQKAGLKKKKDESNKSKNPVQLLKVEYSDDVDTSILSGSEHPDDSLSSLHGTPGRRYDESSIASRESSTSGDSSRGTASKSAFSPNLGPKSEVVMRKGRNQPNYPAVASTSAMMSTREIEMVQQRKVSDVSAFRARQVRSEIFADNFNPGRLNRPKSLDNLNKIGGFRGSNDTLSSGSAVESTPNRSSRGHARITPPSSPINAFRVIPQQNSSPYSSPKTSKKGISSRSSSPPTNKSPVVPRRMRASPMSSSVNDRSPQYSQDSVRDPSTPPRSRRSSFSSAISGHESDQEMERIDNMSVSSMRSSIVERTPPPYPRDAKDESASKSKRSSIAERGPPPPYHRRPASGLDAEKREDSSPHSKRSSTAERRPPPYPRGPETDFQPEHPSARSPYALNRSASFHSRSGVSREEQTAVTRGSKRESLREKKTASLESREQAPRHSPLQTTTRRNERMPHTKDSPNAKNFDSSVDSESEVLIDATESVVSAVPLSPASSIASPNNVVSPSDNSSSTVKVASYIRQNESLQESPLRRMNSIPRHNARSRSMDESSPLKTRKEPTKADKGESCFAAVMVRQKSLTEEPLPSSETRSSDVASGANNVVRARVTSFEQQKPEQIPKSSTLSNLPVQGSPIRNDDDEDDRWSKISSGTDNSHSRRERQGASSPNSQTQRDDNQSEERSNSRNSSRASQQRDRKGTTHQWLEYGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JA02</accession>
    <name>A0A6P8JA02_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574568.1">
        <property type="nucleotide sequence ID" value="XM_031718708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JA02"/>
    <dbReference type="GeneID" id="116308317"/>
    <dbReference type="KEGG" id="aten:116308317"/>
    <dbReference type="InParanoid" id="A0A6P8JA02"/>
    <dbReference type="OrthoDB" id="188749at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056704">
        <property type="entry name" value="DUF7802"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982">
        <property type="entry name" value="AGAP005361-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982:SF1">
        <property type="entry name" value="SPIROCYCLASE, AVEC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25085">
        <property type="entry name" value="DUF7802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7802" evidence="2">
        <location>
            <begin position="9"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574568.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48719" checksum="C4AA29166A563E81" modified="2020-12-02" version="1">MADASGFLSWFISFRNPIEIWKNEPTFLLCEIVYLLMAAMTLKHAVRHGGCNILLWLAICLHGLTTECVSYFVPDVDNFWHAQSTVILVEKRLPLHIFFFYPATLYTASIAVSKLKLPFSAEPFAVGLADVLLDFPFDIMGIKLLWWTWHDTDPNIFDRHYWVPWTSYIFHMSFASSVAFIFHGMRRLLIGAEKYQPSNSWFKEVVCVILTGLFSMPLGVIQFIFFYHIPHDVYGIHTEVVVCAMIMVYGLIVWRSDRNPDLNSRGDSMSAYDVSKKKIGQSKEKRVFDEISFNVILHFLFYLLLVVFAKPENMKSTGLHQEIGNCTQKTPVHTPLGQVLYKKTYLCSSEYDEGYFDWHCTPDGQPPVSGSKWYTLCGLPYPNHAEYIFVVSAFCILGFTIYYQMLWCSARYVASGKKKVKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JBX1</accession>
    <name>A0A6P8JBX1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308790</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575138.1">
        <property type="nucleotide sequence ID" value="XM_031719278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308790"/>
    <dbReference type="KEGG" id="aten:116308790"/>
    <dbReference type="InParanoid" id="A0A6P8JBX1"/>
    <dbReference type="OrthoDB" id="5947018at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF4">
        <property type="entry name" value="CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027746340" evidence="1">
        <location>
            <begin position="31"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="2">
        <location>
            <begin position="103"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575138.1"/>
        </source>
    </evidence>
    <sequence length="715" mass="81579" checksum="3C3DE05459783D15" modified="2020-12-02" version="1">MQPTMGFKDVNIAETFWYFLVWFLLAVVAASNNTSLNVTNITVSSTPPLLKDTSSCVFPNFLQTDCTGLAKVCEWNLGKRIALPQWHNLSPPSKFRALQGTSEWTWTVVNSTITIKQSIIAKXFQPLSRITHSVFECIANRGLANNTFIIFKKEILGGKQDTNKTFSCVRFLKRSETVIQYELGSWSRRLKDVACQDNELVLQEDLLISDHSHGLVDCPLELGGAHEIWHIYDAKEQRTCTYAKGSFGVLESDCLSKDGLYIDFGKGHNCTNPDIGHXFPLELNLRCISKWKDGLFTYFVTARRDRWVXDYEKTTLQCARIKMTPDLEDELTLTIFNDPICKGIIDNGERVGRNDDMYSLRIRRRKRPYNSKYHLSGRCDFPNEIQGTWMEQSAHQGSKKIVINGGNISVSPYGSFECKERFTISQGHPSVCGFVPEGDRWLGQGRVRFYYDDYALLSQFENGCRPRITRLGLTSTINKHVLIYRLSQSEPLVEDGRSPDDFYRHEILKRFCGMPYLYERDPFPHWGRNVEKVIHRELLPAQPMSKCSLVLNSRHSLLSVVAGVESTSCTGKSSLMHFGCQEARQKMTFLNISYPPSCKEKEVTFSCIGKAWKFGNNVLLRDAVTQQINCFWFDKESNAIFRLGSPQCSDADWGRLPGHANHFDERFSIKYFEKCPLXAESSLKPTKGGKSRATFAALTQTLWLLPSILLTRCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCE0</accession>
    <name>A0A6P8JCE0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bicaudal D-related protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574245.1">
        <property type="nucleotide sequence ID" value="XM_031718385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCE0"/>
    <dbReference type="FunCoup" id="A0A6P8JCE0">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="GeneID" id="116308034"/>
    <dbReference type="KEGG" id="aten:116308034"/>
    <dbReference type="InParanoid" id="A0A6P8JCE0"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006933">
        <property type="entry name" value="HAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF13">
        <property type="entry name" value="BICAUDAL D-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04849">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAP1 N-terminal" evidence="4">
        <location>
            <begin position="66"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="83"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="498"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031574245.1"/>
        </source>
    </evidence>
    <sequence length="682" mass="79834" checksum="850CFF7888D92AE3" modified="2020-12-02" version="1">MKSKTDLIRILTMGDCEETETNEELLLDEGSELDEKQHYNCHYDLENEFNGDDDYDEEDDEEQDLYVLLAQKEKDLLLAAELGKALLEKNEELSQKYERLQEEYSQQAEELEQEKYELRLRIERMSGAHESRVQELQADIQSLRQELHSHKSASLTDSAHKRKTFAGLTEENEKLHSELYQLRTKNETLSEELNNLKRQQLSRTFSIDDVHNQQIEIEELYEKISSQEEEKNSLRQNIEELESTKDFLAKDNEELRGKEQDLKKNYEDIKTQLEDVKDKLNESKTNNLHLQDQLDEMKIQASLDQASRGSLFSELSDMSVSLLDNDDLCVKSERKTKESTQRRLPVLSVNGSPRPLAASSSNKRPRQYFSVDSDEEDSDDSDLEYDENECEVDGPVTLRNTDFYAQLEKEQNTNAELKKEIIDAHNELQLYYDRLRRHHDKPTAKVEPLDPNRDYQSGCLTSFVQNFKAVLDEIIHSHKATVMRKNSGYAGSMVGSVHENLKEQISNLKESLYETNKDMEHLRENVATANKRINQKEAKIIELQDKLHDRADEIKHLNEERRRLVLKECDPNLVFDAVYQQAIQDKEEALRRESETSMELEKSKREVERLDKQLMEAIQQKIELSKQLEEWQYDVASLIDEQVQKQMRTVASEGEETRTRRKLFSKGWNWSTSSPKKQAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JD53</accession>
    <name>A0A6P8JD53_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116309071</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116309071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575508.1">
        <property type="nucleotide sequence ID" value="XM_031719648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JD53"/>
    <dbReference type="GeneID" id="116309071"/>
    <dbReference type="KEGG" id="aten:116309071"/>
    <dbReference type="InParanoid" id="A0A6P8JD53"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF336">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="181"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="363"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="470"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="620"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="776"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="923"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575508.1"/>
        </source>
    </evidence>
    <sequence length="1041" mass="118161" checksum="45D142B2128F9227" modified="2020-12-02" version="1">MKNYFETPVVARWVEIMFKSYYGKPCMRFELYGSRGEVNKNVALFKPTEQSSSGSHHSSKAVDGILTATIGEGSCSTTQLENNPWWRVDLEHEYLIKSVSIKNNEDKCCYGRLSDLTVKISVNLKTNFTCASNISLTVAGEHKKVVCEQMRQGRYVEIVNSLRTVLTLCEVEVEAYVSAELRKDPVGLESGLVKNESITASSVLGDGYLPHHGRFNTIIGSGGWCALNNNPNTEYLQIDLEVRYTVKAVYTQGLASGCLPASAQVLTYSLSYSDNGINWAHVMQGSDTKVLPKGSYFFGTEILGRYFRFNPMTWKIHICMRVEMIGQRTYSSPLYRSIPNYALKESSWTTYTAQRSQLFSFGWRTFADKDQFLLINVVPGPKHVTGIVTMADIGGRSVKQYSLSYSYNGINWLDYMENGKVKVFSGVSVKYLSASHNLKRRVMALLLKILVLGVQIEVGLTVELYGCKVCDEQPLGMEDGSIQDSSITASSWKSGLEPYKGRFNGGTGWCANSRSAGEYMQVDFKRVMTISAITMQIVERTLLGWPYSFTLGYSYDGRVFRNYKTQDGKEKTFGFGSIQRPQLKFYLERFVEARKFRVYVKKFYNHLCMRFELHGYKKECFGPVELSLNDAKRLMKASSYLGLGFEPWYGDMRIGDDSLTWCAADTSTQQFLQFDLIFSHRITEISVSGRTADLDTFQQLNDSWVSRYRLQYREEMGDWKYYEYSGTIVEIQGNSGIKTAVSHAINTSLIARYIRILPVQWENWICIRVELRGCKVKDIALEMENGNTEILYDSILGDGTNFPALLGTPSNSWISQYATNPQGRPFLQIGFVTISKHITSFATAVVSDERTWSFYLSYTEEGHVWTNYTENGVLKIFEGNRNKHLVVKHNLRRSLTARAIRLNPITWRSKPAFKVELYGNEVCYEALGLESGLLPNSSFTSNAFIPGYEPWKARVNSPRPWCFISKTDRGLLYIDLLNLSDVTGIANQKDSYGYALEIKISYSLDNVLWRYYTGGNADNIPKVRGSKAEYFTLAEHRAVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JED5</accession>
    <name>A0A6P8JED5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308483</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574770.1">
        <property type="nucleotide sequence ID" value="XM_031718910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JED5"/>
    <dbReference type="GeneID" id="116308483"/>
    <dbReference type="KEGG" id="aten:116308483"/>
    <dbReference type="InParanoid" id="A0A6P8JED5"/>
    <dbReference type="OrthoDB" id="5966062at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574770.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50197" checksum="D4B66449E3B6F1AC" modified="2020-12-02" version="1">MDLFVPCTIDLHKHQSPDNKHGLEHINKLLEDELTQLRSLKSEKPKEFVLPTVKNMNKKNTVEGFEDYQRRAEQIRSRDPKAGDEEHPLRNMTSTIVPFSERFNDFSKDTRVLGKGQMPFFQLSSDGHSLSCRFPRLLETRTGKTSNHSLKELLDDVVSDDQRLNSKKSERCKQLSGKLVRSSLRVKQDSLGGDNSDHGELVNNLRIQNCSMTVRRDSYSQEVREKTKNPLPRSHRCNKKTFHLACTRDPKKCKTSDKDEGDCTFCAGPVFLHSRATQNGDGKSQRRRERKAQGGEKTSLPLLVKSSTETTKIVRDSCEKCKKRLEQAEVNRIALTMAGSSRKNTEVKNTDVERKTKSRPVTKEKVPEIPLASEKKETVLPLLECTAYMDQDGSLFLLPGAFTLRKKDYNIWSRYRKSSGENTFRSQAIMTGTTLPYLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GWM2</accession>
    <name>A0A6P8GWM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double-stranded RNA-specific adenosine deaminase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116286315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548654.1">
        <property type="nucleotide sequence ID" value="XM_031692794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GWM2"/>
    <dbReference type="FunCoup" id="A0A6P8GWM2">
        <property type="interactions" value="2246"/>
    </dbReference>
    <dbReference type="GeneID" id="116286315"/>
    <dbReference type="KEGG" id="aten:116286315"/>
    <dbReference type="InParanoid" id="A0A6P8GWM2"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19902">
        <property type="entry name" value="DSRM_DRADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19875">
        <property type="entry name" value="DSRM_EIF2AK2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF107">
        <property type="entry name" value="DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="233"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="321"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="421"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="4">
        <location>
            <begin position="551"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031548654.1"/>
        </source>
    </evidence>
    <sequence length="896" mass="99005" checksum="892677CCAE88EB32" modified="2020-12-02" version="1">MFGNFVNKNARAALKEYGDFNGVGVEYEMLDPTGPPHSPQYTARVMIGESRYDTATAATKKDAKEYAADLALRALTQEPGAYHSVYPGALSQAGQPSLSSGLSSSLPYRRYPKRLNRKKQSKNNQLSAPPDKDPVMLINEYGQKMNTTVKFEDTPCSFPGMFESFVFVGSQKFGPMRSTTKKMARKLAAIVGLKELINWEPKQGLYDAKPNAAVPELSVEPSAEGDGMTLTKDPVMLLNEYCQRSQKKIVFEEVQEGGTDHNRVFSYRVIIDDRTFEQGSGASKSRAKKNAALFALKSLYDMPLFMPEKQASEAMSASDSHPVSMLNEYGQKHKQKIDFEDLGYTGPDHGRTYSFRVIAGERIFDMGYGASKKEAKREAAKIALSELLGLDLEIDKMNQPPAEEDPSNAAKGPPKNPGTKSKVSELYEYCQAYHLEQPEPKDVFPADRTSPSFHYVSYKIGDKEFSIGDGRSKKAAREAAATLTLDELMKKNEGSKYTPVGTTEADRLAALSWNCLSKISKNAPDSWRFAGYKVLATIIMQDNDAEPCIVSLGTGNKCISGDQLCLDGSIVFDSHAEVIARRGLIRFFLCQLDILFANSGEKSIFEQPKAKGTKMKLRDGVKFHLYISTAPCGDAAIFVAGNTSPTINGMSEPIFGNKQHGLLRTKVEKGEGTIPLDSNDGVQTIDGIRRGQRLRTASCSDKLMKWNVLGMQGALLSNVIEPVYLSWLVVGDLFDAGHLSRALSARVERDGENTFSTKLPAPYHVNHPTLHCGRIASHDSSRKVETKNKAKNVTLNWILEDESKVEVFDACLGCNPAVKSPPRLSKLSLLNTFKEVLSKSPDVTLETVLVASSYREAKNMAQEYTKVKSLLFKLMNEKGYGSWELMKKPVELDQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYG6</accession>
    <name>A0A6P8GYG6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116286813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549259.1">
        <property type="nucleotide sequence ID" value="XM_031693399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GYG6"/>
    <dbReference type="GeneID" id="116286813"/>
    <dbReference type="KEGG" id="aten:116286813"/>
    <dbReference type="InParanoid" id="A0A6P8GYG6"/>
    <dbReference type="OrthoDB" id="10288663at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="579"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="920"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549259.1"/>
        </source>
    </evidence>
    <sequence length="1259" mass="142995" checksum="39DD0B7F577B33F7" modified="2020-12-02" version="1">MFKTECKGTYFCSKHLNPLELEKSSWSPCTIPCCVVCALKEQGVIYTIESNQENTARHSSDVVQGARETVELINESGTKTLACSKLQRRDTSNKDLGIINATFSSSRNYKKSEHFEKEKSLTDSSQNQEEAGKEDQSLTTSKIHAKKSSFFQPSIQDEEGLRFLGTVNETFHEIDSSEHNHTLEAYRKLHSTLPKRECQKVNSQIYNKNILEGLVLNDLPQLSTIEKFSSVLQSVMEGIENCSDLATNLTSDTHKNLAANPTEMSEDFVPASNDAMMASYSSFSFGEDYLGSSFKKLDDPEEKPVKIFDFAAEESERITEHPEEKEWRERRERDSKAEEKLQIDNDAKSSNNNTMKIGESKFERNFESPKEFNKMEPLGTPGNSGGSHRGSSSSKAEPHDVKESNARVHKQNGVRRNVSTKTDRGFKFFKRKIFSKSMKNSSTKNKSEGKGSPSLESFDGVKLTSKALEKEDGDKKVVSDAPSRITELENTIKQLENEKSNLEGEKLDLMNALSNIWIEMEDLKNSFDKDQGNVDIVKPLKEDKTTIVSFQEIGHDEDSSDVNKNKTSSFRKRHELCHQTQEEQSKVDLENQIRALNTKTSQSETLQSLRIKLSVINEDKENLSRKLNEMFEKNKVLEENLQKISGKTSPEVDKILEENLSFRSRLESLSRDKLLLEKNNQKLKIEKKKHKLMKLQIQKGCENLIHRINEVLQTTHAEKVNAIPLQLKSIPTSSKNNKSSFEKFSATSEMSSNVDKDGNSVEQIARKLERTNSIDSEVRTRKKIMKEFETSSRDGREERPPATVRRAETLNSKSFNSDFTDGKIKEMKVNRFPPTQSSRGDKPRKDLKSSSANEIGFRSTVPSDIQAPSLRSVTENEADPCLKFFEHLEAKCVLLLERFTVLNGKVEWLERNGDIYESMSPQGTYNANTQQSSPDEAASLDNVSTQNNQKDTVLLSCLSNLQKENDNLKLDNLQYESLFANMQNKRNENLSERMEDEVTTRRAEKDLHDLEIRVVPERDVELQENMVESDENTAYMRDNGEITTELNHSNNDFSDHQLKEEEDMSSWHRKHSKKESSKALHQNQIVPMKIRQATSLGQLPNLQDTLPKTEGDVYAKCGDTNTDRQAKGKPILRALSLGEGKTVSSRLAHQPTHPTNENLINTSPENSLQKHDQETIIAPDNVPNDDPVLNSQERCCQSFKLNGNHHENCSFILARLKKMTPVDEANTTAPPKTRENNKTLKKAMSTYGSRDWGYKVHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ80</accession>
    <name>A0A6P8GZ80_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC116286409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116286409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548818.1">
        <property type="nucleotide sequence ID" value="XM_031692958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286409"/>
    <dbReference type="KEGG" id="aten:116286409"/>
    <dbReference type="InParanoid" id="A0A6P8GZ80"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2732"/>
            <end position="2752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2941"/>
            <end position="2962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2982"/>
            <end position="3003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3053"/>
            <end position="3077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3097"/>
            <end position="3116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3182"/>
            <end position="3203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3431"/>
            <end position="3452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3473"/>
            <end position="3491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3518"/>
            <end position="3537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3558"/>
            <end position="3581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3619"/>
            <end position="3642"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="38"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="189"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="337"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="486"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="643"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="781"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="923"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1074"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="14">
        <location>
            <begin position="2778"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3017"/>
            <end position="3043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3032"/>
            <end position="3043"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="3281"/>
            <end position="3293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031548818.1"/>
        </source>
    </evidence>
    <sequence length="3780" mass="427896" checksum="D5EF6DB0EB3EC520" modified="2020-12-02" version="1">MVNLRTFTARYLAIQILTFSSRPCMKLEVYGCQAVSHCPKPLGMTSGKIANESLSASSYLGPDFFPWFARLDTKNAGGGWCAASNNISELIQVDLKDQHKLTKIILQGRGVEHVSESAWVNKFSLEYSMDGMKWTKHTENGTQEFEGNTNSDKREIAFTQPIMARFARILTLEWHNWTCLRFEFEGCNARTVPFGFETGEYQLENLISSNQYKENHTRLNQPNPDGLPLEIDAFSSVYSYLQIRIEPYGRVATAIALQGYDSKWISTYLISLSNDGKHFTYYMERGHPKIFEGNKDSQDVSRQSFFTEIRARFMRILPRTINNGYDFRMELYGYEVCSNPLGLQDGRIANDAITASSFNPGSEPWRVRHGTSGSWSPKSAVDSWLQVDVGRIVRLTAVAMAYDETLDKGVKAIRLASKKYIADKWFEYGIQGNDYKVFNCLPDCRLLTKTAIEGDSIIARYIRVIVVRYENHPYMKLELYGCEQVCMEDLGMEASFIKDVSITASSALNQQSLPSQARLNTNQGYGAWCANHTDASPYLQIDLRWLHEVRAISTQGQHSLYGDSWVQQYTMSYLKEPSNETWEKYMESKVAKVFVANDDSVTVVQNVLTSPITVRLLRIHPISWSGKACLRLEVYGCEVSRNDYIVPLGMTSMEIPDQNIIASSYNTSFEPWKARFQMDGWMAPQMPNQFLQIDLGMIDAEILAIGTRHPFQKDRRVLEFFLSFSDEGLFWYQYMEYSKPKRFHNEIHPYKGVQKHFLSQPIKTRYLKFEVARWKLINSFTVSLELYGKKGVPISKFNAVTYSASSYIYSNPPRAAVLGGSSAWCAEYVDNRQFLQLDLGKSFPITGVETANVSILETMNTFIVSSSIYGNIWDDYKEKQTVKLFNVNLRELFTKAILARFVRFNPKNWTKTLCMRAGILSKAITAPLGMSKWRIANSQITATSHAGPGTEPWRARLNSDDLSDAWCAGEDVIGQYLNIDLLYEHSVTHIALQGRFATASEAWVIDYQLLYSMDNIVWNYYVNASYVKILKGNVDSFAVVKVAIDPHIRCRYIRIQPTTWHGRMCLKTEIYGHSILGPIGVNNGDVPDTYISASTYKPNREPWKARLNRNDNNNSIGWEPLTIDLAPFLEIKGIHQMRVIGVSTQGIHSATYPAFVTNYTLKTSLDGLNWIDYVEDGIQKIFNGNNDTFSVVTNILKSEITVKSVRIVPVNWTNGVSLRVELFGLSVLPRDGHYTLYSNWSACSATCGPGFQYRTRNCSNPEPLYGGKNCTRLGSDTQTRLCNAPLCPAPFYAAPPIFKKDQPTTVMIQNCTALDLTIDFGDGTKLQTTNCSIEHTYIIGGIIEIVISTPNHEVTRNAHYVEDSIKDFQEHNTTKAILLGRNFTINWRIDGGTILQLGFNYGDGSYQNSTLVTRDGFQTGVALHQYNIPGVFPIELIVSNLINTSVINLNVIVELAVNVSLTLSTKTIFDRTYEFDDVILQIEVLNGSNPHFVINTDDGTPLVNQTSTTLIHKYRAAALRTPNIVAYNNVSSYSSGCNITINKMDLIVNASLEVHDTIYPNSTFVNLTVLLGNPFLCLINLGDGTLINRTSLDNSTQFDHNYIVGEYTITINCSNHLSYQLLSEKIKVQSAIQKASLAPTAPVVVNHTHTFVITAEDKGSNSCYVVRPGDGSTYGIGKPHCLINHPSVTFLDMQIPFLIKHTYGAIGLYMVTVSGSNAISSVHLEDRAVVVQGRCSYPNISLLNIGNNKQDPTRITRIQSLLVYTKIYIDCDPTTLYNVDWNISLASNNSIGLSYKTFETLTIYQRTLDYGLYQVILNVSMRGLDGVYQFKHGFIEVTANDFIPMILGGHFVRRGLNKSIYFDASETYDPDFTTGEDAFEFYWSCSNGFLPSIERIKAMSSFNRSGLPVFNESGFCRSNTNFYKGRSKINYTTSFMSIGDNYSVAVDVFKDVKGMIRHARFVQIMSLVDGNVPNLYLRCLRNCMALVNPNNKLHLEVFSPDLTDTASYHWRLFREVTSNGTSKWMEIEELRNLTKTELNNRFVVIAPNVIATEERYKLQGTAWMSGGPRGLAEYIYSYNMPPYGGSCDVDIPKGNAGDTLFTFKCSDWMDHHLPLTYQLYYQTNFGVELLLYHSVFPSFAIPLPLGEASNNYTLNMTMRIVDSLGAYNTTLLNTMVVRNESSNMTALLLGYLNFVDGTELRDLMNKGNLLDASIRFMSMLSVLNSMEGDQGHLSLRIQIRTKIAKILSQWESRGLLNVQILASALSQAIALREEVSVATQRHCLNSLSDMSDFIIDQSRDRSVSETTVADTIQILFYGLSNTISASSDSAKVPYIPGLKDINITLPNSNLTLGETSRPSDIRLEAVQISKDTIAKIDDLAKESLNRLASGEEPFKIDVPILSMSLQRINADDIDNMFFNVGKASVRFPNSYTLFGASHGMDQVGVKSMRMKRNVFTWNLNWLRVKTELLLVELKDPVQETLSVSQISQPIHLIIPRAASLFPPPETSFISKERQSLAFHQFNITSLKPMNIRILPVEGKVSFGIYWKYAMRPELNSEDFVGRLPDFSSCKSKGTSYTDCEKDPYTIFIDTTRLDQLGKYFLGVQTLDDYPVNKKERVRRSACEGSGRSKRSCLEYKTPPPSPSPNMGGPIQYDPRFHFNYTIQRFYSPCLFWDAQNDTWSEQGCSTGNFSTYQHVHCKCTHLTSFGGDLLVAPNPIDFDKVFAGFANISDNMAVLGVIITAFSIYTILAVWLRRLDKRDAARGGISVIKSTIDSTEDHPYEVIVQTGSWSNSGTSSNVFLTVIGEEGESAAIHLTDKYKSLFNRGGTDEFIVLLPKDIGKIHFLRIWHDMTGPSSSWYLNYIIVRNIKTGAQFNFVSDQWFALEKEDGAIDRVLRVSAKEEMTNFKTLFRQKTEKDICDGHLWISVMAKPPKSTFTRVQRLSCCMSLLFTSMITNAMFYNIGNEPDTSSITLGPITISIKQIIIGIQSSFIALPINIIILQIFQKAKAKENTMTPNYKQPYSTWQDEGDAQSNKRKDGSSNAEKKGLPHWTVYIAWTLCVLATVVSAAFTLFYSMMWGKETSNKWISSMLVSFFQDAFVTQPLKIFLLALFIATFLKKIPQEFTKKDTKEQELDSLQVQEPGNSIFNEDMMASIASRCQPPNEDLVRRARDYKMKELRMHGIIKENIFFAVFLLALLGVSYSIRDYESFRQTSNIKAMFTEQVNDNVTLWTFVENTVLKFSFSRQWYNGRADGAEGFTEEKKYYMVGMPRLRQVRVKKENCTLTIVKSITTHCVGEYSIPNEDTSYYLPGWKEPGNLTSEACPIPWRYQTSWELDGIPLWGHKAVYNGGGFTADLGYEMWQAADVASTLKKYNWVDELSRAVVVEFTIFDPHVNLFSMVTYVVEITGTGSGSSFVKVDTFKLYLHLGPSKMLLIFCEVLSIIICLILTFYTCKKIKTEGLKYFRNKWNLLESAQLGLCYAAVGLFIVRLTFTAKAIQKLQENPFLFVSFQYIAKWHEVNVYVIGIIVFIATMKFLRLMKFNRHIAILSRTISNCLKDVAIIGFQALLVFTAFSIFAYVTFGTKMEDFSTYILALQSQLTMMLGKGYFTDLSQVDPVLGPVYFTLYIFAMMFFLLNMFIAVIADSYAEECTGVDPDSEEFVMAGFMMDRLRSLFSKEKQTTEPWVEIKCPEYKDWPGTKQEALFEKARQSHEMLKIKEKQLDYIMQGLLHAEKNIAKSEESIAWKTMAILPSRDSKKYNKVALMILLTEEYIDENEEEADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H046</accession>
    <name>A0A6P8H046_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Octopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116287268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549794.1">
        <property type="nucleotide sequence ID" value="XM_031693934.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H046">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="GeneID" id="116287268"/>
    <dbReference type="KEGG" id="aten:116287268"/>
    <dbReference type="InParanoid" id="A0A6P8H046"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000368">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031549794.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37887" checksum="A19FF62A8BB8229A" modified="2020-12-02" version="1">MSQLYTNNTPAQVAVAVSLSILTVANVIGNILVILIILTNKSMKLPMNYLLVNLAVADIMVGIFLAPQYVFISFFXHPDGVAGKILCKVLTGGSFAWIGAVASSFTLVSVXCERYFXIVHPYSIKLKLNMKRLKLIVIFCWPYALLFNFPTLWTLDFSTEVQSCTQQWSMHLMWLSTTYSTLWLVFVGVIPISIMFVLYSRVIYSLWFKQHQVQGTQLALLKSRKRVTKMMIIVSVVYVVCWLPNILIYLFSSHDTGLVLASLPYVASLVLAACNSAINPFVYTLQSERFRRLLMGLLRLRKQRQNCIAVVNQGKSSIKKCNISGPELVDTKKNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H078</accession>
    <name>A0A6P8H078_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116287298 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116287298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549824.1">
        <property type="nucleotide sequence ID" value="XM_031693964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H078"/>
    <dbReference type="GeneID" id="116287298"/>
    <dbReference type="KEGG" id="aten:116287298"/>
    <dbReference type="InParanoid" id="A0A6P8H078"/>
    <dbReference type="OrthoDB" id="5953342at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027893933" evidence="3">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031549824.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23496" checksum="08298A73E6889A99" modified="2020-12-02" version="1">MKLLILALCFCLAVAENSNSIEDLEKILSSDSQLPDIGNLENVDKLEALMQNKLKLKGKFEGYKYCMDGKTLAEGPGMEGCPKRLCYDKKTLQCRKELGKLSAKERFHLCHTEYITYRERCPYTCGLCKPRNPVQECRKIHGATARCCSNGKPALKPDKSDCEVCSNNNPSLCERFYKFLGGKCETSAYLVRRYLYTNCPKRCGRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0E6</accession>
    <name>A0A6P8H0E6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 134-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549899.1">
        <property type="nucleotide sequence ID" value="XM_031694039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0E6"/>
    <dbReference type="FunCoup" id="A0A6P8H0E6">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="GeneID" id="116287365"/>
    <dbReference type="KEGG" id="aten:116287365"/>
    <dbReference type="InParanoid" id="A0A6P8H0E6"/>
    <dbReference type="OrthoDB" id="5854099at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026321">
        <property type="entry name" value="CC134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15002">
        <property type="entry name" value="ERK-JNK_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028311659" evidence="3">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549899.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27917" checksum="9ED389865A3743D0" modified="2020-12-02" version="1">MNQILQKYLIIFLFSISHANEKIDKIEDELREEQRLLRENQARLQLETYRRGFKVKRGYQVAASKSMQLEVKGYAKQYEMTDKVLEKMFMVLKDSKTALIESGYTPGDPFPTDKKIQEALAHVLENTAFFGDILLRLPDITHQIYSKSKENQLIMKWCISICNASEVYDKTGHQLLDLIAQELELIPKDENYINPYKESTMLEKEFAKQKAEGKGHTPQQKKKEKKKKKKRGPKLSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2A5</accession>
    <name>A0A6P8H2A5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550519.1">
        <property type="nucleotide sequence ID" value="XM_031694659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287951"/>
    <dbReference type="KEGG" id="aten:116287951"/>
    <dbReference type="InParanoid" id="A0A6P8H2A5"/>
    <dbReference type="OrthoDB" id="5980461at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="61"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550519.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="50485" checksum="2D8C4F00B5F57E88" modified="2020-12-02" version="1">MAPPKEDGKKETIQFIDPVTSVSKSDELRAHLQKMSLKGDTEEPVPISFEDICAAAFRICKGVAKTPCEKASISNSEVADMDIFFKKEYLHPTGSFKERGALNTLLLLSEEQKRRGVIAASAGNHALALAYHGHALQIPVTVVMPENAPIVKQTMCRSYGANILLQGHNLYESKENALLMAREKGLVYINGYDHPHIISGQGTIGLEIIDQVYPLDAIIIPVGGGGMLAGIAKAVKTVYPHVKIIAVESERCPSFKAAMEAGKPVKVDAHHSETLADGLCVPQVGTSAFANSKDLVDKIITVSEDYIGLAILYLIEMEKAVVEGAGATGFAAVLSGQLPELSGKRVVIXLCGGNIDPAVVGRCIDRGLATDGRLVRFIVTVSDRPGGIDRLVNVLASSGASIKDMFHERAWLKSSAFKVQCKVVAEVRDRDHASMLRTLLEKMYDDVHWNTDHSSAYTNDPPYTVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2R8</accession>
    <name>A0A6P8H2R8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras association domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549893.1">
        <property type="nucleotide sequence ID" value="XM_031694033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2R8"/>
    <dbReference type="FunCoup" id="A0A6P8H2R8">
        <property type="interactions" value="1366"/>
    </dbReference>
    <dbReference type="GeneID" id="116287360"/>
    <dbReference type="KEGG" id="aten:116287360"/>
    <dbReference type="InParanoid" id="A0A6P8H2R8"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20885">
        <property type="entry name" value="C1_RASSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01778">
        <property type="entry name" value="RA_RASSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21885">
        <property type="entry name" value="SARAH_RASSF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF10">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="305"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="9">
        <location>
            <begin position="394"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549893.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="53646" checksum="FFC41143A9BACE80" modified="2020-12-02" version="1">MSTPIRRGFEFLLEGFLSNWGPYLWELLLFCLEKTAFGGLYLLGIVMDDDVFLDAPNSSAINGAHSNPSSPNEKIEMRTLDGDMVRSLSVPDVSHDQRVMDKSKAAQPSIIHFFANFVNRKAVKKRDTDEKANNVNVRHKIGRGHGFVPFQLRNPTWCDFCGEFIWGFYKQCVRCKKCKYTCHWRCHGEIDLDCIGAWPQIERNMSIDEVSMKTLHLLEQSDQKRNEPYLMISTNISHGSLRRKIGEFNTQTTGLIMTMKDETIFQGFVRVHMNLLRPVNVVAGERPLSILENVGNSVDSKRSRTSFFLPLGTVKALHVKSDTTVQEVIEALLKKYKIADNPRKFALFESYQEQDNHVILRRMSDVEKPLMLRLLWGGADIKHSFSLQENETGDIVWEVFSTPELENFVKILEKEEEEHIAMVREKYRIFKEKLQQEMKELGILVPTDEKATSKSTNNKDDSTESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2S3</accession>
    <name>A0A6P8H2S3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288098</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550694.1">
        <property type="nucleotide sequence ID" value="XM_031694834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2S3"/>
    <dbReference type="GeneID" id="116288098"/>
    <dbReference type="KEGG" id="aten:116288098"/>
    <dbReference type="InParanoid" id="A0A6P8H2S3"/>
    <dbReference type="OrthoDB" id="5988979at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550694.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14828" checksum="182DDF884BD3875C" modified="2020-12-02" version="1">MYRELLTFIALICINVLGFRVTGVAIGNPRRSSYWDPSRFVPLSHLMPGGQGVTYLSDLTQNLADDMSSQIALGGQQVSAVGQAIENHEDAKSEEIQHVSDIVDSNYKSTAVDNEEEEQEINEGDGYEENEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3F4</accession>
    <name>A0A6P8H3F4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031550889.1">
        <property type="nucleotide sequence ID" value="XM_031695029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3F4"/>
    <dbReference type="FunCoup" id="A0A6P8H3F4">
        <property type="interactions" value="1246"/>
    </dbReference>
    <dbReference type="GeneID" id="116288257"/>
    <dbReference type="KEGG" id="aten:116288257"/>
    <dbReference type="InParanoid" id="A0A6P8H3F4"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="51"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="308"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550889.1"/>
        </source>
    </evidence>
    <sequence length="565" mass="62002" checksum="46AC15DC58B23E7F" modified="2020-12-02" version="1">MRGLAVFLRYNRCLNRFYLRSSWYHNLAKASVVQSQVDKNSPDFKTNKENMERVVEDLRAKVNKIKEGGSKSARERQTARGKMLPRERIANLLDPGSPFLELSQFAGYQLYGKEEVPAGGIITGIGSVNGVECMVVANDPTVKGGSYYPITVKKHVRAQEIAAENRLPCIYLVDSGGANLPRQADVFPDKMHFGRIFYNQAQMSSKGIAQIAVVLGSCTAGGAYVPAMADESIIVKQQGTIFLGGPPLVKAATQEVVSAEELGGADLHCRTSGVTDYYAVNDLHALHEARNCVKNLNYKKNPQVTIEPPEDPLYDADDIYGIVGTDLKRSYDIREVIARIVDGSKFDEFKALYGDTLVTGFARIHGYPVGIIGNNGVLFSESALKGTHFIELCCKRNIPLLFLQNITGFMVGKEYEKGGIAKNGAKMVNAVSCAQVPKITVIIGGSFGAGNYGMCGRAYGPRFLYMWPNSRISVMGGEQAATVLTTVSRDQREREGKTFSKEEEDAIKIPVMERYELEGHPYFSSSRLWDDGVIDPADTRTVLGLSLSAALNAPIKHTNFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3Q6</accession>
    <name>A0A6P8H3Q6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550213.1">
        <property type="nucleotide sequence ID" value="XM_031694353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3Q6"/>
    <dbReference type="GeneID" id="116287668"/>
    <dbReference type="KEGG" id="aten:116287668"/>
    <dbReference type="InParanoid" id="A0A6P8H3Q6"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF39">
        <property type="entry name" value="E2F TRANSCRIPTION FACTOR CC-MB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550213.1"/>
        </source>
    </evidence>
    <sequence length="786" mass="89631" checksum="06E110D75E4DC776" modified="2020-12-02" version="1">MFQLTRLKRFFLVCNAFVFAIAFLYSVSHTLKFNYSGFSDMYPCHYSKLTPPENGTNELPSACKPYTPDKSACETINKHFRSPRDPIETQTCPTKQYQDICWFKNDTKLECSSKVCGGETVSLGRRDLKEGHITTWNPITPFNTDKVWSFVQATLKEGDTFCFMKCGSILQVLVFPPQLFLKKKDTKDKRKININVVVLDSVSRAHFYRMMNKSINAFKDLVYSEDIPATALDFEFFQSVGTNTFENIRTFFSGFFVGKDADGKKQVEQPNVGMDVMYGHFQKQGYQTIFQDDLCWYDSWGTLLNDIKISGTSSPTAERWAQYKEKAGKNNIDHFGNTYFSCQVLQQYGKTNPFGDPEKVCLNGRFYGSYFLRYVERFASGVRTTDNAAPFVSYLHINTGHSETSKRISNIDGELADFIYKMARDPLTWTIFFGDHGHRRTAFALSTTSGIYERYHPLSFMIVPNRVAEILGKNIMDALTINQNRLVTVLDFHRAIMSINDQNRRNSKNPDESGVFAEISPSRTCSDVPLMPLVKCQCIESEQKYDDNSPKIQWIAEFALGKLNNDIQNQYSEGAEGKKVNGYGNCRRYIGTSFRNIIHTKSGALTRFNLHVKANGLEQEEVFEVEVATEERRAVLKSFERISTYNIFEDCVDKSVNIKLCACDRNKTKNGYTNPTHVLTIQEMKSLAKTAMFGREPQIKTLHGDCLFQITRNYNDAVTIVVEVANACKKKTFKVEVTGDIHNIFLSRSLPMSNVVPPNTYTFIYVSTKQSVTHFKLEISISASIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H452</accession>
    <name>A0A6P8H452_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall protein DAN4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550338.1">
        <property type="nucleotide sequence ID" value="XM_031694478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H452"/>
    <dbReference type="GeneID" id="116287783"/>
    <dbReference type="KEGG" id="aten:116287783"/>
    <dbReference type="InParanoid" id="A0A6P8H452"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550338.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="55772" checksum="6014F6CC11EADD0A" modified="2020-12-02" version="1">MIHLCTDNFQCSCYTFDGRPKSWSYGRQQCRTQGGDLVSMETVEEWELINTQIQNRTAGNFDEWWIGLEKRDGRWVWLSNHTLTYNKWQPHEPSNRTNEKCSVMAKNYPANKYGLFGDTRCDLWRGWICEYKIKVTANCNETQVSRCSDETTPVTSITESTTTPDQKTKLTSESISTTVIQPTSKTTMTYPNVKASSTKTMTDKERIATSKYSIPTTPYQKDTKMPTTTETDKGTTATDVSLTTKKPLPTLTIIIAILVVVLVVFLCCVVLCVYGWNLKRKGKPKTRVKHDETNTEHNTSDVMAGSSSGLQVSEHELKVIVIQPNNACAQKDSHATTHGNALDKSNATKEVTSCLVSHIIHDALEMRKHNNMTSLESTGKDSSQNKDKADHSNPTDKSPQEESDLPPDDTVDKENTKVPDICATVGKSKKKSKITEVVYAEVNKSIKNTADQRQDLVTYAELAEFNHDATQSVPKVPPPYQPTEYASVSNITVRSQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4S3</accession>
    <name>A0A6P8H4S3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: WW domain-binding protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551349.1">
        <property type="nucleotide sequence ID" value="XM_031695489.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288662"/>
    <dbReference type="KEGG" id="aten:116288662"/>
    <dbReference type="InParanoid" id="A0A6P8H4S3"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551349.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40849" checksum="4E6DCF9F838A75D9" modified="2020-12-02" version="1">MTEYWQSQAKKFCDFCKCWITDNKPSIEFHERGKKHKENVARKIKEVRPFSIAASNQIYNSQEVPNKNLVYLPLHVXVHKRGAQTLKDNEELKRNLQAIEDAALEAYKKDIGEEAFNRATQKTTSTSRPVSYQQKTYQEGNTTTTHNETSSAGCTIVYNDGQPVAHCSHHWSIAQSPEGYYYYYNSETLASQWDVPDCLQTPDNDTSDETPKQDETQVQASTTEQKEGKEEKWPEVKQSEDTQPEQKSNKDIEDKVKNTKVKSSSPYGAWTTVQIIEPPLNLSKNTDNDDKMNDSEETDETEDPEVTARKTESKFKQRQTPKITFHQPDDQVIAFKKRKLNSEKKRNIRQTKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6D7</accession>
    <name>A0A6P8H6D7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oncoprotein-induced transcript 3 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551056.1">
        <property type="nucleotide sequence ID" value="XM_031695196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6D7"/>
    <dbReference type="GeneID" id="116288410"/>
    <dbReference type="KEGG" id="aten:116288410"/>
    <dbReference type="InParanoid" id="A0A6P8H6D7"/>
    <dbReference type="OrthoDB" id="5944918at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36191">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36191:SF4">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027954420" evidence="4">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="UMOD/GP2/OIT3-like D8C" evidence="5">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031551056.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26918" checksum="2359BCE51E9401C3" modified="2020-12-02" version="1">MKIYLIAALFLGALVVAHSFEEDEKVELPEVPEQEEQSDEEVNTLPGTEEDTQESRDEEVEDEQQDPEKRAFPKNVLSYYSCFQIKRRGYCGHLFLRNLCAATCYRFHPNDPCRKYAVLNQLNRRQSRPRGNARPICDQKGFATRWYRFTGLAGRGMPTSAPPKNRCGTHAPGWMVGRYPAFGQTVTRKVCYHWGKNRCQWNNFIKVKNCVGYYVFYLRPTPVCHLRYCGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7C6</accession>
    <name>A0A6P8H7C6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane channel-like protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116289472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552309.1">
        <property type="nucleotide sequence ID" value="XM_031696449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7C6"/>
    <dbReference type="FunCoup" id="A0A6P8H7C6">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="GeneID" id="116289472"/>
    <dbReference type="KEGG" id="aten:116289472"/>
    <dbReference type="InParanoid" id="A0A6P8H7C6"/>
    <dbReference type="OrthoDB" id="1936208at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF24">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="505"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552309.1"/>
        </source>
    </evidence>
    <sequence length="758" mass="87004" checksum="D22E7D90E3A281CF" modified="2020-12-02" version="1">MEAVEIEMVPLDEDEPPALPPKASSLMQELPSRMARHTTMSGITNSRRRGTLAIGATSALKRRAGRKMKSRALRRNQEMDTLNAIFDVHQPNIDDFDEDLLESVDFKAVPLPMAQRKRFRDSMKLHGMADVSRWKIFKNKMISNWKRFRSAGREILYSLGLWRGHLKEVEGQFGSGVVSYFSFLRWLVFLNLFIFLLEFGFVVIPTVAICSSDPPVNSTFNFTGCTYVKPKVVSNVTQTTNTANDILNFFIGEGWMRSTLIFYSNYPSELLISAEGFRYDLPLAYLLAGGAYFVFGFFLMITNLMSNLKESYIESEGVFNSYSNKVFAAWDYCIAENKSAEHRHKIIAQQIHYDISEQERKKRILLRTTKEKIALYTARILINLIVVPAVWYATFYVVFRAILFQETESTEKGNKSEVEQMLVRYGYDLLIALAITLPNLVLPLFFEFLAIFEDWSPDTELALDLLRRVFVKLPPLAVLMFLQYFKISEKVKKLKGHGKPACESCWENDISSQMYMLVWVDFVVVVITTLGVETLRKILFHRFRCFKKIGMQQFDIPRNVLDLVYGQCLILIGTFFSPLLPAMGVIKLAVLFYVKKVSLMYNNTLPERSYQGAKSNFTFTLLLLFGFFMCTAIVGWAVTNVPPSTCGPFNNVACDVSTSIFDKLSFEISSWPLLIDQAVYYMSTAAFILPVLIIFMVCLHYYWSVAKSHRRVIRLLKDHLAYEAKFRRALMMKLEQSNTERHDSAEHGVSEVTLEIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7T5</accession>
    <name>A0A6P8H7T5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CUSTOS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116289677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUSTOS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552489.1">
        <property type="nucleotide sequence ID" value="XM_031696629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7T5"/>
    <dbReference type="GeneID" id="116289677"/>
    <dbReference type="KEGG" id="aten:116289677"/>
    <dbReference type="InParanoid" id="A0A6P8H7T5"/>
    <dbReference type="OrthoDB" id="5986465at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026694">
        <property type="entry name" value="CUSTOS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14482">
        <property type="entry name" value="CHROMOSOME 12 ORF 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14482:SF0">
        <property type="entry name" value="PROTEIN CUSTOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23999">
        <property type="entry name" value="CUSTOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552489.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24682" checksum="405697EF954E06C6" modified="2020-12-02" version="1">MASSSSEEDEEERKIMAEIAGCAAKDLTEAHLVIKQMERENIKKSGRNEKDCDEETQSSNLTPEIKRHIAKKLSSYLDGCIQIETGCTFKQKKIMSQVSGIHLFCLSKNKLLDVENDYLKEKQPKTPKRSHQSSSSSESSDNEEDLTRFQEATVCGQSIIDNSCPSIDNGVHRENSNKKKKKKKKKKDQNKVKNKNVSEYEFDNLKDRWKEKYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H892</accession>
    <name>A0A6P8H892_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551721.1">
        <property type="nucleotide sequence ID" value="XM_031695861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H892"/>
    <dbReference type="GeneID" id="116288988"/>
    <dbReference type="KEGG" id="aten:116288988"/>
    <dbReference type="InParanoid" id="A0A6P8H892"/>
    <dbReference type="OrthoDB" id="5979997at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027700333" evidence="2">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551721.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="59341" checksum="66CBCCEA9469F1B6" modified="2020-12-02" version="1">MITVIVSAIAYLVESCTGVVLEEQLENTSIQEFESLCVWDASAQLEDFTKFDPKDAIFQEFDPPRQLEDDPQAWKKSLPTFLKSFWECLKTVLLIQTVAGCLIGLFAVGIYFFNLLTLEWCNEETPHWNKMPIQVQRLRVTTAAIEGIFVQMWDFFCIILIFPLSLIKDLHLLTLNLLAGFIELAYRLFLQLYGIYKISWMAYPLNALFCIVVLINNFLLARHFSPHSLGRAIRIDFILSAQFLLGMPVTFFILYELFPLYVSQEERIKIVIAGMSPFASVIPKVICRLGAQSLNGIIHPGTAHVLVTVIYGASAVVFRVLQAELTSINKFIACGIAHAFIDLLERITITMRDNIWGYLYRLVRRQTSRQPKYISPRSRRLIADISIQIMMQEATALITTLGFINVFQYVYSTSKPFTDYELVFSFFIRVGLGLSIDLVFNVISLLIQTRVMNIAVNRVWKKKWRYHLLVNTVLLFVSVLYFSDHLFGIVKSALKEGYITNMNDRQTPLSRPSASIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8X0</accession>
    <name>A0A6P8H8X0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC116286487</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17 18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031548870.1">
        <property type="nucleotide sequence ID" value="XM_031693010.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031548871.1">
        <property type="nucleotide sequence ID" value="XM_031693011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8X0"/>
    <dbReference type="GeneID" id="116286487"/>
    <dbReference type="KEGG" id="aten:116286487"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="109"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031548870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031548871.1"/>
        </source>
    </evidence>
    <sequence length="693" mass="78373" checksum="AB78C8779AC2B710" modified="2020-12-02" version="1">MDIVSLTGFDTLVLITTIATILALFFAYLYWSKKLGYTGDYKQRKRPRCNLSEQSVEVKDSGGARRSALTDQIIARFYDDVDTVYNGFLRGVRLSGGDPCLGERHPLLHKYEWLTYNEVHSRAYHVGCGLVSIGCQPSQNTYIGIYAPNCVEWVLTDLGCQMFSMISVPLFATHGPDACRHIIKEANLQTVICHESKVEFVLRSRDEISVVRRIVKIGSDITQHEKSLAEKWNIKLIAFKQLQDIGKTTPLERNVPKTDDVLTVCYTSGTTGTPKGAMLTHDNVISDLAGFKFLLKQFDKEVTKDDVLLSFMPLAHMYERMNQVILMMSGGRIGFFSGDPKRLLDDLKELKPTVFPAVPRLLNRIHDKVINEINKSKVKSWLFEKAMMAKKKDLERMVLRKDTIWDLLVFKKIQDLLGGRVWLIISGSAPLSSKVTTFLRCVMGCHVQEGYGQTEATASSVLQLLDDFSSGHVGAPNPVNHVKLIDVPEMDYYAKDNQGEICLKGRNVFKGYLNNPEKTAEVLDEDGWLKTGDIGEWTESGTLKIIDRKKNILKLSQGEYIAPVKIENIYMRSPFLAQVFVHGDSLRSYLVAIGVPDEEVLEAWARKQGIMGRFRELCKNKRVLDAVFKSVTDIGKECNLNSLEQIKGIYLHDEPFSIENNLLTPTLKKKRPPLVKLFRKQIDALYESIDNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H941</accession>
    <name>A0A6P8H941_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116286828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549272.1">
        <property type="nucleotide sequence ID" value="XM_031693412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H941"/>
    <dbReference type="GeneID" id="116286828"/>
    <dbReference type="KEGG" id="aten:116286828"/>
    <dbReference type="InParanoid" id="A0A6P8H941"/>
    <dbReference type="OrthoDB" id="5989160at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028403876" evidence="2">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549272.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17400" checksum="D4877655F480CFA8" modified="2020-12-02" version="1">MNQGLQRWITFLGLMAVSLITEASLGEWGEWSVCSRSCGGGTQTRNRTCAGCVETRTCNEDRTCRIGTTAMIGVAVGVSISISTIIIVVLVGIFFVKEKNEKKRARSTYKSSLVESTPGVSRRTRTCTVDSNLDIKLNVIRQDNDSQAQRSRVCLVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H992</accession>
    <name>A0A6P8H992_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116286602</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116286602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549015.1">
        <property type="nucleotide sequence ID" value="XM_031693155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286602"/>
    <dbReference type="KEGG" id="aten:116286602"/>
    <dbReference type="InParanoid" id="A0A6P8H992"/>
    <dbReference type="OrthoDB" id="5947805at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031549015.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26340" checksum="983D9F14B09DFA2E" modified="2020-12-02" version="1">MAGVRALHISNGYHNPLTNTIKLQQTLRGIERKHFSLVKQKLPITFDLLCKMYIFIDLANPDDTVYWSAMTIPHFQLLRASEFMSTDSSDPMLTISDVNITTTANNDEYLXLHVKTSKTDQKRQGVTLYTGHAKHXVCAVCAMKSNLHLQRLRSQDRSDGPLFGLSSGSTLARLNMANYLAVLLRLLGIDSGSYSRITFGSVAPHQQRLPDSKTTRLSSWEDGTPIVINVIFVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAJ7</accession>
    <name>A0A6P8HAJ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histamine N-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116287043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549515.1">
        <property type="nucleotide sequence ID" value="XM_031693655.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HAJ7">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="GeneID" id="116287043"/>
    <dbReference type="KEGG" id="aten:116287043"/>
    <dbReference type="InParanoid" id="A0A6P8HAJ7"/>
    <dbReference type="OrthoDB" id="5956379at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031549515.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36427" checksum="91EC7927F9E886D3" modified="2020-12-02" version="1">MDSFAINTEERYAESFKIFRQISEEIPQLVNMLNVCLGDILSKLNFSPQDSYQLNVLSVGGGSGEVDIEILKLLNKKMVQESKGCQIKIDNWVVEPNKYFLDIYEAAIEQLPXSWLKEEEGAEPEQRPKNEGSGEVLFKLLNITFDQFMETNVDKKFHIIHFVHSPYYIDMEQALVHCMGKILHQNGCVICVVEEDGIVETVVNKLNKVGQSDNATKCKEKNIAERIKKIAENHHWKFENHIDKYKFDISDVFDEQSKTGNLLLDFFTHVVDFRLTNDQVTVQETLDHIRSLALVEXGKHFGSAVERIMFIYNHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBS8</accession>
    <name>A0A6P8HBS8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553869.1">
        <property type="nucleotide sequence ID" value="XM_031698009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBS8"/>
    <dbReference type="FunCoup" id="A0A6P8HBS8">
        <property type="interactions" value="2198"/>
    </dbReference>
    <dbReference type="GeneID" id="116290890"/>
    <dbReference type="KEGG" id="aten:116290890"/>
    <dbReference type="InParanoid" id="A0A6P8HBS8"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000141">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553869.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39033" checksum="B8BA2FF5269AB66F" modified="2020-12-02" version="1">MAAGPIAERNQDATIYVGGLDEKVSETLLWECFLQAGPVVNVHMPKDRITQQHQGYGFVEFLGEEDADYAIKVMNMIKMFGKPIRVNKASAHNKNLDVGANLFIGNLDPEVDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGFAFINFASFEAADAAIEAMNGQYLCNRPITVSFAFKKDSKGERHGSAAERLLAAQNPLTQADRPHQLFADAPPTTVPNVPPMSVATMPPMGMGMPMGMPGPPPMGMPPVPSSMPPPGMPPPGMMPPPGFPGFHMQPGMMPAHGMPQFDPMQHQHMQHQPPPPPSNMQGGMPMHMQMMGQPPPPPPDMNHPHGMQFIPMPPPMGQNIHQPPPPPQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC00</accession>
    <name>A0A6P8HC00_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC116289861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7 8 9" type="primary">LOC116289861</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552651.1">
        <property type="nucleotide sequence ID" value="XM_031696791.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552652.1">
        <property type="nucleotide sequence ID" value="XM_031696792.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552653.1">
        <property type="nucleotide sequence ID" value="XM_031696793.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552654.1">
        <property type="nucleotide sequence ID" value="XM_031696794.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552655.1">
        <property type="nucleotide sequence ID" value="XM_031696795.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552657.1">
        <property type="nucleotide sequence ID" value="XM_031696797.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552658.1">
        <property type="nucleotide sequence ID" value="XM_031696798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC00"/>
    <dbReference type="GeneID" id="116289861"/>
    <dbReference type="KEGG" id="aten:116289861"/>
    <dbReference type="OrthoDB" id="5995821at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031552654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031552655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552658.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30424" checksum="0ACCDADBDEBFC654" modified="2020-12-02" version="1">MHNASVATTPTMKKLVTQKNGEKEATTVSKTISSSTKNVTSSKVVTKTTSITKTSGKKVQQFKTSESSKLFSDESWSSAIHEGTFGSTLQQQKTLKFESSSEKQELTDFKKSDIHFDDQRALHLKQGARPKTTSSSLMRSPGINTKLESSFELHPDIHIPTSLRHPSPTAFKIKEPVWQEGFSLFPEYFPDVCSAQSMRERFQRSVNDAVPVPVKETKLLSCSTKQYSWEKLDGDEESEAQKIANSWLQIFGENEPRKANKDIDRKAIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC86</accession>
    <name>A0A6P8HC86_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116290368</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553246.1">
        <property type="nucleotide sequence ID" value="XM_031697386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC86"/>
    <dbReference type="GeneID" id="116290368"/>
    <dbReference type="KEGG" id="aten:116290368"/>
    <dbReference type="InParanoid" id="A0A6P8HC86"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027685160" evidence="6">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553246.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14105" checksum="1272F7011E402827" modified="2020-12-02" version="1">MMKLAFFLWFCFLFCVIGASNDGDYRDTFCNFKNDGVYADPYDGCKGFIHCHNYHADYKLCPGGLLFNAKTGMCDWPGNVTCPIGKEAVFIEQSPSLTTHQQPTICSFHQFRMICAKAARPPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCB2</accession>
    <name>A0A6P8HCB2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane emp24 domain-containing protein 10-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116291097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554074.1">
        <property type="nucleotide sequence ID" value="XM_031698214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCB2"/>
    <dbReference type="GeneID" id="116291097"/>
    <dbReference type="KEGG" id="aten:116291097"/>
    <dbReference type="InParanoid" id="A0A6P8HCB2"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028159655" evidence="9">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031554074.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23663" checksum="6594762B2E727AC5" modified="2020-12-02" version="1">MRVPRSIQLAVFLIICITSQLVQSISFALKANTKKCFMDGAKNDIPVKGEYYVSHNDRYAVKLTIKDARPDVNDLLYNKDNADKGKFAFTFDFDGVMEICFENKAPAGSGADRIVSLNVFLGFETKDYKDIATAQKLAPEEANVMRLSDMSQDLIKSFGWLIVKGDERHIANESTSGHILYLGTFLSFLLVALTAGQLIYLHRFFSSKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HED9</accession>
    <name>A0A6P8HED9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM161B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116291111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM161 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554091.1">
        <property type="nucleotide sequence ID" value="XM_031698231.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HED9">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116291111"/>
    <dbReference type="InParanoid" id="A0A6P8HED9"/>
    <dbReference type="OrthoDB" id="2150121at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051655">
        <property type="entry name" value="FAM161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019579">
        <property type="entry name" value="FAM161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501:SF1">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10595">
        <property type="entry name" value="FAM161A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="718"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554091.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="88968" checksum="82D69F3904BFE238" modified="2020-12-02" version="1">MATSHGITVVKNLCYTAPRKPKTKLPATENERTDRGISLEHSDGEERPTSSRSRGTKVHTPKAMMESLKELQGMDEKDFYRHLLALKKEHKKTLKTVEKAYYSELGKQSSGFDLDENTRISMEDGEQMKKFATEKYIRDDYDPYEVGYQELLESDLLPATDLVRDMSTRQQEEDKENQGSPDDDRQDRRRSHSDLSDNDSWSEEELDLPKKRPQSRDGRVLYKEMLPNRSSALDTVESLWQDFSVYDYPRDPSSPPKASEPLDTWSPCITIPKPFTMTIREARKSKEKKTRSQRLLEEELKLKKEKEESELQKKFRSQPVPATTFLPLYDEITRQNEIRRQYVKETSKALLKSTEKPFSFVKREEQKRSLTRSKSLSSLSDLTPKKEKKIFKANPFPAHLFDLTLADKLAEQDEYRTIKVRMRAEETLANSRLPMNMEGRGRKYTIGKLRNKAMKEKEKKAFMTKDHTFRPQINQEIPDFDNLQFQFDKELRKKKKEREPTVVEPFNLRTTALSSMRKSRTLERSSADGRLWSRRRSGSRERPSSARSLSRETPSSGRASSRERPASASFSYSSDILPYGTTESARLRDSKIRQSLEEKRAKETEELKEKRRKEQRLKQLRSVVSRKAMANDNSWQLRKTSDVKIKSFREADKARREEYQQELEEIQGRVEKRPLLFERQSQLNAKRCAERKYEDILRSAGVDEQLVRSLVTKDGKIIDAESEDELSDSDTEHYTTGSLSKDPRESRKDDDSEIDEDIXYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFJ1</accession>
    <name>A0A6P8HFJ1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116288667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551350.1">
        <property type="nucleotide sequence ID" value="XM_031695490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFJ1"/>
    <dbReference type="FunCoup" id="A0A6P8HFJ1">
        <property type="interactions" value="1294"/>
    </dbReference>
    <dbReference type="GeneID" id="116288667"/>
    <dbReference type="KEGG" id="aten:116288667"/>
    <dbReference type="InParanoid" id="A0A6P8HFJ1"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551350.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19405" checksum="1EDEE9AD94FE3A26" modified="2020-12-02" version="1">MAAVLGRLVNSTCRRSVGLITQSRWAYTVEKEPMKSSVTFISEPKEGQEEQDIPPYVTRYSSRGFRIKNVKVFGSVAIVPDNFFHWKIHNPNDITPESLKLFTLMDPSIEILVIGTGDKIVQLSPEVHSHLKENKIMLEVQDTRNAAATFNFLLEEERLVGAALIPPHTEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGE9</accession>
    <name>A0A6P8HGE9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116291831</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554906.1">
        <property type="nucleotide sequence ID" value="XM_031699046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGE9"/>
    <dbReference type="GeneID" id="116291831"/>
    <dbReference type="KEGG" id="aten:116291831"/>
    <dbReference type="InParanoid" id="A0A6P8HGE9"/>
    <dbReference type="OrthoDB" id="5843397at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF125">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027650889" evidence="8">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554906.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21257" checksum="A9B4DB7B9DC7C21A" modified="2020-12-02" version="1">MYTFIIVTVFLFISPKDIGKLTCEAVPVIVKEGDNITLNCSASAYPPANYTWKSGNDIANTATVILPASPDLHDKSFTCTAANSRGSKNCSTAYVNVLYFDKNICKPSKLEWVSGNESRKVTYAIKGLCNPTPNLTCTSDVTDVSFGSDQYNVIVKTTVTGNKINYSCVFSNEVGNCSMAFIIWKRSKYSLVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHP3</accession>
    <name>A0A6P8HHP3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Scavenger receptor cysteine-rich domain superfamily protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116292707</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555919.1">
        <property type="nucleotide sequence ID" value="XM_031700059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292707"/>
    <dbReference type="KEGG" id="aten:116292707"/>
    <dbReference type="InParanoid" id="A0A6P8HHP3"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000009">
        <property type="entry name" value="WC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058390">
        <property type="entry name" value="DUF8077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26284">
        <property type="entry name" value="DUF8077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028400247" evidence="12">
        <location>
            <begin position="26"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1604"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="31"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="13">
        <location>
            <begin position="142"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="13">
        <location>
            <begin position="303"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="476"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="585"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="692"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="829"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="13">
        <location>
            <begin position="942"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="1116"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="1227"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="1337"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="69"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1407"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031555919.1"/>
        </source>
    </evidence>
    <sequence length="1678" mass="184528" checksum="27EC7A8E84269327" modified="2020-12-02" version="1">MIQLSLLSTLVYIVVCIVSISKSNSVSPGDVRLMGSSFSNMGRVEIFHNNLWGTVCDDYWDMKEGNVVCRQLGYQGAIAVYSSGFFGAGSGNIWMDNVRCTGLERSLSSCSHPGWGVHDCSHSEDAGVACQNYTRHDHTGSGSCSFESGPSLCGYQNVNGDDFDWTLISGSTLSTNTGPQHDHTTGYGHYIYIESSYPRRFGDKARIISPQITGGKCLQFFYHMKGSNIGELNVYLKYGNNQTMIWQKSREQGLIWILARIPIYGLSTFKVMFEGVVGSSYQGDIALDDIEILNKTCLPANSGNCTFDDGHICGYTNDNDDDFDWTVNSGSTPTYNTGPQHDHTSGNGYYIYIRTSWPRVPGEIARLVSPEIFGAKCVQFYYHMKGSGIGELNVYVDNGISKLILWQLIGEQSSTWNKGMVPIKGLMAFKVIFEGVSGSDYRGNIALDDIAVLNQTCDLTPSNAKATPINITSNTVRLKGGNITSAGRIEVFHDGRWGTVCGSNFPLLSARVVCRQLGFLDVEILVQCCSIFPAGNGRILLEDVRCRGDEPSISMCSHKGWGVTSCRHRRDIGVICKTNNTLRNVRLNGSSNDFEGRVEVQIGGIWGTVSDLGWDIYDANVVCRQIGLAGATGVYNGAHYGRGSGPVWLSNTACNGDETALWKCNLTLNTNPHAYAPWNPHRRDAGAVCYDLRLTNGRQPGEGIVQIKYLGTWGTICNDGWDINDAKVVCRQMRYSRAVSLRLGYSVTPSAGINPLVTRLKCKGDEPSIGLCGFQHLSSVAHTCTHLTDAQVICAGQVPTIVPRTVKSHRPTAVPSKRPTTPKPGPNDVRLVGSTDKWQGRIEIFHNGVWGTICDDQNEKHIGTVVCHQLGYSDAIVMYTNSAFGKSNSTIWLHDVRCKGNESRLTSCQHSPWGERDYYCDRYDADLGVACVHSSTHVASPGSCPFDANLCGYTNADDDDFDWTRHQDSTPSFSTGPAHDHTTGVGQYIYIETSSPRVQGEAARIESPTITGASCIKFYYHMKGETTGELNVYLDNGSEKKMVWQQIGEISKIWNLAAIPINGLKSFKVIFEGVAGTSYSGDIAIDDIQTLKTACQLVPANAKPKPENPKNNSHSIRLVGRNGSVLSAGRIEVFYKGKWGTICGNKFPISSGRVACRQLGFLDVEMVLPCCTMFDPGRGRIWLDNLNCEGREPDITKCAHKGWGITHCVHSSDVGLICRTKDTLREVRLVGSSNDYEGRVEVKIAGVWGTISDLGWDIFDANVFCRQLGWAGASGVYNRGHYGLGKGPIWISRVSCRGNESALWKCNLTQHQIQKSQSRQWYQNPHERDAGAECFDLRLVGSKSKSEGIIEIKYLGTWGTICNDGWNMNDAKVVCRQMGYSKAGSIKLTSIVVPNNISNPLLKGFQCKGDEPSLGICSFNIIMPYSKSCSRSSYARVACTHPISKKCNARCHSCQKTVKYGGICVCSLEHTDVIWCDAFLGRNVIDVQVLNRSLSQWNAGEFKKSLANQLNIYCQNQTCASHSKFDVEDIIIVDNYPKXSKGQSFILQFIVLDEDSQSPISKGIIYSMFKHDHTLAGYNINLAYNHDKPLAHARKGTSSKNLKLAISIAMVVVIAGIALTIFLVFRKKKNKKLRSVVRYRAPNSNGGSHNYAVYGDGNVDDDQLLDLDNDEAPILPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHR0</accession>
    <name>A0A6P8HHR0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripartite motif-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555376.1">
        <property type="nucleotide sequence ID" value="XM_031699516.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292240"/>
    <dbReference type="InParanoid" id="A0A6P8HHR0"/>
    <dbReference type="OrthoDB" id="27136at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
        <property type="entry name" value="RING-HC_PML_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="384"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="484"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031555376.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="63210" checksum="866E60E62850BE2C" modified="2020-12-02" version="1">MKSFVEDIKKDVRCPLCNDTFTEPKILSCFHTFCKPCVKRHAEQVDQINIFKCPRCKSQTSLPELSSIEDLQPSLIHSRIAKDLALVEGEKXCSVSESHSSASWYCFDCDRSMCDECEKNHSVFIKDHKIVGLADLKKEDIEFLITREXPCTSHPHHRLEFFCEDCDAMICRTCLIDHKDHKTMSLDKFVSIKKAELSKHLQVLEQLRLDDKEKQQQVKIANTIKQQGEKAKKEVKDKTKKIIQILQDNERELLRQIDXNLEIATTNLNVMHHIPAVKEYIKNVMERGLASEMMNIQETQCSQKLGIAVNRDNSRIAVSNDSSDCVYVFTTDGDLLLTYGRRGSAQGQLYGPEGLAFLNNTDLVIADYGNHRICIVNTTTGTLVKTFGNRGNRDGEFCNPYGVHVDDDGNIIVCDSDNHRVQVFTRDGDYQYQFGLTTQDAFDPIDVITHDGLFYVGDYNNHVIHVFEKKGNVPTRISMIGGQGRADGQLNGPWGLAIDNDHHLLVCDYGNNRVQKFRLDGRFVGKTCDVTKNPRYITVLKDGQLLVSTSGSGVWCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIN5</accession>
    <name>A0A6P8HIN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116292510 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555711.1">
        <property type="nucleotide sequence ID" value="XM_031699851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIN5"/>
    <dbReference type="GeneID" id="116292510"/>
    <dbReference type="KEGG" id="aten:116292510"/>
    <dbReference type="InParanoid" id="A0A6P8HIN5"/>
    <dbReference type="OrthoDB" id="5974715at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555711.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="49305" checksum="030C1B79220DC17F" modified="2020-12-02" version="1">MATIFIRRRPDSVMEWEIEDVLDWLIEFQLERFCKRFQSHLITGPILLQMDDLLLDDLQINSIAERQVLLAESRRLCLHELELVDRALEYKQKLEEIPKSKRDGNTIKDIKGISSHPDQLEKAFVENDMSTYRTTDENVKRNPAAACLGKADEVATRATLMVTILSQENSSLREQLQKSSKKDLCINKLQKEISQLKSENYHLRSKAHALEMENKNVLDELREISEKYEKIRNCKDIIDKLKQENIFLQDKFQAFKCKTIERELMRSFCHGIKNDNSCSLQNSHVEDCHSDCKQEENDLHLINKVYTANKRCAELEDTIRRLYAELLLTEHGKKYLESPNACIDKAEEEQAPSEPEWPSLIGRLPTKDAILEKSDEQGLGIVNRLTTQGLPTDSDEDIWRIQSINSNSSLKGFGGSDDLVFHKWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ12</accession>
    <name>A0A6P8HJ12_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyaluronan mediated motility receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031554848.1">
        <property type="nucleotide sequence ID" value="XM_031698988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ12"/>
    <dbReference type="GeneID" id="116291779"/>
    <dbReference type="KEGG" id="aten:116291779"/>
    <dbReference type="InParanoid" id="A0A6P8HJ12"/>
    <dbReference type="OrthoDB" id="6003602at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554848.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31259" checksum="2331363CFE9DC504" modified="2020-12-02" version="1">MDRNHDQNNIEAEIRRNEERIASLEKDLKESLGSNKDLKDRISALEKEIQDLKDENKLLKKQRQEMEKGMENLEKENKHQRQKMEKRMENLEKEIEHQKAVLVIVQIGTALQRNLCKYVLGEHFKENCFYKFKEIRKYIQQDLKNDRKAQESAKKRLAEIKEKIPWDQSLVNSLKNLNQTRIGIAHPELSSEKIQKATEVLREIGELDDELVVKLNTLKGQWKTSEEMLKAAGGPEDGPEGGTMNWSTVGQSQDTYASRAAGGLYLDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJE4</accession>
    <name>A0A6P8HJE4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-secretase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116293238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556504.1">
        <property type="nucleotide sequence ID" value="XM_031700644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJE4"/>
    <dbReference type="GeneID" id="116293238"/>
    <dbReference type="KEGG" id="aten:116293238"/>
    <dbReference type="InParanoid" id="A0A6P8HJE4"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050435">
        <property type="term" value="P:amyloid-beta metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000007">
        <property type="entry name" value="Beta-secretase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027709400" evidence="11">
        <location>
            <begin position="23"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="78"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="109"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031556504.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="62941" checksum="D1C819CC52F8A268" modified="2020-12-02" version="1">MVRRWVLCCAYLMFTFVHLLDGQLAGVERAKSTMFSFDIKKKVKHHNHYKGSQNKPLRPPYIKEEEMEFILRSTSYAYVIELDVGSPPQKLEFLIDTGSSNMAIAGPNCEDEYGRKCQIDTFYFPSKSSTAKNLHIPIETQYGKGAWSGNIYRDIVGFPGDGPKTVAEFAVIRNEKDFFLKNSINEGILGLAYRSLATNGVEPLFDQLVQDGKVPNVFTLGLCNGMGQIWLDWPEQETFDGPIHFTEINQETWYSVTMTGIDVAGNSVGLSSRFFPDAIVDSGTTDILLPPIVYAAVINELKKRGPPVDERFWKSYCVDTDPYQWPYITIYLTDMRGGSFGLTILGKHYVRKQDDFHCLSIGLKPSGAVLGEVSMEGNVVIFDRANQRIGFAPSNLTHPEEGPCGNPMRVNNTVTGRLHKYCKATDMPRESCAMSCDPCIKEGGVWCPNGKVVVWINGVRSYLSTTKGFCWQGGLFMLDDAKVQTFLKGHGSAEFQAYCDSLLPMYKQCAVDGVWVVLMAGSLIFLVIMVVLYFCCRRSMLKARQDNYQVNARENDDQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKN7</accession>
    <name>A0A6P8HKN7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031553165.1">
        <property type="nucleotide sequence ID" value="XM_031697305.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116290301"/>
    <dbReference type="InParanoid" id="A0A6P8HKN7"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553165.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="34676" checksum="0215FD1E5D856B9C" modified="2020-12-02" version="1">MAIPLCRKDGTEGTATIXFEYENTTSKFYGCIVKNDNDLCEFIRDHIKPSADRNLFSKDNTKYFFYMNFEETITKATSFTVTCYRFSKVKPKKKRKRSFSQKDFVKVQEHIFVXCNFENFNGSKFLETHSKKLLVAQTLNTTDTTNIELLSLVQDNKNKNVLSFKSIPLTVNGQTFKVPEEXYQNLVNAGPVLKDGTLVGSFEKKTNNEIFISIFEMTSASGTDGGFPGRETGQAAGTQPPTPGGGTGQAADTQXPTPGGGTGQAADTQXPTPGGGTGQAAGTQPPTPGGGTGQAADTQPPTTGGRIGQQNNKRQVCSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL15</accession>
    <name>A0A6P8HL15_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116290479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553377.1">
        <property type="nucleotide sequence ID" value="XM_031697517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HL15"/>
    <dbReference type="GeneID" id="116290479"/>
    <dbReference type="KEGG" id="aten:116290479"/>
    <dbReference type="InParanoid" id="A0A6P8HL15"/>
    <dbReference type="OrthoDB" id="412369at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033540">
        <property type="entry name" value="MALT1_IG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF37">
        <property type="entry name" value="MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="148"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031553377.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61934" checksum="8D358893D1671D0D" modified="2020-12-02" version="1">MADKSKTSSKLLVKTPLSNLNPNVLEELGMFLNPRLISKDVRTLSGKLGYSLRRVQNFERERNPTACMLEDWSTCYEEGQEKTVSELLVKLEEMKRHDAVDFLKPYEFSEVQQESSLQPEENDLPIHEDSLVNTLLEAPRFTEIPVVTDKVALVIGNMKYSHEKLNQLMYPEHDARDVAAALHELEFKVFSLVNLTLSEMRITVHSFCRLLGKGVYAVLYYAGHGYEDHGKNYLIPVDADLSFKREDSFCAQEILQTMQECNTSLNLLIIDACRVRPPTKDQIPTFIKRGTNGNNIFAYSCCSQQVAFEEHDQRNGLYAQHLLKHIRRNVRIENILMDVAADVALTISYCTDNSIHQRPCHESDAYIDCRLTDPIIPGVLQDVDYHERMQLWQKAHTLPDPFVILENEDLHLKVQFIAKFSNVMEVLLTLCNKTSLPMKDCVVELIVDSPVCSDITMISGDEVKPGEQLKQVVQISALQKLNDYLAVDLQIFYDFNGELVSWTSSKVDLRTPLISSVFAEWDWWVTCGRAPPTKTQKPKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMS2</accession>
    <name>A0A6P8HMS2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal peptide peptidase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116294244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557659.1">
        <property type="nucleotide sequence ID" value="XM_031701799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMS2"/>
    <dbReference type="FunCoup" id="A0A6P8HMS2">
        <property type="interactions" value="2369"/>
    </dbReference>
    <dbReference type="GeneID" id="116294244"/>
    <dbReference type="KEGG" id="aten:116294244"/>
    <dbReference type="InParanoid" id="A0A6P8HMS2"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF22">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557659.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="42353" checksum="3E347B2D49111F87" modified="2020-12-02" version="1">MEQAIEHHWFYMLLDTSRMLTIIISILLIVYGSFRALGLDSACKTENESSEGQEQDKNGSLLSGVMDGFQTITTAQAIFLPIGASCSLLIMFFFFDTLQFFFALCTAVLATVAFSFLLLPVCQGLLKPCGKNNNHKVSLGFCGRFTFAELMSLLFSALLVMVWILTGHWILMDALAMGLCVSMIAYIRLPSLKVSTLLLTGLLIYDVFWVFFSAYIFKANVMVKVATQQAGNPVAFVANKLNLNSFMNSSPQISLPGKLVFPSQERGRFSMLGLGDIVMPGLLLCFVMRYDKYKKMQAQAPETESKITYFHCSLIGYIVGLVTATVASEVYKAAQPALLYLVPFTLLPILIMAYIKGDLRKMWQDPFIVNGGILKAKFMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMV2</accession>
    <name>A0A6P8HMV2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293713 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557036.1">
        <property type="nucleotide sequence ID" value="XM_031701176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMV2"/>
    <dbReference type="GeneID" id="116293713"/>
    <dbReference type="KEGG" id="aten:116293713"/>
    <dbReference type="InParanoid" id="A0A6P8HMV2"/>
    <dbReference type="OrthoDB" id="100767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234:SF5">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="282"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557036.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39551" checksum="715DA75E27B02A47" modified="2020-12-02" version="1">MDPRESPEVLISDGDGLLSMNTLIERSKAVCYIQVIVKDPMTNTDRLRRGSGFYSTVLINQIEYLGIFTNNHVLSNEIEAQQAEVIFDYDKSSYVNEQVKTVSLRPDLIFKTNKDLDYSFIGVQKENIEALHPGVNPIQFKPEPKISGGDEVFILQHPKGRPQEFSHDKIMTVMPPFVLYKADTETGSSGAPVFYKLNLVAIHQKGSEEQQYNKGVLCSEVLSHLNTGKYTKPTAFPIQDSQGEEIDKDSISRKQQKMENNVSLLVSEGDLEELAKEIIPIWRHLGRKLGLDNSRIEEISKDYANLGIREQAFQMLLSWKESSPNPSYGVLGNALIILGKRNLAQRYCHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNS8</accession>
    <name>A0A6P8HNS8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NEDD8 ultimate buster 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116293410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556693.1">
        <property type="nucleotide sequence ID" value="XM_031700833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNS8"/>
    <dbReference type="FunCoup" id="A0A6P8HNS8">
        <property type="interactions" value="2145"/>
    </dbReference>
    <dbReference type="GeneID" id="116293410"/>
    <dbReference type="KEGG" id="aten:116293410"/>
    <dbReference type="InParanoid" id="A0A6P8HNS8"/>
    <dbReference type="OrthoDB" id="434245at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000058">
        <property type="term" value="P:regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17062">
        <property type="entry name" value="Ubl_NUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039749">
        <property type="entry name" value="NUB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041207">
        <property type="entry name" value="NUB1_ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948:SF3">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18037">
        <property type="entry name" value="Ubiquitin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="436"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="498"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031556693.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="69292" checksum="448ECB550B0E7753" modified="2020-12-02" version="1">MMSDPESHFELILSRVREQLNQERLQLWLPPFTVEGESKGRYPEELVSRFSKTLGITSPTIIEAFEHLRQHALDKLEARNRFKESGIATLKVRVAGSQIGKIDIIIGLQCTGAELIKKISSEFHVDVDRLKLICNGQVINEDNTLESQSVKNSNQILVIQLSETEVEARKKQQENEKMTSQVMRTRQAAEALSKRTDAGKSEKMQYFLEINDQEGRPLNLPENERKALALAMTLHEKGKSILKHKNYAEALVYLLEADKEFSQCRAEILNAVDNYAILCLDIVWCYLCLKSINDLPDAEKRLETCQECFEKSYGRNLERLTVVRGGTGRELALLVRLHALRAVCAYHKRQYDVAMRTLDKAEQEIRKLHVDDDHLSQLVSMGFSIREARLGLRACDGDVTIAIDYITRTKQERKERRERERKERRRERMQRRLGKTADGEWVNLSRLEDLVSMGFPRQSAAEVLRQSNNSMDKALQVLQDHPELLDLPPDRLGDLAFDVPDELVAQILSMGFNIEAAKEALRRFGGNGRRAIEELVAAGGVLPSSSSSSYDEQSGSSSENEDPELEKAVEELVPDITSDEDAYLDLALEDEAAVVAEYKALLLSRGYGMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPI1</accession>
    <name>A0A6P8HPI1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558289.1">
        <property type="nucleotide sequence ID" value="XM_031702429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPI1"/>
    <dbReference type="GeneID" id="116294770"/>
    <dbReference type="KEGG" id="aten:116294770"/>
    <dbReference type="InParanoid" id="A0A6P8HPI1"/>
    <dbReference type="OrthoDB" id="5964615at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF335">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="239"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558289.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44240" checksum="F88FA28180FA3AF0" modified="2020-12-02" version="1">MVGVIYESHEIENLALNTPKILSSIFLITFLIFASWEAQEIIYLASNTSILRDVKHGLHFANFVKHRFKYLKVTPFMSSLIPNQKKCQVFCVQNLQCLSLNVAVFPNSDDKFKCELLATDIFNSSSNITNDVNYNHYSFETKCHDQPCENNGTCVPNYKTNTYSCHCQCPYYGYNCEKVLAKTWISISNCSFDYRCPDYARKRVQTYALPEPPFANVCPDNVVLDSEIQNCPTLTPTGCEGALGMQDGRILDSQISASSYYNIETYPWYARLHRVPAQSDRAVWIALRAAAGEYLQIDLGSVKTITKVATQGRVDRLQYSNKYSLAYSVDGTVWVHYHNNSCIKELPGNTDRNTVVTNVLDIPFKARHVRIIVKAFLEHPVLRCELYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQH8</accession>
    <name>A0A6P8HQH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Mucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116294362</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557816.1">
        <property type="nucleotide sequence ID" value="XM_031701956.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116294362"/>
    <dbReference type="InParanoid" id="A0A6P8HQH8"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AMOP" evidence="14">
        <location>
            <begin position="273"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="15">
        <location>
            <begin position="419"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="823"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="871"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="995"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="17">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="17">
        <location>
            <position position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031557816.1"/>
        </source>
    </evidence>
    <sequence length="1283" mass="146263" checksum="6378BA9490747401" modified="2020-12-02" version="1">MYPYGTNANDKRDTEYGYYWYSKCPEIQLDARGMVFFGRRHYKLYVCRNGMISFNHPWYRRWPNNFAKRYWFDEEAILAPYWALVDRVYSFRSGVSKVFYHLYKESDPAAQDVLTRAVKDVNKHTQNNVLPNEFTEATLVLVVTWVNIRHWYSAWRSALRDKYNTFQAVLITNGEFSFVMYNYPKNGIQWSVPAKREDYGRYYNSKGLPVVGFNAGHGNDIYYDHPRSGDVMVVDIDQIEGLNVFKSPDSQTIQATGNGMQGRVFIRLEDSRGEEDHRLRCVNWYYQQGDARAFTQSLEPCPCSEWQAWRDRRFRFTTWSWPRICYYSRFPSSWGWGQECCYKFERRQHWWGWGWWISFLANGFPDGGNAHRFHKHRYPTEYQNDDKQAYDNCCIKSNXCWMYQEARPSDTCSRYIPPRWSWFWGDPHFVTLDSKNYTFNGLGEYVMLDAKDGYFQLQARTRLAKGNGTATVFSGAVAKENNSVPVQVTLPYDNETMEVLVDGKPFNFKSLTNESQDLDNGSVTVSKPXKQCLEMSFPSGMSVTICEKQNILSIVTAAPESFKNKTKGLLGTWNGNPEDDFTLPDGTVLPHNMRGRDIHYKYGMAWQVTNETSLFTYKEGESSDTFLNKTFRPMFLEELKFYNYSLRIEAETKCQGDASCLFDAASTGDVEIGLSTKQLGSQLVNDSKKMSNDPPKISNSSSVIELTVNTTATVIVEVTDANDDSITLNVTGLPADXQVRHSNTSYWNINWQVTTKKLDLQFIASDGESVSALIPKIYLCACHHGGHCEKPSKITGADSGEEKFIENACNCVDGYTGKYCETDIDACEANLNPCYPGVDCIDLPPPANVTDGYECAPCPDGYTGNGASCKDIDECGDDNEDCDQLCLNKPGSYECSCKSGYQLQADXKTCQDIDECVPASDCMHKCTNXPGSYNCSCNDNFKVDPGNPKLCVPTNPCQKDEXQCTQVCYKLSDNQQKCSCYKGYELKDDEITCQDVDECATKNXCNQRCHNTKGDYYCSCLQGFRLSSNNKTCIDINECMEWTFNCSDPSLKCVNTDGSYKCECEEGLYWNVTLNKCIGLKKGQKPPPPPPAPKPKKPDQNETMNAVNITVKNFNASKWNKPKEEKFKNAIAKAITTYCNEEGNLCSSPVKRARRSTEFITWTQDNIHLMPGFPIQINSEKFPASSLVARIAFYINFPRAVMLQTGITVNSEIVLKILNASRDDIEKALNASIIDFSLYKEKPREEENTKKEKDMLPIIYYHRSCCWGNCLHSVDNLCRSNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR59</accession>
    <name>A0A6P8HR59_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Lactadherin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC116292029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6 7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555120.1">
        <property type="nucleotide sequence ID" value="XM_031699260.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031555121.1">
        <property type="nucleotide sequence ID" value="XM_031699261.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031555122.1">
        <property type="nucleotide sequence ID" value="XM_031699262.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031555123.1">
        <property type="nucleotide sequence ID" value="XM_031699263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR59"/>
    <dbReference type="GeneID" id="116292029"/>
    <dbReference type="KEGG" id="aten:116292029"/>
    <dbReference type="OrthoDB" id="5988052at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653090" evidence="1">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="129"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031555123.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33302" checksum="B28C989CF0E68843" modified="2020-12-02" version="1">MMYSVLSLLMSLPFILHDIWCLDCPSTYTQTNFILKHHVLSSTTVKNYQECYDKCASTTDCHSMNFYDRSQRCELNKGSHLSNPVDLVYNEEGTYSVHDSRSVETCSDKYCSTDTICVMKNNTFECKDCAFAFGMGVDSRKIPNSAITASSTWGSGGHEPWRGRLNNYPVTTPYNVGVDVGCWSARSNTVGQYLQVDLGHVVYVTMVATQGRPYSHAQYVRKYSLAYKNSDNSFVDYKIANIVKIFQGNTDLSTIVTHRLPDKIKTQYIRFVVREWYGHISMRAEVYGCQIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR94</accession>
    <name>A0A6P8HR94_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558889.1">
        <property type="nucleotide sequence ID" value="XM_031703029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295257"/>
    <dbReference type="KEGG" id="aten:116295257"/>
    <dbReference type="InParanoid" id="A0A6P8HR94"/>
    <dbReference type="OrthoDB" id="5986954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558889.1"/>
        </source>
    </evidence>
    <sequence length="772" mass="87625" checksum="E76B95E39C79DA76" modified="2020-12-02" version="1">MEGFEHASQGTDVFAAPXPTASAAQPWSANEEIYPPCELXSKAIPEPTIPPDRNAATTGTVRPPKESPKPSQLENPLMQLADLLSERRTRDSLPLPEPEIFRGDLLHYPKWLKSFQTIVEEQTTKPAKRLYYLGRYTAGEAKEAISGYVTLDTEEAYQEAKAVLKNRYGNSFLIANAYRKKIXEWPKVQPNDGVSLRKFSDFLNQSLKAMRTTSFLDALNDPDENQKMVKKLPPYLVNRWAREVDHWMNQDTPTAGYPPFSQFCSFIQNEARIACNPIISMRAFKAESESKHKNSAHDGRTRPYGSVSHATKTASRSDEKRQDXRSPTCPMCKDSHYIETCPQYLKLTQKKRKEFIIKAGRCLGCLRWGHKNNVCRKKVSCDECKGPHPTSLHEXTYVPREQRHAEKEPPSPKTSNRIQSSPRDEVYSVSSLIVPVWLHHASDPERKLLVYALLDDQSDACFIKDSVVKKLSLTGPLVDLSVGTVMGEGVERCMKIRGLTVCGLSENADIPLPGAYSLDNIPARRNQIPRPEVARDWPHLEQIAERLMPYREDVEVGILIGSNCPRAIKPRDVIPGREDDPYGQKTALGWGIIGXVDPSRLENEDHLYXTNRAVTQSDIRDNRCHITFQTESKEIISPALINQMFMTDFIEKSSTNQSEEKSLSRDEMNFIKILESGVKHLDNGHYELPLPLKTDQVSLPNNRQMALSRLNNLKRRFDADSTYSEHYRNFMQEVISKGFAEEVPEXELSINDGTVWYIPHHGVYHPKKPGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSF9</accession>
    <name>A0A6P8HSF9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031558133.1">
        <property type="nucleotide sequence ID" value="XM_031702273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSF9"/>
    <dbReference type="FunCoup" id="A0A6P8HSF9">
        <property type="interactions" value="854"/>
    </dbReference>
    <dbReference type="GeneID" id="116294635"/>
    <dbReference type="KEGG" id="aten:116294635"/>
    <dbReference type="InParanoid" id="A0A6P8HSF9"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00503">
        <property type="entry name" value="Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000002">
        <property type="entry name" value="Frataxin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031558133.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21933" checksum="2FDEB3B29E19A6E9" modified="2020-12-02" version="1">MMMLRSTKNWYIKNNAGLRAIYTAMCRKSYLNNNIKKISIKYSQQNVKNIASFQSIVSFTRSLTGFQNVLSFHNVTDETLEGLSDFFDDLSDHYILPSLDDYDVQFGDGVLTVKFGGEVGTYVINKQTPNQQIWLSSPKSGPKRYDFVGNKWVYKRDQVSLHELLSREMSNITGQDVDLTHLPYGGMTSTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUT5</accession>
    <name>A0A6P8HUT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116295403</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559058.1">
        <property type="nucleotide sequence ID" value="XM_031703198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295403"/>
    <dbReference type="KEGG" id="aten:116295403"/>
    <dbReference type="InParanoid" id="A0A6P8HUT5"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF35">
        <property type="entry name" value="LICD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="3">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559058.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51771" checksum="83D1218DD276F39D" modified="2020-12-02" version="1">MSXKIFLAKIGLAVFMILFLVKWIKKFDGCNPMTKCVGRTTGNDEIGSEKIKKSLQSSGLQSVIQDVDGRNNAMENKDIPSLNYNNKSISSILSSLRTPHEIQSEVLRDISRNGKTQRDSTKDVLGSKGNHVNISDKLTLPRTTPSSGFQYILQNKDMRKNSKKNIPPLKKKXKQKTNVKHIFRKSGTKKPSDDGSKRVQFEPKEGDMDEDSLQKYIERDDEDDSEDDSEDEEEDDITIYGPKRNSDCPRNHDRYILRDLLSFWDQKAKKHGILYFLTYGSLIGYHRNGDVLPWDTDVDVFVEAQSYRQIRDIAVPRNFKFSKHDKKTRIVVQTDVTFPSENRTRVSCDGRVVARNIDDCSFQDPMARLIRGNRHVDVFGVYRRNATFFYEPTLKHSFQASEFYPTKPCVFMGIKTNCPSNVPAVLKRMYGADFNVPAKICLDGKWEDRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV50</accession>
    <name>A0A6P8HV50_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TBC1 domain family member 2B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556555.1">
        <property type="nucleotide sequence ID" value="XM_031700695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HV50"/>
    <dbReference type="FunCoup" id="A0A6P8HV50">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="GeneID" id="116293290"/>
    <dbReference type="KEGG" id="aten:116293290"/>
    <dbReference type="InParanoid" id="A0A6P8HV50"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01265">
        <property type="entry name" value="PH_TBC1D2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000014">
        <property type="entry name" value="Putative TBC1 domain family member 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000248">
        <property type="entry name" value="TBC1 domain family member 2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000018">
        <property type="entry name" value="TBC1 domain family member 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="611"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031556555.1"/>
        </source>
    </evidence>
    <sequence length="913" mass="105365" checksum="13DF73B54351E23B" modified="2020-12-02" version="1">MEDSWEVLALPPEIEHSTLSQTNGSEANNSTPEDAEKTKQNTPKLCGFLNKQGEKGLIKTWKSRWFVYDEGRCRLFYYRTPQDHVPLGFIDVANATLSFQVENPERLNQFDICVAERNYHLQAKDKQTMMFWLQQLQVKRREFSRRRTKLAVQKREDSVANMQSTGGLIEQEEKEKSSQDKPESNKPEVQVMEPVPPPETVGQEAAMKSPSGGGMFNLSLTNIRTEFRNMSAKRVSTFFSGNQSLNIPQVVTEEVHDDGKTDQATTRNNHTQEGRTELQPQNSFHSHIKTLDKDNTAETTQPNDDKTHITTNSNTEAGTLAGTLRRKFAASRSSSAPVNPKCLECERLHTMLDTSEAQLESAREEITVRQEVILNLHELLRRFQLEKEESLQSDQKKMEEELKTNTAYTRKLEEQLKQLKEEHESSLKEKDIQLCGLMEQIQMYQEMTAVKDQVVVSLTNQLHNLESMYKNREGEEVGEEIEPESPSFRERENINSIHEMGRIKEACQAYALQNRFLNSEILELNRLRQDDEERLRLQAIKVATAEAEICKYKSKYLLVLREFQRPKQGSENAGPDDEIINRLLQDAMENESLDRATLSRSVELKTLTRAGIPHQYRAQIWKQCIEVYVRETKKVAGKDYYTKILASMAGKFSPAAKQIELDLLRTLPNNKHYDKPDSDGIDKLRRVLLAYSGHNPEVGYCQGINRLVAIAMLYLTEDEAFWFLVAVIEHIMPKDYYSKTLLAAQADQRVLKDLLAEKLPRVNTHLENLSVDLSLITFNWFLTIFVDSFPIETILRIWDCYFLEGNKVLFRYALAVFKTNEEQILKIEEATGIFNYMRQVPERIADHHALTQTAFQGLNPFPMQKIKTKRNYYLGLVQSELDELDRLRADYVMQRDDDKEGEILSESELTTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVZ4</accession>
    <name>A0A6P8HVZ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560584.1">
        <property type="nucleotide sequence ID" value="XM_031704724.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HVZ4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296668"/>
    <dbReference type="KEGG" id="aten:116296668"/>
    <dbReference type="InParanoid" id="A0A6P8HVZ4"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="101"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560584.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="65558" checksum="6C7330BB88558B44" modified="2020-12-02" version="1">MERLGPPNIKYRILFSPIWPVLALVFFITTIIMTALFIWMVAKPSQQPMTLSTRNPSXFEIPCPRQPPLLELPNPLPKAIKDSLTLIDDHLKSLAKTAQNKSAISVNIFYRDKVIWRGHYGSKVYXGSNAPDDDTRYRIGSVTKIFPVILLYKLYQDGMITSLDDPLSKYAPNFHINNPFTETNITLRQIASQMSGIPREASCGFSCNNTNSSEQLDFLKSQNLVIEPWTSPSYSNLGYAXLGRLLTENLLNTTFEEWVEKQXLQPLGMKDTGFEISKKVLENMALPYSPDGKVLPFMNVGWAAPAGQMYSTTNDLMKLAKMFTTVDGQGILKRETIHXXLLPDFITRDGLWLWGSPWEMRFVKGFLARQKGGNIDSYNAVFSVIPEMKMGVSVLVNAAYVFPARSMSCFVIADLIHSTVLPALNETLFEMRRHQSFPIESKPFLGEYSVTKFIKSTGKVFNSTITIKSNMDTMVAMMNHSMDSLSAGFVLKYIGKPLLLQATVISAVNSSCLFPHLGVLGMVEFNAPGPXGLCDGFSVIFFDSLFVGKRIKSSNKLPDTPFKEKISLWREEDFLFDQRFSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX11</accession>
    <name>A0A6P8HX11_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296034</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559856.1">
        <property type="nucleotide sequence ID" value="XM_031703996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX11"/>
    <dbReference type="GeneID" id="116296034"/>
    <dbReference type="KEGG" id="aten:116296034"/>
    <dbReference type="InParanoid" id="A0A6P8HX11"/>
    <dbReference type="OrthoDB" id="10023060at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="279"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559856.1"/>
        </source>
    </evidence>
    <sequence length="730" mass="83692" checksum="7BB7F457B355F4B5" modified="2020-12-02" version="1">MIPPMSDDERNVCEKYGIVEFPAILFFDKQEWDDSQKPVTLFQGQLNTGVYQIKLELTIRNTTATIFNLANFKSVVLETNVPTSPTAVTFYSHRNQRSLDYINIIDKAIKEFGRIDPSFQFGFVNLVDGSEVVFRHVNASLVSAVPFTIIFWQSKHQDDSKYIIKQALFNQGIPTSLNLYAFVQSNNIPLLVDTDMDTDWLDVKLEVCDKTANQENECVPRDNMTVVRSSYDSLLLEDTTRVYGPEPAPAEWKAIKMVGSANVSTDVKIPVVTDQTWAAKIEQSVRPTNAYGPKGNQDSSRKYLVSLVVFIKGQCGYCTKIMPVLQDIANSVKMIGASMYLMNCTTDPVHCDQFGITGYPTLTAFRSLSWSVVEQCYPSSQQSHYIRVDYHGAIVPALVLDWLSNLNQPAVNNQYMHDHLPDDLSQDVYLVATVYTRSLARQYLPSRLIDRWYTCQCYTLVCELLYGLVPCYALYTRDVADHVTGTRNEKDLVVSKLVLHRNDGVRATIFELGYNLAFTLGQESDSRLHMFHKPHRYNVDDNFNCEDDHRMCTEYAVQFVHDHRRLPVTQITTAIFHTKTGSQDRTREVFTQDLPVMLILARTQNISRDTHFYREITVAAYSLYQDIVFTTLNVDEFSFWASNFVPKGYLTKYAHDLSGSAPSLYHYPRLCLVRWQDHQHAAFYPPVSEMERLGTRVQERLEAIDSQQIIKFARDFLEDPGKMLIRTEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXZ7</accession>
    <name>A0A6P8HXZ7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116294139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557545.1">
        <property type="nucleotide sequence ID" value="XM_031701685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXZ7"/>
    <dbReference type="FunCoup" id="A0A6P8HXZ7">
        <property type="interactions" value="1490"/>
    </dbReference>
    <dbReference type="GeneID" id="116294139"/>
    <dbReference type="KEGG" id="aten:116294139"/>
    <dbReference type="InParanoid" id="A0A6P8HXZ7"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001252">
        <property type="entry name" value="Receptor of activated protein C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557545.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="34725" checksum="32251CD11643E3CE" modified="2020-12-02" version="1">MAEQLTLRGTLKGHNGWVTQIATNPQSPDIILSSSRDKSIIVWKLTRDDLNYGLPERSLQGHNHFVADVVMSSDGQFALSGSWDSTLRLWDLNTGVTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLGVCKYTIHDECHSEWVSCVRFSPNTGNPIIVSAGWDKLVKVWNLTNCRLKTNHIGHTGYLNCVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLGGGDILNAMTFSPNRYWLCAAAGPAIKIWDLEGKSLVDELKPEIINMGGKAQPAECMSLAWSSDGQTLFAGYTDNLIRVWQVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYX8</accession>
    <name>A0A6P8HYX8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP1R37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557817.1">
        <property type="nucleotide sequence ID" value="XM_031701957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYX8"/>
    <dbReference type="GeneID" id="116294363"/>
    <dbReference type="KEGG" id="aten:116294363"/>
    <dbReference type="InParanoid" id="A0A6P8HYX8"/>
    <dbReference type="OrthoDB" id="10034042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF9">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031557817.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="81781" checksum="E0EB1D3633E8174E" modified="2020-12-02" version="1">METGEDVLASAESTSGSDGVFSSANESHGSGVVASDTSESPGKNRASSKQQRKVYFPDDDSLVHSLEPFDPWKNVGNYTSEEVIDAYRSICSQLKVKPCEKLIKQLEACESFKERIDVIDLRGTKLDLKSCETLEEVLRKVRTNTLDLENTSLEDEGTLSILEMVEFYHSTCKLNLAYNNKIRVRGWQALSRTIKRTPCLEYLDVRHTVWTEQSIPFLGRSLRLNCPLTILHMEATNLSGRPLFLLANAIKSNQNLRDLFLGDNKLVPSDGQCIGAMLKGNEMLRLLDLRNNSLQDMGLGYICEGLVHQTQGGLQTLVLWNNQLTFHGMVNLGAALVPLKSLQTLNLGHNRLTNEGIHMLKDGLHLNKSLQRLGLLNTRLTSEGIIALAEVIADSKTMLRLDIRENDPYVGGLMALALSLKMNYSLVRIDLDKELKKEPGMETTQRILLADIYSYCQRNKALTEGKSQQSSVMPGVTPSVTPSVTPGVTSGITQGVTTGATQTDSGAATNERSSAETPCTSNDQPLIQLDNAPNRKEEHNMISKNSYPMPSRFRITRIYEGSDAVIPETSSGENSSGSEGEGLLVEIEPSSPAGISSNLENLELFDLESDSSSSQDTDSDSKLDNLPTCGSKESVDSMGTPFERPTGVPDRGGVDDCGFRSKDSVDSMGTPTSRPQEPIAALMQDHPAHDFERELDAMLASVNNSQQQANDNEFWFQQMDGIYNNSNNTNSNSLPTNPPTGDLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1P8</accession>
    <name>A0A6P8I1P8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116297581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561698.1">
        <property type="nucleotide sequence ID" value="XM_031705838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297581"/>
    <dbReference type="KEGG" id="aten:116297581"/>
    <dbReference type="InParanoid" id="A0A6P8I1P8"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="155"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="377"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="906"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561698.1"/>
        </source>
    </evidence>
    <sequence length="980" mass="113671" checksum="0907029581F931EA" modified="2020-12-02" version="1">MELKDRTSYDLMKDRHQDVEVQPYENYTYHVNGQHFTALQHDDKESILNHGNVENTKRKKRRKKRRSEVNPDLMSSPENDQSATDRENTTINRVPDQGRVLNKQKRMPLNSLGTSEELQKIEEEFCRQGAEPNKIDIRQQAIQQAIHQSKNESHEKKRHYDYVLVYKPGDLSTTQERLRETFEKSLEEEGFRIEKKYSTLHTFVILHCPFERLCIEAEHVILQMPLAGYVVPERNERSWLSRLGDKFKTDDEVDFVSAPFCVSKKEIYEGINDPETFFRPALRSLLVNHILITIDIRDKESRQLGQNPQGLPYLLMEKAYIDAFILHGKSKYDKMFPLLEDKEVEETFLYGQDVTDPRRSLHNTWLKWIKFQPLWKIRNYFGEKIALYFAWLGSMTFSLIIPMLFGLAVFLWGLIDAVDEHPLRQTNATITNITGKWVKNAFDNSITPYFALVICLWGTIFLENWKRTNARLAYKWDVDEFEEQEPNRPEYYGTEIRPDPITGQHELFYPFRLRVTKMTGSFGLLLFMVCLVLASLFAVIVYRIIAREDLFKSSGPFGPTIASITSTFLNTCSIMIMGKVYQVLAVRLTDWENHRTQTSYEDALIIKLFGFQFVNSYSSLFYIAFFRRDTASEGILGFGPNYNDACGADNDCMSLLSLQVAMLMIMKPLPKVFSDIVLPFIKRIWRQGCCNNKVDEADEVINHEVEDFLTYELHKEPLVDFTLSEYTEKXLQYGFLMLFAAAFPLAPLIALLTNLIDMKVDARRLLWINRRPIAFRAQDIGMWYGILEFLNIVGVVTNGFLVTFTSDYGKHWEGFATTVTFNKTVVNTVNNQTVVQLIVQQEPTFNRLWLLIGFEHIVFAIKFLIAWLIPDVPSDVRMAQRREKHHLADILSKAGMRKGPGRKLTESSTQSRRPLRTSQSSPVIITNTQANNGQLQRETGASSLLDRNNHVMPKTRLDPLPVNYVPKFKVNQRDSSDKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1T5</accession>
    <name>A0A6P8I1T5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ectonucleoside triphosphate diphosphohydrolase 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116295217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558840.1">
        <property type="nucleotide sequence ID" value="XM_031702980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1T5"/>
    <dbReference type="GeneID" id="116295217"/>
    <dbReference type="KEGG" id="aten:116295217"/>
    <dbReference type="InParanoid" id="A0A6P8I1T5"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF127">
        <property type="entry name" value="NTPASE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031558840.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14330" checksum="AFAD254E277AD786" modified="2020-12-02" version="1">MDTSDLKWENMYELKSSIFNIKITGKPPPLRKVYKVFKDSPFHVTGESSVSIMDGLDEGIFAWVTVNFLIGKFNHGVESLVGALDLGGGSTQITFYPKSEDTIANSPKDFTQKAKVFDQEYKLYTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2N2</accession>
    <name>A0A6P8I2N2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Glutamic acid-rich protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116298451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562794.1">
        <property type="nucleotide sequence ID" value="XM_031706934.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562802.1">
        <property type="nucleotide sequence ID" value="XM_031706942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2N2"/>
    <dbReference type="GeneID" id="116298451"/>
    <dbReference type="KEGG" id="aten:116298451"/>
    <dbReference type="OrthoDB" id="10058133at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029336">
        <property type="entry name" value="DUF4594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15635">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15635:SF12">
        <property type="entry name" value="HABP4_PAI-RBP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15266">
        <property type="entry name" value="DUF4594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031562794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562802.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="69524" checksum="23C69E133A1E9C69" modified="2020-12-02" version="1">MADKTTMKDVAGRGHDAVDCDRSKAMEEEKLLKERLLDEKMKLIKQKNEERLRRQKEIEEDIRCASLHSTQAAEEKPAVTEHKMAGIQKDNNSSVSRMRGRARGRILAKMAKEELQAHRFENKGKQTYEDLENEVQKKEIRNSPPRGGSSSFLYDERRVDMSKVSSRSSNSWGGSQFEDVVEKVVEKHAHQRKKDQNIEVSMTGKERKQYIEWKEERKRIDRERKLRQKSGENWKREWDREKVHKEFSSTHERHDQHHTRRSGQRFGERTRRKPDWDLHDDRVPEKDIHYTDNNRENERDNWEEINDQKNNIAINNEVEDWENSSSTGVERHIESGLKEETILSANLEDSTTRKVNKKDDSNTNNETNETVDNAAVNSEMSKEHHTTDMADSKEVKETFEPRINQEQEDIDIKNLTVTIDSKGKRNIFDELTNNDINSHPDKMEGTFSDDSKESKEETLSVKEDKVIEEAKPQRIHKKHRRREEKESPQSSKPQEKQDLSNEMVENKKINNSELERNTTDVKVESDSITNSMSSSSHHEKSEESLPKLEIKKAEENNEDVPDFLKTPQKKNWADCEFDEELDLPPLEWGSLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3C7</accession>
    <name>A0A6P8I3C7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116297837</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562005.1">
        <property type="nucleotide sequence ID" value="XM_031706145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562006.1">
        <property type="nucleotide sequence ID" value="XM_031706146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3C7"/>
    <dbReference type="GeneID" id="116297837"/>
    <dbReference type="KEGG" id="aten:116297837"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031562005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562006.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24256" checksum="6235DEAC94965087" modified="2020-12-02" version="1">MAPKRNNVIPNAHFHKDWQRYVKTWFNQPGRKKRRRTARKEKAIKIAPRPVAGAIRPIVRCPTFKYNTKIRAGRGFTLDELKAAGIPRKVAQTIGIAVDHRRKNRSTESLQANVQRLKEYKSKLIIFPRKAGKPKQGDSEAADLENAVQLQGEVMPIQQPSVQIKARPITDEEKKFSVFKTMRIERSNARLIGIREKRAKEKAEAEAMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3E8</accession>
    <name>A0A6P8I3E8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295612</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559350.1">
        <property type="nucleotide sequence ID" value="XM_031703490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3E8"/>
    <dbReference type="GeneID" id="116295612"/>
    <dbReference type="KEGG" id="aten:116295612"/>
    <dbReference type="InParanoid" id="A0A6P8I3E8"/>
    <dbReference type="OrthoDB" id="5982941at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001981">
        <property type="entry name" value="Colipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10041">
        <property type="entry name" value="COLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10041:SF5">
        <property type="entry name" value="LEUCINE-RICH COLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028433534" evidence="1">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559350.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21475" checksum="C319F10ABC42B938" modified="2020-12-02" version="1">MKSVFLVLCFIGATLAFEECSSGSECGKDRCCLFNKVCFPKLPKYAPCNTKSAQKCGCKDGLSCKVTRELTIAGNLIQIKQCMPANEDIKVEKLTNQDVQETLQPGSTNPAPNPAGRFYPGKKCQNASDCFWPNTCCLFESRCGFKLPKYFTCYFTSKHKCDCMNGYVCKTTTTVMLPVVGTPFPIKQCVPTSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4R1</accession>
    <name>A0A6P8I4R1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein C3orf84-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562873.1">
        <property type="nucleotide sequence ID" value="XM_031707013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4R1"/>
    <dbReference type="GeneID" id="116298510"/>
    <dbReference type="KEGG" id="aten:116298510"/>
    <dbReference type="InParanoid" id="A0A6P8I4R1"/>
    <dbReference type="OrthoDB" id="10045229at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029369">
        <property type="entry name" value="HDNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35539">
        <property type="entry name" value="CDNA SEQUENCE BC048562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35539:SF1">
        <property type="entry name" value="CDNA SEQUENCE BC048562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15115">
        <property type="entry name" value="HDNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function with conserved HDNR motif" evidence="2">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562873.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25355" checksum="99F427855EFAB924" modified="2020-12-02" version="1">MANVDEIQGSWFPTGFHGHFRSKTRTDFNIPYRQRAKPKPPVKFLNQTKERSNRHLFSRHDNRNAHSNVGDLEAFFNMGLGKRKYLSTTDQSIPSQHTKSTKDMLTWKGNENNAMVTTYRRQFDRRSMPAPGFNEYEPVHVRSNLHLQRRHFRAVSAPPSQRRTAPLLAWNEPDDSFSSRPGIGSHHLTQNQTFSHSTPARPSNTSNFTVAETITPLNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4R9</accession>
    <name>A0A6P8I4R9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neurogenic locus notch homolog protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116296086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559902.1">
        <property type="nucleotide sequence ID" value="XM_031704042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296086"/>
    <dbReference type="KEGG" id="aten:116296086"/>
    <dbReference type="InParanoid" id="A0A6P8I4R9"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="10">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="223"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559902.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50189" checksum="6C0F0FC3A700E73B" modified="2020-12-02" version="1">MERTKNSLELQCRTYFFIYFLGGFIIFTMVSDTKGCKVMVFKVDIQDKALENHVFKTEXAXDDFQCRVFCFLDDHCISYNFGMSRNNETRMCELNDSDHVMYPEDLVDRLNTTYKSAQNNCKCSKHSICRYNFAQETHRCECKPGFTGNSCENHINECASNPCQNGGSCQDHVNSYNCTCVAGFTGTDCQTDPCQNGGSCQDRDDSYRCTCAAGFTGTECQTDIDECASNPCQNGGSCQDQVNSYNCICATGYTGTDCQTDIDECASNPCQNGGSCQYQVNSYNCTCDAGFTGVNCEWLKVGTEVCIGSKDDQFGKFTIPVACHVLNFKLVYVSGGGISWRTGETKAYWGSTNIQNSKDLNLHITNNTNNRISPPPDFPLTRSTKGYMQYELPGVTNMDPELIFPELSPPLAVTAGKEFRIWVDQDLTNEYEGNNEGQTCAEVWIKKQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5U6</accession>
    <name>A0A6P8I5U6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EEF2KMT-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563313.1">
        <property type="nucleotide sequence ID" value="XM_031707453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5U6"/>
    <dbReference type="FunCoup" id="A0A6P8I5U6">
        <property type="interactions" value="797"/>
    </dbReference>
    <dbReference type="GeneID" id="116298877"/>
    <dbReference type="KEGG" id="aten:116298877"/>
    <dbReference type="InParanoid" id="A0A6P8I5U6"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029426">
        <property type="entry name" value="FAM86_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14904">
        <property type="entry name" value="FAM86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAM86 N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563313.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41955" checksum="B950E3382065FE6A" modified="2020-12-02" version="1">MAANMKTEEQEQQEILFSIQKQYFQMVPIKFFDWKNIAQYLDSTLQKVILRKTYMSNEFVKYTPSIRYKRMFLKQLMKISEEANHELVDELYECYAEVISEVDDDQSPCYKTYILPSGSGIIVEESQNIISQGTTGLSTWQAALYMLEWVLENSKEFENRNVVELGCGLGLLGLSICMSYSPQHYVFTDCHEAVLGKLNKNLSINGFQRNADSNCYCGTEDETVLPKCPRINKRNKLIGSNWTFDLAMNNGCNDRCVPEYFREELQYSDSREQETVCYTCQKCSKCYRPLSTLQALGKDCESHDNVKTNCTKRVQLEKKDLYRKESRDRDKVNVASIRLDWEDVSMDDLEGLSCGVIVATGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7Y0</accession>
    <name>A0A6P8I7Y0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116297148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116297148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561172.1">
        <property type="nucleotide sequence ID" value="XM_031705312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7Y0"/>
    <dbReference type="GeneID" id="116297148"/>
    <dbReference type="KEGG" id="aten:116297148"/>
    <dbReference type="InParanoid" id="A0A6P8I7Y0"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031561172.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15312" checksum="048B487E4C4191DA" modified="2020-12-02" version="1">MALDEATVWITRLTVTVQHIEIWQNIKELKRRCQIPGYGLQFYIYNIAILPTVELSDPTTSWSSVLQYQFFLVNTIQGKALSRSIISIFVQGKEGTRWMMSALREKELELSSVRKKFKQEVKNKISSASKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAS2</accession>
    <name>A0A6P8IAS2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain collagen C4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562347.1">
        <property type="nucleotide sequence ID" value="XM_031706487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAS2"/>
    <dbReference type="GeneID" id="116298119"/>
    <dbReference type="KEGG" id="aten:116298119"/>
    <dbReference type="InParanoid" id="A0A6P8IAS2"/>
    <dbReference type="OrthoDB" id="6086925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028169859" evidence="2">
        <location>
            <begin position="27"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562347.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32494" checksum="448DD9103138F690" modified="2020-12-02" version="1">MQFGNESWCKVALLLAVSLTVLSAHGQEQTVEKRGQGRKTPTTLTDVIKVLMEFEKRFKRIESRHMEVIRGRDGRDGLPGKPGQDGRDGSPGPRGPRGLKGARGNHGVRGPPGPKSGGVQYVRWGRTTCPSGASLLYRGRIGGENHAHKGGGANYVCLPETPKYGRYKNGHQNAGYMYGTEYEVNTYNPFTKGHLHDHEAPCAVCYVTKRSAKMMIPATYECPAGWTREYHGYLMSAYHNHPHPTQYICVDNDAEGVPGTHANLNGALLYPVEGVCGSLPCHPYVTGRELTCAVCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAW1</accession>
    <name>A0A6P8IAW1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 263</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116300578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP263 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565323.1">
        <property type="nucleotide sequence ID" value="XM_031709463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAW1"/>
    <dbReference type="FunCoup" id="A0A6P8IAW1">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="GeneID" id="116300578"/>
    <dbReference type="KEGG" id="aten:116300578"/>
    <dbReference type="InParanoid" id="A0A6P8IAW1"/>
    <dbReference type="OrthoDB" id="10259713at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="9">
        <location>
            <begin position="184"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031565323.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="44643" checksum="75C7A2E2A910587C" modified="2020-12-02" version="1">MAASSDVDVSSSLDQEEDPLTELTDQELYNLVQETIHANEVLRNETSMFEKFLKRVDPKDLGMQSSAPTTVQPTIETPHRGLKKRSRSRGPSLDRHLKLSAEQKCDIAQRELEELRDEIQKLGDESEKILDNYKAIMEEGEIRTAEIKKTSYEFERDIVKGAINQRTNKVIAERVTRYFEDKLRSRDTLIEKLRLKNSTLKVQKRKLHMQLKQKEEMGEVLHEVDFNQLKIENQQYLEKIDEKNQDLLRLKLMTGNVQQILNTYKKKLHTLTMESDRLKTEILQRNELLYKIDAENHLVDKDKSTSEKLNAKLKQQLTDYKVPDVMDYVGERAKLYELNKVVKMWQRKVEIAEMALQTNKKTWHKLLVSAQDDMNQWLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB11</accession>
    <name>A0A6P8IB11_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116298259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562507.1">
        <property type="nucleotide sequence ID" value="XM_031706647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IB11"/>
    <dbReference type="GeneID" id="116298259"/>
    <dbReference type="KEGG" id="aten:116298259"/>
    <dbReference type="InParanoid" id="A0A6P8IB11"/>
    <dbReference type="OrthoDB" id="5947432at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="entry name" value="Schlafen, AAA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029684">
        <property type="entry name" value="Schlafen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155:SF30">
        <property type="entry name" value="PROTEIN SLFN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12155">
        <property type="entry name" value="SCHLAFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="SLFN_AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schlafen AlbA-2" evidence="1">
        <location>
            <begin position="171"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562507.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="81787" checksum="4F43A3F298878F18" modified="2020-12-02" version="1">MAASGLQSENCRTLIVIQISPHAVQNRNKKSGIIQETCSTICALLNSHEGGNLKLSSTQALTPNLLDELVRAIEQSLIEFLGLTNLRELCEVRITGRGKEIIFFVKPSDRIFTVNYNLALPTNFLVREVLRSEPLVNIARLLETGPLINSNLQSFIKEFLKDATIPGDLRESDTVQFKKVKSDRNKNKSLADRIISNKITHYISAFANHKGGHVYIGVDDETYSVLGENLDDKEKNRITERLESAIKNMLWPEEHGIPELGRHWNISFVPVCAGDSMTEIPGLYVIVISISACPGGVFLNHPETYIIENCKVAKMEFKRWKKRVLHDAHMQDIVKFCRENSWSESHSRFPTTTPERCQGNEPGYKDTEEHVQPMNLVVECTSIPKVISRVIPRNTKSKTMCVRITDVMEKHIQDGDFEKVQTFASKICFKSEAFHKPDIEVATRFMLALGAYRRRSFTEAYQELNKASALVTSAENSKEFEIQRLHLLACFLRGQGNHGKSYEVTCGGLQELESISPGWHSAWTLSDAGYLFSILAGEERNKEVRQSLKRQAVNLYIQAIEHTKKFGEDSNDTCKALTAKSNLMHRCHLRLAMLFLGCAPFAEKDDDFRDVTDEDMNNAVVNILVVEESVLKGDSLTEVNECYLSLAKSDINYRRSRINVEQGENYHKKAVEWATKARTLAENDQFPGILKYAQSRLDRLSTARRYSSVEEELLADLDKSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBI4</accession>
    <name>A0A6P8IBI4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tolloid-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116297985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562170.1">
        <property type="nucleotide sequence ID" value="XM_031706310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBI4"/>
    <dbReference type="GeneID" id="116297985"/>
    <dbReference type="KEGG" id="aten:116297985"/>
    <dbReference type="InParanoid" id="A0A6P8IBI4"/>
    <dbReference type="OrthoDB" id="5964477at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000003">
        <property type="entry name" value="Neuropilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028012063" evidence="7">
        <location>
            <begin position="26"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="306"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="431"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="8">
        <location>
            <begin position="565"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031562170.1"/>
        </source>
    </evidence>
    <sequence length="723" mass="80114" checksum="732F0BC4F4DDD746" modified="2020-12-02" version="1">MERTGLSFLILCACSVVLLLEGVSAFKLGDNARCTLGNTSFALLAKPGFQSIIAFDTNRIYHNLTDDDNITCHWKITAPPGYFVKIKFAQFKGCNELYNCSYYYFEAREGRNESGPLLSKLCTSDQCLDADKIYSIGTDMFVKFYFKKTPINFHVTFLAGVYAVRHDSFCTADFTDDGNHNIIFKESQGMFNTPYSSLHHGYPRFTDCTWKIVAPPGYIVKVEFSSFSLIKVPDCELDFVELSDGAFHSGINLGKYCGTIASARTIYSITSGLTVHFVATAYYSKDPRDGFVARYQILKQKSSGPCTDSNPSNEMSGQGGTLLSPNYPFNYPSNKRCTWVITPLKGQHLQFSTLGFHLKPSTSYSCQDTDHLEVRRGTTAAGTLVGSFCGVNGPIVIYASDSLWVQFVSKQNSYKGFSASYESIANIPRICSPLNNASTNNDLQLSDHRGFLRSPYYPGNYPNKLQCTWKIKGLPGKRIKLTLNDIDLGPPSDTCQSDYLQIRNGMSGSSSLQGNYCKAKTNQVIYSEGNSMWIRFHSDSKATFKGFDASYEINELCDNFNSFDANNNIRLSGSSGNFSSPGYPSNYPKDLYCTWKITVPEGKVKLTFSHFDVTKKSSTCGSDDFVQVYNGIGTHDTIGIYCGENIPGPIYSKDNTMSVYFRTRTGVASGFKAQFSTAAQPTRLAIIGGVVGGVILLTIIGSLVFVFVVRKRRQGSVQHIRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBR5</accession>
    <name>A0A6P8IBR5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116298083 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562295.1">
        <property type="nucleotide sequence ID" value="XM_031706435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBR5"/>
    <dbReference type="GeneID" id="116298083"/>
    <dbReference type="KEGG" id="aten:116298083"/>
    <dbReference type="InParanoid" id="A0A6P8IBR5"/>
    <dbReference type="OrthoDB" id="5985094at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049304">
        <property type="entry name" value="Gly_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21722">
        <property type="entry name" value="Gly_rich_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="252"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="7">
        <location>
            <begin position="548"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="717"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562295.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="97736" checksum="A3E71A939442988F" modified="2020-12-02" version="1">MEFRRNFVFGVWLMVLYGYCGCYSSLYYSSTSQDLPRTYLFNKSSTFTIPGTTHRLRVLLVGGGGYGCRGNAPGKAGRAGKVKVVIIDNIYLKNRTLEVKVGKGGKFPRSFAPGKDDTSKESSFISYRAEGGKNCDYIASSFSTDTRCFEHFKISHVTPAKDVKSINISACQIQSPTVLLSGDGGVLIDNNGPSAMPGKSNRSSAGGIGYGAGGGSGGNHKTSEEGCDLVDGGDGAPGVVYIEVVPKVCRKPVSVLFAIAYSSNSSFTSQKKTIQNIIKLIPQRKVGVLTFKDKTFQKVKLREYNDNQQLFSAITNLKNAYSTEIINFTNVYSEAILAFREEEASRNKANLKVSFSKTLVMFTHSWKKHVRRSQLLSLKKELKLLGVKIILVGLDEDLTDVQLREMVNDDDFVYTSDGDDYDLVLPMKEPYIIDTICRDPLYFHNLTGTPTKSITTNRVPSTSSREKNANGLQKDFEFLLNYDMKKVNIKNTTEIERVMNIADNLILNSHRIPNNTKTAPGLKVIQFLENFGLQMASTVASFADGDSGPRNFNTKHLGLTVATVNLISTTSIDLSNALNKGHVIVPKDAFQGNGRGTVVMLSSNPVASMKKENGTVITSQLVSININPKSPDVFKKPVEITFDINQDLLDGKRASCEFWEQKKREDFPHGFWSPEGCKIVSKDDASVTCHCNHLTSFAVLTRVHVDETPSENHARYLTIITYVGCSLSMLGCLLTIIIHAVLPSLRTERAFIHINLVTAIFLGQGFFFIAALLEGPRAMCYFTAVALYFFYLSVFTWMLVEGLHIYCLVIRVFHSGHERKRLYTAIGWLLPLIITVVCASAFRGDFVSNKLCWLSVESGAIWAFVGPAIAIIAVKYTSIELVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBT0</accession>
    <name>A0A6P8IBT0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116298634</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563017.1">
        <property type="nucleotide sequence ID" value="XM_031707157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBT0"/>
    <dbReference type="GeneID" id="116298634"/>
    <dbReference type="KEGG" id="aten:116298634"/>
    <dbReference type="InParanoid" id="A0A6P8IBT0"/>
    <dbReference type="OrthoDB" id="5988039at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031563017.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48837" checksum="D5E46248537A27E1" modified="2020-12-02" version="1">MANMASLSSSICGVTSESLDPQKNCFIFCCDDDKKPENEKDKYFVSSTISEVVDMIMDAVGEKKGLRELFLPETYDRLLKSMRVPDWVLLYFKLQTKLPDDAWQTLLNLTHLGRSGNSLDNAVLLTKNQIKAIKKMIFNIIKSTLKITELETDFPSCGVDLNSVLIWAIREQRLYGADTPHMEFNIKIDGRPLGGKDQIAVGIVPIDFAKKSPESALSVYPVAIANCKEERSNMKQLIGMLNKQKNWLKQHGLCVDGKSYNFKFTVTLDYKALLLLIHKKDDESFTLGGKGYGVEFCVFCDAVRACTHHGEIPNHACVDCLRSKANIARPTGVRDDLTFLLEEDLSNINLCSLHCEMRNMEQLLGSLGLFSHRVGTLDQLNNILSQYGPENTRGRTRIQVKEKPGQQTAVGRHNIKVASFSGCTERQFLDNAENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICC0</accession>
    <name>A0A6P8ICC0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116300432</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565171.1">
        <property type="nucleotide sequence ID" value="XM_031709311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICC0"/>
    <dbReference type="GeneID" id="116300432"/>
    <dbReference type="KEGG" id="aten:116300432"/>
    <dbReference type="InParanoid" id="A0A6P8ICC0"/>
    <dbReference type="OrthoDB" id="9925451at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565171.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26073" checksum="CF08464CE5FA6CF7" modified="2020-12-02" version="1">MRNKQCASVNFAANSNVDQKFLCQLLKIDGGIKLKSPTQQSTEYHHYYKNPCADNPCQNSGTCYITDKYDFNCACSEPYSGKLCEKVSWIRVSQEPLCFGAKDNSFGTFFAPSPGRLASIKLVHLNGTVTCDKSAQPTRSTFWGCFSPSTNISKITIIITDKNNSKLLPTYSNNLKGFHGNATAIVFSTENLGVFNEVTAGQEFRIWYYEDFTNNGESDNDGLSCANVYVVYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID74</accession>
    <name>A0A6P8ID74_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein F13E9.13, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564002.1">
        <property type="nucleotide sequence ID" value="XM_031708142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID74"/>
    <dbReference type="GeneID" id="116299483"/>
    <dbReference type="KEGG" id="aten:116299483"/>
    <dbReference type="InParanoid" id="A0A6P8ID74"/>
    <dbReference type="OrthoDB" id="10045006at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381:SF3">
        <property type="entry name" value="SGC REGION PROTEIN SGCQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="ZGC:162297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564002.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="29899" checksum="E8147E25B589486D" modified="2020-12-02" version="1">MVASRLVPKFTSLFSRQSAAIIGMIHVDALPGTPMNKLPMTEIVDKAKHEALIYKKAGLDAVMVENMHDLPYLNRQVGPEITAAMSVICNEVKREVGSTPCGIQILSGANKDALAVAKATGLDFIRAEGFVFSHIGDEGLVNSDAGELLRYRIHINAENVLVFTDIKKKHSSHAITNDVDILETAKAAEFFHSDGVVITGISTGSPASYKEMLAVHDAVSVPIIIGSGVDISNVDQYLSANAMIIGSHFKEDGHWSKPVSFDRVKSFMAKVEQIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDN8</accession>
    <name>A0A6P8IDN8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Glutamyl aminopeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116299876</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564452.1">
        <property type="nucleotide sequence ID" value="XM_031708592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDN8"/>
    <dbReference type="FunCoup" id="A0A6P8IDN8">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="GeneID" id="116299876"/>
    <dbReference type="KEGG" id="aten:116299876"/>
    <dbReference type="InParanoid" id="A0A6P8IDN8"/>
    <dbReference type="OrthoDB" id="6018855at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000003">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="23">
        <location>
            <begin position="139"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="21">
        <location>
            <begin position="364"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="22">
        <location>
            <begin position="666"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="18">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031564452.1"/>
        </source>
    </evidence>
    <sequence length="1081" mass="126060" checksum="9FB217138DABF1E1" modified="2020-12-02" version="1">MDEGYSPDNEGWGSSSDSFEDIDNVALLPEIKRKPNRIRRRKVRFLRDRSFEFSIRRMCSRRTLVYTTITAVLLVSVVLISIFVKPSTSEEFEETKPEKRSQFQDEPEKNQERKGKKLYLDNEGKKFAWQDIRLPTNLVPQKYRVELHPNITTFKFTGTVDMLLKCVKNTDKIFFHAKTMELTNIKVAKIKENADKLEVLSIKKITSSKDLEMHAIQVNDELQADQEYIVFVQFKASLSEKLFGFYKSSYKNKRGEIRYLATTHFEPTDARAAFPCLDEPALKAKFEMILIRDQHYTALSNMPLKKTVKRKDGLLKDYFKETVKMSTYLIAFVVCDFKHLSDRTKSGTLVRVWAPPDDIEQARFALSEAKKILYYYEDFFQVKFPLPKQDLIAIPDFAAGAMENWGLITYRSTSLLYDEKESSDSNKQWVATVVAHELAHQWFGNLVTMKWWNDLWLNEGFASFIENIGANYTNPEWKMMDQFLLDKTQLSMNLDQMSNSHPISVRVDNPNQINSLFDSISYDKGAAIIRMLKNFIGDTAFQHGLQNYLQAHEFSNAETKDLWSMLSKAAKDVNADARDVKEVMDTWTLQMGFPVVTIKRHNGKAAASQKHFLVHPKAKVTRKSKFGYKWLIPLTYRTQKNEDRKQVWMNKDNNEVSFDWPEDSGWLKVNYGQQGFYRVNYEKENWEKLKNQLNTDHKVFGGADKAGLIDDAFNLARAGQLKLTTALDLTLYLVNEKEYVPWSSALNNLGYIDSMLCASKGDYAYYKKYVLQQLTPIVEELGWEDKGSHLQKYLRASVLRLGSEYGHKKATKEAKKMFDEWRRTGKRISPNLRNVVYAIGVREGGEEEFDYMLKEYLSATVASEKRKLMYALTTTKKVSLLDRLLKMSLDRTKFRSQDTVAVITSVAGNCVARQKAWDFVQSNWDELYKRYATGSFDFSRLILRTSSHFSTKEMYKKVKAFFDNHDMASAVRASKQSLESIQANVDWSNQNRHDAINWFKAHTKQVKFEDLEERMTGMEDLIPEEYPGHNDYREEPEYSNERQFARNYYYPSQEDFQNDEEYFRDTREVVNENELGYGRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEI6</accession>
    <name>A0A6P8IEI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Trissin receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565297.1">
        <property type="nucleotide sequence ID" value="XM_031709437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEI6"/>
    <dbReference type="GeneID" id="116300552"/>
    <dbReference type="KEGG" id="aten:116300552"/>
    <dbReference type="InParanoid" id="A0A6P8IEI6"/>
    <dbReference type="OrthoDB" id="5968851at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565297.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34004" checksum="AE8BFF9076E59E4E" modified="2020-12-02" version="1">MNTKVIIAGLIFGVPIILFGIIGNCLVVIAVSKKRSLRSTTNYLLVNLAISDVTCLIFSLMAVFAEYIPLTSGTLADIMCKFFLSYNVPAMASIVSILTLTVLAVERYHAVVKPMKRWMRLKANTIKYAFCAIWLTGILFTLPMFINGYYKETSKSCRQYLYWNRLGYLTYQVSIIGSVVFISFAVIVVCYFHIVRNLYFRKKNVNFGEHSVAERLRNQRKRHVVKLSLSVTLVFVVFLLPFGILMILKFFNERAYRSYYEIAAILFFLEAGINPFLYAFQSTNFRQAFKQILKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFV9</accession>
    <name>A0A6P8IFV9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fibropellin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565640.1">
        <property type="nucleotide sequence ID" value="XM_031709780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFV9"/>
    <dbReference type="GeneID" id="116300824"/>
    <dbReference type="KEGG" id="aten:116300824"/>
    <dbReference type="InParanoid" id="A0A6P8IFV9"/>
    <dbReference type="OrthoDB" id="5946640at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565640.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35601" checksum="C92EEB338536B8AA" modified="2020-12-02" version="1">MIVAPLNKDVCVPNPCINGGTCKREVLIHPGHIHVSAEFTCVCPPGFAPPDCRNKTDDPCVPNPCLNGGKCQKDPSSTNGYICKCLGPHFVPPKCRCDCPQGDPSQKPPILASKCDLAGECVCPVGYTFQAGVGCKSGRQNPCFEKPCLNNGTCVPEGDKYRCICTENCKGNICQTCDFCPPDYCFNGGTCYSVGHKPYCRCRNEFLPPRCLFKKPVQKVYHCHPNPCHNGGKCIERVNGFDCQCVPPFDGPHCEHDKCMDCDVHALCIHGQCKCRRGFRGSGYKGDCIKESVCPICPVNAMCVDNGCECVPGFMLVKQKCIPVMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH27</accession>
    <name>A0A6P8IH27_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116301183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031566061.1">
        <property type="nucleotide sequence ID" value="XM_031710201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH27"/>
    <dbReference type="GeneID" id="116301183"/>
    <dbReference type="KEGG" id="aten:116301183"/>
    <dbReference type="InParanoid" id="A0A6P8IH27"/>
    <dbReference type="OrthoDB" id="5969257at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000114">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF893">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028520849" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="11">
        <location>
            <begin position="70"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="483"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566061.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="70787" checksum="829006406661149C" modified="2020-12-02" version="1">MVRSLCFFVLLPVVLSQVQQGPIGAGQIPDDLLKSPESHSHLFHGDIKLTPAQELNMERYGNPYGTPLGRAASSVDKERWPNAVIPYEFDCSIANMESAITSVKRAMAEWEAKTCIRFKPKTTETAFLQFFRGQGCWGHVGHTANYMSQISIGDNCDFHHVMTHEIGHSVGFWHEQSRPDRDNSIQVLWENVLPGLEDAFAKRSWGTEVIDYGSKYDFASIMHYPFTAFSKNGKPTIRAIADMQGKTPYVELSPDDAMQTNAMYKCDAVMRKRMADDFEANFKPLPRIVKRSNTCSDKSANCQSYKDSGLCNAHADSLIYWCPVTCDMCSSDSCMDKKGNCKAWVAGGHCQTNPEALKIDCPYSCNFCGNPTTQAPVITQAPVTVLPTTKHNCGTVGPTTQAPNTPPPPTQAPTPEPPTALPPTAQPPTPSQAVGLRCADKRSKCPTYAQQGECVKSGWVFRNCLISCKAKCDTQPLKPDGDCANALGLGWDFTLPDSAFTSSSTLTPGGGWSAPAHSARLYFEDDRNRKLIGGWCMTARDNNQWLKIDLGKEKKITGIATQGRDVFYEHVEKYELEFSRDGSSWTKYPKVFNGNCDHFTPVLNRFNTQVARYVRVLPYNLPNQYAWPCMRVELYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ30</accession>
    <name>A0A6P8IJ30_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tyramine receptor Ser-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116301809</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566787.1">
        <property type="nucleotide sequence ID" value="XM_031710927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJ30"/>
    <dbReference type="FunCoup" id="A0A6P8IJ30">
        <property type="interactions" value="997"/>
    </dbReference>
    <dbReference type="GeneID" id="116301809"/>
    <dbReference type="KEGG" id="aten:116301809"/>
    <dbReference type="InParanoid" id="A0A6P8IJ30"/>
    <dbReference type="OrthoDB" id="5959950at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="51"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031566787.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46337" checksum="B0A5A8F5EB954BFE" modified="2020-12-02" version="1">MAPASNDKTSVKLCPNCTESNNTVPINTTCAALCVVSVALYIVIMVVAAFGCIMIIYAFAWNKKIRKVVTTYFIVSLAVSDLFTAIVVMPFDVEQILTNYEMWRHGAFMCTVWTTLYLLMIPTSILNLLVLTVDRYKALSDPLNRFKESPFMTKRRALVIIACLWIYCLLFALVPHMGWKVYPDVIVHGQCVFNISPIYGMLSSVFNFFIPLVVMCGLYFKIYRIANSLHANLPAGQLASPSRSPHDTGVQDRRGVKSRSKKIKDQKMLLKNTRAAKTVLLIVFTFVLCWMPHTIYSFIVSGACDSCYHAEEGPILAAVFLIMGYANSALNPFLFGYHHRLFKKTFKIIINKVSVKFKCHRIPPPRHLPVRSPYRITNSGSVQMYNPSVDDISGNQNLGASLTSIKDVVDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJY6</accession>
    <name>A0A6P8IJY6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Dynein heavy chain 2, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116301988</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567025.1">
        <property type="nucleotide sequence ID" value="XM_031711165.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IJY6">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="116301988"/>
    <dbReference type="KEGG" id="aten:116301988"/>
    <dbReference type="InParanoid" id="A0A6P8IJY6"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000006">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000014">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000815">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000012">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF32">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="1868"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="2479"/>
            <end position="2626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1571"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="3084"/>
            <end position="3160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="3290"/>
            <end position="3352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="3604"/>
            <end position="3631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="3653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031567025.1"/>
        </source>
    </evidence>
    <sequence length="3653" mass="418381" checksum="705C6E4A5439F527" modified="2020-12-02" version="1">MDPEAQETGSVNLSTGDDNSDTNALESSQAVSEKHKNGSSSPSENGVDGERGAVDDHGSTGSGGKEFDPAEMISMIKERVTLSSLTSDLWTTEHDDTILKFINDPNLQVLVAYMDKLLGLQVSTSIPPHQVEELTYIIRSEAAILTAENLEKNLQFGTVHMNYVEGLLRLMSNLYGPLFFGKMNWPDSIKNDFSAQVHKFMANLTDTRYKMQGKTVLYVPNENTHLSKEAAAKSKEFVQRLETAMIHWTRQIKEVLSSQDNFETAENSGPLEEIEFWRSRCADLSGISEQLDKPGVMRIQSILELSKSSYVAPFLKLSKQIQNGSAQAQSNLKFLSILKAPCEDLAQAQPKDIPPMLPKILNSIRVIWVNSEHYNTAERLTGLLRKVSNEIIKRCSTKICLDDIFDGRIRISMLGLQESIECCEAWKEIYEKIRRMHAKLSGHLWILDQSSIFAQVDAFVQRCKDLLEVCEGQMHFARMYDGEKAPLPCFHGVRGPEIVRSLLEIEATFEKNLQILKAVKKTILDVKATTWHDDFNRFRAGVKDLEVMVQNLIASAFESVTTVQEGLEILDIFQHLSSREAIRRTIDKKTVEVFQLFNEELNLVKKEFNTKTVDLPAMYPKYAGSASWARMLRRRIDKPMEVLDKAFFLPQIGSGDEIRTQYQQLAQALDEFVRKTFNEWTATVDKESAKLLEIPLMKRNQERTGTLDLNFDKILLKLINEIHYWEKLMFETPHYVSEMYQKKEDLRILRENVLLVIRDYNRIIAVLSPEERSLFKERIRSLDKKIHPGLTKLTWASKGISDYFIGECRNNCSKVQGIVDDYKNANLLISKNCVKISEMLLVKIDGKRVYDNLEFEDEQKNHMSIIQTRLQVTHMDIVGTMKSTYEVFKNDGQEVQAHWLRYTEKIDRMVEEAFRLNVKWSLQELSRAINGDGKSIPNPLLRVKVVLEGDKVEFSPTLTKLASMMEHIASSLTTCLSIFKRLPDLLAKKKSSKEPVHIIIERDDETKKIQVSIKTGMSANASHLQSYLSTWDTYREIWEIQKDAFIRRYQRLNPPVSSFDADIARYTEIANNFQKEETVLNIDFVMLDCSPLKFALLSHCNEWQSKFTTLLREMASQKLIELHNFLKENAKKLSAPPENLDELGESLALLERLQNDLKNIEAKFPPLHEQFLILEKYEVPIPEEVQEMLDQLSGEWVSFQQCLIDSDIMLKKSKEKFKTGLIISSEEFKKTVGGLFEEFQTKGPFSSAIAVKDALDQVKQYHEQVHSLKNQETTLRRGLNIFKIEQAPSKDLQGLEKDLEHLEQIWSITSEWEGLWDTWKGGRFTELVTTDMEMTSQTLFKRLNKTIREVKDKNWDICDSIKSRIEQFKRTMPLIQDLKNPAMRERHWNQIKGEVQKPFDQNADDFTLEKIIELGLDQFVDNISDISGAASKELSIEQAIAGIAQAWEQINLDIGPYKDRGHFKLKATDDVFQQLEDNQVTLSTMKASRYVKAFEAEVDKWERTLSLILEVIEMILTVQRQWMYLENIFLGEDIRKQLPRESAEFDDVNAHWKVIMQRLNKDPNALRGTHHEGLLERLNEMNTKLEEIQKSLDMYLETKRQIFPRFYFLSNDDLLEILGQSKNPEAVQAHLKKCFDNIRSLKMAKMGITQKTEAVGMYSADGEYVEFGHSVLLEGPVEAWLCDVERSMRWTLKELLKHCRLALKKNLSKRDKWIKEWAGQLTITSSQIQWTSDCNKALSSTKERGDKKALKSFKKKQVSMLNKFSEMIRGNLTKLQRLKIVALVTIEVHGRDVIEKLIKSGCSNVSAFEWLSQLRLYWDKDIDDCVVRQTNTQFQYGYEYLGNSGRLVITPLTDRCYMTLTTALHLHRGGSPKGPAGTGKTETVKDLGKALGNYVIVVNCSEGLDFKSMGRMYSGLAQTGAWGCFDEFNRINIEVLSVVAQQILSILSALSAGATRFVFEGREINLVWSCGIFITMNPGYAGRTELPDNLKSMFRPISMCVPDSGMIAEIILFGEGFNNTKILAKKVYTLYSLAVQQLSKQDHYDFGLRALTSVLRYAGRKKRANPDMSDEEILLMSMKDMNVAKLTSQDAPLFNGIVSDLFPGVEAPVIDYGKLRSAIEKELKEAGLQVTPSSLLKVIQLYETKNSRHSTMIVGQTGSGKSVCWKILQSAMTRLKRDGESGYNVVREFPINPKALSLGELYGEFDLNTNEWTDGVLSSVMRQTCADEKSDEKWILFDSPVDTLWIESMNSVMDDNKVLTLINGERISMPEQVSLLFEVENLAVASPATVSRCGMVYTDYKDLGWQPYVDSWLERRTDRSSIEHLQRLFEKFVPKVLEFRRRNCKEPIPTSELNSVASLCILFDALATEANGVVSHDESYVRMIELWFLFSLIWSICASVDEESRKKMDNFLRELEGQFPAKDTVYEYHVDIKQKTWASWEDKLRAGWRYNPSVPFYKIMVPTVDTVRYDFLVYNLIQAKQPVLLVGPVGTGKTSVVQKVLQRLDPKIYSLLVINMSAQTTSNNVQDIIESKVEKRTKGIYVPIGGKQMITFMDDFNMPAKDTFGSQPPLELMKLWLDYGFWYDRTKQTIKHVKDMHLLAAMGPPGGGRMVISKRLQSRFNLINMTFPQESQIKRIFGTMINQKLQDFEEDVKALGDIMTQATIDIYNTIVAKMLPTPTKIHYLFNLRDISKIFQGLLRANKDLHDTKTSISRLWVHENFRVFADRLVDTQDRESFVSLLSDKLGSMFDLTYHNLCPNKLPPIFGDFMKDGSVYEDLTDFKALKKFMEDQLEDYSMEPGVIPMDLVLFRDAIEHVTRIIRVIGQPRGNMLLIGIGGSGRQSLTRLASYIIEYKVFQIEVTKHYRIIEFRDDIKRLYYMAGVENKPTVFLFTDTQVLEETFLEDINNILSSGEVPNLYKPDEFEEVRTALSDSARKDGIADTPESMFAYFIERVRNNLHIVLCMSPVGDPFRNRIRMYPAFVNCTTIDWFSEWPQDALLEVAEKYLEHIDVGDDELKPAVAEVFVVVHRSVVDMSSRMMLEVKRHNYVTPTNYLELVSGYQTLLKEKKKELGDAASKLRNGLEKIDDTRAKVEVMSVELEEATLKVNEFQKQCEEYLVVIVQQKRDADEQQKIVQARSEKIAEEEEKCRSMAENAQKDLDEAIPALQEAMKALESLNKKDMTEIKSYGRPPALVEKVMEAVMILRGAEPTWAEAKRQLGDGNFIKQLVNYDKDNMTDRVLKKIGTYCSQSDFQPEIIGRVSLAAKSLCMWVRAMEVYGRIYRVVEPKRQRLNQATQQLAEKQAILADAKAKLKEVTDRMEELKRQYDEKSAQKEELRKKAEMLEIKLDRAGKLVSGLAGERDRWEASVSILDENIGYLVGDCLIAAAFLSYAGPFLSNYRDELVEKTWLAQVRQCNLPCNPNFSFSLFLAKPTTVREWNIQGLPSDAFSTENGVIVTRGNRWPLMIDPQGQALKWIKNMETKKGLNIIDLQQHDYLRTLENAVQFGNPVLLQNVQEELDPSLAPILNKSLIKVGGRYLIKLGDKEVEYSPDFRFYITTKLSNPHYTPEISTKTTIVNFAVKEQGLEAQLLGIVVRKERPELEEQKDSLVINIAAGKKKLEELEDEILRLLQTAQGSLLDDEQLVNTLNSSKITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKI1</accession>
    <name>A0A6P8IKI1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302178</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031567262.1">
        <property type="nucleotide sequence ID" value="XM_031711402.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IKI1">
        <property type="interactions" value="1068"/>
    </dbReference>
    <dbReference type="GeneID" id="116302178"/>
    <dbReference type="KEGG" id="aten:116302178"/>
    <dbReference type="InParanoid" id="A0A6P8IKI1"/>
    <dbReference type="OrthoDB" id="165498at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17101">
        <property type="entry name" value="FERM_F1_PTPN13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06792">
        <property type="entry name" value="PDZ2-PTPN13_FRMPD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052074">
        <property type="entry name" value="NonRcpt_TyrProt_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900:SF2">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KIND" evidence="17">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="15">
        <location>
            <begin position="561"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="1038"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="1327"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="1435"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="1963"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="2058"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="2192"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="2600"/>
            <end position="2855"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="2773"/>
            <end position="2846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="966"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1593"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1742"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2154"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2276"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2343"/>
            <end position="2459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2477"/>
            <end position="2544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1134"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1160"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1172"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1200"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1253"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1285"/>
            <end position="1303"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1593"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1644"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1679"/>
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    </feature>
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        <location>
            <begin position="1695"/>
            <end position="1705"/>
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        <location>
            <begin position="1746"/>
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    </feature>
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        <location>
            <begin position="1790"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1827"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1853"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2161"/>
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        </location>
    </feature>
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        <location>
            <begin position="2285"/>
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        <location>
            <begin position="2297"/>
            <end position="2308"/>
        </location>
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        <location>
            <begin position="2343"/>
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    </feature>
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        <location>
            <begin position="2421"/>
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            <begin position="2484"/>
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        <location>
            <begin position="2520"/>
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            <begin position="2531"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567262.1"/>
        </source>
    </evidence>
    <sequence length="2861" mass="316571" checksum="4EC5D19292A859D8" modified="2020-12-02" version="1">MPALTANTVTLEEVLEVRGGPLTEEELWAVLAQSCEALQDVFQRGKARNRFFGSYSITPEMILLCHTGRVKFSLDQGYHFDRSYTAPETYANRATPSDTALEKICVYSLGMSLYHAAEFEVAVGKPISLNESLESVLLGMCEESAHARSGLSQVMQECQSHYSRRNYRDTVASLVESLLGDEIPDIEVHDSLYDMEAGNSTDISDYDISEENYPSRFSPVLATPRSLPSPPSLQTSSRGQSTSAQLVGSNHRRVLTPPITQRSASPGLNKSRPIPPTLEKYRSVLENARSKRSMAASLNGLDQLHTRESSPSWDQMTPHHPINRSEPRLDTPSVGYQKIPEASGYYPHPPAEGSQYERPTSHLSGDIQNRSGPSGTRPDIQGLNRFASMHSVASDSSSSASGPRSSMFSDGRSSSAVSITQGSYAPESYLTDGYESEFNLKSFGSSVSQNAFRAGRNIPSLSNNPLYLSVNDLHQPSAGLGSSLSGPLAADNRYHSLPNINRFNDIEKEKHDSEDTLKTFFGPEFVMITEDPEKSIVNITPVGQLRKDGQKKGFHSSHPRKIVTVVALNGQKLQLMAEVSMTTKDLFEQVTRFLGITEKIFFGLAKIEDDEVIFLDLDVKLSKYAPSKWKESKGEMVEFILYLRVKFYVEHTELLSLETTRHQFYLQLRKDILEGRLYCHEEAAFLLAGLALQAETGNYVDTLEGDYFLVEHYLNERIIKKLSVENTTLQLPEFHKNFAGLSEEQAELEFIQEAQKLPEYGIHFYKVQYSKKSDNSEKLYLGICVRGVTIYESRGHIKSPVHKHSWPMTKKLSFKKKKFLIEPMSNPDGVKLTFYTNHYKKAKYLLQMCTAFHRFQMKMRTRLASIKHEMSVDIDIENKHQAVDGPSKDKLYDRTPAPPIYKQNSLHTPLPRSVSTEYREISVDLPEEKYHAMPRSMSVEHNQEEPDTDEYHLPRSVSMQYSVDENHNKDYHGNQEPIGKHGKHDDLSPYVIDSTLNVPSKQENQQDDTKHLLSPKSPDGEIPNSRDILSSPDREIRVIKFTKEPGKGLGITVLGGENSKRLDRGIYVKSVTEGGAAARDGRLKAGDRILAVNGNSLEQVTHERAVTLLKTISSTVELVVSQSPHNVSALDLSNIPTAGSSNEEPQTLEVKPLITPPQQENRHLSRTRVESPCSSDTLSPTDSHPSTFNFPSEDEPVTMISKSISSLATPQSSSHSVPSKDRNSSSNYLTVSPPEKAGKTDSDEIPEPVTMATLESPNVTGSPSMGVRRDSKSPSTPYGKLSSREVLQSDISNDSQSSFTAGSVGSERSIEHGNSVDSDDLPDKSFTVELEKIDKSLGLSVTGGINTTVKLGGIYVKSLMLNGPADRDGQIRIGDRILAVDGISLVGVTHKQAVEIIRRAPQRCKIVLDRSVHVNVPASIKKNSSRTQAKDKPFVVELVKGIGGLGLSLVGGRDAGPEHGGLLRIKKMFPGQPAALSKKLALGDIVLEVNEKSLQNASHQDAINMIRHEPSVVRLLVKRDPYSIPEVLLSRAASNASDVDPVQLLNDIQNKLRSQTTSPVSSPPQEPQPNNIEQKLAEAAGEIRDLRDKREERVTYESDRTLQHQLSDPSALMAKQREHEPVTTSRSLPGKLSLKSRYFDNTPSEDKESVRKKEERDESEPDKPPYIDRKSSDSAVGESEQRRPDRRAADKISSESDLPSLLQQIRSEDSLNRIMSPQAPLAEYEESDLDIDEGIMINVDDGVAVKIDDDEHPTDSQDDVDDGSGGVNAITKAPGTSYPVRSEHDISLDVNDDESDDDTADNEDDSDDDSMNKVLATTVTPPKETSDTSDIDDDNAEDIDAVLELLSGSRTQHKPEELNQDNQEHSSSDDDDSEVNLNINEDLNESDNYLEPIQKNSTEPQMEERNDRPLYMVNNQPGPTWSEESLSEKLESLEETIVESTPDLTKISAQEEASLTPKEQLITVELEKGSGGLGFTLAGGADTMGGCFVRDVIGDPAKADGRLQKGDQILQVDDTDIRSMKHMEAVNVLRATKKFVKLVVVRRPTMVVKDGTSGHLETVNLTRTSRGRIGLLLKEDDQGVILVDDVVPGEPAAVEGNLKHGDVIVEIGGRKVEGIGFLAARQYLDAARPVVQLLVKRTNRAAVSKYTMGGSLEQGYSFSEDLPEENVDSGAESTDEEQDVEDVEEPKDDVFNVKLEKGPRGFGFSLVAAPSTEPNVQGIFIKTISAGSVAEKDGRLKVGDQLLKVNDEDVYGLSHARVIGMLRKVTTTVSLEIRRPGGAVTQTSSKEHKDNIKISDSKNSSPLSNSLDLDITLEDKEESLTGSSEVKDEDEIIDLLNAISESNKEFNSPSKNKQPKPTLHKRDTDSVLSSILSSIAAPPSPTTPRSNDLNDADSINSDSDAESLTGQENYTIDDSRAEYSTGDSLQRLSSGSYESKHLSDSSNNKSNGKTQSFDSSDSDYEDINVFDMLQDNSKMGMNRDIGNIDSNNTELNGTISDVPPPVPTTSIPLGDDEDLPAPPPRKESLLKSSDDGWSSSGDSDYSSKRKVNGFVTLHSSSSEGDMASKASGPLIDVTSGGRYTGHKLKMLIGALQSKIESNVMADEFKALREIKPTDDCSVSKHPENKDKNRYRNVLPFNETRVHLSGEGNEDYINASHIRVPVGEDVYHYIATQGPLPNTTKDFWQMIWEQNVEVIVMPTLEREGGKVKCHRYWPESEDLVIPRKFRVTLLDKKMYDSFTERKFSLKHLGSGESIEVTHLKFTRWPDHGVPKCSFEMVQYVTYMRELTSSQAPIVVHCSAGIGRTGALITVDVCLGLMQRDLMFDVDKIIRNLREQRHGMIQTKDQYIFCYKACLEVLRSLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKM1</accession>
    <name>A0A6P8IKM1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibroblast growth factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566983.1">
        <property type="nucleotide sequence ID" value="XM_031711123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKM1"/>
    <dbReference type="GeneID" id="116301947"/>
    <dbReference type="KEGG" id="aten:116301947"/>
    <dbReference type="InParanoid" id="A0A6P8IKM1"/>
    <dbReference type="OrthoDB" id="5987799at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00058">
        <property type="entry name" value="beta-trefoil_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056378">
        <property type="entry name" value="Let-756-like_FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027877958" evidence="2">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566983.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24156" checksum="83BB05C0F5B0CC87" modified="2020-12-02" version="1">MVKNVHLVLLIVLVFYDPLIVSKKLRNKTGISSRFRNKTKNQATKVSYNKNTKWPSPRINNNWMRSTYITTKKPTNREHCKIFCRSGYHLQILPNGLVRGTVMQSSKHVLFEMQSFGPSLVKIKSVATGRYLSMRRDGSLRATRHSNSRETIFKETHEMNAFHSYASHKYYRETPHDMLVGIKRNGEVKRATRTMHGQTATQFLVIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILE0</accession>
    <name>A0A6P8ILE0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein Mis18-alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116302333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031567475.1">
        <property type="nucleotide sequence ID" value="XM_031711615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILE0"/>
    <dbReference type="FunCoup" id="A0A6P8ILE0">
        <property type="interactions" value="1685"/>
    </dbReference>
    <dbReference type="GeneID" id="116302333"/>
    <dbReference type="KEGG" id="aten:116302333"/>
    <dbReference type="InParanoid" id="A0A6P8ILE0"/>
    <dbReference type="OrthoDB" id="74210at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034752">
        <property type="entry name" value="Mis18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431:SF1">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51793">
        <property type="entry name" value="MIS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mis18" evidence="13">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031567475.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25465" checksum="B0D446775146022F" modified="2020-12-02" version="1">MAANSTEETTIEDNEAEETLPLVFQCTGCLSILGDSFAWVCADPNLRTVSLSAVTHGVHIATEDGMEISTEGDDLGSTFIPLQCTACQAKIGRIYKTTPRKLDMIRDIYTLDCSSIKSYQLGSQKAKNTFKSTEEILEIPTAQVLHSEIIKVQSVIVTLNERLQALESQLVTNETQVREQEKKRSTPERNIKRNLRNNSDSNLNLEALENGPTKQKRKRVFNRMSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILP5</accession>
    <name>A0A6P8ILP5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116302239</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031567328.1">
        <property type="nucleotide sequence ID" value="XM_031711468.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ILP5">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="GeneID" id="116302239"/>
    <dbReference type="KEGG" id="aten:116302239"/>
    <dbReference type="InParanoid" id="A0A6P8ILP5"/>
    <dbReference type="OrthoDB" id="5976751at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="232"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031567328.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="60572" checksum="9C8EE912DCB31730" modified="2020-12-02" version="1">MEVISSLNDSKNKEFASTSIQNILNENLYSPEQKTLNGIAIANFSFKESPPSPLNLKSVEIKATSVSLSWEPPKYHQVYSITGYRLQQRKVGRMQWVRGPVANQYTGKVEDLQPDTDYEVMVAARNEYGEMGSEIISVKTKADMTAIIVISVVIPVVLLVVLIIGFLVCWRQRRKRLQIEEQLALEQINRNDLAKIKAMEMTEYLHFSPETIVGLENELFAKKWKEIPRDCVEFIGELGSGAFGEVKKGKLISEEKSSYCAIKMLKAQATQIELRDLVNELNIMASVGEHPNIVHLIGACSIDGPLWLILRLAENGSLINYLQSHRPEDFHEYEDDIDSAANVGIPCMEKIKFALGIAKGMNHLAEKRCVHRDLAARNVLLDLYNNPMVSDFGLSRDVYESGQYEKTSMGKLPVKWMAMESLDDMIFTVKSDVWSFGVVIWEIETLGKLPYPGLNGMELLLQLKNGFRLYKTKDXLDEVYRIMEDCWKENPKDRPTFSELVERLTHLLEIYAEYLIIQSTKESNEENQESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMD3</accession>
    <name>A0A6P8IMD3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302740</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031567962.1">
        <property type="nucleotide sequence ID" value="XM_031712102.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IMD3">
        <property type="interactions" value="2035"/>
    </dbReference>
    <dbReference type="GeneID" id="116302740"/>
    <dbReference type="KEGG" id="aten:116302740"/>
    <dbReference type="InParanoid" id="A0A6P8IMD3"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="161"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567962.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51871" checksum="AE9E0F8129047320" modified="2020-12-02" version="1">MAEVNGEVXIEIIEGCRMPVRMSNSDEWPLAEIISKKEAKDGWEFYVHYIDFNKRLDEWVTEDRLDKTKIQLPKKEDSKKISKGAAGSRPPSPERDLVNGNGTRTKAVIGRKRKANAMDKSSDDIIIESQDSPTKDSPPKINNLRNHGSMVHDRSNDDIVTRMKNINMVQVGKFRIRPWYFSPYPPEFTRLPLIYLCEFCLKFVKSFTCLKRHMEKCTLFHPPGNEIYRNGTISFFEIDGRKNKLYAQNLCLLAKMFLDHKTLYYDTDPFLFYIMTERDSAGFHIVGFFSKEKESTEDYNVACILTLPQHQRKGYGKLLIEFSYELSKFEGKTGTPEKPLSDLGLLSYRSYWSQTILEILVDLKSEDGNPPSITINEICELTSIRKEDVVSTLQHLGLIHYYKGQYILSLNNEVLEGHKRAMAKRKIRIDSNCLHWTPKDWAKRGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INX3</accession>
    <name>A0A6P8INX3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303341</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568731.1">
        <property type="nucleotide sequence ID" value="XM_031712871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INX3"/>
    <dbReference type="GeneID" id="116303341"/>
    <dbReference type="KEGG" id="aten:116303341"/>
    <dbReference type="InParanoid" id="A0A6P8INX3"/>
    <dbReference type="OrthoDB" id="10071568at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568731.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="68721" checksum="131486C3CAFE7A9E" modified="2020-12-02" version="1">MADKISSINAKKFVSLLASRFKEDQQSIDNEELRSYFTDAVSNLPKSKVKTCLQKEFNVHFKHLSSILNVVPKIPKQHKDASQKTFKLNLYARDGLERAFEVLRECRSNEEKDRIYKSFQACFPYFTNTKKIFATVREVETSYDLSSVQKCIEMTIGCHTMKSILECLSSVLEEFSSKCDACINELESDAKTKRVKELQDSLHQNIVLMNNRWKASSDDILEGDDVTPKDSYEDLMAAMLSLYTDMQLVSSSINEESCVENLATLIFAVLGHSPEHCMDVFLQVTQLDCNSSAALIPLLRCILERNQGMLQTTQYIKFISLARIGLQLCSLASSSSSTKTKISILKVAEKQDAPASFVSLVSKHDRRLAERLKLSKKMTASQVTSHLLGEQREENMEALLDLASESGGESDQKPTEEHGPTDDAQGNHPTDQPLFFFDSAGGKEDEQEIERVEFEEHEVEDAILHRQLKTLIGQLEEQSDLEDEEITEDLFVIDKIPSEKSNQNDLKEADGDNDPTQSESTKDQRALNSVPSPLKRKRAAEVIDKEGETEVCHDEEEQNSSEIESKKKSKESKTFAVKAKRRSMIESTPVRMATRSSSRRAAKSYSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPH8</accession>
    <name>A0A6P8IPH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116302972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568268.1">
        <property type="nucleotide sequence ID" value="XM_031712408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPH8"/>
    <dbReference type="GeneID" id="116302972"/>
    <dbReference type="KEGG" id="aten:116302972"/>
    <dbReference type="InParanoid" id="A0A6P8IPH8"/>
    <dbReference type="OrthoDB" id="5954975at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568268.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31923" checksum="A3275B7839B377C8" modified="2020-12-02" version="1">MRKFNSKVKKRARKPQHSRARGHSQHNDESNLMVPESSIKNARIRSAIENGSRIPLPSDTKGLNLSKFEHVGKEGPLVVYAQDKKMFNEFGHFTVITSFKPSDSLRNQLFFASEPVSEPSKYENLTKSAEIKKDVRSKKDVIREATTTSANTRLLSQKARQTRRQPNSFEDLVKRYKDRQEKYFHSLGDESLYLFQKIDRMCKAGKREVDTNIPFQDEDSHDPKNNVKTTIQKKDKMVFPKIMAHKPGVKTVHIEIPKPQSNQVAFKDKTKNKLPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ47</accession>
    <name>A0A6P8IQ47_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116303750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031569201.1">
        <property type="nucleotide sequence ID" value="XM_031713341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQ47"/>
    <dbReference type="FunCoup" id="A0A6P8IQ47">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="GeneID" id="116303750"/>
    <dbReference type="KEGG" id="aten:116303750"/>
    <dbReference type="InParanoid" id="A0A6P8IQ47"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05272">
        <property type="entry name" value="TDH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569201.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40130" checksum="CD49625074D1BE35" modified="2020-12-02" version="1">MLSRYAKLSRYLCSTGNILLNRSFHKEVQTPRVLITGSLGQLGTGLARLLRDKYGRESVVMSDIAKAPPEVHEEGPYIYADVLDFQSLQSIVVNYDIDWVVHFSALLSAIGEQNVHQALQVNIHGFHNITEVCRKYNLRLFSPSTIGAFGPDTPRNPTPDLTIQRPKTIYGVSKVHMELLGEYYHHRYGLDFRSARFPGVISADSKPGGGTTDYAVNIFHEALRTGKYKCYLRKDTRMPMIYIPDCLRGTIELLEAPQEKLKLRTYNLGAISFTPEELAKEIKKFIPHFQIEYEPDERQLIADSWPEVLDDHNARLDWEWKHKYDLSDMVAHMMQLLAPKYLDVKTSTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQL3</accession>
    <name>A0A6P8IQL3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116303326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568715.1">
        <property type="nucleotide sequence ID" value="XM_031712855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQL3"/>
    <dbReference type="FunCoup" id="A0A6P8IQL3">
        <property type="interactions" value="1642"/>
    </dbReference>
    <dbReference type="GeneID" id="116303326"/>
    <dbReference type="KEGG" id="aten:116303326"/>
    <dbReference type="InParanoid" id="A0A6P8IQL3"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="138"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="234"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568715.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35510" checksum="B8E1A6EB8BB12F21" modified="2020-12-02" version="1">MSSVGESYNRGSLVAVPDPAKFYRKRLCASVGGGGSTKRHPVKAVLAGGIAGGLEICCTFPTEYVKTQIQLDEKAALPKYKGPIDCVSKTVKSHGVLGLYRGLSSLLYGSIPKASVRFSVFEYLKNTMSDENGKMTQVQTLAAGLGAGVSEAIIIVCPMETVKVKFIHDQTQSNPKYKGFFSGVRTILKTEGFSGVYKGVTATVIKQGTNQMIRFFVYSNLKSWLQGGDPRKDIGSIKTFIIGGIAGAASVFGNTPVDVVKTRMQGLEAQKYKNTLDCAIKIAKHEGPKAFYKGTVPRLGRVCFDVAFVFTIYENVMKLFDYVWVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISZ7</accession>
    <name>A0A6P8ISZ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570109.1">
        <property type="nucleotide sequence ID" value="XM_031714249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304510"/>
    <dbReference type="KEGG" id="aten:116304510"/>
    <dbReference type="InParanoid" id="A0A6P8ISZ7"/>
    <dbReference type="OrthoDB" id="5967017at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="81"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570109.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26557" checksum="C1A1B2966ED95B9C" modified="2020-12-02" version="1">MKNCLSKAIGRALLTFEELEEVLLDVETFMNNRPLCYLGEELEQPVITPNLLLRGQPARFLEDDADNFDDDRDKVTKRLLYLKTCRENVRKRWLTEYLHALPEHVCARRQGKNREIPRKNSMXLIKNSTKNRANWKVGKITSTIFGKDGVTRGYKIRTGKGYVIERPLQLVCDLEISGACDNDDPVNDALDSRDANESLPSQTVGRTRRNERKAKTAAINRLVGVIANEDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU88</accession>
    <name>A0A6P8IU88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adenosine receptor A3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570821.1">
        <property type="nucleotide sequence ID" value="XM_031714961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IU88"/>
    <dbReference type="FunCoup" id="A0A6P8IU88">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="GeneID" id="116305124"/>
    <dbReference type="KEGG" id="aten:116305124"/>
    <dbReference type="InParanoid" id="A0A6P8IU88"/>
    <dbReference type="OrthoDB" id="5949920at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570821.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37050" checksum="D8974EDEEEB92433" modified="2020-12-02" version="1">MVADEVFSCGHFTKWILLTKELYVSNYVLVATLVLLSVPSAVLNALVFIVIWQNPSLQTPSNIFLTNLAISDLAVAAVASPLMVTWKLLEIGDTTSNSTCKVAYVGGLITSAFGSFSFFTVTAATVDRHLALRLHLSYTSVVTTRKVVITCGVLLVSSLVLSSLTLIGVTEFTIGVLSSSFVCVFIMNYCYYKIYSVFRHHHTQIQSYQLGASHPESSIPNLRRFRKTVINLLYVLGLYLFLYLPFICAALTREILGDTMFTLSFMNISIAIAFLNSFVNPLVYCWRIKEFRVGIKAILPLRDVFLRMRQCCRVEKKEKIAGLNITGKSFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVF5</accession>
    <name>A0A6P8IVF5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116305231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570952.1">
        <property type="nucleotide sequence ID" value="XM_031715092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVF5"/>
    <dbReference type="FunCoup" id="A0A6P8IVF5">
        <property type="interactions" value="1357"/>
    </dbReference>
    <dbReference type="GeneID" id="116305231"/>
    <dbReference type="KEGG" id="aten:116305231"/>
    <dbReference type="InParanoid" id="A0A6P8IVF5"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031570952.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38305" checksum="42BFDD6A9B3364FA" modified="2020-12-02" version="1">MVVSRLEPTLTNKVINHSINSKKNKHEEKEHEENIEEKENGKNGKHWIRRFGCEFCLPEDHNIDEYKVFYIGQQSLNLTNLMMSYNKCQFYSYDPVMDTARQENINVNKALMKRYYMIQKAKDAQVVGIVVGTLGVADYLEIIERLKKVLSIAGKKYYTFVMGKLNVPKMANFMEIDIFVLVACPENTLIDSQEFFKPIVTPYEMEIACLRTQQWTGDYVTDFRQLLPGASYSVDLNDKDNIVDEDDCPDMSLISGQMRPNYKANAESSQSSDTSVVERNQNTTISTQRHTSGAEFLASRSWKGLEQNLGETPVRQAKEGRIGIASKYTHETDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWA9</accession>
    <name>A0A6P8IWA9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116305570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031571369.1">
        <property type="nucleotide sequence ID" value="XM_031715509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWA9"/>
    <dbReference type="FunCoup" id="A0A6P8IWA9">
        <property type="interactions" value="2016"/>
    </dbReference>
    <dbReference type="GeneID" id="116305570"/>
    <dbReference type="KEGG" id="aten:116305570"/>
    <dbReference type="InParanoid" id="A0A6P8IWA9"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000092">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="391"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031571369.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="85547" checksum="A1C34DEEC3C0B116" modified="2020-12-02" version="1">MPNSVEGLRFGDFSVDDWEKILKDVSQSDSARPPVEFLFDYVCSEDDQVADDDKDLNVSREAHNKSVPTGPDDSGVEIGLESEQEGVPAKHHVPVVFVPNKNVVDEVKTLEEAGVELSFCGRSVIEDIEPTNNGSTYLQDAENFPPLGSLQTQDVERSRKRRRKRKQHQRSGDVPCSSSEDSDRDKSPASIVERVSRVRSGSGNEKGSGTTENKGENQGVSENAAKKAETGQENKKSCKEGHDASSTDSKSTTETVLSIGDSSSSPPQSDVDFHTNKLPQNISDTTTTTANNNTTETSSIPNEATNKPSNAAPVSLWADLFRKPSSKQPASKVETNNVVSTQKEAIKDNNVKKVESVPIVIDIAEDKRAIRIAETLKKLSLDYTHKPLFLRGLINKANWCYINATLQALLTCPPFFNLLRQLEPLKDKESTSTPILDSMVKFSHEFNILPKQAANQGKNGKVEFRTGSSFEPNYVYKMLSTIQSSLSAKGRQEDAEEFLSCVLNGIHEEMLQLMKLLEPTTKAEPADSEQTVTDDPSVVAVNGQDIDKNDDDDDGDWEQVGPRNKSSITRMAIFPQSLVSDIFGGYLRSSLHQAGAKESANVEPFFDLQLDIQNVSCIEDALNHLAVKEELQGYTCSKTNAQIDISKRVTFESLPKILILHLKRFIYSKSGSQKLLKHVDYPLDLPIGKELLSPNVKNKYSIAQKSYKLIAVVYHHGKTACGGHYTTDMCHPIHGWVRADDTKLKSVPVNHVLKPIQGKDPYLLYYCRTDQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWI3</accession>
    <name>A0A6P8IWI3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Leucine-rich repeats and immunoglobulin-like domains protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031571746.1">
        <property type="nucleotide sequence ID" value="XM_031715886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWI3"/>
    <dbReference type="FunCoup" id="A0A6P8IWI3">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="GeneID" id="116305889"/>
    <dbReference type="KEGG" id="aten:116305889"/>
    <dbReference type="InParanoid" id="A0A6P8IWI3"/>
    <dbReference type="OrthoDB" id="5982776at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000023">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028220739" evidence="9">
        <location>
            <begin position="24"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="465"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="569"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="664"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="823"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="915"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="829"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571746.1"/>
        </source>
    </evidence>
    <sequence length="986" mass="109602" checksum="52F79B06D6415200" modified="2020-12-02" version="1">MASSPSNAQLVLCWVILCGVCWGQTPGTTSCERIKPCTCTGKRVVCQDQSLTRIPLGIPSDITSLDLSNNNIEHIDTQRLSKFKSLKELILHHNKIKKLPPWDSFPTTLTVLSLHHNKITTVPSFNTTKQHSLRKLYLNSNKIKTVGINAFTNLTRLKFLKLNRNKFTAIPLALSQLNSLANLDLSRNSIKFVSKSLQGLVLLRTLKLSKNRISGIQSSVFWGLDKLEQIYFDGNNFSSLQTVWFFGLRSLQELFFQNNRISQIQTNLADWRSFPVLRKLNLEGNKLSHITDQTFKHLLALKYLNVASNRIYHTTRGAFSDLNLLESLDLSKNDISWTVDEMNGLFSSLRNLVFLRLDGNRITAISENAFVGLENLKFLNLTGNAITSVQENAFRVLTSLGILWLNTTHLMCDCKVKWLPEWFKSQKMSLTTVQARCLHPQHLHMKSVFNITPSAFICDTSNPVPQISRHPSSQQVLKGKNVTLRCQVQVLQKNNSGVQLSWRHDRDVMKTGSITNYAKISDANMVIYTSDLKLTRIDFNDAGFYQCLAHSKFGYASSMRAKLDVFELPSFTSKPKDVTVQAGDTIRLPCGATGQPKPTISWRKDEGNTKFAAAEERRIIHHESKDLFLITGSKSKDTGYYTCSATNDAGSINVTAHVTVLEVPRFMQAMSSKTVKEDESVVLECIASGSPKPRFAWYKDDRELSLNARVLTHLNGQLLVIVKVELDDEGTYMCEVSNALGTARQSAQLTVLTGTSVKVDQKEDKESSDKKTFLGIIVVVVVSCVVGTSLVWLLVIYCARRGSNRRRKHEELHTTAAPREDVSYIPLKSYSSGSTQTSRDSPRSTATFTTSTGSQGSAFPPSTSSSETNSGSEKALTADNISSETSVKGSHSSLASSCPSDASEPLRQVIHVQIHSSDSDTEKCKSVSPARRKGASSTKDKNRTINCRCGHPCGMNVKCACGISNEISEETEHDGLLTEEYNTSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWS3</accession>
    <name>A0A6P8IWS3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116305700</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571527.1">
        <property type="nucleotide sequence ID" value="XM_031715667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWS3"/>
    <dbReference type="GeneID" id="116305700"/>
    <dbReference type="KEGG" id="aten:116305700"/>
    <dbReference type="InParanoid" id="A0A6P8IWS3"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571527.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30168" checksum="3D87011E065F34C3" modified="2020-12-02" version="1">MDSHYIAISNKYDYLYEPLHHARAPLIINNLKLKPDDLMLDIGAATGQQAHLIWKQAGLKNPVTCVEPCEALFEHARKLDGTVPVMQTAEQFCDHLVQVGSQRQFNKVLLCGVVHHIDDIVKCLGQILDYLPKNGVCFISNQSFTEKSLSSLPLTAFQLRYFKETSNPFDIILPYVKSRDDVITEVTNDEPSFRIPKSRWYYMIRNYFWSHFHQYTDKEIEESIKELDNGRFKQVKDDELITVVYKVTGVKITKKEILKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0D2</accession>
    <name>A0A6P8J0D2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Keratin-associated protein 9-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573286.1">
        <property type="nucleotide sequence ID" value="XM_031717426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0D2"/>
    <dbReference type="GeneID" id="116307261"/>
    <dbReference type="KEGG" id="aten:116307261"/>
    <dbReference type="InParanoid" id="A0A6P8J0D2"/>
    <dbReference type="OrthoDB" id="6365775at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573286.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="17425" checksum="FDF96E1AAB127193" modified="2020-12-02" version="1">MAPTLPPTQTVPVEESTLTTGEIVIIAVGAYVAVMIIALLIRQCLKAQGISLCPAWVTEQCCGSCCSAEGEPSCCAACLVSFAEMCDCSTPTKKSCMDSFCPSKQWCDETFCCCMNAQPGGEMCQDCQGPECNCGGCNCACACDIPDCSSINCLCFKLDLSGGGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1F4</accession>
    <name>A0A6P8J1F4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SCO-spondin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571625.1">
        <property type="nucleotide sequence ID" value="XM_031715765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1F4"/>
    <dbReference type="GeneID" id="116305793"/>
    <dbReference type="KEGG" id="aten:116305793"/>
    <dbReference type="InParanoid" id="A0A6P8J1F4"/>
    <dbReference type="OrthoDB" id="5966059at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571625.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33279" checksum="97AF64E79A876CFA" modified="2020-12-02" version="1">MLDGLRLTFICIILEIILIILGMAKTEFIHLGCFEDSMGQRGLPIFLGYVASIQECADKVAKENFVVFGLQLRTECWSGPNGKETYDRNGPSDRCINGTGNDLAFNAYKHLPVNGSWSIWTPWEACSVTCGGGSQSRNRTCSNPPPSFGGLDCTGVNKETRKCGTKYCPACRSIIYEPIADPNKILTNHGIEVHMTESDQMCRIKCYLNYDCVSYNLGPSPTPGMMVCQLNDADRYQHPQDYQERPGYSYRGIEVSISTFYLGLFNLACTVRYCNPSRSIVNLGESQRLKWNLEVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J255</accession>
    <name>A0A6P8J255_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116307523 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573657.1">
        <property type="nucleotide sequence ID" value="XM_031717797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J255"/>
    <dbReference type="GeneID" id="116307523"/>
    <dbReference type="KEGG" id="aten:116307523"/>
    <dbReference type="InParanoid" id="A0A6P8J255"/>
    <dbReference type="OrthoDB" id="10288136at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573657.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20326" checksum="04F1D838FECBFE7F" modified="2020-12-02" version="1">MENQICEEMGNIFGAKRVWCRLIYSRKENKIDPTSQGFNENGNQQDEPLDNFYIESYDTPCNDHLCKNYERCTYKGMGYKCKCTLFKYGKPCISTKVCDKDSCKYNQTCPALEDCYKCDCNLFKLEQVCEYAGFYLLFSGLITFCTIAIFLFIFVGRRRVRRIYTFGPFQSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J288</accession>
    <name>A0A6P8J288_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116305938 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571800.1">
        <property type="nucleotide sequence ID" value="XM_031715940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J288"/>
    <dbReference type="GeneID" id="116305938"/>
    <dbReference type="KEGG" id="aten:116305938"/>
    <dbReference type="InParanoid" id="A0A6P8J288"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038801">
        <property type="entry name" value="TAF1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049087">
        <property type="entry name" value="TAF1C_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049090">
        <property type="entry name" value="TAF1C_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319:SF1">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20641">
        <property type="entry name" value="TAF1C_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20642">
        <property type="entry name" value="TAF1C_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TAF1C beta-propeller" evidence="2">
        <location>
            <begin position="309"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="TAF1C helical bundle" evidence="3">
        <location>
            <begin position="569"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031571800.1"/>
        </source>
    </evidence>
    <sequence length="896" mass="102271" checksum="E16850DF7EA73723" modified="2020-12-02" version="1">MEMEGDPFPSFNHPFYPDGGHQQTFIDYGSVSTLNIDIDNDGRVVTTSKHRHYDKESDGTRLVEAHLTLPLFAPCKNVFTDKVFPEQRCRIHNSNFKQSLLEQTSDFYKNHPDIAFQSSVEFVGEELHCKPWDPKCFYYSKTIQMVHMTKRQHLNPNNFLDRFCDLFVTFPLSKDLGLMLDKRYALPRGLCEAFHDIPPQLLFDLLNESVEQRKNEKLYFDILQGNTLAYCNMPDSESGQDIVLFYPSGPCLEVLNSSIVRLKDTGTLSDKSRKLYRKPALLTCSKNEDGKGTIRQISAVSYEHGNTFVATRSQYGCTFFSATISTTKDSPEITLKAIDNLVKEDQAMSLALSPYIPGEGVVAMETGQVYIWHLGKQVETRDVPMVAPKENWPWYQCVYASHPRCILIANSVEADIMDLRASGSFSRNLFSVTSKQVSTLERISAIQRNPENTHHYVIATDQSLLIMDDRFIQHPVLKWRHHLQDPVQYIEVINSAVPRDTVITVSGSQHHETHCFQYNWGECDVRYTFPYGGENLVNPPVSTVLPWKVSSYDEWPSHVPTSILPISSLLDDRLSQPLIGVCCIPLSSKEDRKGFTAFQMSSAGDLFYQPFIQNDKGKGRIYRYDPSTSKDSKNVRFSDADITFLKSWIDELVAMANENDEYNEWPLRSNMLETDCEDLFRKMMYLELPHQSCFLCNPSTANSYATVQEEQDNDEECVCPRCEIDVKNGRQVKKCQTLNIQCREKIKSEVQCVDLNFVNNADSYKDPLSQNLFQNWFSDTHVPLNLGSTDKIDKEKEVPTIASNVNVKNENKNEKQATKETSTGESSQLNNEVLAQKIFESVEEQSFDLPMKELSEPSTVTPLKCSEPIQSPLKVGNVSPRKQVKRIKRLNQSMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6B4</accession>
    <name>A0A6P8J6B4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hematopoietic prostaglandin D synthase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572865.1">
        <property type="nucleotide sequence ID" value="XM_031717005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6B4"/>
    <dbReference type="FunCoup" id="A0A6P8J6B4">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="GeneID" id="116306876"/>
    <dbReference type="KEGG" id="aten:116306876"/>
    <dbReference type="InParanoid" id="A0A6P8J6B4"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572865.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23721" checksum="7DC3E3ADB2D01A17" modified="2020-12-02" version="1">MPVYKLHYFNVRGRAELSRLCFAAAGVDYEDLRHTPEEWQQMKKDNVTPLGQLPMMEVDDEKFSQSMTIFRYVARQTGLCPTDSLQIAKCDMIVDTENDLAAKRIKYYYEKDEKLKEIYKGEYFQTYLPEFVSKITGLLKKNNDGKGFFIGDKMTYADIAVFNVCDTYYSYITDYPELKAHHERVGKVPGIKAWLEKRPKTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6M6</accession>
    <name>A0A6P8J6M6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116291238</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116309033</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116309033</name>
        <name evidence="2" type="synonym">LOC116291238</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554243.1">
        <property type="nucleotide sequence ID" value="XM_031698383.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575424.1">
        <property type="nucleotide sequence ID" value="XM_031719564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6M6"/>
    <dbReference type="GeneID" id="116309033"/>
    <dbReference type="KEGG" id="aten:116291238"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027965">
        <property type="entry name" value="SPMIP10"/>
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        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35247:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14983">
        <property type="entry name" value="SPMIP10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575424.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12503" checksum="A734AF8685988642" modified="2020-12-02" version="1">MEKENMQSIPVWSRYHPVIPQRYVPAWTQDMENRTLILENTNATKYPCGPHDTSIYLCRRERLNNVEPSAMVNSKSIKVPRERLLRPWFHSPLSRFQSSLMFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J883</accession>
    <name>A0A6P8J883_ACTTE</name>
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        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574008.1">
        <property type="nucleotide sequence ID" value="XM_031718148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J883"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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        <property type="entry name" value="ECM_Assembly_Org"/>
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        <property type="entry name" value="VWF_A"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
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        <property type="entry name" value="COLLAGEN ALPHA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027684915" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031574008.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="53216" checksum="A4E5505BF0C6077C" modified="2020-12-02" version="1">MIVNEIIYFFASRQAMIFILLLSSCLCVTAENGYGYEVEVQPLNEAPDTAQPFKGVPTGRYTFLDAIKTPQNPGNQPALDKGRTPEMRLGLNTVHSQNPDNQYVMDLVLVLDSSYSITLFGWMKIKNAAKKLIDSLNISPQGTHVAIMKYSTDVETYYMFDPKASKDKLKQLLDNLQFDGEWSRLDIAMQSVDRHVFVPIGGARLGKVPKAVVIFSDGKSDGPTAPEEEIDWQQRLVEPLNSLRNKNVDIFSVAAGVPDKDALEAITGSSARVFDIDSVDNLVAAIKAESLQITPPLPPLPPAAAAAPTTSATTPPTPTTTPLPTPSPQAAETTILSNIITLTTQETCTAIETLTLTTLVASTPVTTVITTETQTTLLTATETASTVVETATQTDTVTETVTATTTEPLTSTAKITATSTVAATATATKMVTLTTMVEVTSTTYAKAVATPIPITLVGSVERKKKKKIPRAKRWYEDYLPKFVHRWMAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J8X6</accession>
    <name>A0A6P8J8X6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphatidylinositol 3-kinase regulatory subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116307342</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573390.1">
        <property type="nucleotide sequence ID" value="XM_031717530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J8X6"/>
    <dbReference type="FunCoup" id="A0A6P8J8X6">
        <property type="interactions" value="2647"/>
    </dbReference>
    <dbReference type="GeneID" id="116307342"/>
    <dbReference type="KEGG" id="aten:116307342"/>
    <dbReference type="InParanoid" id="A0A6P8J8X6"/>
    <dbReference type="OrthoDB" id="3175255at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20830">
        <property type="entry name" value="C1_PIK3R-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pi3K21B, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
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        <property type="entry name" value="RhoGAP_dom"/>
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        <property type="entry name" value="SAM"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
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        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00678">
        <property type="entry name" value="PI3KINASEP85"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
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        <property type="entry name" value="C1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
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    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_DOMAIN"/>
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        <property type="entry name" value="ZF_DAG_PE_1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="169"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="13">
        <location>
            <begin position="325"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="9">
        <location>
            <begin position="552"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="9">
        <location>
            <begin position="826"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031573390.1"/>
        </source>
    </evidence>
    <sequence length="932" mass="107872" checksum="96076F53681B76B0" modified="2020-12-02" version="1">MDTGWAQFRTLYDFIPRNDREIALLEGDVLIVAKPYEDSKDWLVGQNQRTGQHGDFPGNYVEHIGDIDTIEEDKIEPEPEKPPPVPPRLPRQPTQDGHKLLKMYSAVPVFCYRCEDFIWGRVKEYYKCQDCNLTCHLGCAIDLKNFQCIKTDAEDESGYERLVSSIDQWGTEDVMTWLATTNYYTYAEAFRDFGVDGCTLPQLNEESLVKIGVTDQAHQQSLLYIIKELFSSDSPERQSNIFCGVQKAPKGSDGGHTFKAQNFYSLQWCDNCEKCLWGLHDQGLQCTVCGLCCHRKCKIDGIPVCPMRRVKGARDSDIEDPVFGQELSSCFQSSSRPAPIVIMKCVQAIEARGLKVEGIYSWTPEGSEKYNLRSALNQNPESVNMKDEEWNNPHCIASALKMYLQELPTCLFTEEKYHDLIEICQSNPNCIDNLLREIDTLPHPNKSVINYLMKHFHMVCKHQQHNKMSSMDLSRIFAHILLKPPKRDLKKMATNHEIQIQILDTLINQGPWSVEEIAEEAPPVPPRPHKPQSQSGSVSRPDPLPDLKEQVWYWGEASKEQVQERMKDTEDGSFIVRDSKRFQGEYTLTLMKGGVTKLIRIMYKNNKYGFSEPLTFHSVVELVNYYKGRSLAQYNPKLDVRLTHPISKYEQEDEVAQNSENITILEDLEKINAELDSETKNFEGLRKEYDESIQNIADLQLVLDAHKSVVLMIEEQIRIHESFQREAPPQARVMLRTNFELLKHRLNEAQCELLESERENSNITEDSRQKDQQMNILRSKIIELQKNRQRYMDILKEKGYSHDEIKDIVNEGIYQIPDIDMSEKNWRFGKITREESENLLKDCPDGTFMIRESINRKDEFSVSLSFDFKVRHIAIYNDSRGHFGFAANFMLYESLADLVNHYHRNSLQKHNPHLATKLAFPVKLVLEQRKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9I3</accession>
    <name>A0A6P8J9I3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574428.1">
        <property type="nucleotide sequence ID" value="XM_031718568.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308184"/>
    <dbReference type="KEGG" id="aten:116308184"/>
    <dbReference type="InParanoid" id="A0A6P8J9I3"/>
    <dbReference type="OrthoDB" id="5985555at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="684"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="809"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="851"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031574428.1"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118290" checksum="BBC4D4D04549B87B" modified="2020-12-02" version="1">MHPPLIRFCSRMWNLQIELNAIKISLRKLRHLKVVRQKKNLVTSNVASCQNYESIHPGLLFDDAVKALSDISGISCHNDIPLQIAKALDFQPLALACAAVYMKHIKSTDWTKYLQKLEDGKREATEKEYQKRSLTYPQTMTAAVRMAVDKEVSEDKVMRHAFEFLSVIAPEPIPLQYVVQYVMNCLSDEDEDLVASTIRSSSLVLSSKDDLEEVRVHQVVHHSLQVVMLNKDKKLNVDIIWNVILAFSWINELDLDYIPDVVSTRRLVEHLTALSLVIQSNMEFLRNDVLNYSNQKHVDESYCLRNIRMICNIHGRYEAAGICFRISLIIVEHFCDEKDPRLTILLNDIGDNLFYLGNYKEAEKYLRKALYKEENSSGDCHFTIIATLNNIGKTLLELRRQDEAMKYVERALSIQKRMYGEEHPLWARTLSIQGSIFYRMGNLEQAKLCYEKALAIEESQHARERHXELNXTQGNMGRLLRELGQLEESRRYLERAIXSTEGIYDXKHPALAFLLRNLGDTYSAQGEFKAALSCFERVLDIEKKKYGEDKRPGQATTLNRIGKCLHTFGKYEESKFYFERALAISQNVHSDDVSHPSLVETMNNLAYSLIALKQYKEANILLEGVLERQECSFEERDPNDAVXLYXXLSTXLYQMQQHQESKKYLDKALAXQERCNNLPPETLAITFNNLGXQECKFGRYAKADEYYQRAVXIKEKICPSHXELGTMLSNRGEALSLLGKYEEANACLKRALSIIESVXDKQHPEQXDTLLTLGNNSIRMQNYEEAEAYFKKAVSXNESYYGKQHXEVADSLCEVGETVLNLKQYEECRTYFERALTIYESYYGKQHPKVANTLLKLGKTLFHLKQYEKGATHYERALSIKDSDNAKEQTKNATILHSLGDSHVERKQYEQAVVFLEKSYAIASSFPEGEYPLLANTVYCLGISNLELKRYKEAKIYLEKTLVMIKNGLGGETSRLVADIQDKLAIVTFRKEKKKEQKQKREQRQQEKEQRRDQHKKKYVNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9R7</accession>
    <name>A0A6P8J9R7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573580.1">
        <property type="nucleotide sequence ID" value="XM_031717720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J9R7"/>
    <dbReference type="GeneID" id="116307459"/>
    <dbReference type="KEGG" id="aten:116307459"/>
    <dbReference type="InParanoid" id="A0A6P8J9R7"/>
    <dbReference type="OrthoDB" id="10282184at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573580.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39126" checksum="3905696DDA0049FD" modified="2020-12-02" version="1">MENQDSTKCFLYDILRVETIRELEAYIKDGKCTLAELKDCFGTFLSKLPEKELEEIDNVKKFVEALDKQGVIGANDVKLLKVLTKKIGLDKLKEKVEEYEADCSDDVTRSLATMENQDSTKCFLYDNLRVETIRQLDAYIADGEGTLAQLKDRFGTFLSKLPEKELEEIDNVKKFVEALDKQGVIGANDVKLLKVLTKKIGLDKLKEKVEEYEADCSDDVTRSLATMENQDSTKCFLYDNLRVETIRQLDAYIADGEGTLAQLKDRFGTFLSKLPEKELEEIDNVKKFVEALEEQDVIRANDVKFLKALAKNIELDKLKEKVKEYEADCAGNVRRSSVKNHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCJ4</accession>
    <name>A0A6P8JCJ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine beta-lactamase-like protein LACTB, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574305.1">
        <property type="nucleotide sequence ID" value="XM_031718445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCJ4"/>
    <dbReference type="FunCoup" id="A0A6P8JCJ4">
        <property type="interactions" value="992"/>
    </dbReference>
    <dbReference type="GeneID" id="116308084"/>
    <dbReference type="KEGG" id="aten:116308084"/>
    <dbReference type="InParanoid" id="A0A6P8JCJ4"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052794">
        <property type="entry name" value="Mito_Ser_Protease_LACTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520:SF1">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="131"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574305.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61448" checksum="9C9BC338C52947AC" modified="2020-12-02" version="1">MAAATTTFASKSKSFVNQSFFLPTRLLAFRNTNLTCLAIKRQITGLSSGKEVLFKSQRSFRSVFLAFGTAVSLACVLVLRERNRKVRCEEQALEDVKSDDSKPTSSDLCPRTRLLDPVSLKVAIEESRVFLQQVSEETGAPGLVVAVSIDGKLVWSEGLGYADLENNVKCTPKTVMRIASISKPLTAAAAAKLYEQDKLDIDAPIQKYVPTFPQKFYKGKQVTITTRQLLSHLGGIRHYNKNTLPKEDCETKKEDNAATSNQDQEKDNTEKLSKSERKSRKENKKEFDNEEYYIKDPKTIIESLALFQDDPLVGEPGEKFLYTSHGYTMVSAVIESAAQEDFLSYMKKLFRELGMNNTGPEFNHQIIYNRARFYQRDKKNGLVNAPYVDNSYKWAGGGFISTAEDLVKFGNAMLYSSQVGHDDKLLPGILKPETIKEMWKEVDRNKGTAHKDGWYGWGWYVLSDKQTHGACRHVKQTIFHTGGAVGAVSVLLIRPHYHTQPSVTSPPTPPGGIVVSIIMNLQETSRSIQATGKQVADIFEEKLEEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCN5</accession>
    <name>A0A6P8JCN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaredoxin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575363.1">
        <property type="nucleotide sequence ID" value="XM_031719503.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A6P8JCN5"/>
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        <property type="interactions" value="3255"/>
    </dbReference>
    <dbReference type="GeneID" id="116308978"/>
    <dbReference type="KEGG" id="aten:116308978"/>
    <dbReference type="InParanoid" id="A0A6P8JCN5"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575363.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39348" checksum="F018602F529FC9D9" modified="2020-12-02" version="1">MRVRRCLQTKCQVSQAHSITSNMAVNEVSSSAQFDKILSESSRALTVVYFFAPWSPQYGQMSDVVQVLSKDNPHVTFVKLEAEKIPEVSYKYEISAVPTFLLFKNQKVVDRINGANAPELTKKVEHHSSIITPPQVIDEPPKEDINTRLKNIINSSPCMLFMKGTPEEPRCGFSRQVVEVLKNVGADYGSFDILKDDEVRQGLKNYSNWPTYPQFYVNGELIGGLDIIKEMAESGDLQSMIPKKQDLKSRLESLINSSPVMLFMKGNQDAPKCGFSRQMVGILAKYNPRIPLKTFDILQDNEVREGLKKHSNWPTYPQLYANGELIGGLDIVRELDENGELEEALGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JDQ1</accession>
    <name>A0A6P8JDQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116308339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574595.1">
        <property type="nucleotide sequence ID" value="XM_031718735.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574596.1">
        <property type="nucleotide sequence ID" value="XM_031718736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JDQ1"/>
    <dbReference type="GeneID" id="116308339"/>
    <dbReference type="KEGG" id="aten:116308339"/>
    <dbReference type="OrthoDB" id="5954629at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574596.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40661" checksum="358855FD69F8F336" modified="2020-12-02" version="1">MVNSTNNSTTNSDVVKEGGPTMRALFGVVAGLSLVGNLLLCIVILRRRTMLTKTYNILIFNLAIADMLTGVFLFMTPGYVIAQESFPLLHGNSGDIFCRIVFSTYFLFCFGKASNATVMCLAIDRWYSVIKPIRYKIAFGKRRLLGYIALIWISSAFTEAIGLSITKLENGRCKWVDPPYDYNAERVFLLVHVMVTFYIPSIVTWVSFAQIWYNLSHTTINNQNHDIRAKKLLVRMCALAAFFLTLCWFPTETFFVLKKFNVLILPDIWYWVFNLLGMFNSCINPWVYCLSNKQYRREFQRIVPIVLSWNEQRGSWRPTHPTNFRQKVGAWDSTMGVQNMGIEANDSSKNAASVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2K9UYP1</accession>
    <name>A0A2K9UYP1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Globin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Neuroglobin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290354</name>
        <name evidence="8" type="ORF">A.tenebrosa_tadh6000210</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Evidence for a large expansion and #subfunctionalisation of globin genes in sea anemones.</title>
            <authorList>
                <person name="Smith H.L."/>
                <person name="Pavasovic A."/>
                <person name="Surm J.M."/>
                <person name="Phillips M.J."/>
                <person name="Prentis P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KY810199">
        <property type="protein sequence ID" value="AUV50078.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031553221.1">
        <property type="nucleotide sequence ID" value="XM_031697361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2K9UYP1"/>
    <dbReference type="GeneID" id="116290354"/>
    <dbReference type="KEGG" id="aten:116290354"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01907">
        <property type="entry name" value="WORMGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AUV50078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553221.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21298" checksum="B738E6AFDA411595" modified="2018-04-25" version="1">MSEHPSVVSQWNLTTHINLLLFGEYLKDLTMSILRMFSFGSISEPETKLDPASIKLIRESWSEVEKGDLQETGLVVFRRLFEIAPYLRDLFPFGYNPDGKDLKAHALGVMSTVGVAVRGLDDLESLKPKLVELGALHKGFEITDKEFKHVGEAIIWTLDKGLGDQFTPEVKAAWVEAYGLITTTMKEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0K4</accession>
    <name>A0A6P8H0K4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor A domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549213.1">
        <property type="nucleotide sequence ID" value="XM_031693353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0K4"/>
    <dbReference type="GeneID" id="116286779"/>
    <dbReference type="KEGG" id="aten:116286779"/>
    <dbReference type="InParanoid" id="A0A6P8H0K4"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028388857" evidence="1">
        <location>
            <begin position="31"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="87"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549213.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30867" checksum="5E74BB9608F59980" modified="2020-12-02" version="1">MPHRSVMGPLRVLYISIVIFHVALTKQANSEQDQSQTMPAAIDLLFQNSNSPHKGGTPVTGQSGFRKCPPCPYRKGPKAPVCKATVDLGFVLESSSNIDRVEPGSFRRLIQFVGLIARKFFISEDKARFGVVTYSSRPKLLFGMTGNISTIARGLRNAKVHREPIAKTGIALKFAYRQLLSTSSRFNKVLVVITDGSSSDSVSNIAKAIKGRGIQILSVGVGRYFDIHQLNAMASRPVLYHVFTGQFSKIIHTRNELVKKICLGVGGSYISPSKRPCLCKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H139</accession>
    <name>A0A6P8H139_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell death regulator Aven-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550119.1">
        <property type="nucleotide sequence ID" value="XM_031694259.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H139">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116287574"/>
    <dbReference type="InParanoid" id="A0A6P8H139"/>
    <dbReference type="OrthoDB" id="5978465at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026187">
        <property type="entry name" value="Aven"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524:SF2">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="3">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550119.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41756" checksum="6F5611C03331AE21" modified="2020-12-02" version="1">MRPDEHKKKKNAEYKKKHGIQAKKESKKEEIKKDKSEKPQXSEEKQENTSKNAVCETRRFSRRKVTSNWDRYEDSEVGGSDDAYQTIGRRGADFTTLIERAGDSHSQFRFQAEKEWEEESIGIGVQESQDVLKINFEDLSQSLNSLPLYKKLNIEENVIYSEHQEVDYDQRATTIKGMLKGIDIHDALENIAEVNQKRSSNLSLNQQPKPQLNFNFLPSRADSPTTQNKKDTTNLSQSMKDPSSETSYGLNASAXTGTLHSMGVIKKTRQQDDDELDCLLSLENGQHQENSIEEPLDAKKVPNNIPLQIDFKMPDTQATEIDATKTSLPLDKNTTSQDHSPSGKKSETPSDTQKPKEDLEDWLDSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H375</accession>
    <name>A0A6P8H375_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550068.1">
        <property type="nucleotide sequence ID" value="XM_031694208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287526"/>
    <dbReference type="KEGG" id="aten:116287526"/>
    <dbReference type="InParanoid" id="A0A6P8H375"/>
    <dbReference type="OrthoDB" id="5954753at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="857"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550068.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119781" checksum="C0DB1CB917F99C6E" modified="2020-12-02" version="1">MIRRIKINDNRQQSGLCPGRYTGIISRVGYLTDTLIECFAQEHSVFKPYYSFSSPFITLDDNFISEFRISTQAECEDKNAYNTLEDAHLKKEEYDDAMSYSTKCLAIAQESGDKVAEMYAYMTLGNAHLKKGEYDDAISYSKKCLDIAQDSGDKVTEMHAYMTLGNAHLMKEEYDDAISYSKKCLAIAQESGHKVPEMGAYMMLRNAHLKKEEYDDAISYGKKCLTIXQESGDKVPEMGAYMMLGDAHLKKEEYDDAISYGKKCLTIAQESGDKEAEINAYMTLGNAHLKKGEYDDAISYSKKCLDIAQDSGDKVTEMHSYMTLGNAHLMKEEYDDAISYSKKCLAIAQDSGDKVTEMHAYKILGNAHLMKEEYDDAISYSKKCLAIAQDSGDKVHEMNAYMMLGNAHLLKEECDAAILYSRKCLTIALASGDKVAEMKAFILLGDAHLEKEEYDDAYSFFTQGRTIAKELGDNYNDIFFGTRINGIYEIVGVSEGYSELFSELEFPEGFLDGIQITDRFLHSLLGYVRNKASSQYKEAISCLETCMALGKNSINKDEYRRQLWTCMHEIAEMHVLLGDYEKGIQYQQEALDVARKQGSKSKQAKSHFSLGKVFYKLKQFENAEQSFKESLMCYELIFIGLKQNDLFKIAFVDQYKETYKLLLKVLIERNKKEEALVLSDHYRAKALKDLLVSSYGMKKEQTADEGLQYADVQSLVSSSNYTLLFYSTCFEDLYTFVVEAGNELGFSDQHFEYCDICLDKLVDETYDDMKVRQVIHCEDRSLDNMHYFEENKNPKEDELTQLLIQHREKRLSDQCRSISECRGNPTENCAESSLTSGLEKSYNKLITNIKCLIKQDEMVIIPEGALCRLPFAALRDPDTGQYLSETKRIRMAPSMASLKLLQEYPVEHHSRKEALIIGAAVVGPVMLDGVETKIPFLDGIIQEADEIAIMLGVRALLSAYATKPVVIKRLQEGASVVHIAAHGSLEKATIVLAPSPEIRASKIPDEEDYMLTMADVQQTQVRAQLVVLSCCHSGRAGDNSRKPGFNETPSIMASGLTLGDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5T6</accession>
    <name>A0A6P8H5T6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Centrosomal protein of 290 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116289006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551739.1">
        <property type="nucleotide sequence ID" value="XM_031695879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5T6"/>
    <dbReference type="GeneID" id="116289006"/>
    <dbReference type="KEGG" id="aten:116289006"/>
    <dbReference type="InParanoid" id="A0A6P8H5T6"/>
    <dbReference type="OrthoDB" id="6351660at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097711">
        <property type="term" value="P:ciliary basal body-plasma membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905349">
        <property type="term" value="P:ciliary transition zone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026201">
        <property type="entry name" value="Cep290"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879:SF20">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="16"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="646"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551739.1"/>
        </source>
    </evidence>
    <sequence length="886" mass="103474" checksum="50661F691A51CE92" modified="2020-12-02" version="1">MQAEIAEEEAAKVMKDQSLIDENELLKRELEQYRRHAGAGGDDFMREIQHLSNRNRILEQDIHDKDEALYEEKDKADKLSVKVGEMEKDIRNLKRELERSRMDGRDLQRQIEQQRETLAMRRGGDGDIKSTVAKKNKELSEYLDEIKLLQEENEALGEQFRNVKKELQESAAEMDKMTDEYTKLKLILQQSDLILDEMRRERDALRAQVQDLRVQVSTKTDADDQIMMAVNLKVEEWKAVLAKKEAEIEQHKGIISELRQRVTGLEMDSDRSSMAMLQQALMEKDEQIQMLRQELEKASVEMKGVTEQVEEVKAQAGKGVPSAYQQKKIAELGSTLKREQILSAQERERLTQAEEAAKRKDKQLNDLMARMMQYEKGEYGLSEAVQEIKESKAQIRIRDENIENLTNQVNKLDLYANDLEMENEELRERLGMDPRDKLDMEDIRQKKKVKAEQASAMNRVLVKEIERLEDERLRLKKQLRKQAMHRGARAVELGITAEDLADVEDEPERVVFRKRIIDDSDTEEARTRNKRLEKDIEKRDKESDKIKTEVKRIEAENKELKDENKQLEIGLREILAQLRETAEQNAATMNRDPQQQEQQQEQQQQQQQQQQQEQQQQQQQPLKIQVPALEKLMAQALDDSVSGKDLENANKQYNELTAKYRDLLQRENTLVSRSAIVETLEAEVKVLQDRETELKKDMTSLKEKNYSMEQMLNELIAKDDKSVGDSSPARKEEINRISRKLATLEMKELNERERADHSTRKYTQLKKVFDELEQRNAELEQKFGEIGKLNFEAQRIERHLREELEGAVTRNMHESVVKRLQSCEESEASLKIEVSRLKEIAEVAAHQAEAVRAHQEGQEKELMALRTQLYDVQMESDEKTIIGKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H669</accession>
    <name>A0A6P8H669_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116288256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550888.1">
        <property type="nucleotide sequence ID" value="XM_031695028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H669"/>
    <dbReference type="FunCoup" id="A0A6P8H669">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="GeneID" id="116288256"/>
    <dbReference type="KEGG" id="aten:116288256"/>
    <dbReference type="InParanoid" id="A0A6P8H669"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006008">
        <property type="entry name" value="PRK08139.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550888.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32205" checksum="076130DD8C964CF7" modified="2020-12-02" version="1">MLRYLNRLHFNQCQISTVFLSRSFSRSPVSRKEDSLTVCNQDKGIRRIILNNPKKRNALSLDMLNAIKANLLHNLDNELRVIILSANGPVFSSGHDLKELSEERSTEYHQQVFHRCTEVMTLIQDIPYPVIAQVNGLATAAGCQLVASCDIAVASEKSQFATPGVNIGLFCSTPGVALSRAVPRKVAMEMLLTGHPISSQEALIHGLLSKVVAEDSLGDEVNKIATKICETSQPVVAIGKGCFYSQVAMNRDDAYSQAGAVMVENLKLSDGKEGIKAFLEKRKPIWSHKTDCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6Q2</accession>
    <name>A0A6P8H6Q2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Snake venom 5'-nucleotidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116288506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551166.1">
        <property type="nucleotide sequence ID" value="XM_031695306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288506"/>
    <dbReference type="KEGG" id="aten:116288506"/>
    <dbReference type="InParanoid" id="A0A6P8H6Q2"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="82"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="7">
        <location>
            <begin position="358"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="709"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="738"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031551166.1"/>
        </source>
    </evidence>
    <sequence length="780" mass="86710" checksum="87CF81E38719B8DE" modified="2020-12-02" version="1">MGCSVSLEKSSVRESARLDQSCPNKTKTNVTKEEGSEKPKQNGEIGSKLPQNIEQNNESHNSVQIETGGLDSEVKIPSNCLTILHFNDVYNIEPRDKEPVGGAARFAHKLASYKHLNPFTVFSGDALNPSMMSSVTKGKHMIPVLNSFDINIAVYGNHDFDFGVDDLIEVKDKTNFPWLMSNVTDKATLGQLAEGEITRMFEWNGKKIGCIGLVEEEWLATLATIDPSEVIFQDYAELGTKLSKQLRDEGADLVIALTHMRLHNDTRMAELSSGIDLILGGHDHHYEVKDVNGVKIIKSGSDFRELSKINIIFSDDNNFDIEVEKIEITXDVPEDPELKKIVDQYMDIMKESMEETLGQTEVELDGTFASLRTKETNLGNFIVDIMHNVTKADVVLLNSGTLRSDAIHPPGTFKKKDLVAILPMPDSVVVLELTGEQLLKALENGVSQWPKHEGRFPQISGMKFAFDPELQPGSRVVKDSVIIDEEKLELKKVFCLWRHTGDSPASLLDAEKHHVKVNPKVEGRIINIRDKNAEIRETSQNQEKTEQSNELDDDDEKEVVTKVISGCIETAANDSREENDTNGNSKRDGPSIQVIAGGANNTGGETSNETNVNEENQPDMSSAYPDKENQPDLATEDDYWDLWEAVKVDDIDVVKNLHEEKHICLTRLQDNKTILHLAAERNASKVVEYLLTKGQLNPNALDEILHGVPLHGAAEYGSVDAARSLIEHEANIDQQDLVGNTALHIACTNDQMNFQHFLLERGANTTIVNSDGETPQLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAM6</accession>
    <name>A0A6P8HAM6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopantothenoylcysteine decarboxylase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">CoaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553514.1">
        <property type="nucleotide sequence ID" value="XM_031697654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAM6"/>
    <dbReference type="FunCoup" id="A0A6P8HAM6">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="GeneID" id="116290582"/>
    <dbReference type="KEGG" id="aten:116290582"/>
    <dbReference type="InParanoid" id="A0A6P8HAM6"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000004">
        <property type="entry name" value="Phosphopantothenoylcysteine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="14"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553514.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22400" checksum="A24EBA6894DC98CA" modified="2020-12-02" version="1">MADEEEVQNSQFHKNVLIGVTGSVASIKLGKLIQELLLSKIKLNVQVVATDHATHFFDVNEIPVKVYRDTDEWQSWMKMGDPVLHIELRKWADIMVIAPLDANTMAKIAGGLCDNLLTCIVRAWDMNKPLIFCPAMNTHMWSHPITATHVESLCKMGYIYVSTTEKKLACGDTGTGGMAEVSTIVDKTFKTLQEKHKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBK4</accession>
    <name>A0A6P8HBK4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Presequence translocated-associated motor subunit PAM17, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116287339</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549870.1">
        <property type="nucleotide sequence ID" value="XM_031694010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287339"/>
    <dbReference type="KEGG" id="aten:116287339"/>
    <dbReference type="InParanoid" id="A0A6P8HBK4"/>
    <dbReference type="OrthoDB" id="5980625at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031549870.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28291" checksum="85E5AB514752702E" modified="2020-12-02" version="1">MLGNVSSKMAAFGVRNVRTLRTFSFLLPKRQTFLXNHLNEEFLKGSRCXVVFSERSFSSSPSCKSQDSGDGLNSKADTLEVKKTFDLSFAEYQKLKRKIRSRQRIAGLPIAAVALVTSSAVSAYLNPNMFDAPPDQIQPIMGMDPLIFCGLCGVASAGVGYVVGSALFGSLWRLFNKDVSSKMEQREADFLKRISAKRAASFSKFEDDYYGESIKTLSDYRQWLREQEKKKKAAESFEKKSEDKQGQEQTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCJ8</accession>
    <name>A0A6P8HCJ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Hatching enzyme-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116291176</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554164.1">
        <property type="nucleotide sequence ID" value="XM_031698304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCJ8"/>
    <dbReference type="FunCoup" id="A0A6P8HCJ8">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="GeneID" id="116291176"/>
    <dbReference type="KEGG" id="aten:116291176"/>
    <dbReference type="InParanoid" id="A0A6P8HCJ8"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028230426" evidence="17">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="18">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="15">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031554164.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33058" checksum="4DB8AAAFBD85FB2F" modified="2020-12-02" version="1">MKSLILLGLLAWVAVTLAEDDDKTMAVKYLSQFHYISPSRSGNHDVKTAIRNFQRFAGLPVTGEIDEATVRQMKKPRCGDPDVDDSGSRIRRYKLGSKWGKKHLTYFVEYGRDLSSGEQDRIFARALKYWADVSGLSFSRASSASSADLKVCFGGKSHGGSSEGVCSEVFDGPGKVLAHAFFPSDGRCHFDEDETYTDGTSSGTNLLWVATHEFGHALGLHHSDVRNAVMYPYYTGYVPNFRLQQDDINGIQAHYGGPGSGGTSTGGGGSCVDTDSNCPYWTSYCTNNDWVKDNCKRTCGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCM8</accession>
    <name>A0A6P8HCM8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287876</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031550442.1">
        <property type="nucleotide sequence ID" value="XM_031694582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCM8"/>
    <dbReference type="FunCoup" id="A0A6P8HCM8">
        <property type="interactions" value="2718"/>
    </dbReference>
    <dbReference type="GeneID" id="116287876"/>
    <dbReference type="KEGG" id="aten:116287876"/>
    <dbReference type="InParanoid" id="A0A6P8HCM8"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550442.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37393" checksum="C9542A88311AC153" modified="2020-12-02" version="1">MADTEKLNVDSIIGRLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVSAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGPDIVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKKKFPYGGLNSGRPVTPPRGQQAKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCV6</accession>
    <name>A0A6P8HCV6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">G-protein coupled receptor 161-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17" type="primary">LOC116287804</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550359.1">
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="116"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="137"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="201"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="237"/>
            <end position="258"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="293"/>
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            <begin position="38"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="360"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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    <sequence length="635" mass="71923" checksum="07008F0EC1A6FEEF" modified="2020-12-02" version="1">MDGNDTSNPVDTVALYSPEISIALIVLLGLFDIISIVANGMVLMTVYCNPRLRSNTNVFITNLCLVDLIAGCLLLPLVIDSIGRHEARFGVLCELVGFIDATYSCASSLTIAVIALDRYHSIVNCLYYENIVTRRRTIIAIIWIWLQTLFIALCPLAGWGRYTFDSAQFKCSLDLPDRNGFLWFMFCTSVVIPFSVIVFCYTQIHLVARRHAKNMVAIHIQDTGKRVRAVSTRKTRLVYLVVGLYTTCWLPIYIVKLFQSIASDITIPPSVITLSTVLSLVNGSCNPFLYALITSQYRAGMNRMNRRFKRKFGRTVATPSVEQSKSSWSVSRPISNLYRYFQENDGGNMLACIGRTYSDDDDRLERPQRSQTFFNPKNTTPSPSNQRKNQPQTLQIPNKSKKCKRSVNGWVQEDKDTKSLSIPLKTIGRQEHDEDSFSDLEVSGELKSLTGTNSSERKRNTRINQRNSDNNTFRKAVSFQTGQNYLEVIGPVSIDKQSQTTRKSNSVLGTIKEVESVETKDKHQVNKLDEDEHRCDDTKWENEESTRTKTNGDENTESGMSVESDEKFNVNNDNKTRQVNVKSARKPLDDVINNVEDNCQETLKIKDQHGEDERSAVEKTCDRDCIANYTANEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDD0</accession>
    <name>A0A6P8HDD0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membralin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031697821.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="38"/>
            <end position="58"/>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_031553681.1"/>
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    </evidence>
    <sequence length="693" mass="78506" checksum="8EBC88D7C0631E6E" modified="2020-12-02" version="1">MPGEVRNPLIHARDRLFRALFFKMALMYARSFPPMVRILLEMGVLLKAIICFIILAYIHNAFSRTPINCLDNVKNTWPRDGVLRVTISRGQAVRKLSENELKHNISNINNMSLVNTSISNRSMIGNITDYEDIMVKEGDDNSTAEIYGLIPNGRQEKNQVPVRDTLVPSAFDFLGHNKEDEKKDEYSMEYSLEYGFLRLSPEARHRLNITVMVVKLNPEEEKCFGDALSRFLLDEFLGYDDVLMSSIKKLAEKEDNKGYLRNVVTGDHFRFISMWMARSSYIVALILMFIFTISISMLLRYCHHQIFIFIVNLLQMLDLNVTIAFPAAPLFTVILSLVGMEAIMSEFFNDTTTSFYIILIVWTADQYDAICCHTQQSKKFWLRFFYLYHFAFYAYHYRFNGQYSGLALVTSWLFIQHSMLFFFHHYELPAILSQAQQLNPEDDLLADPIHFLTDEAQIPIPPAEQALQNNALPDNLQQNNALPDNSQQNNALPDNLQQNNVLPENPTQNNELPENSLHNNVLPENPLQHHSLHDNLSSNIALPDNSPHNNALHALQNESLRNNMLPKGVLQNDTKDVDALQSSALPATLLQNSLVNTTSHHSESVTLSNAVENEDFDSETKLPCSSQARTLSYETTSIEPGALTHRLGNLTGPSRSTKKEDSGVPTSPGSSSEKELSAGTEAGLSLVQKQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDY7</accession>
    <name>A0A6P8HDY7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554634.1">
        <property type="nucleotide sequence ID" value="XM_031698774.1"/>
    </dbReference>
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        <property type="interactions" value="1405"/>
    </dbReference>
    <dbReference type="GeneID" id="116291596"/>
    <dbReference type="KEGG" id="aten:116291596"/>
    <dbReference type="InParanoid" id="A0A6P8HDY7"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554634.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11854" checksum="91F07CD6E607E538" modified="2020-12-02" version="1">MAPKVEMAVGLQKGHKVTKNVTKQKPSRRKGACNKRVKYVRDVXREVVGFAPYEKRCMELLRIGKDKRALKFCKKRLGTHVRGKRKREEISGVLAQMRKQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE89</accession>
    <name>A0A6P8HE89_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550967.1">
        <property type="nucleotide sequence ID" value="XM_031695107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HE89"/>
    <dbReference type="GeneID" id="116288335"/>
    <dbReference type="KEGG" id="aten:116288335"/>
    <dbReference type="InParanoid" id="A0A6P8HE89"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGAT4 conserved region" evidence="5">
        <location>
            <begin position="55"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="6">
        <location>
            <begin position="305"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550967.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50579" checksum="91D97C94EC622C1D" modified="2020-12-02" version="1">MAAVSSKYSIQEPGIDSILSSNDDLPVPPIENSEEHEKKDFDKTTSVAFTLPITTKKNAFLVIGVPTKKRLKASYLVQTLRDLIGGLDDEEKNEVIIVVLITDFSPSSVQSVQRELFSAFPKEISSGLVRVIAAPRSFYPSLDKVQPLWGDKPERIRWRSKQCLDYAYLFNYSKDLGQYYLQVEDDVSTVKGYLKEIKGFIVANQNRSWSMLEFGARGFIGMMYRASDVGRLATFVKIYYWVFPIDILFRQFNDFHLYGNPDWLKYRPPLFLHVGAFSSLDGQVRKLEDIEVSHRMYKDSSNPPAKVSTSIRDFTKNYISAVYSTNLHGMFWGKTVKEGDFILIKFHSPVRISKLIVESGGTVAPEDYFGGSRVLYSQGNDKGQCENFILWQEFGEIGQVKLQSNEDNGTLCQCLKIEITKIRKDNKGRPRWLAIREIAVWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEK2</accession>
    <name>A0A6P8HEK2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-related protein racA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551057.1">
        <property type="nucleotide sequence ID" value="XM_031695197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEK2"/>
    <dbReference type="GeneID" id="116288412"/>
    <dbReference type="KEGG" id="aten:116288412"/>
    <dbReference type="InParanoid" id="A0A6P8HEK2"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551057.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19883" checksum="72E44F7A8F509F54" modified="2020-12-02" version="1">MARCDVMAAMLGGAFMEGRNSSETEIKEASLESFLAILEYLYTDHAPIEEGDAIDIMVLADRFCLPRLVTLCELYITKKVDKMIEKKVSDGAEYVVNLLLLSQAHNAHQLSNWCLHFIATNYLIFESNPSFTLVQGTNIEYVEKHRWPPLSYLNEVQEFEKKVGHTSKKGKCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEN5</accession>
    <name>A0A6P8HEN5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9 10">U1 snRNP C</shortName>
            <shortName evidence="9 10">U1-C</shortName>
            <shortName evidence="9 10">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553468.1">
        <property type="nucleotide sequence ID" value="XM_031697608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEN5"/>
    <dbReference type="GeneID" id="116290551"/>
    <dbReference type="KEGG" id="aten:116290551"/>
    <dbReference type="InParanoid" id="A0A6P8HEN5"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553468.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16084" checksum="007CF416A0F777B9" modified="2020-12-02" version="1">MPKYYCDYCDTYLTHDSPSVRKTHNNGRKHKENVKFYYQKWMEEQAQTLIDQTTAAYQATSHKMPNMPPPGMPPPGMMPPPPGMMMPPPAGMPPPSGLPFPPPGGMPPPPGGMRPPPGVRPPMGDLRMGPPQNMNQHRPPPMSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEY1</accession>
    <name>A0A6P8HEY1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oral-facial-digital syndrome 1 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
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    <sequence length="1164" mass="134989" checksum="4B7D52520C3CF670" modified="2020-12-02" version="1">MADEELSAEDLREKLFHTFRNRGVLDSLKSQLRNRLVTELQQTAKVNLSNGKKKPPEESSLFYHAANSLVVDHLERCNFEYTLSIFLPESGTSKDKLLTVRDLLHLLKIDKDSQLYKSLECSLSSKIKSKSFLWEIMSQLLSQHGQTTQSSMAIQTEESASIRSPSIAEKLQFIDQAFSEQAEKENEAWGSQAEQKIAEFQRKYDERKKAELEAEIKQYKASALASMRLEEKERFQREIKIAKEQMEKDYSLKAEMLRLKEKELTDLQYRQQKIQEEEAYSQRQNILQEMQTAKDQENEFKMRQELHLKTIQLEEERLKNEAEKIKTREXALKDEEKRCHQKIEDEIQRYKLQHQESYQKRLHDLELREAQIKQDKESFERSKSTYMGYYDELEGKKEQLRQMQNQFEAAKYNIATLQQQKDTLLQKLDEVRDYRTVKDNEQMLRKEKDELQNRLEEQSNKDRVNEETIKELKEKLSKPSAELVSVRNELKAVKDDTKNKEKLLKDKQRKLEARLQQESQRCAEYQRLYEEHLLRQKEMEHELDDLRAALHHTQTFLRMELERKRMSEASVSDIHDLTLPSPPVEPIPAKTSIAFAPRTNQQDSETNSFMNDTANTQELIANTKDIFDKLEKKAKDFEESYRRFQSRMKNTGLDQFTSLPPVSLDRHTLQGYPNRQAEIIDPHPSLGKDTNIDKADEFVPLSWIPVTEKNAAKMPESHVTGEHLGGSLDPLHFPSSLLPSTRRGNNTDSLTRFYSLPSFGVSEVTQNSSAPRYFGLSRTDRRPPNNTVNVSDLIAKPGSPSVISAPIDHSPIDNNTTDSGKGKKAKERHADSSTDTMRRPLSSTIDRVREGTGMGSRENDFLTSASSQRNSDHNSHVPVIDGSVFYGRKSDIDKDLSEQDSHRSSDASLSGGYLSMGTLSKPSRTRDDTRKTANTVTDSAKEKENDEVDDYNAPVPTRISLDVXWGGAQVSGTVLKEKDEESSLSIHSNPSLPSIGEKVSVPLDSVWKDTEARKTREEKEREESERKERELREQEDREWQEEKRKLEEQRRQREQEAREREQRELEELQREQELRERENMDHGRGQTDANTEKEMKEMQEQKEKESSKDPEIDPVMLQYMQMIQKKKEEEDKAKAVEPSKKESREAADIGSNSSLSQGDDNLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF07</accession>
    <name>A0A6P8HF07_ACTTE</name>
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        <submittedName>
            <fullName evidence="10">Adrenocorticotropic hormone receptor-like</fullName>
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        <name evidence="10" type="primary">LOC116288548</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="RefSeq" id="XP_031551212.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35928" checksum="B21EFC400F6158B7" modified="2020-12-02" version="1">MNTSDQAAQDNNMTLDCAPLSVYFLDVPRDNHFDTFLLAMIVINAVMAVVASCSNAVVIYTISRTPSLQTPSNILILGLAISDLSVGIFSQPSFCLFRFYELRRNLDLYCSFGKMYMYITLPLAAISFLTLTAITADRFLAVHLHLRYQDIITTKRVGITLGFIWILGSLFAVYSAMFFKILAVVISSCCFFAFLLFLDVYFIFRVCLVIRRHSLQIQSQQSAQQPINMVRFRKSAMVMVFVIGAFILCYVPYVIFTIMLGVVDEPSYGLRIGFNISETLVMSNGILNPIIYCWRIEDIRTAAVLLMRKMLRQREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHA4</accession>
    <name>A0A6P8HHA4_ACTTE</name>
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        <submittedName>
            <fullName evidence="12">Galanin receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Hexacorallia</taxon>
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            <taxon>Actinia</taxon>
        </lineage>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="12">Tentacle</tissue>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
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    <dbReference type="RefSeq" id="XP_031555784.1">
        <property type="nucleotide sequence ID" value="XM_031699924.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Predicted protein"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
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        </location>
    </feature>
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            <begin position="67"/>
            <end position="334"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555784.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41101" checksum="A2DF2EA0CCDC933D" modified="2020-12-02" version="1">MTKQTKKQTYCVEAQDNTSYLIQCSYRRAMFNITAMMCSLDKSEGVSSSMIVKTVAYTTISLTALFGNTLVLVVFRRSRDIRSVVFYFIVNMAVSDLIFPVFALPRVIGEIFNGPFTWIXNGTFGSLTCKMATFLQDVSTAVSIESLVVIALERFFSVVHAERKSFLSAAKTRRNIIAITWILAILIHIPYLIVFKVETIAGRNYCMTQWGSNIKWKRIIPVIYLVSIFTVVYAIPFLVIVVLYSAIVNKLRRLKMPGRTGSQRRRRRQERNRTVTLMALLFVVVFFVCWTPFFVFAFMLCFKWHFDFPCSQVNFRFTVILVAHLNSAVNPFIYLFCSKTFRKGVRTVFPFCLGKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHE6</accession>
    <name>A0A6P8HHE6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain collagen C4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555824.1">
        <property type="nucleotide sequence ID" value="XM_031699964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHE6"/>
    <dbReference type="GeneID" id="116292616"/>
    <dbReference type="KEGG" id="aten:116292616"/>
    <dbReference type="InParanoid" id="A0A6P8HHE6"/>
    <dbReference type="OrthoDB" id="6086925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555824.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22455" checksum="39712EFD3827BCCC" modified="2020-12-02" version="1">MIPLGPPGLKGESGNPGVRGPPGPKSGGVQYVRWGRTTCPYNATLVYKGSVGGSHYSHKAGGANYVCLPDTPKYRKYKDGVQSSRGYMYDTEYQDAQSQLFTNKNLEHHDVPCAVCYVKARSAKLIIPATYECPAGWKREYHGYLMSEDYAHSHPSEYIDIDAEAVPGTKVDVNGALLYHVEGVCGSLPCPPYVEGRELTCAVCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHG3</accession>
    <name>A0A6P8HHG3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein dimmed-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554383.1">
        <property type="nucleotide sequence ID" value="XM_031698523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHG3"/>
    <dbReference type="GeneID" id="116291351"/>
    <dbReference type="KEGG" id="aten:116291351"/>
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    <dbReference type="OrthoDB" id="5970250at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF163">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554383.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18007" checksum="92095D8656904BB9" modified="2020-12-02" version="1">MMSYEDSVVNISTAVTQATRYCTHTNTDLVKRVQDVAYSYSVESQKPKIKSSAVNSVTSVDKLHKDGSEVHRIRRHCQSNARSTRQLRRNERERGRKARLNAAFQVLKSVVPDNINAGSSDRKLTQVEILRLAKNYISKLTELLKQDNNYSFSVFNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHV8</accession>
    <name>A0A6P8HHV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trichohyalin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555959.1">
        <property type="nucleotide sequence ID" value="XM_031700099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHV8"/>
    <dbReference type="GeneID" id="116292745"/>
    <dbReference type="KEGG" id="aten:116292745"/>
    <dbReference type="InParanoid" id="A0A6P8HHV8"/>
    <dbReference type="OrthoDB" id="10402950at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555959.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="29286" checksum="0B920C778226994E" modified="2020-12-02" version="1">MAERQETDYYHMNKQSLISQLKSFKNAVKQSLNELRLKKEEIKAKTQRAQELEQEKKRLKKEVKTLSETNYELNRTIWIMKAEDELLEYDFEALEEDNEELKKKIECQIAQQKTLEEEIHVLKEEAESQHLQMKTLAHENENLKQNTDNQKIQQDLLNQENQTLKSEAQSFKNRCEMLQKEKEALKNEAESKFIQQEQIIKELTEKLNLVQNVEKVSVEVQTLTKPSNPFRRFIRRVRRVLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIB9</accession>
    <name>A0A6P8HIB9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116292421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555601.1">
        <property type="nucleotide sequence ID" value="XM_031699741.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HIB9">
        <property type="interactions" value="1850"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292421"/>
    <dbReference type="InParanoid" id="A0A6P8HIB9"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="786"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031555601.1"/>
        </source>
    </evidence>
    <sequence length="907" mass="103448" checksum="CB1CB07DC7DEF162" modified="2020-12-02" version="1">MSVQTKRLFVGGLNSGTNEKDLRERFKTFGSVSSVEVHVRPKSEGFPEKTFAYVELDASDLNIKKCITMLSNTRWKGGILKIQVAKESFLSRLQREREEIKSKGDIKNSKSSPTSSELTIAAPNSLPGTLIPGKKNWVVGKFGRVLPVVHMRQTGSHKISRIDPSKTLHNLKRIKDDAGDDKTISKLTWSLGKENDDEVIINGDKXEEDSDDTDSSSEDFXGEXKSAPKSKXKKMNSXRXXIENLDESEKXESFKEKNXKKDSPLKKYYTXEXLSVNGEGLENRELEKGESSLDDNDNVIKDDSLGNIESAEENIKSLAPXKSKKKKSKKKRRASDSSDSDQVHSIPHGSADETVVKKKPKNKVKKEDQRIDSEENSFENSEDKSILLDSKTDLKNTQNDDEKHEDLKITLDEKMNKKKEKKERKKEKKSKGGMTSENKSTTNELEVSKKKKREKENKQSYEEVKIVEPIGESNNNRKKKRAKIKEENPAKKLTSNEKRLRAAKEREASSMSKQSIIASALKNLDGNDENVKNSKHIKFDEEYEEEEQVVGEKEGKTKGKISGSKAANWLGLDSASDDDEDFPDKEVEKHLFAAKPQFEGETGQKLFKLQKSYRGDSRFQLDERFAESDDEPLPQEENDXRKPSVIYASDSDVEATIDDDISKQLSREKDLSMSVLRGILXHNIGTKYGDNTSKKDRFTDSSLIRYDPTRDDHAQFEQKLKKQDDRPEPAVNKGQQETTEVMRSVPEVTMDKFYDVKTSALSEVFGKNKSDDNTTSFKFLSDQDITENTEAXSSNWGATEELRSKPWNPVMLPYDSSGDEEEDMEHEEEQERVQTAPEESFFFHFGDPELERRVDDEESLFMRTQSLDQLNEQWIANRSDLTQDYKKKHKDALKRQSKMAAKRARMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ71</accession>
    <name>A0A6P8HJ71_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116292680 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116292680 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116292680</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555895.1">
        <property type="nucleotide sequence ID" value="XM_031700035.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031555896.1">
        <property type="nucleotide sequence ID" value="XM_031700036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ71"/>
    <dbReference type="GeneID" id="116292680"/>
    <dbReference type="KEGG" id="aten:116292680"/>
    <dbReference type="OrthoDB" id="5966951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="192"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031555896.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45533" checksum="13478C313A37A6D9" modified="2020-12-02" version="1">MAVNEKGNTVLKEGWAVKESGQAFLGKTNWKRRWCRLVKRPEGITTWSYYRKMEDIEANQPAGSIELDSTYVARELETKEEKNKPFCFALGPVFDNTAKRTYYVSCDNEEDKLSWMEVLSASIETDLFSSETFNENRRSVRSRMDRRTRKKRHQKTLSAPAQMSSKVLQVRDEYLNPSWRMEQWRCLCSVIKEAIWKKTDSKNGVTLSRLSFKHESYAVIKIEGCIPVPLEVTYDYLLTAVRPGGKFDQIFRNEEVLEVIEDSIPRASIVTNTYSLPMPSMSRRECCLLRCWIPSYLTKDNTCGLFVTSVNYPMHKPTKGSVRVQVQPSGFMLSTIENKDGSRHTLVSALGQIDLQDSLQSMLEATFKSGLLKIGLRTGFAHISNQIEKYYSLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKG5</accession>
    <name>A0A6P8HKG5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116290228</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116290228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the avidin/streptavidin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553095.1">
        <property type="nucleotide sequence ID" value="XM_031697235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKG5"/>
    <dbReference type="GeneID" id="116290228"/>
    <dbReference type="KEGG" id="aten:116290228"/>
    <dbReference type="InParanoid" id="A0A6P8HKG5"/>
    <dbReference type="OrthoDB" id="2821340at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.30">
        <property type="entry name" value="Avidin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005469">
        <property type="entry name" value="Avidin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036896">
        <property type="entry name" value="Avidin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005468">
        <property type="entry name" value="Avidin/str"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051764">
        <property type="entry name" value="Avidin/Streptavidin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34399:SF3">
        <property type="entry name" value="AVID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34399">
        <property type="entry name" value="AVIDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01382">
        <property type="entry name" value="Avidin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00709">
        <property type="entry name" value="AVIDIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50876">
        <property type="entry name" value="Avidin/streptavidin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51326">
        <property type="entry name" value="AVIDIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028057492" evidence="9">
        <location>
            <begin position="19"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031553095.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37554" checksum="84DE7BE553F4465F" modified="2020-12-02" version="1">MLGFVAVLLLTCLARGWCEKCNDLDGFWYNQLGSEIFLRHSSDGKLIGEYRSAVESFEHPDGKKHSIISGAAPYNSPGATFSFAVTWSNGSSTKAWTGQCLVCEDGKEMLLTSWLKRSQAYTCIDKWKSTMIGLDTFTRTEQLPGPRKPDKTIPSFPTGFAPTNTSGKPCDITGTWYNELGSEVILNQYANGIIVGEYRTAVERKKGSAGESHSKVYGISTPGNPNSTFAIMVVWRGGASVTGWVGQCHICGENKTEIIETTWLLRSKLEKCGDNWKSTMYGENSFTREEQKEGPRKHLGTHTPDRDGEDADPRASAKLTNEGLILWILSFWYAMFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMK6</accession>
    <name>A0A6P8HMK6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031557589.1">
        <property type="nucleotide sequence ID" value="XM_031701729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMK6"/>
    <dbReference type="FunCoup" id="A0A6P8HMK6">
        <property type="interactions" value="2034"/>
    </dbReference>
    <dbReference type="GeneID" id="116294180"/>
    <dbReference type="KEGG" id="aten:116294180"/>
    <dbReference type="InParanoid" id="A0A6P8HMK6"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000002">
        <property type="entry name" value="Possible thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="10">
        <location>
            <begin position="37"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557589.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36677" checksum="06D89F062C7CE54D" modified="2020-12-02" version="1">MLTAEVMPVENNKTKSTVKDLQEAKKVKATKKHDELQYLEMIRHIMDNGIVKSDRTGTGTKSIFGAQMRFSLRDGIFPLLTTKRVFWRAVAEELLWFVQGCTNGNKLSEKNVHIWDANGSRAFLDKQGLTEREEGDLGPVYGFQWRHFGAKYVDMHTDYTGQGVDQLAQVIHKIKTNPDDRRIIMSAWNPVDLPLMALPPCHSFVQFYVANGELSCQLYQRSGDMGLGVPFNIASYSLLTYMIAHVCELKPGDFVHTLGDAHVYLNHFDALEEQLKREPRPFPTFKIKREVKDINDFKFEDFEIMDYKPHPKIKMEMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMM0</accession>
    <name>A0A6P8HMM0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="11">ATase</shortName>
            <ecNumber evidence="3 11">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116293641</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:14907"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 11"/>
    <dbReference type="RefSeq" id="XP_031556956.1">
        <property type="nucleotide sequence ID" value="XM_031701096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMM0"/>
    <dbReference type="FunCoup" id="A0A6P8HMM0">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="GeneID" id="116293641"/>
    <dbReference type="KEGG" id="aten:116293641"/>
    <dbReference type="InParanoid" id="A0A6P8HMM0"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="14"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031556956.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="55902" checksum="9C12A4FEE5D6BB9B" modified="2020-12-02" version="1">MADKYDERKLQKACGVFACVTAEGISEADADVANTICLGLVGLQHRGQESAGIVTNCGNEFYSHKGMGLVSNVFGEVELKKLKGNMGIGHTRYSTAGSSELINCQPFVVDTIYSHIAVAHNGELINAKSVRDKLLRQGMGLSTSSDSEVITQLLTARPPCGEPEGPDWVARIKYLTNQTQCSYSLVIMTKDCVYAVRDPYGNRPLCIGMLKRTCSSYSPQLKRFNSLSDVQSRLHSQDEVLSWIASSESCSFPSIGAVLMYEVNPGEIVQLTPKGPKSLGIIPPAKTDDLPAFCIFEYVYFARADSMFEGQMVYSARQRSGIQLAIEAPVEAEVVSTIPESATPAALGFSLQSGIPYIEVLTKNRYVGRTFIQPSNRLRKLGVNKKFGPLSENFRGKRVVLVDDSIVRGNTIGPIIKLLKQAGAKEVHIRIASPPLKYPCYMGVNIPTREELIANKLSPEELASQVGADSLMYLSVEGLVNAIQSGITLQKERKIGHCTACLTGKYPVELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN14</accession>
    <name>A0A6P8HN14_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Receptor-type tyrosine-protein phosphatase F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554047.1">
        <property type="nucleotide sequence ID" value="XM_031698187.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116291069"/>
    <dbReference type="InParanoid" id="A0A6P8HN14"/>
    <dbReference type="OrthoDB" id="6138780at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="54"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="319"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="416"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="11">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554047.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="71279" checksum="C031E6320B620F25" modified="2020-12-02" version="1">MSGDKEFIGNSDRSTVVTNAISNPFRARFVRVLPTEYERWKMLRVDFKGLPLGCTSSLGLENSQIPDSQITSSSFWTSNGVQYTARLGRLYGSSSWCSPKRNPTEHIQVDLGQVKTVTGIATQGSIPVKVWVTSYKVSYSFDNRYWNEYKEGQVVENLEGNSDSNGVRVNWFRNPIAVRYIRIIPQTHNSGGGHCLRFDVYGCDIFVAPKVVLDTVDFILPSIKGSSITLTCSVLGEPAPDIQWFNNGTKINGATQSTLQVQFISAEDVVSKYNCTRQDPNTRAVVCNTFYTCKATYPNYVPSGGMNEASGKVTVNLNVPKPPTFCGTASERSIXLRWIAPTPTDDXGQIXWYGIKLKNQSSNPLIYVRGTSSSYNLAYLKPYTNYSVEMRAISVVGYGLWSRLQIIRTSITKPYNPTHVQAEKQTKTSIKVRWKSSLPISLVVKEYMIEVKGSKPYWPKYSFSKTYXQNGALTNMVIDSLVPGTSYEFWVTALTVCGKSQKSESSKKDTDIDNPVKPTGNSITLKNKFDVPLWSVDPVNGPISSYQVIVIKGNKDVSDLPTNISDYKDAQEFYVTXELKPNEIKSSFPVGDNKIYGQYKNVPLDKXKTYTIAERAITEHEGKIYAGQAAVVARIEVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQJ7</accession>
    <name>A0A6P8HQJ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116295079</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116295079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558654.1">
        <property type="nucleotide sequence ID" value="XM_031702794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295079"/>
    <dbReference type="KEGG" id="aten:116295079"/>
    <dbReference type="InParanoid" id="A0A6P8HQJ7"/>
    <dbReference type="OrthoDB" id="5971203at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558654.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20556" checksum="22F02C92A2B9B907" modified="2020-12-02" version="1">XVTVGHSCRHLQAIGRQRGIEYPSGVYTINPSGQGIVKTYCDMTRNGGGWTLLLTSHTNTWTSSNVRRRAEDNPALDRDFSILFAANAIKSATNVIGSSFEYRIEAQQFGRWGGIWKAPRSYSFTATNNKQTQVKLVQKFDQWVYEDLGIEKRMPWIHDAMLTTSHNATNQVYSYGSIIGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSG8</accession>
    <name>A0A6P8HSG8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">FMRFamide-activated amiloride-sensitive sodium channel-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116294645</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558143.1">
        <property type="nucleotide sequence ID" value="XM_031702283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSG8"/>
    <dbReference type="GeneID" id="116294645"/>
    <dbReference type="KEGG" id="aten:116294645"/>
    <dbReference type="InParanoid" id="A0A6P8HSG8"/>
    <dbReference type="OrthoDB" id="5988271at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558143.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11654" checksum="F771195FD76AFBB6" modified="2020-12-02" version="1">MMIISLPLYIWILQKRLNETLKRDNMTGMTDTEIRDNLIELHVYYADLDYAHVEETPKYEFQDIISNVGGQLGMWIGVSALSIAEVIELFIIVFNFLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSR9</accession>
    <name>A0A6P8HSR9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Synaptosomal-associated protein 47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Synaptosomal-associated 47 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116295669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559429.1">
        <property type="nucleotide sequence ID" value="XM_031703569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSR9"/>
    <dbReference type="FunCoup" id="A0A6P8HSR9">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="GeneID" id="116295669"/>
    <dbReference type="KEGG" id="aten:116295669"/>
    <dbReference type="InParanoid" id="A0A6P8HSR9"/>
    <dbReference type="OrthoDB" id="10009801at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF1">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="346"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031559429.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44863" checksum="DBFD933E0DE29498" modified="2020-12-02" version="1">MASIGKWKASYYCDSKRSWIPGIFQVCPQFIRFTEEIPKSTNDIIDLTINFDEFVELKKETTAIFYTALTIRCTNNKYWFASFPSCSHVYNILEHFWRERLLSGNDSSAQQGSGGQKLLEILHDSANCLSSTSKTLETQGQQIDNACRTMNKLHNDLRVAETIISSMDSWLNQWDLHVPEVVINVPKQGSEMEKMELPVLYAASEKEKHISGSLVLSSKVLEILDIQRNPVYSFTAREVSEVRVHTPFEMTLIKSEIGKPEVCVHLISAKLIKVMPHINVMLGPKLNFDEPPDSVAMTTASSHNDTDELLANLKLDEIEKQKKMQKASSAMGNRGAKTVSETEAAQMTKILQDMKSMAVGIQDEQNRQLGMLDLLSDSVDKANERIRKDARTIKRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT60</accession>
    <name>A0A6P8HT60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17">Zinc finger protein 845-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC116295054</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16 17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558621.1">
        <property type="nucleotide sequence ID" value="XM_031702761.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558622.1">
        <property type="nucleotide sequence ID" value="XM_031702762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295054"/>
    <dbReference type="KEGG" id="aten:116295054"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000646">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001197">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001116">
        <property type="entry name" value="Zinc finger protein 562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="719"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="747"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1062"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1062"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1089"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1132"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031558621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031558622.1"/>
        </source>
    </evidence>
    <sequence length="1292" mass="144830" checksum="8540B5D918E5C9DD" modified="2020-12-02" version="1">MSTDQEQLCVVDSDTGQILYYFNSTTGEMKWVNQPPKEISEQTSKQPVESDCSSDPEEISQEPEITTSNKDSSFTAEFKSETIEPKECSNLLSGEVVTVFLEPCPENVKKCHSATSKLQVAMTPEAAKAVASESAKSNEKKNTPRKRKLQSKDDTYFNASKRMSVRKEFLGIREFVCKICKKSFPGKEHLLNHFESHVASRPYKCPRCYKRFSDPSGLARHTHTHIIAKPYLCGQCDKSFSDENSLTIHVALHEGLKPFSCQFCNKSFTHCKALALHMVLHMKQQPCRCNYCQETCSNPKELSRHLLLHIRPSSVDQAKIVNQDTRSLSCKFCTERFQDQKTLEIHSIKKHSNEIKGDQHNNVNPLRQLQALIFKETPTYEANRVNEMRVVHLAPTDANTKSTHLTNGNEHSKKGLSGNQGSADPIKQLHELTYRRESPVNQFRITPHSSAHTGNDRPATHLKNTGGVKHLNAVKIELRNDATEERQXEPLKEEDDDLPSCHDDTKPMYIAAADKKLLPCLSCEETFSNSVDLALHARVHNDSELIQCTQCDRNFLSESQFREHLSAHESKTGQFDCPKCGKRFVLAHGLTLHMRIHTGEKPFQCKHCLKSFAHSGNLTVHLRTHTGEKPFKCEFCHQAFNHSSNLKNHMRLHTGEKPYQCKHCDRSFSRSSHLRNHIINHSLGKSEPDYYRCDICDKSFDDLAILNEHIKTHSETKPHVCRYCGKAFTVPSGLAVHVRTHTGEKPYKCKYCDRAFSHSSNLKVHVRTHTGEKPYHCNVCNTTFARSSDLRRHVYFQGCQKLFSSTSGAVQSPDGSGTITTSAGLNVHPHSYAPNINKQEIAQETSPGITPFQRIKEHIKAISENSSASVENDMMGNGNTARENLYTSSITEAARLIKAKEGVISEHQIPSQIDSQTVFEKSKESFPLVSSVYHQSSLEQHDESMLKISQPPPFLLSTLALKPTSSNSCGSDGKFQPKICYEHQKITAFDKKQNEQNDKVNKINKKASLSEESEGNRDEECNAEPIENMTSTANEMPKRKGPIKETLLKLNTVSIIKAKTLVSTTESEQPIGETSRNLEKVCTPGGTGKNSSAKTDNIHPSSPSMLETNNPSQNPFSGQQVKHVDPDRHTQSTRYPSSHSTKQPVQHAIPTREPLPGKPVLITNPTRHTLPPRHPVQPADPDRHPVPGQQPQTTDPNRHPFPGQPPQPTVPARHPLPGQPTQTTDPARQSLPGQPPQPTVPARHPLPDQPTQTTDPARQSLPGQPEGNDIIFETSSLQPLQALTERILPKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTA9</accession>
    <name>A0A6P8HTA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116294915</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558468.1">
        <property type="nucleotide sequence ID" value="XM_031702608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTA9"/>
    <dbReference type="GeneID" id="116294915"/>
    <dbReference type="KEGG" id="aten:116294915"/>
    <dbReference type="InParanoid" id="A0A6P8HTA9"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558468.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22337" checksum="D05C38302146D3AE" modified="2020-12-02" version="1">MGCLCPGHKAQVTHTYFLFTNNDIVRLANLSDAGSIYRIHTSAIREICSKCYKEEEVEHWIERQSENRYVDFIEKGDILVAEDGEGRVLGFGHLSDNEEECSRGNSTTDMKQDGWKFGVIRALYVHPDHVKQKVGQTLLKCMEDKTKEKHAKELVVYSTVNAISFYERFGFRLVGKTKQCGQGVNLQCTKLLKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU17</accession>
    <name>A0A6P8HU17_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116295134</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 14">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558738.1">
        <property type="nucleotide sequence ID" value="XM_031702878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU17"/>
    <dbReference type="FunCoup" id="A0A6P8HU17">
        <property type="interactions" value="1729"/>
    </dbReference>
    <dbReference type="GeneID" id="116295134"/>
    <dbReference type="KEGG" id="aten:116295134"/>
    <dbReference type="InParanoid" id="A0A6P8HU17"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031558738.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12515" checksum="72EC1AE2E463DEA5" modified="2020-12-02" version="1">MLLFCPTCANVLIVEEGSGCSSYRFACQTCPYVYNITKKISNRKYPKLKEVDDVLGGKNAWENVDSTEERCPKCEHDRAYFMQIQTRSADEPMTTFYKCCKCGNRWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU25</accession>
    <name>A0A6P8HU25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556210.1">
        <property type="nucleotide sequence ID" value="XM_031700350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU25"/>
    <dbReference type="FunCoup" id="A0A6P8HU25">
        <property type="interactions" value="2156"/>
    </dbReference>
    <dbReference type="GeneID" id="116292980"/>
    <dbReference type="KEGG" id="aten:116292980"/>
    <dbReference type="InParanoid" id="A0A6P8HU25"/>
    <dbReference type="OrthoDB" id="5979787at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556210.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42843" checksum="3524B744BD508243" modified="2020-12-02" version="1">MEGIRNLSTGEFLIPNNASLANDLSSSSIISRVGKILACSVVLVISFVGNILLILVVHKNANMKKTINYFIVNMAVSDLVVPIVILPRVIVQEASGRQTWLAMEGAAGNIMCKLMFFFSDVTMVVSILSLLCISMDRFCAVVFPMKLSLITSRVRIGLMAFTWTFSVFYFAPFLYGFKLMKINGETHCLLQWSEDISFHLEIQRAAAIASCILFTLVPCVLLTVMYSAILIVTRSTIIKGENGNGARSRRQANNIKLLKLAVLTVVGFAFCYGPFNVFLFYATLILNWNISTSEALRTFLFAAQFLTYTNSALNPCLYFIFIENYRRGLQRVLKIGRPKTRKNTLLASRNTTRSRLDRKSPNQTSTEDQEIRYAHLKPADSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU65</accession>
    <name>A0A6P8HU65_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116295309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031558951.1">
        <property type="nucleotide sequence ID" value="XM_031703091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295309"/>
    <dbReference type="KEGG" id="aten:116295309"/>
    <dbReference type="InParanoid" id="A0A6P8HU65"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000002">
        <property type="entry name" value="Ferritin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027621111" description="Ferritin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="8">
        <location>
            <begin position="61"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558951.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25670" checksum="27F7257D3F92F09D" modified="2020-12-02" version="1">MANSFFALFSIILVFIVVNEVKSAGVCNLADHLRNQTKXSINPPQNIYGNATVSKSLAWTWGNSASIEEKINQQINAELYAHYNYLSMAXHFDRDDIMLPGFAKFFRESAEEEHKHALMFMEYLNRRGGRVKLNPIMAPCNDQWGNGRMAMSEALELEKEINQHLIDLHSVASGINDFQMMDFIESNFLNEQIESIKELANYINTLNRIGDGLGEYQFDKITLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUS6</accession>
    <name>A0A6P8HUS6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556415.1">
        <property type="nucleotide sequence ID" value="XM_031700555.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUS6">
        <property type="interactions" value="708"/>
    </dbReference>
    <dbReference type="GeneID" id="116293161"/>
    <dbReference type="KEGG" id="aten:116293161"/>
    <dbReference type="InParanoid" id="A0A6P8HUS6"/>
    <dbReference type="OrthoDB" id="6021576at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556415.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33877" checksum="76C04AC4A095C523" modified="2020-12-02" version="1">MVEYINRSPATIAVETSIFVLIGLIAIGGNLLVVISIYRNPSLRTITNYFVLSLAVSDILYPVTALPLTIVWSVESSSIPXKXXCVFQAIASFGLLXVSVTTMVVMAVNRFVCVCKPQKYKIVFSKKKSLVIIGXVWIINFTLMTINFNEQVLHRADFEPNKIWCGLVLARKTXITXIXIXVVLVVILVVPFSIIFYCYFKVFEKIREHKKNVAPASNPNNLGTSVQEIKVTRTMFTVLIGYXATWIPVLVIVLVSIHTRVPREGHMMVTYXVASSSAINPVIYGVMNTAFRXEYKKIIKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVZ3</accession>
    <name>A0A6P8HVZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formin-like protein 20 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Formin-like protein 20 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116295751</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559522.1">
        <property type="nucleotide sequence ID" value="XM_031703662.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559523.1">
        <property type="nucleotide sequence ID" value="XM_031703663.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116295751"/>
    <dbReference type="OrthoDB" id="10044490at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
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        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="600"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="178"/>
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            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="216"/>
            <end position="231"/>
        </location>
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        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
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            <begin position="280"/>
            <end position="299"/>
        </location>
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        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031559522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031559523.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="77262" checksum="DF6DFD466578C8D0" modified="2020-12-02" version="1">MAKLGDDVLEWQTDQLVEWLQQEEMNDCIKPFTTRKMNGRSLVNLSELEIKALHHVSNDSKKKLIRSIEKFKRRKKEKMAAMFGNQKLVQTVNTRKPPSFCQEDDAGSDDDGWGTDEWDSDGSQDASSDGDYLEPEEDLSKTGSLGREAVSVPTGLVAQLRAGIASSLTRSHKAPQQSYQDDEDIYDEPPEEEELYDEPSDSSGGAVVVRPPKKPPKQEDKGEYLLPREMDGDQDVYEAPLEEEEEISPRPPARPSKANRFIPTQVVQGNKFVPIRSSIDNDENETYEIPELEDQEDSYEIPGEQTXPPPRPPKKFSAPVNTPLKQAKQSKPFPPQKPQVSPGKPSFKVPSPQPSNQTQGATRRFPGTSAQQSSLSPQGTPFRTQPPPPAQTKFQPPLGRKPTPEPKKTEFGGYPGRQERSPPPSPVKSTGASIAPVPGPRAGILSKSEPRPSPRGSPLPPAAHRKQAPLPTERPPPPEPRATPGVEPVPPNHRGLPSVPSPQMTEPVPPRPPKIGHPAGXPQPMLPPRQGVPLPAPPSAPSSLRDQREQSSASSIESTSADEPVISLQHLPKPGKRSLPPTPTVDSKKSSLELMKEAPWFQGPVERKAVEESLKQFNQNGAFLVRNSTKSPNDYSMSLIYNGNVRHLRIPHKNNKYVLGDSGIQQFDSIIDLVNHYRQNEVDLKKGGKTKLTIACQVYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWB0</accession>
    <name>A0A6P8HWB0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116295844</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559658.1">
        <property type="nucleotide sequence ID" value="XM_031703798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295844"/>
    <dbReference type="KEGG" id="aten:116295844"/>
    <dbReference type="InParanoid" id="A0A6P8HWB0"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027695911" description="Reticulocalbin-3" evidence="13">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031559658.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38294" checksum="0E4FB68153877561" modified="2020-12-02" version="1">MKLLLGLFLALFICSTVVLAKPNDKEGRVHDGKLSDKEHFSSSTGKHNQEXDHDAFLGSEKKTFDKLTPKESKRRLGLIVERIDKNKDGKVSRDELVEWIRFAGKRWLYDDNDRLWNHLKKRETYMLKYLGDKMNPDAQADPEAPIGWEVWKMDVFGEEVTADEEERFYHDKKLWEAADVDKDEKISKDEFGAVIHPHQFAHMKHLVLEDTMKQLDTDKDGYVSLDEYIGKGFSMSFFADILKHNRVKDGKDKEELIKSERKNFVNDRDKDKDGRLKKEEVAEYIFPSYDHSTAEAEHLISHADKNKVRMIFQARLPRARFHSVPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWF8</accession>
    <name>A0A6P8HWF8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1 family domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556995.1">
        <property type="nucleotide sequence ID" value="XM_031701135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWF8"/>
    <dbReference type="FunCoup" id="A0A6P8HWF8">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="GeneID" id="116293671"/>
    <dbReference type="KEGG" id="aten:116293671"/>
    <dbReference type="InParanoid" id="A0A6P8HWF8"/>
    <dbReference type="OrthoDB" id="549905at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556995.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="74779" checksum="70B393617635AC6A" modified="2020-12-02" version="1">MAAGVSLNKNISSVWQKILTTVNNALVYMDNPAAEMLHWSGNVKNMVEAGALAIIDLSSKRSGNESETKAVFIVTSVVHGQTLKDISTIIQSSDFQHCTLLCTVPETVNSFVKHNDNMEGSVFGELSLKMREWMGNPYSTVDIHHVALFASQLYPGLFFTPAFAHFFPILPCDTSRLQGFLRSTVGDKSHVFNCLSEVEMGLLPHNLQVKIKMFAAGLSSMFEIMDINEDCYGLGYISKLVASELANMPSARGRRKTASRRASLVLIDRTLDLVGPCVHTGDTLADKIINLLPRLPYHEVDVAVDMARLCASGSVTPDTVVPGSLAHANDPVAQVLLNSLFTKRQKEGLKDISRHLIDAVSKESLPLETKGLPSKVTPEHLQTLAEQFRGQPKAFHKHSALLQITMATINALQHKDSKSLQKLQAIEKILLSSALTEDSHNVIQEILALLETPKEDNSYSLEDIMLLLTFVFSLMGDEFYESPAEIEKLKNRIVDCLLSGNLTCDTPGYLGNEITEKTSRRKVSDAFEKLSGVGIAREELKQHRSLYQDETALEEASYNPLVKQIIDAIFSDDKPELIDIEFKSHGLKDYIKTGFSLFMNVSKPRPNGLPFLVLFVIGGITCSEVQQIREALAAHRCNIQVIIGSTQILKPGDIFQRVFCQENLFPPLTNEEYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX75</accession>
    <name>A0A6P8HX75_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Importin-11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ran-binding protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116293839</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with UBE2E3 and RPL12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557187.1">
        <property type="nucleotide sequence ID" value="XM_031701327.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HX75">
        <property type="interactions" value="3284"/>
    </dbReference>
    <dbReference type="GeneID" id="116293839"/>
    <dbReference type="KEGG" id="aten:116293839"/>
    <dbReference type="InParanoid" id="A0A6P8HX75"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000116">
        <property type="entry name" value="importin-11 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557187.1"/>
        </source>
    </evidence>
    <sequence length="970" mass="111410" checksum="4997B679707BA760" modified="2020-12-02" version="1">MEESGVVGIEAIFETLQHACSQNPELLKPAEQRLHSWETRHGFYTALMHIFSNRSMDANIRWLAILYIKNGVDRYWRKNAPKAIPEEEKAMMRHQLILSLDEPVHQIATQVAVLISKIARLELHSWPELFPALFEGVQNPSFLVKHRSLLVLNHVTKMLSSKRLANDRQLFRQLSESIYASILDLWEAHSTLCFEKVHQQASNIEESLELSILLVKVLRKLTVHGHRGFTPDSKPMVFLSTSFDKIRLFLECRRQLGHSQKLNEMVEKIAKLLSKSLLDSLDHHPSSFIPLVQKSLEFCVTYLFNSEAAGLGFELFLVQCCNIVRAILRCDVYRPPKEIKESTPQETIAVHQVKMSFFTPSVLTEIIQRLVMHFFLLKEEELENWESDPEDFVNEEVGESWRYQLRPSTEVLYLTLFAEFRTIVTPVVVNMIHTVQVSPDSEDMNFLLQKDAVYTAAGLASYDLFGEVDFDAWFKDYLLREMHTTSSRTKLLRRRVPWLVGQWVNVKMSASVRPLIYESLIYLMQEHEDLVVRLTAANTMKTVVDDVEFHLDDFEPFINGSFTSLFHLLRQVSECDTKMHVLHVLSTLIERVDSKVRPFAGLLTMYLPHLWDESEQHNMLRCAILATLNHLIQGLGTESVSLYPFLLPIIQLSTDITQPPHVYLLEDGLELWQKTIENANKLTPELLHLFSNMPALMEISSENLRTCFGIXDRYLLLDGKEFLKNFGTSVVRSCENMVGNIKPEGGIIIAKVIETIVKSFPVEGVQLLQPVLIKMFKLIFEEEEHTPLLVIYLCIFGEIILKNPSYFSDFIEMMAGMSHAQSVDLLGQFLDVCLDKLDSMTRLERRKLMVMALSSLLPVNSKCVTERFAVILDAVVDVLHEIHRCEEGVHTDCLVLFTDEDVPNDESESENQLRKKKLTLSDPVHRIPLWQFVGAKLKESQSAHGDVVFQSCMECLDSAVAEQLFSFINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXY7</accession>
    <name>A0A6P8HXY7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294075</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557467.1">
        <property type="nucleotide sequence ID" value="XM_031701607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXY7"/>
    <dbReference type="GeneID" id="116294075"/>
    <dbReference type="KEGG" id="aten:116294075"/>
    <dbReference type="InParanoid" id="A0A6P8HXY7"/>
    <dbReference type="OrthoDB" id="5951411at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557467.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14278" checksum="B1C0EDDBADB5064A" modified="2020-12-02" version="1">MVHTSLYRIKRKNHQDTFIKSRTRINDGLWHKVLIRRTLSTLFVQIDSGTPRKKLVDRFFLRFHPGEMLLGGFPSQAALIKGSNWPTFQGSIRELMIGGKRVDIKNEVSSQIKARLYRTSSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ73</accession>
    <name>A0A6P8HZ73_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras-related protein Rab-43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116294489</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Lipid-anchor</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557970.1">
        <property type="nucleotide sequence ID" value="XM_031702110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ73"/>
    <dbReference type="FunCoup" id="A0A6P8HZ73">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="GeneID" id="116294489"/>
    <dbReference type="KEGG" id="aten:116294489"/>
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    <dbReference type="OrthoDB" id="9989112at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000803">
        <property type="entry name" value="Ras-related protein Rab-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037864"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067841"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557970.1"/>
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    </evidence>
    <sequence length="208" mass="24105" checksum="8F97DDF0CC2399B9" modified="2020-12-02" version="1">MRDFESSDSFDYLFKIVLIGDPGVGKTCLVQRFDRGTYLERHGSTIGVDFTMKTITIDEKKIKLQIWDTAGQERFRTITQSYYRNANGVIITYDITKRETFKNVARWSEDVKKYAPKNVMKILVGNKKDLHVERDVSIDEARKCAEHYNMIDAMEASAKDNIKVEEAFIHLATELKREYEKGSQVQNIEDGGVTIESRKINRKWQCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZJ0</accession>
    <name>A0A6P8HZJ0_ACTTE</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294542</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031702167.1"/>
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    <dbReference type="GeneID" id="116294542"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558027.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22003" checksum="E1EAC5E56BF4ED52" modified="2020-12-02" version="1">MALSWRSNLKSPRKQTSLSPAQTKLTSPREQLSANLSPRQDLKMVSPRDEKNIVKSRWSHLSASPPKSKSPRKEISLSQVKNKPRITADELIARKFSAEKKPVTPRQRSQVFLKAVQKFEGEIPGKLLKTEEARRNLADEQLEFCSNELVDMREFLEQIEMDFSVIRQRIEKAKEDVSDLRRSNRAFVETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0M0</accession>
    <name>A0A6P8I0M0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293951</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294881</name>
        <name evidence="3" type="synonym">LOC116293951</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557312.1">
        <property type="nucleotide sequence ID" value="XM_031701452.1"/>
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        <property type="nucleotide sequence ID" value="XM_031702565.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="116294881"/>
    <dbReference type="KEGG" id="aten:116293951"/>
    <dbReference type="KEGG" id="aten:116294881"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558425.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21056" checksum="FA13DB06ACC51DDC" modified="2020-12-02" version="1">MFKSIFSKKNRNDSLAARNEAENNAYEGSSSDSSAQQPLNEVLNQLYDTLDPSDPRGYAVAVAEVEYLWARYQQLIVRGQLVNDDILLQEPFKSKPFLRQVWNTIPRDSNGNLTFSALFGVLKWWESVDQETKLRGIFRLLNTGQPLDIAAIRHIIKAMDSSLNEDSINRKADLLMTYLDNRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0W1</accession>
    <name>A0A6P8I0W1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sodium channel modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116297297</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561368.1">
        <property type="nucleotide sequence ID" value="XM_031705508.1"/>
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    <dbReference type="FunCoup" id="A0A6P8I0W1">
        <property type="interactions" value="1349"/>
    </dbReference>
    <dbReference type="GeneID" id="116297297"/>
    <dbReference type="KEGG" id="aten:116297297"/>
    <dbReference type="InParanoid" id="A0A6P8I0W1"/>
    <dbReference type="OrthoDB" id="1924550at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033570">
        <property type="entry name" value="SCNM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031625">
        <property type="entry name" value="SCNM1_acidic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031622">
        <property type="entry name" value="Znf-SCNM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32297">
        <property type="entry name" value="SODIUM CHANNEL MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32297:SF1">
        <property type="entry name" value="SODIUM CHANNEL MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15805">
        <property type="entry name" value="SCNM1_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15803">
        <property type="entry name" value="zf-SCNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Sodium channel modifier 1 zinc-finger" evidence="13">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium channel modifier 1 acidic C-terminal" evidence="14">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031561368.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35680" checksum="917B15A22D366D90" modified="2020-12-02" version="1">MSFKRVADDFDDFKLQKKRRVNDLLLESIPSDEAILMKNGKLACLVCSHRPIFDTTAMLSIHRNGKKHLANSLIKLERAREDAEIRQKREQESFLKTRQDLAENPLLGLTQMKKEQALNESSLKNPSLNESASGVGRDLMCNQDTNTSKPFFGKSTSFGLEKSSSSSTSSCVNRKASGLKYNXPDVSKKANPKRERFLSVNPLTKQNNPQGIEFNPVCNNGRNMEDTELNQSNTTTFSTSQTNDLTISNKANPSTFFSHGQHSTLNHLDANSKAQYLSKLRQIGWILGTDGKWEKDENAEFESDEDEPPSPRTMLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I175</accession>
    <name>A0A6P8I175_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PITH domain-containing protein CG6153-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558630.1">
        <property type="nucleotide sequence ID" value="XM_031702770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I175"/>
    <dbReference type="FunCoup" id="A0A6P8I175">
        <property type="interactions" value="2851"/>
    </dbReference>
    <dbReference type="GeneID" id="116295059"/>
    <dbReference type="KEGG" id="aten:116295059"/>
    <dbReference type="InParanoid" id="A0A6P8I175"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000002">
        <property type="entry name" value="PITH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558630.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24264" checksum="5F725B56E19B2A6D" modified="2020-12-02" version="1">MAGCGGDHHHHHHDHDHVHDDPSERGSQYSLYQKIDMFRLQCLNEAEEESGKNVFKPWDKRLDLTKFVESDVDEELLFNIPFTGQIKLKAFVVIGGTDGDHPSEVRLFKNRPFMTFDDAKAEADQTFELHKDHDGSLEYSTKIARFSSVNHLSMYFPKNFGAETSKIYFIGLKGDFQEAYRHEVTVCTYEARANPADHKTNAMDSVNHMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2R1</accession>
    <name>A0A6P8I2R1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116295500</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559187.1">
        <property type="nucleotide sequence ID" value="XM_031703327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2R1"/>
    <dbReference type="GeneID" id="116295500"/>
    <dbReference type="KEGG" id="aten:116295500"/>
    <dbReference type="InParanoid" id="A0A6P8I2R1"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000138">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="53"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="268"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031559187.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56276" checksum="2A221F5168A57E13" modified="2020-12-02" version="1">MAREELKELKQVFKAEMTIMTAPAFLTCLTLVVFFGCFHSSVSLASRAGANASHVLKDLLDSTFYDKRLRPNFEGDPVEVSLNVFLTSIGGLDEKEMQFETTFFLRQTWKDSRLAFGDAYKVRNFSISGDIMDQIWKPDTYINNEKSSFAPPKQFLLQLFPDGKVLYSQRMTVLAACMMDLHNYPMDKQRCSIAFESYGMTTHDLILSWASEPYKKSVGVADGVTLSQFALDEYTAEKSLANYTTGSFTILKVTFLIRRKKFYYVVQTYIPTILITILSWVSFWIPRSSPPARVALGITTVLALTTLIFGIQSSMPKVSYVKAIDWFLMISFSFVFAALIEYPSSTFIKFQAEKISKTGTTILRKVKGENVVNSADDLTMNTTSYGHTNHAKELEGDLSEDNAEEKHGFRKTTRFNGVSDVSNPRDYELNDEGLRHRKQKERDMESFKENFTDSEVTNVVDKYARIIFPLSYLLYNVGYWIVYLLEIDLLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2V6</accession>
    <name>A0A6P8I2V6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116297977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP91 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562158.1">
        <property type="nucleotide sequence ID" value="XM_031706298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2V6"/>
    <dbReference type="FunCoup" id="A0A6P8I2V6">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="GeneID" id="116297977"/>
    <dbReference type="KEGG" id="aten:116297977"/>
    <dbReference type="InParanoid" id="A0A6P8I2V6"/>
    <dbReference type="OrthoDB" id="567787at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026720">
        <property type="entry name" value="CFAP91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032840">
        <property type="entry name" value="CFAP91_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455:SF10">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14738">
        <property type="entry name" value="CFAP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP91" evidence="9">
        <location>
            <begin position="174"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="708"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="268"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="751"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562158.1"/>
        </source>
    </evidence>
    <sequence length="826" mass="95429" checksum="1F0AEC1547EF1549" modified="2020-12-02" version="1">MSTTHTVTRTRVQPARTHDYLYDNIHTLSSDRDHARATFKAHTGTDRVKRVPHYQTMFSDLSHYPRYSVHLEATDPVPKFIPRQWRGYSEQAREALARYTKFNYDPSVQVPPKSFPVTDVGGKDRYKFFKRPIIPFLQQVPPDVLLQTSRTDPLSSHDLEKERPPTPATRTVMVQTDYRDSEAQTDPYTPEYVVRPGSQPELLTLATLSYGHGLPAGLAEVEMIERARAKRLWESTLPSLNDMENLEKRRRMMDEQERREWSFREQEIEKLQEARLQVLQEILQQREEDHAEINAKRLDRLWSDKQQEKESKFHKLKTEHAKMLRKLKEKRKNVEGKLERRNIVKDYSTNGSQTFAPMSRVGVFLDRGSEQYNVQSFHLSTYQGLLELEASLPDFVTQPRVQAPKPKSGAKAGFVKRTQRRQKELEQVADIIEKAKRPVEVEKPLKFLVKVEKPVPRPPTPSVPVPSQVEEEAELAIIYLQKIIRGRAIQNMMFEGKEKRLELIQELRSTHALQEAGQMEKRNERQAVLSLQRQRRLDQHKNSFEEEALAQMEGSTLADMFDFLSKELVRLQEERRIHAFAMVAERQRRMREAEESGRRQVEERRRREEDEVFKQVVNVHQNTVDTYLEDIILAAIDITAHEQAREEIQEQAEKINKIAYDVEKTRTKLQSEEIVAELVTSFLLPEVQKITVREKVKRNQRKHLLAAHKIIHGEVEPIMDQQPQPEPPKEEPKPEPEPEKQADTDKPPSRPSSRPSSRPSSAKSHKSGSGSPKPQSRSGSPKSSRAGSPKSKSSSRPSSSKSRPASGTSRRSSQPSSVTSEKTEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3L7</accession>
    <name>A0A6P8I3L7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tachykinin-like peptides receptor 86C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563149.1">
        <property type="nucleotide sequence ID" value="XM_031707289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3L7"/>
    <dbReference type="GeneID" id="116298747"/>
    <dbReference type="KEGG" id="aten:116298747"/>
    <dbReference type="InParanoid" id="A0A6P8I3L7"/>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="62"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563149.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42688" checksum="9AD9672A525C6DDB" modified="2020-12-02" version="1">MLVLSGTFSSIMQLESLNHTPNFSISAANSVLMCPVPTPDSTASNIAKTIAYGLIFLLSIVGNSFILLIIYKEKDLRSTTNFLIANMSVSDLLASVFFMPIAILEIHNGHRSWPIVGLTGSILCKLVYFIHDVSVAVSVESLTFISIDRFCGIVQPHRRKPFVGRVKKVVLFIWLNALVLHSPFLYAFQLTNYKEKSYCLMIWPTSIDSSLVNKAFFLTLIVILFVLPLGIIVVVQSLIIRKFHRQKMPRGLSCEARLRRHRRNRKVVAMVLAVIVVFFSCWSPIIVYSFIVLFKRGTCSVSVLFRFIASFIVESNKAWNFFIYLIFNNTYRRALANLFRCGKKNVYNGEISSHARQIEIEAPQALNTQEGDCLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4P3</accession>
    <name>A0A6P8I4P3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 91-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116298196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562436.1">
        <property type="nucleotide sequence ID" value="XM_031706576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298196"/>
    <dbReference type="KEGG" id="aten:116298196"/>
    <dbReference type="InParanoid" id="A0A6P8I4P3"/>
    <dbReference type="OrthoDB" id="9439254at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
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    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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    <evidence type="ECO:0000256" key="11">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50157"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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            <dbReference type="RefSeq" id="XP_031562436.1"/>
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    <sequence length="1696" mass="193811" checksum="2444B7144BFA6C21" modified="2020-12-02" version="1">MASSQEEIDNSSYQSDDHILCDDCDKLYKGHCPEHGPLEWIKSTRTVSADHFSPSVASLPDGLVIKESGIPDNDMGVFAARLIYKRTMFGPFEGVQIPSSEIRDVKNLTYSWDILQNGISNFVLDGTDEKKSNWIRYVTYARDKREQNLIAFQYQGEIFYRTFRDVYPGEELMVWYEDEYSCSLDELPQEFPQDQVPEFACQRCRLVFAGTTYIYKHHKFRCPGGPLACTYGARTTGLVGALFRLPVAIANDTWSSPVPSNNDYKPRSDESHHSRRKRKPRKLPRPSDNEEAWNPEQPFGPPPIAELNHNETDSNQNRTTMVMLPPEAKAFDAHPDFIINNEEAIEPEDYAYENYLRRLNTKDSITDYQEKRPRLDGETCVDEEDSKYPYRCNECGKSFARPVWWAKHESRCRKKYAKIKDNANHSTGTSIVVESLSSTIDQISNTKQVKPRKEPYKCGYCDKKFACPSWMRRHEKVHTKNLKTKSIATAHRKPGNEDPPHPYECVDCGRTFAVAAWLTRHRATIHPNSKAQTTKPRLQPRXHVCRDCGRGFAVAAWLTRHRMTAHKNNVSKKHFCGICGRSFAVAFWLTRHLKIHEGSEQKNADTLGVKSKPINPVVSIKSKKPMTLPWVCGQCGLSFRFESWLKRHQKNNKHTNGFYQIPKAEDIDQLLVCEREGCGKSFKTRRLLGRHRRRHLKKDKANDVTESXRQLSAPTAPPFICQYXNCGKSYSTKRMLTRHMQNHVKSEESMVVDVDAVVDSSECQFXKKVFSTKDLLNRHIKRMHGKALSALGGXESKAVLADMETKSVAKSGSKSAHTCKFCHKVFSYPLLLQRHLKRHXKNEQTRKNLTKALNIPQDAASPGVEKQSYVCEICNVSFKXLHILNKHMEKHLGEKRSSQEKASTKTAKPDPEHPYQCDQCERKFAASFWLTRHKNEHKKEEEAAAIKHSNPVDPKLPFQCEECGRGFAVAFWLTRHKREHVSLSSSEKEVDEPVPVTKGKSKVYVCDTCGKEFIWPSWLVKHRRVHKRKITEIKTLERPFKEKRIKKKKAVEKQTPVNYDGVKASKCFEMFEENGVKQYRCTICGKATVWHTGIVYHIRVHHTKEKPFKCRVCGKDFHMAGDLTKHARRHSGEKPFYCQHCKKRFTTSQQASKHAAIHSSELPFHCKHCGKRYRDRSSVWRHIAKKSCPGAQGLASTTPKVHSKEQHSPKTPIVEKKNATSKKQQIEEPKPRNQPRAQKKPLAQLAKSVQSGKXNVTNKKKTKKVSHDCKNCNKTFGQLDEFKAHIESYAKAGQIVCEYCGKCWARTADLTRHLRVHTGERPYLCPDCGLGFKVSDALKRHMLKLHPKSTKTMIRIKTEPSKTEVVDHNMLHGNATDNKKAKQISENDYQNHPSSGGRKRAQEKKTVNAVIKNTDGNLQNNSGKPSSERTSLNDSGRKRRARPKHADNLLGTSFPEYIKSHVKSNSLKECKTNENTKEGAEPKQSEDLVESSGKQLQINECETFPSNDGAALDNREHDKSSQMNESLIDISVEYPEGDSKQLLSETFNTSKNVERDQEDNSEDGSSHPLEEHREGVSEERPPGASVGKAFEKKNRKDIHSYQKQVNTDNQINVAKKEKSEEPKDRPPVTKNKRSGKSSCSNKGRRCEFCGKVFSAAGNLARHVRLHTGEKPFQCKECGESFMRTDILSQHMVKYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I545</accession>
    <name>A0A6P8I545_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116298320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562581.1">
        <property type="nucleotide sequence ID" value="XM_031706721.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298320"/>
    <dbReference type="KEGG" id="aten:116298320"/>
    <dbReference type="InParanoid" id="A0A6P8I545"/>
    <dbReference type="OrthoDB" id="5984948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Elafin-like_sf"/>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
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        <property type="entry name" value="ZP-C_dom"/>
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    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
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    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
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        <property type="match status" value="7"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="ZP_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028006679" evidence="6">
        <location>
            <begin position="20"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1223"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
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            <begin position="76"/>
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            <begin position="186"/>
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        </location>
    </feature>
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        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="419"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="679"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="8">
        <location>
            <begin position="934"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562581.1"/>
        </source>
    </evidence>
    <sequence length="1265" mass="140548" checksum="375222A9D57AB536" modified="2020-12-02" version="1">MTVILLVLFACNAFSGSFGEAREPPACPTLSVHKRCPVGLANQCAKDSDCPTFTRCCWDGCNKRCVDTTSKLAINSRTKYGGCPRHDMXNPCSANFDLCLDDSYCLGDEKCCMDADCGKKCMLPKTLAVIKNATRAFKCPRVKSHKXKCPKNPSHKCALDSECPTDTACCYDGCRRRCTDQNGELVPNRKGLSCPLFTPPVGCPVSFKECINDEDCSFSMKCCSDTCNHWCMPSLPHRVNIPDKVDPIPTDPSERNLYKQGKCPVMPKLKSCEGQVFQCNYDVDCWDSEKKCCDNGCVTACVDPVFTTTGLIATPALTTRRTTTFRTGPLVTTSTVTINPKTKSRPTTTDPLVTTFRLTTMRKTTPRPFTAEIKTPKVTRKTTPYDAFTTEKTTLKTLPPTTTTTSTTTMRTGRRNTEPKVVVTQPIFTEMKTSPPVKDGVTIYPKTDDAVVGSSVKXVCYVRGEPFEGWYDPKGLKITSTKDNSDTYVYGHGNDYTLVIDKVGEEHGGKYTCRGAFANDTYSLTIPLAVRESEIKVFLRSGATGMIKVPIQGFPRPQKYEWMKAYEPLDVNDGRYSVTLGGTLIIKDVKMSDKGKYSVSATNLYXKDNGIFTSMVAHRVDVEAXLEVIGGKCPMPKRTSCLFQAKDECVTDEECARSSSCCSDGCRKTCIQINGKNKDDAKPGYCPILLPPXKCPSSIKKCSHDNHCYGNQKCCSDSCTLRCTDPNLISPEFIPGVQIYPSSKTMCNPNKPIRFVCRIDKQPFEGWFDSYSRKILPETHGTKMQVEDHXIYQVLVIHNVTAKDGGRYVCQGALDNAAVELNVNRTIDKYDHPIILHPGKSGLILQNVKCYPIPKFVWYRRGRPIDLSSSDRYSVSPSGSLAIRRVRSIDMGLYTLKILQGGKVLDTGVRVAAAIEGVDFTEWQDSFAPGASVRCLKDTMYIDLKKNALSGYSELDLTLANSSCRATANQTHYTLKAPLMGCGTVTKFTDEAVVYSNVVKEYRRKGMITRIQDIRIPFSCFYTKEGVTSTFGLLPTKVRKILDGGNSTTKFELGMSLYRDESFSLAYGIGDFPLKVTVNRPLYVQVSIDSPDKRLSVMADRCYATPTQNPDHVMQYDIINDGCAVDPTVQFYKGSYNVQRYSFKAFQFIAQGRQFVYIHCHLIVCNASNAASRCXQGCLSSLGRLRRSVSSTTEVDLTQGPIXMENRPNALGQKSFGSSFQKYVWIMVGMGGFCIICLIIMMYMKKQISNHRKIPQPDPDRETNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I618</accession>
    <name>A0A6P8I618_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurexin-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564039.1">
        <property type="nucleotide sequence ID" value="XM_031708179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I618"/>
    <dbReference type="GeneID" id="116299519"/>
    <dbReference type="KEGG" id="aten:116299519"/>
    <dbReference type="InParanoid" id="A0A6P8I618"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564039.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35885" checksum="060EEF39D25FA9A5" modified="2020-12-02" version="1">MPGSLVLWIISYTLFITCYISELLFAQDWQLPFNGIHSQSSSYFKRIPNSCIDAQNITSSSVYTTFDCQMMCTHKPRCLSFNFGLQENKEGHHVCELFDVTKYGDSALIKTDLYDFYTVPSVPRSCSHAKSLGYDETRNYTINPDASGNADTFQVFCDMRDKDGVGVTVVSHDSENRNFVSGCEKPGCYGRDVNYDGISDVIAQLGALTKVSTHCEQYIKYECYGSMISSHAWLVSRDGSRLNYWGGAPPNSGKCACGVAENCTGGRRKCNCNINTMEWHEDFGLLSYKDDLPITMLRFGDVTPSEKGYHTLGKLKCYGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6A3</accession>
    <name>A0A6P8I6A3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116296636</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031560547.1">
        <property type="nucleotide sequence ID" value="XM_031704687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6A3"/>
    <dbReference type="GeneID" id="116296636"/>
    <dbReference type="KEGG" id="aten:116296636"/>
    <dbReference type="InParanoid" id="A0A6P8I6A3"/>
    <dbReference type="OrthoDB" id="330637at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23437">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF138">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 13" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="15">
        <location>
            <begin position="548"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031560547.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="76552" checksum="DE4F4D464194CA15" modified="2020-12-02" version="1">MKLKLHRSRQVIVVALLTSIFWFMLNIILLYTYQGNIFLSLRQGTQSREEGQANVLPGNLNGVRLPRGQTHQKQHQQEPTVLEKIPKIEESQNQENEDSNKDKDEDDKNWLKQYIGNVKSPTSSEDSDLHNADQKIKVMKEENKDSIKPKVTVKTEQVQPSRKEFDFETEPVARDPNGPGENGQAVSIKENEKKEETEGYNQHAFNELASRKISLHRSIPDTREPGCAVKKYPNDLPTTTIVICFHNEAWSTLLRTVHSVIDRSPAHLLREILLIDDYSTHDYLKSKLQAYVSSRLRKVRIIRTNKREGLIRARLIGARAAKGDVITFLDAHCETNVGWLEPLLSRIHSDRTIVAVPVIDIINAKNFRYSGTPSGVIGGFSWDMQFSWHSLPYSRQKERNDKTDPIRTPTMAGGLFSIDRKYFFESGSYDEGMDVWGGENLEMSFRIWQCGGKLEILPCSRVGHVFRTRFPYSFPGGYTEVSVNLARVVRVWMDDYKTFVYMKRPDLKTLQYGDIKSRLDLRKRLKCKGFKWYLDNIYPEQTLPGGDAKVYGEIANPSNRMCIDTMGRGMGGALGYSLCHGMGGNQLFFLTASGQLQSSDEANPVCVEAMGEEILLMGCDTNSESAQWTTMGKSIYHKARKKCLESNAKTGTFTLKTCFGSAAQEWVFSNKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7L7</accession>
    <name>A0A6P8I7L7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein FAN-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116299479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031563998.1">
        <property type="nucleotide sequence ID" value="XM_031708138.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I7L7">
        <property type="interactions" value="1666"/>
    </dbReference>
    <dbReference type="GeneID" id="116299479"/>
    <dbReference type="KEGG" id="aten:116299479"/>
    <dbReference type="InParanoid" id="A0A6P8I7L7"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="261"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="608"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="692"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="740"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="782"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="863"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031563998.1"/>
        </source>
    </evidence>
    <sequence length="898" mass="101832" checksum="BEC9AA18179549D9" modified="2020-12-02" version="1">MPFGDCWPCLAFLNIGKNAQTKGTSIAEISMSVWDKVKRRLGXVNGEGSGLSLNPEAAFAEDHYTRFSLLLLEPGEIYFEDFSVFYYPYNVPEEEAIKRRQRGRLKMCSKSILFDPIDTSFPILKFPLRECLRIAHWTGPLLSKIDTKGDVLVIESKQVIEMKEGNIVAPYRFIRVSSLTFLDFKLKMNKKIINSRYVMLIQWCPVVKCKLSQISRVVKRRYLLRHVGVEIFSSDGSQMYLVLNSQKERDTFFDELVAQQVVKLEDSGQENMTLKWQNGAISNFDYLMYLNSLSDRSFNDLTQYPVFPWILADYTSESLDLTNPATFRDLSKPIGALNESRLQQLKERCKEMPEPKFLYGSHYSTPGYVLYYLVRVAPEFMLCLQGGKFDQPDRLFNSVAETWDNVLTGHADVKELIPEFFQSSGEFLINSQGLPLGVKQDKTKVMDVELPPYAKDPEDFIRINREALECPYVSERLHNWIDLIFGYKQRGEEAWKSDNVFYYLTYEGAVDLDSITDPNERASLEAQILEFGQTPKQLFKSPHPKRMALPSSTNGVTAQNDVAIKNEEKEPRAEKIPVVNVSVDFDDSAEPELDHWGSIDKLEKASCHKLHKDTVTSVRLSKDCKHVFSVSQDTQLKIYSLEEKQQIRSINLSSMALSSCAIMPDAKTIIVGSWDNNIYIYSVEYGRVVDTLRGHDDAISCLCWNDGILVTASWDSTVKVWKFLPEPDGKKPASPLILAELDHDTEVNTVDLDPTNTLVVTGTXDGNVLLWNIDQQTILSQHHIHRETVHSVLFSPDGQRIFSCGSDHSMRVTDVQTGTEVFSKNAGEEIRCAVWDGQMVLAGGESGDLQIWDLFHVQQITSITAHKGAIRCIDVSGDGCFVVTGGEDGQVIHWKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I862</accession>
    <name>A0A6P8I862_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Nori-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">TP53-regulating kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">p53-related protein kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116300111</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031564744.1">
        <property type="nucleotide sequence ID" value="XM_031708884.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I862">
        <property type="interactions" value="1779"/>
    </dbReference>
    <dbReference type="GeneID" id="116300111"/>
    <dbReference type="KEGG" id="aten:116300111"/>
    <dbReference type="InParanoid" id="A0A6P8I862"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031564744.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26032" checksum="68681300DAFEAB45" modified="2020-12-02" version="1">MADEKEXKCVLIKQGAEAKIFSGEFYNKPVVIKERFSKSYRHPSLDEKLTCRRTAQEARALLRCRKAGIPTPCVYFLDLEKNRIVMERIQDCYTVRDRINSLLEENCDSAMGMLNDIADNIGSTLALMHNVDCIHGDLTTSNMLLKKQSKDQVITLIDFGLSSVSALPEDKGVDLYVLERAFLSTHPNTEELFKKILVTYKKLAKKADDVIRKLDEIRMRGRKRTMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8I2</accession>
    <name>A0A6P8I8I2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat and coiled-coil domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560970.1">
        <property type="nucleotide sequence ID" value="XM_031705110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8I2"/>
    <dbReference type="GeneID" id="116296977"/>
    <dbReference type="KEGG" id="aten:116296977"/>
    <dbReference type="InParanoid" id="A0A6P8I8I2"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560970.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9795" checksum="F38E2181955A51A9" modified="2020-12-02" version="1">MREADDAFRHQLHAERQANEQQMIRIVKEKEDELERANKKVLEVEDEMRQLLQENAVTRKTLEMRIKKLTSAFTEIQQDLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAW5</accession>
    <name>A0A6P8IAW5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116297712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561855.1">
        <property type="nucleotide sequence ID" value="XM_031705995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAW5"/>
    <dbReference type="GeneID" id="116297712"/>
    <dbReference type="KEGG" id="aten:116297712"/>
    <dbReference type="InParanoid" id="A0A6P8IAW5"/>
    <dbReference type="OrthoDB" id="5981648at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031561855.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30730" checksum="B7B3723CBC78518C" modified="2020-12-02" version="1">MLFRLNNPEGLVQIDSLTITDLSLHDLRSAISIIPQDPVLFSGTLRKNLDPFGSYADVDLWNALEEVQLKESIEELPEGLETPLAESGSNFSVGQRQLICLARAILSHNKILVIDEATANVDHNTDSLIQETIRNKFKDCTVLTIAHRLNTIMDSDRVMVLDEGRLVEFDEPHLLLQNPKGVFTQLVEQTGKRSIDVLCESARQAYELRHDEPTNTPDDETVGTLSTNMADMEVENPDKKSNDNNGDGDDDDDDDGNDSDTPFIEYKGTASETSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB78</accession>
    <name>A0A6P8IB78_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Programmed cell death 6-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116298363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562642.1">
        <property type="nucleotide sequence ID" value="XM_031706782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IB78"/>
    <dbReference type="FunCoup" id="A0A6P8IB78">
        <property type="interactions" value="2398"/>
    </dbReference>
    <dbReference type="GeneID" id="116298363"/>
    <dbReference type="KEGG" id="aten:116298363"/>
    <dbReference type="InParanoid" id="A0A6P8IB78"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09240">
        <property type="entry name" value="BRO1_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09235">
        <property type="entry name" value="V_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000001">
        <property type="entry name" value="programmed cell death 6-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="3"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562642.1"/>
        </source>
    </evidence>
    <sequence length="831" mass="91867" checksum="D5D566008582AD11" modified="2020-12-02" version="1">MAGWIVIPSKRTEAVDFKKPLEKFIKNTFSEEVLSENSDAIAELNKLRNTAVMQVADKHESALQPLLRYYDQLVAMDGKLPISESQIRVSFTWYDAFDKGSLFGSKKASISSSAFERLCLLYNIGSLQSQIASSQNLHSEDGIKLAAKLFQNASGCFQMLKDLVFPQLHQVPTPDMSIEMLNALSSVMLAQGQEAIWHKTEKDNMKSAIIAKVAAQASDLYREANQACQVSSVRQQLEKEWIAVLGAKQNYFLAIANYHQGLVAKDKGAYGENVARMKLAKDLSESAQKESLGLFETKAWVDRIKRAHAEADKDNNLIYHDMIPSNDKMAVIGRAALAKQLLLSKPASDNFMDMFPKLVPMAVHNALVAYESRKAEIINVEVGRLREGTQLINSVLASLNLPAAIEDLSGDKVPKSVLEKAATIRERGGVATIDTLMQELPELLQRNREILDEGIRQLDEEERNDTQMRDRFKEKWTPKPSAELTVQLREETNKYKGILENAVCADGIVREKYNTHRKAMDILCKGEAEIAAFLPKISGGSSNAAGSSTVVELRKLMNEIENIKAERDSLEEELKAQQDDMAVKFLSALAADGSVSDVESIIGGNIASTYDPLKERASESMSRQERVLAAVQTTNEKFVQEKQSGQAVSEREAKLKDLATAYDSYMELTANLKEGTKFYNDLTPILVRFQQRLGDLVFARKTEREELSKGLQNAIANQPAEPTPEAPVHHQGTRQAPPRPPPPSTQAPATTQGQYASAPTAPSYPTQQYYQPMPTPGYAPYGYGSYAPPGGVGGYGMQQGQPPVPQGYFYGPPPGGYPYQQQPGQGQYGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID21</accession>
    <name>A0A6P8ID21_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">26S proteasome regulatory subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116299347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563852.1">
        <property type="nucleotide sequence ID" value="XM_031707992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID21"/>
    <dbReference type="FunCoup" id="A0A6P8ID21">
        <property type="interactions" value="2074"/>
    </dbReference>
    <dbReference type="GeneID" id="116299347"/>
    <dbReference type="KEGG" id="aten:116299347"/>
    <dbReference type="InParanoid" id="A0A6P8ID21"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031563852.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49195" checksum="A71B705EA47814CF" modified="2020-12-02" version="1">MGQNQSGGGGAGGDKKGDKDKKKKYEPPVPTRVGKRQKKAKGPDAANKLPKVTPHRNCRLKMLKMERIKDFLLMEEEFIQNQERLKPQEEKHEEERSKVDDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCTVLLNHKVHAVVGVLSDDADPMVTVMKLEKAPQESYADIGGLDNQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVREMFRVAEEHAPSIVFIDEIDAIGTKRYESNSGGEREIQRTMLELLNQLDGFDSKGDVKVVMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFHIHTGRMTLADDVNIDEYIMSKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYRKNEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID88</accession>
    <name>A0A6P8ID88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein Di-Ras2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563305.1">
        <property type="nucleotide sequence ID" value="XM_031707445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298870"/>
    <dbReference type="KEGG" id="aten:116298870"/>
    <dbReference type="InParanoid" id="A0A6P8ID88"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563305.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26873" checksum="9C7FAC2DF24C11A0" modified="2020-12-02" version="1">MVHNHSYPSLPSYXFKIGVLGAEKVGKTSLVRAFFGQKFVEKHVPTIDDYYVHAISVEGDYFSTCIIDTAGSYCFPVMQRLAMETSHGFLVLYSLDSEKSFVEALRLLDEIFSIKTRIDXSCRQIVVNLVATKLDVDCREREISYTRALDAMKVRPWIIGEHIEISSRAGFRVTLAFHSLMKNIVTEGQIKEKKKGRMRXARKLRSYKLVMKEKRKGKRKLGRMRHCFLSCGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDP8</accession>
    <name>A0A6P8IDP8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563670.1">
        <property type="nucleotide sequence ID" value="XM_031707810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299180"/>
    <dbReference type="KEGG" id="aten:116299180"/>
    <dbReference type="InParanoid" id="A0A6P8IDP8"/>
    <dbReference type="OrthoDB" id="5983036at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48462">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48462:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="227"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563670.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61603" checksum="A956481E34F72DA9" modified="2020-12-02" version="1">MHINDWNNGSDKQHIALKAGFVLLAVGLQKPSQKSKAKEHKECLMKRLALWKEEEIDKLVREGQMIQRRLIKFQKADTPNKAKIFAKLIMEGQINSALRYLSEDDCKGVLPLTDDVMMQLQEKHPKPQEAKLGSLLFGPIEDVPDSIYQQINGEMIREAALRTKGSGGPSGVDALGFKRILACKSFKKSSTNLCDALATLTRRLCTECSDPHTIEPLLASRLIPLDKGGGAVRPIGVGEVIRRIIGKCVMKVLKQDVIDASGSLQVCAGHKCGSEAAIHAMHNIFEADDTDAILLIDASNAFNALNRAAALHNIRVLCPTIATYAINTYREPARLFITGGRELKSAEGTTQGDPLAMGLYAISLQPLIMHLNISSSAQQCWFADDASGAGSLEELKKWWDALNEAGPDLGYYPNAKKCWLIIKPEKEETARXVFDGTSINVTTQGHQHLGAVLGSRTYLEEYVNGKVEXWISQITRLAEFAKSQPQACYVGFTFGLRHRWTYYLRTLPDIEDLLEPLERAVADVLIPSITEHNCTPIERDILALPVRMGGLGFTNPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF25</accession>
    <name>A0A6P8IF25_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Adhesion G-protein coupled receptor G6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116300429</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565165.1">
        <property type="nucleotide sequence ID" value="XM_031709305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IF25"/>
    <dbReference type="GeneID" id="116300429"/>
    <dbReference type="KEGG" id="aten:116300429"/>
    <dbReference type="InParanoid" id="A0A6P8IF25"/>
    <dbReference type="OrthoDB" id="8191206at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000054">
        <property type="entry name" value="Adhesion G protein-coupled receptor E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="778"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="863"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="15">
        <location>
            <begin position="547"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="16">
        <location>
            <begin position="719"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="991"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031565165.1"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111851" checksum="23AD281FAF8E4D62" modified="2020-12-02" version="1">MYEVFCMVVFLSAVNQVQSGNKDLLLGSGDILRINTTVPEAKLIKVQQGVLSKQITPLDVTLKDGMATQWPYKYAELVFSGNVVFEQGSVVNVSGKYGLSIQSLTGDITIRSNISMTCAVNASAMDMCLGGYSRRIIECVAQFVAVIVAGAGPGYVSDESCDVNAHYLSSQGAVGHGGKGAGAQKAGSDFYGWFYERENIKTMIGGSSGWHFKDSYKMPRSGGGAVEIQADNGTISLSSKISANAQHVSSTSETHSGSSGGTIRLKARKVILQPNSRLEVDGSPGGLASAINTVSDRFLRAGGAGGVVQIVAASGNIEQPEAISMKPGSSIGTNLRSDPGFLLIRDYSGKFYKTWNSSSSFPNVAYSWGEATSHAVKYCLPNSLGTHRTLALDQDPINKQIRQIQLRSSCLKNQSGLINPLELANYFAGLVTDIYYVVINQSLTRIQLDGCVEALTELKDTYMILANTSQVISLGDNWDFWDLFNNVSRIVDEIIDPRNKQIWNDSKLITMLDLMDEISEIAAGKILQSSPGIVARLGYLGTNMAIQIVKYAQADFQGFYSTISTRQVTDTTIQDSVILRRETIATHVTNTDKVSVVIKVYKDVEGLFPRDVDSSISEDHITQNMSHLVAITILINNKNIRILSAPILINFALQNTALRESTPHCVYWNKSSNAWKKDGVEFISSNNTHIQCSTIHLTTFAVLFSTTNVKFPDHHAFALDLLTYICCGLSIAALSITLIIFYSIEALSSDRHRIHMHLSLSILLSQLLFLIGIDATTHKVLCGIVAGILHYLFLASFSWMCVEGFHLYMKIVRVYGTESMRMMYYYIFGWGFPLIYVGGAASINSFGYGTNLACWLSLKNSFIWVFIGPVVIVALINLIILVMVIKVVVTSADMQKSQRARIMSGVKGVSVLLPLLGVTWVFGLLIVQDNSIVFKYIFTVTNSLQGFFIFSFHCVGNSEVRAALKRFRARTFDFNSAVFLPSNGDAVSSITRKSQKYRTSKEKVEKTRVHPLKNTSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFN8</accession>
    <name>A0A6P8IFN8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MORN repeat-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565502.1">
        <property type="nucleotide sequence ID" value="XM_031709642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFN8"/>
    <dbReference type="GeneID" id="116300725"/>
    <dbReference type="KEGG" id="aten:116300725"/>
    <dbReference type="InParanoid" id="A0A6P8IFN8"/>
    <dbReference type="OrthoDB" id="437960at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052849">
        <property type="entry name" value="MORN_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46917:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565502.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16389" checksum="BC002B2ECE5D8191" modified="2020-12-02" version="1">MPAASSKKQDKSKSEHGSAHVLKGVYMFPNGDKYDGEYIQANGGLQRSGYGENLTAGGLCYQGYWSDDKMNGQGKLIHPSGAVYEGEFVENRFHGYGKYTWPDGSIYQGNFSENKLEGHGTFTDINKQVWHGNFTHKAAPGLKFKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG50</accession>
    <name>A0A6P8IG50_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein max</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myc-associated factor X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116300838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565658.1">
        <property type="nucleotide sequence ID" value="XM_031709798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG50"/>
    <dbReference type="FunCoup" id="A0A6P8IG50">
        <property type="interactions" value="3384"/>
    </dbReference>
    <dbReference type="GeneID" id="116300838"/>
    <dbReference type="KEGG" id="aten:116300838"/>
    <dbReference type="InParanoid" id="A0A6P8IG50"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11406">
        <property type="entry name" value="bHLHzip_Max"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000023">
        <property type="entry name" value="MAX isoform 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031565658.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23911" checksum="830AD8FAAB915A76" modified="2020-12-02" version="1">MDTCASHEGEATRRREKIQSNMSEDEKEVDLESSDDVSDLADKRAHHNALERKRRDHIKDSFSHLRDSIPSLQGEKEMTRGMKCENITPKASRAQILNKATDYIQHMRKKNHTHQMDIDDLKRQNMILDQQVRALEKARTTGQFNADATAALLSTPDSLLSTSPNPESLLEGLKDPNSPLDGLTVKTENNNTDSASDEEYPSKTKRRKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGX7</accession>
    <name>A0A6P8IGX7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116301201 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116301201 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116301201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566082.1">
        <property type="nucleotide sequence ID" value="XM_031710222.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566083.1">
        <property type="nucleotide sequence ID" value="XM_031710223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGX7"/>
    <dbReference type="GeneID" id="116301201"/>
    <dbReference type="KEGG" id="aten:116301201"/>
    <dbReference type="OrthoDB" id="5988116at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566083.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="54082" checksum="3339F025B1AF8642" modified="2020-12-02" version="1">MKPIITVHRGELLQIKRMIENGDLRGDMYGLRTESRQPVIQFVCGENNKSNNTTERESTCQDMLKNRHGLLKLGEWVVSKRNVSRKDVVLFFNKEGELIFAEDRGQECTIDILKGQSAFRLYEPLTKVLPDLSVPIPTEEYDKENENKEAEVTKEQWYSEPDGVKLLQGIYATFPQKGLTILNMSRDKATEDISLSLTVDSMPIAVYFPASFPYENPKARVDDENDWSEVDLQYEEGMPPEEAVPLLCALLLNLVSDEENKRQLRKQERKNNKQNQKLKAEKIPKRGGLHSEQNQTPSMSDAQRNQDEPSTGQKQPQLKGDHEQRNEDEPSTGQKQPQLTGEHEQRNQDEPSTGQKQPQLKGEHEQRNQDEPSTEQKQPQLTGEHEQRSEDEPSEQEHPSPTFEHDQQHQNQPFPGQEQVTTPRNKTDEVTEQTPDENMDIDLNLEKQQKIDEDMEIDDEDQQNISTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIJ4</accession>
    <name>A0A6P8IIJ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116301671</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116301671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566622.1">
        <property type="nucleotide sequence ID" value="XM_031710762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIJ4"/>
    <dbReference type="GeneID" id="116301671"/>
    <dbReference type="KEGG" id="aten:116301671"/>
    <dbReference type="InParanoid" id="A0A6P8IIJ4"/>
    <dbReference type="OrthoDB" id="5981450at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028385261" evidence="4">
        <location>
            <begin position="22"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031566622.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="54856" checksum="41F8621E5DE072BC" modified="2020-12-02" version="1">MRWYVLLALVVIFTLLVIEESESWGRRRWKRVRVRRAVRHVRTRRIRRFVPVRTRRLRRIVRVRTRRLRRLVPVRTRRLRRVVRVRTRRLRRLVRRVRTRRLRRLVRRVRTRRLRRSIRRKIRRIRFRTKKLIRIRTRRVLKKFKIKKLTRKVKKLLKKVKKLPPFKKPGGKWWSKLQDWIKGKIIASKEMLQKWGSKLKGLISKEKEPPEEGTSGPGVQPTDGSGVQPTDGPPPTKDPFLEVKQGNFTFEAEGDDNSSSPYFSRKLHVFSNTSGVTVGRGYDVKEKMILQIKRDLTLVGIQNSIAMRLMNAIHLEGDSAKIWIKNNKLESFMITTQQQKKLFELEYPRKLNKAKTTVEKYSKTGLKFDHLKQVVKDLIVDIFYRGDYSMSDSDQDKKECSQIMQEVFDQSQTSLKPMTVLMLDEEFWLNFVRVDIGRYYIRSNYIADACEKDANCDVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIZ0</accession>
    <name>A0A6P8IIZ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116301757</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566734.1">
        <property type="nucleotide sequence ID" value="XM_031710874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIZ0"/>
    <dbReference type="GeneID" id="116301757"/>
    <dbReference type="KEGG" id="aten:116301757"/>
    <dbReference type="InParanoid" id="A0A6P8IIZ0"/>
    <dbReference type="OrthoDB" id="5977530at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566734.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42098" checksum="D4BAD2A0134895B2" modified="2020-12-02" version="1">MMKNNDDDETQSNTTAKVEKVESPQATNVQCVEQQTPYKSPVASRTRSFSALRRSYMRKKQNKEADKSNDMDMSSTSTSTESNVVENAGENFLQEREKEVEIPYQVKEIDSSTCNEGNSMKEGPDDHHVNSNNEDKNDQYYKNKFHEMVQNLKQMQEQFSQAHQNTHKNITAYDAFIKELRTSLEQEKRKNATIEEELREIKERLLMTSNEIELAKTNEQQHNNRSISTACIPQEPSQSEESSQLSEVEDLEKTETSTLLAMIKFYAGLTGITLSADIPPSNSELIESFCCAYRPKGPTGHVMAFRLTHDKEFQEYEYSPSFQTPKRGEFLHKIPGHLKETMYFNSDQAQSFLSSLIKACTESGSQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK20</accession>
    <name>A0A6P8IK20_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 154-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567102.1">
        <property type="nucleotide sequence ID" value="XM_031711242.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IK20">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="GeneID" id="116302049"/>
    <dbReference type="KEGG" id="aten:116302049"/>
    <dbReference type="InParanoid" id="A0A6P8IK20"/>
    <dbReference type="OrthoDB" id="9445857at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029512">
        <property type="entry name" value="CCDC154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35153:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15450">
        <property type="entry name" value="CCDC154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="680"/>
        </location>
    </feature>
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        <location>
            <begin position="808"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567102.1"/>
        </source>
    </evidence>
    <sequence length="876" mass="101483" checksum="4484E194EB3E2C12" modified="2020-12-02" version="1">MQNPVQKDAAFAERLRRLEFNKTSPMAQPPWAKEPDISASSRRRPMNNPTNLPALPGTTDRRNSPPVSTEGNRLRKLEGRISLSEQSNRALLEEIVRLQGELKNSVRRNEETLRDEKEHRQVLSEKIRAANNLYTQLMMRLARTEEKLDSEHSAVGSLVNHTKHVEQTLMGNQQQLLNRREQVHVRIERIKEDLEDLQDTYEQSQKNMRAMSEDVRNTKSKLEVQTVQFGTMVQELRQRMKKIENDSQSAMDYLRKETDSRGVMEVSTAQLKNTIELRLSEIKETVGELRRRLELEESERRSASQQALLSIEQLKTMIQEVDHKREEDTQNTSMLSRDKESMMMSERSQIANRMAELTEEQNKKLIQKEIRLREEAQSKFLAMEKKFREEQGSRLNFEKALREEIERRWQSLKSYLDEEVQTVKGGGKMSQVKTDQSLVRLNEAISLLERQMEEGRKAVEQVLHAEITSRQSQHEKLASKLTQMQEKLDLAISTLQQAVGGINTRLDEDVKKAKEELKSLIDQSSNTGVKGMADMDSRIGKINKKVIDLEDAIERIDKRIKEPPIIQVTSTGEDNSSKAEENIARWKRETEERFYEVDKKIKPLPDEMNQMQSELKALREGFKALAEEMLRVPTPRQVTPETRVPTPPPPRTATPRTQTPRTPKTKTPVPKSPEPSESDIVEMKERMQKLEDTVSEQNSQVSKLESTVETLRMVLSQKILSEAQTRNKHIKGVESDIEKIVKYYLLDHRRIFVKYKDINPIRALPGEGTGVMRFALLEINRWGIYQAHKMMQIKNAWYTLLERSRKREDEMPEDPDLPPPIVRPDTADSDDVKDDSDDDDDDDDDDDDDDXDDDDDDDEPPNKNKNEPAKNNKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM99</accession>
    <name>A0A6P8IM99_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116302534 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567715.1">
        <property type="nucleotide sequence ID" value="XM_031711855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM99"/>
    <dbReference type="GeneID" id="116302534"/>
    <dbReference type="KEGG" id="aten:116302534"/>
    <dbReference type="InParanoid" id="A0A6P8IM99"/>
    <dbReference type="OrthoDB" id="10327397at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021184">
        <property type="entry name" value="TNF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00251">
        <property type="entry name" value="THD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567715.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42840" checksum="3B84F7D68BD48016" modified="2020-12-02" version="1">MGQNTEDKLETSQRNCCFCGTTTRKIYILIFLIAILNIAIWGSLVAAHLHQRNELRELRKSSTIAIAECRRHVASINPKLHQDRINNMSIQRNIIRKSSRNIERLKETKNVSPRQAKLKVPTSCPFQKRRRLCSLIAREVSRHVQLNLTELRKEVNELRMKINNVQQDRYREAYVILIGKNHQNRLTKMNVKDMYNIRWDRSILRKCRTRSSQMDATTLEQCRITRYSGVNFHYSDKRIISAVKVTVPGIYLLYCQLTFTINNTSYSNNIAHLISKVSILMTKGTSEHVELISQIPVVTRQGNDPLITVSVFTQAYLYSRSTIRVTISLKNGSKLPLDGNMVLELYQRNHGTFNVFGMHLLKKTDDRGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMA9</accession>
    <name>A0A6P8IMA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116302882</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568141.1">
        <property type="nucleotide sequence ID" value="XM_031712281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMA9"/>
    <dbReference type="FunCoup" id="A0A6P8IMA9">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="GeneID" id="116302882"/>
    <dbReference type="KEGG" id="aten:116302882"/>
    <dbReference type="InParanoid" id="A0A6P8IMA9"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="279"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031568141.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="42122" checksum="0FFFD7AA45E14079" modified="2020-12-02" version="1">MACSRSYKDTDIVIVSAVRTPVGSLNGDLSSLQGHELGTLVIKEVLSRSGVSPCDVSEVILGQVYTAGQGQGPARQAAMNAGIPPTVPAYGVNMLCGSGLKAVALGYQAIATGDSSVVVAGGQESMSQAPHCCHMRSPVKFGDVTLVDTMLKDGLIDAFHKYHMGITAENVAKQWGISRHEQDKFSFTSQQRTEAAQKAGYFKDEIISVQVKSRKATTEVTEDQFPRHGTTLDGLSQLKSCFLQDGTGTVTAGNASGINDGAAVVMLMSFAEACRRSVKPIARIISWAQAGVEPSVMGTGPIPATRKALSKAGWQVKDVDLFELNEAFASQSCAVVKELNLDPSKVNISGGAIALGHPIGASGSRILVTLLHNLKRTSQQKGVAALCIGGGMGIAMCVETLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP58</accession>
    <name>A0A6P8IP58_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorting nexin-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568669.1">
        <property type="nucleotide sequence ID" value="XM_031712809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP58"/>
    <dbReference type="GeneID" id="116303291"/>
    <dbReference type="KEGG" id="aten:116303291"/>
    <dbReference type="InParanoid" id="A0A6P8IP58"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF2">
        <property type="entry name" value="SORTING NEXIN-5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568669.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41791" checksum="A2C02228A4719F59" modified="2020-12-02" version="1">MAENGDIEEWSVKVLDASKDGDVVKFTIQTKTSDHDNEKGVIVLREYDDFEWLYHCLTTQNKVDAVVIPPLPARPIVTASAAEAKSKKQLGKDSKTMVPDEFTRDCRNLEKFLQLILVHPAFKKDEGLEKFLTEEEAPVRSKVKKGLFDSLSKTVGEVRFQGYKDRDEDFQKHRDFVDKYLLASKEASMNFTKMINSQQRVALGLGELGTSLSTAATLSDIASQKLKPSLSIFSNALTSHKDSYEVMSTNDDNTLGFSLELYTRYMESAKEMLFRRTCKMVEYENAVKALEKAKPQKKDQCETVKNDTEEAYNDITEMGASEMSRFNRQRVLSLQSSLTQYAESRIKNGRDTYAVLAKLLNDVKKASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPZ9</accession>
    <name>A0A6P8IPZ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">ETS translocation variant 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116303696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569141.1">
        <property type="nucleotide sequence ID" value="XM_031713281.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569142.1">
        <property type="nucleotide sequence ID" value="XM_031713282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPZ9"/>
    <dbReference type="GeneID" id="116303696"/>
    <dbReference type="KEGG" id="aten:116303696"/>
    <dbReference type="OrthoDB" id="8196042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF133">
        <property type="entry name" value="ETS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="4">
        <location>
            <begin position="269"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031569142.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40280" checksum="B5F81DA44EB75BBF" modified="2020-12-02" version="1">MVRAASGSQSPVDMAFNDIFEVIQAIEEMPNTAQIVPSRDDCSTELFEMQNENFRGQAKIYGSDLNLADTKPEATASSNYQPLNHISGLVGLSLQLDRTRAKPEPEPFLRDFPTAFPDDVLWGEKLINDTKNLIQYPPFFSRDLSENYRNFPVPEGQEMHIVPELGEKWLDTPEVLFADNEEIIPKTPEDSNFSEYSSDSEPPFEVKKVDEAERMSESPDSFSSRLEAHSPWFEIDSTNSHSPLVITKRPTEVKKEIKKCKSSFKSGRPRLCQFLLELLSHPEKYSHLIEWIDKERGVFKFLNSSRVAQEWGERRNKPRMKYENFARSLRTYIAKGILTKPRSKLVYKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ27</accession>
    <name>A0A6P8IQ27_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Spondin-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569176.1">
        <property type="nucleotide sequence ID" value="XM_031713316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQ27"/>
    <dbReference type="FunCoup" id="A0A6P8IQ27">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="116303725"/>
    <dbReference type="KEGG" id="aten:116303725"/>
    <dbReference type="InParanoid" id="A0A6P8IQ27"/>
    <dbReference type="OrthoDB" id="6090599at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000120">
        <property type="entry name" value="Thrombospondin, type I, domain-containing 7Ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF15">
        <property type="entry name" value="SPONDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028041600" evidence="9">
        <location>
            <begin position="20"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="10">
        <location>
            <begin position="52"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569176.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52006" checksum="5E8D3CDD7F0AE849" modified="2020-12-02" version="1">MFLARASFIISLNIILAVAESTIENQTCSGEDCKLNSRTEVGRTPPQPVKANDLKCCACGQATYRMTFVGKWSRLTHPRHFPGPMSSWSALIGCSHSNEYHMWRYGNLASLGVQRLGEWGSTSKLEEEMRKQGNKVLNIIKMPGLWWGVGRSVIEFRADQTHSLLSVMSRIVPSPDWYVGVDSLNLCHVNCTWKNEETVDLFPLDAGTDDGINFISVNARSNPQQPIRRIDTRLHNHPMSSFYLPDNDAIRPFAQIKIERLGVSGSCLRSNMKGPFPPKPARIDCQVSRWSSWTPCSVTCGLGKQVRGRDVIVQPMHDGIPCPNLYDYKICDLQTCDDNNNNKCLVSAWSTWSKCTGTCGIGFKVRKRTIIRQPALGNKTCPKLIKKRRCRLSPCQKDRGRASAADCVVSAWSSWSECNRQCNRGKKKRTRQILNKAKDGGRRCPRLQEKRKCLVRKCPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQB5</accession>
    <name>A0A6P8IQB5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spliceosome-associated protein CWC27 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116303667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569109.1">
        <property type="nucleotide sequence ID" value="XM_031713249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQB5"/>
    <dbReference type="FunCoup" id="A0A6P8IQB5">
        <property type="interactions" value="1387"/>
    </dbReference>
    <dbReference type="GeneID" id="116303667"/>
    <dbReference type="KEGG" id="aten:116303667"/>
    <dbReference type="InParanoid" id="A0A6P8IQB5"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22288">
        <property type="entry name" value="CWC27_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000007">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CWC27 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031569109.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51727" checksum="E828DE980683E8D1" modified="2020-12-02" version="1">MSNIYIQEPPTNGKVLLETSVGDIDIELWSKEAPMACRNFIQLCLEHYYDDTIFHRIVKGFCIQGGDPTGTGFGGESVYGKRFKDEFHQRLKFNRRGLVAMANSGPNDNGSQFFFTLDRTDDLNGKHTIFGKITGNTIYNMLKMVDLEVDDNDHPLYPPKIKRTEVLSNPFDDIEPRNNKMKKDEALAPKKPKAKGTKNFSLLSFGEEAEEDEEEVINVGKELKMKSSHDVLDDPTLSKQTVNQDASKEKDGDKNLGEQARQKLKKQTQEYDDDSSEDEPTESTSKSKELRKESTKLLKEIKESRRKAANKETEPESKTVASKDKLSRVVADFRAERDEYVAKVKGTIKAKGDGRSEQTFSLLADFQAKLNEKIDEENSDEENSDKDEGDEKSDDIGWMTHVLHCEEGMKQKVKDANIQDEDTYEIFDPRNPINKRRREASKEAMKGKRRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQT1</accession>
    <name>A0A6P8IQT1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116303257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116303257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568628.1">
        <property type="nucleotide sequence ID" value="XM_031712768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQT1"/>
    <dbReference type="GeneID" id="116303257"/>
    <dbReference type="KEGG" id="aten:116303257"/>
    <dbReference type="InParanoid" id="A0A6P8IQT1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031568628.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34144" checksum="93DBEE8CDD7B2ED6" modified="2020-12-02" version="1">MLKWKLSRSFCRAIMSKLLIEGEGLTATVTLNDGHKMPLFGLGVYQAKPEETSNATTTAIQHGYRMIDTAALYGNEKEVGEGIKKSGVNREDIFVTSKVYPNKENHGYNESIRAVKESLAKLDTGYIDLYLIHSPSPGKNIETYDGLLKMKEEGLIRSVGVSNFGIHHLEALKKSGRPTPAVNQIELNCFCRREDTVKYCRDHGIVLEGFCPIFRGRKNNDPCLVEIAKRYNKTVPQLLNRWSVQKQFVTIPKSVKPDRIMENAQIFDFVISDKDMQVLDNLPTERCSFLNMKEPAEAPWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS90</accession>
    <name>A0A6P8IS90_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit RPN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116304446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570041.1">
        <property type="nucleotide sequence ID" value="XM_031714181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS90"/>
    <dbReference type="FunCoup" id="A0A6P8IS90">
        <property type="interactions" value="2483"/>
    </dbReference>
    <dbReference type="GeneID" id="116304446"/>
    <dbReference type="KEGG" id="aten:116304446"/>
    <dbReference type="InParanoid" id="A0A6P8IS90"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="252"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00075103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570041.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="57510" checksum="D4BDBED0365991FA" modified="2020-12-02" version="1">MTKDVEMKESSTAKNKDESKEEPKEEVSKDEQEKLILEDIKEHVKCIEKAVATKEPRFTLRTLRGIPGTRRKLSHPLLRKLICGYMPLASPNKDALLAYLDEPMDTEDSGAPFRPRSAKAASIPLLPEIETYFHLLIVIHLIDSKCHQKAVKCSDDLMKKTQGLNRRSLDPLLAHCYFFHSRAYELTDNLKDVRSFFHGKQRTATLRHDDEGQASLLNLLLRNYLHYNLYDQADKLVSKSTFPSLASTNAWARYLYYTGIIKAIQLDYSEAHKNLLQAIRKAPQNSAYGFKQTAHKFAIVVELLLGEIPDRSIFRQPFLRKTLVPYFQLTNAVLTGDLKHFNQVVEKFKDKFLAEKTYTLIIRLRHNVIKAGVRMINLSYSRISLVDIAHKLQLDSPEDAEFIVAKAIRDGVIEATINHENGTLQSKELIDIYSSNEPQSAFHQRISFCLEIYNQSVKAMRFPPKSYNKNLESFEEQREREKQDMELAKEMAEDDDDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISB8</accession>
    <name>A0A6P8ISB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inhibitor of Bruton tyrosine kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116304473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031570071.1">
        <property type="nucleotide sequence ID" value="XM_031714211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISB8"/>
    <dbReference type="FunCoup" id="A0A6P8ISB8">
        <property type="interactions" value="1574"/>
    </dbReference>
    <dbReference type="GeneID" id="116304473"/>
    <dbReference type="KEGG" id="aten:116304473"/>
    <dbReference type="InParanoid" id="A0A6P8ISB8"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18500">
        <property type="entry name" value="BACK_IBtk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="337"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031570071.1"/>
        </source>
    </evidence>
    <sequence length="955" mass="107712" checksum="A7537EFA93193D80" modified="2020-12-02" version="1">MRRCKWLLRKELLVADVAVGKQLYIITDRGEMFTCTNAGGGHPVVRPARSSPSPSPYRPFGGWDQKEVINYNVTRCPMVHRGIKVFTDGKSKGFAVLQVDPSTGLVKRPTIRNSTMVDDFVHFLDETMVEDDIHDVNLVVKGRVFPAHAFILASRSPTFRKLLLEEHKKMSHSENVAIMTVKLDNVEDCSVVTKYLQDLYSGLQVNDAILFGSKINNKPTKKTPKAKEVKVSNGLDEGTEDLSLLNLLVQNYEEFTMVDLDDFSALSFLDKEKENDVVEDVSDPMESAKKKPKSTAKTDMKTQPNTKHKRKKGKKHIDEENVFKGLKFKRTNCPEFHDVAIESEDHVNFHCHKCVLVAQLDYFRSMLACGWLETSKEMKVLNMPIHSSVLEIVLDYLYTDDTKTIQGQQDIEFVGNILVIADQLLIGRLTEICESVMTKLISHKNAIELLEFSCVYNASQLKASCLEFICCNLSSLLESGFLNLLSEDTLNELSTAYRDMISSMAWRMITPSHDHLSFLSPELSSSSSPRKRRTSSRKRSVKSESEEETEKDTNVSEEKVQENGNREQKLSETNHESVFEVEENEENFREKESKTILMDLITTNTENKLDSEKLNDEGNWYRKEEGKSEQPKTSKYNKNRSLKQEENIIKSSPNTSKPQEIPKPPKQDLPPTRPAWGVNFTSPSSPPSSDLKTIMEQEQLTVRKQGSHSETNKSKTNRSIRIEPKSKQSQKQKKKALKNQQLDVTVSPEPENETTTGEAKTEEAKSKVICNPWGLQEKKPTPVRSLRELIEQEEKSAQSILPKTTANLSPKTLNTTRKTNEKGKVEKTSGAKRKISWGLPQVEQKAMPEQEASGKEPAVSPRSAWSSSPSPGSPPSASVSFADILHLQERENTNLNRAKEKPLSLIQLEDRAIQELLEYYGGRDCACEIITVERVPAATATPVWNRARTASATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITF2</accession>
    <name>A0A6P8ITF2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protein HEG homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116304599</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570222.1">
        <property type="nucleotide sequence ID" value="XM_031714362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITF2"/>
    <dbReference type="GeneID" id="116304599"/>
    <dbReference type="KEGG" id="aten:116304599"/>
    <dbReference type="InParanoid" id="A0A6P8ITF2"/>
    <dbReference type="OrthoDB" id="5953547at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000653">
        <property type="entry name" value="Putative Fibrillin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="15">
        <location>
            <begin position="90"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031570222.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30269" checksum="BD658BE5C921B74B" modified="2020-12-02" version="1">MSQNPCEGKPCLNKGKCLLHKNRRDYRCRCKKGYSGEKCQLDVNECETKPCDANAACINTKGSYQCTCNSGYHGNGKQCSPYARGLDSSAILSNYGNATFLQDLGLYLFPVVQNPSKSLWVRCWHAANDGWNVRTTFHPQCDGNSPTVTIVRVVSYVFGGYSDVPWQSSGGYTSSSKSFLYSLRNIYGYSPVNLTLNGQNDGKAIYNGAGYGPVFGGGNDLFISDFASSYNDSLTSLGNTYRTHQICSSRGTCTSFMAGNDNFSPNDIEVFYETIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITG4</accession>
    <name>A0A6P8ITG4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116304859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570506.1">
        <property type="nucleotide sequence ID" value="XM_031714646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITG4"/>
    <dbReference type="FunCoup" id="A0A6P8ITG4">
        <property type="interactions" value="1933"/>
    </dbReference>
    <dbReference type="GeneID" id="116304859"/>
    <dbReference type="KEGG" id="aten:116304859"/>
    <dbReference type="InParanoid" id="A0A6P8ITG4"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031570506.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45085" checksum="341C1CCF32618094" modified="2020-12-02" version="1">MSDPFKENKTGFSSFTARSKTKLPLLRTPWSSKRYTPYTRTPKTGRVSRIPTKNPPSSEQGVLRDTTNLTPVNKAKVLGKPTPNATIKKEKELTEINEDILSVVGKTWRINQCSPLYNFDYEKSSLQKYQKLLSAHLESDAAKGIAFEVDEDLKNSTFRAEFDVLKDFSFYDTDYTGLRIKVFSRKKQNTVKNANGMELRIPVLDAIFCYFGNEFEDKREVECFTSLPVCLVKGPMALAKCVFNWFEAQFDCRMIPMQFSPMDLSWYASLWAGIVPKGSKSELELCYSVPSSVKGLNRVIYSINALDAQKLWNCHHTNNSAIFTDEESSCFMKALESHFYRHFRVNLGALTLTRIGNPLVFIGCEGRIKISQAMYVRHILQQITASISEKEALGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUG3</accession>
    <name>A0A6P8IUG3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 27-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116305207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570926.1">
        <property type="nucleotide sequence ID" value="XM_031715066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUG3"/>
    <dbReference type="FunCoup" id="A0A6P8IUG3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="116305207"/>
    <dbReference type="KEGG" id="aten:116305207"/>
    <dbReference type="InParanoid" id="A0A6P8IUG3"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031570926.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18775" checksum="DDBF86DDC15DE295" modified="2020-12-02" version="1">MSAIRARTSSLIFQESPTKDKKAKTAKGGNMTPIDLILLSRDFFLMNGEPEEKLRLRKMFQGCNVDQITATGVTALTQSALDGRLENIKLLIELGADVNKKDRFGWTPLHYAVSEGYDQICRYLLNHGANARIENAEGEFPVELADQENIASLMLDATINMRRLSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV03</accession>
    <name>A0A6P8IV03_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reversion-inducing cysteine-rich protein with Kazal motifs-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570772.1">
        <property type="nucleotide sequence ID" value="XM_031714912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IV03"/>
    <dbReference type="FunCoup" id="A0A6P8IV03">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="GeneID" id="116305078"/>
    <dbReference type="KEGG" id="aten:116305078"/>
    <dbReference type="InParanoid" id="A0A6P8IV03"/>
    <dbReference type="OrthoDB" id="5956770at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056978">
        <property type="entry name" value="CC4_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056976">
        <property type="entry name" value="EGF1_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056977">
        <property type="entry name" value="FnI_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056979">
        <property type="entry name" value="FZ_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039016">
        <property type="entry name" value="RECK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487:SF3">
        <property type="entry name" value="REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23332">
        <property type="entry name" value="CC4_RECK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25027">
        <property type="entry name" value="EGF1_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25028">
        <property type="entry name" value="FnI_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23298">
        <property type="entry name" value="FZ_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027844085" evidence="1">
        <location>
            <begin position="17"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="628"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="742"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570772.1"/>
        </source>
    </evidence>
    <sequence length="975" mass="107780" checksum="95965A96C4BD8B4B" modified="2020-12-02" version="1">MRVLFSTLLLVQAVLSNQSDILCCKQTSGFKQCKSACNKFVSQTEVNLRLRALKELPKFCPGHLTKLWRCLNETNPGTRQYLESKLPNKAGVCCLMTSTSKCRRDCLNGNKQALNTSCSDIHLISCVTRHDATANCCQGASKSCIKACKLLLASQPASKNNLLHRVKKNCKMGGRHVFECAKKHESTTKNPDGYKQLKCCSIVKDPVCRESCQKGHLIKNLQEAMDYLTKACGSPLGKKENNAMWNCFLKVEGPTEIPFSEETISPLTGTPKMDGAKRHCCPKAASTNCFWLCVKMFKSRWSASQTYPEFDMKCAYQPSEVNLMNCLADVTKPCQLGCTGLNFCTNFNNRHTELFRSCDAKADSYAKSHMQHWSKGIINVPGMPILVQDIKKCLPDTWKAIACLLQIKPCSIKSHRSTICKSDCIEILQKCGNSSSYSNLKKVEEVCNKLSPNESNCISINSYLKPSKYKDVTDEVTHPCNPNPCEKNKMCDINRTCYAASLDGCEPHNCVPGCPLGDASNFLVRMGEYARVPVDSGREGCFRVCHCGGQSRLTSCTILNCVPRRDCPIKSQKELTKKEHGERFMVGCNFCACFAGELMCTKRQCLEPPSQIPDVETEGRPKRNQTPMFTGLPCGCDSKHNPVCASNGQTFPNLCIARCAGFKDSQPGSCESFDPCKNNPCSKGQRCLIDRKTCLTPTDSCNQYFCVQESSYCKDMQLEPVCDNEGQQHPNLCSIHFKGKQLAYKGFCKPYCSQPTKPLCGINGETYSSVCAATSSRVIVDYEGHCRAIGHQVVSISEGRCKDVKCPPLVPANCVGIHPPGACCPHCAAQIRILVSLTQLSINSEGLQDHYKPITLEHLLVALRRHVTTTECDLFGYQSIEGDLVILIKAITNKPTVLQIEACSLEAQRIEALINTGSPSFTSHVILSTLKAADTQTPSLSLRQTQASSTNHLHIPHLIICLLQTIIILKWSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXP3</accession>
    <name>A0A6P8IXP3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin, cytoplasmic-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571867.1">
        <property type="nucleotide sequence ID" value="XM_031716007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXP3"/>
    <dbReference type="FunCoup" id="A0A6P8IXP3">
        <property type="interactions" value="2405"/>
    </dbReference>
    <dbReference type="GeneID" id="116305986"/>
    <dbReference type="KEGG" id="aten:116305986"/>
    <dbReference type="InParanoid" id="A0A6P8IXP3"/>
    <dbReference type="OrthoDB" id="6016663at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571867.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41847" checksum="99F074667FE97876" modified="2020-12-02" version="1">MAEEDVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQTAASSSSLEKSYELPDGQVITIGNERFRCPEAMFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYANTVLSGGSTMYPGIADRMQKEISALAPPTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPAIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYF8</accession>
    <name>A0A6P8IYF8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase A and acyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116306311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572204.1">
        <property type="nucleotide sequence ID" value="XM_031716344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYF8"/>
    <dbReference type="FunCoup" id="A0A6P8IYF8">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="GeneID" id="116306311"/>
    <dbReference type="KEGG" id="aten:116306311"/>
    <dbReference type="InParanoid" id="A0A6P8IYF8"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028162213" evidence="6">
        <location>
            <begin position="19"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="7">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031572204.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31813" checksum="74C21C9CE6B50116" modified="2020-12-02" version="1">MNGTSVLTLLALAWIATSCRCPGSPGDLIAFTRLKGFYHHYAINVGNGYIVHLSGSSTNELQKCFEASFLRSGRCEIAKVKKEKCADVVKPGSKHIENKPWKGKKPLPANEIVERALSKVGTSGYNLLYKNCEHFARWCRYGEEDSKQAENLMLGLYMLRVTFFASFLLLFLVSLPMLYVAFRWFLVHTSIPLVMALLSLAFYALLWAFCEAMVEALRLLTRGTHFKELERNKPALLHKVQLTVVAWLFPPGTIFGDTLIIHEKEEKNVLIEYDLLFTTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYP6</accession>
    <name>A0A6P8IYP6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116306390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Nup35 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572299.1">
        <property type="nucleotide sequence ID" value="XM_031716439.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IYP6">
        <property type="interactions" value="2276"/>
    </dbReference>
    <dbReference type="GeneID" id="116306390"/>
    <dbReference type="KEGG" id="aten:116306390"/>
    <dbReference type="InParanoid" id="A0A6P8IYP6"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000095">
        <property type="entry name" value="Putative Nucleoporin NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017389">
        <property type="entry name" value="Nucleoporin_NUP53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038119">
        <property type="entry name" value="Nucleoporin_NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9 10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="12">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031572299.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36003" checksum="684EB6C35E8A85B0" modified="2020-12-02" version="1">MDLNFGDSTTSPTASYLPGYLLGGNTQSSLPMSKNWSSPLGSSQRSPYYKNSKSPPRGVTSSFTSPHQLSVKEKQYNSIRGTPTISRTPKESIXAPPVESLYNTKYAVSSPFTERTLDRTQMDSINTYSPVSKSLQHTPNIGKEVTFGRTTIAVTPPSPAQVDPFYTQGEGLTSGDILNECWVTVFGFPPAASSFILQQFSQYGNIIQKEVMANRNWMHIQYQSKLQAKKALSKHGKVFSGNLMIAVIPCIEKSIMACIGKENVMAASNDAINDISMKSSTIPCKTPIRPLTAAYNAASSTHQVEPLDGKTPQKSDTIISKAMEYMFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZK4</accession>
    <name>A0A6P8IZK4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate and serine-rich protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572649.1">
        <property type="nucleotide sequence ID" value="XM_031716789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306703"/>
    <dbReference type="KEGG" id="aten:116306703"/>
    <dbReference type="InParanoid" id="A0A6P8IZK4"/>
    <dbReference type="OrthoDB" id="10517139at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572649.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16795" checksum="FC7E3D9DE26EBDBD" modified="2020-12-02" version="1">MYKSEKVQVINAWLSMQLLNTMTGTTEEEHEEDDTNEDTEDLDSDKKTDIVTHEIGIADSEENDVCIQFTSASNSXLLNTTTSTTKEDHEEDGTSREDTEDDDNSCEDTNEDTEDLDSNEKTDIVTHKIGITDSEENDVCIQFTSASNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0E9</accession>
    <name>A0A6P8J0E9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">40S ribosomal protein S10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116306921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572919.1">
        <property type="nucleotide sequence ID" value="XM_031717059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0E9"/>
    <dbReference type="FunCoup" id="A0A6P8J0E9">
        <property type="interactions" value="1736"/>
    </dbReference>
    <dbReference type="GeneID" id="116306921"/>
    <dbReference type="KEGG" id="aten:116306921"/>
    <dbReference type="InParanoid" id="A0A6P8J0E9"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031572919.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18441" checksum="5E34FFF3E32F8DA0" modified="2020-12-02" version="1">MLIPKKNRVAIYEYLFKEGVCVAKKDFNNPKHMCIENVPNLHVCKAMQSLKSRGYVSEQFAWKHFYWYLTNEGITYLRDYLHLPPEIVPATLRRQVSRAETARPRPKGMDGGPRQGGPDSSDRDAYRRGPPGGDPKGGPGTDFKPEFRGGFGRGRGGGGGGFGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J204</accession>
    <name>A0A6P8J204_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sortilin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571745.1">
        <property type="nucleotide sequence ID" value="XM_031715885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J204"/>
    <dbReference type="FunCoup" id="A0A6P8J204">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="GeneID" id="116305888"/>
    <dbReference type="KEGG" id="aten:116305888"/>
    <dbReference type="InParanoid" id="A0A6P8J204"/>
    <dbReference type="OrthoDB" id="5956263at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF23">
        <property type="entry name" value="SORTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028145789" evidence="9">
        <location>
            <begin position="22"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="10">
        <location>
            <begin position="124"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571745.1"/>
        </source>
    </evidence>
    <sequence length="830" mass="93895" checksum="AF70A27745975826" modified="2020-12-02" version="1">MASNIVKLCIFVLQLSIVVQGVKYPAKSRVKDIFEAPKSGYKELFSTHQHEENRLRRSQQEVLTNKHRIRRNTNPDWCSDPTKIKDHDIINRLWKFPVGDNHLSFSMTWVGKDFQTILLLATTEFFIFSVQRSALYKSTDFGETFNKTNQNIYEGNIRKNDGLQRSPVDPNMVILVSFSLPIIGVSSLYITLDGTKTWKKVDLGFQVRGALEFHPRNKNWILATANGLKGAYLSKDSGMTWKLLRPHVISVKWGARQDKMVSKEEQTILMNVVPNYNGRLNIYNQELWRSRDLGEHFELIAKHIYSFGVQGPFLFVSVDYKKDEKTRIMQVSKDGGDTFENAQVPKIKPEQFYSILDMSEGMVFLHVDDIGDSGKGVLYTSDADGIVFDKSLENHVYTNTDGITDFYKVESMNGTYISSRMNQDNSLSSLISFDRGGEWNPIKLDDKLCKGQTATKDANVCSLQIHNAFSRSRGVNVSRGPLSEASAVGIIIAHANPGYALNKKSIGIWMSRDGGYTWKDTGLRGAHHYAIADHGSLIVAIPVGSEEVRTLWYSVDEGGCWFSYEFPKEKFHLTGLVTSPGAQTMRVSLWGYAGGTRRWMVNTLNFRRVLEKKCMYNKVPDKSDYEEWIPHGNGKNKGCLLGKKITFLRPKPKVLCFNGEDYIPKATIERCPCSMDDLECDYGYYRKVGETKCKLDKTKKPKFCKNGEEIDVESKGYRLIPGDECSSPGTNVEKYVDAHKKCQDQYANYGALTTNEKKSKSSKSLVVAAVVVPITIVALVIAIYFGKKYLDIRKSKPSYQYSSVSQEPEQDMFSSPSHGLDDDDTAMIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J243</accession>
    <name>A0A6P8J243_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Contactin-5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC116305914</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571773.1">
        <property type="nucleotide sequence ID" value="XM_031715913.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571775.1">
        <property type="nucleotide sequence ID" value="XM_031715915.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571776.1">
        <property type="nucleotide sequence ID" value="XM_031715916.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305914"/>
    <dbReference type="KEGG" id="aten:116305914"/>
    <dbReference type="OrthoDB" id="5982258at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653272" evidence="8">
        <location>
            <begin position="17"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="219"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="310"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="418"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="493"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="596"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="697"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="797"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="921"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031571775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031571776.1"/>
        </source>
    </evidence>
    <sequence length="1141" mass="128031" checksum="D456582A532D1884" modified="2020-12-02" version="1">MISFCLLLVLFLKACASNSKPVILVQPSDTVIIGFSFTLMCISNSQNNTVTWFHNNKIIQFHRQQDMMKTADGSLFVSNALVYRDEGFYQCLVSNTRGAVFSRRAKVKFPYLKQFAKGNEFIRKEESHSVVLKCIAPDSYPDRQIQWSKIDPQNRSLRKPLPQSPYYTVSSNGDLHFSYVKSRDSGDYVCTVTNNVINRHVVRTLVLTVYPVLPLVNQPPMISTEFSLTKVAMKGEQFALECIVYGMPVPKITLRKKGLHMIIGQIAGNARRHIIKSFSSSDAGRYRCKATDPSGRSDSRTTTVRMEAKPEWVKKPSDVIVGNNSTISLPCEAFGIPRVHYQWYFNGFALKPSAKHSFSGGNLTLSRLAYSDRGMYQCVVTNRHGQMISSAEVMVAEIPAGFGPGSKAPEDINKLIRSTVTLPCNPTGNPKPTVRWRKGSTYLRKNPRYLFMANGNLRIFNLTRFDSGRYTCEVSNRLGSNSRTARLNVQENLAITTLPKDQMAKIGSNVRFTCGVSTMGVTEVTIQWSRYYQPVIPNSRITIGKSGKGMSYININGVRFSDAGLYSCTVSTPLGSVSSKSSIEHAILQVQGPPDPPKHVKVSNVNSRYKVNITWSLGRDNYSPITRVIIEQKVYFYPRVWSLVKTITDPKETRVEVTMSPWARYTFRAIAVNAIGSSRPSAETATIITPPNAPDIPPQGIKSKGKTPSTLQISWQRLTLMQQNGPDPFYVVYYKKADSKKSMKRHEXRNNRTRFTIKGTKYYTKYAFQVQAANKRGFGPKSDVQYGYSGERYPVGRPTKLKITITSPTSAVATWTPVSNKRDIAGGKLLGYXVYFWTDDFDYRPRKAKFKSTVRATAVLQLDAFTSYRFQVLAYNSLGDGPGSSIVGPLRTPMGSSITDSKSAKRHSETNSKEAHLLPEPPSHLTLVVQNASYVLLQWAPPKTSNGAIMSYTXSVRRLVDSKTVSKTTNFSTELRVHNLDLKTRFQFSVRAKNTIGEGPPVMADFDLATIPLSWPDNVQALYDGFQREATISWDKIRKLRVDGYRIYYFKKEGKLETIDVERDRTEWTIPRLENGNDFWFQVAAFSLVDGEHYMIGPRSPAVKAGKVVVSARKSSGSKILSQLSLLHPICVVILFYQLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2T8</accession>
    <name>A0A6P8J2T8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain-containing protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573932.1">
        <property type="nucleotide sequence ID" value="XM_031718072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2T8"/>
    <dbReference type="GeneID" id="116307764"/>
    <dbReference type="KEGG" id="aten:116307764"/>
    <dbReference type="InParanoid" id="A0A6P8J2T8"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573932.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17752" checksum="B65BEA31B3B76422" modified="2020-12-02" version="1">MNKSNISKSKEFIEKERKSREGLRLSIERELVGDMIRLLDDKLYCDITFIIDDDDFPAHVAILCARAPAFSQKFLPQLLTPTAVQSCIYIQNIKPEEFSVFLRFVILVKIVKNMKNMDVFSISVFSWVVWQLSAIYLVSHLSRVYCWGLPLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5W2</accession>
    <name>A0A6P8J5W2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307263</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573288.1">
        <property type="nucleotide sequence ID" value="XM_031717428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5W2"/>
    <dbReference type="GeneID" id="116307263"/>
    <dbReference type="KEGG" id="aten:116307263"/>
    <dbReference type="InParanoid" id="A0A6P8J5W2"/>
    <dbReference type="OrthoDB" id="10321504at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573288.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17900" checksum="C1D7FA2CE87EE40F" modified="2020-12-02" version="1">MLEGTKDRIERIRFLRRIDANEAFRQDLHAANARLLKQNLSMSEKIIKLQEQIQATQKKTEDQNTRYYYMKKRLQHEEREKLAFVRKNVELKDTIKDFQHQLQEELIKNAKLDARVNQALELLEKDRQSSLRKSLRSIRQWLRGILHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J614</accession>
    <name>A0A6P8J614_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide FF receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116306840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572820.1">
        <property type="nucleotide sequence ID" value="XM_031716960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J614"/>
    <dbReference type="FunCoup" id="A0A6P8J614">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="GeneID" id="116306840"/>
    <dbReference type="KEGG" id="aten:116306840"/>
    <dbReference type="InParanoid" id="A0A6P8J614"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031572820.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45061" checksum="97A6DBAE2F034D12" modified="2020-12-02" version="1">MESKSDVNASVPTNHTADFPSLGESVEFRSIKISFYFLILFGSIFGNGMVAYVICSTRKMRTSSNYLILNLAICDILTPVISIPFDFVLEDNGYVWLYGGFLCKTLWPAATMTATSSALTLALISFDRYRLIMHPFKPRLTSKVIKIAIICIHIFAAIVVSPYASMLELQNGSCSEVWPNVYRKCYTVVLFLVQYGIPLPFMVRMYYLALKNLYKSTRKTSIMQAPFIDFSKDQKKKSRKERNENANRKRRYSESQLKENQSNKKATKMFITIVTIFAIFMLPNQLVWLWADFGDGFSIQGFEKAVIICWLFTYCNSVFNPVIFTIFSSDYRNGFRRILSYLYDKMSGAPNKETRKTSNTSRCTNISVADEQNGTTLRLPFDSIEKNLTSKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J635</accession>
    <name>A0A6P8J635_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC116308840</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575204.1">
        <property type="nucleotide sequence ID" value="XM_031719344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308840"/>
    <dbReference type="KEGG" id="aten:116308840"/>
    <dbReference type="InParanoid" id="A0A6P8J635"/>
    <dbReference type="OrthoDB" id="5949053at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="43"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575204.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="40072" checksum="04D85355F6CA3A28" modified="2020-12-02" version="1">MWQKLVVEHKLSVSKDFVRNALRIMDPEGVDRRLKHRLQRRRYHAKGPNFIWHLDGYNKLKPYGFCIYGCIDGYSRNIMRLEVGRTNNHPGVIASYFLDCLQNIGCTASVIRADMGTENVRIAAIQRYLRLEADDSSSGEKSFLYGRSVTNQRIEAWWGQLRRGASNWWXLTHFKDLRDRGLYCDANDVHVECLLFCYMAVIHEELQKVARLWNLHRIRPSTRNNSSPHGRLYLLYHYPEITGAVDCKHDVDNDELDVAREMYCDDLPMCSSPEFNELAELIMTEGLRMPENGNDARTLYLTLQRDREIDVASQIHRLNTVNQKTMHYALFSNSTIIHDFMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J745</accession>
    <name>A0A6P8J745_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116307538</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031573673.1">
        <property type="nucleotide sequence ID" value="XM_031717813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J745"/>
    <dbReference type="GeneID" id="116307538"/>
    <dbReference type="KEGG" id="aten:116307538"/>
    <dbReference type="InParanoid" id="A0A6P8J745"/>
    <dbReference type="OrthoDB" id="5951403at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="159"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031573673.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40746" checksum="0E569BE6832B0A65" modified="2020-12-02" version="1">MAYELRNSRRLRRPRNAKVPAPAHDFETVSRSSKGIAGRKRRFCVDEPRNNLSETPFKKPKVARKKTSKNEVGRLGRKRCFSGDEPTNETPIKKTKITRKKSEKPESKSTQDSNDKIQKPKYAVQVKPRSRRHRRKQKQEKLMQILRRLTRKDRFLRKYDQQDLIGQGSFGKVYAGIRNDDGLPVAIKYIPVQNVDYNVRVNSDDTVPAEVYFLKKLKHPNIIKLLHHYEFENHHVIVMERPRDGISLFNYLGKRGGALEEREVKNIARQLIPAVMYLEEMGVIHNDLKTENILLDEDVGRVKIIDFGLACKLSCEPIHRFVGMWDLFIKSILELIESTAHRVEMWEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAC4</accession>
    <name>A0A6P8JAC4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116307638</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573775.1">
        <property type="nucleotide sequence ID" value="XM_031717915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307638"/>
    <dbReference type="KEGG" id="aten:116307638"/>
    <dbReference type="InParanoid" id="A0A6P8JAC4"/>
    <dbReference type="OrthoDB" id="10002522at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042622">
        <property type="entry name" value="Znf106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14435">
        <property type="entry name" value="ZINC FINGER PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14435:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="1964"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="942"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1408"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1515"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1636"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1710"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1411"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1538"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1636"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1687"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1717"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1742"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1765"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1792"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1808"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1840"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1880"/>
            <end position="1892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573775.1"/>
        </source>
    </evidence>
    <sequence length="2275" mass="252282" checksum="B71466F05D477211" modified="2020-12-02" version="1">MDEEDRTANDITVASMAGDFFCELCKLEFSTKEELQEHTWTMLHHGKLNKAKGRDCVHECTLCKETFVELLSFTKHLHADAHQERYHTWKKQQRSKDWEALNQMRVPSSVEVSGNTSYRNRTRHKRKNSNGKDISFRTRHQSQRDARGWQHHRKGKGNRNPRHFQKHGNSFQFQAFPVGGSEMGHKRDFGIMNESMGSEDRFGRSSGSIRSESPFLGQEQYFNFHPQSQESTLSDNPTNLPGQANQSDSSWSSRLRRARDQFSRDATERKSLDESFPRESRGFSGSPDSSIFFSRVGENGNGCPKRASPVMGVPSRTCRSDNMTSRSGRNHNEQINDSNIYSEFVPEKSRNSFGNRQNRTRHFKNQTWVSENQRVSTCAGQNFGSSNTLSLENSDALHDNPKGVTTRSGAYFGLRGSQRQSDSFKKFNQTLFKDNQPRKKDLGNRDSRVNNQEEPSDVGRSFSHPTDGKNVEQGAYFTHGFPDPVTGSPEELKAEVITSEQIPLSRVGSSEDTRSIRPRRIRDSDDNRDMNLGHSLKYFTDSNVELPSDEFGVQSRGIKAAKSHPNKSCVTETSSIRRTSPRLRRDNYVTQPQNSDISSVVGSSAITNTFINAEQKEPTLGNNLMADEEVERLNALIKMKKERTDPSEDAEATDNPDDGNVQERLESTHGEASDAQARCSFVHIDGVQCEALTSERYCSYHQRFPQGNLIKTEPGIEHQQAVPTNTTLLSNSSLSPSALPRDLPKDRDAIPRGERSGISNMISTGRQSESLGDIDNKDVDHKHSSTKTVIKRRESENHENTPSRHPLQSGIYFHGKEQVSEDIKSQRDARTESSDNTVSKTSSSVEMMDLSMSTNFLVLPHSQVATSTTVKPTVTNRTTSSWRPNAGAQPWKDTVQSGHGYWDFANSTTVVVSSSSSIGQLREKTAPKWSSNAIVKTERQFDVPVSPASTPPSLTEARKSSVSPVSPSVRKESNISPISVTSVPSLDLSRLNLPPHVRRALALKYANKKQADGVSLAASLAPNVSSSRTRFVEAKKCLAPNQEQTDTTLKLTDTLLRKPPITSSAIQRRLRQHRSVSLDSCPTSRSSFFPEVPNPCDRLGSTSYERFPTGMSSVSGPHVFKVSSTMNANKGENVPVQPMIDLSASSYIPSLQQAGASKKRHSYKDHEATTAYRLGKPEVREFSGTEGGFSLDKDKIHKHQRTSSLENIPSLMPTARRSVRAASFDRDTSYARFDAGGSNPPQTSRLVPATGMIKKDGDQFVSGVHSLSSATHEKETSQSKFATVLQASPRSLIVTPLPSEKNSALISLESEVSIARSLEGTEHNDKDGGYISLESTARSATPEGTTDNVVRLHQYGLLDLGSTRKTSSIKNDEATRAASLHDDSRPGDFIFPGMSNYIGANRYDFLSSKRKTTDGSDTEERNKRTKSVDSSTSGNESLTYLPGVDVQELLHLEHEEQKQLKSLQDIQAKAKATRLKLQALSIELEHLNVLEKRISEDISNTKNKRLEILQGALRGGRGKTGEALHTSAQTSAEDKTSSQKNVENAEKNSNVSDVIGFSSTSDAQGDSTKTLGYDCNIGSTRTDPAKEDQTVSICEAPTSAIGIDLVVKTEVESVYPCVESSFSTTETCQVVPRPEIKTEGVIDRQETSAADQSEHMETDHDVPCDTLSRPHDPQGASKDCGISPESPSKDKDEWVSEHFEKSRKEFFEKIKQQLGTPKKRQQNKRQRKRFSETKVSNSLAVSKERLQLVRERMRGWKEKGHALDSTHSQRSQPPSEEVVAGEDHEDVDHPHTSSNTYKDTNLTPSKIPVRDVGDSTKDSTNELKKSNSTDSRAKTDLKVKLKSKMNAKKKRKSLHPTKKASSRPDKHMKSTADQPQTVSQKEKSKSSDERVQHTVAAESLKKKFERMSKASKSLSTSKARASVFEGHTGAVCALKVSQGKLFTCSADKTTKSFDIQTGECVKEYIGHHHAVNCLEISDNGERLFTGSNDQTVRSYNVKTGICSHKFTFDGRVMCLHIGFGLLYVGLSTGIVTLVDLTTNTCVERLRCHEPRAVSCLATATEGQRTLLCTGSFDATISIRDHKTGLLFKTFTGHSMTVLSMQVVDNVIYSGAADAKVLAHNLNTGELLRSYTGHTLSVSSLQVAGSVLVTSCLDKLIRCYDLMSAELLQAYGGQSDMIFSVHLSNGRIYSGTRDGKVSSFKLDLRVYHPCKWKDCQLNFGIVSHMKDHIKDFHIMQQGAIDKCLWADCGHVFGESDNIETILDHVDAHLKSSKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JB86</accession>
    <name>A0A6P8JB86_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307810</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031573990.1">
        <property type="nucleotide sequence ID" value="XM_031718130.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307810"/>
    <dbReference type="KEGG" id="aten:116307810"/>
    <dbReference type="InParanoid" id="A0A6P8JB86"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF49">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573990.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="36427" checksum="B41CA92141EB961B" modified="2020-12-02" version="1">MWRMTRLNFNFARLFFCTKRANLIXNQARGFSNGVLLSEDEIQRFKEDGAVCLRGKFDQEWLHNIRRGIRKVFDNPSRFSEKLAHKEHSKSLYFNDFWNYQTVQEFSEFVFHSPAAELARQLMGSENVLFYHEHVFTKDPGTCFATPWHXDQPYYPLDGWKNCSFWMPLSVVSKENCLKYIKGSHRWGKWFIPKKFETNLNYSLQDKEMGRFSXMVDIDANHDQYEELSWDLEPGDCIAFHMLTVHGAPESVDQNGRQVLATRWLGDDMVLTTRPWECSPPILPDGFKAGEYVLKYQHAFPPIKQKVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JBY5</accession>
    <name>A0A6P8JBY5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Beta-1 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC116308802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575153.1">
        <property type="nucleotide sequence ID" value="XM_031719293.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575154.1">
        <property type="nucleotide sequence ID" value="XM_031719294.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575155.1">
        <property type="nucleotide sequence ID" value="XM_031719295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JBY5"/>
    <dbReference type="GeneID" id="116308802"/>
    <dbReference type="KEGG" id="aten:116308802"/>
    <dbReference type="OrthoDB" id="5980742at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031575153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031575154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031575155.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39929" checksum="18493500DF5E64B7" modified="2020-12-02" version="1">MENNTSKIEETDEMEEDHDESAKGFEAVVDTFPIILAVFIIIANSLGLVLFARNRRLRTITNTFLVSLAISDLLTGLFGIPFYLICSAVTQQDYCRTAMLCWRFTSTSTVLHLLAVTLDRYAAIVHAIRYHTIVTRTVAKTTILMIWLTSFFVSLIQLSWQPNDEELSEMSDEEMEQAWETYKRKTSIYLVSTLLIFFLLPLMVMVYSYVRIIIIVRYHEKQMKKHNMPSTRGVGEPLQKKNSSFNIQAQWKSAIVFLVMILVYVICWLPFFLYSLREQLDLFRLPHWAEYVFFYYPRFVTSLSNPLFYIIGKHDFRKALCPKKQNHNGTQMTSLIGRGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCB7</accession>
    <name>A0A6P8JCB7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116308011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574220.1">
        <property type="nucleotide sequence ID" value="XM_031718360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCB7"/>
    <dbReference type="FunCoup" id="A0A6P8JCB7">
        <property type="interactions" value="1631"/>
    </dbReference>
    <dbReference type="GeneID" id="116308011"/>
    <dbReference type="KEGG" id="aten:116308011"/>
    <dbReference type="InParanoid" id="A0A6P8JCB7"/>
    <dbReference type="OrthoDB" id="409897at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990535">
        <property type="term" value="P:neuron projection maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031574220.1"/>
        </source>
    </evidence>
    <sequence length="630" mass="73600" checksum="12FCA63543F31306" modified="2020-12-02" version="1">MADVGEVEVGLDSKIEEVKNWLKSEGYDKYKEARRLTEEEAKNDPESEPYKSKYAARDIWIELKEKLETFQSEDEECSEFTKLLLASLNYQLGLNYLETQEPGLGEKCLQQCLASLRKDDNLEVKSASLILHSLNQLGILWSQRGEEEKSLEFFQDGEKFYHRFKKDVGGSPYSIHELFNADENSLSDLDRVKEFEAAFTHTLYYLAQVHGALGDSKKSGTYCHTTLQRQLETKQYDPLDWSLNCATLSQYYITCDNYVMARHCLACSSVVLAEAEEKYTHESVREDDGELERQRKERFPRTRADISRCWAKYCLNLIKEGKEMKEKEMDDRRMERENENDTEENNEGEASTTDRVQEREEEVEEEEDDEENKNPLRFTSLEVTCYEQSVPHHAIKNFNEARTIFREGQKWLNQSKDYYLLDGHVSDFVQIQQDLSQFYKLLAFFEQEKDRKCKMHKRRVDLLSEVLCELNPQHYLQICRQLMFEIAEAYSEMVDLKIAILAETEQQPPTVHAVKKINHLINQAIKFFQTFIDSMKQKGALPETYDDDIVRPALVSHFCIARLFSKFVGLETRAKLENLKKSVDLYNYIVSYCDNHPDMPKESFEDELQISRDMAALLPIKMSKIMASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JDB1</accession>
    <name>A0A6P8JDB1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Vesicle-trafficking protein SEC22b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">SEC22 vesicle-trafficking protein homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116308260</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus</location>
            <location evidence="16">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574505.1">
        <property type="nucleotide sequence ID" value="XM_031718645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JDB1"/>
    <dbReference type="FunCoup" id="A0A6P8JDB1">
        <property type="interactions" value="2691"/>
    </dbReference>
    <dbReference type="GeneID" id="116308260"/>
    <dbReference type="KEGG" id="aten:116308260"/>
    <dbReference type="InParanoid" id="A0A6P8JDB1"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="21">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="22">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031574505.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24936" checksum="362FCEF27A05E186" modified="2020-12-02" version="1">MVIMTMIGRVTDGLPLAASMPSDQETSRGLQEYQGQSKLLFRKLNEHSPARSSIESGPMMFHYIIENGVCFLTLSEKAFSKRAAFSFLEDIASEFLREYSSKIPYASRPYPFIEFDTYIQKAKKNYQDSRTRRTLNRINDELVDVQRVMVQNIDDVLQRGEQLSVLDDKAGNLRFQSEKYKKDATYLNLRSAYAKYAALGIVCTIVIIYIRFWWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1H3</accession>
    <name>A0A6P8H1H3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Remodeling and spacing factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116286805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549251.1">
        <property type="nucleotide sequence ID" value="XM_031693391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286805"/>
    <dbReference type="KEGG" id="aten:116286805"/>
    <dbReference type="InParanoid" id="A0A6P8H1H3"/>
    <dbReference type="OrthoDB" id="10055895at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF16">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="776"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="481"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="528"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="556"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="698"/>
            <end position="711"/>
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        <location>
            <begin position="776"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="804"/>
            <end position="842"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031549251.1"/>
        </source>
    </evidence>
    <sequence length="896" mass="100484" checksum="4D9F6C21DF6CE83E" modified="2020-12-02" version="1">MASTGSSDAEEDIQDQSFSPKKVGRAAEYPEFAIIWSYLENFCELLRFPELSLDGLEDGFNSHSSRNENYRQLEFLYKKLLVKLHKNFRPEKWEKALLKVAKEQNMLSSWDLENFGYDELKVCTKLELFKMLLESQFDCNNKLKTEVNKNYEADELRLRPFGRDMDGLLYWFHMDECGGVRLYSTEEDEVENESWKLLASDLDELGVVVDYLALKSATNPKDIVMAKREEERKKEAANSKSKKGKKSKKAAVKEEDDDDNPCARCYSNVHPDSILLCDKCDAAYHTACLRPPLLNVPQGDWFCPFCQQLVLLERLKEKKTRLVARQKLRARQAKRLDKSGMNLSNILQGPNSDEEQIDTIRRSGRARKTVDYTFRDFDEEIKDAVEVDIKSTEMNGHPTGKPAFAVDRFYTGRSSSKPASRVGKRRSRRLKDLDSGSDTDSKYSDFDYGASSDDDRPKPPKRHVYLRRHIIEDDEEEDENEEDKKQEETTIEENGDKEKTEQDEVTDEGDRGMNEENSSKDVKEKESNDEPTEGTLTNEQEKAEKSSNDSRVSGKEGEEDTSSEKSGPTIKTPSLKTVKDSETNCKDNSEQDKVTPEEKKQVDDSNKKKAHSDQHKKGFLEVPGPQSKPPPLERISSPKIDPLLDSLGFGALASCFTSNERLPARPDPYGTLRSPTASRSPRSPLRXDPGFPTDRMGVSRVPSSPSSYPRVGADSRYSFPDYGQASSYGTYFGYNQSGLSTGTYPGSPPGRPPSYSISMAGSRQYPGYDQAAFSNRETSAFSQTPQSPSYNQSSTPAMTPFGNPLSTGYPTAYSDTGSRAGYYQSSNQGYDIPSKSSYSHPSQGYYPDDPFSAGMYLGNPTANPLPPGGINSWPTPPPGSGSYFPQSGMGQNRTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2T7</accession>
    <name>A0A6P8H2T7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Partitioning defective 3 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116287379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAR3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549913.1">
        <property type="nucleotide sequence ID" value="XM_031694053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2T7"/>
    <dbReference type="FunCoup" id="A0A6P8H2T7">
        <property type="interactions" value="1392"/>
    </dbReference>
    <dbReference type="GeneID" id="116287379"/>
    <dbReference type="KEGG" id="aten:116287379"/>
    <dbReference type="InParanoid" id="A0A6P8H2T7"/>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23058">
        <property type="entry name" value="PDZ2_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="518"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="634"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="835"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1223"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="773"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="850"/>
            <end position="899"/>
        </location>
    </feature>
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        <location>
            <begin position="1003"/>
            <end position="1045"/>
        </location>
    </feature>
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        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
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        <location>
            <begin position="1090"/>
            <end position="1103"/>
        </location>
    </feature>
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        <location>
            <begin position="1111"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1245"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031549913.1"/>
        </source>
    </evidence>
    <sequence length="1275" mass="139910" checksum="E2283DE317AE02F1" modified="2020-12-02" version="1">MKITVIFDSVRVIVPCGNGELSVRDLTQRAVSRYKKATNKHPDDYVEVQVLETCEEQGILDPDDVVADVLDDKEKVIAVFQEQSLNRPYHNGGDGMSTSSIGTASPDIFQAEISSINNDSKMRSISPEKDENQNITSKLIVVSSAQIREKPQPPPVAPKPNISRTKEPSVPTVDSDSGIYVTSSRTCFGSDSSKSEVSEPISTPRVMRMSETAFVAIGTPIIAPNKPFNFNVSNNNNTRNTSTSDFEQMDDDEEDGQFSLGRNSARQSMFIDHPALDRWAEFQEKRMYEERENSQGFVSADEREEPAGASMSPTDDITFDNNMFSNECLDKQDGVSNNSFYSGDSDESLAIELHPQTSGDLGFTVAGYKTADGRELGLIVRNISPDGCAARDGKLQIADRIVEINGSNLQNLSNKRAEEIFSESIKVPVVKLVVSGSSTFVHEERISKDDTEEDKNTVQEVTVAEQVLEQETLPAQYSVSPEPNSGIEPPPGFRDDRKAQMNGPQLSSNVKKVNKKILLELNKGSDGLGFSITTRDNPAGGHTPIFVKSILAKGAAIEDGQLKSGDQILEVNGTKMTGKSQGEAVNILRSTRGLVKLLIQREELIQSATKPAIQVNEESTRNLREQGKQVLTFKIPLNYTGAAGLGVSVKGKVDELEDGRDSPQDKGIFVKSVIAGGAAQKDGRLQADDQLLSVNNVSFLGVPNSEAIDRLRTSMQSTRLGQAFIEVTIARDKDDDGKDMVDFHQPEQERPIEAGSPSPVVTKSVPVVQQNISYQNVPQVPRTSLDQGSLDDDDEDDEFSEEPVALNFSVAKSRNIVQRNESYCFAVTKSKQPYRRSPLITREPARSSGALRTSMSGNIPNRPSSTVAMPTPPLGSTQDRSAVNDGPDSQSNVSKVSNPTPVPPPRVDSYNSSVIANYQIHQQMANGRYSKLNANTSQDQGTIPPAVPQPPLLIANEKEKLLSAYPKGYERTRSSESETMDNEVFNDSKDVVFAGSELPDDNPFDREGFGRQSMSEKRARASMDAKKTEIYQKRERQKLAEEKQKPTKTRPSSSYENMNCEGTPSPLRKAKSEGHMQAAAIDAQVSRKTSSSSPMLISTSDSSLRPGVNGKTRTSSGSTSNLSFRNAIEGASTSSLGRDMPNGVARQSQSDDAQDEIPITMTSKADFNAVQQKLAKKPFYRKFKIGKTRRGEYNISDIERSPKHSIYSQEALIDFPSEQRYRQLVSHYDESDNRPNSMPSRGRKSGKDQNDGKRLSNQPSSNKIGRVIMSEPTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5S7</accession>
    <name>A0A6P8H5S7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116288167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550778.1">
        <property type="nucleotide sequence ID" value="XM_031694918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5S7"/>
    <dbReference type="FunCoup" id="A0A6P8H5S7">
        <property type="interactions" value="1685"/>
    </dbReference>
    <dbReference type="GeneID" id="116288167"/>
    <dbReference type="KEGG" id="aten:116288167"/>
    <dbReference type="InParanoid" id="A0A6P8H5S7"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003977">
        <property type="entry name" value="Guanine nucleotide-binding protein G(q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF329">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550778.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41541" checksum="51E868C6D3224BAC" modified="2020-12-02" version="1">MDCCCLSDEAKERKRINAEIEKQIRQDKRNQRRELKLLLLGTGESGKSTFIKQMRIIHGQGYSDDDKRGYIALVYQNVITAMHSLTRAMDTLKIPYKDPANPERANYIRTVDPKNVTTFEKEYYEATKNLWVDAGMQECYDRRREYQLSDSAKYYLTDLDRLAKPDYLPTEQDVLRARAPTSGIIEYPFDLETIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDSENRMEESKALFRTIITYPWFQNSSIILFLNKKDLLEEKIMFSHLVEYFPEFDGPQCDAQAAREFILKMFVDLNPDTDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H615</accession>
    <name>A0A6P8H615_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin accessibility complex protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA polymerase epsilon subunit p15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116288226</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with POLE3; binds to DNA. Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity. Within the complex, the heterodimer with POLE3 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction. Within the complex, the heterodimer with POLE3 interacts with BAZ1A/ACF1; the interactions are direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550853.1">
        <property type="nucleotide sequence ID" value="XM_031694993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H615"/>
    <dbReference type="FunCoup" id="A0A6P8H615">
        <property type="interactions" value="1296"/>
    </dbReference>
    <dbReference type="GeneID" id="116288226"/>
    <dbReference type="KEGG" id="aten:116288226"/>
    <dbReference type="InParanoid" id="A0A6P8H615"/>
    <dbReference type="OrthoDB" id="1291358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22924">
        <property type="entry name" value="HFD_CHRAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000048">
        <property type="entry name" value="Chromatin accessibility complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="13">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031550853.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13596" checksum="8E9924F3A7A20EB0" modified="2020-12-02" version="1">MADEQQSPSEKDGKLNQLPLSKIKTIMKSSPDLVNVSQDSVFLITKATELFVHHLTEAALKRGENKKQLTYKALSNLVDDEDNLQFLADIVPPKVLYKDYLASLKKDKSEAIEVDSSSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6E8</accession>
    <name>A0A6P8H6E8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116288304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550938.1">
        <property type="nucleotide sequence ID" value="XM_031695078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6E8"/>
    <dbReference type="FunCoup" id="A0A6P8H6E8">
        <property type="interactions" value="2726"/>
    </dbReference>
    <dbReference type="GeneID" id="116288304"/>
    <dbReference type="KEGG" id="aten:116288304"/>
    <dbReference type="InParanoid" id="A0A6P8H6E8"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10497">
        <property type="entry name" value="MH2_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="10">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="11">
        <location>
            <begin position="244"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550938.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="49369" checksum="8654804B8E64A5D2" modified="2020-12-02" version="1">MATMASLFSFTPPAVKRLLGWKQGDEEEKWAEKAIESLVKKLKKKKGALEDLEKALSNPNQPSKCVTIARSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEYAFGLKQKEVCINPYHYRRVESPVLPPVLVPRQSEYPRPPPPLPPPFRAAEDPPMPYNASFPFVNRPRPSTAEQSPQNSFEISESGTGYMSEDGGSPRPDTMDVDSPTLPMNPSAADVMSHVTAVNYQEPLSWCSIAYYELNNRVGELFHAKSTSLIVDGFTDPNTSNSERFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSAIFVQSRNCNHSHGFHPTTVCKIPSGCTLKIFNNQEFAQLLSQSVNYGFEAVYELTKMCSIRMSFVKGWGAEYHRQDVTSTPCWIEVHLHGPLQWLDKVLSQMGSPRNPISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6U4</accession>
    <name>A0A6P8H6U4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G2/M phase-specific E3 ubiquitin-protein ligase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551073.1">
        <property type="nucleotide sequence ID" value="XM_031695213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288426"/>
    <dbReference type="KEGG" id="aten:116288426"/>
    <dbReference type="InParanoid" id="A0A6P8H6U4"/>
    <dbReference type="OrthoDB" id="5965602at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551073.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24781" checksum="7AD2C08C73D6EA48" modified="2020-12-02" version="1">IIYAGDEESFQKLLNEEADFILEAGITKVNWKLEDKDQLATLLCKSHVIYKAKAAIDQFLEGLASTGFLKYIKENPYSLKEIFCVSNSDVLKVSAFRTLLHAHLTNPGXNDDNKAREEEEATMLWWEEFLDNIENSDHKGLLIQLLIFITGANKIPILGFHKAIDIYFYQYESGVKRFPTASTCALTLYLPRGIQSYDEFHDLIVQAIKEGSYGFGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7I2</accession>
    <name>A0A6P8H7I2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116288596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116288596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551263.1">
        <property type="nucleotide sequence ID" value="XM_031695403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7I2"/>
    <dbReference type="GeneID" id="116288596"/>
    <dbReference type="KEGG" id="aten:116288596"/>
    <dbReference type="InParanoid" id="A0A6P8H7I2"/>
    <dbReference type="OrthoDB" id="5984204at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028086338" evidence="8">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031551263.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29096" checksum="B15A9F517695336D" modified="2020-12-02" version="1">MYTSYSQVLRVLVLCFLLVTCRTFEYCKKIDAAKCETDEGTIDLWKLARSDGQPKFKDIPDNKVSNQYYSFNPGKSWSDTRRQTGDFNSCQNIAACMRYSSSSAGDSIYANIGTQSSVDFIHNPSDGTCTMSLKGQYLSTNTKTLITIICNEEEEGKLDLFVADERSGSWTYTSTLQTKHACFSPLSIGSIILITFVSVVVVYFVAGIVFNKFKRGASGKDICPNYGFWSDLPFLVKDGIVFSVQTCRSKVSGRKEDYASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8D4</accession>
    <name>A0A6P8H8D4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548700.1">
        <property type="nucleotide sequence ID" value="XM_031692840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8D4"/>
    <dbReference type="GeneID" id="116286358"/>
    <dbReference type="KEGG" id="aten:116286358"/>
    <dbReference type="InParanoid" id="A0A6P8H8D4"/>
    <dbReference type="OrthoDB" id="5980626at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031548700.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27672" checksum="7D9BDEA5F2693D88" modified="2020-12-02" version="1">MARYSSDSDDDRRSKEKRSKSSRKRDRRSRSRSRDRRRRSRSRSRSSRSHRRRSRSRSVDRKSSEDRYYSSKKSRSDRDRRSRSPGSSRNSEERQREKRDKDTAVEKTKQRIKEALSQAETNDDDLLKAKERKKLGKEVIPNADAIAEIESNEFVQQSFTSSYKDKQSTVDKSQPDILISSTKQTPVVPINVFMDASNSEGLFAARVLEDESTKMERWIKKMTATRNKMLAAGSLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8X3</accession>
    <name>A0A6P8H8X3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proline dehydrogenase</fullName>
            <ecNumber evidence="6">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116286778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031549212.1">
        <property type="nucleotide sequence ID" value="XM_031693352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8X3"/>
    <dbReference type="FunCoup" id="A0A6P8H8X3">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="GeneID" id="116286778"/>
    <dbReference type="KEGG" id="aten:116286778"/>
    <dbReference type="InParanoid" id="A0A6P8H8X3"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 6" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031549212.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="68599" checksum="FD5F78E4C6E40B6B" modified="2020-12-02" version="1">MASKLFGNDALKYLRLPLYRNLGVRCQSIGSASTHIDKRYELENAKRENVTRFAFDNSREAFRSKTSLQLLRALLVFRLCSINFLVQKNQQLMKLGQRMLGKGLFRKLMKATFYGHFVAGEDHEAIKPTISKLEQYGVGAILDYSVEEDLSEEDAQKAMGNDQVPIDQPKALADNPDDYKKYRSYKQFADRRKGVVSARTYFYSGEPECDKRLETFISCVDASGGSSSDGFAAIKVTALGRPQLLLKVSEILNQVQNFFDQLAKGSAIQNKIGSSIAKDHFFEGLDRLGVHINQDEADHIFDLIDKDKSGDIDVIEWHEFLTPQLQLSHLFKAKPTGNEKSGKPIISILDKDDLRQIQNMRDRLTKLAKHAEDRGVRLMIDAEQTYFQPAIRRLTLDLQRDINKDRPLVFNTYQCYLKDAYRHAQVDMELARREGFCFAAKVVRGAYMEQERLRAATLGYTDPIHSSYAATSDCFDKTMNSIIEQAAKGRANVMVASHNENSIRFAVQRMEELGLDPDSKRVFFGQLLGMADQISFTLGNAGYSVYKYVPYGPVEDVLPYLSRRAMENRGLLKGILKERAMLWEEFRRRGRENQLFPLNASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAM4</accession>
    <name>A0A6P8HAM4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116289860</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552656.1">
        <property type="nucleotide sequence ID" value="XM_031696796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAM4"/>
    <dbReference type="GeneID" id="116289860"/>
    <dbReference type="KEGG" id="aten:116289860"/>
    <dbReference type="InParanoid" id="A0A6P8HAM4"/>
    <dbReference type="OrthoDB" id="10355225at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF24">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027953358" evidence="10">
        <location>
            <begin position="24"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031552656.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52788" checksum="0ED2A98E00B981B5" modified="2020-12-02" version="1">MYVILLSCLAAVILQLLPPVVLISSPTKLTREVGQDVVFMINSTVMSEATWGVRDGDTNADLNPRLYRVFNPGGAFPDTKINSTTYAGRVSFVGELTKGQAWFKITNLNINDTNQYMARVILQGESSYRFSSATRLNVIQTVVPATTIPLQTSTKGLSTTASSSKTSLRPTTQVPQISNRSISIKIVKKMSGNVSDANSDAFKTFSEIFVSEINIIYRNIDNFEEANVTSLSDNIIPVKFVVFFKNTIKPDEICAPLKDAVKDNRLGRFKIVPGSLECSNEPSTNFPKNQSSSACTCTSIIAACTTIIIFLILVVVVLLFYIWRGRSHAEKGAESRRSSSVKDKDLESYENVHQMEDTSQRTTTKTARASNEKEIYETIKENRNKDTAAIKANVKPTPGPSVGVQGDVPPLPQHYQDLQIKATHSTPLYEPLKQRGEFGSKGELAPEDPKTYEHLQQSASGREYQSLKRYKDSESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAQ2</accession>
    <name>A0A6P8HAQ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Unhealthy ribosome biogenesis protein 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552691.1">
        <property type="nucleotide sequence ID" value="XM_031696831.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HAQ2">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="GeneID" id="116289892"/>
    <dbReference type="KEGG" id="aten:116289892"/>
    <dbReference type="InParanoid" id="A0A6P8HAQ2"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552691.1"/>
        </source>
    </evidence>
    <sequence length="1531" mass="173340" checksum="E06213FD9A31FD3F" modified="2020-12-02" version="1">MQGVYTKLRDPQVSWENKISIAQNAWSDEKCFIPNKQQVLLDWVCQKLVDHILYKKDKRPVDGEQISREVKDLWGYFKKILQNISTCKPLNGEDSVHIPLTLMPQLVQVFAKVFLDYSSSESCRFTSEQESDMLNIIHCGQMILSSSQLNTSFVAKFENYVMFMSSLLSLFVVFMININSLTNNEICNEMFHMLELSLSVYNSLQRRQTNHRKLFERTCGHIIGPLLTVRYIVKNIKLHVYQSDAKKITQDKITCFVNLLHRTLSDALFRRENLSDYLSTLKALKDKKDEDDTTEPQSKRACLGNYTKLLFDTLRNLLSCSDGMKQEAVMDILPQLYVDFLKARRENQMASSSLEFDFFTELCVLLGIDIDNTVINKHEKHISRILEYVHYLLDAILIFDVYQVGEDHADDSRQLKWFVKFTKLLLTYQSSFNIYPCLEVLLNLNHCIIVPHLNTILQWMYGSDTYEQDDVSSCDTFLSSVVKTYVKLRQFDRLISQMLESLRTTKTMNGPWMGFPDLVRGELIKACQSLPYGLSTSLWKTVNSEICHHYLPALQGLEEQAKTEHKSENKMDDLIFSLEGVVGLFSLFLLNTTLGGVTEQHTVETTKRTLSSLYHGSVDDVLGPLWEALSNMRDNKVFAQSLSVSVLILFHALQEIKIFLGKLGCISDELNIYWEKYIKGYLQKILRTKKQGNERLQYLLVLLCIQRTRVLLIQDSSAHCQTDFQQLLDHIFILSDTISYDNPSSWNKQVWTVNKTNISLAYWYCLCDKASLFLPVCTGKQRLKFTQCLIQSLVSTDVEPSSVQTRIFENVMSIQSTSKTLLHSAAFHLVPSMQDSLVSSLWIHVGEVLSSCNFTAQPHKKLVNIVTALGTLQVNGSVNDDLRDFDKEEESEDTDSEASEDESVSTSEGEEDISQVAQSTEKSLSKAVSPVLSLGKALDNALEVLESSKGVSSQASEKDLKESLKMLTNCLSMLACLPLDWLTDANHSACIIGLMACNTLLHSCLHQGENKECHRAFFLDHELINIMVNGCISKKRFLIHHVINLDSFLTWMLSSYLTSCQIEREERYLEQLESTSIHLICTLVKYLLKTASPASSVYSCINKMTDGIDGLTKELKKATLPSVTGIVHDNKPLLGVFCGVMDVLEKVIACKTSRLNEVRISAKLATNMAPTLLNLLGTIAAKNDKKRHSIKKGSCDAVKCLESVLQGLPVLIDSYSAVIHIYNVTQTSRKLSQTKEEFQQLQWRPILPSILTFAINSLQSPQQDTLQNATEKLKRSCLHLLDVLCLSLDTMKIDLPHDFHCSLLASLLSFLNKLECEKEENTEMRGKALESILSLLLSSPSDILVVLLKGLSNELTSKPLNENSVHRISTCVHVWSMILSGRFPKLKKKELCPVIPQVLMALQSLLQMSASNIDLIVLTLQAMTKLLSLGTHYVQSHHCSLAFHGSLLVPLNDSKERFPHLFQAQYGLLSSIMFHQSEAVYNSVQVFVTCVKNMLWSLGQHCNNNKTAQGIQDESLKPQLDSELVCAQKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCA7</accession>
    <name>A0A6P8HCA7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550150.1">
        <property type="nucleotide sequence ID" value="XM_031694290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCA7"/>
    <dbReference type="GeneID" id="116287605"/>
    <dbReference type="KEGG" id="aten:116287605"/>
    <dbReference type="InParanoid" id="A0A6P8HCA7"/>
    <dbReference type="OrthoDB" id="5985458at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF14">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550150.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33897" checksum="6C14ABB35908ECCE" modified="2020-12-02" version="1">MQDDGKGEETDSDFGDMKHVSTKGDRSPIIVTVLVEGQELSMELDTGSALSVISKETFHKGRVHQEYHPPVTHLYRGGSKTRWGLQTLARKPEVEQALDELEAEGVIVGVNYSEWAAPIVTPVKKDGSVRVCGDFKVTINPQLEIDEYPLPRIEDIYASLSGGKQFSTLDLRQAYLQMEVDEQSKHYLTVNTHRGLFQYQRLPYGVASAPAIWQRAMDQVLQCRPGVQCYLYDIVVTGKSEREHLDVLDKMLQRLEEYGLKANKGKCKFLQEYLGHVISAEGLRQSPKKTKAIVEMPATRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCT0</accession>
    <name>A0A6P8HCT0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP-dependent DNA helicase DDX11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116287781</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550335.1">
        <property type="nucleotide sequence ID" value="XM_031694475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCT0"/>
    <dbReference type="FunCoup" id="A0A6P8HCT0">
        <property type="interactions" value="1816"/>
    </dbReference>
    <dbReference type="GeneID" id="116287781"/>
    <dbReference type="KEGG" id="aten:116287781"/>
    <dbReference type="InParanoid" id="A0A6P8HCT0"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001050">
        <property type="entry name" value="ATP-dependent DNA helicase DDX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002532">
        <property type="entry name" value="DEAD/H-box helicase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="24"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031550335.1"/>
        </source>
    </evidence>
    <sequence length="907" mass="101864" checksum="7E5F5B68C37E05BF" modified="2020-12-02" version="1">MSLSATKDSNMESCLVKDESCSSVPAYFPFPFPPYDIQEDFMKNLYMVLDKGGIGIFESPTGTGKSLSLICGALTWLRDFEAKRQEDLSKGLSPKDLDQSDVSMKDESKSGDDDLPAWVLDFGAKKKQQELEDQLRAQNEKLEKQKAHLMQVKQDSRKSFVLKGKRKHSEEQTLTTNESKKEDQIQGEIDDLLGKSAAEDPDVDIILKEYHSDDENDDDDKCSDDEDEEVHCTKIYYCSRTHSQLAQFTREVIKSPYGEATSLVTLGSRQNFCINEDVKKLKSNTRINDRCLELQKNKKKDKVEVEKTESGKVTKKKKTTAGCPYNDYKQQQNFRDQLLIGIKDIEQLVSLGEDLHACPYYGTRQAIPAAKVVCLPYNMLLHKSTRQACGIKLEGNIVIIDEAHNLLETINNIHSVEISGAQISGSFSQLSQYLDRYRTRLKAKNVMYIKQILFILSRFLSCLGGKATELGKPLTQQEPSKAPFASKPDVQLKTINDFLFSSQIDNVNLFKIGRYCHRSMISKKLNGFVDKYRPQEVFQESSQSDEPSYQSFTSPMHFIENFLEALTNADVDGRVVVNRQDRVSTSSIKFLLLNPAVNFNSVVQESKAVIVAGGTMQPTSEFKDQLFACAGVSPDLVHEFSCGHVISPEQLLTIALGKGPSGLELDFTYQSRDSPQLIEECGRVLLNTCAVIPGGVVCFFSSFDYAQKIYSHWEKSGILEKLGTRKKIFTEPRKASQVEQVLSSFSALIKKTSASVNQGTQSQVNGAILLCVVGGKMSEGINFSDDLGRCVVMIGLPYPNINSPELKEKMNYLNTNIGAKAGQEYYENLCMKAVNQSIGRAIRHRQDYATILLLDHRYSTPRVYNKLPSWIGSRMQHYSRFGPAFAAVRKFFVDKRSCNKTTTMAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCZ6</accession>
    <name>A0A6P8HCZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550410.1">
        <property type="nucleotide sequence ID" value="XM_031694550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287857"/>
    <dbReference type="KEGG" id="aten:116287857"/>
    <dbReference type="InParanoid" id="A0A6P8HCZ6"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027804603" evidence="1">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550410.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24436" checksum="ABB5D33B16BA2D1F" modified="2020-12-02" version="1">MIVKAMLTWSALFFACVNGLVAQNMAYRRELDKYLRSKFVTFAKRGFESTNKFRSIHHSPPLKWSDKLAARAQKLAYQMALNGTIQAPGIDEIGENRAKLSAVNYDCELAGEEATRIWYXQGSHYSYSDPRLNSDTDSFTQLVWKDSREIGMGCAQRKGSVTNEIYVVALYYPPGNSESTLRDNVIDPKRMSNKDVYATIYRREHMGHDQSNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDD8</accession>
    <name>A0A6P8HDD8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulator of nonsense transcripts 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116288000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550575.1">
        <property type="nucleotide sequence ID" value="XM_031694715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDD8"/>
    <dbReference type="FunCoup" id="A0A6P8HDD8">
        <property type="interactions" value="3024"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116288000"/>
    <dbReference type="InParanoid" id="A0A6P8HDD8"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000014">
        <property type="entry name" value="Putative regulator of nonsense transcripts 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000023">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="133"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="524"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="728"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="6">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031550575.1"/>
        </source>
    </evidence>
    <sequence length="1241" mass="143164" checksum="549C49ED5072F858" modified="2020-12-02" version="1">MSKVKANNHHGAEMGENSSCSEETQGKTSESEENSINKRECEDNSCEKEEKPPATMAEERQECSKEEKEETGQENKKEEENEKEKEERERNDVMKIVNEAQEQINTKLLLRSKNLAAAGSSSDTSLKGLDSSVKKNSAFIKKLRTVTEQQRESLTNEFNGLNLSRYIQEAVTSIIEGLGKLKQADVNCVAHVCSIIHQRYSEFSDLLRKELFKMFEKCGGKDEERAANVSRFRVTLRLLGELILDGVFSLEDSVKSIRDILSNVINCDKDSHVYVQVVISFARHCGEHFAGVLPRRQRQFVEKHNVIWPSTGVIPAEAQSAFCTLLRNYYSSLAKHLLKAHKDLQNRERQNREILHTKGELHVERKEALERAQKAYDKLLNSTSTLADVLDEEMPELPADEYSQQGESGSTIDIFNPFKNMEYDGESGIWEDEDTRVFYENLKDLKASLPGILYKDESKNSSSESLNEEKNTKETNKGQDEILDDLEETLDIDEDFEDKDNEDSSDESTPEGGTVITSSTAALEALILKLPTCVNKDMIDEIAMDFMLSCNTKKNRKKLCRSLFNVQRTRLDLLPMYSRLVATLDQCVNDITPELVRLLKGEFKHHLKKKDQINLESKIKTVRFIGEMTKFKIFPVADTLFFLKLLLEDFTHHYIEMACNLLEVCGRFLYRSPDTHIRTKNFLELMMRKKTVQNLDSRYLSLVDNAFYYCNPPDRQKYVMKERPPMHEYIRKLLYMDLSKTTTEKVFRQMRKLPWENTQIALYAIKCLIRIWNVKYNSIHCAANLLAGLAIYHEEVGLFVVDGILEEIRLGMELNHPKLNQRRLCCVKYLGEMFNYRLVEANVIFNTLYSFITFGNTEDGSPSELDSATHLFRIRMVCTLLDTCGEYFDHGSSKRKLDYFLVYFQLYILRKRANPEWNEYHPFPRDLDYMVADTLELLRPKLRPLSTLEEAMEKVEQIQKDHQEQLEKVLVSDNQETESDNPDSLRTNPIAVPGVAKVASTSNSLSNSPCQSPRLREEYEPSESGESEQDVEERDNMEEGDDLDEYEVIEMDDDDDDDDDDDNMSKVKVLSPPKSEPTAEDLDFENKFERLMIDDLQYRRGESLKVPNLDIAVPMHLKGQGRKSAPSPKEDESVNFVLMLRKGNKQQFKDFEVPISSNLASTVRQKQVAEQAEQEELKRLVLDYNQRQEEETYNEIMSQQRQGSDFVGRGQYHRQKKRPPPPYNGSTDTAGGMFPNMTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEQ5</accession>
    <name>A0A6P8HEQ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial fission regulator 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551112.1">
        <property type="nucleotide sequence ID" value="XM_031695252.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HEQ5">
        <property type="interactions" value="886"/>
    </dbReference>
    <dbReference type="GeneID" id="116288460"/>
    <dbReference type="KEGG" id="aten:116288460"/>
    <dbReference type="InParanoid" id="A0A6P8HEQ5"/>
    <dbReference type="OrthoDB" id="2133332at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007972">
        <property type="entry name" value="Mtfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215">
        <property type="entry name" value="PROTEIN OF UNKNOWN FUNCTION DUF729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14215:SF0">
        <property type="entry name" value="WH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05308">
        <property type="entry name" value="Mito_fiss_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551112.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="41751" checksum="67EBDF4762F2040C" modified="2020-12-02" version="1">MMDVFVEVLSFILEQYFGWDEYEISALWRTNPGRRRSIVRQIASSLPSVFPRLYSKRSIIREIASRLPLRSIKRPHFQIGSNDIQNELEYTEGSDEWIMGPEYYDDTFSCIGSDRESSSGFLSLADDDIDDELLSICGDDIPKDTTECIKLSNIDKEPDILMVNNEAMKKISALEEELNRLRAQIAGLVAAPPCTPSLPQIGPMTSTPCTPGAAPPPPPPPPPPPPAVSTPVKSVIDVIKENRSRRKTIAGLPTDKPSNVPXMTDVLKGLGSVKLKSIERSPGGTPVRNKPLESEGNDPSSIIARALKKKFAHRRKLKNDDSPSLDKENMSSFSPSPSRSPKIPQFGPHLLKPAKARRLSGTDFIAKPLHSSPLAEINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HET3</accession>
    <name>A0A6P8HET3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116291239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116291239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554241.1">
        <property type="nucleotide sequence ID" value="XM_031698381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HET3"/>
    <dbReference type="GeneID" id="116291239"/>
    <dbReference type="KEGG" id="aten:116291239"/>
    <dbReference type="InParanoid" id="A0A6P8HET3"/>
    <dbReference type="OrthoDB" id="5975444at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000003">
        <property type="entry name" value="Neuropilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027848122" evidence="6">
        <location>
            <begin position="28"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="304"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031554241.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="46645" checksum="F7BE983B673A26AB" modified="2020-12-02" version="1">MPIQVFATTSILQALACLLIVTGTVVGARKPCKMTQSGCNNSDVIIKCPHFPADQSNLISLYWRVRNRTTRSSKTMAYMTANGKIIYYTKNTVLDGRLTVYPNGSLEVKSLVPEDAETSYEYHVRTKTNPIPQRCIISLQVKCNGEVSNFSQDVCVEDEVVLDCPAKHRTNPRVFKELRWLKETSGMLKLVASLSSTRVRINEEGVLLHGNGSLVLPRGRAIGKDTYKCFVHKIGKGRRREIHEVGLNNSKCHKTGGNVKTTQGRITMTTTAKTIQSTGVVMSNAPTPSVSTEAVSPSVTAMVCGGVLNNSVGTFQSPNFPSTYPANSHCEWTISLPQDYAAINITLNQVNLEGEEKCRHDYIAIYDELHNQIGCRSCGTHNSPLEVQVRGRIAVIVFESDSSVNKSGFLARYKGALNVSNRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHA3</accession>
    <name>A0A6P8HHA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555226.1">
        <property type="nucleotide sequence ID" value="XM_031699366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHA3"/>
    <dbReference type="GeneID" id="116292116"/>
    <dbReference type="KEGG" id="aten:116292116"/>
    <dbReference type="InParanoid" id="A0A6P8HHA3"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555226.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24292" checksum="7FCFFB12A616D58B" modified="2020-12-02" version="1">MLPENDSQNLHGKQRETSRIFYIGVKCFDVSVYSIRGHSSSPGLSVFSVFLKSGLKTFKTTESKKMAFKLTEAQINEYTKAFNDFDQDGDGHLSCEELGVIMRSIGHNPSPKELQEMMTVADRDASGTIDLLEFLEIMAKKSEEDSSEQDLKEAFSLFDKNGNGVISADELKFVLSGMGCELSDDAAEEMIKQADIDGDGGINFEEFLRLLKDRNEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHB5</accession>
    <name>A0A6P8HHB5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">50 kDa hatching enzyme-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116289243</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551992.1">
        <property type="nucleotide sequence ID" value="XM_031696132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHB5"/>
    <dbReference type="FunCoup" id="A0A6P8HHB5">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="GeneID" id="116289243"/>
    <dbReference type="KEGG" id="aten:116289243"/>
    <dbReference type="InParanoid" id="A0A6P8HHB5"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027760683" evidence="14">
        <location>
            <begin position="19"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="15">
        <location>
            <begin position="94"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="147"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
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        <location>
            <position position="171"/>
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            <name>Ca(2+)</name>
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            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="172"/>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
    </feature>
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        <location>
            <position position="179"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="189"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="191"/>
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            <name>Ca(2+)</name>
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        </ligand>
    </feature>
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        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="194"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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    </feature>
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        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="216"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
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        <location>
            <position position="222"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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        </ligand>
    </feature>
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        <location>
            <position position="230"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031551992.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="35138" checksum="076CAAAE67763403" modified="2020-12-02" version="1">MKLLVVFALCAVSAVVFAEDEETFALKYLNQYQYISQSRSGNQNVETALKNFQKFAGIPETGRVDAATITQMKKPRCGLPDMDESGLRVRRYKTAEPWGKKELYYFIQYGRDLPTRTQDNVFYYALKYWADVSGLSFRQVGRAEHADIKISFGSKTHQGTNAESTCGYPFDGQGKVLAHAFFPSDGRAHFDEDEKFTHETSEGTNLKWVATHEFGHALGLHHTDVKGAIMYPYYTGYVKNMKLHSDDIRGIQSLYGEYKWWVVWGELWVVWGDVWVIWGYVWCNVWVVWGDEWVVWGDDGGCMGGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHD0</accession>
    <name>A0A6P8HHD0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Zinc finger MYND domain-containing protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC116291324</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="26">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554353.1">
        <property type="nucleotide sequence ID" value="XM_031698493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHD0"/>
    <dbReference type="FunCoup" id="A0A6P8HHD0">
        <property type="interactions" value="1868"/>
    </dbReference>
    <dbReference type="GeneID" id="116291324"/>
    <dbReference type="KEGG" id="aten:116291324"/>
    <dbReference type="InParanoid" id="A0A6P8HHD0"/>
    <dbReference type="OrthoDB" id="6272564at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140006">
        <property type="term" value="F:histone H3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20159">
        <property type="entry name" value="PWWP_BS69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000002">
        <property type="entry name" value="Protein kinase C-binding protein 1 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057053">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047268">
        <property type="entry name" value="PWWP_BS69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
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    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047269">
        <property type="entry name" value="ZMY11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24324">
        <property type="entry name" value="MYND_ZMYND11_ZMYD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="24">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="20">
        <location>
            <begin position="172"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="22">
        <location>
            <begin position="284"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="23">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="515"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_031554353.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="74471" checksum="F7EE5FADAA3B8042" modified="2020-12-02" version="1">MAKFITRRYSDPAFVKALREGILKIASQKQCPNEDRIVRALQNEYEWTKADILKQLKLAVKDGFLHQVTAISSHGSTKGIPQTAYRVRSNELDETLRNKESHDWYCWMCHNPGEVILCDYCPRVFHRRCAHDGTVSGGKWKCSSCQPQKLPPLMNSKTPEELAKMLIFTMDRMKEKAKDFLKPIDTEEYEDYLEYIFKPLDLSLLEKRVTQKCFKTPKEFREEAQWMLHNSIIYFGEDADMTDLAEAIMEDCDGELEEMVRCPDCYLMSNIRTNNWFTKPCYFPHELVWAKMTGEPPWPAKLLSWDEDKSKALVRFFGTAHQRAWVASKNITPITQKPEVKKRPQRWMQAIDEMKLYQRQLNQLENNMNTVKKTPLNQSQVDEKSTQTDEKETHPDKRRKLDSELELNKVTEVRKELEKQAKENAEIIRKKDERICILQDHAKTLEEHLSSAVMNLEGERNRAKQLKQKLEMMEKEISRNKNIIEMPNHVILNGSASRERELEVNDKMVAPSDSQKDLEREIKEAVKRAVNKERLEKERAIEDAVKRTKREKEKQIEKSLQVVRNEAEKSLQEAIQLTKRKQWCAYCSKEAFYPCCWNTSYCTVDCQKAHWCSHRFQCMRLACNCGTRECVKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIM6</accession>
    <name>A0A6P8HIM6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116289628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116289628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552435.1">
        <property type="nucleotide sequence ID" value="XM_031696575.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552436.1">
        <property type="nucleotide sequence ID" value="XM_031696576.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289628"/>
    <dbReference type="KEGG" id="aten:116289628"/>
    <dbReference type="OrthoDB" id="5956474at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14389:SF3">
        <property type="entry name" value="PROTEIN FAM111A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14389">
        <property type="entry name" value="SI:CH1073-475A24.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552436.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="70253" checksum="E2C3EB780817E72E" modified="2020-12-02" version="1">MAHSSGNHSDXDVIPGEKMKLEKDDSWPSSSAQEKSIRSSQKLLFKVKFSGKTKDCQTNGQETIKDMLIRYHPKLPKERAFKNMIFKRIRNDCAINLGLPTGALSDEEYECVIRTKSDGGESDFANMRQYNVKNYRKDWDMGCFFIKFDKKRNFQPSVGDIRTEVDMVQIDFFQEESLYGAIVRDKRLQIKNDKGQLVVAKWYFKLDDSEVSLSNDAKLYKENSFKLYQKRQADTKLPESVPELLEPNLAGAKIYCLKENDTVKPESNSNASLVAMSTNFDIQASSSGSNSQGIKFTCDTDFEDFLKRHFNVEVQKQAEQKIEKKRISSIKRFFSQHYNNFALTKGNVRSASKWKDLTMIFDSVGAVVVELDSGKEFSIGTCFVIGSEYVITNRHVFDMTLNHVGFKDFYVDFEYKHGCHGYKFRFSKTPVISSDADFANDYAILQLRESDKELPPSLAKCGYVIPSIDDNINAGTWLTLVGYPQGADGKVVEDACPIENPSSLHKDVVLSLSLYDHTTLKDLKRRTYHTGAFFHGSSGSPGVLMNEKLLVVLHCRGFFLQDNEGSIIEQGVKMTAIKNDVDIKIKYGILKGFTLNELFDIPLNPKEEPMAIDLDAGQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ61</accession>
    <name>A0A6P8HJ61_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031555886.1">
        <property type="nucleotide sequence ID" value="XM_031700026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJ61"/>
    <dbReference type="FunCoup" id="A0A6P8HJ61">
        <property type="interactions" value="1280"/>
    </dbReference>
    <dbReference type="GeneID" id="116292671"/>
    <dbReference type="KEGG" id="aten:116292671"/>
    <dbReference type="InParanoid" id="A0A6P8HJ61"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000046">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF14">
        <property type="entry name" value="FI05488P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="125"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555886.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="92575" checksum="F7D0DC1EED31D1CD" modified="2020-12-02" version="1">MSFKTRAASLGELNGGQGASDVAQDLERCKSARSLEKKKSFRFRSKHKDENKKLSRTSSVRSLTNFIQRFAGKVSVQLPRKASSFSTVASGEVFVEASSYKKRDEEVENKTDNPCDKIPEVLSLTGIKNHGNTCFMNAIIQCLAHTDLLAEYFVLGNYKQDMKLRKGQNKKFGTRGEVTEKLATLLRNLWCSQYNSQLSSDFKAVVGKHGVQYRGYAQHDAQEFFLWLLDKVHEDLNRATKKKYKPNKDNIGRSDECIASESLSNHMRCNDSIVLDLFQAQHRSSLACPQCDQQSTTFDPFLCLSLPIPQRETRPIYVTVVFVGSSRAPLRIGVSVPVYSKIADLSKAVSEMTEIPTDRLVMTELSYDGFHRSFQDHQSISIIHEGDNIYAFEAPKQLYPDPESLGEKTLTVPDDDGGTIQESLIILVTNCIGQGKNIRRFGPPFVFHTLREVSFAQLQSIFLHGMKRILQDNVKKQANKQNPLFALRIMNGLQGKCYLSHEVDHPLYQATVDTALKHGEDNSAPQHIRMVIEWEPETKERCVKSDINGHPEEHSSVREMEAEYENSHTVSLNDCFSLYTKDEKLGEEDAWLCPKCKKHQQGTVKRLSLWSLPEVLVVHLKRFRQISSGRTKLHTMVEFPVSDLDMTSHLEPRRKSTTETLPAWPSWRRNRRSSSSGNEDNLYDLYAVCNHMGTMSGGHYTAYCKNPTDGQWYLYDDTRVDKLPAAKVNSNAAYLLFYARRIVGSSSASESSGSSDHWTRKIPQVLSESLASSREELDKEESPPSNEKLTSSTDALNTTKNEEKERSKENLVLTESCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJU6</accession>
    <name>A0A6P8HJU6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 5">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 5"/>
    <dbReference type="RefSeq" id="XP_031552865.1">
        <property type="nucleotide sequence ID" value="XM_031697005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJU6"/>
    <dbReference type="FunCoup" id="A0A6P8HJU6">
        <property type="interactions" value="707"/>
    </dbReference>
    <dbReference type="GeneID" id="116290033"/>
    <dbReference type="KEGG" id="aten:116290033"/>
    <dbReference type="InParanoid" id="A0A6P8HJU6"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552865.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22562" checksum="560571484A73FBBA" modified="2020-12-02" version="1">MKAVIQRVTQASVSVDGEIISSIGRGLCVLLGISRNDTPKEMEYIVRKILNLRLFDDNGQRWKKSVMDKQYEVLCVSQFTLCSVLKGNKPDFHCAMGGEESEKFYQTFLEKMRTAYKPEAIKDGKFAAYMQVHIQNDGPVTINLESTPSSNNQQEKQNPGKKVKSSSEENGERENSVQEQTASNLTEQVKGLKLENMDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM01</accession>
    <name>A0A6P8HM01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290703</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553665.1">
        <property type="nucleotide sequence ID" value="XM_031697805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290703"/>
    <dbReference type="KEGG" id="aten:116290703"/>
    <dbReference type="InParanoid" id="A0A6P8HM01"/>
    <dbReference type="OrthoDB" id="5978963at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553665.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26155" checksum="3C8E1093DBFECD15" modified="2020-12-02" version="1">MDNTEDVENMSDLYHNEESMIAYDNRCGYNTLKEEGPTAQKSQCYEDGFYSFPEASTYIQNFLHEDNMSYSSTPDDLEATSAVFQQFDTILRQQVHTEIEVFRENINRILTNQQYQFKQAFDLPDPTINTTEAMHEVPQSSYAEEANSDESQLMPDKTQSDGDENAIGRLRWYXLENYPSEESFTSQEIQEAVQNDEEKLTMDFLVRMLTADSAITAALRRKEYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMB3</accession>
    <name>A0A6P8HMB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Placenta-specific gene 8 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553782.1">
        <property type="nucleotide sequence ID" value="XM_031697922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMB3"/>
    <dbReference type="FunCoup" id="A0A6P8HMB3">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116290812"/>
    <dbReference type="KEGG" id="aten:116290812"/>
    <dbReference type="InParanoid" id="A0A6P8HMB3"/>
    <dbReference type="OrthoDB" id="5989075at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553782.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22983" checksum="9AAC653834259D37" modified="2020-12-02" version="1">MSEPQTTITEEPKSQAPPDYQQSSPEQYPIQAPPMMQQGQPMMQQGQPMMQQGQPIMTQPGQPMMQQGQPMMMQQGQMAPMHSQTTSNTNVVMINQQPVTARAAPREWSTGLCGCFDDCGTCWYSVFCHKNVLCEISQRLGEGRCFVCCCPFPLLSLRIKFRAQQNIKGSLCNDHLTVQYCYLCALCQLAREIDHVQRIQRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMX1</accession>
    <name>A0A6P8HMX1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116291022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554005.1">
        <property type="nucleotide sequence ID" value="XM_031698145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMX1"/>
    <dbReference type="GeneID" id="116291022"/>
    <dbReference type="KEGG" id="aten:116291022"/>
    <dbReference type="InParanoid" id="A0A6P8HMX1"/>
    <dbReference type="OrthoDB" id="10275258at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028088923" evidence="1">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="49"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554005.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18149" checksum="F91FB08501D48AC1" modified="2020-12-02" version="1">MIFVLLALFVASAVSLDLNREGCGSLLKGATFSATSGNAGFPSLCNKPWIPKSLDNDQKLTVDLGEAASISRVLFAGDPTKPDTTNQIKLFYSNDGNTWDCISNGSPSPCRPFYSNRPPPVKGSDVNEVDLPTVIKARYFRFQPLEPSPKYRDGSSSLRVDLIGCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN61</accession>
    <name>A0A6P8HN61_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116293168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031556423.1">
        <property type="nucleotide sequence ID" value="XM_031700563.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293168"/>
    <dbReference type="KEGG" id="aten:116293168"/>
    <dbReference type="InParanoid" id="A0A6P8HN61"/>
    <dbReference type="OrthoDB" id="5988994at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556423.1"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130292" checksum="A7A62A578B605951" modified="2020-12-02" version="1">MASNDSLNHTVSEVYLSWVNSCIHDSSSKISNLKESLKDGCVFCQLIEKTTGCDSLFASKEQESSSNNXKYHSTIDQAINYMQERGIEITESDTYIKDIASGDLKAILDLLWLIILNFDIHSHNRAAYQRSVSMGKRFLLEWFARELPDVNLEPKGNFVECFQNGVLLSRLISKYCSVTNTADSQIKSPDNNVLKGLLEAADSQLGVPSCILSPLRLLNGTIDEYTLLIYLAILRRKVCEKKGEDCYKGGGSPIKQRTPQTTPAKSPLHVLQTPPRPVNGHQESPLSPTTLKNLVEQQTKSHEAIQALQAKLQAVNYQPLTPKPNKHPLPRAGNQEMPPVFGLSCQSKVMSSDDTSRRIDCNENELNSSVVNSGKSDDNIKSIYGTVDKHILESMLDTVQGYMLQSGPQNKSWLNGEEAKATDSLTEKQDSNSSPSVSSKTEESSETSMPVQVNGSDVAQLEKQETKDKYKASESMENGHEVDVIDSEVDEAKPSHADKRLNSLAGGEVQQESTKEIANQSTPKSEKQVTFSGLDAVFALPKDSSSPNELSRTEFPCTTGCAAEVVDDMGNVLDLVEIKKAGFDYPISSKETVTWASCGEGLNDNDEANESTGSISFDDENDQFMMYLNSIEQTALKFKLQVEQAKIDTLQILKRRLEQAYEGTPLEEIPAKVHEKLQETIAQIATEEVKKYESVLHVDAQDEFDDDECGILKQMRAELDALAAENFTLSQELEACKRYEQEYHTLQGKIEGMEDGLTTMKHDYATKNGESEFLGKRIEVLEQEMVSMRVEYEEQIRELQNENLELQKECLELDDENRTLEDELKKIQVSLTEKTYEADIYESRLDDNLAEKITAAELEALEIRVNELERHNKAMKASSEADHAVVICLEKKVEDLESSLLEAKTANSNLLTELHESQRQQATDRAKLSSYKDELEALRRENKVLKCSLESSENEVQYQRRKNEQSRTPVTKTRSPGSLGNKREIWNEIRELETILKDVQKEKKTIERKYQAFRKDSCDPNASTNSSNASILENSQSTNPGSPNSTLRRTPDTTPRSRKTTSLLDRVNNLLDKSSLPNGTRTDGITSTHANRVSATLSRDAGSSPSNEVLTSRSSASLGRTPVNNGLSEELMSLRKHVGSLEAEKASIIRELNTIRTPTKDENSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQR9</accession>
    <name>A0A6P8HQR9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 33A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557453.1">
        <property type="nucleotide sequence ID" value="XM_031701593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQR9"/>
    <dbReference type="FunCoup" id="A0A6P8HQR9">
        <property type="interactions" value="2258"/>
    </dbReference>
    <dbReference type="GeneID" id="116294063"/>
    <dbReference type="KEGG" id="aten:116294063"/>
    <dbReference type="InParanoid" id="A0A6P8HQR9"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1910:FF:000005">
        <property type="entry name" value="vacuolar protein sorting-associated protein 33A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557453.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="70671" checksum="0937DFD556B8CC0A" modified="2020-12-02" version="1">MRIRSKMATTQSNLTNGRINVGLLRECSRRELLECLDKHPGSKALVWDDKLTGPFGLIAEYQLLKEHEVDKMFPLRPGKLPPSQVVNIIFITRPVPSQMDIIADNILKEEDKGIKKDFHIMFVPRKTILCERRLQERGVLYANIEEYPLDLIPLDNDLLSLEMDSCFKECYIDNDFTSLYYVANSLMGLQLLYGTIPKIYSKGEMAKRVLDMVMRKKREMADTENQLPPQIDTVLLLDRAVDLLTPLFTQLTYEGLIDEFYNIQNTTAKFPPENFPKPEEKGPSTSQQPPGPKKVVLNSGDELFSDIRDSNFSAVGLQLSRRAKQISAAFEEHKTAKTVGEMKQYVQRLPYMQKAKASLAIHMSIAELLKEKTDDEEFREDIRLEQEFAQGLDTDKINPYIEKYIALKKPLNKVLRLMCIQCLTNNGFKPKMLEYYFREIIQTYGFDHLYRTLTPLQTAGLLRQQGARTYTAMRKSIKLFVEDVREQNPDDIAYVYSGYAPLSVRLAQFLSRPQGWRGLEEVLRLLPGPTIEERQPLPPGLQKRSSAPADSNVGSPPKVTLVYFIGGCTYAEVAALRFLSQLDNSPTDFIIATTKMINGSSWIESMMEDTVPLESNPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRE3</accession>
    <name>A0A6P8HRE3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 20">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="20">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116295303</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.</text>
            <dbReference type="EC" id="3.4.15.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="20">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 19 20">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="20"/>
    <dbReference type="RefSeq" id="XP_031558944.1">
        <property type="nucleotide sequence ID" value="XM_031703084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRE3"/>
    <dbReference type="FunCoup" id="A0A6P8HRE3">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="GeneID" id="116295303"/>
    <dbReference type="KEGG" id="aten:116295303"/>
    <dbReference type="InParanoid" id="A0A6P8HRE3"/>
    <dbReference type="OrthoDB" id="10029630at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000004">
        <property type="entry name" value="Angiotensin-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 20" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 20" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16 20" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028035955" description="Angiotensin-converting enzyme" evidence="21">
        <location>
            <begin position="20"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="13">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="14">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="13">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="14">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031558944.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="79738" checksum="651D0B0629A3AEBC" modified="2020-12-02" version="1">MAGLNLFFWRSWSLLLILAEELMIGRSRLKDIEIRGSKTIIEESEALWNYYTDLTPKKEEVSIKASTRAKEFYLEASKNASAMLSKHVDLSHDVARQMRLIRRNAMPNLQKDVEAIEKLQANLTAIFSNGRVCKNSTDSSNFCMPLFPDLNNLMAKSRDYDELVWAWRGWRDAVGPPMRAQYKELVDMLNRGASEHNWGDYGHFVRSEYEMGNDLIPVLNGLWTAVKPLYQELHAYVRYQLKKHYKKMSPDGPIGAHLLGNMWAQDWSAIYDLVQPFPDVAPLHVTPNLIKQHYTPKKMFELAQSFFVSIGLDAMPASFWDKSVLSKPENKSMVCHASAWDFCQGDVRIKMCTSVNQDDLITVHHEMGHVEYYLAYKDLPYAYRTGANPGFHEAIGDTITLSVETPKHLKSIGLLYSLNTSDEATINFLMLQALRRVASLPFTYLVDKWRWKVFAGNIRPSEYNAEWWKLRTYYQGIVAPVPRSENDFDPGAKFHIGSNSQYICYFVSLILQFQFHQSLCRLAKHEGPLHECSIYKSKEAGQKFREMLEAGSSQPWPQTLHHLTGEREMSANAILEYFDPLKKWLFTYRQAHKYPLGWGKLKKQGTANGVRKTINNSSLKPKADSLAANPKGVSFTKAKNSNDGLNLPDLKTALEELQPGNSKTTVNKNESLLEAKSSIVKARPMFLPNKVKDQLNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRL8</accession>
    <name>A0A6P8HRL8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116292166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031555290.1">
        <property type="nucleotide sequence ID" value="XM_031699430.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HRL8">
        <property type="interactions" value="3701"/>
    </dbReference>
    <dbReference type="GeneID" id="116292166"/>
    <dbReference type="KEGG" id="aten:116292166"/>
    <dbReference type="InParanoid" id="A0A6P8HRL8"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046426">
        <property type="term" value="P:negative regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14545">
        <property type="entry name" value="PTPc-N1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051985">
        <property type="entry name" value="NR_tyrosine_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46047:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="191"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031555290.1"/>
        </source>
    </evidence>
    <sequence length="715" mass="82325" checksum="F22CA96A6EEB9AC2" modified="2020-12-02" version="1">MLSELYELDASNGWVPHFQKINWMAKENASPQKIAKAXENRLFNRYRDVLPYDHSRVVLKEGETDYINANLVEVPSVNERYILTQGPLKNTSLHFWQMVWEQNSQAIIMLNRVIEKNQIKCHQYWPCGEKVGHTNVLEFGCFRITYIEETMSEFFTVRTLEIFNMKEEEKRXIFHFHYLHWPDFGVPSSPASFLSFLFEVRNAGVLSSDVGPSIIHCSAGIGRSGTFIMVDSILKEVEQTRDLNAIDVKTAVLKIRRYRVGLIQTPDQLRFTYAAILEGTRLLMPQLYEEALEKFSNERAHEEEEEEVSEEDEVPPTVPVRKRQELDQTVDKEANIAAKRKRSLPDIPTESTSAAAETPKETSAAATADISKGVPSYQGFQADNISSDESDGEDEIIDLSESSTSSSSLAGEESEEDRERLYSKEDLTHEQDDQRYSKASGEXDQEDEEGSIETEVSHKTEEEXIKMEENEELQAEVEVQEDFTKIKPEVSQEGKTFPIEKEYKITPETTIPRKEMDSWMVEREEMQGKIEDKKEFATKTEETANTEKMNAFKIQNRAVSKPLPEPMESGSDIRESGHGAYARITKAEKIIRPRDEPSNESIGGSIGTNPRKSDPKIQSKKLESDTKSPDDNLQPSTSKESMTEVRRRQRQEKKEKTEKLVKDIKARVEYEENTRWIRKIIRNSLIVIGICATAYIAYRCYRYFSHIPRRKPRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS72</accession>
    <name>A0A6P8HS72_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized skeletal organic matrix protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555505.1">
        <property type="nucleotide sequence ID" value="XM_031699645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HS72"/>
    <dbReference type="GeneID" id="116292348"/>
    <dbReference type="KEGG" id="aten:116292348"/>
    <dbReference type="InParanoid" id="A0A6P8HS72"/>
    <dbReference type="OrthoDB" id="5945635at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028455116" evidence="1">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555505.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34157" checksum="45C878877C655143" modified="2020-12-02" version="1">MDVIFLISLFYLIHRVLSNGCKDMDFKITIEGQALVNHTFLTTQATNDGHCESKCFMDDLCISYNFGRSTSGQSNTCELNEADHKQFPNDLVPRPGTMYRNAENTCDCSTNEVCRMDFIQKTHFCFAAKNCKSFKVVRADYFLDGSGQGQTGLCRGVFKSPSGNTPAEPYRITVEMYTYLVTASSSGAMHPGIGFNVKDEDNFNFVYFRTHVTASCSGYVTQPGRLQANSVKIMNGACSYYVPPANAWFKVEIKVYPGQVKVFIDDNYATTYSGMSTTLIKRGALMVFNGYGNAVKFRNYRIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT22</accession>
    <name>A0A6P8HT22_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Salivary glue protein Sgs-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555830.1">
        <property type="nucleotide sequence ID" value="XM_031699970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT22"/>
    <dbReference type="GeneID" id="116292623"/>
    <dbReference type="KEGG" id="aten:116292623"/>
    <dbReference type="InParanoid" id="A0A6P8HT22"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35383">
        <property type="entry name" value="MUCIN 12EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35383:SF1">
        <property type="entry name" value="MUCIN 12EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555830.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="15660" checksum="F1638DC529B6F9BF" modified="2020-12-02" version="1">MQAPTTADQTTQAPTTADATTQLPTTADTTTQAPTTSDQTTQAPTTSDQTTLVPTTADATTQLPTTADPTTQAPTTSDQTTQAPTTADPTTPAPTTQAPTTSDQTTQAPTTAAPTTQAPTTADPTTLAPTTADPTTADPTTADPTTADPTTQAPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTF0</accession>
    <name>A0A6P8HTF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Testis-specific serine/threonine-protein kinase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116295858</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559674.1">
        <property type="nucleotide sequence ID" value="XM_031703814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTF0"/>
    <dbReference type="FunCoup" id="A0A6P8HTF0">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="GeneID" id="116295858"/>
    <dbReference type="KEGG" id="aten:116295858"/>
    <dbReference type="InParanoid" id="A0A6P8HTF0"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14080">
        <property type="entry name" value="STKc_TSSK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000658">
        <property type="entry name" value="Protein CBG12184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031559674.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35285" checksum="0B6814E0C415AC4C" modified="2020-12-02" version="1">MRAVKRLFTRMMSKLSDDARILNERGYHLLSDSNLGEGTYAKVKCAYSNDTKQHVAVKIIDRKRAPKDFINKFLPREMVVIQTLRHKNIIEVLQVFEVGEKVYVVMELAEKGDLLEYIKKNGCVREWKAKKLFKQLLEAVKFCHKQGVVHRDLKCENVLLDKCHNVKLTDFGFSKFNPQNELCKTFCGSAAYAALEILQGIEYNGEKADIWSLGVILYTMVTGRMPFDDTNMSTLKKQIKNGVEFIKPKQYISDECKDLIQKMMATDHQFRISIPEIESHKWVAGASTPGSRMQSSKSRIQSSQSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVT3</accession>
    <name>A0A6P8HVT3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560519.1">
        <property type="nucleotide sequence ID" value="XM_031704659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVT3"/>
    <dbReference type="GeneID" id="116296612"/>
    <dbReference type="KEGG" id="aten:116296612"/>
    <dbReference type="InParanoid" id="A0A6P8HVT3"/>
    <dbReference type="OrthoDB" id="5970827at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="88"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560519.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23988" checksum="67103C360E00BAC6" modified="2020-12-02" version="1">MLEGISSMFSYIRYRFFSIGYKKRIVIQILLLLFIAFVGVMLRPYFFANLAELDLFGESGTRGNFTVGWDKWTGQMEKLGYRSIGDVYDQCEPESPRVKIGKVLIHFDKKLGTVIATIATNFTMPVSLSKGTVHITAQYHGRTLFDQKYDLCKAKVDTFKCPMKKGQKMRIYETFKLPKYIPKGHYTSYAKGSNDDEICFIMAESNLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW68</accession>
    <name>A0A6P8HW68_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab-25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295802</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts (GTP-bound form) with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer. Interacts with VPS33B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Pseudopodium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559598.1">
        <property type="nucleotide sequence ID" value="XM_031703738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW68"/>
    <dbReference type="GeneID" id="116295802"/>
    <dbReference type="KEGG" id="aten:116295802"/>
    <dbReference type="InParanoid" id="A0A6P8HW68"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031260">
        <property type="term" value="C:pseudopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559598.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24719" checksum="A7F22268BBEE76AE" modified="2020-12-02" version="1">MAGGRYDHYDYLYKIVLIGDSGVGKSSLLSRFTRNEFDLESKSTIGVEFATRSITVDGKVIKAQVWDTAGQERYRAITSAYYRGAVGAVLVYDLTKQKTFQDVERWLMEVREHADQSIVVMLVGNKCDLKHLRAIVTEDAKKYAEENSLSFIEASALDATNVEEAFQQTISKVHHVQLAKMKKELDQRGPEDKGTANRSAQNNQINLDQNSSSKNCCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HW74</accession>
    <name>A0A6P8HW74_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHD finger protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116296729</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAYP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560659.1">
        <property type="nucleotide sequence ID" value="XM_031704799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HW74"/>
    <dbReference type="FunCoup" id="A0A6P8HW74">
        <property type="interactions" value="966"/>
    </dbReference>
    <dbReference type="GeneID" id="116296729"/>
    <dbReference type="KEGG" id="aten:116296729"/>
    <dbReference type="InParanoid" id="A0A6P8HW74"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071564">
        <property type="term" value="C:npBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15528">
        <property type="entry name" value="PHD1_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15529">
        <property type="entry name" value="PHD2_PHF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000202">
        <property type="entry name" value="PHD finger protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038045">
        <property type="entry name" value="PHF10_PHD_finger_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="511"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="608"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031560659.1"/>
        </source>
    </evidence>
    <sequence length="688" mass="78703" checksum="CCCA9718800E4F85" modified="2020-12-02" version="1">MPRKKRGPKPKGEVEKSKDKDNESGENEQEKAKASNPVTNDKPDKEEPVKIPFPIKRPRGRPSKKWQEQLALAIAEGRAVPFEKKPKKKKDAVKEKKEKGAKKDKKENKAPKTPKKDKKEKEEIPETKPQTPSPQAAKTTEKEPASSQEPVETVQPTPKKKPSISYLEILQAVLDKLYEYRWPQDDTGEYYLLEQQLSDFLGVSIQAKHQDLEFHTLEEEEKNFLKEKKIISDGQQNIDLLAVKTDDATLLVNEHYPNKYQDFLQLAHKREKYNLLKKIEDEKTVKESKKIPNPLKRALKDAVEFNAQLALQRREERCSYFDMQTQIIHYPVNKTSKLPNHMTVPSKYPVALLPGQFQEFYKSYSPSMLRSFPLGTVIDSSRHNQMFDSRSSLTGGSSDSSGGSSSSSSSGDDDSDDDDSSDSKASDDEEMNEEEEEEVSEPPAKRRALGYKPPHRPDALCGICLKGSESNKKGFMEELIHCSQCENSGHPSCLDMSPQLVKVIITYPWQCMECKTCTQCRDPFDEDKMLFCDECDRGYHSFCVGLKQIPVGRWTCELCGVCASCLRRTPGEGPNSRWKSEYTKPRDKSEPQFLQTLCSPCSRLFRSGNFCPVCLKVYRNDESDLPMVCCDECDRWVHTDCDDIDDKSYAELSKEKTKYRCILCRGEKEERMDSFARKNRDHEVSQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWI6</accession>
    <name>A0A6P8HWI6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear receptor-binding protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">MLF1-adaptor molecule</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116295910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559721.1">
        <property type="nucleotide sequence ID" value="XM_031703861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWI6"/>
    <dbReference type="FunCoup" id="A0A6P8HWI6">
        <property type="interactions" value="3362"/>
    </dbReference>
    <dbReference type="GeneID" id="116295910"/>
    <dbReference type="KEGG" id="aten:116295910"/>
    <dbReference type="InParanoid" id="A0A6P8HWI6"/>
    <dbReference type="OrthoDB" id="1034557at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000842">
        <property type="entry name" value="Nuclear receptor-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000098">
        <property type="entry name" value="Nuclear receptor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559721.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57799" checksum="37C323C8B7B395E3" modified="2020-12-02" version="1">MASGLVIADTNVNSEHSGDESEDDDDVVEQSPCGRWEKRRQEVMQRDVPGIDHAYLAMDTEEGVEVVWNEVQFSERKDFKSQENEIGVLGWMVPNSDEETIKKVFENLIQLDHPNIVSFHMFWTDVQPDKARVIFITEYMTSGSLKQFLKKTRKNDYKTLNEKVWKRWCLQILSALSYLHNCDIPIVHGNLSCDTIFIQHNGLIKIGSVAPDTIHNHVKTCREERRNMHFIAPEYGKPGHVVDCAVDVYAFGMCALEMAALELHDIEGPVSKEAIEKAIQGLESPLQKDFINRCLAEDPAERPNVLHLLLDPCLFEVHSLKLLAGYCMVDNDVATPDNRENADHEKVVATYKARDGTIKEFKQENSPALEIEKFLEEVRNGLYPLTGVEKKKKNLTPRQRPKSPDSVQAEQKKNETETYDEESRRYTNMNCEMKALESGDGKQLVLSLKFGDRMKRVLTCDVKQGEDASGLANELVQFGFINHMDRDLIAADLENKLAASRNVESQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWS9</accession>
    <name>A0A6P8HWS9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Dr1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Down-regulator of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Negative cofactor 2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NC2 beta/DR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557042.1">
        <property type="nucleotide sequence ID" value="XM_031701182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWS9"/>
    <dbReference type="FunCoup" id="A0A6P8HWS9">
        <property type="interactions" value="2085"/>
    </dbReference>
    <dbReference type="GeneID" id="116293716"/>
    <dbReference type="KEGG" id="aten:116293716"/>
    <dbReference type="InParanoid" id="A0A6P8HWS9"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557042.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20297" checksum="A25C973B5C582761" modified="2020-12-02" version="1">MADGVDDDVTLPRAAVNKMIKELIPNMRVSNDARELILDCCTEFIHLVSSEANDVCGRQTKKTISPDHVLLALEALGFQSYIEEVKSVLADCKTQAANKRRASTKLEHLGIPEEELLRQQQELFQQARMQQAQAEQEELMQLQQAQALALHQQQQQQQQQNLTASQQNKSVSNPPPTGQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX14</accession>
    <name>A0A6P8HX14_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Neuropeptide FF receptor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18" type="primary">LOC116293868</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16 17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557223.1">
        <property type="nucleotide sequence ID" value="XM_031701363.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557224.1">
        <property type="nucleotide sequence ID" value="XM_031701364.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557225.1">
        <property type="nucleotide sequence ID" value="XM_031701365.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557226.1">
        <property type="nucleotide sequence ID" value="XM_031701366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX14"/>
    <dbReference type="GeneID" id="116293868"/>
    <dbReference type="KEGG" id="aten:116293868"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005395">
        <property type="entry name" value="NPFF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01570">
        <property type="entry name" value="NPFFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="39"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031557225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031557226.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36668" checksum="EDD6F49F65AE421E" modified="2020-12-02" version="1">MDGAMVNATAAPPVVLEPLGMRVIRLAIYIIIFLIATIGNSLVIFVVYKTRELHTVTGYLIANLAIADLGVGLLCIPFTVVVFELNFVWPFGYFMCKLISPIQVFFLMGSVGTLMAISIDRHQSIVYPFNPRITITQGKLIIALIWLIALFPAFPMLGVMKQSYTWHKDGQPACMEDWPDQKLNVAYTVASFLLTYAIPLPMIIILYIRIGLKLREAIKDAADRPGFHAAQQTTRIIKMLVAVVVCYALCYLPFHTLYFTVSSGHRTRPDILWLVMSYAQVLLYFNSASNPLLYAFLGDQFRNGFKKALGIKPKRDGAISTSTHGTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXC4</accession>
    <name>A0A6P8HXC4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116293954</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031557315.1">
        <property type="nucleotide sequence ID" value="XM_031701455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXC4"/>
    <dbReference type="FunCoup" id="A0A6P8HXC4">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="GeneID" id="116293954"/>
    <dbReference type="KEGG" id="aten:116293954"/>
    <dbReference type="InParanoid" id="A0A6P8HXC4"/>
    <dbReference type="OrthoDB" id="17010at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.130:FF:000001">
        <property type="entry name" value="Vitamin K epoxide reductase complex subunit 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF8">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028474730" description="vitamin-K-epoxide reductase (warfarin-sensitive)" evidence="13">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031557315.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17723" checksum="EA0B18EC493AF4AE" modified="2020-12-02" version="1">MNVLVCCRVILCLTGIGLSVYALHVELSKTQDDNYKALCDISEHMSCSKVFASKYGTGFGLVEPVLGKDSPLNIPNSIFGIVFYSLVCILGLFKSKFAAMTIFLFSVTSCIGSVYLGYILYFVLHDVCVVCISTYIVNGLLFIINFISLRKASSVKKSKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXS5</accession>
    <name>A0A6P8HXS5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC116294022</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="26">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031557397.1">
        <property type="nucleotide sequence ID" value="XM_031701537.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HXS5">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="GeneID" id="116294022"/>
    <dbReference type="KEGG" id="aten:116294022"/>
    <dbReference type="InParanoid" id="A0A6P8HXS5"/>
    <dbReference type="OrthoDB" id="5919042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20814">
        <property type="entry name" value="CRIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05601">
        <property type="entry name" value="STKc_CRIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000081">
        <property type="entry name" value="Citron rho-interacting serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000017">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
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    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037708">
        <property type="entry name" value="CRIK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="80"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="24">
        <location>
            <begin position="343"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="1325"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="20">
        <location>
            <begin position="1406"/>
            <end position="1522"/>
        </location>
    </feature>
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        <location>
            <begin position="1549"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1284"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1898"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="458"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="698"/>
            <end position="780"/>
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    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="807"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1227"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1284"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_031557397.1"/>
        </source>
    </evidence>
    <sequence length="1948" mass="222214" checksum="FDC8865A2F20C04C" modified="2020-12-02" version="1">MAESITTRCAKLNQIFLSKNGGRKASSVLSKETLLDAFLVLFDECKSEELFKDKNMSSFVKKYSPTVEELRKLCLNKDDFDVINTIGRGHFGQVQVVKDKHSGDVYAMKTLNKSQTLAQESVAFYEEEREIMATANNPWITALQYAFQDXHCLYFVMEYQPGGDLLSLLNKYDDIFEEDMARFYLAEIVMAIHSLHVLGFVHRDVKPDNVLIDRTGHIKLADFGSSARLSADRMVYSKMPVGTPEYIAPEVLTSMDGSGGPYGVECDWWSLGVVAYEMLCGQTPFEADSVVITYSKIMNYKSSMRFPPDLKISAEAKNLILSLCTGSKDRLGYDGIGCHQFFNGIEWEKLQTTVPPFVPTLEGTDDTSNFDEFEPDSPDPTDHLQKYSQKGFVGKDLPFVGFSFIKHIPSPGSPRRQSSLTLSPANAQQSTSLEKRLNMKAKELKDALNSCHVLTTEKENMIKSLDDLKNTLSEKEKALRIAENERDLMEKEKVLFDSQIKDLQRRLDSERAERNNTDFKTLKLITEIKQNSRKVEEMRDQETKASIEDQQQIISELEQERFIANKRAHRLEEELKTQESVIEESKHRVNDLHSRISKMNEEARRSMEEWQAKLNKVSEDSQCRINELQDKLNKSLNSCQEATDLLENVRRAKIDLEKQLKVMQEEKKKSEKDETDGKKACGEFQNQLNEEGNFRERYKEKAAELRKMSSKVMDLEDKLIKNQREMKKLEREVTSKQTIEEKLQTKEKELTTANRYKRQLESTIKKLQEEQDEKDKAIEARDMKIKVLQARSEEQSINDVGIPATSRPEDLALMEQLKQEKEDIEKELQNQQQRNQSLLDKIRTSEDKIFEAQSEISELQSTNKSLEDAVRKLENEIDEKLLKQEMKAASLLAFDDLELQERAEIALELQHKLQETMKDVEILESQKKELELKLDSLNEQYAKTNVRQEKMEDELKEKQRKLEGQELTISMLKSTCSMLESQVEELEIMNEAYEEKQAKWEATRKNLERSNEKDELVIAEIKRSAEQDKLARSVAEEKLAKSQKDLDELQIAHIKEVDETNEKLKRQRERTDELTQSLGEAEKKHGMVAVELKSVQRKLQLEIKSNNKYKIENERLESQISNLKATNFQINQNIASVMEKFEEVNNQRAALAEQLDVMESSYAEERLKLEATKAQQTKLIDFLQYKTEGQNMKKKKLIGGGGKTWRKQHHDERNVIPKQWKDMQQALEKERASSLKLQTELNRTKAELQTAKMEVAEWKSQCQNATISNRKPVQKVAVLSALQQSPSNQQAPKNTLKNSNPAGKPPLPTEPTVHRPKERMHHNIPHRFVNALNMRPVKCAVCLDTVHFGRQSCKCAECSSVCHNKCAPHLSHTCGLPSQFVEHFSEALSDNKTDSPVKSSSTSSLNGGIENWMKVPSGSVKYGWEKKWVMLRDNKIQLFDKENVKDKTSPIEILHLDGTDGHVTIHSSVMSSELLGTAPTDLPYILRIESRPKCWPVQNLYFMAPSFADKQKWVVALENTLNQIKKAIQSNSDEKLFGNSLLYLENSDKIDINCSQLLSDELLLLGAEEGLFSMSLSKPGHGSHRVIPGIEKVFQIDVIPELNIAIMLTGKERHLCSVDLKQLNSRGKQVNSEVPLTPLTSQTIEKIKNCHLFAMGQYDGSYYVCAATPNKLHLLRFNAGMNAFCTRKEIDTADPCNCIHFADTSVVYGTGKFYSLDLRQYNISEFLDAQDTSLAFAVYGAAQLNIFPIAVLDVTSAGCKDREFLLCYNEFGVFVNSSGXQTRQKTLMWTRLPLAFAYKKPFLFVTHFNSIDVCEIPPSNSPDVHSFTHKFMEIQNPRVLGPAVLPGAVYIVSSLQDSVEMLCFQGSSAATSSCQSDEDFSDFSHLSEMLRSISATSLASEIGSPGRHNDDEKTKTPGNPKKRRSSFLSNGPFRSPSMRKRKCYEVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ45</accession>
    <name>A0A6P8HZ45_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560698.1">
        <property type="nucleotide sequence ID" value="XM_031704838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ45"/>
    <dbReference type="GeneID" id="116296766"/>
    <dbReference type="KEGG" id="aten:116296766"/>
    <dbReference type="InParanoid" id="A0A6P8HZ45"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF5">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028100242" evidence="5">
        <location>
            <begin position="27"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="231"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="408"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="476"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="562"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1100"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560698.1"/>
        </source>
    </evidence>
    <sequence length="1214" mass="134482" checksum="EB7440487C61474D" modified="2020-12-02" version="1">MAPVQVKAVNLLQALFLIILFDELFAEQDQKLRINVLKPEFKSDPEGLLLHRDQANNFRESHGRRRRDLWEECYDEGCSKEEVEEVVSGHALHQYYYGWRCMKLYGSDWTYSGNPSTLQCSNILRDVKVCVNSRTGVGRSQSRNCYFGSAKNVYAVYMENGCNDGKMGNWKLTFNDPSNSVRYVYNVGCRDKENFATVRGATMYSATLVGGGGGDGYISNYKLGWFGYDSKNCGHPGVPANGNLIGNNFYETSQVTYTCRYGYTRVGNERRTCQWHGWDGSLPVCKRLCDPGTYSSRGYEPCTPCRIGTYQPNKRSRSCISCPGGKSTDTTGKRFLSDCHHKCSKAVCNLQAWSQWSDSDSSFENQCASQIRKRFYKKTWQEILDPSGCDSVNKVCPPDQSERRQRVVYCDPLPEPEYGYYLPKNCTITKQACKSVSSSVCMFFCGKGFDRQGTDADFRRVCKADGRWTTSSAKCKDTMAPEITCPENVEVGNERGKSYARVNLPNANATDNSGKTPSIRISTPNIEAMQIFQISETATTVYYSATDDAGLTSNCSFTVKVKDTEKPQVLECPKEHLVYTSERPKRVVFPEPKFQDNYDTAPVITASHKPGALFYWKKYTLTFSARDKAGNTATCSYPLQVGPLTCPLYDPPANGIRSCNIKVNEAKQEYVCVVQCNENYDFDEKPEWSSYACMNGAWNGYKFPIYQQLPEGRPWKDCAVKSSPTGVAKNVKVYAGSCLSGNEETQKKIKEQFLEFINQDPLLSSMFSCLGNNNVDCQLANVKVSKIIDYCLFPSRGLDENAYVIDIKMKVLDLNPDSSSLEKQKLKDIETKMLANKQIVDDAIKRATSMVMKVQVDSVDVEDEDVKGACALGKVVVVKSGSGSELDRSVCVDCSAGTYYSKDAEACVQCKNGTYQDTEGQVYCKVCPGGTSTIGRGAKSLQDCKGICEGGRYSTTGLETCVACSVGKYQPNNHSTSCLPCPAGTSTFDIGTTSIEDCKKLCTAGQFSKHGGLGACLPCPRGTYQPNAKEKSCIKCPSGMTTVGDGSTSKDQCKSSCRMDFENSIDHWTKTGTAFNNQPTYGDNPRFRNRESAQQQGNWWIGGAENRPSPSHPAGQIQGDGPTGTLTSPTFQITGKSLSFLIGGGCDVTKVRVELLIDGLVVKRETGRCFESMERRCWDVSEYQGKVAQVRLVDQSTGSWGHINFDDLRGDSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZG8</accession>
    <name>A0A6P8HZG8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116294577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558065.1">
        <property type="nucleotide sequence ID" value="XM_031702205.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HZG8">
        <property type="interactions" value="2293"/>
    </dbReference>
    <dbReference type="GeneID" id="116294577"/>
    <dbReference type="KEGG" id="aten:116294577"/>
    <dbReference type="InParanoid" id="A0A6P8HZG8"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558065.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19627" checksum="133AA57F75E67A1A" modified="2020-12-02" version="1">MAATLRPYLNAVRSTLTAAMCLENFDSQVVERHNKPEVEVRSCKELLLTPVVISRNEKEKVLIEGSVNSLRVSIAVKQADEIEKILCKKFMRFMMMRAESFFVLRRKPVEGYDISFLITNFHTEEMFXHKLVDFVIQFMEEIDKEISEMKLTLNARARICAEEFLKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0I2</accession>
    <name>A0A6P8I0I2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116294854</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558385.1">
        <property type="nucleotide sequence ID" value="XM_031702525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0I2"/>
    <dbReference type="GeneID" id="116294854"/>
    <dbReference type="KEGG" id="aten:116294854"/>
    <dbReference type="InParanoid" id="A0A6P8I0I2"/>
    <dbReference type="OrthoDB" id="6279276at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF62">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="3">
        <location>
            <begin position="117"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558385.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="76319" checksum="764F35AA746D478C" modified="2020-12-02" version="1">MVFLSIMEVKVLHEGNLEKCSSADDHGKKDWKRRYFVFKYFPASSTRCLEYYKDKSWRKQDPKGVLTLHPGYEVVKVHDSKRKYVFDVKTVEHVFRLSANNEDELNKWILTLERENIVKSFIVEPVPSGVMNRTGATEKCHLHITDTEVRLISAQDGNQFVAWPFTCLRRYMSSRGKFSLEAGRRAPTGEGNFVFITPQHDEIYKLLDNVIKSRAGNNVPIPMPPNQPAKVQRSESMQSTLSIQSVASTAVPEEDGYDHLMCSPLAGFKPVHPVHPNYDQNIIHSPQKTENQKSNNYEAPYGHMKNRESLASMRGQMSFDAKASEYNTLDPEKMTSKIPSSTGKGNDILEPSRPQKPPPPLPANFDRNTMTEHQNDGVHSPSSQMYDNNQSPVSQDTNTYDSLDHGTSVPKQGIPACISLTNAFHNMRNSMETEDTYNVLSYPGSSVSSPEVKNQPVQGDGGQNADEHRSNISQHTSFRQSMLQPLVPPRKNEVSGQAIPVPPPRVPRNDRTSQGVDRSSVSSVSSMGSSFCPLDMSGSYRDSQLSMSADQDFYSSIGEKSSPPKSQPASAYRGSRMGPDSPTEPKQIAPKPRKTGTQANKTHENLVSNLKATLLADGLNLSKILPSKIAQRRSSADAIPENDTYAEVDDGDSKGSYKTRIARSPSAPMNPIEDIYEDPEKSSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1U3</accession>
    <name>A0A6P8I1U3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116295232 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116295232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558857.1">
        <property type="nucleotide sequence ID" value="XM_031702997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1U3"/>
    <dbReference type="GeneID" id="116295232"/>
    <dbReference type="KEGG" id="aten:116295232"/>
    <dbReference type="InParanoid" id="A0A6P8I1U3"/>
    <dbReference type="OrthoDB" id="5974012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059">
        <property type="entry name" value="ANTHRAX TOXIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059:SF25">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028425501" evidence="7">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558857.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34738" checksum="5B0D32A261C06491" modified="2020-12-02" version="1">MLNKTVFLLVLWIGFSIEDADGACDLKFIKIGCFKDDQIEPRPLPELLFNDRDGSSGQEIDWKNWDKYVDDITCRCAKAAAKNRFGYFALQFYGECWSGQDAGASFPRAGRSSHCVSKGFEKCAERSRKNCVGESLSNFVYMMLAHESLCHVKYEKVGCYNNNRAFPILLFTDSNSNSPKYSNVSLDLSHWNSYIMDLTCRCAAKTKEHNYKYFSLQNFGGGKSSRPRARMKKKLCCGGLAGIDSSRKNLPDWMIAILIFLGVIALYMMYALTRWIYVKRLQGTLFRYRKEIDRSETSDVVSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I271</accession>
    <name>A0A6P8I271_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116298357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562634.1">
        <property type="nucleotide sequence ID" value="XM_031706774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I271"/>
    <dbReference type="FunCoup" id="A0A6P8I271">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="GeneID" id="116298357"/>
    <dbReference type="KEGG" id="aten:116298357"/>
    <dbReference type="InParanoid" id="A0A6P8I271"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031562634.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14602" checksum="144C5A9D6A0F8E5E" modified="2020-12-02" version="1">MLSRVVKEHNQKQAAHKDVQERRKREAAIEASKLTYRLMDTLNSGVEKAYVNQRKLETEAKQLQAHVAQYSKQTTLWLKMVESFNQSLKELGDVENWSRVIEADMTSIASALEYAYKGDGPQSTELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2G0</accession>
    <name>A0A6P8I2G0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 184B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116295384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559040.1">
        <property type="nucleotide sequence ID" value="XM_031703180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2G0"/>
    <dbReference type="FunCoup" id="A0A6P8I2G0">
        <property type="interactions" value="1436"/>
    </dbReference>
    <dbReference type="GeneID" id="116295384"/>
    <dbReference type="KEGG" id="aten:116295384"/>
    <dbReference type="InParanoid" id="A0A6P8I2G0"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031559040.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="51419" checksum="7A67EC16671411D0" modified="2020-12-02" version="1">MMDFTADITNISTIFPPTNVTTPQVLQSQQIFFQTAAARGISGLFVMLALLITCHQIYQHLSYYTNPSEQRWIVRILFIVPIYAFDSWLSLMFFEQSYYVYFDSIRDCYEAFVIYNFLSLCYEYLGGEMAIMTEIRGKPIHSSWLYCTCCLAGSQYTILFLRFCKRATLQYCVIKPIMAVITLILQPLGYYSDGDWRADRGYLYIVIVYNISVTLALYALFLFYQATKDLLSPYYPVLKFFTVKSVIFLSFWQGVVLAVAEKAGFIRTYHNISAGTIAAGYQNFIICIEMFFAAICLRYAFPYSIYLRQRKLDERGQGIALKSISKNLKQTMNPKDIVDDAIHNFSRSYKHYANAQNPKSFGEDHVVHNMPTSYQSTNFDGLESQNSFDAHAYPEPEHYDSFDSFRRGMHVTVIDGSHSNHGSHGNHVHKKKDTEKATLLYSDSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4C1</accession>
    <name>A0A6P8I4C1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295952</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559772.1">
        <property type="nucleotide sequence ID" value="XM_031703912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295952"/>
    <dbReference type="KEGG" id="aten:116295952"/>
    <dbReference type="InParanoid" id="A0A6P8I4C1"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559772.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40670" checksum="1D3DF1821F1FFCB8" modified="2020-12-02" version="1">MNAPVLPPMSPLPPSPTQNYDEDMLQLLGSPFNLPDDVMSVLSSDTPLSTGSNLVRAMDPPSPEPSPGPSPDRTPGVSPTFSPSASPAASPPSEVANLAXWTPSSGGRLTSLPDATLDQMNKEELREYXEALKSLAEKYPQVKETLTPTIKNVMTRVDGRWRGNRSEKRMDLAEVEEYVKELEATDQSKFDETSQMRIRYALEKALARRLQLRKEAERERRDGDDDDNNDDHGERFKNADQDTVSKALRKKLGKGDHQTIANTTTVTTVRRGKRPVVEREHNSQTFPGPGSDNDEDGDDATIEGGVLRRKRKSRVSKSKPRRKKHSQQGGIVADMNPYGGYNKSPHEVVDQYIQFLRDAKRKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5X7</accession>
    <name>A0A6P8I5X7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SUMO-conjugating enzyme UBC9-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563343.1">
        <property type="nucleotide sequence ID" value="XM_031707483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5X7"/>
    <dbReference type="FunCoup" id="A0A6P8I5X7">
        <property type="interactions" value="2839"/>
    </dbReference>
    <dbReference type="GeneID" id="116298902"/>
    <dbReference type="KEGG" id="aten:116298902"/>
    <dbReference type="InParanoid" id="A0A6P8I5X7"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000013">
        <property type="entry name" value="SUMO-conjugating enzyme UBC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563343.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18029" checksum="C54B727D1F3B6365" modified="2020-12-02" version="1">MSGIALGRLSEERKAWRKDHPFGFVAKPYKNSDGTLNLMQWDCAIPGKKGTPWEGGLYKLKMIFKDDYPSTPPKCKFDPPIFHPNVYPSGTVCLSLLDEDKDWRPAVTIKQILLGIQDLLNDPNVKDPAQAEAYTSYCQNRADYEKRIRSQAAHFVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6I3</accession>
    <name>A0A6P8I6I3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stabilizer of axonemal microtubules 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560642.1">
        <property type="nucleotide sequence ID" value="XM_031704782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6I3"/>
    <dbReference type="GeneID" id="116296715"/>
    <dbReference type="KEGG" id="aten:116296715"/>
    <dbReference type="InParanoid" id="A0A6P8I6I3"/>
    <dbReference type="OrthoDB" id="9973968at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF18">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560642.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="59803" checksum="2CDA56F7A26EE72E" modified="2020-12-02" version="1">MVLSREYSAATKQLLNDKGLKCVCELCDCGQYHRHDGCTKNIHKMHQVFKRPGMGHVATDYQATYKPHDNTQQRHLKRPLPKLRNPNPPPMDFRTEQRMEFIKREIPGTKPCKMVESYIQPEGKVEGLTVYNEEFINRGPATVPKITRPQTVITQKESKFQSQTTHNSTFTPKKRIPQPTYGEVPSFTGSILFPDPKADMKTTNQEVYKGKYVKVADLCRPAEDQVTIGIEGDHFYGTTHRDTYKTPEMEGRQEARKKQSQLKANQRAKFQSDTQFKSDFPGYGGKMPEPTKPIPPPPETVNLAMNNNRHFLTTNNDFYKIVWDPKTIGKTKILKPDAGTYSKPLAKMETKTQAMRDFTQKEPVKMPQIRPPTRTEPSKSKFHDETAYKSQFKHYRSVPFQRYGDLHESAFYLKPVTKFYQDGSVTMQDFQGATGGKPSTPHLPIQKLHVKGGDILCQTTYNSDYVRKAKEQCSYLQWVQERETQKKAAKITTHKTTEPQTIEKALEQKNQEKSAVMVGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6I8</accession>
    <name>A0A6P8I6I8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116298574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562951.1">
        <property type="nucleotide sequence ID" value="XM_031707091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6I8"/>
    <dbReference type="GeneID" id="116298574"/>
    <dbReference type="KEGG" id="aten:116298574"/>
    <dbReference type="InParanoid" id="A0A6P8I6I8"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="8">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031562951.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49969" checksum="D026AF33D76DDC5D" modified="2020-12-02" version="1">MGAYFSLGLLNEKLNQYHDVIIDTKKCLAIAREIGDKRVAMSSCLSLARTYREIKLENEAIAYCKSCISIAKEIDEKAVEMTACFIVGNLYFSQSNYKEALAYSERSLENTKAIGNKRYESMVYLLIQDCQYHMSEYKDAVVTGQKTIAAAKDIGDKLGEKVAYALLGKTYELLNQHEDAVDCTTNSLELEIKSGDKISAMTEYYSLGKIYHSFGHHDSAIAYVMKCIDMAEETGENRSKSHAYLLLGDIYNSLNKFDEAVMYLKKCLSNSEPVPVEEKLDFQAHFLLGKVHVSKNQFDTAIIHLTKALEFAGYNTKEERAYVYLGLGDSYLQIQQHDKAREYLRKCLDIAKRSGNRRAEGDAYMLLGKTFDSLHKESDAILHLKKGIEILRENGLVQHEMQGHLLLGKMYRSSKNYNEAIESLKKAIVIALRTGDKNMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6R0</accession>
    <name>A0A6P8I6R0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prostamide/prostaglandin F synthase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116296525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560410.1">
        <property type="nucleotide sequence ID" value="XM_031704550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6R0"/>
    <dbReference type="GeneID" id="116296525"/>
    <dbReference type="KEGG" id="aten:116296525"/>
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    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047017">
        <property type="term" value="F:prostaglandin F synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF29">
        <property type="entry name" value="PROSTAMIDE_PROSTAGLANDIN F SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031560410.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="10345" checksum="FEF32F2DB1807306" modified="2020-12-02" version="1">MGGLLAKETRQSLSKSNAKGIKGNMKGDGMQTGGLLIVSQEGKVLFSHSQTSPGDHVPNVTILEALGIKDEGEGGETSAGGEASGGAKMECNEDACTLPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7G8</accession>
    <name>A0A6P8I7G8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564524.1">
        <property type="nucleotide sequence ID" value="XM_031708664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7G8"/>
    <dbReference type="GeneID" id="116299936"/>
    <dbReference type="KEGG" id="aten:116299936"/>
    <dbReference type="InParanoid" id="A0A6P8I7G8"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="1">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564524.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13255" checksum="1C5CF2A4474832F4" modified="2020-12-02" version="1">MYVKKDDDKVKALRAAEQKTDENKKKLNSFTEELDGIQNGHLQKDLIEKAVTKISKQIQGIEENLMKILESLDSLSLGSATLGVKGKRKSVVKWIQDLITEADSQRARCEALQKGQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7X1</accession>
    <name>A0A6P8I7X1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116297139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561162.1">
        <property type="nucleotide sequence ID" value="XM_031705302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297139"/>
    <dbReference type="KEGG" id="aten:116297139"/>
    <dbReference type="InParanoid" id="A0A6P8I7X1"/>
    <dbReference type="OrthoDB" id="5968803at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561162.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46948" checksum="F1FFC77BDBB22F6C" modified="2020-12-02" version="1">MPETSAEAAIVQNPRMSTFQISPPENFDFSQPADWPKWIRRFERFRIASGLASSDEESQVNMLIYCMGDKSDDILATLTLTEEEKKYKPVREKFEEHFVKRRNTIFERAKFNNRKQEVGESVESFITDLYALAKHCQFGELHDQMLRDRIVVGLLDSRLSXKLQLDAELSLNKAIDAARQSEQVKRQQQVVRGFQDPNSDKPSQVNALTGKSRKWKPQNKQKPREKTKEQNKSQQESCGRCGKSPSHPQSKCPAQGVVCHXCKKIGHFKAVCRSEKHVRAVTTEKESVREDTEPELAKEELEPFDPFLGNITVGQVEKSKNDPWSKVVKVNGIEINFKIDTGADVTVVPLSTQRKIPGRLRQSVVTLKGPGELPLKVCGTLAATLEVGDKKVKQDVHIVSDLKQPLLGRPAIEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8Q1</accession>
    <name>A0A6P8I8Q1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563621.1">
        <property type="nucleotide sequence ID" value="XM_031707761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8Q1"/>
    <dbReference type="GeneID" id="116299126"/>
    <dbReference type="KEGG" id="aten:116299126"/>
    <dbReference type="InParanoid" id="A0A6P8I8Q1"/>
    <dbReference type="OrthoDB" id="5975471at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563621.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16373" checksum="A1B80130B2766486" modified="2020-12-02" version="1">MEEIQTNQLNEVLSYLFEPEPTDNSINGSENSDSESQSSSEDEGHQTFDVENAWRLQTLSCCKCGQCTLSTKAIECFCCHERAVEYDEYDGLLSEVEQQRHQRITTHSDFTNNMLSQSVLKVDICRYLEENCTVAHKGKTKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBW0</accession>
    <name>A0A6P8IBW0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564886.1">
        <property type="nucleotide sequence ID" value="XM_031709026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBW0"/>
    <dbReference type="GeneID" id="116300212"/>
    <dbReference type="KEGG" id="aten:116300212"/>
    <dbReference type="InParanoid" id="A0A6P8IBW0"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39313">
        <property type="entry name" value="IM:7138239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39313:SF1">
        <property type="entry name" value="IM:7138239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028250183" evidence="1">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564886.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34277" checksum="51A603C6C9F8E43A" modified="2020-12-02" version="1">MFPLISVLWFVCLSSTSGDTFMGKLFSKGSNGSPTSLTNSAIAMWMQRSGLARRVCQRGISVHTYDSSVSARSASVVTGQCEIQFIKSSAGVPLSPDQKPCPGMQACVPTMSEIINLRTTNGISDVTSAINCACAPKISGCHRRRRLRVFYRNTKFERVVDVGECAGNCGQNRCQPLAIKTVAIKSPNGRKSVEVVEKCGCAHSCYRISYKKAYQVLTKKQKSNATETKVIDIGTCSSSSVCTGHVQGKCLYWAKPVVTSQQTSPFSVSSSSEKVCLLRTKGRPRGCYAEKTRVITLNTLQEPNMKVTVIDSCTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC68</accession>
    <name>A0A6P8IC68_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane metallo-endopeptidase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116298285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031562535.1">
        <property type="nucleotide sequence ID" value="XM_031706675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IC68"/>
    <dbReference type="KEGG" id="aten:116298285"/>
    <dbReference type="InParanoid" id="A0A6P8IC68"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028476683" evidence="7">
        <location>
            <begin position="22"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="58"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="509"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031562535.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="82147" checksum="1F97AE3DCADE884C" modified="2020-12-02" version="1">MMPKLLLVICGVLLTIAIVNSQGSGDDDSDIGANVCVTQDCYQTASDILSSMDLTVDPCDDFYQYACGRWIQQNPADDGKASVDRYEKLRADNDEFLKKFMANSKSRNEYREIKTVIKAFKYYESCMDTNTIDKRSAQPMESLIQRYGSWSITDNNWDERAWNLQDVLIMMLEDFGTKSLFEFNVELGMTNSSYYYISLKQPTKFSIPREKLNSKNGGAKDRRTFRQFMMNVSLSLGAQNSQKTASMLREVLRFERKLAKSALPEESIDYNKMTIKEVQDMLGTNPIDWLYVIRQVLSDVPINITPETTIILNGKRYFRKLKKHLSNTPKRTLANYMMWKLVYDFYLHLGQDFVDIYHDYKAASGSSWQQPDREVTCMEQLLSMRGFALPLTRVFVDKKFKGNKQWILNATEQIRNEFISNLDNNFWMDRKTNEKAKTKAQSLQEVIGYPDFILNSTALDLVFDDVVIDSWTYFENVWSLKKFWVQKNYELIGKERDNDQWNMSPIEINAQYEDSFNRMVFPVAILQPPFYSGKYSSAVNFGGIGSVIGHELTHGFDDSGKNYDEGGRREDWWTDHTLNEFKKRSKCLVDQYSRYQFHGQNVNGKRSLSENIADNGGLKQALGAYRTWVNINGDEPTLPTTNMTNEQLFFVSFAQNWCASFSSEGINEEMTSNYSPTPIRVNGSLKNFDDFASVFDCAPGKPMNPRSKCGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICY8</accession>
    <name>A0A6P8ICY8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116299288</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563777.1">
        <property type="nucleotide sequence ID" value="XM_031707917.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299288"/>
    <dbReference type="KEGG" id="aten:116299288"/>
    <dbReference type="InParanoid" id="A0A6P8ICY8"/>
    <dbReference type="OrthoDB" id="6147321at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031563777.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40100" checksum="FFD1FFA5669486CC" modified="2020-12-02" version="1">MVASNSSQVPKNVKCYLPEISPHFQSEYLKKSHLVVSPLNIICVLMSTILNFLVVVAVYRKRRLRRGSGLLLCSINLKDLLLVSILQPMAVYRSFFLVLNNNFCAKSPIEGLRSYLIFLYRSVALTTMALISFDRWLAIHRPSYYRTFFTMKRTIASIALVWLISMSISFVATYVXQPKHRYQLVFIQFGVTMVIVAVLQLDVYRGIKQHGKKVADLSTSQQRQIXLEHSVSMVVFYVILALIICYFPLLVVSAIRFSNNKNYFLITSPWMEMILYANAVANPIILLKTNVHLKSAVVDAVMQWLSPRFYDNESVDASGLQESRVAVSVVRTNGQNGGNQSRGERRMTVQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IED8</accession>
    <name>A0A6P8IED8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Adhesion G-protein coupled receptor G2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116300430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565167.1">
        <property type="nucleotide sequence ID" value="XM_031709307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IED8"/>
    <dbReference type="GeneID" id="116300430"/>
    <dbReference type="KEGG" id="aten:116300430"/>
    <dbReference type="InParanoid" id="A0A6P8IED8"/>
    <dbReference type="OrthoDB" id="347083at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028259301" evidence="7">
        <location>
            <begin position="24"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="505"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="670"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031565167.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="93027" checksum="DD677E6978C15B4E" modified="2020-12-02" version="1">MMVTKIKGLALLVSIVVLQITKGKKSKFNEGSLDVRSGTKLMINTTSLTATLEGKSIVLGNRTGIAVFDGVEYRNHVVELKYMGNITFHKNSEIIIEGTQPLSIQSSYGNITIATNLSVTCKEKPYAGDTCLGGYMLNYTKPKDCKNIFRGLGPGGNKNSWCTQDSVIRSKCNGGAGHGGFGQIDISHKEHNIGQSYGKTDFKYVIGGSAGNTDSKKTYLSGGGAIEIKAVKGIIFIDAMIDARARVMGNTTLQKFSGSSGGLIRLKAVKVEMTRKASLNVDGSNGSNYTLQKGGDAGNGGGGGGVIQVNASQAQLYNLSLKAGSTYGCRFPRSSSPGCFVFMKDPSEINKTKECKDFIPFYGWPETLPSIDEQLVSVLEQLGTVKAEFEENFSNISDIFALLKQLENITSQNILTEPYLLKVLKIFERFKDILNITTPRLLERAKEAFGALLKVATFIISSRNQQNWKTTRKLPTFVTTLEEMGESIANHTTEHHYNTSLIAFQSISLEAGPTNYILPVHSKLPKDFISTEEAFVNVPSKALPESPRNFKAIVLIFKNIQDGLPESNKDNRTDPYKVVTLLTSYSLFSNGRNIKNLRSPALLHFRLYKQGTNIKCSFWNTTSDSWDSDGLSTHWTNTSNTVCSTTHLTSFAVLMQFTPTTVTELEELSLSLITYIGCSLSCFGFLITLLCLIFMKSLSSERHRIHLNLVIALMLAQVVFLSGVKATEIKLLCQFIAGTLHYLFLASFIWMLLEGVHLYLKVVRVFGVENVKIRYYCIIGWGIPVLIILIPAVLKPGSYGTKNLCWLSLEDGFVWAFIAPVLAIIAINSFILGIVIKTVMSSASAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEG0</accession>
    <name>A0A6P8IEG0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase C</fullName>
            <ecNumber evidence="15">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116300487</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="15"/>
    <dbReference type="RefSeq" id="XP_031565227.1">
        <property type="nucleotide sequence ID" value="XM_031709367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEG0"/>
    <dbReference type="FunCoup" id="A0A6P8IEG0">
        <property type="interactions" value="1589"/>
    </dbReference>
    <dbReference type="GeneID" id="116300487"/>
    <dbReference type="KEGG" id="aten:116300487"/>
    <dbReference type="InParanoid" id="A0A6P8IEG0"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20835">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20838">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000003">
        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000126">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000024">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014376">
        <property type="entry name" value="Prot_kin_PKC_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000551">
        <property type="entry name" value="PKC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="20">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="231"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="380"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="23">
        <location>
            <begin position="639"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="386"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 18">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031565227.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="79996" checksum="7DDDE0061B9D63CA" modified="2020-12-02" version="1">MVGFTGSLKLRIYGAKELKPSAKYHWGVKLSVINPYLLVKVDDVQIYQTSSGTKTSTPVWNASCDANIENGHKLEFTVFHNSVMPPDPFIANSSVLFEEVIKTGLSEFWIPLEPHGQVHVNIELKTAHRVFKENPGGINRRRGAMRRKIHQINGHKFMATYLRQPTFCSHCNDFIWGIVNKQGYQCQICTCVVHKRCHTMVVTKCPGTRQDPSSAEVIFGNGSFRFKMDVPHKFAEHNYKRPTFCELCGSLLYGLLRQGVQCSACKMNVHKRCQNLVANNCGVNPKEMAKTLEIMGLSANEMHVQSVHSKKSSITSVPSVTGSNMNAGKVMPGRTQSSPAIVQPSGDKNGEPGMFHMQDRKTSPGERRRILIRKLALRDFTFLRVLGKGSFGKVLLAERKGSSEVYAIKILKKESVLQDDDIECTMIERRILALSAGHPFLTSLHSSFQTEARLFFVMEYVNGGDLMFQIQKARKFDENRSRFYAAEVVLALQFLHQHGVIYRDLKLDNVLLDAEGHVKLADFGMCKENMAPGKTTTTFCGTPDYIAPEILQELPYGFSVDWWALGVLMYEMMAGQPPFEAENEEDLFESILKDDVLYPVWLTREAVSVLKGFMTKSFHKRLGCGTMGEQSIREHQFFRPINWEKLAARQVAPPFKPKIKSRTDVGNFDTDFTREEPRLTPIDKNVITNIDQKEFKDFSYVNSRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEI9</accession>
    <name>A0A6P8IEI9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Carboxypeptidase B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116299718</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564295.1">
        <property type="nucleotide sequence ID" value="XM_031708435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEI9"/>
    <dbReference type="GeneID" id="116299718"/>
    <dbReference type="KEGG" id="aten:116299718"/>
    <dbReference type="InParanoid" id="A0A6P8IEI9"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028485009" evidence="11">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="26"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031564295.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37602" checksum="B6C88A16F562FA9F" modified="2020-12-02" version="1">MMTVFIVIVALLQAFLVHSDDSWHDSYHNLDQIVAKLKEINSSSENTELFSLGTSTEGRQMYAIKISGKKSENKPVMYIQCLSHGNEWITGTQCMYFADKLSSLYGSDSKVTKTLDKMDIVILPVMNVDGYVYTRTYSYMRNWPKSRRRVTYIGSKICYGVDLNRNFGYQWGFVKNQFDPTIERCHNTFRGFGAFSEVETRNVRNYLNRVGKNLKGFLDFHGHGRQAFQMPWKYDYGSNPDKAEQKRAATEAVRAIYKVGYRQSYYSCCEAVYTGRHGGSSVDWVYGRLKVKYTYEVSVSARSGYALSGVAQGLLAGINALVNTMQLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF46</accession>
    <name>A0A6P8IF46_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565270.1">
        <property type="nucleotide sequence ID" value="XM_031709410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IF46"/>
    <dbReference type="GeneID" id="116300531"/>
    <dbReference type="KEGG" id="aten:116300531"/>
    <dbReference type="InParanoid" id="A0A6P8IF46"/>
    <dbReference type="OrthoDB" id="10294902at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565270.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33253" checksum="53C00286395FE418" modified="2020-12-02" version="1">MRDKETRQCGLPSVGCKTSTCNSLTMSQLTEHYKRKQRLNDEMRDKTYNKDVPRREIKRPYLLKLPKIIQQQQPIIQVPPKKESGTSKNQRNSVSELKLPVIKSENEKKTSTRNEYQLKDSSQLGRGSVNKAFYSSATEFRAGLKRETSKIDQGMDQNKLYDDSKGIEQRADRLNGIEMKIDCRITEALDNLRVPIVDLETSTSTNNGPKTISCNEYAKKMMLRKKKSWKDRRREAKLFDINLLNPQRAMLTSSATARGLKVLKANEVMIYRFCLSNYSEVDFHTVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF87</accession>
    <name>A0A6P8IF87_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Glutamate receptor ionotropic, kainate 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116300623</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565386.1">
        <property type="nucleotide sequence ID" value="XM_031709526.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IF87">
        <property type="interactions" value="1038"/>
    </dbReference>
    <dbReference type="GeneID" id="116300623"/>
    <dbReference type="KEGG" id="aten:116300623"/>
    <dbReference type="InParanoid" id="A0A6P8IF87"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000399">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000400">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027852068" evidence="19">
        <location>
            <begin position="27"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="844"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="445"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="455"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="687"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="769"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031565386.1"/>
        </source>
    </evidence>
    <sequence length="918" mass="104344" checksum="705BA33EAB3A6F48" modified="2020-12-02" version="1">MFCLKVFWRSLLFLWILLLNFFCAESFPTEVKIGRIFCKDCDMTEKRAFLLGIKYINNSTSILPNVQLLVELNDTDWLDSFNNIETVYWQIYKGAVAIIGPMTSPMVKITYPFCEGFGVPQIAPYATDSPFEFSSHFYKYFLRMSSSDSIENQVIADFIAHFNWTRLALISSRSEYGLNGLVTLKDIASHNGWQILAYETFQEHKNIXLINATNQLMHIRSRGARIIILNCIAMYVPSILKQARDLGVLKNRVWILTSGAFGPHEPFYTGMTAPDYLRGVVGIRHTFGHGQMSDAFKTAWKSAGYPEISFGNEAAAGHTFDAVLVLAEGLQNFFDHGYNISNVTQKFGIYTKSETAPRPEGKYLMEYLSNVNTSGVMSDNLAFDSSRSPVQDEFEVVNLRTYGFEKVGHWNPKVRLVMEPNKEIVWSSGKVDIPSDSTHLIENRTLKVVTIEEHPFVYMFTSEKDGKKEYRFSGYCIELLDKLAEKMKFNYEIYPVSDNKFGSLDSLTKEWNGMVKELLQGKADIAVASFTISPERQRVIDFTQPYINLGLTALIKSVTKTSEYFSFFRPFRYDMWLAIGVTMIVVGFFLWFFSTFSPYGYYGRCVQTCLSRVHPEHLKFRDTLTLVRSLWSTVVYYVGQSSDHLHPVSSPGRITVAVWWFAILIIMSSYTANLAAFLTIQRFSSPVKTVGELAQQRSISYGTVQNSQPQAFFETSTIPSFVTMWQYMQYHQTLVKSSSEGIERAKNENYAFIWDSVVLEYIAHKQNECGSLITVGSLLGKIGYGFGLQKDSPYTQQLSNAILELRHKGVMDILEKKWIHSDERCSGKPGAAGEDGNQLGLGDLAGIFIVVGAGIAISFVVLAFEWLWAAHKDTEVEQEDTASKPSIISALHSRRIRAFHDWRHREDIPKVRKHATLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHM2</accession>
    <name>A0A6P8IHM2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caseinolytic peptidase B protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116301217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566098.1">
        <property type="nucleotide sequence ID" value="XM_031710238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHM2"/>
    <dbReference type="FunCoup" id="A0A6P8IHM2">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116301217"/>
    <dbReference type="InParanoid" id="A0A6P8IHM2"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF93">
        <property type="entry name" value="MITOCHONDRIAL DISAGGREGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="286"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="6">
        <location>
            <begin position="480"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="8">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031566098.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="70157" checksum="DBEC6475DAE0EAD6" modified="2020-12-02" version="1">MAAVFLSFCRFGRHIFVNNSSIIKRKAILLLRLTSTRAVAWKPLGILSKRDGQWRLLFGVGGCCLSAGVALCYATNVIQKLCRSTKDNNVLELERLLKQGHDVNQKHSLGWAPIHVAAINGSDRALQLLLEAGADPNTLEEFSSAFKVAQKKQRGTYEVILERENTFSERLNKGANFSGFTPLHYAALADSYECVQLLLNAGADPTIKDDTGHNAISYTREQSIINIINEYTTKFVEEKKRKEAEERRRYPLEKRIKEHIVGQEGPILTVAGAIRRKENGWHDAEHPLTFLFLGSSGIGKTELAKQIANYIHKGNKKGFIRLDMSEYQEKHEVAKMIGSPPGYIGHDQGGQLTKRLQECPDAVVLFDEVDKAHPDVLTVMLQLFDEGRLTDGKGKTIDCKDAIFVMTSNLASNEIANHALELRQEAHEAALMRKDKNEITEQVTISRKFKEKVVQPILKRHFQRDEFLGRINEIVYFLPFSRTELLQLVSRELEHWCKTALKRHDIHITWDREVMDVLADGYDVYYGARSIKHEVERRVVDQLAAAHERELIEHGSTIHITVDYSLQHENHRKPSKEQRDVSVTPMIKLQLVKEGSKKVDIDIKSDLNHEDYKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIU6</accession>
    <name>A0A6P8IIU6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031566438.1">
        <property type="nucleotide sequence ID" value="XM_031710578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIU6"/>
    <dbReference type="GeneID" id="116301508"/>
    <dbReference type="KEGG" id="aten:116301508"/>
    <dbReference type="InParanoid" id="A0A6P8IIU6"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000020">
        <property type="entry name" value="Dual specificity protein phosphatase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF533">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE VHP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="156"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566438.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36814" checksum="AB1619268C7E09DC" modified="2020-12-02" version="1">MQSILSQQLAEYILGHNLQKLLIIDSRSFLEYNDGHVTQSINIGCSKLIKRRLISNKITIHELLKGTSEETTQDHCQVVVYDQSTMDTSSLAKDNFMFVILNKLVKSFKDVCFLKGGFSYFSKTFPELCESHSNSTFHKSPRTILSQPCLTSEFESPSHILTFLYLGAQEHALDADFRKANGIDFVLNVSCLCPVPANLDSSTHYMRIPVRDSVQENIIDWLPTAFEFIDKAREANSRVLVHCFAGKSRSATIAIAYIMKHLGLPLDEAYRFVKEKRPTISPNLNFMGQLVQFEKDLTPSPNDFKQESFGHQLMSSGSLTELTANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJH5</accession>
    <name>A0A6P8IJH5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Glutathione synthetase</fullName>
            <shortName evidence="15">GSH-S</shortName>
            <ecNumber evidence="4 15">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116301868</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:72075"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:189406"/>
            <dbReference type="ChEBI" id="CHEBI:189750"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:72076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_031566892.1">
        <property type="nucleotide sequence ID" value="XM_031711032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJH5"/>
    <dbReference type="FunCoup" id="A0A6P8IJH5">
        <property type="interactions" value="1140"/>
    </dbReference>
    <dbReference type="GeneID" id="116301868"/>
    <dbReference type="KEGG" id="aten:116301868"/>
    <dbReference type="InParanoid" id="A0A6P8IJH5"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="19">
        <location>
            <begin position="214"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="473"/>
            <end position="474"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031566892.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54307" checksum="9FB50EF2B53D897B" modified="2020-12-02" version="1">MDLNLHFDTKNLTEKQVSDLTKSAVDFSLANGVLMQSRKAPGDVEHAPFMLFPSPFPKKLFDQAKEVQQDFNILVHKISQDHEFLKESLQGTITVDEFTGRIYDIYEQTRKEGIAQPISLGLLRSDYMLDSDKQGATSVKECDEQLNIKQVEVNTIASSFGCLGSKLPGLGSYVLGLTGKNVAVGSQQMPVNSSLAGIAEGLAQAWEFYGSKSAVVLMVITDNETNKFDQKLLEYYLCQRKPSIRLIRRSLTTLYKVASLDNKKLMVEGYEVAVVYFRAGYTPENYPSEDEWSARLLLERSLAIKSPTAALHLVGTKKVQQVLAEPGVLERFISDEASLRRIKKTFTGLYTLDEGPEGEQTVKMALQDPEKYVLKPQREGGGNNFYGDDIKTTLNKMKNAHERSQYILMDKIRPPSFKNYIIRPELEKPVLTDVISELGIFGVLISLGDKVLVSKEVGHLMRTKSIEHQDGGVASGRANLDSPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKL1</accession>
    <name>A0A6P8IKL1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">von Willebrand factor A domain-containing protein 5B1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567486.1">
        <property type="nucleotide sequence ID" value="XM_031711626.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IKL1">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="GeneID" id="116302343"/>
    <dbReference type="KEGG" id="aten:116302343"/>
    <dbReference type="InParanoid" id="A0A6P8IKL1"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052627">
        <property type="entry name" value="VWA_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46299:SF4">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46299">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13757">
        <property type="entry name" value="VIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="291"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567486.1"/>
        </source>
    </evidence>
    <sequence length="1228" mass="138952" checksum="DBE64D6100E594BE" modified="2020-12-02" version="1">MTGLVNRHSIQSLPLKASSIFAEVNGFAARVLATLTYFNDCEYDIEGLFVFPQDERTTIVEFEATVEERHLFTEIKEKTSVEYEKSAYPIEEREDDLFSLSIGRIPPQCSVFVQVSLITXLLSDPKTRGSLFVLPSVFTPRLSSKDEDDDNHNDRYGSQILISDIPRKTHEPYSFDLQLEVVAPSLLAGCSSQTHAIQVDADSRATNASRIHITIAEPHTYDRELEVLLHLSHPYDPYVLIEEGKRILRDKENFTCDTTDSEDLIENFAQKPAVMINFTPQLKSFSKTVTEFLFLVDRSGSMSGKHIFQVKETLILFLKSLPSNSYFNVIGFGSYYRSLFQESQQYTDETLEKAISYIQKMRADLGGTNLILPLDFIFDQPRKNGVPRVIFMLTDGGVSNTLDVVDLVRKNSTNTRFYTFGIGPEACPYLVQSIAGSGSGKSWFLAEDERIPPKVMEALKESLKPAITDIEISWHLPEGYDVIQSPSQLPFVFDGERLVLYGLLSRPPSEEKESPRTPQRRRMDRTMRSFSNNSVKVFWFDDDMEYLPEEQLLLEIEEPERQADDDDDNFFQNEQEFGFENFVDPLGVNTRRTINNNEIQQNRKSIDCLTKRARSTSPPRDHSSITTEDRDSPVDVQGTRSTRDSHGRHRSSSSSMIDKNDVVHNIVFGDFFKDINKSSESVSNQAKDPDNGSQQKEETNDGTHQTDAQSKRHQYALEKEGHGKGDMSVEQKKSETKKLNRSHENEDGNACACDNKETASQETSRYHERDSGVGFSMDDSDKPFEEDQSSNDLCSEEEKSGIRPPTEGTTLFHEDLERSDLKSYTVVKDSDMLGTLGLPKNFGAVSIKGWVGDEEVEQVIPFPINRSGGSSKRPTIHQLLARSLIRELQVSEENPSESMRKILTITKQAKVHSRLTAFASVDQYCFEDEILSALQFPNKETSPNLGKRNVLMLERKCGFTTGLGRRLPSPEGSDQESIESESTEITMGNGEEPADLYRLDRSGTIDSCDSNVTRTTALSRSYHAGRQFPPLSTRYVVGEKQTTTSVNHKSSALSGRLSPVLTKPLKDYQPFVDLAKLQFRNGYWEQDERFAECVGLPLFSIQQASPLADNTVCVSKDLEELMKGYKCDYGTQLWATALGLAWLCRNHRDYQDEWFLLARKADTWLEECEYPRGFTRADIKKLAYQALVLMRRKELSQGSSSLSESPLEKTTDVAVQTVKPSHTWCNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILL3</accession>
    <name>A0A6P8ILL3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Microfibril-associated glycoprotein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567699.1">
        <property type="nucleotide sequence ID" value="XM_031711839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILL3"/>
    <dbReference type="GeneID" id="116302520"/>
    <dbReference type="KEGG" id="aten:116302520"/>
    <dbReference type="InParanoid" id="A0A6P8ILL3"/>
    <dbReference type="OrthoDB" id="5967953at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567699.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31248" checksum="419A55E88196BC45" modified="2020-12-02" version="1">MSCVHQCTRMADSCTSVNFKKQPTNGLHSCQLMTSDMYGQPDALQHDQEFDHTTLQLPTFPSCHEIRQNRGTVNGVYSITPSPSHPIQVYCDMVTSGGGWTVIQKRIDGSVDFYRNWADYKRGFGNKLGEYWLGLDNIHRMTSQRSYRLRVDMEDFEGNTRYAEYGLFKVADESVNYRLTVGQYTGTAGDSLSLHSNMQFSTKDRDNDASSSRDCANEYPSGWWHTSCHFCNLNGLYLNGAGSAFGKGITWFLWKRLHTYSMKRMELKIRPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM74</accession>
    <name>A0A6P8IM74_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 186</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116302689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM186 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567897.1">
        <property type="nucleotide sequence ID" value="XM_031712037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM74"/>
    <dbReference type="FunCoup" id="A0A6P8IM74">
        <property type="interactions" value="1946"/>
    </dbReference>
    <dbReference type="GeneID" id="116302689"/>
    <dbReference type="KEGG" id="aten:116302689"/>
    <dbReference type="InParanoid" id="A0A6P8IM74"/>
    <dbReference type="OrthoDB" id="6147888at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026571">
        <property type="entry name" value="Tmem186"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031567897.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27887" checksum="3D97308240A1833B" modified="2020-12-02" version="1">MYCAFRSSTFLLRASRGISSKGTRFDIPLNCGLVPALQGFTSAKHGHFLTNNYSTNLKKIQDSKEIIYRYKWIKQLRFISRVKIVHVFIVGGLTGPMSYWFNQGIISGSVLVTSIFAATATTAGLFALSYFFRRVIGELSFDPIKEEITISSLTFWGNRRNLVVPISNFIPLSDRDFDPKNLFHRVELYGNDFVYLLNLRHGRVYDSERLLQLLGILQERVKNADSYKPASGHIVEVESGDTVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INB9</accession>
    <name>A0A6P8INB9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicular inhibitory amino acid transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303181</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568541.1">
        <property type="nucleotide sequence ID" value="XM_031712681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INB9"/>
    <dbReference type="FunCoup" id="A0A6P8INB9">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="GeneID" id="116303181"/>
    <dbReference type="KEGG" id="aten:116303181"/>
    <dbReference type="InParanoid" id="A0A6P8INB9"/>
    <dbReference type="OrthoDB" id="6021076at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="44"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568541.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48061" checksum="5BD56CAC62B2ECAE" modified="2020-12-02" version="1">MAKSILEEKAYHLLSSKEEAPSYTEEKTEAISIDEEPTEEEANKSTMWQTVCNLVSDLEGTGLLGLPYVLKEGGWLAVVMLTVVPFMCFYTGKILIECLYDKNNKDEKVRIRRNYRDMAEASSPKYGGIIVVAIQVVELTLLASLYLVLCGHLIHAMVPVLSLNAWMLISAVVGLPSIFFKHLSQVAWISLISLIALTIAIIIVLGYGFSQSLQWDIRAIALWDIKGAPISLAIITFSYICHPCLPAIEASMKDPTKYNAMLGITYAFVFMIKIVFSVMGLFTFSTNINEVITNSLPKGKLHILVNSFLIINVLFSYPFRVMTIIHCVEDSVVPESCRSKFNDILWFVGIRVLINFITLLPAIMVPHFALMMSCVGSLTGMSVVFVLPCFFHLRLKSGELEWYQKGLDYFLIGFGVIVAIIGLILSGRALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IND8</accession>
    <name>A0A6P8IND8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116303031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568332.1">
        <property type="nucleotide sequence ID" value="XM_031712472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IND8"/>
    <dbReference type="FunCoup" id="A0A6P8IND8">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="116303031"/>
    <dbReference type="KEGG" id="aten:116303031"/>
    <dbReference type="InParanoid" id="A0A6P8IND8"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF86">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031568332.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31579" checksum="9E2E0D98E95F173D" modified="2020-12-02" version="1">MAPRIVVITGCSKGIGFSTAVLLAKDHLKRYKVYATMRNLDKIELLEESVKEELNQTMFIKQLDVTSDESVTDVLESIYNVEGRIDVLVNNASIGLMGILETHPAQLTRQVFDTNFFGVVRLTKAVIPKMKSNREGHIINISSMAGVNGVPFNSIYSASKFAVEGMSESLAPLLKKFNVKLSIIEPGPIATEFNTPDTNTDDQYEGVDEETKQLLANAVTKMESALANMAQSPDEIAQNIADVLVEENPHLRYQTNKMYTMATADKLTDPTGDKTLETIYQKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INP3</accession>
    <name>A0A6P8INP3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">DDB1- and CUL4-associated factor 1</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Serine/threonine-protein kinase VPRBP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">LOC116303289</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="30">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex. Interacts with DDB1; the interaction is direct. Also forms a ternary complex with DDA1 and DDB1. Interacts with NF2 (via FERM domain). Component of the EDVP complex, a E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1. Interacts with DYRK2; the interaction is direct. Interacts with RAG1; the interaction is direct. Interacts with LLGL1 and LLGL2. Interacts with histone H3. Interacts with ESR1 and LATS1; probably recruited by LATS1 to promote ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation. Directly interacts with TET1, TET2 and TET3 (via C-terminus). Interacts with CEP78; promoting DCAF1 localization to centrosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VPRBP/DCAF1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031568666.1">
        <property type="nucleotide sequence ID" value="XM_031712806.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8INP3">
        <property type="interactions" value="2515"/>
    </dbReference>
    <dbReference type="GeneID" id="116303289"/>
    <dbReference type="KEGG" id="aten:116303289"/>
    <dbReference type="InParanoid" id="A0A6P8INP3"/>
    <dbReference type="OrthoDB" id="6019818at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000055">
        <property type="entry name" value="DDB1 and CUL4-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129:SF4">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="VPRBP PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0804">Transcription</keyword>
    <keyword evidence="19" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="196"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1305"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="1308"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00063313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00071147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00078221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_031568666.1"/>
        </source>
    </evidence>
    <sequence length="1362" mass="151852" checksum="3BBE6B70B54BA5CD" modified="2020-12-02" version="1">MAALDSAAEISTLLDQWKKDEEERRSPTETLNRMSELLERENDAYHKLDPDPFDDRHPGRADPDCALGHILKALFKNDEFMNKLVVSYIMSTREDFELNCTAARLLLNVMPGLESAMVFQDTDGLLNRLFSWAQDGKEPLRSYATGLLGFAMESQEVAGSYREENSVVVPRMLRRLHILKDLTDLTQPAVEDILAKATPKSKTTKNRSEGTGSSSSGASKGKKMSTDSAVASRGASTNGATVNGESVDSTSSSHSTNCLSKAKSTPSGKNYLVQKSSKAFKLLPAKKIYSCIPASFSLYPLSLAMQQRLIVQYLTPLGEYQELLPTVFELKALDLVIHYIAFKGTVDMHLSFEALKYLASLLCHKKFATEFVTHGGVQRLLDVPRPTVAATGVSMCLYYLAYDEDAMERVCLLPYPVLNDMVKYALWLLECSHDSGHCHATLFFSLTFAFRAVLELFDLGDGLRKLINLLSTLPILRVEEAEILNDDEVFGSRQTVKHTCMALRKYFTAHLHVRADSARRMHSRNVGGTPPVPVPAYKAASLSQESLLDNVDLMLEHPSAAVVWSPLAMMNSLQGFNLMLQIVALSSDWRGYSCRGDVTRLALETLFVLTVYPKAKLALCEQITLPSGEAESGMRLLLKAAEGELVSDIDIQIWALRVICNCVCGPKPKQLHLALLLRGRGVRLHRGPEDIVTKMWSCVRNNNGIKVLLSLLLVKTPLVNADLIRALACKALCGLSRSDKIKQVIGKLQLFNSGQLQILMLDPVLEDNMADHMVFCKYAAELLERVTGKPLGNTTSAVPSLSRITKADVVAQTRITYPAKELLQLIYNHLVSNGLHETAQQLLKEAHLPQLKQQIISPMTNPKRLSSSSISTTLGSILNSPSKTPAPSRYRFGAPGTPAEKRLLPNMLSPPHRSQAPPTLDAIVTRFLREQHAQCSNPVSVCPPFSLLSSHKCPEAKFKHFAPTNITTRLTRREIYPRHGGFNGARSSRKFVYSRFRPLRGIRDTEENSVFTCASFLPDGKTIALGTRNGELKVYNFYTGEEEVTYSCNNAAISMCQPNKNHDCILTSSPFGMPPCALWSIGEIFEMKFSFPDDHYVRFSNVSQDRVIGTDADTAHIYDASTGQLIFTLSDSTSANHYWKNVACFNPTDDLVLNDGVLWDVRGKRVIHKFDKFNNYVSGVFHPSGLEIIINSEVWDLRSFHLLNTCTSLDQCHVVFNNSDDVIYGIKHVPDTEDSMMTQRMLGPFESSFRTFDATDYQPIATIDVKKTIFDLATDPMDSLVAVIENQTSTEESICRLYEVGRSRRFDTEDEDSEDEGEEDQDDEDDDDDDDDGDDDDDDDDDDILISDRDYESDEDDDVMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP10</accession>
    <name>A0A6P8IP10_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Complex III assembly factor LYRM7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">LYR motif-containing protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116303246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UQCRFS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568619.1">
        <property type="nucleotide sequence ID" value="XM_031712759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP10"/>
    <dbReference type="FunCoup" id="A0A6P8IP10">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="GeneID" id="116303246"/>
    <dbReference type="KEGG" id="aten:116303246"/>
    <dbReference type="InParanoid" id="A0A6P8IP10"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="9">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031568619.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11978" checksum="38570DFFA03B61FD" modified="2020-12-02" version="1">MSTLRSKVLACYKSLHRARLKTFVGDAAALEAGRKRIRQEFIKNKNEKDITKIEELLKTAKDVEKMMLQYVVQGVYKERENKYHIRITEDTALEKNAPLPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPJ2</accession>
    <name>A0A6P8IPJ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303399</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568782.1">
        <property type="nucleotide sequence ID" value="XM_031712922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IPJ2"/>
    <dbReference type="GeneID" id="116303399"/>
    <dbReference type="KEGG" id="aten:116303399"/>
    <dbReference type="InParanoid" id="A0A6P8IPJ2"/>
    <dbReference type="OrthoDB" id="5959730at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568782.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="55673" checksum="576CAE82496C3964" modified="2020-12-02" version="1">MSGQHRKVSRSIDSSSGFVTSRSHLTQPENELKQKLNAIDSSIKISNKKINNETRELRQILYGLQRDLKVSKSVGHYVPSPIEEQETTQTKRVRRVTDATAPRDPQLLHRSEIIPKSSTEVKKTIQEFPGVTHGTSTKRRRKMSVPPIISGKILVKDGDVFGEKERELSATLSKPKPLGVEESGNETQRENNGEQETGVKSNCEEVQTNKSEHKTVGVSIHCDNDGIQIGDQIPSARDQGSSETSQVKPSSLSLDNQLDSSYIDVDKKMTNIPSTYKGIATILSREEWSSAQMISKGNSSGNVTSNLKYLKEGRRRSLSENETAYRETFKGKFMTHSLPPASDHVRDIIPPPDPEKRTRRITVAGAHPLGGRSRLDIGDIPRTPFHSGSRRISVNSMHEDGSRKSRSLGRGPTGGGQTVRRGSDEEETDKRLLSTPSRDIPRYRRTSKVSSLPPLKEERKIQNEGNQAAIEWKNLENCRYLRKDDYEISIEDIFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPS0</accession>
    <name>A0A6P8IPS0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17 18">Histone-lysine N-methyltransferase PRDM6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17 18 19" type="primary">LOC116303623</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16 17 18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569053.1">
        <property type="nucleotide sequence ID" value="XM_031713193.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569054.1">
        <property type="nucleotide sequence ID" value="XM_031713194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569055.1">
        <property type="nucleotide sequence ID" value="XM_031713195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569056.1">
        <property type="nucleotide sequence ID" value="XM_031713196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303623"/>
    <dbReference type="KEGG" id="aten:116303623"/>
    <dbReference type="OrthoDB" id="5962159at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001174">
        <property type="entry name" value="zinc finger protein 527 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF22">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE PRDM6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="110"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031569053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031569054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031569055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031569056.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="66686" checksum="BAEAC79A51735E17" modified="2020-12-02" version="1">MNTHSPSKIPSKTLQPRQSGDDDTKQETTLTYEDLYNYLYRRNEIKAINVNEINQQNRGKQATEIFWCDVCQHESTAVCEKHKAEYSKPKSITDTDKEYKLSSAIASFPNEVQLCRSSIPGSKYGVVTKCYIPKGTWLGPYEGTKVRPEGVTLGTDATYMWEVFHEGKLSFYLDGSDEDSSSWMRFISCARNSTEQNLYAFQYCGNIYYRAFKEIPPGTELLVWYDEIYPHFMGIPLEIHETEGIYQRAGDPNKKDNEVVVVVPPYIHASCSLQDIPTAHARMVNPASSQINPALPGVSAVNSYARTSHQASSGFNPADLPLDGRTRSSWQQPGHSVASPVPVSHKEPGETSELLKRRKKRASLRRAQLPWQHAANVPTSPGSELLLKRPNSGVEVTGGQPLHYQSTPXSSPGTQIETRSLEESLTSGMPKSDPYNLHIQLDSSSEPSPSLRNRSSSNHERAGSSDSSPEARIRPEGINNDDNEFQCGQCGKTFPQRSVLQIHVCPKAPYKPYHCGHCSQLFSDPNELRNHAIIHINEKPFKCGYCSRSFSGATTLNNHIRTHTGEKPFECSVCGKTFSQASQLSRHEKIPGDCVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQL9</accession>
    <name>A0A6P8IQL9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116303902</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116303902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569371.1">
        <property type="nucleotide sequence ID" value="XM_031713511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQL9"/>
    <dbReference type="GeneID" id="116303902"/>
    <dbReference type="KEGG" id="aten:116303902"/>
    <dbReference type="InParanoid" id="A0A6P8IQL9"/>
    <dbReference type="OrthoDB" id="5949043at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028400909" evidence="5">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031569371.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23415" checksum="EE7862CEC10F2E0F" modified="2020-12-02" version="1">MNTLHLSSFILHLLHTVASEEAFRASNSGVFSFGNFFSHKDHKLVAAKLKEEKVESSDKCLVRCVQTHGCLSVNVNRTTGDDQGLYVCELLASDKYENQSNFTPSKGINHYSIVSPCEKKPCKHQGKCVPIYKNQTYKCECPAGTLGQDCEILIPVFRSCAQRFAAGYTNSGVYEITTPNTSKIDVYCDHGNGLQVRQLARLEGMLRLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRB8</accession>
    <name>A0A6P8IRB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acid-sensing ion channel 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116303424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568813.1">
        <property type="nucleotide sequence ID" value="XM_031712953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRB8"/>
    <dbReference type="GeneID" id="116303424"/>
    <dbReference type="KEGG" id="aten:116303424"/>
    <dbReference type="InParanoid" id="A0A6P8IRB8"/>
    <dbReference type="OrthoDB" id="6502088at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF296">
        <property type="entry name" value="DEGENERIN-LIKE PROTEIN DEL-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568813.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54601" checksum="210A838D3358ECD3" modified="2020-12-02" version="1">MAVSMKPSWSEFASNSTLHGLRYVVGVSSWCRRSSWLFCILTVTGIYLYFLAESVQQYVSKPINTHTSHEFPEDGMNFPLVTICNRNAVMKSKADIGYDDERFKKLKLDLPACDTIRHVSGNLTCGQALLCAYHKYGSNVVENCDNNMVDKLRNALNTSSRIFNPEEFLRVYGHDIETMVVSYCRFSTDYVCSDKDFQPVMSPKGLCYEFKPKTKDGRPLKVQYTGGDGALNVVLDTQTNEGTFGDWSIGFLAIVTWYGEVANRNRGFNVFPGSHAIVGVIPKMVKRLPAPYKTNCSERHLPGYTLYTKDACVAQCFNNATIAACGCRLEGEPGFPDIPVCSIQDAQCRTKAQENTNLAACWCSMPCMERYFETTISYSKFPNKVGISIIQKRFKLNRSEEYIRNNLVYLQIGFVELAYQVDEQIPAYGPSSLFGDIGGNMGLFLGCSLLTVVEFLDHICILLLNKVRGDKKTNDIHNNQSTSTLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRC6</accession>
    <name>A0A6P8IRC6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303919</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569402.1">
        <property type="nucleotide sequence ID" value="XM_031713542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303919"/>
    <dbReference type="KEGG" id="aten:116303919"/>
    <dbReference type="InParanoid" id="A0A6P8IRC6"/>
    <dbReference type="OrthoDB" id="5985347at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569402.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19952" checksum="C1120A80EED85883" modified="2020-12-02" version="1">MHKLSSDGVRDNELKWSDSYLSSRYIQTTCGLEVSQPLPCNIGVPQGSILGPLLFIIYISDLPDVVRHSQVSLYADDRVLYXFSSSVPDIEXKLNEDLKLVHLKDIERVQEFKYIGVVFSSNMSWSAHVEKQMTKIKKRLGLLKRIKHLXPKFARLLYFNSLVLPLFDYGDIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRL4</accession>
    <name>A0A6P8IRL4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC116304097 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116304097</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569613.1">
        <property type="nucleotide sequence ID" value="XM_031713753.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569614.1">
        <property type="nucleotide sequence ID" value="XM_031713754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304097"/>
    <dbReference type="KEGG" id="aten:116304097"/>
    <dbReference type="OrthoDB" id="5980237at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1460.10">
        <property type="entry name" value="GTF2I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004212">
        <property type="entry name" value="GTF2I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036647">
        <property type="entry name" value="GTF2I-like_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46304">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46304:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02946">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117773">
        <property type="entry name" value="GTF2I-like repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51139">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031569613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569614.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47986" checksum="3592C7654F43B914" modified="2020-12-02" version="1">MLQALSRKIQCRKCLSFEKQTLFYSYHAKQDPYASMEMKERNVAIKTLYINQTEEEKKRWQMEAREVQXNPYSPEVVKKMKTQLQSQFQFLEKAGVRAVCLLNXQNDTIWSLGSSDADHFLDSHPEVEHAYRTFLSIPQKYSNNHVKELFNTKFAESLNKPGAVVSYTKYNQGKFTVEGMPAGVPFQKPNVYGATQISKIMESKEAIRFIIKDKDSLLTRNRKPCEKKDFIHSQQSQVLLKVVDEEVVRSLLNKERKGCESDLDVTIALSLAEKKILASCLEYFDTDGQILIKEICKVNNQSVSEEDIVVIPCYADTTTEEIFWLFQTKETELHKKKISGRWLELVSEPMSYKIWSSQDEEIEKGNAVLRKDDFIRLVPGRDFHVNQSTHYVTFTSHSLNDIDTFMRRLFNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRP2</accession>
    <name>A0A6P8IRP2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304039</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569547.1">
        <property type="nucleotide sequence ID" value="XM_031713687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRP2"/>
    <dbReference type="GeneID" id="116304039"/>
    <dbReference type="KEGG" id="aten:116304039"/>
    <dbReference type="InParanoid" id="A0A6P8IRP2"/>
    <dbReference type="OrthoDB" id="10270162at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569547.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21840" checksum="F9854B90DCC7740C" modified="2020-12-02" version="1">MNYLTRKNFVVGFLALLAASYIFVLKLGQDINNHLATELQSSNTDVHRENFTPTQSPQISTLPLDQVTQDLSHIPQNPVIPLGKTQIFTENQSESYIKFSGMDLPREGDFPCADSLARGSCLIQRKKMSDFELFCDRIGPYCKGFVLKKDTDHHQTFAYFKRKLGDLKPNKNTDLFVKREFLVKKDRIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS18</accession>
    <name>A0A6P8IS18_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytosolic 5'-nucleotidase 1A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569682.1">
        <property type="nucleotide sequence ID" value="XM_031713822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS18"/>
    <dbReference type="FunCoup" id="A0A6P8IS18">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="GeneID" id="116304153"/>
    <dbReference type="KEGG" id="aten:116304153"/>
    <dbReference type="InParanoid" id="A0A6P8IS18"/>
    <dbReference type="OrthoDB" id="9994138at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046085">
        <property type="term" value="P:adenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010394">
        <property type="entry name" value="5-nucleotidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367">
        <property type="entry name" value="CYTOSOLIC 5'-NUCLEOTIDASE 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367:SF5">
        <property type="entry name" value="CYTOSOLIC 5'-NUCLEOTIDASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06189">
        <property type="entry name" value="5-nucleotidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569682.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52952" checksum="E988216619D56828" modified="2020-12-02" version="1">MNFRILMVSRSILRDMFAKNCALFGSRFVRSTETGKRHMRSVAQALRYFTLRYRVMKDDVLLFRIKFSLSTMAAIKEDVPSTSPSEEPVEKIAKKEVSKTSLEKHIRSLPGTDSSRTVNVAVSSRALFDLEEENEIFEKKGLEEYIQLQVSREDKFLKPGSAFPFIKALENVNAKLREIDPNEREIFSIALMSHNNANVGIRLQKSIDHYGLIVTRMALTGGTSPVEYLKAFNITLFLTSYEDQVTEAIHRGTSLHRFILGPTGDVIVGTSDSQCARGSIPGLGVICFPAAVMSLQPMNNPSETQLRIAFDLDAVLFSDESEKVFKAKGLDAYIEYELQNREIPLTEGPLKPFAEKIGRMQKKFDRSKKESCPIRTYIVTSRDAVLGQRALKTLREWGLEIDECFFMAGAAKDEVLKAINPHIFFDDQITHVARAREKGTPSGYVTHGISREYDAKKREQAKKDLTNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU72</accession>
    <name>A0A6P8IU72_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116304187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031569738.1">
        <property type="nucleotide sequence ID" value="XM_031713878.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IU72">
        <property type="interactions" value="1795"/>
    </dbReference>
    <dbReference type="GeneID" id="116304187"/>
    <dbReference type="KEGG" id="aten:116304187"/>
    <dbReference type="InParanoid" id="A0A6P8IU72"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031569738.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39222" checksum="54E21B51544DA474" modified="2020-12-02" version="1">MASVPPSVAIESVLSKSDPMPENAETVKGFDFGKGVDYHALLKSFKHTGFQATNFGKAVEEINKMIAKKNEPFQKNEEHPALDLLPNGRPKSNCSIFLSFTSNMISSGVRETICFLVKHNMVDCIVNTAGGIEEDFMKCLAPTYLGDFALSGKTLREKGHNRTGNLLVPNVNYCKLEEWISPXLDKMLEEQNQLGTNWTPSKVINRLGKEINHPESVYYWAYKNNIPVFCPAITDGAIGDALFFHSYHNPGLKIDIVEDVRAINDHAIHAKSTGLIILGGGLVKHHTCNANMMRNGADFSVFINTAQEFDGSDSGARPDEAISWGKIKATATPVKVYGEATIIFPLLVAETFARNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVM0</accession>
    <name>A0A6P8IVM0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571149.1">
        <property type="nucleotide sequence ID" value="XM_031715289.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IVM0">
        <property type="interactions" value="1516"/>
    </dbReference>
    <dbReference type="GeneID" id="116305386"/>
    <dbReference type="KEGG" id="aten:116305386"/>
    <dbReference type="InParanoid" id="A0A6P8IVM0"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="10">
        <location>
            <begin position="158"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571149.1"/>
        </source>
    </evidence>
    <sequence length="757" mass="87114" checksum="7D1A825E5488F00D" modified="2020-12-02" version="1">MPKRVLNEDDKKLHQETEKSLDLFKIKDNKNKTADEGQVNDEDSSDSEESYYSDLEDEESSSEDEKDVPDSDDEESEDDDVDEDDDEEEEDEEESEDEKELGEEETKNQENNNKTDVVKAKNAQNKSKVSSNITEEDAETSDEEDARNTVGNIPIEWYNEYPHIGYSLDGKKILKPATADELDEFLSKMDDXNYWRTVRDKTTMKEVVLSDEDLAIIDRIQNLQFPDQGYDPYEPYVDFFTGDKMIHPLSNAPEPKSRFVPSKWEHKRVMKIVRAIRNGWIKPKKTEEDKPKYYLLWDKDDDETRRHTVHIPAPKMKLPGHEESYNPPPEYLPTEEEVAEWEDMDPEDRPQNFLPKKYSSLRLVPAYNNFIQERFERCLDLYLCPRQRRMRVQVNPDDLLPKLPKPKDLQPFPTTESIVFKGHNGMVRCISVDPTGQWLASGSDDKTVKCWEVCTGRCLKTIPMEHAVQSLVWNPNPQCTLLAAAVNDQAVILNPGLGDRLLCTATDDMIESFTPLEDGPESPVEWGVAGIDEYRSGIRLIIKHSKAVSQITWHSKGDYFATVLSQGGNKSVFIHQLSKRRSQCPFKKAKGLVQRVSFHPNKPFLFVATQKYIRVYNLTKQELAKKLMSNVKWISSMAVHPKGDNVIVGSYDKRLCWFDMDLSTKPYKTLRSHKKALRQVAFHQHYPLFASASDDGTVIVCHGMVYNDLMQNPLIVPVKILRGHKVTSDLGVLDCMFHPHEPWIFSAGADKLIRLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXY4</accession>
    <name>A0A6P8IXY4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Laminin subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116306114</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572019.1">
        <property type="nucleotide sequence ID" value="XM_031716159.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116306114"/>
    <dbReference type="InParanoid" id="A0A6P8IXY4"/>
    <dbReference type="OrthoDB" id="5977026at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000094">
        <property type="entry name" value="Laminin subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000407">
        <property type="entry name" value="Laminin subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000067">
        <property type="entry name" value="Laminin subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028385417" evidence="13">
        <location>
            <begin position="20"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="17">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="386"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="451"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="709"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="835"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="16">
        <location>
            <begin position="907"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1103"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1207"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1254"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1302"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="15">
        <location>
            <begin position="1349"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="1979"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1403"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1954"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1256"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1275"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1322"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1371"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="19">
        <location>
            <position position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031572019.1"/>
        </source>
    </evidence>
    <sequence length="2170" mass="240860" checksum="D72813835888C4FB" modified="2020-12-02" version="1">MAFAILVVILTLHTDFIVGINGALSTSTTNAAFKKYVVAKKTCGSPPEKYFSSSQNEVPPRFRESQFCNASSPTDSHNASYLVDGNRDTFWQSTSMVNAANITIDFSGPMHKYYYVDSIEIEFGEFYRPMQMAFEKSTDHGENYIPWHYYVSEENPENQCQEKFNISLGSKPAYVDNIICTQYPDPVALPKDQKVEWKPAFLRGEPNNPTVKLVDWMNVTNIRIHLLTLNKPYDPLAVLWYHYAVREVKVIAYCDCNGHGVSCNYNETIGDNKCACQPGTCGDKCEHCCPAYNQYAWKRGSKGPMVVDETSACQLCNCHNHSNVCIYDETIERMNASLTMDNKYSGGGVCQNCQHNTEGVNCERCKPYYYRPANRSKLSLDVCESCNCSKAGSRNETLPGVLFRECMREPGQNLLPGDCLCKNNTEGRRCDRCKPGYYNLTEFNPEGCQVCVCNQLGTVNKSNICEPDDKGQCTCKRNVQGVTCDTCKDTFYGLSHDNVLGCQACLCNYGGSNGSVCVKHNGQCPCLENIEGRQCERPEDRAYYPDLHFIGGNTQHNPETNSWSTTFNVTTGRSTNSGLFALLLYYQSDSSQSVTVTVTMSTDTISKSVALDNCSSTCYRNLSQFGEMNLRGVVKVNITYSGANGFEGKRVVALPKEFYQPDILQEGQEDFLGNCSVISNGPIGNSSEEFCKNGVFTITTGYLGKALECNCDPIGSNNLICEKYGGQCSCRPGVTGRKCDQCQAGFYNLTISGCTGIYFVEKKKRRTAENPLQQRRKPTKLFHSSACNCNLTGCEDTQCNLTTGICTCKPGVHLAKCTECKDEYKSFSDDGCSRCDCDXEGSLSXVCDKGSGQCSCKNNTMGLQCNQCKAETFYLNEPNPKGCTDCICMGITKNCSSTTKNIHQRPLESKLWYLFDEENNKTIEADQSLKVAEEGNVSVITANVSSGAKRLVWKASDNFTQNSLVSSYNGNMSFVLHVTNLSGAEVVTNPKIVIESSVSIDQMNRRVIFIKETAWNYAGTSXTVSREHFMFVLAKPLSVHVTASFFGGVILPDVSDSPQERAYEVEQCQCGPEYTGLSCERCAPTHYRINVTNDSFFGKCTRCDCSNHTLDCYASSGQCYNCEHNTTGDHCERCLDGFYGNATDGTPGDCKTCPCEAPKTTTSLCTDDKGQPKCTNCSLGYEGHLCDKCQLKYFGKPHLPGGNCSLCQCNNNSDICNTITGECHNCLMNTTGFHCERCENGTYGYAPRQNCTDCRCDITGSNSSICDHRTGQCYCKPHVTERNCSRCELNSYNFTKSGCTECKCNEFGSNNLQCNESGVCECKENATGIKCDKCEDFFYGLPAAACKACDCNETGSNASKPCDSLXGQCHCKXGVTGRKCDRCMVMHVNFSSDGCDPCPECARTNLQGTLNETQNTLEIALNESMQVEKLKPLKALLDDVDNRVLKIKGLADDFDKRELELSAGIADLKSNTLNKTIVDLQSQLSAMTLYSDTLKQNTSQEIHRVRNITNETENALQYVKSVNELTFNISNQLQALKVSANQMLSHVSTFLNQTFDSESVRAEYELSNASYVNNTLTRISRHNTTTHRNTAEALNTTVTRNEKTSNEKLVEFSRIQSRNDDVKRLVAQVNVLVNQTLVLIGQGDMQLASAGSLLQDAYALLNKSWAEIENGRIALEESNKILNNDLGLNSQMTQLNTSLSPTYSRIQSANLSVNVNATRHAANLTAEAKLRKNVLDSIADNAKRAVDAIKQYESVVKLVNQSLETTAKVNKTLQQIMXRLNNFHSSFSVVKQSAEDSYNKSRDLLDKTQARSIDVAGLQKNVTMANETFQRATLIGRQIDLYHNILLSRSNRLIGLSELGAAEHSIYTDFKNAASYKSNVDQVAPSIWDNSKVVQQEVSRLNSSIAYINASSEHAXQLMPEAFAAIARGNAALVNVTQSXIQVQLEKNKTADLQTQLETNMDRLRKKLEQAKERIAKIQHALKIHGNTTLQYTPTGRIAKKTLYNDISLDFKAERNQVIQGPLLYLAEGLTDXGSSMLLSIVYDEYVRFTFDLGSGPISVINYAVPIRTGSWYRVYASRTKDKARLTVTNYLNNMSRTYESSTNQILPRNYMNITSSSPFFLGSLPNDXLPNVTRRFFYGCIDNVVVNQQRVGLWEPTKVTGKRFTCSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J078</accession>
    <name>A0A6P8J078_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transmembrane protein 258</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116306875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572867.1">
        <property type="nucleotide sequence ID" value="XM_031717007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J078"/>
    <dbReference type="FunCoup" id="A0A6P8J078">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="GeneID" id="116306875"/>
    <dbReference type="KEGG" id="aten:116306875"/>
    <dbReference type="InParanoid" id="A0A6P8J078"/>
    <dbReference type="OrthoDB" id="18408at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13636">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031572867.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9461" checksum="FE13668C7728C1B0" modified="2020-12-02" version="1">MEEMLVESMNRYASPINPAVFPHLTIVLLAIGIFFMAWFFVYEVTSTKYTRDIYKELLVALVASLFMGFGVLFLLLWVGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0Q7</accession>
    <name>A0A6P8J0Q7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Disheveled-associated activator of morphogenesis 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031573049.1">
        <property type="nucleotide sequence ID" value="XM_031717189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0Q7"/>
    <dbReference type="FunCoup" id="A0A6P8J0Q7">
        <property type="interactions" value="700"/>
    </dbReference>
    <dbReference type="GeneID" id="116307050"/>
    <dbReference type="KEGG" id="aten:116307050"/>
    <dbReference type="InParanoid" id="A0A6P8J0Q7"/>
    <dbReference type="OrthoDB" id="6019351at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="292"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="3">
        <location>
            <begin position="718"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573049.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="87298" checksum="F5507689AF95B4D4" modified="2020-12-02" version="1">MLGIQPVIEKLRTMENATLTRHLNFFDMVRTEDEKELAKRYGMPFIDFRSASGMLELLKRKVGHTSSYPHLLSILHHLLLLPNEHSVARHMWQLIDRAIQQVVLQQEDGGDPDVAPMDINVNYIIDSLIQENEGGVEDLKSKLSKKERELESKKEEMDEVKEALDKMVVKLERNNQELQEAMQRIREQDQKLSDFDNEVSERKRLEEVIKSVGGSIPDDLKISKLANALKPSPMSGTAPPPPPPPPPPPGGAAPPPPPPPGPPGGGFAPPPPAPNQANTPGGGFFGFSRQPNRKAPKPSHPLKSFNWSKLPDSKIKGTVWTDIDDSEVYAVMDFEDFDRMFSAYQRNEKDPKDVTDNKPKELSLIDNRRAQNCGILLSKLKMTDEEITNAILSMDEKDELSKDMVEQLLKYVPTPAEKNLLNEHNKNQDQFARADKFLYDMSRIVHYEQRLKSLCYKKRFAERMGDVKPKVQAVISACKELHRSKRLRILLEVVLAFGNYMNRGARGNAAGFKLNSLNNIIDTKSSANSKITLLNYLVSVLEKSYPDVLKLEQDLPHVRTAAKANLNDLESEITSIKKELKELEKELEFQTRKREKTAGDKFIESMSSFVKVAQFSCTELTDAWDELKQKYQKIVKLFGEDPKSVQSDKFFGIFTSFLVSFAEAKNQNEEIKKKREAEERKAKAMVEQKEKDRQKSAARKLMTGSDKSKDKKMASGKGDNRGEFDDLISALRTGDVFGDEMSKMKGRRRTAGPKSTRKNETKNERERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J186</accession>
    <name>A0A6P8J186_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein ZPR1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573661.1">
        <property type="nucleotide sequence ID" value="XM_031717801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J186"/>
    <dbReference type="FunCoup" id="A0A6P8J186">
        <property type="interactions" value="2480"/>
    </dbReference>
    <dbReference type="GeneID" id="116307526"/>
    <dbReference type="KEGG" id="aten:116307526"/>
    <dbReference type="InParanoid" id="A0A6P8J186"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000002">
        <property type="entry name" value="zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="250"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573661.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49699" checksum="80F625A1C328167D" modified="2020-12-02" version="1">MAETEVKKKESVFQELQADEDAGVITVESLCMNCHKNGTTRLLLVKIPFFKEIILSSFHCEHCGEKNSEIQSGSSIQDKGCKISLKITTKKDLDRQVVKQESASFSIPKLSFEVPPFTQKGEISTIEGLITRAVAGLEQDQPVRRHMDPESAKKIDAFLVELKKCLEVETPYIVILDDCTGNSFIENIYAPKPDPNMKTELYERTTEQDNSLGFYQNTSGEEEAEEKKESEEKGKKNKAFDKDEVITIPTNCTSCNAPSETRMKLVSIPHFKEVIIMALTCDTCGFKSNEVKSGSGIEPKGRKLTLKITDPEDLSRDILKSETCTLSIPELEFEAGGPTLGGKFTTIEGLLSNVGDHLKSINPFGFGDGFSLSGGKLKGFLDNLQKIISGQWMGVHIILDDPAGNSFIQNLYAPDPDPELTIEEYERTTSQNDELGILHMNTENYAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1T0</accession>
    <name>A0A6P8J1T0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116307380</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116307380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573474.1">
        <property type="nucleotide sequence ID" value="XM_031717614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1T0"/>
    <dbReference type="GeneID" id="116307380"/>
    <dbReference type="KEGG" id="aten:116307380"/>
    <dbReference type="InParanoid" id="A0A6P8J1T0"/>
    <dbReference type="OrthoDB" id="76126at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031573474.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10908" checksum="428C59A14BCD443F" modified="2020-12-02" version="1">MRYQWIAKIKERTRRMYTLWSYYSNLWVYNTQKRFDAIWNGKPRETASVPFMITAKMRKSLTSLGYEERDVRSMTPQDACNIIKNQTKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1Y8</accession>
    <name>A0A6P8J1Y8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031573617.1">
        <property type="nucleotide sequence ID" value="XM_031717757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1Y8"/>
    <dbReference type="FunCoup" id="A0A6P8J1Y8">
        <property type="interactions" value="2383"/>
    </dbReference>
    <dbReference type="GeneID" id="116307489"/>
    <dbReference type="KEGG" id="aten:116307489"/>
    <dbReference type="InParanoid" id="A0A6P8J1Y8"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573617.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34766" checksum="188FE0BC8B9DB0B8" modified="2020-12-02" version="1">MATFRFNFGAKENELNEKIVSLDECGANQKAEEIKVSLDALLKTDVRFSTQEIVINEETVVKTLNIKHLEETLKASDKNTRSCVLDASLSNKDLVPDLYEGGLKIWECAVDLVEFLEQKEVKFEDKRVLELGCGAGLPGIFGLMKGACVDFQDYNREVIEHFTMPNVFLNLKSSHYHFSNQQLESLLSAKCRFYAGDWKCLENYINHNKDPEQLYDIILTSETIYDTRNQSKLLSFIRSHLRYPYGVVYVAAKTCYFGVGGGTRTFEMLVNGSQDLLVTVSKLYQEGVQREILTMEWRQDNSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1Z6</accession>
    <name>A0A6P8J1Z6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 74A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572128.1">
        <property type="nucleotide sequence ID" value="XM_031716268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1Z6"/>
    <dbReference type="GeneID" id="116306247"/>
    <dbReference type="KEGG" id="aten:116306247"/>
    <dbReference type="InParanoid" id="A0A6P8J1Z6"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572128.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="76952" checksum="D1096DE92ACB403F" modified="2020-12-02" version="1">MKIANMKTAKQRELNNNNGQKNRRPLKQIPSIRPLTAPGKEHSGPFKLVDRPNTLSPSTESLLRPKTTVGFYEDLHGYSLPSRPKSASGMSDDAPSVSSTPRSSFSKKPRQPKGSRSPKGRRKSIKPKTHIAWDDTTGTDQTSNDKERLRPQDAKDGDHPFKSPAHSKSKKASFKPMSLVPGSVSTMVALQESEEDEEISENVSDGEIKTPKAPCFADVLISEASSDYDTDLEEDFPEPPRTFDPSGREQYIKSCKQKDLVPVSFLSKRFKEKEIIMRHHGLGKEGTLPIARSLKKNTFTEKLDLTDNYIERHGAIAISQMLVDNCFITEIDLSMNFIRTEGGIAFGQMLYKNQSLKKLSLRSNHLTDKVAKVFADALKENRTLTYLDLSHNEIGELGGIYLGAGLAMNYGLKHFDVSWNSIRFKGAVGLAQALKTNDCLTHFNISWNGLSLLGCVALGRFLKKNEALIELDISNNRIGLLGTQKLAAGISSHPNLKVLKIGRNPIGDVGVECLLNVIRTHNTIKFLSLEDITVSPKIFDEIIELEKERDLKVITGGIGGYKRPKEMPPGMRILLDFVQDNRLRLIDWFNQFDKDQSGGISREEFRKGLKETGLVMTTRQLDRLIKFIDINDDGEIDYSELLRGREITLQELRHEKKLEERNRRIEEDRMKLPKLEGYDYDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2X0</accession>
    <name>A0A6P8J2X0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307769</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573934.1">
        <property type="nucleotide sequence ID" value="XM_031718074.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307769"/>
    <dbReference type="KEGG" id="aten:116307769"/>
    <dbReference type="InParanoid" id="A0A6P8J2X0"/>
    <dbReference type="OrthoDB" id="5970156at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573934.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19377" checksum="C6A2D76505F8AA3C" modified="2020-12-02" version="1">MATSSEQQTHQMQDXPCYTKRKLDTEESYMPLVYENGVFTPKSEKRQRFNGSYSEIEGQSLGQNNFSVNSDAEALNASRSHDQNMEEDNEMMEEKTYSNNMEENSDQNMNVEGICNGVSSEMRTEITKPTIGVDHVNLPRTKTLNCTTPSVHSFCFQGGLLDNMLVNYHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3C3</accession>
    <name>A0A6P8J3C3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307918</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574104.1">
        <property type="nucleotide sequence ID" value="XM_031718244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3C3"/>
    <dbReference type="GeneID" id="116307918"/>
    <dbReference type="KEGG" id="aten:116307918"/>
    <dbReference type="InParanoid" id="A0A6P8J3C3"/>
    <dbReference type="OrthoDB" id="5968803at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048270">
        <property type="entry name" value="PNMA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14893">
        <property type="entry name" value="PNMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paraneoplastic antigen Ma-like C-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574104.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="53293" checksum="6B57CC88DC657B5B" modified="2020-12-02" version="1">MPETDEQATSHPRPPMANTIPPPEKFSGANSPQQSDLWQKWLRRFERYRLASGLKHKPDIEQVSTLLYSMGECADDILQTINIDEEKATYEEVKTALNKYYEVRRNVLVERAKFNKRVQQQGESIDTFIQDLYKLADDCEYGTLKKELIRDRIIVGVIDDTLSDRLQAKTKLTLEETVQLSRQAEARKQSKEVVRGNTQPSTGNNTVNYIKRPTQNNRPNPRNEAKGETKQSKKTAPPSSCCPWCGNRQRHDRKQCPAKDAACLKCKKRGHFQSVCRSQSNPKPKVNEIEDDDSDMPFLGEVLGEIKGGENSWIVQVGINNVTRCKLDTGAAVSVVSDSLPWIKQQPLEPVRQSLMGPGGTRLTVVGSFLATIKYRQSKIQERVYVIKNQSCSLLSRQACVNLGLIRRLDVEVEELNTEAPNFRAEFPQLFTGLGKLQTECHITLQDDTKPFCLYIWKAMTVFVGYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5D7</accession>
    <name>A0A6P8J5D7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573148.1">
        <property type="nucleotide sequence ID" value="XM_031717288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5D7"/>
    <dbReference type="FunCoup" id="A0A6P8J5D7">
        <property type="interactions" value="3182"/>
    </dbReference>
    <dbReference type="GeneID" id="116307134"/>
    <dbReference type="KEGG" id="aten:116307134"/>
    <dbReference type="InParanoid" id="A0A6P8J5D7"/>
    <dbReference type="OrthoDB" id="10062454at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="89"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573148.1"/>
        </source>
    </evidence>
    <sequence length="729" mass="82617" checksum="49A4C32319CF6CEB" modified="2020-12-02" version="1">MKQNRLLLDAQKRELDKNQRMIEMREQRDNALRDRDQAQKGFNLALQDLDISKEEAKNLHITIAGSLEERRQLVAEINTKEEQIRQMSQAIEDLEGQIERQQETINDQTRPEEEREAAQREVETLEVRLAELQAQKENLEKEELYPAFESNLQHDAQEFLCSLIMALQESATSKAKNNTNHTNCSQSLYQPNSNHSKAIESKCNILNVSDINGSIPCCIEHMFQGKLVHQTKCLNCEESKLRYEDFQDVSVPVVEDQPYLDARKKLMLSPTPKKDKESVHTLQWAIGQFASSECLQGDNKYFCENCNTYCEAEIRTCFDRLPGVLTIHLKRFTSSVGLSSKITSNLQTPFVLSVEEWCSKKCQMDSNVYELFGIVVHSGMTSGSGHYETYVRLSKDQDRNYEQKHTVRSGDVHDLKEMKHDFNGSVEASCFEENSDEKCSESHASCNGIKNAPKIDVNGNCIVEENEIKPKLRGKSKRKRTRKADDENMKIENGAEVSEKSPEGSKEAKIKKVGDNTSVEAVESPSEKQTQARTSCISVITRYFQRSRKVSSGNRPKKSSKNRASNENNSNSGKNIEDESKDNGSEVEENEEKLQEIASNEKPKGCGSIESYFKKTSYKSHGKNTAKSPAIRKLHFQGNSDENPICNGNSDSHKETGTTESQNSSSDEEFQRTGSSCYDESLKTGWVHFDDCTVASLSEQDILSILSSSDSSFTSPYLLFYRKIELKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5S4</accession>
    <name>A0A6P8J5S4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308732</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031575072.1">
        <property type="nucleotide sequence ID" value="XM_031719212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5S4"/>
    <dbReference type="GeneID" id="116308732"/>
    <dbReference type="KEGG" id="aten:116308732"/>
    <dbReference type="InParanoid" id="A0A6P8J5S4"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF14">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575072.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41407" checksum="F77775AB7BA0F024" modified="2020-12-02" version="1">MPARFSKTPEIYTTVPTQPKERKPGQLSQEQLQQYFDEGYVLVTKFFTDEELQPVIEAINALVDEVAERLYKAGKITNKHEDASFNDRLTLLEKEFPGAAILVHKIGFMPKAFQDLWSNERLLNVVEQMIGPDIAGHPVWNLRTKVPKNNQVTVPWHQDNAYLSDEANETLMATAWIPFVDANKVNGCMEVGKGGHKKGFLAKHYCCSGPTLYVELKEEDMVKDLDVDMEKDIVLCEVPFGGVLFINNMVPHRSLMNNSNIIRWSVDLRWCNPDKPNGYYDLKESVLMRTSKDPNLKIDWDKFNTDRHALEAGKKEGEKEDDLEPIIIGPWMGRWELVHHNKHTQRFLENENKIKSAIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5T4</accession>
    <name>A0A6P8J5T4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pikachurin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116308739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575079.1">
        <property type="nucleotide sequence ID" value="XM_031719219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5T4"/>
    <dbReference type="FunCoup" id="A0A6P8J5T4">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="GeneID" id="116308739"/>
    <dbReference type="KEGG" id="aten:116308739"/>
    <dbReference type="InParanoid" id="A0A6P8J5T4"/>
    <dbReference type="OrthoDB" id="5951411at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF85">
        <property type="entry name" value="SP2353, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028274403" evidence="5">
        <location>
            <begin position="34"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="108"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="328"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="502"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="544"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="719"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="6">
        <location>
            <begin position="762"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031575079.1"/>
        </source>
    </evidence>
    <sequence length="943" mass="104833" checksum="FB2DEC904B28CA48" modified="2020-12-02" version="1">MRQTMILLKSLLPSSVFLAVMCLLLLQLNYIRAGPIFNGSGRKMSGDEILKNITICDYEKEGCEPIRTETSQTASASPVHEDSPNSMSTMSLKTLQDSKDSTNIMYLIGQPLFHGDSFMVLPKLPFTARRSFELTITFKANSEDGLLLFSGGPTSNQKDFFALVLRKRKVELRFSNGGDIAVLQTAQNITLGIWHKVVVFRDRRDGYLMLDHGLLIRGSTTRNQEQMDLLAPLYLGGIPDNRLTKENISYSAGFKGCVKSLVVDGKRMDLRFPGGEVVRAHNIDECTNSLQECQCQVKDSCHFSDTGEPVCACPLGTAGKHCEREMSLQIPSFTGNSYLTYPSLGDISSKSFTIRLVLKPMSDTGLIMLNADRTSGQGDFFSLALREGNIEFMFDCGSGPAVIRSKNTIMVDHWHTITLWRNGAQGSLTLDDEEPVFGKSQGRLRHIRLRQNLFVGGMKGYQQQPYEVGMNWGFSGCIQKVTINDGEMDLTSPLSGINVDNSDHVCVTQPICLNGGTCHADMDNFKCECYVGYTGMFCEKELTVKMPSFAGSSYLAYPSLGKESEKGFSISLVLKAKTATGLILFSGQHDEKSVDFVSLALRDGRVEYMFDCGSGPVLIRSHLSVTVDQWHTITFSRSGNKGKLVLDDGVAVLGKSPGSFSRITFHNHLFIGGMKDYSKQPLSIGMKTGFVGCIQKITVNSKSLVLSSPHSGVNVVNCDHVCVTHYMCMNEGLCHASMESFKCQCPFGYTGKMCEEAVSIDGYEFDGQSFFTINRKKVTKRISGFNTNIRIDIKTLLRRGVIFFVHQPLLANSSWFLVGLTDGFLQVRIKRKNHQDTFIKSRTRINDGLWHKVLIRRTLSTLFVQIDSGTPRKKLVDRFFLRFHPGEMLLGGFPSQAALIKGSNWPTFQGSIRELMIGGKRVDIKNEVSSQIKARLYRTSSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7U0</accession>
    <name>A0A6P8J7U0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hemicentin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573155.1">
        <property type="nucleotide sequence ID" value="XM_031717295.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J7U0">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="GeneID" id="116307141"/>
    <dbReference type="KEGG" id="aten:116307141"/>
    <dbReference type="InParanoid" id="A0A6P8J7U0"/>
    <dbReference type="OrthoDB" id="5971046at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="207"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="286"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="374"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="474"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="572"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573155.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="78475" checksum="F70E5E33793F398D" modified="2020-12-02" version="1">MASGTVKVTAHXPSXDYIFSLTSKRXXLXCYGRGFPLPNITWTKDGLPVSLSQTDRLMNETFIESRLNLGNLTIDMAGRYFCHVGNDVYLEEPIRIAIDVFLRPVIDVKPTDQKLFEGSTVILPCEASGFPAPNITWLFNNDPIPWEHSIENESLVLNNVRHGRHDGRYTCVATXKXXTXSTSASLIVYVKMFAXALSREYIFSLTSQSANLSCSGSGYPLPNVTWTKNGLPVSLNQTDSVINETFIESILSLGNLTIEKAGRYSFNVGNGVQEPISVAMEILIRPVINVAPTDQKAFEGSTVILPCKAAGFPAPNITWLLNDDPIPWEYSIENDSLLLNNVRHGRHDGRYTCVATSKAGTVFTSASLRVYDEPSSFAKKRRYVFSVIASDYVFVSCFGSGNPRPIIVWEKDGSPVSLNQTDIVLNDTVVESRLHLGNFTPEKAGKYYCYVKSQLDGVYIPTPRKLAILAWFYPAIVEEPVDRETIEGATVVFECKSKGFPQPTTTWLFNGKPIPFEHTIDGDGSLVLENVRRNPHAGKYTCVATSEAGTAKHFAWLFIDGGCPSAWKTYRDSNSCYRIVNTRTAKWDVARRSCISMGGYLVKIDSEEENRYVTKLASEASSAEYMWIGLSRISTDELFRWTDGTSLPSRYSKWDKGEPNNAGGNENCGHLYVRGRRATYWNDHACNYPKLIHVYACERGKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAN4</accession>
    <name>A0A6P8JAN4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116308500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574793.1">
        <property type="nucleotide sequence ID" value="XM_031718933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JAN4"/>
    <dbReference type="GeneID" id="116308500"/>
    <dbReference type="KEGG" id="aten:116308500"/>
    <dbReference type="InParanoid" id="A0A6P8JAN4"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015378">
        <property type="term" value="F:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090493">
        <property type="term" value="P:catecholamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF320">
        <property type="entry name" value="SODIUM-DEPENDENT NORADRENALINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
            <position position="400"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031574793.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="67441" checksum="26BFE272DBD0C44B" modified="2020-12-02" version="1">MAGTSRDSYIYPRNVNSRTYLAEAIEKDPNNVKAEVKLEERENWSNKMDFILSCVGYAVGLGNVWRFPYLCYKNGGASFLIPYAICLFFCGIPIFFLEVALGQYTAQGVVKAWTVVSPLMGGIGFAMTIITFLCSVYYNVIMAWSFYYMFDSFRATVPWKDCSNAWNTEFCSITRKLNCTANCSAPLKLVSPEEEFFERKVLQLTEGIHKPGEVRFELAMCLLLSWIVVYFCVWKGIKSAGKVVYFTAIFPYVVLIILFFRGVTLEGAGKGVLFYLKPDFSLLTSPGVWVDAAGQIFFSLSVGFGGLITYGSYNKFHNNCQRDTLIVSLINCATSVFSGFVIFSMMGFMAHELGLEVKDVVKSGPGLAFIAYPEGIKKMPGSPFWAFIFFFMLFNLGLDSQFVGVETVTTVLADSYKGCRRYKSHITLIFCLVCYVIGLSNITQGGMYVFQMFDYQAGGISLVLVALLEVIGIGWCYGVDNFSRDIESMIGSKPNIFYLVCWKYISPFIILIIFIWNCVSWEGISYGDHQFPPWAEFMGWMLCVASLVFVPGFAIYKMYHYKGSFSQRFKQLLTPDNDYLRAIHKKYGISDITKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAS1</accession>
    <name>A0A6P8JAS1_ACTTE</name>
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        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574823.1">
        <property type="nucleotide sequence ID" value="XM_031718963.1"/>
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    <dbReference type="FunCoup" id="A0A6P8JAS1">
        <property type="interactions" value="326"/>
    </dbReference>
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    <dbReference type="KEGG" id="aten:116308520"/>
    <dbReference type="InParanoid" id="A0A6P8JAS1"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21341">
        <property type="entry name" value="TTC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000300">
        <property type="entry name" value="Tetratricopeptide repeat domain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028796">
        <property type="entry name" value="BBS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
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    <dbReference type="SUPFAM" id="SSF48452">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574823.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="57619" checksum="A74429C11B123EAF" modified="2020-12-02" version="1">MAAAVQLPMQMDPLFLSLSFFRRRKHEECVDVCTKMLQKNPYDQSAWCLKTRALTEQVYVDEVDVDEEGIAEMLMDDNAVAQLPRPGTSLKKPGTGAGGGPTPGVRPMSQAGRPVSGFVRPGTQSGRPGTMEQAIRTPRTAQTARPVTSASGRYVRLGTASMLAQPDGPFINISKLNLSKYAQRPNLAKPLFEYIFHHENDVRNALELASRATEEAQFKDWWWKVQLAKCYYRLGMYRDSEKQLKSALRDTETVDTYLYLGKVYRRLDQPLTAIETYKKGLEKFSGETTLMTGIARIHEELYDMNNAVKLYKEVLHYDNTHVEAIACIATNHFYTDQPEIALRFYRRLLQMGVYNSELFNNLGLCCFYAQQYDMTLNCFERALALASDETMPDVWYNIGHVALGIGDMALAYQCFRLALASQNDHAEAYNNLGVLEMRKGHNDQARAFLQAAASLSSVMYEPHYNHALLSFKIGDLQSSYSSANKAMEGYPDHSDSQQLLKQLKEDFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JB10</accession>
    <name>A0A6P8JB10_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574903.1">
        <property type="nucleotide sequence ID" value="XM_031719043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JB10"/>
    <dbReference type="GeneID" id="116308579"/>
    <dbReference type="KEGG" id="aten:116308579"/>
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    <dbReference type="OrthoDB" id="47732at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574903.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="34187" checksum="0E13C29FBC7D612B" modified="2020-12-02" version="1">MAPTQHFRQKSRATPEAESQRKANKRKKSLKEKIRGVQRLLRQKNLPATVRVAQERMLTMLQENFKESAKKQQEMKMAKKYKMVKFFEKRKLSRMYKSCLNELTVCTDEQREELNSNLQLLKHQWNYITHFPKDEKYISLFPPTPCNNAETRQHKDDIFKMIKEKVDNGELTDTSDMILQSPKEKKSKQSKLSVIKQAIKSSSQQDNTEQGEDAFKTSLVDDFFIDTNPSEEVNEECSNICGTAAVTNKSKYSAMGLSDDKSASHHKVKRLKSEKDIAANKKKKKIKKKGTDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCQ0</accession>
    <name>A0A6P8JCQ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116308118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116308118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574350.1">
        <property type="nucleotide sequence ID" value="XM_031718490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCQ0"/>
    <dbReference type="GeneID" id="116308118"/>
    <dbReference type="KEGG" id="aten:116308118"/>
    <dbReference type="InParanoid" id="A0A6P8JCQ0"/>
    <dbReference type="OrthoDB" id="5972005at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025048">
        <property type="entry name" value="DUF3987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13148">
        <property type="entry name" value="DUF3987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031574350.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="48970" checksum="5F9711D0A1A6EAC1" modified="2020-12-02" version="1">MSNPILRLSCQSEATWASFHQRVSSIPYDYFKLFPEPVFNFLKHKAYSMGSSLGYLVPSLLTSTAYLLANKDASLMISNHLQPINLFMMFVGYPGTGKSPAVESVLKGLKNMDCINAETLISTTTSSGLVKTLSKQGRALLASPELFDVLNKLLKNDEDNASGNVQLLCKLWSGEGSSYHFATESTREINSNTTFSILGATQIQNAATVLYRMDKGHGLIDRFLFTVPFALKPTPQEEEQSIEYLNNQTFKDFDRLFTEIEQMHHNITRTYTLSNAAMDIYKALKTQHVHEVNEAIKNGDIPPKSKSYDLVARLAIPIHVITACVTSLLQQNDQMTCSEEINEDIYRKSMAYVDYLHSQKAMFTEFIHSILNNAKESTKPQPTASEIQSAILKFSGPLVTFQAISKSLRTKAYVSISGGVTSGILVKNTTILEALLTILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYI6</accession>
    <name>A0A6P8GYI6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Venom prothrombin activator oscutarin-C non-catalytic subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548593.1">
        <property type="nucleotide sequence ID" value="XM_031692733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GYI6"/>
    <dbReference type="GeneID" id="116286238"/>
    <dbReference type="KEGG" id="aten:116286238"/>
    <dbReference type="InParanoid" id="A0A6P8GYI6"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="126"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="276"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031548593.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="50413" checksum="CE8A3F50CE933ED6" modified="2020-12-02" version="1">MQVSSSPTTPSSNVNDTNTTKPIYQLDGPYEVKEIESSDGTHCNATIFVFEPAWVSSFSVLYSDNGIEWNEVVASGRRRKVFIGSTESGSVRKFTIVDQSIKVQYVRIVPKTWVNWVCMRVELYGCDSKLSVGISNGLIRQSAITANSSKMGKEPWRGRLNNPFGCWCAAALTDVELYIDLAFVYRLRSFAAQGNPDPMTSEWVTHVSVMYKERVNDDWTFYGSNGVTTVFKTNYDRDGVVKNNFEPKIDASIIKFFRFNYFNAICMRVELYGYRAEMEPLGIENSAIPNDWFASPFRLPGRSRLNGPLAFTFSMTSPPSRFLQVKLGTEKIITGIASKGGVAVYANNFSILYSKDQVFWTYYQEKGITKMFSCNNDGTTKLDAVRNPFTAAYIRIQFNSAITISLVHTGVPFTFEVFGQNGADQRWGTTAQDTADLHDQTLAEGTSTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZI1</accession>
    <name>A0A6P8GZI1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G patch domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549584.1">
        <property type="nucleotide sequence ID" value="XM_031693724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZI1"/>
    <dbReference type="FunCoup" id="A0A6P8GZI1">
        <property type="interactions" value="2238"/>
    </dbReference>
    <dbReference type="GeneID" id="116287106"/>
    <dbReference type="KEGG" id="aten:116287106"/>
    <dbReference type="InParanoid" id="A0A6P8GZI1"/>
    <dbReference type="OrthoDB" id="5842926at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040341">
        <property type="entry name" value="GPATCH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390:SF2">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="440"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549584.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="63431" checksum="AAC58ABAE8F658E8" modified="2020-12-02" version="1">MDEEKDHQNTENDRICYGIVGNILTELHSADVRAFFSQFVEEKGFLCFHYRHRPEVQKDDKQRNSTQDKKEIPNTCCCIVKLYEDKMDGFIKAYNGENWVDKTGKLFSQKARISKIRLNCIFDDSESHYLTKQEKLQNTRTREEFAQDDLKRLPELNPPSVMPNGNVGTPLCVFIDLIRKCKFPPHLIKKLGLTFPRCKKRKYGNVPFDYGYLGGNDEQNDDNDERVDSRLSHESTLEIPKTTDVKETGEKSVDSKREFRYACDIKNSSDSSDSTQSTSHNQKSDILRKPSEILNCSYSTNKKSKRSFKGNNSQLDENTSEKDSSDGELEEWDRHEALHNDVTSQERTKERLFEDYIELKWEKGGSGLVWYTDAAFWKQQEEADFDEETVDDWDVDMSIYEEEDGGDMDARALLQLRLEEQWRKGKNIDLNKVGSFEKHTRGIAGQVMRKQGWKEGQSLGSSQVGITEPIPSDGQKPKSKRGLGYYGEKLKRFHKRARPTREAVISTVYDEKEEKSAELFQSEGPYSIKYRDSIEFVPEKETASTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZX5</accession>
    <name>A0A6P8GZX5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116287213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549719.1">
        <property type="nucleotide sequence ID" value="XM_031693859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZX5"/>
    <dbReference type="GeneID" id="116287213"/>
    <dbReference type="KEGG" id="aten:116287213"/>
    <dbReference type="InParanoid" id="A0A6P8GZX5"/>
    <dbReference type="OrthoDB" id="10066605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578:SF6">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="9">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549719.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42229" checksum="404CA55AE71F5C07" modified="2020-12-02" version="1">MDLWTDLTTSDIPPAHILGQAVYLSWVIQTDTWKKSWTFHVVFFSFCFSFLAIYSVYGVVRSQIRKEKVIRILAYIVHILIGLLGLTRLLTLSVFSSEIKATSVNNNLYKVVSRIIFGIGFPCITSAFALVQISFTEALKGKLSTSKLGNFTFIGLVISFHFLVVLIVGTLTTVISNLFVLFFATKFYFLIMTAVTMVIMLYSGCKVLSHVAEHERALSDLNQHYGSTLALRERTESNTERDKKRSLLKIKIILFLTSLFCLLICGMEIHSIAELAELLAGKDGALAPWSWYVYQTFFRLAELGLAGTILYTMAPQELTDNKNYFNNEKLHWKNIFRQDKKDKSSKKSKNDKGGDVGTMAMVNRAYDQRTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0L2</accession>
    <name>A0A6P8H0L2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein Luc7-like 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549223.1">
        <property type="nucleotide sequence ID" value="XM_031693363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0L2"/>
    <dbReference type="FunCoup" id="A0A6P8H0L2">
        <property type="interactions" value="2317"/>
    </dbReference>
    <dbReference type="GeneID" id="116286786"/>
    <dbReference type="KEGG" id="aten:116286786"/>
    <dbReference type="InParanoid" id="A0A6P8H0L2"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549223.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="46439" checksum="292D2B41AC47AC36" modified="2020-12-02" version="1">MTAQEQMKKMLDELMGTKRDGAASEVDIKFTNEKVCKSYLMGLCPHELFNNTKFQILKQKMDLGTCQKIHNPALKADFVEASKKRDYGYDIDQMEYLKSFINDCDRKIQIAKKRLEDTQDEWDDSEEARAVHDFAEQIGKKLAKAEELGAEGNVEDSMALMKEVDELKIQKRQAEEIYRSKLPPTSIQQQKLRVCEVCAAYLSLYDNDRRLADHFGGKLHMGFIKIRDRLKELQEEVAKKREAKEKERIQRREEREKERRERERKYKEGGDRDRRDRDRNRGRDRERSRERRRNGERHRDRDRERSRNNRSRSRESRRRSRSRDRKPRPHSTSRSRTRSKSRSGSRSRRGGPRSRSMSRSRSRSHSKSRSEIKKREIDATEERNERLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2X3</accession>
    <name>A0A6P8H2X3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116287416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031549958.1">
        <property type="nucleotide sequence ID" value="XM_031694098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2X3"/>
    <dbReference type="GeneID" id="116287416"/>
    <dbReference type="KEGG" id="aten:116287416"/>
    <dbReference type="InParanoid" id="A0A6P8H2X3"/>
    <dbReference type="OrthoDB" id="5948309at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="184"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549958.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41333" checksum="1901833D1BA68342" modified="2020-12-02" version="1">MSSLNEVRDMLLISHSLNIITDEELLLLMLENSGKRSRKSSFPYDDYEPFSLDDMDEDECKSDFRFEKDHIPWLAELLELPEKLSFSGSIKVENVEGLCLVLKQMTNPCQKNDLIQCFGRPITELRMITNKVIDYLYRAHKHRITKWNEEILSSDYLQQYSAAISSKGGVLENCFGFVDCPVRQNNRKIFNEEKPVYSLKYQNVVLPNGMIAHTYGPIDGKRHDSTLLGDSNLLPDLEQFASTPNGHTMCIYGNPSYPIRIHLKAPYKQCKDSELTPEKEAYNKSMSEVKSPTEWLFPDVFNSFKFLDYQNNHKISLDYVSKMHVVCCLVQNALTCFYGNETAKFFNLEPPAIEDYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3K0</accession>
    <name>A0A6P8H3K0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116287630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550173.1">
        <property type="nucleotide sequence ID" value="XM_031694313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287630"/>
    <dbReference type="KEGG" id="aten:116287630"/>
    <dbReference type="InParanoid" id="A0A6P8H3K0"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270">
        <property type="entry name" value="ARMADILLO-TYPE FOLD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270:SF2">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="187"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550173.1"/>
        </source>
    </evidence>
    <sequence length="1140" mass="128134" checksum="3AB77C62A5DFF955" modified="2020-12-02" version="1">MIDDKVSIYATKALLLLAYLIDEQNNNLIMANKEPINYLVTLIDKANQRSNRRYLGFSNSELAEGLAQIAINDANKKQIVASGAIPVLTRLIRGAKSEEEETAAAEALWVLAFDNENKEKMQSDKACMEMLYKLKDSSNDRVKKAASGALWEIEGKQQHSSHLADIADALQDDKPSGATDAATTNHVMISYQWDVQKTLIQVKDRLQAAGYRVWMDLEQMGGSTLEAMARAVENSAVVLVCVSQKYKESSNCRSEAEYAFQLKKDIIPLMMDRNYRPDGWLGMIMXSKLWIDFSQRHGRLDPYIRDLQKELGERGKGNAEIVQVSSVDVVDAKPTVDISEWTNDDVMNWMTSFGLVFKKKNHRVSDKLTGPVLTRLHSLRNESPDFYYSSLKNDIGLSDVFDVMLFTDELEKLHEEMLMMGSGNTKNVLRKAEETPDKDEDHEKPRQLDYDIVNKAPGKPSNDQEKXKNKLKNNDPTRKEIKKDEVKNSNDSDDEELQTPEDVMLKLSERGFSDPTLVSHCQSTPKYLEYFTSIYEAIKLIEEKMEGDDVLSIQRQATVVSSLYSKVKRKTVLGNFLAEIGFARMFKEIYLKLDSGFPELLTYDRELDENLKKASAVENESNKITDTKEVKNSDDQSAESSDKIIDESGNNPTISSNQPIETGLTTEKCSEEVTEVSVGNMMPNNQAIENGETNEKPNAQGVILNATEPNDGPKEGVSDVLPNNQPKDCIQHSNSSNQPTEPNDTKHTNYELKISSGQTDVGSSVQPDSNNHAEENVTENTDKAIDSEEKQITKPSICLRKAQVLLNKIMLSAINYTDACEKMNLAFSEEGVVQLLVDAVAKLKDCTGHHVKYMNEEGGLKKRTVRGGILTKVMGTLHNMAKRVPTRPNFYACHAVKILLPLIEDEVNCFAIDALLIIAYLIDEENNNLIMANEGPIKYLISMISKATEKSIHRYLGYTNSELAQGLAQIAINDNNKKQAEYAFQLKKDIIPLMMDRNYRPDGWLGMIMGSKLWIDFSLPHINKVESSVKDLIKELGVRGKLGDSEIIQVRSVDIVDAKPTVDISGWSNNDVMNWMKGFGLVIKNKSAAANLTGYILTRLHTFRNEVSPEFYYSSLKEDFGFPRMIDVLIFSDELKKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3S5</accession>
    <name>A0A6P8H3S5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287566</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550111.1">
        <property type="nucleotide sequence ID" value="XM_031694251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3S5"/>
    <dbReference type="GeneID" id="116287566"/>
    <dbReference type="KEGG" id="aten:116287566"/>
    <dbReference type="InParanoid" id="A0A6P8H3S5"/>
    <dbReference type="OrthoDB" id="5985171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550111.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8704" checksum="273C6EFAB9A38160" modified="2020-12-02" version="1">MPAEVSEKKEIEKTTWEKLQLPYDPDCVSCKVIGMLTLYGAGILVLSNVKRVPEANKAGKFAMGLFGLGLLGTGTMRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H500</accession>
    <name>A0A6P8H500_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neurotrimin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551429.1">
        <property type="nucleotide sequence ID" value="XM_031695569.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H500">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="GeneID" id="116288744"/>
    <dbReference type="KEGG" id="aten:116288744"/>
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    <dbReference type="OrthoDB" id="5985960at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="94"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551429.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24070" checksum="3388C77DCC1BECBA" modified="2020-12-02" version="1">LPTLQIARNKSLTAEEGDVLFLNCTATGCPTPNITWTKVGNSNALATNKGIRNVLVYHFDRLTKQNTGFYQCEVNNGVGSAIKEAVHVNVIYTPYQTNLTSSVSTACINXSVTLECTXNAQPPAXEYRFYLNDQLVHTSMSGVYQXNVPQVGVYKYTCESANTIRKGNNASVSINIKGSSYTFTSIVRGDEATYQCTAHNGNECPAATARSSITVTFGLQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H579</accession>
    <name>A0A6P8H579_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectin acetylesterase 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pectinacetylesterase family. Notum subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551524.1">
        <property type="nucleotide sequence ID" value="XM_031695664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288821"/>
    <dbReference type="KEGG" id="aten:116288821"/>
    <dbReference type="InParanoid" id="A0A6P8H579"/>
    <dbReference type="OrthoDB" id="2015280at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
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        <property type="entry name" value="NOTUM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562:SF67">
        <property type="entry name" value="PECTIN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551524.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53740" checksum="ADBB10125B1E4AE8" modified="2020-12-02" version="1">MASSVDENSLIRPSHSTLQFQLIKTMILSSCLSSFITIVIISFLLRNTAFINIYLNSSDSKQTEDSVDISRRSYSNEATLILLKHGVKKEAVCLDGSPPGYYFREGYFGGQDNWIIHFFGGAWCFDEEACLQRSKTVLGSSKFFPPHPPKLQGILSSDPETNPDFYNWNLVMLCYCDGASFSGYRLDPVEVNGEYIYMRGRRILEVILEQLLQSKFRNSRRVLLTGTSAGGMAVVIHSDFIRSKLPITTDVRAVSDAGYFVDVPSINGGNIINRHFKKMFEIHNSAIGVNEDCVRAAVPKYRWKCLFPQHTFRFLRTPLFVLQSAYDAWQMIHIRGINCEVPDYDMFRKKRTINXRGISSGHAEHIWAYKHIHGIYCKPPECTQRELQGLMQFRNLTLHALRPVLRSRFSGLVLTSCMEHSQSLYDDTWNKIYVGGVSIQEAVGNWALSRTRSHFHVDCPFPCNPTCSHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H648</accession>
    <name>A0A6P8H648_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551864.1">
        <property type="nucleotide sequence ID" value="XM_031696004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289126"/>
    <dbReference type="KEGG" id="aten:116289126"/>
    <dbReference type="InParanoid" id="A0A6P8H648"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031551864.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33899" checksum="C136257249C08AA2" modified="2020-12-02" version="1">MMAIISDKDWLYLALILITFVAIAGNVLVVVAVWKKRSLRTTTNFLLVNLAISDITSLFFLLVRCVQFMVRLEKGALADYLCKLLLSYNISVTATSGAIVTLTVLAVERYHGVVTPLHSGSRWTGRTLRIALISIWLSSFIVTSPLYIMTGYDEKECRLVYNTTSESFINIYKFFGITVFCFLSFAIISFCYLKIAXSLYSQNKVAVQSMSAASQRARLKRQIHVVKMSVTVTVLFAIFYFPIAIIVIINIATANSYEYYSYYYFGFFAEAGVNPFIYAFQSTNFRNAFKDILKCFHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H813</accession>
    <name>A0A6P8H813_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Enhancer of mRNA-decapping protein 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552579.1">
        <property type="nucleotide sequence ID" value="XM_031696719.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H813">
        <property type="interactions" value="2838"/>
    </dbReference>
    <dbReference type="GeneID" id="116289775"/>
    <dbReference type="KEGG" id="aten:116289775"/>
    <dbReference type="InParanoid" id="A0A6P8H813"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001414">
        <property type="entry name" value="Enhancer of mRNA-decapping protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049404">
        <property type="entry name" value="EDC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032401">
        <property type="entry name" value="EDC4_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21289">
        <property type="entry name" value="EDC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16529">
        <property type="entry name" value="Ge1_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 WD40 repeat region" evidence="9">
        <location>
            <begin position="131"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 C-terminal" evidence="10">
        <location>
            <begin position="1219"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031552579.1"/>
        </source>
    </evidence>
    <sequence length="1347" mass="148523" checksum="D2CBCF3E0F8BBA7C" modified="2020-12-02" version="1">MANTTGMATKYLIDMLNIGGKSADNVGSKDNSENKATEKVEEDETVRESVSVTSSAALASPLNQTKAMSDMSLSEGEIPGFLDGSTPRISLHPINQTIQLKGDGTEGSMCVYGNQVEVISGQNANSNNTASNKIKINQMVKYDWDLKYYRGSLIALGSEFIAYTLKGRSGYVVRLLNPQTATRALIKGFTGLITDLAFAHRNSNTLACVDEGGNVFVWNVREQGDKIEYKIKLHVKRSPTPVSEYHRIFWCPYLPDDEDDEGGQDDVDDRSLAITHDNLAEVIDVAMVVARCDCNEVTVDMLEQGEGYVSIIDGHTKPITDGSLSPDNAVLATASEDGYVKFWQVADMMPEAEHKCLHAFQPHDGAPLSSIAFCDNHIEHEKDVPMWRFMITGAEYNREIKVWCTVEWTCLQTLRFTSPTADISSVLGDSYFKLQLDATARYLVLSDIGRRVLYVLLIHQDRSEGRAHISSITDFQLTQPLLSFVITKVKLFKLKRTDQLVQENGNEDGNDDMDDADNLEELDESELDSLERRKNLMVQLRLYSIHTKSLQELLVHLKPEPSVAPPTPSLISSLNTSIGQGARDALSDLSVETGTGTEASVDLDESDAASDTSASTRPKLIAPDAFTHTTKDASRPESNASNVSSGTLVSALEASQNSVEESVMSSVTSRLSDSTRSSTQETVPQNFFGQPSSVLTPTSLPLPATPPFSLAPDAAAVPIPTFKSSPITPKNTETLFHPNPRGDGLGLDVEAKEERAEDSDGEERSLTPVADVTVEGSEQAEEPSPASVGKDPIAVTKVTKSESTESDEPYGQDEVSEENTPIEDKSTMDSSWMTASDRHSPRDHTPHVNVMKTKKMVLEQGLVSSPVARVDIPPESSRENYQDLSSTLSELLQLVQSQQTHILTLRQEVNTYQTHNRQTISDLVRGEVEKLEETTLERVNGGLAQHSIEENQRLDKALRERQTADKKKQEHLTSTLSQAVTNSITGKLDKTLKNEMKNNVVPAVQKVLAPVQEQLTTTMQQKLTAADAVLKDSINKMVKNKGVIEAIGTSAASALQGPIQDSYRDAFQNTVLPAFERACQAMFHQINDAFQKGTHQYLEKVTMTIESQKRGERESLEPAFEQLQSQLQLLRSESRKDSTNLIQEVESVIQKQLATALHSLREEMVSRFESQVKASLQETVKAEVQQALQEMHQTYNTAVAQETATATPQQVSVDHKKRISDLLKAGHIPQAFQEALTAADLSLVVFVCEGVDSNDLFSQTENQLPQPVLLSLIQQLSVDLLSNTELKHRYLTEALMLLDVNNEVTREHLPGVLQGLCQQLDYAIRHCSGITQRNLKMLLMAAKSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8C8</accession>
    <name>A0A6P8H8C8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Placenta-specific gene 8 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548997.1">
        <property type="nucleotide sequence ID" value="XM_031693137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8C8"/>
    <dbReference type="FunCoup" id="A0A6P8H8C8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="116286580"/>
    <dbReference type="KEGG" id="aten:116286580"/>
    <dbReference type="InParanoid" id="A0A6P8H8C8"/>
    <dbReference type="OrthoDB" id="5989075at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031548997.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22092" checksum="4A8CCEDCF984B8A4" modified="2020-12-02" version="1">MEEPKSQAPPNYQQSSPEQYPIQTPPMMQQGQSMMQQGQPIMTQPGQPMMQPGQPMMYQGQPMMMQQGQMAPMHSQTTSNTNLVMINQQPVSARAAPREWSTGLCGCCDDCGTCWYAIFCKQHLLCDLSQRLGEGRCFVCCCPFPLLSLRIKFRTEQNIKGSLCNDYLTVEFCPLCALCQLAREIDHVQRIQRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8H9</accession>
    <name>A0A6P8H8H9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Formimidoyltransferase-cyclodeaminase</fullName>
            <ecNumber evidence="7">2.1.2.5</ecNumber>
            <ecNumber evidence="8">4.3.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Formiminotransferase-cyclodeaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116289059</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds and promotes bundling of vimentin filaments originating from the Golgi.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the formiminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="7"/>
    <dbReference type="EC" id="4.3.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031551806.1">
        <property type="nucleotide sequence ID" value="XM_031695946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8H9"/>
    <dbReference type="FunCoup" id="A0A6P8H8H9">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="GeneID" id="116289059"/>
    <dbReference type="KEGG" id="aten:116289059"/>
    <dbReference type="InParanoid" id="A0A6P8H8H9"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030412">
        <property type="term" value="F:formimidoyltetrahydrofolate cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.680:FF:000001">
        <property type="entry name" value="Formimidoyltransferase cyclodeaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.670:FF:000001">
        <property type="entry name" value="Formimidoyltransferase cyclodeaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.990.10:FF:000001">
        <property type="entry name" value="Formimidoyltransferase cyclodeaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="entry name" value="Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="entry name" value="Formiminotransferase, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="entry name" value="Formiminotransferase, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051623">
        <property type="entry name" value="FTCD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234:SF0">
        <property type="entry name" value="FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="Methenyltetrahydrofolate cyclohydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="22">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Formiminotransferase C-terminal subdomain" evidence="21">
        <location>
            <begin position="181"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031551806.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="58946" checksum="F25B87E39C8A7837" modified="2020-12-02" version="1">MAKIIECVPNFSEGRDKGVIDAISQSIASTPGVSLLDVDPGASTNRTVYTFVGSPDDVVQGALNGARVAADLIDMRAHQGEHPRLGALDVCPFIPVSNATMDDCVQCAKSFGERAAKEIGIPVYLYGYASEQDYRKSVPQIRVGEYEGLSKRIVTPEWAPNYGPAEFNAKWGATIAGARKFLIAYNINILGTKEQAHKIALNLREGGRGPDKPGRLKNVQGMGWWLVEENIAQVSLNLLDYEETPMHVAFEEATKDAKESKLGVCGSQVVGLVPLDAILRAADYYIKKEDLFIVEQDQKIRLVVERLGLSSITPFDPRTRIIEYMIGESAGPLVSMSLKDFILNVGARTSVPGGGSAAAAVAAIGAALGTMVGFMSYGNKKYESLDPLMRTLIPPLRQTMLDLIDMVDKDTDAFNDFLMAKKLPNNTPEEKEIRNQATEEGLKKAVNVPMSVIVTANKVWPHLVELSKVSNITTKSDLQVGARSIETGVWGAYYNVKINLPDIKDMDFQNKTLKEADEAVSFAQEKCKEVLEILDKRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8K5</accession>
    <name>A0A6P8H8K5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116286389</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548760.1">
        <property type="nucleotide sequence ID" value="XM_031692900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8K5"/>
    <dbReference type="GeneID" id="116286389"/>
    <dbReference type="KEGG" id="aten:116286389"/>
    <dbReference type="InParanoid" id="A0A6P8H8K5"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF300">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031548760.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61658" checksum="C2FF4063921568C5" modified="2020-12-02" version="1">MLSGREISCPVCRAKSRIPPNGAAGFATNTLLVRLIDNIPGRKEKKELEKRLVLCKEEIERKKKIYVQMEAKCNMIARNRELAEGLKKEISTHANKYVEAIKKYEEELCKEVDAFSKQNCGLSSLEKLEKEKIKLEGDLNDAATAVVAVNRALNSENRIEVLEKKEAMTSQLKEYINIPTPSVLEELGEVQKFDMEFSNCQINMENGLGKVFKKQLYSKEVETASVQQNCHTLNSQKENDEATAYIRHLKAMGLTNSNLYKGTITQHIALEFNPFAVAVSPQSGDIALLCRERRKVYLLTTEGHHYNTVHIKHGNLWDVAFSIDNDIIVVNRANNRLLFYTERGQFVNREVEVPRTCLKFTHLSVDEMGRLIVTSAKVSDEDDDEDVVQCLIVYQPDSDISDRMFGRKHLQNPVSRAIFFKGRYYVADCCSDEIVLKVFTVQGEFVSKIPSIPTALPTSGFSLSRDPSSDRFIICCWDNSMSKDFLKIVDCFATRGKTDTNKLFCPQGFPKQVAAQSASGRGKFTYLVEIYNNKKCCNIVKYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8U1</accession>
    <name>A0A6P8H8U1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum lectin 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ER lectin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552839.1">
        <property type="nucleotide sequence ID" value="XM_031696979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8U1"/>
    <dbReference type="FunCoup" id="A0A6P8H8U1">
        <property type="interactions" value="2263"/>
    </dbReference>
    <dbReference type="GeneID" id="116290012"/>
    <dbReference type="KEGG" id="aten:116290012"/>
    <dbReference type="InParanoid" id="A0A6P8H8U1"/>
    <dbReference type="OrthoDB" id="239053at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000001">
        <property type="entry name" value="Endoplasmic reticulum lectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028219631" description="Endoplasmic reticulum lectin 1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="108"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="345"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031552839.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="54661" checksum="D4DFA73F05416C15" modified="2020-12-02" version="1">MRDLFTNFYVIWALLASFVLTVVSFDNFNDNILFGVTWAGPLTLREGQVTQDGKDYISSHDSVFIMTNNNEKYRCLLPSEQIKNKLYSGEDGYGPSPEELLAPLADEARCSYRLEAYWTYELCHGKHVRQFHDERTQKGVKLQEYFLGKAYVPDKKDRKVSEPKPIPEPPITNHKDGKNIARKPLTRKLEGRDMPYFEVVMGNGTTCDLLSGKPREIHVLYFCHPQGNNEILSVKEMSTCVYEMEVITPSLCSNEFYRFEEDPVHEISCHSLDGSANQPQSYTQFLEDQDLDRTGERQTILFEQGKPESDEPEPTKPTPVTKPVTPRDQVPLPDDQLTRDFLNGDYCLQGGTGWWKYELCYGKRVLQFHVDEEHGGRTDVLLGKWNKEEHIKWIRSKKTKTVGSYAVHLYSGGDICDLTGKPRQVQVRLRCKESTHLQEVSLYLMEPEVCHYILGVESPIICPLLERMDQDGLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H976</accession>
    <name>A0A6P8H976_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116286575</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031548995.1">
        <property type="nucleotide sequence ID" value="XM_031693135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286575"/>
    <dbReference type="KEGG" id="aten:116286575"/>
    <dbReference type="InParanoid" id="A0A6P8H976"/>
    <dbReference type="OrthoDB" id="5989706at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35558:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35558">
        <property type="entry name" value="SGNH_HYDRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031548995.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="45929" checksum="6178A31B0FE736C5" modified="2020-12-02" version="1">MPPRQSAHRKRPISEVELTRNTRVTRSRQDPQAPVPPAASKKKANKKGTKKGRPVVPREESDVVDATAGATSSMALSTSMFNELVARVSAEVTKSITPLLTRGLTQTQTANDAAATSTFQQDADNDLTEVPLGQNLQESSNXNVTTGQSPGEKSAETTVDEXVNXANKCVRGEQPEKSVPSQVFQSVGLSLEARIPAKXKSKILSNEFFDFGLLLMNPVTESKYQISVVNRSGDQPALSIEPTSKPRRILNIDTWMSAFRIFVAVYTQAHPGEAPHLMKYGETIQDLASRSYNWKFYDENFRFLRQSQPQLFPWGNIHWELWLQAQVNVSKSSSPLNNNSTVKPNKAGVIPKGFCYRFHRGKECSGCEFKHSCFKCXGNHPGFQCNFRPFTKPIRTSNQSSHFKPQAPNPSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9H9</accession>
    <name>A0A6P8H9H9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone acetyltransferase KAT2A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031549392.1">
        <property type="nucleotide sequence ID" value="XM_031693532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9H9"/>
    <dbReference type="GeneID" id="116286938"/>
    <dbReference type="KEGG" id="aten:116286938"/>
    <dbReference type="InParanoid" id="A0A6P8H9H9"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCAF N-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549392.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46890" checksum="EF9EB77FD90354E5" modified="2020-12-02" version="1">MAATSDSNTSNNTTSDPSKRPGNSHMTPSDFSRPVNLQRIAQKKEQVKSFTRRKKLEKLGVYSSCKAEESCKCNGWKNPNPPPTPPRLDLSQPLASLTDPCRSCNHPLGSHISHLQSLEEDELDRLLCMVVDVENLFMCVHKEEDPDTKQVYFYLFKLLRKCILQMSRPKVESSLGTPPFEKPSIAKAVLNFVLHKFGHLPQREWQIMHDLAKMFLHCLNHWKLETVSMKKQQSQGEHIAAYKINYTRWLCYCHVPVFCDSLPKHDTTTVFGRTLLRSVFSVMRRQLLDKFRAEKDKMPADKRTIVLTHFPRFLSMLEEEVYGENSPIWDDDFAVPQSISINSSRSLSPLVSFTSLTDSSTSTSGLGTTSSTTSSPILNLSTSSSPTIEELSGIKRPHEDDDDAETSAKKPKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA48</accession>
    <name>A0A6P8HA48_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable serine incorporator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549567.1">
        <property type="nucleotide sequence ID" value="XM_031693707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HA48"/>
    <dbReference type="GeneID" id="116287095"/>
    <dbReference type="KEGG" id="aten:116287095"/>
    <dbReference type="InParanoid" id="A0A6P8HA48"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031549567.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57127" checksum="861E6DB50B584C66" modified="2020-12-02" version="1">MATESGGLSPEYYPKGEDENKRIKQRLRNSRPWKILSSFCQKLDYILCCGFIVCRHCFVRCFQLRQSVFSRMAYIGFLLGGCMVSCLMLTPKTKILFSDRFCQTITYFVCDTLRGYSAVYRVFSAIAIFFFIMSLITFGISSSKSARSQLHNNFWGVKIVFLSVLVFSFLFLPHSEYSGEVWVFFGLNGGFVFIILECVLLIDIVHCWNSSCVVRLESCQNNRHAFRLWYTILWLPTITLYSVSIISIALFYVLYAQQGCYNNMFFISFNVYLCLAATYISVNPIVQEKRPRSGLLQASVITTYNTFVTWLALSNAPDDKCNPSRSYLFPGCPFQNVQLLMSLGLMFFLLICSSLRDVSPPQYGKFKLFSSRHAEAPLPSREGIAPDSIEDTPSPEDRPQKVVTDDEEDGVEYSYSFFHVMLCLGCLYSMMTVTNWYRPEEGENLTVKLVSSWGSVWIRISAAIFSVFIYIWTLVAPVMFPDTYKELVFFQFMLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDN3</accession>
    <name>A0A6P8HDN3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MutS protein homolog 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553158.1">
        <property type="nucleotide sequence ID" value="XM_031697298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDN3"/>
    <dbReference type="FunCoup" id="A0A6P8HDN3">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="GeneID" id="116290295"/>
    <dbReference type="KEGG" id="aten:116290295"/>
    <dbReference type="InParanoid" id="A0A6P8HDN3"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000008">
        <property type="entry name" value="MutS homolog 5 (E. coli)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000820">
        <property type="entry name" value="MutS homolog 5 (E. coli)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553158.1"/>
        </source>
    </evidence>
    <sequence length="765" mass="86658" checksum="BF50DBF150710CA8" modified="2020-12-02" version="1">MMDIVETNDFEILKRVKDQVNPDIIITSSKQDERFLAILRGIEGENNEETMFKATEVEILPTIDFSLEVCKRRIISINGLPGMSEHFNDMERNVFFSSLIPFDNINMVRAAGALIKYLEKKRFGLELEDLDVPVPILALKVFSLKDMMIIDDNTYSALQIFRKESHPSVYKQGTSSKEGLSLFGVMNRTRSSLGSRLLRIWFMRPTRNIEVLSQRQKAINFFMLPRNQELVSSLQDCLKNIKNISRILSRMKTAQASVTDWQALYKTVYNAIYIADLCRTFPADVVIATKIKDHFTHELPRVADLINKIVDFEESAEQNRFVVKPGVDPVLDEKKRTYNGLPDFMTKVAREELSKLRSSVTECNVIYLPQLGYLLSIPRTADMKEEKDFEMEGLEFVFLSNNMVYYKSESTKELDLLLGDTQCEITDHETAIMHRLQSIILTHGKTLLGMMECAAELDCLVSLAICARESNYVRPEITSDSILDIKGGRHPLQELCVNQFVPNDTSKEKDKGRMTILTGPNASGKSVYLKQVGLIVFMAHIGSFVPADSAIIGVTDRIFTRIHTRETVSIGLSTFMIDLGQVATAVQGATEHSLVIIDEFGKGTATVDGLSLLCATLKHWLAFNERCPRIFVSTHFHSLIRQKLLPDTAILKYQTTQVIEDGEELVFLYNLVDGYASSSYAGHIARLAGIPDDLVKRGAEVSEMVRCNKPLQRKDSVSWETQRKRCSTIVNRFLELNLEEDDLHSFLSDFVIPASQGLEFHRVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEB3</accession>
    <name>A0A6P8HEB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116288273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116288273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550900.1">
        <property type="nucleotide sequence ID" value="XM_031695040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEB3"/>
    <dbReference type="GeneID" id="116288273"/>
    <dbReference type="KEGG" id="aten:116288273"/>
    <dbReference type="InParanoid" id="A0A6P8HEB3"/>
    <dbReference type="OrthoDB" id="5994459at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028274832" evidence="6">
        <location>
            <begin position="41"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031550900.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22580" checksum="8CF34F5E8EA1BF2B" modified="2020-12-02" version="1">MLFHTVDRLLKHRSYSNRAVFGVVFLTLLAISHRNTGANGECVSKKSQWGYTLEGSAYDSSPADNYPTCLLRCLTDNTRCKSLSYDLAAKTCELSVYSRWNKQWAYKPKTNSIYMEMLGVVEVYSNVTEQSSTPPPTMAAGAAGEPFNAETFCAGKEDGDYSHPTDCNQYVTCSTASKIARPCGVGMNFHPKNKVCDHASNVVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEW9</accession>
    <name>A0A6P8HEW9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major vault protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116291279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554296.1">
        <property type="nucleotide sequence ID" value="XM_031698436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291279"/>
    <dbReference type="KEGG" id="aten:116291279"/>
    <dbReference type="InParanoid" id="A0A6P8HEW9"/>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF16">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="10">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="10">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="169"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="10">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="222"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="272"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="10">
        <location>
            <begin position="323"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="327"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="14">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="463"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="11">
        <location>
            <begin position="525"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031554296.1"/>
        </source>
    </evidence>
    <sequence length="850" mass="94707" checksum="1C5F44A03119F429" modified="2020-12-02" version="1">MNNIVRIQPLQYIHVQDLNTNITVVEVGPKSLILQDNHVLVSDPCPFIVVPPGHYCTIENPVKKPYEPGQQCDLQHGYREIRFHKEPFPLYPGEVMVGVRDPKAYQRGIKKLPVIGPNQAIRLEAXIDHKDGDIDRLAGDMWQLDGPITYYPTPFAEIQSTINANIIHPGQALNLSAMQDLVDKKGKKRVTGEEWLVREPGAYLPGIYEEVKGLAKAHTLTQGVALHMRAKTTCIDALGKKRYAGDEWLVTIDDVESYIPEVSEELVKEVDMAVLSKDEYCVVLDPIDSKGRNQLGIRELRKGVASFFLHPGERLQSGIQKAHLLEADEALVLSATDKFVDDSLSKKVERHPGDRWMILGPVSYIPPIQVKVVTKRKAIPLNENEGLYVRDIRSGEVRSVMGPQSYLLNAYEELWSKELPDNVELILKKGGGHGTEDIRKMAYFDSSVDPNLMSAQGRDKTRVIVYRCPGNTAVQVNDHKKATARVIFGPDLVILGPHENFNVLSLSAGKPKKPNALQTICLLLGPDFITDVFEVETSDHARLMIKIAINNYFDVDRTDPESVQAIFAVPDFIGFVCKNVASRIRGSVAQVPFDEFHRYSVRIIKKAVFGEDEKGDIKTKLSFDANNLVXTNVDIQSIEPVDPNMRESLSKSVQMAIEISTKSIEMSAAHEAKRTEQIAKGQLERQKLINEKEAEEARKKLYELQAVTAAVESSGHTKAEARAKAEKSLIEGESAIELAKLRAEANEIKLTAELHADRVKREGELDFIRQQNQLKVEKAKKLASIQVEKFSAMVKSIGPKTITNIAESDPKSQISLLHGLGVENVLITDGVTPLNLFQSSQGFVHNATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG09</accession>
    <name>A0A6P8HG09_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Muscleblind-like protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554756.1">
        <property type="nucleotide sequence ID" value="XM_031698896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HG09"/>
    <dbReference type="FunCoup" id="A0A6P8HG09">
        <property type="interactions" value="2487"/>
    </dbReference>
    <dbReference type="GeneID" id="116291691"/>
    <dbReference type="KEGG" id="aten:116291691"/>
    <dbReference type="InParanoid" id="A0A6P8HG09"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000001">
        <property type="entry name" value="Muscleblind-like 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000010">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF12">
        <property type="entry name" value="PROTEIN MUSCLEBLIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554756.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45179" checksum="DFF25949D20C8DCA" modified="2020-12-02" version="1">MPSSPSMIVPIMGKDSRWLQVEVCREFQRGKCSRTEEECRFAHPPAHVVIHNGRVTACFDSLKGRCQREKCKYLHPPKHLKAQLEHNGRMLQQQQQMALQPQMLAPLTQQMMTNPSLLPTWQSLTVPTSNGTLIHQPVAFLADPGLAGGPRRLDKSDKLEVCREYQRGACSRDESECRYAHPPRHLNMDTSDGMVTVCMDFIKGKCQRESCKYFHPPSHLQGKVKAAQQQQQQMSLQSGMQEGSRKRAYEAISELSVGEPLRKQAMEVPIIVPGGISPGFPHQGLTTMQFTGLPTVPIMGYPLGLPQQTQQWQQVPSANYMPVEMATPPPTPQNMSPPQPQTFHQPQVPSPPQPMYEPYQYQMLTPQGQCNDMQYCNGYNGYNGYYYTLAPGPPVDPGAYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGI7</accession>
    <name>A0A6P8HGI7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292364</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555524.1">
        <property type="nucleotide sequence ID" value="XM_031699664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGI7"/>
    <dbReference type="GeneID" id="116292364"/>
    <dbReference type="KEGG" id="aten:116292364"/>
    <dbReference type="InParanoid" id="A0A6P8HGI7"/>
    <dbReference type="OrthoDB" id="5978671at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555524.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16815" checksum="6043C787E3C3FA29" modified="2020-12-02" version="1">MSAQIKDKIANCSICQAYATAQPKEPMIATKPPDLPWMQVASDIFYLEGHNYILTVDYYPKYIEVTKLTDMTTSQKIEALKAHFSALVIPEKLNNRQWNTILKFTVQFAKEYGFEHVTSSPRYPRSSGEAEAAGKTVKRMWTKCKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIA8</accession>
    <name>A0A6P8HIA8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116289497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031552300.1">
        <property type="nucleotide sequence ID" value="XM_031696440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIA8"/>
    <dbReference type="FunCoup" id="A0A6P8HIA8">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="GeneID" id="116289497"/>
    <dbReference type="KEGG" id="aten:116289497"/>
    <dbReference type="InParanoid" id="A0A6P8HIA8"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000897">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031552300.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27877" checksum="BF7333F3C30AFBBC" modified="2020-12-02" version="1">MALPRLKTVITRERFYKTAVVLFFHGEEGSAQAVKDNLKSLLLKNFDFDHIRVIYPQAPEIPYTIEGKQLRSVWFDRKTYSPTCPEQMDSIERSCSLVKQLVNDLVTSGIRKERIVLGGLDMGAQLAMHLGYRYLPEVAGIFGLSSHLSPTSTVYHHILKQKQANKDVKFPKLLLCNDHEDRKVTFKWASLTAECFMDLDIESEFQVYYGTEEGVSLYELVNLRDWILDVLPDEKLDTKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ70</accession>
    <name>A0A6P8HJ70_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289848</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552640.1">
        <property type="nucleotide sequence ID" value="XM_031696780.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289848"/>
    <dbReference type="InParanoid" id="A0A6P8HJ70"/>
    <dbReference type="OrthoDB" id="5973779at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="3">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552640.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30342" checksum="71293E755EFB39BE" modified="2020-12-02" version="1">MWMKAAQDYRKHKLVFTCFGCSCIAIPVLIHRGLHGKYGIGFHGLSILFLGLLPFIALWIALRHLKTKRLWLSSLTVATLLSXCLVIYYLSSNGLWCAQHPNVXREMCSKLVQFASFAXSSNVTXWWLTXGDLLAIQRGRQMPIPWEHDIDVCITPEQFPMFEKALRSNFGLFYPEAEILGPGHWYLPIDMAXLGLSSRDAEGVNIDIWTCPQLPGNITRXLYCNGLMNVPGSLNDRNXILKKSYGDYSVIKYAHHNTMCRIWNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJD7</accession>
    <name>A0A6P8HJD7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidine phosphorylase</fullName>
            <shortName evidence="5">TP</shortName>
            <ecNumber evidence="5">2.4.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">TdRPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116289908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>thymidine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031552710.1">
        <property type="nucleotide sequence ID" value="XM_031696850.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HJD7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="GeneID" id="116289908"/>
    <dbReference type="KEGG" id="aten:116289908"/>
    <dbReference type="InParanoid" id="A0A6P8HJD7"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="UniPathway" id="UPA00578">
        <property type="reaction ID" value="UER00638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000003">
        <property type="entry name" value="Pyrimidine-nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004490">
        <property type="entry name" value="PRK05820.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515:SF0">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyrimidine nucleoside phosphorylase C-terminal" evidence="6">
        <location>
            <begin position="357"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552710.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="48220" checksum="2BC308F5F19EBB51" modified="2020-12-02" version="1">MPEFRVTDLIATKRDGEALTRDQICFFASRVATGEISESQIGAXLMAIYLKGMNTEETVHLTDAMVKSGETLSWPEEWGNCIGDKHSTGGVGDKVSLPLAPALAACEVKVPMISGRGLGHTGGTLDKLESIPGFKVSLTPEEMKDVLEKVGCCIVGQNESLAPADGVLYAVRDVTGTVASVPLIASSIISKKVAESLTSLVLDVKCGRAAFAETKKSARFLAETLVNTCEGMGTRCTALVTSMDHPIGKTVGNSVEVAEAIQCLHGQGPDDLEELVCLLGGHLLKSLEKVDSAEEGMEFIKLTLSNGMAIKKFSEMLVAQGVSQEIADALCNPETNPYEYIPLATKSYEVKAQKSGIIKDIDALECASLCGSLGAGRQKSTDTIDHGVGMVLNVRVGEYIKEGETWVVICHRGNLSVEDVEALQNSIVIEESDSEESLPVQSRLIEVISASQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJN2</accession>
    <name>A0A6P8HJN2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292827</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556041.1">
        <property type="nucleotide sequence ID" value="XM_031700181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292827"/>
    <dbReference type="KEGG" id="aten:116292827"/>
    <dbReference type="InParanoid" id="A0A6P8HJN2"/>
    <dbReference type="OrthoDB" id="6126625at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="179"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556041.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27158" checksum="B847153D6547EFD0" modified="2020-12-02" version="1">MASGSSGSCQGCGSLLLSQANMCRFCTQASTGQLDDDNTRADISSTDDEEEEELLNEEEVITYYFRLGFEYKEILHFLCERHQHPISRCTLIRRLKQYGLSRRGITDKEGFNETFAKVRERISELIKGPSSSMGYRAIWHTLRMEGILVPRKVVQDLLKEMDPEGTEKRKKNRLKRRTYNNPGPNYAWHXDGYDKLKQWGFPIHGGIDGFSRKILWLKVARSNNSPDNIAFFFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJP9</accession>
    <name>A0A6P8HJP9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552912.1">
        <property type="nucleotide sequence ID" value="XM_031697052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJP9"/>
    <dbReference type="FunCoup" id="A0A6P8HJP9">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="GeneID" id="116290071"/>
    <dbReference type="KEGG" id="aten:116290071"/>
    <dbReference type="InParanoid" id="A0A6P8HJP9"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031552912.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="14082" checksum="7D51B9DFD251EFBC" modified="2020-12-02" version="1">MNKMASLGSRGAQSLSLGQRVFTAFREWYVYACGYRQIGLHKEDLLIEDDPDVTEALKRIPEDSLNMRNFRIKRAIDVTMKQTILPEELWTKPSEDVPFLDPIIQQVKAERKERELWDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJU9</accession>
    <name>A0A6P8HJU9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031552967.1">
        <property type="nucleotide sequence ID" value="XM_031697107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290119"/>
    <dbReference type="KEGG" id="aten:116290119"/>
    <dbReference type="InParanoid" id="A0A6P8HJU9"/>
    <dbReference type="OrthoDB" id="5961709at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09897">
        <property type="entry name" value="H3TH_FEN1-XPG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tesmin/TSO1-like CXC" evidence="2">
        <location>
            <begin position="498"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552967.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="65232" checksum="0AD5F050E7A87243" modified="2020-12-02" version="1">MESFIEERINTNTISFWDPVPSLKVRTFSSISKKVQVKATNEKLVTVSADRDLFGRLLIAANARKINLKEVLCYELSPIPCALAYNDGSLRKTTKSVLMTILEKEINIRPRLPPSVLQTTYIIDGMALVQMAKSGGASTFGDLSQKYFSIFTAPLYLHSCNCTEVHIVFDQYLEVSIKAGERSKRGASTALEVQIGGPSTPVPKQWGKYITNQQNKINLCDFLTHSLCKLGQEMLPFNKKMVIGGGFKDGKRCVQITRGCCREITDLKSDHEEADTRLLLHAKYVSQAERRVVIQSPDTDVLVIGVAHFRRLSCEELWFRTGVKDKTRFIPVHDLYQALGSDICKTLPALHALTGCDSNSALVGVGKKKAFEMLKQSNAHQESLSLLGQDPILDETTAGKCEAFICDLXPCSKKAPSTADERRYLIFCQKKQKNEQLPPTSDSLQQHIQRANYQACVWRRSLTAMQSLPQPEGHGWKMEDGVLQPVLMTKEPAPKCLLALTTCHCKKSECLTNCSCNNTGLACTEACDCMADESACKNPNGLFCQYSSDSDESDSDKSDSDESDSDDSDSEESDSDDSDSDESASDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKS4</accession>
    <name>A0A6P8HKS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Melanopsin-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116293666</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556984.1">
        <property type="nucleotide sequence ID" value="XM_031701124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKS4"/>
    <dbReference type="FunCoup" id="A0A6P8HKS4">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="GeneID" id="116293666"/>
    <dbReference type="KEGG" id="aten:116293666"/>
    <dbReference type="InParanoid" id="A0A6P8HKS4"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031556984.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36503" checksum="9F2D2E5DE5CD6061" modified="2020-12-02" version="1">MVSLVMLVALGIISIFAMMVNLLVCFLVYKNKSMRNYTNSFVVSLAVSDILMSFVMFCQYLIGFKNRIIINIAYAVVMFSGVSNLCAVTYDRYIAVTRPLRYMNIMHSHCRKLLFSVWTTSIVISVLPVTWHDKDKKRDGHMIYVMLVQILFIIVPFTFIIISHCFIFYHAKKCSGKCRRLSNANQRRPSLWRSTTEIKVARVFALVAFMFLLSWFPVIYYTSAAIFDRGKMVPRILLEISPITLALGCIINPIIYSLIKPDFRKTLKKLLTTNEHSRRGTGDSSASDATSSFRIIQRNGFSFVRGNSVKKKESLETGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKU9</accession>
    <name>A0A6P8HKU9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho guanine nucleotide exchange factor 38-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555528.1">
        <property type="nucleotide sequence ID" value="XM_031699668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKU9"/>
    <dbReference type="GeneID" id="116292369"/>
    <dbReference type="KEGG" id="aten:116292369"/>
    <dbReference type="InParanoid" id="A0A6P8HKU9"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="67"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555528.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="30290" checksum="D64867B513CE7229" modified="2020-12-02" version="1">MTIRDLVTGIVQEFHLENYQVRELPGKTLADLNAKASSVENSEIAIEDVERRMSNFELDNIHAIKDPRLRCVKELLYEEEQFFNDLKCVFEVYAEPLKKWGMTRADYKAIFEPLETICNLNVRLSNMLEEAVKKWETSTTLIGGIFTELDILWSTYDDYFQFFRGTRMYLKQKRDYEPEFQAFINLQRGARNTHLEMLLLRPIQHVVDYERILTSLLDKTPADHPDRQDLDHVATNFRRIVRERSEEIVAFENEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNE3</accession>
    <name>A0A6P8HNE3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Melanocyte-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557206.1">
        <property type="nucleotide sequence ID" value="XM_031701346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNE3"/>
    <dbReference type="FunCoup" id="A0A6P8HNE3">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="GeneID" id="116293851"/>
    <dbReference type="KEGG" id="aten:116293851"/>
    <dbReference type="InParanoid" id="A0A6P8HNE3"/>
    <dbReference type="OrthoDB" id="5980567at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557206.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35535" checksum="CA44FE697776E62C" modified="2020-12-02" version="1">MQNNFSRPFVTTPSLKTEFETLHDYHYRNLILMTISINGVLSFVTTILNLMIIVTFAKTPSLREVPSNILILGLAVSDFGVGVVAQPLFCVLKLVQLKGDARLTEAIDTLFICSCYVLTSVSFLTVTAITVDRFLAIKLHLRYNELVTTKRHSIALVLIWIVCSFNIALKDFYKIQIFFNILTAILCSILFLNICLLFKISRIVRSHSLQIQAQERSVEQAIDIPRYKKSVNTIYYVVGAFVLCYVLYIVKMIGLNFVAKTQNMEVFFAMAVTIAMFNSVINPLIYCWRIEEMRLAAKKIIRGICRRGEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPP2</accession>
    <name>A0A6P8HPP2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding protein RFX2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116294821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558344.1">
        <property type="nucleotide sequence ID" value="XM_031702484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPP2"/>
    <dbReference type="FunCoup" id="A0A6P8HPP2">
        <property type="interactions" value="2880"/>
    </dbReference>
    <dbReference type="GeneID" id="116294821"/>
    <dbReference type="KEGG" id="aten:116294821"/>
    <dbReference type="InParanoid" id="A0A6P8HPP2"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF33">
        <property type="entry name" value="RFX, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="215"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558344.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="83074" checksum="941CD5EACAD588C8" modified="2020-12-02" version="1">MAATAQPTFVTQQGFEQKEVQSSARSSGNVTQAEFTSTSLPHGIVVTPSTISHSVAQHPSLPQTTVTLAVQAPQIQQNQSLQQTGTAQIIAASVISPEEFQASAAISKEGFSTGDVQYVEATAEHALYPNGAGSNAFHYNDNTMFTQQASATAYMDAAAQPQQAQTFSAVHSAVTPTVVTAANAAPATYAQVAGQQAQSIARHPIAHTTRASPATVQWLLENYETADGVSLPRSTLYNHYLTHCQTHKLDPVNAASFGKLIRSVFLGLRTRRLGTRGNSKYHYYGIRIKPNSPLNALADDSQVALRQSPSTQKRLKPARLDGSEGPDGYSSSAGGSVDPAQQSQHHQHQQYLGDVTQGLPDFEDLDTKGAPLPDNIHEEDLDTFQDMYREHCEAFLDVVVNLQFAVVESLWQSFWRHTSESGEKKTEEEGGQVLSTSPQIRELGDDEDNEKRLPKSKLMILCEYEPVIAYVKSCDHLLYQTLVEILIPEVLRPIPSSLTQAIRNFAKRLEGWVVGSLNHVPKKMGTVKVSTCCAFAQTLRRYTSLNHLAQAARAVLQNPSQINQMLSDLNRVDFANVQEQAAWVCQCDDHLVYRIEQDFKLTLQQQNSLEQWATWLEGVVDQFLKPQEGSDGYPKAAKQFLLKWSFYSSMIIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHKVSKAIGASPISVMGEYVGLGSALAMGLDAVENSLLGNQNGENEANLGDLMVPTVPSSQPESTEPESKRARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ85</accession>
    <name>A0A6P8HQ85_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein odr-4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116294970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODR-4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558529.1">
        <property type="nucleotide sequence ID" value="XM_031702669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ85"/>
    <dbReference type="FunCoup" id="A0A6P8HQ85">
        <property type="interactions" value="1467"/>
    </dbReference>
    <dbReference type="GeneID" id="116294970"/>
    <dbReference type="KEGG" id="aten:116294970"/>
    <dbReference type="InParanoid" id="A0A6P8HQ85"/>
    <dbReference type="OrthoDB" id="21458at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029454">
        <property type="entry name" value="ODR-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33966">
        <property type="entry name" value="PROTEIN ODR-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33966:SF1">
        <property type="entry name" value="PROTEIN ODR-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14778">
        <property type="entry name" value="ODR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558529.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51679" checksum="278220092D21CC4D" modified="2020-12-02" version="1">MGKTVIAEESVSDYVSSLFGTQTWRTGLILGQMGTQKYHVVHLTRTPEQTNSEGSEEDAAPSKVKPSSPDKIDESWFIEHARQVSRMLVGGLDIIGIFIFGPPDMLSKAQTKVRQLLYSLYKATYLRFSAFFDPEDLVHTRVILQICSKTKKVTCRTLDMSDNKSTAQPAEYKYQSFLSRWNTLDTKISLDYKFNVPVKMEKADLNTKIMEGLQSYLQDISSSVCTINGQLPPDDQLLVPSDKQTKSSQLGSCMTVDVYLNKPFLKESKKPKESKSCGVIQVVGSFHCTACLNQKITNREAIQAIKYDIIRSVISRCEVLCDDIVDAQEDNSPESSIENIWTCPRRVFVPLGKTPVRFCDYVFQDETMQDSLDRISELLDMNPREDEVQSLETMTTNQNLEEIKEHLQSRQEMERDSSEEQSDSSTKTSSVSARILGVVLGLATAVIATGVAFIWGEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR72</accession>
    <name>A0A6P8HR72_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292086 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555182.1">
        <property type="nucleotide sequence ID" value="XM_031699322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR72"/>
    <dbReference type="GeneID" id="116292086"/>
    <dbReference type="KEGG" id="aten:116292086"/>
    <dbReference type="InParanoid" id="A0A6P8HR72"/>
    <dbReference type="OrthoDB" id="10042983at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08536">
        <property type="entry name" value="SAM_PNT-Mae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000061">
        <property type="entry name" value="Ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="1">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555182.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="22095" checksum="DFA9F9963C55DC00" modified="2020-12-02" version="1">MYARQDYQVFNNQYPTNGYFHSYENGIQYTQDTAVPPWTTQSQPLQHKMVYPTETYSQTNTNSRLDPTIAFPVALRPSAFEHSRFIDKMQPVHTRVKKEKYIESPHHEEHFPAADPRLWTREDVARWLRWMSEAYSLDNVKPDRFEMNGKGLCLMTMDMFVYRVPEGGKLLYTDFQRRLRLAVGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR96</accession>
    <name>A0A6P8HR96_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555155.1">
        <property type="nucleotide sequence ID" value="XM_031699295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR96"/>
    <dbReference type="GeneID" id="116292056"/>
    <dbReference type="KEGG" id="aten:116292056"/>
    <dbReference type="InParanoid" id="A0A6P8HR96"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="168"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555155.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36799" checksum="6C3BEA994865F28E" modified="2020-12-02" version="1">MAPYDQFAIVLDDEDTFYHPGDEVKGRIFLKLSKSMMIVRIVVGFHGEGRVKYNDEYFIQPYFHDHAVVYDCNNENVHHQLQGSFPPGDFWFPFAFRLPPVKIQSSYLDLTGAVCYWLDAVIERSIWPNEETTIPIFVLELVDVNSPEVQRPRIKQKEMPISCCFVKGGKVNISGKINKGGYYPGDVIECKFFIENESNREVTYTEAIFKQKVTQQYPRRIFFVKHETAMEIASSRGIGKKMIAHVKGECVYAANIEIPIKIGFISSASIGSILSREVILAFALLVNSQMKQERQSAREGQEMGAGNHVHHDDQQMLLTPGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRV3</accession>
    <name>A0A6P8HRV3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transforming growth factor-beta-induced protein ig-h3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557858.1">
        <property type="nucleotide sequence ID" value="XM_031701998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRV3"/>
    <dbReference type="GeneID" id="116294399"/>
    <dbReference type="KEGG" id="aten:116294399"/>
    <dbReference type="InParanoid" id="A0A6P8HRV3"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="263"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="393"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="530"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557858.1"/>
        </source>
    </evidence>
    <sequence length="700" mass="79544" checksum="F68B17FB060F25B4" modified="2020-12-02" version="1">MAHCSLVRGLAVLIILFLCIGGGLGTWWNPFGWRRVWKDWVYEQHRLSHRLDEVSKKVQQPPLQKDGINVCGVKVPITVSRECRTMFGRRRLKCRFRRYYITKYECCPAFARVEGQPGCPKELYVSKLNIIDIAKKLGLNQFVKLVTESGVGSELILDTRYTAFIPSNEAFEAIPKETLDELQGESTRLGDALLFHVLPGKLVTDQLKNNELLKTMDAPHKMRVNRCNDRKIFVVQGAKIIDANQGASNGIVHVIDKFIQPTQGTLRDYLKGKPEFSILSRLLRSHDLEDLTNVTLFAPTDKAFQALPADRLNRLLSKKDCVQKLLKYHVLDEPIYSQLLVSSRQKSMNGLFLDVEHKGNETLKVNDANIITADVTTDDAIVQVIDKLLMSIAAMELVEAVKALNLTKFSSLLERSSLMEELRNGEKNYTVFAPTDEAFEALPSDVKTEITANPQALDKALMYHMIDRKVWTYEFGRDNCVMTRSGMRVRLNTFQFGKVNAANDACIEKANLETCNGVIHVIGKVLVPAKNTIYDVINSKPQFSILARIIQRSTSIMPILAKINGSVTLFAPTDRAFERLRERSPSILKLLQEDSKEATHFLKAHLLDRTIYSCGLQCKYSYWSQFRSSFVVFSMSRDVLRLKLPWRRGASVNNIMLNPVDVAASNGVVHGIEKVMNWSPLGLRTRKYYNPVIFDWWIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRX2</accession>
    <name>A0A6P8HRX2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein 7B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559134.1">
        <property type="nucleotide sequence ID" value="XM_031703274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295458"/>
    <dbReference type="KEGG" id="aten:116295458"/>
    <dbReference type="InParanoid" id="A0A6P8HRX2"/>
    <dbReference type="OrthoDB" id="5985611at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="76"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559134.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30443" checksum="F34A5347CA629D67" modified="2020-12-02" version="1">MEVQSCVMFAIAVILLTVLFKKQIIKWITSVRIYKRLFALLYHQWDKYPTPSKKIRQKLLVQVVEKLTEIGGDVMEVGIGSGRNLEFMRLPTGSSLIAVDYNPDMEGLLREGMTKFPQNNIHLKKFIVEDAANMKSIDDNSVSVVLATQLHCSLDEESIRKAMAEIKRVLKEGGCYFFLEHVLDEPGTLRRFVQKLLYSVIIFLPLLGGGCRCDRETWKYLHQTGFREVSFQRCQEDXFFFWSAPVLSVLRYMSRSKIVGFAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSU3</accession>
    <name>A0A6P8HSU3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116294945</name>
        <name evidence="17" type="synonym">LOC116295859</name>
        <name evidence="18" type="synonym">LOC116298717</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16 17 18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558501.1">
        <property type="nucleotide sequence ID" value="XM_031702641.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559676.1">
        <property type="nucleotide sequence ID" value="XM_031703816.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563115.1">
        <property type="nucleotide sequence ID" value="XM_031707255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSU3"/>
    <dbReference type="GeneID" id="116294945"/>
    <dbReference type="KEGG" id="aten:116294945"/>
    <dbReference type="KEGG" id="aten:116295859"/>
    <dbReference type="KEGG" id="aten:116298717"/>
    <dbReference type="OrthoDB" id="5979213at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031558501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031559676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031563115.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13608" checksum="92EB8C58603636F8" modified="2020-12-02" version="1">MPPKPVVGKKGEKKAGKKAALGDKKKRRSKRKESYAIYIYKVMKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASRLAHYNKKSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSV4</accession>
    <name>A0A6P8HSV4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM135A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM135 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559474.1">
        <property type="nucleotide sequence ID" value="XM_031703614.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HSV4">
        <property type="interactions" value="1043"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116295708"/>
    <dbReference type="InParanoid" id="A0A6P8HSV4"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022122">
        <property type="entry name" value="DUF3657"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12394">
        <property type="entry name" value="DUF3657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="935"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="5">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559474.1"/>
        </source>
    </evidence>
    <sequence length="1291" mass="142746" checksum="D5B6C528E918B15F" modified="2020-12-02" version="1">MSGDLQATLEISVEFSTFHNVDLFQRGYYQIRCSLKPPEKSVSCVDVEYRITNGDYQSDDCLFPALVTPTGLAAVSKTFQILYRNEDIQINDAFIFTLSMLVDSNKVTEQIDQADIQLLVELYFSDSEVGLDSPEALQSVTSQALKLHLSCVKGLHHHVPVLFDYFHFGVIDTTIHAVLTKLSLPDPSILKPVKSSWFSKIPSNARLSTPLFYSKLFGSKPPNNVLNSKTPAEERQIRFAYDTHRSLCSTLLSAQVNLLAHFQFLSEFLPASQQIQIESLDFGERIENLTEGIESIQNANEVFSKICCDLDNISSEIALVWSQFMESFTLNKRVLPFLQEEHHRQRIGHFTEAFFLQEFTWEELQNSQEQSFQLHQSLGQGIKSSRYYQSIPPVVVECPALDGDHSSMPIIFEDKYSHKEPDQAEASNKANLEDIDVTFGPENGDLGDDEMVIINADFNDARPSSDAPNSALALGAVVCNGKDSXVRPVKETMILDDDEDEDXDDDDTTRLCKAIEQLNERKERNHSLDLQFAIDNQTLVTSFKEEASYPKDSSSKDLQNNSDKNTNLNEDKEXQSSKPEDEKEINDKEKDVPEKCYENDDGKELVNKESSELNDTNQVVSSLNGNNEXPXKENELESAEVNNLENGNKCLEQNNDSEKIEENEILENMASSLKAELSKEDGDLGKEGDACQESLEEAFLDEVEKIMESTVEKSEEDSSESVEVNIEEGKDTEETSTAKVEEDASKDDKTVEESRDVGTESCKEQKIGNTNLDSSEKRGTEEGSASNVETSTADANDGVADPVTTSEEMQSLTEDSEKGDSSGGXDASVSNMSSDTVTCDDNASLVNKDCAPLGEISSTDNDKVSKENNVEEGKECQGSEEGEGATSTAEKSSDAEATCQLDVVVMNDEDKVEKELDTGKDVCVTDTSNIKVDQEDGVKTSNVELSTVEKTSSTVKVDKVGEDNDKETGDTAHNLSTSTVTFASALESLSDVSYTKQPSISSQNSQVTDSPSESSVYDTPTSSETAISASDSQADTSGSSVPSKTRKQASKDKTDDKKGKKKTQPKGLSGSSFVSCLPVGNCAGTTSPSFTRCNSVYGGSTRSRFELAKKFMKRQLKFTHQIYSDIGVQAEREPYFTKERPDGIESHLIICVHGLDGNSGDLRLVRCYLEMSLPSSRMDFLMSEVNQADTFVSFEELTERLVQEIRHYIDAYSIFPSKISFVGHSLGNIIIRSALTHPDMRPFLDKLHTLLSLSGPHVGMLYPTSPLVSTGLWLMQKWKKSEALTQLSLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTL7</accession>
    <name>A0A6P8HTL7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase family AAA domain-containing protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558761.1">
        <property type="nucleotide sequence ID" value="XM_031702901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295146"/>
    <dbReference type="KEGG" id="aten:116295146"/>
    <dbReference type="InParanoid" id="A0A6P8HTL7"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061860">
        <property type="term" value="F:DNA clamp unloader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558761.1"/>
        </source>
    </evidence>
    <sequence length="1898" mass="213254" checksum="3009BE466AD81314" modified="2020-12-02" version="1">MSVNMLGVADGEQEMDERKEVDILVKSPESSKIKKSSPSIKSFFLPKESLKINDEPANKKDIKNFFVQQNKSFTDEKTADIELIQHSDSDENVVTESEKVAEGIASRIDAVECRATESAANTKIREECGNISSKKPKPKWSLLWRVAKKSKKSKDNDSDSDSEDFVELSKDEEESKNGCNKLKSRKNKTEQNEDNSCNDEKEKGTEFKDDKKREKEERKKKRKKDRELGEISVGNVKSVEVNEENTVEGEQGLSKMSKEVIVEKEDMIELTVISERKIESKPHSISSDSQTKAAKNAFDVLMNQSRSPIADENEKSEESDMIEDVYSPTRTKEQKSKDQLIDCSPKSSPLELPGNAFDVLMTKNKTNVTSSNLKKSPQKSKTTSSKFKLNIRYSKPLEFEDAVDIGDDGDDDGNSVAYQTEPQASDGSTKKNKKAVPSDTTATTKKLKETSDEVKARGKKKRQSQTCPEIEQSHTKLSIKNAKQDVMDITYISKETLEKLVEEPRKMTKVKKKKNDKTKESKSESIAVIEVQEDSNSSVQEIPPSDVAGGTPKTRSHCSNSEIISPGSDDFEVMPTRTGLRKRNPKNYSSSNEPGSILVEDKKKNKKNEKKEGKYPGKDPGSPEVELVLACKSTKQEKEPKNTEPKNLASIFLKKPKTIEKKEATIDQTTSIKTTQPKDDGNSKLLDEVELKAANMAFNALFASCRTTKATAPAVQLCQQPAPWPHVSHVTQKDDQSDEVFWKLSDSKIKTLPWKPESIQAIPKLKTKAIQLGEFTSSLNRNKSSEESQKVIQNVSPSDCLSTAAVKKVLSEVASCFPGVPIKRLYKQYKNKEEKKEVENLTQTSKDQKEELILGNDEKDCLRNAEERLQKHRGRSKRKKSIESDDELSEKQQKKVPRTKEKDEKKRKEKAKEVENKNDSSKRLRKKEGQGEEEEVLNKKNTKRKSSRLQKRSEDDKSQEESKNEEKTAESSKRKKRKTMDEDDNPKQVVEENEKAEDSRSSLDDKNNSDKKELLWTEKYQPECSSDVMGNASSVSRLRSWLEAWKIKREKTLRKELEMQKRLLAKQKNKDANEKKLAWWDDDQDSDFHLSDEDSDDSGNEESGMCNAMLVLGPKGAGKTAAVYACAKELGYKVFEVNCSSKRSNKQILSRLEEATQSHLVITNPSANTPKASAFGGLFVNLPEKPVNPSPMSNFFKQSNENQQQKHSKNQQNQKGAQEKSEKEKERKLKGNKKGEKGKNPAQVLGGASDSDLIPALSLKAASLILFEEVDVIFEKDKGFWSAVTSFMRNAKCPIIMTSNDSRVDCDGRYEQLTIRSPSINLLSAHLLVTALANEVLVNPSELKTLASWYQCDIRKCFLALQFWILSGGGVKISWEEFLRVHKNRKHLSDVQDNSEIKTDVERNFQNPSKAGELNQCIVEQPLGLDDPREESLFLTIDDWETLAKQRGQALRCGHNSAASASDFQNKDSDFEPTKSSSHPPTDENTHTDSILDTNEPGDSQSMQLADNENKKVTMPDVHCLLMEHVLGLTNSTYGYANGCMELLKDDSISSDKDYLFKTRCGLTYDTQKIGINLVSNNLPTLLPCLHSRCSSNFRPVTMATKETTDIGNVNSIFSDKSIFDDGMSKTPKKKGQEENIVGKNTAATICSELANKDSVDVPSEPDAVAMTTDKSGDVGVTTQEKDRKTKKDSVKEFQGEALEMFSRLAEDISFMDAYIPSITTDGRNDHTAAFGWWQAHVQAGLSDDVITVRKRHDWLTCDTSACIRGALEVASLENSYTSYKSLTEKKQSEEDVDRYLPSMERNSVLNLTGLNEIQSSKLSSKNKLYKSVSSSLPLVTHCTHHVVSMDYLPTLRSICHTERLREQANTKRRFLHYLDSNSLSISKTSQQSLADAFLAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTV6</accession>
    <name>A0A6P8HTV6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein B-H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556125.1">
        <property type="nucleotide sequence ID" value="XM_031700265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTV6"/>
    <dbReference type="FunCoup" id="A0A6P8HTV6">
        <property type="interactions" value="738"/>
    </dbReference>
    <dbReference type="GeneID" id="116292918"/>
    <dbReference type="KEGG" id="aten:116292918"/>
    <dbReference type="InParanoid" id="A0A6P8HTV6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556125.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23240" checksum="1E332E115F0090A4" modified="2020-12-02" version="1">MRGMDSVNNASFSIDALLGAQQQVEGTTRKQTQSVHSSLSPSAGMKNTTSDMGFHDDYSEKEVSPSKHLSLEKRERLSTKKRRKRTAFTSFQLKCLEDKFKFSKYLTIAERDMMARSLQLTNRQIKTWFQNRRTKWKRENVGEALQLNYEIQRTATLRCSPPWLQVCPYPPVFSTMDPSCSWSAPPYLLQTTAARFPCNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU47</accession>
    <name>A0A6P8HU47_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559919.1">
        <property type="nucleotide sequence ID" value="XM_031704059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU47"/>
    <dbReference type="GeneID" id="116296102"/>
    <dbReference type="KEGG" id="aten:116296102"/>
    <dbReference type="InParanoid" id="A0A6P8HU47"/>
    <dbReference type="OrthoDB" id="10373762at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559919.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28178" checksum="10693471944F8D95" modified="2020-12-02" version="1">MKQMRAMLDSHDQESENARHRISMLLLERDTARKNFDRAVRDVGDSNAELRRVGAQLEASVMQERRLNTEIIVKEEQLRQREQAIEDLERQIQTQREIIDDQTRTEGEREAARAQVGSLEERIAELQAQREGLERELGLTTRQKILRGLLKYGVPLAFAVTLAGAIAGIMNAINGVASGAKALGKKVGKEMGEMGKKLGNGLIALGKTMAASIPGLLGSVLSLTLKAGGELLKFVGNNIWILVVAIGVVFLKKMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUK8</accession>
    <name>A0A6P8HUK8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116293108</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556365.1">
        <property type="nucleotide sequence ID" value="XM_031700505.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUK8">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="GeneID" id="116293108"/>
    <dbReference type="KEGG" id="aten:116293108"/>
    <dbReference type="InParanoid" id="A0A6P8HUK8"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF191">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028462007" description="Sodium/hydrogen exchanger" evidence="14">
        <location>
            <begin position="22"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="97"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031556365.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="65487" checksum="CDC9CC54ECC509F6" modified="2020-12-02" version="1">MKKSWQGILALCFVIFLRSSATDDGNNVPTSSPTVAPXTRNNSSQTNVTTPSVNITTTPLPTKPPSTEPPEEKVEPPEVEQHSSLTIFFILLVIALCILVIHFLIKTKFHYLPESVAVVFLGALIGLVIKALQHFALGDWQREEHFNPTAFFLILLPPIIFESGYSLHKGNFFSNIGSIIIYAVFGTAVSALVIGGGIYLLGKGGVAFQLGLRESFAFGSLISAVDPVATLAIFHALDCDPTLNMLVFGESILNDAVSIVMTNTILSLGGPKYASMSSFEAFFSAIVNFMVMFAGSAAIGIAFALFSALLLKHVDLRSTPSLELATMLIFSYAPYGLAEGLQLSGIMAILFCGICMSHYTHFNLSPMTQITVQQIFRTAAFMAETCVFAYLGMAIFSFKHQFKPAFVIWSIILCLLGRAVNIYPLSALVNQFRDTKIDRKTQFIMFFSGLRGAVAFALVLHLRLDDEKRHVLITSTLIIVLFTILFLGGSTLPLLKFLKAENTAASGLTMSKTETEGTALDADKLTDDEWRIQRKALKGFTKLDAKYFLPFFTRKFTRQEVRESHNEMQRLTSQLYNEVYSRPNSEDESENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVJ7</accession>
    <name>A0A6P8HVJ7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031556670.1">
        <property type="nucleotide sequence ID" value="XM_031700810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVJ7"/>
    <dbReference type="FunCoup" id="A0A6P8HVJ7">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="GeneID" id="116293386"/>
    <dbReference type="KEGG" id="aten:116293386"/>
    <dbReference type="InParanoid" id="A0A6P8HVJ7"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000035">
        <property type="entry name" value="Putative lipoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010925">
        <property type="entry name" value="PRK14345.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556670.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25842" checksum="094D21BC9C7E2AD4" modified="2020-12-02" version="1">MVRNLGRIAYLDALRIQKTLARHHLDFKKDKSSIRPRNVLFICEHNPVYTIGIRNKTFGEEEKNKLKKLGAEFYTTDRGGLITFHGPGQLVCYPVLDLGDFKKSIRWYVRSLEDVLIDTCARYDVEAGVTDDTGVWVEDRKIAAIGVQASRWVTTHGVALNCNTDLTWFDHIVPCGIVGKGVTSLSFESKSEININDATTHFLASFSDVFNCQLRHFQELSNESILVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX20</accession>
    <name>A0A6P8HX20_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557122.1">
        <property type="nucleotide sequence ID" value="XM_031701262.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HX20">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="GeneID" id="116293789"/>
    <dbReference type="KEGG" id="aten:116293789"/>
    <dbReference type="InParanoid" id="A0A6P8HX20"/>
    <dbReference type="OrthoDB" id="5980584at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557122.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12208" checksum="545BA76F71B99A28" modified="2020-12-02" version="1">MSSNYARKMALLQARIFGKLTRPVTKQXVKSFELLFVRRPLGEVINSYYPPLKMFNSLLLRLRHLGFYRDDHLDYREEMAVRRKERGKGPPKKGEGKRSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX85</accession>
    <name>A0A6P8HX85_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557197.1">
        <property type="nucleotide sequence ID" value="XM_031701337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX85"/>
    <dbReference type="GeneID" id="116293848"/>
    <dbReference type="KEGG" id="aten:116293848"/>
    <dbReference type="InParanoid" id="A0A6P8HX85"/>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF534">
        <property type="entry name" value="TETRASPANIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557197.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26222" checksum="8670FE116D3BFE7E" modified="2020-12-02" version="1">MCGVKCSKYLLFVFNFFFLLSGLAVLGIGIWTKIDAGQFDSFLGTSGYAISANILIAAGAFVVIVAFLGCCGAVRENRCMLGTFFAVLLLIFCAEAVAGILGFIYRDQVEKEISTEITKQIKNEYGFSSTIDYNVNILQQRLKCCGAKNREDYKESRWRKELNPNKLVPLSCCIENANKTSCYKDSSYDQVYEKGCISELKTFADNHMVLIGAIAAGISGIQLFGMVFACCLFCSIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXK3</accession>
    <name>A0A6P8HXK3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase RGLG5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557322.1">
        <property type="nucleotide sequence ID" value="XM_031701462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXK3"/>
    <dbReference type="GeneID" id="116293960"/>
    <dbReference type="KEGG" id="aten:116293960"/>
    <dbReference type="InParanoid" id="A0A6P8HXK3"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052079">
        <property type="entry name" value="E3_ligase/Copine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751">
        <property type="entry name" value="COPINE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45751:SF53">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="83"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557322.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36277" checksum="A6E5D1814477396A" modified="2020-12-02" version="1">MLRFPWDVIVFFSTAVVGFLLYVVFTRPREAYKGYKKISRTFKDSSLSIALGLKEDFHAIQDKFFSVLEVSKAIKTAGLETSNLIIGVDFTASNEWQGRKSFHGRSLHHIFKNSSKKLNSYQTVIKTIGKTLEPFDEDNLIPVYGFGDVKTKDQSVFNFNSNDQPCKGLDSVLEAYNEVVRKVSLSGPTSFAPIIEKAIEIVSKDRTYYILVIIADGQVVEDQDLKTREAIVKASNYPISILVVGVGDGPWDRMHEYDELLSERKFDNFQFIEFNDIVANAKYPDAAFALHALMEIPDQYQAIKNLGLLREISENKQNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY78</accession>
    <name>A0A6P8HY78_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC116294159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116294159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557567.1">
        <property type="nucleotide sequence ID" value="XM_031701707.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557574.1">
        <property type="nucleotide sequence ID" value="XM_031701714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HY78"/>
    <dbReference type="GeneID" id="116294159"/>
    <dbReference type="KEGG" id="aten:116294159"/>
    <dbReference type="OrthoDB" id="6241117at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.670">
        <property type="entry name" value="GCM domain, large subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3530">
        <property type="entry name" value="GCM motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039791">
        <property type="entry name" value="GCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036115">
        <property type="entry name" value="GCM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043020">
        <property type="entry name" value="GCM_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043021">
        <property type="entry name" value="GCM_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003902">
        <property type="entry name" value="Tscrpt_reg_GCM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12414">
        <property type="entry name" value="GLIAL CELLS MISSING RELATED/GLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12414:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR GLIAL CELLS MISSING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03615">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90073">
        <property type="entry name" value="GCM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50807">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GCM" evidence="7">
        <location>
            <begin position="127"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557574.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="80676" checksum="FF49B79E1C082BC5" modified="2020-12-02" version="1">MEDTETVITIKEEQPSTDNEENNEEQATEKPKTPELESSKPIHINGGEILNKFNHALASIITTSDRLSNNDDSSNTIVTSLPPLIHKSARLVSSIWFPDNSVRSPIYHSSYDYPCIHERSVDAALGHAQIQEAGSSQQPVEEYDEFNEWVDGSCKFRYSLYSREAQAHISGWAMKYTNNHNKYVLKKTCVGVLLCSKDCTLPNGLKIVVRPAISDKVRERQIGQSCPNASCNGVLSHRKCTGNNGYPVTHFWVHQDDGIYFESKGTHDHFRPQARRATPDRNHNRGRTLSPKQEGTSLEETENAENKESKPAKSTETSKRGRKRKLHQDHQLSLSKILTTHSAINHTLRTEVLRGFSMEEEEQYVCVTLPESEHLIQRAVLSHDQSSIASYGRLYLLCQTFIDIVPGFNLLETRMISHEVVGWPVVMATLYRQGTREGIVQHMKTLARLCSSPREEIFSPKWQMVIHDFTPEQAQLAIEAIVNMIINSQVQTLLRVFQYKSVSSLYKMLREKVTSSIQGFHSHFELCKREIISRLQDPVMTMKFCETMKRLTDENCTVQEYLSADCMLSGCALGSVIREFWNFWGSPLVGCKVFPVASSIGAYQERIEIWRKSFLEVEWCDNPRDVTLQNLSDVVFRWIKCQKDFWPKTAYQDCRVMDFTAVRPPLFDDRRLHFVRHGERLGSAFHRPISYRAFYMPRMHWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ46</accession>
    <name>A0A6P8HZ46_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116294474</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557935.1">
        <property type="nucleotide sequence ID" value="XM_031702075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294474"/>
    <dbReference type="KEGG" id="aten:116294474"/>
    <dbReference type="InParanoid" id="A0A6P8HZ46"/>
    <dbReference type="OrthoDB" id="5979389at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF348">
        <property type="entry name" value="SYNAPTOTAGMIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557935.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32669" checksum="2350DE762FC70661" modified="2020-12-02" version="1">MKAFVVDVVAVFICIFLCCILFSLYAMYKRQKLKNNQILQLPLPSELRKNRVPVIESTPFWVPSYIGHMVDIQVQPSLDNLGPKFSTPKPKRKKVSEQIENPQLKFSVKYIARSYRSALMVELLESKHLGKGNLVHDVYLEESVPEASFLSETGVFSAVELSPTVHKDXRKQVVRRTRKNSYEFEMSYEDLQLQCLQFSVMAFDEYSRQKVIGDVILPMADLTSQGLDVTRELIMWREIQTMEKKASMSXEQRDENQNLIEARIDEIGDKPAPSESTSRRCSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZQ6</accession>
    <name>A0A6P8HZQ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ring canal kelch protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560771.1">
        <property type="nucleotide sequence ID" value="XM_031704911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZQ6"/>
    <dbReference type="GeneID" id="116296813"/>
    <dbReference type="KEGG" id="aten:116296813"/>
    <dbReference type="InParanoid" id="A0A6P8HZQ6"/>
    <dbReference type="OrthoDB" id="409824at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560771.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="32641" checksum="771210ACA6B96257" modified="2020-12-02" version="1">MAAPCESEPDFSQPWKVSDIVLLVDDVRLHVHSGVLVMWSPVFENMFAELKRKNARVLTLEKQKPNEIRELLLVIYPTIKRPINENNCYYLLEIAEQFQMRKVTEQCEEYLMRTLKSGSELVDLLVLASKYNMRILREECLKLTKQLEWKVIQQHNLYEQIELKDYREIAEERLRSLHNDHQSEKEKAFRLEEELDYYRRQGELARTPSSCVVNPGLASPRLPRKQIVQPCKSRPVQVVLNTRIKPAVQSPEKSPHVPPPVPKRAHFPVKPQPIIKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZU6</accession>
    <name>A0A6P8HZU6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116297742</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116297742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561889.1">
        <property type="nucleotide sequence ID" value="XM_031706029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297742"/>
    <dbReference type="KEGG" id="aten:116297742"/>
    <dbReference type="InParanoid" id="A0A6P8HZU6"/>
    <dbReference type="OrthoDB" id="5978510at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031561889.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26666" checksum="176C92E5DAA5CCDC" modified="2020-12-02" version="1">MGNVNKRQKRESLLNKAKVMYAEKLLVDHNVNSQGNVKSGVHESVTSTDPLLRGWALRLTRKKSRFTAKQKEYLDXKFESGAKTGKKYNPLQVSLEMRTARDNEGKCIFSVDEFLSEDQIKGYFSRISSKRKRDNVSDESERKQASAVAEEMMLQDMHHLVDRNIQISHPIIIDNYNVCDLVKKDRLNKLSIPLLKNLCEKLDVNLIKVGSGKRKGPYIALLKKLVATCSCSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0D5</accession>
    <name>A0A6P8I0D5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP synthase subunit g, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116297156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561183.1">
        <property type="nucleotide sequence ID" value="XM_031705323.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I0D5">
        <property type="interactions" value="1004"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116297156"/>
    <dbReference type="InParanoid" id="A0A6P8I0D5"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="unsure residue" description="I or L" evidence="11">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031561183.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="12593" checksum="A418A72A740B8AF4" modified="2020-12-02" version="1">MAQKLASLGQKIVTRAPVLATKYGFQALASAKKAQPTLEKFWSNARVEMRPPSPSDWPVIKKAFLNLKDATISGRFLNVTVKEGVANTLVAXEIAMWFYVGEIIGRRSIIGYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1A0</accession>
    <name>A0A6P8I1A0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">G-protein coupled receptor 161-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116297444</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561527.1">
        <property type="nucleotide sequence ID" value="XM_031705667.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561528.1">
        <property type="nucleotide sequence ID" value="XM_031705668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1A0"/>
    <dbReference type="GeneID" id="116297444"/>
    <dbReference type="KEGG" id="aten:116297444"/>
    <dbReference type="OrthoDB" id="5980076at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031561528.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49086" checksum="BF089DAFD223355B" modified="2020-12-02" version="1">MDNEQTLKAIQEDYLKLIEHENQRARGQAEKNIESLLMGILFLVSFLANATICTVLLQSNHRQTASNVLLLSLILANLLISVSLIPFNIASVIADEWLFGTTWCETSGFLVNTLFSGSNLSIVAIAIHRYYFVVKPLALKIDVRRAHFIVGFLWFSSLTCAVPPLFGWNSYAYSPGKAHCTLMWKSGGPALFYSIYYSLWCFLIPLLIILFVYKSIYNKAKKQRKLGTMATGKFPTNGHIPRAASLQSIDNQQLACGCFPKCTSQTQNNNFYMQRNQIVSSVSSTSFSFESSTQSLPGRLNVQQRKEALRRQVSRHSSVIQQRTFQSVSAIVVSFIVCLSPYFFINWWSLFSQSSPHRILDFLTSWLYLIMTAVNPVTYGYSNRQIRRAVKRLPLAKRFFKAHGRGRAYQMDATIYKKPAISQRNEALEHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1B7</accession>
    <name>A0A6P8I1B7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295093 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558670.1">
        <property type="nucleotide sequence ID" value="XM_031702810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1B7"/>
    <dbReference type="GeneID" id="116295093"/>
    <dbReference type="KEGG" id="aten:116295093"/>
    <dbReference type="InParanoid" id="A0A6P8I1B7"/>
    <dbReference type="OrthoDB" id="10320263at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558670.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27514" checksum="756273A6560A9A61" modified="2020-12-02" version="1">MTVRYGVGVTSAHGGSGTNGPLPVAYTYRPIPHNRTDLHIDNNQCELTNTRRSQQVSTVSKNKANLSSFWQYRNITMASANYLSVPMRASRRSSISSTSEDRRAPNFDALRHDVEDIKETIRRLYRQLDSYDEKRLQLNEGLESLKRANKDYELKVRDLLDVFKNPPATINFSSYSSKASNRLGSGLLQSYGSNQSSRSSSRSGTNAAVFDDDYEEDSYYDDYPNERNFTKSVENIDDDSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1P0</accession>
    <name>A0A6P8I1P0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116298216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562459.1">
        <property type="nucleotide sequence ID" value="XM_031706599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1P0"/>
    <dbReference type="FunCoup" id="A0A6P8I1P0">
        <property type="interactions" value="2267"/>
    </dbReference>
    <dbReference type="GeneID" id="116298216"/>
    <dbReference type="KEGG" id="aten:116298216"/>
    <dbReference type="InParanoid" id="A0A6P8I1P0"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031562459.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16043" checksum="28F206F7EF484810" modified="2020-12-02" version="1">MSQARSLPQSKETLLKSYTKRLKDDVKSILDNFTEILKCSKVEDESQVSCVTQVVQDQYECNVRAANIVRAGESLMKLVSDIKEFLILNDFPSVNESISERTTRLSNMQQHTDKQLMNLKEDIAITLYGLEEAFYSSPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I217</accession>
    <name>A0A6P8I217_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mirror-image polydactyly gene 1 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561581.1">
        <property type="nucleotide sequence ID" value="XM_031705721.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I217">
        <property type="interactions" value="782"/>
    </dbReference>
    <dbReference type="GeneID" id="116297493"/>
    <dbReference type="KEGG" id="aten:116297493"/>
    <dbReference type="InParanoid" id="A0A6P8I217"/>
    <dbReference type="OrthoDB" id="6426880at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026175">
        <property type="entry name" value="MIPOL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22089">
        <property type="entry name" value="MIRROR-IMAGE POLYDACTYLY GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22089:SF2">
        <property type="entry name" value="MIRROR-IMAGE POLYDACTYLY GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561581.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="56064" checksum="06423F17A1A294DA" modified="2020-12-02" version="1">MDSIRDELNYFHRTNDSFNRGHHFVSTVDDDREEVDEIRQHVRSAMKEARRKMANLRRDAEEKDKLLTEEQRLRQQLERELSEKSEELLREKSRSLMKDGRGSQEPRYSSPLHFSLDYSGSSLLNSGELEASRSLNSQLTEKLANAEAEIQATKMTRDGLLMQAESRIASQGAALVDKIYRAQKERDVAVNARLRQAKEEKEDLLATMRRLEKEQAGFDSGVDSVYDDEDADQVRLRTECSCNCSGLHHAWEILSLNDWKSIKELLNRLTVSESPRSIDKQGTVMADKLKSAQKTHQRAIAEELKTVLEERDQALSKVKALEEEVEKLHKELKMLKNQFKLAEKHRIKTTQAQLLSSQHERDASLRKTKRLEEELETIRVYYSLHRSLSQEQNLRDQFNSTMDGFENRXRMREGELVLAQRSYDDLVSKLRSVSSERSTLAEQVYEINKKYQKEKERADKLERLVGVLRKRINAGAGASVETIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3K2</accession>
    <name>A0A6P8I3K2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC116295652</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116295652</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559400.1">
        <property type="nucleotide sequence ID" value="XM_031703540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295652"/>
    <dbReference type="KEGG" id="aten:116295652"/>
    <dbReference type="InParanoid" id="A0A6P8I3K2"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000202">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051586">
        <property type="entry name" value="PKC-binding_NELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF5">
        <property type="entry name" value="EGF-LIKE CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042">
        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2331"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
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            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
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            <end position="353"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
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            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1245"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1286"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1365"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1405"/>
            <end position="1445"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1446"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1485"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
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            <end position="1566"/>
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    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1568"/>
            <end position="1603"/>
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    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1604"/>
            <end position="1644"/>
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    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1693"/>
            <end position="1733"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1734"/>
            <end position="1775"/>
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    </feature>
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        <location>
            <begin position="1776"/>
            <end position="1816"/>
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    </feature>
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        <location>
            <begin position="1817"/>
            <end position="1856"/>
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        <location>
            <begin position="1896"/>
            <end position="1937"/>
        </location>
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        <location>
            <begin position="1938"/>
            <end position="1978"/>
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    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1979"/>
            <end position="2020"/>
        </location>
    </feature>
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        <location>
            <begin position="2040"/>
            <end position="2290"/>
        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="881"/>
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            <begin position="943"/>
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    </feature>
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    </feature>
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    </feature>
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            <begin position="2359"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1186"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2359"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1572"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1593"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031559400.1"/>
        </source>
    </evidence>
    <sequence length="2382" mass="253291" checksum="671DEF46906F58BF" modified="2020-12-02" version="1">TEKPATTAEEVTGKPTTAEVVTRKRTTTEEVVTGKSSSAEKIGQVTATVVTTTEEKTEQTTTLEKETEMPTTGEKETVQPTTGEAIGLVPTNAEPTTAEKTKLTTTGEKETEMPTTREKETVQPTTGETLGPYQCTCKDEFSGDGRTCTETTAECEPACGDDERCLNIDNKYQCVCKEGFDRRNEVCKDIDECATEIPPCDVHAICTNVPGSFVCRCVRGYNGDGKTCTDIDECTESNVTCGADAVCVNSQGSYYCSCNEGYKDVNGKCTDIDECSSPELNKCPTNARCSNVLGGYLCRCLKGFVGDGRICSDENECEVGKRKCDKNADCINSVGSFNCQCRDGFTGDGITCTEKTTTPTFPEVTTAKPTTAAVVTAKPTTGQVVTGKPTTGQVVTGKPTTGQVVTGKPTTGEVVTGKPTTTGEVETGKPTTAEVVTAKPTTGQVVTGKPTTGQVTTGKPDTTGQVTTGKPDTTGQVVTGKPTTSEVVTGKPTTSEIVTGKPTTGEVVTGKPATTGEVVTGKPTTAEVVTGKPTTXEVVTRKPTTGKVVTGKPTTAEEVTGKPTATDKVVTGKPTTGEVVTGKPTTGEVVTGKPTTSEVVTGKPTTSEVATGKPTTSEVATGKPITSKVVTGKPTTGEVATAKPTTSKVVTGKSTTDEVVTGKPRTGEVVTGKPTTGQVVTGKPSTDEVVTGKPTTGEVVTGKPATTVEVVTGKPTTSEVITGRPTTGEAVTGKPATTGEVVTGKPTTGQVVTGKPTTSEVVTGKTTTGEVVTGKPTTSEVVTGKAITTDEVVTGKPTATDEVETGKPKTTDEVATVKPTTSETVTVTSSTTADLATGKPTTAEGVTVKPTTSEEVVTGKLTTAETIGPVTATVVTTTVEKTKQPTTGEEDTEQPTTEEKIGPVPSTAEPTTGEKVELPTTGEDTEQPTTGEKLVPVTGTVAPTAGEKTEHSTPGTEDTVQPTTGEKETEQPTTGEEETKQPTTIVEITPKTGILTEITQTPRPQIKITTSTVTEDKRTGKPTTGXXVTGKPTTGKVVTVKHTTSEVATGKPTTDQVVTGKPTTTDEVGTGKATTGEVATGKPTTTAEEVTGKPTTDEVVTGRSPTAEVVTGKPATTAESVTAKPTSAEVVTGKKNTTDEVVTGKPTHTAESVTAKPTSAEVVTGKPNTTDEVVTGKPNTTDEVVTGKPTTTAGKPTTGEAVLPVNFCTEGKHDCHPNADCFVHDNGYVCRCKEGFVGNGTQCQDEDECEKLTNNCDENANCMNTLGSFRCSCKDGYSGNGNVCKDINECEGIEKDCHPNATCINTEGSYKCQCKQGFIGDGEVCKVEGVCPQGCDVNADCVLVDDKSQCICRRGYRGNGITCTDIDECTDENDCHPDALCTNTDGSYVCRCMKGYTGNGKTCTDIDECLDDTRVCTSNSLCTNFKGSYMCRCLKGFKRNGETCEDVNECDFDVCGKNALCTNTNGSYVCHCRKGFEGNGQFCTDKDECVLEEHDCSELADCINTEGSFACQCIAGYEGDGRNCTDVNECEKGTHNCNENALCSNNEGSYICQCLPGFIGDGITCVDMMTTCMPECGENAVCQLQEGRPQCVCKQGFQGPNCIDIDECTNRDNDCSPNALCTNIPGSYVCRCLRGFTGDGKKCVAKSGCNFDCGENAKCINASSTDDIIGDEPGVFICKCNDGFEGNGLQCTDINECDKGLHSCHVNALCTNTDGAYVCRCLKGFAGDGRSCIDVDECKTKEYKCNENEVCVNTQGSYKCACANGYKLSDNGTCIDINECRDDSHNCHVNALCTNTVGSHFCRCMRGFFGDGRKCIDVDECSSINNCDINAVCTNTEGSYQCTCKDGFRGDGRTCTEILTPCKPGCAENENCVNVNNVFQCLCKEGYDKKNGKCQDIDECADQILNDCDQKATCNNTGGSFVCKCMTGYIGDGKLCSDKNECFEGEDDCDLNADCVNTEGSYTCNCMKGFTGDGRRCTDVDECKENLDDRCNGNAICINTEGSYACECLPGYEGDGEYCEAEGILGYFNVTHINNNIAIGCGKKEMMIIVRQMFFMGMQREDLNLIDPKCKPKQNGTHFIFSTGLTECGTEMTQTPHAFVYKNVIRERPPNPNSMITRLHDIQVPFRCFYTRRGATSALALEPSRKVIRANASDTGMFALNMAVFKDFSYSVPYPEQDFPIPVMVNRRIYFQLSVQSMDNRLAVTADRCHATPDPNRNNRIQYDLIRNGCPVDRTIIYHKTDLKQVHRFSLKAFQFVNVKDPTYAYIHCTVVVCNVSDANSLCNKDCKIESQARRHRRSVSYSRPVHVDVLSQGPMIKPEPRNTKDLLPSFLAIATTLAIIGFTILIVAVIILRKKTHRQPDQEHQHQHHETGQGKSIAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3X7</accession>
    <name>A0A6P8I3X7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">O-phosphoseryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5 18">2.9.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 18">Selenocysteine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 18">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sep-tRNA:Sec-tRNA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116295732</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 18">Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:25041"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="Rhea" id="RHEA-COMP:9947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78551"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 20">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the SepSecS family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.2" evidence="5 18"/>
    <dbReference type="RefSeq" id="XP_031559500.1">
        <property type="nucleotide sequence ID" value="XM_031703640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3X7"/>
    <dbReference type="FunCoup" id="A0A6P8I3X7">
        <property type="interactions" value="2131"/>
    </dbReference>
    <dbReference type="GeneID" id="116295732"/>
    <dbReference type="KEGG" id="aten:116295732"/>
    <dbReference type="InParanoid" id="A0A6P8I3X7"/>
    <dbReference type="OrthoDB" id="10263545at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098621">
        <property type="term" value="F:O-phosphoseryl-tRNA(Sec) selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001717">
        <property type="term" value="P:conversion of seryl-tRNAsec to selenocys-tRNAsec"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019872">
        <property type="entry name" value="Sec-tRNA_Se_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008829">
        <property type="entry name" value="SepSecS/SepCysS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03531">
        <property type="entry name" value="selenium_SpcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944:SF2">
        <property type="entry name" value="O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944">
        <property type="entry name" value="SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05889">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017689">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10 18 20" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18 20" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0711">Selenium</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 20" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
        <ligandPart>
            <name>tRNA variable arm</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
        <ligandPart>
            <name>tRNA discriminator base</name>
        </ligandPart>
    </feature>
    <feature type="site" description="May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate" evidence="20">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="20">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031559500.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="54877" checksum="81A901153C045231" modified="2020-12-02" version="1">MTMNSTNFGLCARLIPQNYVNQGQNARKTIENEIRVFLEHRKLPSNGWDDSKIEFLLQELSIMDSNNFPGNVGAGEREGRVASALVAKRHFRLSHGIGRSGDITAIQPKAAGSSLLMTLTNSMVLDLIKMTGVKSATSCAVLPLATGMGLVMVLLTLRQQRPEAKYVIWPRIDQKSCFKSMITAGFIPVIIENVLNEDELTTDLAALERKIKELGCEAIACVMTTTSCFAPRVPDRLEEVAKLCKEQDIPHVVNNAYGIQSSKCMHLIQQASRIGRVDAFVQSTDKNFMVPVGGAVIAGFDKSFIDKVCENYPGRASATPSIDMFITLLSLGADGYEKLLKERKEVFSYLSEGLSKVAGQHSERLLKTKHNPISLAISLSHTSTYSSIVEDSRGTTQLGSMLFTRCVSGARVVAPGTTKVINGYEFPNWGSHSNEYPCAYMTAAGAIGMTKDDVDTFLKRLDKCLQKCNARTGNPVVDPELQEKEDPNKTKPVQETVVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4S0</accession>
    <name>A0A6P8I4S0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BET1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116299060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563554.1">
        <property type="nucleotide sequence ID" value="XM_031707694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4S0"/>
    <dbReference type="FunCoup" id="A0A6P8I4S0">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="GeneID" id="116299060"/>
    <dbReference type="KEGG" id="aten:116299060"/>
    <dbReference type="InParanoid" id="A0A6P8I4S0"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031563554.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12704" checksum="2F2DF4141269EDA9" modified="2020-12-02" version="1">MASSHWGNSRGNKNDDKMDKIMESENNRLVDNLSNKVSMLKGIAIDIDRESKQQNKYLGGMGDDFGGAAGLLTGSAQRLSHMIASGKSNRKLMCYIIAGLVFLFVVLYYGLGRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5Y6</accession>
    <name>A0A6P8I5Y6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formin-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560402.1">
        <property type="nucleotide sequence ID" value="XM_031704542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5Y6"/>
    <dbReference type="GeneID" id="116296515"/>
    <dbReference type="KEGG" id="aten:116296515"/>
    <dbReference type="InParanoid" id="A0A6P8I5Y6"/>
    <dbReference type="OrthoDB" id="10558324at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028160261" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560402.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="15602" checksum="90186B70094F5D52" modified="2020-12-02" version="1">MARVAVLLLALVVCVSANPMVKRQACGFGCAPPSCSYGCPTMCCAPPPPPPPPPQMVNHVTHVHHHNIHHQAPMAPAMPAPPMPAPPPAVVQSQQHVWEYVPPPPCAPPCAPAMPMPMPMPVQAPCGGPCAPAANPCAPSCSPICCKKRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I728</accession>
    <name>A0A6P8I728_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BUD31 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116299298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563788.1">
        <property type="nucleotide sequence ID" value="XM_031707928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I728"/>
    <dbReference type="FunCoup" id="A0A6P8I728">
        <property type="interactions" value="2500"/>
    </dbReference>
    <dbReference type="GeneID" id="116299298"/>
    <dbReference type="KEGG" id="aten:116299298"/>
    <dbReference type="InParanoid" id="A0A6P8I728"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563788.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16932" checksum="F7A366F810586127" modified="2020-12-02" version="1">MPKVRRSRKPPPEGWELIEPTLDELDQKMREAETDPHEGKRKVEGLWPIFRIHHQKSRYVYDLYYKRKAISKELYEFCLKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGSNCICRVPKSKLEEGKIVECVICGCRGCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9G0</accession>
    <name>A0A6P8I9G0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297238</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561290.1">
        <property type="nucleotide sequence ID" value="XM_031705430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9G0"/>
    <dbReference type="GeneID" id="116297238"/>
    <dbReference type="KEGG" id="aten:116297238"/>
    <dbReference type="InParanoid" id="A0A6P8I9G0"/>
    <dbReference type="OrthoDB" id="10275278at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027916663" evidence="1">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561290.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16651" checksum="E38A7BA07D163EFD" modified="2020-12-02" version="1">MVNSDRVLAEDFSTLVLICCLIIVAVEGLSNTDSPGNCTTQNSRCCKLGLKAARHHAISPIYTCYYEALIAGLDHQTSVAFRLRASKGRLRQIKNIARATAFRRRLSFCYTGKHKKCFESCCLAKRKNNHSKLKNASHKPTSTTTRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAD9</accession>
    <name>A0A6P8IAD9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116297980</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cell membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562162.1">
        <property type="nucleotide sequence ID" value="XM_031706302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAD9"/>
    <dbReference type="FunCoup" id="A0A6P8IAD9">
        <property type="interactions" value="1717"/>
    </dbReference>
    <dbReference type="GeneID" id="116297980"/>
    <dbReference type="KEGG" id="aten:116297980"/>
    <dbReference type="InParanoid" id="A0A6P8IAD9"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090533">
        <property type="term" value="C:cation-transporting ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 20" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 20" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="904"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1040"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
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        </source>
    </evidence>
    <sequence length="1078" mass="119823" checksum="F3907A9262860D6E" modified="2020-12-02" version="1">MSSKDELAGLYLQEKYDVDGDPEGYGRSNSYRVATTPLTEGDGGDPSKGKSKDGDDAQKKAKKKGKKEKKADLEELKQELEVDWHKITQEELLSRLETNLEKGLTEEEAERRLKRDGPNALTPPPTTPEWVKFVKQLFGGFATLLWIGSVLCFIAQAVLEATIEEAARDNLYLGVVLAFVVIVTGIFSYYQEAKSSKIMDSFKNMVPQEATVLRDGGKHTLDSEKLVVGDVVFVKGGDRLPGDIRIIECKSFKVDNSSLTGESEPQSRGPECTNENPLETKNLAFFSTFALEGNATGIVVQIGDNSVMGRIANLASGLGSGKTPIAVEIEHFIHIITGVAVALGVSFFIIALILKYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDNNIVEADTSEEQKGGEDKKFSETWTSLARIATLCNRAEFKAGQEDKPVLKRECAGDASESALLKYVELAIGNVPSFRKRHPKVCEIPFNSTNKYQVSIHELHTKVEGEKDLPENEKEKDFHHVLVMKGAPERILDRCSTILLDGEEKELDEKMKESFNQAYLDLGGLGERVLGFCQKLLPAEEYPKGFEFEAEEPQNFPLEKLCFVGLMSMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETVEDIAERLNIPVEDVDPRKAKAVVVHGQKLKDYDQDMIDEVLREHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLFFIILDIPLPLGTVTILCIDLGTDMVPAISLAYEEAENDIMKRKPRDPKNDNLVNERLIAMAYGQIGMIQASAGFFTYFVIMGENGFYPRDLFGIRRQWDDRSNNGVVDSYGQEWTFKQRKILEYSCHTAFFVSIVVVQWADLIICKTRRNSIFTQGMKNKMLNFGLLFETLLAAILSYTPGMDKGLNMYPLNWNWWFPAMPFSLVIWIYDEIRRYILRRYPGCWLDRETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAY6</accession>
    <name>A0A6P8IAY6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116300599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031565353.1">
        <property type="nucleotide sequence ID" value="XM_031709493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAY6"/>
    <dbReference type="GeneID" id="116300599"/>
    <dbReference type="KEGG" id="aten:116300599"/>
    <dbReference type="InParanoid" id="A0A6P8IAY6"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="336"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031565353.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59536" checksum="A3B52D32C4DC85DF" modified="2020-12-02" version="1">MAAAALKKCANIFTVNKLLVSIRMKSFRALGVNDIISNRLEKLGIVEPTEIQEKAIIKVSSGRNTIINAETGSGKTLCYLLPIVNKLINEPSLLDSPPHALILLPTVELCHQVAAVFKSIAEPDMYPSIVTRDSNLLVNRNYPVVMAMPSSLLSYNLDVLRHVRVVIADEADFLITSGGKDVWKLLNFFKYGKHLKKKSKYGSKFNQKSILRSDKRTDNKGIPDTTVSAQRQFLFVAATLPSRGKKASLNVLTKWLYEPEVVTTSIVHQTLPTLDMEYVRVTEDTKLKELLRVLNKLVCLEYENDTINAKKNSEILSGENLHSGNEKIECDKTSKNTDGNRKALRVLVFTNTAQQANKVFEFLSNSEDQLSIQQKSFIVNQNNSTQLNKGTLIDNYWQDKCAELHKDVAVEKRLDSLERFKSGELKVLVCTDIASRGLDIPDVSHVIQLDFASNAAYVLHRAGRTARAGAHGKVINFITTKDEDLARAIQACDDDPDTDYDSTFSRNRMFRRRIKRNVLPLADFIEYTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBT7</accession>
    <name>A0A6P8IBT7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116300177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564846.1">
        <property type="nucleotide sequence ID" value="XM_031708986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBT7"/>
    <dbReference type="GeneID" id="116300177"/>
    <dbReference type="KEGG" id="aten:116300177"/>
    <dbReference type="InParanoid" id="A0A6P8IBT7"/>
    <dbReference type="OrthoDB" id="5963173at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF6">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031564846.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="46619" checksum="D75970FB935D1FCF" modified="2020-12-02" version="1">MALERSKVFYKFELFKYLFGAIFAWSDVGSDIATCILYYRRSQFEEFGFCLAFALAPSIFMTVAHLVQHLRSDGIVNIIGNLVYYAFFGSGMMKMKLFILCVKNFKEVWSRPGYLVMKEDEKNDIRTVAVYDYIQTLLEDIPQMVLQIYTLTQQDTSNIHWIQFVSIALSFVNLILTLALFENNTLPGVQNVKAYILVILFYNTFLLAARIVTIVSFLIGFSWITAIILVVHELVCIVFYYIKNRKRFTDKDVWWVAIILLPCYIFTYLGFKVKEIRLRSFELKISRSLLSSSLYYATFTIENIMMMSLYYSKASVRTWYSSGATAAVIMMTLVGVFLNLIFTNLYFRDYHRTRHMISHQGVRRASRFERNSRVRFSRSVRVHPHPLDRDQTVTEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBW5</accession>
    <name>A0A6P8IBW5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Transient receptor potential cation channel subfamily V member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116298687</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563077.1">
        <property type="nucleotide sequence ID" value="XM_031707217.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IBW5">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="GeneID" id="116298687"/>
    <dbReference type="KEGG" id="aten:116298687"/>
    <dbReference type="InParanoid" id="A0A6P8IBW5"/>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF28">
        <property type="entry name" value="NANCHUNG, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="499"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031563077.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="88017" checksum="FB5072C45966832E" modified="2020-12-02" version="1">MGNRNSTDESIRAGQDVIKQAENAFHELYRYVDLKGGGKLVTAFRRAQTTKDYTEVNNIIQNELRRFLYNDGNAKLVPVADIVTIRQGSRQQASSSNPKNIQRSWKLCGWKPIRVKNTSQVGLINDSFTLETLRDFNGCHEYRQMCWHLNHLGAVGESLLHLCFLNATKVHYDLAKKLLSVYPHLINDIYISDEYYGENCLHMAIVNENLEMVHFLCKKGINIHERXYGAFFCPEDQRDSREDEESKEAXELKAETNYKSHTYWGEYPLSFAACLGQEDTVKYLLQRKACPNXQDTNGNTALHLVVIHDRPDMYDLILDYGCWCDCGCNEXKSDVKNVQGLTPLTLAAKLAKKEMFHHIINRGSKVFWEYGGVSCAAYSLKDLDTTDSQGHILEASALNIIIHEDSREHLELIDGIIHKILDLKWHKGCRFRFFQLLLLYIVYLIFIGVALALKPQHPNCKDTVNATHVNLSSSIIATNGTSTGEQCDPCYLIKDFLYESTNQRVRLAFEILSTVWAVSFLVLLVFEMVMQGFKSVVFGLVNNPIRGLFALSCAIVPCCLISRFMCLVALEDHFTVISLVLAWPYALMFCKGFSLTGPYVVMIYQMLKRDFIIFFIIYMIFVIGFSQAMFLVMLGYSDSTVKENLFSRWFSSGLGLIVMSLGEFGDLHSQLMETNSPFKIIGLIMFFTFMVFGALLIVNMLIAMMGNTYLAVAETEKEWTRQWAKIVLNIERMLTPKQKTKLKMKYCESLDSKGELYFIMKVRHPQNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICR5</accession>
    <name>A0A6P8ICR5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299146</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031563637.1">
        <property type="nucleotide sequence ID" value="XM_031707777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICR5"/>
    <dbReference type="FunCoup" id="A0A6P8ICR5">
        <property type="interactions" value="2924"/>
    </dbReference>
    <dbReference type="GeneID" id="116299146"/>
    <dbReference type="KEGG" id="aten:116299146"/>
    <dbReference type="InParanoid" id="A0A6P8ICR5"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000002">
        <property type="entry name" value="Probable histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000031">
        <property type="entry name" value="Putative Histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF10">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="14">
        <location>
            <begin position="298"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563637.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="69627" checksum="672F94E679A559B2" modified="2020-12-02" version="1">MEARADGNYLSLIESCYIPIISMDHPMHSRSDTILRSFIECSLKIMKGESSLVIHEAGECTIDVRQEPSSKNCDVQVRCGSEFSPHFRVCADTNHSQVGRLRYLIDLPEHCCSIIITFSRNEEVKEFRTLLSQSKARSESESTFNERTDEASAMQYFQFYGYLSQQQNMMQDYTRTSTYQKAMLQNHVDFEDKVVIDVGAGSGILSFFAVQAGARKVYAIEASSMAMHAELLVKKNNLEDKIIVVPGKVEEVHIPEKVDAIISEPMGYMLFNERMLESYLHAKKWLKPGGKMFPSVGQLHVAPFSDDALYIEHFSKANFWYQKSFYGVDLSSLREAALKEYFKQPVVDTFDERILMAKPVTYSVDFLTSEEDDLHRMEIPIKFTLLSSGSLHGLAFWFDVCFKGSQVPVWLSTAPHEPLTHWYQVRCLLETPIFVKAGQSVSGTVLLVSNARQSYDVDFEIRLDGTTIRTRNTVDLKNPYFRYTGSTPQPPAGYNNESPTEVYWSLASNGDSSHTANAVNSNAVGGGGGSGCSPSVMMGESMTNTTGMHSNSLYNNTGGYVGGQYWGGNAYGNVTSLQAMQNYSGSFGAINNVNTSYIASSQPAMLYSQTSGRNAVMTGQNQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDC3</accession>
    <name>A0A6P8IDC3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">A disintegrin and metalloproteinase with thrombospondin motifs 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116298938</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563380.1">
        <property type="nucleotide sequence ID" value="XM_031707520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDC3"/>
    <dbReference type="GeneID" id="116298938"/>
    <dbReference type="KEGG" id="aten:116298938"/>
    <dbReference type="InParanoid" id="A0A6P8IDC3"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="16">
        <location>
            <begin position="237"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="12 15">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="343"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="360"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="536"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="540"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031563380.1"/>
        </source>
    </evidence>
    <sequence length="824" mass="91032" checksum="8F671CAFE21E0581" modified="2020-12-02" version="1">MNLPMKLYLNFNYGLLVVLGSQLLCLDGLKRIPRHELHKAMATDREEMIRLFGEDSAETVPDYKIAVVRPHRTRRGIEDGSKQYRLSAFGEDLHLVLEPNDAVVSRSLIVMKKLPGNKWTQELYTPEGRFLQGHVVSHPNSHVAVRELKNDKEMTGGIFTDGFLYRVHPVSKKAKKILSLKGQGHHVITRRSMKDPKTGFLNNPAFFPKPVRVFDQEEDTVVYGRQRTRKRRDLSTKYIEGMMTLDKVSCDYYGQESMSVVLAIANMANRLYQDKSMEPDVRFVLTKVILVKAFEAGLDVQQNNIDSAVKYMGLFAKWSKDKNSAPGEAGHFDNGVLLSRDICGLKDCVLGGVAYSGVPCSSTLAYTVNMARGIDAAFYVAHEMGHNFGLPHDNGACNNGHIMSAGQGSGPNSFQWSKCSSDRLKSILGRVTCFDNKPPTSISVPKLPPGYTLNGDKQCKMLLGSSYRLCPLTLDNCALLFCMKSGGCSSLGTAPVDGTPCGVRKWCIRGECTDVGSSVPPAVDGGWGEWGPYGECTRTCGKGIRYKTRVCDNPSPQHDGKPCPGLSIGEFQICEKQPCASNTNYRMEQCKKKKSDYTGYTIRGNPCYLWCMEGNVGRGEGTVADGTRYSDEPLNHDICIQGKLVSAGCDDVIDSGSTYDRCMKCQGDGSACVPVKGVYDKDHQATGVSNADKMFDIPIDSTYFQIKEKSPTRNVLNIKLKNTDSFIFPNRPLTSSREAAGTTIEYIINNNNLNDAETMKFTGPNKQVLVPMFVNVMGDTNVGYDYFYYKPGQGSKTTFVWRYKATGSCSATCAGGSNLKFPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFY0</accession>
    <name>A0A6P8IFY0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cylicin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565644.1">
        <property type="nucleotide sequence ID" value="XM_031709784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFY0"/>
    <dbReference type="GeneID" id="116300828"/>
    <dbReference type="KEGG" id="aten:116300828"/>
    <dbReference type="InParanoid" id="A0A6P8IFY0"/>
    <dbReference type="OrthoDB" id="10493179at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565644.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32375" checksum="AC0B8B1BA3EEDF05" modified="2020-12-02" version="1">MDRTQGSTRQHKAAQGSTRQHKAAQGSKEAQGSKATRQQGSKAARQQQQDSKAAQGSKAAQGSSKAALGSKAARQQDSKTARQHKVARQHKKAQGRTNKTARQHKEALGSKAAQGSKRQQGSKTAQARQQDSTRKHKVARQHKEAKGSTAARQHKEAQGSKTARQHKDAQGSKEAQGSKRQQGSKEAQARQQDSTRKHKAARQQGSKRQQGSTSKTARQHKEAQGSKAARQQGSTRKHKEAQTRQQDSKAAHKKSEEEGKREGGDGKESRKERNEIREKGASKEASKQQARKEAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHU5</accession>
    <name>A0A6P8IHU5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116301473</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566401.1">
        <property type="nucleotide sequence ID" value="XM_031710541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHU5"/>
    <dbReference type="FunCoup" id="A0A6P8IHU5">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="GeneID" id="116301473"/>
    <dbReference type="KEGG" id="aten:116301473"/>
    <dbReference type="InParanoid" id="A0A6P8IHU5"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031566401.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="53566" checksum="41FF61B742EA10BE" modified="2020-12-02" version="1">MSADEKNPAFESESLTINDTTKEAITLKRSLGVPGGVALLVGTIIGSGIFATPKWVVIYSGSVGLSLVVWSLCGLISLLGALCYVELGLLIPKSGGEYVYLMEAFGPLPAFLFSWVYSLLLKNGGVAILVLVFGSYVVEPFYPGCTDRQDLVQLQKLLAVIALGVVIVVNCASVKWASRLQIGLTVAKMVAIVMLILTGIVRIAQGHVSSFTNAFKGTEPRLSVIGFAFYNALFSYDGWNNINYVIEEFKNPKRNLPLSIWIAVPVVSASYVLVNVGFLTVLSGDEVMKSNAVAVTLASRLYGVMAWTIPFLVACSVFGSVNGSAFAGGRLIFAAAREGHLPQLLAMIHTKQRTPLPALLTSFIICTIMVIPDTSSIASLLNAFSLLVWFNYGVTLSALLWLRYKKKDSERPYKVFIVFPCLLILLSIYLVVASFAQSPVSSTLCFLFVLAGIPVYFVFVRYKFVPGCIDRVTLWLQKFLNVALPQTEKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJD9</accession>
    <name>A0A6P8IJD9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116301845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031566857.1">
        <property type="nucleotide sequence ID" value="XM_031710997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJD9"/>
    <dbReference type="FunCoup" id="A0A6P8IJD9">
        <property type="interactions" value="2680"/>
    </dbReference>
    <dbReference type="GeneID" id="116301845"/>
    <dbReference type="KEGG" id="aten:116301845"/>
    <dbReference type="InParanoid" id="A0A6P8IJD9"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="343"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031566857.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="60153" checksum="DABB2B95DD416ADA" modified="2020-12-02" version="1">MALASLQGHGHSHGNGNGHGHSHGNGLGHGHGPGGLFADMGGTFDKPYPIQSSGPLQAEVAPSPFGDAPMVEMDYSLFDLVKATQYGILSRVKELVEKEGVDPKQTDNENIQGHLQIVICLMKHKANPEIQDLALHWSIMSNNHNVLHPLAKAGASLDAVNAKGEVPGDIAAEKKNKWISAQLDLIARDRGKGKPAFLQSFIRDKETRRYVLLVTPIVSMFLIGAILEYSPTWYIMLLLLGVLSSVIWYIMRFLNIQTDPGNVLPCAIYLATKCYMYTTWFVYYWPFVKTPKVLIIFFANTAGLMYCFYKAWTTDPGYLKTTPAEQKRTIIQLAEKNSLDFVHFCSTCLIRKPIRSKHCSVCNRCVARFDHHCPWVENCIGSGNHHYFIGYLFFLFVMINVYTYGAFVYYINVCSGYTGGWWDAISRSAHCSPWVSWGFGNAMFHFLWVGALFFCQSYQLFWVGMTTNERLNMGRYSHMMDHTGVPKSPFSRTVIGNIADFFGFSFFGLIRPKRVDWKRQYSVETNSFNQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJN6</accession>
    <name>A0A6P8IJN6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Steryl-sulfatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116301967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566999.1">
        <property type="nucleotide sequence ID" value="XM_031711139.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IJN6">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="GeneID" id="116301967"/>
    <dbReference type="KEGG" id="aten:116301967"/>
    <dbReference type="InParanoid" id="A0A6P8IJN6"/>
    <dbReference type="OrthoDB" id="5983437at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.550">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF49">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028200576" evidence="7">
        <location>
            <begin position="22"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031566999.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="64823" checksum="2B925A81F2923624" modified="2020-12-02" version="1">MHTMDFLVILQLLLVSTISTAQSNIVIFLVDDLGIGDIGCFGNDTIKTPNIDKLAREGARLTHNLAPESVCTPSRAAFLTGRYAIRSGLAANPDRTRMFLFLSVPGGLPQNETTFAEVLQDAGYATGLVGKWHLGLNLHTSDDYHFHPMRQGFQHFYGLPLTNVRECKAGHFIFELIFPNLQRNLCYTLILVGXSAVVCCLGGLLSKRSAVFIIILCVSIYGSFLFALKLRRHFVCFLMRDYEVVEQPVVFENLTLRLTHDAVQFVEDHKSKPFLLFMSYVKVHTSLFTSKRFEGHSVHGQYGDNVEEMDWSVGEIMNALERLGVKNDTFVYFTSDHGPHLEESSGGEYHGGWKGIYKGGKGQSWEGGIRVPTIVSWPSHIPPGINITEPTNSFDIFPTIIDITGSSVPQDRIIDGKNVMPLLLRQEKYSPHEFMFHYCAKEVHAVRYRPRHGETTWKAHFTTPKWIEGTEGCNGMCHDCYNHGIIRHXTPLXFDITSDPSESHPLNPQATQYRDVMEKIIAAVKEHQDHVDDVPNQLDLNTFWYLSRMQPCCNYPFCSCIENTXQTNPLTTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IL55</accession>
    <name>A0A6P8IL55_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116302518</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116302518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567696.1">
        <property type="nucleotide sequence ID" value="XM_031711836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IL55"/>
    <dbReference type="GeneID" id="116302518"/>
    <dbReference type="KEGG" id="aten:116302518"/>
    <dbReference type="InParanoid" id="A0A6P8IL55"/>
    <dbReference type="OrthoDB" id="10332143at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031567696.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15648" checksum="187CA8CF1570846C" modified="2020-12-02" version="1">MAEEEKPKSRRECLLCLLWFCCVLLTLAAFTFSMYTVKEFATLKARIGDLESQLSLISGNNLGYSEKDYMASRRTLPQSNKIWHTSKEDKKNKIHEINKRETQKPYKDRSNVFIHLSGGLKARRDRNLIKHLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILX3</accession>
    <name>A0A6P8ILX3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sperm-associated antigen 17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567615.1">
        <property type="nucleotide sequence ID" value="XM_031711755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILX3"/>
    <dbReference type="GeneID" id="116302462"/>
    <dbReference type="KEGG" id="aten:116302462"/>
    <dbReference type="InParanoid" id="A0A6P8ILX3"/>
    <dbReference type="OrthoDB" id="5973991at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026173">
        <property type="entry name" value="SPAG17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963">
        <property type="entry name" value="PF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963:SF1">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567615.1"/>
        </source>
    </evidence>
    <sequence length="696" mass="78109" checksum="63F5C907BB33D65A" modified="2020-12-02" version="1">MSKSKRGKSASTNEISKWEAEFSQAPFNEESWRSFVFFIAPNKQEDNAYVDVLSDVVSTGLRKMFSVVTEEGLMKDVRDFGKVQTGGKGKGAPATKAPAFSEVCEQAKAVLDQGETILPSMMAKLVKFKLLQIKQKDLDRREEERKAAKAAESAKKDDKGKKSRSPSGKSRSKSPGKKKGKKDADLPPSPKKDTKLKKRGDVEDTFKAIDDEPDDEGSPQHYVLIHGIWMAPVINYMAELGINIDAIICIKSETYDKKEEVKGTEEQQATEEQDPEVLEKAMKEEEERAKKLEKDKQLQTFWIETDNIVLNAQSGNKLKDIAKYEVMVKDKDIPEVSLQELEDEKKVDFGTIIFEDVAVTCYNMLDHYVMYKQYLESMKLVQVPVHSLAGAEATAVAPFVPELLSSQSATGVQAPETQAPIPVEVDTRYYKHLMDTVPTDSHSIPLILHCLLEQVTATVDESNPLDKEVPPRDDGLNHLLAAHIDSKAGKLVLTENEKKTIFSGNAKEEKKTANSNGPIMLHHGDALTSQAHHLQPQNGLNPLQAQLQMLQFFPSSALKDLPEPKGREIAERAARANELRHFLMSKSVNPAILDHVLKQYAFEGMLLKTVTDDGFIIDPVDLDEAFRSYSNPWDYPYNKLEDFMKVKFCSDESGNLKIAEVDSNSPLTSFRNLDDWCFVEHFDQTTLLQVFLNSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INA1</accession>
    <name>A0A6P8INA1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568339.1">
        <property type="nucleotide sequence ID" value="XM_031712479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303037"/>
    <dbReference type="KEGG" id="aten:116303037"/>
    <dbReference type="InParanoid" id="A0A6P8INA1"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="128"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="191"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568339.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="31098" checksum="E466CD0A97B2DB68" modified="2020-12-02" version="1">MAKIINTSTTSIFIVTSAARVSIPPSXSMCYVVVSVTFHNSQWGTVCQDYWDMEEAKVACRQLGFTKTLGPWWYGRGXGPVWLDDMGCTGSEASLQNCPHAXWGSRWPTISKWGTICDDDWDMNDATVACRQLGFTKDLRFWHXGRGKGPVWLDEMSCTGTDASLHSCSHPGWGNADSGCRSHNEDAVKFVYHIGQWGTVCHDYWYMEEARVACRQLGFTKALGPWHSGKGTGPVWLDNMGCTGSETSLQXCSHPGWGVSDSACKTHKYDAGVVSYEKPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPB0</accession>
    <name>A0A6P8IPB0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein F54H12.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116303012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568310.1">
        <property type="nucleotide sequence ID" value="XM_031712450.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303012"/>
    <dbReference type="KEGG" id="aten:116303012"/>
    <dbReference type="InParanoid" id="A0A6P8IPB0"/>
    <dbReference type="OrthoDB" id="5975932at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031568310.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="48943" checksum="F3A73C84578FB8EA" modified="2020-12-02" version="1">MKNQRGAGXMMVFHGXRFQKGXGQVGYGLXSFFQSLARXAMPFLQKGAQSLGKATLDAGVNIAKDVLAGNNLKDSAQARLQQTAKTIKDQALNHITSQQVDVFLNGIQVTQSTGTYSYKSMLETLLNYGFSAKKSHLTAGLYYKDTAGAMDETDCTDEGDNKGLQTRYSFTKESYIVDLWGPLHCDMLFSDRLLLNHVDVTIKLNPNSSAFALMSGEASPNYKIAIQSANLKVRAVKISPTLQLQHLTELKKGVNAIYPVRRTDCKTYTIPLGNPSIHKGDLFNGQVPKRVXLAMVDSDAFNGSYTKNPYNFQLYGATSISLTXDGEQRPFKPIALKLAQARERNFMEVYQTLFSGTGRLYTDSGIDIAREDYNQGYSILVFDLTPDLCSSSTHLNQKQKGNVSLEVQFSTGLPNAVNLIVYGEFESTVEIDFARHVTFDYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IPF5</accession>
    <name>A0A6P8IPF5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116303038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568340.1">
        <property type="nucleotide sequence ID" value="XM_031712480.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116303038"/>
    <dbReference type="InParanoid" id="A0A6P8IPF5"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="106"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="207"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="578"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="678"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="780"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="854"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1172"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1321"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1404"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1454"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1225"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1373"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1506"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="13">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="13">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="13">
        <location>
            <position position="1177"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="13">
        <location>
            <position position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031568340.1"/>
        </source>
    </evidence>
    <sequence length="1529" mass="169448" checksum="B5F6725734D490A6" modified="2020-12-02" version="1">MPDAKVACGQLGFTKTVGYWQYGRGTGKVWLEYMQCSGTETSLQSCXXNGWGSVPXCDHTTDVGVLHVDGTSLLXLNGTVXYGGWDMDDTKVACRQLGFTKALGPWQYGRGTVDTAKCVVEVYHEGQWGTVCRGCWDMPDAKVACRQLGFTKTVGAWDWGHGAGKVWLDNMGCSGSESSLGSCSHGGWGSVASYCDHSTDSGVVSFERFITTVNGEQFVMVTEVNGQWGTVCQGGYNNDFDINDAKVACRQLGFNKTLGPSHFGQGTGKIWLYNMRCSGSEASLXSCSHNGWGQVSGCDHTRDAGVSLTNECHEYHYVXHDGVRTLDVGEVEKSLRNLNQNKSAGHDQISPRLLSIASNELSPSLTRIFNGCIEKRYWPDDWKKGIWVPVFKKDDHKDLKNYRPITVLSTIDKVFEQLLAGQVSHYIEPYLNRNLTAYRKRNSCETALINLQEDWKKSLDEKRVIGVLSSDLSKAFDSLNPPLLLAKLKGYGFGDDAIELLLSERKNRVRMGSEIMSEWKTVNRRRGEDIDELNDGLNIMNWYENNLLKCNNDKFQTVSFGQKHKNKNLNITALNKNIKANSDMTLLXVTIDEYLNGQWGTVCQGGYNNVFDINDAKVACRQLGFNKTLGPSHFGQGTGKIWLYNMRCSGSEASLGSCSHNGWGQVSGCDHTRDAGVGQWGTVCXGGWDINDAKVACRQLGFTKTVGYWHYGRGTGKVWLTGMGYLGSETTLGSCSHWAWGNVGSCDHTVDVGVLSTDTVILRGTKIRYNINKTYAIKLGTVCTGNWYMDEARVACRQLGFTKALGFWWNGYGTDRIWLWNMQCTGSETSLGSCTHNGWGSVYSGCDHTNDAGIYYQGQWGTVCYGNWGTNDAKVACRQLGFTKTIGRWYGGRGTGKIWLYGMGCSGXETSLGSCSHWGWGNVGSHCNNHQCQSGKYMSDPSFRNPFRYDXVLDLIVDKYKLQLCHGYWDMQDAKVTCRQLGFSKTIAYWEYGRGTGKIWLYDMRCSGSEASLGSCTHNGWGSVHSACDHTNDAGVICFSNIVEICQQSQWGTVCDGSWNMPDVKVACRQLGFSKTLGPWYDGRGTGKVWLNGMGCSGSEASLGSCSHNGWGXVSSYCNSHADDAGVVRFCNGGNECYNKCFKSTTEETSALLWFENYVLVIFNRVLHVCLFEVYYEXQWGTVCHDGWYMEEAKVACRQLGFTKTVGYWRYGXGTGKVWLNYMDCTXSESSLQSCSHDGWGGHGSSCDSHQYDAGVHARLLFXCDMLLGCVLGPLLFSFYISQMEDTMVYAGNTQIYIILMEPDKAASLYRPKPCIRDIREWXFPNKLGTVCHSNFDINDAKVACRQLGFTKTVGFWDYGQGTGKVWLNDMGCTGSESSLGSCSHSAWGNVGSSCNTHQYDAGVVYFGQWGTVCHYGSWDMDDAKVACRQLGFTXTLGPWYWGRGTTILLVIKEVYYQGQWGTVCRGNWEMDDATVACRQLGFTKTVGRSYYGRGTGKVWLYNMGCSGSEXSLGSCTHSAWGNVGLSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRP8</accession>
    <name>A0A6P8IRP8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Parkin coregulated gene protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569821.1">
        <property type="nucleotide sequence ID" value="XM_031713961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRP8"/>
    <dbReference type="FunCoup" id="A0A6P8IRP8">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="GeneID" id="116304252"/>
    <dbReference type="KEGG" id="aten:116304252"/>
    <dbReference type="InParanoid" id="A0A6P8IRP8"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569821.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29894" checksum="666BB516BEDF6FBD" modified="2020-12-02" version="1">MATTHAMRTRTEHVFGPTTEGIKTKSSHEKSHSTVREEKTRALTADGFTTKSRLKNSKVVQPPSARAFKERPAEPTNFRKCYERGDFPIALEHDTKGNKIAWKVEIEKLDYHHYLPLFFEGLSETSHPYEFFARQGVHDMLEHGGKKILPVIPQLIIPIKKALNTRNAKVICTSLKALQHLVVAADLVGEALVPYYRQILPILNLFKNKNLNSGDGIDYSQQRRENVGDLIQETLEGFERRGGADAFINIKYMVPTYESCMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISI7</accession>
    <name>A0A6P8ISI7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569939.1">
        <property type="nucleotide sequence ID" value="XM_031714079.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ISI7">
        <property type="interactions" value="2324"/>
    </dbReference>
    <dbReference type="GeneID" id="116304353"/>
    <dbReference type="KEGG" id="aten:116304353"/>
    <dbReference type="InParanoid" id="A0A6P8ISI7"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569939.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25274" checksum="C92996143F76E2B3" modified="2020-12-02" version="1">MDIQQTIQDTVLQAAKVVEEQVDSEIDRLEKMTSDDMDELRERRLQALKKQAQLKSEWLHKGHGTYSEIANEPDFFPDTKDSPRVVCHFYRDSTFRCKIVDKHLALLAPKHVETKFVKINVEKCKFLCDRLAIKVLPTVVMIKDGKFVDRIVGFDELGGHDEFSTNMMEWRLARAEVINYAGDLSQPPDKPKTGTTVLKKSIRGRXDKDDDDDDDDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISJ1</accession>
    <name>A0A6P8ISJ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integrator complex subunit 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116304359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569944.1">
        <property type="nucleotide sequence ID" value="XM_031714084.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ISJ1">
        <property type="interactions" value="3057"/>
    </dbReference>
    <dbReference type="GeneID" id="116304359"/>
    <dbReference type="KEGG" id="aten:116304359"/>
    <dbReference type="InParanoid" id="A0A6P8ISJ1"/>
    <dbReference type="OrthoDB" id="5844105at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="616"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031569944.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="80248" checksum="375CA3EEB7444661" modified="2020-12-02" version="1">MFENKLGCCPRTTVFVLDRSSRFLSLSKQHIDLDGTGKSKAQAKGSKSALGPVYKNAWTCCVEATIEYCRIIYDLFPNEYMAQVIVSDEKAYKVNAKSPDQQNVPHLLRTFANLGPPKPDNEEECSMLHGLTMAVQCAGEAAPMTKFQTERCADEDGKVRIICLTSLKNEAHVNTLVACVNDALQHQTGSAPVQNLELILIHVIHASDSSKFTEKVPKVSPMMSVSIHSIKSSQLVLKSSLMVQKHFNLKSTTVTGIPMKEEQHSGSSANYDVEILHAAEVHHDLTVFSQFCSNNTVSAAVVSSNASSSSSTSGKKDAPAKETVILKWCTPKNSTTNELFPCLGSYRITPVEVNSRPASCLISFLLQGRSVMLEQPRKLGSKVVSHILMSHGGDIYIHSVSTSRTPNEDPPSISEGVGGRVTDYRINDFGEFMKSNRLAPWPKKKGQANVNVLEKSHTRLERCTRHWPIVISDTIIGNMMPHLEPLVSLIMKETLTDKEVLDCKSVIYRLQSMESRNDVLPITITGVRGKGPKREEQYRQLWAELETFLDAASKTSKMHEKIYDCLRVPQSPDHSSHSSPMRTTPTDEIEGMNIGSGFSSNELAWREIDRYHGMSEREKTDFNRGDANNDHFSKRPRNTPDIERSQKKFKPDDRLDIPQKPGLTSSGPSLLSLWTXRMNSIAAKRHEEFAGRLHTDGNQAELYPQLNMDGNGSGRGTPPVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISS1</accession>
    <name>A0A6P8ISS1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116304445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570039.1">
        <property type="nucleotide sequence ID" value="XM_031714179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304445"/>
    <dbReference type="KEGG" id="aten:116304445"/>
    <dbReference type="InParanoid" id="A0A6P8ISS1"/>
    <dbReference type="OrthoDB" id="5989317at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="340"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031570039.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="59818" checksum="BCEC301CEF21EED1" modified="2020-12-02" version="1">MNDNVSGSTRDTNQENNKEAPMNSLEGNEKMENTQEKDTFFGLEKKYLIPKGFYFFFFSAQGSLLPYLSLFLKQLELPASQVGIVTGIKPYIAFFFIPIWSAIADKYRISKPLFIVSMLAINLGLVAYAFVPVDLCEEDHVVSKKIREPTQNVTSLMEKLSQIAEDSSDETPWXQSQEGIAYQYTGNTHDRKTMGVFLYLLLITVFSSTISCPSLTLGDSATVQQLKENNETHKYGKQRLWGSIGWGSMAFLVGAAVSRTHLCPPGSAKGKDVNYYPCFVAYGVFMLTALGIGFKLKFDDRPADLSEKSDEEEKEAEKQAYVKSKTKGIIEGIRILMTPRHTMFLVTVFVVGICMGLIKVFLFWHLKDLGGSQLLFSYMAAINCIAEVTVYFLSSKLISTMGHIRVLYLGLFCYSVRLFFYAFITRPWYILPIELLSGITTAGVWASLMSYVGIHSLEGVTVTLQGILHSVHWGLGHGCGEFIGGFFISAFGASTTFTLFGIVSLLDLLAYYLVDTFAPKERGYKEIHSDVEPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV10</accession>
    <name>A0A6P8IV10_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leukocyte surface antigen CD53-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116305089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570782.1">
        <property type="nucleotide sequence ID" value="XM_031714922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IV10"/>
    <dbReference type="GeneID" id="116305089"/>
    <dbReference type="KEGG" id="aten:116305089"/>
    <dbReference type="InParanoid" id="A0A6P8IV10"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF534">
        <property type="entry name" value="TETRASPANIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570782.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31080" checksum="2EDF5FB7C82CF30B" modified="2020-12-02" version="1">MVFMNKSTLCIRWTAFFLNTLIWIGGSIMLGLSIWVYSKETEFDHMASDKTASACYLALSVLLFVIGFLGSCAILLLKPSLLKIYFSFIMTILLAELSVSLYLYFEQDKIKGFVEKNWNATNDATRTLIQEKFECCSMDPVITSHSSSEDSSCYEKNADNTMARRRDCYTQLLSWVKRNNIALATSAVLVALIQVFLLASSCRLLATIDSGDRMIRQIKVRPLASNNELHPDGSTASYTPPSTPVRHIIERKEWAKLSSKRSFRNAFVEGKTSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVG2</accession>
    <name>A0A6P8IVG2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptor moody-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116305242</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570962.1">
        <property type="nucleotide sequence ID" value="XM_031715102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVG2"/>
    <dbReference type="GeneID" id="116305242"/>
    <dbReference type="KEGG" id="aten:116305242"/>
    <dbReference type="InParanoid" id="A0A6P8IVG2"/>
    <dbReference type="OrthoDB" id="2101615at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="341"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023040"/>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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            <dbReference type="ARBA" id="ARBA00023224"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="RefSeq" id="XP_031570962.1"/>
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    <sequence length="366" mass="40678" checksum="83FD7FA4E2E54A53" modified="2020-12-02" version="1">MNNTNSSVVNLFTYSLVLAPRPIFEVIFESLSIIIIIILALFGNILILIVVYKEGGFKKSSNILLINLAMTDVTSAVLGFPLVLVTIATGRWIMGDVMCQFQAYMSYVLYSCTLCTLTVVSVNRYTLLSKPHFHRKIFGRRKTVALVIGIWVTSFSFATPPLIGWSRYVFLADYAICVTDPIASPSFNTFLFLFLLVNMFIIIFCYAKIFSTLKRIKKLGAQNPDAVANQSARQPVANQGPGAPANQDIGAPVANQEPEHNEENVNGESNPSQANQNLASRSNEIQITAIIFIIICLFGFCYLPTFIVGFFVFSSSSITRSMRLFSTFSISLTSVVNPFVFCIKSKAFRKLAKQIYRGITGCFQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW23</accession>
    <name>A0A6P8IW23_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305698</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC116305698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571526.1">
        <property type="nucleotide sequence ID" value="XM_031715666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW23"/>
    <dbReference type="GeneID" id="116305698"/>
    <dbReference type="KEGG" id="aten:116305698"/>
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    <dbReference type="OrthoDB" id="5974437at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:DNA damage checkpoint signaling"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:recombinational repair"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029293">
        <property type="entry name" value="RHNO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35541">
        <property type="entry name" value="RAD9, HUS1, RAD1-INTERACTING NUCLEAR ORPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35541:SF1">
        <property type="entry name" value="RAD9, HUS1, RAD1-INTERACTING NUCLEAR ORPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15319">
        <property type="entry name" value="RHINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571526.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="25500" checksum="C397318E1FA3550C" modified="2020-12-02" version="1">MFPKYGNPKGFLVRVPCGKSRGGIFKMASKRKKKRKPSELMERFKPPLMFVESPIQGSKHYCTPVQAARNPYMAPSIPVDNLTAKWVSPQFTLHENSPIFQETRRRRRKCKKNSEDERQTQRNAKMTIASLDFENKAKSARKKTRIKTTLRRSTRIKAKELDKYEHFLFGEGTSVTPNVRKMKVLAPETPECHVTMIPVVLRKLRLGHDKNEKFKVQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW39</accession>
    <name>A0A6P8IW39_ACTTE</name>
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        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116305721</name>
    </gene>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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        <lineage>
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            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
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            <dbReference type="ChEBI" id="CHEBI:57856"/>
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            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
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            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
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        <property type="nucleotide sequence ID" value="XM_031715691.1"/>
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        <property type="interactions" value="2550"/>
    </dbReference>
    <dbReference type="GeneID" id="116305721"/>
    <dbReference type="KEGG" id="aten:116305721"/>
    <dbReference type="InParanoid" id="A0A6P8IW39"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="19">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="18">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="20">
        <location>
            <begin position="365"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031571551.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61383" checksum="836FF8BD6555B234" modified="2020-12-02" version="1">MAASLDRESPPLRESDDDDDGWEEVDENSETIAKCLFCSETCEGAQKTFQHCLDVHNFNLPTIKHSYGLDFYGYIKLMNYIRKKNPSPDSFKTLFSHPYPWDDQEFLQPVLEDDALLWYDFDEEVAKDEGERKVMNGAGNEGTVSHTDYMELKQRLLMMEERATTAEADLAKARDDIQQLRMVAKSFLEEDISKTNRTHKNCQSVNRGGNDGHDDDEDSAYFSSYAHFGIHEEMLKDKVRTESYRDFILGNPNIFKDKVVLDVGCGTGILSMFAAKAGARHVIAIDQSEIIYQAMDIVRENGLDKTITLLNGKVEEVTLPVDKVDIIISEWMGYFLLFESMLDTVLFARDKWLSPGGIVFPDKCSIHLVAMGTLEDQTPKINFWDDVYGFKMSCMKTSVIKEPSVSVVNPNAVISTVSCIKSLDINKCKSEDLNFISSFKLKILKDDQLTAIVAYFDIVFEQDAVKKVEFSTSPGQQPTHWKQTVFYLKDTIPVIKGQSLSGHLSCYKNLKDTRSLDIRIELVDIKTQKVLFEQEYLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYE4</accession>
    <name>A0A6P8IYE4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic spindle assembly checkpoint protein MAD2B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitotic arrest deficient 2-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116305147</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570849.1">
        <property type="nucleotide sequence ID" value="XM_031714989.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031570850.1">
        <property type="nucleotide sequence ID" value="XM_031714990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYE4"/>
    <dbReference type="GeneID" id="116305147"/>
    <dbReference type="KEGG" id="aten:116305147"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000003">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="13"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570850.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24408" checksum="A2D17AB931C71B0C" modified="2020-12-02" version="1">MDGHDKEPFNAQAISAGVFCDFLEVAFHLILYVREVYPAVVFERRKKYNVPVQMCCHPDLNHYIQDVLVTIKPLIEKNEVSKISLVISNKSFQPVERFTFEIAQPDDISLSDDNLLLHTESALRAFLLKINVCDALLKNNPSECTFTVLAYTKESAHVELQSDSKHEEFPWIPAEQESTSMSDFNIIPLKSMTSPILKMQMYVEENVQKKNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0E0</accession>
    <name>A0A6P8J0E0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARL14 effector protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572909.1">
        <property type="nucleotide sequence ID" value="XM_031717049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0E0"/>
    <dbReference type="FunCoup" id="A0A6P8J0E0">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="GeneID" id="116306914"/>
    <dbReference type="KEGG" id="aten:116306914"/>
    <dbReference type="InParanoid" id="A0A6P8J0E0"/>
    <dbReference type="OrthoDB" id="5984406at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029264">
        <property type="entry name" value="ARF7EP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536:SF3">
        <property type="entry name" value="ARF7 EFFECTOR PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536">
        <property type="entry name" value="ARL14 EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14949">
        <property type="entry name" value="ARF7EP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARF7 effector protein C-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572909.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20968" checksum="7F65E3284013174F" modified="2020-12-02" version="1">MDQESKEEKDSSTCSNEYKDENIDGKMAEESSNYLSIQASGCTARRTSIGSAEGDKTEKLLKILQFRNPGPQLASFDPDKSRREQRKVRQFVRTTDKHLNDDLNQVNLNGRRPRNPPKRRNYHDRSGIRLSDNKDVCDCQDLNCPGCHFPCDSCGSEKCGVECRCSRRWTYEPLVQIENPFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1U2</accession>
    <name>A0A6P8J1U2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multiple epidermal growth factor-like domains protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116306159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572068.1">
        <property type="nucleotide sequence ID" value="XM_031716208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1U2"/>
    <dbReference type="GeneID" id="116306159"/>
    <dbReference type="KEGG" id="aten:116306159"/>
    <dbReference type="InParanoid" id="A0A6P8J1U2"/>
    <dbReference type="OrthoDB" id="5948402at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031572068.1"/>
        </source>
    </evidence>
    <sequence length="868" mass="92962" checksum="5A82FDE5BED63E20" modified="2020-12-02" version="1">MTCNISCELDKYGVNCLVPCACVNGGSCDMTTGSCDCRPGYRGKNCEDVCPKGTYGPRCKLFCQCRNNEPCNHKTGACTCDPGYLGDKCNEVCPTGRYGKDCASVCACHLNNTDRCNNVDGSCLCKAGYHGKLCESVCPAGRYGRDCASVCACHLNNTDRCNHINGTCLCKDGFQGKSCESVCLSGRYGRDCVSVCECHLSNTDRCNHIDGSCLCKAGFQGKLCDSVCPQGSYGPGCSNSCQCGPDISCDPISGTCICPMGKMGLKCTEGCREGWFGFNCEQRCKCSYDIKCDPMTGSCVCPAGRTGKRCEQKCTSGTYGRNCREQCRCAGEARCDHVTGTCLCPPGITGKYCEESCPPGFYGIGCKLACGCPGDDPCDPATGQCACSPGKTGRTCELDCPHGRYGVNCHQRCACERNASCDPLNGVCHCPPETTGKRCEKVFGCLDVPGFCRNNGECNKSTSRCSCDDGWTGETCEAKCGEGFYGKDCQYACNCTAYENCNFVTGNCTRVCPRGFYGTNCSNKCACPKDAICDPRSGYCLCKPGFYGDNCKQSCPQGRFGRNCLYNCSCLGRAFCDAKTGKCFCTPGKIGPQCEYDCPHNTYGHNCKNQCKCIRGTCDPVTGACRCDPGYQGKDCGQECSRGRFGRNCAGTCTCRNAICDHVTGKCHCGLGWTGIDCEEACPPNTYGINCELDCACQNQATCDRVTGCCMCRPGWYGDKCQHSCPSGRFGSYCSKICECSNNALCDPETGSCFCQPGWSGNDCKQECSPGKYGLDCLAKCNCDSVFCDAKTGKCICSPGKAGWRCDEECPEGTYGPGCRHPCTCANNSTCDPISGKCNCQFGWTGSDCTKESKNEREFSDAHLFTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1V7</accession>
    <name>A0A6P8J1V7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC116307462 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116307462 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7" type="primary">LOC116307462</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573585.1">
        <property type="nucleotide sequence ID" value="XM_031717725.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573586.1">
        <property type="nucleotide sequence ID" value="XM_031717726.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573587.1">
        <property type="nucleotide sequence ID" value="XM_031717727.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573588.1">
        <property type="nucleotide sequence ID" value="XM_031717728.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573589.1">
        <property type="nucleotide sequence ID" value="XM_031717729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307462"/>
    <dbReference type="KEGG" id="aten:116307462"/>
    <dbReference type="OrthoDB" id="10435690at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031573589.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34612" checksum="C09A395E4811DAF9" modified="2020-12-02" version="1">MPTVHWRXAGTATVNLTIPERPEGHVEASSRNIKFPGCFIKNDXNLQYFVKEFIRDSADRNRLNPRNSKYVFYSPASVGYSGGVVTEAVISYEKISRKLGVDEQSTRTCTVNNPLVVSFYEHFFLFCDSQKLNESKFMENYSKEVRINQALDTSKRFYGLGMDDGQLQFIPFNMSQGQSRNNIYTISETSIYEKLKNAGPLLLDDNKTLVGYYRKRTGGNYRIEIDIFEKSQGDPPQDTSPGLQEGERAXHSPPPVRPERDRAPNLPPPGSQEGHPGPVPSPFGQQEERASDLTPPADNQQLGIITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2W5</accession>
    <name>A0A6P8J2W5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0160 protein MYG1, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574301.1">
        <property type="nucleotide sequence ID" value="XM_031718441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2W5"/>
    <dbReference type="FunCoup" id="A0A6P8J2W5">
        <property type="interactions" value="3375"/>
    </dbReference>
    <dbReference type="GeneID" id="116308081"/>
    <dbReference type="KEGG" id="aten:116308081"/>
    <dbReference type="InParanoid" id="A0A6P8J2W5"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574301.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41696" checksum="AB350ADE98E0B1D4" modified="2020-12-02" version="1">MFSRVFRLVWTRTIFKRIKSITMDTVASKKPHLGKKIGTHNGTFHCDEVLACSMLRQLHEYKDAEIIRSRDPAILGECDVVVDVGGVHEPDRNRYDHHQRSFKETMKSLTNSRKPWEIKLSSAGLIYLHFGHKVLGNILDLPENDPVTDEIFDKIYLNFIQEVDAIDNGVNQTDDLLRYEINTNLSTRVGELNPRWNDPNPNEQAQFNKALEMVEREFLNKVLFYKDSWLPARSLVEKAIKQRYEVDSSGEVIELDKAGCPWKDHLFELEKHLEVKKPIKFVIYPDNSEKWRVQCVPVRSQSFENRLSLLEEWRGIRDDELSKLSGIPGCVFVHANGFIGGNDTREGVLEMIRKTSEQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J376</accession>
    <name>A0A6P8J376_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307906</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031574092.1">
        <property type="nucleotide sequence ID" value="XM_031718232.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J376">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="GeneID" id="116307906"/>
    <dbReference type="KEGG" id="aten:116307906"/>
    <dbReference type="InParanoid" id="A0A6P8J376"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574092.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24184" checksum="C739DDEC65396260" modified="2020-12-02" version="1">MIGFAVTACVEAGVMVILYSVVLNEFAQRLRCPQYIDRNPHRYATYGYNNDDCYYRYYGYSYGYYXMSYSTAQTGAAICSLMLILAVVEFFVALASSIYGCNACCCTGPTIQARQQVAYIQQPGGNVLVVNPHGGMISAGTTVQTVSTYPGQVLPVMQNTQPQTFVTSPQGIPQHGQPMQAFQAYPASSQGGAGAYGVQQPQQAFQGPVNKQGDQPPPYNSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J416</accession>
    <name>A0A6P8J416_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Melatonin receptor type 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308152</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574397.1">
        <property type="nucleotide sequence ID" value="XM_031718537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J416"/>
    <dbReference type="GeneID" id="116308152"/>
    <dbReference type="KEGG" id="aten:116308152"/>
    <dbReference type="InParanoid" id="A0A6P8J416"/>
    <dbReference type="OrthoDB" id="6151005at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574397.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30519" checksum="1677F9C395972E53" modified="2020-12-02" version="1">MTATTPLGITLSITNSILAVFGSAVNLLVCIVIYKNEELQNGLDLLIANLCFADLSVCFIAQPMYVAYLNGKLSAETENAFSYISLIALHAVALNLLAIAVNRMIAIAHPFTNTFMFSKFKVLMVICAIWVSAIVAAVFLFTKPGKLFSPYSHIMIILTFLCCYARIFFIARKQRRQINIQMQSVSHNHQTVRLQKANRANITSALIVLSLMACFFPDTVYDFLPIEIMEVRKKWLFTLLFLSCSVNPCIYMWRTEVFKVAMKRTLRISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J597</accession>
    <name>A0A6P8J597_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116308541</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574849.1">
        <property type="nucleotide sequence ID" value="XM_031718989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J597"/>
    <dbReference type="GeneID" id="116308541"/>
    <dbReference type="KEGG" id="aten:116308541"/>
    <dbReference type="InParanoid" id="A0A6P8J597"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015378">
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <evidence type="ECO:0000313" key="13">
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            <dbReference type="Proteomes" id="UP000515163"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031574218.1"/>
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    <sequence length="332" mass="38407" checksum="3685E04507523184" modified="2020-12-02" version="1">MSNYSGNSQARVPVPEFHLWYYIIEGVLGFLTVIGNGFVVFLISTRRHLQVNHNFYIVSLALADFLLGISLPTFSILCSYCMKCDWLAFYKFFNFFAFSSVANLCLMTFDRYFAIIYPLIYINRMTKKVLIASVAIAWFVTAVLAMLPFIWMYDADKTIVKKYNDAYYLTLLVVFELIPLVTMPIAYFRIFNVVRKHSIQVTTQRDQLSYNNHQLEMKDSKESTTSSNENHGRNDEGKETKKKKSSIFPLDNDAGRSSIIVLGLVILLFSLCWAYDIYITLCTRVHLCRITNVHEEGISNILIYLNSAVNPFVYFLFKKDVRRELGACLKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J8Y5</accession>
    <name>A0A6P8J8Y5_ACTTE</name>
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        <submittedName>
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        <name evidence="4" type="primary">LOC116308024</name>
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    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAD8</accession>
    <name>A0A6P8JAD8_ACTTE</name>
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        <submittedName>
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        <name evidence="11" type="primary">LOC116308438</name>
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        <name type="scientific">Actinia tenebrosa</name>
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    <comment type="subcellular location">
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            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="46"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574713.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="41032" checksum="2060D300AD244363" modified="2020-12-02" version="1">MPAFNMSANGTIFQILEGGCFLNDALFIQIFRMIPYIIIIPLSILGNLLVIYIVYKDTSMRKTINYFIVNMSIADLVITIIYMPRVLTILLWGYIWLVSGPMANVLCKAVPFLYEVAVLSSILTVVAISLDRLFAVVWPLKKILTKTTCKVLMMLIWLVAMVSRWPIPYAVKLQIVKNDVYCFVYYDVVFSPGSDLLFYKVTLIIFYALPLTVISITYTAIMITLHRRKIPGSTPETTGQDLRIELLNRQVMRMVLVVVGSFVLCWLLYFITMVLRAIYLVDIPCDLFYMRLMLAHCNCAINPCLYVTLSENYRRGLMRIVKRVKGFCCMGSGRMPNERVVELGVSNTAMELTTNRGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCM0</accession>
    <name>A0A6P8JCM0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-binding cassette sub-family F member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116308101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574330.1">
        <property type="nucleotide sequence ID" value="XM_031718470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCM0"/>
    <dbReference type="FunCoup" id="A0A6P8JCM0">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="GeneID" id="116308101"/>
    <dbReference type="KEGG" id="aten:116308101"/>
    <dbReference type="InParanoid" id="A0A6P8JCM0"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000688">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058770">
        <property type="entry name" value="PWI_ABCF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26051">
        <property type="entry name" value="PWI_ABCF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="198"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="515"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574330.1"/>
        </source>
    </evidence>
    <sequence length="730" mass="82342" checksum="7CEC4FAF0C628819" modified="2020-12-02" version="1">MAEEVSQEVDSISMNGCEKSAVYESFLLDKFPTIDSDLLIYVKDVLQHGEDFENGNDIYDAVGGILHEVTSNNADDDEIKAICDQLMGIMKRSSSTEKFEHKKLDAPVILENTSLCADNEEEEAVSIWIKKQNDSTTVDQRKLGKAEAKLKAKQEKREEKEEKKPNVIVELDGATASQSGNRREAKMEASGTNKSRDIRIENFDLAFGERLLLKNANVSFAAGRRYGLIGRNGVGKTTFLRTLSRRELFVPSHISILHVEQEVIGDETPALESVLECDKGRYDLLKEERELVSQAASGSPECKSNGGATGRLSQIYVRLEEIEADKAPARASTILAGLGFSPQMQRQYTKEFSGGWRMRIALARALFSKPDLLLLDEPTNMLDLKAVMWLENYLQTWVTTILVVSHDRNFLDSVCTDILHMHSQKLDYYKGNYENFHKTREEKLLNQQREYESQQMYRQHLQAFIDKFRYNAKRASLAQSKIKILEKLPVLQPVAKEAPVMIQFPECEKLSPPVLQLDEVTFYYDASKVIFEKVDISCNSESRIAVVGDNGSGKTTLLKILLGELEPVKGIKHCHRNLKVGYFSQHHVDQLQMGQSALGMLAEKFPGKTMEQYRHQLGRYGVSGDLATRPLLSLSGGQKSRVIFSLMTNACPNLLILDEPTNHLDMETIEALAKALKNFKGGVILVSHDERLVRSMCKEVWVCGKGKVQSIEGGFEEYKRIVQEELKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JFQ8</accession>
    <name>A0A6P8JFQ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB/POZ domain-containing protein 6-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575145.1">
        <property type="nucleotide sequence ID" value="XM_031719285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JFQ8"/>
    <dbReference type="GeneID" id="116308796"/>
    <dbReference type="KEGG" id="aten:116308796"/>
    <dbReference type="InParanoid" id="A0A6P8JFQ8"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031575145.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48914" checksum="C61195BEACDEF42C" modified="2020-12-02" version="1">MEASSWQNKLSTVRERNLYAFNKSLFCDVKFSVLDSNGGRVTLQAHKYVLAISSPVFEAMFYGELAETGPTIDLPDCTKEGLQEMLHHMYSDEVSLNGSNVMQVLYLAKKYMLPFLEQKCREYLEEELKPEDVFVVLPQVKHLRDDKLEQHCWDMVDRETERAVSSEPFLDVPHEVLCQVLGRDRLKIREVDLFQAVDKWVLKRIKEKGIENKKKIKRSILGEEGIRLIRFPLMSLKEFAGNVLPSKILSTDEITELVQMFSSLAPSTKMFNEKSRIKASVFSSRFNDFSGDIWNYSGNIDAIDLTVNKAVSLVGVRLNGSQGNSYNVELTIYQIDTVLAFSSSSFQTEDKLIDDQYHGFTVTLDKPVPLDPGVRYTIAAKIQGPRSYRGDNGKESVQCEDLVIQYLPSTKSRNGTGVTQGQFPSIILELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GX96</accession>
    <name>A0A6P8GX96_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MAGUK p55 subfamily member 5-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548884.1">
        <property type="nucleotide sequence ID" value="XM_031693024.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286495"/>
    <dbReference type="KEGG" id="aten:116286495"/>
    <dbReference type="InParanoid" id="A0A6P8GX96"/>
    <dbReference type="OrthoDB" id="5859304at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031548884.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44128" checksum="7FF630BE4108EFBF" modified="2020-12-02" version="1">MASNKNMTITNQVVKEGLIHKKSTLLKQWRQRFLVLNRETLCVFKKERDQKKGRTAKERIFLIDITSFEKYTSKKRKFCMSILADGRSYHFSCASEIDRELWMRAITTAQNQEKELEENDPIRMKSMKLTGGLKRITIERQKGMGLGCTIKNVGGVIFVNRILEQGTVSSSGVLRPGDQLVDINGIELTGRSVAEISEIIRSSPEQVVCTVKLATDFRVVDTHVXPRTDYAEIDISSLKPRDDSESSESEESVHEDGHSSAENVNGNPETTEDDKITAKPPVKYEEPEYDDVIPGNLQKRHSSPLRHSPEESANTPNQPKNEEGNLNYLELNFPLYDRPRLKSEPINMPTTENKKPVAPIAAYAYIELDFKDKPQADEFTKLNVESVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GY51</accession>
    <name>A0A6P8GY51_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116286744</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549184.1">
        <property type="nucleotide sequence ID" value="XM_031693324.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286744"/>
    <dbReference type="KEGG" id="aten:116286744"/>
    <dbReference type="InParanoid" id="A0A6P8GY51"/>
    <dbReference type="OrthoDB" id="5986726at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JUMONJI, JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027745455" evidence="2">
        <location>
            <begin position="32"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="238"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549184.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="61555" checksum="F63F86FAB4C9E25B" modified="2020-12-02" version="1">MKLNSVTNRQLFEIFFLHIVVLSLRVNTTMGLEEKSIEVLEPNEKSIWFVRRSSSYTITWTQKTTAFRWXIRLLDSETMEKVLDISQSLSEYKDKEMSFSWLIPDSVSDGTYVVRVKDSSNDKNYGDSQPFSIRTQELDGFTSNTYNSFSPSSPHSPSLFTTLNSTQPEHLLPHEIKHARHLEEEEKRFRSINMEDYWPMPREHCTIQRVHRPSKEQFMKEFVKPKIPVIITGLMDDWEAMKNWNFEELGKHLTKGVKVDIMEIVDSDIRPSRFSFHMEPKRSGYHWRVETINGSLWSALILGYKRWGLYPPNTFFPPGVVHNKYRVQDSQSSEPFTWWAYTQPHLQADRQPLECVQRPGEIMYIPSGWWWSYINLNDSIGLKRWMCDEISLRSCLTELKEQADSGRHNYYADVFIQLRHYLSQHHSEILMVDDREFHSPISGLGKTFAELQDETSQREYQEYFGKYEIGREYLYDNGQEEETQDGNGREEQSQQEKRLESKEWIKQVKEARKKRNLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GY86</accession>
    <name>A0A6P8GY86_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent protein lipoamidase sirtuin-4, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116286776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549214.1">
        <property type="nucleotide sequence ID" value="XM_031693354.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8GY86">
        <property type="interactions" value="974"/>
    </dbReference>
    <dbReference type="GeneID" id="116286776"/>
    <dbReference type="KEGG" id="aten:116286776"/>
    <dbReference type="InParanoid" id="A0A6P8GY86"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01409">
        <property type="entry name" value="SIRT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003738">
        <property type="entry name" value="PRK05333.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031549214.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36640" checksum="E41669D69AEE3F71" modified="2020-12-02" version="1">MSFIIRRTIPYPSFNIIRLVRNAHKGSNLSQMAQFVPKCERTESELDYITNQLNEFILDYSKLFVITGAGISTESGIRDYRSEGVGLYSITNHRPMEYRDFLRSDQNRQRYWARNFVGWEEFXSRQPNASHFALNKLERLGFVHSLVTQNVDALHTKAGAKRVIELHGCSHRVICLNCHQVTSRNSLQELFYQLNPDWHAIGQGQAPDGDTFLDDKVVKEFQVPPCQGCGGILKPQVVFFGDSVPKDTVRQASERLKESNALLVIGSTVEVYSAYRFILQAKERKKPIALLNVGKTRADXVAHMKLSALCGSVLPRLDVLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYD9</accession>
    <name>A0A6P8GYD9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Receptor for retinol uptake stra6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116286795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549234.1">
        <property type="nucleotide sequence ID" value="XM_031693374.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286795"/>
    <dbReference type="KEGG" id="aten:116286795"/>
    <dbReference type="InParanoid" id="A0A6P8GYD9"/>
    <dbReference type="OrthoDB" id="2376984at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034632">
        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071939">
        <property type="term" value="P:vitamin A import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF15">
        <property type="entry name" value="RECEPTOR FOR RETINOL UPTAKE STRA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549234.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="31144" checksum="A5823F8EFE68CD7E" modified="2020-12-02" version="1">MHFLLFAVCTLIGIEIIEPLTRGKLDSFLYTMIXNIWPTILFSLLLFLSQYLMAKFVFLHDKGATLTLNNRRLFHIFTYFLFFFNIFLGVVSLLKRIIVCIAIWIMFLGRLQKSLVPRDYELCDPGYEAYLGYLYLEHTHSNPVLVTFCRILLVVVSRKTKFSRSSENFELLEVEGHPRVSFSFLYQERRSKRIRNRWALLMTLINNPALALDRRAEKFVSRLPLQALVNVANAYTEITAELIKRKKVKRRHEKDTHYEDEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1J2</accession>
    <name>A0A6P8H1J2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel protein Shaw-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116287039</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549513.1">
        <property type="nucleotide sequence ID" value="XM_031693653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1J2"/>
    <dbReference type="GeneID" id="116287039"/>
    <dbReference type="KEGG" id="aten:116287039"/>
    <dbReference type="InParanoid" id="A0A6P8H1J2"/>
    <dbReference type="OrthoDB" id="5961775at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18379">
        <property type="entry name" value="BTB_POZ_Kv3_KCNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily C member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="562"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="701"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031549513.1"/>
        </source>
    </evidence>
    <sequence length="775" mass="88873" checksum="E612FC043FC0208A" modified="2020-12-02" version="1">MGSKKRLEIMPQVIDTTQKRITLNVGGQKHETYLSTIRNYPDTRLYWVVENVTKTIDYHSEKIELFFDRHPGIFSLVLNYYRTGKLHCPNDVCGPLFEEELAYWGIDEKNMEPCCWTSYIQHRDAENNLKSFNVAGDFEAEQDEEREKSKGTDDESDRHSSRIFSLWSKYKPKVWSILEDPRSSRAAKIFSIFSVVLVVLSVAASCAITLPQFSEANTNLHVSRVIFDVIEYVCGSWFTLEVVMRVVFSPNKVKLVKSWFFWIDLLSVVPFYVRLLSPEGDNLADALQMIRLLRLFRFFRLLYGLQVLLHTLKASSYELFLLLIILLIPVVMFSSIIFYVEKKLDRFETKFQSIPASFWFSLITMTTVGYGDMTPNSWAGKIIGGVCAIFGVLMVALPISIIGSNFNLYYAHAQARLKLPRKKNKFHFDSLTTAMARQALRRRAMRRKSPRWSGSEDPLSLCSRANSTVKANNFELLAWDGIASRKCAATDQTNNEVKKPSNRLTNKQRKLSRERRMSRNDRPPAKLGDLPEHEENENGLKTEKLPTSRLSLGSSSLLHLTSEVPHRKVTDDRSYRSRSYSMPLSTQNTQYPRPPRKYRSDSSTVCEYCSLPKDELDRENLPFNSYELCQCERITEGHEQQRKSSSFTLIIPSPEGTEDWVEVSSESVNFKDAYNPTCRSFSINSDNYKSSQSNNVEIYVRDEDTPLRTYPPDSDGHSRDLDSSFSPSFGTRKSSDNSTVPLLIVESNDQDNPIDSACCGFNHTKMPNIEIETSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H266</accession>
    <name>A0A6P8H266_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EGF-like repeat and discoidin I-like domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549733.1">
        <property type="nucleotide sequence ID" value="XM_031693873.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="116287228"/>
    <dbReference type="KEGG" id="aten:116287228"/>
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    <dbReference type="OrthoDB" id="5981397at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
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    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FA58C_1"/>
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    </dbReference>
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        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="76"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="227"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549733.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43665" checksum="8F6972FCE483B01B" modified="2020-12-02" version="1">MYKSEKVKIINAWLSMQLLNTTTSTTEEEHEEYGTSREDTEDDVNSYEDTNEDTEDLDSDEETDIVTHEIGITDSCRFMFVGLSYPSIVPDHRFTASSYHDVRYKPSFARLSTSSKAWGPLTTSGAWLQIDLGSVVFVCAVATQGAGALNDEWIESFKIKVSLDNVNWDYYQENNINKTFTGNTNKDHVRTNSLSHPIKAKFIRMCPSTFNSWPSLRMEIYGISSTCSSPFGLEAPGVIQDSQMTSSSHIDNNHTASHGRLYGSSSWCSGNSNDTQYIQINLGKVMTVTGIATQGDHTMDNWVKTYTISYSMDGNLWNTYKAGGNNDKMLQGNSDKENVRMQWLSHTLTARHVRVTPQTWNTTICMRLELYGCDYGKYRHEILLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2P6</accession>
    <name>A0A6P8H2P6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Krueppel-like factor 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549868.1">
        <property type="nucleotide sequence ID" value="XM_031694008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2P6"/>
    <dbReference type="GeneID" id="116287338"/>
    <dbReference type="KEGG" id="aten:116287338"/>
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    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF150">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR LUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549868.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29064" checksum="22D957D0410EAD3A" modified="2020-12-02" version="1">MASSEESSTHTRTIQKRAKKTQDQACQFDSSLLEEETATCEACSQISCSRDALENCYSQPHVIQLDPEGHVQRTTVIRVVPADEDDYQQRSDSPLRYNSGRCNGKDSPPTVIVSPGDHIKEEYLIPTDEDYPSTHSPHIASDDGDSPTMVKDPRRTSELKTHDGMKRRRVHKCDYEGCTKVYTKSSHLKAHRRTHTGEKPYKCSWEGCTWRFARSDELTRHYRKHTGAKPFKCVHCERCFSRSDHLSLHMKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H394</accession>
    <name>A0A6P8H394_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288216 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550834.1">
        <property type="nucleotide sequence ID" value="XM_031694974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288216"/>
    <dbReference type="KEGG" id="aten:116288216"/>
    <dbReference type="InParanoid" id="A0A6P8H394"/>
    <dbReference type="OrthoDB" id="5969052at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550834.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="40841" checksum="611DDFA8214E11D1" modified="2020-12-02" version="1">MASKPVFTILCAFGMVVGFLTFIFGLIDRIGIQMQISFLMLPIWNGVLFGCAGFAGLIIGRQNRTQGYIGSGMTSGLKAINMLCFGLSLLTFYMYGSIVMYIGFRIEYNDELFYNYPTSATLLPKLLSTNDGTPVDDTRQGIFAMIILFSLVEMFIGAWIIMLEKEKMVLGSSSSSDQVPLVTNEPYQYIQQPQYGQPNAGMVVSSPQVRQQQQPVYMVAPGGNAPLPARAVVAPISQQQHXQQQQQPTFVVLQPSAVMATNQPQVVQQPQPQYVVMQNQVPNAPQAQIVAQEHFLEPSCLSIHQDPTDIQYLPQQDQPDVRRDTPSPQAGEVQSASCPSVNRLFALQSTPKSHVMDSSHDGIQRSGVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3C0</accession>
    <name>A0A6P8H3C0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288233 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550859.1">
        <property type="nucleotide sequence ID" value="XM_031694999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288233"/>
    <dbReference type="KEGG" id="aten:116288233"/>
    <dbReference type="InParanoid" id="A0A6P8H3C0"/>
    <dbReference type="OrthoDB" id="10339835at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027975978" evidence="2">
        <location>
            <begin position="21"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550859.1"/>
        </source>
    </evidence>
    <sequence length="935" mass="103182" checksum="C98EA096A4523AC7" modified="2020-12-02" version="1">MGNDLFHWILVGSLIKITGSVEIRDSKSGSKSCNLTLRFNTKPVFFTGYQSLEIFKHGNSHPDFSPLDCRVRSVKILRGFHGKIPLKTRFFTRIVTKKHNAKLEVILKHRDFKHLPVDEVFVLVELDCYGRRCALLSADTIKKRFTQSSWKTQRRKLLSFKIENSVHNKDFSLATPVLVAVAGIIVLIVSLAMCACGNTTHEKALSDEVGGAEADHHVVAVSSVTIEEDGQKTTEHKLXVKNENENSSNDRRNTNESKKSDRNSQSTTENGAVNSKGRAASQSSQPDKRSMGEVDSRPRNSGSKNSVENVEEVELESSAPENXTQNVTPEKQRTGSDKEAPGAGKQSKENNSSSEARTRTDSSEGAKKSFFRKPSRKRTGSNGKEPKSSPEENEEQKKSFWKRRKSSKTKGNVEDLENISTKKEKKKKKSGRQKNSTPEHVPSSSRPANIPLPPRPSSASVEEAQYDMVENHAQRPKQNLEDGDYETVTTSKTRTYDKINLLPKDQSRPASELYECINDQGANMKRLSSESNQYDVVETRIPPKKPANGLEYAVSVVASRDMPRIPTETSGGSGLYEVVTDDIKQQSGVLDARKSDIVVEDADYAVVQKGPSKKRASEKDDDERYSQVEKQRQKSLSGEIHHAPAPPPVSSLIHVSSTVRKRTQSEGDGLNASPLSDSPADPPSXQSDRPQTMFEVDETYAKVNLAKKKRHSAEVSHPGHAHEFAPATALPEGFDEDETPPPIPPSLYADLESVRKDDDKANDNQPSSSSTQPQTESEENAYEEVATKVEXKSITSRSRPTKTVSDLKITQSKDIRTENQTSLXSHEDPNGVLKRLKPPLGSPRNSDGRLSASSLEGEKRSSTGSHDYDEVLTKHAKPTQTDRSSTASKSSKDSASGHYESIVNEAKRNSAGSDVVSEGPKPTTSETDDRLVTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4J5</accession>
    <name>A0A6P8H4J5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550351.1">
        <property type="nucleotide sequence ID" value="XM_031694491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4J5"/>
    <dbReference type="FunCoup" id="A0A6P8H4J5">
        <property type="interactions" value="3561"/>
    </dbReference>
    <dbReference type="GeneID" id="116287797"/>
    <dbReference type="KEGG" id="aten:116287797"/>
    <dbReference type="InParanoid" id="A0A6P8H4J5"/>
    <dbReference type="OrthoDB" id="5981177at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000208">
        <property type="entry name" value="RNA-binding protein 27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="529"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="896"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="970"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="970"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550351.1"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115750" checksum="91FE232EA180A35E" modified="2020-12-02" version="1">MQIQNVEALKSWLTARLEPICDADPAALAKYVVALVKKDKAPEELKHVCIDQLEVFLSDETNKFVEVLFESLESQSYLPPSIVEPTKTPEKIRKPSVSDELNTSKLLADSSVPDDDERDFRRTRKNTDSSTSSGTKESQTTGDKGRKRRAEDEGGRLDEAKVAKDELGGSIPKKPDSDDTEVKRNGGSQSIPTSQASRESSTRERRYQNRRDFNSRSDDEGRFRRGGGPLWSHRGRGSDRGRDERSGRLREHRERDRHYDANQRFGHRERGGRNRCRDYEEKGFCIMGELCPFDHGNDPVVIQDMPMQGMIPGFPPAAPFIPGGPHPLSGLPVPPPILPSVPTAPPVQGPPNQPPPPGTIPKTSEGKDSPKGQKADSSKAGSEKETGPGPGLPVSSIQQPIVRPPPPVVMPIERPPFIPMHRPRPPFPPPEDSYNPEQPQFERFPVWMRIGTPGPGMPPVPYNPDLAMRSRELVNVPPSHSQLTVQVTTDKPSGESNRVVIGPEAVKQVSEQDQSNNTKPKAGWKRFNDTIELKKIPRELNNITKLNEHFQKFGNIVNIQVNAFGDSEAALIKFSNPSEAKAAYSCPDAVLGNRFIRVFWHQPDRENQPSSTKGSAQASAEAKKVPQKPTMFQSGKTTFVRQEKPAITAVTPAATAATTVATSTTVTAPTSESKEKPATVTTTATLTTATTTSSTTTSVVSTPATEMKTTVPPSKQQQRQDIMKKKLEIQKQKQELLDKQIQQQKLLISKLEKKNLSASEKEDIMKTLKSLSKNIEGIKKEIELAAMTAKSKQSPSQARELAKKAILDQELDLITYQHSGEDTSELKKKVEELKQEAKSLGLFDAPAKGRGISLLRGRGISYPRGRGQGRGRGRGHAMQSARVWTKESAALDMNLKQLCVANVKPEDKETIIEHFMEFGNVDRVEYEKDKSNLTLTFRTKKEAEIAFKAKKLKDRMLELSWKELPVPTPVVTTLPITPTASTPAPRSRSSTLSSSKLDEELALDLEGELEKHELDHDEDDEALLLGDDLDEEEEDEEDRSWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H532</accession>
    <name>A0A6P8H532_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287992</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550566.1">
        <property type="nucleotide sequence ID" value="XM_031694706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H532"/>
    <dbReference type="GeneID" id="116287992"/>
    <dbReference type="KEGG" id="aten:116287992"/>
    <dbReference type="InParanoid" id="A0A6P8H532"/>
    <dbReference type="OrthoDB" id="5984894at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550566.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="19163" checksum="5C6D67A3A62A893F" modified="2020-12-02" version="1">MNDRRITNVSSDPRDLEALTPNHILLLRKNTSLPPDEIKDVDKYKARWKHAHLLANEFWQRWTKEYLPMLQERQKWLREKANFKVGDLVLLADKNTPRGQWPKAMIQQTMPDNDGVVRQVIVKTADGEYRRDVRKLCMLEEELLKTKTEAEDQARSSPQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6N2</accession>
    <name>A0A6P8H6N2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC116288376</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7" type="primary">LOC116288376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551013.1">
        <property type="nucleotide sequence ID" value="XM_031695153.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551014.1">
        <property type="nucleotide sequence ID" value="XM_031695154.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551015.1">
        <property type="nucleotide sequence ID" value="XM_031695155.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551016.1">
        <property type="nucleotide sequence ID" value="XM_031695156.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551017.1">
        <property type="nucleotide sequence ID" value="XM_031695157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6N2"/>
    <dbReference type="GeneID" id="116288376"/>
    <dbReference type="KEGG" id="aten:116288376"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000025">
        <property type="entry name" value="Lysine-specific demethylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF37">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="144"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031551017.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="59164" checksum="15D66270D99A85C7" modified="2020-12-02" version="1">MMVYYAFQPFKQALALVFLFLSVFPLPGLLDSMVGHLQPFGSHWPPDVATQELDTVPHPREFWENFVKPRKAVVFRGAAKNSRAFHLWTEEYLISEYGNLTVRLEARAEENSKVPVGGQGILGRDTVEHFITNYQTMDAYVISQIPQPMEGDIAIPPCLRCGSFAESIQEVHLFLSAGGGKTKIHRDPYSTIHCVFNGTKDWLMIDRSQTDLLYMSEDSRFELGGYSYIDVDAVDLMKYPKIKDVRYSKVTMEAGDCIFVPGGLWHQVRSRGYMNTAVSIWFSRIYQFSDKGCDEAQIEFTFMNEVPVLWRFSGHGTLTQGHMDIYFIKWLLLTSSDKEGKINIKAFTDHYFVSNLEEESKKELMANDVTTRAKKFSEYIDPQNVGFITKEEVENFSIDKLKEIVLFFDPCDVSNTEDFEYSHIDAEQIMYLISQCKDSSGHFDSSKFIKSYVEELGGSPAKANKIVEDLDLNEVATIKEVERKAPQALKKYLNSHVHDPSFENKMIKQLMKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H751</accession>
    <name>A0A6P8H751_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase omega</fullName>
            <shortName evidence="7">GSTO</shortName>
            <ecNumber evidence="7">1.20.4.2</ecNumber>
            <ecNumber evidence="7">1.8.5.1</ecNumber>
            <ecNumber evidence="7">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116286228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 12">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="7"/>
    <dbReference type="EC" id="1.8.5.1" evidence="7"/>
    <dbReference type="EC" id="2.5.1.18" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031548547.1">
        <property type="nucleotide sequence ID" value="XM_031692687.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H751">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="GeneID" id="116286228"/>
    <dbReference type="KEGG" id="aten:116286228"/>
    <dbReference type="InParanoid" id="A0A6P8H751"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:glutathione transferase activity"/>
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        <property type="term" value="F:methylarsonate reductase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048353"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031548547.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25472" checksum="3E26DAD96E311CAC" modified="2020-12-02" version="1">MADSKPKLYASQFCPFAHRAWIALLAKKVDFEYIEHDPYDKTPEWMAISPTGKVPVIVHNGKQIYESAVCIEYIDEAFSTEVLLLPKDPYERAVARIWGDFLGKNITPHFFSALRKKTKEEQVEQLENFQNGLKKFLAAMDPNATFLQGETIGYLDIMLXPFANLLKVLKHYRDFEVPQSTEFSRFHKWWDAVKSHPALTPVMQIPIEKFIATYKTVFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8J8</accession>
    <name>A0A6P8H8J8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor SOX-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_031551558.1">
        <property type="nucleotide sequence ID" value="XM_031695698.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="transcription factor Sox-2"/>
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    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_box_dom"/>
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        <property type="entry name" value="HMG_box_dom_sf"/>
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        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF327">
        <property type="entry name" value="PROTEIN CBG16280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551558.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33960" checksum="D21353A7904A7399" modified="2020-12-02" version="1">MTTEPHIKRPMNAFMIWSSKKRRELAKENPKLHNSQISKILGTEWRKLGEEERQKFFAEAKLLNELHMIEHPNYKYRPRRRVKRRSLGRQGCGYSCFCHEHVXGLQSSRVERHEGSNAPMIKEIGTDEPNQNETEVNEDDLEARSTADEETEMETREVKTEEGTDNADSGIPKKGGKLLVSTAEVKQEEEKEEDEFNVFHASYSSFRPYTPEKRGHFVGSFVPSQLYWPTKCGRYTTLAAPATPPHVLCSCCSSSLVPHSFDARMHSFDWYQRERHSHRNSGRSHCHRNEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H994</accession>
    <name>A0A6P8H994_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ankyrin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290152</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553009.1">
        <property type="nucleotide sequence ID" value="XM_031697149.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H994">
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    </dbReference>
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    <dbReference type="OrthoDB" id="20872at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000009">
        <property type="entry name" value="Ankyrin 2, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF49">
        <property type="entry name" value="ANKYRIN-2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="10">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="11">
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            <dbReference type="PROSITE" id="PS50017"/>
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    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553009.1"/>
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    </evidence>
    <sequence length="1627" mass="179253" checksum="79298851698D036E" modified="2020-12-02" version="1">MKGRESSGLNQIDVAFLRAARAGNIDKVVNFLNDGGDIHTCNANGLNALHLSAKEGHLEVMAELINRGAHVNATTKKGNTALHIGALAGQRGAVEVLLENNASVNAKAQNGFTPLYMAAQEGHSDVVKVLLNHGGEQQVTTEDGFTPIDVAVQQGHDKVVALLLHHGARKGYRSLHNAARKDFAKAAKLLLQKGHSPDVEAPNGFTPLHIAAKYGNANVANVLIQNGASIDYKTKNYIIAPLHVAAKYGHLNIVQILVEKGAKVDIPNKDSLTPMHCAARDGHEKVVEYLIQKGASLTSRTKHGLTPLHMSCQGSHVKTSNILIDNKAPVNAVATNGLTPLHIAAHYGHVEIAELLLEKGADTDARARNGFTPLHVACKKNREAVIQLLLKYNANVHSANEGGQTPMHVATYYGNVTLVLILLQHGGSPDITNVRGETALHIACRRKQITIVRLLLRNGASVDAKTQDRETPLHIAIRTKNLEMTNLLLDHGASPDSVDKNKCTPLHIAAREGDEELVRTLLEHKANVNILSKKGFTPLHEAARHGHVNIVKLLLKYYETPDPEGKHGLTPLHVAVHYGHEDVAMELMDSNASPYAKAKNGFTPLHIASKKDQKDIAKSLLDRGVEPDTVTQTGISPLHLAAKEGNVEMCQLLMENGALPGIETNNGLTPLHLTARENRVEVAKLLLKFNAPINAQTVSGFTPLHIACVYGHWDIVELLLDSGADINAATKNGYQPLHLAAQYGHKIIIEILLQRNASPDALTNEGYSALYIAQTVHNNTTIVDILSKVTQITQTIRIKRRPGEEGDDEEPEIIFSAKPEELELEEVLEDMEKHEAEEEAPKEEAYDHFMTMEEMVEITDDSELKIQPGTGKKTDSGIFSTRYSGCFQEGTPLTGSHASDLDHSRYSDLNLSSGMQETEIITSVEGNLVQADLPSSLADMQEDNVQVYEPPVTGGFLVSFNVDARGGKMESSQTGIKVVLPPRSCQMPNRITCRLLRLNKPTLLPPIREGEGLACRVLEIGPTGTNFLQPIYFEVPHFASLRDNERELVVMKTDDGGWNWDEVCIEDNKDMDGYDDKNQDSIFPIKRYTKITTKDLPERFAVVSRLKKETFSVGQRGETMKSAVMPQVKVSIPEGAVSAGTKITMQVQPVDENFNNLEEWVTVSPVVSLEPSNITFNKPVSVAIPCPVYAGAGNVDIQPSLRLLCCFPKDIDGEPKTPSYQWQDITDSTPLTTAGDSATFTINKPARYWLVETRNPDNVVTDARLIYRKLAAVPYLAKFVVFAKFSADGREARLRIFCVTDDKVDKTLEGQTGFVEVARSRDVEVYEGRPIHIRCLGNLAPVNREPMHLNFFAFRENRLSVAVSAVDPEQPMNCRLAFLKEPKKDRQGNIQTICNLNINLSEKDLKKDSGLRRLPDSLLSLVAXEVANDWKXLGRELGFNDDELDDIADSNSNEPDKCAEEVLKTWRDSKEPEPDMPKLENALKNINRDDVDFKQLAYSSYSKGPVTITETTITRTVPDERNGDVQNTHERISDYLNDDDEEMSDAAHTEVRTVTVTDDDGGAVTRTTTTTVTRDGETVETTTDTREGDENDPDKEKLIKEMFAGEKGVMDFFNDDDKKPETDETEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAQ7</accession>
    <name>A0A6P8HAQ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Laminin subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116289896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552696.1">
        <property type="nucleotide sequence ID" value="XM_031696836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289896"/>
    <dbReference type="KEGG" id="aten:116289896"/>
    <dbReference type="InParanoid" id="A0A6P8HAQ7"/>
    <dbReference type="OrthoDB" id="6020644at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000034">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF406">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028476215" evidence="12">
        <location>
            <begin position="22"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="13">
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            <begin position="287"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="13">
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            <begin position="335"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="13">
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            <begin position="381"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="13">
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            <begin position="427"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="13">
        <location>
            <begin position="514"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="13">
        <location>
            <begin position="560"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="13">
        <location>
            <begin position="616"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="427"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="447"/>
            <end position="456"/>
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    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="514"/>
            <end position="526"/>
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    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="516"/>
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    </feature>
    <feature type="disulfide bond" evidence="11">
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            <begin position="535"/>
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    </feature>
    <feature type="disulfide bond" evidence="11">
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            <begin position="586"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552696.1"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121105" checksum="B80E923F4AD1C6BF" modified="2020-12-02" version="1">MLVVYLFDLVFFVLSFSLTEGYHYKKLLPPQFSITKTPKVKAVVTFGDGFSRKISHSLGLSKATSNDFSSIAHALDGNISTQWKSPGVTRDSITQELNITVSFGQDFXVTSFTIRAGNTPLPGVWVLEVWNPXRRQFQVWKSYVTRPLECRKHNRWTCVVRRKARFSEHVKVPILTSKLRLRFLQIXSMESPIAYYSIRDLNVKGRCRCNGHADACVLSHDGLMKCACQHNTCGRNCERCCRGSXKRERKKXKSFSCKKHSVVSSRDNTNASLSSMQGDQGIPDQLCFCNKFATRGMQCNPVSFNSGCNCLPNYRGRRCESCMPGYYGFPNCLPCKCNSEGSTNLVCNQKTGRCPCKTRIRGTKCDLCPLRHYDFPRCRPCLCSKTGSYSFLCDAKTGQCSCKDGVYGRRCNECPAGYYNFPLCWWCNCNLKTTTDDVCDNNGKCICKKNFMGESCDQCRPGYYGYPQCTECDCRSGFGRCGKVGECICFKGYTGRSCDRCADGYYGFPHCLECGCDAQGSYSSTCDSITGICQCKLNVIGKTCDQCAAGLVGFPSCTRCNCNPTGTKVGDAGSTCIGVSEVRCLCKKNVMGKTCDHCKYGFYDFDSSNADGCLSCACSSRGTASGIRGCDEITGKCSCKDRVGGKKCXTCINGFYGLVSQDMFGCKDCSCNPGGSVSRVCDKATGRCRCRPNVEGINCDRMPKDSKTYFPNLHHIRAELERAVGDDGIPVLGSSDQAAFPSFSGSGYVVSPKQKAILMDIQVPRSSVYRVIFHYALNNGTSVASEIILSPKGARDPTHRIVHTFRPTSYSGGAQTKFVVLAENGKTAEWELKKGMWTVSINTGSSDLLMDYVALLPEEYYTGSVLRFVSTEPCEVRKYFNKQCSMHKYYTTSDPDVVTIQGSHGLQGNGFPVLSFDEPKFALNRVSYGNKMALLGRSQLSISYEIQVKQAGRYILVIKYLQPDRNVRRVNVLHEQSRGLFEALPCVYTFACLHAVINGMGQPMVFELQGNLFRNKISLSTTQAAKIGIISLTATLETKWNVSHIKPFFYCHSHGYTCLRSSYYMPKGSSTMMGPGLRHIPSRDRKVWLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB40</accession>
    <name>A0A6P8HB40_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein PB18E9.04c-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553684.1">
        <property type="nucleotide sequence ID" value="XM_031697824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HB40"/>
    <dbReference type="GeneID" id="116290723"/>
    <dbReference type="KEGG" id="aten:116290723"/>
    <dbReference type="InParanoid" id="A0A6P8HB40"/>
    <dbReference type="OrthoDB" id="10608042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553684.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23345" checksum="750AB03030729970" modified="2020-12-02" version="1">ASSFIPVTTAATTLPLSSATSASPTVSSTAEIKTTSHPPTPVTTTEITSFSPYTSSSKVTSEIKTTSHPPTPVTTTEITSSSPYTSSSKVTSIPTNNTGTHLHHHGNIMLLLYTLLPTGGLVLVLALMIGVMMVRRRRKRIAYSRLTSLSIDEIVPESNDTSCAVTSDKQVDTDTSTRLKLMDTTEHTSSDSDDEMIRLDRNPPGFPNTELQNVSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC93</accession>
    <name>A0A6P8HC93_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="10">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.1.3.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031550130.1">
        <property type="nucleotide sequence ID" value="XM_031694270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC93"/>
    <dbReference type="FunCoup" id="A0A6P8HC93">
        <property type="interactions" value="1766"/>
    </dbReference>
    <dbReference type="GeneID" id="116287579"/>
    <dbReference type="KEGG" id="aten:116287579"/>
    <dbReference type="InParanoid" id="A0A6P8HC93"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051998">
        <property type="term" value="F:protein carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="11">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550130.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="49874" checksum="0B6DC78CD566343F" modified="2020-12-02" version="1">MSSERPEPLSGKDEGSYAYLTIRDRMPTILTKVIDCIHRKATEYTRENKQEHAQDARDIVGRLSKLNYEMKTNKKLSMVEDTKNDAHLWNEFLKNATSLVDGSKISWFSGAWLTCECFMYRKIYEALALSKLHQDFDPFREQKQASFMSQQDNIASLANILVASLDAFSESSISKTQELHFEMFLQFSLWGNKCDLSISGGEVVAENAGLSLKLEDLRKHILVNNTSRIWQTLQDQSNQRIDFILDNAGFELFTDLCLAETLLNLNKAQVIFLHLKDFPWFVSDTTQEDFFWTLKKLKESDVESLSKLGHRWEERIQNGSFVLKKHFYWTLCHDFSQMKSTASELYDELAKSKLLLFKGDLSYRKLVGDRKWPHTMPFAEALWGFYPAPLCALRTIKAEVVVGLEEGKDDAVEAVDKDWMITGTYAVIEFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGA2</accession>
    <name>A0A6P8HGA2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anosmin-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555434.1">
        <property type="nucleotide sequence ID" value="XM_031699574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292291"/>
    <dbReference type="KEGG" id="aten:116292291"/>
    <dbReference type="InParanoid" id="A0A6P8HGA2"/>
    <dbReference type="OrthoDB" id="9985779at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042447">
        <property type="entry name" value="Anosmin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131">
        <property type="entry name" value="ANOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14131:SF5">
        <property type="entry name" value="ANOSMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027679743" evidence="1">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="265"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555434.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53492" checksum="1B13B648CFC61193" modified="2020-12-02" version="1">MASKINRLPFLLCIFVTLVECRMREIFSARCQARCFAKTLNPSRPCTGSCFTACIKPCVDHENFHKVKLCREYCREFKVKNDNWQCRHSCKYLLNLYNKGLKSGLCQDFXNTQSCGTTSCENDNVCPDLEKCCQQPAGCGKTCQIPSFNVTGYPSTPTTVNSTFIKRPRSVVIKWSYMHRDPRPQSEEKAVIFMVEVRHISIGSQQGVVSGEWSYFNMTKELHLTGYPRSNVWSEYRVLAVTEQGTSEYSTPSSAIYIPPEKPTPPRNFRVRMMAAVKGKVRLELVWSKPEKSEVPMHRYRVFWSKRLDSHTEELMSLRVHHLKINPDQHSALINGLRFNTTYLFEIQAICRYKGQRLRSSRVYLTARTMEQEEPDNKEALHKKIGKVFSNSFKKPEIDKTTKTYPSGRTWTPPTTSSVVVGRPENVSRRPDAEANVRHTSSSNYIHPCLSLVLWLVLFHGLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGC8</accession>
    <name>A0A6P8HGC8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC116291035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116291035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554018.1">
        <property type="nucleotide sequence ID" value="XM_031698158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291035"/>
    <dbReference type="KEGG" id="aten:116291035"/>
    <dbReference type="InParanoid" id="A0A6P8HGC8"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="12">
        <location>
            <begin position="537"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031554018.1"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123220" checksum="6DF73DCB425093A5" modified="2020-12-02" version="1">MPLGLSTQEIPDXQITASSSRGSDSPHFGRLYNDKYWCAAQTKNTEYLQIDLGKVQTINKIGTQGRRTRNDWVNGYFLEYSQDGKRWTKYSESGNSVTSNSYCFSGKCAETRDTQCRDLWGPDSNNANQGCYDKLNTEAKGFGTCDPVSNSSCATSNVRCGQIQCLSNRNTPVEDYGKTYQKFTLDASTQCSAAVLKTNSDFLGLGMVNDGTKCGDQKMCSNYECKSFAELNIKPCQTVNGQECNGQGVCTNTGVCHCDAGYDPASACVNALIPRDGGYGAWSAWSTCTAGCNGGTQNRHRFCNNPFPTHGGKDCQGERQQQRDCNTDACPRAHSCRQLQKIATTENKYIPDGVYAIYPYGVDKDPIKTYCDMSRDGGGWTLLVTSHTNSWTSQNVRLRNQDSPSLTSDYSILNYADDIKNNLNVVGSKFEYRLEAQSRGRWGGIWEADRSYTFTATTNGQTNVQLIKKFDNWNYANNGIEKRMPWISGAKLTTSAKANSNWWGTITANEKSYHPAPWIRGHFMEQQPEYIWYWVREGPWKLPRSCMEVQMRGLQTTPPKDGVYSIKPPGKKEVKTYCDLASQGGGWTLLVTSKTHTGWSVDNVKNRNSNQPSLDADYSILEFADAIKDFDVSQDSFQYRIEADGSSQYGGIFVAPREYTFTSTRDKQTNVKMVENFNGIDKNTNLVRRMPRLALSANIFLSSGSIANDSSGSIIYADGSAESPSYLPDVKPNPGVVRYWMREGTRRSCNDIKVHGTRLSRKYEDDYYMIRLVNESTYFPVFCDMTSDLGAFTLVVTSRHNNWTRDQVPARNVYRPSTSDDYSILKYADLIKNMGHNTTFKYKLDANQRGHWGGVWSAPRDYSFMFTSTSQTQVTLLQKFDAWTLSXWRSVQNRMPWFDANGQSNKALLTTSSSTTYYPAGSIIWGDTDRHPAEWIRDGGMINPGVIWYWVNEDDCDLDRQPVDGGLSEWSAWEKCDKLCADGKQVRRRTCTNPEPRCGGLLCSESEKTVEEKPCYTCPESPIRSYGGYCVQPKSGDCNPKENTTTWSHALVFRRVDANCSADYMNFVFDADGMIYHKCSGKIVCPDDTQKKFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGS2</accession>
    <name>A0A6P8HGS2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptor moody-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116292433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555614.1">
        <property type="nucleotide sequence ID" value="XM_031699754.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HGS2">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292433"/>
    <dbReference type="InParanoid" id="A0A6P8HGS2"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="12">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031555614.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41505" checksum="0AF6FDD9DFF5FFB4" modified="2020-12-02" version="1">MDNQTFIERLRQQLTTRGVAVVIVESFFMILINXTTFFGNLLVLLAVFRNPRLRQNILNWYIIGLAMSDLLMSLLGIPYSAASTVTGSWVFGHFLCQGQGFFVLLLCAVSLQTLALTAINRYFRTTRSNAVYSKYFTVKSTKITIAVLWIAAFLAPLPYVLMGQEFFFHPGKVFCTHNFDTLVGGYGAVLVLAYVTIPFVIIIFCYSKVLICVRRHNSNFRVHASTDNESTSLRLSVEEINITWTLMAVVFGFFVCWTPVVVIDLIDFVNGDWKLPRQTYLSYTCFGFSSTAINPFIYGVMNRQFRVEYYKILPFIKTCTSRGSLNAIQSAGIDDAEKRKPSQLRNTQDAQELKMGTKAEVVEIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJH6</accession>
    <name>A0A6P8HJH6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116293267</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116293267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556534.1">
        <property type="nucleotide sequence ID" value="XM_031700674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJH6"/>
    <dbReference type="GeneID" id="116293267"/>
    <dbReference type="KEGG" id="aten:116293267"/>
    <dbReference type="InParanoid" id="A0A6P8HJH6"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF161">
        <property type="entry name" value="LAMININ G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027998509" evidence="8">
        <location>
            <begin position="24"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="9">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="10">
        <location>
            <begin position="211"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556534.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="45171" checksum="9B9E51DE593DCA5B" modified="2020-12-02" version="1">MPSKTVLVLTTFYGALLLTAVSANGGCKTIAFNEKIKGKALKNHVFQTRESGSHQFCRVLCYLDNRCLSYNYGTSVNGDKEMCELNESDHVMHGEDLTDRLDTVYFRVENDCNCPKNKICRYNFVDSSHYCECKTNSAPGTQCNVTEPSTWSPIGSPTASLTKVSTVSTTESQTMTGSPGGTTTASPGGPTKQSPTTQSTTQAQATTVSSSDCELQFGAASIHNMIKITNAFTTTLQMFTISFWLKVPSSSLTLYPFSYATSSETSAISIAIKEDGVMEVGANGGGKGIDSFLQRNNVWQHFAVTWESSNGNVKLYYNGGQKSSTESGMAQTKIIPTGGILIVGQYQGELAGGFDDTKTMRGNIAGLNFWSSEFTADQVTELYKQSCGAPSGDALSWVMILAGKIRGDLQKMCPTTCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK79</accession>
    <name>A0A6P8HK79_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556779.1">
        <property type="nucleotide sequence ID" value="XM_031700919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK79"/>
    <dbReference type="GeneID" id="116293489"/>
    <dbReference type="KEGG" id="aten:116293489"/>
    <dbReference type="InParanoid" id="A0A6P8HK79"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031556779.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37501" checksum="707F71F10081FAA3" modified="2020-12-02" version="1">MSYKDTKTFLSVLFGVLAIINLTGNILTCIVVKRIISLHTPMYYLLVNLCVANIIMAVLSAAMYIFSPVYQHPSGQAGDYLCKFITGETIFWIGGFASGFTLVLIAYERYRAVVYPHDLSTRLNLKRLKIALAISWICAILLNLPNFSTIKVYEVSKTIRVCKEGWEGNTTGKVWSVILVFISFICPLSTVSVLYSRTVYHLYKRQRQIIDVSQMAVTKVRKKITIVLIAITVLFAACWTPDGVTYIYIHFSKPSTEDSLRGIPIIREVAILLVCFNSAIHPFLCAFTSQEIRRGLKKIICRKKDLLANRPHLQRTSRRLTISLNATKMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKJ0</accession>
    <name>A0A6P8HKJ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116292266</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555408.1">
        <property type="nucleotide sequence ID" value="XM_031699548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKJ0"/>
    <dbReference type="GeneID" id="116292266"/>
    <dbReference type="KEGG" id="aten:116292266"/>
    <dbReference type="InParanoid" id="A0A6P8HKJ0"/>
    <dbReference type="OrthoDB" id="10651441at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028175191" evidence="2">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555408.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28752" checksum="A2C971BB8CCC6B0D" modified="2020-12-02" version="1">MKLKVVVTCLAVILFFFTPVDLKSVTKQDVQDQEEKQEQSVVKTVSEELQGSGAGKEEEDTVDCDEEKLKKCNILCKKSKAVEKRSTHNDKTCECSRQMCKNEDPEKRRKECDEKTKCDDKTRCKKCASHFHATGGKKEGNCTCSKKASSPVMQRVFSFPAIMIAPIKGYNTPEKEVQGKKGTASKKCCCHDCCCCCCEPCCCCHECCCCPCCCCCCEPCCCCCDCHHCCHHCCDHCCDHCCCKKSGAQGAIRPGPQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL66</accession>
    <name>A0A6P8HL66_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoside diphosphate-linked moiety X motif 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557144.1">
        <property type="nucleotide sequence ID" value="XM_031701284.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HL66">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="GeneID" id="116293803"/>
    <dbReference type="KEGG" id="aten:116293803"/>
    <dbReference type="InParanoid" id="A0A6P8HL66"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557144.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43784" checksum="5B7B7EF62C079255" modified="2020-12-02" version="1">MSRPPHQLWRNAATLMLIARSSVPRTPFNYRILLLKRSSKSRFMPNRYVFPGGVIDEADFSEEWLDLYTESSNGSDFSSLVNMKNPRPPIFKISNTTIPSEVALRICSIRETFEESGILLLKKMSKDDNVXTQGCCEVYDHHSKGEIQKWRENVHNDPTKFIALCRNLKSVPDIWSLGEWSNWLTPPDIKIRFDTVFFICFVDYXPVSQHDNKEMIHSQWKMPIEGIVEYYSKKSNIGAPQMYTLLQLCRTTKWEELKAFQEARANEGFNRWMSIRLNCANGAIGLLPGDDLYPMALDYVAKQTNGDYGVRDGPVPIQQLDETMEELQARTKNHNRFCVSKSKVPRFKILVNCSLEKRALPPVCDAGEIQKLARQLEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLK0</accession>
    <name>A0A6P8HLK0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116292618</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555828.1">
        <property type="nucleotide sequence ID" value="XM_031699968.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292618"/>
    <dbReference type="KEGG" id="aten:116292618"/>
    <dbReference type="InParanoid" id="A0A6P8HLK0"/>
    <dbReference type="OrthoDB" id="5977572at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="130"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="282"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="434"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="549"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="646"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="741"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="835"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555828.1"/>
        </source>
    </evidence>
    <sequence length="966" mass="107065" checksum="1FFDD5692BD8C871" modified="2020-12-02" version="1">MVKRVETARLQDVVQNISDHRRKYLQEAKLQPQVKFVLNPVSAKTDDNNDKNLTHVQGREYEYSQPRQHRVQRLTETKSFAGDFDSNTTVKNLLYDGTVSQYIRVAPTSHYGSTSCMRTELYGIKHDGVCTSMFVGLSYSSIIPDHRFTASSYYDSRYEPSFARLLTYSKAWGPRATSGAWLQIDLGPVVYVCAVATQGAGADLQNEFVRNYKISVSLDNVNWNYYQEENITKVFTGNTDRTAIVTNKLKNPVRAKFIRLYPTHFRSHPTMRAEVYGIPSACSSPVGLETPGLIQNSQMTSSSNLDNSHTASYGRLYGNGAWCSSTSSNTQYLQIKLGQMMTVTGVATQGDHTMDKWVITYTISYSMDGNLWKTYKAGSNSDKILLGNSDKDTIVVQWLSHPVTARHVRVTPQSSKTAICMRIELYGCAYVTRPVISGLTNQNLTAASNSYVDLVCIVQEPLIQYIKWYTGDTDITSQSTGMVRGANGVKNSTLRVNYTSADDVLNNYYCHDSVCSKAYVCRTMYENIKTTADGIRSAGVTIKLDYPSILAVPTVHDIKSTSVTVRWIQPALNASQASVTTYLLQYQNITHTQTISVSAHATSHVITGLAIYTNYSVQIKTISGVGFGQWSATTNFRTLPAIPVGFPNSVTAVAKTSQSILVTWQAPTSGINGPLRGYRVFCRSGSDKHESTATPQQTSHTFSGLRKWTVYNVTVVIHNDKGDGPIHSYVLRRTLEDAPGQSQSFQVTVLNSTDVRLNWALPSERNGIIRGFKLRYEKADSLSEKDLPGNTTLSYVLTGLDKCTLYSFKMLAYTIKDGPYTSVILKTTAEDAPSAPDILKASIISPNGPSVPQVTLTWSKPAVCGDNIRHYKVSYNHDVDPTLKGETVDKSQLTITIPVWGGVTYEFRVRGVTNKEGLDTPTKTVVIPIYSPSVSPSNXXFSEAXKTTFXXXWXEIPRNLIEKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLP3</accession>
    <name>A0A6P8HLP3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hemicentin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553567.1">
        <property type="nucleotide sequence ID" value="XM_031697707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HLP3"/>
    <dbReference type="GeneID" id="116290629"/>
    <dbReference type="KEGG" id="aten:116290629"/>
    <dbReference type="InParanoid" id="A0A6P8HLP3"/>
    <dbReference type="OrthoDB" id="5989413at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF219">
        <property type="entry name" value="TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027981638" evidence="6">
        <location>
            <begin position="29"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="50"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="137"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="252"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="339"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="440"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553567.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61398" checksum="4CC661C1A64F89DE" modified="2020-12-02" version="1">MKTSKSQWLSCSLLFIASLSCMPGKSSARKVSDEFKFLVTPKMFYAVPFGSNFKLSCTTNDETATTQLYHRQSIGSAWNLLSPTPGKLIKSGQVYTVLGFGISNAGQYQCRATNGSGTTIKWSDRLANLIPNPSLTPPLDIHPRRAVVLTTGQSYNVTCSSVPQSTLKWFKKYTDGSETAVPSNQIHTEKDLEINKLKVVLMFKNAQKNDAGIYICKMTYQGKGDFKYSTLEVYDRFKFRRQPKRFSIVGFGASLTIACTTNELNADVSLYHRGSPSKPWKQLVPDMKRVFKNSQTFVISNFGISDVGHYQCRGRNRRGNTIRWKEGSGIVLAHPILTPPVTIEPKHAVVLTEGQSRNITCTSVDRTTLQWFKELANGTIIPVPTSKTVEKRDRNKFSVILMFRDAKKKDSGSYKCLMTFQGRRSHKYASLTVMDKGTSPHLKGRKKMLSVDETSRVVMSCNAKGDPLPNITWYKGSNLINCLSNGKPCGPLLQYTLKNRIKTKNTSKIVRSQLKISRTNRVRDQGNYICVASNKHGVAHRSYQLTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN08</accession>
    <name>A0A6P8HN08_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC116291057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291057</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554040.1">
        <property type="nucleotide sequence ID" value="XM_031698180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291057"/>
    <dbReference type="KEGG" id="aten:116291057"/>
    <dbReference type="InParanoid" id="A0A6P8HN08"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028101718" evidence="8">
        <location>
            <begin position="29"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="10">
        <location>
            <begin position="31"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="11">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554040.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46339" checksum="EB9811FA219609D9" modified="2020-12-02" version="1">MNVFRCQLKLDEILLLVLQITLITQSSSQGCKNMAFLQHKPGXYLRNHVIQTVTTTSQTMCRITCYLSDSCVSYNFHESTGTCDINDSDAFQHPEDLITRPGYVYHGTENVCKNKPCPANSTCRADFTYDGGFSCLCRSGYTGSSCSEDIDECASGTHNCSAYSRCQNTEGSFYCIKLVLGSKERPAKSCLDILTNGFSNGSGVYLLDPANTGNPIEAYCDMTTNGGGWTKIKRLYLESPSLPQNQGYNNYRIIGQYNNNNRSIIPTSKALLDIHQKMGFHQIHFYCYKKSVGRVVSIMTKNDTAGQDVIHFFTTREVSVFPTACGSFDRLPEDTSILAQNCSLWGEINSTTIQVDKWGNYGYRHGQRINNYPFGIEGDNKHLFSCHSQGPSNMRGACDDSGSPLKINDTWQIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPB0</accession>
    <name>A0A6P8HPB0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557471.1">
        <property type="nucleotide sequence ID" value="XM_031701611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPB0"/>
    <dbReference type="GeneID" id="116294080"/>
    <dbReference type="KEGG" id="aten:116294080"/>
    <dbReference type="InParanoid" id="A0A6P8HPB0"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000026">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="10">
        <location>
            <begin position="173"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557471.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42121" checksum="14D04F97A655C8CD" modified="2020-12-02" version="1">DEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTVGKEHIDTVLDRIRKMVDQCVGLQGFLVFHSVGGGTGSGFTSLLMERLSVDYGKKSKLEFTIYPAPQVSTAVVEPYNAVLTTHTTLEHSDCAFMVDNEAVFDICRRNMDVERPTYTNLNRLIAQVVSSITASLRFDGSLNVDLTEFQTNLVPYPRIHFPMATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSYDEEEEDAGDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPL4</accession>
    <name>A0A6P8HPL4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116291545</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116291545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031554582.1">
        <property type="nucleotide sequence ID" value="XM_031698722.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291545"/>
    <dbReference type="KEGG" id="aten:116291545"/>
    <dbReference type="InParanoid" id="A0A6P8HPL4"/>
    <dbReference type="OrthoDB" id="5976830at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554582.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="50596" checksum="F3CDB2743BCD5FFA" modified="2020-12-02" version="1">MARYVPIRGGSYVPLPAWIERKKAIVSVKNDDNKCFQWAIRSALYPVEKNTARTSNYPTDDLDWTDVSFPMQLSCIPDFEERNDLAINVYGDREETIVPLMLSKHTGERIHLFYHGGHYSWVKNLSRLFYRHTKHKCKKFFCESCLLPFPDLKALKKHDEICRGVEEVAQRIQMPAEKDLFYEDFKRQSXVPYVIYADFEAIITDEYQESGNTQRKGLHEICSYGYVVVRSDGKADDPVIYRGKNAAALFLEAIKEEEEDIRQRLRTTKQPKLSKAEQAAYAKSMTCHVCKHNLLQFGRRVKKCWSDDGAYLGEAHPKCGKYARKGEKAGKPTTHCIHCKKPFEEDFYVDKVLDHCELTGAYKGATHWRCRNKIDSNMDIPXFFHNLRGYDSHLLLQGVDGHEVKCIPNNKERYMSVTIGKLKFLDSHPNNLWQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQB7</accession>
    <name>A0A6P8HQB7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Polycystic kidney disease 2-like 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558564.1">
        <property type="nucleotide sequence ID" value="XM_031702704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295006"/>
    <dbReference type="KEGG" id="aten:116295006"/>
    <dbReference type="InParanoid" id="A0A6P8HQB7"/>
    <dbReference type="OrthoDB" id="5990039at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="12">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="11">
        <location>
            <begin position="183"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031558564.1"/>
        </source>
    </evidence>
    <sequence length="649" mass="73479" checksum="BF8B0CED3840BC95" modified="2020-12-02" version="1">MYINDKRSILIGMPRMKQNRVGKGHCTIPEKVTSIITTCVAIYTMSREDKTKVNLPGWGAVKYVNVSSNATILTPETCPKPWRYHTASEISSLPYWGRSTVYGGGGYMAXLGYQPGIAQRVITDLQNSNWVGPRSSAVLVVFSVFNVNTEYASFLSFLYEKLPTGNGIASYKISSMPLYPASVLFLTFQLLFLVFVLFYLILLLVKIFKKKLSFFKDPWNGVEIFIIVFSIATVILQLLKGMYTSEIIQKINQNPYGDLSFDYIVLATDLEDTLMAFLMFFSTIKLLKLAKLDKNILVISSSIRISIRDLVPQSIIFIVILLAYAQLGMLVFGPEFESFSTFYNALVAELQMFIGGNSEIWILRQNNRVLGPLYIMSFMIFMGWIMMNIFVAILNDVQTSQKQNLGILEQEMQLLDFIAKKAKSLFRISSAEGHKSSRIMPEVVVEESRSLNERAAAETIKIAPEEATETTTNNNDILQVTPKRKNQKSGYQKLRKERSKNTDPSIPRDFSVENVICLHERIRKINVFLESLEMDVQSEDLQITRLILELESRCANHSSRSTSITSLSATTASRRPSYNHPRKASSLLSEVTSSSQDNAEDDIRLVFPRPNPHADKNYHFRPVVLGRIATERFSNAFSTKGNIKDNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQK7</accession>
    <name>A0A6P8HQK7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC116291859</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031554936.1">
        <property type="nucleotide sequence ID" value="XM_031699076.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554937.1">
        <property type="nucleotide sequence ID" value="XM_031699077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQK7"/>
    <dbReference type="GeneID" id="116291859"/>
    <dbReference type="KEGG" id="aten:116291859"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF6">
        <property type="entry name" value="HEAD-SPECIFIC GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="10">
        <location>
            <begin position="429"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031554936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554937.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="78799" checksum="BE1D1B54E92A4C8F" modified="2020-12-02" version="1">MQLERINDVLRQFVIDKHGTDAWNKARAKIGQVIQEKTKQKATNDVTNPKTHFGDSLDFAREIINAVSQVLGKNIYDFQEDFGRAAFMICLQMPQGKILQSLGSSLCEFLNNLDNFVDIFIQANELRDAKPPSFKCIVKDDGQCLELHYYSVRHGWESCVVGAVKCAAKVLFNLNVIMTLVEDTDVEDHSNGKMDHSVFEIMKKRESFAVKKHAHSTNPNDLKISVPTLCSAFPFHIIFDEKMEIQQLGVALLRLIGHSLVLHGTSMATYFELVRPEVKFTFESILCRINGSFLLLLKSETQSEHVKDKLVMELKGQMIHLPESNCVLFLASPLVKKLEQLKGRGLFLSDIPIHDATRDLILVSEQAQAQDGLKKRMEQLQTELEVASNELEEEKKKTEDLLSSIFPQDVATKLIDKQPVPARFIENVTMLFSDIVGFTSICGKCTAMDVVEMLEHLYTKFDKLCGELDLYKVETIGDAYVVAGGVESLYGTDDDAYKVAKMALGMMDFLENALSPEGLPLKMRIGIHTGSVLSGVVGTKMPRYCLFGHHVTLANKMESESEAGRINISPTTYELIRDDKGLKFIRRSKSSLPDGFKMDSISGTCYFLERLTTYPSDESPPWQKLESPRVLRKRSPPLTGNQSERICNSDSIKSPTLSSKAVPKPEVTANSGSFFHDDKNGNFIKKPTKEQFSSECFKETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQN7</accession>
    <name>A0A6P8HQN7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295109 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558699.1">
        <property type="nucleotide sequence ID" value="XM_031702839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQN7"/>
    <dbReference type="GeneID" id="116295109"/>
    <dbReference type="KEGG" id="aten:116295109"/>
    <dbReference type="InParanoid" id="A0A6P8HQN7"/>
    <dbReference type="OrthoDB" id="70850at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38585">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38585:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558699.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31396" checksum="57A5F428D9B7376B" modified="2020-12-02" version="1">MADEFLRKVLESLRAKSKEILNGFRLKRKENGRPVRACDIVEATVLGIAAFPLSIGYFQTAIFRPLRITNNKRLIGPVFGLFSVAVSGSIASLLFVLYVNFSKDISTRAFETYKQKLDSLISPLQYSYSHYDLLLYSLGSLMVFKAFGGRFRSVLPSSLVHPGAFARVSLPAPGQLYASDAIREKLTKLGRKYGCHTCGTKRSPLFIGDHIPPNKLVKPGQKQRFFPQCTNCSKDQGISLSVNSKKLPIKTHGTTLRLYHLWLPLPAYLMWLRSDTDSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQX8</accession>
    <name>A0A6P8HQX8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gliomedin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555085.1">
        <property type="nucleotide sequence ID" value="XM_031699225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQX8"/>
    <dbReference type="GeneID" id="116291992"/>
    <dbReference type="KEGG" id="aten:116291992"/>
    <dbReference type="InParanoid" id="A0A6P8HQX8"/>
    <dbReference type="OrthoDB" id="6161718at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028012050" evidence="2">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555085.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14305" checksum="5057D88A78ED200A" modified="2020-12-02" version="1">MSQVPQASCKAVLLVLAVLLVAGRAAETSEIQDEGQMEKRVRGQNQTDMMTLLKTLQARLEQLEAKRIVCLRGRDGRDGVPGLPGAHGVRGRPGRNGQLGPRGPRGYRGPGGVVYVRWGRTTCPWGATLVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR43</accession>
    <name>A0A6P8HR43_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 23 member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116292052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555152.1">
        <property type="nucleotide sequence ID" value="XM_031699292.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HR43">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="GeneID" id="116292052"/>
    <dbReference type="KEGG" id="aten:116292052"/>
    <dbReference type="InParanoid" id="A0A6P8HR43"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031555152.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="67312" checksum="5FB82AF9270B8706" modified="2020-12-02" version="1">MQVLSPVASDAQNPSTSVSLTKVSVLKDDGQTRKQLSEKEKAKMRRKELGLAYAVDENPPWYVCITLGFQHYMTMVGGTLSQPFIISGAMCFANNPLVIAEVLSTLFFVSGIATLLQATFGVRLPIIQGGTFSFFAPMFAILSLPKWKCPVATSEGTNSTLNGTTIDSEEIWQLRMREIQGAIMASSVFQIVIGFSGVIGFMMRYIGPITVAPTVTLIGIALFHXAAEHAGNHWGISMMTVALIILFSQILCNVLVPLPSYQKNIGFCIKRQPIFKLFPIILAIVVSWCFCAIITAAGGFXSDPNHPNYKARTDARTIVLREAKWFRLPYPGQWGTPTVSAAGVFGMLAGVLASIIESVGDYYACARLSGAPPPPKHAINRGIGMEGVGCLLTGVFGTGTGTTSYSENIGAVGITKVGSLRVIQYGGLVMLVVGAVGKIGALFTTIPDPIVGGLFLAMFGMIACVGISNLQYVDMNSSRNIFIVGLALIMGLALSHYMNGHPGAINTGVDEIDQIVTVLFKTSMAVGGIIALILDNLIPGTQEERGLLVWCKQEESHDEKEEVVVSSMASIHVYDLPFGLNRLSKYNIAKFLPFLPYYPPPPEQKKNNFSLGERNGALTQEELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV16</accession>
    <name>A0A6P8HV16_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Adhesion G protein-coupled receptor E1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC116296389</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560259.1">
        <property type="nucleotide sequence ID" value="XM_031704399.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HV16">
        <property type="interactions" value="844"/>
    </dbReference>
    <dbReference type="GeneID" id="116296389"/>
    <dbReference type="KEGG" id="aten:116296389"/>
    <dbReference type="InParanoid" id="A0A6P8HV16"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Adhesion G protein-coupled receptor F5"/>
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        <property type="entry name" value="Fibrillin 2"/>
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        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Pro-epidermal growth factor"/>
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    </dbReference>
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        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="GAIN_dom_sf"/>
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    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
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    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
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    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
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    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
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    <dbReference type="PANTHER" id="PTHR24050:SF27">
        <property type="entry name" value="FIBRILLIN-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="6"/>
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    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
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        <property type="match status" value="13"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 21" id="KW-0732">Signal</keyword>
    <keyword evidence="11 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028021633" evidence="21">
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            <begin position="29"/>
            <end position="1423"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="1230"/>
            <end position="1257"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="1278"/>
            <end position="1301"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1307"/>
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        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
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    <feature type="domain" description="EGF-like" evidence="22">
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    <feature type="domain" description="EGF-like" evidence="22">
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            <begin position="1083"/>
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        </location>
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        </location>
    </feature>
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    <evidence type="ECO:0000259" key="22">
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    </evidence>
    <sequence length="1423" mass="156731" checksum="D05E0AC83816B9B9" modified="2020-12-02" version="1">MRFLCLKLAVKLFCFFCLIKIEVASLQGKDPNNQAALSGCVIFNFESPLQGWLLSGQAFNNQPVFGGNSTAPGHYGNWLIDTNSNATSPCQKSRTVIGGSLKGLMTSPPFQIRASNLTFLIGGGCNASKVRVELLVDNKTLFEETGNCKDSLVRKYWDVKGHQGKVAQIRIVDDSLDDVWGYIAFDDLRFAAECEELQSCSVKQSLCLEGKEMSKGFVCRCQSNQLESLPCENDNCTITNGNCQTFCTTNDCKCQQCTCSSGYTFNASKLACDDINECARNSGGCKHACVNTPGSYRCTCPSGYRLDNDNKGCVDINECDSPNQGGCKNAECANTEGSFNCICKDGYKKESSDPLRCNDIDECAEYQPCDSSQQCVNVPGSFRCDCPAGLHWSSTKCVDTNECATSNGGCEQECVNMEASYHCSCRAGYKLNPDGKTCQDKNDCETNNGGCQQTCRKINGSLECDCEIGYHLSNDNVTCLDVNECEIDSKCTHICNNTVGGYSCSCHHGYQLQPDNVTCLDIDECLLDKGNCSQLCVNTNGSYSCSCYQGYRLSNDGLTCEGVKECQISNDCEQICTNTNGSHKCSCLPGYELEKDNKKCRDIDECSTNPKELCEYACVNSPGSYECACPAGLFLNPDNRTCSSDIDECKSNNKCQHKCTNLTGSYSCSCFEGFALKPDNHSCEDINECLQDNICGYKCSNTRGGYQCLCPKGFKLTDDRRTCADIDECQVEGTCEENCTNLVGSYQCFCSKGKALQSDGKSCEVPAVLDKALDTAKNEIKDASSTTDLVEITKALSDSLTETKKISSKELKDTVQVLDQLQSKVIKENINSSVVYAKLLLTNYMKIVSNVLQPDNKESWQNISGKSSGVASLPAKVEKMSKAIFKLVQNKNMTALNVTVNNENIDLQFEVAKRKDFQGLAYSGKTTRVELGKSLVHDDSRNNQDDFVGVTIVVYKNLDVHMAANGVPAQMVTDGEPVVNSDVISVKVINVNQEYLATLQDPVTLHFSHKKWSNAQPYCNFINDTAASLISNDNMLWASEGCWVNSSHGNVTVCQCNHTTSYGLLMDVHQVYDNLHNTHKEALRYISLIGCSISIIFCFLTVLALTLAMRRPLEKKARFETFKLHINLVIAIGFAQIWFVVGSFLVDVELVACRVVSVFTHYFLTASFCWMLAEGINVYNKIVKVFSTKKYGKFYFTLGWGVPLVLVIVTSAAVFNKYGPQNICWLQEEVIWVFAVPVLVIIVANFFVLLSVVYVLLRKTMAFTSLPNKAKESPKVKRTFKVTVVLLPLLGLTWVFGFLAIDENFIVFHYLFAIINSLQGFFIFVAHCWINDSIRAALLEKLPSFPDKYKGGTTSAEGSQKGTTVDSATFDTLTQSVPMPVHITMSTVQLLNLGKNADCKTSSEAVNDCMDMEEDNQLPGLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVA9</accession>
    <name>A0A6P8HVA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemicentin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559258.1">
        <property type="nucleotide sequence ID" value="XM_031703398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVA9"/>
    <dbReference type="GeneID" id="116295552"/>
    <dbReference type="KEGG" id="aten:116295552"/>
    <dbReference type="InParanoid" id="A0A6P8HVA9"/>
    <dbReference type="OrthoDB" id="5988349at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF32">
        <property type="entry name" value="MAM DOMAIN CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="109"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="196"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="279"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559258.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44844" checksum="CC9644E04B5F04B0" modified="2020-12-02" version="1">MGFIFVFFALLVSAEVLVQLPQASSILISENRKNLIENQRASAFCNTSGFPNANVTWFKDSQPNVVVSSNPTLIFKSILRSNGGRYICNASNGSVSLNDSIFFNVMYPPEIVMISDNRIALENSSVTLRCIATGNPIPKIRFSKEGKSVPPTKQTKVIIELPRIQRTDSGTYRCSASNGIGNSIEKAFTLDVQYPPNIFYMPPKVKDSWLHDNVTLVCDASGNPTPTYTWRPPRADPIHSNVISFVVTNESQFGVYYCVVQNIRGGDSYSLTLNRTRFPPDPPIIANNVTTVTSRNFTLKWTRPNEHNSNITRYLVMRTRFFNNGSMDKMEYFSHDTLLHLNMSFFLDWGTSYRFAVSAENRQGDSGAGPPTNITVIAGRNIDRADYIPWEGWEIPSLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVL2</accession>
    <name>A0A6P8HVL2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Krueppel-like factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116293403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556685.1">
        <property type="nucleotide sequence ID" value="XM_031700825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVL2"/>
    <dbReference type="FunCoup" id="A0A6P8HVL2">
        <property type="interactions" value="1367"/>
    </dbReference>
    <dbReference type="GeneID" id="116293403"/>
    <dbReference type="KEGG" id="aten:116293403"/>
    <dbReference type="InParanoid" id="A0A6P8HVL2"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21973">
        <property type="entry name" value="KLF6_7_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF166">
        <property type="entry name" value="DENDRITIC ARBOR REDUCTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556685.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31978" checksum="D2171E61778D27CD" modified="2020-12-02" version="1">MDLQSPIPSSTIFLELQTVHDTGYFYSLPSLEDDWAQTRLEMDRYLCPEPSTVENKESNLGTPTPWNEFLLPFDEATFPFGDDWDIKPIDFNSSPTMPSVPTVLPETPTEPKPCVQLTVKPLKIKLPINVSEDLSKVSKPVLPLTPPSSPESSVPTIVVSNNQQRAPRPVSRVPRTKGSNAVNRASSPKDGAESKRRVHRCNFSGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCNWRFARSDELTRHYRKHTGAKPFKCVHCDRCFSRSDHLALHMKRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVP5</accession>
    <name>A0A6P8HVP5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock factor 2-binding protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556715.1">
        <property type="nucleotide sequence ID" value="XM_031700855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVP5"/>
    <dbReference type="FunCoup" id="A0A6P8HVP5">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="GeneID" id="116293434"/>
    <dbReference type="KEGG" id="aten:116293434"/>
    <dbReference type="InParanoid" id="A0A6P8HVP5"/>
    <dbReference type="OrthoDB" id="10065854at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039584">
        <property type="entry name" value="HSF2BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15434">
        <property type="entry name" value="HEAT SHOCK FACTOR 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15434:SF2">
        <property type="entry name" value="HEAT SHOCK FACTOR 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556715.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40137" checksum="606E7F6EA18C0B1C" modified="2020-12-02" version="1">MAANVENVLREKCKVYVQVGKDDFKRLTSEVKDIKEVIPKILTSDLLDSYSKLEASQEELQQVHSENHKLRTELDYLQQEHQRQIGEAEKRYNNLIGDYDRGREEKFDLKCQLADVNQQLIDQSDYCASLGASVCTLLWRVSRQQQSVSTLLEGAKAEEFLHLTRKTIISYFATWGEDDPQEKSEELEFVLALCGIITNIAAAPCGREFFTRKEIGQVLVDCLVTTLEKTSVQHNVKIRSLMLMALYNISINFRGLQYLISKPSLLPLMLRLIQEESDSEIKLNAARLLQSIVMEPECLSHEHLQQVKKLRYTFYLQTQSSKELFASCRLAESSWSTTHARLLMNTSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWS6</accession>
    <name>A0A6P8HWS6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116296008</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559833.1">
        <property type="nucleotide sequence ID" value="XM_031703973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWS6"/>
    <dbReference type="FunCoup" id="A0A6P8HWS6">
        <property type="interactions" value="2608"/>
    </dbReference>
    <dbReference type="GeneID" id="116296008"/>
    <dbReference type="KEGG" id="aten:116296008"/>
    <dbReference type="InParanoid" id="A0A6P8HWS6"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16226">
        <property type="entry name" value="EFh_CREC_Calumenin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000090">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028470033" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031559833.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="39858" checksum="428059AB83AB0B5D" modified="2020-12-02" version="1">MARISVGILVCALFVFAAARPQQEKKGKNRVFEGKVSDEDHFKEEEHNSEYDHEAFLGEEKKTFDQLTTEESKERLGKLVDKIDANGDGKVNHEELVQWIKRAAKRYVYEDVDRQWSHLKKIEEAKIPTDELVKGTKIDLEKPFTWDEYKNNTYGFIKDEDKEEYNYKDLIRRDKRRWEKADINHDDQLTKEEYTAFLHPEEYEYMKDVVVEETMEDIDKDKDGYISLEEYLGDLYPDSEKKEDTEEPDWVRTERKQFDEVRDKNKDGRMDKDEVRDWIIPPDFDHVSAEATHLINEADDDKDGLLSKSEIIDHHDVFVGSQATDFGEALTKNHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXX8</accession>
    <name>A0A6P8HXX8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 248-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116294066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557457.1">
        <property type="nucleotide sequence ID" value="XM_031701597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXX8"/>
    <dbReference type="FunCoup" id="A0A6P8HXX8">
        <property type="interactions" value="1035"/>
    </dbReference>
    <dbReference type="GeneID" id="116294066"/>
    <dbReference type="KEGG" id="aten:116294066"/>
    <dbReference type="InParanoid" id="A0A6P8HXX8"/>
    <dbReference type="OrthoDB" id="6329605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039493">
        <property type="entry name" value="TMEM248/TMEM219"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039587">
        <property type="entry name" value="TMEM248/TMEM219_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002:SF4">
        <property type="entry name" value="TMEM248_TMEM219 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 248-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14940">
        <property type="entry name" value="TMEM219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM248/TMEM219" evidence="6">
        <location>
            <begin position="10"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557457.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31389" checksum="78E13F3AD471BBF5" modified="2020-12-02" version="1">MLECKCIKNLVGFAASRPPFVIFTLCLAIFAAGLFSIGYYVQSYGYEGAEMSQWKTLIKHVSDKEFCMYGNNMSTQVNTTNTTIQSTPSSLNLVQVNLPVVLRFSPNSLFFGSVQNISHVTTVVQGSELGLRGEMASQLVNFTFSLEKPWSQSCGNQKCQGSVFSTCVSALLPEGMIPKDIPHYYCNATRLQNMALMVTSNHCGKYCCIDGITAKALFLRYFQSQPNLEGPSEMGLNDWDTVNLRLQYSSYFLFVMAITCILYGMIRGRSVKSVSKKANGQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYD8</accession>
    <name>A0A6P8HYD8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116296517</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116296517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560403.1">
        <property type="nucleotide sequence ID" value="XM_031704543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYD8"/>
    <dbReference type="GeneID" id="116296517"/>
    <dbReference type="KEGG" id="aten:116296517"/>
    <dbReference type="InParanoid" id="A0A6P8HYD8"/>
    <dbReference type="OrthoDB" id="2890956at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.176.10">
        <property type="entry name" value="Toxin ADP-ribosyltransferase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031560403.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43865" checksum="EC7A0F63524D1E96" modified="2020-12-02" version="1">MEILAHERTERYIQNENEFSKSANFNQIKPFFDGDSLSERMNKIREGIIYIREYWNHYDEFTNAVQNYITQNVEDTEAKVMMEEVLKSKKDWAKSREDVDSGFKAIRLYTSVKGYNEIFSLVNRVFRDDASTTQQELIIIAVFVIELINIDLFNYCLSHDRFNNFTGVVYRGMALKESDYGAFKALRNKEISGRYIAIPLCLMSTSTSLKIANSFIKRIMRGRVDHKPLLMKIHVIELEKEYLEHYRRRFPTSVVSTICAVDIKDLSLMSHEKEVILRGPFFQVLDFYDGEVIENQTCKVLEMVMLNTNRDHISTMQLGQDSALARQLFGNMVAATRCKFAIKYYEDKGLHRDVEEYKKLLTEKLDKLKELMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYS8</accession>
    <name>A0A6P8HYS8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294326</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557772.1">
        <property type="nucleotide sequence ID" value="XM_031701912.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294326"/>
    <dbReference type="KEGG" id="aten:116294326"/>
    <dbReference type="InParanoid" id="A0A6P8HYS8"/>
    <dbReference type="OrthoDB" id="5982703at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33845:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557772.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50110" checksum="E345F7B320EBE578" modified="2020-12-02" version="1">MKFLPQKYRESQTNWFGKRGISWHISVVYRRVEGVLQWQGFIHVVQSCSQDSLAVVSIVQHVLKTVKQEHNEIKKAFLRQDNAGCYHAAYNLLSCPEITASTGIKIVRVDFSDPQGGKGAADRLAATCKSHVRIHINEGNDVTTATQLKDALLSNGGIQDVRAVAIETISPTKIEYXQKIPGISKLNIFEFSSNSITTWRAYDIGKGKDIRLEEQSTESFCDDTYNKRAADECLRAARGYHTQSDVYSCPKDGCVRVFQRFSALEKHLSLERCSKSLEKQSLFDLAKVKYKAHLEEGVGVLPSLKFSSSNMRTSDLPAEEGWALKENKKSDHFSEKQRTYLVNKFNIGQTSGRKLNPEFVAKDMRRARGPDGLRLFNVSEFLKPQQILSYFSRLAAKVRQTVPDDLAIDPNAIEEEKNFSSARETVMSTLQLQHPITYDQYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYT6</accession>
    <name>A0A6P8HYT6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C20orf85 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557777.1">
        <property type="nucleotide sequence ID" value="XM_031701917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYT6"/>
    <dbReference type="FunCoup" id="A0A6P8HYT6">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="116294332"/>
    <dbReference type="KEGG" id="aten:116294332"/>
    <dbReference type="InParanoid" id="A0A6P8HYT6"/>
    <dbReference type="OrthoDB" id="10031946at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020339">
        <property type="entry name" value="C20orf85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31909">
        <property type="entry name" value="CHROMOSOME 20 ORF85 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31909:SF3">
        <property type="entry name" value="SIMILAR TO PROTEIN C20ORF85 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14945">
        <property type="entry name" value="LLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557777.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15270" checksum="9A265B60A45A0161" modified="2020-12-02" version="1">MYGRGSTKICNFVHVDEIWKDHVKLELTAQRKWPEKWGFLSKTYQQLEDDLLTIGEDTTEQNLKEASKPKDKDVSIPTPQEDKKPPVPFPKTDSQMIGWRLHYQTPKSMKYMSSCGKKDIIKQLGWPREGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYU3</accession>
    <name>A0A6P8HYU3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rap guanine nucleotide exchange factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116296654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560568.1">
        <property type="nucleotide sequence ID" value="XM_031704708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYU3"/>
    <dbReference type="FunCoup" id="A0A6P8HYU3">
        <property type="interactions" value="1764"/>
    </dbReference>
    <dbReference type="GeneID" id="116296654"/>
    <dbReference type="KEGG" id="aten:116296654"/>
    <dbReference type="InParanoid" id="A0A6P8HYU3"/>
    <dbReference type="OrthoDB" id="25179at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF224">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="545"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="692"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031560568.1"/>
        </source>
    </evidence>
    <sequence length="918" mass="104298" checksum="ACE50ACFBE11E523" modified="2020-12-02" version="1">MMASSFSKIMGFTKEFQSPQGHFTLPRGKKPKILKILRRASFSNKKKNSTQSPSFDYENQQDTLRRPNSRKSQQARDLEELERLQKELNSAALYFCLVLERKNMDIIMAKIPDNAAIVLDSVISIDDLLTTCIKLQKVNKDLVPYRKAVHKCMADLARWTDQLLVRGNVKGDLREGIEYMNALEKSVMEVVEITIPRLRKSEVQEEIRNSIFLFEGSTESILVGGENGDEMQVWNKRDSGISEGSGTCDMRDPPRSPVPRAVRDSGRGSYNCIIDTNNGHMAQDGSFHSSDKFLSPRRAQRNTLSSRTSKDSELSSFSGDSTVFKSPMVSPSGSQEFGRTPFHSARSSLEGSFYSVDELDNHNDHEVIPATLIGVEDNSHEPPPLQKKKKSFQVYIELLGSYNKPSEDILRRPTSAFDGYEETFRKSISHSASSTAIHSLSHRGNHHASGQYNQNGTEDNRAFSTPHLPSPSPTRETQIDWNQNSRSQEIPKKKLLSLVEEGASRKASNTSASSSSISSTDEDESTPALDCLDVSRFLVYRDDGQGNMLVGGAIDALIVYAAGASKSDLIFYEAFLTTYRTFISPKDLINKLLYRERRFRERGHKKASQNAFFLLLRVIDELNGKVERSILEQLMKEVYRLLCNGDLYIGKILRSKMLPKCDNYYNRLRSSSNPSTPQPSSGNSSCTILDFHAQDLAQQLTLIDAANFGAIEIPEILAWGKEQSETNSPNLAIFTDNFNKVSYWSRSYILSFEKQQDREKVYAKFLKIMKHLRRFNNFNSFLAVLSAMDCSAVRRLDWPRHYLDQLAEYTDLIDSSSSFRAYRTALAEATPPCIPYLGLILQDVTFVCLGNVDELPDGKVNFVKRWQLFNILDTFRRFKLMQYEFEVKDEIRQFFGGFNNFLNEDDLFERSLKLKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ08</accession>
    <name>A0A6P8HZ08_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Thimet oligopeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116297513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561619.1">
        <property type="nucleotide sequence ID" value="XM_031705759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ08"/>
    <dbReference type="FunCoup" id="A0A6P8HZ08">
        <property type="interactions" value="1944"/>
    </dbReference>
    <dbReference type="GeneID" id="116297513"/>
    <dbReference type="KEGG" id="aten:116297513"/>
    <dbReference type="InParanoid" id="A0A6P8HZ08"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="214"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031561619.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="76180" checksum="5DEEB467876389CD" modified="2020-12-02" version="1">MAEYFVEDVAFQWNLTPEDIAKRTDEVIERSRKVYDSVGALKPGEVTLESCLQALANNEREYSNSKAELEFLQHVSTDKEVRKASTEADRKISEFDVEMSMRKDIFDNLVALQEKNQAPMSSETKRLLERLIKLGKRNGLHLPSDVQDEIKAIKKKQSEISINFNSNLNEENTKLSFGLEELTGLPEDFINSLEKDEQGKFILTLKYPHYIPCMRKASNPETRRKMEYAFNRRCIEENTKILEELVELRQKMADLLGYPTHASYILEMRMAKTSKAVADFLSELATRLEPLAQDELKALLKLKEEECESLGYKFDGKINYWDMKYYMTLVEEKNYAVEHDKLKEYFPMDVVTKGLLDIYQDLLGLNFEEVEKPHVWHEDVQLFSVKEKATSNIIGYFYLDLFPREGKFSHAACFGLKPGCLRSDGKRQLSIAAMEANFTRPTEDKPSLLTHNEVETFFHEFGHVMHQICAKSEYALFSGTNVERDFVEAPSQMLENWCWEPEPLRRMSAHYKDGSAIPDDMLAKLIASRNANAGLFNLRQILLGTFDQTIHTSPKVNTADVYAELSSKILHIAATPGTNMSASFGHLAGGYDAQYYGYLWSEVFCMDMFYSRFKKEGIMNPKVGVDYKTCILQPGGSIDASDMLKNFLGRDPNQDAFLISKGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0M8</accession>
    <name>A0A6P8I0M8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PX domain-containing protein kinase-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Modulator of Na,K-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116297230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561283.1">
        <property type="nucleotide sequence ID" value="XM_031705423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0M8"/>
    <dbReference type="FunCoup" id="A0A6P8I0M8">
        <property type="interactions" value="1757"/>
    </dbReference>
    <dbReference type="GeneID" id="116297230"/>
    <dbReference type="KEGG" id="aten:116297230"/>
    <dbReference type="InParanoid" id="A0A6P8I0M8"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043271">
        <property type="term" value="P:negative regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22062">
        <property type="entry name" value="WH2_DdVASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000010">
        <property type="entry name" value="PX domain-containing protein kinase-like protein isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000830">
        <property type="entry name" value="PX domain-containing serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF40">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="84"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031561283.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60443" checksum="ABF1ACA5FECFAA02" modified="2020-12-02" version="1">MAWRNRGRAVLDDTIPLMCVFEGIDKKEHVDYFIKVQRGAKPEDSWQVVHRYSDFAALHSILESSGIELPLPPKKVFGNMDSTFIAERQQGLQSYLHFILANPLLSRHISVKKFLDPVKYSENFQEQAMQHVAMFLRSVPNWEIVEPLPDIGWRLRKSYFLIKPTDPSKKDVRHILTWQHPHIYPTGFATFTEHGVIVVRNFLPDGTLRDYLCKAKPKLNQLKKYGNPKARNTLAIPQVQIYGKQILETLKFLHDKGYPYGHLHTGNIVLEGNICKLLDIENGLLGIPSIHRNRYVPYKKIQDKESEDVYCFAHVLYEMTFGEPLKMSTISQLPPTCPNDLRTILESILKDEPLTKKGLPSVTELLESPFFSSVNLPPSEKPIFKIPSKIKESIRMAKEKAEQRLKEDQKFLRQFRRVSKAHAHHMSEEEKKKRKKSAKKSQKSDSARPVSPTGPPPSSPTPVSRTQAPAAPTPSAPPPPQAPTAPPPPATQQPARSTPPPSSQGRGALLSSISSFKKGGLKKAVTVDKSKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0X8</accession>
    <name>A0A6P8I0X8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116297160</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561189.1">
        <property type="nucleotide sequence ID" value="XM_031705329.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561191.1">
        <property type="nucleotide sequence ID" value="XM_031705331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0X8"/>
    <dbReference type="GeneID" id="116297160"/>
    <dbReference type="KEGG" id="aten:116297160"/>
    <dbReference type="OrthoDB" id="9973968at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF335">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653112" evidence="3">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="6">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="151"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031561189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561191.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34838" checksum="E3F331A93905FCA7" modified="2020-12-02" version="1">MQYVVFGILLTSLLTGQIILDPVISHRLHHGCQNVSSVANYKLEGHVFDTIYGKNFETCVISCEDDKRCLSLNYKHVTRACELNTRSKSTNPCDLVPRDGVVYMDSLKHYTKDACALFPCKNGVTCLVTSCCRGFKCDCGVFYTGEFCEDCTLLGEPLGMKSKAIPDAALQASSYRPGYPPSNGRLDDDKGWISSSNDVMSPYFQVNLKETKSISRVCLQGTNISSFPNGGAWIKQLYFSFSLDGSNWTDYITQDGHKHLQGCTTVEGKKFFNFTNPMQAKYVQIRPVTWEQFPALRMELYGCEANLKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I181</accession>
    <name>A0A6P8I181_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM149A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM149 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562339.1">
        <property type="nucleotide sequence ID" value="XM_031706479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I181"/>
    <dbReference type="GeneID" id="116298110"/>
    <dbReference type="KEGG" id="aten:116298110"/>
    <dbReference type="InParanoid" id="A0A6P8I181"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022194">
        <property type="entry name" value="DUF3719"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039630">
        <property type="entry name" value="FAM149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997:SF1">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12516">
        <property type="entry name" value="DUF3719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3719" evidence="2">
        <location>
            <begin position="140"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562339.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39432" checksum="86B059BCC7C71C61" modified="2020-12-02" version="1">MTLLGDWMYTSCSRIKKRVKKPEVEKVSFILRGRGFSSRGGFESLYPLPEKPEETLPLSYLETVQEAINSYRTSDGSGCSSPTTDNTNSLNNSLWASNTWSTNTGNLTGRSSVYSWGNDDEFDRQASATVQRMFDEISQMLFEGKFFDGSPQLLSECREWCTKFPHLRICGDQCAVPQDQGTKYIPLPPDDPRVYNYRPQTSVLEDMEEVNTLDSQGLTVQGTKIKPARVDVSEYQDLSDSDEENPLAELEEEIFEEEGEFEEYLAYDFPALDEELMVLRSRHNRHKRHFRLGFPPVTPNACARDTLFSQMFDLLWGEVGFTSPFFFRKETLSSYLSLLLYLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1S3</accession>
    <name>A0A6P8I1S3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116298230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR5/wds family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562474.1">
        <property type="nucleotide sequence ID" value="XM_031706614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1S3"/>
    <dbReference type="FunCoup" id="A0A6P8I1S3">
        <property type="interactions" value="1969"/>
    </dbReference>
    <dbReference type="GeneID" id="116298230"/>
    <dbReference type="KEGG" id="aten:116298230"/>
    <dbReference type="InParanoid" id="A0A6P8I1S3"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000029">
        <property type="entry name" value="WD repeat-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="6">
        <location>
            <begin position="56"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562474.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38303" checksum="DC582BDA656F56E1" modified="2020-12-02" version="1">MASPGNTVKSEPQSASNSSINEKSKALTSHQPMNTTSTVPASAASVKKPNYQLKYTLSGHNKAISSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLVSASDDKTLKIWDFSTGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVTAVHFNRDGALIVSSSYDGLCRIWDTTSGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFGNFSVTGGKWIVSGSEDNMVYIWNLQSKEVAQKLEGHIDVVLCCACHPTENIIASGALENDKTIKIWKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1Z4</accession>
    <name>A0A6P8I1Z4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HMG box-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">HMG box transcription factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">High mobility group box transcription factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 25 26 27 28" type="primary">LOC116295274</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25 26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24 25 26">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558907.1">
        <property type="nucleotide sequence ID" value="XM_031703047.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558908.1">
        <property type="nucleotide sequence ID" value="XM_031703048.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558909.1">
        <property type="nucleotide sequence ID" value="XM_031703049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558910.1">
        <property type="nucleotide sequence ID" value="XM_031703050.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558911.1">
        <property type="nucleotide sequence ID" value="XM_031703051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1Z4"/>
    <dbReference type="GeneID" id="116295274"/>
    <dbReference type="KEGG" id="aten:116295274"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21988">
        <property type="entry name" value="HMG-box_HBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003652">
        <property type="entry name" value="Ataxin_AXH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036096">
        <property type="entry name" value="Ataxin_AXH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039655">
        <property type="entry name" value="HBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15499">
        <property type="entry name" value="HMG BOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15499:SF3">
        <property type="entry name" value="HMG BOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08517">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00536">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102031">
        <property type="entry name" value="AXH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51148">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AXH" evidence="22">
        <location>
            <begin position="133"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="20">
        <location>
            <begin position="325"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="18">
        <location>
            <begin position="325"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031558907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031558908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_031558909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_031558910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_031558911.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="47182" checksum="F4190C0489638E71" modified="2020-12-02" version="1">MQPVQDRLVKPFACTYCQKSFKSSNGLKYHLEKIHSEDDLMDMRKLCSHDPGTNKAKSVPPALDLTKNEDSFSQGILAEFAFIATGPQSPLVQEVSGYDNESPCDPMDIDYNIPSVESDISTTSPPLDPQWYRYATPPPTAWSCFLEGTRIQTEGQKEWKYAEDLGNEDIPHVCHPSDGLRLMSYERLVQVVDDEKEYVASFHSTSADQPSLRAEVSGDHPFFVKYKGWCSFNPDRTLTKYGILCQNLTPNDVCLPSSHPDVMKAIRIGRSSNMFDFTYSDSNAVLTLSSMIKDCQEHRSRRTKLGLFSAKSRVPKTPSQIQQLNKRPMNAFMLFAKRFRVEITQAHPGKDNRAISVILGDKWKSMDEDDREQYVQEAKQLAEEHKKFNPDCWKRKRSGTQGRTKSSSLKRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I287</accession>
    <name>A0A6P8I287_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297541</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561646.1">
        <property type="nucleotide sequence ID" value="XM_031705786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I287"/>
    <dbReference type="GeneID" id="116297541"/>
    <dbReference type="KEGG" id="aten:116297541"/>
    <dbReference type="InParanoid" id="A0A6P8I287"/>
    <dbReference type="OrthoDB" id="5976238at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027783666" evidence="1">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561646.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32355" checksum="30CC51C05CBEDD65" modified="2020-12-02" version="1">MYLGTLLLGAATTWMLTSMCSAGICDEGPPGKFCFPDLSGYHDCVVNKTTGKIDDKLYNCPQNTRCKCMGIPCSTNTPCGPYRLPPIFADDFTADINDIKTVVTPAGKQTTYSHFGIWRDSKNQKYRLDATIAPHDPPYEYFILLPNNQSSFDVYEVIPSTTSCKKTTITKFPPKLQEPSYFQYNGTVIVTGIVCDHWIWLSGGRNSGRPIISQSWDTNQKKPIQYLAYSPGSQMSKTSVRIQRYFGLFDAGTPDPEKFVLPRYCEKELEKTPKPSDEFFESRDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2B2</accession>
    <name>A0A6P8I2B2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ARF GTPase-activating protein GIT2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116297786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561938.1">
        <property type="nucleotide sequence ID" value="XM_031706078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2B2"/>
    <dbReference type="FunCoup" id="A0A6P8I2B2">
        <property type="interactions" value="1954"/>
    </dbReference>
    <dbReference type="GeneID" id="116297786"/>
    <dbReference type="KEGG" id="aten:116297786"/>
    <dbReference type="InParanoid" id="A0A6P8I2B2"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08833">
        <property type="entry name" value="ArfGap_GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047161">
        <property type="entry name" value="GIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032352">
        <property type="entry name" value="GIT1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097:SF3">
        <property type="entry name" value="ARF GTPASE-ACTIVATING PROTEIN GIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46097">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16559">
        <property type="entry name" value="GIT_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="12">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="520"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="438"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031561938.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="82622" checksum="B1D46415742FCA30" modified="2020-12-02" version="1">MTSRPKLRALTDICADCSAPGPEWASLNRCVLICDECCSVHRSLGRHVSQVKHLRHSVWHPNLLTMVIQLVNNGANSIWEHNYTAPSIEHGQSRGGIRKPNPKDIVHPTKYNFIKAKYQALQFVHRLASKDDDAATIDYTLQLHSCVRTSNLETSLRLLSNGAQPNYIHPEKGNTPLHIATSAGQALQVELLVVHGADPTILDVNGKTPMDYAIEAGNRDLAQRLFEMQYELTDRLSFYLCGRKPDHPTGVRYLIPTMANSCLDLSQDAQKAKLKLKALSNHLFEELAADVYDEVDRRECDAIWLANQNHSALVNDTTTVPFLPVNPAFTSTRNQGRQKLALFNAQELATLILDILNDARRREQDSNPDLGPGSVMDSGMFPIEEDKRMSHDYDEVASDDELENTTQKEPMLRSTKGSTEKSTSTSFVLEDTIPTENYLELKCALASAEARIQQLLQVNASMNQGIQELQSVVQRLRIDKYNLQKQLGIEEEQMSDSVFSFENGPHEYMNAEMLRMNNMAAGDDEDDDDHVDIDEITPYASPGELLKNRAKQNQSALGTSQMYGEIKKKKVNPYDNVPDEEEPDRGEDEKAYKNGLSDQQIDEEAERVLSEAEGIVQAAAREFEPSQEDVVRCTEQITKKIQELLLAAQAGKHSCFIPCSNKINSAVNDMASLFPENPDADAVRVSLQLMANSASRLSVECKSAVLPGNTVDMAFLTQQVIQCAYDIAKAAKQLVTTFSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3Y7</accession>
    <name>A0A6P8I3Y7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295741</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559510.1">
        <property type="nucleotide sequence ID" value="XM_031703650.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116295741"/>
    <dbReference type="InParanoid" id="A0A6P8I3Y7"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028234762" evidence="1">
        <location>
            <begin position="24"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="322"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559510.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="81155" checksum="C1ECCD382844F07A" modified="2020-12-02" version="1">MNFAAAGLLSLTGVLVCLLPGSARELKATVSMSKIKGTVTFTQTSDPLAETTMKLDLDGLTELLNLRVHEIPMIYQGGASSSCNLNAVGQIFDPTSWNTTSACTNMNQQNCAVGDLTGKSVAFEAANSKSSFKYQNLPLSGKNSIYGRTLLFTTTSHVPKACAIITSTEQAFYAVAYFKGPVAGTVHFKEEGSMINTLVTVNLFYVSDATISQKYFLKLHVNRVGXRMTSDQCANAGAVLNPDLQTELGVFNVKEATSGRSSTQIAVNVANLAVNGANTVIGHSLLLYSVDNPSKPIACTNILKLLPKKAKAVFTREDTDGVTGTFEFSQTSPFDPTNVKININKLGNKAEGYHVHEYPNPSYKGITDNAQACSSANAGDHLNPYGVVASSSPASGTFDEYEIGDLSAKYGTFLNKNDHDGSYTDYNLPLFGNNSIVGRSIVIHKLKKDGNKRWVCRNIDLDLDDVVKMETRSHFTGPDILGDIVMTHYRSIDNNAAPFDTTFYLDLKHVNGKQSYDHNWHVHDNAVGDDMNKAMNDGRCESLGPHYNPFSVFVEGNYKTTCTSNNPLRCELGDTSAKTATYNLGSGPRFYTDVDTPLFGEHSVAGRGFVVHSAXKGAPRQGCADINPNTTLFKEKTLNILKPADPFSRADFITKMASVLKADKWRIFYVKYTADLKVSSSSKCSRISFGIFGDDQANTAFDTTVRNNPEKLKPYMPDSRCNHSQGLHVHLLLLTTAVLVCIAAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3Z6</accession>
    <name>A0A6P8I3Z6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Exonuclease 1</fullName>
            <ecNumber evidence="16">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116298825</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_031563289.1">
        <property type="nucleotide sequence ID" value="XM_031707429.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I3Z6">
        <property type="interactions" value="1359"/>
    </dbReference>
    <dbReference type="GeneID" id="116298825"/>
    <dbReference type="KEGG" id="aten:116298825"/>
    <dbReference type="InParanoid" id="A0A6P8I3Z6"/>
    <dbReference type="OrthoDB" id="6020421at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 16" id="KW-0228">DNA excision</keyword>
    <keyword evidence="14 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 16" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="18">
        <location>
            <begin position="138"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="433"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="716"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031563289.1"/>
        </source>
    </evidence>
    <sequence length="809" mass="90585" checksum="7F8DF948055AD2BC" modified="2020-12-02" version="1">MGIQGLLPLLKPIHKKVSISEFSGQTVGIDTYCWLHKGAYGCAMDIVEGKKTKIYLNYVLKRLDMLLYHNVKPYLVLDGGNLPSKASKEAERRRSRQENKAKGLALLRAGNKSQACECFQKCVDITPEMALEVVKACRERNIDYVVAPYEADAQLAYLMKTGITQATISEDSDLLVYGCNKVIFKMDECGRGTLVDLADLPKLTDLRMHEFTLEKFKQMCILSGCDYLPSIKGVGLKTANKLMRKHSTIEKLVRSIRLENKLKVPVDYEKSFQQAYETFLYQLVFDPRSSSLIPLTPLPDGVLPGDLAFAGPMLSPEEALGIALGNINPITRKIMDDYDPDTXKTEQPPPSLPSDTPSACAFSFASKKDRQSLTPSSLESLHVAENNMTLEKESSLGHCRRFLLPPLKKTSKEKERVPDDKDLMNMYTFVKRKDSSSSLTRSQTVHNGCGMSRKPRLKNHFKTTTSDEYLVPRKPRLKNPFRTSIEESSDKESNATGQTSCYFDNEDVNNVTGQKDLNTDEHSTTDTDLSVRDEKTYDDLGDPAVSAKELDDAPSLPTWKYEESDMNILPEEEKENSPTPENSIASTLTCNTSSYDCVSQEREEGTEPMEDSSQPINDSQRSWKSDSSIDTTVTSKMKRISNINSNEKNPKLASTRKRTATLSSLHKFTYQPKKRTSEEPISRTNESVESLPLTQEVIDSGYLSDEEESTDADTPSENRKDEVNGLSMEKESITPLRSSSGSDMTSKRLIQLKNKTAAARRTTGLSRCKSLGISKRKTSTKPALPGNASSTLFHYFEFNKNKRVRLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4Q1</accession>
    <name>A0A6P8I4Q1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Probable voltage-dependent R-type calcium channel subunit alpha-1E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116298203</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562446.1">
        <property type="nucleotide sequence ID" value="XM_031706586.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4Q1">
        <property type="interactions" value="917"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116298203"/>
    <dbReference type="InParanoid" id="A0A6P8I4Q1"/>
    <dbReference type="OrthoDB" id="5982588at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000059">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
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        <property type="entry name" value="CACHANNEL"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 16" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="67"/>
            <end position="86"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="508"/>
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        <ligand>
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            <dbReference type="RuleBase" id="RU003808"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="1851" mass="214258" checksum="B38E26F6F2F6149A" modified="2020-12-02" version="1">MANEANDGLQTGDSKLRATATELLQRKCRPNVSEPVRTSYNSLFCLAETNPVRFYCKKIVESKRFEYFILITIAVNCIVLTLDSPLPEGDTTELNEQLEIAEKVFIVIYCIEAAAKIIALGFAFHPNAYLRNGWNILDFAVVVIGLIGLIWDNQIDNSLNNQKDTLKVLRAVRVLRPLKIVSGIPSLQVVMKTIWRAMVPLLQILVLILFVIVIYAIIGLELLKGTFHNTCYDKHGNIDRTFLLPXICDKESSGRQCPTNHTCQRHDEIWPGPNKGITNFDNIFLSMLTVFQCITMEGWTDVMYNTYDARDYDTRAVTSITYISLIMIGSFLMLNLVLGVLSGEFAKERERVEHRRKFFKLRRQQQMERDLSGYLEWIAKAEDIILXEEREQHGVGEGGPRDPLKKRYSLSDSIMHLIEDHGEIIQHLKNKKKTQEQSTLSWSERYSIIRKFNKKERIFRGRVRSMVRSPIFYWGVLLCVFLNTIIMSTEHYDQPYWLEQMQVISERVFLGLFVAEMLLKLYGLAPRNYFASAFNKFDFIVVQASIIELFLEKYFKINYGSSVFRSLRLLRVFKFTRVWSSLRNLVTSLLKSMRSILSLIFLLLLFIFIFALLGMQLFGGKFSTRLDAPRTNFDDFIKAMLAVFQIMTGEDWNTIMYDGIESAGGPKSVWGILASLYFVALVIIGDYTLLNVFLAIAVDNLANAQDLTRLDEEADRQREQMKKKRLEKRRNGWAKAKQLPMIMAITKINNHGSNNPFPNSKPVFGIQHNSPRNDRLSKMSAVRIKISEDSPSLSSKNGRISRQNTTDNEREDDTEDPEMLSRTPSPHRFSLSLRTEGKIMRRRNIHRSNIPIIRKNAMFIFGPDNPVRRFCHWMVNLRYFDTFILFIIVISSILLAFEDPVNPESYTNEVLGYFDYVITAIFALEVIAKMIDLGVIFHKGSYLRDWWNVIDAFVVACNIAALVFNRKTEDPSHSDNSSVQDAIKSFRVLRVLRPLKAINKSKNLKTVFQCMVFSLKNVRNILLITALFYFIFAVIGVQLFKGKFFYCTDSSKETEKDCKGYYFKYTVDTKISLNNFEVKPREWKRRNFNFDSVPRAMLTVFSLSTGEGWPTAMYHTIDATGIDQGPRRDYQMHVSIYYVCFVVVFSFFFLNIFVALIIVTFQEQGEKEMVGCELTRNQRDCIQFAMTARPRQRYMPQDKTTCFYKVWRVVDSKPFEIFIMSMIVLNAAVLMLSNYFRDYWNVFDFTIVVATLVGVVIDMAGADNKLGIDPSFFRLFRAARLVKLLRQGYTIRILLWTFFQSFKALPYVVILIAMLFFVYAVIGMQLFGRIAQLPNKEINTHNHFQSFLQSLLVLFRAATGENWHLIMLSCFDNAPCQRGTICGSTAASIFYFCTFYFFCSFLMLNLFVAVIMDNFEYLTRDESILGPHHLDEFVRVWSEYDPGATGRIKHTQVYFLMCDMSPPVGFGKKCPKFIAYKRLIKMNMPIMGDNTVLFTSTLFALIRTSLGIFSHGDPAYADSELRRTIKKIWPKTPKKTLDKMIPLQSVLSSQQMTIGKIYCAKLIYENYKHLKKKRLEQRKKKPRRPSLFRRMLGVLRSGTSNSEEDDDNELRPPPGLLTHRRRSKTMDSIPTFSKEKLETIQPKRRMYRSLKFFRKPFGRTDSNSEDDERKIRKSVRFKDAPMDLTDINPTIISTDNEDDEPKETTRRKRKPVKYSYKNPVAIEDARNETNSSTDSQSRSSSDVHSPPIVRIHRSSPLTLDPGNLEEHRTKIRNHLRLDPFPDVIKSAESSPRHSLAASSDFYARSRPEDPKEQRSKEIINQINEEISQAVRSGRSAYCIFGMFDDDEETWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5A1</accession>
    <name>A0A6P8I5A1_ACTTE</name>
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        <submittedName>
            <fullName evidence="11">CAP-Gly domain-containing linker protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116296118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559935.1">
        <property type="nucleotide sequence ID" value="XM_031704075.1"/>
    </dbReference>
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        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="GeneID" id="116296118"/>
    <dbReference type="KEGG" id="aten:116296118"/>
    <dbReference type="InParanoid" id="A0A6P8I5A1"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF82">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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            <begin position="1382"/>
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    </feature>
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            <begin position="404"/>
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        <location>
            <begin position="1294"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="65"/>
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    </feature>
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            <begin position="99"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="363"/>
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        </location>
    </feature>
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        <location>
            <begin position="936"/>
            <end position="951"/>
        </location>
    </feature>
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        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031559935.1"/>
        </source>
    </evidence>
    <sequence length="1427" mass="159918" checksum="4EA691C00EB58CA5" modified="2020-12-02" version="1">MSHIPQVKTGLKPPTKVHKPIQGGGGSATSPTGIVKPRGNPAXRPLSTPGAVKTTPSAGKSTTGSGVVRPRGSVNNVGGIASPRGSVHATSSQQLLPKLSRENSETRLSYRREGSSSSLRSTGSESSESVVRRRSSSSSSSQQGATPAADLKKFFKIGDRVLVSGTKTGVIGFIGETKFAKGDWAGIILDEPTGKNDGSVAGVRYFECQPLHGVFTKLEKITKINKVNVTHHNDDSTTALEIGDRVVVSGTKIGTVRYAGTTGFAKGEWAGVELDEPLGKNDGAVAGTRYFQCEQDFGLFAPIHKVIKTGKKESTKLPCSPPPTQKEQPLSIPPQLQESVLNSVNETPQGQAKTDKFVVSPESTSLSLSSSSTSTAGGQKREVESQDQPDVSPGKAPAHVSLQLLALQEALQEREMQIQALLEERDFERNEVASATSQVSKAEEELANIKKKHEQAAADNAKSIQELKNLVDLAEKEKADLYLQIEDEKRKNEDLQFKLEEEEITLGDELKTEEEQIKTLTQDLQEKQDEMKKLTEQLEQTKVEKSSTTMKLQEKEHKLLESNQQLSALKASFEXSQMKVQELEAKIFSVEEKHSAVSSEASQGMKEQLERIKKLEKELSLSNEREKQYQTRIENTKYELKIAMEENDSLKLQIEDLTAKLISKENEFDSMSDELKQIKSATLELQKQLQISEAKTMNLASDKTKLECEIAELMKNSGSNSERLTYLNDQLREKDRMLDELKGASAESQIQIARLTEXVAEAKECHSKDLEKLGKSQDEQTKKLINQINSLKTDLEKQKDENARLVQTHKQELEKLEQTKNEESGTLTSRLNHQKEQLQKITEDLNLTKNQLQVITQDRDNAKELNNAQQTEVNTYKTXLNENRTLLEKLTKELEETKLQLQNTTQDRDVIKERETKSQSVLTSLLAQLEEKNATQERLSSELNTMKSRQQQXEEERDNLKENXNTKQTEIKTLKSELDESRTLLDTMTKQLEEEKKQMKNTVQERDIMKEKCSQYETEIQAKQNEISQVTSKLDAAVSEKSLLTSAQGDTEKKISEVIEKYEKLNSDYQAVLQEKNDKTKMCEENEHQVKTLNQEKEAILQEKQNTLSKLDELQAQYSALKKEMDTLKTHSTQKEEELLLLKSSASDKVSESTELQSQLDQVKSERDQFKRKVVVLEEQSNLLQEQIKYLGNEKTAIESQKDEMVDALAKAQDEIISLNARVQERPASLASEIPSLGMENDLEVTKHELKLKEEQLAKYKQQVLDVKKQMAASMASNNAGGDSQDTADLAVKLVETEDLLEATIAEKENLDAQVEFLNSVIVDLQRKNEENEQRIELLXMGDTRPNGLLDSPELDEAPIPRSNIRLFCDICDVFDEHDTDDCPAQASEAPDVGSMHHGSRTEPRPYCTTCEVFGHWTEDCDDEVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I677</accession>
    <name>A0A6P8I677_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myophilin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563453.1">
        <property type="nucleotide sequence ID" value="XM_031707593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I677"/>
    <dbReference type="GeneID" id="116298992"/>
    <dbReference type="KEGG" id="aten:116298992"/>
    <dbReference type="InParanoid" id="A0A6P8I677"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563453.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15495" checksum="4CF2FFDDCF0B9E7B" modified="2020-12-02" version="1">MDEVEVEIPSMSNTKSKISGKWDDSLVSEICSWITKHTGESFKHGNQDEFAASLKDGVILCNLANAIQPGAIRKPNKPGKMAFKMMENIGWFVDFITAYGVQHEYIFVTVDLYEKQNVWQVVLALRALKDKAAEKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I692</accession>
    <name>A0A6P8I692_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116299007</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563473.1">
        <property type="nucleotide sequence ID" value="XM_031707613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I692"/>
    <dbReference type="GeneID" id="116299007"/>
    <dbReference type="KEGG" id="aten:116299007"/>
    <dbReference type="InParanoid" id="A0A6P8I692"/>
    <dbReference type="OrthoDB" id="5973323at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563473.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15707" checksum="6CFA6F23159DA10F" modified="2020-12-02" version="1">MAEKTRPKSRQNEEERTKEQQENVLELNIVYKGKDFRLSFSLDADKQTICKEIKRQTGVKGAFYLHYGDSSNNYLHSSSLTLANISKLSGSSLEVRGGDWINKGGDSIWYYFSQTLKPNVQERLTRQQWVPFDNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6W1</accession>
    <name>A0A6P8I6W1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">High-affinity lysophosphatidic acid receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116296568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560465.1">
        <property type="nucleotide sequence ID" value="XM_031704605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6W1"/>
    <dbReference type="GeneID" id="116296568"/>
    <dbReference type="KEGG" id="aten:116296568"/>
    <dbReference type="InParanoid" id="A0A6P8I6W1"/>
    <dbReference type="OrthoDB" id="5955240at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="68"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031560465.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="49654" checksum="04F26D349F8B157F" modified="2020-12-02" version="1">MAPCLLNTNAKQILSFGGNSSQPGRLINCSNTNFSFVNNETKDLDNLEEVNLGKSIMMLFAIGVAVMGNFFIIFTYCKNFKMRTITNTLVVNLCAADLLSSIFDLPFWLSLTLGSTLYKQFTLCRIIFCFEDLFHIVAILTMCGIAIDRYVTLVKGLRRLMTHRRAHLLIVWSWIQALISAAPWNLIHKLHGSKRCTTFPHFYEPSIRIEVFNIFLKVINIVFPFLLCYYVFYRIIQAVRGRSKVNIDNNYVSRNYSAERFAVDAYKRSSKTAIILFLMFFICTFPELCVTFWSVITSDKVGFGIGFITYFIFTLKRSLFPAIYIFRNRVIWSYIHETLTCAFCRGNGNSIHNDSLSYVPADQSISCFTVFGRNFYRSRIDPSVFDGEKNYFPKNLEVCFVCDGKEVIAVGDKFTDITKVEEKKVNPSSSSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7S7</accession>
    <name>A0A6P8I7S7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trace amine-associated receptor 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116297098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561117.1">
        <property type="nucleotide sequence ID" value="XM_031705257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7S7"/>
    <dbReference type="FunCoup" id="A0A6P8I7S7">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="GeneID" id="116297098"/>
    <dbReference type="KEGG" id="aten:116297098"/>
    <dbReference type="InParanoid" id="A0A6P8I7S7"/>
    <dbReference type="OrthoDB" id="5960104at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="34"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031561117.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35538" checksum="D1482B99A7DA0E72" modified="2020-12-02" version="1">MDICSYESAYFDHPVYRISISVVYSASSLIATTLNFLILVSIWKTPSLHNPSFMLIANLALSDFINGTIGEPFMVCTNYVALKKQKHVFCYIWKIARAVTYCTASVSLQTLALISIDRLLAVKLLNRYRSVVTLKRVAKLLIIWWIGSLCLANLIFLNVKIENLKHLLIMIEVFMFVLLSTVSFCYTMAFFSLRKITSSISPDSSSDPNTTRPNIDVSKYRKSLTTMIVVFTVIMISYLPYVCIALATAVSFDLAKPEDNQFLYQLFLGSELVMVSNSSLNPLIYLWRMGELREVVKTTVKKILRLEHSANNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I809</accession>
    <name>A0A6P8I809_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC116298950 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116298950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563396.1">
        <property type="nucleotide sequence ID" value="XM_031707536.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563397.1">
        <property type="nucleotide sequence ID" value="XM_031707537.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116298950"/>
    <dbReference type="OrthoDB" id="5989148at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32158:SF21">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32158">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653163" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="966"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563397.1"/>
        </source>
    </evidence>
    <sequence length="1268" mass="140879" checksum="3BDF373E70FFEB34" modified="2020-12-02" version="1">MAVGGKCTVVLLLFFYFISLESLSFAAGEPWNRTIYVSPKGNDSDTCGDEDFPCRTVDQGLQNAVTKGASSTRVLLERGQYNLNTSFNFTNIENFAIXGEGGAEEVIITCAENTSLAFTLVRDLXFQGFTLRKCGGWHASSVGKEDWKGNISNPKFISAVYINYCYGLQFLNVTIADTPGVGLNVYTVSGKVVILNSNFDRNVPNDSNQTVQNQNIDYYQEILAESSGRFAKAGGGVFLSVGEMKYNPLNPLEIPRKEAIIYTKPTDIIIQNCYFTNNIAPTPDIAIPEIPTLPFSRGGGLALFLFGNSTDNRVVIDSSVFANNTAVWGGGMQIDLQNRTANNTVKVTNTVFENNFARAEGGGFRLSSTVEQDFLILPNIFNFASCQITNNSALWGGGLATYGATSLAPLNTLVQFKQTEITFKXCNISRNSGTVGSAIGAFLVNRNEDDIGPGLPYDIIFEHCDISHNNVTTASKSYVVGQGAIYADEVPLVFKNNVIISYNNGTAVVLDSAIMEVHNNVVFENNKGFRGGAISLYGSARIILAKRSKLSFLHNFCEEKGGALYIEAPGPPLVSFNANGAQIHKCFLAYYKDGIDYNEWDTEIIFQNNSVGDKSFEINSSGRSVFASTLRDCLRVGETRDKNTALEWKFIKYRGGGGENVSFKGEVVTEPIDIIFNSSEWIVAPSQVFNATVELIDEKGNNVYGIVQVLIHSNPSVSLKGTSALFLVXNHIKGLAIRGKPGDKFKVELKTTGKHLVQKTLGNLTVQNCFPGFLFNKDDHDCVCASKDQSGIYNCSEDGKTLFIRDGYWAGVVNDKFLTYICPDTYCRANGLSNGQAQAYKYEPDKMCIESRKSDGILCGACKANYTVVLGSEECXSECSNLYLLTVIPYGIVLFLIVMLVTLINLDVFTGYLNAWLYSFQVMTLLFIEGFTLDSFMQFMIGLANIKIKLPRGSCFMEKMDDADKLVIMYILPVYIFIAVYILAKVVRKYPNWCYSRRVKAPFRALCTLFVLCYTNITTITLKLLYPAHIGGKTVLFMDGQVDFFKGKHIGYAVIAILFLIFIVIPCPLILMFTPFITKLLRPLVNVFTLKPYYDAFQGCFKDEYRWCSAFYFVCRLYLIIISTYMTPSPMKRAILEDSCMIILAVFVYLKPYKQEYNWLNLLDAVLLSNLGIMAIFSTALQNAQSFGLSYIGTIKLFIRMLSYVPLGYLLCXXIYQAFKYREALKAYMIMKMKSREDSVLIDGYSDAEPQSLVSDPENAHQLDNVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9E5</accession>
    <name>A0A6P8I9E5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P2X purinoceptor 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565199.1">
        <property type="nucleotide sequence ID" value="XM_031709339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9E5"/>
    <dbReference type="GeneID" id="116300462"/>
    <dbReference type="KEGG" id="aten:116300462"/>
    <dbReference type="InParanoid" id="A0A6P8I9E5"/>
    <dbReference type="OrthoDB" id="5985950at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="2">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565199.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21165" checksum="F4E091C76081E46E" modified="2020-12-02" version="1">MAVPYQFEPEIASGEEDNTQDESMSEESEQEELANEERRQGIDKWCTCQQCVVMETADMCLCCNELESRKYDNTQDSTCITTSEGFQCVCLNRDVLWTALVSLHDREGSSLPTRTNIPNNSLRYASYRQFTWWVHGYLGKKIRRVIPACVVSKIRSTFPNPNEEYTGFKEDGSEVAEVNLAWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IA22</accession>
    <name>A0A6P8IA22_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C9orf85 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561540.1">
        <property type="nucleotide sequence ID" value="XM_031705680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IA22"/>
    <dbReference type="GeneID" id="116297458"/>
    <dbReference type="KEGG" id="aten:116297458"/>
    <dbReference type="InParanoid" id="A0A6P8IA22"/>
    <dbReference type="OrthoDB" id="250548at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019351">
        <property type="entry name" value="DUF2039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876:SF5">
        <property type="entry name" value="CHROMOSOME 9 OPEN READING FRAME 85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876">
        <property type="entry name" value="ZGC:101016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10217">
        <property type="entry name" value="DUF2039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561540.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27059" checksum="88BD2383A827DA2F" modified="2020-12-02" version="1">MRKNIHAHIIDLSLRSCVQQFLENFRFLPKNVKFFSLIFSLRLTRMSSRKGDCKKKPQKYQNAIAFKNDLHDTSKTTKLINSTPVVGVCTRCRDAIEWRKKFKKYKPLKAPKKCVKCEQKTIKQAYHIYCTKCAQQGGFCEKCGEVKEILAQPEPSQQERAAQDSQLQQELKMLTERQRRTFFRHIEKGEPQDLTAIGGSLGSYEDEYDSEDEHDCLDDLTDLGQAGLKENVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IC69</accession>
    <name>A0A6P8IC69_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">carnitine O-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116300358</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031565076.1">
        <property type="nucleotide sequence ID" value="XM_031709216.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IC69">
        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="GeneID" id="116300358"/>
    <dbReference type="KEGG" id="aten:116300358"/>
    <dbReference type="InParanoid" id="A0A6P8IC69"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015909">
        <property type="term" value="P:long-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000002">
        <property type="entry name" value="carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032476">
        <property type="entry name" value="CPT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16484">
        <property type="entry name" value="CPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Carnitine O-palmitoyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="18">
        <location>
            <begin position="174"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031565076.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="87731" checksum="38A0CBE9FDFFA5FF" modified="2020-12-02" version="1">MAEARLAVGFQLQVTEEGIHLHFDSDAFKFVLRAMAKTAKRRVNDLKHAILKRSFPATPASWFVLVAALSAARYSEHQATLGVLRKLEGGIPGAHNLNQSTVIALAVLFVATVLWLLIGNILQFTLRQLLKYRKFLYEPRGKISFKTRCWWTLVKLFGGRNPSLFSYENSMPYLPVPDLDQTVQKYLESVEHLMDSEKYQRMEMLAKEFKDTVGSRLQRYLVLKSWWSTNYVTDWWEQYVYLRSRSPLMINSNYYGVDSVNHPTKVQSARAXNFIQALFYYRKQILKEKLEPQFALGIVPVCSFQFSRNFGTTRIPGKEQDRLETYNSATHIAVYHRGRFFKLECYFRGYLLKPADLERQIEKILNDNSEPLPGEELLPALTGANRTVWAEAREKYLREGVNKTSLDVIEKAAFVLFLNEEEMDYSEESSDNLDRFAHHTIHGNGHNIWFDKSFSLMVFKNGRIGFNFEHSWADAPICSHMAECIVTDDVKYLGYKENGHCKGEPLFENLPNPARLEWDIPPQCVDVIEECQRKSKLLISDLDIHIKVFNEFGKGVMKKCKVSPDAFIQMALQLAYYKDQGRVDLTYESSMTRLFREGRTETVRACTKESTIFAKAMMDPKKTKSERKELFQKAVDRHVLGFRQAMEGKGIDRHLFCLYVVSKYLEVDSPFLNEALSASWRLSTSQTPTNQTKRLDLSKNPELSTAGGGFGPVADDGYGISYIIGGEHLLFFHVACKKTAPNTNAKRFGNTIAESLKEIRDLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDN3</accession>
    <name>A0A6P8IDN3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane prolyl 4-hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116299131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031563625.1">
        <property type="nucleotide sequence ID" value="XM_031707765.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IDN3">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299131"/>
    <dbReference type="InParanoid" id="A0A6P8IDN3"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027665259" evidence="7">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="252"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="10">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563625.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="49647" checksum="37BBA78DBAEAA3E3" modified="2020-12-02" version="1">MVGKLVALVFLFLVIQTCCSNKYSKEANQQKTDDPGPCLDDGKPKLYRWDPVEVGHVRKIKLEGNKKYRIITRAKFPPIFEIPNFLTAEECDHIIELAKKAGMHTSDLHMDPITQDHMNRIRSTEGHSNSTAGYFLNWDANRDYEITRDEIKIFAERVKYLILEDQDIDEMIQNLDLKELEDGIITYPEWQTLRTNAIDMYFNDLKDHHPHHRDRYSKQVWLFQGKKSSKIMKTLRKRLWKLTKLPKDIIYGGEPLQVVGYDXRGHYNAHYDGTRRSDFPKDKCCHFDLLGVPYCRLCRYITVLYYLNDVEEGGETAFPVADIENFNETEFRDRKQGNLYNLYKYCHSANLVVPPKKGKAIMWYNFLQDEKTGWMGPRDDRSLHGGCDVKKGEKFVANNWLPAPEADSFHLRSDYLDDEELDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDV9</accession>
    <name>A0A6P8IDV9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC116299307 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC116299307</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563799.1">
        <property type="nucleotide sequence ID" value="XM_031707939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563800.1">
        <property type="nucleotide sequence ID" value="XM_031707940.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563802.1">
        <property type="nucleotide sequence ID" value="XM_031707942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563803.1">
        <property type="nucleotide sequence ID" value="XM_031707943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDV9"/>
    <dbReference type="GeneID" id="116299307"/>
    <dbReference type="KEGG" id="aten:116299307"/>
    <dbReference type="OrthoDB" id="5972871at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563803.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25412" checksum="9ADA269C7E676664" modified="2020-12-02" version="1">MKSEWEPFYVAVVFSEVERFLSDLAGASLSAEYEKRRLNLEKKISTVRKISPPPQLTTNVTETLQQKRPRRLRSWSFPPMTSQEPLLSLSGRNYVSTSTADSQDGGELGVALSNSSLKDEKESQDEEETFEETEMSLCNGKRFERLRQAYNSAVKIPPHPRQRSASVPHVSTAKQDHRKPNPEYIQVISSLSAFVCEKRKECERKPNKKGFNVAWRCGEEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEA1</accession>
    <name>A0A6P8IEA1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116299594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564125.1">
        <property type="nucleotide sequence ID" value="XM_031708265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEA1"/>
    <dbReference type="FunCoup" id="A0A6P8IEA1">
        <property type="interactions" value="1913"/>
    </dbReference>
    <dbReference type="GeneID" id="116299594"/>
    <dbReference type="KEGG" id="aten:116299594"/>
    <dbReference type="InParanoid" id="A0A6P8IEA1"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="11">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031564125.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22225" checksum="9C446FDFCD987383" modified="2020-12-02" version="1">MFGDKALELVKELKRTSDGTLPPYNEDVVRQVLEEMKALFEQNQKEVNATVAGESGLFSGVHLRHASLERDKRCLLVYIYNRMIRIKNFRWEFGTVLPEDVKYNMCEEEIKWFTKYNKSLATYMKSTGLDLTQDTKPPKSLYIEVRCVEDYGEFETEDGTVVLLKKNSQHFLPRSHCEHLIRQGVLEHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFA9</accession>
    <name>A0A6P8IFA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rapamycin-insensitive companion of mTOR-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565409.1">
        <property type="nucleotide sequence ID" value="XM_031709549.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFA9">
        <property type="interactions" value="1836"/>
    </dbReference>
    <dbReference type="GeneID" id="116300646"/>
    <dbReference type="KEGG" id="aten:116300646"/>
    <dbReference type="InParanoid" id="A0A6P8IFA9"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="53"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="523"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="887"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565409.1"/>
        </source>
    </evidence>
    <sequence length="1830" mass="204038" checksum="514B339CCAE9E592" modified="2020-12-02" version="1">MYGIQRNFSISGNRYDFFDEPNPLDLSKDPAENMHEVLQQITSKEDMSTTKRMGCVNNFTKLIQHVDEKANLGFSYEDIIVCLKVPLTMSAKEVRAAGLRALRHLFTDESKFLTMLKLRIDLFVVRSMDNNQAYEVERVQALRFIRKVVAICPRSCPMSLAATLVSTGSDDTEEADRLKRACLATLCELALKNTPLVSFAGGIQAIARNVLDCQMPRLNESLVVTLLYLVNNAKTRPFVPINVGLEAILAPFTDLHYRHSADTPESQLKEDKDGRLLASKMALITVFRTWSGIISFCKPDGKGLQSMLGVFCLQNSDVRKGIMDIISQIFRIKEPEWTDDFNVALLSVDPSQMKESWKLSEGFVAQEGLELLPRATRATARTNLVNNYTALVLSAFMNAGLFESLVEVITSSDCFISVRATILLGELLHLANTLLPPECSSHSHCLPTLVNTATSFEVSAAERGRASAAVNCLDRLHQMKKRGPVPCSLYLDQIVMQTRALEPKIKLDKLQKDRLLQCINKQDLEEPYLVAIRDSQVTMEKDFRNWDWDLIEASLQSPFMSLKRLEEISNQKFIRSLLNFFKPTCQQFCTVKLSDPQSKAFSRVGLLLIDFLLDPDDVMLVGSNILQELVQEIAECLQQVLSPNVSNGVLSDNNLHTYLSRDYFLFLGKLSSSKVGSKLLEKTGIFQYLLDISSSSHENLLKLIVSSLDYRESGISRIILSKILTASNFHSRLYATSHMRVLLRSKIAFFNNWGMEFLVTQLYDTDPRVASEAADVLDEACEDEANLQYLVQLRPVLLHLGDRGIRLLTRFVSVERGFSYLTSLGYLETLLDRWRQVCKIKTWLKLFYQCLKLLSSPLPPPQSSMMNDIEECVGIIRDLEPDSRENIIQIKAALWALGHCGSSNWGITLLVEEDVIPDIVRMAEECDDFAIRGTCYYVLGLAAKTRQGAEILTDQEWVSIRHMGNEEWPVVESKDLEIPAMVLASPTPSPTYSAFQLGKITEGSDNGIYLGEEPKKTADSSYDELSGIYIGEDKTASKKVGKEEKSEPGGILARWYADAERRRKIATRESGLYDDASGVYIGNERAPQKSLLDQENFVPGGIMAKLYQDAGLGKPKDSKHRRNLSEGNFSSSTGVLNEAGNEMDAKRRTYSNVDHTEPLNVEFSGSGMPKIQRQMSGIMMKHVHSSSATSEDSLGNDNREAKEGSDSNLETRNRYDSSCSELTVPIGHGRTDSNVSSISENSIDYQDTSSMDPSYGSIGDFYESPKAENRFKTRAMDDHRLINPPPLRLTARMSNDSVHTEEGKLSLDNDPRRAILTRQRSISMTEKKRTKSPTLALIAENRSSSFHGSTEFSKITSSKRSTSGMQSSENSTGMDDGLSSTSSNSLAEVKILSDKTIVFRTGVEKDRSLSFDSAQVSDLRRDRLLVSSQVSEPEMESGSLKTRSRTSSCEKAELARRLGLKSGDISQRSFGRSRSTSSGYGSEIYQRKKIINKNSLLGDTEHVTVSGDSNKNARSLSDVGKYTTMRDASGYVALSTLRRQYSLNKEALAPASSYNRPLYTAGPAVTDSTGLTARESLSSSTSSYEFRQLASSMASSSVGREFLGLCLPLNLSSFFQVEQYDYQGSWADHFISDPTTIGVTNNPEEPDGISDEHEPSRCLGCMYSKRTKSMSERRRSMDSMTDPDRISYRSVADEDLSGDSSSTSFASSVTYLGQENEEEAGSKNLDESSPRGRVLIRKTVLSLVVKLSSAVGSKSHQEGLLQLKSRFPHIFQDLCMFCEVVDLMSVYQFRLFIRRFLIHTLFNDVLFTEIHERADAIAYGGVAATSASTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFN7</accession>
    <name>A0A6P8IFN7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Substance-K receptor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17 18" type="primary">LOC116300769</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565555.1">
        <property type="nucleotide sequence ID" value="XM_031709695.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565556.1">
        <property type="nucleotide sequence ID" value="XM_031709696.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565557.1">
        <property type="nucleotide sequence ID" value="XM_031709697.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565558.1">
        <property type="nucleotide sequence ID" value="XM_031709698.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565559.1">
        <property type="nucleotide sequence ID" value="XM_031709699.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565560.1">
        <property type="nucleotide sequence ID" value="XM_031709700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFN7"/>
    <dbReference type="GeneID" id="116300769"/>
    <dbReference type="KEGG" id="aten:116300769"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="89"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031565556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031565557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031565558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031565559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031565560.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47918" checksum="476973595111D89B" modified="2020-12-02" version="1">MNTNTSTIAGSNFTTTSSLTTLFINSTSTMIHTTLSTLITTTFQPTTNETFSQANDTGRGPSCRTTPLDAERVFLIFCYIVIFVVTIAGNGIIIYVVNCYRNIKTAFNLLIVNMAVADILDAVAASPTSISFFIVGRRFPSGAIGEIICKLQMFIQDVSISASVLTLTVIAVDRYFAIVHVLRRPMGVRSVMRAICAIWVVSGLTFMYEFYRMRLVPYGKDAVTCTVVWGVDDPETVNLLFMTDMLMKLIFHYVLPLVVMIIVYTIILLHLWQRKAPGELSDNHQKRLERQKRKVIKMLVTIVTAFAVCWFPVHFNHVMITFHWERYRCALPMGVIMAFYMVAHANAAINPCLYLIFNQNFRDGFKHIFNKIHRRDITIIERTSTTRDVISNATAIPNIGYHPSTPQLTRLNASSSGDEMADSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFW5</accession>
    <name>A0A6P8IFW5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116300813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565629.1">
        <property type="nucleotide sequence ID" value="XM_031709769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFW5"/>
    <dbReference type="GeneID" id="116300813"/>
    <dbReference type="KEGG" id="aten:116300813"/>
    <dbReference type="InParanoid" id="A0A6P8IFW5"/>
    <dbReference type="OrthoDB" id="6022176at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="468"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565629.1"/>
        </source>
    </evidence>
    <sequence length="830" mass="94362" checksum="FF150CF7E1FC5D14" modified="2020-12-02" version="1">MQRPSLIPWRPPENDDTNAEFYDCEIGGKGDTLEFEEPKDDGYATILGLLRQRNALLLKLHELDPYQCVPSPQKANDSEFSRDGEVKSSECSTAMPKRDAEYSDTSGRATETTKNVYLEQQGYYWMTRNSPSYENEDCFVRGEDTLGQEYFGNIEDLIATLSQSNQELLNEVSYLQEEEQNSGVHNNFLEGDEGLSTKIGELIVKNKTLEKQLRTRDPLQESLQRQLQTFMERNLSATEISEIENIASMENISTGHRDKKEIKKDSETQTELNLLGNDIKISERFKDGEVGQLQERKTEHDLVNGQQGDEMVPKRDYDALEKELEDIKLQLSKANEEKAKMRENLDYLTDHYSKQDNMQRMHIEKIEQENKQYYNMLIEFQSGEQGRNRDIDSVLMQAERERTEKIASIAEQKVLRQQIENLSKTMKSMQLKNEELVRMQCSQEDRADDLKRVKQLFQESGLPTIEQIIALQRQNEAFREDILNERKEKERLLSIKDKLRRDLDSMQSRISSLQEQVYKYREHIFFLQQRTGKDGPTSPAPPSPLLETAPPPLNSSPSSTFHNPSRLYGSNAPQYINEGLLQGNVPPRFPLYAVSEAAKKGPPGKHGGIDGQPQGQGGGKQWQYQQQNNFPGKLGRHLSLDGDWKRSPQSWASPTDNIFNSSPAQRHNSSSSYSSVRSGSSDEDIDGLEKSNQFGRRHGARNGDDFKHLQNFGPTPSQFEAGWPRQNSAGRGIRMSQNPQRNPRRYSSPVGNGVRAPSDYWPQPMSASKQWQTSLEPSQFTDSAPPGFRQCSDPWQQSLSTTLPNSSQAPSVAVTSSHGDSGTYSGFGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHW8</accession>
    <name>A0A6P8IHW8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116301249</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566143.1">
        <property type="nucleotide sequence ID" value="XM_031710283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHW8"/>
    <dbReference type="GeneID" id="116301249"/>
    <dbReference type="KEGG" id="aten:116301249"/>
    <dbReference type="InParanoid" id="A0A6P8IHW8"/>
    <dbReference type="OrthoDB" id="6537982at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037746">
        <property type="entry name" value="Dok-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636:SF2">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="41"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566143.1"/>
        </source>
    </evidence>
    <sequence length="782" mass="88678" checksum="878F61E77EE87D85" modified="2020-12-02" version="1">MLEEVCARMFTSSKSKNSGFQVARWFPTLPAECIEDAPATMDIIEGPVRYRRKKKWKSRWAVLRRVNPAADVINLVLYQDQVGARSRQKEKAFISLESFSGLQLLNKLDKHYNVIIAITANEVVRLSFETIDERSEWVNCIQRHFGQEQSFDGIIPNKQKIKSGEATLRFYKDFFSLTRKDNYRLIGKWKLVDLPHYGAVYGAFAFEVKEGGGTCIYYFATKYGRELHQLFDNVCRGGQVGTENNYVEPPALDRSSPQRSVSQQDASVSQPNFFKRTWQRISQRRRTKQRPRSQSEPGENRRLRKLTNRRLPNVPGSANNRAGSTVPEVNNQHGSAGSTHLVTPDGYEIMTGGEEDDVVDAAEERKRKERKKSETTEEENPRSKASREEKSSTGEENEHDGYVIVDGVDVEKIIKETEKKLEEKKKMEEEQQKTAVKKSERTSENEDTMEPSYEKMEFKLNDVPKPDDKNGKPTTATESVKDESKIETEKKDSVKSGRNSEGYDNVDVAVTNENDIKTTGSDDVFKTEEIKPPKTPVRPKSLESKQELIVNPNKARRGIRNPPPELVLPQETPERPYVNSPPKTADYVNVPGRRGTGMMNSAIRSRSKTANNKPGSKKFNMYDIYDGNDDSIYHSVESLMPGNPAYQNLRVESNRSHSFDNIPGHSYTNLPGQSVDGQAYQNIGPPGTQAYVNLNAPKRKFQRNQNSHHLNYIQVEGTDGPSGQYGPPSFSIPAEQQNAAAAKAAGSEYTWIDESRTRLLKETARMHSDLRKENLPKVTKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II77</accession>
    <name>A0A6P8II77_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116301495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566429.1">
        <property type="nucleotide sequence ID" value="XM_031710569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8II77"/>
    <dbReference type="FunCoup" id="A0A6P8II77">
        <property type="interactions" value="3054"/>
    </dbReference>
    <dbReference type="GeneID" id="116301495"/>
    <dbReference type="KEGG" id="aten:116301495"/>
    <dbReference type="InParanoid" id="A0A6P8II77"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="7">
        <location>
            <begin position="78"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like N-terminal" evidence="7">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="8">
        <location>
            <begin position="365"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031566429.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="86163" checksum="3E3759B814693CD1" modified="2020-12-02" version="1">MAEAGKEKEMVEKTSDEEKDLSIPENGEHYTSAPSEDETVENLSEKMSTLGSEAQQPKYNWIDITEAFRESSIELKHGELVHDNMFGLFEAMSAIEIMDPKMDAGMLCNKTRKVVQFKPAVEAGMIKIKDFTSDELLGIMDQLMACLVTWLDGHSLVQTVFICLYMHDPFLIEDLCLKAYCIAILKCCEFIRIAVNTAQVFEEEDFQSMTYGFKMGSQVSETRTAGMLKEAEEEISRKLKNARIALKTETNSTDLQVEIKKNEAILARLKFLKAFYCAVVAIDKSECNGVTTAKQLLNTALTLVDPIKKTIQLGLTADLEKGEMLGFEPLVNQRLLPPSFPRYVLVFDREAAIDYLQLIVKRLIHVCSIVECNLLHMIIDFVSEFSKTHPCVLTRSNLQLMVWQNSKLFGRIPGVDVVRDAIKAFNSPPSIAEKSSLLNNPKAKEISDLFINRAVRSMKSVTHTLGHNRARQRDKLGQLLEEFASLQDEADRADAELHTLLTKYEPQRQHFACFGSWVLYHTLNIMVQYLTSGFELELYSPYEYHYIYWYLDFLFGWHMTCLNRAEKLLQAQEAALEQKSGRSGKKNKKKKKASEKAIQEHQGWRHLFQGMRYLCQGYLRALEGFEIDGKLKKPNFEFSSEQIRFERRFLPFQTVDTPQPMYYGHYQEFVDMSKAKDVKARDLFVLSANLFHQAKLIFDMVSISQEEVALVLKVSKTNLVVMKLAAGGHKQESLNVPTFEFSSHRAFPIIRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIE3</accession>
    <name>A0A6P8IIE3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasminogen activator inhibitor 1 RNA-binding protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566641.1">
        <property type="nucleotide sequence ID" value="XM_031710781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIE3"/>
    <dbReference type="FunCoup" id="A0A6P8IIE3">
        <property type="interactions" value="3018"/>
    </dbReference>
    <dbReference type="GeneID" id="116301688"/>
    <dbReference type="KEGG" id="aten:116301688"/>
    <dbReference type="InParanoid" id="A0A6P8IIE3"/>
    <dbReference type="OrthoDB" id="6022699at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="172"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566641.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44358" checksum="8CC6C57C5A0DDCAC" modified="2020-12-02" version="1">MDAVEYSIGVNNRFGLLADDEEPVDSVVDQGKSAKDKEKQKKDVRPVKDGKAQQSKKEKEAVNEETRKDARDNKKGGRPAKDGVKRENEKNTKLTNGPNREDRENIPPSRGGKGGFNRRKENEGGHPESDSPAKDDKERTGGMGFGGRGRVSGRGERGGGRGRGGFDRGRGRKREFERRSGSDRTGPEEGSRITSRSSVKPQEKREGGGSYNWGNATDTHEEEALDQEKRSNNWAESSPDDNKDKEGQAEEVEETEGEKDEAKEMTLEEWKEIQEKFRAKINYEVRKPGEGEKKGQWKNTRLLQKEEEDAQTQLMYEEKLKTSGRVKQKVTGIHFDFTSGDPKNQEPRRGGRGGRGGGGRGRGGGRGSGRGRGRGGGGGFGGGSREGGSTEFEINQEEFPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKM0</accession>
    <name>A0A6P8IKM0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116302211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567302.1">
        <property type="nucleotide sequence ID" value="XM_031711442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKM0"/>
    <dbReference type="FunCoup" id="A0A6P8IKM0">
        <property type="interactions" value="2336"/>
    </dbReference>
    <dbReference type="GeneID" id="116302211"/>
    <dbReference type="KEGG" id="aten:116302211"/>
    <dbReference type="InParanoid" id="A0A6P8IKM0"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19497">
        <property type="entry name" value="RecA-like_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000378">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059067">
        <property type="entry name" value="Znf_ribbon_CLPX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26040">
        <property type="entry name" value="Zn_ribbon_CLPX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="263"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="486"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031567302.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="67199" checksum="1DBA74314D9B5017" modified="2020-12-02" version="1">MFRVYSPLRSLRTTGGQMNAFKGSPSHILRTAPLRRIHIVTSNKLKSSPYLNGSHLSSQQHSPGSNGIHFQNSRLMSTTGGSKDRGGKNPWCCPKCGNPCSAVEASTRFVQCDKCSHFFLILSESDSKRYIKYESKSAMNESDKQQKVQKKPPPPPKKIFNYLDKYVIGQDFAKKVLSVAVYNHYKRLSVNLPSSSQSSSAEVKPIPLTRPFPGSPHELQLVMAQANTLNSPLGASGVQSSGQMKETSGSEILDAKRDRITLDKSNILLLGPTGSGKTLLAQTIARCLDVPFAICDCTALTQAGYVGEDIESVIAKLLQEAGNNVEKAQQGIVFLDEVDKIGSVPGVHNLRDVGGEGVQQGLLKILEGTVVNVPERNSRKMRGDTVAVDTSNILFVASGAFNGLDKIIRRRKQDKVLGFGAPAIEESISTEGKELNIFTNIKNDVRDDNAERDGLLSSVEARDLIEFGMIPEFVGRLPVVVALHSLNETALVKILTEPRNALVPQYQAMFAMDKIDLIIEPDALQLIANQALEKKTGARGLRAILEQLLLQPMFEAPGSDIVSVRITKDVVKGTKPAEYVHSPEKLNEDEATQPGEGTDIYNDDIEMYAGDASSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKX5</accession>
    <name>A0A6P8IKX5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116302012</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="20">Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567088.1">
        <property type="nucleotide sequence ID" value="XM_031711228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302012"/>
    <dbReference type="KEGG" id="aten:116302012"/>
    <dbReference type="InParanoid" id="A0A6P8IKX5"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006787">
        <property type="entry name" value="Pinin_SDK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04697">
        <property type="entry name" value="Pinin_SDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Pinin/SDK" evidence="23">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="22">
        <location>
            <begin position="134"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="277"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031567088.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40715" checksum="E8D8469DFD13E80D" modified="2020-12-02" version="1">MATVADLQREVEIAREGLKNVDENIKKLTGRDPSEFRPAPGGRRVSLKRDFAERSALARGYGAGXKRQDTQGRLWSRVVVTRTSQDGDRPSRRLDSDGEDEDEDTPKPTIQSSVVATTKTSLSLKREDIVQSDEKTKLRNRRMFGMLLGTLQKFKQDSACKTEKDVRREEIVKKLEVAETKEKEEVLSQKKELFSSRRAKQAELRKLEWKMELTALQEEWDEHGKKLCKFIKTKAKPHIHYVPAKHTDKTSKLLEESSRSAKRAMAERRAVIEEEFETQVEIEKTKEESNGESKGKEDVKEEQESPVRELGEEVEMENFEGESRSEGAVRETDGDTRQVIMKDENEESMDTGEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILP7</accession>
    <name>A0A6P8ILP7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuromedin-K receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116302525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567707.1">
        <property type="nucleotide sequence ID" value="XM_031711847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILP7"/>
    <dbReference type="FunCoup" id="A0A6P8ILP7">
        <property type="interactions" value="2156"/>
    </dbReference>
    <dbReference type="GeneID" id="116302525"/>
    <dbReference type="KEGG" id="aten:116302525"/>
    <dbReference type="InParanoid" id="A0A6P8ILP7"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567707.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42196" checksum="E7E830AA68AE1490" modified="2020-12-02" version="1">MNVTSNYLCFTHSLRNTTGTLHPKSWITSQEVSRIAFTVCYSILLFLAVVGNVFVVVIVCKNRRMQTNINFLIANMAVSDLTGSLVSIPRFISLNINNSSEWSVPGLLAEILCKTCPFIRDVSISVSIESMVVIAIDRFFAVVYPLKSKPRVTRLRWVLPIIWLVAMAPFSLYFVTFKIGYCKGKAFCIFSWPSIFDRAQVHHIYFLVTIVILFFIIPFAIVSVLHSFIVWKMKHRCIPGEQLCEQETRSQKSNSNIIKMAIVIVLSFFVCWFPYHTLTFFEVFVWKGYQKKSAPSFHSFTSDILTFISYISLAINPLICFVFSSNYRNCLKKLFPFSLFLFNKASAINVKTQRTAATHSQEMTNCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILQ7</accession>
    <name>A0A6P8ILQ7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116302693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567901.1">
        <property type="nucleotide sequence ID" value="XM_031712041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILQ7"/>
    <dbReference type="FunCoup" id="A0A6P8ILQ7">
        <property type="interactions" value="1830"/>
    </dbReference>
    <dbReference type="GeneID" id="116302693"/>
    <dbReference type="KEGG" id="aten:116302693"/>
    <dbReference type="InParanoid" id="A0A6P8ILQ7"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567901.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18196" checksum="EEA0E9CF368186BB" modified="2020-12-02" version="1">MAARRIGQYIPDWVKISARVPTEARGDMGRFRAAYESLKTSLESVPAKPETIDWEFYGKNVSKPGLVSSFQKAYEAVTVPYPKDTKSDLIAKREKEMETMCEQLKKESFSRIKEYEAELALVKSQKPFEAMTVEEYLQDHPDLRKQAAEEMKQHIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMA2</accession>
    <name>A0A6P8IMA2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Calcineurin B homologous protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567927.1">
        <property type="nucleotide sequence ID" value="XM_031712067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMA2"/>
    <dbReference type="FunCoup" id="A0A6P8IMA2">
        <property type="interactions" value="1893"/>
    </dbReference>
    <dbReference type="GeneID" id="116302705"/>
    <dbReference type="KEGG" id="aten:116302705"/>
    <dbReference type="InParanoid" id="A0A6P8IMA2"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567927.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18290" checksum="77721EFB49017706" modified="2020-12-02" version="1">MALDIYSLLFVYNFSREDFLHIPELAINPLGDRIVDAFFMSETDVNGHVDCNFKQFARTLAHFRPIDPNTANPLNSREEKLKFTFRIYDIDGDGKISKDNLMSILHMMVGVSISDDQLGCIADRAIMDAGCAQEQMISFEDLKKVMKNVDLSAKMSIRFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQJ0</accession>
    <name>A0A6P8IQJ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Partitioning defective 6 homolog beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116303870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAR6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569341.1">
        <property type="nucleotide sequence ID" value="XM_031713481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQJ0"/>
    <dbReference type="FunCoup" id="A0A6P8IQJ0">
        <property type="interactions" value="1550"/>
    </dbReference>
    <dbReference type="GeneID" id="116303870"/>
    <dbReference type="KEGG" id="aten:116303870"/>
    <dbReference type="InParanoid" id="A0A6P8IQJ0"/>
    <dbReference type="OrthoDB" id="5868434at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06403">
        <property type="entry name" value="PB1_Par6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000031">
        <property type="entry name" value="Partitioning defective 6 homolog alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000030">
        <property type="entry name" value="Partitioning defective 6 homolog beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034868">
        <property type="entry name" value="PB1_Par6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PB1" evidence="13">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="162"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031569341.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36187" checksum="4ABDB6879AEFE23A" modified="2020-12-02" version="1">MARLQKGTQKFGNITNLGTVEIKSKFDAEFRRFSSERNQYKNYEEFYKRVENIHRLTNTPFTTWYTDNHGDLLPINNDDNLQVALTSAKPLLRLFVQRKGEGYEQNGLPPEVQLRKKNIFSNIANVNRSSAYTNKVAISTPQDFRRVSAIVDVDILPETHRRVRLLKHNSDKPLGFYIRDGTSVRVTPNGLERVPGIFISRLVPFGLAESTGLLAVNDEVLEVNGIDVSGKTLDQVTDMMIANSHNLIITVKPANQLNNPKAGTALDRLNAKSRSLTNLNSIPSNPTGSPTIAHAYSNHLMGEDILDSDDEENPTVDESGVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQT5</accession>
    <name>A0A6P8IQT5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable serine/threonine-protein kinase PBL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569309.1">
        <property type="nucleotide sequence ID" value="XM_031713449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQT5"/>
    <dbReference type="GeneID" id="116303841"/>
    <dbReference type="KEGG" id="aten:116303841"/>
    <dbReference type="InParanoid" id="A0A6P8IQT5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF140">
        <property type="entry name" value="INACTIVE PROTEIN TYROSINE KINASE PTKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569309.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62977" checksum="A9D05FE42409EEDC" modified="2020-12-02" version="1">MAEGRTRPYSAVDCTEDSISMQGLIGKGSYGEVWRAKWNGKVVAAKCLHAELLHHDQEIRDHHAEEFRRESDVLRGLIHPNIIRFYAVLFPPTRSPVIVTELLHCDLQKYIERSTTTPKVLPDKAISISLGIAEGLEYLHGLKPPVVHRDLATKNILLTAEGHPKIADLGVAKVFAAGKDAFATVVPGTPLYSAPETFPAKKGLDFCTEVIYGVKVDIFSFGVVLMVIIIGQEPTVWPLSPIKAGSKNTLISEKERRKKDIVRMGNHKLKSLVLDCLHDKSSKRPTASQICKSIFKVHQELESRKNGPKPSTASCSGIIDTERNPCQGAASNSAETSTFEKIPSQFHYDYRFKVLLLGSSGVGKTCLVERLINPSYNIAYSTATLGIEPQSQAFQYNSSSVHMSITDTAGQERFFAIQPMYFRDVQGVFLVYDVMMESTFKELERWLDIVKQYCTECHVRVLVVGNKIDCFYQGKKIERNVSKERALEFARKHGFPYVETSVLDINLDTIMNMYKKMVECLIDAVSLNTIKIDMRDTMNKTNKVDLSTTENKETSHCKCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRK9</accession>
    <name>A0A6P8IRK9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304093</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569609.1">
        <property type="nucleotide sequence ID" value="XM_031713749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRK9"/>
    <dbReference type="GeneID" id="116304093"/>
    <dbReference type="KEGG" id="aten:116304093"/>
    <dbReference type="InParanoid" id="A0A6P8IRK9"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569609.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18040" checksum="594DFBA566F5C3C9" modified="2020-12-02" version="1">MTERRVAIAIDGSHYSERAFEFYCENLHHKNDLILFIHAFELPSMPAAPYPYGYAYYEEWSTLVQKADEEAKQLLESIGRRCQQKKLKFKLFKENGKAGEVICKFAHDEKANMIVMGSRGLGTIRRTFLGSVSDYCVHHAHIPIAVIPPPPEHSKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRT9</accession>
    <name>A0A6P8IRT9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 6 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569597.1">
        <property type="nucleotide sequence ID" value="XM_031713737.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IRT9">
        <property type="interactions" value="2551"/>
    </dbReference>
    <dbReference type="GeneID" id="116304082"/>
    <dbReference type="KEGG" id="aten:116304082"/>
    <dbReference type="InParanoid" id="A0A6P8IRT9"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056907">
        <property type="entry name" value="UTP6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24892">
        <property type="entry name" value="UTP6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 homolog C-terminal" evidence="7">
        <location>
            <begin position="306"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569597.1"/>
        </source>
    </evidence>
    <sequence length="592" mass="69491" checksum="FEADBFEA710861AB" modified="2020-12-02" version="1">MAEHVHQNLEGMLPELEEMERLGIFNRHEIRTIIKKRTEFEYCLQKRAPQKQDFLRYIQYEINLDVVRKKRKMSQGFKRTLKGEYEMSKRMHLLFKNALQKFKQDTKLWLQYIQYCKKTGSVKLLGKVFGRLLQYHPHIPNFWVMAAKWEFEENKDIPAARTLLQRGLRMNSSSQLLWLEYFRMELLHVEKVAKRRSVLGLAQLKEVEENQVTNAFLAGKAAEIVYKKAIEEIPDDIEFRLSFLNIYXLFENTKQSQDQVFESLEKDFGDSEEYWNALACRAVDDLKASSESKSLKESLMHEAEEERNRIFEKAVQLLPTEKMWDYYIDACETNLKDDSHSDQDRMAIENCLRICAEANSKDLLSKSKLKLWVRLLVLTGDTRTAVDVLEKKLSYKTTDCHAEYLRLLIALGESEDVLSEKFWDALKSTEGSGSLPLWELFLDWSMTVGRNNIARIFENSLKAPKHVSRVMQERYIDWVLTSSGIKQARHVYTRWFSDQSLPLSLIKKCVDLEKAQLKPSIQHLRTLYDVMIDHYGDAYSDCWIDYIHLELTHPEGKLDKAGRLHWSALKRLSGVETEVFVTKYSLIQAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITU5</accession>
    <name>A0A6P8ITU5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="36">Trifunctional enzyme subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="35">1.1.1.211</ecNumber>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="37">Monolysocardiolipin acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="38">TP-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="primary">LOC116304116</name>
    </gene>
    <organism evidence="43 44">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="44" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="44">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31179"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:31180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:31077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
            <dbReference type="ChEBI" id="CHEBI:62616"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:31188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:31160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:31165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31195"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:31196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31199"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:31201"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
            <dbReference type="ChEBI" id="CHEBI:62614"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:31168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43676"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83582"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:43677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43672"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83581"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43680"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:43681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:16107"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:20726"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:136757"/>
            <dbReference type="ChEBI" id="CHEBI:136758"/>
            <dbReference type="EC" id="1.1.1.211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:52657"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="34">Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.211" evidence="35"/>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031569640.1">
        <property type="nucleotide sequence ID" value="XM_031713780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITU5"/>
    <dbReference type="FunCoup" id="A0A6P8ITU5">
        <property type="interactions" value="1050"/>
    </dbReference>
    <dbReference type="GeneID" id="116304116"/>
    <dbReference type="KEGG" id="aten:116304116"/>
    <dbReference type="InParanoid" id="A0A6P8ITU5"/>
    <dbReference type="OrthoDB" id="10004768at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000011">
        <property type="entry name" value="Fatty acid oxidation complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000002">
        <property type="entry name" value="Trifunctional enzyme subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012803">
        <property type="entry name" value="Fa_ox_alpha_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02441">
        <property type="entry name" value="fa_ox_alpha_mit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="43" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="42">
        <location>
            <begin position="374"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="41">
        <location>
            <begin position="555"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="41">
        <location>
            <begin position="683"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" description="For hydroxyacyl-coenzyme A dehydrogenase activity" evidence="39">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="site" description="Important for long-chain enoyl-CoA hydratase activity" evidence="40">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Important for long-chain enoyl-CoA hydratase activity" evidence="40">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Important for hydroxyacyl-coenzyme A dehydrogenase activity" evidence="40">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00035854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00050222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00051877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00052834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00052860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00052945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00052989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00062153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00066806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00068347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00077617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00083277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="PIRSR" id="PIRSR612803-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="PIRSR" id="PIRSR612803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="42">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="RefSeq" id="XP_031569640.1"/>
        </source>
    </evidence>
    <sequence length="772" mass="83493" checksum="367DE4FDE0D03918" modified="2020-12-02" version="1">MLSSAVRGAVRRFSAQGGRRLLPSSNSAIFSRFQSNAAAATATSTDKYVSYKVQDGVAVVKFDTPGSKVNVLSEKLTREFEEVMQEVLHDPNITSAVLISAKPGCWIAGADVNMLLAGESAKKVQEISSNGQKAMQSVADSPKPIVAAIMGSCLGGGLELALSCHYRIAVNDTKTVLSAPEVMLGLLPGAGGTQRLPKLIGLPDSLDMMLTGKNIRAGKAKRMGLVDMLVQPLGPGLLSPPENTLHYLEENAVHAAKDLASKVIKPKRAKSWTNMKDIQYNLTTETSYGRNFVLKKAKETVMKKTGGLYPAPLRIIDCVREGLENGPAKGYLKEAEEFGRLSQMSESRALMGLFFGQTECKKNRFGNPARPVKTIGVLGAGLMGAGIVQVSINKGEHVMMKDNQIAGLARGKQQIFKGLNDKVKRKALTSFERDQIMSQVEGQLDYKGFEKADMVIEAVFEDINIKHNVIKEVEAVIPDHCIFATNTSALPINEIAKASKRPEKVIGMHYFSPVDKMPLLEIITTDKTSQDTAAAAVSVGLKQGKTVIVVKDGPGFYTTRILASALAEAIALLQEGVDPKDLDSLTKKFGFPVGSVTLADEVGIDVACHVAEDLAKALGPRLGGADIGVLKTLVERGFLGRKSGKGFYNYGGKRTLNSEALDILKQFKVPKKGSHEAEEIQIRLAGRFINEAALCLQEGILSNPVDGDIGAVFGLGFPPFHGGPFRFLDTYGAERFVNRMKELQQTIGEVQFQPCQLLQDYAKDPSKKFHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITV8</accession>
    <name>A0A6P8ITV8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dCMP deaminase</fullName>
            <ecNumber evidence="6">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116304817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031570469.1">
        <property type="nucleotide sequence ID" value="XM_031714609.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ITV8">
        <property type="interactions" value="1239"/>
    </dbReference>
    <dbReference type="GeneID" id="116304817"/>
    <dbReference type="KEGG" id="aten:116304817"/>
    <dbReference type="InParanoid" id="A0A6P8ITV8"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="317"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031570469.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="52096" checksum="73C6F81D0AF0EF3F" modified="2020-12-02" version="1">MHGEDEDLESLEYSSAGYEKQLPRISKPDMFMNTALWIEIEDSPEGESLKQGNPVRAAETGERPLKPVKKYHKAGAVVVLPNDRALSVDCSHRGIHAAVSALNKFGQERAEGCQVYLSRRPCSFCAKLLVQCEVAKVFYLPIEPELNDKEDVRKVDRLFKASSTGLSVYIPKVSDTILKAQRKRHSPFLKNPRNDLEIIAYRDLLKKEYWSTDWINNASTVLEWPAFKDPNMQKQTNEDMENLLEWIATATKGDVPDYVKFLEIDPHSSPLTEKKSKEPKGAEETTDGIVNYDESKAIRTVSTVLPDPTVGDSAWQKHALHMCRMAQMLSQRSDDPTAPVGCVLMMHNQVTAIGWNGFPAKALYGEFPRASDNDDSREKKEXYVIHAEQNALLTRNVKNMDHESSVLYSNKIPCGECVPMLIQAGVKNVVVPQESRRDVAENEVFTEAITSKMLKGFWPSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU03</accession>
    <name>A0A6P8IU03_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial ornithine transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116304145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569673.1">
        <property type="nucleotide sequence ID" value="XM_031713813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IU03"/>
    <dbReference type="GeneID" id="116304145"/>
    <dbReference type="KEGG" id="aten:116304145"/>
    <dbReference type="InParanoid" id="A0A6P8IU03"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000294">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF58">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="188"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031569673.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="32074" checksum="3CB74871F411FBF5" modified="2020-12-02" version="1">MTHNEKRIGWLQEGMIGLGVGVLYGTTSVAVGHPFDTIKTKMQAQAGFEKTSMIKSFVKTLREQGIRGLYRGCVPPLWGSGIYRSTQFAVFEAVYTMLNTRNGIREIPFTGGIQIRVLVSGAFASTARAIIETPLELAKVRRQTGQTWHFKSLYRGFGVTWCRTMGLMCTYFMLVDSGRRHFPEQFKKPLLGPFLTSGIAATLGWWVVWPLEYMKSQVQGNYGKDLPVITRMRLVIKEKGGFFGLYRGILPGSIRSFMSNGCSMIVMSWAQRKVSEWGLREQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVY9</accession>
    <name>A0A6P8IVY9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571481.1">
        <property type="nucleotide sequence ID" value="XM_031715621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVY9"/>
    <dbReference type="GeneID" id="116305663"/>
    <dbReference type="KEGG" id="aten:116305663"/>
    <dbReference type="InParanoid" id="A0A6P8IVY9"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031571481.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17019" checksum="74D3CF8F060F2593" modified="2020-12-02" version="1">MVDKLTEEEIAEYKDAFSLFDKDGDGTVTISELGTVMRNLGQNPTEEEIKDMIKDVDEDGSGCIDFNEFLELMANKTKGTSYEDELKGAFKIFDADGNGSITVEELKQVLDNLGERLTEEEVGEMIKEADTDGDGTVNYEEFIKMMLAMSGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWI0</accession>
    <name>A0A6P8IWI0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116304767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570408.1">
        <property type="nucleotide sequence ID" value="XM_031714548.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IWI0">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="GeneID" id="116304767"/>
    <dbReference type="KEGG" id="aten:116304767"/>
    <dbReference type="InParanoid" id="A0A6P8IWI0"/>
    <dbReference type="OrthoDB" id="5956899at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039889">
        <property type="entry name" value="CCD33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623">
        <property type="entry name" value="SPERIOLIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="203"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="666"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="736"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="892"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031570408.1"/>
        </source>
    </evidence>
    <sequence length="966" mass="109402" checksum="2883EACB4EF0D750" modified="2020-12-02" version="1">MPDASDPLYFDVDIYKALFNNTGQYFLKIAIQGSPEKQNEVKLYINQSKNGLHQSQYVTDACFQGDTGEPIMFPDSKITFYIPQGFVEQEVFLIAEAYELSETQQKCGEAAFLVYPHRSSLFPTKVAPENRADEKHVLYNTEKQLTLTTAESGLGGMSVSVGVLWMKAVLRKADQEDSQEQNIVPTSAGKCKPTPYYLVNESPLGPLSSIVHPRHLCGSYVAREGYCEVAVLVHAAIGLPSKSDGRPPQPYVIGKSKRDRSRGLPSRSITHTSIQPTHFPTWDEVLLVEFPQEDFKQEEVHLCIADSPSKELLAEYRIPVSQLKPFYPYNLELVKSNNNLGNSSRLYVSFILKFDRLSKPDNNSAKIYGMEVLLRGFESPISNQVGPLIAVSRIVPDWDEYREKMLTSHPCTASVTMTTIGFPSPHPTSFSVASSSLLYGSPQVTVCGEPFHQPYWNQMFYFPGDKESLFSKKASMVIEFYTASQAFSDSGWQLTNAVGYCNRILNQPLAFALQQQNASMGLRLNNLPIQGFMKTPTGRKASAGIVLRLLSQERPDGLASASQFSSLPVFNENPEMLDPEEHLAEQPNMTTEKNPYGLPPFDXVQRILPLSKPKDSSDLLMSQSFQQPLKNDRANSNGDPVAIPLELRSTMDLRTLALLDYXMKEVDRYRTAMRKLAADLLHLKQENARLEEANSQYRRDLNQHDEISRIMVGSNDLDNVTHSELIQKFVMLKKKLSDESTKRQELQKRTQKLQNDLIKKNEKEKELLKLQAAHESQQALLQKIQSKAQKYKATQDACKKQEKVIVELEKLLANGKNEMNLSDNREINGVYIEENARLHLELEQYKERQSAQNTKQQLLRTASPDMETMPSSEKLELYQKLERSEGRILGLEKQLAENARKWAKEKTKLQAKLNEMVLEQQAGFPSHFGQDARYTPDVNFNPSTNVLFSGTRKPSPKLNPLERKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWY6</accession>
    <name>A0A6P8IWY6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein KIAA0100-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570470.1">
        <property type="nucleotide sequence ID" value="XM_031714610.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IWY6">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="GeneID" id="116304820"/>
    <dbReference type="KEGG" id="aten:116304820"/>
    <dbReference type="InParanoid" id="A0A6P8IWY6"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2110"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2263"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1870"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2115"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2140"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2263"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2294"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2334"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2348"/>
            <end position="2357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031570470.1"/>
        </source>
    </evidence>
    <sequence length="2357" mass="266715" checksum="B9F3E86947739BD2" modified="2020-12-02" version="1">MVLSYAAAFVLLAIFSAIFLGRFFAKVIEVIARCFVKLDLTIETFGFLSVIGIKIKLKNNNIIEIENISLKTKWTHSNSRKLFTVYFGKTLITQEGSIAKQPKPNVKKKGPNNNFMNSHKERISQFINLFCQYMAISFSEIVVILRQSDNRIIQCKLQDGLDISANPTGKCLNSVILMNKVVTELNCVTDKSSNTYENVAAISVDVAIEASIQPLEGISSADIQLSLRSLCVILNDGLLTKNKQPEAGPSVSHLDEVENRMLHREENSEQLATTNLWSRLAEAPKQVELSIEKSSINFINKDKRNLNIDITRIFSSFVRDQGNGNDTSKQCDINLVISGINVSGSQSCRLCIMNRFRFVAKLSEQDSIPQLATSVSIESFHNSYIHDDYMYWMEYFMSQMGKRQSAKTAAPQSTSSKKGSPFNASTKLDLELIDCSTCFYLTHKYGEQPLCRAVLASFTTSLKIPSLDLVETNLGVQDISVASRMENAYVYFDVLTAVPESLDNADVISYTLPDNPCLLPNTNNHVWGRVLAMGSCSTQCEITLPHKDVSSLHVSIRGEASGLALEWSHQVCKTILQITKQFTQGLSTVKDKREHRKPTQKTKISLDTDVRLCGINIFYLGTRADGVDSFVYRTDMVLSTFSSGRPVLMDIFGIKVSRMLGLKREPYRCLLSKEMNNQCVSVPAITISLANHKVISLSLQDTTVDWNPPLHMALYDRLQEVTQDVMGMKEVFVISGQHEIEEERQESDEKTQEAPKGFDLKCDISYFKLQMETSPSTSFGVEMRKSSLELQNSDVTVAMDTAVMLFDDKDTFTFKGISIQRSQEVEVIKNLRKMFTNLQTLNNTTWIIAVHSTTVFFPYQFDFASSRSELVNVTKMLKALHKKTRDASYVEPLPPDLWLRFEEITLEIEDDPFEVKLGDNYALLQEEAKQWIDREETLENRLQAIRMTPGNLLTVKKEEMLFQKLLEKNAELYXQRSKALYSKTPMRRNLLVWEFASLDLKILADESYHGKVKAVEMMNKLNSESTLPSGLEFSTLWCRTVKGTLDSHCCRLRDYPRPIFTSKEVKLCGTFLGAEQAADNRAKYNSSILINEPWGDMTVQRSLTALKFYYDIDFDMDTLELAWGVDIDPAIAMVSLAFGNLSKPSKDPSKPLPFYDKIRLLLHGRLHMDIKKWLMFYSATRNPYNTTERLELDWMNVDLLWTNGRIEIAGDFTLQTRTASRYDDREVLHFPAFKVCSDMQWNCSGDANDHHSIMPFAPSKLPELAPNKVHDSYAPFRSQSLTLHLSLETAMDVTKDLSQLGSPYICLYASTLRWFNNYQEVVLRNTSRPIKRGRYFNRIPPKRQTLGRHYKEVSLSLKFPKLSVWYWGSFSQQRGFEMTTGSGSLHTQYRLALRPFEGKLTRRPAADWTASKLHIEIRDITCHLYGLDSTENLEDGEQPEVSSIDLEPNKYYFLTTESLEYSRQDASKQQPRVDESEPDSQSYVHQLVCHGSKGVWTLTNRKIIFGLFEAYTNAEVLKKNLSADAVKITIVDKKQQKTIKESPGVVLHKKRSMSLLQKLVNEKDSKFTVFTEEGTGTVEAAETPLQGVSLCTSEDFIAHTWHIKLVNTQILLQGTETKGGVLVTAGNATVLNRLHRPVWSKTELLNKKTWVGTVENLQYFATVSPDDCINLNNIPWLDTTVITGRQSQEKTGFDIADLANIVGSGEAVGGVVTSVVGGTTTGAGQDIPQLQRIVARCGCEFYFVNFSTELDPLAEGAAPNSVPQSPASSNHLRVNRLPTVDTYTVRHKLLEISTNSSQYLMLIDIVNNVVFYTEPKKKEANERLQKMTFRLQLSAIEDQRAQILKQQNIVRHRQTEMRGLQRQLYELNLIRKQALDNQGLTEAMIQLEREITQKKELLNSASTELRLLISAYKDFQMNLNPPTPEKAPSSEPTKLAEVHFNHASWKLNQADGQLEIADATFRNFSYSKTTLSDATIEHRFEVPKFNVRNLLPNSIYKDVLTQRIASGQGQKDRAVMVRLYCRVKPPVGGIGVKEHLEINVCPLSVGLTYRLFRKVMAFFFPQREHEYDGDTGEVDLIYKGAEQELDKDFEDGELFVDDLEDNFGGGRSSNLKRCASTXSSISSSSDASTDSAATKSRKSMTSLVSHTNAGPSASQAKDKGKKKSMFYRPLDDHDDLEKMKERASKNHSFIYVKVTEVLMCVSYKGEKEKNIVDVHNFNLTLPTLEYHNRTWTWHDLLIAMKKDCINVLVSQVIKEKLHLKGRRDVDGTENKDSKSEPKEEDKAKLLFGDTSKTEKKKKSKKSLLGKLVRKTRLSPRPSGLLQPDGAGPEPVNLEGEEYEQSEEEAPDSDSSLFDTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYT7</accession>
    <name>A0A6P8IYT7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Apelin receptor A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116305360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571113.1">
        <property type="nucleotide sequence ID" value="XM_031715253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYT7"/>
    <dbReference type="FunCoup" id="A0A6P8IYT7">
        <property type="interactions" value="2156"/>
    </dbReference>
    <dbReference type="GeneID" id="116305360"/>
    <dbReference type="KEGG" id="aten:116305360"/>
    <dbReference type="InParanoid" id="A0A6P8IYT7"/>
    <dbReference type="OrthoDB" id="6022667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="52"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031571113.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40979" checksum="50AC0E01C4A850E4" modified="2020-12-02" version="1">MDAAREQIPNGNHSFLNSTSVNPPICFAGEPLTLKSARVMVYIVIFLVSLMGNLITVITVQRTSRKRKFVHLYLMNMAIADLVITVVYMPRTMVRFFYGFEWLVEGVPGLVLCRMVSFLHHASILASIFSLFGTAFDRFCAVMYPLKRITTRRVAITSLVLIWILAGILRSPFLISPNVRFSSEGKPPLRICSSGFSNLFGQRLATLYRGFFIVLYIICLVLIVILYLIMIGKLCRQKSPGNNEEATKARQKAGKRLIEMLISIAIAFVLCWLLYFIAIPIHGSSDLPCHLSFFTYLLAHSNSAVNPCLLAFFDSEYRGGYTYLLRRMSLCKSMDKQFTSGKSQPKKEEKQEPDNKTNATKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ58</accession>
    <name>A0A6P8IZ58_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572472.1">
        <property type="nucleotide sequence ID" value="XM_031716612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ58"/>
    <dbReference type="GeneID" id="116306531"/>
    <dbReference type="KEGG" id="aten:116306531"/>
    <dbReference type="InParanoid" id="A0A6P8IZ58"/>
    <dbReference type="OrthoDB" id="5955141at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027953869" evidence="2">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="139"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572472.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33583" checksum="E36D9677AAFF039E" modified="2020-12-02" version="1">MSCLSIQHCGIFILGILIRFSSSIEIRQITFNIPVKNMKLTNHEIAYLRVGSQDVCMEACFLDPNCVSINYYPTLEESYENCELSSSDDYLCPEDFVFSKGTVYFGIQNQCHGAKCYEQNMTCQSGFPPEGYKCVAPLCYEGPLGMEDKRIPDSSISASSEYGKGTYLAKNGRLRSKCNKCVWAAEENKVGEFLQVDLGHKMVLTKVQTQGNVWMKDQKDEWVTEYYIAYSQDRNHWQNYTKDGNLTIFDGNNDGYNVVTNDFNPFIRARHVRIVALDWKGHITLSAELYGCKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZK7</accession>
    <name>A0A6P8IZK7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">T-box transcription factor T homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116306669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572607.1">
        <property type="nucleotide sequence ID" value="XM_031716747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZK7"/>
    <dbReference type="FunCoup" id="A0A6P8IZK7">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="GeneID" id="116306669"/>
    <dbReference type="KEGG" id="aten:116306669"/>
    <dbReference type="InParanoid" id="A0A6P8IZK7"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20192">
        <property type="entry name" value="T-box_TBXT_TBX19-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000002">
        <property type="entry name" value="T-box transcription factor Brachyury"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002070">
        <property type="entry name" value="TF_Brachyury"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF106">
        <property type="entry name" value="T-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="9">
        <location>
            <begin position="50"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031572607.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44153" checksum="25A0B593A707D21E" modified="2020-12-02" version="1">MHSDEKKPSAFSVNHILQAAESSMADNNASRESNNENKITSDESQVKIILEEADLWRRFKSLTNEMIVTKNGRRMFPVLKVNVTGLEPKSMYSFLLDFVCVGGNRWKYVNGEWVLGGKPEPPTPSCVYIHPDSPNFGAHWMKQSIGFSKVKLTNKQSSSGQQIMLNSLHKYEPRIHIIKVGASDNNRTIVSHSFPETQFIAVTAYQNEEITSLKIKYNPFAKAFLDAKERQEQKEAYEQSETHSAYSQCGWFCAGPPPVYSHHHHHPSSYPHISASPYRGISQLGIRSHRPAPYPNPYYKRADLSPPGIPQQYYTQESNQLIFPGAPTIDNLAIPTTVGHHPPSGLSSIGGSSPYGRVSHDLDNHRRETTEKSKHLQNGSLTLHPAWTTIPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZM4</accession>
    <name>A0A6P8IZM4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fez family zinc finger protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116305447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031571205.1">
        <property type="nucleotide sequence ID" value="XM_031715345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZM4"/>
    <dbReference type="GeneID" id="116305447"/>
    <dbReference type="KEGG" id="aten:116305447"/>
    <dbReference type="InParanoid" id="A0A6P8IZM4"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031571205.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38243" checksum="33C1FDDB44F37D12" modified="2020-12-02" version="1">MPKAFLLKRTFMKADALEWPSPLSPHRVNAKVDSDVGKGFRSKILRENKAEKVDVVSQRKGKFSYPADVCVGGSLDNTAKNLSLETDFINNKKNPSGCIDAARNHSKDVRLKYGEKSKRCRTYDDSDSSVHFSSSGEEDEPQTNCIGINKAGKQKANQIKKDRANKAIHRCDQCGKIFKTKYTLSIHLKMPDHTESRPFVCNICGKGFRLSSTLCRHKIIHTQKKPHKCDTCNKSFNRSSTLKTHIRTHSEKKAFVCDICGKGFHQKGNLRNHIMIHTGEKPFKCTKCQRAFNKMSNLKFHMHTHTDNLPYQCKVCRQRFSKKHELKQHNDEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J059</accession>
    <name>A0A6P8J059_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116307190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573201.1">
        <property type="nucleotide sequence ID" value="XM_031717341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J059"/>
    <dbReference type="GeneID" id="116307190"/>
    <dbReference type="KEGG" id="aten:116307190"/>
    <dbReference type="InParanoid" id="A0A6P8J059"/>
    <dbReference type="OrthoDB" id="5980076at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
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    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
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        <property type="entry name" value="7tm_1"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031573201.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="44604" checksum="B001315F90707027" modified="2020-12-02" version="1">MALKMKTNISSSNSSSNLDRNAFIYSTEASIIQTVSLVVIVLCGLADKRPKLCLVGIWIICAMVSFIALGPFSGWDYMTFNSTTAHCGISFPVSITQKFRLAVLATTAFIIPLSLMTYAYWRIYSKVNHHERRLSNTGTINIRKIIPVKKKLTITLCLMFGTFVTCWSPFFLLISMAICLKSPSDLPNALGRFAYWFGYINCCINPVVYCMRTSTFKEMMRGRSTSLQTLERQPRKRRAQSLPILSTKNRRMSSISIAIRPAPETPSRLFFDTSSSNSSQSGTPNVRVHRKRAFSWTANYTVAEAIEKDIQESRRIAQRELRLPLRNTTKRMIFSNKSVRTSLPPTIVESPLEATNDVENIHMPCSVTFLPCMEIVPRDKKMSSYQNETIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0A7</accession>
    <name>A0A6P8J0A7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neural cell adhesion molecule 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116306903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572897.1">
        <property type="nucleotide sequence ID" value="XM_031717037.1"/>
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        <property type="interactions" value="1300"/>
    </dbReference>
    <dbReference type="GeneID" id="116306903"/>
    <dbReference type="KEGG" id="aten:116306903"/>
    <dbReference type="InParanoid" id="A0A6P8J0A7"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="73"/>
            <end position="162"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="166"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="258"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="501"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572897.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="61331" checksum="DD29DB49AF9049C3" modified="2020-12-02" version="1">MNESDSLSIKCDADGYPPPTIKWKTPSGSVYPGKIYNIPSISTLHAGTYTCTASNGIGREAVASIQVTVQHKPAIDLSKSSFSSKSWNGNSIRLRCFATGLPAPRISWYKPTNQQITTGVNIVPGGGSEVTVQTTADQGDYGQYKCWATNILGSDEHVINVTQLVAPGAVTLTIIEIEASSANVRWTKPADDGGSPVTAYVLETDSHIFVRTIDTYIVLTGLKKDSRYRVTVYAKNDIGYGVSSTKMITTKKKGRPDIPELLTSLLIEAESKRKVLLTWKKTDDNGATISRYTIYMKEEKEQPDWNIIEDVKDSLLLECIVGTKVKYGKTYKFTVTAWNKYGESIKDERNVKTVNTTADKTAYATGKSVNSCPMXGSKYITTVLGVIIAILVLSLGLNLLQFLWWRKKDRLHCLKRKQGNQRTKKAADEEIYSNELEMDKKVISAVTTSLPHPPINTGPEYETIQQLNEIASPQEEIPPNHLKHYEDLNLPNPSEQGXQRPVYEPLRTRSVERNVRLDNNNEQHPYEPLNIRNQNPTYQSLQTNSSEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1G9</accession>
    <name>A0A6P8J1G9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573392.1">
        <property type="nucleotide sequence ID" value="XM_031717532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1G9"/>
    <dbReference type="FunCoup" id="A0A6P8J1G9">
        <property type="interactions" value="1497"/>
    </dbReference>
    <dbReference type="GeneID" id="116307344"/>
    <dbReference type="KEGG" id="aten:116307344"/>
    <dbReference type="InParanoid" id="A0A6P8J1G9"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="124"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573392.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43524" checksum="BAC0EDBD1437210F" modified="2020-12-02" version="1">MDLTFKLKNAFQGLSTEARELYLSSEVPVLSAPPTSLQFYRQWVSPNIPVIIKNAINHWPALKLWNSDYFREKIGDKEVTVAVTPNGYADAVVGDRFVMAEDRSMKMKQFLDILDHKTEEKGIFYIQKQNSNFTEEFSEIICDAELDIPWTSEAFGLSPDAVNFWMGDERAVTSMHKDHYENLYCVVSGTKTFILIPPTDAPFIPHGLYKPAKYEYNLKGDFDIVDVEDSTQEDKEVKALLQDELPEIKDIHGKNQRDDVNNLEKNHCEGDKEVDDDDEVDEDDSADVDDREMENENLTPWISIDPLNPDLETFPEYAKARPITCTVHSGETLFLPSLWFHHVQQSHKCIAVNFWYDMEYDIKYSYFKFLEKLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5X3</accession>
    <name>A0A6P8J5X3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein OZF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116307274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031573298.1">
        <property type="nucleotide sequence ID" value="XM_031717438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307274"/>
    <dbReference type="KEGG" id="aten:116307274"/>
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</entry>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031575412.1"/>
        </source>
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    <sequence length="168" mass="19559" checksum="081E98CB6B2112DA" modified="2020-12-02" version="1">MSLAFKTPDYGKNRSSKSKKKELGEEQKQEIKEAFNLFDTDKDQAIDYHELKVAMRALGFDVKKADVLKIMKDYDRESTGKIAFDDFNEVMTDWMLDRDPQEEVFKAFRLFDDDDSGKISIRNLRRVARELGENMTDEELRAMIDEFDKDGDGEINEEEFLAIMTGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J899</accession>
    <name>A0A6P8J899_ACTTE</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </dbReference>
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        <property type="entry name" value="DEHYDRATASE YBIW-RELATED"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="10">
        <location>
            <begin position="384"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="9">
        <location>
            <begin position="1102"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="8">
        <location>
            <position position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574028.1"/>
        </source>
    </evidence>
    <sequence length="1224" mass="138124" checksum="0EB62648A8093F8A" modified="2020-12-02" version="1">MEDQVLRKAQRGLFFGKPKSGIFVNAFYKKNLTVDDPAVRDGIVSAVRDVVNYASQVEEEGGNASRTRAIVAFDPNQWSKWYKDDPRLSNLEQREKGKKLVPDSQKFIDTGGDVYFLLKSDVKDELEKVLDYIQDKMKDYFSDFDVTRSQPPSKRILQSSFTDGVANPCDAESFKTYIVKNEGSSVGYPGSTYLLTQKFEFNWVVLGNLDKIQKEDMIGRKSGTDTFIPHTDKRSHLMCAHVVHDVPPVNVLKRHPRIFRVSMPYGQIENHPGREEGLMYLHMCNSVETFKTILKNIAGNDKHSKLGDVTIDALLSSVQPLQGAYWYVPSAEELKLPTLQERRFDILDFWNKRSPTNEYLFYNQKEYLYRMTSGGYTPGDPPSDRVLRLLDYAFQQWNDQWFKRREMPKFPHLFETLKSPKKLELVKNASVMIRKGWAMKICLGRLCTTNKKHKLESRKFFGNKADVFGIHPDELIVGRMPPCFSLGLGKTAMPYLREEERMPAFIKGLSEAAGIGHVIPDYETLLQKGLQQMKREMKANMGTTKEEKEFFQACILALEGVQKYIRNYGFHAGYLANRKDIELSDAQRENMKQIEARMKKISTDRPETLIEAVQLLFAFHCCLHLSGEQTSIGRLDQLLEPFIDGTPSEQAQEIIDCLFVKLCEHVHLNTRLLNELLEWGMNAVPYSSTGMFPNGDTINQWVQQITVGGYKANDESVPQDGCNAITIMCLKASRRLPLNAPCVSLRVHKDMSQEVLQEAAKAILSGGAHPLLLHDDRLVEGLLKAGTSDVPVSLRSARNYCCDGCYEPIFPGETDFSLAYVPLLQVLEMTINHGSTYLVAGSRFLEGAPQSLPTEHPEDIYSFEQLLKIFALHLKVRTEYNIFLLLLNYGNVVEFCPSPLLSSLIRGCLETKRDIYNGGANYTLIGVQFITFSNTIDALYAIKKLCFDQDSAVIPLSEMVRCLKCDWGYNMQEPFHDELAGATRGQRLSDTYKEVRERALNLPKFGTSEGAENKDIQNIASWLAEQVSTVIQKVARDAPDGQPLKDLISGLKKKYSVPGVPWDVFLPTGSGTFEGYVGWGGSCGASADGRRAGSFIASDCSAAPTPLDKPPVPKSFEISKSLKSWDIPSINVGFANGAPIDLKIDEKFKESDLITFLKNFADDKGIGGNILTITCANPETYANAQSNPEQYDLIRVRTGGWSEFFIAFFTEHQKHQERRIFYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAV8</accession>
    <name>A0A6P8JAV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cannabinoid receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573940.1">
        <property type="nucleotide sequence ID" value="XM_031718080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JAV8"/>
    <dbReference type="FunCoup" id="A0A6P8JAV8">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="GeneID" id="116307776"/>
    <dbReference type="KEGG" id="aten:116307776"/>
    <dbReference type="InParanoid" id="A0A6P8JAV8"/>
    <dbReference type="OrthoDB" id="5949920at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573940.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34125" checksum="B28CBDFCA00224AB" modified="2020-12-02" version="1">MSQLNQCYEKDIKMDEFELYFEIPLITLYVITSILITIFNFLVSLTIIKTPSLRRSPSRILLASLTVNDVLIGAIAHPLYIVYCIAALKKSTSVFCIIYLVNIRITYSLETISLFILTVISIDRYLAVATKTAYKTMVTAKRVKMVVLSLWLGIVLVIFTVLQFGSFDILLHIGVVTAVTILTTITFCYLGSYVILKKLSKVSNGCTENQRTSDFNIIKYRRSLNNMLIVLVMTLVSYVPVVVVAAVNVIVDLENKVFAVHVAQSLTGFHSVINPLFYVWRMNDIRSGLKNLIKKLIDLFGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2K9UYR2</accession>
    <name>A0A2K9UYR2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Globin-1-like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Globin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC116292925</name>
        <name evidence="9" type="ORF">A.tenebrosa_nvec141000032_2</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Evidence for a large expansion and #subfunctionalisation of globin genes in sea anemones.</title>
            <authorList>
                <person name="Smith H.L."/>
                <person name="Pavasovic A."/>
                <person name="Surm J.M."/>
                <person name="Phillips M.J."/>
                <person name="Prentis P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12 13" key="2">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KY810203">
        <property type="protein sequence ID" value="AUV50082.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556128.1">
        <property type="nucleotide sequence ID" value="XM_031700268.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556129.1">
        <property type="nucleotide sequence ID" value="XM_031700269.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556130.1">
        <property type="nucleotide sequence ID" value="XM_031700270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2K9UYR2"/>
    <dbReference type="GeneID" id="116292925"/>
    <dbReference type="KEGG" id="aten:116292925"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013314">
        <property type="entry name" value="Globin_lamprey/hagfish"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01906">
        <property type="entry name" value="FISHGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AUV50082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556130.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20102" checksum="56065E6082388A89" modified="2018-04-25" version="1">MGCSSSIDRHQRRVNPDPIDIPLSKAQKYLVRETWETVELYKNNVGKQTFLRFFENNPEFQKLFPEFKELKYEELQKANALHGHAKRVMKAVENAVSAMDDAVSFSAYLEELGRRHVARSLKPSYLDAMQAALMDSLRQTLQSEWTDETAIAWNKLFRFIADTMITGLQSSHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-12-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5J6CZN0</accession>
    <name>A0A5J6CZN0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase chain 4L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH dehydrogenase subunit 4L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ND4L</name>
        <name evidence="15" type="ORF">F7P26_mgp06</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="13 15"/>
    <reference evidence="13 14 15" key="1">
        <citation type="journal article" date="2019" name="Ecol. Evol." volume="0" first="0" last="0">
            <title>The draft genome of Actinia tenebrosa reveals insights into toxin evolution.</title>
            <authorList>
                <person name="Surm J.M."/>
                <person name="Stewart Z.K."/>
                <person name="Papanicolaou A."/>
                <person name="Pavasovic A."/>
                <person name="Prentis P.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2019-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="NCBI Genome Project"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EMBL" id="MK291977">
        <property type="protein sequence ID" value="QEQ76386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009701423.1">
        <property type="nucleotide sequence ID" value="NC_044902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5J6CZN0"/>
    <dbReference type="GeneID" id="41854787"/>
    <dbReference type="KEGG" id="aten:41854787"/>
    <dbReference type="CTD" id="4539"/>
    <dbReference type="OrthoDB" id="5976526at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3510:FF:000004">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004320">
        <property type="entry name" value="PRK05715.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004323">
        <property type="entry name" value="PRK05715.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF16">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QEQ76386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="YP_009701423.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10988" checksum="7333CC7221DF2CB4" modified="2019-12-11" version="1">MYYRYMIVAILLLLLGVLGIVLNRGHLIIMLMSIELILLAASFLFLINSIVTDALIEQVFTIMLLTVAAAESSIGLAIMVAYYRIKGTIAIKSLNWLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GX15</accession>
    <name>A0A6P8GX15_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116286429</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031548804.1">
        <property type="nucleotide sequence ID" value="XM_031692944.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8GX15">
        <property type="interactions" value="2506"/>
    </dbReference>
    <dbReference type="GeneID" id="116286429"/>
    <dbReference type="KEGG" id="aten:116286429"/>
    <dbReference type="InParanoid" id="A0A6P8GX15"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="263"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="580"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="761"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031548804.1"/>
        </source>
    </evidence>
    <sequence length="1225" mass="138401" checksum="FA27486B324E11E8" modified="2020-12-02" version="1">MEDLEQLEQLSLVSKICTELDNHLGINDKVLAEFIIMLGEKSSDIDEFKKNLAENGAEFPDSFAANLLRLIEKMKPKAPQSKPGPSSENDDSNLNPAQKERKKLFPGLSIPDKDIKPETTEEDEKVASAALDELEALIPKAKASSLKSSEPDRDSKSYRNRSRSRSRERESRQDRKDRRRSRSRSRSPGRDRRRDRGRDERRRRSRSSERSRDRDDRYGRRSDRDRSRDKDKNRNRDRGRDGKSSRHGTSHTDQAPPATPVVSQIYGGKVTSLMAFGCFVQLEGLRGRHEGLVHVSQLRREGRVANVSDVVHRGMHVKVKVLSMAGNKISLSMKDVDQDTGEDLNPTRVRHNIGGEVTEMSRNPDRXMLLTVHPXXXXXXXKILAGSALVCRXFQWLIIFILAVSXLIAAGVLDKSDYPDFDEETGVLPKEEEGSDEDVEIEMVDEEPAFLRGQTKLSVSMSPVKIVKNPDGSLQRAAMTQSALAKERRELKQAQREAQADSVPKDLGKLWVDPLPDSSEDRPYFAQDVRGISLAANQDLPEWKKASFGGNKASFGKRTSLTILEQRQGLPIYKLKDELVKAIHSNQVLVVIGETGSGKTTQITQYIAEHGFLSSGKLACTQPRRVAAMSVAKRVSEEFGCRLGQEVGYTIRFEDCTSPETKIKYMTDGMLLRECLIDSELNQYSVIMLDEAHERTIYTDVLFGLMKKAVNKRPDLKLIVTSATLDAVKFSTYFFEAPIFTIPGRTFPVEVLYTKEAESDYLDAALITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERCKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKCVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKSGIDALVVTPISQAQGKQRSGRAGRTGPGKCYRLYTERAYRDEMLPTAVPEIQRTNLASTILSLKAMGVNDLIAFDFMDPPPLETMVSAMEQLHSLSALDDEGLLTRLGRRMAEFPLDPPLSKTLIQSAHLGCSDEVLTIVSMLSVQNVFYRPKDKQAMADQKKAKFHQPEGDHLTLLAVYNSWKNNKFSNAWCFENFVQARSLRRAQDIRKQMLGLMDRHKLDVVSCGKNTARVQKSLTSGFFRNAARKDPQEGYRTVVDNQVVYIHPSSALFNRQPEWVIYHELVLTTKEYMREVTTIDPKWLVEFAPSFFKVGDPTKLSKRKRHERLEPLYNRYEEPNAWRISRAFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ13</accession>
    <name>A0A6P8GZ13_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple RNA-binding domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116286996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549464.1">
        <property type="nucleotide sequence ID" value="XM_031693604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286996"/>
    <dbReference type="KEGG" id="aten:116286996"/>
    <dbReference type="InParanoid" id="A0A6P8GZ13"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031549464.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24820" checksum="849B27E91D2FC859" modified="2020-12-02" version="1">MTEVIEEKNKIFVKNIPLGTTKEDIVRLFSNIGGVCDIVLPKPKSGYATTYGFVTFMDEKDVSKAISQYNNFXLCNSEGKRSVLAIVQAYQKVSKLSSKHAASSSLWSLDSHDSEKASVESNESSESKTSEMEQEWAKERITLLQIIDENDKKIKELEKKNSEENEDELLNEKEKEVLEELERLPKKIETLKDEIEVLKLKVKLKELEKEQHQILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ52</accession>
    <name>A0A6P8GZ52_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="2">4.3.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cation transport regulator-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116286419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031548798.1">
        <property type="nucleotide sequence ID" value="XM_031692938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZ52"/>
    <dbReference type="GeneID" id="116286419"/>
    <dbReference type="KEGG" id="aten:116286419"/>
    <dbReference type="InParanoid" id="A0A6P8GZ52"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031548798.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18106" checksum="AD9246DA4B8A5A3F" modified="2020-12-02" version="1">FNIGDIIVISILIISYDCFQPGRVATLLDDKEGVVWGVAYEVEPAEIENVLMYLDIREKDGYKSTYTTLHTIDHSAPTIKVMLYIATPSNNFYLGPAPLPDIAKQIAYSEGPSGKNSEYLLKLSAFMHEVRKQHEDCKDEHLFELEVLVKNNLEGLGNTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H089</accession>
    <name>A0A6P8H089_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transmembrane protein 163-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116286697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM163 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549123.1">
        <property type="nucleotide sequence ID" value="XM_031693263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286697"/>
    <dbReference type="KEGG" id="aten:116286697"/>
    <dbReference type="InParanoid" id="A0A6P8H089"/>
    <dbReference type="OrthoDB" id="5970311at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="137"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031549123.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31724" checksum="07E4F7210BC49108" modified="2020-12-02" version="1">MKDLPQEKQNDGAQESNNSFKKSLNLAYFQDPKXDHRQDKELVSYLYEPNDKEDDVSNQIPKKQREKWSKLAFWLSIFSMFVSILFSLASFLVSYQTDSSSVFASAFDALLGTVSSLAVAWRFRDLLNGGTRGRKRERIATIGIGFGFVATGVATVADSIIHLTDHTHPIKTNQMLIVLTCSLVGFLTLSYGQTCLAKKLNSQSLRAAGADSALAAAMSFGILLSTFVYRSANTLWWLDHFIALFLGVISGGYGLHLFLLTVICNKELFGEQYQEEKPLNEHGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H091</accession>
    <name>A0A6P8H091_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548806.1">
        <property type="nucleotide sequence ID" value="XM_031692946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H091"/>
    <dbReference type="GeneID" id="116286432"/>
    <dbReference type="KEGG" id="aten:116286432"/>
    <dbReference type="InParanoid" id="A0A6P8H091"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031548806.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="9274" checksum="8649D4CFD173EC65" modified="2020-12-02" version="1">MAAQQKKNEVGLFEEDDEFEEFPAEEWTEQDEDQEDIHVWEDNWDDDTVEDDFSNQLRAELEKQGHKVEQQQEPMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2C1</accession>
    <name>A0A6P8H2C1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116287965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031550539.1">
        <property type="nucleotide sequence ID" value="XM_031694679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2C1"/>
    <dbReference type="FunCoup" id="A0A6P8H2C1">
        <property type="interactions" value="1534"/>
    </dbReference>
    <dbReference type="GeneID" id="116287965"/>
    <dbReference type="KEGG" id="aten:116287965"/>
    <dbReference type="InParanoid" id="A0A6P8H2C1"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="10">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031550539.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27980" checksum="4A40416F23B80FC6" modified="2020-12-02" version="1">MMISKVSIFRFHVVSNSLRCIRSLHIGSISCSHVHAIIMGPPGSGKGTVSGRIVRDFGLSHLSSGDLLRSHVQNETEVGKKAKRYIEQGSLVPDEVMVDLVLTELKQRTNSWLLDGFPRTVSQAEELTKNQTIDVVINLDVPFETIIERIKQRWIHFASGRVYNLEFNPPKQPGKDDITGEPLTQREDDKPETVRARLKKYEEETKPLIEYYRILGKVQSFAGTETNVIWPVVKKYLEENYFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3D8</accession>
    <name>A0A6P8H3D8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288245</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550874.1">
        <property type="nucleotide sequence ID" value="XM_031695014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3D8"/>
    <dbReference type="GeneID" id="116288245"/>
    <dbReference type="KEGG" id="aten:116288245"/>
    <dbReference type="InParanoid" id="A0A6P8H3D8"/>
    <dbReference type="OrthoDB" id="10290286at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550874.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32461" checksum="C68B1C62613D3AD1" modified="2020-12-02" version="1">MMLPKISEEKNLKDERIQDFCASMKIENYSESKKKLDVRSIYATENESRQSKEVKPGKNRSVSANISKSSSNSSRDRLGFSRSHLFSAKTSKRTKYKTPKELEETIDLTSIDDAKKLTRRYYQELGICSDGRWSKDIESHLLKFEDADLSFPNLRNKEELFERANKYAIEKQSLLRQKSTFEEDTTLKHTSRPRGKENSARVKTKTHPKLGIQQMTNGFDEIFYSKPVCWGSISNQKSYLISSHFSQRTNRLPSLNTRAVPPKYGSTSWLNSGRTGYTNMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6P5</accession>
    <name>A0A6P8H6P5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Calpain-A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116289320</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552068.1">
        <property type="nucleotide sequence ID" value="XM_031696208.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552069.1">
        <property type="nucleotide sequence ID" value="XM_031696209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6P5"/>
    <dbReference type="GeneID" id="116289320"/>
    <dbReference type="KEGG" id="aten:116289320"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF3">
        <property type="entry name" value="CALPAIN SMALL SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552069.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14857" checksum="15E7704B6B33D8CE" modified="2020-12-02" version="1">MNFFELRNALKGLGYQLSNAALSSVVLRYHNKKGTISFDTFIQIVVRVIVMFDTFQKNSTDSRSPKKATFTLDQVNRDTPNLHYFDRPLWPPLPSRPQFPHPPPRPERIKTLLNQWRRLINLVPIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7K0</accession>
    <name>A0A6P8H7K0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116289579</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552384.1">
        <property type="nucleotide sequence ID" value="XM_031696524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7K0"/>
    <dbReference type="FunCoup" id="A0A6P8H7K0">
        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="GeneID" id="116289579"/>
    <dbReference type="KEGG" id="aten:116289579"/>
    <dbReference type="InParanoid" id="A0A6P8H7K0"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016939">
        <property type="term" value="C:kinesin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01371">
        <property type="entry name" value="KISc_KIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000028">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="9"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="587"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552384.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="77071" checksum="0369C25CCFD6C676" modified="2020-12-02" version="1">MPEEKGGDNVRVVVRCRPLNEKEKGSGCSVCVRVNEANGTITVENPSARSAGEPPKRYTFDRVFAPEVKQVDVYTDAARAIIESVLEGYNGTIFAYGQTGTGKTFTMEGIRSIPEMRGIIPNSFAHIFGHIAKVDGDVRFLVRVSYLEIYNENVRDLLGKDEHASLEVKERPDVGVYVKDLSSYVMNNADDLDKTMTLGNKNRSVGATNMNERSSRSHAIFSITVECSEKGPDGQHHVRMGKLHLVDLAGSERQTKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMIANVGPADYNFDETISTLRYANRAKNIKNQARINEDPKDAMLREFQKELERLRAQLQDEEGGATDESSSEEEVEENGVIVKRKKNKRKTASHAIPPEKIAEMQAKIEAEKAALQAKKDMAEEERNAAAKELEKREKDIFQAQEEHKKLQDKLKAIESKIIVGGVNLLEKAKEQEHLLEASAKELAERHARERELQKLIEEKEMADQQEEHQRETEGLLENIRELRRELQCQAMIIDSFIPPEFQELLDHNKCWNEELGEWQLRFIAYTGNNMRRATPSPDPKDKHKEMNETDISDVYLSYSSIGYPTSGGEPSRPKSSRPKTASRPKTASRPKTGKRKKNGDSSLSENKDEGDSEVFPQSRRLLSPKKHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7U3</accession>
    <name>A0A6P8H7U3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apoptotic chromatin condensation inducer in the nucleus-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552499.1">
        <property type="nucleotide sequence ID" value="XM_031696639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7U3"/>
    <dbReference type="FunCoup" id="A0A6P8H7U3">
        <property type="interactions" value="2593"/>
    </dbReference>
    <dbReference type="GeneID" id="116289686"/>
    <dbReference type="KEGG" id="aten:116289686"/>
    <dbReference type="InParanoid" id="A0A6P8H7U3"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552499.1"/>
        </source>
    </evidence>
    <sequence length="1007" mass="114432" checksum="68099D1B25F98037" modified="2020-12-02" version="1">MAEIGDEFMIGGRKLAQLKNDELKQELEKRGLKKSGNKAVLVERLSEYLFKELYEKPQQHPVPQTSVQQTIQQQHTAFQEQPLTVQQTIQSQTIQQQSPSYQNQPFQQFPGQHQGVPYQQLGQPQGAQILSPQRTQQPVAFFQQSPQREQQQGFQSPPHKEPAFLPHSPQNQPVFHPQVPSQTSALHHSNINQQQQMQHQQNVLQDQFYHQVNQQPPQQRHFQQGQQDPILQFMEQYQHQQQQPRQVQQRVFDPQQLNQNMVQQQGVPPQVAQEMTKQEAVPPFEAQGLQQESAMPEGTESNSFREQSPGGESSSSSTIIEEDEQSFPPQPPKQEQAPMEEEPDNSESTSSSQPSPAEVEKSEEPSPALQYTKEDESSSGGTSPAEVEKSEEPSPALHDTKEDESSSGGTSPTDRSQEPSPAPELSALNQEAQEEQQETVEVKENLDKEKSEANSDAENMEQSPKEDDKPEEIGGKRLTKVEEMVDENSKEAGQAEGKDGQSLRESSQADSEEKTDQSPSGSGGLEEGEVDASSNEDSKEIQEESVVSSSEPGFVIEPTEEEKAVAEEPKPVEKKPRTPIITKKRRISIPSSGSQPGTPPAEGTRKRRWGSASKTSKPISTESLKDLIPGVQVHSTPALEAVMDFGNEDQDDGDEREAGEVVDDDDDEMNKENREKDSDEQETEKIEPEPKKRKERIVKVEEGRKKIKINRQSLDPEANKKEVEGAQPSLSNTDHKFPAIPILSQSPLPAEHSPSPARNAESVNVHVKNLVRPFTERQLKELLGKTGTLKEGGFWIDKIKSHCYAIYTDVEGAVATRAALHGVKWPQTSPKILSVEFEDDEQMATDTNGVLGKKRKEVEQPVKEDTKVEKEPVKEEEVEEKPVEEDNSPADLLDNLFRKTKTTPCLYWLPLTTEQILKRDYEREEKRKRREEERKKDDEDREKRQKEREEQRERERERERGQQTRNRVRDRSPDRDRSRENRGGRMRSKSPDRRRFSRSRSRSNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8B1</accession>
    <name>A0A6P8H8B1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">5-hydroxytryptamine receptor 1E-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116286563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548982.1">
        <property type="nucleotide sequence ID" value="XM_031693122.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H8B1">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="GeneID" id="116286563"/>
    <dbReference type="KEGG" id="aten:116286563"/>
    <dbReference type="InParanoid" id="A0A6P8H8B1"/>
    <dbReference type="OrthoDB" id="5960104at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031548982.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44458" checksum="A254B745BCA434FD" modified="2020-12-02" version="1">MDDCQEKHNKIDQFDPDFIIPLIVLHSLSSICATLLNALVILTIWKTPSLRTPSRIFLCCLAVSDFFMGFIAQPLFVVYCIAALRKWTDIFCAIWVVNLRVAYCLGGLSLGXLTFISIDRCLAIKTKMSYKSLVTLKRVLWLVICGWVLCIVSISLAIQYFPFRTCLLVGSVFIVVGLLIITVSYSLSFHALKKLSLKVSCPPSSSTSKNKLALMNQSASLNPLASIHQSTSRKKSASVXESASTDQSQQENKPPTXNQSXLVIQSASXNXXPSNDTPPSLDQSPSGFQDNPXASXXQXTQSTSSRLPASTDFNAFKYKRSLITMLMILALTILSYLPLICHTFINALITLNNAIVFSQFSQFIVALNSTLNPLLYLWRMKDLRRATNTTLRPIISKVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H991</accession>
    <name>A0A6P8H991_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 3A2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116289344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552096.1">
        <property type="nucleotide sequence ID" value="XM_031696236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H991"/>
    <dbReference type="GeneID" id="116289344"/>
    <dbReference type="KEGG" id="aten:116289344"/>
    <dbReference type="InParanoid" id="A0A6P8H991"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031552096.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58373" checksum="B1FD8B5D817CB0C8" modified="2020-12-02" version="1">MAFFNTLLVFLTANWFAISLTVCISFILYIWGIAPFRRSRVLALVGDLPGPAPLPFLGNLLDLIKLKGQTHLYIDEYYKKYGRLFTMFLFTKRPSLFIGDPEMTKEILVKEFQSFHDRPLFFEIPKPFDVMMSIATGETWHRIRTTISPTFSAHKMKLMIPLMNKSCDLLEKKLDQVAGTGETIDIYKYHQGLTMEGILSTFFGIESNAQNDYNDPAFKAARESLDPGPFRRFITAFVGILPFGSYFVRYFPSFFIGQFQNLVHLTEKIIEARKKEGDSARKDVLDLMLSATQPDVAEQKTLSEYEVIAQSMIFLFAGYETTSITLALTCHHLATNQDFQEKLQKEIDDVWRDEDQPPSYEVVQSLPYLDMVISETLRLYPPGFFLARECTKDCVIKGLHIKKGTPVITPAYSIHRDPEFYPDPEKFDPERFSAEAKASRDPYAYLPFGQGPRNCIGMRFAQMEMKLALVRILKRFTLVVAPETKIPPVIVAKPSILGCDGVKLRVQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9L1</accession>
    <name>A0A6P8H9L1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116286721</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116286721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549160.1">
        <property type="nucleotide sequence ID" value="XM_031693300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286721"/>
    <dbReference type="KEGG" id="aten:116286721"/>
    <dbReference type="InParanoid" id="A0A6P8H9L1"/>
    <dbReference type="OrthoDB" id="10409160at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031549160.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29989" checksum="D70BD246E030C7F2" modified="2020-12-02" version="1">MPVSWAQHKLNQYRGDRGLTSQQSKGLYQLTNNLTPVGTPICKQCRMQLKSEXDLLQYRSLPENEEDPVIQTSDDEQNVEEPDIGSCECATKNSDAGSELLDDLQYALEKLNLEEDPAVIFSDSTESSNGSIDLSKQKLQKLNEFLRVCKGNAECGSIGQPNKPWENMSQRSKNVYINRATEAIVSVLDVLTPGDANNLWEAVQSSHSVDKVLGVLQPTERQYLEALAEAYQNAGSWDTKRXILAIMSDLVTFCQIPKFIPGLTKYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9Z5</accession>
    <name>A0A6P8H9Z5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553264.1">
        <property type="nucleotide sequence ID" value="XM_031697404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9Z5"/>
    <dbReference type="GeneID" id="116290384"/>
    <dbReference type="KEGG" id="aten:116290384"/>
    <dbReference type="InParanoid" id="A0A6P8H9Z5"/>
    <dbReference type="OrthoDB" id="5969695at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553264.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="40781" checksum="88D0CF4AEA77151F" modified="2020-12-02" version="1">MSSVKQVRFTGVNGETTQNHEDTSPAVNPKRKTVDLSSLLREPKTENSTERQPATEKRKKKKRKSEFQKLKAEKSKLMKELKKTETSIKEDSERKRNAEYRAFENRQRLARSTSEIHSKVKQLENKISTKEKLRRGKIQKSFKTKIKTTTIKAGKQHGRLIDLTSKLDYLKLDEEQLRHEIYREKSMPSLSAPSTSSCHSNAYEIIPPENEEMETWVKLSNNSKREKERETKDKVHTASDTSTSSPELELYRIGSSLSCETELSTLEEKEAKADKLARKYDFTRELRNTIHQHMISRSYSYSYTNIIPPYKHKRHKPVKTKQSYNRAIYEDKLNVQEFAKKQKKLPVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAE6</accession>
    <name>A0A6P8HAE6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116289364</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116289364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552123.1">
        <property type="nucleotide sequence ID" value="XM_031696263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HAE6"/>
    <dbReference type="GeneID" id="116289364"/>
    <dbReference type="KEGG" id="aten:116289364"/>
    <dbReference type="InParanoid" id="A0A6P8HAE6"/>
    <dbReference type="OrthoDB" id="5950059at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031552123.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23127" checksum="7AA65D0F8071343C" modified="2020-12-02" version="1">MRKANSKSLMLVTACSPNPCQNGADCIADDRGHKYICNCTKGFTGINCKRAGCILFDFEDGLTGWTRTGTAFNNQPTYGDNSLVRNSSQTANLKGDWYIGTYENRPSPSHPAGAKQGNRPTGTMTSHKFVIQAPSLTFLIGGGSNSSYEWVELQIGVALVAKASSLDDTNSMKPKTFDVTRYLGQVAQLRIVDVGTKEWGYINVDHFHICTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB82</accession>
    <name>A0A6P8HB82_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium/myo-inositol cotransporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Sodium/myo-inositol transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 5 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116290037</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Interacts with KCNQ2 (via the pore module). Interacts with KCNQ1; this interaction is direct. Forms coregulatory complexes with ion channels KCNQ2-KCNQ3 and KCNQ1-KCNE2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552871.1">
        <property type="nucleotide sequence ID" value="XM_031697011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HB82"/>
    <dbReference type="FunCoup" id="A0A6P8HB82">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="GeneID" id="116290037"/>
    <dbReference type="KEGG" id="aten:116290037"/>
    <dbReference type="InParanoid" id="A0A6P8HB82"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000013">
        <property type="entry name" value="sodium/myo-inositol cotransporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF150">
        <property type="entry name" value="SODIUM_MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031552871.1"/>
        </source>
    </evidence>
    <sequence length="670" mass="74308" checksum="3DAFC7146B531585" modified="2020-12-02" version="1">MMASSPPGLQGWDIVIVVVFFSVVVAIGIYSMFRTNRGTISGYFLAGRYMTWLPVGASIFASNIGSEHFIGLAGSGAAAGIGVGAFEVNAMIMIQILGWVFAPVYIASGVCTLPEYIRRRFGGVRIRVWLSVFSLLLYIFTKISVNLFSGALFIRLALGWNLYLAILLMLFISCLCTITGGLAAVIYTDTLCTTLMTVGSLIVAIMGFSKVGGYNALQEKYMVAVSNDTLFSNSTCGRPRPDSFLMLRDPINSDIPWPGFIIGETIISIWYWCADQVIVQRVVAAKSLSHTQGGCLLAGYLKILPLFTLLMPGMISRVLSPDRVACSVPEKCMEICGSEVGCTNIAYPELVLKLMPTGLRGLMMAVMMAALMSDLTSIFNSASTLFTIDVYSLIRKKASVRELMIVGRIMVAVMTGISILWIPVIQNVQGGQLFMYIQAVTAYLSPPIAAIYVVALFWKRATETGVFWGMITGFAVGVIRMTLDFVFQEPRCGEPDNRPAITRHVHFMYFAIIAFLITTIAIVIISYLTKPSADRKFSRLTWWNRYDESSTNDHLETDRDNEIAMEHLQFNVSRDNSDAESEEIADKNVDIPLDKNDTDEPHPSRIKRFYSWFCGYEAGSEEAKKAAMQQQQRLAIICSLKQNSKAKIFLNANFLFISVLCVFMMVYFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBL9</accession>
    <name>A0A6P8HBL9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PI-actitoxin-Aeq3a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116287538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nematocyst</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550082.1">
        <property type="nucleotide sequence ID" value="XM_031694222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBL9"/>
    <dbReference type="GeneID" id="116287538"/>
    <dbReference type="KEGG" id="aten:116287538"/>
    <dbReference type="InParanoid" id="A0A6P8HBL9"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042151">
        <property type="term" value="C:nematocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008200">
        <property type="term" value="F:ion channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22603">
        <property type="entry name" value="Kunitz_SmCI_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000021">
        <property type="entry name" value="Serine protease inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF328">
        <property type="entry name" value="TISSUE FACTOR PATHWAY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0166">Nematocyst</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027655190" evidence="9">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031550082.1"/>
        </source>
    </evidence>
    <sequence length="78" mass="8927" checksum="BB4F26320DA787FD" modified="2020-12-02" version="1">MAKQLIFVLFLAMAVGMTMARPEFCLLPAETGRCMGYFPRYYYDESIGTCRQFIFGGCQGNENNFETMKECVRKCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC32</accession>
    <name>A0A6P8HC32_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase subunit 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553191.1">
        <property type="nucleotide sequence ID" value="XM_031697331.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HC32">
        <property type="interactions" value="1367"/>
    </dbReference>
    <dbReference type="GeneID" id="116290328"/>
    <dbReference type="KEGG" id="aten:116290328"/>
    <dbReference type="InParanoid" id="A0A6P8HC32"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553191.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23819" checksum="E8D886ACC57B5E6D" modified="2020-12-02" version="1">MAQITTRFLRGRISALSRQVXRPFSXGSANNSYKYVVEEAQDTPMDMKTSTDRNATTLFFSELLRGLGITLSKMFQEPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDRWETEIAANLQADFLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC65</accession>
    <name>A0A6P8HC65_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031550100.1">
        <property type="nucleotide sequence ID" value="XM_031694240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HC65"/>
    <dbReference type="FunCoup" id="A0A6P8HC65">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="GeneID" id="116287557"/>
    <dbReference type="KEGG" id="aten:116287557"/>
    <dbReference type="InParanoid" id="A0A6P8HC65"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="82"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031550100.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="34343" checksum="9505379845C68893" modified="2020-12-02" version="1">MGVLSALKGINESFHILSQITKSTSNRVLTSIIFFKHVVRGAHYAPPRPIPSSIALPVYAKTGEVPNPPREVEIKTKEQIDAVRSACQIARKVAGHAKDFIKVGVTTEDLDSVLHHSIIDYGAYPSPLNYKGFPKSVCTSVNNVAVHGIPDSYSLKDGDIISVDISVYYGGVHGDLCETFLVGNVDDAGRKLVDISRKCLDSAICQCGPGVRFSTIGNTISSLAKQHGFSVSPYCYGHGIGSVFHALPDICHVANNYPGRMAPGMTFTIEPVIHEGSSGIQVLDDGWTMIATDGKRASQFEETILITDSGIEILTQEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCT4</accession>
    <name>A0A6P8HCT4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116291241 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554244.1">
        <property type="nucleotide sequence ID" value="XM_031698384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCT4"/>
    <dbReference type="GeneID" id="116291241"/>
    <dbReference type="KEGG" id="aten:116291241"/>
    <dbReference type="InParanoid" id="A0A6P8HCT4"/>
    <dbReference type="OrthoDB" id="5975444at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000003">
        <property type="entry name" value="Neuropilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027871974" evidence="6">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="146"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="276"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554244.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43581" checksum="92F59901CF0118F3" modified="2020-12-02" version="1">MHCFNIAIVLPILVYLQFIDIKGALSAVDVKQNECYKSKALLDCPLYKDPSMVLKWRYQELLTGRWSKIAIVKSGKARVFPVNSNLDGRFILHSNGSLEIRSLHHDDETLYQCIVMQRGDREAHLIELNVACGHTTVTKREVCIEEDVVLDCDAKHRTNPRKLKQVTWKKESDGKQGSSFSKVAALYDDVTTDANDGFSIHSNGALLVRKGREEGNMTYKCDVSRTDGNKDETHLVHVKSIKCRNETQKPVKRNIGSVSMTTEGASVIITQKTIVCGGVLNNSVGTFQSPNFPSAYPANSHCKWTISLPQDYAAINITLDHLNLEPEKRCRYDYLAVYDRLDNQVGCRHCGLYGKTIIFQVRGRTAVVVFKSDDSVQKTGFKVSYRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDB0</accession>
    <name>A0A6P8HDB0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Akirin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116291344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554379.1">
        <property type="nucleotide sequence ID" value="XM_031698519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDB0"/>
    <dbReference type="FunCoup" id="A0A6P8HDB0">
        <property type="interactions" value="3107"/>
    </dbReference>
    <dbReference type="GeneID" id="116291344"/>
    <dbReference type="KEGG" id="aten:116291344"/>
    <dbReference type="InParanoid" id="A0A6P8HDB0"/>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22240">
        <property type="entry name" value="akirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF6">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554379.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19540" checksum="173A33E038E55A3F" modified="2020-12-02" version="1">MACATLKRSFEFDPLLSPQHQPSPKRRRCVPMSTSTSCQSPSQSSKESPFTDVTPRITQEQLSTNIHLEWKRLQRRKHLKAPTCNSVEAMNTVLSSPGSSPTRKDQPLFTLKQVSLICERLLKERDTQLKEQYDKVLNTKLSEQYDAFVKFNYDQVQRRFEKTAPTYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDP0</accession>
    <name>A0A6P8HDP0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tudor domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116291509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554539.1">
        <property type="nucleotide sequence ID" value="XM_031698679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDP0"/>
    <dbReference type="GeneID" id="116291509"/>
    <dbReference type="KEGG" id="aten:116291509"/>
    <dbReference type="InParanoid" id="A0A6P8HDP0"/>
    <dbReference type="OrthoDB" id="434939at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF24">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="80"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031554539.1"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117783" checksum="B21C92BF339F7187" modified="2020-12-02" version="1">MEGNLKENGWFLSSEGIAECKKACTKENPTTSECLKAATNLDLKLYGTKFLPEDLHKGKIEFIKGPGVLQIQKLRNVSAPKSNEESTHAPRLLKFYLTDGSMNCQGIEFSTISDISLSTPPGTKICLIGNVPVENGVLLLDNNNIKVLGGEVESLVSKWKLNKSLAKHSRTTANGEDGPPPFVPFNQAKPQESKGNSKGTSVSNGHGMENELNIKQPDRNKPETQHDMYNNNKRGKDRNQEKDGDRHTDTGSRRDDRGDQRGRRGDSWGGGPRGESFRGDRRYNQDKSYGKFSSDSRSSQKDNRGNREYKGGNRNYENSQSGDSRIGDRNNPRRTDHNRTDKAEKPSQSGRTVDNTAHQKTSNMASGNARENGTGESQSRDSKDRQSSDGGSRHSFEGQGNRLGHEGLGRGGQGGRGSSRGGRGGRKDGFGRGRSNSMEQDDSDDYRSRQPSDAGTLWDFVKLTIKTPPKSSTPPPAPKESNNSDTKPDEPKQPSASDSTQEAQLAQENTPNENAESQQTTKSQQQQNDRSENTKQVKPEPPTSQSGKEQKQLTKSNDRSKDGEKHGRNTEQLSTQFRDNRQRQYQQRQQQSSGQGRGRGPRGRHEDGRSYNQSLPPRLQKKQQQQYHQQYHHDRDRKSSIERDSHREKTSSPGSGSSGDGRSSQSPSVESGHSSQSKSSDDIHQRQQQQPRRQKGSQKQQQQSEDYNTSAEQKQSTGPKQGQYDSQMTPSGYISSQPSVQHTHYHVDQQQMYEQQDFNYQQTPPPPPPPPQQYPVYQMPTQMGPPQAVMVTQPITPPSQPHLQTPIPSNQMRWKKGEQCLALRRDRQYYSAKIEHIHPDGQQCMVSFQDFHGGCEMIPTTSLRPFPIITWTDSNAQSLPVATTMTAVPVYAQPAQVAMVPRPQVMVQMQAQPPFPMGPKGHIPNQGPMTPQGLPQPPPGMQWQPAQMNYQDLRQPYPQIIHYDPMGQANNPAARPTYYPVPPGGAMQFVRGVKELHGQELYPHTGNMVEVTADGNKAQPITTVYYNVKSKKTNTRPTQSYYMPPRQQTYGDPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDZ6</accession>
    <name>A0A6P8HDZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291603</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554644.1">
        <property type="nucleotide sequence ID" value="XM_031698784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDZ6"/>
    <dbReference type="GeneID" id="116291603"/>
    <dbReference type="KEGG" id="aten:116291603"/>
    <dbReference type="InParanoid" id="A0A6P8HDZ6"/>
    <dbReference type="OrthoDB" id="5988715at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027684844" evidence="1">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554644.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20229" checksum="F39656F20E5EB572" modified="2020-12-02" version="1">MSVLNVVIFCVLVAWNYADAHVQESITLRVFDRSFNPGDVSVYQRLLDANLEGRGFNREIVTKTVTEKDNSTMHQVVFLFHKTVACRRAGEVERKINEYVEGLLSGELADRLAIELEKRKINQLPTCKVGIEVHFRVDPRTLFRGRRARRGVDQPRERKQDNHVCIGVCIHIVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEC7</accession>
    <name>A0A6P8HEC7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPRY domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554784.1">
        <property type="nucleotide sequence ID" value="XM_031698924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEC7"/>
    <dbReference type="FunCoup" id="A0A6P8HEC7">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="GeneID" id="116291714"/>
    <dbReference type="KEGG" id="aten:116291714"/>
    <dbReference type="InParanoid" id="A0A6P8HEC7"/>
    <dbReference type="OrthoDB" id="40953at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12880">
        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554784.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21575" checksum="A40951B536A3AFA2" modified="2020-12-02" version="1">MDVCGLGILCCLRRYQKPRNDKDVNEIQVQLDTTQMGHEVVIVKSGRRICGSGAALANAPLLQNKCYFEAKIQSGGVWGIGIATKKCDLNKIPLGNSPDSWVLRSDGTVAHNSIIHHKLTTIPEEGDIIACTFDHVEANFYHNGKHLHSPLTGFRETVYPIIYVDDGTIVDVNFKDFVFEPPSGFTGIMFEKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEJ2</accession>
    <name>A0A6P8HEJ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VPS35 endosomal protein sorting factor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554146.1">
        <property type="nucleotide sequence ID" value="XM_031698286.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HEJ2">
        <property type="interactions" value="2407"/>
    </dbReference>
    <dbReference type="GeneID" id="116291162"/>
    <dbReference type="KEGG" id="aten:116291162"/>
    <dbReference type="InParanoid" id="A0A6P8HEJ2"/>
    <dbReference type="OrthoDB" id="1734063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554146.1"/>
        </source>
    </evidence>
    <sequence length="973" mass="110538" checksum="8F39D6E2C5B83C8E" modified="2020-12-02" version="1">MAAQEWVARQRRYDKEKTAFPAEEVKEHPLKVGQIITVDKGQKTPGASKQEDAPKPVDPLSITSQGDAFDGLDPLSMFMAEQTASKKTPTSGPMRERVASLKGEESGMGEFDHDTFEPWSSKRSSILTKYTTSEKLSITTSFLSSSDKDKIVIKQQTTVADKVKHRLEQLDDFEEGSVKEMLNLSQQDYVKRIEELNQALISAWESDQRVKALKIAIQCAKLLADVSVIQFYPSKFVLVTDILDTFGKLVYERLFRKSSVFNPGSNVPVMLPENFTPDQVPDSAKETCRNWFFKIASIRELIPRFYVETAILKSYNFLTQGEFSQALVRLTKMIRGIGDPLVAAYARCYICRVGILVAPNVKEHLIENLYSFITCYQQLQSDTVQNILAVQRLEMQQYLHLYPPALDWILQCVAHKSSESILTDILNRCKKECNSALLLNSVILAFKPQFISERALQFTELIRNCEEAGFPKHHLYRSLGLNLIICDPPEDQKLAILSEVWKVVMKLKNPEEYISCAEIWVEYPCKHFTKREVNTMLGDIMKHMTPDRAFEHFYPQLLTVISKLLSHMHDFSALVSMDKFLPFLDMFQKESVKVDAYKMIMEAFVKYQLEPTNDPVVQNALMFVCKTLHDSVNALTLEDERRVIGNLISGYLRKADFGRDFEKQLDFYVDARASFSNLDPVLVMLVQRVNLLALQTRAIVNGNHSRKTASFVRACAAYSFITIPSIMDFFTRLQLYLFSGXVAMANQALSQADAFFKAAISLIPEVPKTIEVDHKTKASEPYLLNFLNQFLSTLLVVPDSPDQGVLYLARGLLNVIQEYTWELNSDAKMTLYLNAVGLLSALCQESYLYHIDKVDSNDKLYGCDVKFVTEVCKIVSTLIQTVFDHLKTLTSHEDLKRQAAIALGFFNRMICHADIGNPDLAALAINLWNLAQKHGFGGTKYMVRTLDYVQSKGNAGFSEFTELAKRMHLQSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEZ5</accession>
    <name>A0A6P8HEZ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Uncharacterized protein LOC116291298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC116291298</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554320.1">
        <property type="nucleotide sequence ID" value="XM_031698460.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554321.1">
        <property type="nucleotide sequence ID" value="XM_031698461.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554323.1">
        <property type="nucleotide sequence ID" value="XM_031698463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEZ5"/>
    <dbReference type="GeneID" id="116291298"/>
    <dbReference type="KEGG" id="aten:116291298"/>
    <dbReference type="OrthoDB" id="10268014at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554323.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54943" checksum="8548B220D0FA2205" modified="2020-12-02" version="1">MTTNTQQPAKPSKLIKPNSFEPNNHWVHKGYEKPIDPVAKYFLELDGSSIVRRYCMLHPMVSKEKLETLLAYQPRYFLWAGADLMKVASKDGEKKMVLIENNSCPSGQKYMPLVDKEQKHGGYRTFLERTFKTTLNSRRLVQGELAVLYDKNPIETTGYAHAMADLFNEEVHFVSAYIDETNPAFEFRDGVLHVFGEDQTWHPIRAAFRYVTQRPWNRLPISSKTLIVNPSIVCLAGGRNKLLASKAYTSFNKELLDTGLAINTPLTICDVQRRDIPNWVAKFGGQAVIKIPYSNAGQGVYIIKNEEQLQDFLNENHPYELYIVQELIGLREEGHEGVQRYTHIGTLPSEKGCVYVSDVRMMVSSSPTGLRPVGMYSRRAGRPIVDGFGEVSDHAEAFMTNLSFKNPDGTWNSDVDRMIRHDCHNFLQLGLGLDDLIEAYVQTVLSTIAIDKMAQALCDENGQFSKEVFQSLNDDSLLLSEIMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF91</accession>
    <name>A0A6P8HF91_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288577</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551240.1">
        <property type="nucleotide sequence ID" value="XM_031695380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HF91"/>
    <dbReference type="GeneID" id="116288577"/>
    <dbReference type="KEGG" id="aten:116288577"/>
    <dbReference type="InParanoid" id="A0A6P8HF91"/>
    <dbReference type="OrthoDB" id="5990356at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551240.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49157" checksum="F31C35DF5C3C281D" modified="2020-12-02" version="1">MSSNTGNISDQDVENCPPSQQLSCTNNTNGPSISNPPSVKRNSYMKRGGRRRRWWYFNRGLQPISELAEIKDDAVKCENHDVLPTIMDDSCVINNYSHTNTTIISSDSTQNKESYSACLKLIEKFQEVVMDSAVRVIQAAFKRFRERRRFLRIKRAVMVIQRNLRKWLETKHPCIRPTDFERQSSDGSKSDEYRETIENESEGCVTEEEDKQLNCNKSEKCQENNNTNGNESSVKNSSVYKHQENTCTSDAGNVNAGVELNKAIINVEPNCLSQREEETIESSTAQVKKLVTMSTEHEHEIVRDVKSLLEELLVKVISNIPDSDGKQNQSAKSKDSMTPVNTTDIILCSSIRLTQNDETQENLLDKANINVEQDDLNCENENQSKTTAGDDMGDCVEHMPNVTKILPDSLKEICQKFLDVSETSNPHNMEDNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHN4</accession>
    <name>A0A6P8HHN4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein 121B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116292696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555909.1">
        <property type="nucleotide sequence ID" value="XM_031700049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHN4"/>
    <dbReference type="FunCoup" id="A0A6P8HHN4">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="GeneID" id="116292696"/>
    <dbReference type="KEGG" id="aten:116292696"/>
    <dbReference type="InParanoid" id="A0A6P8HHN4"/>
    <dbReference type="OrthoDB" id="5964337at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026624">
        <property type="entry name" value="CECR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47399:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 121B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555909.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38678" checksum="0B385BF8F67BB1A7" modified="2020-12-02" version="1">MGKNTAIWRRHVARILGVLLLVFQGAIIDYYLIQGESSRWFAWLLTDGVVLATWIAAMLISYRRLSSRKQRYSLDQGVGFFNDELAFAYIAWLVYALHLVPQVATLFRTKASKLDEKTMVFGPNMLKMCLCITPALFLFLLFAHHDSKPRTSRKFYLEKLSGAVTLDLFDSVEMLEYLFEKDAVPDSVNIAILIFSCINFFLPVFALYELKHNKFHANGQVSPLSFKIFYICSFLFFVNVPFLVIRLILWHSYHLDISVLLAKNALAIVLGVIEIAEFCGDERPKKCLSCSNTFAKSSFKSHLEVCANEATGELELMRVNEQSPSNDGPTITVKTGDPNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HII8</accession>
    <name>A0A6P8HII8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116289656</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552462.1">
        <property type="nucleotide sequence ID" value="XM_031696602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HII8"/>
    <dbReference type="FunCoup" id="A0A6P8HII8">
        <property type="interactions" value="2130"/>
    </dbReference>
    <dbReference type="GeneID" id="116289656"/>
    <dbReference type="KEGG" id="aten:116289656"/>
    <dbReference type="InParanoid" id="A0A6P8HII8"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000064">
        <property type="entry name" value="Septin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008113">
        <property type="entry name" value="Septin2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01740">
        <property type="entry name" value="SEPTIN2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="18">
        <location>
            <begin position="37"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031552462.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41468" checksum="F3E796650CB40D03" modified="2020-12-02" version="1">MTSFESLSALKEQLLNMADYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLIDSLFLTDLYSDRILPKAEERIKKTVKIETSTVEIEERGVKLRLTVVDTPGYGDGMDNKDCFKPISDYINLQFENYLHDESGLNRRHIVDTRVHCCFYFISPTGHGLKPLDIQFMKELHEKVNIVPVIGKTDTLTPSELSAMKTRIRNEIDDYGIKTYILPDCESDEEEDFIEQTKQLKASMPFAVVGSNTLIDVCGKKARGRLYPWGVVEVENPAHCDFSKLRTMLITHMQDLKEVTQDVHYENFRAAALGETTPATPRTSKSLNRVKEQAAKEVMEKERALKEKEEELRRMQDMIAKMQAQMKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJH8</accession>
    <name>A0A6P8HJH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290010</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031552837.1">
        <property type="nucleotide sequence ID" value="XM_031696977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJH8"/>
    <dbReference type="GeneID" id="116290010"/>
    <dbReference type="KEGG" id="aten:116290010"/>
    <dbReference type="InParanoid" id="A0A6P8HJH8"/>
    <dbReference type="OrthoDB" id="5991672at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552837.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26148" checksum="5D8C2E2EFE16E963" modified="2020-12-02" version="1">MSALFVGVNSVLKGFHATQAVLEVGKEYILTKMNSVHDENAFFVLSKDGTIQASMPRELARLIAPFKVRGQVLCIVCSPTAGLRESNKGLFEVGGGIVMPCIYCIQCKSENVARTLAGIIPNSHLRKLKEQNDTIKDQEINVGSRSSCSAQDSEDCKDNENHDDSEESDSYRYQEQDDPGQETFYAEYQQAQEPIDFDEEDNYDYDLVPSSVSPPGITDDWDVYFQGLPQLNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL44</accession>
    <name>A0A6P8HL44_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane prolyl 4-hydroxylase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031555648.1">
        <property type="nucleotide sequence ID" value="XM_031699788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HL44"/>
    <dbReference type="GeneID" id="116292469"/>
    <dbReference type="KEGG" id="aten:116292469"/>
    <dbReference type="InParanoid" id="A0A6P8HL44"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028324804" evidence="8">
        <location>
            <begin position="26"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="243"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031555648.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48205" checksum="07FC65A7D0FD18A5" modified="2020-12-02" version="1">MAQRQHFWRCFLFSCSFMILSNTASKSTSSLTEKSTKLMVLDGPCVIRRTRLPRLDGIKVGHVQPIQLTSNTDPHLVKTISLSPPIFEIPDFLSEEECDKLIKLANSHMMQTSDIINPGATLSKLDYDTTFSQWDRNGDKLIDKHEIFAQLLYLRDMHFTDKDIDKMLQTLKIGQIKKGFIHPKEFQGKKLMGYIDQVRLKDPKVIGRHSNETWLDMWEDDILRDLNFRKAALTGLPLEVIEGSETPVVIKYGKGGHYHCHYDSHSPVVIQPCCHRSSQDGCRVCRYITIMYFLSDVETGGQTAFPIANNITFNHKKWHQQLQNFSNLSAYCSKANIIVTPKKGKAVMWYNHVVDKSTGWLAGLDQMSYHGGCDVIRGEKWIMNNWINIIGQNFGNIRTWNDTYTKLHIYKDHLGKYGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HME5</accession>
    <name>A0A6P8HME5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RYamide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116290850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553820.1">
        <property type="nucleotide sequence ID" value="XM_031697960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HME5"/>
    <dbReference type="GeneID" id="116290850"/>
    <dbReference type="KEGG" id="aten:116290850"/>
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    <dbReference type="OrthoDB" id="5951670at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031553820.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42498" checksum="3DC08F60FA2E2D59" modified="2020-12-02" version="1">MQHTNSFQWNTTSLKNNTMQPQSGPTLLEWNIRVSIDVLISITSFVGNSLVLFVIYTRKKYQRTPFEILVANLSITDLLSISIYLTFSYFLKTTSNFTCKFGTSFYTCLLMLSMYLMTAIAMFRCRSILYPFKRRPSIKFTYCVTAGLWIFANAFISPVYVVTIWDRNTGSCIEIWPSQIYNRVYTISLFVVQYVIPLTIITASYIKIVSYLKQHKPPQIDCNKNHSLMLKRRRDIEVIKTSATIVTLYTVLTLPGQIAWISGVVFQNYEISMLILKFSTHLQLLHNCCNPFVYGTISREFRSQLTKAACDIINWIFRRNSVRTVAVHREQGYMNKSLEELEINDVILTSVQSKRSKQDDNPTHKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HML3</accession>
    <name>A0A6P8HML3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553885.1">
        <property type="nucleotide sequence ID" value="XM_031698025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HML3"/>
    <dbReference type="GeneID" id="116290908"/>
    <dbReference type="KEGG" id="aten:116290908"/>
    <dbReference type="InParanoid" id="A0A6P8HML3"/>
    <dbReference type="OrthoDB" id="5997459at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553885.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16429" checksum="8A326A938A049903" modified="2020-12-02" version="1">MAKSPDFLQQSFVKKTKENDLQDIGEDNLSALELYLHDLGHERRPESRKNVILDSLSNNIQPSTSYTPKNDGRKKQEKEQNHPRTKKSFQRCCSSFMIGIVIVVSLASLFINVLMIKGTIVPSGCQRIENRKAIGTISNIVLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN99</accession>
    <name>A0A6P8HN99_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Replication protein A 14 kDa subunit-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556473.1">
        <property type="nucleotide sequence ID" value="XM_031700613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HN99"/>
    <dbReference type="FunCoup" id="A0A6P8HN99">
        <property type="interactions" value="786"/>
    </dbReference>
    <dbReference type="GeneID" id="116293212"/>
    <dbReference type="KEGG" id="aten:116293212"/>
    <dbReference type="InParanoid" id="A0A6P8HN99"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000395">
        <property type="entry name" value="Replication protein A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556473.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12577" checksum="DF7D281D89B47CC2" modified="2020-12-02" version="1">MEAPRVNASMLRQYAGRLVCLVAKISEINNTGTELKVLTSDDKTIHVILSEPLEEALQGVIEIIGRAEKDGTISAQRLISYNGSEEFDMNLYNEAVKLTTNFPEIFAGSNANGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRP5</accession>
    <name>A0A6P8HRP5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">UBX domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116292197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555320.1">
        <property type="nucleotide sequence ID" value="XM_031699460.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031555321.1">
        <property type="nucleotide sequence ID" value="XM_031699461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRP5"/>
    <dbReference type="GeneID" id="116292197"/>
    <dbReference type="KEGG" id="aten:116292197"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10460">
        <property type="entry name" value="PUB_UBXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16119">
        <property type="entry name" value="UBX_UBXN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042774">
        <property type="entry name" value="UBXN6_PUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23153:SF38">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23153">
        <property type="entry name" value="UBX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="353"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031555321.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="52114" checksum="1DD6DDD7714EC55A" modified="2020-12-02" version="1">MKKFFEKAKLEIKFRKAGDGHTLTESNTGHRPSTSHSSTPAPRAVPCTSAQRAGEAALLRISQQEKAASKKPQSVTATWKHNSASTNTNSSGSPSLDFEKLRNEVKQEVFANKKQFSAPSQSASTLSQPLVAVKDEPMRLSVEGIYFKCPLCPVTVLQKEQDCHLKECLENMYTENPHMAAASMIQSLNKDKEKVQACIDILCKYIDNICNNPGEEKYRKIKQSNRIFKERVSTITGAIEFILACGFEDMMIKQEDKLESFFVLPSEKAEDQETLQTYKAVLLSTEPLKPTLDRNLKVFRPSSGTMQFELPEEFFSLSSEEIKREYNSKLEEIDKKCQLRTKAMREADKKPSKTYRFTLIRIRFPDGVILQGTFYSREKLRDLFGFIRQSLESDWQPFVLSDPTGQLKEEEATLNELGLVPAAVVNFAWDATIMADIVAASGSVQQGNYLKPEVMALIQELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSQ9</accession>
    <name>A0A6P8HSQ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116294741</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116294741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558253.1">
        <property type="nucleotide sequence ID" value="XM_031702393.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294741"/>
    <dbReference type="KEGG" id="aten:116294741"/>
    <dbReference type="InParanoid" id="A0A6P8HSQ9"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027998512" evidence="4">
        <location>
            <begin position="24"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="6">
        <location>
            <begin position="540"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="5">
        <location>
            <begin position="581"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558253.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="74398" checksum="AC7BE20C7B2A452B" modified="2020-12-02" version="1">MTNLGSIVCIWMCLVMNCQNVFGMIREISPLGSDYAVSELTIQQKQDMLDQHNHFRSMVRPTAANMEYQEWNDDLANLAQMWTNRCTWSHGFVKFGDAYPNKPTEXLRADHLGQNLAREYGKITNPETRVERWYNEYKYYRFSKFQSPMGPSQCLPRRICGHYTQLAWALSRYVGCGMTWCNKRFDNGYHPPSNPGETLVNCDYSPSGNVIGHYPYKTGKPCSKCASGKGWCYENLCRDCKDYNAECGQKLTREMCNTDTQKMKKVCPKFCNLCECPLSCVNGGTLIKDQCKCTCPTGWRPPDCSEQCRDKPFKSACKGFLKEGRRCDQPFMQENCPSTCGICDDGTGSGPAVITPNPVESIQPTQPPLVTPPPRTPNPTSEPWPTAVPPVSPTPGQTQPTNPNPEPWPTVRPTSPAAKTEGYLNQQGCIKDDNPKCSTWASEGECDWNRNWMMKHCCASCNTWKKGECKDTDHQCPLWAANGECEKNQKWMLINCRISCNQCKACQDLLDTCPDMALQGQCKKKPVKMLTKCRRSCGLCKVYDKEAWCPAWSAKGSCYGDNWTWMFNNCPRSCDVPLSSHQYCATKPDGFYSTSLTCKGYIECLSGATKFVSCPDGYMFQKYNKICKMTNEFECDQVDADEDGHLRKKSNVHRYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTK9</accession>
    <name>A0A6P8HTK9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031556020.1">
        <property type="nucleotide sequence ID" value="XM_031700160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTK9"/>
    <dbReference type="GeneID" id="116292812"/>
    <dbReference type="KEGG" id="aten:116292812"/>
    <dbReference type="InParanoid" id="A0A6P8HTK9"/>
    <dbReference type="OrthoDB" id="5971499at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008376">
        <property type="term" value="F:acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF5">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556020.1"/>
        </source>
    </evidence>
    <sequence length="686" mass="79641" checksum="079FCFAEF983B8CE" modified="2020-12-02" version="1">MVQHGADFCRIMLRIVTNKVIRKPKTIVSTIVFMSVLLYLQYSLSLKAKLRGEYTIFQDARLALLDNDSTFHNFSTLPAHLTELSLFDDENITSTLKIGHVNVHLWKKICSITLDSLKEYPLFPHWPDVRGCPKMPDNLVSIMHGSWNAQRVMGLLHPPISGLYQFEIASNFMSEFWLSPSRVPSHAILMARINKNTLHGLAYSKGVHIPSSKAVHLKSGKQYYFEVLNVINNFNYEQVQIKWKIPGSTVFSNILNEYISTVLINDTSLDARTRTVVQMSPSIHSDETLKRPNQQTWQNDITTTFGRFFNTSFTMQKLDDLMFLKQEILATAFNQCTYSPSYTKNLDFKPYRGVYFTHFSDVFPADDTGGKVWKGYVEKEDHRGNTLIEEPVVIDVVKKFMSSLEDTYPKQFSLANIVRVERNVDAKLGNRFFLEMVLQNNNTHLYHRVSGYFFLPQNSSVLCIPEGMIWKPRVLINVIINTKNQGPWVEHYIRNIGRVIRETHDEMIRIIIVDYGNNGLEPEKEFKRNGITNFEVIKQNGKFHKTFAIELAVDSIKDPNSIVFLTDLHLHMPNDIFDSVRKHTIQGKMCYTPVVFRLKHCSRPETEQTSVTGFWDSYAFGVFSTYKTDWNYFGGLNVTAFQNKWGGEDWEMVDRILKKELEIERLRLPHFYHFFHDKNNMWDNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU75</accession>
    <name>A0A6P8HU75_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558783.1">
        <property type="nucleotide sequence ID" value="XM_031702923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295170"/>
    <dbReference type="KEGG" id="aten:116295170"/>
    <dbReference type="InParanoid" id="A0A6P8HU75"/>
    <dbReference type="OrthoDB" id="5980582at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558783.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37308" checksum="37536D9313EDE877" modified="2020-12-02" version="1">MNLETDPNFEKESLSQCLNSRLTLPAGKIVPDPFSMKNFSTDFLRLPPFGLIDIFNHLILSKAEYDKEKLASFRSFDEYTLFQDGYVRSLGTKSVKDNDGAIFHVVFGEVIPTQKELTQEGMKHYKLWFILQPNGSIYXAFCRCKGGADQGCRXLGAALFELDDFLSNNRICSTSLPAYWNPKPTPNHKPVPFNQMNISHSKPKKGKRKVTPCDESXVDXFDPRPKKLRNDTALSAKQKFSQQLSEIDPDAAILKFLSSNPAEEIDQACSNQNVSTNENPTDQVQNICFNSISSKAEAFVAQNIISATNVQEQAKVFFDQLLLTEGERDAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWD5</accession>
    <name>A0A6P8HWD5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116295850 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116295850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559666.1">
        <property type="nucleotide sequence ID" value="XM_031703806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWD5"/>
    <dbReference type="GeneID" id="116295850"/>
    <dbReference type="KEGG" id="aten:116295850"/>
    <dbReference type="InParanoid" id="A0A6P8HWD5"/>
    <dbReference type="OrthoDB" id="5950649at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052876">
        <property type="entry name" value="Insect_Hormone_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39940">
        <property type="entry name" value="PROTHORACICOTROPIC HORMONE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39940:SF1">
        <property type="entry name" value="PROTHORACICOTROPIC HORMONE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031559666.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23213" checksum="BE37946BDA5A8338" modified="2020-12-02" version="1">MVFKQQAVFSPFKILLVLFITLMAINMSLGKTVFLLPSNQNGINEQCQPAKRELLLQKLGRAYNHHFMAMDFVDLTTKTADQLESLPEDALHESRYGSANESIREKRSSATKPAAWTCQTTSKWIDMGRNYFPRYYKTVKCSSNDCWFGHFRCRAKFFQFQILKRKSGACRKVISSSGVPSFEEFWELHEVDTALYCMCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWD6</accession>
    <name>A0A6P8HWD6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Helicase-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295877</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559693.1">
        <property type="nucleotide sequence ID" value="XM_031703833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWD6"/>
    <dbReference type="FunCoup" id="A0A6P8HWD6">
        <property type="interactions" value="1639"/>
    </dbReference>
    <dbReference type="GeneID" id="116295877"/>
    <dbReference type="KEGG" id="aten:116295877"/>
    <dbReference type="InParanoid" id="A0A6P8HWD6"/>
    <dbReference type="OrthoDB" id="276744at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16509">
        <property type="entry name" value="RING-HC_HLTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="495"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="792"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="873"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559693.1"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118325" checksum="1D0F8D85A3E32627" modified="2020-12-02" version="1">MNASETQCQANSSQRNSSQDSLQTPSQTISVQGSTNNRNSLNSSNLATTTYTSQEPEIPQAVLSQPCNLTSIITNANDQKGQVGCIVANTNFVGPQNPKLEGVFDTTFNAVPLSKHTQILNAIIKIQKELQKSLDSCSSPNSIAPSTSASLPSNPGITQESGNQGVAETDTQHQSNNSFPPVNIGACLLCGGDCGCDEADSEEDEENSFLPPPRMSSVEVDSLFGKLKEQDKDTPAEPASVINTKMHLHQKQALNWMINKENSNDLGPFWRENGPQEWFNEGTKKFTDERPTCIKGGILADDMGLGKTLTVIALIFTNHLDGKPMFMKTENPNSKKRRASKLDTADPTEPQNKKPSLDSASNDDDEVVVIKREGRKKEKKAVAIKKRKEEIMNKKRLLEDKKKKDPGAMFRQIFLPKILKKKERQENKIKKEKADSSPAQKPIAIDISQPSTSKSIPDITQIDDDDSSDEITDTPTRPNKLLIANPAPSGAAKATLIICPLSVLSNWTDQICSHVHPSVQLKVYMYYGAQKIQDLKYLRGQDIVLTTYPTLANDFRSKFSPLHKIKWLRIILDEGHMIRNKRTALSKAALDLEAERRWVITGTPIQNRIEDLKTIILYLRLEPFNDKNWWKKSIENLRNKRSELADFRLNTLIKHVSIRRLKDEKVDNSKLVELPPKQVVIQDIELSSEERKLYDMMQLDGQSIIRRYIRHDSVLKHYGHCFAILMRLRQMCLHPRLCKEALKELQQALDSAKQDKDDGAADDNDDNDDDDSRARLIKVLMEAIASGDSEECAICLESLNDPVITPCAHVFCCGCITDVLNSEGLAPKCPMCRAPVDEIDLLRVPEEQRNTNNETAIDVDEEDKFEDSTKINALISSLEAIRDKDPSIKSVVVSQFTSFLNIVEEYLDKHGFVHLRLDGRMRLHERLQALDDFNEPGNAATVFLLSMSAGGTGINLTAASRVFLMDPAWNPAVEEQCFDRCHRMGQTKEVIVTKYIVMDSVEERMLTLQEQKRQLMSHAFGAKAQSEEDRSRARVRDIAHLIGLRPARQGPNIGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZ24</accession>
    <name>A0A6P8HZ24_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116296633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560541.1">
        <property type="nucleotide sequence ID" value="XM_031704681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZ24"/>
    <dbReference type="FunCoup" id="A0A6P8HZ24">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="GeneID" id="116296633"/>
    <dbReference type="KEGG" id="aten:116296633"/>
    <dbReference type="InParanoid" id="A0A6P8HZ24"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031560541.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13711" checksum="E5E7FC2167861A10" modified="2020-12-02" version="1">MTMSTSHVYAVKTLYCRILSLHRGLPLELRALGDQYIRDEFRRHKNVTMEQGADFLQEWKMYADMLQQQQKQGLRNLGNDLSVNEIDSFSDEQIGQLFALHQEATTSSSEENKDKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZB5</accession>
    <name>A0A6P8HZB5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116297609</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031561729.1">
        <property type="nucleotide sequence ID" value="XM_031705869.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HZB5">
        <property type="interactions" value="848"/>
    </dbReference>
    <dbReference type="GeneID" id="116297609"/>
    <dbReference type="KEGG" id="aten:116297609"/>
    <dbReference type="InParanoid" id="A0A6P8HZB5"/>
    <dbReference type="OrthoDB" id="9993460at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="115"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="242"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031561729.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="58124" checksum="267E542B0FE6DC47" modified="2020-12-02" version="1">MASMTRAFTQLFAYKKSLFCMIFVVALILFIESFFYVYSDADESLLETIGEQFVKFEGKLGNDVHVIPDVPQKSPEYDENWMDSYSEENLYYDKVDHNLQNIKKPAAYAAKHKLPIIIWWTHFTGGNSIKRCPKGDCYITEARKFKTHPRTKGFLFYGTSFTAHDLPLPRLAHHEWGLCHEESPKNNPILHHQSTIELFNHTSTFRRHSDYPLITQFLNSIETLLTPPQFNLNQKKKNGLASIIYIQSGCNPPSDRDAYVEELMKYIKIDSYGKCLHNKDLPSKYVDPMTMDEKGFHDILAQYKFTLSMENGICEDYXTEKLWRPLILGSVPIYRGSPTVNDWMPNSKSIILIDDFKSPKELADYIHWLDNNDKEYLKYLQYKTEGVTNXNLSNFMKARPWGHTFSEQTFVSGFECLVCDRIHDNLKLESNGLPKKTHIANQDHYGCPRPVMFDFQDSKLVGKTYERRIWMDEYDQSKIQSEMLKQKVLSSTPKPLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZF4</accession>
    <name>A0A6P8HZF4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116294513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031557992.1">
        <property type="nucleotide sequence ID" value="XM_031702132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZF4"/>
    <dbReference type="GeneID" id="116294513"/>
    <dbReference type="KEGG" id="aten:116294513"/>
    <dbReference type="InParanoid" id="A0A6P8HZF4"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14095">
        <property type="entry name" value="STKc_DCKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000066">
        <property type="entry name" value="Serine/threonine-protein kinase DCLK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Doublecortin" evidence="13">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="13">
        <location>
            <begin position="170"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="467"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031557992.1"/>
        </source>
    </evidence>
    <sequence length="784" mass="89235" checksum="B526E7308B10EAAC" modified="2020-12-02" version="1">MMTAVRHTSKYSTNEQDMKKDSKIVTFYKNGDIYFSGYVVTITPRRYRSFEVLLSELSRITNLPQGVRYLLDRESGTRIEAIEQLQDGKAYVCASNSKLKRLDYGKKSGVLPQWGSKNKIELPALTNPPKVQGNQTSSRYVPLAHTRHAGTREHKQEATRNYQRVSYKARNVTVIRNGHKPRMSTRVLLSKRTAHSVNQFLDMVNDSLGVTGASNVRKIYTSRGKQVYEVSDLFLDETGIFIAVGNERFRVDDIENILSDDKGTPGNNKRRVKSLGKVSNTGMKHEEENKRTSKEHDDKPTEQDNKKSSLPVLPDLEVKKNKNNYEIRSKVADGGDNYSSIHQKPQSPRHKKTVSKQNSSTRENKNVEQRTDVNSNNVKLPQIGTGHNLVTSQEPQQATTTKGKTDNQDSPRGVGEEKEKLKESVEKEKIEKYPEQKVKKRPSKEFTHHEIEVEYSRVTDKKVEDVYDIGRKIGDGNFAIVRQCTNKTNKKEFALKIIDKKKIKGKEKMIDDEIAIMRKCRHPNIVRLFEDYDTPTDIYLVMELIKGGDLFDAISSSVKFTENVAKTYFRDMCKALAYLHKQRVVHRDMKPENLLVHERANGQAILKLADFGLAVEVKAPLFTVCGTPTYVAPEILEEEGYGLKIDMWAAGVITYIMLCGFPPFRSAKRDQDELFDLIQAGDYEFLSPYWDPISEDAKDLISHLLVVEPHKRYSAEKALTHKWVRLRSPTVGDLSKNLLGEDGVGKKSKKKFKAAALAIQGAQRFGNLADEFRTHRGEKFISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZH4</accession>
    <name>A0A6P8HZH4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296758</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560691.1">
        <property type="nucleotide sequence ID" value="XM_031704831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296758"/>
    <dbReference type="KEGG" id="aten:116296758"/>
    <dbReference type="InParanoid" id="A0A6P8HZH4"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020043">
        <property type="entry name" value="Deacetylase_Atu3266-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006689">
        <property type="entry name" value="PRK09237.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717">
        <property type="entry name" value="DIHYDROOROTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42717:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE AND RELATED AMIDOHYDROLASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039004">
        <property type="entry name" value="ADE_EF_0837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="59"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560691.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="46660" checksum="95DCF55CD3A4A2A2" modified="2020-12-02" version="1">MERQITSHLVIRNGRVLDPANSFDGIADVEIQNGKIVKVGKDLNIQLKPNEEFDATGCLVTPGLIDFHAHVYQYATPLGVNPDETCLARGVTTVVDAGSAGASTLPGLRKYIMEKSKTRVLCFVHVASHGLSAAGCAGVVKGGECDSLNQVDPESCAKCIQENREVAVGVKVRLSCSVTNDGQFEEEAYRRALRASXAAGVPLMVHFTHSSISVNESPDAGQLTCPGNLKKGDILTHVFHAHPSSIINPSTKKIHPSIHQARRRGVLFDIGHGFGSFSWTVAEICAKEQFWPDMISTDLHTKSLDGPTYDLPMVMSKMLTVGMPLVDIIRAVTITPASAIGWQSKIGSLSPGLVADVTVLRVEDVDMEIEDSQGQVRQAEKLLIPVAVWRDGKRFIVRKPDPLPGKNTTRLIENWDGLIVKDNKKPTPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZQ9</accession>
    <name>A0A6P8HZQ9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding protein RO60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa SS-A/Ro ribonucleoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">TROVE domain family member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116296927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560908.1">
        <property type="nucleotide sequence ID" value="XM_031705048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZQ9"/>
    <dbReference type="FunCoup" id="A0A6P8HZQ9">
        <property type="interactions" value="2192"/>
    </dbReference>
    <dbReference type="GeneID" id="116296927"/>
    <dbReference type="KEGG" id="aten:116296927"/>
    <dbReference type="InParanoid" id="A0A6P8HZQ9"/>
    <dbReference type="OrthoDB" id="6098064at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000033">
        <property type="entry name" value="60 kDa SS-A/Ro ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000040">
        <property type="entry name" value="60 kDa SS-A/Ro ribonucleoprotein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056800">
        <property type="entry name" value="vWA_Ro60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="60 KDA RIBONUCLEOPROTEIN SSA/RO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN RO60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25045">
        <property type="entry name" value="vWA_Ro60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="TROVE domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="12">
        <location>
            <begin position="33"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031560908.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="61988" checksum="A81289FC324CD283" modified="2020-12-02" version="1">MSIQQQQRPLDVEMHNADDETAPQNEPLSTKQVKNEAGGYTFVVDNMCRLKRFIVLGSEGGTYYAGEKELSQQNATCLMALIEEGKGPEAVEVIKEYSVEGRTAKQDPIIFALAMFARCSDLNTKRKAYEVLNDILRIPTHLFIFVENCENLSKPKTGWGRAHRKAICKWYTQKKAKNLAMHVTKYKQRNGWSHRDLFRLCHIKPDNPSVQFVVRYVVKGLTDELKKQASLPGVSQDISNVYEFLDVVERAKDMNEDELTAAIRGHGLVREHIPTDKLKSPEIWKALLEKMPMTAMIRNLGKMTSIGILEPLTDEADKVTTKLRDMEALKAARIHPFNVLVALKLYGQGHGDKGKLSWEPNSMISSALDDAYYLSFKAVEPTNKRFLLALDVSGSMSWGNCVGTPGITPAVATAAMAMVTARTETKHHFVGFSHELVPINIKKTDKLETVMQTISHISMGGTDCAQPMLYATKKKLKVDVFIIYTDCETHSGKIHPSAALKKYREQMQIDAKLIVVAMTSNGFTLADPEDSGMLDIAGFDSAAPQVIREFVMGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I162</accession>
    <name>A0A6P8I162_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transient receptor potential cation channel subfamily A member 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116297397</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561478.1">
        <property type="nucleotide sequence ID" value="XM_031705618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I162"/>
    <dbReference type="GeneID" id="116297397"/>
    <dbReference type="KEGG" id="aten:116297397"/>
    <dbReference type="InParanoid" id="A0A6P8I162"/>
    <dbReference type="OrthoDB" id="1661883at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF3">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="903"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031561478.1"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140911" checksum="2168EF8DD1211631" modified="2020-12-02" version="1">MAENKEGDVLTTPLLKKREDVEMSSVNSMPSIAIVPSRPSKTHHHLMERETSENSSVSLHQAARDGKIDLVKRRLEQLGKGHKKINQQDTYNTTPLHYAVRYNHVEVVKLLLEYGADIEAKGEDEATPLHYAARFCFAAKHSSRGTPRTSRRTKDALPKPSASTNDLVGITLKKDEKEECGSSSSLSKATGKERLFGNFTKKRESLLGSRLFKDFQIGEKKTTNVKDNSAVNSTQKNGSQDTMIGFLISQKAKVNAKDSYGSTPLHYAVAKKNIEAVKELLKQPSIDIEAKDKTKMTPLHAAASHGTVVVTKCLIEASANLRSLDEEQMTPLHFACVEGHLDIAKLLFEAAELEGGWSTVSKMVTDQDREEETPLHLAVEGRNPELAKLCLDKGANVNAVKMNMSTALHLAATDGDRAIVRMLIQHDANVEAKNALQETPLHRAALFNRTDVIEDLLKHGACIECRDKDKDTPLLIAAGKNHIDAMKLLLENGADLGAKDVNDCTPLFKAASEGCIEAIQLLLKEPKGKSLVEECDKYENTPLHIAARKGYVRIIALLFKYEACIDSKNDEGATPLHLAAKYGKIRSVCALLNRDPSIINDEDDGSNTPLHLAALYGHSTVVKELLDRGAAVDARNATLWTPLDCAAARGCVEVATVLLQHDCPVDPTDKSKTTPLHLASREGHVEMVKLLMSHKAKINLKDSAGKNCLDIAIENNHKEVVQTIINHADWKKAMKNRYQDGKNVTSPMRKLIKKLPEVAGYVFNRCVTSNGHPVDNPKYAITLDYEFLDDVNLDWAAGSSESQDDQDEDHGLDAVMEKIKSALPENATKQTQLKANHPLMLMVNKERVKLLSHPLVTYLLRYKWKKFGRYVYYSKLILYCIFLFFLTGYALVTTKSMPTFKCVNATFCACQVNFGEIKTGSDVVWRMIGRPLVILTACISLLLEFLNFCYVWRLYLQWHRLIEVSAYVVSLIYVIDEITVDGTTINVPNGSRCFVWHNSVGAAAVYLSWTNLVLFMRKFPKLGIYVVMFTHIFKTFARFFVVFFLFIVGFGLAFHILIYEQVPFATPGRSMLKTTMGMLGEFEYDTVYNENEVPPIAWPLYVCFLVINCIIIMNLLVGLAVDDIKGVQEKSALKRLAMQVDLVLDVEKALPAMLRRRFVSTEEVVYPNENKYWTIWSFWNTGNTSPARIINDAMNPEKTPIEKLQRQQDQLKEDVTNLNIKLKSVLQHTTHLEMMMKAMMKHHGVSVEEEQEGEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1M6</accession>
    <name>A0A6P8I1M6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Rhodopsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC116297331</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561410.1">
        <property type="nucleotide sequence ID" value="XM_031705550.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561411.1">
        <property type="nucleotide sequence ID" value="XM_031705551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561412.1">
        <property type="nucleotide sequence ID" value="XM_031705552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1M6"/>
    <dbReference type="GeneID" id="116297331"/>
    <dbReference type="KEGG" id="aten:116297331"/>
    <dbReference type="OrthoDB" id="5960118at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031561410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031561411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561412.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38632" checksum="2FDD8FE4A634BABB" modified="2020-12-02" version="1">MNSKPLSPTGYAFVTCYLGILLVAGVISQIITIKVLLVKDNRNKHLTPYLLNIVASNAIIILGSFPTTFLSSLNNGWYFGDAVCRLDGLLTGIGFTAMIATMTYITIKIYLIAKNQYLVINAETPVQCGRPYMKILIAIWVYSIIAIMPPVVGLTNMVLEAAKTNCVPDWAPKRVPDKIYIVGLTLVAYVLPVSVSFVYLWKTRLIISLHINLMNDRFMNLKLGNLKNIYRMSAFAVSFFAIAWLPYGLYVFISVISGKEDFGVEATLVPALTAKSSVVVNPFIYAVVLPKFRHSILKILGLRRRSGGSNSMRSFVHEPVTEMETLRSAGVTRANSRARGNVCKCGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I350</accession>
    <name>A0A6P8I350_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116297784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561936.1">
        <property type="nucleotide sequence ID" value="XM_031706076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I350"/>
    <dbReference type="FunCoup" id="A0A6P8I350">
        <property type="interactions" value="2850"/>
    </dbReference>
    <dbReference type="GeneID" id="116297784"/>
    <dbReference type="KEGG" id="aten:116297784"/>
    <dbReference type="InParanoid" id="A0A6P8I350"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="225"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031561936.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="51912" checksum="7654FE9ECCF1B9B1" modified="2020-12-02" version="1">MAEHDLTSRMGCFLDRHLVFPLLEFLSVKEIYDEHELLKGKLELLSNTNMVDFAMDVHRNLYPDEEVPTSLKEKRVEVVSELKELQAQTEPIMNCFTDPEFTIQMQSTRDGRQLFEYLEKNHDIKPEMMDILYKYAKFQYECGNYAGAAEYLYFYRVLAPGGDRNSLNALWGKLASEILMQNWETALEDLNRLKEVIEGNTSAGTLQLLQERTWLIHWSLFVYFNHPKGRDLIIDLFLYQPAYLNAIQTMCPHILRYLTTAVITSKRRRTVLKDLVKVIQQESYTYRDPITEFLECLYVNFDFDGAQTKLRECETVLVNDFFLVACLDDFIENARLFIFETFCRIHQCISISMLAEKLNMSPEEAERWIVNLIRNAKLDAKIDSKLGHVVMGVQAPSVYQQIIEKTKGLNFKSQMLAGNIDKKLSTEKGGYDAYAGSWNMSYESQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3K0</accession>
    <name>A0A6P8I3K0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tolloid-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562423.1">
        <property type="nucleotide sequence ID" value="XM_031706563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3K0"/>
    <dbReference type="GeneID" id="116298182"/>
    <dbReference type="KEGG" id="aten:116298182"/>
    <dbReference type="InParanoid" id="A0A6P8I3K0"/>
    <dbReference type="OrthoDB" id="5971537at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027553077" evidence="4">
        <location>
            <begin position="24"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562423.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38897" checksum="B64E3D65D5D24FFE" modified="2020-12-02" version="1">MSILFFNILYFFLVCSLLEGAHSSIKTFNGISGRFSSEKESNGFYPNNFSMEYRIQVPSGRRAMLSFKNFSILGSMPNCSEDYVEISLGCQNIRSIGKYCSCGLITPLPFDFYSIDECMTLTFKSDVKYAAQGFVAEYSSDLKNQPVSNKDTCTAISNQHNSSVSNIFTPLWPNNYPTKTSCSWNFENPVNYSIIIQFMDFEIERTVFCDPNEEKDDRVMIKASRKFVSGPFEIVNKRICSLMNDVDKRKIFRVIVPDIYRKIAVNFINDADSHTATGFTAGMISYKSDPPDTQSCRVRLVPPRPPTPSMSPNMLLSSANLLLFATFYFAFCFTLKPCTCVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3S3</accession>
    <name>A0A6P8I3S3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116298800</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563214.1">
        <property type="nucleotide sequence ID" value="XM_031707354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3S3"/>
    <dbReference type="GeneID" id="116298800"/>
    <dbReference type="KEGG" id="aten:116298800"/>
    <dbReference type="InParanoid" id="A0A6P8I3S3"/>
    <dbReference type="OrthoDB" id="5989851at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563214.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="62591" checksum="898A4AB34BC0975B" modified="2020-12-02" version="1">MPCSQTRELQSKVKCEKDEVVLAKAETLGQEGNPSKHNNVKTSNNDEPLEEQRKKRDHELKENKPLHTEEDKNVYNTVVQRRNSDGKIENIPNYVDKDVNNLNDDVVRQKPNGLDEKTLTRIDQNNTNDSDKKILFILVESEITQVGNNNHMMIEDERKNSEESSSDLHMSCIVKKHRGRGRKVNRRPRSRSNSSTMNKVYIAEAVLKNIPPASPSDSYIQLCRISDEVMLQLQVVRDNGKWELFDDIVVTLSRKYQSKEAEIVILLEKSMAACYQSRLEESTEMILKAIDMAKETENSSVLTGRGFHYLSGVYRRQNLMGKANDCVIKSEQNFHNKHLTLDSTFLAYERASVLMDFISKCPNPPASMINDAKAGLIKCIDGCTALEEDTECLRYVKKHHFAFIKRAMLLLDCRTASGRKRTVSQESIKEAEKSLKTLRTRYWDGIAQGEKVQYFLGLADLYFRLEDFPKAEETANEVLSMAKTFGFNTEIKPAQDRLEEIARKQQVKKEPCCYGNSGYTYTSSDISEGQNGDVSSSESDFMETPSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5L0</accession>
    <name>A0A6P8I5L0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neudesin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116299345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563849.1">
        <property type="nucleotide sequence ID" value="XM_031707989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I5L0"/>
    <dbReference type="FunCoup" id="A0A6P8I5L0">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="GeneID" id="116299345"/>
    <dbReference type="KEGG" id="aten:116299345"/>
    <dbReference type="InParanoid" id="A0A6P8I5L0"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027670450" evidence="7">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031563849.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18111" checksum="3041620097782C2B" modified="2020-12-02" version="1">MAAPSLVLVIVAVSCCIGVQVKDKAPHAPFSDLHENLSTESGHRLFSLEELSSYNGQNSELPIYVAVKGVVFDVTQGKDYYGVGKPYNVFTGKDASRAIAKWSMDPKDMIPELDGLTKEEFDRLEDNFENVYMKKYPAVGYVRGYEPRPEEDNLIWSRQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I610</accession>
    <name>A0A6P8I610_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">A disintegrin and metalloproteinase with thrombospondin motifs 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116298937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563378.1">
        <property type="nucleotide sequence ID" value="XM_031707518.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563379.1">
        <property type="nucleotide sequence ID" value="XM_031707519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I610"/>
    <dbReference type="GeneID" id="116298937"/>
    <dbReference type="KEGG" id="aten:116298937"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF200">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031563378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031563379.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25216" checksum="9CF46BDD044BC153" modified="2020-12-02" version="1">MGDTNVGYDYFYYKPGQGSKTTFVWRYKATGSCSATCAGGHQAQIVTCHRNDDESRVSRKFCDLGNKPSELVPCNTQVCPAKWEPELWQPCSRICGGGNHSRLVPCVQQVTSEIYRNVEYHYCNISARPPLTSTCNEVDCGIAWVPGEWSKCVIGKHGGTATREIKCQNILANGTVLTLNRNHCEIVGNMLPEAIMNCTLHASSHYVRPSSLGNLIAVILTCLMFGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I691</accession>
    <name>A0A6P8I691_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KICSTOR complex protein kaptin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562856.1">
        <property type="nucleotide sequence ID" value="XM_031706996.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I691">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116298497"/>
    <dbReference type="InParanoid" id="A0A6P8I691"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029982">
        <property type="entry name" value="Kptn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435:SF2">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="D or N" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031562856.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46578" checksum="5A5425DA3CB116C8" modified="2020-12-02" version="1">MAADVKVKFEEAHFTSLPSQTNIYGLTSVSDEPETXKVLVSSLKGRVFLVEYGNKWDNPVSRELPFTYIPAGDAEIVSIDSFVRPGSKGHGLVVGISFILFNVHSSHGNQKXFLNIYSCVEEGNEYCLDSIAEGCQHIELDFIPFQLYHTXIRNGETVENVFLLAGSDHKVHMYREVMEADHQSFKEQEIEAFFPELQNLPSSAMWMDIQEKSEXQRLTAVGCQNGFVQLSVVDIQEQPSITSQWTVQHDGPISSLRLFTIPTTRTNTLSDASSTDLHEEKYYLLVCCTIEPCSLYVDVLSQGFKRLVTLPDSDKFDCVLCTCIADVDWDGNNEILLGTYGQELLVYKLTSRSENDSSLDMTTTWQRSFSSPLFAIDYLDMTGDGVREIVVACLSGLHILQHQLDDVAKVCTTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6C3</accession>
    <name>A0A6P8I6C3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116299609</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564144.1">
        <property type="nucleotide sequence ID" value="XM_031708284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6C3"/>
    <dbReference type="GeneID" id="116299609"/>
    <dbReference type="KEGG" id="aten:116299609"/>
    <dbReference type="InParanoid" id="A0A6P8I6C3"/>
    <dbReference type="OrthoDB" id="2157354at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564144.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="55772" checksum="F370FFE1635C79EC" modified="2020-12-02" version="1">MKMATCTPVRPSQLAATMYGEYPRTTMTPEPVLRKCTPFCDKNKDCPEHHELLVAIVNCTDMLGSLSNLDSLKECVDKYIKKGWNKDDDVPDPVIENRFPLIHWAASLGKCNALEWMLASGFNPIAKSSGVGETALHRATAWLYKSRAKFTVKELTPKYNKMVSLLKETLHVKDEAHGETPLHTAAGMLVNGDHKPNFFQTCVELIVKQARKMGDQCPGILNAVNDDGDTALHILSCGERHKIEFCCQAIRTLIMAGADRSIRNNVGKTSLDIALARGTESIVEELIKVIDTGDNGLLSGLNSEDPDSYSYSALATPSPPLSNISRSIESPMHPGISDEEDGGYPHIAHVQSVKVEPLEDDQDVEKQIKQMQEEQASSSSSDGHFINGLDMVDGSGLLKHLCEAGLLHDVSSLVGKARLRDEGNLRKVQVQAKEVDAQINTKLKEIDRMKLEVQSLKLKRKRCDEECERLRKRLQSCVNVMKEIPMTISESRGEKPQENDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7P1</accession>
    <name>A0A6P8I7P1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116299514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564033.1">
        <property type="nucleotide sequence ID" value="XM_031708173.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I7P1">
        <property type="interactions" value="3196"/>
    </dbReference>
    <dbReference type="GeneID" id="116299514"/>
    <dbReference type="KEGG" id="aten:116299514"/>
    <dbReference type="InParanoid" id="A0A6P8I7P1"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031564033.1"/>
        </source>
    </evidence>
    <sequence length="682" mass="77551" checksum="8B7211A6CF8FF761" modified="2020-12-02" version="1">MAGKSESSMDEGALVTLIPECQAGGKITGHWSTGHGITVHASEGKPTSAQPLGHYRFPVMHEVKWHADVHTTIMRKLINETHGIFLDLQKLPEAGGTSRKSSLLTISRRYRAVLRACLLQLKDKIDIEPMTVDGNHNTGTQKQLLTFIELVWHLCEILFIESLPGGAVLPRLLEWSKTEDTDKYIEQVLQYASPHESPXYWPAIYSLVLHGQLNDARELLAQHPDSRDQPGSYDLFESMDELLRKMPLYQFYMGQTSSEFLVKWNHWQHECKSQLESDTYVADPYLQTLCEILAGKEEVFENSIIRDSCPTWYQMLTAKLLYCNPVVKVFDLQYHTESCIELFGGDLGSLDKILLSAFEFDVSGVIKQSSESFGSWWFVAHLTDLLEHAGQLDSNQISSPISLREFLLLEYSASLMSHHSLWQIAVDYLKQCPQYGRAHLEEYVEHLPLETEKKALKVLRLCEDLDMPVQAQSICKTMSMRALRNSRLGSALSWCLRSKDSAFAAFISDRFLEEYIQCGGFSNLDLIDNLGSAMLLSDRLTFLGKYREFHKTYEECRFEDAAALLISLLTSKLAPKSLWLTLLTDALPLLEHEKVIFSSNQTYELMHCLEEIRLSFRSSEYMDLSEDQGGMRKQGSKTGKKGKTNKATKAQGEEEQDRIDLLRLAMARNLARAILREGQLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7Y8</accession>
    <name>A0A6P8I7Y8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycerol-3-phosphate acyltransferase 1, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560815.1">
        <property type="nucleotide sequence ID" value="XM_031704955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7Y8"/>
    <dbReference type="FunCoup" id="A0A6P8I7Y8">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="GeneID" id="116296848"/>
    <dbReference type="KEGG" id="aten:116296848"/>
    <dbReference type="InParanoid" id="A0A6P8I7Y8"/>
    <dbReference type="OrthoDB" id="5962536at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF23">
        <property type="entry name" value="BCDNA.GH07066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="276"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560815.1"/>
        </source>
    </evidence>
    <sequence length="855" mass="97845" checksum="A8CF27315BB6EC0C" modified="2020-12-02" version="1">MDSEQMKKIEEVYKKWEKKSSGGRYAAGSVASTGMQTGRSEGGNDWVRKYGYYPQAPTRRPARSKRRKQKQDDFEPMLPVERKFQVPPAIIPGEFSRERPFMGKGCKTCCSDSVQLLYHDRIPSRGMHNILNIAVYHKQNLFRRTFCHMTFIWNCDVSYDFPDVKKSVVNSERVQNCIMNSVFQESANGNNAAQLTEKELKSLDKARQQQITSLTKKANEIINRMAAGIYRKLIRFTGWFLFKLFGRLLTSIQIHRGQIEMVQQATQVLTQENKPLVFLPLHKSHLDYILVTYVLLTCDIKSPHVAAGDNLGNMFLFSWLMRHLGGFFIKRKLDHTSGKDDLYKCTLQEYIQQLLIKEQYLEMFIEGSRSRTGKAMVPKSGLLSIVVNAVLEGIVPDVLIVPVNISYEKTFETSYSRELLGEPKRPETFYEAVKGIFQVLGSRYGHIRVDFSQPFSLKEFSENMDLSVSMQEFGSTMVARSSVTSSPASSMLRNVSDLSLSDFGEDKCFSLTKVLGYHVIYDAVQCSAVMSTNMLAFLFIYNHRKGASFDELVYSFDELRQEILSRGRDVGFSGKTPDVVQHALELLGNLVDVEENGEEKYIKPRLRVPEVIDLHNYSNLVLCIFALEAVVACSICAVAQENDIEITDIEQEQSLPQTMIIEKAEDLCELLQKEFIFIPPCASLEARLKETIDKFISSEILQSTTQTSSSSRQWSTWDDEEDSYSAPEPEYKLTTSMQELSRLKFLQSLLSPLIESYWVAACGLLWLPGQAFTEDEFLRAVHDCSKERLQQDVTMYPESCSLEPYRNAIRIFKENMVLELFKESDGTKTLLRLTDRYNNQESIFEFISSIGQFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9V8</accession>
    <name>A0A6P8I9V8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031564818.1">
        <property type="nucleotide sequence ID" value="XM_031708958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9V8"/>
    <dbReference type="GeneID" id="116300162"/>
    <dbReference type="KEGG" id="aten:116300162"/>
    <dbReference type="InParanoid" id="A0A6P8I9V8"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031564818.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="54440" checksum="E5BD7239FF1560BE" modified="2020-12-02" version="1">MGSARSFRYFTSTAPLLTAFWSRWFCLFAAAITLLSTTALTSGLELQQVVIISRHGSRGFLTKDHTTLQETADSPLTIRGMDQMYRAGQYVRQLYNSTTTSFLSEGYNGSEVYVRSSDYQRTLISAQSFLLGLYPPREQTLTNYAGVFKAPYDIQQVPIHTVPVREDQLLRGWLRCPTIQNRISEFYKSETFKKKERDNADFLKTLESITGMSDIDLKDFYNVYDFIHLHRVYGKMYLNLTEEQWNKVVDLADWLEYHKYKKEMVESMGAGLLVNDIAQNFINTTKNRRKAKLLYYSAHYPTIVSLFSVLGVNQINKTLQTIPYYASLVFIELLKGDNQDYYVRFAFRNGLESDTKDSFQYYAIPGCDRKACPLKTFNKLLGSLEVRNIEAWCQMCNNNDLDACEVGYVYKRKLAMTAVGGFFVRVFVTTIATILMVGCWFFCLKKRCLPGDNYRPRRGLPDLEHRGPLAGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAR9</accession>
    <name>A0A6P8IAR9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116297671</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116297671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031561805.1">
        <property type="nucleotide sequence ID" value="XM_031705945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAR9"/>
    <dbReference type="GeneID" id="116297671"/>
    <dbReference type="KEGG" id="aten:116297671"/>
    <dbReference type="InParanoid" id="A0A6P8IAR9"/>
    <dbReference type="OrthoDB" id="10296420at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028102285" evidence="3">
        <location>
            <begin position="25"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031561805.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44804" checksum="4E968431AE2EA8C7" modified="2020-12-02" version="1">MMGIQGRRHFALLVLMSLSLLISSEETILRNRTSMAQDLKECKKAKKDISGALGSLLVIETIFCCYVLFSWARNSRFNLKRKERRSDDPEKDGSGFHMYTEADEGTKQDQNHPKNGQPLASSPQSGMALRPGHQHLPKKSRATEKIPGKRFIERLMARRHNKPNVAQNLDATVLPSNEHVIEEDVGGLVYSEPYEDKVSVATELKFKKPGSFRGKINKDPSPEKEIQLVYYHVLEESTEPNANLSTSPIEYLPGPSEEAREDVYYYCDSNNPENEKIEDSKTAPPKPLPLVASNNSELEDDTYYSCVAEESTNSPSQTNPKKVLLPLPQISKEMSSPRPTTSAGFAAAQQKTHFHGWDNQTRNQTAKPIDKSSLKGNLMINAHMIQEMKSRVANKKFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB97</accession>
    <name>A0A6P8IB97_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116299944</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564536.1">
        <property type="nucleotide sequence ID" value="XM_031708676.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299944"/>
    <dbReference type="InParanoid" id="A0A6P8IB97"/>
    <dbReference type="OrthoDB" id="5983664at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF39">
        <property type="entry name" value="E2F TRANSCRIPTION FACTOR CC-MB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564536.1"/>
        </source>
    </evidence>
    <sequence length="943" mass="108099" checksum="B03DF21306AAFB45" modified="2020-12-02" version="1">MGMWLLRSVXLRFKGKLARFVVILLVFLVAFNFFLFKRETRDETDRSNHLKSILIDTENGEKTFKSELETRLNGLHRAGGDGGKRKRRSGKNLKHSLRKKFQGTENVNSELVTATKLQDLIEEVYPSNSIKHENKPQTKPLQNKEGDKISEESMENVDREDKLVANPVERELIPYSCPELFISRIEDIQYGKCKPHKPTLESCFYAEQLYFLDKNLIKCKNKYTVEICNVKLDKTYQDIGVSSIHVKCDRSLCSEKWYSTSLAVWTLDPRNGEISRLQSFSSIIKMEEELPRIMIETIKKKINFVVLKCSRRKDGESVSQLIPIDPRLTIIKNAGTKNSRPKKDINVNILLLDSVSRGHFYRSLPRTINLLKNWSSSEIAPANVFDFELFQAIQGHTAENTHALFTGKTLPPHLEDEFPPVEMGVAFGKYVKAGYQTLWQEDLCWKGSWGLMTDMAVMEWEELAYKLRENFIDSIGITHSSCEILKAYHLVTPFNGPKGDQICYNGRFQHEYLMNYTLDTIDAIKSTPTARPLLSYMSLSVGHDNNGRRIQTLDQSLADYVDRLGKDENTLTLILADHGNTYTEYTVTILEGRFEMYHPSLFMIVPKNVAKMLGSKAMRALRTNQRRLVNMYDLHHTLMALAGPLDKGRVSPRGVFTPIHINRTCNDIKLLTPNLCVCEGWDSPTTNDTLKISLVEFAVGEINNLIDKTFLEGSKGKKNSFPLLKSCRRLVPVRFENVRERINQKGLLRTTMDIHVKSLEENPGQTETFQVEIESKEIPDSNSMDLKLVHFDRMSVFEKYKKCSDIGVSPLLCICSNTPKPHLLDDSERKIDISIVKNILDSFQAQATVEFVDEQECVLLVRRHHSKESFSTELANLCLDFDIAVFVKVDDLDNMKLSRNLPAEFRIPAGSVRFVFAARKDLDYWTSSFDIKTRVTKIKNRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBN1</accession>
    <name>A0A6P8IBN1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein PRY1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564746.1">
        <property type="nucleotide sequence ID" value="XM_031708886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBN1"/>
    <dbReference type="GeneID" id="116300113"/>
    <dbReference type="KEGG" id="aten:116300113"/>
    <dbReference type="InParanoid" id="A0A6P8IBN1"/>
    <dbReference type="OrthoDB" id="5958669at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027745460" evidence="2">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="130"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564746.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38466" checksum="73DC96832FAC0CBE" modified="2020-12-02" version="1">MAWFARIMVLVIYASVTCKSGLSGRVGKFQIADNSVKGEGTYSLNNSTAEINLHLLIGNTLKQEQQQMKIPVMKPTESTKQTGRESGTANQPPPGPAIQTTSSSKDGNNPQERPLKPLQPEQELSDEDMAFAYDGLRGHNKFRKVHNSKLLKLDKKMTADAQNFARQLAKLGTLKHSARDSRQGQGENLAMGCSSGDVTMSAETATKQWYDEVCKYDFGNKSFQKPCGHFSQVVWKASDRIGIGQAKGTKWGMNCTFIVARYAPLGNIANLTGDNVEKGSFDQSYCNTVTRASLEKNSGPQTQDENEENPGYYPNYGLNEGFLNDEGEGSKLVGFREKIPRANFKIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBS5</accession>
    <name>A0A6P8IBS5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116300167 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116300167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564821.1">
        <property type="nucleotide sequence ID" value="XM_031708961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBS5"/>
    <dbReference type="GeneID" id="116300167"/>
    <dbReference type="KEGG" id="aten:116300167"/>
    <dbReference type="InParanoid" id="A0A6P8IBS5"/>
    <dbReference type="OrthoDB" id="5968702at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="285"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="871"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031564821.1"/>
        </source>
    </evidence>
    <sequence length="976" mass="111958" checksum="0934C769A1DBDA35" modified="2020-12-02" version="1">MLTSCMVVKMSGNRYKGSLDRRKLQPFHGAIPARIYSHPPLYPGEQIIFQQDHIVCVDSFDSHSEGVLHLTTFRIIFTGNYCKELYSAINDKNSMFDEDAEELSKKGSRRQSVSSKSVLANNQKNHSKPGTEVYQRQQIRLAKCPSPLKYSQSVKKRSNTSYDVAGLDDPNTPKLMTYRPLVLSNLEHIKHVYDLELSIPCTSIYDIRKYSKKNLPKGKSIFLCDGFEILCNNIKSHRFCIGLQSCYDADSIIKLLTYHAKPTFSRLFAFAHKSAIIVPRKTCSILESRDAPNFYKFNDEYIDRLGLLSTNEWKVPSHVCEHYPMRTLVPSTITDVDLKNVANFHRNDCYPAVCWKHKKNGSVMLRSAIAITRRGLLESRCEHDETFLNSVCQINQYAAKNKLVVFSEQPKQSGAGLLNTPTQRMNDATGQLTPEQGETFYYANCKFVYVDTAPDFKAIRQSAFKLQTFLASTIEDSKYLTSLEETEWLSQISELIQTGTQAAVAMDCDRSSVLFSYGDGFDRTAQLTSLTQLLLDPYYRTFDGFQILIQKEWMAFAHRFVDRTLPAETPDEHGPVFLQFLDCVWQITQQFPFSFEFNSSLIETIAESAYSCRFGDFLANSDYKKKGVHERSASLWTWLNVASMSDPDRFTNPRYRPNPSALFPRFNIPFLKIWTFYSSTCKQENVREARKAGQLQGLKLEETYKDLLDKFKLLRQKAECDTTQDNGLTNYPNPISNHVTFTVSDSSSSTDSINEEQSDLVSSLTSTLALDSYNSTDGVKPVNPERRMTRSRSLDDMLNVSNQTTLKRASLKRKVGGSKFYTERLLDELNREPRKRFVVPQPIQEKYNNLQEYLHGTGVNFSTENTVKITDKLCCGYLVKQGKIHKSWRKRWFVLDLEKKCLAYFESEKSQHPKGAINYQSIVEVHRHKRSSKKKKDFKFDIVTPERTYAIETPNEINMNIWLACLTIPPNAIEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBY4</accession>
    <name>A0A6P8IBY4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Lutropin-choriogonadotropic hormone receptor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116298719</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563117.1">
        <property type="nucleotide sequence ID" value="XM_031707257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IBY4"/>
    <dbReference type="FunCoup" id="A0A6P8IBY4">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="GeneID" id="116298719"/>
    <dbReference type="KEGG" id="aten:116298719"/>
    <dbReference type="InParanoid" id="A0A6P8IBY4"/>
    <dbReference type="OrthoDB" id="1883493at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000156">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028370276" evidence="16">
        <location>
            <begin position="23"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="613"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="937"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="970"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031563117.1"/>
        </source>
    </evidence>
    <sequence length="982" mass="110993" checksum="2E884BF02C59BDC9" modified="2020-12-02" version="1">MKRGRREFWLICTALMIWELHGLNMEETYSACRTTCECRYLDEALVVKCRSNKLREVPQEIPENVTELDLSDNDITHIEDDIFRNFTHLRRLFLQNNSIRKLPEGVFDNLRALERLYLKDNLLEELPTFRESLPSLTHLFLSANKIRDILPTHVTRIPNLQHLYLDHNAIKKVPSTLTQLTKLTYLNLNFNNISEIQKNAFRTLKHLTDLKLCCNGIGKIEEGAFPDPLVHLNLLHNDISSIPTKALKSLNLLQNLELGGNPIKCIHDYAFDGLHNLMEIDLSWKDIETVEHNAFVNLSKIIRLRLIHVKLTRFPNLTGTTSLKILTLESNAIPSLPEDFCKMFPHLYDFNANMNRIKRIPDMSRCSSLEILKLDYNRITTIGSSLQGMKNIQDITLNGNNIKEIPANVFKGDSLLNTLKLAKNNIISIADTAFVPIDQLEILDLSHNSFPRLPSQGLQNVLELDVRGNLKLNKILSDTLPNVRIVKASYPYHCCSFSGKMYVTNAEESKWNWAVSDKYLRVDQFENSSYTDGEDGVSGFGSDDSDSEGSASSDSENSTSNENPGKSAGTHKTQYKKVNCTPLPDPFSPCNDFMGSWLLRVGVWFVFLLALFGNATVIAVILLSNTKVDVSRFLIMNLAMADFCMGIYLGFLAFVDATTIGSFMHHSVDWQQSHGCQTAGFLALLSSEASVFTLAVITIERFIAIRHALHVHRKMSLRKTAVVMTFGWIMAIVIATLPLYKVSDYTKVSVCLPFETGDVKSLAFVSLILSFNFIAFVIIFVCYVGIYHEIRGSNAWNTNDTQVAMRMALLVVTDFACWAPIVIIAFPAAFGKSFVSLEEAKVFTIFVFPLNSCANPFLYAIFTYQFKKDCVNICRRVKNSSAPQIQITLAKKRTVDQRRGSQGSAIYYPETNSDGRLTLKIPGIRFNRRYSLPAAFKPLQKEKKSPRGSSQDNSQCSNENATEQTTLTQEKLRPLIDRRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICX4</accession>
    <name>A0A6P8ICX4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH3 domain-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563035.1">
        <property type="nucleotide sequence ID" value="XM_031707175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICX4"/>
    <dbReference type="FunCoup" id="A0A6P8ICX4">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="GeneID" id="116298651"/>
    <dbReference type="KEGG" id="aten:116298651"/>
    <dbReference type="InParanoid" id="A0A6P8ICX4"/>
    <dbReference type="OrthoDB" id="10254483at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035848">
        <property type="entry name" value="SH3BP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15126:SF4">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15126">
        <property type="entry name" value="SH3-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="62"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="415"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031563035.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57203" checksum="494227416CB5CFDD" modified="2020-12-02" version="1">MSINSSSWRGSSLPPFHPRNRMDSNLSENRGRSLTDVSSVLAPKYPEPFLSIPAQVLVQDNCRVHCGMVRKENRFNKWQDRYLVLHKGCLYYYKDSMDKTAQGQFSLSGYRLSTAPEKTKYQWTFKLTHIQPEKRKYFFSAHSEKELTEWLDKIAEDVKEYCEAVGTKPGYSSEPLQESYNSSGSGGSCSSIASGGEDYDYPLVDPPNFNQIREQMRQNSQIARDLAGNSSESDPTYCPPPPEFLQNLNSSIASVTSRTVTEHKNVTIITGGKASVDVSTILKRKDTIREGEPLPPTPPKPAPRVRTLPSRTPVSCTSEVRLDERPQVPPRPTPPKPLPRPPTAGVGPSPVSSATLSEEFDYESDYLPIIANDDDQPMPQPNRTMLERMRPEGNSFKERFTETAPCLAELLPDSAYRTDYDKTDAIPLLLGKEGVYMIHSSTRAETKKALSVCVGDKVKHFILFRNKEGYALDPYGPRFKNKRNLLDYYHENSLPNQDSSRLKQPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID44</accession>
    <name>A0A6P8ID44_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein M-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116299396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563912.1">
        <property type="nucleotide sequence ID" value="XM_031708052.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8ID44">
        <property type="interactions" value="2931"/>
    </dbReference>
    <dbReference type="GeneID" id="116299396"/>
    <dbReference type="KEGG" id="aten:116299396"/>
    <dbReference type="InParanoid" id="A0A6P8ID44"/>
    <dbReference type="OrthoDB" id="610462at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000362">
        <property type="entry name" value="GBP2p Poly(A+) RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000034">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein M isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="94"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="232"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="451"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563912.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="70267" checksum="C98C10CD94C5C3A3" modified="2020-12-02" version="1">MADQTTEHQLPLGMTYSTAYSLGIEATPTYTATNDTETREQREESKDSDQEESEGRRRGGFERDLRSDRENRRFTPYSTSRSKGRVSSSALKDYRVYVSNIPYNVRWQDLKDYMKKVGEVSFVEIFEDEKGRSKGCGVVEFREKEDAQKAITQYNGQDFQGRPLQVREDRVEEDSRMHRSRLRGNTIAQSSQQTTSNALQGLQGLPGLGGLPALLGLGNTGSMANKNDPSACTVFVSNLDFRVNWQKLKDAFKAAGNVVRANVKEDDNHKSKGYGTVQFETPTEAMNAVMLLNGQMIMDRTVTVRMDRNATQGGSRGSSQASVNPLAATGSQVAILNLLQSLQGLTALAQLGNLGGNLGNTNLGNLGNLGSTTANQSYGGMSAMPSTSSAGSASAMGMDTANLAALSNLSGMMNQLGSTTATSNYGTTNYGTTSYGMGVGGSTQSDSSSGKQIFVRNLPWKYTWQDLKDKFRAAGNVSRADILTETGGRSKGCGIVVFDTQEEAQRAIAMFNGVSFDGREIDVRLDRFGXVSCFTTIHTVYNFGXHSYTLCSWILLLMLILIHWHKKFSLNFQVFEIVAAYLVILDRGKERHEAGIGILQNTLGRCCDLFSLVFRDMLGKQFLWRSLVCWRSLLTRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDF9</accession>
    <name>A0A6P8IDF9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116299663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116299663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564227.1">
        <property type="nucleotide sequence ID" value="XM_031708367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IDF9"/>
    <dbReference type="GeneID" id="116299663"/>
    <dbReference type="KEGG" id="aten:116299663"/>
    <dbReference type="InParanoid" id="A0A6P8IDF9"/>
    <dbReference type="OrthoDB" id="10338358at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031564227.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16188" checksum="D14D597A0C7036B5" modified="2020-12-02" version="1">MSNLGCYGEFINELRFIVLQHMIIDNKLGVCTHPDLSRLEQVFHDKEEYLTKIAHWKDLEADDFAPCAAKMNRRCATELAKEFMSNKKLCSDVSHFMDCYKSAPCDDKIYKDFVQDLKMCKEIFIQKYAKDLRELSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEP9</accession>
    <name>A0A6P8IEP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide Y receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116299946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564535.1">
        <property type="nucleotide sequence ID" value="XM_031708675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEP9"/>
    <dbReference type="FunCoup" id="A0A6P8IEP9">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="GeneID" id="116299946"/>
    <dbReference type="KEGG" id="aten:116299946"/>
    <dbReference type="InParanoid" id="A0A6P8IEP9"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031564535.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42264" checksum="9A107CD7831AC322" modified="2020-12-02" version="1">MTGQGSTNFTSNTSAPDYIKEPLFLEVTRLTVEVSIAVLGVLGNVLVCHTVTSSKKLHSVANFHIRNLAIADLGVLLINFPLAVIKEQDPTNWPLGEFFCRYIYPIGDVFHGVSVWSITAIAIDRYRAIVGGIRRDRKRALKTARATVILIWLVSFLIVSLPLFFVIDFKDLRPLYEVVDCTPSWPDRLDKNIFHQTYMIGIAVFWYILPLSVIISTYIKIGQRLKESSQFHKAIRRSFSAKKRRRREQINAKAKKLLTPVVVTFAVTMFPLNALRLAITYWEELHWDRFIWVYYNITVICVIANSSVNCLIYALVSAEFRREFKKKFYGWHSPKQHFESVKSTSLLQSATTLQKNDLRAVKDRETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFA4</accession>
    <name>A0A6P8IFA4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116300641 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116300641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565404.1">
        <property type="nucleotide sequence ID" value="XM_031709544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFA4"/>
    <dbReference type="GeneID" id="116300641"/>
    <dbReference type="KEGG" id="aten:116300641"/>
    <dbReference type="InParanoid" id="A0A6P8IFA4"/>
    <dbReference type="OrthoDB" id="10055012at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031565404.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17650" checksum="0A2547D243D3EB80" modified="2020-12-02" version="1">MVIIKIVIFIATAFACFITTASRDYYRKGCYKDNWDRAIKGGVFKTFGWEDIASIDQCADIARSKGWKAFAVQYFGQCFTSPTAHLTYAKHGPSGICYKGIGNSFAMDVYFFGIEKNHESFSSHPSNYSTHFTHRRKIRLEVRQDQGRARLCTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFJ4</accession>
    <name>A0A6P8IFJ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tenascin-R-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565515.1">
        <property type="nucleotide sequence ID" value="XM_031709655.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFJ4">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="GeneID" id="116300732"/>
    <dbReference type="InParanoid" id="A0A6P8IFJ4"/>
    <dbReference type="OrthoDB" id="5971146at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565515.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20114" checksum="0C4CF03629EA9299" modified="2020-12-02" version="1">MKQLLCECGRVEVRYLDFYRSWADYKNGFGDLKGEFWLGLDKINRLTHQTRNRLRVDLQDIKGNSAYAEYDYFAVSSERSKYKLSLGTYSGTAGVSLSYHRGMAFTTKDRDNDVHGSNCAVLSKGAWWYKSCHYSNLNGLYHHGKVRSDGVIWYHWKNKYNSAXRAEMKIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG40</accession>
    <name>A0A6P8IG40_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031565648.1">
        <property type="nucleotide sequence ID" value="XM_031709788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG40"/>
    <dbReference type="FunCoup" id="A0A6P8IG40">
        <property type="interactions" value="2941"/>
    </dbReference>
    <dbReference type="GeneID" id="116300827"/>
    <dbReference type="KEGG" id="aten:116300827"/>
    <dbReference type="InParanoid" id="A0A6P8IG40"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000017">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="198"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565648.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="56442" checksum="37F44DDD15BA38A8" modified="2020-12-02" version="1">MADDNDCQDGKEFNGEISPIQEAEQLKTQANNLFKDGKYEAAIGLYSMAIELNPSVPAYLGNRSFCYLKTEYYGLALADANKAIQLDKKYIKGYYRRATANMALGKFKLSLKDYEMVVKFRPNDKDAKAKYTECKKIVQRQMFEKAIAAEEKAVFDTIDIDSIVVEDSYDGPVIDDKQGYTLDFIKQMMETFKEQKKIHRKFAYKILKDMKLFLEKQPSLINIKIPKSGKFTVCGDIHGQFYDLLNIFELNGIPSEDNPYLFNGDFVDRGSFSCEVIFTLFCFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKTKYTPEMVDLFTEVYNWLPLCHLIENKVLVMHGGLFSSDNVKLDDLREISRNKQPPSEGLMCDLLWSDPQPQPGRSTSKRGVGIQFGPDITEKFCKDNDLEYIIRSHEVKPEGYEVMHGGKCITIFSAPNYCDQMGNKGAFITMGRDLKPVFTTYDAVPHPDVKPMAYSNSLMQMFGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGC9</accession>
    <name>A0A6P8IGC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xenotropic and polytropic retrovirus receptor 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565789.1">
        <property type="nucleotide sequence ID" value="XM_031709929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGC9"/>
    <dbReference type="FunCoup" id="A0A6P8IGC9">
        <property type="interactions" value="1967"/>
    </dbReference>
    <dbReference type="GeneID" id="116300949"/>
    <dbReference type="KEGG" id="aten:116300949"/>
    <dbReference type="InParanoid" id="A0A6P8IGC9"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14477">
        <property type="entry name" value="SPX_XPR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="430"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565789.1"/>
        </source>
    </evidence>
    <sequence length="681" mass="79457" checksum="EEF174C184521CCD" modified="2020-12-02" version="1">MKFTEHLGTHLTPEWRVQYIQYEKLKEVLYAAFEKMPPKDETAEAVVQRFFNKFQDEWFQYCDEELSKINTFFAEKIAEAERKFTALKSELYVTESLIKEGSSLKNLRTGSKLTLATKPDKKKVKIKAKTINDLKLAFSEFYLSLVLIQNYQQLNFTGFRKILKKHDKIFDTTNGVQYRQTKVETANFYTNKTVDDIILEVENLFITELEQGNRSKAMNRLRVPPLGKELSGDLVTFRVGLYFGVFLMLSLVNVIAAFYTKTKGDLEVAIRIYRGIFLIVLVTFLLALNTWGWRKAGVNHVLIFELDPRHHLSYHQLLEVSGLLAVLWSLSLTAHIFGDVVGIPHFIPNLVLVSFIVLFTFNPFKICYYKARLWIIKVLFRIITAPFQHVGFADFWLADQLNSLVVALLDFQYIICFYSHDWHVDSKERICDTNLYGLRPLVACLPAWFRFAQCLRRYKDTRDVFPHLVNAGKYSTSFFVVAFSTLAKSNSPESDKFFLLWIVAAIISTCYTLTWDIKMDWGLLDKKAPVENKFLREETVYRYKACYYLAMLEDFIFRFLWTLTVSVGDLELFHSEILKLVLALCEVFRRFVWNFFRLENEHLNNCGQFRAVRDISFMPKDTHHQAQIEDIMDDENGLGPDSKRKRKASIMIKSITTNKRSSPTNEIIIENDTARDLDTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGW3</accession>
    <name>A0A6P8IGW3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565964.1">
        <property type="nucleotide sequence ID" value="XM_031710104.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301100"/>
    <dbReference type="KEGG" id="aten:116301100"/>
    <dbReference type="InParanoid" id="A0A6P8IGW3"/>
    <dbReference type="OrthoDB" id="6262482at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF335">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="76"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565964.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25789" checksum="339A7530932F182F" modified="2020-12-02" version="1">MCRPDFSWDTFTCDVDGGWAPWTTWTTCQSHPASCPRTRNRTCSNPPPLNXGAYCIGLGLESETCVGNVNASQRECEIPLGMEDGNITDSQITASSTYPSSITLDPWQARLKNPGIAGVTYGSWAARIRSVGQHLQVDLRCPKMITRIATQGRSLGADQYVTKYSVSXSNDATSWIQYLQDGAIKVFPANNDKQTIVKNSLPQPLIARYIRIIVEEFHSWPTMRMELYGCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK75</accession>
    <name>A0A6P8IK75_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTI1-like tyrosine-protein kinase At3g15890 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116301840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566838.1">
        <property type="nucleotide sequence ID" value="XM_031710978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301840"/>
    <dbReference type="KEGG" id="aten:116301840"/>
    <dbReference type="InParanoid" id="A0A6P8IK75"/>
    <dbReference type="OrthoDB" id="6349622at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047117">
        <property type="entry name" value="PERK1-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47982">
        <property type="entry name" value="PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="184"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031566838.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48593" checksum="AB1DCBBF8B4171A0" modified="2020-12-02" version="1">MMATYVTAPSEGSSSGSPKFASTPTSNISTTPNTSRSASPTGTLILDSDNDEIEDDSDKKETSKSPPETPKSAKQKPKRIISPGETRRRNARRKKQKALKRKLKQDARMNSFTYMSKACKTLEAKNSDIQKSFNATVVQMKAVHKKYETLKGLLDNVQSENQSIKSTFFKSIRTDQLXYIKDEFGSELILGKGRFGICKLMQLQIGGESLKVAAKHYVXDTSEEIVFKEAQLLLQLSHEAFPYLFGVTLLNSNHVLVLEFCPTAEGKRHSLTMHQMLQLKNTAIPVLDWLKLLMKCANGYAYLHSKGIIHNDIKADNVLVIQDKYGSSHPKIIDLNKAEHIEQLRHSSKREMSTSEREKRKLMYPHTDPAIYDGFYLPCKESDVYSFGYLTKHVAKVTRSELISRLSTSCMSRYRRPTFATIKQDILSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILJ0</accession>
    <name>A0A6P8ILJ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567642.1">
        <property type="nucleotide sequence ID" value="XM_031711782.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116302482"/>
    <dbReference type="InParanoid" id="A0A6P8ILJ0"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2042"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3459"/>
            <end position="3484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="847"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2420"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2725"/>
            <end position="3237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3283"/>
            <end position="3399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2042"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3459"/>
            <end position="3468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3469"/>
            <end position="3483"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567642.1"/>
        </source>
    </evidence>
    <sequence length="3603" mass="421809" checksum="91D2BADFCA0C6379" modified="2020-12-02" version="1">MSKNTVXQESSGSSFQMYQSGISDARSKDTLSDDTVAYTRVQRTSRGLYDDSDLTLKRYDSAKDTFIDLEAAYKRFQLQLQTERDSHKLEVGKLTSRIDSLTEQNRKLNEQISTFKYDCKKHQEELMAAQRKLRDKDWEIESLKRDLGFRENTIEKIRSEKVALELELNTLRDEMSMQVMQAPVVESAVDETEFYLLRDQVSQWESDYNLIVDERDTLLNDLSVLQAKVSGLESDVDKYKRQAQSSGKNETQIISKYEVQIQNFNKKRDILRGQYDNLKEELKRCRETIARMEAEAMENQVITNKLKEDNSMKAHKIDNLNATNAELQDKLDKLRAQLSKTEAELEFLRRQSSTREDMFKSYEKKLHDLEETLARLQSERDAFESDLTVANMKVDEFEKSNLKWRDRVHEWESVEVMLKKQIGDLTSELETTKEKLSEQVDGEVINRLRELQSQLDASVTTINDLRSEYDLIIRERNDLRKEFDGLTTKMSGLQETIRLRETEKTGLERLVTDYKNKLSRLESQIQTLTNLRDKLKKDLESEKARSGEIKKDLLRVENELAEARRNADRLKAEIAKNKKTIEELKSKIATLEDKVDSYREEAENLEKKIEFLEREKEDLHDQLLEMQKHLQDVESNYRVVSTERDRINSELQSCYKQIADLQSKYNVCEEQKNDYEQKVIMLTQKVGRLEDDLDKARRDNTVLEAEAKDLTTWKENATHEIDTLQKQLRDEKRLSESFQKEIEQRDTTIDDLKAKISKLTNENEALTDELTSLKALFKTIENENKGLQDKLDAANDEIARLTALYESTTQNKDQLVSEATVVQMKASEVESSYMDSVQREKDVAAQLEEERDKNRFLEMDIEELKKTVVNLNEQISVRQRDFDKLENDMDVAEEKIISLNLEIEKITNERALEYNRLISAEARLAEIEKELETTRSEKETAEKELYDLQTKTSKLETQLETSKKLVAQLREQLNNLNAQLLDYKERLMQIESKSVQSEKFSETLNSVISRKDKTIQELNNKNRVLQDELDKIKRQLNKANGDNETLAVLKEELQNKLKNAINKSRDLEDEIRGLKEKRNNLEHDLNSKDHEMQKLEMQIPPLKKERDQLKDEINSIRQDYKHVKETLLNAQNLINDRDRTNSTLNKQIKENLKIIENLKSSKAALGEEIANLKTELETVRYNSQEKIRELQDKLNSASLHVSKYETVLSTSVREKDLHQKERQDFESRNFELENLYRASQDREADLKNEVHALKAKLNQIDAEYKKSQKRIIELQHQVSQLERKVTDLEGANERVTRDKKDLKDSLVSANSKITELELKTEYDDKEIASLKKQLQDALNRSAASREELLRLEQQLIEMRLIADSAQEKLNEKDNIIHQLESSKNHLIDEIENYKLTVSATEKERDKLKEEIDQLKEDNIELSRSIQEIEGEMRRLTMERDRLKADYDSSVKKVSSLEEQIVILSRNEEGNKDKANELRNLLNSHRDERMTMEKNLNELQSKVDVYVVDLQKKDQAIEDLKNERDNLARDFDNMKKDFRRLEAEHDRLVKEKAEIEKNYKIIEEKYIFIENSFENGKSETNDLKDEVVGLRKRFQDIENANKLLNDKDKEMREKIATYESDISRLESTNQINNERIMELEHELKAANDELKPLYGDRDRAVHDHESITEELEQVKTYVKKLERQLDDTNKEKKALEVQLEESIGSIQSNETQLMNAERELQEVLMSKDNTDAADALETVKKERDALSRDVQTLREEITTMKSTLNTTLMKKDDLEKEAFTLRRQVADYMTKIKSLEQENEDLNRELIKNQKKLSDFEEQIHRLVTEKSNLKDELDDARSKLDKQKEINLNLERLIMELQSKVDAMERTIEDGNNQIEWYRNTQKTLEDEIVNLKKKLSTYRTESDRLSQDNTALNMKVHELESKIADLTHQVETLEGERNKLRQENISITTSMNEYKNNYNTAKKDVDRLQNEITSLNRKVVYLETRNNGLEVDKDRIKKELANVKKENAELSARIEALLGEKNRLQNEISVVQKKYTEIRTSYDDKRDKKKPDPNLQKKYNDLQDTYQKTLKDKEDAERKYLEISRQYSKLELEHGDCGRTIDSLNHDLSLKIKRIDELQDTLSLLQGKDVVDSGDYKNLRKKVVNLEQELQGANNKIYRLEAYKTSYEEKFQKMQEDLVAAQQRASQSDNTLQEAYEEINILKKDLMDLKKKNSDLETANQALNNAKNELRRTIQEYQNKITTLEDELQVELKQQAHLKGILEQTKMRNEKLKEDVTKLQKRLIDQQKYYEDQLKDLTEMRAIIGRLRDDNHSLENENETLKKELEMVRHEADEATQELREVKYDLQKLQIQYTELESTIRLLRDENEKLKIELESVKRLYDELRVTYEESVIIKSSNVEEVEAMPEMPEDYESMKLDNDRLTSENSALKGKIDSFENTINVLKEERKKLQDKILELQKAASDKALELQTMSGDKNKLTVTVETLERKIADMKQEEDELLEEREALLKELDTMERKLHDLVIESQKSKQAEVSSEQIFSVIEADYKKLQEREAELQVELLEALKKVSQLEHDVKAERDRSSGATDSNKLLEDQVATLRKEIVTYQEKMSRVEADREIGQGKVKDLQSEISELEDKIKDLKKSNELTQRGKTDLENEIIFLRNKMKKLEITIDDERKAKESLKTQLEDYRKKGDDQSKDFGTRVTEIQMEMETYRTEIAEKDRVISTLQAKQVDLESDISKLKRDLSNQRLECTEHTRDLENANKERSELEVQVNGLRGQVRNFQLLIEEGGKDKSELSVQLEDFKRKNENVKREHTTQVSELKVQIEDYRKDIGAKERKIKEVSEKLHTVEHELTTVKKELVKKEEDNVHLAKAVEESKRYRTELEIEVGSLKNQVATLEVKIESAKKEVSSLQIQLVETKTHGEKDSEQHVTFVSELQTNLEGVKKEVVTKEEEIEHLKSENELVRRDLYTKQAECSSTIEKIEKIQNEKTELTIQIMDLREKVIFLESEVQKERIEKESFQQSVVDMKRKGDTDSEAMSRELTDVSTRLESLKKEVVEKDTVIEKLKFHNNDYEKENAKLKRDFSNKKNECEGYIREIEKLNNEKSEEEIVIEQLKSKVNKLERQLEDLRRDKEIVVTQVEDLRSRGDSETSVLNEQITEIQTRVEEYRTEIIEKETVIERLRMMVSNNDAELDRLRRELETKEAECEGYIKEIERLNQERYDLQAEISTVRNEYNIIIKQLEESKADNELTEGETALLNDKLSEIETRVETYKTEIIEKETLIERLRILNNSNEQEVEKLKRDYENCMTECKGYIAEIQKLNNEKADLDVELNHRNSMVVKLEGQIENYKKNNDSQYKEIITTLESDIEKLKRQIKTQSDECEGYIKEIEILNQEIFRLKGLIDTDPNRYHTEFVIGQKEKKVEHQVIVKEPSVSTTEVSRYEMSPKKLVTVRSPFERKDEDQGSSHVSSKYTRIQRSGSPMIKVKVDPSEETTTATATSDNGQKVYTKKVVKTYRSESPGAMKVRIDSPTTTVTEVRSGSAFQEIAPHKITVDSDGSSKYSFEPVRDGRSSAETVTKITKVKKSYTKGSSLGRDSAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILM1</accession>
    <name>A0A6P8ILM1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302527</name>
        <name evidence="16" type="synonym">MCM7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="RefSeq" id="XP_031567709.1">
        <property type="nucleotide sequence ID" value="XM_031711849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILM1"/>
    <dbReference type="FunCoup" id="A0A6P8ILM1">
        <property type="interactions" value="2059"/>
    </dbReference>
    <dbReference type="GeneID" id="116302527"/>
    <dbReference type="KEGG" id="aten:116302527"/>
    <dbReference type="InParanoid" id="A0A6P8ILM1"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000007">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="331"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031567709.1"/>
        </source>
    </evidence>
    <sequence length="718" mass="80928" checksum="61583EAF4AC631B3" modified="2020-12-02" version="1">MTDYDSEKDKAKRFLAEFYYEGDEGKIFKYGEQLVKVAHREQVQLLIELDDIAEIDPSLADNVKENGRRYKKIFEDAVYEMLPDYKEHDVQVKDALDIYIEHRLLLEQRNRQNQAETVDLRSKYPPELLRRFEICFKHLSIQKPESVRRIKAESIGKLTVVRGIVTRTTEVKPVVEVATYTCDQCGAESYQPITSQTFMPMLMCPSEECKVNKAGGRLYLQSRGSKFVKFQELKVQEHSDQVPVGHIPRTMTIIAKGENTRLAVPGDHVCVTGIFLPMLMTGFRQMTQGLLSDTFLEAHRIVLMNKTEDDELGTEELSEEEVKALSEEADFYNKLASSLAPEIYGHEDIKKALLLLLVGGVDCTPHGMKIRGSINILLMGDPGVAKSQMLSYVDRLATRSQYTTGRGSSGVGLTAAVMKDPLTGEMVLEGGALVLADKGVCCIDEFDKMMDTDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPKKSAEQNIQLPAALLSRFDVLWLIQDKPDKENDLRLAQHITYVHQNSSHPPSEFEPLDMNLMRRYIAACKEKMPVIPEGLTDYLVSAYVEMRKDARTNHDTTFTSPRTLLAVLRLSTALARLRLADAVEKEDVNEAMRLIEMSKASLTDEEGTRRVVNPVDAIYGIIKEIAGDANSVKMQEAKQRCLSKGFTPDQFNSCLSEYEELNVWQINQGKTRITFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP50</accession>
    <name>A0A6P8IP50_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116303283 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568659.1">
        <property type="nucleotide sequence ID" value="XM_031712799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP50"/>
    <dbReference type="GeneID" id="116303283"/>
    <dbReference type="KEGG" id="aten:116303283"/>
    <dbReference type="InParanoid" id="A0A6P8IP50"/>
    <dbReference type="OrthoDB" id="10285403at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028012514" evidence="2">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568659.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22387" checksum="910DFC5F0450A2C0" modified="2020-12-02" version="1">MHPKCIPLAVLLVTSCFAAYIVVVNGACSEADQANEVQKCEKTFVDTMIKNSSANCTVEVGKIHQCLEKLSKSCYPQVNDKVIKQIVSIGMTQIQALQFYCMETKLNYTWSNVAPSVKNQLSSCAVSFDETANQCSKDFRLKMQKTPKDSAAVYRSYEDSNKCIQRAASKCPTSSGTTKTTTAFWFNATLLLIASIANIIKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRJ4</accession>
    <name>A0A6P8IRJ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116303566 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116303566</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568989.1">
        <property type="nucleotide sequence ID" value="XM_031713129.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031568990.1">
        <property type="nucleotide sequence ID" value="XM_031713130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRJ4"/>
    <dbReference type="GeneID" id="116303566"/>
    <dbReference type="KEGG" id="aten:116303566"/>
    <dbReference type="OrthoDB" id="5949679at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40743">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40743:SF1">
        <property type="entry name" value="POSSIBLE GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031568989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568990.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="36570" checksum="E7688DE4769446E2" modified="2020-12-02" version="1">MKKGFFARIPVLLFVICLVLMLYITRMFWKTIDNKIADVHRQQGHQTNSSHSLALVKTDTILRGVKGTRPTSNIGFLHLVIQFPLLSNASSNDTAFVRERQLEYIQTLQINLAHPLVKRVHILCEDDQAMRFIKHHFKLNAQKIILKNIGHQLLYSDSLAYVSKQLLFETCIIMHADIYIGKGFERLDPNILKQGTIYALTRHEDREQMKACPGLEDFCDTPFRGSHDAFVMHLVRPLPDEVLSKMNYRPNLAGAENVFIYMLETYGHFRFKNPCSILYIIHNQCRTGRDMKHRLVEGQRLESYLKVPGRSAGFSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS52</accession>
    <name>A0A6P8IS52_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116303718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031569165.1">
        <property type="nucleotide sequence ID" value="XM_031713305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS52"/>
    <dbReference type="GeneID" id="116303718"/>
    <dbReference type="KEGG" id="aten:116303718"/>
    <dbReference type="InParanoid" id="A0A6P8IS52"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569165.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24942" checksum="1FA92E22F864A63C" modified="2020-12-02" version="1">MCQPNSPTSSEGRFLVIGSKGVGKSAVTVRYLTKRYIGEYQSTAELTYTQTLKLDEDVKGSTFEIRDTLERGNISLYESSIRWADGFLVVYSITDRNSFNNAIQLVEAVYDGKGTDEVHVALIGNKTDLEHFRIVTKEEGKSAAAQLGCMFFEISAAENYENVQVALNSLFRKVTIHKKLMMNGKAKRKTSSSEKKKYGFGNGLFKRKNERKSVQRKFDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT64</accession>
    <name>A0A6P8IT64_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC116303960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116303960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569460.1">
        <property type="nucleotide sequence ID" value="XM_031713600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303960"/>
    <dbReference type="KEGG" id="aten:116303960"/>
    <dbReference type="InParanoid" id="A0A6P8IT64"/>
    <dbReference type="OrthoDB" id="98591at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028244045" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="13">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="13">
        <location>
            <begin position="278"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="13">
        <location>
            <begin position="502"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="13">
        <location>
            <begin position="617"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="13">
        <location>
            <begin position="729"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="13">
        <location>
            <begin position="841"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="13">
        <location>
            <begin position="1189"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="13">
        <location>
            <begin position="1306"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1549"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1553"/>
            <end position="1577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031569460.1"/>
        </source>
    </evidence>
    <sequence length="1577" mass="171330" checksum="F7D7805173BF297A" modified="2020-12-02" version="1">MVCKLGFVFVVLISVGSTLGWPWRSDPAQQEHLTRQKRSVECKNHLDCFQCDQKKRQGQCAAYLSVCQHTCNPDCASTPFADEPYKPCADIKAQGDCLKAMPYSSSLWLSVCEKSCCVLENPPKWSEWSDWGSCSKSCDHGFKTRTRVCQGEGFGQTCEGSPFESAKCNVGVPCKGTVGWKDITTTVEETVGKVTLTIVRTVKTDCDASIKVNTKDGTAVQPDDYVKIEDLVIDFATDETEKTVTFTINKDKLIEPLESFTAVITADPNKLNVDPAVTTINIKDCTAKIGLRPDKYEVQENLKIVKVTVFREGCLRDTNKVCISTVDGTAKAVSDYVAISKQEVSFAPTETSKEISITIVNDGVEEQDEDFSVELGCADPATLIVAPGKATVVVKDDDVDGNWSDWGPYGDCSKTCGSGVQTRSRTCTNPKPQGGGKDCEGLAVSSQACNTHKCPINGSWSEWGPWSEGTRTCGGATRYRTRTCTNPPPQYGGLDCEGPEKETQGCNNEPCPAQVGLKPKEISVLENVGKVEITVFRVGNSIGSNKCKLNTVAGSAEAGKDFDAIADLDVIFEVGEETKTVSVNIIDDKELEESENFQVKLSCSEDPSVTEVNPDTTTITITDDDVQIGFDPTSYSVRETDGQVTLKVFRKGYLKEPNTAIVNTCDLTAKAPEDFTALADFEVSFAAGETSKDVVVSIVDDKVLEDVETFCATLSTEDPKVSKVDPAKAEISIVDNDVKVGFRPDAYEIVESKPYVIVKVYRVGNLKGVTKVILNTIPDSASEGSDFTPLEDVVVTFLAGESIQSFKVNIVDNNIVESLESFTVKMTTKDTDVTKILPDVATIKIIDDDAVFSIEQPQYCVLETAGSLTVKITRKGATTFEHNAILNTQDVSAIAPADYEKITDLGVKFGANELEKEVTVNIVDDNAEEGPEKFKLVLTTSDPRATVENGVAVINIEDNDIDGKYSEWSAWSACGKSCGQSSQSRTRVCDPAPQGGGAACSGPNTETKSCFVLEHCPVDGGFSDYAAWGDCSRSCGGGFQLKYRTCTNPAPQYGGKPCVGTLVEAQACNDKCCPVDGQWSYYGSWSECKDGKQSRTRKCNNPAPSCGGKDCEGGAGAATQTRDCPPPSPCVYESMLTLSNRELETGEFQSKDNEIRKSCKSGTQSRTRTCTNPAPANGGKKCVGDSSQSRVCNKNVPCPVSVRFHPLNYKVVESDVNDVTVKIVRSGDLQQATTVFLSTVDGTAKKLSDYRPRNKLPVKFKPGQKERKVRIDIINDKKVEKASENFFAKLTSDSPSVKIVPSGSKATIRIDDDDSVFRFKKIRYVVKENVGKVNLVILRSGATNKKQTARIQTKDGTAVSTANGDFQSVGNPTPLSVVFGPGEKHKTVSVKINDDKICEKRERFTVILSTKDNSATVNDKFDVAVVDILDNDVNGGWGKWSPWGKCDKPCGKGRKYRSRKCNNPAPQGGGRKCRGSPRQSAYCYVKRYCPINGGYGEWSKWSSCSRSCGAGSRTRTRVCNKPKPQYGGKPCDGVPKQTRKCYLRACPYAGNTPTPPPYKPPETKPPAYQPPPPYNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU48</accession>
    <name>A0A6P8IU48_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium-coupled neutral amino acid transporter 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116304914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570569.1">
        <property type="nucleotide sequence ID" value="XM_031714709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IU48"/>
    <dbReference type="FunCoup" id="A0A6P8IU48">
        <property type="interactions" value="1144"/>
    </dbReference>
    <dbReference type="GeneID" id="116304914"/>
    <dbReference type="KEGG" id="aten:116304914"/>
    <dbReference type="InParanoid" id="A0A6P8IU48"/>
    <dbReference type="OrthoDB" id="513400at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="7"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031570569.1"/>
        </source>
    </evidence>
    <sequence length="729" mass="79600" checksum="26147D79DF4FFC4A" modified="2020-12-02" version="1">MAPHRPTLFNLMNSIIGVSVLSIPYCFHQCGILLGPLAMITMGYFTRKTCYFLLISSQLGRRRSYESLAQFTYGNAGKFAVEACIIGVMAGTLCAFHVIIGDLAPDLFSHLFGIQQTPTLRALLMIVLALCIGLPLSLMRDISSLSSISATSLGFYATFVLYVMFSSLPHLLEGTWTKHLNFWRPAGLLQCLPIFSLAFSCQTQLFGLYDSLPEPSVKKMENVVSVGIKIISCVYLCVGLFGYVTFYDVGVQGDILTNYGSGSLGKFLKMGFVMSVLVSIPLMVFPMRASINSLLFRSQTAGTENMPGGPGYMPQNRFVIITVVVICATLNVGIFIPQIEFVLGITGATIGTLIILVLPASMYLNAIQDTQGEQKNMAKFTIVFGLICLVASTYSVLSVNNHSHHESSHPLPSTIKPAILVNTLPNTSDPVVGPIQAVKANGVKADVGLRNKEVKEANPTQKPAESKTEKPSEGKRKIEEIREKAAQRKEPALPHPPADKPAEGPIKKNEKEADPVNEKRQLMSTDDANQSPADTQEDKDLSSKLDVPQKSALKAPISKTESTNQDIEKKIKNLREKKAQVESDLKSLQELKKPENRERRDLEKKRDGKEESTVVDPTDKEIPAHTVPPNDTNIRIVGPNSSSMPLLNPTTIGKTPAEVTNPAIVANVSGEVAKGRELKSNGVVGRTLKSEDKLVNNNDSKVGNTGGYRNLWGTRLARRANRLRKTGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUL7</accession>
    <name>A0A6P8IUL7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline-rich transmembrane protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116305050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570744.1">
        <property type="nucleotide sequence ID" value="XM_031714884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUL7"/>
    <dbReference type="FunCoup" id="A0A6P8IUL7">
        <property type="interactions" value="984"/>
    </dbReference>
    <dbReference type="GeneID" id="116305050"/>
    <dbReference type="KEGG" id="aten:116305050"/>
    <dbReference type="InParanoid" id="A0A6P8IUL7"/>
    <dbReference type="OrthoDB" id="5987581at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF25">
        <property type="entry name" value="DUF4190 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031570744.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="10893" checksum="855B9792F234E628" modified="2020-12-02" version="1">MVVARPVGVPPPDYQALAWFACLCCCWPLGLVAIIRSNEVRTASARGDYLTAEAASRSARTMSFLAIGLGIAFMVLYIIILTVYLIPLLTMENTYNDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUV5</accession>
    <name>A0A6P8IUV5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571091.1">
        <property type="nucleotide sequence ID" value="XM_031715231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305336"/>
    <dbReference type="KEGG" id="aten:116305336"/>
    <dbReference type="InParanoid" id="A0A6P8IUV5"/>
    <dbReference type="OrthoDB" id="5972520at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
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        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571091.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50382" checksum="8035CE0A6C1A4155" modified="2020-12-02" version="1">MAAPALSRDSSVLKPVQDNVNLSSSSSTTTKRLTMVERAXLEALAAFGNEGLDSLSFKKTDLSSKLKSVTPSVNSKTANTRTLTRMEKARIEAATAFENVKLGQMVKNPRKRKMQNDANQHENSKKQNLTRIQKAKQEAEKAFENISLDKIPPKRSKLEKEKMEKRILEGKKESKPSDIKKAGRFKSHLPGTKSILKPSRASEKDSVVTEIRSTGDTTTPKRLTRSQSEKMEALKCGNGTQVEVSGRDALCEENVDQKLSQNHEKFIVNAGIAMETTADNVSNITPKSYQANSIDDNHGKNVAQKKLTRLEKAKLEALQSFAGQEFSNICKQSTRIFAKHLKPKKDQSCNTENEELLHNPKHVPEPHNQDKLKPQENSKLQVAVLKVSEMAKTSPQVLRQPKQKTPKVDFYSSVIEENFKNQSSLLETSRRVVKTAMELETPEGSPMSAMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUZ2</accession>
    <name>A0A6P8IUZ2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM and SH3 domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569973.1">
        <property type="nucleotide sequence ID" value="XM_031714113.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IUZ2">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="GeneID" id="116304387"/>
    <dbReference type="KEGG" id="aten:116304387"/>
    <dbReference type="InParanoid" id="A0A6P8IUZ2"/>
    <dbReference type="OrthoDB" id="5990560at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09527">
        <property type="entry name" value="SAM_Samd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058666">
        <property type="entry name" value="SASH1/NUB1_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF8">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26285">
        <property type="entry name" value="SASH1_Homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569973.1"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123451" checksum="C67BF0DB9952DD93" modified="2020-12-02" version="1">MSSTVEDWLRSLGLIQYTQAFLDNGYDELDICKEIGEEDLDAIGVKNDKDRVDILGAVRRLKQSGTAVYFVLEENSQTIVPTQKRENLIPLKLKLLLRDNLTEDNIDLTKEPYTLSNGACGNLDSLVTLYADKFYTYEQDVLEALENIRARQVGDLKSQIEGNQEEGDESYDXVESKPSKNHKHKRSNTSPLHAHTKENHKWHISSSSLNAKGXIPADYLDVDSPSSPHKNGKRRRPVERNSKLSRSLDSLKELHVNSAELKTKDKDQQTTKPKHTSSIFGLFRSSKRKSPGHEDKSHDTKSLNNDMYVTKPIAGSDLPASNITMGEEDRVTLMLMVKQGELTVEEAVEQLERYEKENKENQAAKKEMRRSGSCSEEDSSNAKPHKLKRNIFGRSTKKKSSSRPASEISAFDMTMSEEDRINLMKAVRDHEITIEEAIQKLASFEEESPSHKSKDNKHKFSPKSPHSFSRLSIKRVSGAFASAVKSGHHKEEKTAVFYTPTEGAVNTSSEGCSEDDNNWRSDSSPDXSPAGHRKVMHNLIRNAKQIHSTSSLHSSSSSSDAVDRLGTIEDLESQDSTPRRGSQQSPKKRIVDEMKNILSQREQEETTKEKGVLPSPGTSPIHXSTLPRNIKPTQTSLTRKSSLPITPAKPVPPIHALRKAPPPPPRPLPRQSTVPLIGLQGSSPDIDTKSELDKTTTPKPPKCPPRRKSLGENSKTEKADAKLTSEQRCLSPXLPPAPCPSSKQEDXGTSAGSETKSNRMSLEDDVFPPPPPEHLLTSLKPVSRTGGDSKHIIKPPRPSLLKGDTSRSNNETSELTVLLKQRNIIKEKAHSEARKPEEXVSKEQDASPARTGSSAQTGSPAQRGSPGHNGYPGHTGSPGHTGSPGHTGSLGQAGHPGPPVTKPKPAVKRKPQLPPKPPKLTPGGALKKAEEDGEEKQESTTRGVDHHSNLNVVQVPXKRPSHSLSDLIERRLRIEQIDLTELPYSSQDGKWDVPVNLIDRYTEEMRRSQKEVVEIMDRIRCLKLKEQHRPAIPCDSSLYPQEPDHLGKLGSVKEWLVSLGLPMYLDNLREVEYDDMANMPFLKQKHFEFAGVVDLRHMRRLLASVERMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWI9</accession>
    <name>A0A6P8IWI9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116305617</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571422.1">
        <property type="nucleotide sequence ID" value="XM_031715562.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305617"/>
    <dbReference type="KEGG" id="aten:116305617"/>
    <dbReference type="InParanoid" id="A0A6P8IWI9"/>
    <dbReference type="OrthoDB" id="5966936at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="2">
        <location>
            <begin position="198"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571422.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="29442" checksum="03A7BF2752214755" modified="2020-12-02" version="1">MDQESINTFSKLLDEKLSPIISDLCELKAKVSKLEEFERSLDFLSKKYDEFDTKMKKIELENHQIKMENTCLSTQLHRLSNELSQIKEECNNLGQYSRRDCLEIRGIPVSDDEDTSEIVXKIGDLVDVNIEVDDISVSHRLAGQKNKNYDPAIIVKFVRRELRDELYQARKYLRDKSTRDIGLVRFPTQKIYLAESLTRHNQMLFNRCLKARRELKYKYIWTNNGRISLRKDGSSPVVTISNDLDIDNLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX95</accession>
    <name>A0A6P8IX95_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lamin-A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116306100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571996.1">
        <property type="nucleotide sequence ID" value="XM_031716136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IX95"/>
    <dbReference type="FunCoup" id="A0A6P8IX95">
        <property type="interactions" value="2682"/>
    </dbReference>
    <dbReference type="GeneID" id="116306100"/>
    <dbReference type="KEGG" id="aten:116306100"/>
    <dbReference type="InParanoid" id="A0A6P8IX95"/>
    <dbReference type="OrthoDB" id="102442at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036149">
        <property type="entry name" value="APC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58050">
        <property type="entry name" value="N-terminal coiled coil domain from apc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="9">
        <location>
            <begin position="36"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="8">
        <location>
            <begin position="428"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="250"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031571996.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="65329" checksum="BF6E6C815C7574AE" modified="2020-12-02" version="1">MATAMKSPASSSSQTPEQSRSRFEGISPTRITRNQEKLELQHLNDRLATYIDRMRNLEEQNSMLRSEVTTTKETVEKEVDNVKSMYEAELADARRLLDETAKDKAKQQIDSSKNSALATEYKAKYEKESAARKKADKELNDLKKQLADKENQLSKVNTEARNLEEVMRELQSECQELKDALESAKYALEQETLSRVDLENKLQSLKEELIFKKSVYDKELTEIRSQLKTVETKRTVIETDYENKYESVLMEKLQELREDYDLEGHKFKEETELLYSSKYEELKAQQEKDSSIIAKLREENRDLSSLVDTLRSDLNQELAKSKALSQRVSDLHDLRSQDKKKADEAIVLRETEITELRTNIDEALKDYEDLMGVKVALDMEIAAYRKLLEGEEYRLNITPPSSPVFGGTPGSGRSRRGAKRARTEETESTITTTTTAEGAIQIIESDPEGKFIKLFNSGDKDEPLGGWTIQRQVGKEDPVVYKFTPKYVLKGNSYVTVYASQGGGHHKPPAELVFKQQESWGSGNEVRTALINAGGEELATLTEEKVFEQYCKDTIDGQRRKREGELNKGCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX98</accession>
    <name>A0A6P8IX98_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116305922</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571784.1">
        <property type="nucleotide sequence ID" value="XM_031715924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IX98"/>
    <dbReference type="GeneID" id="116305922"/>
    <dbReference type="KEGG" id="aten:116305922"/>
    <dbReference type="InParanoid" id="A0A6P8IX98"/>
    <dbReference type="OrthoDB" id="10626547at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571784.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20937" checksum="F18638A7D4E32E65" modified="2020-12-02" version="1">MAAVTVWARILKLCTRRTHQDPEDLESGPQINPKENKEITIYEKRGRRPSGFGIVKINKDSIELIDESYLTEGVANHPSVAPPQPAVENAEEFEMGAFHRRASEKVSEKRKVIREATANERRGSLQDEIEFARSVILPSDVVKEQDEDAMHRRQQIKAQTSGRRTSLLEEIIVAKEVLGVANDVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXZ8</accession>
    <name>A0A6P8IXZ8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116306112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572017.1">
        <property type="nucleotide sequence ID" value="XM_031716157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXZ8"/>
    <dbReference type="FunCoup" id="A0A6P8IXZ8">
        <property type="interactions" value="2320"/>
    </dbReference>
    <dbReference type="GeneID" id="116306112"/>
    <dbReference type="KEGG" id="aten:116306112"/>
    <dbReference type="InParanoid" id="A0A6P8IXZ8"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="695"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031572017.1"/>
        </source>
    </evidence>
    <sequence length="1033" mass="116289" checksum="9120E44C0342857D" modified="2020-12-02" version="1">MASPRSPRSPTSSSSSPRQDSSKSSQSISWDAEIDVNTLFVEHSIEEIRALEKKTRGDIEKKKEELRLMVGERYRDLIDAADTITEMKDYTKKITTSVGDIQKQCKELHQSHRCYGVGGSPSVKPTSGSPHSKNGFYSLAAQMKLLVDTPEKIWSALERQQYLKATQLYLLSHHIVSILHLNSGSGAAPRVLSSFPILQRQWAAISHFKDSIIQGSRALLKDATQTDEMTAEALCSILLLEESSPRQVFSEFLLARKSSLQEIFHPSQHSTSIKSQVCELIRVMRTSLYQIHSIFICDVENTEEIHDVKDNPAMLFQTLNRVTKRDKSDPNIDEEVLEALFGPDFDLVTSARYLPKTVLEYRPHIRAFPATIPLPNIQGNCEEWIGMCLKDISSGVGKLLTYVGTLKGLASMRDAIWELLKECDSNAQFTQDNEVVELEWNQLCTKVINHELSLWDKFMRPLFVNRAKAILSGLLDATVVSCQNMIIQSQDDLSVDIAQDTNALWERDISRYVWHESVNDVPLASLWGNQSGDTKKQSLDGDGLALKARGCTPAVQRLCVCINEKLQATSDDAQHFISKIKDTQSSEKSRVSISGRAEELGIIVGQTDKIDEKGPFDRFSDAKEIQTFLQDTCFDAFNRLLNNVDKSLTDHKKKLESCPSIYDTTSIDRVLFVGRLCHCMVEQCPQLKIVMRGAEPEEKPNARQSTPRLSRQSSLSKRKTEQTNDTKLKELAALIKNRYYSAFRLWKDWVCDIFVKSYEDSLLKGGTEAALFSMTSWEELKIQEESETGEKVQSTIRVPMQVSSFVTSLLFSLCQELNRIGAHALDRKILQELVDTLSDNILHLYEKLVEESETSLPQNRSLQCLFDFKFISAIFAGRSDEPIQESTESFSVRREAVIDSLEGVVDPFDLDVFSPYLAANLNRQLQRCGVLFGVLVSLDKHSNHSFGVTSRPSGSQDQHNIMPLAPNPPRFTLLPLSSHQSSLYGLSSGTRLSEPKKSSKSQMGQHSSLLGSTAFSRHDQFFNLKKNKEQTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZF1</accession>
    <name>A0A6P8IZF1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ homolog subfamily B member 14-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116306630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572569.1">
        <property type="nucleotide sequence ID" value="XM_031716709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZF1"/>
    <dbReference type="FunCoup" id="A0A6P8IZF1">
        <property type="interactions" value="2779"/>
    </dbReference>
    <dbReference type="GeneID" id="116306630"/>
    <dbReference type="KEGG" id="aten:116306630"/>
    <dbReference type="InParanoid" id="A0A6P8IZF1"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000137">
        <property type="entry name" value="DnaJ homolog subfamily B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031572569.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="43450" checksum="28C16A5F2A8BB0C6" modified="2020-12-02" version="1">MEGNKDEALKCRHLAEKYLQQGDTDKAIKFLKKAEKLYPSKKVQDLLNSLLKKESSEETEESEKIDGVRHRKQTSSHGETANGSVTYDKNYTTEQVEAVKRIKNCRDYYEILGIPRDASDADIKKQYRKLALQFHPDKNRAPGATEAFKAIGNAFAVLTDEDKKKRYDRYGDENPQNLYTHNHYDYSRGFEADITPEEIFNMFFGGPMPGGRVYVNRRHRNRNHHHSHVHDEGQEVNQTLYSLVQFLPILLLVLMSLLSTFMLQDPIYSLQRTGSYYLERQTNRYKINYYVQEGFDEKYSEAKSLHKLERHIENEYINRVQSQCYRERQYREELYARGRFWHEPSLIEKANNFKMRNCEALEKLSERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0F0</accession>
    <name>A0A6P8J0F0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand calcium-binding domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031572947.1">
        <property type="nucleotide sequence ID" value="XM_031717087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0F0"/>
    <dbReference type="GeneID" id="116306946"/>
    <dbReference type="KEGG" id="aten:116306946"/>
    <dbReference type="InParanoid" id="A0A6P8J0F0"/>
    <dbReference type="OrthoDB" id="6067987at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027814513" evidence="3">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572947.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19601" checksum="E8189E6C71280360" modified="2020-12-02" version="1">MNLKVIFILCLVAVLLFPDAEGWWRRRRSSRRRQSCNWHCYPKCHGYECKYKNGAISCYKLCKTVCSTVCSGKREVPAEEVPGDEEDPAKKPSSRKMKLIPLPLPDKFSDYDSNNDGQISYEEFKKALPHVKDNTAIRKGFHFIDRNGDSHIDCKEFLKSQLNAHKAEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0W1</accession>
    <name>A0A6P8J0W1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116307133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573147.1">
        <property type="nucleotide sequence ID" value="XM_031717287.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J0W1">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="GeneID" id="116307133"/>
    <dbReference type="KEGG" id="aten:116307133"/>
    <dbReference type="InParanoid" id="A0A6P8J0W1"/>
    <dbReference type="OrthoDB" id="5983039at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="472"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1243"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1280"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031573147.1"/>
        </source>
    </evidence>
    <sequence length="1319" mass="149225" checksum="68076C0B40B7813F" modified="2020-12-02" version="1">MASFGKIEQFNGQEAEFEEYVERLEQYFEANDLGELTLNGDGSNEADVEARLRKRRAIGPATYSALRNIISPSKPAEKTYEELVAVLRNRFAPTKSETVQRYKFHSRIRREGEKIADYVAVLRKTAETCNFGDSLHDMLRDRLVCGIKNEKIQNRLLVESDLTFAKAYKIAIAQETAAEEATALQDSLRPSLSVNRVQNKKDKAGDKPTTVSEKGNQKKCFKCGSKDHLAPKCQRPAHITCNYCKKKGHLERVCLSKYPKVAGVQTNLVNTQESPENSDSEPVENYKPLYHIDSPQDGSPIRVEVTLNDMPVSFQLDTGAGVSLMNYDDFKKYFNDAHLMPSSSKLRSYTGNPIGVCGERLVSVKIGNQYANLPLVIADGQDPPLLGRNWLLKLRLPWENIFSVLNPEPEPPQLSKLLQEHEELFKPGVGCLKDFEAHIELKESAQPVFCKSRALPFAMKKRVEEELNRLEKDEVIRKVQHSDWAAPVVPVVKPSGAIRLCGDYKSTVNKSAKMDRYPLPLVKEIFASLAGGQKFTKLDLSEAYHQIALDDATKKLTTINTHCGLYEYLCLPYGINSAVGIFQRAMENIMKGLPGVTVYMDDLLVTGKDDEEHLVNLKGALTRLLDNGLKLKESKCKYLLSEVEYLGYKVSSAGIQPTGSKVKAIKEAPRPTNVNELRSFIGLVNYYARFLPNLASSLAPLYDLLKKDVKWRWGSNHESTFRRIKEEMSEHALLAHYDQNAELLLACDASSTGVGAVLQQRTPDGDLKPVVFASRSLTPTERNYAQIEREALDHQPLVKLFGEHSGIPQLAAARIKRWAIILSAYSYQVKYIASKENVCADYLSRSPIQETPTEHEMEHEEVLSIDINALSGIPLRIVAIETSSDSCLSKVLQLTKEGWPNCCPNEELRPFFTKKDKFSVEQGCLLWSNRMIIPPVLRPNLLLDLHEEHMGTVRMKALARQHFWWPKLDTAIEAITKQCPCCQENAPKPTSPPVAAWNWPSGPWKRLHLDFAGPFMGRMFLIVVDSYSKWLEVLPMGSTTAQATLLQLRKLFATFGIPEHIVTDNGPQFTCGEFQEFMLRNNIKHTLTPPGHPASNGMAERYVQHFKSHMKKMKDNGSTLEENLARFLLSYRTTPHSATGDTPSHLLMKRQLRTRFSNLRPGLVSDKEQSVFEKNCKCEPRFKVGDAVFVLNLRSGPRWLPGTVIDVLQRSYYIQVDEHVYKRHEDQLRPRMLDMKVRPEADRNLEPLLQTPVPLETAATPVMGKTLKTSARAPFQPAESPHKEKEPSMSEVPKMEEEQPPGLRRNPERQRRPPLRYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J240</accession>
    <name>A0A6P8J240_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deubiquitinase DESI2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572173.1">
        <property type="nucleotide sequence ID" value="XM_031716313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J240"/>
    <dbReference type="FunCoup" id="A0A6P8J240">
        <property type="interactions" value="1340"/>
    </dbReference>
    <dbReference type="GeneID" id="116306289"/>
    <dbReference type="KEGG" id="aten:116306289"/>
    <dbReference type="InParanoid" id="A0A6P8J240"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572173.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21084" checksum="D46740A791DA02BD" modified="2020-12-02" version="1">MPQYPVFLNVYDMYWINSYTFNIGLGVFHSGVVIHGKEYAYGGHPYEWSGIFDMFPRSSDHLGPEFKFRESIKLGITEITEEELNDIVREMGARYTGVSYHLIDKNCNHFTSELSQVLCGKDIPGWVNRLANAGSYFPFLLKCLPKEWIRPEPESPTSPLFVNGSAFRELSGSDDEARIDNNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J425</accession>
    <name>A0A6P8J425_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116308130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574364.1">
        <property type="nucleotide sequence ID" value="XM_031718504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308130"/>
    <dbReference type="KEGG" id="aten:116308130"/>
    <dbReference type="InParanoid" id="A0A6P8J425"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35169">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35169:SF1">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027639996" evidence="1">
        <location>
            <begin position="25"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="356"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574364.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58376" checksum="2260423625DED211" modified="2020-12-02" version="1">MEIILPKFCLLFIVFFNITPXNHGRILDVVVWDDICTSKDLRSIXILLSSDQTEWYFNSVSPSTSNNSGISLGKTHYWTTKYDPISFSEKPIWNRIQQRLAQEIGVTADFLHVREVSAEISARGDNTLTXNSCSKTGSSQEEGFVVVIFAMLRKWDKNSYGELVVYDDDGEILKSIHPRNGRVVLFDCGYSYVIKPPSMDCKERFHTLTIRVLMSSDTSVAKLEFPPQPTLKQRYTSSRELIASLIDTSDLTTLDVEKHVTRQFRTTKGHPIIVFDDIIPKNLLDFFAEFIKNGSYGNDPPSPDSTDNVQWILALESEAVTESPLWKYVQAIVNYTSKKDQFYPYDVGCNNIRSHDTTKIHLDCAPDQEEYTILIYLNKNWTNNDLGETVFFNYGSEQPKVRNEMVFAIKPKYGRVAIFHGTIPHSARPPTPLYHGARYTIAIKMASSKAEAFQKTIELGIEPLETYLEKAQPEEREEVRKIIADIRNGKKSQVEMKQIVEKYEKMMEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5K4</accession>
    <name>A0A6P8J5K4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM214A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATOS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574977.1">
        <property type="nucleotide sequence ID" value="XM_031719117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5K4"/>
    <dbReference type="FunCoup" id="A0A6P8J5K4">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="GeneID" id="116308641"/>
    <dbReference type="KEGG" id="aten:116308641"/>
    <dbReference type="InParanoid" id="A0A6P8J5K4"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="3">
        <location>
            <begin position="621"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031574977.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="91999" checksum="C82EF4BA60DE9DC1" modified="2020-12-02" version="1">MKPLEVQTADVEEMECELHSKEFFVHVGMLVLEGRMPQQSDRGRIEGHHCGTSKGKVCHTCDDKNEECKEARTWTQIMEAHWQSTHPLVIDVLVKLNEQTDHLLLLEQWTVKIVCSACGPTSSGSQLLQAVRSHLHFSQLSAWLSSSKGILPYEIKYRINEQAEHQSYTFSREPTEHVFPLASLPSPYSLQVQVKSLPRCSIQELLKESQVVEEIFCNNSSDFSLLRSEPSSSSSSSWFSDTRSPLRKRTCLNKAENGQVFVAKEKATEVLSSDSQTRQRSYKTINLGKDFLKLESDGDWKRACLNEAGNGQVFVCKEKETETLFSESQAKSSTCTSRRSDKAINLEKEFLKLATSCDLKPCKSTENLQEESQIGKDSEFLNLGATPSNYEPIMDSNGTSNGISNLSERIKKLGRDIANIDRNVNTHAYQSEQRISGLSALLKEASKECTAEMKTDVSGAREKEKRTSREVAKMVLQRKCRSLSDRGVRVESLRNREPIQKEASRNTAEDRVCNKAKQSPTRQGTTSNSSDVDIHAIRQPVNRDCTYRRSVQLPFSACTEPVFNPKTGLPVSSSPAPLRRSTNELCEDTTDFSNGLSNKVDYRELSKLLSRSAPASTTQSLLVNFEESVLNGRMEPVGTVEGFVAELSTSGSFCPRHVKLPIISCFYRLSDDDAPSPYMGYISLKDDPIGRRGYHVPKKGTIQLTVFNPNMTVVKMFVVLYDCSDMPPRSQTFLRQKTYSALKGNEVKNEVQQNLHYLLHLRFASSKSGKIYLHTDIRVIFARQPPDLGNIYQLFTVTDGPTNPKYTKKHHSSEEPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5L7</accession>
    <name>A0A6P8J5L7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116307198 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116307198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573208.1">
        <property type="nucleotide sequence ID" value="XM_031717348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5L7"/>
    <dbReference type="GeneID" id="116307198"/>
    <dbReference type="KEGG" id="aten:116307198"/>
    <dbReference type="InParanoid" id="A0A6P8J5L7"/>
    <dbReference type="OrthoDB" id="5956362at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031573208.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="43053" checksum="4C5C9ACDE92B054C" modified="2020-12-02" version="1">MQNHYTQGKAYEGLIGSFNSFLGILANDIGKKIIMHFQNLGDNGMYQQFYVEQIKLLQGLKLLEEKFGEDYYKDLRLSVELEESIILFGQNKLDECENTAMRVFERSMNSPNGRFLMAKAHYIISAVFRQRGVFKRGEEHMEISTELLEAVEVCEETAVNQYNWAALLAEMSAKAPLSICEKEEAEYRFENTQLHWRNQAQNNTNRCPMRTRTREINYHLKTSRQRCPDMSQQVSEKALAKASRAIDYVELNLLNDCSKRHRVTFFIAKSDYHIRRTSMNGSVYTAEVIKGDAKTAALILESALAIAIELNLFKEIEGIEDRLRNINLLMETNWQSQNQPHSSRAIVPVEREDESIDGLLEELARRSLELTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5U5</accession>
    <name>A0A6P8J5U5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116309082</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116309082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575491.1">
        <property type="nucleotide sequence ID" value="XM_031719631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5U5"/>
    <dbReference type="GeneID" id="116309082"/>
    <dbReference type="KEGG" id="aten:116309082"/>
    <dbReference type="InParanoid" id="A0A6P8J5U5"/>
    <dbReference type="OrthoDB" id="5986656at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575491.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27033" checksum="A4ED9C763E6B33C4" modified="2020-12-02" version="1">MPLSESKRYARFNVGKMMKARKDQRNKVAMAHISLQENNRKLDSMGVKKRRLEDKIVEMKENIQSLSNEHQVLNQNPSAVVNRQNSPTCDDHGNNLRCNRTMNKRRSETFNSALRIHGGTSTNTLPAISGLVDTLAVKGSKGELTSVISRKRKLCNQVFPQIYNSSVKKFEDSQENLLRSISTYFTRGVIGKRKYRSLYRVLSMKKAKRKGKKLERIKIMSCKVARLLPYNKMIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J680</accession>
    <name>A0A6P8J680_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116308888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031575262.1">
        <property type="nucleotide sequence ID" value="XM_031719402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J680"/>
    <dbReference type="FunCoup" id="A0A6P8J680">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="GeneID" id="116308888"/>
    <dbReference type="KEGG" id="aten:116308888"/>
    <dbReference type="InParanoid" id="A0A6P8J680"/>
    <dbReference type="OrthoDB" id="6022067at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031575262.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38461" checksum="9018DA8642F75982" modified="2020-12-02" version="1">MILTKKNAFYAAIVVQALILLYLIIPSDKNHPILDFTRSSLAWFLNNNEDTSIVLNTTHACISLKPTIKHKPGEIFLVVLVISKALNEDAREAIRNTWGSKKETANDLVSYVIFVTGCTPSIHLDHEVDREASKYNDILRLGSQEDKDPHDIKRIWHGYRWAIKYQPKFIIKTHYHLYVHLPRIVQWLKDAEKPDKLYAGKVHNHVAVNRNPKKPFVVSEKEFSPANFPDYCAGPFYAFSGKLLKDLLDLERKIPKFNVEDAYLGVLMKKLEIEPTDIDSKLHIEGQLGNDVQSWTNQMYINANVIGMDLQPSSIQYIHDRYKGIERAALKREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J692</accession>
    <name>A0A6P8J692_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Octopamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116306866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572850.1">
        <property type="nucleotide sequence ID" value="XM_031716990.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J692">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="GeneID" id="116306866"/>
    <dbReference type="KEGG" id="aten:116306866"/>
    <dbReference type="InParanoid" id="A0A6P8J692"/>
    <dbReference type="OrthoDB" id="5949920at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031572850.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38823" checksum="67842C47C484DED3" modified="2020-12-02" version="1">MNVTGCLYFPVRSFEVTRLIVASSVSAISLNAIMIIVASIGNALVIMAIFKTRELRTTGNILILFLAVTDFLVGIVVQPLFMAFELATIHAKPPNCPVVVVYTVTRALCSILSLVTVLLVGLERSLAIFKPLKYSSLVSKRRIVSLVLGIWLFWTLIVMSRFIGVTTKIFRITVSSVIITCHFLTGCAYIRIERLASRHVKNIKAQMVSVANSANGRASKCKREKRALRTTTLIVGCILLCYIPIVGVLLANILARLEAQVSHVMFTWADSFAYLNSSLNPXIYCLRNAEFRRGIWSILRLRXKERDNQVALETTGRITRATTMENVATAMTGESPVLLQIXYLENTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCX5</accession>
    <name>A0A6P8JCX5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116309053</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031575443.1">
        <property type="nucleotide sequence ID" value="XM_031719583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JCX5"/>
    <dbReference type="FunCoup" id="A0A6P8JCX5">
        <property type="interactions" value="1268"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116309053"/>
    <dbReference type="InParanoid" id="A0A6P8JCX5"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="248"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="21">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031575443.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34771" checksum="CD3FF7BC4770ED3C" modified="2020-12-02" version="1">MFKGAGQPELIRSNQKDIYYLTSLRENFGQLFRDFFGVHSWMKYKDEIEVFAEVCYFGLTTLSGFQTLGEEYCNIVQVDDTRRAIPSTLNRCILVCLHTLAPYFLRKLLGKLEVLVQTPERWPSGWSEKSRIWLQESLPIIQQSILFLHRAHLTIFYLTGIFYHLSKRITSINYILVRSGLKNDSSRPTYRLLGYISAIQLSLSVLFTAYKSSRSVVSSDLAAQSSSSSCENTSNKIEPPGTSRRLKCPLCLELLHDVTATPCGHLFDWQCITEWCSEKPDCPLCREPVPLSRLVYLHCFEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JFS6</accession>
    <name>A0A6P8JFS6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 267</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116308804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575160.1">
        <property type="nucleotide sequence ID" value="XM_031719300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JFS6"/>
    <dbReference type="FunCoup" id="A0A6P8JFS6">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="GeneID" id="116308804"/>
    <dbReference type="KEGG" id="aten:116308804"/>
    <dbReference type="InParanoid" id="A0A6P8JFS6"/>
    <dbReference type="OrthoDB" id="10014558at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026572">
        <property type="entry name" value="TMEM267"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13628">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13628:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031575160.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26447" checksum="B5150620621E866E" modified="2020-12-02" version="1">MLSFAIKGFQRLSGCLWRSIFTMWDAITYGITKSMFILQYIFLGLICVTIDYLLTLPIIDNRDFSRAMVDNMGHALIGGVSWITVVGIHRKGILQAIGCAVMSSLIDVDHFVMARSLHLKNAVSLPHRPPLHATTILPFVVPILQVWCAQNIPCLHHLPYMFIVAVLSHHLRDAYRRGLWFWPMGSTPPLPYWVYLSCVVILPVIVRDAIEAIEKLPVSELGTDGLQGKAIQEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GWN3</accession>
    <name>A0A6P8GWN3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116286329</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031548664.1">
        <property type="nucleotide sequence ID" value="XM_031692804.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286329"/>
    <dbReference type="KEGG" id="aten:116286329"/>
    <dbReference type="InParanoid" id="A0A6P8GWN3"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000044">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18346">
        <property type="entry name" value="SH3_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="19">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="18">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="19">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1056"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="778"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="932"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031548664.1"/>
        </source>
    </evidence>
    <sequence length="1101" mass="119938" checksum="BBD9B0405222CB68" modified="2020-12-02" version="1">MILGCRVVRGPDWKWGDQDGGEGCVGTIVDLQKFADGQTLPSKTVLVCWDNGKQADYRTGLNDCYDLRVFDSSSAGVVFKDFTCDGCMTSGITGIRWHCTVCHNFDLCNVCYMNDVHDKNHAFIRFHISNDRTNGTNVGKXSDAVEKKIRATGIFPGALVKQGRDWTLDNDLGSKVGGVVGLTAWENTPRSAVLVNWGNSFEIKHRVGYEGKMDLCLVKAANGPCYYKDHLPVVSTISMPRSGGNELREGDMVKTELDVETLKQLAEGHGGWVDAMQKVIGKVGKVGRIDEDGDVHVQYGLFNWVFHPEALCKVTINLRTGDKVRVAGNKETVMNLQEGHGGWNNAMENVLGKAGKVIRVVDNGDMVVSIEDRVWVFNPDALILESKEEERTPAGHEDPSASATTALELLLHAMLEGVSNASSSETDFEPLLVATTVGNLEKVKQIIGSNKALVNQKFARNKTPLQVACHQGKSEIVSYLLENGADKELRDEQGYTALHHAAYGDETGVCVVVMLSANAKVNPTDLDRTKVTPLHLAVQRGNEAGVVALVQSKYCDVNCQDVLGDTPLHEAILRSQNNIFSHLLKAKNLDPTICNVNGFNILHLACLKNCQHAAKLLIEKFPGLVDITKEDGFSALHVVSINNHHEIARHLILSGHCSINMRNDEGMTALALSVSRSHKEMIELLIEHGVDVDVEDKDGDTPLHVAVMKHCIVHLGVDFQSLGLDGPAGNEAEKAIALFLVARGGAKSDYSNHQGKTPLDLCIDEELKEMLRRQDLVRRNKYQGGTPAALATQARPVPGSFRAPSPRTAVPLPIASPVAGNPNLIPTSPGSPREPCEAPPKSFPEPKPIPAKSAIGSSDDAKMLSTTKPLPIDPPTPVSKLPAVVPAIVSSRPINTKAMATAPGPATPSRSTAEATPAGDIPMALANLELKDDTSASNVVGTSSAESERRNTNNDISSEIRTSSNEKAKMVKSQKTNVQDELCRYCREEKADVIFKPCNHKVVCQGCSLRARFCLKCEKKINSKLAPGTEAPLLSLTHIKKDYENKIKELELLAICRICMDSPSNVVFRPCGHKCCHECARRLYRCHSCKEKIDERIVSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H023</accession>
    <name>A0A6P8H023_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116287253 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549774.1">
        <property type="nucleotide sequence ID" value="XM_031693914.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H023">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="GeneID" id="116287253"/>
    <dbReference type="InParanoid" id="A0A6P8H023"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="62"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="271"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="511"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="721"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="918"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="1506"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="1718"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="1932"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="2116"/>
            <end position="2173"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="2301"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="2500"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="2687"/>
            <end position="2745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1852"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2894"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2960"/>
            <end position="3118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2846"/>
            <end position="2873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1855"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2894"/>
            <end position="2904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2926"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2960"/>
            <end position="2972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2979"/>
            <end position="2994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3085"/>
            <end position="3098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549774.1"/>
        </source>
    </evidence>
    <sequence length="3212" mass="356403" checksum="AE5E19195E6CDE09" modified="2020-12-02" version="1">MDLRAAFPLGPKVDVFVTHVHNDSGNFFVQLNNEEAGKLDELMAEIDSFISSEESQGLTAGEIKAGTVYLAQYSEDARWYRARVIAVKAAICEVYFIDYGNTEQIPIKFLRIAKPSFLHLPPQVFECALENISKFRGPNMQDAVSTLKGLILEQELSCVTSSVSNDVLIVNLYKDINCRDSILSHLLSQVQRTPQATTTNGQEPLEIVDKKCFKTISLSKGNYIDVCVTDVQDPHXFSCQFVKGSEELLDLMDEIAKEYEDLKQGELPLQSSGVGYPCCAKFAEDFCWYRAVITNSSAVSSGFLEVKFVDYGNVQNTPVSDVKELQAKLLDLPAQTVECALLGIGPENKSKGWSTDAKTLFSKLTKDKHIVGEIYEKDPDGKYWVKLVDTTGEMDMQVDQILIAAKYAEKVSSNFQDVGRPQSGQGRSQSSPQSSTQIRSKPQDTLGRATSPYAKEVLTPGKEEKVLVSSVTSPSLFYCMFYRTSTKLEKLMSDIRRHYSRLGPEDEWLANPLVGDPCCAKFSEDQSWYRAVVTDVLTSGKVEVLFVDYGNSETVPSKSVKKLSPQFSELPCQGIKCTLNRICPKGSKDWRSTDIKAFEDLALECTGKLTVIALEDDELHRVELVVHERGKDINLAESMLLKGNATLIDGAYTQSENLVRVASRKFTNVTVNIGGYEDVFVSHVEDPGHFWCQLSKHQDDLNNVMTXIHDYCTSSKDVIRNPSLGLACCAKYSEDEAWYRASITGIKRTNKVEVQFIDYGNYDEVPLSDLRTIKPEFMELPAQAFKCRLAQLDVTTLITFPPEAIDKFCELTVDKELVLMIESFDKTHEQYLTLLLNGTENIFDTIAPLMPDVSSKEIVVPKQDIKPGRKENVCVTTVNGLSEFYCQFMCSAAHLDEMMIKMDAHYKALAPDQEQLTQLKXGCYCVGQYTEDDSWYRAKILXSNDNMYNVVYIDFGNGESLPASRIKKLSQSFSQLPQQGIFCSLAGNNSEFSDSQFGELTLDKMFDLKVVAIENDDKAKVELYCADTKRPLTEQLTKCQPETLLKIQPIPLNVGTTEVAFVVLASSISKFYCQLTKTAESLVNVMDKMYSYYDNLKSTQDAVSNPQVGVYCAAKFSEDDGWYRAMXSTVHGNSVEVFYVDYGNSEVLPLERVKKLKPEFVELPAQAIQCSLTNPKDFSTAASSRFIELVSDPETLFDLKILSMVAEGVFDVELIKKESGESLHQILANEGLLQEKEKPVQTETASVSLTIRETDEGQCGYAATPSQFWFNLNSNVDTLNSLLEDIGVYYECLSPTECVLPSPVVGSYCXTQYSLDQGWYRAKITAVQGSQVQVHFVDFGNSESKPASSLKVLKQEFQALPDQAILCSLHQAIPADGSSKWSPAAIQEFTDLVVEKDAVIRVVEKLPNDCHVVDVLDVSGSRDLVLGALVEKGLAANPNKTTDYKPCXMMLTEDGYIDVNPLICHSPQDFYCQVLSTDNIKTFGQLTYEIQDTYSKMGPNDNNLVKPEINMLCCALYAVDSSWNRGKITQIVDESTVEVFFVDYGNHEVVDLRNVKRLLPGFTDVPVQCVQCCLSDIKPSNGAQWSDKAKDRFVELVDHKQLVAKPSKTGKGKMEVTLFDTSDDTQDINIGETLVNEGLAVWVSSSSAEQRPTTALKTLESLENLKISSGDVXYITAVDSPDVIYCQVAGTEDKLDNLMASLTAFYESPQAMALSVQSVTAGQXCAALFSQDNAWYRAVVAGVSPGNATVRFIDYGNTETLALNDIRILSDEFTKEPILTVKCKLSGIQPSXGAPNWPKEATKFLENXGGDDGFKVKVIASGDILEVKLFDQQGDLCDRLIREGLAVARQQAAAKPVQKPKQSSPKQGNKPQTYKSPDIQVGGKIEVYVTDVTSPGQFCCQLAEFGDDLNQMMDSIYNHYSKLEDTAGCLVSPVVGQPCVAVFEGDXNWYRAVVQGMTLKDLNVKFVDYGNSQTIKPHEVKLIEPRFMKLPKLSIECTIDFQKSGWSKEETEKFTAVVGEDKMVAEILKEENGRYLVKIYKETKCITDSVLEKPAPPKIPEQVLQPNQVEDVYVVYLSSSTQLSLQLSKHSNALDELMAIIDNSCRASSIPLKQENIDVGMPCCALFEDGWYRAVIMSSPSSGQVDVHYIDYGNSATXAISDLRALPESCLGLPKQGVSCTLNDPKISAASKEMVENAVMDRQIKAKFLKKDGDYWTVELKIDGVDVADSLVEDSQPTATKTSTFTEQNISENSNAKVYVSHTVSPHEFYLQMDSSTEEMANLAIRLNALYPGSESNPLERLELGSVCCAQFSEDNSWYRSIVTAIPDDKHIGVQFVDYGNSDMVERSKVLALKEEFMDIPVFAIKCSLEVIQNTHKCTDKDIERFEALVFDQELDGVFLHKNEGKWQVRLNKDGNSLVNLLQENQERAPEEESVQQHSVTSIKDKEIIAGQEIECSLSHVEETGYFYLHVNGDPLIDEVTNMISEIYPSLDPSHENLGECKVGSFCCVKFSEDEQWYRAVVSEILSDSEAKVTFIDFGNSEVTSISSMKSLRPQLCEISKLAIPCRLDSTKDNWSEADTIMLEEKMLEKTLKVKFVSSGDRGWNVILDVDGTCLNNLPEFTSATELAPCSFTAASFTVNKKEPVIFLTAESLECIWVQPKNNENDLVGLMNKIAENKPTKAIDVSEISVGKPCLAKFTEDDEWYRAEVIDIIGAQILVKYVDYGNSEKVESSRISPISLSFTQLPTQAVRFCLLDVPESSASHVLDKLNEEYTETTVEAEVITQNDAGFYNVRLFDQEGKDLVNKLIRTNINNNAETKEPVAAVDVDLIVSQEEAPTEAVDENGIKAKEEDKKELEAEKEEFLEAQENVNGVVGSHDSADSLAETALLIASETTGATSSSNNLDDAGLQDLRASKSGVDEPNESELSRIEENKGAEKTKVVEDITVASDVVIPCRNQVLSSDPKTYRTSEIMQDFQPKVTSAPHSGDTQSKSPYESPKDKAIECQEDLPFETXKDAAPECQEDLTSETTKDAVIECQEDLPSETPKDAAPECQEDLTSETPIDAAPECQEDXPSEAPKASVPECQKDLPSERPKDAATECQEDLTSETPKDSAPECQEDLPSEILNDATKECLGDLPSEFLKDDSEHLNLQVVVTNGIHKFSDVRFDKDEECLSDEALEKLDTVLEQKPSAVKQVSGAVQALIXDKVQDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1T1</accession>
    <name>A0A6P8H1T1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carnitine/acylcarnitine carrier protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550349.1">
        <property type="nucleotide sequence ID" value="XM_031694489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1T1"/>
    <dbReference type="FunCoup" id="A0A6P8H1T1">
        <property type="interactions" value="1410"/>
    </dbReference>
    <dbReference type="GeneID" id="116287794"/>
    <dbReference type="KEGG" id="aten:116287794"/>
    <dbReference type="InParanoid" id="A0A6P8H1T1"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="122"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550349.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34073" checksum="6DFB1056851D252F" modified="2020-12-02" version="1">MSDDAGIVELEMTETKKKNASTSGLKNFFAGGIGGVCCVATGHPLDTIKVRLQTMPKPLPGEKPMFIGTLDCALKTIRNEGFLGLYKGMGAPIVGVTPIFAICFWGFNMGKKLQMKDPTADPTYFEILNAGMFAGVCTTVIMAPGERVKCLLQIQQASGAEKKYGGPIDCIKKIHGESGIRGVYKGACATLLRDIPATGAYFLSYEYLLKQFTPEGGTRGDIGAHKILVAGGFAGMANWVAAIAQDVLKSRLQTAPEGTYPKGVRDVFRQLMKEEGPTALFRGLTPVMLRAFPANAACFLGYELSMRLFNYLAPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2H3</accession>
    <name>A0A6P8H2H3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116288022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550599.1">
        <property type="nucleotide sequence ID" value="XM_031694739.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H2H3">
        <property type="interactions" value="2171"/>
    </dbReference>
    <dbReference type="GeneID" id="116288022"/>
    <dbReference type="KEGG" id="aten:116288022"/>
    <dbReference type="InParanoid" id="A0A6P8H2H3"/>
    <dbReference type="OrthoDB" id="5589010at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000006">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031550599.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="70379" checksum="B0C48555C01BD718" modified="2020-12-02" version="1">MDLGSEISVQIKAAIKAKLQELGSYVDDELPEYIMVMMGNKRSKKQMSDDLTLFLGDNTVKFIDWLLNLVDKLKDVTSLIDSLPSDNXTVTSNDTLNNGKVESKPKEYTKPTETRDKKKSSKTTSKEYSQSSSGKSVQSRIEKXQASNSDKHAHRKRRISESDEEEAPLKTRMPSVVKVQEKRPSLPPSKQATSSLLKRAVAEAHMSVTKMNPPQSHIYDPTSPPSPIKVHSIEEKQQQKEILLQQHRELQKKLKEKELEETVEDGPKIDXHENDVPNEKVKEVDTKSSTHNHNVPSLNVEVENEPLIELQVSEAEALEYSSENIKGDXRIVAFADSQTVNDTEEEKHKRRKKRAVKSRDRPKSPKFIVTLDGVDSDLEEKYEKQASRRSRHKKHKSEFDDYIEVDTSNMATTQLVVPAPEKPEYVPPAVEKVMFRVDPNSDDEEMQQYPIPSTKPQERCRFWPDCSNGANCPYYHPKAPCRTFPNCKFADKCMFIHPSCKFDGRCTNVSCPYTHKLKTKVRTPVAAPAQVIEPKIDDSLPTLSQLTPCKFFPGCTRTNCPFLHPKPTAAKVCRYGAACSRIDCKFSHPPSKAALKWVSPSLHPSERAFAVPAENVTKLPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2V1</accession>
    <name>A0A6P8H2V1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC116287401</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549933.1">
        <property type="nucleotide sequence ID" value="XM_031694073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2V1"/>
    <dbReference type="GeneID" id="116287401"/>
    <dbReference type="KEGG" id="aten:116287401"/>
    <dbReference type="InParanoid" id="A0A6P8H2V1"/>
    <dbReference type="OrthoDB" id="10066605at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578:SF6">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="8">
        <location>
            <begin position="12"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549933.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38171" checksum="31329E367206525F" modified="2020-12-02" version="1">MATAEPEKEATPEPNPEPLPEWETAFKEWNSWWEIHNFGFGCAFVILALFSLFCLVRLRSLQKLTLGRYFAAVSGLLLVFTTSRALYLLLDPYEGHKYLVLPVVVVRVIFALGYPCLTSVFSLINFAFVEVNSLKGILKKLQNIKFLSVVIVGHFLLVLIIYLTVTFSPPLANLFIICQSILILWWLALVTCFLYCAGLVFWDQKLKIKYFNSDSKTYELSDVVKTGKPSRSDPESQNVEKSKGARKIVRISCAVAIAGLISVVLEFYSLFGVYKLYSLDEKFVKPWPWWSYQTASRTIEICLCCIVAYIVYPTLKGRQTDATNNTNTKTTNGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2Y0</accession>
    <name>A0A6P8H2Y0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Minor histocompatibility antigen H13-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549796.1">
        <property type="nucleotide sequence ID" value="XM_031693936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H2Y0"/>
    <dbReference type="FunCoup" id="A0A6P8H2Y0">
        <property type="interactions" value="1921"/>
    </dbReference>
    <dbReference type="GeneID" id="116287272"/>
    <dbReference type="KEGG" id="aten:116287272"/>
    <dbReference type="InParanoid" id="A0A6P8H2Y0"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549796.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42070" checksum="80215BB0FB686AB5" modified="2020-12-02" version="1">MADAVVNETLANITAAANETAKNATGRAAATPEGLFTAYCGLIIMALLPIFFGSFRSVKAVIQQKESGEKPESMTPKDAAMFPIIASCTLLGLYIFFKIFSKEYVNLLLTLYFFVLGVLALTHLIRPTIELLLPSFFPNQVYTFDLTEGKGEEKKEVSHLDFDRIDLLCLGASAGFGVWYLLKKHWLANNIFGLAFSLNGVELLHLNSVTIGCILLGGLFIYDIFWVFGTDVMVTVAKSFEAPIKLVFPMDVLEKGLSASNFAMLGLGDIVIPGIFIALLLRFDHSRKGSKNVIYFYATFIAYFVGLVTTVLVMHKFKAAQPALLYLVPACVGTPVALALVRGEIKELFKYEDHPTEEEKTETPKETEVQEGAQNGESKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H3I0</accession>
    <name>A0A6P8H3I0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine kinase receptor Cad96Ca-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550158.1">
        <property type="nucleotide sequence ID" value="XM_031694298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H3I0"/>
    <dbReference type="GeneID" id="116287613"/>
    <dbReference type="KEGG" id="aten:116287613"/>
    <dbReference type="InParanoid" id="A0A6P8H3I0"/>
    <dbReference type="OrthoDB" id="5984176at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF583">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550158.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="46083" checksum="9100538D0199916D" modified="2020-12-02" version="1">MAEQAGIGLGCGVLFAVIVASSVMCFKKRRLPKTSDKGRYSIQGYPKDTTSNRRQKVLAKLKGTTVKSKKSNATEQIVAAKTLHDTADLNEKQEFLKEIDLMKKLGCYQNIVNFLGCCTTSEPNFLVVEFLPKGDLLKYLRTNRHKISGFEGKETAPAYLHTKSLLSQQEPQYTNSLASLQEADILSPATEQEKKLAIDDVLTPKDVLSFSFQIAAGMEYLSSKGFVHRDLAARNILVADNKQVKVSDFGLTRDLYEESAYNARVQRKLPIKWMSPEALYDQVFTTESDVWSYGVVLWEISTLGGAPYPSMSTRELYREVRRGYRMEKPDMCSDEMYKTMMQCWQENPKERPKFTELRQRFEELLQEDSPYVDFSNLDHNKDYYLVPSFNSAGDDEDGSACSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4I9</accession>
    <name>A0A6P8H4I9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287898</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550463.1">
        <property type="nucleotide sequence ID" value="XM_031694603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4I9"/>
    <dbReference type="GeneID" id="116287898"/>
    <dbReference type="KEGG" id="aten:116287898"/>
    <dbReference type="InParanoid" id="A0A6P8H4I9"/>
    <dbReference type="OrthoDB" id="5946437at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550463.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17437" checksum="15E0A578EE059704" modified="2020-12-02" version="1">MIKFTSFIPKNIRLSKPFCLARFWSQKKEDSGADQCGSYIKEGYLWKMKDGLPSRMWRWKKRYLVLSEDSICFLKEKGKAGKTPKIVRILDVVSLMIEDFGIRRKTFGIRLKAGNDRDSFLLRCRSEDERNDWVTAVLTAKSASLLTDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H506</accession>
    <name>A0A6P8H506_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein ceh-37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550613.1">
        <property type="nucleotide sequence ID" value="XM_031694753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H506"/>
    <dbReference type="GeneID" id="116288043"/>
    <dbReference type="KEGG" id="aten:116288043"/>
    <dbReference type="InParanoid" id="A0A6P8H506"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550613.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41500" checksum="F9477618E1C93189" modified="2020-12-02" version="1">MEEQIPQKSASMSSEEQSPKFPTCETKTDKNQSIQQQFSAFQQPHQIDPSSYSTLHGSPVSQMPFYPPRYYYQYYLPNTASLPSSVLSSCGIYPNVPPSDGVNDCRPKDKRRRCRTVFTQEQLSILEAGFNEQHYPDGKLRHTIATKSGLAEDRVQVWFQNRRAKEKRLLEEKKQSSMPERKEESDHETINAIQTIVSSDAIVRDENVCAVEQIKDTMYDNTESYGGSPQETFLIDSHQSNKQLLMTPCMDVASSQSANSSTTANPVSTTEQTVLENSYNEGDLTEAYSLGSSSQNLPRYIFSSYSSTSHDGALETPVRCHLVTDTNEQGELTELVVMDTGIQSSADGVSHSFENRYDAYTENHVIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H547</accession>
    <name>A0A6P8H547_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil and C2 domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116288790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551489.1">
        <property type="nucleotide sequence ID" value="XM_031695629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H547"/>
    <dbReference type="FunCoup" id="A0A6P8H547">
        <property type="interactions" value="3600"/>
    </dbReference>
    <dbReference type="GeneID" id="116288790"/>
    <dbReference type="KEGG" id="aten:116288790"/>
    <dbReference type="InParanoid" id="A0A6P8H547"/>
    <dbReference type="OrthoDB" id="19996at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006608">
        <property type="entry name" value="CC2D1A/B_DM14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21528">
        <property type="entry name" value="CC2D1A-B_DM14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00685">
        <property type="entry name" value="DM14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="629"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="843"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031551489.1"/>
        </source>
    </evidence>
    <sequence length="951" mass="105707" checksum="C2664CC7E738840F" modified="2020-12-02" version="1">MFKKKKEGNKSNDDHKKELANMLGGLGMDAEDMTFGMDIDGDDSDDDNASLEAELAALQGEVQHKRKKKQMGDDDDDDDDDLDNPELLAELQSIAPGEDVLSKNDPTPVMQPSKVQPPQESFLSSSVLDQLQAREKMYQTAIANAEKCGETSKAKRYGRGLKQVEQMIKQCKAGKAVNLDELAPEVATGSSASSQPPAPSIPQPTETPKVEVTPRNDSIPQNITATKDESKEVKNTSSAEKEQTIAILKTRQNQYKVAALTCKRSGNIAQAKQFLVVSKQIGAMMESVSNDQDVDISTLPPEPTLASPAKPKPETESRQQSGSPTSEPQPGPSTQPDQPSQSNNMGIPPPPKDVNEALQQRLEKYQQAANKAKEEGNSSKARRMGRIVKQYEDAIKAYKAGRHVDFEELPTPPGFEDIPLPGNAAPKPSAQAEGPATTSEPQALKVRIPQPAAQMPPQQQHGSLNRQGRNEQQLNFLLERQKEFKTAALKAKKQGDIEEAKKWLRMSKGLDPMIENASNGMRVDLLSVPLSPLTSQGPAPTASANFVMIETKDCMPNPRTPEEITELYARLEDCLIKQTEMCIKNGKHYQQLGDLSSAKMYDKMAKSLHQDLDAVKSAKKHKDPPPKFHYEDKTFTVVNSFSELSNSEVEIEVVRCLNVPLPSGYSAKDMYTYVAFEFPYPNVSICYIRNSQTHIYFVLEYNESFKVNIDRKNRTLARIFKRQNLKFEVKYERGFLKGDKAIGQAQIKLAPFDSKCEIHECIDLMDTDRGRKGVGGKLEVRVRIREPLTGQDVQMEKWKWLVIDMHLGGKKTPDLDVGSIMAKTSPTPGRAVTQGSINDLVSVEVLKMEKQLAERQASAQKAKGQTPSPALLQRYKQCSQKMEQLQTMLSKADKKILENYVHQLVSQIKVEQSNAQRALQAGNKTEAHLCNTRKKLMQNEIISFKPKLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5H1</accession>
    <name>A0A6P8H5H1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116288896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551619.1">
        <property type="nucleotide sequence ID" value="XM_031695759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5H1"/>
    <dbReference type="GeneID" id="116288896"/>
    <dbReference type="KEGG" id="aten:116288896"/>
    <dbReference type="InParanoid" id="A0A6P8H5H1"/>
    <dbReference type="OrthoDB" id="5979347at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031551619.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20165" checksum="63C4622EF02BDF77" modified="2020-12-02" version="1">MGFKAEQFVKSVDENLFCAICHEVFDNPVGSKDGHLFCKDCVHIWLKKNTTCPLLGIGYLSKKYLVPQFTVKGIIDNLEVYCHPYGTQDKPSDDNQSNSQGRKEGKTEGRKEERKKGRKEGRKEGRFLKHTYFIPVQKSEILNLRPINMLQTAIYLIYAEQRNLLLDWKMKHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5V5</accession>
    <name>A0A6P8H5V5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288220 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550846.1">
        <property type="nucleotide sequence ID" value="XM_031694986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5V5"/>
    <dbReference type="GeneID" id="116288220"/>
    <dbReference type="KEGG" id="aten:116288220"/>
    <dbReference type="InParanoid" id="A0A6P8H5V5"/>
    <dbReference type="OrthoDB" id="5958892at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028133049" evidence="2">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550846.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15470" checksum="D8EB018DB00326F3" modified="2020-12-02" version="1">MKVLILFPFIVFFGGGFAQTQQSCVNKVAIPQCLPALANYLQSQASLLQNLSQELQTAKQETEKVKASLGQWPAGSYCILASGGCPKGFTKKSGHMRALNMYSHTPTYIQPVHFGSSRITCHGKCGQYGNWVGDLYISACCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8G4</accession>
    <name>A0A6P8H8G4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116289928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552734.1">
        <property type="nucleotide sequence ID" value="XM_031696874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8G4"/>
    <dbReference type="GeneID" id="116289928"/>
    <dbReference type="KEGG" id="aten:116289928"/>
    <dbReference type="InParanoid" id="A0A6P8H8G4"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552734.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="50383" checksum="0A9C672871CC34D3" modified="2020-12-02" version="1">MAEEASGKEGDSSSEETTPRYLHFPDEEAEEMDQGERIRTIISFFGVGLIMHGLFSIIISGSQDILGGTYIPTTAVIIAHVGPMVLIVYTFPWFMQKMSYFIRILAVFAFMAGGFVVISFVENPYLKIIGVSLNAVAHALGEITFLALGTFYGDISVTSFAAGSGAGILVGPVYYLGLTSWACVSPQETMIFASAGSLLILVCYYILNKDRIKSHAIAATYNSTKYSVVPINSKGDPVQLAWSEKLSAAMKIAPFMVSLCVAYIMQYLTIQSVFTTMSFQNSPFHPRDHYVYYVAVNGLGELVSRSYLGILFCVKPQVAVKIAVNKTWILSVLLTGLFALSVCASWFRFIDNAFVVLFMSFLVGFLSGSVYANTLVSVRDSIEPRYQEFCLGLVTAGIDSGALIGSFVGLWLEPVLRTHCQRMVPKGASYCFTRHEKRAWTEAICNGKPVKIKIEIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBT9</accession>
    <name>A0A6P8HBT9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC116287425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116287425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549965.1">
        <property type="nucleotide sequence ID" value="XM_031694105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBT9"/>
    <dbReference type="GeneID" id="116287425"/>
    <dbReference type="KEGG" id="aten:116287425"/>
    <dbReference type="InParanoid" id="A0A6P8HBT9"/>
    <dbReference type="OrthoDB" id="5974723at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF42">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="10">
        <location>
            <begin position="362"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="11">
        <location>
            <begin position="456"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031549965.1"/>
        </source>
    </evidence>
    <sequence length="788" mass="88659" checksum="D303A0D6604F3869" modified="2020-12-02" version="1">MEQARSTTQQDQVWRNGAFKAVVKSILNPRETEHNYKLYINSLKRYKTFEEQLKGESGRYVELLMSGSMAESLFATHWVYEDGRREAKNDIDIMLVDFSMKVVERKAVNSSVGFNDFAAVVHDNNHFSTAELSHPMDQKCYDQKDVPLLDTEMSATGSLQNGSGSERSSEEFAWNINGDSRESEDPTGDSTPGDSTDPGSLQNESGSERSAGDSEDSTGDSGDSEGCAGDSIAGDSNDYDDSTDGDSTNDDSADGDSTDPESLQNGSGNENNSGHSIDSAEKREYTQKDLFLETTDRPGYVQLRYEPQKEGKSAFLSTDNFKEFWREIVNKTALYSLVSGPQLPSGGVLATGPALNRRDRPNSRNNYAHDYVPCLQCPEWPSIANNWSERSRTMGWPSKDLISDILSKGCHVVPVSHHDSTSYNTEWRLSFSLAEKMLVNSLSKEQRQSYIVAKLIMKEVIQEIKNNAFLEKTPSSYHLKTILLWKCEEKKLEEWNNILNSAVELLESFVDHLLRGNIPNYFIPENNMVSHISHQGLVSVANGIAASLEDIPATLHRVFQTAYETVLDFDNDYFPVLRLVNCELEMFCQTGTAGNKLYLCYILNSLVDSLSAAIIGTSDELQHLDDHKHILKIYCTHQIAAGNPLTLPSPPVLGAAEQSTTVMLLFQYLYTLLQDDHILTQLQNDIFAILSRIFTRILPVISLNLSEEMFCDCCEESLRVYQRVCTKLKIELSSYRSCHEELIALRGLDFIFFKCNELAEMEAFEFAAKRFQKFKEDGQIEKAKSLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDF1</accession>
    <name>A0A6P8HDF1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116288014 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116288014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550590.1">
        <property type="nucleotide sequence ID" value="XM_031694730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288014"/>
    <dbReference type="KEGG" id="aten:116288014"/>
    <dbReference type="InParanoid" id="A0A6P8HDF1"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF293">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="95"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550590.1"/>
        </source>
    </evidence>
    <sequence length="740" mass="84141" checksum="1398B61C1A6FC374" modified="2020-12-02" version="1">MAESKEDPLHLRSLTADGIVKNKLKSLELIESQISEAFIELTSSIDHVKLDSKLSVVRSLLLGAITNIKTFKEVCRDEANSSLNAGKVSQDDLMNSKWTRLGEGGFSNVFKATLKGNVVAIKVLKDFKESKALFTEGNLLRDFRHDNIVAFRGMDVLEQKISELNLNAGSPFIVMEHIPNNLYKYVESQRTPETRGLPLGQVWNFVRQMANGLYYLHSLAPPVSHRDLKPDNILLNIRSMQVKLADFGLSRQIYTSSEGMISMFQARWTAPEIWKCFEDDPEYHNIDGEAQESTCTLEEEIEDDVFFYLRADIYSYGQVAAYLLTGDRPWPGRNSLSVADIREKAVVKEDQVVLPDELTGPLKDIIKMCRDEDPLKRXTIQQLVNEFFASDENPYQSEAESAEFFSCGFLKDTKIFVADSLVDESSEGYNKTNETPQGYPAECLLCEVEVGNDDYNTSPQEWIYEQKYREYYAHFKLKAIEKKIEDNPAIALKHLVTPREDEEERQEILLRYGQSTYCHHRAMREIWMKVLDETKRREIVPCKSVIHPIFSTSFGLHVAVITADSPPKFIFARRANREGMATPGKFTCGAVESASVKDYEFKDGKAFVNLIQTAARGLEEELRVELHGDDVKALCLSTVYLKFDTHEWGLCGFVDLSDKRIDPKRRLTFEQLGSRFSAGPKDKFEHEEVKAVDFTLPTMVDFVSENYLDFASSAKLVVVKVLQSFFGVAAVEQAFKSLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEI2</accession>
    <name>A0A6P8HEI2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA 3'-5' helicase Q1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031554834.1">
        <property type="nucleotide sequence ID" value="XM_031698974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291766"/>
    <dbReference type="KEGG" id="aten:116291766"/>
    <dbReference type="InParanoid" id="A0A6P8HEI2"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="197"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554834.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="38623" checksum="249C9D59B533D764" modified="2020-12-02" version="1">MAARRQEFDLFRDALDYGLKIIGKGDLKLKEKQYQVLEAILIGKGDLNLKEKQYQVLEAICLKEKDVLAILPTGYGKSLIYQVLPPVMDFLSSYNINLLINTTKRTVIVISPLTALIQDQVSKLKESGLNVCLLKGDRVTKGVDEKESQPLDCMLNIFTNVPVMGLTATTTKKARSEIVASLGLIDPIIIESNPDRNLDRHKLDFPLTIVFGNLETISNCFAYMSEKMGKRQYHPLGSLEMASNRLFTQYHAQYPVHEREKIVDGLLSGSSKLRIIFATIAFGIGLDLRNIRNVIXTGVPYTLEEYFQEAGRAGRDGLPSKAIIYYNSYDISRAKTKIVGRDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF34</accession>
    <name>A0A6P8HF34_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine/arginine-rich splicing factor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554351.1">
        <property type="nucleotide sequence ID" value="XM_031698491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HF34"/>
    <dbReference type="GeneID" id="116291321"/>
    <dbReference type="KEGG" id="aten:116291321"/>
    <dbReference type="InParanoid" id="A0A6P8HF34"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12337">
        <property type="entry name" value="RRM1_SRSF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000028">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000420">
        <property type="entry name" value="serine-arginine protein 55 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554351.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37838" checksum="09BA391D09ECE044" modified="2020-12-02" version="1">MSRGGTRVYFGRLPRDVRERDLEKFVRNYGRVREISIKLGYGFVEFDEPRDADDCVYDLNGKDFLGERIVVEHARNPVRNVDYGYRSRESSRSSRPPPRRGRTPPVRTEHRLAVINLSSRCNWQDLKEYMGKAGEVTFADAHKRRAGEGVVEFATKEDMKTAMKKLDDTELFGRHIKLKVEKVRTRRSASRSRSRSRSRSRRKSRSRSRSRSPKRRRRSSSKSPENSKSKRSKSRSRSASREKSKEKSKSRSKSPERSRSAFPKKEHENGEEDEEVKDVDEVDEDQEAEPEEQEQVEENGEEENADEENMEDDDVEKKEGDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF40</accession>
    <name>A0A6P8HF40_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288521</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551190.1">
        <property type="nucleotide sequence ID" value="XM_031695330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288521"/>
    <dbReference type="KEGG" id="aten:116288521"/>
    <dbReference type="InParanoid" id="A0A6P8HF40"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551190.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27930" checksum="0B4E998F6FC2E6ED" modified="2020-12-02" version="1">MAFPSCRSVFITGCNRGLGLEFVKQFLNLPSPPEFLFATCRSLAAESANELKQLASKNKNLYLIELDVDDYEAIKKVASEVGEKLQXEGLNLLLNNAAIMSREVIGEITPEAMMRVYKTNTVSPIIVIQGLLPFLKTAAQDPEDRSLPKAAIINVGAGYASSTFRRTRVPYPYTASKSALSCVTRLMDVDLKSFGIGVFACDPGWVATDMGSEEPVGKPPLTPEQSISGLMKTFGSLDEKLTEKGAIRYDGQIVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFR9</accession>
    <name>A0A6P8HFR9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554656.1">
        <property type="nucleotide sequence ID" value="XM_031698796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFR9"/>
    <dbReference type="GeneID" id="116291614"/>
    <dbReference type="KEGG" id="aten:116291614"/>
    <dbReference type="InParanoid" id="A0A6P8HFR9"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="173"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554656.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39188" checksum="CFFA03C0240120C8" modified="2020-12-02" version="1">MGKAIVFEILPHRREKTYHPGEVVSGECVIELKESLKFRSVNIEFIGEARTTWDEMQNYTTTHKDEEIYFHKKSSLISSGNEKKGSVSVLSPGRHVMEFTFKIPPFSLPSSFDSKHGHVRHYLRARIIRPWRFDEVTKEDIHVIDLIDVNCPRMLMPVFGEAQRSLNCLRNGTAAPLQALVQSDRSGYCPGEKASLIVEIKNLPLTEKYQTTIYLIQNVTYKSRCGKHRNDYKRLKLLQRSSSSNKCDEVEIPDVVPSMRNCGILSISYYLKVVIALVQGQDSGMDLEVDLPITIGTVPLRKSYGLISKMIPCSQLNESKFNNKTFVTIKHMSQVNLFSLSAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG01</accession>
    <name>A0A6P8HG01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551507.1">
        <property type="nucleotide sequence ID" value="XM_031695647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HG01"/>
    <dbReference type="FunCoup" id="A0A6P8HG01">
        <property type="interactions" value="1654"/>
    </dbReference>
    <dbReference type="GeneID" id="116288806"/>
    <dbReference type="KEGG" id="aten:116288806"/>
    <dbReference type="InParanoid" id="A0A6P8HG01"/>
    <dbReference type="OrthoDB" id="5914890at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551507.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27353" checksum="C64874D8B09A866E" modified="2020-12-02" version="1">MAAVEKVRILVVGDSGVGKTSLVHLICHEESISSPAWTIGCTVEVKLYDYKEGMPGNKTFFLEFYDIGGSANHEMSRSIFYHSVNGLILVHDLTNKKSFTNLRRWLREVLNSSNSSSSSTKPSDSWFGSDFVEDFDPEQFAGNQIPVLVVGTKLDQAGSSRISNSTRGMNLVDEIGADVININCNDLTQLRPGHVNSKKLRNFFDKVIERRFHTRDTSQSLFAYQDGPKFYQERGSKRKQFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH47</accession>
    <name>A0A6P8HH47_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Myocyte-specific enhancer factor 2C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC116289149</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551884.1">
        <property type="nucleotide sequence ID" value="XM_031696024.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551885.1">
        <property type="nucleotide sequence ID" value="XM_031696025.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551886.1">
        <property type="nucleotide sequence ID" value="XM_031696026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289149"/>
    <dbReference type="KEGG" id="aten:116289149"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031551884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031551886.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="50848" checksum="220C8E1BE714A67D" modified="2020-12-02" version="1">MGRKKIQISRIGDERNRQVTFTKRKFGLMKKAYELSILCDCEIALIIFNSANKLFQYASTDMDKILLKYTEYNEPHESRTNADIVETISKKENKQISSPEDTDKQFVLTPRTEAKYNKINEEFDQMMKKNYVPQQNPDGYPQXMPVSVPVSQNSNGSDDTNGYSVSRSSSVDTIGSSSGIGNANTAGRISTGTPNQSNPGLSISGPQQQTMSDLVAAAEMNTNKQSITGQYQRSTNSVGSDHGSGFPAPAVHSGRNSVSPNPQVSQAPNRPHLKVVIPSSNRPNAQMGNRGNLSSNSQVQFSQGSYGLSTPVISLATPSNPAAPPSFTSMPSGFPSELHPDSADVLKQLGQFPQLLPQQQAFLQQQINLQNLQALSFLQGNPGLMGGANLLGNRLTVPSSSQSHNLVNVKSEPVTEHDPSSPGSRSSVSPTSPYCRQTXSREGREMDMSENNMPKRQRLDVTANGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHA8</accession>
    <name>A0A6P8HHA8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptide Y receptor type 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116289238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551987.1">
        <property type="nucleotide sequence ID" value="XM_031696127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHA8"/>
    <dbReference type="FunCoup" id="A0A6P8HHA8">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="GeneID" id="116289238"/>
    <dbReference type="KEGG" id="aten:116289238"/>
    <dbReference type="InParanoid" id="A0A6P8HHA8"/>
    <dbReference type="OrthoDB" id="10015690at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031551987.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40922" checksum="E92A52CDBD8F0AAD" modified="2020-12-02" version="1">MKQEMANDSSSPGDSNSFILVSNSNQSYSNPADLEWRGKLGIDITIFVVAVIGNLAVLVVIYTTRERRKTPFEILIANLSVADILSVLLYSTIQYFNIPLSKWYCKLVAPFFSSTQMVSVLTMTTIAIFRCRSIVYPFKTKPSMKLTYCTVAGLWLVANICLLPVYIVREQNQGRCEEIWPSELLNKVYTVSLFVVQYMIPLTIIAISYTKIILYLKRHKVSRCGLNSDRIKQLKMTRKRDLEVIKISFIIVLLYNISTLPGQIAWIVWIVFERYEMALVIFKFSYQLLLFHSCCNPFVYGTISREFRSRFVQVFWSIFCCICKMRKTKTVVLQTEQGHRNNACVDLEIIDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHT6</accession>
    <name>A0A6P8HHT6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histone H3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116289405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552177.1">
        <property type="nucleotide sequence ID" value="XM_031696317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHT6"/>
    <dbReference type="FunCoup" id="A0A6P8HHT6">
        <property type="interactions" value="692"/>
    </dbReference>
    <dbReference type="GeneID" id="116289405"/>
    <dbReference type="KEGG" id="aten:116289405"/>
    <dbReference type="InParanoid" id="A0A6P8HHT6"/>
    <dbReference type="OrthoDB" id="6017156at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031552177.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17238" checksum="258C443DEBA696A1" modified="2020-12-02" version="1">MKYSCISFCSENTARKMARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHY8</accession>
    <name>A0A6P8HHY8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116292779</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555994.1">
        <property type="nucleotide sequence ID" value="XM_031700134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHY8"/>
    <dbReference type="GeneID" id="116292779"/>
    <dbReference type="KEGG" id="aten:116292779"/>
    <dbReference type="InParanoid" id="A0A6P8HHY8"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46549">
        <property type="entry name" value="MACPF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46549:SF1">
        <property type="entry name" value="MACPF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027658458" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="4">
        <location>
            <begin position="260"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555994.1"/>
        </source>
    </evidence>
    <sequence length="1229" mass="137522" checksum="8F45C383C5A33B20" modified="2020-12-02" version="1">MVKTLLVVVTLVTFLTENLCNQQPGLNSKHQVRQNGAEHLYNYPALKNHNDRSVPRVSNNVPNNQIYWNNFLNKVSLSDGGNRKDKNQFANINPNETKRENDSLKLPKQQRKNLLAKVIKKTSINPEANPANDDVTASKRVAPVVTGALTKLAGNEKVQEAVVDKGIEVAGKLVDKYFENIDEAQKKSSEFLKKQIKLDIMPDKGWETEDMFVPPGYHINAEVEGSEPSTGADDTVQPYNYPAGIGGVLMNGCWGTDYKEGDPCYNAMEKTEQCRDMIDGAAFIGVGFDGRGQYSPESRKMSIIQRSCGGHSSYDNLQVPDTMNVHGIYDTSAHMTVFTSRSEYQKYLQNEAGVSGSVLGFYAGVKTAWGSSESGAKQTNLAIFDIDVDRYEIFQDEVKPQDLSRSFLREFINLPNSYFEPGAPAKFQDFILRWGTHYTKSARFGGQLELRKTQLASMTASKEEFAEESETEFKSLFWSAGAKSSTKSGSSSKSQRNYMSTSVVVQGGSQRIAAVISDMYSPTFKTEFTAWLESIPAYPKAFKFLMGSVTDLLNFRGNDLFPDETIVWGCEINKDKLINDEKSGKSYYMNQNKRVYCEFSSREEMEYSLKRKRVSLKRAIEVYMEEGTMSISDVSLPAGEAGCQSRNPEYQSETTKPSWDEMTKKHKRFHVIFDMLKDLRGAIHGGIDIPKSMSRIVQFSQGKWYTTNENGEFHIYDGFNNGGSGDKTNKKISIFGLVLQYDESEGSLALNQADYAVSQRYFPELSEILKGRQLARVEWPTANSFTKSNQRALGQLPCNLQWSNGLRFDPSDRNGKCLHFTASTKGALYVVFSAVPSNKDAWYYVEISPFGVAIYKSQRLKVSTVNTNAVALGDALLYQSYFVCVTESPTSTVIEYGKSQGTTDSGDVYLTMIDHDQPLHVRFYSFANGEESAQIVDSHVVSRKLTAADCKGDTYRDKEEPNCVQRCHEACAPLAGCKSHSQGNPKASECNECRYAKDQSDVCITECPAGQKPNKQKNCMESFDLKFKQDTGFEDSDITGFPTLNEMAICFWINSQGAEDNHYVVLNYVNKGEAHTLFQINAVVKRDVKISYYIGEKGKQPNSGRFLKFKKDDKWHLYCVNRESSTGIMSLFIDGKNVLRPTITLIEQPGRVPEAGGTMHLGGFRDKNFRGKISGVNIWNRLLTETEISKMAESCGDAAGNVKDWFDIKSELTVSKYTLTAPSACRANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJF9</accession>
    <name>A0A6P8HJF9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flocculation protein FLO11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552817.1">
        <property type="nucleotide sequence ID" value="XM_031696957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289992"/>
    <dbReference type="KEGG" id="aten:116289992"/>
    <dbReference type="InParanoid" id="A0A6P8HJF9"/>
    <dbReference type="OrthoDB" id="10436849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028026874" evidence="2">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552817.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="24896" checksum="7553312E3014A6E1" modified="2020-12-02" version="1">MSLIGRLFSLTNAFLFVVVKAVNTSVTPVYSAIGTIESSRTVSSSIIMNITNTNVLLPPTSTVRWYENATIGNATSSTMYSNHITTPTTTTTVDSSSSVKPTPTSTAEVDYGNSTITTITTTADSSSFIKPTPTSTAEVDYGNSTTITTTADSSSFIKPTSTSTAEVDYGNSTATTITTTADSSSFIKPTPTSTIQWSSSNSSIIPTTDSGPSTLPPTQPPYGXATTTGKARAMNYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKK0</accession>
    <name>A0A6P8HKK0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">G-protein coupled receptor 161-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC116293074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556326.1">
        <property type="nucleotide sequence ID" value="XM_031700466.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556327.1">
        <property type="nucleotide sequence ID" value="XM_031700467.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031556328.1">
        <property type="nucleotide sequence ID" value="XM_031700468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKK0"/>
    <dbReference type="GeneID" id="116293074"/>
    <dbReference type="KEGG" id="aten:116293074"/>
    <dbReference type="OrthoDB" id="5969750at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031556327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031556328.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40045" checksum="3150B1BD1F0EE912" modified="2020-12-02" version="1">MGNVTRIPLNETGNGTNIVRQTPQVIDRVPSFRPGQTLTAVAIQLGFALALIVAALTINIMMAIVLNKKFMGIPYMMLKNIVAVDIATALLNGPFFALGVILDSMGIIIKSYCNVQGFFHASLSAVFLNTVTLIAVSRCLAVLKPQLYHKIFVNKITMHILLLAVWSSSSLLCVPPLNTKGWGKYDRFEATCWMAWIPENDDYIAYNSLLTILTLGTAVVSCSFGLYFLYSIRKVGSVTPAQTATAPPPYPGTANMSVPEKTSQKKVRLNTDVFIIASTQFAVYIVLWVPLTVMNSIYLKDWRDIEFRVITFFLFVFMGRTIINPILCLVVSADIRREFAKTIFRCRCKRDNETSEQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL09</accession>
    <name>A0A6P8HL09_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COMM domain-containing protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555598.1">
        <property type="nucleotide sequence ID" value="XM_031699738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HL09"/>
    <dbReference type="FunCoup" id="A0A6P8HL09">
        <property type="interactions" value="1731"/>
    </dbReference>
    <dbReference type="GeneID" id="116292418"/>
    <dbReference type="KEGG" id="aten:116292418"/>
    <dbReference type="InParanoid" id="A0A6P8HL09"/>
    <dbReference type="OrthoDB" id="17646at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055184">
        <property type="entry name" value="COMMD8_HN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22838">
        <property type="entry name" value="COMMD8_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="121"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555598.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21269" checksum="0DB4AC33A7A3CCFC" modified="2020-12-02" version="1">MADEATSKTEGVALLEKCPKEQAEKFVHQILDGICDGKEPRYVDYGKIWTTEQWQSVRRGLHVTLKNFICKDFGKDEIFKELDQYSLSPDIKQVVFGCILARKDEIRAALVSNTAGITNAYLKDFDWKVKMVLASDKIAGIRKSVVSVDLDIQQDNTVRPVTVEMTKEELGNLITSLEAANKMVVQLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPF0</accession>
    <name>A0A6P8HPF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556938.1">
        <property type="nucleotide sequence ID" value="XM_031701078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPF0"/>
    <dbReference type="GeneID" id="116293622"/>
    <dbReference type="KEGG" id="aten:116293622"/>
    <dbReference type="InParanoid" id="A0A6P8HPF0"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556938.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29014" checksum="C0F059B14D4E4B0F" modified="2020-12-02" version="1">MRRMMNDGGGQENKRWSKIYCSRFLAVLLVISMIHVAASQNKRRFLEHGWNKIRSSIYAQATGKTNTHSSMVCKTTECIEAASQINSSINLAVDPCDDFYEYACGRWPINNPIPPGYSYYSFTKIAELKADKYKRRILETGKIRVNGASNEVQQMPSYLYKSCMNLTVIDNLGDAPLRERIRELGGWDMSGDWDENTWDFNETLLSIHKLESEGPFFKVGIISNNCCRSRASCGDKPRSPPLHISSPFSAKTKMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPS8</accession>
    <name>A0A6P8HPS8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294196</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557606.1">
        <property type="nucleotide sequence ID" value="XM_031701746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPS8"/>
    <dbReference type="GeneID" id="116294196"/>
    <dbReference type="KEGG" id="aten:116294196"/>
    <dbReference type="InParanoid" id="A0A6P8HPS8"/>
    <dbReference type="OrthoDB" id="5945672at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557606.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="46019" checksum="5F3EBAC6A2B0A9EF" modified="2020-12-02" version="1">MEEFFLIWESSCRNFIDELEFSCQEAKETRLKIHVFLRSDTPEKAMPPERDWIETHFTLTTCPYASDAAITFYLLERYATEKKEKEKWLEELDVGSSLILVADKDRKFEEVCAILKVKNPRLQVSEVNGKEKSILEVLENVCRRCKLVFLTESEMEDHFYQLHNFFCYNPECTEGRFYTESELQKHLENQTHCPLCKEEYVFCNDEKRSAHMKNIHKKDEMVSSRTTPTSEAIVCQFCTHKKFSSSQQKEIHMKNCHKKCNCSCGKYFNTREDYLDHFYSVYPLACFENRKCPQRFQSVLYQARHHREDHFSTQPFYCIPCQEMLVNEGGYKTKICFKDEKSLRIHGMSIGHNEDEMFLSDFRESLKVDQPLVQRRAPSRTCSAINYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ10</accession>
    <name>A0A6P8HQ10_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116291665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554722.1">
        <property type="nucleotide sequence ID" value="XM_031698862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291665"/>
    <dbReference type="KEGG" id="aten:116291665"/>
    <dbReference type="InParanoid" id="A0A6P8HQ10"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554722.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26148" checksum="E546EF3AF4A84266" modified="2020-12-02" version="1">MATGRCPPSSDEQFTRGRFSGKVAIVTGGASGIGEXTVRRFLNDGAAVAIFDINDKLGKELETSLKSSGHEVVFYSVDVSDRDQCIQAVDRVASDLGRVNCLCNNAAYFGAKGVDARKEDWDKTMAVNVQGYSNMVQACLPHMKKNGSGHRAVVNVASISAYVAQPFHWTYSSSKGAIVSLTKCMALDLAVDGIRVNSVSPAWTYTPEVRRADILANNTGAWRVCAVEMEFVVQQLTKDISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ67</accession>
    <name>A0A6P8HQ67_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116291757</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116291757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554825.1">
        <property type="nucleotide sequence ID" value="XM_031698965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ67"/>
    <dbReference type="GeneID" id="116291757"/>
    <dbReference type="KEGG" id="aten:116291757"/>
    <dbReference type="InParanoid" id="A0A6P8HQ67"/>
    <dbReference type="OrthoDB" id="8963064at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031554825.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="8336" checksum="6C1D411E6EBE115E" modified="2020-12-02" version="1">MVYTTIPCIHVIHFNTLYHPTIPCNTLQYPVMHYNTMYTTIPCKCNTLQYPVIHFNTMVYTTIPCNTLHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQG4</accession>
    <name>A0A6P8HQG4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Keratinocyte proline-rich protein-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Keratinocyte proline-rich protein-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116291846</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554919.1">
        <property type="nucleotide sequence ID" value="XM_031699059.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554920.1">
        <property type="nucleotide sequence ID" value="XM_031699060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291846"/>
    <dbReference type="KEGG" id="aten:116291846"/>
    <dbReference type="OrthoDB" id="10548181at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653086" evidence="2">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554920.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="33585" checksum="FA03CE6C3E63C1F4" modified="2020-12-02" version="1">MKFLLVAVLVLASVAHLKAEKEDEKLLALMEMDEDAALDMILSDNEEDALRPTWRPFPSMRPFPSWRPFPSMRPFPSWRPFPSMRPFPSMRPFPSWRPFPSMRPFPSWRPFPSMRPFPTWRHFPSRRPRPSRRPRPTPPXFVVECLREFKKCMNESGNDLRKKFKCGLNLGKCIRDNRPTRPPSDESDARRPRPSGRPRPSRRPRPTPPSFVVECLREFKKCISESGDDLGKKFKCGLNLGKCIRDNRPTRPRPSGRPRPSRRPRPSGRPHPSRRPRPSRRPRPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQS3</accession>
    <name>A0A6P8HQS3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">THO complex subunit 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557896.1">
        <property type="nucleotide sequence ID" value="XM_031702036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQS3"/>
    <dbReference type="FunCoup" id="A0A6P8HQS3">
        <property type="interactions" value="1716"/>
    </dbReference>
    <dbReference type="GeneID" id="116294440"/>
    <dbReference type="KEGG" id="aten:116294440"/>
    <dbReference type="InParanoid" id="A0A6P8HQS3"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000300">
        <property type="entry name" value="THO complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001007">
        <property type="entry name" value="THO complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25174">
        <property type="entry name" value="Beta-prop_THOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031557896.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35919" checksum="31FCCBEC9D90DE5C" modified="2020-12-02" version="1">MDYLNEMRKYFENNGKTKDFTAHNSKVHSVSWSCDGRRLASGSFDRTASVFVLDKDRLTLDNKYKGHNESVDQLCWHPTNPDLFVTASGDKTIRIWDARSTKCVHVVNTKGENINICWSPDGNTIAVGNKDDLITFVDAKSFKARHDEQFKFEVNEISWNNTNDLFFLTNGHGCINILSYPELKPLQTLNAHPANCICIKFDPTGKYFATGSADALVSLWDVDELVCVRTFSRLDWPVRTLSFSHDGQMLASGSEDLVIDIAMVETGERICEVQCHSPTFTVAWHPNKPLLAFACDDKDKHERDAGTVRLFGLPNNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQV8</accession>
    <name>A0A6P8HQV8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COMM domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558769.1">
        <property type="nucleotide sequence ID" value="XM_031702909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQV8"/>
    <dbReference type="FunCoup" id="A0A6P8HQV8">
        <property type="interactions" value="2920"/>
    </dbReference>
    <dbReference type="GeneID" id="116295155"/>
    <dbReference type="KEGG" id="aten:116295155"/>
    <dbReference type="InParanoid" id="A0A6P8HQV8"/>
    <dbReference type="OrthoDB" id="284322at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF4">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="130"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558769.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22198" checksum="28A633C0C628184C" modified="2020-12-02" version="1">MRFRFCGDLDCPDWVLAEISTLSRISSVKMRLLCAQVIKNLLGENIDYAKVEKLTSDAKYELGDVKATIAALSFILSSAARYTVDGDSLLNELQQLGLPKEHSGSLCKLYGESLSKLQEAFLDKTLKLDGISNLEWRVDYVLGSSELEKIREAEVQVKFNKTSANNQEGEPVAFTVTSEKFRVLLAELKQAYTLMEGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR73</accession>
    <name>A0A6P8HR73_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116292038 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555135.1">
        <property type="nucleotide sequence ID" value="XM_031699275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HR73"/>
    <dbReference type="GeneID" id="116292038"/>
    <dbReference type="KEGG" id="aten:116292038"/>
    <dbReference type="InParanoid" id="A0A6P8HR73"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF24">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="508"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031555135.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="62266" checksum="6C6C3F037FD64C36" modified="2020-12-02" version="1">MTREEGEDAVFMFNTSTSILEVAWGIRDGNSINLKPRLIRVDIISGVQLTPNAGYAGRVSFVGNLSKAQAWFKITNLNINDTNQYMAKIRVRGTSFYKYIPAQLTVIKQPVLISSPGPLTREVGQDVVFVVNSTAMSEATWGVRLGDTNDLKITFDRVFNPGGAFPDTKINSTSYAGRVSFVGDLTKGQAWFKITNLNINDTNNYMAKIRVRGTSFYKYIPAQLTVIKPPVTTEPLKTSTKELTTGVSSSQTSPRPTTSQVPQLSNRSMSINVVKDVVGDFSDSNSAAFKQFSENFVSEINSVYKNIHIFEKAKVTSLSENIIPVKFVVYFKSTIKPDEICGPLKDAVKDNRLGSLKIVPGSLGCSNDPNTSFPKKQSNSASTCTSIIVACVTVNIFLILVVVFLLIYIWRLRLNTEKRAGIRNSSSIQDKNPEANENVHPMEDTSQGMTTKTARTPNAEKELYETINENRVKNNVAIATTVKHTSGPSVGVQGDAPSFPQHYQELQRKAPNPTPLYEPLKQQGVSNKEELASEGPKTYEQLQQSASGREYQSLKSHKDTESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRQ6</accession>
    <name>A0A6P8HRQ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116292211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555335.1">
        <property type="nucleotide sequence ID" value="XM_031699475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRQ6"/>
    <dbReference type="GeneID" id="116292211"/>
    <dbReference type="KEGG" id="aten:116292211"/>
    <dbReference type="InParanoid" id="A0A6P8HRQ6"/>
    <dbReference type="OrthoDB" id="10401168at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="5">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555335.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20918" checksum="2A78506E734BEC55" modified="2020-12-02" version="1">MVCITNDDKVEFDFLYSNMTVEENMRYISIPINKTGRSAIPVNFRLTMDDKSYSTAIRGVDYEDRHGNIITFPASDQQLSTMYVNVTIKMDGKAESSEVFSVGLEAVDSSTSTIGSKNTMVVKITDKKDNDDFAAREMQRDQDEKKRTDTLFLILYLTVAFAAVIIIILIMICVLIIKKLKKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRT1</accession>
    <name>A0A6P8HRT1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xaa-Pro aminopeptidase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555402.1">
        <property type="nucleotide sequence ID" value="XM_031699542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRT1"/>
    <dbReference type="FunCoup" id="A0A6P8HRT1">
        <property type="interactions" value="1619"/>
    </dbReference>
    <dbReference type="GeneID" id="116292260"/>
    <dbReference type="KEGG" id="aten:116292260"/>
    <dbReference type="InParanoid" id="A0A6P8HRT1"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000001">
        <property type="entry name" value="Putative xaa-Pro aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000004">
        <property type="entry name" value="xaa-Pro aminopeptidase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="327"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="555"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031555402.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="69673" checksum="5DC6FD2A1BA52218" modified="2020-12-02" version="1">MMEKSSRQILQQLRSLMKNKTHVSETIQAYIIPSGDAHQSEYLAECDLRRGFVTGFTGSAGTAIVTEHKAALWTDGRYYLQAEQQLDANWILMKDGMLDTPTKEEWLIQELSSGSRVGVDPFLVSLQEWQKLSKAMTSNGLSLVKTETNLVDIVWSSHDRPAPPSDGVTALSLNYAGKSWQQKIKELRETLKKKKAYAFVATALDDVAWLFNLRGSDVEYNPVFFAYAIVTLDGISLFIDETKLDAAVRKHLGLNGVFENDESLHITIREYTTIQNAVKEIAESDNKIWISKTSSVALTSAVPKLNLIDDASPVAYAKSLKNDVEREGMRQAHIRDAVALCEYFCWLEQEVPKDELTEITGSDKLEELRREQEDFVSLSFPTISGVGSNGAIIHYRPTEETDRMITKDSLYLCDSGAQYMDGTTDVTRTVHFGKPTRHEQECFTRVFKGHVALAMATFPNKTSGHRLDMLARKALWDVGLDYQHGTGHGVGAFLNVHEGPQSISSRPKPDEVPFEAGMDITIEPGYYEDGKFGIRIENVYIVKQVELKNNFQGKGFLGFEPITLFPIQTKMLIPSMLTPEEIDWLNNYHELCAETVGAVLREQGKHQALNWLLKETRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS03</accession>
    <name>A0A6P8HS03_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Muscle, skeletal receptor tyrosine-protein kinase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116292282</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555425.1">
        <property type="nucleotide sequence ID" value="XM_031699565.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292282"/>
    <dbReference type="InParanoid" id="A0A6P8HS03"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF614">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028110089" evidence="14">
        <location>
            <begin position="29"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="17">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="16">
        <location>
            <begin position="60"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="317"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="593"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="724"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="19">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031555425.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="88107" checksum="EDC1BE35AE3ADFE7" modified="2020-12-02" version="1">MIYCSKSSLSKICVLLIVKCVLFTALDCTQITLEEKVACSITRPNQTTCVGMGCCWDPSNSSMKCYTKKGGQCILYPGNSCKVTINTTLLPHRETPRFLDNKLGILGTESFLKLVIGVIDSDDYVTDLNCRKILSTMLCHYTLPPCKPDGTIRPFCQEDCIAIFKRCQESLNQVIGAVKHIAKSKQIDFIHTGFPNCSRYKPSTSYDMSSNDSCVKTGFFNFTTRESKRGEDDGTNLAAIILPVILIVLLVVFVVAIFLWRRKKQRKNAMKNGRLILGEGALTMRQKLRADSLKSLDSRMLRLYDPSKLKHYPLDHVEYLKDLGEGHFGKVFQGRAVGIIERQPKKELLVAVKALKEGSSKELKEEFYQEVALMSIFQHPNXVSLIAVSTEEEPYGMIFEYMTEGDLNHYLRMAKPAEVSVEQGPDDAKVFLSQQDLVHIVEQIAAGMEHVAKLKFVHRDLAARNCLVGKDLLIKIADFGMSRDLYQSDYYKMSRETLLPIRWLAPEAFLYGKFTVMSDVYSYGVVVWETYTFGLQPYYGYTNKEVTEFIKKGIHLGKPDYCPDYIYNIMKDCWAKDPRDRPDFEDIQKRLRDPFGNYDMPKSNPDSLNEQSDEGSHGDEKDRVDAGSPDFGNYDVPRSPLSSRDDIDKEDKDVPKGDSEFGAYDVPKDNEFGAYDVPKDNEFGAYDVPKDNKFGAYDVPKDNEFGAYDVPKDEFGAYDVPKDEFGAYDVPRSPPNGGGYLRDRHEEDESDNEGPNTWDPTDKKRSTISLPVENSIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSC3</accession>
    <name>A0A6P8HSC3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ryncolin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559279.1">
        <property type="nucleotide sequence ID" value="XM_031703419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295570"/>
    <dbReference type="KEGG" id="aten:116295570"/>
    <dbReference type="InParanoid" id="A0A6P8HSC3"/>
    <dbReference type="OrthoDB" id="5974161at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559279.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19848" checksum="8B725AE25421D093" modified="2020-12-02" version="1">MTTDGGGWTVXQRRQDXSVDFYLDWQPYKTGFGNLNGEFWLGNDYIHRLTARTPSTLRVELEDWVGTRKYAKYGSFSVNAESDKYSLSVGSYSGSAVDSLSYHNNMAFSTKDRDNDVHSGNCATTYTGAWWYHDCYHSNLNGRYLGNVIDNKGVRWYSLSLKFTEMKIRPQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSD6</accession>
    <name>A0A6P8HSD6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116292412</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential for normal male fertility and for progressive motility of spermatozoa.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with HYDIN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555592.1">
        <property type="nucleotide sequence ID" value="XM_031699732.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HSD6">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="GeneID" id="116292412"/>
    <dbReference type="KEGG" id="aten:116292412"/>
    <dbReference type="InParanoid" id="A0A6P8HSD6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000040">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF62">
        <property type="entry name" value="KINESIN FAMILY MEMBER 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 16" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10 15 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="19">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="494"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031555592.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="86710" checksum="D289D0985E4F14C4" modified="2020-12-02" version="1">MSNNGRVKVFVRVRPSAKFAEDMIELLPDGKSVNIHCKKDQRRGYINNQVLDWGFSLDRILHNAXQEDVYEECAKNILLSTLDGCNGTIMAYGQTGAGKTFTMTGSTERFEHRGIIPRAIQQLFKEISERPENAVTVRISYMEIYNECMYDLLATLPGVMPLEPGMMVVTEDNNGLTRVKGLSIHTASNEEEALNLLFEGETNRIIAQHSLNKHSSRSHCIFTIYIESHSRIESNTKYTMSKLNLVDLAGSERLGKTQSQGSTQVEATYINKSLSFLEQVVIALGDPQRDHVPYRQSKLTHVLKDSLGGKSNMLLIANVWGEAEQIEETLSTFRFGSRMTNVPCEPAVTEYHDSNKLCKEYEREIIILRKELAMHDTLTNRSQISYEPLSESQILEVRDQVKSYLAGELNDIDLVNVRQIKETFAQFKAIVNSIEVDMEEKLKQKYVLQERAGVTSAGTGKLGTTYEXESGLVGEVDPRGFGVGVAGGNVKPNVTALVSGKRNKSRKSRERESAGQKSQAGGGRSDVQEKPSSPIPSESSLSPPPKSTAFEDFKKERGSEINRILNENKAILKAKRQTAKDLSSTINNLKDEIDQEAVTLEKKTEEKMKDGDFTIENGQVVIDEDEFQHVKKIKELKAKYRENYDELQNLKSEITYCEKLVDQCRQRLLSEFDSWYVESFLGPDEQITSSVPGVRKVSREGYVPEDEQEKFDRLQLELLMEHPDSVPYYNAKMQTERRMHLTSSGPRRNKPGAVVATIRNKPPSTLTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTG5</accession>
    <name>A0A6P8HTG5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Uncharacterized protein LOC116295873</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116295873</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559689.1">
        <property type="nucleotide sequence ID" value="XM_031703829.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295873"/>
    <dbReference type="KEGG" id="aten:116295873"/>
    <dbReference type="InParanoid" id="A0A6P8HTG5"/>
    <dbReference type="OrthoDB" id="5977355at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15137">
        <property type="entry name" value="7tmA_Relaxin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000393">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
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        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027680505" evidence="15">
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            <begin position="25"/>
            <end position="2755"/>
        </location>
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            <begin position="2170"/>
            <end position="2189"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="2201"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2256"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2288"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2342"/>
            <end position="2370"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2391"/>
            <end position="2413"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2425"/>
            <end position="2446"/>
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        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="18">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
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        <location>
            <begin position="767"/>
            <end position="844"/>
        </location>
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        <location>
            <begin position="995"/>
            <end position="1153"/>
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        <location>
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            <end position="1309"/>
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        <location>
            <begin position="1324"/>
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            <end position="1418"/>
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            <end position="1667"/>
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            <begin position="2180"/>
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            <begin position="2508"/>
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            <end position="1355"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_031559689.1"/>
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    </evidence>
    <sequence length="2755" mass="312218" checksum="F5B9218886B8657E" modified="2020-12-02" version="1">MFQWQLNILQYFAWFLLFLLPTDAVSNNTSPSFGCQPDWLRHGNSCYYFSTVSRLWAYGDAWKPSTTMCIDQDADLAIVDSPEKLQFLTSIAHDLKLSDVFVGSRDTIKVSWNWSQGPAVNVSLWGPGVSPKGKCGGLLRKSTWCGWWWVDLPCDSRRYGYVCEIPLVSNNCSSGMNLKFGNTCYTLNPNPKKTWVQAQTSCSHVGAKLAVVDTEEKRAALSKELDKITTKPLYIGLVRDMSDWSWINGEGVNESLFQAGSTIERKDEPQCLAIDASRSASSGLIAISCKFIYKSWYYVHDYICEKNEVNIAEGSYLEYSKTDNNTQVRYIVDGNPSTCVRFIVERNTWIKVQLERKTYIYKVKIIVSSNKNQSESTFEVQVEASFPYSNNKTCSCLGFRSKDIFYDCKPVIQSSAVIIKSNRVGSTLSICEIQVYGAGTSTDLQGVLRNVWFHDFETKSLREYLKTKLQREFPHNMRIMKNLQMSYELGDNSVQLLSAYLTVFENGEYNFLISCNTQCEITLGVAVEQVFEDDSPESLLLDLRYHTSRIDWNRYYKKHPTSIKLSVCRIYHMNTYVKHNYVTVGLKYPDGKLSVPVPNKHLYWTQPGERSFRFQMLPKINFVEVGKELVLQASYRYCCHGIRCPNCSLNVHLHVFNSSSSVQSSILMDCKEHPWSTAINATVQPGNHSIEVSYHFLQDKDLPTIRRTVGYAIVNETTLLRCAFTDKDICGWKRNKTIVVTDNSLSTTFLKSDNLLWNDIYQAIGACLSFSYKLDSPGKGKRLDVYLSIKGEMILLWRLSGFHGYMWTKALVSWRPQRDSKLVFKTIGEAAISEVLVTTSMCRTKPPYAKPGYTCSEEEFQCDNYQCIKKMFVCDGDKTCLDGSDEENCVCLRSELQCASGICLATDKLCNGWDDCIERSDEKTCERRNTMLEFQCVDGTFVPWSVTCREGSYCKDGSHSPDICGHSQCPLNNLACNKTNINNPLVSNCDNTFPTHCSLEDGLCGLTFNASEALKWTRRNGPTLTPNTGPSFDHTTLSGLGYYLYVEASNETKGTKARLHSRWFPGNQPVCFRFWYHMFGVDIGLLNVIEMTDSSSSIKWSQKGDRGNRWLFGQATLLAGKPYKFVIEGVIGDGVYGDIAMDDLGVTEGACATIIEQSPPNCDFESDLCSWHGDNEWSLSKSTMNVQGVASPDTGGFLFLLQEQSYTFTHCISSPPLRLQDNWKCLMFSYYIGATDTYFTHNLNVLLQNKNGSSTKLWGTPHATNKWIYVQVPFFTSENGDQVKFEGTLSHSAVIAFDEVTFSKTSCHPIPYHADECSVLTYDRNDKCCWFPFIYENTIYYDCDTTDPKDPQPWCLVTSEFKNFDYCDGYCPWRTIDGRCCLFPFLYDGKKYSSCMTLNNTRPWCMTNLEGGWGYCQGECNTTEELCRWKTEQPDNRINWFLXSALDVHREITNIAKTKPNNRKESRHTEQFEVHLPLSQFGNISINSAINDRIDAVTLCVWMTSQTGGLRVLYEIPDGCGMSVAMGIHMDTNVMISVLGRKWNTGFSVNDGAWHHVCLTWRSAGGTLKAYIDGRVSLREKPDQLDALIIPEGGTFTTSMFDTTGKNDLDVKGKISGVNIWSREMNEFELLAMSIGCVQENGDLLSWNTILKEIKNSNLKIGPAGCVYSGADHFIFATNSSRFSSVLNSPWYNRSTFGHTQCLRFRYIVYGPGAVRLRVMHRYYSSHAFVPVLDVANNDQSWWQYAQTSVGSVENYQLSMEASFNERSGFIVISALYLLDGSCSKKPQQNQALEVTLTQMSGIITSPFHPGYHDVDTTNIWVISASRNHLIRLKILAFDLEYHDKCAKDYVELFDGGSVTSTRIGRFCGVLYPPVIESTSNYMTIRFRSDSSVVRTGFKLSYAWKSVKSKMHACTLKGCSYDTKCYVTSNDESGEVVVESRGQSLEVLPVIPKQTSVLLLGGNRLPILTKSHFDSLSSLKYIDLSGNFILNTNDLAFANMSSVKVLRLNGNFIRSFPKLASLPRLHTLDLGANLLSNITRYSLINLPSLRILSLRMNEITELEDGLFTDMPGLQYLYLDHNNIKKLTKNTFKGLKALQILNLQNNKLSEKDLTSDVFENLRNLRQLKLDNFILCCYARRSISEALRCESPSNEFSSCDDMMKNSAVRVCLWILGILASVGNLLVVVWRFKVRDENKVQSLLLTNLAIADFFMGIYLLILAVKDIQFKGEYYKHDVEWRSGTTCQFAGALSLLSSEASVLMLTIITADRLISVVFAFKIPRLSLKVTCILCSVVWIFCLIISFLPIFGLDYFEDEQYGFGFYGRSTVCLPLQLSSQRSPGWEYAITFFIVLNLGAFVFILVSYCAIFWTIMRMSRSSATKHMRKETSKAARLFFIIFTDFCCWMPVIILGILSITNSFNDPKGTVYVWIAVFVLPINSSINPILYTFSTDYVKSHLPSLSLFSSFSNYQTSYSRNRGSRAADDISLQDKEEPKHTSNNLPKVIVTSNENDLVKELNILEEWNIFPLTDVDEIVVFVSAETKSEEKVLVKYFGEKNLEDWKREVAVHTVLKEYGSHNNVMSCXWNADSESSSLIKIVTNVSSIPSKAWLICYTYSSSKTLKDFCETQGECDLLCNVVLDVISGLEFLHGNGICHNFINNQSILIEDKTGIPRFKAVIGDFRNSFVLTENLELDSFKHXLEDVKQLGMLIDWFLNMCDEQSTNEIRGLLAMLRSDNNSVEILSSWRQTLLRWDFSSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTM9</accession>
    <name>A0A6P8HTM9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116292838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556055.1">
        <property type="nucleotide sequence ID" value="XM_031700195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTM9"/>
    <dbReference type="GeneID" id="116292838"/>
    <dbReference type="KEGG" id="aten:116292838"/>
    <dbReference type="InParanoid" id="A0A6P8HTM9"/>
    <dbReference type="OrthoDB" id="9799930at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031556055.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13228" checksum="507DD3FAE9CC9438" modified="2020-12-02" version="1">MSGRGKGAKSRAKPKSRSAKAGLQFPVSRVHRFLRKGNYSKRIGSGAAVYLAAVLEYLAAEVLELSGNAARDNKRRRIIPRHILLAVRNDEELNKLLSSVTISQGGVIPNIQAVLLPKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU02</accession>
    <name>A0A6P8HU02_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dopamine D2-like receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116295120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558718.1">
        <property type="nucleotide sequence ID" value="XM_031702858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU02"/>
    <dbReference type="FunCoup" id="A0A6P8HU02">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="GeneID" id="116295120"/>
    <dbReference type="KEGG" id="aten:116295120"/>
    <dbReference type="InParanoid" id="A0A6P8HU02"/>
    <dbReference type="OrthoDB" id="5970330at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031558718.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34866" checksum="52EE483F42AAEA2E" modified="2020-12-02" version="1">MALNISKGCFFDPENSLSTKETKILMVLSILSCVLAIIGNGIILFVVYKKESFQNTSNFFLCSLAVADLLMGLIGNPIRTVFLGINLWTSNRNSLTKFNDFLACQLLVATAFNLCAVSVDRLVAVKWPLRYPTIMTSKTTLRIIKLIWLSSFGFGIPMLIFNDGKNACIYWLFISLLTLVCPLLVILYCYTAILKIAQQKQKYVVPQIYMSSFPSASKETNKYRKNRKAVATFLMILTVFVVCFVPNAVCSVLCVIPYQKCPAFAQTLVNKWEWYIFLLLATSFVNPLLYGLRNRQFRTAFFSLVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWB4</accession>
    <name>A0A6P8HWB4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116295846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559663.1">
        <property type="nucleotide sequence ID" value="XM_031703803.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HWB4">
        <property type="interactions" value="1901"/>
    </dbReference>
    <dbReference type="GeneID" id="116295846"/>
    <dbReference type="KEGG" id="aten:116295846"/>
    <dbReference type="InParanoid" id="A0A6P8HWB4"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559663.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20350" checksum="483C7B2BACB273E0" modified="2020-12-02" version="1">MANKILSKKTTNKWAIDLTGRPKYVPDRQFQLXASDLPAPLGYTENRVQHEPRDLNSTHLVAKKTWDIALGPFKQIPMNLFIMYMAGNSISIFPIMMVGMMFLRPVKALLAIKSTYKAIEGDHDSAYLQKIIYFLGNLSLVILALYKCHSMGLLPTATSDWLEFMERKTRPEFSGGGIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXN9</accession>
    <name>A0A6P8HXN9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116296272</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031560138.1">
        <property type="nucleotide sequence ID" value="XM_031704278.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296272"/>
    <dbReference type="KEGG" id="aten:116296272"/>
    <dbReference type="InParanoid" id="A0A6P8HXN9"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000262">
        <property type="entry name" value="Serine/threonine-protein kinase Nek8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025592">
        <property type="entry name" value="DUF4347"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051997">
        <property type="entry name" value="STK_NEK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535">
        <property type="entry name" value="PROTEIN CBG16200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44535:SF5">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14252">
        <property type="entry name" value="DUF4347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="224"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="544"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="596"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="648"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="700"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="768"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="832"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="893"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1040"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1109"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1267"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1345"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1153"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1356"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031560138.1"/>
        </source>
    </evidence>
    <sequence length="1373" mass="151623" checksum="B9C5B480C107CFE3" modified="2020-12-02" version="1">MATVAKQDSKTDLTEINNNVESQEKIVNRVGSAGSNTTWRLVLLSSKIRQSSVLSSATRSGVRILSYKYDSTTLESLLAQVQQTLGEKRVESIGFIANGQQGTLQLCANGDQVISLRTLKEQGDIRNFFTQIVSTCLDSTSSGAGLDFLACPLAQSSDVIQVLDLLENLTKVSVGMTKELMGADVRSNPNNNDDNTSSFPGDLYFKSEKMRGWSGAQPQSISNFEKIKTVGKGAYGAAVLYRKKDDDSLVILKEITLHDLNAVERQMAMNEAKVLSKLSLHPNIISYYDSFEVDGTLMIEMEYADGGSLDQYLMRLDKDMDEKDILIMFQQMLSALKYIHDNNILHRDLKTANIFLTKDTVVKLGDFGISKQLEGSKANTVLGTPYYISPEMCEGKDYNQKSDVWALGCILYEMASRQKTFEGSNLPALVNKIMKGQFAPIRGNYTPEFRNLVKDILQKEPELRPSVTDLLYERVPKLLARYDDPTEDELSSSMEQNMRKKTRSLFFYLDMTTVSMYPIETPVRAQLGEVAVGTSHVTVVTLEGSVYTWGDNGCGQLGQGDLINRDKPTLVESLKGKSITRVACGDNFSVFVTDNGIVMTTGSGEQGCLGHGDWTSISRPKLIEGLLSVDVTAVSCGPHHVAVVCSDGLVFTWGKGADGRLGLGDEENHCVPCQISLEVPVSIRDVRCGTDGTMFLTDTGALLACGSNANNKLGLNNRQGFLMQMKNLLNKVQVEVKKNPTAVKALSRYRVIDVALGPTHSAVLVEPGHVYTFGANSEGQLGCGNTKPRDAPATVKPLEEKTVTMVLCGDGFTVVGTNDNTLFYWGCRPSRRQRKASENGDKTDTETASLKKHKRNASGSMSIGSSDSLDYSSGNNNGLGSSQTFAVRRDGVLELSQGRTERGRKEGVQEGMAMPLSQKKRKDAVHEDSTGALDLMDSCASLADNTNTSLALSEFDFQDNNGSKEIAKNYIRMSSRKGRLNGQVGMGSLRMHDNEPVCTPISLFHWDAICGIDDNDSEYPVYLQDISGYGENIFIQIETAAPPPRKRSKKRSCKKGNEKKSSKRVNESQNSSRLGPALDSSVGSSSSEMEALGEAPTWIRNELKEGIIASEAVDDDADSEEETDSDGRTDSEIEDGDDGEQDKNKSLKKTGKSRNIASHNMDLSHNHVLTVKKRTGPPSPLASRQTKSIASTRPERPHDTRRPVGRSRFSQAANRARPGPSRQVDYKGKMNTDLRTLQTRHEQVVSELQRDAIEAQLALKQEIEKLKDEKEESEQQLKQYQEGESKRLEQWKAQQEQESKEKETRLTEEVQNLKTELLKQYGKLQDNYNVVISLQEQLARLQQEQLRQQAKEKRQNSSLVNQNKAKSSVCSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXP1</accession>
    <name>A0A6P8HXP1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dipeptidyl peptidase 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560126.1">
        <property type="nucleotide sequence ID" value="XM_031704266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXP1"/>
    <dbReference type="FunCoup" id="A0A6P8HXP1">
        <property type="interactions" value="2495"/>
    </dbReference>
    <dbReference type="GeneID" id="116296264"/>
    <dbReference type="KEGG" id="aten:116296264"/>
    <dbReference type="InParanoid" id="A0A6P8HXP1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000016">
        <property type="entry name" value="Dipeptidyl peptidase 8-like isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045785">
        <property type="entry name" value="Dpp_8/9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19520">
        <property type="entry name" value="Dpp_8_9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Dipeptidyl peptidase 8 /9 ,N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="6">
        <location>
            <begin position="168"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="5">
        <location>
            <begin position="650"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560126.1"/>
        </source>
    </evidence>
    <sequence length="851" mass="97137" checksum="CF12E19F08BDA8DA" modified="2020-12-02" version="1">MFDGSSDNENGQTPLTMDSLLYYYMKTKRSWKDLQYAVRTSRSVQQKLINRIPSNFTFSGDRLYFLAVPPNSRENTIHYVDIPGHGASCVGECLEWQPLLDINRPFVGYSKEEQLMRERKRLGSFGITSYDYCNMSRRFLFSSSNSLHTFIDIGKDKENCQLPFSVHEVPSQTNDTKMDSKLCPINSNLAAFIHHNDIWVTNLETGQELRLTHSNNGSTNPIEETTSSGVASFVAQEEFDRYTGYWWQPQCFIDENKTISYKILYEEVDESNVEVLNIVASPEGATQISSVDSYRYPKAGSSNATSKMKIVEFAIDQSGQMCDTVMVYQLMVPLDEIFPNMEYVVRAGWLPDGQSVWVQLLSRNQQHMTMVQIPLACFSHIVPSEFDLISSSDSLPLMKVIAEDTTDIWINLSDIVYFLKNATSETQFIWSSESSGHRHLYLATVNSRHVMSRGRSRSFLGQNSVYYPLVTQQQLTDGDWEVDGKQIWVDESRKLVYFMATKETPLEQHLYVVSYDDRVEKTIQRLTEPGAYHTITMNEDFTKFVSLSSSVNETHKAVVYQIDNDEVSVNNIPMVTIEPIATLLKSEAIGAESCPPEIFSYQSKQGHQAYGLICKPLNFDPGEKYPTILYVYGGPQVQLVTNSYKGVRFLRLHTLAMLGYVVVVIDSRGSSRRGLHFEGHIKNRMGKVEIEDQVEGLEYIAKTTNCIDMSRVAIHGWSYGGYLSLFGLIQRPDIFKVAIAGAPVTTWEAYDTGYTERYMWIPQENSRAYMMSSVLSYVNSFPDEENRLLLVHGLIDENVHFTHTSLLINELVKACKPYRLIIYPNERHGIRQTVSSEHYETSMLSFLQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYI7</accession>
    <name>A0A6P8HYI7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116297364</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561439.1">
        <property type="nucleotide sequence ID" value="XM_031705579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297364"/>
    <dbReference type="KEGG" id="aten:116297364"/>
    <dbReference type="InParanoid" id="A0A6P8HYI7"/>
    <dbReference type="OrthoDB" id="5989327at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561439.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14180" checksum="A71FAC2B650EFA80" modified="2020-12-02" version="1">MWKKLGAGEMEAYTRRAEEANQNPAAQKKESRSKRVKRLSSVIRDSIEQLNDLGCPSLXIGLFDGVPERYFANGVGMLARDEVFMNYTVSSLVKSVAQEKMEEKSAXLSAEIEQKKKTIKKTKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZW9</accession>
    <name>A0A6P8HZW9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vesicular glutamate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116296854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560821.1">
        <property type="nucleotide sequence ID" value="XM_031704961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZW9"/>
    <dbReference type="GeneID" id="116296854"/>
    <dbReference type="KEGG" id="aten:116296854"/>
    <dbReference type="InParanoid" id="A0A6P8HZW9"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="83"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031560821.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33078" checksum="51921676B58D383C" modified="2020-12-02" version="1">MTMPITGLLTKYGFDGGWGSVFYCFGVFGLLWYMVWLLFVHETPEQHPSMSVEERELLSHNDKDLNKVGKVNVPWMSILKSLPVWAIVAANFSLDWAFYVLLISIPKFLVEVFDTEIHKMGFMAAAPFLVKGICTPVAGLSADLLRKYTWSTKTVRRCFYAVGTLSTGAFILIAGYTNSVAVVVVCMAISGASTSLSYPAYTVNMLDIAPRCAGVIMGLCNTLGTTAGFISPILVGFVTLNQTLEEWQTVFWINAILMCIGTGLFCSFLEGDRQAWDVVEDSNDDSVDSSKNIEAFEPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZZ7</accession>
    <name>A0A6P8HZZ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran-specific GTPase-activating protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560846.1">
        <property type="nucleotide sequence ID" value="XM_031704986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZZ7"/>
    <dbReference type="FunCoup" id="A0A6P8HZZ7">
        <property type="interactions" value="2397"/>
    </dbReference>
    <dbReference type="GeneID" id="116296877"/>
    <dbReference type="KEGG" id="aten:116296877"/>
    <dbReference type="InParanoid" id="A0A6P8HZZ7"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000136">
        <property type="entry name" value="Ran-specific GTPase-activating protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF94">
        <property type="entry name" value="RAN BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560846.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25172" checksum="11324AD8D63F90D7" modified="2020-12-02" version="1">MSDETTHEPPANPEIHFEPIVSLPKVEIKSLEENEEEIFQMRAKLYRYDKNGEESEWKERGVGVIRILKHTDKNTYRILMRRDKTLKICANHLITADMELKPNCGSDKAWVWSVAAEFADEECKSETLAIKFGNAENAKKFKDKFEECQKALDNKDSKSEEPESDKLAKELEGLNVKESKDTETVEEKKDTNEPSTSSKTEKDDKKDEKNDEEDVPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I277</accession>
    <name>A0A6P8I277_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295346</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031558997.1">
        <property type="nucleotide sequence ID" value="XM_031703137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I277"/>
    <dbReference type="GeneID" id="116295346"/>
    <dbReference type="KEGG" id="aten:116295346"/>
    <dbReference type="InParanoid" id="A0A6P8I277"/>
    <dbReference type="OrthoDB" id="10316385at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558997.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="30800" checksum="6CF611C4E0D6E95B" modified="2020-12-02" version="1">MPNRATPVVSVRSARCSAIMILILGILFDLTASVYFGFNIYFYLSTSYAFQLSSMGAGGKLYWRWGYPLLIGTLIQVTGCVGLCASNPRRLRNKCRTATFCIFSIVLIGFESYIIDAFKLELTVFIRNFKAGACNEIYCYVYLSSYGSFVFLAALILINCIWCVICCLGSLFCMPGEHPRAQDGEQQPTTAQDMMMQETQPSMYNNPALQASTENLQGNAPMAYGSGPPTNPTMQGNMPMQGNAPMACGSGSSLYPKVPGNMQSMQGSATPMAQATSGEKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2M7</accession>
    <name>A0A6P8I2M7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanidinoacetate N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116298450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031562789.1">
        <property type="nucleotide sequence ID" value="XM_031706929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I2M7"/>
    <dbReference type="FunCoup" id="A0A6P8I2M7">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="GeneID" id="116298450"/>
    <dbReference type="KEGG" id="aten:116298450"/>
    <dbReference type="InParanoid" id="A0A6P8I2M7"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030731">
        <property type="term" value="F:guanidinoacetate N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000096">
        <property type="entry name" value="Guanidinoacetate N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562789.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26695" checksum="4CE8DECE04330D20" modified="2020-12-02" version="1">MSCTKIFSEGENCKTDWKAASADYDNTDEHLTIMGKPVMERWETPFMQKLASIAASRGGRVLEVGFGMAISATKIQSFPIQEHVVIECNDGVFERLQTFAQNAKHKVTPLKGLWQDIVPKLDDNSFDGILYDTYPLSEDTWHTHQFEFIKNHAFRLLKPGGVLTYCNLTSWGELMKGKYEDLETMFQETQIGYLIESGFKKENISTEIMDIKVEENCKYYAHNKMIVPTVIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4H8</accession>
    <name>A0A6P8I4H8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOB-like protein phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562371.1">
        <property type="nucleotide sequence ID" value="XM_031706511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4H8"/>
    <dbReference type="FunCoup" id="A0A6P8I4H8">
        <property type="interactions" value="2104"/>
    </dbReference>
    <dbReference type="GeneID" id="116298135"/>
    <dbReference type="KEGG" id="aten:116298135"/>
    <dbReference type="InParanoid" id="A0A6P8I4H8"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562371.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27230" checksum="650A68594DE02F33" modified="2020-12-02" version="1">MAFVDVVQHPIIRRNRPGTKAKDMYKWPDEPFEEMDSTLAVQQYIQQQIRADYTNLNGILEPPEGQDEGVWKYEHLRQFCMELNGIAVKLQNECSPATCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAASLLNSNKYFPSRVSIKESSVAKLGSVCRRVYRIFSHAYFHHKTLYDEFENETHLCSRFTAFVLKYDLMAKENLIVPIEDAKTLTRKPSEDENTADHEESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4V9</accession>
    <name>A0A6P8I4V9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116296134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559952.1">
        <property type="nucleotide sequence ID" value="XM_031704092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4V9"/>
    <dbReference type="FunCoup" id="A0A6P8I4V9">
        <property type="interactions" value="928"/>
    </dbReference>
    <dbReference type="GeneID" id="116296134"/>
    <dbReference type="KEGG" id="aten:116296134"/>
    <dbReference type="InParanoid" id="A0A6P8I4V9"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559952.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31875" checksum="51F73BEB73B128D7" modified="2020-12-02" version="1">MRFAQLVMGPAGSGKSTYCDVIHKHCENIGRSVQVVNLDPAAEHFSYPVAVDIRELVELDDVMEAEDLKLGPNGGLIFCLEYFVKNLEWLQEQLGEGDEDYILFDCPGQIELFTHLPLMRQLVETLQQWDFRVCGVFLIDSQFMVECSKFFSGILSALSAMIQLEIPHVNVMTKMDLLSKKQMQDIERFLDPDPRVLVHELGDGMNKKFWKLNEAIAQMIEDYSMVCFLPLNSNDEDSISQVLDQIDMAIQYGEDTDVRTKDFNEPDKEDDGLNDQDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4Z6</accession>
    <name>A0A6P8I4Z6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116298297</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562551.1">
        <property type="nucleotide sequence ID" value="XM_031706691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4Z6"/>
    <dbReference type="KEGG" id="aten:116298297"/>
    <dbReference type="InParanoid" id="A0A6P8I4Z6"/>
    <dbReference type="OrthoDB" id="6019741at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000098">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="208"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="24">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031562551.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46503" checksum="37FE21260E1363E8" modified="2020-12-02" version="1">MILLGYDTKVRPNYNGAPVEVYTDFSVASFGSFDEVNMKYSIDMFFRQSWTDNRLRHRMNETLTLTLGTKHPADFIWVPDTVFMDASTAHMHTVMVNNHKLDIDPDGRILWGSRATVTARCYMNLHRFPMDEQSCPLRAISYAYPVRHLVYRWKSSPGVKVLNGEMSQFYLSKIETVLRNEEYVAGEYSVLVATFSFNRRIGFYLIQVYIPCMAIVFVAWMSLWVDRKATPARVSLCITTLLTISTIWGNVNVGMPRVSYVKSIDIYLMTSFVFVLGTLLEYVVVMKRHRIKLSCKLPELFRGRCRSSHSFTSDELPTHTIKMANIRRSTSTPSTVNNDINIYGMFDMKYSNGPIKCRRSKKKCEEAKDSSIVDIYARIGFMLIYIIFNAIYWAILFLPPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I785</accession>
    <name>A0A6P8I785_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116296645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031560555.1">
        <property type="nucleotide sequence ID" value="XM_031704695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I785"/>
    <dbReference type="FunCoup" id="A0A6P8I785">
        <property type="interactions" value="2383"/>
    </dbReference>
    <dbReference type="GeneID" id="116296645"/>
    <dbReference type="KEGG" id="aten:116296645"/>
    <dbReference type="InParanoid" id="A0A6P8I785"/>
    <dbReference type="OrthoDB" id="9981542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="319"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031560555.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="52125" checksum="50317BBA0E022237" modified="2020-12-02" version="1">MADEQESSTDIFQDLDSLVWGPNVKEEVFQRWTRGFIFSPDEPTALVQEQGGPCAVIAAVQAYMLKNILFCDGTDASSTDWKHLSDDQTKNILVCTLCQMLQMAKEEDDSIISLVLLRDHMLSNLKEHSSIETDDGTSTCRNSESPQYHKSVCEQQLKHQSNKETINLLSQTQCNSSSEARSLIERNIHIFEGHFGILLFLYSMILTRGISTIKDEMGDPGEPLVDENFGFGSQTLINLLMTGQAVSNVWNLSKEVSGLELKGIAKQSQVGFLTLLEAHRYCEVGSFLKFPIYPIWLLGSETHITVLFSTNQSLSGPESPKEEAQRVFKSFDEQENGFIESDKLTDVLHKLGLETDPEYVTFMKSRLDPDSIGIILLPNFMDEFFPGESTSQWTGPFTVYHYNGLGVKQSDSQLPRKVMYSEGIACIEPTDLSHIAEEEIISCLKTKWTGITVTWHSKYPPSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I825</accession>
    <name>A0A6P8I825_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116300085</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116300085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564709.1">
        <property type="nucleotide sequence ID" value="XM_031708849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300085"/>
    <dbReference type="KEGG" id="aten:116300085"/>
    <dbReference type="InParanoid" id="A0A6P8I825"/>
    <dbReference type="OrthoDB" id="5977689at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031564709.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="52543" checksum="3E4E8313C6E871C7" modified="2020-12-02" version="1">MDSWDRFKEPLPPKERFYSTLNESGIKDEEYQHALDVWEKYSCENMGDYHDIYLRSDVVLLADVFQSFRKMAMKYYGLDPTNFYTAPGLSWSALLKKTNAQLDLLTEYDMYRFMEDGIRGGVCGPSRRYARANNPTVEXDPEKPTTYIFYLGANNLYGWAMSQYLPVRDFEWDNIKPIEFYLNVGKEDDKGYVLEVDLEYPEHLHDAHDEFPLAPEAIEIPFKQLSPLQREMCPGYKSYRKLTMNLMDKKKYVVHYRNLQFYVRHGMRVTHIHRVLKFTQEPWMRSYIDFNTQKRXQAKNDFEKSLFKLMNNSVFGKTMENIRKRVSIKIASTIEEAEAYVSQPGFVRYVEMLNFYVIHMKKANLFLNKPVYTGFTVLDLSKLLMYEFYYDKLKPKYGDKCRLLYTDTDSLILEVQTEDIYEDCVPDNDEYDTSDYPPRVIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8M9</accession>
    <name>A0A6P8I8M9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116297028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561015.1">
        <property type="nucleotide sequence ID" value="XM_031705155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8M9"/>
    <dbReference type="FunCoup" id="A0A6P8I8M9">
        <property type="interactions" value="1677"/>
    </dbReference>
    <dbReference type="GeneID" id="116297028"/>
    <dbReference type="KEGG" id="aten:116297028"/>
    <dbReference type="InParanoid" id="A0A6P8I8M9"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000003">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000004">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="227"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="357"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031561015.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="68766" checksum="27FFC9F82337E536" modified="2020-12-02" version="1">MVEVTDEELQTEFEEFAVNVEDPAILDKLKEICHGCRLTAEDLVCQWISFAQTLTNQDLTIDVLEEFERKQLFESNKKNQTQFNKHEAPRMYTKDDLDNLLSPDEEDVDVFSSYAETPDNRKLLKKRIHTTPEVLTNKRHTSLTRTPGPMPFSPSSLSPAMATPSAKYASRRNAGESVCSFVPNGKTLDKDSWNGTGVTLDIDVADKEIALTERFKYMFQKQADKANVLNDMIDEMAERLKKEHGIEEFSNAASSNQVEINTVGMVCCDSVGKLNASSLMLEGSIDLSQGQQVKVDLSNIHQFALFPGQVIAARGLNSTGQKFVVNQIYNGVQLPFYSALDKNNDKLHKSSSPFSMMVVAGPFTTSDNLLYEPLNDLITVIKKDQPDLLILLGPFVDAKHEKIESGDLDETFEEMFTRQVVTIVGAIQRQQTKVVIVPSQRDVHHDFVYPQPPFVDKDNIFKDNKNAYFVSDPCSLLVNNIVIGITSTDVLLNLGSEETASPPGSSDRLGRLVKHLLYQHSYYPLHPTSEDINMDYEKFASHASLPCTPDILILPSDLRYFTKDILGCLCVNPGRLAKGQVGGTYARIYVNPNTEHTDKSLSHILSNSLAEVVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8S9</accession>
    <name>A0A6P8I8S9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tolloid-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564468.1">
        <property type="nucleotide sequence ID" value="XM_031708608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8S9"/>
    <dbReference type="GeneID" id="116299891"/>
    <dbReference type="KEGG" id="aten:116299891"/>
    <dbReference type="InParanoid" id="A0A6P8I8S9"/>
    <dbReference type="OrthoDB" id="5945145at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052129">
        <property type="entry name" value="Spermadhesin-Link_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908:SF8">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46908">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564468.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17956" checksum="BD0B318CBC61FA8A" modified="2020-12-02" version="1">FPEPDSTICSPFNTFYQNNNIQVSGSSGYIKSPLYGTKYPSNMQCTWVITVPNGNKIKLTFSDFRVGERFYGCSPSHDFVEIRDGEFDVSAILGQYCSSSRPSPVYSSGRHMWIRFNSNSDNYLDKQYAQEKNGFRASYEVIKLEEALQVVVKWHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8X0</accession>
    <name>A0A6P8I8X0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">LIM domain transcription factor LMO4.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12 13 14 15 16" type="primary">LOC116300313</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9 10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565013.1">
        <property type="nucleotide sequence ID" value="XM_031709153.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565014.1">
        <property type="nucleotide sequence ID" value="XM_031709154.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565015.1">
        <property type="nucleotide sequence ID" value="XM_031709155.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565016.1">
        <property type="nucleotide sequence ID" value="XM_031709156.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565017.1">
        <property type="nucleotide sequence ID" value="XM_031709157.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565018.1">
        <property type="nucleotide sequence ID" value="XM_031709158.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565019.1">
        <property type="nucleotide sequence ID" value="XM_031709159.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565020.1">
        <property type="nucleotide sequence ID" value="XM_031709160.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031565021.1">
        <property type="nucleotide sequence ID" value="XM_031709161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8X0"/>
    <dbReference type="GeneID" id="116300313"/>
    <dbReference type="KEGG" id="aten:116300313"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF13">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031565014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031565016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031565017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031565019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031565020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031565021.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17276" checksum="6AF48D656F246E2C" modified="2020-12-02" version="1">MTQKMDEQITNTGRGQAANMRICAGCGDKIIDRYLLLALDQYWHMNCLKCSCCEARLGEIGTSCYAKGGMILCKTDYVRLYGTSGACAVCAKLIPATELVMKVLGKVYHLHCFTCTTCHNQLVSGDRFHVVNGRLFCENDDPNLLKQLHAAKQTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I928</accession>
    <name>A0A6P8I928_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031564583.1">
        <property type="nucleotide sequence ID" value="XM_031708723.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I928">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="GeneID" id="116299981"/>
    <dbReference type="KEGG" id="aten:116299981"/>
    <dbReference type="InParanoid" id="A0A6P8I928"/>
    <dbReference type="OrthoDB" id="5990262at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="180"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564583.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35061" checksum="9DB05C0FFD491752" modified="2020-12-02" version="1">MSSFESKLQGSHHQLSSGYSTMDPSHGIILLIALVGSLIIKDVRRGKHDGRYTFVATNDVGSISTSATLFVYVKVTAHVPSRKYVFSLTTKRANLICYGRGFPLPNITWTKDGLPVSLNQTDRLINETFIESRLNLGHXTIDKAGRYFCHVGNDVHRQEPIRIAIDVFRGCPSAWKTYRGSNSCYRIVNTRTAKWDVARRSCISMGGYLVKIDSEEENRYVTKLASEASSAEIMWIGLSRISEDDFRWTDATILSGRYSKWNKGEPNNAKGNEDCVHLYVRDSHAPYWNDHICNYPEGKPFYTCEMERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I939</accession>
    <name>A0A6P8I939_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116299996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564593.1">
        <property type="nucleotide sequence ID" value="XM_031708733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I939"/>
    <dbReference type="FunCoup" id="A0A6P8I939">
        <property type="interactions" value="1059"/>
    </dbReference>
    <dbReference type="GeneID" id="116299996"/>
    <dbReference type="KEGG" id="aten:116299996"/>
    <dbReference type="InParanoid" id="A0A6P8I939"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031564593.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="16021" checksum="567DAE6A0CCFDB22" modified="2020-12-02" version="1">MSDGEQPTYVAFFGVMGATAAMVFSALGAAYGTAKSGTGIAAMSVMRPELIMKSIIPVVMAGIVAIYGLVVAVLIGSAIDPKEYTLFKSFVDLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILTTKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I973</accession>
    <name>A0A6P8I973_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561657.1">
        <property type="nucleotide sequence ID" value="XM_031705797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297551"/>
    <dbReference type="KEGG" id="aten:116297551"/>
    <dbReference type="InParanoid" id="A0A6P8I973"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561657.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20514" checksum="54C541766EA683F8" modified="2020-12-02" version="1">MADKLQXXXKLPSWIAFWLXLSSVICTIDALFVLLRPRTLPGGDLNYLVRPYNLYIEIDKRYIDLKDGFVIGQSWMNLVEVFFNAITLVLNAQSSAHSVVMALVVSTMTCSKTVLYFVISSKLCHGDEFIAQTSWSEHLLFYIIPNGTWILMPLLCIITLLLKISHAIEISNLASKQKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9G5</accession>
    <name>A0A6P8I9G5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297650</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561772.1">
        <property type="nucleotide sequence ID" value="XM_031705912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9G5"/>
    <dbReference type="GeneID" id="116297650"/>
    <dbReference type="KEGG" id="aten:116297650"/>
    <dbReference type="InParanoid" id="A0A6P8I9G5"/>
    <dbReference type="OrthoDB" id="5988866at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561772.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23691" checksum="3BC74D33220FDAA9" modified="2020-12-02" version="1">MILQAIEQRGRNWKSVLKFLCEHVDVLGKTGEFYKNVDVNDKRMQERIRKRAAKLLDGEKSQRMQLKTSIENEYYSAGDMDDDKQLHLAVGNENIDDELCEVAESIKQRDRKYVLNNQAAGSGSHVAQPKDVLNVIKRTAEKEKSEEQRKRKKAKKSSPTATVTSKMEALLDKLPQFLDTANKAAEAHSDAIEKWKKKNGLISDDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9I7</accession>
    <name>A0A6P8I9I7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptide FF receptor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116300071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564693.1">
        <property type="nucleotide sequence ID" value="XM_031708833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300071"/>
    <dbReference type="KEGG" id="aten:116300071"/>
    <dbReference type="InParanoid" id="A0A6P8I9I7"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031564693.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43334" checksum="5640A1D4097844C9" modified="2020-12-02" version="1">MSQSIVKPQLEHTSVDMEMPTSTVVFVFVLKFXFTWFGVLENLIVCYVMIRSKRIWKNMSNFLIFHLSFTDIVFRAVISPLEMNLVTPDVNSSSDGQIQCRTLNFMSRTCSAAIFLTLLAISIDRYRNILSPLKARIQKQRRALAVGLVWLCAGAASVWFIPSTDVIIARFEKYQDFENTTGAEYESKNMCLLRKGLKTQVALTLYFTTAFAIPLVLITVLYTRIIIYLWRRSKKGMISGQVAFAKSKSIRMMAIVVFGFALTSGPVIIVDMLFYFFSSETLNDPKKHVLATSGANLLQHCSSLINPVIYCFYSEEFRKDAVNLCFCLCRKWKFLSLRKKLGICSERGSATDVSQKGGCLLGISEQKSTSQSQITLQEKLDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAA3</accession>
    <name>A0A6P8IAA3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myeloid leukemia factor 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116297534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561640.1">
        <property type="nucleotide sequence ID" value="XM_031705780.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IAA3">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="GeneID" id="116297534"/>
    <dbReference type="KEGG" id="aten:116297534"/>
    <dbReference type="InParanoid" id="A0A6P8IAA3"/>
    <dbReference type="OrthoDB" id="5983898at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019376">
        <property type="entry name" value="Myeloid_leukemia_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13105">
        <property type="entry name" value="MYELOID LEUKEMIA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10248">
        <property type="entry name" value="Mlf1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031561640.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="33794" checksum="25D64726C2DA1E60" modified="2020-12-02" version="1">MFGNGFRQFEEDPFFRDHHERMRQTFGMFNGFDRPFVPFMDPFALPRPQESDRDRNRATDNRHDQRGGRDCSRDRMDLAPRDMFGGMFSNIPSMFQNMEQQFERAANDPNSYSYSQSSVMSYSSDGRGEPKYFQAHKATKKAPGGIKETQHAVRDSETGVNRMAIGHHIGDRGRVIERSLNRRTGEEERKQDFINMDEEDVRKFNQEWEQRTKPRTHXLGNRQRERPRHRAIEESSQRRLEHRRDRVEREREREKHHDKDDNTRRVHVRSRPVNRHAPRSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAF2</accession>
    <name>A0A6P8IAF2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-methylacyl-CoA racemase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564161.1">
        <property type="nucleotide sequence ID" value="XM_031708301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAF2"/>
    <dbReference type="FunCoup" id="A0A6P8IAF2">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="GeneID" id="116299623"/>
    <dbReference type="KEGG" id="aten:116299623"/>
    <dbReference type="InParanoid" id="A0A6P8IAF2"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564161.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="41898" checksum="1EB4204AD6ADFE55" modified="2020-12-02" version="1">MDKMAALSGVRVLELAGLAPAPFAGMILADFGATVTRVDKVKSFMTLDRLARGKRSIALDLKSPRGVETFRRLCSKTDVMIEPFRPGVMEQLGLGPKTLMKENPRLIYARLTGFGQDGPMASQAGHDINYIAISGMLSMLGRKDSNLMPPLNLLGDFAGGGLMCVMGILIALLERNNSGQGQVIDSAMIDGAAYIGSFVYKSRDIWPAERGGNLLDTGAHFYDTYQTLDGKFVSVGAIEPKFYKVLLEGLGIREDDLSQQLNFKTWAEKKKNFAKVFATKTRDEWCEIFKGTDACFAPVLSLDEAPLHPHNQRRNTFMKNGDEYEPTPAPKLSRTPGNCTPRRQPSVGQHTIEVLLEAGFGQDEVTDLLKKGVIESQTKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IBH1</accession>
    <name>A0A6P8IBH1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC116298489</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562832.1">
        <property type="nucleotide sequence ID" value="XM_031706972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298489"/>
    <dbReference type="KEGG" id="aten:116298489"/>
    <dbReference type="InParanoid" id="A0A6P8IBH1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22382">
        <property type="entry name" value="KH-I_SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000016">
        <property type="entry name" value="Putative splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 19" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 19" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 19" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="21">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="366"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="370"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="453"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_031562832.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="61397" checksum="3BD085B1A76F82BA" modified="2020-12-02" version="1">MAHMTGANMTPLGRLHPVLASKQNPNPETDQPRIKRAVENRFDAGGTEKKKKKRSRWGKEDTKMIIPGMPTTLPPNLNPDQQKAYVYQLRIEEISRMLRTGDLGIPENPEDRSPSPEPIYNTEGKRLNTRDFRVRKRLEEERHRHIQEAMKLNPDFKPPSDYKPPLIKIQDKVMIPQDENPEVNFIGLLIGPRGNTLKKMEKESNAKIMIRGKGSIKDGKVWQKGPNNNQQNSGEDEELHALVTGPTHESVKKAVNMIQDILKQGIEAPEGQNDLKRMQLRELAALNGTLREDELLSRCRNCGASNHRHWECPEQKNVTNSVICAKCGSAGHLATDCNEKEAITPIPVIQVDKAKMDSEYLSLMAELGEGPPPVPAPLGVPQPDIPPPKVTPPIPPPPIANPVPVPVPAPAPAPAPAPAAPWNSSGPKPLMSTPVPRPVNVRPPGPSNGSGGPPAPWNKPQGLLPPPGPLPGIAPFQPPSVGGPPVQPPPPPPPPNSAGAPVPPWQTTTSVAPWQVPQQQGFXPPPPSFPQFQPAPPPPPPPSDTPWGSQSLMGAPPPPPPPPPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEG9</accession>
    <name>A0A6P8IEG9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ectonucleotide pyrophosphatase/phosphodiesterase family member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565252.1">
        <property type="nucleotide sequence ID" value="XM_031709392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEG9"/>
    <dbReference type="GeneID" id="116300513"/>
    <dbReference type="KEGG" id="aten:116300513"/>
    <dbReference type="InParanoid" id="A0A6P8IEG9"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028199487" evidence="1">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565252.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52814" checksum="3B501C5FB7068E40" modified="2020-12-02" version="1">MYAVFFVALAWLPCCVSSAVDAPPVLLVSLDGLGWTFTGGEQSKTPNLDNIASNGVHAEYMLTVTPTKTWPTHQTYVTGLYPESHGIVSNNFWDPLFKEKFILQYDCSNFDPKFYDAAEPIWLTLQKQGGRSGVHFWPGFYSYKEKPSSFEKPTCFVNCTALNMDSKNLWQHRNKTRSGWPPYIHCFANQSLPYKNRIDKILNWLQEKNPPKFLALYINEPDSSGHSFGINTGEYVEAIKRVDKDVVGYLIQRLQNANLLHKINVIFVSDHSMIETSSSRAIYLSDLVDTSTFTMSEQGVIGHLWPNDPNLEDQIYANLTRVQNPHMKVYKKRDIPSSLHWKNNRRVPPIYIETEVGWVVQPNRPAASSNWTNAGHGWQASKELGAIFYARGPSFKRGYKTKQALQAIDVYPLLCHLLGIKPLPNNGSLENMKEILHSNPSSASVRCVFSTIITYVVPFVMLLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG94</accession>
    <name>A0A6P8IG94_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenosine receptor A2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565749.1">
        <property type="nucleotide sequence ID" value="XM_031709889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG94"/>
    <dbReference type="FunCoup" id="A0A6P8IG94">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="GeneID" id="116300919"/>
    <dbReference type="KEGG" id="aten:116300919"/>
    <dbReference type="InParanoid" id="A0A6P8IG94"/>
    <dbReference type="OrthoDB" id="10353907at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565749.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35475" checksum="A712A27E5B7AC961" modified="2020-12-02" version="1">MKYIDKCSSIAHDISDNFTSSGINSLIFLGFFNSVLAVPTAAANALVIVAILTTSSLRTPSYLLLTSLAFSDLVIGILGQSLLAMMIFSFFSKHAELCCYVLMTCYVILSWTSWSSLFTITAISVDRYLAVRLKMRYKTFVTVTRIRRIIPIIWISSFTAMASIFVLYKDMVTFGVIGGTSQTCCLALILFCYTMSFRALKIHCAQTHPQGNQQPNSATQSNAIDVLKYRKLLKTMIIIVILICVCYLPLIGIFVTVTAPGSYKSKPFRDFMISSGLSTLAGLVTTMTLNSTLSPIIYMTRMRDVRNASAELLRNICSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8II91</accession>
    <name>A0A6P8II91_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116301363</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566263.1">
        <property type="nucleotide sequence ID" value="XM_031710403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8II91"/>
    <dbReference type="GeneID" id="116301363"/>
    <dbReference type="KEGG" id="aten:116301363"/>
    <dbReference type="InParanoid" id="A0A6P8II91"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="7">
        <location>
            <begin position="279"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566263.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="46834" checksum="C2BFDD9030118C1E" modified="2020-12-02" version="1">MAECSSCHTVMPHMENLMVQSNRNLAVQYDTICELVDSDSQPSPVSRRKTPPQPEPSNEQACLPKNYPVQYDTICELVDSDSSPSPVLRRKTPPQSESSNEQAWLPDNSECCSVKGDKTPLPKETSVEGGHILASENVTKTEEKSIAQDESSATKSCKIVVQEVLPIPQVVNFVPHPDNVKNVRKPKDTFVTVEEDHIGNGELHRHVPEVSTEKEDTSDGYNFAKEDNSAKQDQSHYQTLGFPTNIDHCSGENISTDECHKRDRHCCAMPDISRGDLIAITRFRHSYKHFMVYIGDGDVVHRTGGKDEWFSFRKGRIKREKLADIVSDSSMCTLVIENGSWEGHDPLPTDEIIDRAISKIDEKGYNLISKNCEHFARWCRYGQEVSKQVNDLLSQIMLAAVISIPLLAFTCIFYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ81</accession>
    <name>A0A6P8IJ81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Adenosine receptor A3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116301821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566807.1">
        <property type="nucleotide sequence ID" value="XM_031710947.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566808.1">
        <property type="nucleotide sequence ID" value="XM_031710948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJ81"/>
    <dbReference type="GeneID" id="116301821"/>
    <dbReference type="KEGG" id="aten:116301821"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF42">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="37"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031566807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031566808.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40344" checksum="74ABBC87D3ABD2A3" modified="2020-12-02" version="1">MNGSSFRWTRRAKHPSTIQVDVSGLITILLEAATFVGNVLPALAVFFIKKARNRTVTDYFVGALAVNDLFSVAIPLGLGIPTLLMGHWVGTKLGCQLYQVGIFWFQINAMLLVTSMSLDRYLALIKPVYYRRAVIRKIHRVKVLIGILCCTALVISSMPLMKLANNGIRVPFTYCPCIFISKASTFQERIYPSFVLILGSSTLVIVFVCNFVVIKVLKDFKGRFPRGSLSFESSCTGRLDRPSVVVFSKLVFVLGTLFYLTWTPVMVLLLLNQLDQEINELTAVYALSSLTINSLLHPLVYGIFSIQFRQSYWKILRLLVPCLGVHPPCNRHRHHRMSKRCVLRETLRLEKTQELAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK05</accession>
    <name>A0A6P8IK05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Papilin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567251.1">
        <property type="nucleotide sequence ID" value="XM_031711391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IK05"/>
    <dbReference type="GeneID" id="116302169"/>
    <dbReference type="KEGG" id="aten:116302169"/>
    <dbReference type="InParanoid" id="A0A6P8IK05"/>
    <dbReference type="OrthoDB" id="5958863at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027998046" evidence="3">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567251.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22713" checksum="7FC96956E8BBE84C" modified="2020-12-02" version="1">MSKSLNMCASILAIIYILSVVDLTFCDQVHRILDCHKSKYGCCPDGVTDALGWNKEGCSSLLCYDKDKLCKEMKANGDCEAIDKWSEMSELCPKSCGRCKNQGKAASPPACYKSKYGCCYDGVTPAVSDDKRPGVGCPFCKDRYPHACKQFGHRFWCLGKFPRPRFFLSHYCFRQCGFCKNFKEMVLPKEKKDWRKEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILZ6</accession>
    <name>A0A6P8ILZ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coiled-coil domain-containing protein 96-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116302792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568021.1">
        <property type="nucleotide sequence ID" value="XM_031712161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILZ6"/>
    <dbReference type="FunCoup" id="A0A6P8ILZ6">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="GeneID" id="116302792"/>
    <dbReference type="KEGG" id="aten:116302792"/>
    <dbReference type="InParanoid" id="A0A6P8ILZ6"/>
    <dbReference type="OrthoDB" id="10254794at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="6">
        <location>
            <begin position="314"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="180"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="306"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031568021.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="58160" checksum="412D6261645B457A" modified="2020-12-02" version="1">MADEEKAPETAPEQEAVVDEKDGDDEKKDVEEGGEDNAEQPAEDPAESTETAEENKDTEVATEETKEEDKPLELDNTDENLPIPENEGVPEEDVTPAVEVAEHMSREGTPTGDAETDGPAIAMEVPDATITPPPAEEVHEEYEDEEQEPAYVDSYAEQALFDEDEEYYDDSEPEEPMYNRQELLDKYHQALEERSSLQSLNAQLQHKLAEYFKKKKSDERQQEIEKSVTDQEQRYLKYMSNLEELQNEEKHERQSYKLQIEDLKAKCHEREETVEQASAQFTKFKLDIAKDAINSRSGKPIPPKDIEQYEMLENKKEQEVTQVRLENIKLRNRLKKREIQLKAKEELAEGLHLIDFEQLKIENQTYNEKIEERNEELLKLRKKITTTVQVLTHLKEKLQFVQAENADQRTTLRSVEALVAQKRDILTRTKQVRDALRIENVKLRQKCGLLGNESLLRDYELRKDQSDDLSSTIEKLKMTHAELTMNCAGVKKKIDQARQEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMC1</accession>
    <name>A0A6P8IMC1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydroxyacid oxidase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116302391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567533.1">
        <property type="nucleotide sequence ID" value="XM_031711673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMC1"/>
    <dbReference type="GeneID" id="116302391"/>
    <dbReference type="KEGG" id="aten:116302391"/>
    <dbReference type="InParanoid" id="A0A6P8IMC1"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="317"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031567533.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="40897" checksum="8A9537C415B5E667" modified="2020-12-02" version="1">MSTEPVCVQDIEILAKNKLEKSYIIYFESGADEEDTFRENRRAFQRNVSLKIGRINSTQLVRFDILSMKFGQPISMPICIAPTGNQKMAHPDGDLATVRGKGICYLRAFLPRGVVHALGKKLSLALPGSNDTLPWPKSWPPAEAHHTCMVLSYWANTSIKEVADAAPSCLKWCAVKFTENKDFVKDLVRRAENAGYSAIVVTCDSQVSSKRYELQQIAVGAWDDVKWLKSYTKLPVVLKGILTAEDAKMAVEHGADAILVSNHGERFLDGVPATIEALPEIVDAVEGKLEVYLDGGVRLGTDVFKALALGARAVFLGRAVIWGLAYQGEDGVKKVLEFLREEMRTTMILSGCATMKDITRQHVNSSASYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMH7</accession>
    <name>A0A6P8IMH7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WAP four-disulfide core domain protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567775.1">
        <property type="nucleotide sequence ID" value="XM_031711915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302581"/>
    <dbReference type="KEGG" id="aten:116302581"/>
    <dbReference type="InParanoid" id="A0A6P8IMH7"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027955856" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567775.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="10907" checksum="699455B2C15E2001" modified="2020-12-02" version="1">MKTYTALSAILVVLMSMAAIGMTDPVFKKSYVCPNIQCLVSDCNVDSDCRSGMKCCSGCCAVPVKPKPQGKCPNIQCLXXDCTVDXDCNNGMKCCSGCCAQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INQ5</accession>
    <name>A0A6P8INQ5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568135.1">
        <property type="nucleotide sequence ID" value="XM_031712275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INQ5"/>
    <dbReference type="FunCoup" id="A0A6P8INQ5">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="GeneID" id="116302880"/>
    <dbReference type="KEGG" id="aten:116302880"/>
    <dbReference type="InParanoid" id="A0A6P8INQ5"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028505598" description="Post-GPI attachment to proteins factor 3" evidence="8">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031568135.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37635" checksum="C943A172EACA5A2E" modified="2020-12-02" version="1">MRFICGGLEFALAILCCISPVSSSAGDRSYRFLNCVSDCEWISCNIEGYPRDLPWYLRLFSWDCLDECKYNCMHKVTADDVANNRSIKQFYGKWPFVRCLGIQEPASTLFSILNGVAHVAGWQKYVRAVPQDYQMYNVWKTYMLVNVNAWTWSTIFHTRDLNWTEKLDYFCATSLILFSIFTFFVRVVGPDNKLKCGTFASVLLLIYSCHVYYLGFVKFDYSYNMKMNVIIGVINILGWLIWSLRNYHKQRYVWKAAALTSSVFFLIGLEVFDFPPIWWTFDAHSLWHFGTIPLCYFWYSFLIEDAKYQLREEIREKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRV9</accession>
    <name>A0A6P8IRV9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569110.1">
        <property type="nucleotide sequence ID" value="XM_031713250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303668"/>
    <dbReference type="KEGG" id="aten:116303668"/>
    <dbReference type="InParanoid" id="A0A6P8IRV9"/>
    <dbReference type="OrthoDB" id="5963275at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="1">
        <location>
            <begin position="106"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569110.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="31418" checksum="7D2D431DFEBE4490" modified="2020-12-02" version="1">MITAIVFITSLRDLYFSWKKNFSFQILFKMSNAETDSSCSNDSDDSETDYLPEYLLEVEGQQDDLEQQDTSASTRKGLTAVDYCDVFQPYTDEPIASEEWLEEYRSQQEIQQEFERKLQSRSDEMEDVKLWCKCGNCQTEYLQNPNXYQCCLEIEECVESLSSDIVREECLEIPDCITLHPGFEQVCLSKWSLRLAADKYKTKVKSRYSQTGSEERFLRSIAYREFTRLVHGYLGGRRIPLPACAYNKIREKFNDNEYIGFEVEENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISJ7</accession>
    <name>A0A6P8ISJ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Replication stress response regulator SDE2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116303832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569300.1">
        <property type="nucleotide sequence ID" value="XM_031713440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISJ7"/>
    <dbReference type="FunCoup" id="A0A6P8ISJ7">
        <property type="interactions" value="3129"/>
    </dbReference>
    <dbReference type="GeneID" id="116303832"/>
    <dbReference type="KEGG" id="aten:116303832"/>
    <dbReference type="InParanoid" id="A0A6P8ISJ7"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="75"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2/SF3A3 SAP" evidence="10">
        <location>
            <begin position="338"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031569300.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="46499" checksum="BEDBFACA48346D97" modified="2020-12-02" version="1">MSAFLYSPIGNIRVIPASDHWQTQDLLTVLSEGSEAVHPDSVYILHNGRLLPPCSNNTLTISTNDVVRVNYRLPGGKGGFGSMLRAIGAQIEKTTSREACRDLSGRRMRDVNDEKKITEWVAKQADRERELARQKQERLEKRRAGPKHNFDDRTYTMQIQENLEKIDDALKQGLKASTSASGLEVGVKRASTISGDAPKKRKIWMGVDEEELDDSDDDETQTITEKPSCSSSTWTISAPETSTATSATDVCVESNSRGKMSPDQPSTSAAQLSNTAINIDASDTAASNAADHNTAVSTDSASESNSSDENMAEICTTKEGGVVGKTEEEKCENEITEKKKDEENFAKDETMKPFNIDDYNTSEELESLGLEALKEHLKTLGLKCGGTLQERAQRLFSTKGKALEDLDPSLFAKPLKGKSKPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT96</accession>
    <name>A0A6P8IT96_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: short-chain collagen C4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570219.1">
        <property type="nucleotide sequence ID" value="XM_031714359.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304596"/>
    <dbReference type="KEGG" id="aten:116304596"/>
    <dbReference type="InParanoid" id="A0A6P8IT96"/>
    <dbReference type="OrthoDB" id="5988943at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027636003" evidence="2">
        <location>
            <begin position="25"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570219.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32841" checksum="FFDAA526711D01E6" modified="2020-12-02" version="1">MWFKAVVILAVGFVVFCLVQTTEAHQQSARKKVVNPTKTPTTLSDVVNMLRNLEKRIIQIESQRSLLLRGRDDRDGPPGKPGKDGRDGRDGLPGPPGLTGEPRRQGVRGPPGPKSGGVQYVRWGRTICPYNATLLYKGRIGGEHYSHSGGGANYVCLPETPKYGRYKDGHQNAGYMYGTEXEVNTFNPFNTSNLHDHEAPCAVCFVKAKSTKIMIPATYECPAEWRREYHGYLMSDLYNHAHPTHYICVDNDAEAVPGTHEDLNGALLYPVGGVCGSLPCHPYVNGRELTCAMXTCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITP4</accession>
    <name>A0A6P8ITP4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable G-protein coupled receptor 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116304950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570616.1">
        <property type="nucleotide sequence ID" value="XM_031714756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304950"/>
    <dbReference type="KEGG" id="aten:116304950"/>
    <dbReference type="InParanoid" id="A0A6P8ITP4"/>
    <dbReference type="OrthoDB" id="5965754at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031570616.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="62393" checksum="DA1E852D5E875766" modified="2020-12-02" version="1">MNSSSSINESGVLIMYPLQHRSSTEVMAETFIGCLLFVLGLTGNALVCYVIHKKRFTNSSMYFFMLNLAYADLLVCFVSIPLTLLSTRPQPVVVKFGSLPCKIIRFIQYILPPASVAILTATAIDRYFHICVPLKRMITTKATKQLAAICWGSALILTLPIFYLIETQKVMYNGXVYEFCNIEETSTYPTAGMIYLVFRGCLGFAIPLATVSVLYFRIVRTVWQRQSRHQSANRQRANVVKSLLTVVIAFSLSWTPFSIYNKYYLFMKPKREDITRQEIICFWIGLTASVYNPLIYAFYNKKFRNAFVSVVLKKKQTHMSALKPAKVSYRPRSRTLPAVLSLEDRQQSRDKELEGHATLLLNTQSIIRGKKTRHLSLAFDILDKSEPKCRSILFGITNLSYNQSENKQFIPHSFHGSKEHVSSGIINIAEPAVIKNNCSSACVSKKCLKEIVFVPRMVKVEPKAENLSQSKRGLESNLKQHTHRYPTVLKRSQTLRSPTDRAHHVTKNRVSTQKTKFDFQKHGKFSRSNSFHFPSSYNLCNVSNTPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITV4</accession>
    <name>A0A6P8ITV4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein PFB0145c-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570676.1">
        <property type="nucleotide sequence ID" value="XM_031714816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITV4"/>
    <dbReference type="GeneID" id="116305000"/>
    <dbReference type="KEGG" id="aten:116305000"/>
    <dbReference type="InParanoid" id="A0A6P8ITV4"/>
    <dbReference type="OrthoDB" id="10324163at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570676.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="42854" checksum="D54307C008129833" modified="2020-12-02" version="1">MPEKHLIEEIKEMNKKLTVLKAQTTENEKIKLSGYRNRGYIEKLNKDMEDLKREKEEVEKKREYLQKVVKLQGTLEKREGKTIQLKDRIEELEQENEQIEELIKEIADLNQKRDQLENEIIKLKSDIRELKKEIKEMKENHENHQNSMKDAIAKSEENINILRYEMSVKIRQLEDNHTREMDELNNFFENDVDKLKTEHSKMESKLNEYKKHVSYCTEENQHILYIGQLCSNLQTNWYRYVMPKRCHVEHRPYKVKDIIDDIDDRVLLSEEEQNDAKRRWKELQSKIDWKKNKRSIKAIKRIQHQRNQAAHPKVLSEEEAKSAAEELRKQGKLNVKPSFEDVIELINLWKSSISLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUH5</accession>
    <name>A0A6P8IUH5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116304241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569808.1">
        <property type="nucleotide sequence ID" value="XM_031713948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUH5"/>
    <dbReference type="FunCoup" id="A0A6P8IUH5">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="GeneID" id="116304241"/>
    <dbReference type="KEGG" id="aten:116304241"/>
    <dbReference type="InParanoid" id="A0A6P8IUH5"/>
    <dbReference type="OrthoDB" id="2378895at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07096">
        <property type="entry name" value="DUF1358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031569808.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="18937" checksum="6026146D0C6CE088" modified="2020-12-02" version="1">MGNWSHKSKMADEQPGDDSSNKKSVISDSEQESPRVSLTSAALLLTGVTVASMMGGFGVTLGMARKKSPDAFTGRYNEGVKLATRALAYGSLWAIGGVGVIVYGVKTALGVKTTKEFGAKMTEILPSKDGKLVTYFESWRLPRKQGSDDKEVESWFADKPMIQKYNKTQEKDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUY8</accession>
    <name>A0A6P8IUY8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEST proteolytic signal-containing nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in cell cycle regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with UHRF2/NIRF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569968.1">
        <property type="nucleotide sequence ID" value="XM_031714108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUY8"/>
    <dbReference type="GeneID" id="116304381"/>
    <dbReference type="KEGG" id="aten:116304381"/>
    <dbReference type="InParanoid" id="A0A6P8IUY8"/>
    <dbReference type="OrthoDB" id="5981432at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029169">
        <property type="entry name" value="PCNP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523:SF6">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15473">
        <property type="entry name" value="PCNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569968.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13309" checksum="2AE7765F6F542877" modified="2020-12-02" version="1">MNNKPSSFTWMGKRKSGPIETIKPLELSGSKGGGGITIKLNAPAKKKKAEPVIQKKAGSVAAAFGNDESDEEEEIPPEAKMRMRNIGKDTPTSAGPNSFNKGKQGFTHTRKVFEKKLNETKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWE9</accession>
    <name>A0A6P8IWE9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Filamin-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116305872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571711.1">
        <property type="nucleotide sequence ID" value="XM_031715851.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IWE9">
        <property type="interactions" value="1804"/>
    </dbReference>
    <dbReference type="GeneID" id="116305872"/>
    <dbReference type="KEGG" id="aten:116305872"/>
    <dbReference type="InParanoid" id="A0A6P8IWE9"/>
    <dbReference type="OrthoDB" id="5334309at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21311">
        <property type="entry name" value="CH_dFLNA-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21230">
        <property type="entry name" value="CH_FLN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000140">
        <property type="entry name" value="FiLamiN (Actin binding protein) homolog"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000092">
        <property type="entry name" value="Filamin-B isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000007">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000001">
        <property type="entry name" value="Filamin-C isoform b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="28"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="149"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="261"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="358"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="464"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="555"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="648"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="744"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="837"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="933"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="1033"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="1128"/>
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    <sequence length="2923" mass="314421" checksum="60519B5807360AD7" modified="2020-12-02" version="1">MDPNRMDDFEMPDSDPTAADAEWKKIQQNTFTRWCNEHLKCMNLYIYSLETDLCDGLKLIALLQVLSHKKLPRHNKKPVFKSQKIENVSIALKFIEDENIRLVSIDASDIVKGNLKLILGLIWTLILKYQISMPYLDDEDDEDEGRNKMTPKQALLAWVKSKMPESVPMDNFTTHWNNGIAVACLVDAIAPGLIPECEDLDPKDALQNAQQAMKLAQDWLDIPQVLDPADMVNPKVDELSMMTYVSYFPEAKLKPGAPLRPRVHPASKCYAKGPGIEPKGLVVKKPADFTVFTQGAGRGKLGVTVIGPGKVDQEVSVKDNDDHTYSCQYLPQKPGKYDVHVKWNGRHIPKSPFRVEVSSDLDAGKAYAKGPGLAPTGVVAGKYTDFTVFTKGAGEGKVTVKVIDPRGGEDVDVIIEPQENDEYLVEYQPVNAGKHTIKVMFGGQPIQQSPFHVNVSPPKIDPIPSKVKVFGPGVEPTGLKAGSRAPFTVDTRGAGDGDLDVFVEGPLGEEKVDIKNNGDGTYACVYHPSKFGKYVVSVTWSGKQVPKSPFNVKVAPAVDPAKIHAYGPGLEKGVANKPCHFTVETKGAGIDSLGFAVEGPAQAEIKCHDRGDGICDVTYYPMVPGKYAVHVTCGDVDIPKSPFMVPISPPGDASKVYAKGPGLEPEGVCAGSPAEFTVFTKEAGDGDVDVKVMDGAGKKVPVDIVDNKDGTYSVTYYPEKPGMYTVAIHFNDKTIPKSPFKVNIGKTNPARCRAFGPGLEKGFVNQVNQFKIETKGAGEGGLGLTIEGPSEAKIDCKDLGDGSCDVDYIPNEPGDYMINILFADKHIPGSPFKARINYPFDPTKVKVEGPGIEPGIRAGEPADIDIDTRLAGDAKLEVSVVDEQNSPVKCDVEEEEFGLHAVTYFPNKQGNHKVNVKYGSTHVPGSPFKVPISPSSDPSKVKVSGPGVEPSGVEPNKPTYFNIACDGAGKGDVHVSVEPAKRGLKPVEKITVTEVSKDNFKCDYVAPDEGPYNVNVSFAGKPVPNSPFKVNVAKTGDAGKCRAQGDGLETAIIDMLAEFDVDCSQAGTGQLMASVTNPSGAHTDTLVTDNEDGSYSVSYTPFEEGIHDLSVKFAGDHIPGSPFKVDVLPPTDXSKCKAYGPGLERAEINRPAEFTVETKGAGAGGLSLAIEGPSEAKLTCTDNGDGTCSVSYVPVEEGDYDIHIKFADEHIPGSPFTAKAGLPVDPSKVKVHGPGVDTDNPLYSKAPQKLIVDTTEAGIAPLDVAIETPNRKTIKPDSVVEEKPGVYAVTYLPADEGRYNVNVKYASTHVPKSPFRVRAGPPFDASKVKVSGRGVDEEPFTEEPVEFVCDCSEAGDAPLSVVVSPPTGRDITPEIKDNGDGTHTVKYVPDKPGRYNIDVKYGNRRVPKSPFKPTIKPAGDASKVKVEGLGPDDVAIVRQDNEFVIDAREAGKGTPEVSCVGPNRKKVPVEVVSNKDGTYTCFYEPQDEGRHAMDIKFADKPVPGSPFHVKAKEGVDVSKIKCAPKNPIDEPAVNQELVYAVDARPVEAFPSHNPIKGTLEGPNGKKEPIQAKDNGDGTYDIGCVPKEPGPHKLDVKYEGQPIPGSPFKFNAIEGGPGSVKAFGKGLERGLTKEPCEFTVVTRDAGPGGLSLAIEGPSKADIKCEDNGDGSCNVSYVPEEPGEYNINVKFADKHIPGSPFAAQIYNNWDDLAAAKPRPTVGKVCDVGLDIPDVADISKLKGTLKRPSSTRDEPLELRVNDDGSLGVTFVPYEPGEHLISIKKDNRHVQNSPFSVMVQAQRLGDVFPVGHTADVVIPGLDNYGDLSKLQATLRRPHSKVEERVKLIRNPDGTVSVSFVPREPGEHFLSVKRDNTPIRGSPFSILVEAEEPIEAVGCPVDYCFDIKDDVNLPEEFDKLQATIKRPSSDKEEPIGLKINSDLSLSASFIPRETGIHLIHIRKRGRDVMGSPFSVNVTAPEAVSQVGRPYGLGLDFDDVNLPEDFPRLSATLKRPSSKEEEELRLLLNGDNTLGVAFTPREVGEHFIHVRKDGHELKNSPISVMVVGKEEKVEEVHPMKKTCDLSLDIPGVRLPEDFKLLKATLRRPNSDKDEPLTLKLNEKDNTLGVSFVPVEPGEHKIHITKSGKEVPGSPFSVMVEAAEPVNAVGKPCDCCLPGQFDEDDLKRLTATLKRPSKKTEEPLKLKLNSDKTLSAVFVPQETGEHVISVKKFGKHVEGSPFVVMVVAPESSNAIGKPCGVGLEIPGLKLPQDFNLLTSSLRRPGKTYEEPLKLVLNSDNTLSVSFVPQETGEHFVTVKKEGRHVTGSPFSVMVSGPGPADASKVKVYGDGLKKGVVNTPARFTVNTRDAGYGGLGLSIEGPSKAEINCVDNEDGTCSVDYLPKEAGKYTINVKFADEHVTGSPFKAMIRRPGEEEIVCEDVDGLESEPTQRVSQVFEDLVSFGGAAPQPQDFVFDLKGYKIEDLQTTVVDPTGEELPSEIVESKDNSYTIRFMPKESGEHIINVMYRGRHIPGSPFKLFVEAPAWGGAAKCIAAGPGLERGVVNELGEFTVWTRDAGPGGLAIAVEGPAKAEITCQDNGDGSCNINYLPTAPGEYTIHIRFADEDIPGSPFKVFVTSEVEDRFRNLNIKDLAETGLKVGQPASFSVQTNAPVGSVTATVIAPSGNESKAVVSSLGNGNYAIRFVPKEFGDHLVNVKFDDTHIPGSPFKIRVGGGGSYPEKVKAYGPGLSSGKAGEPAEFTVNALEAGSGALALSVDGPAKVKMNCTENQDGTYQVTYYPVVAGEYTISIKFAGQHIPDSPYNVTVFSSSGKGPTPSDGDASKCTSRGTGLHRAVLGQPNSFTVNASNAGRGSLMVGVEGPAIPAKEINVKHTGSNVYAVNYALEEPGTYILKVLWGEKHIPGSPFHVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWQ4</accession>
    <name>A0A6P8IWQ4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116305965</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031571836.1">
        <property type="nucleotide sequence ID" value="XM_031715976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWQ4"/>
    <dbReference type="FunCoup" id="A0A6P8IWQ4">
        <property type="interactions" value="1579"/>
    </dbReference>
    <dbReference type="GeneID" id="116305965"/>
    <dbReference type="KEGG" id="aten:116305965"/>
    <dbReference type="InParanoid" id="A0A6P8IWQ4"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01578">
        <property type="entry name" value="AcnA_Mitochon_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="67"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="582"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="529"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031571836.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="84543" checksum="1EA9D89887D764C8" modified="2020-12-02" version="1">MQRFFSRQVLTSLRTVHSVRYFSASSALWQKVSMSKFESNCYIPYERLDENLKVVKERLNKPLTLAEKIVYSHLDNPKEQDIVHGESYLKLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHFIEAKVGGAEDLKVAKDINQEVYDFLASASAKYGVGFWKPGSGIIHQIVLENYAFPGVMLIGTDSHTPNGGGLGGVCVGVGGADAVDVMANMPWELKCPKVIGVKLTGELKGWTSPKDVILKVAGILTVKGGTGAIVEYFGPGVDSISCTGMGTICNMGAEIGATTSVFPYNHRMETYLKATGRDQVASLANQYKHLLKADEGADYDQVIEINLSELEPHVNGPFTPDLAHPISKLGAVAKEKGWPMDIQVGLIGSCTNSSYEDMTRAASIAKKAMENGLKAKSLFTVTPGSEQIRATIERDSIANTLQEFGGTVLASACGPCIGLWNRQDIKKGEKNTIVTSYNRNFTGRNDANPETHAFIASPEIVTALSIAGSLDFNPETDTLTGKDGKQFKLDSPFGDELPTKGFDPGEDTYQGPPEDGSSLQVNVSPSSNRLQLLTAFDTWDGNDLEDMTILIKIKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGAINIENDKANQIKNQLTGEYGTVPDTARHYKASGVKWCAIGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLMFSDPSDYDKIQPDDKISLVGLKNLAPGKPVECHIKHKNGSVTKISLNHTMNEPQIGWFKAGSALNKMAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWV1</accession>
    <name>A0A6P8IWV1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">LOC116305730</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="32">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031571557.1">
        <property type="nucleotide sequence ID" value="XM_031715697.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IWV1">
        <property type="interactions" value="2555"/>
    </dbReference>
    <dbReference type="GeneID" id="116305730"/>
    <dbReference type="KEGG" id="aten:116305730"/>
    <dbReference type="InParanoid" id="A0A6P8IWV1"/>
    <dbReference type="OrthoDB" id="6019793at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01242">
        <property type="entry name" value="PH_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22250">
        <property type="entry name" value="ROCK_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05596">
        <property type="entry name" value="STKc_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000047">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000308">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.730:FF:000001">
        <property type="entry name" value="rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000072">
        <property type="entry name" value="Rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015008">
        <property type="entry name" value="ROCK_Rho-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF73">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08912">
        <property type="entry name" value="Rho_Binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51859">
        <property type="entry name" value="RHO_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19 22 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="73"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="29">
        <location>
            <begin position="338"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="RhoBD" evidence="30">
        <location>
            <begin position="971"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="26">
        <location>
            <begin position="1140"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="28">
        <location>
            <begin position="1254"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1038"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1346"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="423"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="633"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1355"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1372"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_031571557.1"/>
        </source>
    </evidence>
    <sequence length="1397" mass="161725" checksum="7BD009A3E2D865E7" modified="2020-12-02" version="1">MELERKRMETLEKNVRNPRSALYIDGLLDGIEALVNDCNFPQIRRNKNVENFLQRYEGPTKTIQDNRLRSSDFNILKVIGRGAFGEVQLVRLKHSDKVYAMKLLSKFEMIKRSDSAFFWEEREIMAHSNSPWIVKLHYAFQDEKYLYMVMDYMAGGDLVNLMSNYEIPEKWAKFYCAEVVLALDAIHSMGFIHRDVKPDNMLLDQEGHLKLADFGTCMRMXKDGMVRSDTAVGTPDYISPEVLKSQGGEGHYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYGKIMDHKNSLQFPEDIEMSAQAKSLIKAFLTDRAQRLGMTGIHEIKAHKFFNNNDWEWDSIREAIPPVVPELRGDDDTSNFDDIPDPDAGEEFFPVPKAFAGNHLPFIGFTYSKEKRWATRSDMPSDVLVSGDGSNFVNKTSNETIELVNQKNXKLEKELNNAMQEKAEIELNFRNASSKLEKVLREFEKEAEARRITEAKNRDMERDAAQFKYDLREAQRKVEYETDNKRKLENKVQELQSRLDAELSQRDKISQSSQNVQSRITFLEKQLAEHQAQMKTEAEAYAKTKKLHGDLQKSYAVLERSYGDLQEKNRVISDQKLSLERELIKVQASLEAEVNMRVQANSAKAAIESQFQSLRDEHDQLKSRTSSDARVQQKLQQDLINLEKEKANTEYVLKSLQQKFEQATLDYKTQISSFMTEKKRLSLTLEEQHVQERVEQTKTMERLKLEQEARAKAEAAAAEAERARTVMAADYKDVSQKLQRVTEELNALQEKKGNDNAKLNAESQKRAQLEGELESKTKELAAIKSTEKQLQKRMDDILEEKHQLEEGYSKLKSASAMDDLQMKELQDQLEAEQYFSTLYKTQVKELREEMDEKNKQIQDIQSEVKHLREERESLSAQLELTLTKADSEQLARSIAEEQYSDLEKEKTMIELEVKELIARHKSDMSDKAAQITQLEELNQQLTSSLDQKVHEKEELNSQINQIKAELEKANDSNKDIETATEQIKKQLRIEQTLKIQAVNKLAEIMNRKDWSKDSQKRNKVSSADLRKKEKECKKLHQELAAEREKYAQMTSKYQTQSAEVTVNLQMEIEQRQKMQMELESKDLMIEQLTNKLKNAAANISVNEEKPSISASMNKEGWISVPNKQNIKKYGWRNQYLVVSSRKLFFYNSDNDHKNGSTPVMILDIGKLFHVRSVTQGDVIRADAKDIPRIFQILYANEAESINPVEKEKEEQQSPEEKMATINYMRHQFIPMHFHMPTNCESCSKPLWHMFKPPPALECRRCHVKCHKDHVDREEACIQPCNVNADMISAKDLLVLAASPDEQKEWVLYLSKKIVKXPPKSKSSVRHPSDEQNMRRHISERSMSTQQQRVQPSQPQRSTSMSSQARHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX88</accession>
    <name>A0A6P8IX88_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116305873</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571712.1">
        <property type="nucleotide sequence ID" value="XM_031715852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IX88"/>
    <dbReference type="GeneID" id="116305873"/>
    <dbReference type="KEGG" id="aten:116305873"/>
    <dbReference type="InParanoid" id="A0A6P8IX88"/>
    <dbReference type="OrthoDB" id="5954192at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010797">
        <property type="entry name" value="Pex26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16262">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16262:SF2">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07163">
        <property type="entry name" value="Pex26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571712.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34396" checksum="2F333B620098D661" modified="2020-12-02" version="1">MDVAMQIYSAKRLLVLRDYKTSLEKCEEGLEALQNEEEVERISVLDEEDGVEKARIAFGVLALQGLTLDGRENEMDAFAGKWFGCSRNFPSEILQICACHHLQMQESQLALDLLEEWLSEERNHNSSGLNKVAELYVRHILLPLKEIEKAETFLEEFKAISSENKKELIMYISKKKEELSQPVTDEYEINTDVSDQSSCSSSSDEVAATKKVLSKGPILGLFLKVFKFFKTIKQMVINNASMKTGLLSCARLVVLAFFLYIIFLRTYLPGDVFNGRGSGSVLLWNAVKQVWSALFAPYHMIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXH8</accession>
    <name>A0A6P8IXH8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116305936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116305936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571797.1">
        <property type="nucleotide sequence ID" value="XM_031715937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305936"/>
    <dbReference type="KEGG" id="aten:116305936"/>
    <dbReference type="InParanoid" id="A0A6P8IXH8"/>
    <dbReference type="OrthoDB" id="5987088at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057507">
        <property type="entry name" value="Sha_B-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23328">
        <property type="entry name" value="Sha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027977538" evidence="3">
        <location>
            <begin position="25"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Shavenoid isoform B-like N-terminal" evidence="4">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571797.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="77054" checksum="E78449FD7BB0B4DF" modified="2020-12-02" version="1">MMSWLWSIWMICLFCFSLSTSAEAANQIIIRRGYLLSSYTIFDFFNYTASICGKKKDVHIWCNAKNAEQPSRHSLNPPWPMCSCQCQHNFETFLSKEEKCVNTSYLKTHEDFGSGTYKFNPQADFTKASSIQLITPSTTRVCNSCKVHEAMYFKKNGWKNTGHGIKIRINVGTCTLFWNSSSKELVGKLLKIQLKNCIYHELNKLFFLKSKGSYVIDVPIPPPSPPPSSTVVATISSSMDSTETPTFTSSSTPTVITTPTPASTVAATISSSMDPTETPSFTSSSTSTVTPTPASTVAATISSSMDPTETPSFTSSSTSTVTPTPALKTSTHQVPEFVTTPQVSPTKTFIVSSHVCSSGDICPSSSSVAVFLPTTAIQSPTNRTLGYQNSLGSSTWAIIAAVVACILVGGIIALFVVLRRRRRDNRRARFSKDPAKVPTPDTDNPMYGHNRGDVISLSNRQSGHTQKDEDEEYDYATVDGVRSDHQKPSTPIYQSLIKDNVGSSVYDPLNKVATTPMXYSYNHLQHPQYNPARSKSDPLYNTLEIPDDDEYQEPETQIIDNPTGVSEPVYNVLEGPDANSAPHDDDPVYNVLKDPNTNQDNDPVYNVLEGPDDDYDNAPIDDDQNIPASGQDNVTYSSTIDLNIPQSPSSPDYDVLEDPEGALPDSTYQPLSIRVQDDVYQTLDRASQSIYQTLEPNDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXS2</accession>
    <name>A0A6P8IXS2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Centrosomal protein of 41 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116306083</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CEP41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571979.1">
        <property type="nucleotide sequence ID" value="XM_031716119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXS2"/>
    <dbReference type="FunCoup" id="A0A6P8IXS2">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="GeneID" id="116306083"/>
    <dbReference type="KEGG" id="aten:116306083"/>
    <dbReference type="InParanoid" id="A0A6P8IXS2"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051889">
        <property type="entry name" value="CEP41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="172"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031571979.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40995" checksum="8A526E9E3E409668" modified="2020-12-02" version="1">MSSTSRAKKINVLDKKIPENPKYKHVKATVDTGSSVTKYMERIEDMRKNYKFRKDEIFKRMKVSTFAQLVLQVAQVIQVEEDRENLISAAGSEMSDTSTLIPDEKEMEENVPPLILGDENERPNTSGTETSRSTLHGLIHGVGEIDMKDKEKQDNNPQTPQVQTSTYAPDIESMPYLLLDIREKDAFDKCHIIGALNYPASMLSRSYNYFTKEILMFKNKVGKIIILYDEDERLTGPSATTFVQREVDNLFVLSGGLKVLAKKFGDCMITGKLPASCIPTPPPSRKGSGKQRLPQPSTPGTQQHYNYFTYEQLEKIQEKLDDELLSQDSKSRLSSRVSSRSAVSSASSRLSTASSASSNKKSVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1A9</accession>
    <name>A0A6P8J1A9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Substance-P receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116306035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571923.1">
        <property type="nucleotide sequence ID" value="XM_031716063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1A9"/>
    <dbReference type="GeneID" id="116306035"/>
    <dbReference type="KEGG" id="aten:116306035"/>
    <dbReference type="InParanoid" id="A0A6P8J1A9"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571923.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28210" checksum="1B0F6C489FF99A80" modified="2020-12-02" version="1">MSTGIALCKVVNFVEKVSITVSFLHLGALAIDRFLAVFYPCKSMVSIRSSKITVAIIWGFSICYWGPILYFGGLGVKDGQTVCAVREFTPYWEYWYVLFLVLLFATLVLILVLYLLVAFKLWLRKLPGHQMSSILKGVDRSKRRMARMISIIVAAFYICFLPYWIGWISCSYLVTQLKTTCNPTYEFISILLLHSNCSINPIICLLFNLQYRLELKISLQDPLGLRVKAMRISYRRRKTSEPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1K4</accession>
    <name>A0A6P8J1K4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573457.1">
        <property type="nucleotide sequence ID" value="XM_031717597.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J1K4">
        <property type="interactions" value="1445"/>
    </dbReference>
    <dbReference type="GeneID" id="116307369"/>
    <dbReference type="KEGG" id="aten:116307369"/>
    <dbReference type="InParanoid" id="A0A6P8J1K4"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="485"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573457.1"/>
        </source>
    </evidence>
    <sequence length="823" mass="91167" checksum="50F2B50933F69177" modified="2020-12-02" version="1">MKPGHHDVASRHLGSTHERNSGTIMFRVGKNTQLLRLKCVSSTLPCSKTSFQICTSYTKPGRPPLSAKRFLSTNTPKKNNSLGRKIAGTIALITGGGLVGGTVLYSYNEDFRKFVDQSLPIIETFNLALGPALKSSVENNNNNGKELKPKYTEIKPFIDVKQKENEKPKEPGGVKPNAKKNVASLSSLDQATVSSVDLDIASVVEDEVKQVPKEPPAPTPKTEQKSAKESVSDKLKDSVASFVSAVDQPTVSAVDQTIAKGSKPKPPPVIKEVDSTTEDIKLQAKEGSVHQDTSLTEKELNDMVDQTAMEIMVEEALLVLKNSAQEAVNAQQKATDSVLSHIKLLKNALEQEDAGSMKELSKVVLDAQKDADTAISEGKASQVKVNQEIAKLYAVIKEAEASGAKDAGLKASEQAARITYEVTNIASELQKAESEDTLLQQHQKFLDESKHMLKKEIEEVLPGVLKETTGTGKKADEAKSNAVLLAYACKRIEHLKQELASHREEERKRLEQVLSVQRKEDAKLAEIKIKQELEKLRAEFHISQKKRESELDLEHETNLRQQLRRQAAAYSDHLTEVLRVQSQELQQRYDQELTKKQNEEKEEYSNKLKAALSRLRGIEAAMDSRADIEKSNKTAQDLFVACQSLQSAIDSGVKALKPLFPEVTAIQMAAPNDTAVSRVLAAVPEEALERGIYNEKNLASRFPGVLKSCRRVAMVGEETKGPWTYFLSYIQXFFIIDKFDPRKDGELIDVENMDTFGLLARAEYYVSKGDLEVAARLVNQLKGEPRKVANDWLKEVRLLLETKQVARFLTSYAASLXMGGLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1W9</accession>
    <name>A0A6P8J1W9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573524.1">
        <property type="nucleotide sequence ID" value="XM_031717664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1W9"/>
    <dbReference type="FunCoup" id="A0A6P8J1W9">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="GeneID" id="116307414"/>
    <dbReference type="KEGG" id="aten:116307414"/>
    <dbReference type="InParanoid" id="A0A6P8J1W9"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17048">
        <property type="entry name" value="Ubl_UBL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047977">
        <property type="entry name" value="UBL3_Ubl_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573524.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14142" checksum="94E8F8D70D580EBC" modified="2020-12-02" version="1">MTTASQRQCKVIPEDKICLRLILVTGKTHEFLFSPSDTAYFVAQHVFENWPADWKEETVSSHNILKLIYQGRFLHGNVSLGALHLPLGKRTVMHLVARENLPEPAAQGPRKREKSGERSCCCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1Y3</accession>
    <name>A0A6P8J1Y3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116307484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116307484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573612.1">
        <property type="nucleotide sequence ID" value="XM_031717752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1Y3"/>
    <dbReference type="GeneID" id="116307484"/>
    <dbReference type="KEGG" id="aten:116307484"/>
    <dbReference type="InParanoid" id="A0A6P8J1Y3"/>
    <dbReference type="OrthoDB" id="771227at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031573612.1"/>
        </source>
    </evidence>
    <sequence length="909" mass="102377" checksum="BE8AE3200BD0F2C3" modified="2020-12-02" version="1">MYRFSSYLRIPRTRLFSPRVSSRIAHIRGRSLRFSTQSEANISKSSAEEAPKSWRENPNLKYWVLGVSAITGIIYRYVYKEKEKKKLIVKNFPSLPNHKVQARNADLHELEQLHRNKSSSVSFVHLGGHTGSGKTLLAREFAEKLFKDNEKRFCFLPFNLFVGTVSAASLETLLFDVKRFAVAIGCKTKDWLDRVGEGRTFTGLSSDEQLHVIVEAVKEKLRANPHWILILDGLKDEKILGKLFDEEDKSSWGKGTVLITGCNQPNLYYVNSYSVDKGMDRFEASELLQDLSGLPEEKLEGVHTVLNKLSYSPLGIGCAGNYIKSRLNKDPEYTMKQFSDELNSGLLKFAESNKSRDLPKEHKESAYVTASLLVKEYIEKFPHFLHTFDLIGTCSVDWPIPVTLVSLHLRSPEFHLAPVPRSQSVLPSLPEDRNADQQQPKPEEDVQDSFLSIKRIASNLESFTETLKANYDAIKDAFYPPPVDTSPPTDGVFDLMKSCSLVTVERVDPGGVETLRVSPIVHELMSQLFLSTTAPLLETNCLTQAEEKYRNSSWFRRFWQFDPQRSLQEFRNSLGESVETQKFLKDTDNTVEDEMAIDNKRSSVPDLSFLLKDEESIPDLPSYRSIQPQVAVKHYQNHISLVLNTIKGVSSVCSQDVQTRTLARLLKPHLDHILTSNISKSLEPKSRAHALSAVAAINSALGNLQASIPSLERAVEIEEEKFGESSLEVAVTLTRLAEVYSSLENPTKARELLERAIGIYDLQRKKSGEYKKPLEFARTMEALGAVYGTLGFKLRSKEFIERSLSYMQASAPISDDEIERRRFACEVASTLTDLGHAYLSTGDAVSGRKMLELAVTGLKNMYGEEHPEVVRALTVLGTAYTMQGNWQEGKKMRREAGKLQAKIDGLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3L5</accession>
    <name>A0A6P8J3L5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116306291 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572175.1">
        <property type="nucleotide sequence ID" value="XM_031716315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3L5"/>
    <dbReference type="GeneID" id="116306291"/>
    <dbReference type="KEGG" id="aten:116306291"/>
    <dbReference type="InParanoid" id="A0A6P8J3L5"/>
    <dbReference type="OrthoDB" id="5971274at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="332"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572175.1"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119458" checksum="F15F07413C0DEA7E" modified="2020-12-02" version="1">MNTTRGLKHIETITEADEEEEEYQNRHISKERINSHLGSGLEKWQKAMEEQVGNDEQDCISTRSRTQTTEAPVIFDPDGMRIVRGTTCISSEFRQRSYTDPTDLLWVFRRRWNIMLDENDNEDNEYDKTSNKRDEWSNKDGKQQLDMYKMGCDDGKEGRLQKSSNESLSSREGKHSDSKGLSASSDSDPRDSMEDSKAQTDLPSVARKISAPAFRMGRRSSQVQMQMHAHRRSSVSALPRRMARRGSEVPALTSLARRRNTLTPSYPVGLKRRGSRGFSNAEFHLNNIQTKAKHEMLANLVLPAFAEPSFRGGRERRITYGCPTAKSKKDEKRFQVTNEILETEKKYLACLNTLKNTFEDPMREGNFLTPKEIDIIFPNELGLIRESHTHFMKDLEERIENWKQYGIVGDIFTKLSSSYHVDVLKIYSDYVNNFPRAMAIINKSSRSSQKFKRFLQACSTDPDCEGLDLGAYLLTPIQRLPRYVLLLRQLSKSTEASHPDSFHLENALEKMKNMINILNDSIQSSCKIVNVSISRKSTKRKSLRKRPGIKDLKITKEDNDSSRSSQDKTTADGNPRSLKSPTTTDSPLNSPISPPDVSSTTQESRLSPSPESQHSVLTRVKSGDKKSRPVSTGDLDRFYDADHSKEFNAIIEEGEGNDKAAGQSKFRIAAESVKRSWQRRSKKWRRSFEGKCGSTSTLPDLGRDLGSPRELDNSSERFPYSESTSPTISPSVSLENTKISDDTQRIVACNPLVSGENSEGCYTSPLPSPVFSTDNISGQETDMATSDVTTIKETEELTLPTFPDDGSPYMTHRNIRRKHAIQETRPCSVALPLRESSTEETGTDAADKSQSDNNLLTSSKNKTRGSECDAPENIWVPRQRPGLQKRSSSDGVRQQYLRRKVSNTSSDHNLGSTSTSRGSLDKSKDSLIDSGVSGTPDYSPANTLSKNMTKTLPINDKTLQNMEKFKQLSLEERLGFEEIIASGFGENQRKLKSDEELDKLREGAKSKKKFKDVVKQIFSKKKRKSVSSLEDALQAKKSSKILTRSRSLNRKDSKDISSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J579</accession>
    <name>A0A6P8J579_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116308519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116308519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574822.1">
        <property type="nucleotide sequence ID" value="XM_031718962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J579"/>
    <dbReference type="GeneID" id="116308519"/>
    <dbReference type="KEGG" id="aten:116308519"/>
    <dbReference type="InParanoid" id="A0A6P8J579"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000481">
        <property type="entry name" value="Asator, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="710"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="800"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574822.1"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120497" checksum="09B54CBE28FAD176" modified="2020-12-02" version="1">MADNLLKAGDVVRQRWKITKKIGGGGFGEIYKGLDMVTHENVAMKVESVHQSKQVLKMEVAVLKKLQGTEHVCKFVSCGRNESFNYLVMSLQGVNLAELRRSQPKGVFSLSTSLRLGVQILKSIKFIHEAGFLHRDIKPSNFAMGTSPDTCHICYMLDFGLARQYTKANGEVRPPRSSAGFRGTVRYAAINAHDNKEMGRQDDLWSFLYVMVEFSVGHLPWRKIKDKEQVGRMKHNYNVNNLLKPLPSEFKQFQEHISKLTYEDKPDYKLLMGLMEQVIKRKGIKESDPYDWEKVHSHEVSQTTTNTSTPLIGQMQSTPHENKDHLEIHGSDHPIPTADIIEELTDHLIENKGNNPRNIGGDVKGGKKDKGAIQKIKEVLDAVGSNGKLINGHCNLVTTMNEGKLKNGEDKALETPAIISAIVRDVQKAQVAKVDTNQDTRTPKDMHEQNEAGENHKEWFDVVPETVDGAVENVQNNIESSPGEGTQKTVILTPDSTPVKIVDTPSESPAWPGIVITEPEPNEQEKNKEDGGDIAHKPWLEDNAEDQPVVMPTPLLHATYHQGDLPALNRHREIKVNYINHHAHLSPDIDDILGPADEDYVLRTWRQTASMEHLNVEDQKEGSREPRMKNSVSAPDLQVNLDLYRVPSVLEQMQYERPALTSKTVSTYITQEVAEYKLDSINFASDKEVSSTESHRGIHVDVSRNIVTTNPVTTSNDYETRDSDDKGVAAGSGLTTGDLGYQETSNISNSEDTKSENYEGREESAPDEDFPEPADIELDTVDVNEQTNNVKIIEFDHTFSESSSFDKESEKIERSENNTPQNDGVNLPVNDQLQETLNLEQRPLNDIRQKHSSNEVEENYKEPYSEPSVSDGNENNLQIAVEDKLNQHESEDDAEDKNYNMPSINELEDNNGTLSMGKVNESQNEDYDVEEQCHIPTLNELGSNDIVAEASTSNFGFGQLVEDSEPVPAPREGRSGSIDEMCRIPTLTELAVEDYGVVMEACTSNDILEGRRYSEDDIYTNTRHGTETASKPLHPKPPPGRSGNGCVQARLRRYKQKKHNGFIPHLVALSDKPVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5J0</accession>
    <name>A0A6P8J5J0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031573188.1">
        <property type="nucleotide sequence ID" value="XM_031717328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5J0"/>
    <dbReference type="GeneID" id="116307179"/>
    <dbReference type="KEGG" id="aten:116307179"/>
    <dbReference type="InParanoid" id="A0A6P8J5J0"/>
    <dbReference type="OrthoDB" id="5957954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000139">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF901">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028520488" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573188.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35340" checksum="98EF68F303F8C9EB" modified="2020-12-02" version="1">MGLQTVAFLAALVVATLTLASGKPPFPKPSSEVFDDLLARKIQENAKRGGNVHGHIVAVNDASRLIKSQDSDDDIPLTEDIEEANEEANVDLFEGDILLPDDEDKEEEDDMSQSEGSKRNIIKNKNRLWSTVVPYYVSPKLGYMNAKIKQAVNELQTKTCVRFKKVSSGYNGDHIRLVKGRGCSSSVGRQGGGQKLNLGAGCNYAGVVIHEIMHSLGVWHEQSRQDRDKYVEVLWNNIKRGRSKNFRKYSHGMLDTLNLPYDTSSIMHYDRFLFSIDPGRKPTIIARGMPWKKLGGQLRGTLTANDVSEINSLFKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9S2</accession>
    <name>A0A6P8J9S2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Thrombospondin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC116308249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031574493.1">
        <property type="nucleotide sequence ID" value="XM_031718633.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574494.1">
        <property type="nucleotide sequence ID" value="XM_031718634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J9S2"/>
    <dbReference type="GeneID" id="116308249"/>
    <dbReference type="KEGG" id="aten:116308249"/>
    <dbReference type="OrthoDB" id="5984412at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017878">
        <property type="entry name" value="TB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51364">
        <property type="entry name" value="TB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653300" evidence="8">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="TB" evidence="9">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031574494.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="33892" checksum="7A61FD0557F2B8D6" modified="2020-12-02" version="1">MKTAVLIAIITLTVTTAFLQVTARRKGVCYTKYTKEAGCRKRGEFARKKVNFDDCCKNKGKGWSANRRGRKTCRPCVEVKIETGYWSSWGKWTGCSKTCGTGQRQRKRQCISKQNTTCSGREMQARKCQRTPCPVNGGWTSWSTWGPCSVTCGKGHQNQIRSCSNPKPQHGGKECQGSPEKWKACLLQEHCPIDGGWGEWSAWGACSKTCGLGRKTRSHKCDSPKPKYGGKPCNESEALGVDYCREERCGKTSVGCDESYEDCSSGSGSGWKISSGSGSSGLGSGSGEQSGSGAVASGEGLSGDSKPLDDEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JBG8</accession>
    <name>A0A6P8JBG8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Melanocyte-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116308700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575038.1">
        <property type="nucleotide sequence ID" value="XM_031719178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JBG8"/>
    <dbReference type="FunCoup" id="A0A6P8JBG8">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="GeneID" id="116308700"/>
    <dbReference type="KEGG" id="aten:116308700"/>
    <dbReference type="InParanoid" id="A0A6P8JBG8"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031575038.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39597" checksum="5F91D66B134CBDE9" modified="2020-12-02" version="1">MANNFSCGKLTDWVNHSNTYLERSSPILLVVFAMLIPPAAILNALVLVVIWRRRILQTTSNLFLRNLALSDLAVAIWVLPLLMTCSAVNISHISERIICNVANVASVSSHIFGSVSFLTMTAATVDRYLALYLHLRYTAVVTRKRVIYSCIGLWLISIVTSIILPVSFALYKTVVVLFFSGSMMTIMFCYYKMYRILKYHHAQIQIQMAGQPVAALPNMNKYKSSVMNLVYIFLLYIVLYVPYIFGCMMPMENMKQKHEAMITMMVGLVLIFLNSTLNPLLYCWRQMEIRNAIKDTVGWRPAMCMTSESIRSLRTYPPITSKASSNTLSSPSTINNINNIIQDTNITHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JBH8</accession>
    <name>A0A6P8JBH8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM221A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574050.1">
        <property type="nucleotide sequence ID" value="XM_031718190.1"/>
    </dbReference>
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        <property type="interactions" value="26"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
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        <property type="entry name" value="PROTEIN FAM221A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031574050.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31425" checksum="7039FCFEEF67B36B" modified="2020-12-02" version="1">MEQNRIHLKLDASAAASVDAYWEYKKIVGEDDGGRLFTPEEYENYKKKILPQRLKNRLFVSWTNPDGLDCKLVGPETPCFCTHSLTLDVASLVLFQLVGYSYLLNQGLYPQTIKHFHFCNLQMIIETKEERQARGHPVGEDVPYAAMGGITGFSSLMEGYMRLDDSGIGPPPKEFLEQPIGPHDHAFLKAHANMAELSLEDRKDGAMAGMTQEERDMAWFEKRYQERRKAEREWSRVKHIPPKKLTASGGSPSTSRSPGASPRGSASRTREPGAQRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCQ8</accession>
    <name>A0A6P8JCQ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 99-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575383.1">
        <property type="nucleotide sequence ID" value="XM_031719523.1"/>
    </dbReference>
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        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="GeneID" id="116308995"/>
    <dbReference type="KEGG" id="aten:116308995"/>
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    <dbReference type="OrthoDB" id="10262255at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039341">
        <property type="entry name" value="CFAP99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34649">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34649:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575383.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="77399" checksum="D6627A59145C11A9" modified="2020-12-02" version="1">MKYKELIKVCVELLDGFNPNIHGVQEHVDSHLSSIKDIEENEDVFITEVFSGCVQHISILKVVVDAFYVDVGKTCLLVDKNLYLVLTYLALYRLDELGLSHFKKFIASQDSNKMHRFLAFLFNEQNIKTWMKAEWCKQYEHSYVKANLLSPLLRWLPDLKEIVKKLEDKKANRQKPKPSKPATEIKPFNLTKPQPRSVPIPDKIPKLQKSREVPQTTYRQPFEEEVLSKVHEENRKKAEEELMKSSAKQFSCASAEKSAKTRERMQKIMKEEEAKLQFNKSKVSEVPSTMVGNVPIRLNAAAIMREGVLFDKKEEEELQRLAEYEKGGKDPSEFLKWQESMRKKDMEENLAEIERRRLEGKLSYEEAILARQTLIKENQERVQQIKLETQEMMNEYLKKKFEEEKEMRNLVESTMEGHQNTKEARKKLQEFKQKIVQEVAKESQEMMRKALEAAEEEMRQKVALIAKIRAIESVPVIRFKYVDLTETSGAGLLSEMSIAELRERLSLLKMAEKEEMEEKSDKILKAKVKKDQLLMDKLENIAKHRAEKGRAAAVRHEEKKGVQKSSLQDPKLQELQEKLEARKAERKRESDKLARTLSPKKATSRRQKELEREKASIEKMRWKELEETREKAAKLRGDGLSSRTSAGVRPVTNLRSQHTTAKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GXA9</accession>
    <name>A0A6P8GXA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116286511 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116286511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548904.1">
        <property type="nucleotide sequence ID" value="XM_031693044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GXA9"/>
    <dbReference type="GeneID" id="116286511"/>
    <dbReference type="KEGG" id="aten:116286511"/>
    <dbReference type="InParanoid" id="A0A6P8GXA9"/>
    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900029">
        <property type="term" value="P:positive regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF22">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="277"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031548904.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47404" checksum="0CFC1E49F9854810" modified="2020-12-02" version="1">MAFCCSMVSEPASVVYKLKEAKKKRIATLRPLLTDGIVPDPAPKGEEDDDTDSGISSHGTASNGNGSIPSPDLSKTELARRLSNASLRDPVHLKAKVLWDFEPRLQNTELQVSKGEIVHLLYRDSDKVLAMNSLGKRGFIPFNFCSLPHKKIDANLSRESVCMPSNPARKQRKQSCENASFKEFLDDMDLLNKKSFTRKHALSSKSHNDFKRLQTKSFSEEGIFGTQSSSSDSEDESFYRRKTSGIPDHQHMIFWNRKALERFRQQKKMNVSHFRKCNDMYMLVLYNFFAQDENDINVYKGDIVRVLNRDDRDWWWVATRSGCEGFVPSSYLTRRSVVPSSGPSTSCSVESSSSTSDASSTQAVRFQDPLCTFHRYEKEEWETDSEVSVRNTGRSLVGIDEHKSIDHSSSSRWSTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H074</accession>
    <name>A0A6P8H074_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Digestive cysteine proteinase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549819.1">
        <property type="nucleotide sequence ID" value="XM_031693959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H074"/>
    <dbReference type="GeneID" id="116287294"/>
    <dbReference type="KEGG" id="aten:116287294"/>
    <dbReference type="InParanoid" id="A0A6P8H074"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000087">
        <property type="entry name" value="Counting factor associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="254"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="338"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031549819.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="62559" checksum="2A8CBDDE4EFDF508" modified="2020-12-02" version="1">MCFEAERISRATMWKICVVVGFIASSFAVAKPTISKEPPVWPKAYTVTGVLYLPYAEIKEPFQAWYDAGNKRSRIDYYGGMDSTYQRGDVLSYGSSYRICPETTETYKNVRKCFQTNGTTAGPVVQQSVLPDLSKFTFMGNTTYGEVSCLAWEYIMYEGHKKNKYTMHVSMDDTLTPIHYEMLGFDSLLGSHYDKYEIVYADYSAETPSPNVFEIPEGMVCTGFPGPGDEATIIANPMQEFIEPEGRNIMHSVFDNFLKNHPKDYADKREYHHRRETFRQNLRFIHSKNRQHAGFYLAMNHLGDRTDKELKVLRGRRTSKGYNGGLPYKPDLSKLKDVPDHIDWNIRGAVTPVKDQAVCGSCWSFGSTGAIEGALFMKTKNLTRLSQQNLMDCTWGYGNNGCDGGEEFRSYQWVIKHKGIATEESYGQYLAQDGYCHFESAKVGAQITGYVNVTSGDLNALKLAIAQQGPVAVGIDASHRSFSFYSYGVYYDPKCGNTPADLDHAVLAVGYGTMDGKPYWLIKNSWSTHWGNNGYVLMSQKDNNCGVATDATFVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0G3</accession>
    <name>A0A6P8H0G3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116286763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116286763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549198.1">
        <property type="nucleotide sequence ID" value="XM_031693338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0G3"/>
    <dbReference type="GeneID" id="116286763"/>
    <dbReference type="KEGG" id="aten:116286763"/>
    <dbReference type="InParanoid" id="A0A6P8H0G3"/>
    <dbReference type="OrthoDB" id="5964434at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549198.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18942" checksum="AEFD62CDA7983AAB" modified="2020-12-02" version="1">MAKRHCFISSNCQWLFVLLFLINIYFGRTISSPTITPVTRNISSKSEVGQLSTMSPKIRQTLCNEPTESTSTLVTKNISVEASTPPSRKAGCLRSNGASCNTYVGSWSYFYLRIGGWLMLGIVLVGIACLLITHFLGMKKARKDPRRKRTLSRLTWTDAKTKSMLANWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0L4</accession>
    <name>A0A6P8H0L4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116287433 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116287433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549974.1">
        <property type="nucleotide sequence ID" value="XM_031694114.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287433"/>
    <dbReference type="KEGG" id="aten:116287433"/>
    <dbReference type="InParanoid" id="A0A6P8H0L4"/>
    <dbReference type="OrthoDB" id="6434782at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1528"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1556"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1963"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="2058"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="2229"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="2271"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="2374"/>
            <end position="2401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="799"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="860"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="931"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1674"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1738"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1803"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1866"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2140"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2451"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2512"/>
            <end position="2657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2689"/>
            <end position="2713"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2814"/>
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        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
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    </feature>
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        <location>
            <begin position="589"/>
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        </location>
    </feature>
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        <location>
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        <location>
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        <location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
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    <sequence length="2912" mass="325337" checksum="C02C68F6DEA49389" modified="2020-12-02" version="1">MDPSNFCIPHDVKIKKEPIDEDEESRLDLSHFENEWFEYKCKSGDVLFYFNIITNEHRWMENRCTCYIENGEELTSKSIGIQCDIEDKSKHVLSKDVSTEIEFSLFGVQESRIGVSVQTEVSFLQENMSLIDKGVTNFSEEESILSLIHENKELEELVNKLVLNPEEVTTELTLTFDGSPVNDKHSDPNKDDGLNNEGNAIALSQLDEGPMKNKHSDSNKDDELINEENPNVLSQLDDGENLQESNLDYGNSHKKSNLDDGNSHEKDASLKNQSDGKILSEESWSASSCNTASERDEGKSAERDNKNTGLNDIASEERNSKDRDRISSPTFYSDKTGVIEKTSSKDKDLSEDERRSEENDVSNLSQICENFSEKESSEGFSYAEPHYPSKDKLCKEGTGNDLRPSEISQEKNLDTPPLDSVEKDSQTEDSCPTFEHFIDEQSFDNTTKTSENSPVDVCNLENEKPKRDQHQKLETNATLVSCQKIRRQTARKSADSLRKCLLIQRKAAEFSNLENSYNNKRKCLRKRTLKRRRCADPFSKCLKVLVTPLEHDLPRIEDQLTSMCNTEYKRQFQTELEECASMSELLSSNAADGSTNSDMPLPNLKNSESTSTKPLNGAGLVPDTTVGETRKICLAVTEHDLTKLSEIKGIGNCSSEGFVETNSFIVLHDSNESQSAVILETTNNRKDISEHLDSSDTDMSQSGFDLKANDDQCAQSSPEKQTTQTTQTTQTTLRNYFCRKRKRKRKFGTGKCLNKKNSLDTSIIASDHSNTQQPLYVDNAEDVDCHFIDGCLIERNEKRSNDDKAKENEYEYSNGHHNPENKSEDLPMDGDHEISKKNHQVFEQNIKNEIQGDADELEPQHNTINKRDNSSGDQSLMDGDSQVSKENQIGEKYIEDEIQGETGERQPHNNPINKYISSEDRCLMDGDDLVSKESQVSEKHIEDETQCEADERRPHNNPINKDISSEDRSLMDGESQVSNENQVVEKHIEDEIQGEADERQPHNNPINKGTFSEGQSIMHGDSKVSKENQVGEKYNEDEIQDEAYEDRPKNPGKDRQVDFSIMETKDIHDKKNKGFDKEDVHNAQDKVEEDSQIPKHHLEDIPMLDESRMVFNGNNWQDRNDDNNESETQNKATQTNQHLEDHLRDLCMKEENEEAAKGNESQNGNVEKNKENEAQNKKSKDKTENLENNQENLSMAGKIHQLSNGIEIENENSVKNDEGKSENKTDEWKENDEPQQQDQGSHVAVPTLKYGTGGIPNETEHIKRFSDGSKKEKDETISKSESPSQEKLSQDDIHVLETNVNDVPGSNNVPGSNAVPGSNDVPGSNAVRGSNDVPGTNDVPGINAVPGINDVPGSNDVPGVNDVPGSNDVPGSNDVPGSNAVPGSNDVPGSNDVPGSNDVPGSNDVPETNDVPGVNAVPGSNNVPGSNDVPGSNAVPGSNETEQVIQGKADICTVMEECNLQDIISERGDEGTSLITDSQSDVLNTGFKPALMEKVSEVTQKTEKDVPRDSDVNSKSKRNPSTRRRIDLSCKLCAKRFRSRFRLSCHLRGHKLEKTKTCHLCLRTFRSHALLLDHMKYHTMVSKHRCSYCKEYFVSHQKLVSHFIKCRETKYTPQNSNTDTASEVSSSEASALKSDCQLDNVSSPATNELTLKESYKYLDNYITNRKSKVKSVLADATGPTGSNEEVTESHTITESHPITSGDSLEKNVETPLNCSVCRMQFKMEYWLNRHIEKKHGMSAKEGSTVLEDGTGPTDTPDEVSGSQTITGDSQDKNVETPLNCSVCGMVFKMEYWLNRHFEKKHGMSAKEGSTVLEDGTGPTDTPDEVSESQTITFDSQDKNGKTSLNCSVCGMLFKLEYWLNRHIEKKHKKSAKESSTETLSPETNEGKTNKSIDAEKKPRFFENHPSPKKMAKDATVIKDGEINKTFETSKCTKKSQEKPAPPQGRTESVTGNEPKHSEQKKIYKCDICNRDFVYFGSFENHLKHKHHGLDNKNATNMDTASKEEVAETSKGTNLKTGFEVKDNAGKAGKAGKAGNSFLETEVRSNNDNVVIGYKHNTFKCCECPQEFLHLDDLLRHNSDEHAARKCPHCEVSCSSAEELNSHMQMHRRQAATHSMNKICCKICLKEVSTALELITHFRTHKRGRKRRINESQEEEKEGPRFEEQSTSKSLETTGSTSSDDPSSKTGIDGSVSQESEEKLSERAIPNVSKSGNEVIGNTTMKNSIRLSVFCCFLCNKAFSNIRKRSLHMKRSHSKKNIQRDPELSPKNWFLHKCSICGRVFRKTKYYEKHKQEHEDMQTTVSMTNKAGPSFVTKNNSDVNEGSQNSSERIPQDTVVSKVPAINKDLGFDPSTERCVSVNTDVRMKSYKLLRRRHYLCSICGRAFYSLKKHNQHTLEHEDMQQSVSSYVPKNTSSCISTDSLSSKDTNTSSILNNIDLGPSGDLVAHSPVIPKEMTRQEKVSESTEPPYSSKNPSSCISTDNLSSKDTNISSMQNNIDLGPKCDLVAHSPVIPKEMTRQEKLSESTEPPYASKNPSSCISTDSLSSKDTNTPSMQNNIDLGPSGDLVAHSPVIPKEMTRQEKVSESTEPPYSLKNPSSCISTDSLSSRDTYTSSMQNNIGLGPSGDLVAHSPVIPKEMTRQENVSESTEPPYASKNPLSCISTDSLSSKYINTSSNQSNIDLGPTDSLSSKYINTSSNQSNIDLGPSGDLIAHSPVNPKEMTRQEKGYDESTCQDKNGLWTESRSASVCSSKTTSRESSTNESQSVLRYLNLETHSCGTLVGKRYRCCYCSLSFSSFYQRDSHVFAMHEMKANQSHLQKGSYSPTEANQGPKRQASEETSLEMLVDGSMDMEELFNSGIKDVNENDETMRKKYHRPNILRRSRPLGKDALFRDDAFSDQDNGLLLETTSTRSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H117</accession>
    <name>A0A6P8H117_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116286910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549363.1">
        <property type="nucleotide sequence ID" value="XM_031693503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H117"/>
    <dbReference type="GeneID" id="116286910"/>
    <dbReference type="KEGG" id="aten:116286910"/>
    <dbReference type="InParanoid" id="A0A6P8H117"/>
    <dbReference type="OrthoDB" id="5987625at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="2">
        <location>
            <begin position="57"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549363.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24345" checksum="3885AEEEBD65ACBE" modified="2020-12-02" version="1">MSDTDDSASSRASGESEVESEAENFVDNIFQPYQHEPLASQDEYENDENDEHDEDGIPYATLEARVENRDPVSNWCKCGHCNVENVLVSREFRCCHEVRPAIGLMLFDASIERHSCITQHEDFASLVNRTVLKQAGPLFREKNGRMYRRKGNQSENEYLRAVAYRWLIRWLCGHLGWDNSRPLSACLYHYIRTTFPSTNCHGYAGSRERSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H720</accession>
    <name>A0A6P8H720_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Growth arrest-specific protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116289417</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552193.1">
        <property type="nucleotide sequence ID" value="XM_031696333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552194.1">
        <property type="nucleotide sequence ID" value="XM_031696334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H720"/>
    <dbReference type="GeneID" id="116289417"/>
    <dbReference type="KEGG" id="aten:116289417"/>
    <dbReference type="OrthoDB" id="206130at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21204">
        <property type="entry name" value="CH_GAS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF13">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="46"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="200"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031552194.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34143" checksum="9FA6EA6B51F96B2C" modified="2020-12-02" version="1">MSTQTANENGEMSKKNEKENIEPNDENDELEAAEKNACDRFYNDLDPLKEDLAEWLSRVLEVDIKPDKLLSYLDDGILPCKLAQIVQKAAEVLVKTGKKFKGPNLPVFSMKYHKNAKPQTFFARDNTAHFLKWCKEIGVQDSVMFESDGLVLHKQPREVVLCLLDVARIAAGVGIEPPNLIKLEKEIDQEIAEDEKKIVKPKEKKSPKALSVESEVARLAAKYNVSIQRIKEGRYVVEGKINIFVRILRNHVMVRVGGGWDTLEHFISRHDPNKIGKILTSTAGTCPSHHHGDLQSKGAAHSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H783</accession>
    <name>A0A6P8H783_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCL-interrupting locus protein homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551351.1">
        <property type="nucleotide sequence ID" value="XM_031695491.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H783">
        <property type="interactions" value="872"/>
    </dbReference>
    <dbReference type="GeneID" id="116288672"/>
    <dbReference type="KEGG" id="aten:116288672"/>
    <dbReference type="InParanoid" id="A0A6P8H783"/>
    <dbReference type="OrthoDB" id="76173at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031023">
        <property type="term" value="P:microtubule organizing center organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058559">
        <property type="entry name" value="PRM_STIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026123">
        <property type="entry name" value="STIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057731">
        <property type="entry name" value="STIL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15128:SF0">
        <property type="entry name" value="SCL-INTERRUPTING LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15128">
        <property type="entry name" value="TAL1 SCL INTERRUPTING LOCUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26399">
        <property type="entry name" value="PRM_STIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15253">
        <property type="entry name" value="STIL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STIL N-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551351.1"/>
        </source>
    </evidence>
    <sequence length="1378" mass="153791" checksum="AC8A489ACCCBD99D" modified="2020-12-02" version="1">MACIQPPTNNRKPLPVISAFFPNANKEEQKSEKLPGYTKDNSEKVVIQPFHFPPTKQIWWDRKPQGTSELLHLSSRRNFRLLVNEKTIRLAIKHFNQSSSPYECFLIGSISIDSREEAVDINVDRFDPGRDMIEKKGGTKRKIPTTVVPGDQIVPLTLIKGLSGADNSTTHSKKEFQRTLEILHSRISGQDTLNLSNFLSLKATCHAHVDDDEMILNLHFGAVSIVTSVVATPVSPVPIIPTALARNLTGPLKLSNVQGTPKCGFLTMDHTRKLLLLLESDPKAYSLPLIGVWVSGPFTIHHPYIWACCVRFLHSTVIQERVLASPNTFLLVHYSPAQTNPIFWECSPQVQLDKGLFELYSSYENLHLDEISSPKYTEPLCFELISAGDTMNRAVFNQAVSSWTKENENHTNENPASLESKASISNNIVNLEPRPSPLPHPQTTQSPLLLPTVPEVSLSLSFDESTFSDHNPHFNGRNQDRQVFSIEKQPIFPGRDGRRILPLKKDDQVILRRNPNKQDQENRGDPRHVGKQVLIDRTPVSSPQREPLRPITGQVNHLQNPAVRVPGIDNDVPGPKGHVVPVGKGHAQNRAVNRGHPKSSWNAPKAKGPPKKVSRDGAIYGRGRGSTIRTRESESTSLKYEVKEMQDVGNVEAQGKSVMTSHEEGRVPLVGIQDQNYPKKDKTPPRSNRSEGHNSIERNGNANNVQITYGRNIDPRVEEQHASNNNSNRVPGIEDTRMPYLVESRQENHHHHYPSDAGIDDNEESKRLTNPSQMPQINARTFHQHQPNDQGINSKHNESGMENSAFCDSGVGNSTRDTTQPDEDDDEGGISNQDAGSSCGKKDVVNETRRDPYDLIMRQQQQLKELQHQINLLLLQQSLTQNSPVGIPTPPPTPVSPDNPCVLSSPVRPRDTMVTMGTNTGASLLIGSPVLGRGKISVGTSPMREVGRNEEKRRRLRSQKRSPSSSSKTTSGSPSLTSTSQSSNHHQPDGTLPRESTPSSRESLDGTIDDDELDEKGLVLERLDETNITLASSIHGVDICEFVGSPESTRGQRRSSDSSPVLGESASMMMQQQDEQQHQQQRGIETPDEDHRFESLLYKNEKLFYDNLLFKVNQLLCENVGKSEETPNTSHDATQSSNQQEAKNEENVIHEPTRQEVLMATVKELERMKERDEADGHDDEKTKAENEYQKYNEPRFRSSLVGILQDHPHINYTSMTVDETLDETILDTETLALKYLNQEQIQEYLQLSSNRHGNQGRGPTRAPNNIGGFNNGRLINDVDCTWNNLSMATQDYLQRYNLVGCKKTTNPTRNGDGHVMGTQAPKPRDGDCHGSSTQAAELSRDGSVASIQCSAPPSTPEPRQTETRILDIQRLRNLPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7C1</accession>
    <name>A0A6P8H7C1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116289500</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552304.1">
        <property type="nucleotide sequence ID" value="XM_031696444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7C1"/>
    <dbReference type="GeneID" id="116289500"/>
    <dbReference type="KEGG" id="aten:116289500"/>
    <dbReference type="InParanoid" id="A0A6P8H7C1"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552304.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30588" checksum="0315B5A574E482B9" modified="2020-12-02" version="1">MIFKMAAARSLNCGAPISSVCCFVDGVLANNGIKHLAARGISTTSVFMKNTPRTVGVPAWAKAAQRRRRSLIKLDKPKTVEQIEAEYRLSNETNKLDFFTTTKNSRPQFSEVENEDEKPQISLTRNKTAFVCYHPPRKDPNALLFSKEAFERPWWHLTQDEVKDFKDSLDPEEAKEVKELRQKDPKIWTVNSLSRLFKVKPLAIVKIAPLTDEQKYEIEIERKLLKQWSDYKRKEYRANQELERQRYIQETRGEAMNLALGIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9J4</accession>
    <name>A0A6P8H9J4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Osteopetrosis-associated transmembrane protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549407.1">
        <property type="nucleotide sequence ID" value="XM_031693547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9J4"/>
    <dbReference type="FunCoup" id="A0A6P8H9J4">
        <property type="interactions" value="884"/>
    </dbReference>
    <dbReference type="GeneID" id="116286950"/>
    <dbReference type="KEGG" id="aten:116286950"/>
    <dbReference type="InParanoid" id="A0A6P8H9J4"/>
    <dbReference type="OrthoDB" id="8021850at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019172">
        <property type="entry name" value="Osteopetrosis-assoc_TM_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644">
        <property type="entry name" value="OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15644:SF2">
        <property type="entry name" value="OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09777">
        <property type="entry name" value="OSTMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028386871" evidence="2">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549407.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31374" checksum="E248236FCD446E43" modified="2020-12-02" version="1">MLITYLTVGILSFFALNSAFVSSKHDIIDKNCKKQLEGLAESISNFTRCAVSQASPFKFCRMCYEQYDDVRRNKNEIYKKGGCVSELVESERYQIVSHACEFAKRLWEESNCFSCFSSDHKNEDSIGTKWEIDPKVKDFFNKQQILYDCFKNFTTIPVNPAANTSSANTTSICKFCKPNYEDLNDVYKDLINQVGGYPKENLLCADVMSAMNSTRHKWSSTFGCIKINYDTASVVALTCLFAFLPVIFYSAAKLRGDEVDKKSSYNVIPQISYDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9M6</accession>
    <name>A0A6P8H9M6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LOW QUALITY PROTEIN: deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116289131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551868.1">
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        <property type="component" value="Unplaced"/>
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</entry>
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    <accession>A0A6P8H9U1</accession>
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    <sequence length="195" mass="22069" checksum="C5B2E830F7DA5F78" modified="2020-12-02" version="1">MSTSNIFKMAAAMLQVNGCLEIENLIEFCGIPKQKIQLNPCISDSAIKVPSLTFSSGVTVEGMRTVAVYIASVCQDLQEYGPLLGESSLQRAEIDQWLEYRQTDVEKALRDKNLTKPVLQDFNCHLANKIYLVGNKLSLADVILYYALHGIIKHMMPQEKEMYTNISRWFNQVQSILAARQGLSLITFQRNQLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA37</accession>
    <name>A0A6P8HA37_ACTTE</name>
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        </submittedName>
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        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027873820" evidence="2">
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            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549557.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16235" checksum="3CD67B9C13A1A604" modified="2020-12-02" version="1">MRFFTCLLHASLLSLSLCSFAKEESPRDEEKRPSFMSLDITKFKKEMRVASNKKNVHKKKSEIDNLPEEMIKGIKSIKSKHISYTATKRQLVTNKVKKQARNENKKSIERKRNKVAEIMEELPEEMRKGIQSVKNPVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCU4</accession>
    <name>A0A6P8HCU4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-seryl-tRNA(Sec) kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554254.1">
        <property type="nucleotide sequence ID" value="XM_031698394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCU4"/>
    <dbReference type="FunCoup" id="A0A6P8HCU4">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="GeneID" id="116291250"/>
    <dbReference type="KEGG" id="aten:116291250"/>
    <dbReference type="InParanoid" id="A0A6P8HCU4"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052648">
        <property type="entry name" value="Ser-tRNA(Sec)_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873:SF0">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554254.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40905" checksum="4E1CE0E3BB6BE17F" modified="2020-12-02" version="1">MADNQKNINPVLMILCGIPASGKTHLANSMKKWSRRCKEDKVHVLHICYDELIPVNLDLQTSSLNDQKEDLEFDDLHSSASISAWKHYRKLIIQCVERIAQQIQDITFDLNEENDVVKNTFELPSFQDFWKTFYEQTARKDMSCACLSSQKWIHTAHILLVDDNMYYRSMRHEYFLLARKYGLGYMQVFIECPVNTALDRNSQRGNPIDRNTIVTMATKLEPPSPDKYPWEEYSMVLDANDDGTNSYLTRLLSLMAEAALNPVQPLPEENKEEKEEARAANLTSMMHQADQTLRKVITDKMAKAKGDGFTKQEMRSLAEELNLRRKTFLDKLKTEESLFQPLDNNVGQKSVKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDS0</accession>
    <name>A0A6P8HDS0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290330 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553198.1">
        <property type="nucleotide sequence ID" value="XM_031697338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HDS0"/>
    <dbReference type="GeneID" id="116290330"/>
    <dbReference type="KEGG" id="aten:116290330"/>
    <dbReference type="InParanoid" id="A0A6P8HDS0"/>
    <dbReference type="OrthoDB" id="5986494at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553198.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24085" checksum="0172232680B6B76F" modified="2020-12-02" version="1">MEMRKLVWKQQEFETVTKLYAHCVAFIKVEDRKTVSSSCSSLTLTSTTENKPDHSPTNPRPTGSRVQFLNLHQVYQKVQSRVGRESKQRLVDARVRMVVTFDAQIEGIQIFVERVPEAAALLGDNTGRVELEPRMGDLVLNKQYLSVDLDSVYLSPQGMPVYKLSTVDAEKRNRFRIVVVIKFIDGTKSKPYFSRPFLIRSRRSSRQDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEG6</accession>
    <name>A0A6P8HEG6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Melanopsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116291137</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554116.1">
        <property type="nucleotide sequence ID" value="XM_031698256.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554118.1">
        <property type="nucleotide sequence ID" value="XM_031698258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEG6"/>
    <dbReference type="GeneID" id="116291137"/>
    <dbReference type="KEGG" id="aten:116291137"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF414">
        <property type="entry name" value="LP14436P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031554118.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41439" checksum="C12CB154782A5DC6" modified="2020-12-02" version="1">MNNTSSYNKVQEPLKPRSSVELITLSLSLALIIALSVFGNLLLILSIFKNERLRASFANKLILSLAIADFLTASFPMSYQLATVVNVNIISNGGVVCTIGGLATYSFFFTSTFTMIMLCIDRFVALGYPLHYNLRITSRVKIFMIAYPWVHGSLFAILCGSLLDINFDPKGLDCGLGWHKRPMAFTLSVLMIHVGMPFVLLLVLNTRTLFLVRAQNRQILHYDKKGMTDKSGVINIRAKDAYRKRAKIEFKLAKVSITIVFVFLVCWTPYVVTRSLVFMGLKLSTGILSAGAWVVHASSFANPLIYSSLRVDLRQAMRNVFLRHKVRQSNASVIELENFTAKRAGEQLSASFDSAHKRSPHATKLMLGLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGV9</accession>
    <name>A0A6P8HGV9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116292476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555659.1">
        <property type="nucleotide sequence ID" value="XM_031699799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292476"/>
    <dbReference type="KEGG" id="aten:116292476"/>
    <dbReference type="InParanoid" id="A0A6P8HGV9"/>
    <dbReference type="OrthoDB" id="5990459at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="12">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="782"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031555659.1"/>
        </source>
    </evidence>
    <sequence length="808" mass="88734" checksum="C22F9E11E735502B" modified="2020-12-02" version="1">MLRIVIQHGGNDVTCNPLIWTDFWISTKECCYSSGKLSIQLLDYTNAASRAYDXGCCDNVRFCVSSCDNFFILCLAGVGETDKCSLYRRDTQVTSSDRFSFSTSLGNGLRNPVIYNFTLWQPLKFSVEVWDDDSSNFVGKDSDLIDRYTVNILYSPSPNMXDAPEYRHRLTGRQSAXNIKVKVYCDDFYFAPNCTTYCKARDDSKGHYTCDYSRGRKICREGWYGNDCLVYCQPRNNSIGHYICNEMGQKLCLDKWMGENCTKENSSNIHPSSINSASIGPSHLSSTSNGIHTIPSSPSFTSRKQHYHTETTKSLAKLSKSRNFCSSPISSTLNKNMRTVSIEIKPSDYDPILSVSTSDNGSKLPVSISDNGPILSVSTSENGPILPVITSDIGPILSVSTTDNGPILPVSTXDNGPILPVSTSDNGPILPVSTTDNGPILPVITSYKGPIFPVSTTDNGAVLQTSLVSSTHNGPEWLTLSIDRNITSPTATVHSSHSTSINHTCFVSSAQSTKTTQPLGPTLSNSYDKAKVSSTITTNEIEVPSPTDKALSSLASKESDCRSAALDDDALKLTPVFMEIEMFEPDGRENVIARVKPCILFKINEYCKREREICNIPNCWKNISRVLFGRRQLVAEITNNQAEDQSKMTLQMMAKLPGVSKGIIPPVVLLEILNSAVSDIDKACDVHVLRVWIEDTTDIPSSGLLKNYSQSTSDNSRALAFIAVGACSVVAMVIVFGILCHRSRNIXSRRVKVNPLIDDDSTPPDSPDIXVADKTXLLRKQEFQKSKTSSQLTNEELELTSRIPGSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHJ0</accession>
    <name>A0A6P8HHJ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OTU domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554408.1">
        <property type="nucleotide sequence ID" value="XM_031698548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHJ0"/>
    <dbReference type="FunCoup" id="A0A6P8HHJ0">
        <property type="interactions" value="1807"/>
    </dbReference>
    <dbReference type="GeneID" id="116291379"/>
    <dbReference type="KEGG" id="aten:116291379"/>
    <dbReference type="InParanoid" id="A0A6P8HHJ0"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22770">
        <property type="entry name" value="OTU_OTUD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="58"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554408.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="52915" checksum="8B88C47578FB3CE4" modified="2020-12-02" version="1">MAKGNTVKKKGQKRDELERKRDERCRRKALKKERNIKEYLENDENFVSFKNQLEAVGLKIKDILGDGNCLFRALGDQLNGDHTSHAYHRRNTVQYMKDHRDDFEPFMEDGVTFDKHLAELSKLGTYGGNDSIVAFARNNGVDIVIHQLNNPRWVIHGSEFSKSQQKIELHLAYHNGEHYSSVRRLTDPDDGPAWQYNQKNSQMQSVENPKVTVRKNKKKHERKENQDKSDPSSQANKYIDETSQLVMENTGCQDSELIQHTLQANNYDIDASIMEIIQVMCVLEEQEADVSKGFVRDVIAKTEAIETMATENSVAIEQPSDEYVTRNRQENVGAFVECKSDDVTSRTRLNHDDINDNTKETDKEAFDKLKGDSGELVHDQKTENKLKLHPGARPKENISQKSRNKAPHLTNRQRKDLARQEKKKQREKRRVNERQQQTESETVAQDNVNTIVADLGAVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIV6</accession>
    <name>A0A6P8HIV6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">28S ribosomal protein S35, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552525.1">
        <property type="nucleotide sequence ID" value="XM_031696665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIV6"/>
    <dbReference type="FunCoup" id="A0A6P8HIV6">
        <property type="interactions" value="1251"/>
    </dbReference>
    <dbReference type="GeneID" id="116289722"/>
    <dbReference type="KEGG" id="aten:116289722"/>
    <dbReference type="InParanoid" id="A0A6P8HIV6"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="188"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031552525.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35544" checksum="C598233A2BB7E130" modified="2020-12-02" version="1">MAATSAGKMAVKNILFLGFSTGPGIVNSFVNKALPCCSYGTFVGKAASSMMRSNRASNPRERNRQGRSGTGRKLASNPSRAIKMVPETTDWPSVFSGAQTFNPSVIPVFFRMGRPKHNRIDKKPNRTMGNIELMKVTNFFHLSPPAIERHCEALKSLCKEWPSDVDLSSYPIKVITRNYLFAGPSLYHPGSRKVKLQICLKDLILDDHARKKLIDLVGPRYNPETDTLTIVTDRCPTRKQNKDYALYLMAVLYHEAWKTEPWETDSTQNEEDEDIELPKKKRQSPIRLRLVGDELYRFNKYGKGFKLQIKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ59</accession>
    <name>A0A6P8HJ59_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556424.1">
        <property type="nucleotide sequence ID" value="XM_031700564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293170"/>
    <dbReference type="KEGG" id="aten:116293170"/>
    <dbReference type="InParanoid" id="A0A6P8HJ59"/>
    <dbReference type="OrthoDB" id="347244at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031390">
        <property type="entry name" value="OFCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33862">
        <property type="entry name" value="OROFACIAL CLEFT 1 CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33862:SF3">
        <property type="entry name" value="OROFACIAL CLEFT 1 CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556424.1"/>
        </source>
    </evidence>
    <sequence length="1487" mass="168661" checksum="44A1073625DF9F7E" modified="2020-12-02" version="1">MADNKKDEELDNEVKYSEAVSRESSNLEGEGGSQASGQNVTGEAVQREESFAKKKKGKKAKRQDDDEEPLERGDSFSGPKKGKKKGKGVKKIKQVRVPDEESKQKEQFELGVLEETGRPTDKKIKMETTNIDNKLIQEGQETEIITPKEGTTVKDSXQNKDERLESSGDEKKDSEKESPSDEDNTIKIVAKDEKSDSTEKPDGVKDSEGEEIRRRPTLSELRGASIEGAEESRVAAENLGLVEEDSKDKKDQTKENSPSTDSETQATTTEQKEAEVVIEVERKISKDALTSIKVVSTKQTEQVAVPLQQVTEEQESISVVTKEEQEHIVVPMGEDAGKPDEEKALEVTIETTEEKITTEKTQELSAEVAVEVEAAVENKTESSSEVTAGEKPQEMSAEVAVEVGSVADNSGSPSGVMAGGKEDKDDVKEEESDGKTQTFLEYEIEDELPWAMYRSLDAPLTKKAPVEEDDEWPQSEEEEEYEPPTKEELPDIDELMGKLDGGETELETSAPPPPVIQPEDKAQQQKKIDELKLGLAEEKIDSYLDDFERRMEEEILMIGQISLEEVQEEERRLRDEHISYQQQEAKVQQERIQDIIAREERAKKYIMAKLKEKRKAILRREEHLMQQDRLIQNRIHRAFRRAENQLLKALKARKGEVKTMYGDLILADGQYGGSKGRRWKVDWNRTPQPIQIKLKCLRGVKDKLPGGRYVLMVSLYDRLGGHVLKWSNLKGQQWGGATLPLHHDGEFFNIEIKIDQSVFTVCPARPDVRPGMCLVFELFILRGSVTATDRVVGWGCFPICDGEFNIVEGKYKSPFLRGDMDPSIDKHEKVEELMAQDLENWLCNLYFEVVKLPRYMAGQKEYEVELQFTSGLVGYPARTNTGEEFIDGEQPVYGSRADLKSLASPTSSRRPSRVSMLGGSSFLGSTMDLKGEGKEQLPGSTVDLQVEVPDLSTMPKRKLSLAVPDASTLRRSSVVSQTRRMSSVSTTRRMSKPMTVAMSRKTVEMDMSSEGSGTDYSDDEVLMLKKDDGFNPVKGQPGMYYKKHHNNPVDVYAKKMFTLLPKTPLLTRRKKKKKLTHTEELEQHSFSVKQPFSNKGHIVHRGREKMQYVGRQLMAELGLSQWRSREFWAMMLMIAFTWFLRLYAHYGGQWLYLTALIIPINKFEFLPYTVNLNYQTTLLHTEEEIALVILGPFTNILIFCLLVIAAWAIQRLFGIFPNIFSRFIMALGINILLDPLWIIIVDSALLRYRNVGGDLPIGDAFKLYWHFDRYEKNGAVGIVLTIFLYIVTLFASSTILYMYFLRLHNNGRLMDVYHRLHASEDDFFIPYDLEISNEELNFICKKSEQWRGEEGERRKTAVYDYIWEEEQVDEAEINEGHNQAGRREITTHVSVHTLHLDGLRELYRHFLRLPDGAIVEVFNEINLAGMDEGIKQALIKGTTYQAMDNTTASKTSLRSRGRSSSVVSGTSFRRPSVLLEVPKAARSSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJJ9</accession>
    <name>A0A6P8HJJ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116291950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116291950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555043.1">
        <property type="nucleotide sequence ID" value="XM_031699183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJJ9"/>
    <dbReference type="GeneID" id="116291950"/>
    <dbReference type="KEGG" id="aten:116291950"/>
    <dbReference type="InParanoid" id="A0A6P8HJJ9"/>
    <dbReference type="OrthoDB" id="10362166at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555043.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21507" checksum="FD88573B65BC3E84" modified="2020-12-02" version="1">MLDKETRNNWRTLGSKFGLQRDELEQIVSNPARILLEDYVYQTMDAEDLTNGSFQQLVNVVDKPSPFLRAFEDDCRSMKDVFPPSSEKMWRLCLNLNKSKEVGGMKKWEHLAACWGIKPEIYSQFDPSQKTSPTEILLKWLVDARPDFTVNELCYHLGKIGCHDAKVFLEEKLKEWQLQKEVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK89</accession>
    <name>A0A6P8HK89_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116292179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555308.1">
        <property type="nucleotide sequence ID" value="XM_031699448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292179"/>
    <dbReference type="KEGG" id="aten:116292179"/>
    <dbReference type="InParanoid" id="A0A6P8HK89"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="93"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="430"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="715"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1024"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031555308.1"/>
        </source>
    </evidence>
    <sequence length="1260" mass="141633" checksum="4F760430E95E067F" modified="2020-12-02" version="1">MTNHYEKIPNSKFKPNFFSRIFFCWLNGLFLRGYRRPLTSEDLFPLPDENKAQGLVTDLHELWNIEVMYAQKRGKNPRLWKAIWKLFPMHNYLLIIILRLTEDLMTFTQTFLIWYYLKLLKGNXMSSTHAWLVVTGIAATTFFKILSYHHFGIQTLAMGMRLKIAVVGVVNKKIGESKRSILSSFTSGYILNLVSNDAQRMEQFVMAFPKLLSLLWFLSLIAVSMVFLVGWQSLYGMLVIILILVLVLYLSYVFANLRRIQSGKTDKRLGAISEIISGIRALKMYAWEWNYKNEVQKLRRDEVNTLQLKAFVLSMVNFTQFTVKYWATLVSLIALFYSGIHLDTSEIFTLTILLAIGXQSLEARIGSSARNFRDGIISLIRLEKFLGTSCGPRTAGLGNEVHVSHHQAKNLVHSKMLAKGSRIFDDVPGITLTEVSAAWNVDQQCVLHNVSLSVESNQLMIITGPVGSGKTSLLMAILGEIPKISGEIQTRGRIAYVSQIPWIFSGTIRENVLFGQHFDEARFNRILEICDLQKDIKSFPEGDLTIIGQRGVGLSGGQRARVSLARAVYSDADVFLLDDPLSAVDVRVGQHIFDRCICGELSDRVRILVTHQTQHLERADKILFIAEGFIQQESYPALNNNILLKNQYEQLLRSTGNFDVGQEKFIDSVQRDMTEDTGDQDLRESDEEKASGTVSWRLYWEFLRVGLPAVLIGCLVLFCIVVQASLLIPSWWLSRIADMPFEEQKNPQTLGIFGGLTAFAFVLSLARDIFIFFAILRSTRKLHDKMTLAVIKSPVLFFDTNPAGRIMNRFSNDIGNMDDQLPLRFALAVAFTTDIIGVFILAVVVNPWIALSVLPILMVFYLITTIYIKSARELKRMEAMRCSPVYAHVVETITGLEVIRTSGREEDFVDKLFSIQDDYTKAFFLVTSSVRWYGLNLDLLCGVFNVAVAIAGVTVIQDPALAGMLLSLAMGLLSDTQYGMRMACEVESQMTSVERVMAYSKLPSEPGYGRQKKPPKDWPRQGGLSLRDVSMVYLEGGPCALKSINIDVLPKEKVGIAGRTGAGKSSMVASLFRMPEPQGQVLIDGVDLGTIDIQTARRSMAVITQDPVLFAGSIKKNLDPFDHFTEQEIWTALEEVQLKTKIRNLVGKIDFCVGEGGAGFSVGERQLLCLARALLQKSKILVLDEATANVDYQTDQLIQQVIRQRFDNCTVLTIAHRVNTIMDYDKVMVLDKGHVVEYGNPRSLAGKENGFFARLVNSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKL0</accession>
    <name>A0A6P8HKL0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dCMP deaminase</fullName>
            <ecNumber evidence="6">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116290239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031553140.1">
        <property type="nucleotide sequence ID" value="XM_031697280.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HKL0">
        <property type="interactions" value="1239"/>
    </dbReference>
    <dbReference type="GeneID" id="116290239"/>
    <dbReference type="KEGG" id="aten:116290239"/>
    <dbReference type="InParanoid" id="A0A6P8HKL0"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="108"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="355"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031553140.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60674" checksum="078C7D499565067C" modified="2020-12-02" version="1">MAEEGFAYYKIVQRISKKDLFVCLALWMEESPLVSIDDCGICDGSIVNSKIGDKRKNVELDDXHDLKKVKVLDSDEVNSGSNEIEDSENQVFVEKVDSEHTLKDSMINSPMTDSNEAREVKKLSTESKLNTMGVVIVDSNERIVAIDYTHQGLHAITNAMVAHSGKMQGCVVYASRKPCSLCTKFMIQMGITKIYYLPLEPECPIAEDLNYCEQMYRTCPIAQSVYVPSICKNVIRDSTVKRSPYTPTKPDHVGLVEVLLNKYWNKEWVNILPQLLFWSDYEKISGKVASQMIVMFXWLAKVTLVDVPETTRFKPYELCNGLISGRTDIESHTNDVDNSXRKSAALIVRDSQWQQTALHMSRMAQILAQRSDDPMRGVGAVVLKENEIVAVGWNGFPAKALYGDFPRANDRDENIKDKKYPYIIHAEQSTILSRLVQDINHESTTMFVNKMPCNECMPIILKVGIRNVVFPPERTKQYTTYLHTDLISRCIMAGKINGFISEIYPKNEGQVKVVSKSLQFLETKKDKETLNSNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HKN5</accession>
    <name>A0A6P8HKN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibrinogen C domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116293626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556939.1">
        <property type="nucleotide sequence ID" value="XM_031701079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HKN5"/>
    <dbReference type="FunCoup" id="A0A6P8HKN5">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="GeneID" id="116293626"/>
    <dbReference type="KEGG" id="aten:116293626"/>
    <dbReference type="InParanoid" id="A0A6P8HKN5"/>
    <dbReference type="OrthoDB" id="5951372at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027818731" evidence="2">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="54"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031556939.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30673" checksum="2D451E89EEDE03F6" modified="2020-12-02" version="1">MKVLSFVLILIGLFLVTEGNQVIKRKKDFCFLQPGALKTMEEKLNIIMKILGASNKIGVPKNCAEVLRGGGKKSGVYTVDPDGKGPFKVYCDQKTSGGGWTVFQKRQDGSVNFYRGWADYKNGFGDLKGEFWLGLDKINRLTYQTRNRLRVELEDTKGNSAYAEYDYFAVTSERSKYKPSLGTYSGTAGDSLSQHRGLAFTTKDRDNDSDKSRNCAVTFKGAWWYKACHHSNLNGLYHHGKHKSYADGVNWYSWKGYKYSAKRAEMKIRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HL34</accession>
    <name>A0A6P8HL34_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292445</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031555633.1">
        <property type="nucleotide sequence ID" value="XM_031699773.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292445"/>
    <dbReference type="KEGG" id="aten:116292445"/>
    <dbReference type="InParanoid" id="A0A6P8HL34"/>
    <dbReference type="OrthoDB" id="5980337at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555633.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18031" checksum="CFF89CCEE3494162" modified="2020-12-02" version="1">MSRSLGMPSAPVIPTVIGVTTMKRAFHLGSWFLDNRNILEKIVSNGRTPDSFGTAKKILQXPGPFVTTRMMCRLTHTSTAAVMAAMKKLEKEKLGEVNVDLNCFFKQPPIHVNEANLELYGMDIISYTNEFRKRNGLSDNQWSTLLLNAPQQVEVARYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM76</accession>
    <name>A0A6P8HM76_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290784</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553747.1">
        <property type="nucleotide sequence ID" value="XM_031697887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HM76"/>
    <dbReference type="GeneID" id="116290784"/>
    <dbReference type="KEGG" id="aten:116290784"/>
    <dbReference type="InParanoid" id="A0A6P8HM76"/>
    <dbReference type="OrthoDB" id="5963161at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553747.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="71846" checksum="4229D6E4891FBCD5" modified="2020-12-02" version="1">MESKVFNEVPNLAPCLGDDLNGTSLDEFLENCVEREWDATIQPAQAVPGSMPHIPALDPAELFSMNTLYQAPKIPDVTVSVQVTGLKDSYEKGQSRHKAKSQQRLLNGEVSFTATVSHPLQDIYVYVERVPEAARILQDTTGRVPLQIIWRRGDSNSVIFSVDLDSVYETPDGGKVYELSRVKGEERNIFHLVLVFLFMNGVTREYSSKRFRVKSKAASSKPESRDELEGSTCSSEDQVSFSYDNSPPNRKRKRDELGHGEFSPGSISSGVGSEVSNSFSEVITDHLVAKTAIIGELQINKPMLTERGDIAYHFPLEKSLKDENEDLEEGDVIGFFEDPDGKTYIQKLTYFNAKNVKLAGVISRSAYLEAKANLESAEKDTDEVVCMIGMVKVKVMGPVKNGERIYASLESPGVAVPQSRVCDVTSQDSFLLGQSLETVECKSNDITSPQCFVSIILTISTGHVTRAVNDMRSGVKEDVKSEVKQVKKKCMMGLRRWLLAGFILAVLISVLLYQLFAPGTALRYFMCSQGAIEGSDLYFTFTTVDKQTPRVHGIQFPFAKLKKKLELNFNEISIKGAKYYLNIDRCANGGIRPVSSTLDGLPMVRGAEIVAVNHNCSRVYYHAEKWEPYDTARDIVCTNNEEEFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMA6</accession>
    <name>A0A6P8HMA6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette sub-family B member 6, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557479.1">
        <property type="nucleotide sequence ID" value="XM_031701619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMA6"/>
    <dbReference type="GeneID" id="116294087"/>
    <dbReference type="KEGG" id="aten:116294087"/>
    <dbReference type="InParanoid" id="A0A6P8HMA6"/>
    <dbReference type="OrthoDB" id="5982479at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015439">
        <property type="term" value="F:ABC-type heme transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557479.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34344" checksum="B5E2E12838632361" modified="2020-12-02" version="1">MENMFDLFSQGREVLDPPDATILNVSNGLIEFKDVSFGYNLSNHVVKNVSFKVYPGQTVAFVGNSGGGKSTIIRLLYRFYDILEGSISVDGQDISKVTQKSLRSAIGVVPQDTVLFNNDIRYNIRYGRLDSSDEEVEEAAMAADIHGRIMTFPKGYETLVGERGLKLSGGEKQRVAIARTVLKNPPIVLLDEATSALDSKTERNIQESLNNMCINRTTIVVAHRLSTIVNADQILVLNEGEIVERGRHEELLALGGYYANMWQQQSRKNLKDKEDAEADDDDDDEGDEDDDNALDSDEENKDTGKEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMX0</accession>
    <name>A0A6P8HMX0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557719.1">
        <property type="nucleotide sequence ID" value="XM_031701859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMX0"/>
    <dbReference type="FunCoup" id="A0A6P8HMX0">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="GeneID" id="116294291"/>
    <dbReference type="KEGG" id="aten:116294291"/>
    <dbReference type="InParanoid" id="A0A6P8HMX0"/>
    <dbReference type="OrthoDB" id="5975874at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557719.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27863" checksum="FB8E920ADCE7779D" modified="2020-12-02" version="1">MAGDEGLVFTTLLLIVAVFLRKRSRFLRNLRLLSLRGRQGANLAFLLSIQRRNRPRRRKLAWVYPRPQFWFEELLNNRNLDHLWREHFRVNRNTFDFICGIVGPYMSKQDTILRQAIPVEKRVAIALWRLATGNSYRTVALSFGIGRCTAMNIKDEFCSALMRRVNEFIKFPKTEDETRRCIQGFQNISTFPQVVGALDGSHIPITAPTENPNEYRNRKNFHSIVLQGVADANMKFIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNS7</accession>
    <name>A0A6P8HNS7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase RNF34-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031557331.1">
        <property type="nucleotide sequence ID" value="XM_031701471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNS7"/>
    <dbReference type="FunCoup" id="A0A6P8HNS7">
        <property type="interactions" value="3396"/>
    </dbReference>
    <dbReference type="GeneID" id="116293969"/>
    <dbReference type="KEGG" id="aten:116293969"/>
    <dbReference type="InParanoid" id="A0A6P8HNS7"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16500">
        <property type="entry name" value="RING-HC_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000110">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057299">
        <property type="entry name" value="RNF34_RFFL_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23632">
        <property type="entry name" value="SAP_RNF34_RFFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557331.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37651" checksum="317C2C231E6B4C41" modified="2020-12-02" version="1">MGAGGLNGELRDNREYIESILNYHYNTSNQSGANRASGSFRPQQQPPFTSPNTRPFPSTTSNLSNSYSYNIPSAEMVCYSCNVSFTLLRRKQTCNNCKRAFCKECFKEGLSATDQSCPNCLTCRSLNAPQSHKEFLVKIKVKDLQEYLRKKNISTHQCKEKRELIELVLNSSPAGTQNVSFPRNTQRQSYSYSSNGSNTRNRAPSSDGEVAPPNTKKAPPKTIDDITSIDQVSSLSIREIKQILTVNCVDFKGCCEKEELLQKVRMLWKSRNDSKKIGDNDEDSEDICKVCMDRAIDCVLLECGHMVTCLQCSKQVAECPICRQNVSRIVKVFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPK4</accession>
    <name>A0A6P8HPK4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable E3 ubiquitin-protein ligase HERC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116294134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557536.1">
        <property type="nucleotide sequence ID" value="XM_031701676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPK4"/>
    <dbReference type="GeneID" id="116294134"/>
    <dbReference type="KEGG" id="aten:116294134"/>
    <dbReference type="InParanoid" id="A0A6P8HPK4"/>
    <dbReference type="OrthoDB" id="5980715at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031557536.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17254" checksum="6189E2C9CA3EB583" modified="2020-12-02" version="1">MNEIGSLGDIVMSNATFFDEILSDKEDDLTLVTFKKLYQVCYSDVGSNRRQEEEQAMYSFELFLQDLAEGETPELKLSDLLIFLTGAERIPPLGFPSSLVLEFYDNIDGEKRLPWASTCSLTLHLPRQNNSPEELKCLLRQSLQDCQGFGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ40</accession>
    <name>A0A6P8HQ40_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear polyadenylated RNA-binding protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116291726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554795.1">
        <property type="nucleotide sequence ID" value="XM_031698935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291726"/>
    <dbReference type="KEGG" id="aten:116291726"/>
    <dbReference type="InParanoid" id="A0A6P8HQ40"/>
    <dbReference type="OrthoDB" id="5982676at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031554795.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="29385" checksum="F2F7A17A12FFC2E0" modified="2020-12-02" version="1">MAPFRWPLQMHDLMLAQEVAAHKPSGKAEWEEIAQTLSKVFSKEDKNVILKGRGCREHMERLLEKYRDEDKKALKRSGTEEDYNELCQLLEDISTFRXDLEEQKIKEKENKKIKEKSDKQKGLEMRAAALSTMKKRKLDDQESSGSDIDESDEDDINDGDDDDDSSSSAKKXSKVKTGPRKRASRLSAIEMLGNKYSKKADYREKELDLRRQEFDLQKKKYEDERAEREEKFKLELEERRVFLSFLKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQD3</accession>
    <name>A0A6P8HQD3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NF-kappa-B-activating protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116291816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554890.1">
        <property type="nucleotide sequence ID" value="XM_031699030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQD3"/>
    <dbReference type="GeneID" id="116291816"/>
    <dbReference type="KEGG" id="aten:116291816"/>
    <dbReference type="InParanoid" id="A0A6P8HQD3"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="218"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031554890.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37863" checksum="7F0475CCC12A5C68" modified="2020-12-02" version="1">MTREELHSHRHRSRSPGHSRRHRKARSRSPSWPKSRSRSRSRSRSHSLEREHFRKKQKSSEELAMERRRAMREQIMSDGVPEVWGPVPREQPIDSDDERKRLHPTLANGRKSKKDTDSESEEEAPKKKHKKSSKKKKKKHRSKKSRKHSKKRKKRKESESESEEESSDGSELEWEEASVDKVTVEKKQIKSKKDDKEEESEVVGPLPIMQDGTTPELRDFGGALLPGEGEAMAEYVKMGKRIPRRGEIGLTCDEIASFESSGFVMSGSRHRRMEAVRLRKENQIYSADEKRALAMFNYEERSKRENKILSDFRELVHQKTKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS57</accession>
    <name>A0A6P8HS57_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC116292341</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555490.1">
        <property type="nucleotide sequence ID" value="XM_031699630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031555491.1">
        <property type="nucleotide sequence ID" value="XM_031699631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HS57"/>
    <dbReference type="GeneID" id="116292341"/>
    <dbReference type="KEGG" id="aten:116292341"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000016">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="189"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031555490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031555491.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27885" checksum="7DEF59F7045E4C22" modified="2020-12-02" version="1">MTHTSESRIGEIFSFSGIENLPFELQRNFTLMRDLDQRTQDLMKEIDTLSEDYVSGVREMDSGQRTDHLKKIEIAFSKSKEYVDDKVQLAMQTYEMVDKHIRKLDSDLARFEMDLKEQKAKEAGLSDYEEEITPPKKGRGRMSKRKADEPAKKKKKRDTSPAKSLGVTATLFSPEVVQVLDMPVDPNEPTYCICHQVSYGEMIGCDNIECPIEWFHFPCVGLTAKPKGKWYCPKCAQERKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSX1</accession>
    <name>A0A6P8HSX1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292572</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555775.1">
        <property type="nucleotide sequence ID" value="XM_031699915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSX1"/>
    <dbReference type="GeneID" id="116292572"/>
    <dbReference type="KEGG" id="aten:116292572"/>
    <dbReference type="InParanoid" id="A0A6P8HSX1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052745">
        <property type="entry name" value="G3P_Oxidase/Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720:SF1">
        <property type="entry name" value="GLYCEROL 3-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555775.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33076" checksum="D4A8D19E04F2506F" modified="2020-12-02" version="1">MLSAEEVRHKEPFLNPEALGAVFVPREAIVDPWSFSVSLALLGISQGGKILRGCKVEGGKRKPEGFWELSTSQGLIEAKLVINCAGLFGDIVEEINRPSPFAIKPRKGQYAVFDQSAQNLLNSIIFPVPTERTKGILVFPSVYGNIVVGPTAEDQSDRNEAKIDEKVIDTLVERAYYIVPGLREHKVIGTYAGLRPATEHKDYQIESLPQRNWITVGGIRSTGLSACLGIAKHISSMLLSYFPSHPTSDTPKLNVSGRQFCENEKTLVFEDQKFMVTHPLTRFGINTSTGLLKFKSFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT27</accession>
    <name>A0A6P8HT27_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116295769</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116295769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559544.1">
        <property type="nucleotide sequence ID" value="XM_031703684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT27"/>
    <dbReference type="GeneID" id="116295769"/>
    <dbReference type="KEGG" id="aten:116295769"/>
    <dbReference type="InParanoid" id="A0A6P8HT27"/>
    <dbReference type="OrthoDB" id="5987925at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046616">
        <property type="entry name" value="DUF6729"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47773:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47773">
        <property type="entry name" value="SI:DKEY-9I5.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20499">
        <property type="entry name" value="DUF6729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027605745" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="657"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="CRC" evidence="4">
        <location>
            <begin position="824"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031559544.1"/>
        </source>
    </evidence>
    <sequence length="1059" mass="120240" checksum="5C35A1266AA4DC2E" modified="2020-12-02" version="1">METKGYMWLLFTVLSILATSSLSITLEAHIGAYIRELLQEFKNDPTSSRFDSVIHPKLLGKGKSDFFLPKVFIWSPMDHFKSTIRCPEHGSVLEAMQWTDITEKKSPRNPRLVYDLHGNYLLIQRFYKCRHGQHKYLSAAPEIMRELPGVISHGCFPIKMLYKAACSKELMDLVISEVVQGVNFLQISEGIANLNYKEFCRRGERYLMSNSNNHEKQSCDHDFFTEDFYCDTMFSFPSNDLLMKLFLEDFEGEKKYYDEELRKTKAKVLSFDHTFKVSKHIGVARNGDSQIVGQFSNLFIGLNENKDIVIWKLTRSTKFEEVKDVLVELNERIIAENERIETIYVDDCCKVRAQYKTIFRNKEDIKLDLFHGVQRVVKTLSKKSEASKRLANEFGLVFRANGDLGNVRNLPTPDPEQIEENLDHFEWAWSEILLSKEYTETRNEIDKLKVHIRKGCLSGINPGEGTEGNEVLHHFINRCLLCGSTTIGPELAIAVLTILFYSLNSKKKERKHERNARTNIYMPIEGVITKNYGLEHKKSLTKKVLQEDNSRKEKGCTTTDGKECSKDSSVLLVADHIQNLCNEVIAETILNHVETMHSILDRINKECNNRSFNILDFPILQLKGLQNVIDHFNNDGSSIEETTTTNQLARNLSGLGLEVDDVDGDGDCAFTSIMKQVIDLSLRTEGEVRDRLLLHLEVLGLNTQSVAENVNPLRQLFVDHLCESANYYAQVLGMEENELLAEAELFKRAGTYNYQVGDLVVKVCAEVLNLAIVVITSIDGAPCIPFIPPRLCCDCPIYIAFTHSGPGHYDATKALKHCEGSKEIEKGCSCGKNKSSIDGSACDVSDKTRCPCVRRGKMCSRLCRCRKCNNVMESNAVRQTQEEVKRLNDVSFACSCGRSKKNKDPAYEACKDGERKSKCKCLKYGVKCSATCECYNCCNGKSDKEKEETPSKKRRCRENPSPYKRRKGMQFLNEESLGVHSGSWTRFETYVLIESVSLISTTSITAKPKSLASLYNYVAKYANAKDNKMHMAMKTASQINGKLLHIQSVQDISELLQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU04</accession>
    <name>A0A6P8HU04_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116292962</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556180.1">
        <property type="nucleotide sequence ID" value="XM_031700320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU04"/>
    <dbReference type="FunCoup" id="A0A6P8HU04">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="GeneID" id="116292962"/>
    <dbReference type="KEGG" id="aten:116292962"/>
    <dbReference type="InParanoid" id="A0A6P8HU04"/>
    <dbReference type="OrthoDB" id="10063829at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031556180.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="13212" checksum="8CD2957194FB8860" modified="2020-12-02" version="1">MMQHEMSLLQTSKMAKVTRIMEIWRNFLVGRTLIVPHRYADKMVKRTQPDPDLPDGPAHKLSANYYYDRDLRRQAAPPKVVYSQQKLIETKEEDRNLEHSIPTAKLPGHAYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU11</accession>
    <name>A0A6P8HU11_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296066</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559879.1">
        <property type="nucleotide sequence ID" value="XM_031704019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU11"/>
    <dbReference type="GeneID" id="116296066"/>
    <dbReference type="KEGG" id="aten:116296066"/>
    <dbReference type="InParanoid" id="A0A6P8HU11"/>
    <dbReference type="OrthoDB" id="5987096at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559879.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25761" checksum="9FB70908F1E91048" modified="2020-12-02" version="1">MSEEEVKNTIDELFESALLSIQEPRYEFVRAIGNKIISVPNGPFTGKLVKYLSKQGPVYIRAKKDILHDGGFKRWYKAGEIEIDDDTGSSDDGSHDDGDEPKSKKPKSQVQPSTGKQNMSQDSRTSASTSISTNDSESSTSCSYTNYCNIIVGDAILDSDDENLQLMAIDENLSDSNKEMNGSKDQFWITDQQQDASTRTKKFLSKLQDNGKLEARLMKALVEVGEEGCHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUA9</accession>
    <name>A0A6P8HUA9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNL-type zinc finger protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556207.1">
        <property type="nucleotide sequence ID" value="XM_031700347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUA9"/>
    <dbReference type="FunCoup" id="A0A6P8HUA9">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="GeneID" id="116292976"/>
    <dbReference type="KEGG" id="aten:116292976"/>
    <dbReference type="InParanoid" id="A0A6P8HUA9"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="5">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031556207.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17227" checksum="56F093799F13749A" modified="2020-12-02" version="1">MAASRVRVTCRMLSHKLVTPQFLPKKTIFYKSPMTKVTSSSYSANFKRFFCENAALGKMDVEKFHLIYTCKVCNTRSKKTISKQAYTKGVVIVKCPGCENNHLIADNLRWFYNEKRNIEDILAEKGETVKKQVSDDCTSEILLNNESKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUH4</accession>
    <name>A0A6P8HUH4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 57-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556247.1">
        <property type="nucleotide sequence ID" value="XM_031700387.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUH4">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="GeneID" id="116293007"/>
    <dbReference type="KEGG" id="aten:116293007"/>
    <dbReference type="InParanoid" id="A0A6P8HUH4"/>
    <dbReference type="OrthoDB" id="5973780at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045931">
        <property type="term" value="P:positive regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042481">
        <property type="entry name" value="CCDC57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46725:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="964"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556247.1"/>
        </source>
    </evidence>
    <sequence length="1085" mass="126379" checksum="5EE82281FD83B449" modified="2020-12-02" version="1">MAKSSNIDSNLSLVELVQQKEKEWREAQDLRVKSLEVSLKEQEKLLNNERLRFKKLREDFEYNLQLLSERDQELERYDQIFAKYKNIESERDGEISELKIKMDDLRSKLLQEENAREELQKYYQKRLREHQQEMQQFVIAKESEVKKERDNLERFKRELQHQIRTVEEDMESQRHLLMSGYDDELHKRQHEYRIKLDEMSNRLLEKDLKVKMLTKEVEILRSYEERTKTELQTTETSVQELEKKLKLKEWELMDKENMNAAKLSDTESKMEQMQASMKKSQAIFEHKQAELDRYAREKETALLAAKETHQQRERQLEDTIREYQDKLDTVEVEYRQLEWENKDIMKDKDMKVQRLQKKLAESEERLSSQAAEFSRSTVSKDLELEALRQQEEKLRMDVIQRTEDVERYKKDLSMASERESSLERAKTQVELDWQRRCEDAERAAYEKQEGLIRNLTRAKDEAVAAVKEKDRELNQXENLIRILTETRDQALATLQRHGLSVPMHLPDKEIPGDEVLGREHLTNEDDVEELQRQNQNLRDVIRQMRQDMEDLNNQLASRPPSVMVTTLDEDQEQSSVPLTSEYVKSLEKEVIELKSKNRSLSKRLEDLTLSHKPPQGTGHSNKQARVLGKIDDPFVQSHVKELNDTIGVLRQDKLHLTAQVRKHEATTAHLQGLVASTQDQLRQKQVALDQAQYDLTTLTRRTAEESNAQRQRMLELELQLAQVRREADEYFKSGLERNLEATTLGNQLSVLKLELASQGKSTATFNPQTAVVNELQDEIQRLRKQPGVSPRSHADPSVARLQQKLKTAAQRITQLVREKEQLIQMGNKLRAELSRVRGEDMKGSSFMRHAADHHRPRAPSTPSPVKLTPDEMADDLQTKLSAMEKLQYALTTHELQVAQRMAEQQKIAAGQVQVTVRSSSSDTSPSDSNEARIQANKPETKEPRRHASLKPVSRKQPSPEPVIHSQQRSSSPYQEHALFTSSSEGQASLQEIWKLLDEEESFRSLSPVKERPSSQTPDHIPAREGSGESDGFTVKGKKAVPEKKGQKEKPRLSQKAQGKMRVIAQKPLVRNYNVQDDKQWKRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUQ8</accession>
    <name>A0A6P8HUQ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556342.1">
        <property type="nucleotide sequence ID" value="XM_031700482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUQ8"/>
    <dbReference type="GeneID" id="116293086"/>
    <dbReference type="KEGG" id="aten:116293086"/>
    <dbReference type="InParanoid" id="A0A6P8HUQ8"/>
    <dbReference type="OrthoDB" id="5970352at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="398"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="498"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556342.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="66512" checksum="10D3034C64FF19EF" modified="2020-12-02" version="1">MMGRFLTITFDNHSEFLTLCEVEVHTEDYTRLAIGISNSIAVPDNKMSASSNYSNTRAAAKARLLGNSSWRPRDDDTNPWLRIDLGEIYYVFAVATQGDPNNDERTVKYKVKGSIDNIKWVPVESKTLEKVFTGNENQATIIIKHSLPSPLAAKFVRFYPVGKIEAYALRVEIYGVTKEPAQPIPPPIGNKKLHPSNGSHADLVCRAEGGLSIKWYHNDTDITSYSNGTARTGSILISTVRVNYTSAEDVYDKYSCDKALRHCTSLDYICQVDYGSYRKLQSSGKISTLLVPTRPRHLNATINPQRGIQRPTVTLKWEKPMRAIGNITSYTLFYNYVIDKNSNMTSLTITDFTSMSYTVNVIGGAHFEFYLKANANGLIGDPSETWTANIQECKPSSAPANVKVIKIENGKYNVSWEEIPRELSNGKIIAYEINWSSLTRRMRRSPVVSRAANASESPYMLVSISLTDNMKYNLTVRGYTIGGPGPFSETIVLKIVDCRDLALGMQNRVMPADKITASSGTAGDQARLNYTNGTSWCAMGNDTSPYLQIDLGTPHIICAVSTQGDHQTKRWVKAFQLNCSDDGKTYHPYRENGKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HV05</accession>
    <name>A0A6P8HV05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116293169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116293169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031556427.1">
        <property type="nucleotide sequence ID" value="XM_031700567.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116293169"/>
    <dbReference type="InParanoid" id="A0A6P8HV05"/>
    <dbReference type="OrthoDB" id="5989083at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="901"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1608"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1644"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1675"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1720"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1763"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1812"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1836"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="592"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="1610"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="11">
        <location>
            <position position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556427.1"/>
        </source>
    </evidence>
    <sequence length="1902" mass="216940" checksum="B1A0A9CC8466CA21" modified="2020-12-02" version="1">MSQVRKTSKNLEKIPFQDKDDMFTTQDYLGIGSIKRKREKRHLQQDKEVNVKNFTHTSSYKETQSISSQNSTCLTNCTVIRQVIHYGRTECHCEVCCLKAFNECCVKQNLFGYGNYSMQISPMRCNCSQKLSKPWPNRPKNKFVRSECVNNYWMIASCLSSWPQDEILNKCITGPAGFPSKSTLRVSVPVFTPERKVFRNRYCALCNNETSFEPYKVVIQCETSPPASYSPQKAIEYLFSRCNEPKWEPQENQISQPCPRINLSCSEGEFGVRKENHPSRIPNDFNVTITSSDSNSYYSRCKEIKTADCSLKPRPNFKISGNGQFLNTVSLSFTLDVMNDAEKPVLVKISCPTKKPVYDPYLEECRHGLIPSPKNAPFDSYRIRLFIENFSGLTVLPTLEDFRAFFEKEFGFGVIQLRYFTQGFQFDIXIGKLSNYSAKSYKLKNYLNFTNQFNITIDNVQLSVYKVTYRILTCVNLEYYEKHEYAILHGYMPAVYLNNSREIIGYFNYYSGSNDTIRVCRLRLSNCSGVYTPLEKDEYTMLKNNSITVKGSGTIYNQQEYDIYNGTLWICVDFPRTFSAYQTPKKSKPLAFSVLTFVCMSLSIIGLVFVLVTYSLFSELRTPPGINLMNLSVSILLAQLLWLLGSGQTDTPMACTVIAILLHYLFLVSFVWTSIIAFDTWSAFSAENNAFRDSNREKCIKVLRHVAVGWLXALVYVGICVGLDFTDTVTIGYTSRIACWMANKWAILYFFAVPVFVFLVFNIMFCVMTFRAIKVTTAQARAAPDHEIKMNFGIYVCISSIMGFMWIFGFVAPFGWQFLWYPFVILNGLQGVYIALAFALNKRARGLCKRWFKGRSPPNETSNTSVSNTNIGVTEYNENKDSGVQKQRTEEGIASKSRMQGIRLAGLLLXFLLHIHQTDEKINEGTNTFFANEQLKKTTMEXTLENQDVSKNSREVQGEFFEAGAEYKGLTDIRNLRDEGHPKDKAFLPRYVDLWATKSKTTLNSKSNIFENIEDYPDNENGVSHPKSKNMKKDKKILETKKARSSRQRRTSQTPETTLVCEEELSCRNRCQNPRKGLYQTQLSCFCDXDCEFFLDCCADYHDFCGTNGLNMTNSTGHNTSLAENLVNQQNRDLWKCYHGDVVPGSIGAWMIGXCPSSWPEDDVLYRCRNISETDEITKDNYRYLPVYTNNGRVYHNRXCAECNGVXXXXXTEYALSIECDFTPPRHLSFESTLSYLFDYCSDIHWSPRKGDDPRRYCLIIVSPVSAANSVSTLDIDIKMTLAKCLTGKPGIVTRRYFYKNIDCAKSDLDNLNEISCGPNITASAYGIKLPGETSHLPNSLSVIFDFNNANSRGLDSMQIKTRCPSEQVYDHYLDICRDALPTLPSFSDVYEYQVVLWLEPGISKFEEDDFYRRVLSQALAVPIQHVQNIYVFQNISFTLQVRKNERLQPNAQNILEFTTPFNTTIHGLLRTVIKATKRILSCANRQKYDRSEYTVLQDDSSAVVIKKTGEVFQSTDYYLNTTEXSTSANDSQAIFVCRHHQISICSGVYILINEGEFRVLMNKSIFVNASKQVYDLSEYTWINKSVLVCENFSTIYYQSKVVPKDDAVLTTITIVCMSLSIIGLVFVLVTYSLFSELRTPPGINLMNLSVSILLAQLLWLLGSGQTDTTIPCTVIAVILHYLFLVSFVWTSIIAFDTWRAFSVENNAFSDSKRKKYVKILRHVAVGWLPALVYVGICVGLDFTDTVNIGYKSRIACWMANKWAILYFFAVPVFIFLVFNIMFCSMTFRAIKTTTAQAGAALDNNTKKNFGIYVRIASLMGFTWIFGFVAPFGWQFLWYPFVILNGLQGVYIALAFALNKRSRGLYKRILGSKSTPQQAASLSTISRLNTHDLSYNESDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVF3</accession>
    <name>A0A6P8HVF3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cathepsin B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116293307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556577.1">
        <property type="nucleotide sequence ID" value="XM_031700717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HVF3"/>
    <dbReference type="FunCoup" id="A0A6P8HVF3">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="GeneID" id="116293307"/>
    <dbReference type="KEGG" id="aten:116293307"/>
    <dbReference type="InParanoid" id="A0A6P8HVF3"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028214415" evidence="8">
        <location>
            <begin position="17"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="81"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031556577.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="36128" checksum="082E79F1C2AA04E4" modified="2020-12-02" version="1">MLSCLVLSLAIAVASAMPANINPLSQEAIDYINSLEEMTWKAGKNFDDSVYTIDDIKAMCGALKSPVPLLKIRESLGAMEIPDNFDSREEWSNCASIKEVRDQGSCGSCWAFGAVEAMTDRFCIHSKNKDTPHISAEDLLTCCDSCGAGCNGGYPEAAWQYWKNDGIVTGGQYGSHEGCQPYLIAKCDHHVVGKLLPCKGIQPTPECKHKCEAGYNVSYSDDKRHGMSAYSVGSDPSEIQKEIMTNGPVEGAFTVYADFPTYKSGVYQHKSGGELGGHAIKILGWGVENGTPYWLVANSWNPDWGDKGFFKILRGSDECGIESGIVGGMPKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWR6</accession>
    <name>A0A6P8HWR6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipase A and acyltransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116293778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557105.1">
        <property type="nucleotide sequence ID" value="XM_031701245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWR6"/>
    <dbReference type="FunCoup" id="A0A6P8HWR6">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="GeneID" id="116293778"/>
    <dbReference type="KEGG" id="aten:116293778"/>
    <dbReference type="InParanoid" id="A0A6P8HWR6"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031557105.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19837" checksum="15129F96ED994751" modified="2020-12-02" version="1">MDAYYCPGNTGDLLVFKRSIYKHYAVNIGDGEIVHLTSDLDNDLTGFVRGLSIDCCSSTQEGNAVVKREPYILFKKSGDRVTVEDDWKGKTALQRFEIVRRALSRVGRRGYNLLFKNCEHFARWCRYGEETSDQAINFGIGLGVAAGAVLLGLGLGAYCLSSDSEAEKKRKQRNRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX07</accession>
    <name>A0A6P8HX07_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559923.1">
        <property type="nucleotide sequence ID" value="XM_031704063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HX07"/>
    <dbReference type="GeneID" id="116296106"/>
    <dbReference type="KEGG" id="aten:116296106"/>
    <dbReference type="InParanoid" id="A0A6P8HX07"/>
    <dbReference type="OrthoDB" id="10281442at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031559923.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="31879" checksum="65B5C35370458E39" modified="2020-12-02" version="1">MARRRLFSLFYISSLWIFLSVITYMTQREYPYNKEPLSYADLFRCDLHQCTDSRHSSSSCLSQARLVLTRLLRQFSLAASKTNLIYFLYKKSLLAAARCKGHVPADFPNIEIAVFQNDIQKLLKVPLQVNNTVLELTPEKKKHPNSIIRAKLIDTKSCLLRTQENGLFMDIAVLKKDTKGSILDSYTSKLPWLRNLKGPHYYSERDIFPLRTLKFDGFSFAVPRSWEKLLTSWYGKNWGKSISLMDYEVSYNPTEAVDPIHSCKERTSHTLIECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXF2</accession>
    <name>A0A6P8HXF2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein LOC116296230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116296230</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Plastid</location>
            <location evidence="17">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560083.1">
        <property type="nucleotide sequence ID" value="XM_031704223.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116296230"/>
    <dbReference type="InParanoid" id="A0A6P8HXF2"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF135">
        <property type="entry name" value="TRANSLOCASE OF CHLOROPLAST 120, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AIG1-type G" evidence="18">
        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="20">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="20">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031560083.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32501" checksum="6A8EF46354AE83C7" modified="2020-12-02" version="1">MAAGSTSTDSMETEHLLDKNKDRXFXXXLVXGKTGVGKFRLENALVDRNITKXDACKSTPYETTIENVAVKVWDSPGLQDGTSNEDQYIQDMXXDIXDIALMIYCVRMDEXRFYDADKKAIRILTEEFGKXXWKHAVVALTFANKVEDPDGEDXLXYFXSQLEEWKKQFKEYFASVGXDPXVCXPVIPXGNKLKSMRLPDRENWLSDLWIECRRVMKPSSSTLXMYRIDSQRLVKALESRTTLDAGAYESQHQASQSQRTQPLAVVKYLIDKLWEYFGGQYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZV0</accession>
    <name>A0A6P8HZV0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RWD domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116297750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561894.1">
        <property type="nucleotide sequence ID" value="XM_031706034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZV0"/>
    <dbReference type="FunCoup" id="A0A6P8HZV0">
        <property type="interactions" value="955"/>
    </dbReference>
    <dbReference type="GeneID" id="116297750"/>
    <dbReference type="KEGG" id="aten:116297750"/>
    <dbReference type="InParanoid" id="A0A6P8HZV0"/>
    <dbReference type="OrthoDB" id="10045773at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23817">
        <property type="entry name" value="RWD-RWDD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042770">
        <property type="entry name" value="RWDD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275:SF1">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561894.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="22082" checksum="C645A87A18EB5570" modified="2020-12-02" version="1">MDCKVEQEEEREVLRSIYEEDERFKEINPTTFQYKFGEDGHFKSFVLEISWTDNYPENAPNINMDAFYNKHLLDKVKGNIISRLSEQCDLNLGCAMTYSLFDWTNEHCEELTEEQDEAQQPLEAPESSIEEKDNQDNEQKAEKTEKKEKLTKNQKRKLGNRLNAKGELERGWNWVDIVKHLSKTKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0M9</accession>
    <name>A0A6P8I0M9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="6">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116294888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="6"/>
    <dbReference type="RefSeq" id="XP_031558435.1">
        <property type="nucleotide sequence ID" value="XM_031702575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0M9"/>
    <dbReference type="FunCoup" id="A0A6P8I0M9">
        <property type="interactions" value="1791"/>
    </dbReference>
    <dbReference type="GeneID" id="116294888"/>
    <dbReference type="KEGG" id="aten:116294888"/>
    <dbReference type="InParanoid" id="A0A6P8I0M9"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000079">
        <property type="entry name" value="Enolase-phosphatase E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01681">
        <property type="entry name" value="Salvage_MtnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00044">
        <property type="entry name" value="enolase-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558435.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33314" checksum="BF9F13BA5E633D21" modified="2020-12-02" version="1">MAVELDAENEKVLKRRDIRRSFRVVLLDIEGTTTPITFVKDTLFPYVRKNVQNYLKKNWITTECQQDIKALQEQAEKDKDLDGMVPILKYDKDDENIDETTKEKVIRSIVDNVLWQMDSDRKITALKQLQGHIWKKAYEDGEIKGEVYDDVVPALEEWTSSRIKVYIYSSGSVEAQKLLFKYSDKGDLLKYFSGHFDTKIGLKVECESYKKIVECVGEKPGEILFITDVVKEACAATEAGMQTVLSVRPGNTPLTDDDKSTYKTIKSFSNLTEEQDLQNGKPKKARTDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0T6</accession>
    <name>A0A6P8I0T6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116297119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116297119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031561141.1">
        <property type="nucleotide sequence ID" value="XM_031705281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0T6"/>
    <dbReference type="GeneID" id="116297119"/>
    <dbReference type="KEGG" id="aten:116297119"/>
    <dbReference type="InParanoid" id="A0A6P8I0T6"/>
    <dbReference type="OrthoDB" id="5981025at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042655">
        <property type="entry name" value="LRC72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46759:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46759">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="830"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031561141.1"/>
        </source>
    </evidence>
    <sequence length="861" mass="99012" checksum="09499DE5891ADDD8" modified="2020-12-02" version="1">MRISNQLLRSRAARPLYSTELIDLSHLELVSVDRLELCPKLQTLILRQNRIEAVPNLDCCPQLWKIDLANNKLRSLEGLSRFPVFGTLILSNNELDWNELLKIRHIHILDLTLHGNPLLEMDSYYRLHVIDSLPNIWMLDGRIITTAERAQVSQFFKDTALCDRPVRHKLPRNQFIPSSLKNIKVTGIHGTMTDHYMRHFPHRSTLNIDLDRRRLHYLAYNLQRDVNLDLKYTTREKVKPTSVIENLISCRKNDQERCNMLLLLLVGSLEFSIPLSLVQQTLEITRLKNIDNVNTMDLFMFSRETRCRVASLFLSAVKIERDQNIEGGLYNRLYLSLYDLVSDLVRLANGDDIARYQAVRKRFDTRKSGYRCLLASEIVQLLCIVPVFFDFIGKDPGVMDLISVATKNPDIGEQIKTISWKVQAEGGDTNKVYQEISQFLLKKTKEASSSIPNPGRGKVLDVFEKNNYPFYRMEPSYIITSKRLIVKPANQDKPQPSSKLRVRPSTGASTSPTRSARTSPARPKTGIRKPRLGDRVQLGHQACGRLVALPENHVGLVQIDTKAASRFQQADYSLHSKFDDQFYYVNFRHMEWDPKVAQWRFASGFSELSLNAGNRRTTETNEEETRFLSEILQQSLKLRADLPFTQKETPEEQDDKREGHVLITDHVRSIVRECLQEAEVEWPDEEKPLNPEATEIEQTWTEPERVESPVSQSEVTVHVDSDSFTASHDLQVVDEESAEPSEVQEHWNVNERIDAPIPRSTPYKTFMRVSHLINVDMYQPNERYHHLHPSREGDVDRDPVGCSVHEEEMVSSTENARLEAWKSYELIKRDSSSGFPSRVGSATSKHTPPQRPSTPLHSNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0V3</accession>
    <name>A0A6P8I0V3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561161.1">
        <property type="nucleotide sequence ID" value="XM_031705301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0V3"/>
    <dbReference type="GeneID" id="116297137"/>
    <dbReference type="KEGG" id="aten:116297137"/>
    <dbReference type="InParanoid" id="A0A6P8I0V3"/>
    <dbReference type="OrthoDB" id="408760at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561161.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25173" checksum="3DED385644A884CF" modified="2020-12-02" version="1">MFARSKLVRILAFGDSLTQGHTYQLTHFHPYTHRLRQLLQEHKSVKFDVDNAGITGEFVRDQMTKRLPLLLRKNGPYNLIIILGGTNDLGDFNPGEEKALFKEIVSLHDIAHEHGAKTLLLTIPESDYIFKDMGANGTSYIKEDGEKGRILINGMLRDFAKENDDVTLCDLDQEHRHTNLKEEEKVKYWDDGLHYTPEGYDRMGEIIFEKIKHLYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1K8</accession>
    <name>A0A6P8I1K8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0600 protein C5orf51 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562424.1">
        <property type="nucleotide sequence ID" value="XM_031706564.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I1K8">
        <property type="interactions" value="2234"/>
    </dbReference>
    <dbReference type="GeneID" id="116298184"/>
    <dbReference type="KEGG" id="aten:116298184"/>
    <dbReference type="InParanoid" id="A0A6P8I1K8"/>
    <dbReference type="OrthoDB" id="6135810at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037657">
        <property type="entry name" value="RIMC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28494:SF1">
        <property type="entry name" value="RAB7A-INTERACTING MON1-CCZ1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28494">
        <property type="entry name" value="UPF0600 PROTEIN C5ORF51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17716">
        <property type="entry name" value="RIMC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031562424.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31654" checksum="75A33A4F4CB6EAAC" modified="2020-12-02" version="1">MYSFAMQQTSQEKLNQNTLANLLVEYSKSVMDKTYVEECRLVNDEFKDNDSKQKLLNIIDKGCYLNPKTSSSFIRGFFSMPEQLSIPEDIAKQFLPSLENDVKTEELLGKDVMECLYWRKGALLYMYCNTIYSDNERWTGMMADFXKDCEVGVEFLQKMLIVRTPSEEDKESMESRHDSTMELLKQGIFSDTHLLGLMYAGELCYWHWKTQNLNKNMATSGDTTRPFNSLAEGKRFLGRYIRTVRGPLKGMGWDTIKAEQYLDELNNVQEVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I201</accession>
    <name>A0A6P8I201_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TATA-box-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116297450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561566.1">
        <property type="nucleotide sequence ID" value="XM_031705706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I201"/>
    <dbReference type="FunCoup" id="A0A6P8I201">
        <property type="interactions" value="2705"/>
    </dbReference>
    <dbReference type="GeneID" id="116297450"/>
    <dbReference type="KEGG" id="aten:116297450"/>
    <dbReference type="InParanoid" id="A0A6P8I201"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031561566.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26793" checksum="B31553740AD7778B" modified="2020-12-02" version="1">MSQEDENRYGAGSSLQAHAGIMTPSPGMSTTTGLPGGLAAYPHTPSPMPPLTPMTPMTPMTAEQSGIIPQLQNIVSTVNLGCKLDLKKIALHARNAEYNPKRFAAVIMRIRDPRTTALIFSSGKMVCTGAKSEEQSKLAARKYARVVQKLGFPAKFTEFKIQNMVGSCDVKFPIRLEGLVLAHGQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRSEIYEAFDNIYPILKTFRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I292</accession>
    <name>A0A6P8I292_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297545</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561651.1">
        <property type="nucleotide sequence ID" value="XM_031705791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I292"/>
    <dbReference type="GeneID" id="116297545"/>
    <dbReference type="KEGG" id="aten:116297545"/>
    <dbReference type="InParanoid" id="A0A6P8I292"/>
    <dbReference type="OrthoDB" id="5974595at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561651.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19312" checksum="12AE9E12AB8B730C" modified="2020-12-02" version="1">FAEKGLETLQKSAEVALNRYEEKDHDLCSKLQKNRSEQDELRKRLAALQVQEAALEDERDEKKATQQRAEQTEKRARDELQNWKRQIEELHRCCQAALSVMWQFKEGSFKLINSSIVNKTNEERHLHELDILAHKTLREALVAASLDCKEVIKSSDASLELITKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I2Z6</accession>
    <name>A0A6P8I2Z6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Centromere/kinetochore protein zw10 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116298002</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZW10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562203.1">
        <property type="nucleotide sequence ID" value="XM_031706343.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I2Z6">
        <property type="interactions" value="3093"/>
    </dbReference>
    <dbReference type="GeneID" id="116298002"/>
    <dbReference type="KEGG" id="aten:116298002"/>
    <dbReference type="InParanoid" id="A0A6P8I2Z6"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009361">
        <property type="entry name" value="Zw10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06248">
        <property type="entry name" value="Zw10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="12">
        <location>
            <begin position="189"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="13">
        <location>
            <begin position="475"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="14">
        <location>
            <begin position="627"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031562203.1"/>
        </source>
    </evidence>
    <sequence length="783" mass="88378" checksum="3C4E9EFCB100253D" modified="2020-12-02" version="1">MADVASSKKTIQSSLVTDVLQKAGHLEQEDFHVCVKQMLQKAEEIKVDVFQAIYKEYSFGAFQDLNSSTYELDWRVKNLLTDIENASKRIKGSIHPQLDLAATEHSKLTQEFHETEAIADVLTRLCKIHTALDRFPTEMDTEEYCKAAEIFDTVNEDLSQLPKAGQESKIFTALREELRRQHSELINKLESVWSKSITWNTPTTASLDSIHAHLKTKLTFTTVESGMENVINAMQALNVLDKRIKIFGKKLLQFFFRPMIVFPNLKPSIEKTKQSVVVSLVKDPTRQKVLDPGKVYIKITEVLDVIKNHFHPNEEEKSEKPGDNNEKNVQLFSLLGSVLWPVLSEDIIKDCLAKSIPNTSAQLEKYQEVIANTEDFESKLKLLGFLQETPSALTKYIKDISVHVGNKKCQERLVAARDLMKDNIHNTIAIDKYSDTAVLRSLGEIENAVNGKNGKKESSLSIKNEANNQLSPFTFQLPSCRISESTKELMNLAYKTLLEATKSTPQSAIQLFYTVRNMFELFCNVVPTYHKESLTNLPQLAALHHNNCMYISHLLLTMGHQFKSQLPEPLNQGAATFMDLVPTIRSLGENCLLEQLRRQRSQLLNIIRDVGGLADAHEDARGEKIERAIKQVLHQLLHLXKMWLGILPLNLFHQSLGALLDAVLIDIIDKVLQLEDISSDEATRLHSILSILINRGPELFMEPTKDKDQSQVDPLMVVPHWSKYKQVVGALEASLQDLADGWSDGKGPLALDLTANEVRGLIRALFQNTDRRAAVLAKIKAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I368</accession>
    <name>A0A6P8I368_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116298612</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562989.1">
        <property type="nucleotide sequence ID" value="XM_031707129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I368"/>
    <dbReference type="GeneID" id="116298612"/>
    <dbReference type="KEGG" id="aten:116298612"/>
    <dbReference type="InParanoid" id="A0A6P8I368"/>
    <dbReference type="OrthoDB" id="5990559at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562989.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35237" checksum="15B96EEDD57B8A96" modified="2020-12-02" version="1">MGCGTSQVKKTERSNSQVTIESQQRTVAAYRRQRIARDMEQVASLRAEAEVEKALMLKRSSLGSVDDRRPSYVMRVLEDLAEVEEGQEEVEERCADPVIPNGTYHNEKLAELEHNMNKRNTALHSSVTQRHSATPENELEDDLLLNTRAQNNELVEDKQNENDTDIVLHTSVTQENSVTPKEELPGNLELTTRAQNDNENALDSAEAKDGLSKTIETKEESYLDVTTCTQNDEQNSNPISDLETIREEEREGFGSKDQRGSIFHSTTHAHENTAKTNHNLTHHEKEEGDTRKEDDMENKLVLTAENDNPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I465</accession>
    <name>A0A6P8I465_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116298050 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562251.1">
        <property type="nucleotide sequence ID" value="XM_031706391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I465"/>
    <dbReference type="GeneID" id="116298050"/>
    <dbReference type="KEGG" id="aten:116298050"/>
    <dbReference type="InParanoid" id="A0A6P8I465"/>
    <dbReference type="OrthoDB" id="10285524at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031562251.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="88747" checksum="EA7A7524407BDD23" modified="2020-12-02" version="1">MTKNSIRIIVCVALVVAGIACIISGIILLHEKSVASCHKDHYSPKASSILPVTCNYSQEALRVGLPEFLQKVQDTFYDLHPEKIYLKPNVLKKEILEKFQGYDPSPAKIKLTTDKSFELLAEIKGKKITKQLLKPRERKALSQVMHYLQHVFGMPYDGNYYTGYYLLGPGFFCVEMQSICTFTRLFSHWIVPPSSVNEVQILLNKIKTLNHTFSQYRQNLIDGVRAGMVRDIDDCKRGLHSFFVFYRNMNKVEDVMRQRIAKGLTRDSTLDKLSKEEKEKWFTKYNKTVKQDIRDHVLKYIGEPLYKLITYLKTTYLEHCLPVNESSGLSGLPLTHVYINGSKTNQLTYPYLPTGQRLNGSKAYESIMPYFTTSDITPNEVHDLGLKMINKLYAQVLELARNETHTSNTTQAKEMFARKLNDSSMFYGADLIPEIESNATAHERCTSSSSAKTYCPVRYKAMQRLVKDLYKVMSLMDSKTVEMFYFTGSKHTTPNCPVDVIIQYSPQFLIEQYHGIYPDCHSSSRVSIPFHVRRLGPKYGKWTMIGHEARPGHHTQTQGLLEHFRDLCGGVIGWLDTMTRYTAFNEGWAVYAEYPLIPVDMEMYANKPMYKYGMLRGQLWRAIRLVVDTGLHYKGFSHQKALQYFQEYMWETSDVMQQEVMRYQSVPGQATAYMVGQQHIIKLREHAQKELGKSFNLKDFHYHILKHGSTPLSYLTESIDEYIRCTKNIKDVGCEYVLTREGLGKPEGSDYITNIDVDSNFIHMTESYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4I8</accession>
    <name>A0A6P8I4I8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CX3C chemokine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559705.1">
        <property type="nucleotide sequence ID" value="XM_031703845.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4I8">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116295887"/>
    <dbReference type="InParanoid" id="A0A6P8I4I8"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="299"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="14">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031559705.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="70895" checksum="7ED4881F7549A1CF" modified="2020-12-02" version="1">MSYKVTMVFIKPLYLIFNAIILVVLMINVTKGNAVQNCSNISANSCPAVVKPRINCNCLFDSKCYLMVKCRLKKISDLEDSYDNILVYSLDLSRNSLKALQDKSFTGFEAVSVLKLSYNNIKYIQKGVFQGLNSLTILDLSFNQLHKWDSIDIAKQLPSLTELDVTGNTRWMPTRHVTSLPSITAIKGVVSHTIRYTDDCVFCDLLRPKTRECTLNETSVQQECLKITFYFNDNFSDWGLKNFTMKCRKDSHENRICKDQHLPTIKNTRYSISTADMCWSSIIKWTTMNIPISLFAIIINAVVIVTIFSSRILKKNVTLFLVGNIALGDFCQGLYLFILTLTRRTMSSFQFYEFKNPYFCFLLIVLYLSAHXLSVLVCFLVAVERYLCVVYSTKPSVHIXSRAAKMLLAIVWLLISGAIAFPYILHTKISXFTDYTCVFIEFEVRRNTKHNFVGYLGAVGIILYAISFALYSHVFYTVRKSSTNMGIQREGRLAKKIMIMIATNLFFFLTPVIVSYTEESGFTNFLKKDIINLYVYLNTFAFLCFVLNSCLNPFLYAFWXEKFISELKRMLGVRLINVVAVGDTPKDHHSRNTNDVQKFSQYQLQFKKAKLIEVGPSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I5H3</accession>
    <name>A0A6P8I5H3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Rhodopsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC116298770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563178.1">
        <property type="nucleotide sequence ID" value="XM_031707318.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031563179.1">
        <property type="nucleotide sequence ID" value="XM_031707319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298770"/>
    <dbReference type="KEGG" id="aten:116298770"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14969">
        <property type="entry name" value="7tmA_Opsins_type2_animals"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000219">
        <property type="entry name" value="Opsin 5-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031563178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563179.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40717" checksum="3686B75D3DA23212" modified="2020-12-02" version="1">MEIKLLEVHXYQPIAAIYCVILLLSFILNTSVIVIFLNNQSLLTXANLLLLSMAISDWLMAVLANTVGAYANASYWWTLNGAICQYFGFISSLCGLNSIVHLTALSVERWITVXMAINQELSKRKMTLVIAGLWLFSFIWCLFPLIGWSSYGPEPGFAGCSITWYSSKPSDKAYIVCLFIFFFFLPIIIMTFCYIGVFIEVKKMTKDAAARWGHEALPTQQTIRAQTKTIRMSVVMVFAYLIAWTPYAIVSLYSSFIASDITPLLSIMPAFFAKLSSCYNPIIYFFMYSKFRKAAKRLVIRHLVAPENSSAQAVSNTFASSFPRPIQFLRLKSTVVTQASGIPKAXSAIDASNVKKDIASESAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6E5</accession>
    <name>A0A6P8I6E5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116296676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116296676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560592.1">
        <property type="nucleotide sequence ID" value="XM_031704732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296676"/>
    <dbReference type="KEGG" id="aten:116296676"/>
    <dbReference type="InParanoid" id="A0A6P8I6E5"/>
    <dbReference type="OrthoDB" id="5949962at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031560592.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44788" checksum="FCF0D3731C46E533" modified="2020-12-02" version="1">MQVGEWLGFVINTIAMKFFLPEKKVSKLKGLLDSAISDGXCTYRFLAKIAGSVISSALAVGPVARLLTRQMYLTIEARSSWDSIVYFTPALLEELKFWYTNIDCFNGYRISSPPASCTVLFSDASELAFGGYAATLDGASVSGMWTDEEIGRSSTYRELKAIYYICFSYVEQLKHKKVKIFTDNQAAARIVSIGSSKLELQQIALSIFSLCFESDICLEAEWIPRERNQQADMLSRFIDRDDWSVNHSVFRTLDAMWGPHSCDRFASYYNAQISAYNSRFASPGSLGVDAFAQDWSKGINWLCPPVHLIVPVVRKLQNCHGCGTLIIPEWPSSMFWPYLHLSAFQFKPYVKEVFRLLRLANLLIEGPGQRAIYKTKKSVFLGCPAFDMLALRLDFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6Z2</accession>
    <name>A0A6P8I6Z2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centromere protein P-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116299748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564329.1">
        <property type="nucleotide sequence ID" value="XM_031708469.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A6P8I6Z2">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="GeneID" id="116299748"/>
    <dbReference type="KEGG" id="aten:116299748"/>
    <dbReference type="InParanoid" id="A0A6P8I6Z2"/>
    <dbReference type="OrthoDB" id="5976950at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027801">
        <property type="entry name" value="CENP-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28577">
        <property type="entry name" value="CENTROMERE PROTEIN P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28577:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13096">
        <property type="entry name" value="CENP-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564329.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36429" checksum="4CBF9EE57AFF8499" modified="2020-12-02" version="1">MPKRKRKENPDLKATCLKEIEELSKEINCLENDLEIKERHVAEVFADESLAGIINSLRVGHRNPRKKSNEEQELNLLLSKLEKLESLTGIIFDENKAELISSTDDYINNNIKIARTAKRWRRILSGKCFSLPFLIQFETEEIPEEEEPANVKKAVEDHEDITVRVTKLSFEVNCPLAAKELNRFIATAEQEKAIGTTFIALEQYAKWYDCRKKTFVHFKSKYPDLVCIFDGPNRSDTMEIRNRVHIGLYFIIHWTIIIQKDGNVLPQIDAFVACPSKVCGSEIMPVLNSTPEQFRKMLSRFGIEQAIECIIMIAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7I7</accession>
    <name>A0A6P8I7I7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC116297029</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116297029</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561016.1">
        <property type="nucleotide sequence ID" value="XM_031705156.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561017.1">
        <property type="nucleotide sequence ID" value="XM_031705157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7I7"/>
    <dbReference type="GeneID" id="116297029"/>
    <dbReference type="KEGG" id="aten:116297029"/>
    <dbReference type="OrthoDB" id="5960751at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031561017.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55286" checksum="EDEFD3E74B8C3EB2" modified="2020-12-02" version="1">MRISGTSRDHHIACYRPVRVVFLLVLSVLLYFIFKEYLHNHKANVTKPVVDTAELGCFYTVTPPVNPIAWQEIVILIIPSPGGLCKSYNQQRNITVGASTFRVQAFGSQEMVIGQAVHLGNDTYQAKLRVSFEGDYVVMVILTFTDNAHLEYRFHSNAILQHVFNSPFEMRVSAGPSPAGYTRYCTQEESGTAPGRWVECGKLAGIEDCGSWQLNSVYDFDQIHGFHWVPYSCQLHQYSNDEIKKCFAQNGWSSIAFTGDSHMRYRTYHWVTRLYGGCRGCIKTYIKMVFDKIPRMEWIFDARGTRWPMTFPEISFPNEVYVHPKTRRSMFSKELPSSVFDVNLFILNFGHWILRESTQEEFMEEKLRAYVEAIQKMNATGGRKKFLWVNTVSLPWRDDKAVVEWIENPSPSRVAQWNRLSDSFMRAHGIQIIDAFQISNSRIGATHDQTHYAKRLKNGDCGGVVENAISNTIANALCNYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7J3</accession>
    <name>A0A6P8I7J3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116299444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563963.1">
        <property type="nucleotide sequence ID" value="XM_031708103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299444"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="111"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563963.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36964" checksum="A34A27A59E3A6A37" modified="2020-12-02" version="1">MPLIGTRLTHQGLSDTASNIILQAWRTGTQKQYKSYLSRWEQYCSEQQIDPISSSVTNGINFLGELYEKGLSYSAINTARSALSTVISPPEGCTFGDHPLVTKFLKGVYNIRPSFQRYKEIWDVSTVLKYLKTLSPPHLLNLKDLTLKITMLIALLSGQRCQTLHALNISQMTLSGTTCIFHIRELLKTSKPGKHFGRLELKAFDEDNQLCVITFLREYVERTKLLRGAXDQLLISYCKPFKPVSSETISRWLREVLKNSGIDTSKFSGHSTRSASTSAATAANVSIHTIMEAAGWSNAETFRKFYCKPVTSRKSDNFGDNLLKSVNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I800</accession>
    <name>A0A6P8I800_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A disintegrin and metalloproteinase with thrombospondin motifs 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116298942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031563386.1">
        <property type="nucleotide sequence ID" value="XM_031707526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I800"/>
    <dbReference type="GeneID" id="116298942"/>
    <dbReference type="KEGG" id="aten:116298942"/>
    <dbReference type="InParanoid" id="A0A6P8I800"/>
    <dbReference type="OrthoDB" id="10386314at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031563386.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20336" checksum="F2193C166F7328E2" modified="2020-12-02" version="1">MCSHRCGNGNRTRRVPCVQQVAQFTYSEVESRHCNASIRPHRSEPCNQIACGAAWAVDHWSECVLVNGSLIATRTVRCQNILGNGTVINADPKECTEVDNIILKSVKNCTFTTTSTSPTTAKGPDVETSIGIWLPITVVASIIAAFLIFLFIFILYRTGYLACHYKRGKASFEGLKLEHAESVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8N3</accession>
    <name>A0A6P8I8N3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116299842</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564418.1">
        <property type="nucleotide sequence ID" value="XM_031708558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8N3"/>
    <dbReference type="GeneID" id="116299842"/>
    <dbReference type="KEGG" id="aten:116299842"/>
    <dbReference type="InParanoid" id="A0A6P8I8N3"/>
    <dbReference type="OrthoDB" id="10003276at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="169"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="412"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564418.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="65172" checksum="31E354D2519A3B2B" modified="2020-12-02" version="1">MQNLDLFVGGVDSGDTSYLKDYYAIGTGEPPEDSQQDYTLISASESNGVTMVHCKRRLNTQDVKDLLIQPGDPVYIAWAYHTSSDDLQYHSNHRGYSSQMHVLVPVVTTAYKHEIYLRHDRARARTGSISFLERTAKMKSFNFFALVFRIFVLFFATADALNHLTLGNGIFNVTWNYLSASQEIEFEVRAKTTGYVSLGLTKTNSGMQNLDLFVGGVDSGGTSYLKDNYAIGKGEPPQDSQQDYTLISASESNGVTMVHCKRRLNTQDVKDLLIQPGDKVYFAWATHTSSDTLAYHTARGYSPQVHELVPLPQTTTPPPTTAPTTAPITAPTTAPTTAPITAPATAPTTAPTTAPVTAPTTAPTTAPITAPATAPTTAPTTAPANATNTAPNTSPTIAPSNVYNKQLSFNNGDYLVFWKFDSNTNELFFKLVVKATGWVGLGFSQQNSGMANLDIVVANVSAGQGFIGDYYARGTFTPSRDSSQDWHLISAKEDGVNTTVEFKRKLDTEDANDQQFKTGESYFLAWAYHSSSDDFTQHTQRGYSQNVDLVVAADAGSTTTARPSPETTSTQKPIPTTAATVTQCSLLLMMISFLASFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAY0</accession>
    <name>A0A6P8IAY0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Glutamate receptor ionotropic, kainate 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116298197</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031562437.1">
        <property type="nucleotide sequence ID" value="XM_031706577.1"/>
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    <dbReference type="FunCoup" id="A0A6P8IAY0">
        <property type="interactions" value="1038"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116298197"/>
    <dbReference type="InParanoid" id="A0A6P8IAY0"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13685">
        <property type="entry name" value="PBP2_iGluR_non_NMDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028395814" evidence="20">
        <location>
            <begin position="24"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="21">
        <location>
            <begin position="449"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="22">
        <location>
            <begin position="459"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="770"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="24">
        <location>
            <position position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031562437.1"/>
        </source>
    </evidence>
    <sequence length="959" mass="108148" checksum="F1D1991518D8A15F" modified="2020-12-02" version="1">MDKRFLVCILVLSSVLQIQFCSSQEVEIRVGALLGFNANTSQKSPEEIAFYLAIEWINQNDFLPTGKRLRGFVEKVDPNDDYDCIYHADKLLSLGVVALIGPLASTPIPVIGPLTSVAHVPQILPLTSWDTSDLDVDGYEYLLRMSPTEKLKAQAMIDIVKHYKWKQVAVLSLRGDEYPEYNQGQNAFRILASENEIDVLFDRLIPPNPRDSTKINPKDEMYGLTQSDLRVAIVFCPAWSVKELLYVANKYKLIEEWAWIFSDLGSSDVELTGSTGAVPTYMRGVIGMRASIGKGAAFNDLKDNFHKKIDKLNITTDITAAAGHVYDSVLITAKGIQDTLNQGIQLSSSQIPKGLCHNENEPRKGGRELFQXIKKTTIQGAMSDLGFEETGEPRCASFDIVNLRKSGSVKLAEWDTANKLRQINGTRAVWMSGKTKVPFDIPNLLKNKTINVVAVLAPPFVMKKSSSDNKTAEYEGLSIDLLEYMRKELGFRYKISLAPDGVFGSKDRLTGKWNGVMREIIDGKAKLSIAPLTINSDGQNVVDFTHPYMTFGIAFIMRVNEVEENYFRFLKPYHTNLWIAICGMVLTMGIFLWNFSILSPFGYYGRYSQHPNKLKVKPKIKATKNTLSFVNAIWSSWLCYLSQGGQHPASLSGKIAVSVFWFAILIMNATYTANLAAYLTVSRMQTPIETVEDLALQTKIQYGTLVNSQLQKFFLDTDVPRFLVMGQFMEQRKTWMPTIQAAIDRVMNSNFAFIADRPILEYIARQKEYCGKLKVIGGFGTTYGYGFALPLNSPTTNLFNMEIFRLQRDMIMDSLKHKWSSKETCKMIDNMNIKSQNAKGESAFIQRIGLYDMLGVFIFMGIGIALGFIFMIIEWVYACIRDVATKQGPKGYLEAFSLRLNRVCTDIFVKKQEPEEEXTSAEVIQPPKMPKQWTRMTKRLNPKNGEPSTYDIQSYEATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICU3</accession>
    <name>A0A6P8ICU3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116298547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
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            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562950.1">
        <property type="nucleotide sequence ID" value="XM_031707090.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298547"/>
    <dbReference type="KEGG" id="aten:116298547"/>
    <dbReference type="InParanoid" id="A0A6P8ICU3"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027969064" evidence="1">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562950.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31062" checksum="27CAE0396982BF9A" modified="2020-12-02" version="1">MIFLMVTRLLVFWFIXGSYCRVSQNKDYLAANLDDYYSSIIKIPPPRETAVKFAKYFLGREIDINKHARRPRSDDFLQRKQTDTVLIIDSSESVKRVNFKLGLRALQAMVERGKPDTKYAAITFSNHAKLEFVFVDKENAKKNLKKIEYRRGKTNTQEALMMALNKLIKSNTSNIRVGSVRRIFLVTDGLSNVKRHMTLMRGQQLKFAGVEIFVMAVGQYDQGLEEIVGLVSSTLAHLYRVANMKGFLRVIKLIPKNVEKNWLSGMNVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID17</accession>
    <name>A0A6P8ID17_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ultraviolet-B receptor UVR8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116299339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563842.1">
        <property type="nucleotide sequence ID" value="XM_031707982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID17"/>
    <dbReference type="GeneID" id="116299339"/>
    <dbReference type="KEGG" id="aten:116299339"/>
    <dbReference type="InParanoid" id="A0A6P8ID17"/>
    <dbReference type="OrthoDB" id="10253607at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF388">
        <property type="entry name" value="CLARET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="291"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="342"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="394"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="449"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="507"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="563"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031563842.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="68850" checksum="7EAE33C56C7C48EC" modified="2020-12-02" version="1">MLQLHVRLTEPPDSSSCPENMAPLNTPEVIQAIREMNKGVTMLKAGRRGSPHFRKFKLSEDLTYLQWESRRKGKESVVYISQMIELIKGQKTKVFESCQIPQYECLSFSVVYKISNGSTKTLDIVCKSKVEFEAWTTGLQALQSGFNDKEAVDSKLDTEEVTDQTDNVKVEFSRLGLETVKYKEDACDVYTWGSGTKGMLGHGEDTEESYPRVVEALLGKDIRKVACGTSHTIALSKEGEVFSWGSGYGGRLGQGHLRDRFTPIRIAALKGKNVTEVSCNEFHSAAICGNEDLLTWGKNGPRLGYECSSKETSPRLVKGLDDVKVTHVTCGLKHTLVCTKQGTVFSFGDNEHGQLGVSDIQSTTTPICVSAFSGHTIVQVSCGRYHSAALADFGALWLWGWNEYGQLGNGTFTNTSKPTLMGSINDIRQEAISDVSCGAHHTVFLTKKGKTFSFGDNSDGQLGIRLDSKLEGQTKFSFAIRARIPTDSKPLHVACGDYHTALVTDGGELFTWGRGQGGRLGHGDDKNRPLPSAVEAMEGKHVRFVACGSEHTACTVTRAWVPDEEVKTCMACKIKFTTVRRRHHCRKCGGVFCGQCTPKRIPILSLGYSNPVRVCDKCYTILAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID26</accession>
    <name>A0A6P8ID26_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116298765</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116298765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563170.1">
        <property type="nucleotide sequence ID" value="XM_031707310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ID26"/>
    <dbReference type="GeneID" id="116298765"/>
    <dbReference type="KEGG" id="aten:116298765"/>
    <dbReference type="InParanoid" id="A0A6P8ID26"/>
    <dbReference type="OrthoDB" id="381520at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="194"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="729"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="772"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="856"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="940"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563170.1"/>
        </source>
    </evidence>
    <sequence length="1127" mass="126976" checksum="D660CD66BBA45E1F" modified="2020-12-02" version="1">MAKSQRFNSEEETNFLKGGLLVANIIPNGVREFLQQHFIKASKYNENNDLTSEAMEFLENISDHNFQELCTVAGQITMDDDANTGINHLINAREEFFKNVRKDHLSNHELENLLQEVHKGYTNLSLPLDVLNDLSEKMAFSNEEQLKIHEQLSKETRTFCQLVTSQSPSLIHRSREVSFVLKELDEVKRSISVGNATVYICGPSGCGKSELARQAALTLFNQHITAANDPAMVVAVLDAETEDSLLYSYIKFAKDILGNSLHIKVAVTSRGLMAGQKIRLLKCIIERQLKRYSKWVIIIDNVHCLEEFSSYWPKPGSEEWGCGQIIVTSTDSIATQTFCYQQSGHVTISRGMQPSEAIELLCGVSGITNKDDALEVAEMLEFQPLALSCAATFVKNLSGKNENGHWKTYQESFQKPRELYGKEFCQVNEGNHSELSLVAIKMLVDQLSAQHKLIPSILFLLSIFDPIPVNKNVILDCFKELDDTDVETTLQTLLSTPILDAENHQDNLAFLSSRCSKMCNHYIDLELTDARKISILGSAIRAVALQLNSPACFKSEANDTTYFQSFVADKLMSRVRKLNTEQRKELVEVLEKFGDRIAAADMLLDFGKQCQGIQSLKNAQMSFELAKEILLENGKIHSFFEPKLYSVLRGLGDASDNADVETKRYYEEALKICRNLKNDNDMHSLAEAIDDLGDVTISFGETTEAKKLYMEALELRKEDPDYDRVDSIYVSWFKLGNVYAIEGHFEQAKEHYEKALEIWDTYKSEALDCELVKVLTCVGAMSICVDEFDSALNYLKRAMKLEERLLGLYHPYRLSTIKNASNACKALGDTEQAEKLLKQSLEIFDKVVGSLDNEAAQIYSELGSLCAVKGDWETAIECHSRSLKIREETLCQLHPDIANSCCDLGNAYNNLGELEKAKTFLERSLGIRGLLFKRTHPDVGTSYFCLGEVYNKLDDHQTGLNLLERAVEIRTRNFGVQDPETLASIKLLGNSFARLGQLKRAKDLYQTVADEQSKFKDKETDLAHISSSLAEVSLGLGEVDEAKEQYKRAIDFQKRAAGDDHPEMARPIVGLALVHEHCKEFKEAKSLLEKALVIYKRNAKSHSKVLITEMHLKRVMAKLPQPRCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ID79</accession>
    <name>A0A6P8ID79_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metalloendopeptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116298854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_031563285.1">
        <property type="nucleotide sequence ID" value="XM_031707425.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298854"/>
    <dbReference type="KEGG" id="aten:116298854"/>
    <dbReference type="InParanoid" id="A0A6P8ID79"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
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    <sequence length="450" mass="49935" checksum="ADC8A3C5FE3B4DE2" modified="2020-12-02" version="1">MYNMKNMRAFLAAVLIFAAFAVISGKPQKRNCPHGPPTIDDVPGPRGPPTIDDVPGPHGPPTIDDVPGPHGPPLIPNDVQGPHDKETIEDHSDNDDMVTIDDMILPRKGLNILKKDGIITKRQAYISDDGQDFKWPKANGVATVPYTVGRGIDTDVLQRAIAVFSAKTCIRFVERDAQKNYVKFQIHXKKCGAQVGNGESGEQICYLTSGCSGKKGKVLHEMMHILSFLHEQCRPDRDSYITVHTDRIKSGYSSNFQIYKSKDLGIPYDCDSILHYRSTAFAASRXQQTITSSHCSHLGNDDTRLSLLDYKRVNTLYGCGKPDYKYYTVRVVTYSSWWSGTGTDCFIYLTLHGSQQTSTEFELDLSTNPSANLFESGSTDTFKYMAYRNDLGSITGISVRMVAHGSGQAWRPNTFTITDPDTGTSATFKNKNKQWLYPSSTYGTSNFPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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</entry>
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            <begin position="1759"/>
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    <feature type="unsure residue" description="D or N" evidence="3">
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            <position position="791"/>
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        </source>
    </evidence>
    <sequence length="1774" mass="196101" checksum="E6A3D77E985A12B8" modified="2020-12-02" version="1">MADQSEQEENLEPLVIFYDSEASNGNVYYGDVIEIAATCHPGVVVGSFERLINTKQNLGSFAINESGITEDLLEGMXFIDEVMYEFLDWIDEMVVLAQKKNNTCYFPVLCAHGGYQFDFLILFANLERKGMPYSKFSDCNIHFADSFLFCQKLQQDGNKYLQDTRLSIDGLFHKFFPKHTIKGRHRAXGDVKAMVKIFTQTPLKNVLNLMSVSTTLERIKYFVSQSSSKEQQLILEEKMSSLDACSRNMCSKRLIREGLTYDLLKTVFQKCSSYMDFWQTLKNIGIDRKVAKHFTSQFSAMGLENQGSLGYTLHAAMQNGSLSNGSSQNSNGHANTDVNGNLGTDNRNSTISGSSKSSLRTSKSNETYSSKAKVVIGTTGAERATSSSRAFEERPSDYAVTSSAGDERLKAYSLLRSALKQQDDEKDXSNNVLAANGRERKSCQETSTGVEFLSSENTSSSGDPSVCNGDENWDSEIENTVTRGHFVLQFNEVIPTSIVFEDVSSSSGGPSAEQHRDLKASNSKRAPMQPEANQKKRNIGNMKDSEQEKRHEHGQAKKGGESSVGFIKSRKNTKNQTTENLVRSNKMTKKEIPVTKNESKGDAVSSEDGKRGTLISSAGTXGLKQVDHNRSAGNLPKVTDGADDKTLSFPAKQIGRKVIVDQKGIKTNRRSKVSSKKTPSSVTFVTPVERASVDPSALLQGDVEMTTVYVGDFPILVPAQKQXVPCEDSLGQPTREDQELETGNRHISTDGNAISREEGITLQNVESPRNPTTEAEGMVLSKEIEGGNSVDRKLEDGRKQDMDGFEELAQYLEMTPLQNTTVPDKVPLTSTSESVSSSSYETSDTGSNLGSWHQTSPPLTEENNDQGKSSSNICPTDDNADTSGDQASLAIEQANHQPTAPTTEEHSPCDMETVETIKTDRDLENVCGDNENQAATDQGGLTVDPSSEADINPNMATQEQLNGFPECPWPSSDVVYPNPAMYPVPQQYPFQMPYPTAMPSAYGFYPSLPHMMTMIPGPQHAPYPPMPFASQGMMPFGGFPPRFPMAMPMFPPXMYPTGQEDQRXYLDMSEQETTQQTLSSSPEVLGIPDNRIQTLEHQNNKTPTGISNVXYSTSSDDHSARSSPFPLDDSSGMTTPLTTPHRSPIDDNSPGALSSSDKGGKSDLTQNKRKEYRKDARPARYHTDERSRRSNRNGPWKGSTYRDRKDLSEKGPRADLGEAAGDKTRGRDGGSKKRTKVKKEDSHSRHMQELSDQDIKLNSSSPKRPSNSPKSEQLTPRREARDVKSAHGTSKISPHNSRDVQSDHASPQASPKISRSEKLTPTRKVEEDHSSKTSRSDTRSEESGXSPKEKRNASTDPVIQQMASTISKSSQASSSKSAHXDSQKSQRSVEINKSWPKDRVESQKSSHTSKLHAPPSKTSTQVRTHPSXSTSRDRALEVGSISPKEAEKQSLPAQPLAMSDKKNEKLVSSEKEPKPQDQKDEANVTPSGSTNKEVAKHRPNESRNAETRNIKWPQSALANKKLKELPKPQRDPISRTRRVRDSHSSGSERENRAVGHRQGVISHRNEDVKGTPKSTDATAGENKFKDNKTASEKEQYKEPFSAFAKDLETKGEDRLHKNSTGHQRDSKSSNNYRDVLLGKQSTKPSSRTNETASSDSVKEGSSSAXEPRPHPQPATAVEKNQPMPESGTIKNLRGTPQPGDREKPLRKEHRQEKEXLKEQFYKESREVNTPRGSTMSREPTPSTNTRNPGRYRHCDTKNDNNFQSRNTVSKASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFS1</accession>
    <name>A0A6P8IFS1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC116300788 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116300788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CALHM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565589.1">
        <property type="nucleotide sequence ID" value="XM_031709729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300788"/>
    <dbReference type="KEGG" id="aten:116300788"/>
    <dbReference type="InParanoid" id="A0A6P8IFS1"/>
    <dbReference type="OrthoDB" id="5953668at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029569">
        <property type="entry name" value="CALHM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261:SF1">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14798">
        <property type="entry name" value="Ca_hom_mod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031565589.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31800" checksum="9BF3546D411C18EB" modified="2020-12-02" version="1">MNDLLRNNSNFKYSKKTARNILVIVFVYGIQELLRTQFFRCPCKNYALYSFIMVAAPMFFLLGIGFSSSDGYWSIVSRRKHITNNKLRLNYCLRSLPSLFEPFLPAAAFIVFVLMRGEYYACAKIGGRDGTCLAKQGLEQNLKTTAQEIAKFNTQSQLLGCGILAGITIFAVGILFIRNXCFESDVIPGSEEFRFMENQVFFAAFRDKMKDAIESEVKRDMEEAFDGMNNERQDAESVFRKARDQIYQKKSLKKVGEFSRLNFHEDGHSSPRVADSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH60</accession>
    <name>A0A6P8IH60_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EF-hand calcium-binding domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116301226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566111.1">
        <property type="nucleotide sequence ID" value="XM_031710251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH60"/>
    <dbReference type="FunCoup" id="A0A6P8IH60">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="116301226"/>
    <dbReference type="KEGG" id="aten:116301226"/>
    <dbReference type="InParanoid" id="A0A6P8IH60"/>
    <dbReference type="OrthoDB" id="10260455at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22976">
        <property type="entry name" value="DD_EFCAB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049760">
        <property type="entry name" value="DD_EFCAB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056587">
        <property type="entry name" value="EF_EFCAB10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24548">
        <property type="entry name" value="EF_EFCAB10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031566111.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15096" checksum="95B79FE63DE9A3DC" modified="2020-12-02" version="1">MAAKEENAKEYLRKHRIMELFENLTAHLVYERPDDLKGYICNYLEKLKTARTVQRGYPCLFDDSNIRSLFGMLDVTGKGHINYDQYKEGLSTFGIDSFDKDPPGADVDKINSETFTKEARQGLTDASSTFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHB7</accession>
    <name>A0A6P8IHB7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tachykinin-like peptides receptor 86C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566055.1">
        <property type="nucleotide sequence ID" value="XM_031710195.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IHB7">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116301173"/>
    <dbReference type="InParanoid" id="A0A6P8IHB7"/>
    <dbReference type="OrthoDB" id="5950491at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="9">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566055.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33142" checksum="94224B00465468BC" modified="2020-12-02" version="1">MMPSTQEAIFAVLFSVVLVFNISGNSIVIYIITNERGMRTSTNYLLLNLAVADLLFGVFLAPQFIFLPFIRHSVPDGVLGEWLCKLLLTCNIAWMASKASIFTLICLSVERYFAVCRPHTFRQHFSQKIVKVLVLVCWIYAVVVISPLFADTHWNKEYLDCSVKVPTSKVHSVYVLLEIICSLSLMTFFVMKIFLSLWCKQTVEPTGEREITDRKKKKKVTLCVLAVVVTFVVCWIPVAINYLLSGLLVSPVLSLAILVASLNAALDPYLFSFQSSKFKALVKKVLCCRKXSXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHT0</accession>
    <name>A0A6P8IHT0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fanconi anemia group M protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116301424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566376.1">
        <property type="nucleotide sequence ID" value="XM_031710516.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IHT0">
        <property type="interactions" value="1851"/>
    </dbReference>
    <dbReference type="GeneID" id="116301424"/>
    <dbReference type="KEGG" id="aten:116301424"/>
    <dbReference type="InParanoid" id="A0A6P8IHT0"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20077">
        <property type="entry name" value="XPF_nuclease_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031879">
        <property type="entry name" value="FANCM-MHF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047418">
        <property type="entry name" value="XPF_nuclease_FANCM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16783">
        <property type="entry name" value="FANCM-MHF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="123"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="516"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="843"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1578"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1845"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2005"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2175"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="846"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="930"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1207"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1268"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1867"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2005"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2028"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2177"/>
            <end position="2188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031566376.1"/>
        </source>
    </evidence>
    <sequence length="2550" mass="288382" checksum="1E07328C5D0A1B7F" modified="2020-12-02" version="1">MKKGNPNQKTLFQSWGKNEQQTLKTTEERKTQNHSDNIPIEIIDLEDXDEDDGLLAAALEMESIDPQINQNGIQNSNCAGNVSNSETSEEPKEVEYLPGFDMESGNVWIYPTNYPIRDYQFQIVQKALFMNTLVTLPTGLGKTFIAAVLMYNYYRWYPQGKVIFMAPTKPLVAQQIEACYNIMGIPESDTAQMTGNMAPNKREVMWKNKRVFFLTPQVLQNDLSRGSCCPEGVVLLVFDEAHKALGNHAYCQVVREISNYTRNFRVLALSATPGDDVKAVQQVMTNLLISHMELRSEDSSDIQPYTHSRTVDKIVVPLGDDISRIKTHFLKVLEGIVGRLFCNRALWQKDPQRVTKYMLLSGRDQFRKRNLEGYTNGQKGAIEGDFAMAISLYHAYELLHQHGILSFYNFIKAIIDGSKGMVRAKTEIKRNSQFMEVMEELRESIECPPDETAETSALFSQFTSPRRRAMHKQPFDPSFKSHPKLLKLEEVIVEHFLKFSSEAASTSTSVDNESATESKPVAAVNTRVMIFSQYRDSVGEITAILNKHKPLVRVMSFIGQASTGKSSRGLSQKEQLEVVQRFRKGGYNTLVATCVGEEGLDIGDVDLIVCFDAHASPIRLVQRMGRTGRKRNGRIVVLVSEGKEEQVYKRSLSNKKSIHKAIVQGSKSFELYDDNPRMIPRHLMPRVLKMQMTVGDFVGNRTKKRKSEANESKSTNITSFLGKPGTSKTPNLSRKDDGFLTYEELIYWQENFKLPNCEAGTTPQNSNRRRSRKSLTDPPVKELSLNEWMAWQNVPSQVYKIAHSRRTEHMIEILEFIELHGETGDGGDDAYDVEMMTFLNEADLPTPEDDAMIIGDDDGGDNERVNDSKDKTEKKNKKKRSVPNDNDKNKSNKNKKSKKSKSISPQQKTKWREYLKGFENEDNDFDTGEVESKNLEEKQSNDDEIRLEILDGEKEEAAKATEEILPEHNATELHEENEGFEVSSQNFSQLLPSLTPQKVHSLRSRITDVTDDHAKVVPLPPSLDSLDDISPFKFDKNSKSYDKENTRKLHKDKILSCRRNINLFNEPEVDDIGWEFGEKLLGNKNSKTNYRSRACANRNIEEPPHLDLEFDFGKEMDKKWENENGAKELTKNSSIPPCKGDLIKEPPELSFENEVVELTSEKENLMLENTKSSKMDRNLRGNSQWHGKGFSSEHSDSLLTGDDENDFQEKESPQSFKPKEKSGFGAGVVCKNKTSDVFEDDIEIEFGDDSLADGILADLDEEEFGRNSLDNHSKTGNNNQGFPSGTVSKSKDVRKNIHERHDLHIDTREAENKIDGEKHNSKCENVAKKSKLKLNSKEKSLGDNSLKKSILKLGAFERVNSAKNSFNYVIDSEEIFDHSTDKVMDAGNFENKSKAQSILTETNDHSGENLQRKGDFNFKKPDAILGNRSLKFNRSAVVSPKACRDTNHENAQTGSPVFTSSPIRKSLKLNSKVNLMKKNSSCGEYEEENSLKVFEMQKNQKRFSPFKESRSSPCASERYSCSFDVKHDEIQTKGNDDVHRSDPHDSPILRKPLRERLANRGFEDTVNDINITKRNQKDSDIISNDDDSSPIIRKKSKSETSNVTAISPLQESQNISRKVDMEDGESPLVRRRSKAKIRDGNVFAIAESDEEFENDIQKTDSQFLEHEAFDEVKSHGASDDQRDRSVNKIIGLRNRKLVGASDSEEEFLVENRKDYVQGVGARHDVQRKIVLQNSVKRKRLCSHPPSKKQKRLHANHFLDEEAELSGSDIGEFTDDESDLGSEFDSFIDDSSQLTQRTPTCRTSRVPRSPMDMAALYRLSLMSPHARNLNFRTPNFRSNKNRYKMNFKPKRTGSESEAEETHAHESDLENEMEFDSEEGYFEEEEYEEESVYGDENESPDNSVALVQEISPHTPSQVRRPLKRPKRKYVLNDSVDEDVTVCKKTPLKTNIRSNASCSALQSTQAFTYKKSLPTIPPKTNSFTASSSLLSKENTPICIALPASIGPEREADTSNQNFKERRSILSSKAADSSKKDGDKTRERNSLSTTFDFDWDSNGFSDTDLLEAMENSDKYDGLSKAGSNRNTSTLRNIKSHLIQDQEMQDIALAMAATDDDMNFEMSEMPTFSLGLDFLGDDTEEKEQQSVVLQADQNLNNSAFSSEKNKSVLKDSPFALKRQSPLQKQKQQQLQQQNGTQESKFTKIVAPQRSGESNTRVFSFKSSCAATVQPFSEGIQNLTTNSQNINKNISRSSTVCSSDIMGKGLQGYSSSGGRLFENKGVSEEKSTAHTAISTDKDKHHTTLCLDTSTPNSTPKNIPRAFVSPSQRDRDKLVILVDTKEICNVQVVSCLRRKHNIKAEVCQLIHCDYVVSNRVGVIRKLVSAVANGANSTKLVDKMRLMCDLYDRPCLIIEKDRVKPGEKERDWSRSHAYSHTLACIAQTHIKVLFSESQEETAALLTELASMESKKKAAIQAPLSLNKETQQVFRFLLSIPRVSYITALNLCSSLRTLRDLISSTPDDLQKITKQLSQSRATEIYNYLKHNFDEAMTARKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK95</accession>
    <name>A0A6P8IK95_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase TRIM71-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116302254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567346.1">
        <property type="nucleotide sequence ID" value="XM_031711486.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IK95">
        <property type="interactions" value="1231"/>
    </dbReference>
    <dbReference type="GeneID" id="116302254"/>
    <dbReference type="KEGG" id="aten:116302254"/>
    <dbReference type="InParanoid" id="A0A6P8IK95"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
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    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00643">
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    <dbReference type="Pfam" id="PF00097">
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    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
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        <property type="entry name" value="NHL repeat"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="133"/>
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    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="404"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="499"/>
            <end position="538"/>
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    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="543"/>
            <end position="586"/>
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    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="636"/>
            <end position="679"/>
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        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031567346.1"/>
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    </evidence>
    <sequence length="724" mass="82417" checksum="BE41BFD5CC7143CF" modified="2020-12-02" version="1">MESFVDDLKKEVQCSLCNDTFTEPKILPCFHTFCKPCVKRHADLIDEVNVFKCPRCKLTTSLPEPSSVEDLQPSLLHTRILKGLALVEGEKICSVSESHSTASWYCFDCDRSMCEECKKYHSEFTKDHKVVRLADLEQEDIGFIITRENPCKSHPHHRLELFCEDCDDMICRTCLIHDHKDHKTMLLDELASRKKTVLSKYLKAIENLMLNDKEKQEQEEIAYNIKQQGDKALKQIQEKTKEMIDTLREKERELIKQVVESSEKAERNLNIIHHMPAVKEYINRIMERGLASEMINYIQETQCSEDYILNPISRYSRIVFVPNEKLMEEVYXGLGEIQSYSETDHTMSFIQVEYKPAVALRRGKLKLISRSCIGEIISDPLDVIDVQIKPEENVKXEKKYVRTDGKVEVEFMARVAGQLTAEVQVNENHVSNSPLVVNVKPQEINVRMKLNLEGPTDTQPKLLNGIAVNRKNSRVAVAYESAHCVHVFTTDGDLLLTYGSRGSAQGQLSNPEGLAFLNDTDLVISDNGNHRICIVNTTTGTLVKTFGNHGNGDGEFRYPYGVHVDNDGNIIVCDRNNHRVQVFTRDGDYQYQFGLTDDDIFTPISTVSHGERFYVSDTVRHVIHVFEKKGNIMTGISTIGGEGSADSQLKRPWGLAIDKDHLLLVCDHENNRIQKFTLDGRLVGKTCNEVDHPAYIXVMNDGQLLLTSYINGVYMSFVDRGVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IN80</accession>
    <name>A0A6P8IN80_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gamma-aminobutyric acid receptor-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG8 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_031712454.1"/>
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    </dbReference>
    <dbReference type="GeneID" id="116303016"/>
    <dbReference type="KEGG" id="aten:116303016"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gamma-aminobutyric acid receptor-associated protein-like 1"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
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        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568314.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="14074" checksum="1AAD5DDD52AF05E0" modified="2020-12-02" version="1">MKWEYKEEHPFEKRRAEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INJ5</accession>
    <name>A0A6P8INJ5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide Y receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116303082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568392.1">
        <property type="nucleotide sequence ID" value="XM_031712532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INJ5"/>
    <dbReference type="GeneID" id="116303082"/>
    <dbReference type="KEGG" id="aten:116303082"/>
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    <dbReference type="OrthoDB" id="10628289at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031568392.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47956" checksum="35B3414AD3C0B6EB" modified="2020-12-02" version="1">MAMVQEMTLLLIMVSGLLGNGLIIRVICGDVLMQTMGNKFAFIMAVSDLGLCVFFMPFSLISLFRYQWMFGQNMCHVTAFCGEFFTKVSTATLSVVVLEKHSNIVQRKLKKFSRNGVLMTFFVVCITALIFSVPYPPREAVYDDCLGNCIMITSSGASLESILTFVLLEGLLFKVVSVSLLLVSLLKVFKKIHMRRCMTHPRQKQNLINVDQLRMMAEDYTACTTLIVVASHVLLCLPYITIQLISIRPNIVIPHSWRIIAFWLLLFNTSLRPLIYGLRNRRSRNLMLQYFKRAKRNVITQNCFMKLGRRRKAYVVPVTAQQQTEQTNVEELMQIVDVMDIAASNTPLFTRRRIMTVPTINTTTEQTFLDLNFVPDESQIELQSVPNDRYEMMSLARRIESKDDDLCIQDIETQDSASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INQ1</accession>
    <name>A0A6P8INQ1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adrenodoxin-like protein 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116302765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567993.1">
        <property type="nucleotide sequence ID" value="XM_031712133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INQ1"/>
    <dbReference type="FunCoup" id="A0A6P8INQ1">
        <property type="interactions" value="1029"/>
    </dbReference>
    <dbReference type="GeneID" id="116302765"/>
    <dbReference type="KEGG" id="aten:116302765"/>
    <dbReference type="InParanoid" id="A0A6P8INQ1"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000013">
        <property type="entry name" value="Adrenodoxin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031567993.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20035" checksum="65E095C6FE66A2AE" modified="2020-12-02" version="1">MLATNRAFSILGLTFSSFRRLFMPAARTNNGYLKRNFHISRGPLLTGDYEWQDPKSPEEVVNITYIDSKGNRTEVKGKVGDNVMYLAHRYNIPIEGACEASLACSTCHVYVKDEYMDKLNEPEEKEDDMLDMAPFLQENSRLGCQIILTKDLEGLEVTLPKATRNFYVDGHVPQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP04</accession>
    <name>A0A6P8IP04_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EGF-like repeat and discoidin I-like domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116302850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031568098.1">
        <property type="nucleotide sequence ID" value="XM_031712238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302850"/>
    <dbReference type="KEGG" id="aten:116302850"/>
    <dbReference type="InParanoid" id="A0A6P8IP04"/>
    <dbReference type="OrthoDB" id="5980646at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="163"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031568098.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34542" checksum="01095098A60786B1" modified="2020-12-02" version="1">MEATALIQVLQLFYFFFVLFEITTCTVDVSLRVGKQGPFTYGNFDKRIKGSVLRKAGSLISTLEVDSDIECVSFCVMSAVCLSVNFASEANSKTEKVLCELLNYGGTDYRKFLNKKEKFFFMRMENICSENPCMSDVLVCTPQLQNSYQPYICDCPGNCTGNIKCHALGMEDGRILDSQITASSALSSSXAAHKGRLNNAAGSWLPSSTVSQWLQVNLLKKTFIKGVASQGRHDANHFITAYQLSYSDDGTNWTIYKEKRIVKTFQGNANYATIVKNLLTEPFTAKFVRLLATSYSGYPSIRMELYGCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR66</accession>
    <name>A0A6P8IR66_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304096</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569611.1">
        <property type="nucleotide sequence ID" value="XM_031713751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IR66"/>
    <dbReference type="GeneID" id="116304096"/>
    <dbReference type="KEGG" id="aten:116304096"/>
    <dbReference type="InParanoid" id="A0A6P8IR66"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569611.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18828" checksum="3FCBECB1766E51B3" modified="2020-12-02" version="1">MAQRKVVLAVDGSPYSDEAFNFYCDNLHKAGDLILVIHAFEMPTMPAAPYPYGFAYYEEWSNLVKKADEEANEMLRVIGEKCKEHSKKDDKYKFELYKEGGRAGEIICNFAKEKGAEFIVLGSRGLGTIRRTFLGSVSDYCVHNAHIPVVVVRSTPKDDAVAEPGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRG9</accession>
    <name>A0A6P8IRG9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein regulator of cytokinesis 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569574.1">
        <property type="nucleotide sequence ID" value="XM_031713714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRG9"/>
    <dbReference type="FunCoup" id="A0A6P8IRG9">
        <property type="interactions" value="1369"/>
    </dbReference>
    <dbReference type="GeneID" id="116304062"/>
    <dbReference type="KEGG" id="aten:116304062"/>
    <dbReference type="InParanoid" id="A0A6P8IRG9"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569574.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="74767" checksum="3382CB83E381E597" modified="2020-12-02" version="1">MEPHAPLATIDESFKENSVQMIKTELVGCLEGSMENLQQIWNEIGISEEQKEERTHVVLKHLQTLLQEMVEEERQLKTTLMENVKTCSADLQQLSNELGIEYPTFPEGISILKLENDLRTKVDEFKVEKHKRIKELKKLREQENVFCKRLCLPAHNFGQNFVVPNKEHIRELEANIEYLKNEMIKRLESFKKIKANVMELWKELEEVPKTTVETEMAMDSAETTFELSAINLEALKVLELELEHQKTININISKQLREEIQSLWTKLEISENEYKPFLAHWHGFKRSTINAMESEKQRLQALKLKHMQKFIEGLRKELTNWWDKCYFAPAQREAFSPINDTDYTEELLNMHEHQVEVMKSFYEQNKHLFKMVEKRETMFAKMAEYELKKNDVNRFSNRGGALLKECRARKVLEKELPKLERELKEDIEKWETDNEQQFLVNGVQYTDTMVQQWENMKLEKEQMKLERQKKHQDIMKEELLFGSKPVTPTKRRFIGTPSKTTPNKQRKMDTTSTPSRVTLASMCQSPCKTKSSGRPPIGSSTKKQGKVSRLVTKAKVTPKRVSARLKAKRQVLGESSVLNVSKKLNDSLGMVAGSKMTNDKNTSLMSCMDYNDFAVGLENIENEKNKCRSSLLVAENSMGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRW0</accession>
    <name>A0A6P8IRW0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116304308</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569886.1">
        <property type="nucleotide sequence ID" value="XM_031714026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304308"/>
    <dbReference type="KEGG" id="aten:116304308"/>
    <dbReference type="InParanoid" id="A0A6P8IRW0"/>
    <dbReference type="OrthoDB" id="5951291at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569886.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="20106" checksum="E442022600470646" modified="2020-12-02" version="1">MENVNSVEIYDCEELEPNANEEEIAEFNEQSRIELEEEEXLRRRFCGESRQWCTCSNCCLTLVTKQEECFCCNDIMRCMDKLNELDQQVQCITCHPGFESVCLDKFLQSVAYRQFFRFIWDFTGNSKRLPLPCCVYNSIRIAFPSEDGSYRGFLERRRRTSSVKRRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRY5</accession>
    <name>A0A6P8IRY5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC116303691</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031569132.1">
        <property type="nucleotide sequence ID" value="XM_031713272.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569133.1">
        <property type="nucleotide sequence ID" value="XM_031713273.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569135.1">
        <property type="nucleotide sequence ID" value="XM_031713275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRY5"/>
    <dbReference type="GeneID" id="116303691"/>
    <dbReference type="KEGG" id="aten:116303691"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000114">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF893">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519127" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="10">
        <location>
            <begin position="65"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="9">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="433"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031569133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031569135.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="67325" checksum="1F3BCDD959F5B0C4" modified="2020-12-02" version="1">MAVFYLVTVLLLVGHALGEGPFDGKKDQLHYMTPDRSIFEGDIKLTPEQTRNLEAFGDPTFLSGRAANNNPKKLWPNAVIPYEFDCSVSSLDWGIKAIKAGMAEWESKTCIRFKPRTNETNYIWFYRSLGCWSEVGMTYGRKNYLSMGKGCDYQHVMTHELGHAIGFWHEQSRPDRDSYIKILFENVQESMKYNFEKRKWGTEVIDYNVPYDYGSIMHYPWNSFSSNGKDTIKPIRDLKGKTPYVALSDDDALQANRMYKCPGFLKKARNLKTQKQKPIAMPKASLEARSASCEDRSDNCADYKQTGLCEKHGENLFYWCSKTCGHCISAHCKNYEFECIQWAKEGKCQTEKEKMKLYCPLSCKFCNKCTKPKPTPSLAPRTGVGLRCLDKYDKCSDYAHLQQCGTTAWIDFNCRKSCGTKCDTYPVKPEGSCSNALGLGWPGDYKLPDANFFATSNFKPGDWSAAADNARLYQEDDSSRKRIGAWCATERDNQYVGVDLGKDMRVRAIATQGRDDSHEVVQKYKLSFSSDGTNYRFYQENGSDKVFDGNCDFFTPVINTFTPTRARYVRLHVVKASYPCVRMELYGCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT06</accession>
    <name>A0A6P8IT06_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger MYM-type protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569415.1">
        <property type="nucleotide sequence ID" value="XM_031713555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT06"/>
    <dbReference type="GeneID" id="116303931"/>
    <dbReference type="KEGG" id="aten:116303931"/>
    <dbReference type="InParanoid" id="A0A6P8IT06"/>
    <dbReference type="OrthoDB" id="5990539at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="157"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569415.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43244" checksum="24BB02FADCF63566" modified="2020-12-02" version="1">MAKQRSIGEFFKADLSKENNSVEVVLDQHEAANSSNEQITSVEELSPKIGPKESELATGLPKRKIASKIRCFREEWYNNNEWLEYSTALHGMICFACRLFGGLSKDDNWVRSGVNNWKKATEKIGEQSQSAFHQTNLIKWKSYSNLKKPIDCILDEQKEKERSARAAQIERNQQIIIRISDVCKFLAKQNIAFRGHDESKDSCNKGNFRELIELLAKYDPLLNEHLLKAPKNSTYLSPEIQNSVIETLGELILSSIVDEVREARFFAIMVDETTDISHHEQMCICIRYVNTQTTEVQERFVGFLQVANITAATLYDTIVQYLQKFNVDLEKIRGYYLMLSRKIIFQIEIDKELLAFNDGTEKAIFTSNDFIGERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT17</accession>
    <name>A0A6P8IT17_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase MPPED2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570067.1">
        <property type="nucleotide sequence ID" value="XM_031714207.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IT17">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="GeneID" id="116304469"/>
    <dbReference type="KEGG" id="aten:116304469"/>
    <dbReference type="InParanoid" id="A0A6P8IT17"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570067.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32573" checksum="C6BE46402DBCE4A6" modified="2020-12-02" version="1">MALMKFLKKKSPSSKLDEVVKEHAEEPNKAWSILQVSQTVKEVEPMDPSTPKPPNHTRFVCISDTHSVKNFEHPIPDGDVLIHAGDFTMLGNMKEINXFKKFITSLSHPHKVFIAGNHDLIMHGEKYEYLYSYWGTSVGEKGDPVEAKKLLDTTKLTYLEDSEVTINRIRIYGSPWVPDFGNWAFMLPRGEELKEKWNQIPDGIDILITHGPPLGYGDLCFTQARAGCIHLLQAVQNRVKPKYHIFGHIHEGYGIQTNGVTTFVNASTANIHYQLKQKPIVFDLPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU92</accession>
    <name>A0A6P8IU92_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAAX prenyl protease 2</fullName>
            <ecNumber evidence="11">3.4.26.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Farnesylated proteins-converting enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116305096</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031570826.1">
        <property type="nucleotide sequence ID" value="XM_031714966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IU92"/>
    <dbReference type="FunCoup" id="A0A6P8IU92">
        <property type="interactions" value="1688"/>
    </dbReference>
    <dbReference type="GeneID" id="116305096"/>
    <dbReference type="KEGG" id="aten:116305096"/>
    <dbReference type="InParanoid" id="A0A6P8IU92"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="14">
        <location>
            <begin position="154"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031570826.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34143" checksum="69822438F86399F6" modified="2020-12-02" version="1">MVLLAREFKMADAVAPFVSFNNITYFRSFVACFVIAVGYVASLYINKSPLPRDHPKTIYQRFKSVAVVSLSAPVYVWLWSDNRLQTNQEHAVYSLWRWLGIHVSNTLTAAALPLFLTIILFLGPLLLLLLNGDVKLKLSGYFKYNSMLLDSVQIRNYIVAPLTEEFVYRACMLPLLVPCFGVTTSIIICPLFFGVAHVHHVIERLCVNNEDPKEVWLSALFQFGYTTVFGAYSAFLFVRTGHLIGPVVCHSFCNFMGFPQVEEVPNSKYPKIIAGSFVVGLVVFLLLALPLTEPSLYGSIYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVL1</accession>
    <name>A0A6P8IVL1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antileukoproteinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570150.1">
        <property type="nucleotide sequence ID" value="XM_031714290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304543"/>
    <dbReference type="KEGG" id="aten:116304543"/>
    <dbReference type="InParanoid" id="A0A6P8IVL1"/>
    <dbReference type="OrthoDB" id="6042169at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028213501" evidence="1">
        <location>
            <begin position="29"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570150.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20843" checksum="CCB956D2ED4DE3B1" modified="2020-12-02" version="1">MARIANQATLFLMAFLLLNTEYHVSVHAMPTSRPPVPPTNTSSLVLVIPGECEVFPPGECQHFTSNECENDQQCQDIYLDYPGLKCCENYCGIRVCDLPLKIPAINVITYEIKEVVYTEFVCPEVIPQPECPLEADLDNECDQDNECSAGYKCCTDFCGERXCEMPVSRVVRQLSTGPLEDPKLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWP4</accession>
    <name>A0A6P8IWP4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116305723</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116305723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571549.1">
        <property type="nucleotide sequence ID" value="XM_031715689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWP4"/>
    <dbReference type="GeneID" id="116305723"/>
    <dbReference type="KEGG" id="aten:116305723"/>
    <dbReference type="InParanoid" id="A0A6P8IWP4"/>
    <dbReference type="OrthoDB" id="5979632at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF12">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571549.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21318" checksum="E07E83945E665D7B" modified="2020-12-02" version="1">MSGSSLKFEVDASGRPYATMAHDEATKNHPGGINDINSSEKKARMYETDYPNDGYKALRLYLSKTNPNCESLFQYPKRNWSPTDDMWYENRPVGVNKLNGIMKEISKEAKLSRLYTNHSVRATSITVMSNAGIPNRHIMAISGHRNEQSLAHYNTRPSTEQLHHCSETLCCPKVSLPQAKRLSRLLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWQ3</accession>
    <name>A0A6P8IWQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Patched domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116305679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571502.1">
        <property type="nucleotide sequence ID" value="XM_031715642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWQ3"/>
    <dbReference type="GeneID" id="116305679"/>
    <dbReference type="KEGG" id="aten:116305679"/>
    <dbReference type="InParanoid" id="A0A6P8IWQ3"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="784"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="283"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="729"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031571502.1"/>
        </source>
    </evidence>
    <sequence length="897" mass="100691" checksum="931CA41F555841AF" modified="2020-12-02" version="1">MEEEKTKSQERSKTCRCSPHSLWVTFSTMYINIISRCFGVLGTVFSRHPCLTLAVSFGFVGLCSVGFYWMNAENRVEKLFIPRDSRAMKDMDKAKINFPMESRIETVIFEPKEPGQYVLSKACLLDVLAVHHEIINTKPYQELCLSQPSTNNSPSFCLFLNPLDLLQFNQSLFSNATRKFEEAFRNKGLMMRNGRPFWYNMRIMFGGLDIDGVSGEMSKIDALQVLYFMKDGKTEPEEEKITNWEKNVVENIEKLGDALSCVKVYVNVQRSLDDAIQESATSDVAFIGINYMLLFSFACFMLGKFRNPLTGHMLLATIGICAVLLGILAGFGFSMFVQTPFTSVVGALPFLVVGIGIDDMFVIIDELDRIGPQLSVTDTVKVVMANSGATITMTTMTDLVAFAVSTWSDLPVIQYFCLYAAMAIFFAYLMIITFFVAMMTFDVRRVKAGRRDCFPVCRVPPPKEGAPAWDEPRTQTSSKLLKAWAKILMRTEVKCIVVLISLGLFGSGIFGALKTNEEFDTRLLAKDGSPYMLFTNAQERYFPLTIEVSIILDTEVNYTSPETQNEIIHLSRIASQNSFYEKTTLSWMETLAAFSKKRGLSLEGKHFMTTLRTFLNISSFAHFREDLRLSDDKRTVRASRILCYMKKSLNSIGQRNAMVTLREDLQNGSLLPAYAISKSFIFFEQYTRILKATIINLVIASIAILLITYPFLVNFSVTIMVFFGFVALVFELFGLMYIWNISLHGVSMIILVMAIGFAVDYSAHIAHAYVMSSKKSAEERVIDALRTLGASVLMGGTTTFIGMIMLAFASSELIRIFFKMFLGIVLLGLLHGLCFLPVYLTIFCRGSSFKTSDVANKIEPDLAESTESAGVTQQPRKNNNVVASYDNPVVTTEQNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYP9</accession>
    <name>A0A6P8IYP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116305212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570930.1">
        <property type="nucleotide sequence ID" value="XM_031715070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYP9"/>
    <dbReference type="FunCoup" id="A0A6P8IYP9">
        <property type="interactions" value="2096"/>
    </dbReference>
    <dbReference type="GeneID" id="116305212"/>
    <dbReference type="KEGG" id="aten:116305212"/>
    <dbReference type="InParanoid" id="A0A6P8IYP9"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000003">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031570930.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="50425" checksum="1F6262BACDD1AC25" modified="2020-12-02" version="1">MALRVHVCTWNVKTTQPPEVDLRELLHLDNEEDIPDIVAVGLQEVDAKPQSLLIEYIKENSWVKILQAYLGAYGLVKLRSIRMLGMVHLISVHSRHLPYVREIRPGYCKTAFLGLLGTKGAIAMRFSIYGETFCFINSHFAAHAEYTEHRNMETQTVEDYITFPNCTPQKINEHSYIFWFGDFNYRINESAENIKALCSQQQYSTLWEHDQLLSSQKENLCFVGFKEGPLSFPPTYKYNVGTNDWDTESGKFRKPAWTDRVLWKEKQEKANTVQLITYKSHDQYMTSDHKPVSALLSIDMQESMTELENPIEWKMDLMSMPWYGNEDGLCVYIVKNYKTYSWDWIGLYKVGFHHLWDYEMYEWAVGDGDEYGENGCAVLFDCLPEEAGHYVMAYYSYKMDAVISVSEPFEILPPRDEDKDPVDVQVEQPQEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ21</accession>
    <name>A0A6P8IZ21_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein cep57l1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571045.1">
        <property type="nucleotide sequence ID" value="XM_031715185.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305304"/>
    <dbReference type="KEGG" id="aten:116305304"/>
    <dbReference type="InParanoid" id="A0A6P8IZ21"/>
    <dbReference type="OrthoDB" id="6022105at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571045.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="63213" checksum="7D9F5E1327036C59" modified="2020-12-02" version="1">MTAPFLVPGQQNFEAKMNENRGPMKEYYYEDMEAMSQTAREVWLAEQCSAFESELRRMSELMEKENLIXELYKKLKQVTRRWQSWNHRSFGGVTSRGYVMELHSWEKNIKSRGLLFPKLPSITSPDTNILEKFEDWCERYEELLNCFTKAVYEPLRDFXLNEKMTGTLKGVPMELDKVLKNWKELLSVGVINEKLFSTSSGKKVYLVAIRNKCHDFDLILRLIPDLSEKAYEVLRLARRWRLIYRSSALPRREETYIVTKGLERSQRRSRNKVLQRVKTLEMELQQSQAHHKALVAELEESNAKCAAIEKELSNYRQQCNQLENELDSVKKRCENLKQKLDAAKHENDNSNAAIESSAEYIKVLQKELNGSKMKYCVQKIKFINAKRHYSQLMKELETTRENLXSLQSELVLSKKKCEALKAQLDNAKKNVFTQSNMLDVLQNQCFTLREELEGTRAKCNELSCELGKSQDKCESLVKELELVKDQCHSLNTELRRAKTREELLIQQNEQLRAFCQEKGLGEPTLSKFGKNTLNKPDSESSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ27</accession>
    <name>A0A6P8IZ27_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116306500</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116306500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572434.1">
        <property type="nucleotide sequence ID" value="XM_031716574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306500"/>
    <dbReference type="KEGG" id="aten:116306500"/>
    <dbReference type="InParanoid" id="A0A6P8IZ27"/>
    <dbReference type="OrthoDB" id="6151791at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028001">
        <property type="entry name" value="SAXO5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34828">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34828:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15373">
        <property type="entry name" value="SAXO5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031572434.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16644" checksum="E028AA834C733FBC" modified="2020-12-02" version="1">PAVGHRNTLVKGSHLRTKSNVXLGHCASSKYYDTSMKTDYTALPNIHKNPQIGNSNNSSLPLDYYRGFVGVPTTWNDFQSHAGIPKLVPNPLSLQNLKMSHIQPQIPGEREFSTTHQRCYTPKKSSRVDVKLGSLQRSSVPLGNLNMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ40</accession>
    <name>A0A6P8IZ40_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116306509</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116306509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572449.1">
        <property type="nucleotide sequence ID" value="XM_031716589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306509"/>
    <dbReference type="KEGG" id="aten:116306509"/>
    <dbReference type="InParanoid" id="A0A6P8IZ40"/>
    <dbReference type="OrthoDB" id="5971203at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF46">
        <property type="entry name" value="INTELECTIN-1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572449.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25649" checksum="71C68BC41C116341" modified="2020-12-02" version="1">MEIRDALGFSPRNPILSCKWFKNLDNQVNSGVYWMKFNEPSSAPFQVFCDMTTDGGGWSLVYSYTFSDFDNFNTDDNVITPVPNWPLYMSPANEWSPISTTTPLNESSYSAMDFGXWKKIGREILLKCNITNWVACVEGTGRLVDWVAGSLTCRVVKAITPTCTTIAPDSFEFWGCGPAFKNSASNSYQFVLDAQLKLHQCYPMHDPCAQNSANHLKNVTSPGCALYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZM0</accession>
    <name>A0A6P8IZM0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116306680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572622.1">
        <property type="nucleotide sequence ID" value="XM_031716762.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306680"/>
    <dbReference type="KEGG" id="aten:116306680"/>
    <dbReference type="InParanoid" id="A0A6P8IZM0"/>
    <dbReference type="OrthoDB" id="5966159at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF222">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031572622.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51416" checksum="9E620EB6AD198EFE" modified="2020-12-02" version="1">MVEEIKIDAENFPSYTTVHGIKFAVRGNHPVRRVLWTLTILLTXAALLRQFYVSIEKVSKKDSTITTTVRQDNVIKFPAVSFCNMNMMKKSKIISTDSQVYLDKMDFFRTPDANQSFXTSIFDIQEAVRQNGXELKDMIINCFWGSEKCTEKNFTVFYSFHRGLCYTFNSGKPGHPLQYAQGPGLENGLILTLDAEVDEYYGMFSYRGAGFQVLVHDQDDYPGIEMNGFELSAGFKLSYSMKKEKFIGLPLPKCHEKKSQSSANNVYSQSSCLTKCKMVKLKKACECXIFSAPEIEELSGLPPCNFANDKDQACVLKFFQASRNLECKCPLPCTREMYRGHSMVSTYPSPHFWTTYEENKKKGQLNKMMAKFDGLNKDSLTQLEIFYSSPEEKIMEEILVYDYDDLISDFGGFLGLFLGCSCLTLCEFIDFFITWCRRRLHKDRITVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0Y4</accession>
    <name>A0A6P8J0Y4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116307130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031573144.1">
        <property type="nucleotide sequence ID" value="XM_031717284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0Y4"/>
    <dbReference type="GeneID" id="116307130"/>
    <dbReference type="KEGG" id="aten:116307130"/>
    <dbReference type="InParanoid" id="A0A6P8J0Y4"/>
    <dbReference type="OrthoDB" id="5977689at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="7"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031573144.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="62312" checksum="72D359877E2AB02B" modified="2020-12-02" version="1">MSVTVGKLKFLDSQQFMADSLANLVKYNTDFPISSQYGAERKGVYPYEYMDSWERFEEPLPPKQRFYSTLNESGIKDEEYQHALDVWEKYSCENMGNYHDIYLRSDVVLLADVFQSFRKMAIEYYGLDPANFYTAPGLSWSALLKKTNAQLDLLTEYDMYRFMEDGIRGGVCGPSRRYARANNPAVEYDPEKPTTYIFYLDANNLYGWAMSQYLPVRDFEWDTVRPIDFYMQVGKEEDKGYVLEVDMEYPEHLHDEHDEFPLAPEAIEIPFQQLSPLQKQMCPGYKPYRKLTMNLMDKKKYVVHYRNLQFYVKHGMRVKKIHRVLKFTQEPWMRSYIDFNTKKRTAAKNDFEKNLFKLMNNSVFGKTMENIRKRVSIKIASTREEAEAYVSQPGFVRYVEMLNFYVIHMKRANLFLNKPVYTGFTVLDLSKLLMYEFYYDKLKPKYGDRCRLLYTDTDSLILEVQTEDVYQDCVEDIDEYDTSGYPKEHFLYSAKNKKVIGKMKDEMLAVSSDTLAAAASFLIADTPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1V3</accession>
    <name>A0A6P8J1V3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116307396</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116307396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573509.1">
        <property type="nucleotide sequence ID" value="XM_031717649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1V3"/>
    <dbReference type="GeneID" id="116307396"/>
    <dbReference type="KEGG" id="aten:116307396"/>
    <dbReference type="InParanoid" id="A0A6P8J1V3"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14813">
        <property type="entry name" value="bZIP_BmCbz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="201"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573509.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29819" checksum="41BFFEE167B0C4DA" modified="2020-12-02" version="1">MAIWRPFKVKGQRCTMNIVTALLATTNPGVVFDNGAFGLASPLPFTDLLEISSQDKEEREGDGWVGWKQGSYGQPFFDQVAELESILTNLDDSDSLKTPGCCLNLLNEKTEFIQEVPAFISNLKESPLILPESSFEDLDLPSSTDILESPDEDVESIDTGSSTSDKVAGLESLDPFASAKEARPRKQGKSRSSPPMDSFMKTLDKRIRNNQASKKFRKVRKGKQRALFDKVQELANENYELKVQMEKLVQEIDQLKANIPEDIQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2C6</accession>
    <name>A0A6P8J2C6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116307610</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116307610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573742.1">
        <property type="nucleotide sequence ID" value="XM_031717882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2C6"/>
    <dbReference type="GeneID" id="116307610"/>
    <dbReference type="KEGG" id="aten:116307610"/>
    <dbReference type="InParanoid" id="A0A6P8J2C6"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031573742.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18366" checksum="4892BC4B9E7DC897" modified="2020-12-02" version="1">MAERRVVLAIDGSNYSDEAFNFYCENLHKENDLILVIHAFELNIIPTASYPYGLVYAEQWSDLSREANEESEEVLRKIGRKCEEHSKQNDKFKFELYKEDGKPGEVICKFAQDKKAEMIVIGCRGLGAIGRTLLGSVSDYCVHNAHIPVAVVRSSSPEEHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J384</accession>
    <name>A0A6P8J384_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DDB1- and CUL4-associated factor 10 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat DCAF10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572478.1">
        <property type="nucleotide sequence ID" value="XM_031716618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J384"/>
    <dbReference type="FunCoup" id="A0A6P8J384">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="GeneID" id="116306539"/>
    <dbReference type="KEGG" id="aten:116306539"/>
    <dbReference type="InParanoid" id="A0A6P8J384"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039085">
        <property type="entry name" value="DCA10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14588">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14588:SF2">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572478.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49587" checksum="ADEE591FE1C41030" modified="2020-12-02" version="1">MGEFKYTTTEATNHETTTSWSSYKYLRERENGVQYRNDSVVANYYKYMSLKSIWGKNRDGCEDHGAIFNTEFSPDGKLLLAACERSAFLVFDPLNQKLILTRSGAHNDGINCIRFLDSRSFLTCSDDKTIALWDARNLKSKVSSFVGHTSWVKSIEYCRSTKQLVTSAFDDTIRVWDLNRPSPSGFIEGRSVLKVARLTRMKLTPCGTKMIISSIAGHLVVIHNLDLEQLEARSGDHGIPFWNFSGTYHQKAHYLPCTDVPWSAKNKFEVIEEFPEDTKPWCISSLEVHPHGWCIVIRYTGGDWHQEWTALYDIQTKGKQSTDETDGAECDISRPQRLIYCIEEPNVARGYIKEPCFSNDGRVIGSPFGNTSRLLTFSQNCEELPNCLKKKTSRLIDFKTLISHKHPVLTSRFSPTHPILSSGCRGGKVAFHYPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3J9</accession>
    <name>A0A6P8J3J9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116306649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572588.1">
        <property type="nucleotide sequence ID" value="XM_031716728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3J9"/>
    <dbReference type="FunCoup" id="A0A6P8J3J9">
        <property type="interactions" value="3101"/>
    </dbReference>
    <dbReference type="GeneID" id="116306649"/>
    <dbReference type="KEGG" id="aten:116306649"/>
    <dbReference type="InParanoid" id="A0A6P8J3J9"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000006">
        <property type="entry name" value="NTF2-related export protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572588.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15384" checksum="3FBEF4653DDB5FD2" modified="2020-12-02" version="1">MAAKSGEMRETIEQAAQAGERFSELYYQTFDKSRHKMSKFYSANATVLWNGNVVKGEPDKLMDFFTNLPSSQHTLHSLDCQPVTDQAIPGHKTILVIAEGSVKYDGHKVENFSQNFLLTVEGTVWKVASDCFRYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3K5</accession>
    <name>A0A6P8J3K5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116306282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572165.1">
        <property type="nucleotide sequence ID" value="XM_031716305.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116306282"/>
    <dbReference type="InParanoid" id="A0A6P8J3K5"/>
    <dbReference type="OrthoDB" id="5963713at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="531"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572165.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="66360" checksum="8C93DAEA4D6CC21F" modified="2020-12-02" version="1">MFQDEILAPETKHRGIFINDDDNESDHKGKPLHTTTVIIRQYNKDDKHANYEAEDTLPMAGSEEFDEYGNRKMAPPLISMNEADNLLGVDKTLLDNAAIHNVLYNPSMANSYPEQKEGNMGQQNGLAGEADDFSNALKNQDDQPNSLHKTAAKQAEGIPQHTPSPMTSGDRFGSLHRPKVPIMGNGHQESVKPQGHVVSNYGGNQMGMEKHKNYMDEMGDMPMGENMGEMNQMQGMGGGMQDMPGIAEGMQGMAGMGGGVQGMAGMGGGVQGMGGMGGGVQGMTGMGGGAQGMAVMGGGMKAMGGTGKGSGPMGMQVLGGSQDEINSNMNNALAGMQDMAMKQIQSKYPGMPITMXADDGGDESGEEPTVSVQQESGDNQEAGSASSEVSPSSQPTNSEVFGKHQESKTNSEEKSEGKGKKISNKKAEEKEQQSADTNIKKPGNNNVVNDQKSKGHDGVKESQKSEDHLMNDATNKEKGGNDEPVSSQNGENTKTATGGQKQSAKSADQKANQNDQQTVSKEQTTAKLEPKEVCKQRASGVYTSSHDPSKFIICYNGITEERQCAGGMVFNPREKVCEAIGKQNDNTLQDKPSKEKIKNQKMKKSQKQRKASGKKSSSREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J526</accession>
    <name>A0A6P8J526_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031574767.1">
        <property type="nucleotide sequence ID" value="XM_031718907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308480"/>
    <dbReference type="KEGG" id="aten:116308480"/>
    <dbReference type="InParanoid" id="A0A6P8J526"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000097">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028507216" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="60"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574767.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29985" checksum="05385026366D15F1" modified="2020-12-02" version="1">MARILXIVALMVACXMAKPAAKEQAQPGYELFEGDMMFTKDEIKAAEEGRDPSQDGGARSLIKNRRWPNGVVPYVLDKSVKNKFLNALGIKGPTERAIYSAIKEWEQKTCIRFVPRTNQKNYIEFFSGEGCWSYVGCLGHGKQXISLGSFCFTHGIAVHEIGHALGFYHEQSRPDRDNYVEIVWDNIKEKNKHNFKKYGHGTIDSLGVPYDYGSIMHYGKRDFAKWPWQTTIKVKKSGASIGQRSHLSPLDVKQMNMFYNCNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1D8RAI9</accession>
    <name>A0A1D8RAI9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ficolin-1-like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ficolin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FL1</name>
        <name evidence="10" type="synonym">LOC116295239</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="van der Burg C.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Insights into the innate immunome of actiniarians using a comparative genomic approach.</title>
            <authorList>
                <person name="van der Burg C."/>
                <person name="Prentis P.J."/>
                <person name="Pavasovic A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KX592607">
        <property type="protein sequence ID" value="AOW69398.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558870.1">
        <property type="nucleotide sequence ID" value="XM_031703010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1D8RAI9"/>
    <dbReference type="KEGG" id="aten:116295239"/>
    <dbReference type="OrthoDB" id="7972392at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF459">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="223"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="7">
        <location>
            <begin position="302"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AOW69398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558870.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="57579" checksum="29133B62F6F9115A" modified="2017-01-18" version="1">MADSKRSPWPSSSMIVTMIFVLLCLGEFIRVELLLKDHMSKIRELESKLQANRHHNNEGTKSQQKQNVKLTKPESSRVRVRRNASDSQLTDLIKLQQLHASVCNITITDMKCRAGPPGPPGRPGRRGERGLKGDKGIPGKLGYRGNMGPPGPRGDKGERGEKGGLGIPGLHGNNGIMGPPGRRGQKGEKGEIGRKGKRGEKGEQGPKGTLVSNVNPGLTVSSPHVIVFPPTMVINENQTAIFNCLVHGYPEPVIGWSKVEERNSSQLSNNRRLVIPNARPSDTGTYRCQAKNVLGTKQKTVYLAVNDFKDCSEIYKSGERRSGVYVVNPDGRGRPFQVYCDMTTDGGGWTVFQRRQDGSVDFYRDWNEYKTGFGNLHGEFWLGNDKIHRLTSRTASMLRVDLEDWNGVKVYAKYGSFSVGSEGSNYRLSVTSYSGSAGDSLAPDHNGMSFTTIDRDNDESRFTNCASSYTGAWWYESCYSSNLNGQYLGNVLSLKGVVWYEFKNEFLSLKFTEMKLKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GXK8</accession>
    <name>A0A6P8GXK8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116286587</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116286587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549004.1">
        <property type="nucleotide sequence ID" value="XM_031693144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GXK8"/>
    <dbReference type="GeneID" id="116286587"/>
    <dbReference type="KEGG" id="aten:116286587"/>
    <dbReference type="InParanoid" id="A0A6P8GXK8"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031549004.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="72537" checksum="FE37E864FF20D175" modified="2020-12-02" version="1">MYTAKNAVVESPYHFLTTNLIPGTERRLVHGKGAVVTDDRGKPYIDLSSSTLNMSFGHQDPHITGAVKEQMDKVWFVASAFNNPAFIELSRLLVEVAPEGISSVNVRSCNGSDAVENAIKIARSHTRRKKLLCARHAWHGESISTLGLSSMHAYYRVGYLPDVFHAEEESLESLIELIKMHPDAAAVVLDPLGVASGMYDPTTLKQNLYDIRELCSKSGIVMVFDEIQTFGGYMGDSLFASGRYGVTPDIICIGKALGAGIPISAILCQGFLRGVLLAKEGELTYGGQPLGCVAAAAVINAFKAKRKHVSTNLAHFEEAARKLRSDFQNSDLRIRQNGFFLTVTRKDGKFAGNWMKVVSKKCLEQGLLVRKNQGKSILIKPPVIIPSDVIDECFDKFAAILKEVEIEFQKPSILYSELTENGEKPSLTTRIRNTPPDNKCKYIEALLAEVNHSLSVRKADAGEQEVNVKLLRRAGIPAAEVYKSTDGSLEYIYQPGVPMDKFMASNPNDLPVINGLVLLHQRYVEMAHDAGLSVPDRCPGNAIVSGVSIAALMDFDLVYKTSDDDQDLLFAFEEVFSTFQCVAWIKDASLQQDLSNRLCFAVMDRYGALVPHIWSGMTKYYSSPSRQESLTRHDCMRAIEAMSRSFSNLQCGIKNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZ46</accession>
    <name>A0A6P8GZ46_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116287021</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549489.1">
        <property type="nucleotide sequence ID" value="XM_031693629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZ46"/>
    <dbReference type="FunCoup" id="A0A6P8GZ46">
        <property type="interactions" value="3092"/>
    </dbReference>
    <dbReference type="GeneID" id="116287021"/>
    <dbReference type="KEGG" id="aten:116287021"/>
    <dbReference type="InParanoid" id="A0A6P8GZ46"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000058">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000429">
        <property type="entry name" value="Pre-mRNA-processing factor 6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003529">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="14">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of forked" evidence="13">
        <location>
            <begin position="331"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031549489.1"/>
        </source>
    </evidence>
    <sequence length="930" mass="105167" checksum="6D3A22C7A01946AA" modified="2020-12-02" version="1">MSLLNKKRKPFIGVSAPLGYVPGLGRGATGFTTRSDIGPAREATDISDERHGKPAHLQKKDDEDEEEDLNESNYDEFAGYGGSLFSSGPYDKDDEEADEVYEAIDKRMDDRRKERREQKLKEKIEKYRQERPKIQQQFADLKRKLTEVSEDDWVNIPEVGDYRSKKQRNPKGEKFTPVPDSVLQGAVLSGNTVSALASRQQKYAGFQTPFPGAMTPGFSTPSADLDLNMIGEARKSLVGVKLDQASDSVSGQTVVDPKGYLTDLQSLTPLSGGDIGDIKKARLLLKSVITTNPQHAPGWIAAARLEEVTGRMQAARNIIIKGTDVCPKNEDIWLEAVRLQPPESSKQVAAQAVRHLPQSVRLWIKAAELETETIAQKRVYRKALENIPNSVRIWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYESARKVLNKARESIPTDRLIWITAAKLEEANDNKPMVEKIIERAIASLKSNGVEINRDQWILDAELCEKASSVHTCQAIIRSVIGVGVEEEDRKHTWMEDADSCVAHNAYECARAIYAHALTVFPSKKSVWLRAAYFEKNYGTRESLEALLQNAVKHCPKAEVLWLMGAKSKWMASDIPAARSILALAFQANPNSEEIWLAAVKLESENNEDQRARKLLQRARMNACTARVMMKSIRLEWVLGNIPEASKLLEEAVQKYPDFPKLWMMKGQIQQQKGNQEEAREAYKLGVKKCPHSIPLWLLWARLEEKMGHTTKARSVLEQGRQKNPKCPELWLEAVRVEVRGGNKDFSKTLMAKALQECPTSGIIWSEAIFMDPRPQRKTRSVDALKRCEHDPHVLLAVAKLFWSERKVSKARDWFNRAVKLDPDFGDAWAYFYRFEQQHGTEAQLEAVIHKCSQAEPRHGELWCAESKAIPNWRLKTKDILPLVVKSLKPIDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H0U7</accession>
    <name>A0A6P8H0U7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein Rab-33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549303.1">
        <property type="nucleotide sequence ID" value="XM_031693443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H0U7"/>
    <dbReference type="FunCoup" id="A0A6P8H0U7">
        <property type="interactions" value="1568"/>
    </dbReference>
    <dbReference type="GeneID" id="116286858"/>
    <dbReference type="KEGG" id="aten:116286858"/>
    <dbReference type="InParanoid" id="A0A6P8H0U7"/>
    <dbReference type="OrthoDB" id="10006973at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002685">
        <property type="entry name" value="RAB33A, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549303.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28341" checksum="0F2CBC0C5D8747B8" modified="2020-12-02" version="1">MKSSFYDREDEVLDNEESKPPITEKTFKIIIIGDSNVGKTCLAHRFCTGRFPNRTETTIGVDFWEKQIQIGSDTVKMQLWDTAGQERFRKSMVSHYYRNVSAVVFMYDITRKSSFEGMSNWLYEYGQFSEAPDVPRILIGNKCDLGNLRTVNSNEARKFADSYNMPLWEISTKNNEELETIDSIFLTLAHKLVKDKPIMKRGEGLAEIISADGGKTSKRHSSKKRSKRIKLQGKEKQDKKKCCESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H599</accession>
    <name>A0A6P8H599_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RNA-binding protein FUS-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116288841</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM TET family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551544.1">
        <property type="nucleotide sequence ID" value="XM_031695684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H599"/>
    <dbReference type="GeneID" id="116288841"/>
    <dbReference type="KEGG" id="aten:116288841"/>
    <dbReference type="InParanoid" id="A0A6P8H599"/>
    <dbReference type="OrthoDB" id="76445at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="425" mass="42568" checksum="E99D46164C7AEDFF" modified="2020-12-02" version="1">MSDQGYSSGYGQRGGAYGGSASTGYSSQSYGQGYQQDTQGYQSSGYGAAAQQNTYMQGSTSNTSQSSYQDGGSSYQSGGYSSAPTASSGSGGYQPPSQSSYYQTPSSNYQQSSQSSYGSQGAAGGGGTSGYGSSDRSGGYSSASRYSGGGGGGGGYGGGGSSGGGYRGGGRGGGRQDRGGGYSNGSGYGGSDSGGPQEKQYSQDTIFVSNVNKDANEEDLKNLFGAIGIIKYDKKNDRPKIWIYKHPDGVSKGECTITYDDPPTATAAIEWFNGKEFMGQNIKVELAEARTPKFFQRGGGRGGGRGGGRGGGDRGYGGGRGSRGGGGDRGGGDGRSGDWDCPSCGNMNFARRDTCNRCHESRPGDAGGGSSGGYGGGRGRGGGGRGGGGRGGGGYGGGRGGGRGGGGGRGFDRQGARQDRRDRPY</sequence>
</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5H8</accession>
    <name>A0A6P8H5H8_ACTTE</name>
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        <name evidence="8" type="primary">LOC116288115</name>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5H8"/>
    <dbReference type="GeneID" id="116288115"/>
    <dbReference type="KEGG" id="aten:116288115"/>
    <dbReference type="InParanoid" id="A0A6P8H5H8"/>
    <dbReference type="OrthoDB" id="5989152at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028148627" evidence="5">
        <location>
            <begin position="27"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="57"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="171"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550716.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34790" checksum="DC4114A0936A9EE3" modified="2020-12-02" version="1">MVLKNRVVFYSFLVCCSLIRPSSVDALRRTRRDDLKNEHYTCSHQGKLDKNHPTGAPTITTDCNSFMEYYIDDNVYVTCQVKSNPVAKITWLFNGKPAQHKLDITSCSQKLHIPYAEVAHSGAYTCIASNRYGTVNETCQVTIQARKRTFFIINKGILINGDPRSSKAVIGSPLNMTCEIYNAHYVYWTKNGVHFPPSRPLNSRNSNLRISKYKKQMGQTMFILHLVFARVVEEDRGNYSCAGRDNLIGDTVHSYKYLEPIFAPLPAGRQASSSPSMSALPSAVYLVLAHLVLHLSNFPAKTQAYAFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H5Y2</accession>
    <name>A0A6P8H5Y2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116288242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550871.1">
        <property type="nucleotide sequence ID" value="XM_031695011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H5Y2"/>
    <dbReference type="GeneID" id="116288242"/>
    <dbReference type="KEGG" id="aten:116288242"/>
    <dbReference type="InParanoid" id="A0A6P8H5Y2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="97"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="375"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="684"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031550871.1"/>
        </source>
    </evidence>
    <sequence length="923" mass="103083" checksum="D8FA97D464945D4F" modified="2020-12-02" version="1">MGGKYQRLASETGSKTLKKGIFSYLFFTWLNGLLKLDIFWKRIEEFLCNRPALIKTSRSAIIYSKDTQPCKIGSLTFTKNIDSTRATCIELDTEPRVNIIEMSASWTSQQKSVLHQVSMVVQSNQLLIVTGPVGSGKSSLLMAILGEIPTTEGEITLHGRTAYVSQIPWIFSASIRDNIVFGRPFDESRYKRILEMCDLEKDINCFPHEDLTIIGQRGVGLSGGQRARLSLARAVYSEADIFLLDDPLSAVDARVGQHIFDKCICGELSNRVRVLATHQVQYLPRADKIAVVREGAVVLGTYSELSENGIVDTLQKRHEDTTSDYTLLEDVNHYDYDNSKDMREEDEDRATGTVSWRLYWRFFKAGLPPVIIGCLALFYIIAQASSVVPTWWMSRIVHMTLQEQRGSFSLSVFGGLVGASLILFLVKDLAFVSAILRSTRKLHDKMTLAVIKSPVLFFDTNPAGRIMNRFSKDIGAMDDLLPIQFLYSVPMCLNIVIVILLALVVSLWIAVAVIPMAMLLFLIAAYYLKSSRELKRIEAIRCSPVYDHVAETITGLEVIRTSGAEEECCNKLLRLQDEHTKAFFLVMATSRWLGLYVDLLCAFFLVGVAIVGLVAIHDHGLAGMLLSLSITLFGTTQYGIRQATDVVSQMTSVERVMTYTELPSEPGYTRQDKSSDDWPSQGSLSIRDLSMVYLEGGPSVLKDINLDVQPKEKIGIVGRTGAGKSSLVAALFRMPDPQGQVFIDGVDLGTIDIQVVRRSMAVITQDPVLFAGSLRKNLDPFNRFTDQAIWTALDEVQLMKKVSKLHHQLDYCVGEGGSGFSVGERQLLCLARALLQNCKILVLDEATANVDYKTDHLIQQVIRQKFTKCTVLTIAHRVNTIMDYDKVVVLDHGHVMEYDNPRVLAGKENGYFSRLIKGHTMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H624</accession>
    <name>A0A6P8H624_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550863.1">
        <property type="nucleotide sequence ID" value="XM_031695003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H624"/>
    <dbReference type="FunCoup" id="A0A6P8H624">
        <property type="interactions" value="1590"/>
    </dbReference>
    <dbReference type="GeneID" id="116288237"/>
    <dbReference type="KEGG" id="aten:116288237"/>
    <dbReference type="InParanoid" id="A0A6P8H624"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550863.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45801" checksum="4599E5A7D3991794" modified="2020-12-02" version="1">MAVSLNSSAEGPAFSDSDMSADEGSTTTTNQNVGLISLLKQENRVLKMELETCKLRCKSLQEENRALRQASVSIQARAEQEEEFISNTLLKKIQLLKKEKETLATNYEQEEEFLTNDLSRKLAQLRQEKIQLEQTLEQEQEYQVNKLMRRIDRLESDVLAKQATLEQLRREKVDLENTLEQEQELLVNRLWKRMDRLEAEKRMLQEKLEEPISEPPSPRQFTESGDAVGGIATHITSLREEIRRLRLQLAKSEADYCEKMQAYAKEERQTKEENIRLQRKLLREMERREALSRQLSESESSLEMDDERHFNEMTSHGQANTSGSAHRERTISSPVPLSTGRPISPGYGFTPPSPHMSRYSSTGSLSSSLPPAGSSPPTHHIIHHRHPSPAGSSNLPRPSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6W5</accession>
    <name>A0A6P8H6W5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-aminobutyric acid type B receptor subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116288562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551226.1">
        <property type="nucleotide sequence ID" value="XM_031695366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6W5"/>
    <dbReference type="GeneID" id="116288562"/>
    <dbReference type="KEGG" id="aten:116288562"/>
    <dbReference type="InParanoid" id="A0A6P8H6W5"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="233"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031551226.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="69647" checksum="6FCC7C43E6DF6260" modified="2020-12-02" version="1">MRIIESFEDYTDPVDNVINEMLLPTLFGQNEPLPEELSRLFTLSPAEGGLGMPALKEEAPQQYAASLLITASHTEAIKTQSKTMYTTTEDTSTEYWNLILSTNPSPGPASPFAFDTVWTTALVMDKALKDGLALDNFTYTSRIHMRAFRTAIRELVFEGVSGTIRFDSKRERQGHVVIKQMRNASWVEVGQHFTYQDKLEFFGSSEEHLWPGNRVPIDQMIRIDDLLLNPVTLIAVIWLLAFVGALLSIVFLYFNIVYRENRSIKMSSPQLNNVIILGCLLCYISVILFGLDGRFLSLHSYGINCNARTAVLSIGFSLAFGAMFSKTWRVHKIFTAAKTLKKMAIKDIHLFGIVAALVVIDVIFLSLWFAYDPLQAHKLKFNLMETTNNDKIYVPVLYQCTCQYKTYFLATMYVYKGILLLFGLFLAWETRNVTIAALNDSKYIGMSVYNVVTLSCIGAIVTTALDNTIHYEAPYAISSLCLIICTTATLLLVFVPKVYNFVMGTDDQSFNTATMTNGVATTIGRNQSHAFRFDSDNGTKATRYSTKSVQTDHHEVTGSAVTETFMLDNTKDYDNVNINKGYEIDMDDIELKDSSLIPKTRYDQQVTDNGLVTLMLTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7T1</accession>
    <name>A0A6P8H7T1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="19">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116289672</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="19">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="19"/>
    <dbReference type="RefSeq" id="XP_031552484.1">
        <property type="nucleotide sequence ID" value="XM_031696624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H7T1"/>
    <dbReference type="FunCoup" id="A0A6P8H7T1">
        <property type="interactions" value="3128"/>
    </dbReference>
    <dbReference type="GeneID" id="116289672"/>
    <dbReference type="KEGG" id="aten:116289672"/>
    <dbReference type="InParanoid" id="A0A6P8H7T1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000373">
        <property type="entry name" value="Mitogen-activated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008349">
        <property type="entry name" value="MAPK_ERK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01770">
        <property type="entry name" value="ERK1ERK2MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031552484.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41570" checksum="D41460F298724E42" modified="2020-12-02" version="1">MAGITDTRAPPEVVRGQQFDVGPRYSNLNYIGEGAYGMVCSALDNQTGQRVAIKKISPFEHQTYCQRTLREIKILRRFKHENIIGILDIIRAPTIEDMKDVYIVQSLMETDMYKLLKSQKLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCILGEMLSNRPIFPGKHYLDQLNLILNILGSPSEDDLQCIKNDKARSYLESLPFKPKVPWTRVFNNANPKALDLIDKMLTFNPNTRITIEESLAHPYLEQYYDPGDEPIAEEPFRFETELDDLPKESLKELIFQETSHYPSSGASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8C4</accession>
    <name>A0A6P8H8C4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Jouberin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116288793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551493.1">
        <property type="nucleotide sequence ID" value="XM_031695633.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H8C4">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="GeneID" id="116288793"/>
    <dbReference type="KEGG" id="aten:116288793"/>
    <dbReference type="InParanoid" id="A0A6P8H8C4"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052803">
        <property type="entry name" value="Cilium-Associated_Jouberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44499">
        <property type="entry name" value="JOUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44499:SF1">
        <property type="entry name" value="JOUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
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    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
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    <dbReference type="SUPFAM" id="SSF50978">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="551"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
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            <begin position="1070"/>
            <end position="1130"/>
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            <begin position="17"/>
            <end position="35"/>
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            <begin position="199"/>
            <end position="209"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031551493.1"/>
        </source>
    </evidence>
    <sequence length="1211" mass="136522" checksum="FC82CDC46CBB1D57" modified="2020-12-02" version="1">MDPGSAKKKKHRRSKSNLQTQAEIAGSTDQLLSGDNESKVLKARQRTKARFESFLQDAVSENSIQSSGKKKKKKRTHTADSVLETIRTGSPIAKTPSKSEESLIQANLYKEDHTTPGKESKASYRSLMQEKDNNVLSSQEITPKKSKSRRAKSSQNGELSVTPGENDQSKRRKKTRTPGKLAFNEDSGKENLAFEDEDQKLVDETEASKASKSPKRRGERVKRKLHHDGEKSRKRTNDGFIFSVTIHRADRLKPDLQISHPMVRVHVVDSETGNYVKKSSEXRNVTSFYESKHDTPVDYIMPVMTQPFDFKTHKCVVPSWEEVLIFNESYSYFLSLKDADPKVIIFFEVVDFLSMTASNRQHESEKGWYRIAWAFLKVVGGNGTVNADRKVRLQLFYPYRSAFRNKNPGHLEVYHWWKQSQRVPYPSTLYVTLKGVQPPKKLDPALRSMYAIQQEKGRVTFEELTTDAERRAYGLTDNKDNEDQPPNWTRLPGQVNRIPNKQMLSLRSGKRGCFVVKFSHNGRYLACGCADMDSFPVIVYEIPSGNCRGELLGHFSIIYDLCWSADDSELISSSSDGTVRMWDTKTMMTSFIKVFPHPCFVYSAQFHPSSPYIIVTGGYDRLIRVWTSACEGINGQLVREIDGHNGFINSICFGQQGNKMFSADSAGSIIMWQTSIDPASNVKRKKKNPLDHVRNWMTIKHLKEEELQGNVINSLEIHPGGLKLLVHTRNSALYMIDLRSFTIMTRYLGASNFKEHIHSTLSACGSFVFSGSEDGVAYVWNTETGDIVSVYTSLTYENAVSDVDFHPLDHIIVFCSFGNSQPVLVYKYDAKAAKVEAKRMFTPPTMPIKVATPVAAETSQEESTRHLGDVTQDVIRMQRVKNKLDSVLDTPGSSRVLDTAILKTPGHNASYPFQTPTMYQSEASSTMYPSPQPGQVTFQLPDSTMRTFRQGMGTHDTMSTWGSDFSPTGYGTTPVQVPGYAMSPHSQQHLGSSGRFQSRQLYSQMAGSPVDTPGSPVFRNYPGRDQYSRQGSLSMNLSRDSPGPMRISHLKQKPTFSFNAGEPRGDRRSXAMKRVLVMYPYEANRADELTIQPGDVIAVLYQDNENWWMGELADGRQGYFPSNYVMQQDEMESDNDIQEAVKRSSSKHRKTKDTKMTAVTSKTGELKIISGPEDSSDAELSASQSIARQRRRHRQSATPEKKAPKKKQSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8C6</accession>
    <name>A0A6P8H8C6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116289894</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116289894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552694.1">
        <property type="nucleotide sequence ID" value="XM_031696834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8C6"/>
    <dbReference type="GeneID" id="116289894"/>
    <dbReference type="KEGG" id="aten:116289894"/>
    <dbReference type="InParanoid" id="A0A6P8H8C6"/>
    <dbReference type="OrthoDB" id="5983599at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027626933" evidence="1">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552694.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23653" checksum="511CCAF334954C73" modified="2020-12-02" version="1">MRRAVVLGLALLTLLIVTVSGMQSNIEFTKRCIEQYKSVLAHYNDEKGTCTRLQIFMDCLSNKPDERGQLLDAMRYFFTQQAIFVSKLNYCPKIDYKTIKAIASHTDFAKNHNYLDSIGDEEAWDTCAIDVHKYCVKKYVTLFAKERKICDDVNSWIDCYSEEARNIGCDAEILTHFSKMLSIVGKLVIREIRRFAGMECVKMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8V6</accession>
    <name>A0A6P8H8V6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SURP and G-patch domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116289213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551956.1">
        <property type="nucleotide sequence ID" value="XM_031696096.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289213"/>
    <dbReference type="InParanoid" id="A0A6P8H8V6"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040169">
        <property type="entry name" value="SUGP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340">
        <property type="entry name" value="ARGININE/SERINE RICH SPLICING FACTOR SF4/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23340:SF0">
        <property type="entry name" value="SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="357"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="240"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551956.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48570" checksum="46DF0050CE6FF4BE" modified="2020-12-02" version="1">MASGGGWSSNQXTIEDKKRELLRRIEEKKKXSTGSNPPCPSTNAYDSNTPTTNXPPSLFVNDGSFXARFQAMQKSKAASSPNTTTALPKPSVTMKISTMKKSSVTRPLLKRNDVFEREDDDTQNVSPPEVKLSSQYLSASTSTGASSSNFNSSGSFXQSLPGQNSESNPTAAKRKRKSRWDDSASQVSTPPSSSALKGLENPMSEAAKIAARIGAEVAMEHSIPMSSHEAEEREKQRKEQEEITSVYFRILAKRAVAAAAAKSAAQTKETKPKYEYDSDEETEDGGTWEHKKRREEMSKTIDEAKKLTEQAKGKHHIGDFLPPDELKKFIAKVKLVKGEKGLDEIDLSDYAEFKLTEENVGYQMLKKAGWSEGKGLGSKEQGITAPINKTHTPTGAGLGEEHVAEVKSDDDEFDLYRKRMMLAYKFRPNPLNNPRRPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H924</accession>
    <name>A0A6P8H924_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Far upstream element-binding protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116290080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552924.1">
        <property type="nucleotide sequence ID" value="XM_031697064.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H924">
        <property type="interactions" value="4583"/>
    </dbReference>
    <dbReference type="GeneID" id="116290080"/>
    <dbReference type="KEGG" id="aten:116290080"/>
    <dbReference type="InParanoid" id="A0A6P8H924"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="KH-I_FUBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22397">
        <property type="entry name" value="KH-I_FUBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22398">
        <property type="entry name" value="KH-I_FUBP_rpt3"/>
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    </dbReference>
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        <property type="entry name" value="KH-I_FUBP_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
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            <begin position="201"/>
            <end position="273"/>
        </location>
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    <feature type="domain" description="K Homology" evidence="4">
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            <begin position="300"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="391"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
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            <begin position="618"/>
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        <location>
            <begin position="41"/>
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            <begin position="59"/>
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            <begin position="379"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="3">
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            <begin position="466"/>
            <end position="479"/>
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            <begin position="618"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031552924.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="71258" checksum="7E4D2D1F10E824DD" modified="2020-12-02" version="1">MADGVAYQSVPPPSGSSEASTAFADALKRAKEIAARMGTAPQGSDGSSNVPYQETPADQVRKRPYSDEGEEPQPKKMLSEGGMPLMDGKDPKSIALQVAASIAQRAGLGSMLTEELKIPNKFVGLVIGRGGEQINKLQSETGARIQVAPDPPMGIMPPPDRAVTISGSXQAVDKAKALLHRICEEGKIPDSLMSVPVVAPGETVCEMMIPASKVGLIIGKGGETIKNLQERAQCRMVMIQDGPYSNAPEKPLRIMGDPTRCQRGKDLVTDLLTEKELEQIKPPVDIHGRRPHQETGYGGGGEVLEIPVPRDIVGFVIGKGGETIKRIQAESGARVQFSPESDNPQSPDRIATVQGTQEQIQHVESTIKDIIQQSRQRGGPPPKGPPPNMPGVKTVEAPVPGNKCGLIIGKGGETIRQIMQQSGAHVELNRNVPESSPTKYFVIRGTDAQIQQAQNLIREKVEDTRGGGSGRGRGGGNYGGNQKWNQNQNSNWNQQQQQQQQQPHQQQSWSGGGGNSNNYPYGNQQQYGQQDYSQQQYGQQQFEQPGQQVAQQGQQGAQGGQQDYAAAWAAYYQQYYQQQAAAAAAAGGQAPGQQPQAGGQPDYTAAWNQYFKAQQNYYQYPYQQGQQPGQPGQPGQHGQPGQPGQQQPQQPQGGPGGQPPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H969</accession>
    <name>A0A6P8H969_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">5-hydroxytryptamine receptor 1F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116286857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549302.1">
        <property type="nucleotide sequence ID" value="XM_031693442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H969"/>
    <dbReference type="GeneID" id="116286857"/>
    <dbReference type="KEGG" id="aten:116286857"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
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            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="35"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031549302.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47465" checksum="2A3308B33ACABD82" modified="2020-12-02" version="1">MLNVTRNTVTSSWGAEKLTVFILFLSVIDGLAILGNTLVILVILWTKSLRRMEANSFVMSLSIADLLVALTIVPITIASLVNPQNHPYDKFKTFLGVGNFFFCICSIMNLTLLSLDRYFAITSPYRYLDFLTHKRACSLCILIWVYSLGFSLPPVFGISSYSCFIPNFETCREDVWRSSDTLVFALLVLGFTYGLSLVSMSYCYWKIFKVARSHSRRIAAQQSFRISVKTKNQFVEQNARTTQNLALEVSKAEEIKSQSIQSHQNGQINGNDTETAGFRWVEKSLIDIVIAPWIIGPKRPINTKNPDFEHSLHSSADSDGSSKNSDKNFTKNEMRVARSFLIVIGLYVLCWTPFCLILALEIFLRRKLSEEASLICLWIGYTNSCVNPFIYTWKYRQFRCALIRLWRNCKLLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBJ4</accession>
    <name>A0A6P8HBJ4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 205-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552991.1">
        <property type="nucleotide sequence ID" value="XM_031697131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBJ4"/>
    <dbReference type="FunCoup" id="A0A6P8HBJ4">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="GeneID" id="116290136"/>
    <dbReference type="KEGG" id="aten:116290136"/>
    <dbReference type="InParanoid" id="A0A6P8HBJ4"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="85"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031552991.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28983" checksum="5E00B9CB8601A84B" modified="2020-12-02" version="1">MAHSQPIKDVVRWTFQHQYFQQTVKNKLKNKKAAATKTKNMTSLFGQKVFCCVLVLVMACFSDKVKLLFQKGTINQTIQVYLHSLAISSWIGIQAWVIFVAGITMYFNMPRHVFGHIQSKLWPMYFRIGTSLTVIALLTNGAVLQLKEKKTRIEEFQHVSGLLVSLLCGILNSFYFEPNATRLWMDRFAFEKERGFGNEIGPIKDKELLANPKYKALTHKFAMFHGMSSLATVFSFIGGLVYLWNLTCHLINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCL3</accession>
    <name>A0A6P8HCL3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centromere protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners. MHF heterodimers can assemble to form tetrameric structures. MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex. Forms a discrete complex with FANCM and CENPX, called FANCM-MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling. Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554179.1">
        <property type="nucleotide sequence ID" value="XM_031698319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCL3"/>
    <dbReference type="FunCoup" id="A0A6P8HCL3">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="GeneID" id="116291190"/>
    <dbReference type="KEGG" id="aten:116291190"/>
    <dbReference type="InParanoid" id="A0A6P8HCL3"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554179.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8720" checksum="B13BE0209A03D01B" modified="2020-12-02" version="1">MESKAAFKPGTINKLLQQSFQDQQKTKVNGDALKLMSEMLRTFVAEAAARAGKQAKAESASTVQTEHLEKILPQLLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEU8</accession>
    <name>A0A6P8HEU8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554266.1">
        <property type="nucleotide sequence ID" value="XM_031698406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291255"/>
    <dbReference type="KEGG" id="aten:116291255"/>
    <dbReference type="InParanoid" id="A0A6P8HEU8"/>
    <dbReference type="OrthoDB" id="5968104at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554266.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23817" checksum="FAEFB41242DF76A1" modified="2020-12-02" version="1">MSSTEEKGKLLAGTNRSDTTMVGQVEATRIQMEETGVTVTLRDEVHAQTNHYIKQSRPYFPNTKLHTYIDCPYFLHLARLLFFASLFGALVATTIGIPKELPMSFFVACAVFFLIYCQHEWVNQKSLXVVQKQPVFDDQQATNSFYELTVTELKGLALENYQAGIGFVKLTQGKIEFQAFNKTAVKRMSSAKCQSRLMLVLFFLSSVYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFU5</accession>
    <name>A0A6P8HFU5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116288768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551455.1">
        <property type="nucleotide sequence ID" value="XM_031695595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFU5"/>
    <dbReference type="GeneID" id="116288768"/>
    <dbReference type="KEGG" id="aten:116288768"/>
    <dbReference type="InParanoid" id="A0A6P8HFU5"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="208"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031551455.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52198" checksum="8E92F620DEB3160E" modified="2020-12-02" version="1">MLLLCLCLMDHFKESREKTAWGGSIAGGLVFFCVPLSTMVMTRLKIRFSAILGILMCITSLVATSFTTNIIQLFFSYSILYGLGMSLVFTSCIFASTKYFDKRQAIAIGIVTGGTNIGVLSLGPIVQLLIDLYGFRTMYRIMAGSFVLPLLAVCSFDPNVEDPVDKEKQFRENEDPVDEEREHRGNEDQPGDHEWNWSMVLEIFKRPMYVVALIVFTLQAMTAFISFVHLVNYCREVGISVQKASNLFIAIGVSSMIAGIIAGRVMDYKRVNPFHVNQAGALSMGIATTLLQLSSNYIFFIFFSIFLGFGTGVFSTTIVVLLLRTVEPRLRIYSFPIGQMISAIGNFTGPPLIGFIADTVGSYKPAFYTAGAILLLSFFLPFLQYYFKPWRTLEMEEQPTQIETNESPDHRDILDDRQTVDEEERVAGLEMKDKGYTQDGTNIPSNVNLAVEEDCVTIHENISATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH20</accession>
    <name>A0A6P8HH20_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Poly(A) RNA polymerase GLD2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116289150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551887.1">
        <property type="nucleotide sequence ID" value="XM_031696027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HH20"/>
    <dbReference type="FunCoup" id="A0A6P8HH20">
        <property type="interactions" value="1636"/>
    </dbReference>
    <dbReference type="GeneID" id="116289150"/>
    <dbReference type="KEGG" id="aten:116289150"/>
    <dbReference type="InParanoid" id="A0A6P8HH20"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="11">
        <location>
            <begin position="334"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="10">
        <location>
            <begin position="565"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031551887.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="73782" checksum="A407D4602B35756E" modified="2020-12-02" version="1">MTSRHNSVDNSSSSNSGILEKLASIPLLCNVLETQMYNESYAQRSGNPQRYNSTENVSNTHSQQQQNYLNSINKSTYEMFHSSKDITRQKHERPYRRQSLPTPAYHSSSNGMPLQRFQAGHSVGPSKSYALSSERNFRRHSNSPIYPLNKLYDAHDLRNVADRKPNVISNLDLESTPEQLLNHHSTMTSSTHILAHESLSETRNAVEKAVSAEVIDLTEADLEPRSSVSSSSQTAAKSRNDSKSEDSDSVFDMDKGTEQTKAKLRVTGLKRPRYSELTGFNDNAHSFANKKMRRASGPDRFASHTSSSTYSRPRENSRSTSPYPTDLPFTLKTLTEEIKKESTECLQSSALLAKKQTLRSVLENIFRVQFPGCVLHLVGSSVNGLGNEQSDADFCLMLTQWREIDQRSEARGILLKLNRLLSSCSFVEGNQVIFATVPIIKFVDSVSRCECDININNHVGIRNTFLIKAYCKVDQRVGPLVMVVKTWAKKHGINDSKDGTLSSYALTLMVIHYLQCGCHPAVLPSLQKVYPEFFSENGDINVLLKQDVEKIILDANVTKSPNHQTLGELLLGFFQYYADQFNWDKDIISVRLGRTYDKSLYGKARNKYIYIEEPFDYNNVAKTVYCEEKFNKIKMKISLAANKLKVSPSLKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH44</accession>
    <name>A0A6P8HH44_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116292527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116292527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555729.1">
        <property type="nucleotide sequence ID" value="XM_031699869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292527"/>
    <dbReference type="KEGG" id="aten:116292527"/>
    <dbReference type="InParanoid" id="A0A6P8HH44"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031555729.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16458" checksum="699F44936F6B59D7" modified="2020-12-02" version="1">MFNREVQXQMIRQWKKWSADKCLGKSRRNVQVYAGRHVQEMESPAAFLSPSREWNPFFEYHARPVKLPMKLHEDGGKINSRQGLRNAVSVMSHDSYLTGVREQAVLGGTCSKHVYSKNTMVCVSNRNCYSEGELNHTFEYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HH55</accession>
    <name>A0A6P8HH55_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551895.1">
        <property type="nucleotide sequence ID" value="XM_031696035.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116289155"/>
    <dbReference type="InParanoid" id="A0A6P8HH55"/>
    <dbReference type="OrthoDB" id="5961387at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057945">
        <property type="entry name" value="TPR_ZSWIM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25572">
        <property type="entry name" value="TPR_ZSWIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551895.1"/>
        </source>
    </evidence>
    <sequence length="1457" mass="166824" checksum="F4F0C000E6ACD1D3" modified="2020-12-02" version="1">MFSDDEELYYYTRRDYAYDTDDSGPYYDDDDYYDDYDYYDSDSEARYARRLAEYKIKSEKEKLSKELEDGKNNADNTPKVFQCSSLVNICARYLALNFPFAYLQDRFPPIPDDLQLKVIRFSFPDSEEKIRKYAEFSRSGADINYPSKLCSAGKVKDMMQIGFRLSASVEDKYVTIHFDRGKITSAQCTCDSSSSWCLHVIATALMRIRNADSLDQSKMRLPVSDALNDLSREQLLKFSEYLLYHHQNQKIVETAQGLIDKLVNRHGDYSEDQINVVDGAPDPTAGPGIDEECHWFVCTTGFKENCSNLIYEPADNLGFAPLENKDDNTLLHELWYRNRCNYPLVQDDIDTEVGSEFYCPYSLERRQDSSRILETVLELLKDDSMSGLIAIKSCTEQVLSRLEKKGSPYESRRLRSSTLQEVNKPLYPCGSPAMGFTARPFRCWTLCDELSVLWQLAVLNPKMNLKEKQQVSLELMKWSEEAATGCYIEKLKPWKGLEVAYNLCQYIDWHQPHMQAILQDKIPSNYAINGCTLVHINAERTTVKKYPSITCHLPYSFYYGSITLDIHTWCSIINALQVHNYRKPAVHIAFGLALGFISLFRNNIETRTRFSNIPVLNSCTLDHNSKRSEKIAEEDGVEGMDIDDEKPGISCAEIWPADTLLSLRCFAFLCEFLSRNDDEVESLITSHKGLGPENSDLATSLSKISSANSLRFQTAAIGLFLPRFPMAVMRQEAEQYDLENWLSSQLLESKPTPDDMGFLNHLCTVALKDGSHWPLSPPCSFTRITLHHCFKDSNSSAVAVSNPLQNKALILELAFQVLDFTQVVDSHGWTLFEFSTAVSWSKLAELSLSCLAGFTSYTERAMTSILKQSGIFGPGKHNHLVKASPEEIRSSRQWIRTTMDGKSKICFALAKALITRLRRSSSKKGSNLTSRIVPLRELFSSTRNKLIDVFPKIESPLAIMALKKCAIRLGAHSVYLEKTSNRSYSHGSAIRWLIECSIECGLWGLRCLINSHSDISDFMQHEEAINLCKSILKKRDDSMISMVKEILLSLLKQAVRTESMDNIRDILVTCRENHRDTSYLLTPWACQHIHDMALCNTVHFESLMFASEQAFKCYNYKLNQITNENQRMKASDGGMGLKRLFNEGREDSDSEEPAKTYIPLNPYITPNKPHPYLELSFKLGLMGLTALTRGNESPLRRYRRSDRDKKERLQEFCEVVCYIATKKWLDMENKQGEGSSKRFSASSSTGSRRGIDESYISRFVTDLLKSVTNPMHLLSFLREMSSRLFPEIDEDTCKAIRAELNTVSKIELAQLRKAINTIPSLLFLIQRIESQFKELLLGPKVTLLVKNITDRRPHSSHKELRPEFEYHDLEEDTLRDTLKAAKEVFELLDSSGESFKELVSAIQKKHEELKPVLEGILLGEEIPRHRDGELFRNPFFFWPFIQELQFGRRHPLEEFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI84</accession>
    <name>A0A6P8HI84_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">JNK1/MAPK8-associated membrane protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116292402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555581.1">
        <property type="nucleotide sequence ID" value="XM_031699721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HI84"/>
    <dbReference type="FunCoup" id="A0A6P8HI84">
        <property type="interactions" value="1869"/>
    </dbReference>
    <dbReference type="GeneID" id="116292402"/>
    <dbReference type="KEGG" id="aten:116292402"/>
    <dbReference type="InParanoid" id="A0A6P8HI84"/>
    <dbReference type="OrthoDB" id="5920264at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028051621" evidence="2">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031555581.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34888" checksum="E3C4FBDBD3406D7F" modified="2020-12-02" version="1">MDGKSSLLLLASAIILLQSTSSGETESCPGRYCGRTIDEASGKISECGACPRGSRSNGTFCNKCTNTLQMYDWSYLGFTFLTALVLHWFFVDYFSKRSQQAIIILFACGAIETTCAAFFTLLLNEPKGTLSLTSCSSEHLSDWYTVFYNPKPDYVNTIHCTNEAVYPLYTIVLTFYAICVAMLLVIRPLMSHYICAGQGLSSIYAGMYFLPILTAIHAILGGLLYYTYPYIILVSSVLSTATVLAKNHITGFRQLLGSKRLVAIMIGHWLLLAYGLLALTQVSKPVVHGPMFFLVTTPVIFYLATSSLTDPSKFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIW3</accession>
    <name>A0A6P8HIW3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="3">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116293070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031556324.1">
        <property type="nucleotide sequence ID" value="XM_031700464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIW3"/>
    <dbReference type="KEGG" id="aten:116293070"/>
    <dbReference type="InParanoid" id="A0A6P8HIW3"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="15">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031556324.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="68635" checksum="6EBF57F83AF726E4" modified="2020-12-02" version="1">MDSNLTDDEILSLFCALYHYWLNSFDYGFLSQKKEIEFKVELRGSRIKSLPKVKNVMRDGDLDNVVYWLFWFLKSKYSYFTDPLRRHKRCSIVMSRLSPKRPNSLALQQSHSDAFVSGHFNKRRLSLTWFDLMPECSWKRVKLNRRIRKSQFIRLALVALVIIVLTAHKLPRTQLQSSRGICSNSSKYKIYVKGKRVCNSERIQSSKYFTYQPPGGGWNNQRIAFENAVIMAKLLNRTLIVHPMAPHQEIVRLKKFYLFDLGHQVYNRVSSKRLLPLSKVIDLSRLSKLLPVKEIFTNHTTFIQDNQHLSWYRVCHNGFQGLWVDSLPSNRNIKAWNALKQRANDMQLHKLKTIPTYRRSCKADMALYSSNANNTPFWGILDELSQRTENIIYFEEGSMFFRQMLFLDKKRTLDAHKWLIKFITFASPIWKRLRNIQSQIGFPFNAMHVRRTDHPTSQHISPDNWLNLLNKRGALNITSKLYVATDEKNLTWFTPFRKAGYDLMFAKDFMEELTPHSNKSNANLLDIIGLTEQLICAHAYHFVGSYYSTFSLYIKRLRKYNSWKGQLLAFPYSPVTWVDIKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ78</accession>
    <name>A0A6P8HJ78_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein KIAA1958-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116291833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554908.1">
        <property type="nucleotide sequence ID" value="XM_031699048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291833"/>
    <dbReference type="KEGG" id="aten:116291833"/>
    <dbReference type="InParanoid" id="A0A6P8HJ78"/>
    <dbReference type="OrthoDB" id="5984499at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="89"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031554908.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21461" checksum="2D8E60A801A9E94B" modified="2020-12-02" version="1">MADEQVLLQXELLSEFILTVRTVEGKNYEPTSLRGMIASFERFLKRKNYQVSIINDLAFEKNRKTLQSKQKELKKRGKGNKPNASVALTEDEXKVLYEKGLLGISSPEALLNSLWLNNTLHFGLRGIQEHHSMCWGDVTLNKTAGGVEYLEYNERQTKTRTGANATDVRPFPPKMFATDGSEKDPVKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJI1</accession>
    <name>A0A6P8HJI1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116293273 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116293273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556539.1">
        <property type="nucleotide sequence ID" value="XM_031700679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293273"/>
    <dbReference type="KEGG" id="aten:116293273"/>
    <dbReference type="InParanoid" id="A0A6P8HJI1"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031556539.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12284" checksum="F4EF76C48E7F1506" modified="2020-12-02" version="1">MEIFNSEQVANFLXNKRVMVIGDSRNRLEELESNLNGGPWDLRSKKNFFFKAYTGLFSVEVNFGLLRCPNTSGRKVQRSMYKDLIRLLVPDPTSTYLTNQHLKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJT4</accession>
    <name>A0A6P8HJT4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 39C-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552947.1">
        <property type="nucleotide sequence ID" value="XM_031697087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJT4"/>
    <dbReference type="FunCoup" id="A0A6P8HJT4">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="GeneID" id="116290100"/>
    <dbReference type="KEGG" id="aten:116290100"/>
    <dbReference type="InParanoid" id="A0A6P8HJT4"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031552947.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="70688" checksum="DB0EC6AE6206B8B0" modified="2020-12-02" version="1">MSSSKGVSRGGSFAGKNTKKSEGFWGYHSLARDGINLLLNNGFEESQKLFKNHSDGNPLMSAGSGMVDFVQAILTFEDDQLDRALENLKKSQRVCYIESSKKSSIAMDERLMRQILYADSELYMALLTFLKQGITDYIKGGYLMRRAWKLYDKCYREISEIGGPFLNWSPEITVQENGASDADAEEVPDLESTEAEEQDMLTVLEEPSSAGTPSLLRKASKEIGSDKLRHLQAAVSCGYGLFHLAISLVPPKLLKFCHLLGFSGNRDVGLQALDIASRSDDMKAPVARLTLLWYHSVIRPFIALDEGNNEEGSLSVGYYYPNASRLTTTSCLLKATQMLEESSQDYPSSAVFLFFRGLVSRLKGNVPLALQEFHQAMHAAAEQTEIALICQYEIGWCHLLQLEWDYALPSFFRLKEESKWSQGYYAYLCGVTIGLLGSNSEAQTQFKSVLKLVKKKTPLEEFLFRRASQYKKIEPSEDDCLLMALELLYVWRAFYSCSQDVLHRMARDLEGCRPSSNLIPLKILMQGSVFQILKNNDMAVKYFQEAIHKSGRSPPDSHVPPFATYELGVLYAQDTRTSDKGEELLRRVKDNYNGYDFENRLSFRIHAAMARIEERKLESASSNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJV5</accession>
    <name>A0A6P8HJV5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292064</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555163.1">
        <property type="nucleotide sequence ID" value="XM_031699303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJV5"/>
    <dbReference type="GeneID" id="116292064"/>
    <dbReference type="KEGG" id="aten:116292064"/>
    <dbReference type="InParanoid" id="A0A6P8HJV5"/>
    <dbReference type="OrthoDB" id="10270292at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555163.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16267" checksum="971428380A3C8C69" modified="2020-12-02" version="1">MDIISVQEYPRKRCAPSSPLEDSILLQQPKRSCSSEYYLHEMSNCYRTHEIFADGSMPTLAKKTVSQPNEERMDCSDSNIQSENNDNTYMSKKHVELSKDDRPQEQEKPIPNLYVASSFRRSPVKCSRCCAGESAHFSHLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLS2</accession>
    <name>A0A6P8HLS2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116292695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555908.1">
        <property type="nucleotide sequence ID" value="XM_031700048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292695"/>
    <dbReference type="KEGG" id="aten:116292695"/>
    <dbReference type="InParanoid" id="A0A6P8HLS2"/>
    <dbReference type="OrthoDB" id="6234674at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031555908.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45260" checksum="E3977AE9AFC5BBA7" modified="2020-12-02" version="1">MRYGIYRFHYSVIVYGSDIDTAFDFGSILPNKQSILDAIMNIKRYDLATQANDKLAFDQARDIFTTKPTRKEARKVLVVITDKQSSNSPSELEKARMGLDQINASIVAVGIGSQVTLHGLFDYTVIKENVIHVPSGGVSYLLAEEIIHKISRGAPKFTKIPSSVLHVVEGGNAKLVWEYEHPKKKEDQNSLSLQWDFYSKNGSRTEIATAHANSNWEFKLSSTCPKRLQNPTRVSKANPATFFIFIVTRADXGQYGCTIRMKNLTTTTLVRLVVTAHPQFTIRPPLVMYINEGQDLYIQCEAQGPPVPMVTWYQNLGAARVLKSQGLGKASLSIPKIKRDQNGTFECQVNNNPNEMPVTAKTTCYCQLGSTINCKRMQQIYGNWSRCNCCAVSIGSRSPSCLYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM50</accession>
    <name>A0A6P8HM50_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RILP-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553720.1">
        <property type="nucleotide sequence ID" value="XM_031697860.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HM50">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="GeneID" id="116290751"/>
    <dbReference type="KEGG" id="aten:116290751"/>
    <dbReference type="InParanoid" id="A0A6P8HM50"/>
    <dbReference type="OrthoDB" id="10069524at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF4">
        <property type="entry name" value="RILP-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="7">
        <location>
            <begin position="304"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="155"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031553720.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="44024" checksum="3ECDDCF2F64D05AC" modified="2020-12-02" version="1">MALDLTTADVYQQASVIGQDIEKIIDRYGHEAVLDLMPRVVQVLEELELLVCEREKEKLEIAELKMENERLYFEIKREACQRRKLEEELFHAXKDGELKRLKSMVDKLQEENKRLRMEYEVSANERPVTTYVSAPGDAEVMQKMKETIDTQRDVIRSRNLEIESQKADVEAMEEQIERLANINESLRKNLAVQQSRMNGLAKEKAEHEAELKILKLELSEQEAEYQGVDGERKCSDGDVDSFIEDDFAKMDVQLHQKAEKHAEDLHNGKEVSKRENVADKEKTLDQNNENAESSTKTLERDPNRPRYTRAEFQEILAERNKFKEEVFFLKEDLSCYISEDEKKAEINPEKSPNTQRKCEESGISKIFSIFSSRKTNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNF0</accession>
    <name>A0A6P8HNF0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116293860</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116293860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557211.1">
        <property type="nucleotide sequence ID" value="XM_031701351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293860"/>
    <dbReference type="KEGG" id="aten:116293860"/>
    <dbReference type="InParanoid" id="A0A6P8HNF0"/>
    <dbReference type="OrthoDB" id="5976867at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557211.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="42095" checksum="1BB2B80EB8A5440D" modified="2020-12-02" version="1">MVSLPTLARSTEGVLLANSALPQKNRDEKFHHELFCETQIDKFTLIPLKNGDGSTDSNQGPVSSLLDKVDSPGIRDDDVVQNGERLSNEFDDLTFKAPASTVTWDSLFKLNLGSQDGRNTKVIEPLDRYFASVEKDILSRQQFDMEFFSTHGSGKKTAAKNRSLYLENELNSEVNDEINVKSTRTKGKHTLELTVDPALRVSARDSCHGNSHHIQYGDMFRALLHRTEPQNKEKSKLIHDNAIAEQKLKEANVIIERLTEKIQRRRLILKCKEDRQLSLEENIESLKXERDEKQAECMNLITQLNVIINERGNKIDELAIRKIKAEASYXQELQNNIELKSKLESKERHIKALKEKVEKARKWKNDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNV1</accession>
    <name>A0A6P8HNV1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558044.1">
        <property type="nucleotide sequence ID" value="XM_031702184.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116294557"/>
    <dbReference type="InParanoid" id="A0A6P8HNV1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050179">
        <property type="entry name" value="Trans_hexapeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43300">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558044.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="66882" checksum="6DEECDF1DC8C2313" modified="2020-12-02" version="1">MLTTYTTFLMFLFLTFLDVYELIYTTIGIQGITWLLLCLLLLSIPLYIAYTMLVAFIIKKIFLGSVEPGIYALWSMYYLRWWIVKSAMSMVPTYLVSGTPLMPLFARLMGARIGSGVYYNTYSICDFDLLEVGSGVSIEDHVSLDTHRIDRGTLFLGRIIIEDNCSIGARSSIAFNSTIKRNTHVEPLTLVTDNSKIEENSHVHGSPATIITKKTSEQFRMFWLSLVILAVPYLKDAFANLRVDVIAMVIPIIAVFGQTTNLLLTAVLKWLFVRRLKEGVFSINSSTFLCYWIQQRIIIIVLKSSKELFATLYTNLWLKTLGVKVGPHVEVSTAFNFVPDLLELKEGSFVADHVSLGGAVFKDGHFSLTXTVIGQRTFLGNNSVIQAQSFVGDNALIGVLSXTPDIVXXKTFWLGSPAFRLPARAQAXKVHSSSRTFNPPWYLYVSRLXWEFFKIFSPPLVRLYALFGIWMLVAKVSYPVFQEGTPLFWLSASFWTLGIVVCVLSLVILLKWILIGRFRPGERPLWSSFVWRSELIASLEENIAMPFGVSGLLGTPMAAYWYRAMGAKIGSRVYMASKYLTEADLIEIGDDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPA8</accession>
    <name>A0A6P8HPA8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558224.1">
        <property type="nucleotide sequence ID" value="XM_031702364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPA8"/>
    <dbReference type="GeneID" id="116294719"/>
    <dbReference type="KEGG" id="aten:116294719"/>
    <dbReference type="InParanoid" id="A0A6P8HPA8"/>
    <dbReference type="OrthoDB" id="5986186at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031558224.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11783" checksum="0D518011D62BAB32" modified="2020-12-02" version="1">MSGAAVVAVREEKARFGNIEVTKETALVATEEGIVAIERHRIEEHQPMRALPPPQQQQASWYDPRGKGCCVGFLLMLMWIVIAVILLPFFILVCICYCCFGKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPB2</accession>
    <name>A0A6P8HPB2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116294721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031558229.1">
        <property type="nucleotide sequence ID" value="XM_031702369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPB2"/>
    <dbReference type="GeneID" id="116294721"/>
    <dbReference type="KEGG" id="aten:116294721"/>
    <dbReference type="InParanoid" id="A0A6P8HPB2"/>
    <dbReference type="OrthoDB" id="25592at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031558229.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13807" checksum="2CC9F84420E23945" modified="2020-12-02" version="1">MANELPYGKEIDIWGLGIVAMELFQGYPPLRVADCMQCFVSMAKSGYTIMNNEAASRASEDLINFLYNGTLKYNPADRLSADELLTHPFISTHEHWSRCCDCLSSFMKYVLEVQKLRLDDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPQ7</accession>
    <name>A0A6P8HPQ7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase Nek7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558359.1">
        <property type="nucleotide sequence ID" value="XM_031702499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPQ7"/>
    <dbReference type="GeneID" id="116294827"/>
    <dbReference type="KEGG" id="aten:116294827"/>
    <dbReference type="InParanoid" id="A0A6P8HPQ7"/>
    <dbReference type="OrthoDB" id="10252634at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF613">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOCS box" evidence="2">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558359.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38760" checksum="E2B50D16062DCA02" modified="2020-12-02" version="1">MATRSLLDLRFDLQCNTVPSKQQPYSLQHLCRKNIIVCIIKSVGLFEVHKACAKLPIPKIVVNYLTNSSTKDEHFDIRTWGSLVELGYSGKCLLYGELVTLKCIDLRRTVRILRNEAIQFKDKWMSVDHENISKAIVCFEANNVIGAIFEPCAPSIKDIVAQYSDMNEQIDEKYIWSVLGQLSSALMYLSKNGISHYKLCSKMISVTGTWEVRVQNLLMHYSINDSLTPLQEDMYYGMYLAPERIEGRPCKDKQDTWLIGCIAYEMIHRKTAFKVHEGMSLFETLNNIVKGCPPPQLSDLNGYSSELMNLTRACLTHLEQVRPSLEEVHLAIQNNISGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPX7</accession>
    <name>A0A6P8HPX7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Diacylglycerol kinase</fullName>
            <shortName evidence="14">DAG kinase</shortName>
            <ecNumber evidence="14">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116291646</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031554692.1">
        <property type="nucleotide sequence ID" value="XM_031698832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPX7"/>
    <dbReference type="FunCoup" id="A0A6P8HPX7">
        <property type="interactions" value="1821"/>
    </dbReference>
    <dbReference type="GeneID" id="116291646"/>
    <dbReference type="KEGG" id="aten:116291646"/>
    <dbReference type="InParanoid" id="A0A6P8HPX7"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20800">
        <property type="entry name" value="C1_DGK_typeII_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20852">
        <property type="entry name" value="C1_DGK_typeII_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000001">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054474">
        <property type="entry name" value="DGKD_4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF109">
        <property type="entry name" value="DIACYLGLYCEROL KINASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22944">
        <property type="entry name" value="DGKD_4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="227"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="19">
        <location>
            <begin position="308"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="18">
        <location>
            <begin position="1158"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1230"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031554692.1"/>
        </source>
    </evidence>
    <sequence length="1252" mass="139612" checksum="0E2330C77AC815B1" modified="2020-12-02" version="1">MTSILEDKEAKSDGRLHNLSSPKRVFCNGVYPQSQMKKLKTMHCVKEGHLLKQSGSFQRWKKRYFKLREGKKLFYAKNNNQNTIFNEIDLQDVSVAETGIRNANNSFTVITPYRSLVLCAESRKEMDEWFGCLKALCNRRSTQSDILDQLTGTHNWYSCAHSRPTFCNVCKDILSGVTSKGLSCEVCRFKVHRRCAAKAPNNCKWTTIQSLKREELEFDESDPMSVPHQWQEGNLIPGSRCSVCDRQCGSKRRLQDFRCLWCNMTVHSACKPSAATKCTLGENALSILSPLCLEGPMGPGRLEAFKPTGLSPLLVFVNSKSGDNQGVKFIRKFKQLLNPIQVFDLGVGGPQQGIQIFKQFSRFRILVCGGDGSIGWVMKEVDNMNLTNKVQIGVLPLGTGNDLSRVLGWGTTFTDDSAVPQFLQHLERAKALMLDRWSIMTQECNPTLPPSRSSSIEGLDSPIPYQQEFDNMYMFENNVAAHLTRILHSSQHHTVISSAKVLCETVKDFVSKVGAASASSDPEEAKEPGSLAQKCEILNEKLNLLLKALSIESEASPPPAKEEISDLSENNSVNNNGKTQKVFVPREALMSRANSLKKALKQIIQHTETAVDEQNARTSPSTSSLAKAIVEGATAAADEVVTTSSSAPVLESVLESTADQELESELPSYLDVNPIDKLLSEPDNDVAVDMQASNNLSAAPVSRSDARFLSRGSSYPYQYEPSFDDLLAKQSSSKSTVQFNSCIISKAFLKDRPKDSIVGSLIGKALLANADALCAAATPMMNTISDVDGYNEKCTMNNYFGIGIDAKICLDFHNRREEHPEKYRSRKKNMIWYGFLGGKEFVQRTYKNLDQRVKLECDGNRISLPSLQGIVVLNITSYMGGANFWGGSRDDGFTQPSFDDSFLEVIAVLGAQQMGISKVFGGMQHHRIAQCRVVKITITGEPIPVQVDGEAWMQTPGYIKIVQKNRAQMLVRDRAFENTLKLWTDIQQEKNALINDFENETLKSLAVAITPLIQSVREASKYSPELEEDLFEWSTMIERLLPDNKSQENLSRTRAVDFLSNAKAFTQEVIWFLNEKLQSLVPPLREDKLTSITTALNAVEPELLRAVDVCGLPDLDDERDKATNSKGKSKFSFGLLRSKKPEMTKAVTAPAGRMIQYWGVEEVGRWLENIGLVEYRDLFARNDICGNELLNLTRPDLKDLGVTKVGHIKRILHGIKQLCGGLSPRSAAKIERTSKCEEKPSRSTYLDKEYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRM0</accession>
    <name>A0A6P8HRM0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116294323</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116294323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031557768.1">
        <property type="nucleotide sequence ID" value="XM_031701908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRM0"/>
    <dbReference type="GeneID" id="116294323"/>
    <dbReference type="KEGG" id="aten:116294323"/>
    <dbReference type="InParanoid" id="A0A6P8HRM0"/>
    <dbReference type="OrthoDB" id="5989737at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031557768.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="26113" checksum="8CA96C0EA2105768" modified="2020-12-02" version="1">MLLSVFFEKDAENIRALSRYLDRRSLVIKNYEDLANRLNAPTLIKAKCKSNTTEHSPTLDLMQSPKVSTLKVNVLVRNLRAISRNDVANLIEKGIPENQREWLNVKDAINDYGELFDEVASKLDPKSINDWKILGRKLGFQFDELKQIGLGCNPTERLLVDYVYTTMNPEELTVARFRHLMEEIEKPNLLRKSGINERLYHRCRIRYYQTSRSISFFMIESWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRS5</accession>
    <name>A0A6P8HRS5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Diacylglycerol kinase</fullName>
            <shortName evidence="24">DAG kinase</shortName>
            <ecNumber evidence="24">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC116292254</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="28">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40323"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="22">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 24">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="24"/>
    <dbReference type="RefSeq" id="XP_031555392.1">
        <property type="nucleotide sequence ID" value="XM_031699532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRS5"/>
    <dbReference type="FunCoup" id="A0A6P8HRS5">
        <property type="interactions" value="1556"/>
    </dbReference>
    <dbReference type="GeneID" id="116292254"/>
    <dbReference type="KEGG" id="aten:116292254"/>
    <dbReference type="InParanoid" id="A0A6P8HRS5"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20802">
        <property type="entry name" value="C1_DGK_typeIV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000204">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056383">
        <property type="entry name" value="DGKI-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF80">
        <property type="entry name" value="EYE-SPECIFIC DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23578">
        <property type="entry name" value="DGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 24" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="26">
        <location>
            <begin position="272"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="23">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="23">
        <location>
            <begin position="877"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="737"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_031555392.1"/>
        </source>
    </evidence>
    <sequence length="948" mass="106429" checksum="1C6AE344EE79E9D6" modified="2020-12-02" version="1">MAGKSKGHKENLLEVKDVEDETRPSLQNASKVSRGAAKSRSYKQAMATPDINCKPSSQTDRCDNHEMMAASCSTSDVSDWTDNAVNGRHFWIDSDASANFCYLSDYECVKSGPRKKCTACKIVVHTKCIEQLERINFRCKPTFREIQTKGVQEGSIRHHWVHRRKQEGKCEHCGKSFQHMLSFQNKDIISISCSWCKVAYHNKVECFEMKKIDEPCDLGAHANLIVPPSWIVKIPRKGRSGSVKRNSFKKRSIKRKSTKERKPFVIKPSGSAQKKPLLIFINPKSGGNQGAKIMHKFQWLLNPRQVFDLSSSGPKEGLELYRKVPNLRILACGGDGTVGWVLSELDKLKVSPPPPVAILPLGTGNDLSRVLNWGGGYADEPLSKILTHVEEGTVVQLDRWNLDVTANESGDISDDDVPKVHKLPLNVMNNYFSLGFDAEVCLEFHEWRESNPGKSNSRFKNFMFYGKASSTTFLQGKAKDFYKYSKLECDGVNLTDKLLEIKPLCLLFLNISKYGAGTSPWGNPGRDNDFFPQSNEDGLIEIIGFSSSSLAATRVGGHGERIAQCKEAILVTSKTIPMQVDGEPCRLAPSRIRISRRNQVDMLQKTKRRGLGSSSSADPMPCIETVKVQIYCVEFQDYEKHCYDISKLRESASILATTTIEPDSDLEQMRAWIERFSMEEEEEDKSCLSDDWCFLDTTYPDRVYRVDVAQENIYNVVDILDGGVFIVDLNRKTQKKPSDTVSVSSLPATIKDTDAPSSPFPDSKMNPQAKNGPTSYSVPCTPTGKETFSLSVKEDQNHVWVKISDAKRNEQLMIDASKNGDLEKVIDLHQKGVSLSAGDHRGWRPLHYAARHGHKEVIRYIISNVPRCVLDLVEEEKGQTALHKAAFYQRRTICSLLVQAGASLTRTDYDGNTPRIQALKSQDKELAKYLETQEHLQIIAAEDYETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HS83</accession>
    <name>A0A6P8HS83_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 184-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555557.1">
        <property type="nucleotide sequence ID" value="XM_031699697.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292387"/>
    <dbReference type="KEGG" id="aten:116292387"/>
    <dbReference type="InParanoid" id="A0A6P8HS83"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="842"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="933"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031555557.1"/>
        </source>
    </evidence>
    <sequence length="1014" mass="116194" checksum="21D468E2A274D160" modified="2020-12-02" version="1">MECGWYAYQSKSGETLFFFNKITGQYRWLSCSCSKNLEPWIPDVNSFGGIASEVIEYDKPDNMTSVHVRSIATETDLPAARKTLNTQGTQTECLDDISCTDDPLSQNVLSTIILNNSNHKKVLLGDNSKPVLSRNTFLLQENNSSCKCRGEENCNGSSTESKQTYKKVKLFECSYCEKAFTSYAFLVKHEKYHVENDSQKKVCDDLEETRSVNSISFDPEVEQEETKKNCHLMKGVTKQNTVVSTLINTPPSTQADSIPFFQACFQCGKSCTMSDEFDSHLQEHLKEQFCNPCRKSFKDANQFMKHICSYHVTLRRKCHLCKGKYLLKSSLTNHLWHFHKVASNDEEERGAVSYSQKCGSCEASFKLSDKLMEHQRAMKHKGIKYQCHGCGKLYAVLIDLQQHLIQEHNLDSQSTSSSLSSNSHKKPSQHKESLIKKIKSLDSVQPDRDAQRYWCNECGVSYTWSCDLVKHKIKKRCCLDRPIVQMIGNSQHYICSYCDRPFDDKEQFGKHYVNHFKKNTPINCDRCTKTFSTFQSLENHFAVHLEEKIKEANNKGYLKPYSCEECGKSFGTVRNLRRHIKRNHTKEKQDKAMGKFCCDICNKVYSHGSTLSTHKKTHSVQNNSFPQRAAQTSTSTATEPVTKLKRPAEINANKNGNLRKFKCNKCHRTFFNAECLSRHKKLLNHGIVLHLRSSHVANTVEEPKSRSQNIYNCQVCQKSFKYYNMFYKHRSAHKVEKVRGCTICGKFFKVNALSSQRLCLSCKKAPPKITKDFFSCNICGKAFLESRSLKGHMQAHSKGHFDCMSCSIAFSSAERLNEHMRNHKNEVRKLKNFKSKFKGKFHECNNCQKXYSSRKNLVRHRKICMRKENNQPGSSPVNIAVKKNSAVKKNSVGKKAQKKNDKNNQNYSCQKCQKSFVLFSEFYSHCSEHGEEKPCCKCDKLLSSSSSLKRHLTEIHSGDHTFYCHICSEEFYSLNGLVNHITLVPGAKRHKCNECGQVFALCNGLMDHVKTHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT94</accession>
    <name>A0A6P8HT94_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Melanopsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116292645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031555857.1">
        <property type="nucleotide sequence ID" value="XM_031699997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292645"/>
    <dbReference type="KEGG" id="aten:116292645"/>
    <dbReference type="InParanoid" id="A0A6P8HT94"/>
    <dbReference type="OrthoDB" id="5980559at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031555857.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31763" checksum="365BA2C92EBAC307" modified="2020-12-02" version="1">MNXLYFTTHSXAVSYNLAGKEMNREDNLRCGWLAFINCFTGIVAIITLSVMSFISYLGITQVSTAESSRIPKKTMMIIIGSIWLFSFAISVPPAFGWSSFVPFENGISCHPDWVSQDTXDQAYIALLVTGGFFLPLITLVYCYSKTYRYIKGNTFPVSGSNEAVLTRQMETQKRMIRMTVVAVILFFISWSPYCIVSLMATAYGRPILKGGISLVPELMAKASVVYNPLVYTFMNTKFRVTLKNVLRLNYNAVNPTSSDEICDASVTDVGPQTESGVVKVDKFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HVP9</accession>
    <name>A0A6P8HVP9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116295687 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116295687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559451.1">
        <property type="nucleotide sequence ID" value="XM_031703591.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295687"/>
    <dbReference type="KEGG" id="aten:116295687"/>
    <dbReference type="InParanoid" id="A0A6P8HVP9"/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY56</accession>
    <name>A0A6P8HY56_ACTTE</name>
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            <dbReference type="RuleBase" id="RU363034"/>
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            <dbReference type="PROSITE" id="PS50060"/>
        </source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031560281.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="44802" checksum="318DE6FC26ED7EE7" modified="2020-12-02" version="1">HRNGGFICGGTLIKRDWVVTAAHCVTNNNPSAYFVRLGDHNRRVQEXTEQDIKVIRIISHPNYNNPRLSNDIALLQLEKQATLNSRVGLACLPAHNYDLPAGSNCYITGWGKIRHPGSSHHILQQAHMPSISHAECKRKNGNIGITITDVMLCGGKANTQISGCHGDSGGPYVCKNSAGRWVLQGDVSWGNSRCDSSQMYTVFGRVAKFRNWIDMHTLGGTQPPTQPPTPPSVQDMNNDFNTLGAWRQATNDKFDWTLHSGCTASSATGPCADHSGSGKYAYIETSSPRVSGDNARLTFNGNYDGDLCMTFYYHMYGSSIGSLKIYDNGVVVLSKAGDHGNQWMKEQVGLSSNRNVAIEGVRGSSYQGDIAIDDISVTKGRCASTGTQPPTQPPTQPPTPQPPTQPPSQGMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYS0</accession>
    <name>A0A6P8HYS0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Protein-cysteine N-palmitoyltransferase HHAT-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13 14" type="primary">LOC116294356</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557800.1">
        <property type="nucleotide sequence ID" value="XM_031701940.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557801.1">
        <property type="nucleotide sequence ID" value="XM_031701941.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557802.1">
        <property type="nucleotide sequence ID" value="XM_031701942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557803.1">
        <property type="nucleotide sequence ID" value="XM_031701943.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557804.1">
        <property type="nucleotide sequence ID" value="XM_031701944.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031557805.1">
        <property type="nucleotide sequence ID" value="XM_031701945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYS0"/>
    <dbReference type="GeneID" id="116294356"/>
    <dbReference type="KEGG" id="aten:116294356"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031557801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031557802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031557803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031557805.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="62604" checksum="25A198F7624AEFCE" modified="2020-12-02" version="1">MATTHNRFKNKDPTSDTPETKESSRMNEPKIKQFHYVSLSLVETILNWVIWLGTVAYMMYILVVVSNKHKDELYPEDFSKGWKIIGREKDSSDMEWEFWSSLKLEFVSSLAIHSIGGFIISYYIPKFKALFYLVYTLVFLVYLLGILPVVYMLVHLCIMYLASLSQSVLAVWGVALSILASLQMDDIRHWQYKYLTNDSQHRDLTLFISLMSLLRSISFCLDHCSHKKNTEEKEPASSYSFFNLLSYNFYLPLFNNGPVMMFDTFYKEFYQPPRPFTKEEILSLIWDSLRTLWWYICFEVYLHYVYSSAIVHEPPVFMDLSNWSLAALFYSQLHIFLTKYVVLYQLSRIFARLDRLDPPQIPRCVSSLYTFTDMWRYFDRGLNIWMKRYIYVPMGGSRKGVFRQLLGSFLAFGFVWAWHGGNPDTLWWFMPNWLGVAVEGFAENIAMSPLVMRVEEHLSLRMRRRIRAALCTVTLSGLILSNMVFLIGPRPVTIFVRRVFYQGFPSSSLVCLTCLYFSIQTSIDLNNYKGGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZQ2</accession>
    <name>A0A6P8HZQ2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CCHC-type and RNA-binding motif-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">U11/U12 small nuclear ribonucleoprotein 31 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116294594</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558087.1">
        <property type="nucleotide sequence ID" value="XM_031702227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZQ2"/>
    <dbReference type="FunCoup" id="A0A6P8HZQ2">
        <property type="interactions" value="2112"/>
    </dbReference>
    <dbReference type="GeneID" id="116294594"/>
    <dbReference type="KEGG" id="aten:116294594"/>
    <dbReference type="InParanoid" id="A0A6P8HZQ2"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12393">
        <property type="entry name" value="RRM_ZCRB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000233">
        <property type="entry name" value="Zinc finger CCHC-type and RNA-binding motif-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000009">
        <property type="entry name" value="Zinc finger CCHC-type and RNA-binding motif-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044598">
        <property type="entry name" value="ZCRB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034219">
        <property type="entry name" value="ZCRB1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259:SF1">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="17">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="16">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031558087.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23707" checksum="02A6580FDBEE2F91" modified="2020-12-02" version="1">MSGGLAPSKSTIYVGNLPYSLTNSDLYKVFSRYGKVVRVTILKDKESRESKGVAFILFLDKQTAQAAVSSVNNKQMFGRTIKCCIAKDNGRASEFIRRREYPDKSRCYECGECGHLSYECPKNVLGERERPPKKNKKKKRKLEEEEVEEEEEEQQGEDPSEWSLGAAIQECARLADEKEEPHKVQQPSASKKRIVQSSYFSDDEEYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I034</accession>
    <name>A0A6P8I034_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RPA-interacting protein A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116294765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558285.1">
        <property type="nucleotide sequence ID" value="XM_031702425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I034"/>
    <dbReference type="FunCoup" id="A0A6P8I034">
        <property type="interactions" value="2071"/>
    </dbReference>
    <dbReference type="GeneID" id="116294765"/>
    <dbReference type="KEGG" id="aten:116294765"/>
    <dbReference type="InParanoid" id="A0A6P8I034"/>
    <dbReference type="OrthoDB" id="435311at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028156">
        <property type="entry name" value="RIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028159">
        <property type="entry name" value="RPA_interact_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028155">
        <property type="entry name" value="RPA_interact_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028158">
        <property type="entry name" value="RPA_interact_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31742:SF1">
        <property type="entry name" value="RPA-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31742">
        <property type="entry name" value="RPA-INTERACTING PROTEIN RPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14768">
        <property type="entry name" value="RPA_interact_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14767">
        <property type="entry name" value="RPA_interact_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14766">
        <property type="entry name" value="RPA_interact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RPA-interacting protein N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RPA-interacting protein central" evidence="9">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RPA-interacting protein C-terminal" evidence="10">
        <location>
            <begin position="162"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031558285.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28557" checksum="CF57E37C21A6695A" modified="2020-12-02" version="1">MSSTMSSSSRDLDPFARHRSQYKFTTPPWKDTYKKRCMERLRNGRQRFVERFRQMDVSTSDPVNISSEVERVMNEEWSQIAGENSNLPSWKPTKESCQPFPGMKLDAEKESDLNEIISMMEEIQKELVEEEKMILREYNENLRFEEESLCAAIDKLSTDDVLCPVCKRNPLHQNKQVIFCQCGMRIDTEYDALDLSYVKSQIEESISTHRDEGCSTEPEFVVSDAIGLGASNLITQCKTCGFLYIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0P3</accession>
    <name>A0A6P8I0P3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116294902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558450.1">
        <property type="nucleotide sequence ID" value="XM_031702590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I0P3"/>
    <dbReference type="FunCoup" id="A0A6P8I0P3">
        <property type="interactions" value="1985"/>
    </dbReference>
    <dbReference type="GeneID" id="116294902"/>
    <dbReference type="KEGG" id="aten:116294902"/>
    <dbReference type="InParanoid" id="A0A6P8I0P3"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027081">
        <property type="entry name" value="CyclinH/Ccl1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00569">
        <property type="entry name" value="ccl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="159"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558450.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35309" checksum="B80CD21B62FE6C79" modified="2020-12-02" version="1">MFHTSTQRKHWTFSSPEEIENLRVSVNSEYKTRYNESITKKNVDDFLTTEEEKKLVEYYEVVLTDVSAKFQPPIPWSAVATAVTYMKRFYLKTSVMDYPPKEMYLICLYMACKVDEYNISAEKFVCILPGDRREKAIDFILSHELLLMQRLDFHLTVHNPYRPMEGFIIDMKTRMSINPDRWRAKADEFLHLALRSDAWFLFSPSQIGLAALSYGCEKAEVNRYVKEILGNNEKNAKLLQQVKQVISLVTKERLLVGKDQVKMLEKKLNTCRNPENIHPDAKFSKKIKSYKQNEETEMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1D8</accession>
    <name>A0A6P8I1D8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116295111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558702.1">
        <property type="nucleotide sequence ID" value="XM_031702842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I1D8"/>
    <dbReference type="FunCoup" id="A0A6P8I1D8">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="GeneID" id="116295111"/>
    <dbReference type="KEGG" id="aten:116295111"/>
    <dbReference type="InParanoid" id="A0A6P8I1D8"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558702.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="15115" checksum="82893466E4CE46EB" modified="2020-12-02" version="1">MADDRIGSSESSSDVEKEVPPWAKGETLRHVERDVLIPKIVREISREKCKPYLDEFTNCCKGRTLSMVWACRKENRVMQDCLQKYFKDNSIYEEAKHLYLQRRDEFQKDYAQHGEKTEFKKKESVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4M5</accession>
    <name>A0A6P8I4M5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxypeptidase N subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563514.1">
        <property type="nucleotide sequence ID" value="XM_031707654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4M5"/>
    <dbReference type="GeneID" id="116299031"/>
    <dbReference type="KEGG" id="aten:116299031"/>
    <dbReference type="InParanoid" id="A0A6P8I4M5"/>
    <dbReference type="OrthoDB" id="5967152at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031563514.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16308" checksum="E47085C4B8528456" modified="2020-12-02" version="1">FLYHNNLRSLPAGIFDRNKDLMKVHLGYNNLETLPTGIFDRNENLLQILLNNNHLTTLPVGMLKNSKLLNGIDLRNNQLITLPAGLFDENEKLNIIVLESNQLALLPDGIFHNLKALSALYLSNNRLSSLPAEVFDNNTELQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4N9</accession>
    <name>A0A6P8I4N9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116298193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031562431.1">
        <property type="nucleotide sequence ID" value="XM_031706571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4N9"/>
    <dbReference type="GeneID" id="116298193"/>
    <dbReference type="KEGG" id="aten:116298193"/>
    <dbReference type="InParanoid" id="A0A6P8I4N9"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007072">
        <property type="entry name" value="RNMT_CmcI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04989">
        <property type="entry name" value="RMNT_CmcI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031562431.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="30036" checksum="2EC1C56B91E9C994" modified="2020-12-02" version="1">MVIAIMHQGMNDATNYEALNVKVQDEVSKEHQLQKLEDRTDKSAYTLDAWKSICFGKYKTRWRGCILMKSPFIIVTYQQLFWDVKPRTVLEFGANSGGSAVWMADTLQMFGCKSHVYSVDIDLGLLEPLAREKRNDLTFLQGDCNEIQKTFPPEMLKSLPHPWFVSEDSHVNVVGVLDYIDQFTEPGDYMAIEDTNPLIPTASGASLFDDVKYEEWGREKLEHVEAFMKKHPTRYLIDKEYTDFFGYNGSEIMNGYLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4X2</accession>
    <name>A0A6P8I4X2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GRIP and coiled-coil domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116295993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559815.1">
        <property type="nucleotide sequence ID" value="XM_031703955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4X2"/>
    <dbReference type="FunCoup" id="A0A6P8I4X2">
        <property type="interactions" value="1386"/>
    </dbReference>
    <dbReference type="GeneID" id="116295993"/>
    <dbReference type="KEGG" id="aten:116295993"/>
    <dbReference type="InParanoid" id="A0A6P8I4X2"/>
    <dbReference type="OrthoDB" id="9898580at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.60:FF:000008">
        <property type="entry name" value="GRIP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="8">
        <location>
            <begin position="726"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="192"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="474"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="684"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559815.1"/>
        </source>
    </evidence>
    <sequence length="786" mass="90898" checksum="1E9DC2E813841EA2" modified="2020-12-02" version="1">MERKSRSELIRIIEEKSEKLSRYETKLRDVVSAYKNLVKEKEALDASIKVLTSTQQASPKPTRTNRKRTEGTSTDGLNQDQKNKEKTPASSPLTEENQETFNDGKFVSVNDHPLRENSHEDTKNENEKDKKKTTELEEEKNSDGNDVDDDDNDDETKLLREKITTLTSTLKTVMEQKSIMESNYQADKKKMMQDFGARQEELLKENEALSKKVIEVENQLKEAKHRMRQEQQSREEEENNNILMLRELQVLLSKERTAREELEQQLDEAKEKLSNTKSIPESKALEYEHQIQSLKEKLEEIQTRLMKAEETATKPSPLLLRLQEEMKEIKRENAEALLREQKRANEAEEKLEMITSVEESRVSDLETKLSELSEVVGNYEKLKFQDQMVIQKLKERLQQLDVENTALSQNSPTTEIPDNNRQTVNELESLREQMRKLKVASKYAVENSSLLKEGDLEELSKSELDSILNSDPTHKLCQEELKQLKDEFELYKAKTNPLHKGKSFKDLTSQLENLEKIKTRNTKLEKRIHEMQESAKQKETELKKIISDLKSELQNAENSLTSEKEECELIYNQKLAELEKQVLKQRERTLELLAEKDAEINSLRTRSPSASPSRVGTVSFSYPRRYLDPQLMVPSESLELGGGESSEDTNEAVCQLITRQTGLSSGEGVLIHYAQQQARREAESTALRRQKIELEDELREMALREARQGDQCKTLKEEIRKLERDRSRESANLEYVKNVVLRFMLSTSYSVKEQMIVAIATVLQFSPQELQKVRKAHAGGWWGSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I550</accession>
    <name>A0A6P8I550_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116299191</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116299191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563679.1">
        <property type="nucleotide sequence ID" value="XM_031707819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299191"/>
    <dbReference type="KEGG" id="aten:116299191"/>
    <dbReference type="InParanoid" id="A0A6P8I550"/>
    <dbReference type="OrthoDB" id="5969648at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="3">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031563679.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52944" checksum="95B12B86E6593DCB" modified="2020-12-02" version="1">MAGNSSDDKTRKLIDEFLCFTKRIGLEIVKEDIEIAIFLIEEKLPEENVLEIKKAKQPGVQLVSCLKNNRLLSENNLDFFIELLKECRRIDLANXVKEYRKTSVTTLKSAPPAQINEKIPGYKMESLFLVINGQKSSVTVNQLDHIRESISRALDLKISDVFYVATDEDEENPQYSQLRLQLPKTEEKINQLQIDAVNKKPWLTDLEVVELTVDNKSSIKIAEKKKGDVPKKPKNGEKQSKPPLLRNHSVLGLDPSLKIHCNQMLDIVLAIELPSTVDVNKRRAVVGKFESAMNKYYXWHKELHSFRLAAIKFGNHTNVPVRQPNQQQIAFLVKELSNDLKMTASVKPEVHCGGIMNSGLADALSMVHSLKDDMHREATKLCIVICFITSNSANLEHYRCCFGYDVIDLGHVLATDAVPLYIIGIDLEGTQTSPSQAPDNYLLSGLTAITGGRYFQIQDISLLEEVSQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I578</accession>
    <name>A0A6P8I578_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116299221</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031563709.1">
        <property type="nucleotide sequence ID" value="XM_031707849.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I578">
        <property type="interactions" value="966"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116299221"/>
    <dbReference type="InParanoid" id="A0A6P8I578"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16726">
        <property type="entry name" value="RING-HC_MIB2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16520">
        <property type="entry name" value="RING-HC_MIBs-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000044">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000078">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase mib2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18346">
        <property type="entry name" value="SH3_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
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    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="19">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="18">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
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    <feature type="domain" description="MIB/HERC2" evidence="19">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
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        <location>
            <begin position="475"/>
            <end position="507"/>
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            <begin position="508"/>
            <end position="540"/>
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            <begin position="541"/>
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        </location>
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    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
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        <location>
            <begin position="709"/>
            <end position="748"/>
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        <location>
            <begin position="804"/>
            <end position="838"/>
        </location>
    </feature>
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        <location>
            <begin position="935"/>
            <end position="968"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="21">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023043"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
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            <dbReference type="RefSeq" id="XP_031563709.1"/>
        </source>
    </evidence>
    <sequence length="979" mass="107372" checksum="D1B955F2876D3615" modified="2020-12-02" version="1">MEVGLRVVRGQDWKWGNQDGGEGFVGTVIVVGRSGSFSSPEKTVIVQWDGGTRTNYRCGHEDAYDLCILDNGPIGVVHKNVSCSECRQQGVEGMLWVCASCQGYTLCTTCYTNDKHSLDHAFYRKDSPSSTPVLVDKRQGQQKVSAQGTYLGSQVRRGPDWDWGNQDGGPSKRGVVTDVRRWENETFRSVVAVKWINGETNVYRRGHKGKVDVICVTPSFGGVYYKDHLPKLGFNYSSAAXPKKFTPLHDSGKCQFKVGEQVQIVLEAEVLKLLQXDYGGWNERMKEVIGIPGTIQKVLDNGGVKVQYKVGPSNTYTWAFNPIALSKMGDIQVNDTVCVLDDVTLVKKLQVGHGEWTDKMVPILGKEGKVLKVYYDGDIRVVVGSTSWTLNPAVLVKKRDAMAVREAEQQTQAVATAASSTTAEAEASLPSLLQSMTVSPIDTSSKLISAAGLGQYTRVRDILAANPREIDSNKSGKTALHVSCHQGHVDIVKLLLKSGARCDLQDNDGDTPLHYAAFGNKPLVASVLIQHGANMNIPNAINCTPVHVAVNKGHTDVVRVFVQANCDINLQDSSGNTALHDAITKDQSDIIHIIINSNHCDLKLVNQQGFNAFHKAALKGREQALSLILSKYPTILNIPKDDGFTALHLSSLNGHVGPVRTLLMQSGCEVNRVNENHQTALLLAVDKKHLEVIKELLEHGANTNIQDDVGDTPLHTAVANSEPRSDPVTMDMVRLLVQHGADATTRNNDNKNCLDLCRNTELAELLRTASTGQETVQEPDASDTASPPQKDSAPSDSMAASNACRLCNERVDCQFQPCGHSVVCYGCSHMFKACFQCKVEVENVVKLEQAAEKECVVCSDFPAEVVFEPCQHKVACTDCSFRMKKCIECQHKITRKIGPDGSVIETCQADKYGRNMDSLFYLEAKVREMEEAQICPICMENMRNVAFLCGHSTCDECCKSLTDCPMCRKPIDKKITLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7F0</accession>
    <name>A0A6P8I7F0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116299402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_031563918.1">
        <property type="nucleotide sequence ID" value="XM_031708058.1"/>
    </dbReference>
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        <property type="interactions" value="3170"/>
    </dbReference>
    <dbReference type="GeneID" id="116299402"/>
    <dbReference type="KEGG" id="aten:116299402"/>
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    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="248"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031563918.1"/>
        </source>
    </evidence>
    <sequence length="1407" mass="157549" checksum="BDB955CC3D2CBB77" modified="2020-12-02" version="1">MVKEQFREAGVTKKISHVNFGMFSSEQMQQYSQLECVSKNLYNQDNSRKPVPFGVLDAKMGTCSKDRTCDTCGKGLADCVGHYGYIDLELPVFHVGHFRATVVILQCICKSCSRVLLPPAEKKKLLDSLNRPFVSALTKKAIKKKIIEKCKKIAHCPYCEALNGFVRKAGLMKIVHEKYKSTKKIVDPEITTFQSSFESALEYNKDLVNLVHKAQEVMNPLKVVDLFKQIXEKDFPLLMLRPGFSHPQDLILTRVLVPPVCIRPSVVSDLASGSNEDDITMKLTEIVFLNDVIRKHRAIGAKVQMIMEDWDFLQLQCSLYINSEMSGIPLNMQPKKGTRGFVQRLKGKQGRFRGNLSGKRVDYSGRTVISPDPNLRIDQVAVPVLVAKVLTYPERVTKSNMELMKKLVLNGTDKHPGANFIQQRETNIKKFLKYGNRKLIAKQLKCGDIIERHLMDGDVVLFNRQPSLHKLSIMSHFATVRPSRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEAMVLMGVKNNLVTPRNGEPLIAAIQDFITGAYLLTYKDVFLDRSHFTQLCSAMVAGRDIDKVLDLPPPAIIKPCCLWTGKQVINVLLRPNKKINVKMNLRAKGKQYTSNEDLCNNDSFVVIHNSDLLCGALDKAVLGSGSKNSAFYVLLRDYGPQYAADAMWRLARICPFFLSNRGFSIGIGDVTPGQGLLKAKEDLLDTGYSKCDEFIQDFKEGKLQTQPGCSAEETLEAVILKELSVIRDHAGKACLRELHKSNTPLIMALCGSKGSFINISQMIACVGQQAISGKRIPDGFEDRSLPHFKRHSKIPAAKGFVKNSFFSGLTPTEFFFHTMGGREGLVDTAVKTAETGYMQRRLVKSLEDLCTQYDHTVRNSVGDIVQFKYGGDGLDPTDMEGKDKPLDFQRVLNHIQCNHVMRTENPLPPQSVLQRVNKIIDGEQFVDCSDDFKNEVKAFMDGIAKKIDQTQLKYGIDFDMNEDDEEDGFSPHPKVLNYVTRLTESQLRMFLIMCRDKYLRARMEPGTAVGAICAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASRKISTPIISAQLMQDNDAELARAVKGRIERTLLGEVTEYIEEVYTPDSCYLLIKLAVPRIRLLKLEVDAYSIRTSLCEARKLKINPQNVQIHSKAVITVHPTENSKSSLHYMMQFLRGELPNVLIKGHKNVNRAIIHIDDESASGEERYKLLVEGDDLQGVIATMGVKGTGCTSNNTIEVERVLGIEAARQTIMNEIIYTMKNHGMSIDVRHVMLLAELMAFKGEILGITRFGLAKMKESVLMLASFEKTADHLFEAALHGRTDPIDGVSECIIMGMPMNVGTGIFKLLHKPTKPGIPSRRPLIFDNKEFHLPPMMAAAGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8G2</accession>
    <name>A0A6P8I8G2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM133-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560950.1">
        <property type="nucleotide sequence ID" value="XM_031705090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8G2"/>
    <dbReference type="GeneID" id="116296965"/>
    <dbReference type="KEGG" id="aten:116296965"/>
    <dbReference type="InParanoid" id="A0A6P8I8G2"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35760">
        <property type="entry name" value="SI:CH211-22I13.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35760:SF1">
        <property type="entry name" value="SI:CH211-22I13.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560950.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21944" checksum="416EA1A1D977BFF1" modified="2020-12-02" version="1">MVDEEYSKVRKKGDDKEELEGETSRPYRRKLKNKEKDKKRQRSRSRSSSSLSSDCSRERSRSKDKKKKKKQRYSSSSSSDGSSSSSDNSEKKRKLKRYSSSSSSDGSSSSSDSSAERRKKRKKSKKKKSKKDKKSSKKSGPVQLSQFMKEKNSSRSAVSGKKIKMKVKKSSKDKEMEKNRKHLLAFLNQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8T1</accession>
    <name>A0A6P8I8T1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300277</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031564974.1">
        <property type="nucleotide sequence ID" value="XM_031709114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8T1"/>
    <dbReference type="GeneID" id="116300277"/>
    <dbReference type="KEGG" id="aten:116300277"/>
    <dbReference type="InParanoid" id="A0A6P8I8T1"/>
    <dbReference type="OrthoDB" id="1922121at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19239">
        <property type="entry name" value="GIY_YIG_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028386451" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564974.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21537" checksum="104D1291BAA5870E" modified="2020-12-02" version="1">MKAFTFGVILLVLSLNVKGSFERIKREDVRRVAQLTNSRWSSWYTALVPRAPRRNAKNYERRDEGHYGFIYSKIRERFLSYDDGIYELRVVRGNRKPVVYIGMAHRDGPGSMNQRILEYCRDGSHKGDLINRAMRLGYTLQVRVQNIPGSAYHVRECEKKYLDAYDYAWNEINNGRIRGNVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IAN2</accession>
    <name>A0A6P8IAN2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116297645</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561765.1">
        <property type="nucleotide sequence ID" value="XM_031705905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IAN2"/>
    <dbReference type="GeneID" id="116297645"/>
    <dbReference type="KEGG" id="aten:116297645"/>
    <dbReference type="InParanoid" id="A0A6P8IAN2"/>
    <dbReference type="OrthoDB" id="10274538at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561765.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42268" checksum="217FFB5085658923" modified="2020-12-02" version="1">MTSHSIQDCISCLKSQTSANQVPKVFNVLQDFEESGLDPLLGTFSNILGRDTIPHVLSFLRTFRVLDVSDCELITNRNVHKTTQEEIMALVDRLNTKGPHAYWFFVHAMESLNQDFFDQMHGKIICCVCEDVAQNYNLVSQKEIVKECLSTEPSVQISKQREMINDLLGRVEQLKVSFSYLENSITDIMDKMKPFPGMVGNISQRVRNEIKDVIQHPGADEEVGSHTNVGVIKRLKVKCSQFRRQIECRLHSHSRQVQVDMDDIKSDALQDIVCKEPKPIDDDNKRESKELLPCRTYEDVWIEFEDRCFETLSQCNPFVAIQNSLGNVLLFGQKHKAKVCCAVGLAICMKIAASYLLEYSEWTGGPRPMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE10</accession>
    <name>A0A6P8IE10_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116300114 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564787.1">
        <property type="nucleotide sequence ID" value="XM_031708927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300114"/>
    <dbReference type="KEGG" id="aten:116300114"/>
    <dbReference type="InParanoid" id="A0A6P8IE10"/>
    <dbReference type="OrthoDB" id="5952306at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027605153" evidence="2">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564787.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44943" checksum="13983B74C48CF638" modified="2020-12-02" version="1">MSSTTVLLILVAGLSGVYADLLDNLNCNRTHFTHGVSLCQRIALERLARSKDITCDSVYKKQVTCIDNHVQKCLEGTSYAMYEKIIVDLLNIITFNCGNVSPNLNFFVFQMLGCKDGTLENXKKAVKCWNDFVSKHKANRKYSTLCRSLADAKKCVANITNHYCPAVKLEADPCNPFCANGTDDHHECPGKVWTHQQLPVLSISLTCKKDFYYMKEKECERIFIDSLTNQTNTSASCSTEVPKLKSCIKKHYSENCFDPLVDDVLLENLIEGVSSVTKGQRMFCNAVTITDRSAALRDIVPCGSSFYAEVEDCAKEFREKFLANSKNLSLCSVYEKAKSCYSTLQAKHCQFSPSILQILTNDTYNPFCVALQPKVSCGLAMYFNWSSLVSSLLAVIVILLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IED3</accession>
    <name>A0A6P8IED3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565152.1">
        <property type="nucleotide sequence ID" value="XM_031709292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IED3"/>
    <dbReference type="GeneID" id="116300420"/>
    <dbReference type="KEGG" id="aten:116300420"/>
    <dbReference type="InParanoid" id="A0A6P8IED3"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="288"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565152.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="53789" checksum="B403440D9E8958D9" modified="2020-12-02" version="1">MHHGKVEAERMLKQGLPLTPTRNQLAPCRTIKISPKTSQMDPNQESISAEEITVSRWKRFTRTDGPWSWLLCLLLLTSCLVVYGCSSTYGIMFPGVLEELQSGKAITAIPGSLSLANSGLLGPITGQFYDRFGCTRAMLLGGSISFIGLFTSSFAPNSGILILTFGMIFGSGLSLVFLSSLLVIPEYFKKYAFQATSLVSVGPGAALLVMSPVVQRLFQTFGWRKSMKVMSGLAFCPCIVGLMMCAFKGKEVPTRHSYTERNRQNSDLEPSKTRCNGLINVSVFKNKVYVLTSVMVTITSLGHMMPFVHLAKYCEDIGIPSDHSSWIYFSIGLSSLLSRVLVGKYGNTSLITLPHIYQLGAYILAVGNLLLPSLNEFYLLIMYGIVNGVGEGLVFTSSLHIVLDSLPSRGKGVAYGIYVFFVSLSYAAGSPFSGLIADVTGFYSYSFYTAGSLEVVGSSLQFLSRFLHKNNEEKDVEHSSQNLIVTEKETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IEQ3</accession>
    <name>A0A6P8IEQ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glia maturation factor gamma-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116299932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564555.1">
        <property type="nucleotide sequence ID" value="XM_031708695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IEQ3"/>
    <dbReference type="FunCoup" id="A0A6P8IEQ3">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="GeneID" id="116299932"/>
    <dbReference type="KEGG" id="aten:116299932"/>
    <dbReference type="InParanoid" id="A0A6P8IEQ3"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="7">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031564555.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16435" checksum="61DAA6F937465E99" modified="2020-12-02" version="1">MSGSVSVCEIDPELKEKLRAFRFRKGNTSAAIIMKVQPENLLVILDEEHEDISVDNLREELPEHLPRYVAFSYVLNHDDGRVSYPLCFVFISPSGTKPELQMMYAGSKQEVVKELGFTKVFELRSVEEFTEEWLKTKLAFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF16</accession>
    <name>A0A6P8IF16_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epimerase family protein SDR39U1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565120.1">
        <property type="nucleotide sequence ID" value="XM_031709260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IF16"/>
    <dbReference type="FunCoup" id="A0A6P8IF16">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="GeneID" id="116300387"/>
    <dbReference type="KEGG" id="aten:116300387"/>
    <dbReference type="InParanoid" id="A0A6P8IF16"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05242">
        <property type="entry name" value="SDR_a8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092:SF0">
        <property type="entry name" value="EPIMERASE FAMILY PROTEIN SDR39U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092">
        <property type="entry name" value="SUGAR NUCLEOTIDE EPIMERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="2">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565120.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36381" checksum="829839227756D4A4" modified="2020-12-02" version="1">MQALWKSRIYLTKRPPKDAIQTLIRFRCLSSSNQKNMKVVIGGGTGFVGKRLKNTLKAKGYDVQIISRTKGVGKITWDEVSASGLPDCTAVVNLAGENILNPLRRWNEKYEEDIRRSRVDTTKLLAEKIAAAENPPKVFVSSSAVGYYPPSETAEYTEDTPPSDQDTLTCLCRDWEASAELPESCKTRLATVRIGVVLGKEGGIVQQTIWPFWLGVGGVVGSGNQAFPWIHVQDICDIIVFAIENDHVTGVLNGVAPEISTNRDYTNQLASALHRPAIFPVPAFMINAVFGSVRGMIMLQGQKVIPKRTLKLGYSFKFPDLKSAIENAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFD6</accession>
    <name>A0A6P8IFD6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear valosin-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116300637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565403.1">
        <property type="nucleotide sequence ID" value="XM_031709543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFD6"/>
    <dbReference type="FunCoup" id="A0A6P8IFD6">
        <property type="interactions" value="3140"/>
    </dbReference>
    <dbReference type="GeneID" id="116300637"/>
    <dbReference type="KEGG" id="aten:116300637"/>
    <dbReference type="InParanoid" id="A0A6P8IFD6"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000081">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000600">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038100">
        <property type="entry name" value="NLV2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031996">
        <property type="entry name" value="NVL2_nucleolin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16725">
        <property type="entry name" value="Nucleolin_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="340"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="665"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031565403.1"/>
        </source>
    </evidence>
    <sequence length="919" mass="101781" checksum="D92BB77A45C8AEB6" modified="2020-12-02" version="1">MNGVTRGGCSKPFNKFDRQSSNKSRGSPRGAYIMDKALLPRMKQYLSQFRKGYTPDIEEMTSHLQSRYSDYSRKKRNSFRFSVQKAFKVLNDQDNEEKHLQRLEEKFLQEKSKDFSFIPLVDDRRKENVSVEDKEGSDTSDSELSLLEEPLIETQGSNLMNQSMQSMYRLSTSRPSSEAEDNNQTENDPTGNISTPIVVIDTNLPSSTPQAIKSSSVPSTMEESTSNQQPGDKPIDISRDQDSSVINKPNTPNSQNKRKTDISDKEEVSSRPSKKRRRSRAENSNNENEINEDKPKGFTPTQSSVKFSDVGGCEETIEQVCKMLIHMCHPEVFSTLGITPPRGFLLHGPPGCGKTLLAHAIAGELELPFLKLAATEIVSGVSGESEEKVRELFNSAVTQAPCVMFIDEIDAITPKRETASKDMERRIVSQLLTCMDDLNNNSTAQVLVIGATNRPDSLDPALRRAGRFDREISMGIPDEKARERVLKVLCKQLKLSDEFSFAMLARLTPGFVGADLMALTREASMIAVNRVFKSLQNHPALEATEGTRREIQGSDDKMKEDENKTETNQEKTERSEAVNINVMQWLKDQPPLTDEQLSSLSITFDDFKEALTVVQPSAKREGFATIPDVTWNDIGALKDVREELSMAILAPVQHPDEFASLGLSHPPGILLAGPPGCGKTLLAKAIANESGINFISVKGPELLNMYVGESERAVRQVFQRARNSSPCVIFFDELDALCPRRSGSSESGVSVRVVNQLLTEMDGLEARKQVFIMAATNRPDIIDPAVMRPGRLDKVLYVGLPSSEDRKDILMTITKGGTKPVLLPEVDIEKIGFSERCNGYSGADLAALVREASMAALRECISISSLHDKQTNGPATRVDLDGIGVGNRHFDIAFDKVKPSVSNKDHVAYHQIKTSAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG30</accession>
    <name>A0A6P8IG30_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insulin receptor substrate 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein chico</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116300822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Bindings to phosphatidylinositol 3-kinase and SHP2.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565638.1">
        <property type="nucleotide sequence ID" value="XM_031709778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG30"/>
    <dbReference type="GeneID" id="116300822"/>
    <dbReference type="KEGG" id="aten:116300822"/>
    <dbReference type="InParanoid" id="A0A6P8IG30"/>
    <dbReference type="OrthoDB" id="946068at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005158">
        <property type="term" value="F:insulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01257">
        <property type="entry name" value="PH_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01204">
        <property type="entry name" value="PTB_IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039011">
        <property type="entry name" value="IRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10614:SF13">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00628">
        <property type="entry name" value="INSULINRSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="7" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="12">
        <location>
            <begin position="142"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="809"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="890"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031565638.1"/>
        </source>
    </evidence>
    <sequence length="956" mass="106630" checksum="F5BB196D9BE0E472" modified="2020-12-02" version="1">MNTTDVRKQGFLRRLKTLKRRYFVLRTSSKYGKTRLEYYESEKKFRSNAPPKRTIHLTSCFNIARKDDTKHKFVFALYTREDAFGLICETEEDLDCWLNALLTEKKNSESVTENEYSPNDGGLVKSFSSSSMKREYYSPASHVSSWPVTVKPRGLGTSKNLAGSYLLQLANHHLSLVKTPSEELAADFRLMNVRRCGHTDCFFYMEVGRSCSTGAGELWMQVDDPILAQHLHEVILLAMQNLSGESSSLSRYRCHSGGHKQRPTSLMLLSPTRSRSDTDTSLHNQSSDGPVSPSKHTEQYSPAHTKPSAMFQRLLSVGKRKTEDLSPRLFSRRTQSKSLSIDPCQGGLLDRAQSVDFSRLFSGADLQTPETPESPEKEKEIIFDMDVEPVRTSSNSSGSSARSWDQSHSYMNLVLHRMEGRDTTDEGYDSTRGGDTTPKDATTPTDNKPLHVIAPSNGESSENSRPPEDDRAQDDSEKPKLDDRTVKKDEEEEDNIHRGFNSVTDSGDGNSNEADAEQVGISPKSRSRYEDMSFNFKNLNMKGEQDDEDGNSDESETLTHLFENLTMPAQYSPKQRRTSEPVVNNSSQSQPKAVFSVDQVTSETKSSSKQRRTSEPATPSKYELRELVQIRNSPSSSPRRSKKGVSSLASTINGSIAENPDSESDSPSNSRRRRNANGSSADTSDDYVVMSLQAGSHTYVNMTPREGGPKPSEDGPTYMNFRPGETSNLSEKNTEEHSYMNFKPGDIPEESEAKAQPPSYINVIPGSLTRSESVSPRPKRKHAYENLNLNGTLKVSELESHDYMNFSPLGTAEDKGVPKTKSIPSSPRGSFGSSLSPTSGWARRIQRRESEPIPGSLLSDEETGMLFLDFSKKSKEEKELNYVSLDHSKIKKRSGGKGMTKTRPASINTLPSQKRSWDTGPKSASLEAGYAEIDFAKSQGLRQVILEHEKSKPQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGF7</accession>
    <name>A0A6P8IGF7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenosine receptor A2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116300957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565801.1">
        <property type="nucleotide sequence ID" value="XM_031709941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGF7"/>
    <dbReference type="FunCoup" id="A0A6P8IGF7">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="GeneID" id="116300957"/>
    <dbReference type="KEGG" id="aten:116300957"/>
    <dbReference type="InParanoid" id="A0A6P8IGF7"/>
    <dbReference type="OrthoDB" id="9894375at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565801.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="36278" checksum="3DD2463D9527F159" modified="2020-12-02" version="1">MENTSMNHSKPHPPCLPPDVYSLDVHRGFYSNGFILTFIIINAVLAFISSCNNFVIIYTIARTASIQVPSNILVLGLAISDFGVGILAQPAYSIFKFFEMKRFVSLYCTFGLVNSYSNWTLAPVSFFTITAITVDRFLAVHLHLRYLELVTVRKYGILLGYIWVMSVVICTCRMQLSHMSFIRVVGVFSLVFLITLNLFFLVKIFQVIRRHSIQIHAQQQSVQQSIDMPRYKKSVNTMYYVIGAFLVCYVPFTGMMAVNSDPNEKITQNKLIMMVVTETLVMLNGVLNPIIYFWRIQEIRHAAFQLFRKSFRNVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGK6</accession>
    <name>A0A6P8IGK6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116301061</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565922.1">
        <property type="nucleotide sequence ID" value="XM_031710062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IGK6"/>
    <dbReference type="GeneID" id="116301061"/>
    <dbReference type="KEGG" id="aten:116301061"/>
    <dbReference type="InParanoid" id="A0A6P8IGK6"/>
    <dbReference type="OrthoDB" id="5990060at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028264771" evidence="5">
        <location>
            <begin position="21"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="448"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="778"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="907"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="931"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="943"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031565922.1"/>
        </source>
    </evidence>
    <sequence length="969" mass="108816" checksum="E4C4EB1F3522DF2B" modified="2020-12-02" version="1">MAPKGTLLVFLVVLTIDIFCESPGDCNFDRDYCNWVNDKSDNFDWLRRSGSTPTLFTGPSKDHTSGKGFYIYNYANDASDSHKPGDKAKLLSPSMRGPKCMTFYYNMYGQYMSCFLVYIKVENSTQYLAWIKSGDRGDRWIEAQVFINETGSYQVVLEVIQNWSWSGHGAIDDISFHNGSCEQNDDIFYVSKKYDTEVLYKVGTMPQYGDWKNQFSFTARKTTGALGEPMHFIYPSSSYGYPLITSTLRLEIRRFPLDFFYDSALINTSSVFYVLQRGGSMSEQISTVNSSYEHCCSLQGINSFNAVPVEDNIASKLPVNSSSATSMAFLAVDGNPDTCYYSRKSSNPWLSITLPKTAYVHRVKITNYKGCCNIPYASMEVTVERTLNAVVAISKQCGNNQPFSGDVLSRQFKCRPPIFGSRVFIRLHGDNVTLVLCRVTVAAFDSVDEAKGVHRQIWYKLINTQGMSSIRENIAFNSVPHGATLSRDFGSQFEVADNYGEMLTSFLQVPLSGNYTFHLSCGDECELWINEFHENGLLFDKGSINSDVGQLLVRIQKWASYNDSLGCVTASTTSKIYLTKCRIYEMKLYVKEGSSFQCLAVGMTTPNGNIEHPIKNKYLFWMQPGQRILTFTMLGPTVLEADLGETVSIKARYTFCCHGIHCPNCSLTVDFHVFGKVFDVSRSLKATCEEHLFSVQLDAVVQPGIHEMKILYTFTGTPKKEKGQRTVGQINVKVAVLQNETFTKGFGKWSTDSQPSWKTDNSSDELYAFIDGPYSSNLESPVLPWKQFYSQVGLCIDFSYLMPKPKPATLKIFLNITGIKSQLLWSLSGFHGNKWKRARVSWQAKENSLIVIRGESSVNAISVAIDTVTITTEACKVRPSYAFPGFTCNKDEFQCANGHCISNNQRCDNDFNCLDNSDEIGCKCLVNELTCPSGKCVKSRNLCDGTKDCENGLDEKRCGKEVNTRKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHD7</accession>
    <name>A0A6P8IHD7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Testin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116301241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566134.1">
        <property type="nucleotide sequence ID" value="XM_031710274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHD7"/>
    <dbReference type="GeneID" id="116301241"/>
    <dbReference type="KEGG" id="aten:116301241"/>
    <dbReference type="InParanoid" id="A0A6P8IHD7"/>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09340">
        <property type="entry name" value="LIM1_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09345">
        <property type="entry name" value="LIM2_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09341">
        <property type="entry name" value="LIM2_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09830">
        <property type="entry name" value="PET_LIMPETin_LIM-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF37">
        <property type="entry name" value="PROTEIN ESPINAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="7">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="316"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="438"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="498"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031566134.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="62982" checksum="D9B27066CD380832" modified="2020-12-02" version="1">MSETDFQILSFIHFKGSDKSKEPLTAEDLEGNTCLLCENGCEGFSTHSWRKFCNSCKCSQELHVKTLNNNEHNEPKDRMCVEEENPPILSGSDLEQAALEGFEWVPRGLDSEQIHQYMSLLPGDKVPKLNSVGAKYRRKQLALQLPLQDFSSKHCKKLTLEQKMAMEDFNEKRLKNALGIGSVRPSITEDATCSKCKDTISAAEMAIFAERAGPEFCWHVPCFVCEEDGELLVDLVYCFKDGALYCPRHWGESQKPRCAGCEELIYVGEYSQAIEKNWHPGHLCCSFCDESLSNQKFVTVEGRPSCFKCYDLNFANTCESCKEPIGPGSKDVDVRNKHWHEDCFKCSQCNKQLLSEGFTFKDEKLICHACRGINPSKVCAHCGGDFAPGEKKVGYQNKTFHDRCFICDECKEPIGSKQFIRRDDKRLCNNCFDSKFAKVCFKCKEVIRTSSVQHSGNVYHSECFICYHCNNPLAGKPFTKQEGNNVCQDCYRERYAKRCAACDKLIEGNTKFVAYSEKYFHRDCFTCSKCEKPLAGEKFRIRDEQKVCLSCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIE9</accession>
    <name>A0A6P8IIE9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ethanolamine kinase</fullName>
            <ecNumber evidence="5">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116301567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031566504.1">
        <property type="nucleotide sequence ID" value="XM_031710644.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IIE9">
        <property type="interactions" value="2626"/>
    </dbReference>
    <dbReference type="GeneID" id="116301567"/>
    <dbReference type="KEGG" id="aten:116301567"/>
    <dbReference type="InParanoid" id="A0A6P8IIE9"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031566504.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40382" checksum="4DEBC83A611ACE1E" modified="2020-12-02" version="1">MGPPHFNMKLDKDNPEAGIKEIMKKLRPDLDPNELELVEFNEGISNKLVGCRKXGTPRKDIILFRLYGNKTELFIDRKRELETFKILHSRGYGAPVYATFDNGISYGFIEGEVLDTVTIADDHISTLIAKHMAELHAIPPKGRGKPTSSLFKTIYKFLNLVPADFPDQTKNQRFQKECLSKAKLIEEAARLQGVLEKHDCPVVFCHNDMLCKNIVFNKEEDKVYTIDYEYANFNPLAHDIGNHFCEYAGVEEVDYSLYPKKDHQLKWLRTYLTRSAELKGESNPKITDKEVXKLYVQANQFALAAHFFWGIWALLQAHFSEIDFDFLGYGIIRFNEYFKRKDEFLALGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIY8</accession>
    <name>A0A6P8IIY8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cotranscriptional regulator FAM172A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031566757.1">
        <property type="nucleotide sequence ID" value="XM_031710897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIY8"/>
    <dbReference type="FunCoup" id="A0A6P8IIY8">
        <property type="interactions" value="3013"/>
    </dbReference>
    <dbReference type="GeneID" id="116301780"/>
    <dbReference type="KEGG" id="aten:116301780"/>
    <dbReference type="InParanoid" id="A0A6P8IIY8"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566757.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52126" checksum="C30566031C706134" modified="2020-12-02" version="1">MAMGNSNTNTKRTLEEAMSKERLSIEEYGYEFQEVNDQHKLRDIKTGKNFKFDVYREKELNQQRYEEIGEAITEYVYEHLEKMLKLKRVHIPVLPADAGPNEPKGFFFMSENALKSDKLMILIHGSGVVRAGQWARSLIINNSFEAGTMVPYIERAKEEGFGVLITNGNHNYDEKLHKCIKGSENPQDHFVYVWNNFIKKAKAKHIVIVAHSFGGVVVLHGLRNIKEAKERIKAVAFTDSVHSVGHYESSDIKQFFKERTRNWVSSREPLDTPIRSYYKDDTCELVSAGTTEHVWTSHCAKDSVFSFFKEKLDKEEKGKDNDKCAGNGSRCGSDDCEEDDQEGLKGDEQQLETGPEDGKMEKENSKDEGSENDNMVTGDDPIAGTPGEETVQQGKDNMVTGDGLITGTPGEESVQPGKDNMLTGDGSITGTPGEESVQQEKDNMVTGDGSITGTPREETVQQEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJ13</accession>
    <name>A0A6P8IJ13_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Syndetin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116301799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566777.1">
        <property type="nucleotide sequence ID" value="XM_031710917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJ13"/>
    <dbReference type="FunCoup" id="A0A6P8IJ13">
        <property type="interactions" value="2285"/>
    </dbReference>
    <dbReference type="GeneID" id="116301799"/>
    <dbReference type="KEGG" id="aten:116301799"/>
    <dbReference type="InParanoid" id="A0A6P8IJ13"/>
    <dbReference type="OrthoDB" id="10263345at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="53"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="5">
        <location>
            <begin position="719"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031566777.1"/>
        </source>
    </evidence>
    <sequence length="961" mass="112108" checksum="3C0746403C687904" modified="2020-12-02" version="1">MAFRIRFRSLLGLDRSSRESADGEFSDGTADSVFKEDTCREFDDDPRTDDEVLETIEEVYFSDTKFDPSDYELKKATEKELVLEDVEEYRNTLRQQLQSVSKKLYTKVLENHSAYVQELQRVMELQEALQNASSICDRGRRHLDKARRGVSVGGLGILAKHRKKQHLITLLDSLRTIKTLQRTDVRLKEMLEEEDYPGAITLCLECEKAARAFKHYECISELSSNLQETLIDIEKQLDLALVRICNNFDPAYYERLQTAYRYLGKTQISMDQLIIHFMNHINQVSFSVILDHVEDDPPEYVAEDGLQHVHFGELCKKVQTQHFTPCLMGLCKVLWSVMLNYHKVIRWHEQYDPAMHVTESDVTDGNKDDEKTAEATYNRNYIRQKLDHGLNRIWKEVQERIKTHLLGTDLSYFKYDDFIFVLDLVNRLISVGEEFCGSKSEDLNESIRKQSVKYFKNYHRSRMEELRMFLENEAWQLCPVKASFKIMDLQEFRFMKHQQIPLIKTHRRTASGNMNVTTETGFFSRYATQGNPFDDVYVEDEGEDVMAQNGLDGDDGNNDDEEDDDDEDIADELKLDYVDEKTGEIPAGRSDGYLLSRKHQRFLSRVPCITNTTLNVLRVFGKYMQMMNVLKPIAFDVVICMSQLFDYYLYAVTSFFSPEVLVDGSTHGLSIKLRTTLKRISDNLILSPEQEMNMEAPADDMKVPHPHLSPMVDLQIHNMYGLPERILATESLVFLANQFEFLQSHLDSMIPQNKRAFLSQFYSQTVTTVQEIRKPTYRAVAARVIDYEKTLQLMQGVRWDIKDIMSQHNTYVDILVREFQVFSMKMTQLSKRIPVPKEVYVVLWDHCVRLANRTFVEGFASAKKCSNEGRALMQLDFQQYLMKLEKLTDIRPIPDREYVETYVKAFYLTENEMERWIREHKEYSSKHVTSLVTCGVGSHITKKGRQKLLAIIEEIEKNKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJB9</accession>
    <name>A0A6P8IJB9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116301875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566899.1">
        <property type="nucleotide sequence ID" value="XM_031711039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJB9"/>
    <dbReference type="FunCoup" id="A0A6P8IJB9">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="GeneID" id="116301875"/>
    <dbReference type="KEGG" id="aten:116301875"/>
    <dbReference type="InParanoid" id="A0A6P8IJB9"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="178"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031566899.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="43505" checksum="6F52A2BC241648EC" modified="2020-12-02" version="1">MDERGLQTLKEIASKAIDNIEKELFDLNQKIWKTPELGFEEKFAHSALTDFLEKAGFEVSRGFGGLDTAFRAVSGKSHKLSVGILCEYDALPGIGHACGHNLISEAGVGAAIGLKAALEAAGIELGRVVVQGTPAEEGGGGKIIMINNGCFDDLDICMMVHPKPFNCIYPTCLARREVTVTYNGYAAHAAAFPWEGINALDAAIMAYNSVSVMRQQMKPTWRVHGILTNGGVKPNIIPDKTSLLYYIRTPTESEMDILRDKVQLCFEAAAKATGCSVNMVWSELSYSNVTTNEILGKLYQENAEQFGLTFPPRSEQEKAAVGSTDMGNVSHVKPSIHPYFDIDTAEPNHTEAFTAASGRKEAHRMTLIQCKVLASVALDVMCKKGLIKEVQDDFDRAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK36</accession>
    <name>A0A6P8IK36_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567286.1">
        <property type="nucleotide sequence ID" value="XM_031711426.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IK36">
        <property type="interactions" value="2772"/>
    </dbReference>
    <dbReference type="GeneID" id="116302197"/>
    <dbReference type="KEGG" id="aten:116302197"/>
    <dbReference type="InParanoid" id="A0A6P8IK36"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045576">
        <property type="entry name" value="RPC5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19725">
        <property type="entry name" value="RPC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC5 C-terminal" evidence="2">
        <location>
            <begin position="459"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031567286.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="72997" checksum="F92FFC51B0584444" modified="2020-12-02" version="1">MADEEXEDPVVAEVDVFLAKSLAENLYIFQYPVRPAELSYDNVPHVGARIKPRQQKVEIELAINTASRNYYQPRGEQIAIDVNGRVPADSERYYESERMDKQVLVSSRASAEATRYAAGVLREGELHITPLQGVLQLRPNFEYMNKAETNVTQAASTQDEDSQDEEEEPAKALTLRFARPESDKAKAQRLSSYKYLEQKEAEEEWKNLQYYQPQHSMASLDREKLFCADCNVEAPEITLSSKEYLKSLMPSSTKQESTLPSKMPRNVLSMTQLRTMDLPDQVKALLRNAKVMSFSQLCTLLSPVGKEAAVLKCVQQFGVLVQGCWLVKSEILYPEKSVSPNSGIPSEILCRGRDYIMWRFTHSRVVVRKDIATVTKLPNDDIKEILEQMARMRVAQGWEFILPCDTEFIHKHPDVVKQQNIFWENKKELLASQLNLNKIHEKDHKKSTGSDSSHGPEIKKTSKNPKTTANHVVKEETTSDMNGNATEITRSVSPMEVDCKEVNLDEQMDGLSTSAPLSEDSEFFEEAFKKLQDFVCEKLHTTVLSFKEFKRLLLLRQTACEPGDVLCSGVSDALLEDVISSTGAQEIQIKWPTSSLNKDIQSRRFFAFRKVGDNSMDKFREILLDMFASHHSIKKADFQART</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILR2</accession>
    <name>A0A6P8ILR2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Alpha-ketoglutarate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC116302567</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031567759.1">
        <property type="nucleotide sequence ID" value="XM_031711899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ILR2"/>
    <dbReference type="FunCoup" id="A0A6P8ILR2">
        <property type="interactions" value="1700"/>
    </dbReference>
    <dbReference type="GeneID" id="116302567"/>
    <dbReference type="KEGG" id="aten:116302567"/>
    <dbReference type="InParanoid" id="A0A6P8ILR2"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase e1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="638"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="978"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031567759.1"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112978" checksum="B9DA231305D20D47" modified="2020-12-02" version="1">MYAIRTYRNILKGCLRSTWGKGLMAIRPQQTAAVVAKEPFLNGNSSNYVEDMYASWLENPKSVHKSWDAYFRNVKGGMPPGQAYQPPPVLGQQTGALASTVSVPSAVDQSKINSLVNDHLAVYSLIRSYQTRGHRKAKLDPLGILQAGLSEDVPVDLQMEYWGLGSQDLNKVFQLPNTTFIGGENIQAMTLGEIVNKLEDTYCNHIGLDFMFIPEKYKCDWIRKKFETPGMNALSKEEKRTLLARIVRSTGFEAFLARKWSSEKRFGLEGCEVLVPAMKTIIDLSSELGVESVVMGMPHRGRLDVLANVCRKPLEQIFTQFDPTLEASDEGSGDVKYHLGMSHERLNRATNKIIRMAVVANPSHLEAVDPVVQGKTRAEQFYRGDAQGKKVMSILLHGDAAFSGQGVVYETFHLSALPHYTTNGTIHIVVNNQIGFTTDPRYARSSPYCTDVAKVVDAPIFHVNADDPEAVVHVCKVAAEWRAEFNKDVVIDLVCYRRNGHNEGDNPMFTQPLMYHRIAKQEQVLNLYSKKLIEEGVVTKEEVQEEIAKYEKICEEAYFEAKSDRKQLRNKDWLDSPWKGFFPKNYEMTPIKPTGISLDKLKHIGKVMSTPPEGDFKTHGGLKRILRGRAELLEKGYVDWAMGEALAFGSLLLDGIHVRLSGQDVERGTFSHRHHILHCQLKDKLLYCPLNDLSEEQAIYTVCNSSLSEYAVLGFELGFSMTNPYALICWEAQFGDFMNTAQCIIDQFISSGQDKWVRQTGLVLLLPHGYEGMGPEHSSARPERFLQMSNDDPDYFPPEGELFEVNQLHSANWQVVNCSTPANYYHVLRRQMAMDVRKPLIIFTPKSLLRLEAARSHIDEMIGDKSFQRIIPDNGPASSNPEKVRKLLLCTGKIYYELLKERNKRGLDEDIAITRVEQISPFPLDLIKAEHIKYDNAKIVWAQEEPKNMGYWAYVKPRIETAVNKQVEVSYAGRSTAASTATGNKHQHISEQENLIDEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM00</accession>
    <name>A0A6P8IM00_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116302620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567817.1">
        <property type="nucleotide sequence ID" value="XM_031711957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM00"/>
    <dbReference type="FunCoup" id="A0A6P8IM00">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="GeneID" id="116302620"/>
    <dbReference type="KEGG" id="aten:116302620"/>
    <dbReference type="InParanoid" id="A0A6P8IM00"/>
    <dbReference type="OrthoDB" id="5972199at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016849">
        <property type="term" value="F:phosphorus-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04759">
        <property type="entry name" value="Rib_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.82.10">
        <property type="entry name" value="ADP Ribosyl Cyclase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF7">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027893944" evidence="7">
        <location>
            <begin position="28"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031567817.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37952" checksum="96DC0DFC124BF0DE" modified="2020-12-02" version="1">MTTFSLIQMAFFALISVFLALITVARTDSGINPGSTLNLRDIVIGRCDDYLRKNEKLRPKDCTAIWEKFRDVFAFKDVCQLTPSDYQPFFDAVEEGVINNKAMFWSGTYKAAHSYSFFDLTFTTLEDTFAGSMMNDLRWCGNPSLPPNTTDGIDYKSCPSCFKYNKFFWIQASITFAERVRGQARVMVNGTRISQPAYSNKSIFGKYELPNLKVADITKLFVIVLHTIGKKPIEKCGTKSIKKLEADATALGLNVHCENDPDMARHVLCIDHPKANECRFHDENQEPVETYWKILGIIFVVLFSVLLIVLIVLVALYFCRKKGSSTRAHLLQPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMP1</accession>
    <name>A0A6P8IMP1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116302627</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116302627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567825.1">
        <property type="nucleotide sequence ID" value="XM_031711965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMP1"/>
    <dbReference type="GeneID" id="116302627"/>
    <dbReference type="KEGG" id="aten:116302627"/>
    <dbReference type="InParanoid" id="A0A6P8IMP1"/>
    <dbReference type="OrthoDB" id="10288515at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028126039" evidence="4">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031567825.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48913" checksum="3E6FEAA6371030E1" modified="2020-12-02" version="1">MVFMLFVQSPLPHGIFYFILTVLMVDTTSSATVAQNGRISPCKAPCTEYGIVATARLERIDLKIYKVVRRAEDEIAKASDVRQVVASPGQWQINITAILYEPQTFDPILKALVESAKKVIPVNNRFSTPFFFLVLQSEKGVYGEALNAMSLRVIGFLNNLNNHPFLPPSKRSIAIIHERSEILFKWLTVNFLAGYFDQEKSHSKVGVLGLSLNTVTQIAYPVHSTSMNTTEFVTIGTMPYLLIAQSYTTEGFGTTLREYFTKLGQVQGQGKQTSPCSPQGAQVQVVDGDIVKQYIGNGNVQQCLKILNDVILNDYGRWTRSPYIRKPPKYIKFYALPQVVNVLNEIGCLGCEKVFTPAKINAAARLSCSSSQPRNGDLPSTKNCLNANFFYLMLTESYHFEDNTPITVLPKSVHGIDEDWALGALLYKLRLLSYKIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IMY4</accession>
    <name>A0A6P8IMY4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116302695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567905.1">
        <property type="nucleotide sequence ID" value="XM_031712045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IMY4"/>
    <dbReference type="GeneID" id="116302695"/>
    <dbReference type="KEGG" id="aten:116302695"/>
    <dbReference type="InParanoid" id="A0A6P8IMY4"/>
    <dbReference type="OrthoDB" id="10427246at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031567905.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27735" checksum="9036C2083F8732E1" modified="2020-12-02" version="1">MKVFRVICITPCRIITENVVRRLTWQNFTVTDKPNKPVRFAAACQVKHPTFMDQNRKGTRKDTPAHVQMPSPFRRQVRNMPLETKLEEEEKDCQNEVIIKENHDNQSVPRSKETGQTQRTRKPTPAYVQRQVSKKGKQKSVSFDEELLEEEEDEAKQKLTGDFIDIAKHPILRKDTPAVLTNPKSKTKARTLSNQGSITEEEENEDDFDETLMSYRLRKQSILQCSHPSIEEVSLKDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INB1</accession>
    <name>A0A6P8INB1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116302999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031568302.1">
        <property type="nucleotide sequence ID" value="XM_031712442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8INB1"/>
    <dbReference type="FunCoup" id="A0A6P8INB1">
        <property type="interactions" value="1974"/>
    </dbReference>
    <dbReference type="GeneID" id="116302999"/>
    <dbReference type="KEGG" id="aten:116302999"/>
    <dbReference type="InParanoid" id="A0A6P8INB1"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031568302.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18954" checksum="152AE23D9BA29A47" modified="2020-12-02" version="1">MAAEMTSNLEEEALKRKEKLRAMRQKSGVTGDQQPEQTRGEKRQAEETSEPIKVIKFRNYVPKDETLKDKKLPDAKPLSVEDEVKEHLEKAKSTNIIEEVDLTNLAPRKPDWDLKRDVAKKLEKLERRTQRAIVELIRERLQDSEKEDLAAAVNAASTDQGFESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IP81</accession>
    <name>A0A6P8IP81_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC116303309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116303309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568694.1">
        <property type="nucleotide sequence ID" value="XM_031712834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IP81"/>
    <dbReference type="GeneID" id="116303309"/>
    <dbReference type="KEGG" id="aten:116303309"/>
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    <dbReference type="OrthoDB" id="5955890at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="104"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="439"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031568694.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="54254" checksum="CCC02B65F51CBF63" modified="2020-12-02" version="1">MAGSVQLANGARCICGNNDATKFRHYLDRDRDHEHLGSFCLKCEREYVKAEFILDDVKKDEANVLELGKEEFYQAERLDTTDGVHFVHPRKTKIERLDLFGDYLKPGDHIAWERPYIIWHHALVLDIDVANGKVQVIHWHGEGISKTGAIIQEQWIHLKQESGILYRMDYEEDILKENPLRLVIARARSRLGDVGYRFFGDNCEAFVTFCKKGIKKSQQVVALMKLVSDQVKMVLGNIPTKIVTKGLAKASFENIGKVGSAEAMEKVAKNCQWVGFGLVVIIEGCLTIYDLKKLYDARKDGSLSGNEFMEQVSKRVTEALCAGVPAAFGGLVAGWGGIFVGIICGTVGKLIGSQIGKYVGREITRVIRPNDRAVASIKDLHLGDQIVFYGTIVHPRHHCIVLWHEEEESKVNVIHNTYEFGVTQEWVNFVPPFYKVSYHEKECYPPNEVCSRAISKLGTNDYNLLTYNCKHFAEWCKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IS86</accession>
    <name>A0A6P8IS86_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B-cell lymphoma 3 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116304204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569757.1">
        <property type="nucleotide sequence ID" value="XM_031713897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IS86"/>
    <dbReference type="FunCoup" id="A0A6P8IS86">
        <property type="interactions" value="801"/>
    </dbReference>
    <dbReference type="GeneID" id="116304204"/>
    <dbReference type="KEGG" id="aten:116304204"/>
    <dbReference type="InParanoid" id="A0A6P8IS86"/>
    <dbReference type="OrthoDB" id="5982935at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF2">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031569757.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46150" checksum="875D7260E0C7FAE5" modified="2020-12-02" version="1">MVNSSSEGDVCKSLSDKEPYLTLNPKQLEELSTSGFSEERRSLKESIRKKLTARVFPMTRDTRNHIENSQGIISGNLQKRPSSEGVLVHSSGVDSTIIERRDSVIKTEKPDISVSKASRELEKVNYRKHKIYKDNHLEPQSKQIRIYSPNSLPQQDNTLSMRRTPVTSEPRLLGDNVATLSLLTASQGHLATLQDDDGDTPLHIAIAQGQVPLVQYLIHIASTSGISLDIYNKMKQTPLHLAVITNQPLVIRFLIAAGVDINMPDRNGQTAIHLACQRSSVECLMELVNSHMAINLELKNFNGFTPLHEAVISNSPEVIKFLVAYGANVDCKDGKGGRTPLHYAVELELLPVIQLLMNSGANVNAGSFSGNTPIQTASGRGLHHVTKLLLGNLQEASGRESRHESSRYKLKSTSTWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISY7</accession>
    <name>A0A6P8ISY7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303917</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569400.1">
        <property type="nucleotide sequence ID" value="XM_031713540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISY7"/>
    <dbReference type="GeneID" id="116303917"/>
    <dbReference type="KEGG" id="aten:116303917"/>
    <dbReference type="InParanoid" id="A0A6P8ISY7"/>
    <dbReference type="OrthoDB" id="10282873at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027671200" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569400.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16836" checksum="F0B15949F5996D65" modified="2020-12-02" version="1">MKLLFLLLGSLAVLVTSSQPDDQNDVIRLIKVWGLNEHHGHRDKGPFKECVKGFKECVSSGIGGLADEQSCRMGFCDCRKNVCQAYFKSCGSNSWCSFNDICFKSSAACRSEPKKESKCRRSLMKCLKRSSMDKTRTYECMKMFNDCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT01</accession>
    <name>A0A6P8IT01_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569410.1">
        <property type="nucleotide sequence ID" value="XM_031713550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303925"/>
    <dbReference type="KEGG" id="aten:116303925"/>
    <dbReference type="InParanoid" id="A0A6P8IT01"/>
    <dbReference type="OrthoDB" id="5986356at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028265662" evidence="1">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569410.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34968" checksum="AFA67B8ACA88DDB9" modified="2020-12-02" version="1">MKQSIAVILLFAFVAQIYATNELDAYLTEDMEDDSDRHPYVQCKIDLYDCMRKGAQSKTECLKAYYNCMKQLVPTVPPFVVQCKDELKNCVATATGFVNKGKCFVEFAKCLKNGGPSSPSTFLMDDVVPDRHPYVQCKIDLYDCIRLKKKSRMECLKDYKSCMSVLIPTVPPFVIACKDELKSCVSGASSILDKAVCFRDFGKCLINKGPSPTAFDAGEFVLNAMEDGSAPTRHPYFQCKIDLYKCXKEGQKGKLQCLKDYKSCMAQLIPTVPPFLVKCRDDLKTCLSSSDGWKAKAQCFVDFGKCIKNKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITB8</accession>
    <name>A0A6P8ITB8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetylcholine receptor subunit beta-type acr-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031570456.1">
        <property type="nucleotide sequence ID" value="XM_031714596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITB8"/>
    <dbReference type="GeneID" id="116304810"/>
    <dbReference type="KEGG" id="aten:116304810"/>
    <dbReference type="InParanoid" id="A0A6P8ITB8"/>
    <dbReference type="OrthoDB" id="5980697at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027953865" evidence="6">
        <location>
            <begin position="22"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570456.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32256" checksum="AD0D221A932E8881" modified="2020-12-02" version="1">MMKLITRLVVVFLIQLKAVEGQKLDHNLHQVKIRKEKLQDYDRIIGPVEYRERRVLSVTFSLSITRLVYADTKKQTLTLEAWEVKAWNDEYLKWKPKNFGGVGRTIFAPDEIWVPDIMLYNSANSPDSLNNLPTKHVTNVYVKNSGDCLWFTPKTYTSNCMMNVKYWPIDEQVCTLTFGSWTYFDHEMKIEPLTLTENDTDTVLPSNGEWEIKSIKYVTGKTDHSNCCDGNYSTISYHITIARKPAHLLFYLTPPSVILGILTLMSFFIPTESGERIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITI2</accession>
    <name>A0A6P8ITI2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex protein DDB_G0274915-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570526.1">
        <property type="nucleotide sequence ID" value="XM_031714666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITI2"/>
    <dbReference type="GeneID" id="116304878"/>
    <dbReference type="KEGG" id="aten:116304878"/>
    <dbReference type="InParanoid" id="A0A6P8ITI2"/>
    <dbReference type="OrthoDB" id="5835755at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570526.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="29748" checksum="5F6BC31CC841E4CB" modified="2020-12-02" version="1">MSRDEAFSKKIALNRYPDPKNGNNTTGIFGTIFSSTTGIFGTILSSTTGIFGSILSSTTGIFGTILSSTIGIFGTILSSTIVIFGSILSSTIVIFGTIFFSTIVIFGFILCSTIGIFGTIFFCTIVIFGTIFSSTIRIFGTISFSTIGIFGTILSGTIGIFGTISFSTIVIFGTISFSTIVIFGTISFSTIGIFGSISPSTIGIFGTIFSSTIVIFGTIFSSTLVIFGTILSSTIGIFGTILSSTIGIFGTILSSTIVIFGSIFTQYYRDIWYHFIQYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUI0</accession>
    <name>A0A6P8IUI0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304247</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031569813.1">
        <property type="nucleotide sequence ID" value="XM_031713953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUI0"/>
    <dbReference type="GeneID" id="116304247"/>
    <dbReference type="KEGG" id="aten:116304247"/>
    <dbReference type="InParanoid" id="A0A6P8IUI0"/>
    <dbReference type="OrthoDB" id="6056409at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569813.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50779" checksum="87DA961650F03ABB" modified="2020-12-02" version="1">MGAAGSCGSGKEVSDQIPSFKIVLVGDPEVGKTSIFLRFIKNQFDYSYQPSISVSIGNVVRKVNIPYEAIVSVTLWDLPGREEMDLRKSYYKDVDAAMVVVDMDDLDSITMAGTWKQDIVNNATYSDKHDFQGISNTQNKNLQNERKEVRSLPILLVGNKVDKLKMISEVESQEEDLPMEVFKILEQVATQHGFVGSVTVSAKESDGSVHAAIQSLVRHMLQQRRQQKKGIFSGDKTIEEKKFVTLSPFEEEKKEFVPLLVVKISEFDVFFKDCNESIERVENTSMALIEAMANFKRACSVAGVTNSTKASLEECIGGLKELIRTDDDEDGLEVHDDGCYLKLIIKEDEVKNVSGPVERVLRTFHNELCTASKKVLIQGPGLHNKLKEIEEKISTLRVSAFDRAMDAGLSQRRAKAALANIDANCNRIREAVAMAMESMSAVESDYKKIKAAMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUX3</accession>
    <name>A0A6P8IUX3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116304389</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031569975.1">
        <property type="nucleotide sequence ID" value="XM_031714115.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IUX3">
        <property type="interactions" value="1613"/>
    </dbReference>
    <dbReference type="GeneID" id="116304389"/>
    <dbReference type="KEGG" id="aten:116304389"/>
    <dbReference type="InParanoid" id="A0A6P8IUX3"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10361">
        <property type="entry name" value="SH2_Fps_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000212">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035849">
        <property type="entry name" value="Fes/Fps/Fer_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016250">
        <property type="entry name" value="Tyr-prot_kinase_Fes/Fps"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000632">
        <property type="entry name" value="TyrPK_fps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="F-BAR" evidence="19">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="17">
        <location>
            <begin position="501"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="609"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="449"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="315"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="731"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="615"/>
            <end position="623"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000632-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000632-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031569975.1"/>
        </source>
    </evidence>
    <sequence length="870" mass="99748" checksum="A11503F653CE4B4A" modified="2020-12-02" version="1">MTMSSGNQRHRFAVELLSKSGHEAIVKLNENEIKLLENMKHYMTKRIKVELDYSAALSKINASATQGMPDGDPESLVRKAWSTYIKESDQKALLINQFSTHISTNTFAKLEQLIQDKKNLLKRYKTXRFRVDSEYKQESDEIDRLRRTYRENAKDSESGKSKYEEVITKEKATPKEWDKSKDKFVKSTLKLHQNHNDYVLSLLSANEHQEHYVNGIVPTMLNFLQDIQESYVSEWKEVLKDFDAFTDGCREEYLTSSKNIHDAIDQVDQSTEYTSFVLENKKSCPMCPFIFEPTLIEQVSTQLEPDKLILNDLTCEKLMHKKTLLSQELQIIEQQLEHKKRDLKIEMDNLKEAKEDGREVLCIVQRQVTVAAVSWQYEEMKCSQAKLQKKLSTVSELIDKLGNDLPPKFYDLIGAPNTVTAVGDFNQSSPQVRRSIRTLKFGLPFPKKKTGKLSSISDSKNSLSSDEQKRTDPDGTAGDSDSIVGEYEEPPDDVPLEEQEWFHGVIPRKECDKRLLNNGDYLVRESATKPGEFVLSAKDSGHLRHFIIQKTEEGFVRFEDHAFPSFRELLQYHVLHRAPVTKKSNAIITTPISRPQKQKDKWDLSHDSIQITTKLGHGHFGDVMKGILKPQNTPVAVKSCKENVSDLVKQKFLAEAEILKQYNHPNIVKLIGVCADREPVYIVMELMPGGDFLSYLRKHSGQLQIPKLVRFSIHASSGMEYLASKNCIHRDLAARNCLIGDRDTLKISDFGMSREVLDEGLYEASNMREIPVKWTAPEALNYAQYTTLSDIWSFGILLWETFSSGNTPYPGLSNKDTRDKVEQGYRMPPPLGTPPSIYKIMKDCWNIEPEQRPKFSDILRRLKQIESTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUY9</accession>
    <name>A0A6P8IUY9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ferrochelatase</fullName>
            <ecNumber evidence="13">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116304400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:22586"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031569990.1">
        <property type="nucleotide sequence ID" value="XM_031714130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUY9"/>
    <dbReference type="FunCoup" id="A0A6P8IUY9">
        <property type="interactions" value="1370"/>
    </dbReference>
    <dbReference type="GeneID" id="116304400"/>
    <dbReference type="KEGG" id="aten:116304400"/>
    <dbReference type="InParanoid" id="A0A6P8IUY9"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031569990.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46064" checksum="C9ADB3BD150510A9" modified="2020-12-02" version="1">MALFLRQISRACGSRLQLSPSYNNLAIVSSVLKDARHGSIRNSSSSSTAKPKTGIMLLNLGGPENLDDVHDFLLRLFMDKDLIPLPAQNQLAPWIAKRRTPKIQEQYRKIGGGSPIKMWTEKQGQGMVELLDKMSPSTAPHKYYVGFRYAKPLTEDTIEQMEKDGIERAIAFTQYPQYSCSTTGSSINAIFRHYNKRSSESKMTWSTIDRWPTHPGLVKTFTDNIKSELEQFPEDVRKDVIILFSAHSLPMSVVNRGDPYPQEVAATVQRVMEALNFSHPYRLVWQSKVGPLPWLGPQTEDAIKGLAKNGKKSLLLVPIAFTSDHIETLHELDIEYAQDVAKEAGIEHIRRADSLNDNPTFIQAMADIVLDHLHSNQPCSRQMTLRCPMCVNAVCGPAKEFFANQKVVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IWJ3</accession>
    <name>A0A6P8IWJ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116305620</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571427.1">
        <property type="nucleotide sequence ID" value="XM_031715567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IWJ3"/>
    <dbReference type="GeneID" id="116305620"/>
    <dbReference type="KEGG" id="aten:116305620"/>
    <dbReference type="InParanoid" id="A0A6P8IWJ3"/>
    <dbReference type="OrthoDB" id="8963357at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571427.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22881" checksum="1A8A0163BBE2309B" modified="2020-12-02" version="1">MYTRNKFMKNQSILVMKCNTMPILVDHPTMRILVNHPTMCILVHHPTMCILVYHPTMCILVYHPTMCILVHHLTMRILVNHPTMRILVNHPTMCILANHPTMCILANHPTMYPTMHILANHPIMCILVYHPTMCILVHDPTMCILVNHPTMCILVNHPTMRILVDHPIIIIAQEDNRNKTNTFIPYNRQTKSYEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXV6</accession>
    <name>A0A6P8IXV6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116306359</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031572266.1">
        <property type="nucleotide sequence ID" value="XM_031716406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IXV6"/>
    <dbReference type="FunCoup" id="A0A6P8IXV6">
        <property type="interactions" value="947"/>
    </dbReference>
    <dbReference type="GeneID" id="116306359"/>
    <dbReference type="KEGG" id="aten:116306359"/>
    <dbReference type="InParanoid" id="A0A6P8IXV6"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="104"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031572266.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="50982" checksum="79F2451F62033539" modified="2020-12-02" version="1">MAYTTWILRSVLQRTAPRVLRSRIIPHFRTLPKFLSTSFSTPEYNEKPRFPGALNCEFTEKIEFVDPSDPRGIIPVYRVMDRRGTIIDEGHDPKLDKDMIIDMYKKMTLLNTMDRVLYESQRQGRISFYMTAYGEEATHFGSAAGLHSEDLIMGQYREAGVLMWRGFGLADFMNQCYANMHDVGKGRQMPVHYGSKEHNFVTISSTLATQMPQASGAAYAYKRLGKPNCVVCYFGDGAASEGDAHAAMNFAATLDAPVLFFCRNNGYAISTPTHDQYRGDGIACRGRSYGMLAIRVDGNDVFAVYNVTKKARDIAVKESRPVLVEAMTYRIGHHSTSDDSSVYRSLKEVNYWDKEDHPISRLRYYLENKGWWDQNQEQDWKKEARLQVMKAFSEAEKALKPSVKELFYDVYKELPKHLEEQYKECLEQIAKYPHEYPTEAHAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYH9</accession>
    <name>A0A6P8IYH9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116306328</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572224.1">
        <property type="nucleotide sequence ID" value="XM_031716364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306328"/>
    <dbReference type="KEGG" id="aten:116306328"/>
    <dbReference type="InParanoid" id="A0A6P8IYH9"/>
    <dbReference type="OrthoDB" id="10270341at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028403192" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572224.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11429" checksum="4F0C4593909114A9" modified="2020-12-02" version="1">MNAWVTFAVLLCCLAVTTAFYRKRSDNCADKYPREKCQQFVSQDXCHTEDARVNCGVTCEACGKACTDWHSRCSEGDVKDQLCADDAPAFMICARSCGLCIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZD2</accession>
    <name>A0A6P8IZD2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 189-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572549.1">
        <property type="nucleotide sequence ID" value="XM_031716689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZD2"/>
    <dbReference type="FunCoup" id="A0A6P8IZD2">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="116306606"/>
    <dbReference type="KEGG" id="aten:116306606"/>
    <dbReference type="InParanoid" id="A0A6P8IZD2"/>
    <dbReference type="OrthoDB" id="425082at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572549.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30878" checksum="FD65E8C8F400AF6A" modified="2020-12-02" version="1">MPSVSKERRFKPRVLCWVDLTLENVDEILKSKSADETQSILADIFKIKDHKEELRSGILIDLYYYSIQFAKDNNFTKEQISAFFSIIKCIHEMAIDTPFGNVKPVFEYTKDLILCHSIKRPPFSIALFSTDQVKNITTYIVNTYFRHYKLYKYAFTPKVRLDLAIDYIGLPATPPPSEVGEEDEKMTEEKKEEEGEEAEVAAEPEIEETPAVKELKTMISTVLQEQVEQLKNSVDLQIKAKDEEISKKTGISLADSGTAPKSPKGKGKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZH0</accession>
    <name>A0A6P8IZH0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 181</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116306665</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts with HOOK1. Interacts with HOOK2. Interacts with HOOK3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCDC181 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572604.1">
        <property type="nucleotide sequence ID" value="XM_031716744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZH0"/>
    <dbReference type="FunCoup" id="A0A6P8IZH0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="116306665"/>
    <dbReference type="KEGG" id="aten:116306665"/>
    <dbReference type="InParanoid" id="A0A6P8IZH0"/>
    <dbReference type="OrthoDB" id="5988532at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026687">
        <property type="entry name" value="CCDC181"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14320">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14320:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="149"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031572604.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="48199" checksum="A18FF1D32827A5B7" modified="2020-12-02" version="1">MEESLLSEPRSGVEISITSPSRNTSEDEEEFIPRALLKSKEDIESSKDSNGEATINGESRVHVNGEASGEGILADELDRKLSLTEEGQESKGEDVEEHVNGEERKSNEEESEEKPANLEMIGDRVLIERDGKFELVDVGEIKAEYFEMLGLSPGEKKAETTDESNGVANGEEKRKNSPKRPEEKPPSKPRPKTTNIGDYRRRKDQRSSRSPERRSTSAKLSSRNDDYSHIKSVYGMTEEQLKIKRRREEAIAKRKKEEKQREEEEMRRKREDAERAFQAWLTAKLEEARERKRQEELNKTDDSLRERKTIEAQQAYEDWLASKRQQYKVTREYEERRQSEEARQFMIRDRQLCDEAFRRWLKKKRAEAKAKEKLKKRKRSKPKLKKKEPLPLNSKNITYLEYYGYRNHVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J124</accession>
    <name>A0A6P8J124_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D(2) dopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571828.1">
        <property type="nucleotide sequence ID" value="XM_031715968.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J124">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="GeneID" id="116305958"/>
    <dbReference type="KEGG" id="aten:116305958"/>
    <dbReference type="InParanoid" id="A0A6P8J124"/>
    <dbReference type="OrthoDB" id="5965524at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000368">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571828.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36352" checksum="30B8DDDB16D2EB9B" modified="2020-12-02" version="1">MISSEDIALRAAFSFVTVVGVTGNVLVCLVVLLNKPMRTSMNYLLVNLAVSDMMLLVFFSPTFIFKGTYTHPVGIIGDIFCSLITGETLAWIGGYVSSXFLLAVSVERYFAVAYPHSYGTSFITKNLKLLVAGCWLFSLAWNSVGFVWKRYNEKNGCVILWTEVQFKVYSMLSFLIVGLIPMVTMGILYSRVVYLLWFKNTIIRLDEEQQRKKKKRATKMVLIVSLVYALCWFPELTVFVLLAYSPGSVXFEVAYPATVALCCVNSAINPIIYSFHNNQFRHYLKKLVCGCCSNDFDNSFISTGDKSDARQGNVAQLQVQSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1Q3</accession>
    <name>A0A6P8J1Q3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Retinal homeobox protein Rx1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116306142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572048.1">
        <property type="nucleotide sequence ID" value="XM_031716188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1Q3"/>
    <dbReference type="GeneID" id="116306142"/>
    <dbReference type="KEGG" id="aten:116306142"/>
    <dbReference type="InParanoid" id="A0A6P8J1Q3"/>
    <dbReference type="OrthoDB" id="5987450at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF35">
        <property type="entry name" value="HGTX, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031572048.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20646" checksum="52B77BF5041002D4" modified="2020-12-02" version="1">MTGGSIADQNNRESSDASTFKKRTRITAYQRVQLESKFMSSAYISKSDQEQLSMELRLPCKTVQAWFKNRRYRWRKSGSPDKQGSSPGEQQMKLSSGQTSGLCYLPSVTTNTSSTNSANQTPSLYINSMVPNHSYNSHGFSNHSNHGYNSNGYTGLGYGSHDGPFSQMNTNYPAANFLTGHRPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J2M5</accession>
    <name>A0A6P8J2M5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116306022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116306022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571910.1">
        <property type="nucleotide sequence ID" value="XM_031716050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J2M5"/>
    <dbReference type="GeneID" id="116306022"/>
    <dbReference type="KEGG" id="aten:116306022"/>
    <dbReference type="InParanoid" id="A0A6P8J2M5"/>
    <dbReference type="OrthoDB" id="10318563at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571910.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19601" checksum="879A9BEC3A57E106" modified="2020-12-02" version="1">MYVVKNPDFKEAGVNFVLERWKAGSQIGIGTIDPKKWLSFRDDGDGDIDVYSASTSQFPIPNVSERYSIEIISKECVETPFDQLILAAPEKTSADDCEKLPDRCFLSLGWDYRMRQMQPGYCYYRKGSMCFKPSQRYKDVRYKNPKDCESNGLCWDYLAKYCYLGVDPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J335</accession>
    <name>A0A6P8J335_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosaminoglycan xylosylkinase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574376.1">
        <property type="nucleotide sequence ID" value="XM_031718516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J335"/>
    <dbReference type="FunCoup" id="A0A6P8J335">
        <property type="interactions" value="1936"/>
    </dbReference>
    <dbReference type="GeneID" id="116308140"/>
    <dbReference type="KEGG" id="aten:116308140"/>
    <dbReference type="InParanoid" id="A0A6P8J335"/>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10314">
        <property type="entry name" value="FAM20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF14">
        <property type="entry name" value="GLYCOSAMINOGLYCAN XYLOSYLKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="11">
        <location>
            <begin position="246"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031574376.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="53276" checksum="A8FD0B7C95F68CAD" modified="2020-12-02" version="1">MKLKERFIFGGCLGILIVPFLWLHITEYQERQLDENERTIRFLQAPDHSDFNSIEHGHSLSRTRLKFRSNQELNNIDSNNNVNMDTKEDKSLHISKEKRSTENLNEKDDGDDDDDDEPDDPWLTWKEMVKLRQLTSSQPGGVNTILDGLSFKPIVAAGIGYKGTQLKATFLLDGKQKVVFKPMRYPRDYVIEGKPYDGYDRHNGEIAAFHVDRILGFNRAPPVAGRKVNLEDEVEPIAERSLLNTFFKKDGNTCFYGVCHYCNKEEAACANKTVMEGSLTIWLPRGWGLAKWRHPWQRTYTSKKAIWEVDNNHCKRVLKKYPYDEGPRLLDIIDTAIFDFIIGNADRHHYETLKKGDEDGVLVHLDNAKSFGNPKVDEISILAPLYQCCRVRRSTWQRLTAIASDKSKTLGQRLKESTDADALAPILTSPHLKAVDRRLAIVIEIGKKCMDKNGKRKVLKDERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3D7</accession>
    <name>A0A6P8J3D7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307968</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574162.1">
        <property type="nucleotide sequence ID" value="XM_031718302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3D7"/>
    <dbReference type="GeneID" id="116307968"/>
    <dbReference type="KEGG" id="aten:116307968"/>
    <dbReference type="InParanoid" id="A0A6P8J3D7"/>
    <dbReference type="OrthoDB" id="5984844at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574162.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14320" checksum="6E49BD867F06C767" modified="2020-12-02" version="1">MLLELYLSSNLMIPDELHDISRLPELTFGDVEEYARKESGCSSTTKAYKFCAEPGYLHNIKVRYSQEKDKLNSRCYRSMKKSEPPHTLEADIDLASKSIKGRCSCVAGAGGFCHHVVGLIVGTRLRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3Z4</accession>
    <name>A0A6P8J3Z4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116306785</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116306785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572738.1">
        <property type="nucleotide sequence ID" value="XM_031716878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3Z4"/>
    <dbReference type="GeneID" id="116306785"/>
    <dbReference type="KEGG" id="aten:116306785"/>
    <dbReference type="InParanoid" id="A0A6P8J3Z4"/>
    <dbReference type="OrthoDB" id="5947360at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="90"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031572738.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="18941" checksum="821E576C4834E724" modified="2020-12-02" version="1">MSQSNLLLFDANGLKYDYDTTKPNLGSTTFTKYQVVNGKWILYRSIDFNEAIAGGSSSDIVTADKPTGELSLPFSVKSIRRLQDSCDSSTVFAHSYYGGHEKVYTSAVPDMCADFPNSGQGASSLIIWPNKSWNLYNQKYYEGGEKNAKSGWYPTPSAVGFPNDSLKSMRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4H9</accession>
    <name>A0A6P8J4H9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116308615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031574946.1">
        <property type="nucleotide sequence ID" value="XM_031719086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4H9"/>
    <dbReference type="FunCoup" id="A0A6P8J4H9">
        <property type="interactions" value="2852"/>
    </dbReference>
    <dbReference type="GeneID" id="116308615"/>
    <dbReference type="KEGG" id="aten:116308615"/>
    <dbReference type="InParanoid" id="A0A6P8J4H9"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF15">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="7">
        <location>
            <begin position="404"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031574946.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="77686" checksum="DAEFDF5E61046D79" modified="2020-12-02" version="1">MNLSSAEERKRKRVKQCSIEESFKRHRIQDNYDLGRAKSTSRFSPEMASEVPKSEDIDSEAALRRNVLAQAAEKRLLQSFSSVTSPVPVSEGSGSDVAVEAGGSRDALSESEGDVATIEFDSFPESPPLPEEYECCSNESESKIVSGGVPLCMLNRTPGCCAPMPPLMPQPDHTVLIRVSKNGDIAQPPKPSYSTYRDKWDKDHVRMPCSIENLYPIQNSSKKVQNRWELIESTLLSPIKSSYDLQDAILKYNARYSSRWNFEALHSYFNEVLDGNERNEFFNQTLPAMVRLTLQLPEVCTQAIPLMKQGKNHSITTSQHQAASLLANAFFCTFPRRNSHKHSEYSSFPDINFNRLFQGGKGGTSTVKSEKLKAVLHYFKSVTQSMPTGAITFQRQAIPIDAFPRWDKCTSTFTRLHVSTSGTIEDDGTGFLQVDFANKYIGGGVIGEGCVQEEIRFLICPEMILSRLICEKIDSNESVIITGAQRFSNYTGYAHTFKWAGNHNDQMPRDSWGRRHSQVVAIDAQVFHSYTDQFRTGFLKRELDKAFGGFFSTEDSKYLPAIATGNWGCGAFGGDSRLKAIIQMMSAAAAQRDIVYFTFGDSELAEDLLNIQSFIKEKGITIGDMWMILCKYGKEINAASSVKIKLYDYIYRLYQCYESDTDPESEEPIPLSTSSSDVSNNNPIEGSECNDPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6L7</accession>
    <name>A0A6P8J6L7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Extracellular calcium-sensing receptor-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Extracellular calcium-sensing receptor-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17" type="primary">LOC116309054</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031575444.1">
        <property type="nucleotide sequence ID" value="XM_031719584.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575445.1">
        <property type="nucleotide sequence ID" value="XM_031719585.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575446.1">
        <property type="nucleotide sequence ID" value="XM_031719586.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575447.1">
        <property type="nucleotide sequence ID" value="XM_031719587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116309054"/>
    <dbReference type="KEGG" id="aten:116309054"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="758"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="592"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031575444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031575445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031575446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031575447.1"/>
        </source>
    </evidence>
    <sequence length="883" mass="99494" checksum="2921735C7DEC744B" modified="2020-12-02" version="1">MKAAGLKATXLLHPYRAVRFVFLYLIIGIITTGSSNSMATTKNHSRLRVFKDGHVIIGGLIFLHEYRCDKFSPWNLGIVEAIMYAVNEINKDKEHLTNLTLGYDIQXTCGNEIITVKQAFKFATASNMNCKAVRCNSNNKCICNVNNTFVGSTYPVIAIVGMSPSRVAIALASFLQAVRIPYVESAATSEDLSSPMYDSFFRTVPSDANQAKAIADIVEHYGWRYVAEIAGDNSYGRHGAIALERESIQRKTFCVELLGYVPLLNYDNKLKMMISLLKLRKTVKVIIVWSGSSYAKEILRISVKEGLQNRVWIFSEALATKTPDYLSSIHNLSSAGFHILGVKVQSKVPESFRAHLKNRLVSNQSNQDHYLWNEFWKYVALTNLSRESSDQLLNITYDDYAIYMIDAIYSIAHALDRMLRFSSSINKELRPDIKETLKPGQLVEYLKQVEFEGVSGKVQFDSRGNLLEAIYDVVYFNVSKQNDKEMITKNVIGQWSKTKKVRISIVDAMQWKNENDERKIPXSTCADECKPGQWKELITNCCWKCLPCIDGSVSETNGALSCTPCTKTQMSNFEXTXCIPLPINNIDWSDIVSIILTIISILGFVIDVCVFGILFYFRDTPMVKALNKVCTLVLLXGIALCFGMTLLYIVRPSSGLCSVLKPLRYVVYTLCCSALFVKTMQIVHAFNISRHKNWVKAFVCSTKRQVIVLLAIISIEVLLGAGWIIWDPLYAHLTIFQKSHVLITCVPFRGTTCEVLDSLMLLYLLLVAGCCVFYAFRARNLPANFNEAKHISFSLYIFLLSWITYYPVDYAAEGWYVAVLSGTTLLLSSYGLLGCIFGPKLFIIVLHPEKNTLEFIRAEMRQNNMNQSLGNNSSSCNVKLTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JD03</accession>
    <name>A0A6P8JD03_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26 27" type="primary">LOC116309069</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26 27" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25 26 27">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031575467.1">
        <property type="nucleotide sequence ID" value="XM_031719607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575468.1">
        <property type="nucleotide sequence ID" value="XM_031719608.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575469.1">
        <property type="nucleotide sequence ID" value="XM_031719609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JD03"/>
    <dbReference type="GeneID" id="116309069"/>
    <dbReference type="KEGG" id="aten:116309069"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004509">
        <property type="term" value="F:steroid 21-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="10 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 22" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031575467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_031575468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_031575469.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56198" checksum="759FAAC8FE227F26" modified="2020-12-02" version="1">MFVEVPVVVALLVLTTLYFLITRKQDQNSPPGPFSYPLLGNFPQLGPVLHLSLTDLGKDFNGLYRLHLMGKKINVINRGKTAKDVLVNEGKNVGDRTSAYVIDLMTRNGCSLIFGKLGPTWKSQRKMVHSALRFYSGGSADVENLIIKEANELNEILRSTKGTAIDPKLPLTLCVMNVICSLVYGKRYELDDKEFHQIVTNTEALAKLASPENPLILLPWLRHFPIKTVKRMNEIIKERDRIVKEKIDDHRRSYRSGVTRDLTDTILKCMEDENNNGLLTDDHLHMAVSDVFLAGFETTTTALRWILLYLILYPEVQAKIHQELDEVVGSDQAPWLEHKERLPYLQATINEVMRISPVFPIIRRKAIGDFKIDGYDINKGSFVYVNLWAIHHDPEEWDSPYEFRPERFLKDPEKSQNMFPFGAGTRVCIGKSLAKSELFLIVSRLLHEFELTLPPGSMRPDPTGLTSTVYWPKPFQVCAVKRFQNFNNVELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GWS5</accession>
    <name>A0A6P8GWS5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116286363 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116286363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031548704.1">
        <property type="nucleotide sequence ID" value="XM_031692844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GWS5"/>
    <dbReference type="GeneID" id="116286363"/>
    <dbReference type="KEGG" id="aten:116286363"/>
    <dbReference type="InParanoid" id="A0A6P8GWS5"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047940">
        <property type="term" value="F:glucuronokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000090">
        <property type="entry name" value="glucuronokinase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053034">
        <property type="entry name" value="Glucuronokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710:SF1">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="1">
        <location>
            <begin position="388"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031548704.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55329" checksum="75B6B46DD6EEBB2B" modified="2020-12-02" version="1">MICVILVAGHGTLLEKQIKDDLSGKYIGLQGVPKALLPGVGGKSILDFWWEAIKMRQLFTDVFLVTNADKYKYYERWATAHDFPVENIVNDGTTTFETRLLENKKHRIKNSRIIQSAQGLGAVADFELVVRTKNIQDDVVVVAGDMLFQDGNFDMAQVIKYFKLKKGELAIYYEMHGMEQTETRGIVEVCPLTNRIERFLEKPKPDQTTSRLASVVFYCFQKETLSTLEIYLKKRADIDQRGFGNYLEWLVNQTPVYGMKLPTGFQLIGQVGLSEYEKWVAYFSSISQKGCPLEPYVARAYARIGLMGNPSDGFNGKTISMSIANFWAEVTIQESQQLVLVPHPLNDPTEFGSLGDLHGISRKEGYLGGLRLLQATCKKFYQYCYEKGIALAKKNFSLKYDTNIPRQVGLAGSSAIVTATLRCLMHFYNLTDKDIPKPLQPKFVLDVEMDELFIQAGLQDRVIQVNFKLLWYQGSTPIYSVRLRISAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H226</accession>
    <name>A0A6P8H226_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116287878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550444.1">
        <property type="nucleotide sequence ID" value="XM_031694584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H226"/>
    <dbReference type="FunCoup" id="A0A6P8H226">
        <property type="interactions" value="2323"/>
    </dbReference>
    <dbReference type="GeneID" id="116287878"/>
    <dbReference type="KEGG" id="aten:116287878"/>
    <dbReference type="InParanoid" id="A0A6P8H226"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031550444.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17727" checksum="66B680F8053E613A" modified="2020-12-02" version="1">MEEVQGEAELLTLYFGVVARKYKRFVSLIGPNYDIMEGIVQLMDSNCTVSSVAKYCSNCGDLFLDKMTERKAVIKNADMSEDMQQDAIECATQAIEKFNIEKDIAAFVKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H261</accession>
    <name>A0A6P8H261_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer. Dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031549728.1">
        <property type="nucleotide sequence ID" value="XM_031693868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H261"/>
    <dbReference type="FunCoup" id="A0A6P8H261">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="GeneID" id="116287221"/>
    <dbReference type="KEGG" id="aten:116287221"/>
    <dbReference type="InParanoid" id="A0A6P8H261"/>
    <dbReference type="OrthoDB" id="447477at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:L-tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019442">
        <property type="term" value="P:L-tryptophan catabolic process to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138:SF0">
        <property type="entry name" value="TRYPTOPHAN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549728.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46784" checksum="CDB138A2B5BB802E" modified="2020-12-02" version="1">MSCPFASSSDSGIDQGNNYDERLNYTDYLQLDKLLDCQKLMSEEKGSHRASDELLFIVTHQAYELWFKEIIFEIDSIRELFLTEAGVLNEEKTLMVISLLKRIVAILKLLGEQFQCLETMTPFGFMEFRDYISPASGFQSAQFRVIENKLGVLRASMRKDSQECCKALRTGKDQTDYVKSEESPSLLEVVEKWLSRTPGLEEDGFNFWGKFKASVYRWLDSLKMQALAQKNEFLKADMLKNFKSTTDTFESIFNEERHNQLVTRGERRFCYKAFQGAMMIYFYRDQPRFHQPFQILQLLIDIDSLIIKWRYNHLMLVQRTIGTKAGTGGSSGYQYLRSTISDRYKVFIDLFHLSNFLVPREYIPHLTRDMKTVLRQVHNHGESDSAHYSDSENEELGLTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H2S7</accession>
    <name>A0A6P8H2S7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549736.1">
        <property type="nucleotide sequence ID" value="XM_031693876.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116287230"/>
    <dbReference type="InParanoid" id="A0A6P8H2S7"/>
    <dbReference type="OrthoDB" id="10067267at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027784670" evidence="1">
        <location>
            <begin position="29"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="144"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="299"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="451"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="4">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031549736.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="63537" checksum="02EE9AFF49695737" modified="2020-12-02" version="1">MQGFSSNQGVFLKCLTVFISIILHQSTACSERPVGIANSTIIPDDRFTASSYYDTNGDTRYEPKDARLNGADRGWGPKMETDPNDYLQIDLGHLFPGNTDSNTVVKNVLDYSVLVRHIRFIPTTYNKWKVLRVEAYGVRRGLLCSSLPVGIGSGNIPDIGMTSSSAYNSTTSPSKARLNYIAGSSWCAARNDSSPYLQINLGSTYIICGIATQGDHMTDQWVQSYHMLTSNDGSTFTKYMDNSQVKSFTGNLDSNTAVKNLLLDGXVTQYIRVAPTSHFGSTNCLRTELYGIMKHIGACASMVFGLSYSSIIPDHRFTASSYYDNRYKPHFARLSTSSKAWGPLTTSGGDWLQVDLGSVVFVCAVATQGAGDLNNEWTISYKIXVSLDNVNWNYYQENNINKTFTGNTNRDQVVIDSLSHPIKAKFIRIYPLTFHSWPSLRVEVYGVSSTCSTPVGLQAPGVIQDXQMTSLSNLDNNHTASHGRLYGXSSWCSGNSNNTQYIQINLGXAMTVTGIATQGDHTMDRWVTNYTISYSMVDNLWHTFKSANXSDKVDTNIKYYRREKLXHILEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4G3</accession>
    <name>A0A6P8H4G3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550321.1">
        <property type="nucleotide sequence ID" value="XM_031694461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4G3"/>
    <dbReference type="GeneID" id="116287741"/>
    <dbReference type="KEGG" id="aten:116287741"/>
    <dbReference type="InParanoid" id="A0A6P8H4G3"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF163">
        <property type="entry name" value="CALICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550321.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="62914" checksum="8E1F60A403A5272A" modified="2020-12-02" version="1">MSTIQYISSSNAQRTLLGLHAMYELQELCDVILETEDGFSVSVHRNVLAALSPYFRAMFTGRLAESSKEKIKLRDIEGESLQGIIKFMYTSSVSINDDSVESLLKAARVFQLIEIVNVCCEFLKEQLHPSNCLGIAALADRFSCEELLDEANKFTVKNFNEVVKFDEFKQLRLEEVKTLLLDENISVRSEEDVYQAAIDWLSLTSEPRSMYTAEVLGCVRLPILSPEYLTTNVINNKLLEGNDECQLMVKEAVEYALSPSSEKRKHGYVTRMQPRMPTGFADVLVAIGGLFSGEAVSSTERYNLYTDEWFTFPAMRTSRYGFAVTQVRGRIYCLGGYHNGQFLNTVEAYNPEDDSWALQKPMFTKRKYFGAACLCGKIYAVGGSNGQERLKTVECYDPFSDQWTFVAPMLTPRMYHGVVALGGLLYAVGGHSGANRLSSMECYDPQTDVWTPVSSMDKPRSVAGVAALNGVLYVIGGFDGYNYLKDVECYNPQTDTWTVLPSLNRPRSAASVTVMKDRLFVLGGFNGQFLDSMEIFDPRINEWNFASSMSIPRVHFGVTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H512</accession>
    <name>A0A6P8H512_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116287967</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031550541.1">
        <property type="nucleotide sequence ID" value="XM_031694681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287967"/>
    <dbReference type="KEGG" id="aten:116287967"/>
    <dbReference type="InParanoid" id="A0A6P8H512"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000088">
        <property type="entry name" value="Receptor protein-tyrosine phosphatase LAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001223">
        <property type="entry name" value="Sidekick cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF553">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 10D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028079947" description="protein-tyrosine-phosphatase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="426"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="521"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="872"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="1333"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1587"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1431"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1450"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1499"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1587"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1620"/>
            <end position="1630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031550541.1"/>
        </source>
    </evidence>
    <sequence length="1630" mass="180651" checksum="7E4D6427B407B9BB" modified="2020-12-02" version="1">MKTIAVLLKMKEITVCLLLILSIVVSQSSNSNVSNTINAQFTSSVIGQVGVTTTAAAAEDKRKSISSSVEYSTSTMTVTSSSPMDLVSTSSSLSDFSVKTSTSTPGLDTTVLRMTSTADPSAPTTLTQAMTSAAANKTITSAMSSVEATKATQVVTSSSVNESNKTDKSTTTPLSVTSESESVTPVMSRTATKTTQYVTSTPESKRVTPVVSYTATKTTHYVTSTPESKRVTPVVSPTATKTTHYVTSTPESKRVTPVMSHIVTSATKSTAQSETFVPASESVTVVVSNETSKTTESVTSKAITFSVASSFISTFVTTFQRATEIPSRFTVSINANVTDVPSVTVTTSTTAIPVTSTLAPNKSVTTSYSVSEAISRPSVTKTTDITSSVAIVTSVTHSSTVATSTQPPTTIPSTTTKPTTKPQVAPEFKTPPPNNKTVKEGETLVLTCTATGTPTPVITWKKEKIKLQNTSSIVISWDKSKIKILRTTREDEGTYQCNASNGVGRGVEAGTKVKISYFSGLQVKITEPDAHQSIREGVDVILTCSVDAYPRPFFTWKKDDKEDGVELGSRQDSNGSRRFSDLYLPNISRKNGGNYTCLAYTGTDLLGNANKMLNVELSLVPTYPPSNAMKTTDHTITIHIHKIEYLGNGKRVSYIQVIVKQLKNQTLPTRQPSHLEPSELGPYSKNRTELYIAAVILLKDIGRGPTRLVLGDESMSYTPTKARSRRNPREEHEQYYNAPLLPETYYTAFQRMMSKDKYHESLGWITATKTTTQSQVVDDSDLSTILWIVCVSLIVLIILIVVMSVYIINKKKTHEIDIDDGNSGKNAFGKMARSLSIHMARLHEHYHPSGPIPVENFAHHVARMHKSGDMHFSTEYERIPEYDSIPATHSIDPANQWKNRYSNIVAYDYNRVKLIPYDDEPASDYINASYITGYNNENTYIAAQGPLDETCGDFWRMIWEQNTRVIVMLTNVRERGRLKCSQYWPTSGKSRYEVIYVSLEDVVELTSYTIRVFRVAMTGQKETRMIKQFHFTGWPDHGVPKSATFLLAFVRQTAKMNPPDAGPMVVHCSAGVGRTGTFIVIDTMLQQIAQEKTVDILNCVTQLRKQRNLMVQTEQQYIFIHDALLDVIISGDTEIHASNLRKHVQEMIEPFKETGETKMALEFQRLSRGVRPHYTITAATTPANKSKNRYANTLPYDDTRVPLVVQTAVNGSDYVNANYIDAYMKKRAFIATQAPLPETFDDFWRMIWEQKCYTIVVLAQEMENDKLKMNRYWPTTHPITFGVLQVAMLEEEKKEYLETRVFNITNTMDNSCQIVHQFHYTAWTSEDLTDSGINILSMIEQIQQWQNASGNHVITVHCSAGVGRTGVFCAVSSLIERLKAEAVVDVFQTVKQLREQRPAMVQTKSQYEFCYRILLEYLDTHTSLEELDSSPALSQSYNTGNPPESEKTQNEISEQSSLESAKSNGKSNLVDSGIASDSLSEVKQKNSPNHIVPSTDTSENFKQRDVTPEDKAQVNVTPKKEGLENVCLEVTLENGVSQQNATRENITQKDISTENNRQKSVTLEDDVTLENTAHEGVTEHEFIQDITPETHQKADDEPLANSQAVLRRADSEESDPYVSPLSSSLNLNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6F6</accession>
    <name>A0A6P8H6F6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Tyramine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC116289230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551979.1">
        <property type="nucleotide sequence ID" value="XM_031696119.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031551980.1">
        <property type="nucleotide sequence ID" value="XM_031696120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6F6"/>
    <dbReference type="GeneID" id="116289230"/>
    <dbReference type="KEGG" id="aten:116289230"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000523">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="51"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031551979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031551980.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39460" checksum="0DA0C80BB6C50EE0" modified="2020-12-02" version="1">MIDLKSTNNLTNGSQGIVNSTSEPDIPKFSTSTVVLSSLFVVILIILTIFGNVLVIMAFKTFRRMRQVTNYFVASLAVTDILVAVIAMPIWVAYLITGPLWVFDTVLQMLWTSTDIMSGIASIWHLTFVSIDRYLCIASSLKYRSIMTNVRAVFIILGIWLYSIVIASVAPTLWAWRGYSLVVTLLNFIIPVIVISIAYFRIFQLARYHAHQIELSLGGKHGRFFKKELKATKTLAVVIGAFLICWSPFFGLNLSYYICGCPPSPVIVAIAKWAHYGNSCLNPLIYGVMNKEFRRAFKKLLAPYLPVNAPNILTTNGGLNSASRQSVDTGQHQAIYQLRNSGEMEEQHRSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7I0</accession>
    <name>A0A6P8H7I0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288739</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551426.1">
        <property type="nucleotide sequence ID" value="XM_031695566.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288739"/>
    <dbReference type="KEGG" id="aten:116288739"/>
    <dbReference type="InParanoid" id="A0A6P8H7I0"/>
    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551426.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="28182" checksum="C037D02CAAD86252" modified="2020-12-02" version="1">MKLICAGLLKTGTKSIARALRILGYKVYDFDEQILYYMDEWLDLYKHGKKPDXYTMFKDVDVVIDGPCNFFFEELIEAFPDAKVILSIREEDAWIRSYTKHDETAKNSFLVKIKCLLPTLKNVWFIFINGRIASVGSPGPKSSYICRKRYRWHNDRVKSVVPADKLLVYSVEQGWKPLCEFTGKNIPDQLFPHLNVKGEYFGIFLKETQLGKKIVGEFRVLQVCCVAVVVALIGITLIYLFTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H898</accession>
    <name>A0A6P8H898_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116286548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548967.1">
        <property type="nucleotide sequence ID" value="XM_031693107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H898"/>
    <dbReference type="GeneID" id="116286548"/>
    <dbReference type="KEGG" id="aten:116286548"/>
    <dbReference type="InParanoid" id="A0A6P8H898"/>
    <dbReference type="OrthoDB" id="5987170at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031548967.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24845" checksum="8ADA54F211C83A35" modified="2020-12-02" version="1">MEDLLVVLYSWFSCNNGCPSNLICQVSLVAPNWWLSRIATMPQQQQKNRVVLGVFSSLIAAAIIFSVTRAFANVVSIIRSLQRIHNKMFKAIFRSPVLFMDRNPVGRIMSRFCKDTGCVDESLPEKFAWTVMLCLYFAGVMILSVLVNFWMVVAIVPVLVIFLFIYWFNLKTSRELKRLEAVRCSPMYAHIADTINGLVVIRSSEKQKDFMKQFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8P0</accession>
    <name>A0A6P8H8P0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116288883</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116288883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551608.1">
        <property type="nucleotide sequence ID" value="XM_031695748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288883"/>
    <dbReference type="KEGG" id="aten:116288883"/>
    <dbReference type="InParanoid" id="A0A6P8H8P0"/>
    <dbReference type="OrthoDB" id="5985786at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551608.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27095" checksum="A8B1E4E90AE4B517" modified="2020-12-02" version="1">MFLKCNTNNLAETVLHLFEETIEENGRLWPSRIRVDHGVENVLVCDAMVARRGEGRGSFIAGSSTRNQRIERLWRDVFRCVCQFFYYHFYAMEQTGILNVDNPIHMFALHLVFKPRINCSLNVFKNMFNNHGLSTESSWTPNQIWLNGMLNESNPLSQNGLDDVDADTFYGEDPEGPSPFSSSDNNVIVQPVEISHEEELSEYVLQQVNPNMNSTQAGIDLYERVLSLVLEKLQXF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HA69</accession>
    <name>A0A6P8HA69_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116286936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116286936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549390.1">
        <property type="nucleotide sequence ID" value="XM_031693530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286936"/>
    <dbReference type="KEGG" id="aten:116286936"/>
    <dbReference type="InParanoid" id="A0A6P8HA69"/>
    <dbReference type="OrthoDB" id="5985287at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF19">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031549390.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55429" checksum="0905ED582CB331C2" modified="2020-12-02" version="1">MASGFRLPPPPPLDIHDAKAAEKWKKFLLAWKNYSVATELNGKPQAVQVATLITVIGEEARDVYSTFSDSENEDEDEETEIERVLRKFGEYCQPRKNVPFEXYRFNTRIXEAGESYDQYKTALRKLAEGCDFDTITPDEILRDRLIFGIKDAKVRERLLRETWLTLSKTDEICRASESMIQQMKVVQDSNNTGSEVNKFYNERVTTHRKPRNASRRKSSNERQSTEQSKECDNCGYRHAANRESCSAFGKECRRCGKKNHFAPKCRQEMNHFASKCRQEINVTEEEEDPESEMYQTDEILAVKLDDSQLVTLKLETGCFXRFQPDTGAQCNVIPLHIYKKATKDCESVQXKPVQTSLVAYGGAKIAVVGEVCLRVWRNETSCLLDCKVVDNKDIRPILGRRXCIRMNIIQYTDXDLLNKPDVNGAPIYSVETQSTPISKEELFAKFPNVFSEGVGKLDGEYRIRLDPTVQPVQQAPRRVHFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HB38</accession>
    <name>A0A6P8HB38_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC116289519</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="RefSeq" id="XP_031552325.1">
        <property type="nucleotide sequence ID" value="XM_031696465.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552333.1">
        <property type="nucleotide sequence ID" value="XM_031696473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HB38"/>
    <dbReference type="GeneID" id="116289519"/>
    <dbReference type="KEGG" id="aten:116289519"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04021">
        <property type="entry name" value="C2_E3_ubiquitin_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000157">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="497"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="149"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031552325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031552333.1"/>
        </source>
    </evidence>
    <sequence length="831" mass="95465" checksum="E521DB68830793CE" modified="2020-12-02" version="1">MVDTPSTGQSSQFSQLKVTVSRAKLKEQNGWFSKGEPYVKLIVDSKAPPKKTEAVKKTWEPVWNESFTILVMPYSILEFEINNRFALKSDVPLGSTKIDLNDTLHKNNGKLNACSIKLPIMFNKNGTKVQTGDLDVILDGLTINMRQFPRRRGKVSSNGSAVDGAGSSRAAVNNGDVCRRDNRSSHDQRQRPVSTSALSGPSSVGQPSSGSNARSSLSLATTAGAADTTTTPSNSNMTLGPPSSRPPPPQRAPTGPEEPLPPGWEQRVDPHGRIYYVDHNTRTTAWERPQPLPHGWERRTDSRGRTYYVDHNTRTTTWQRPTVESIRNYEHWQTQNRAMLNTERQHFQQRFLLPMGPTAAPQETDQLGPLPPGWEKRVESNGRVYFVNHNTRTTHWEDPRAQAAVKDEPLPQGWEMRYTNEGIPYFVDHTTRTTSFTDPRMPPPAIVGGPTYERSFRWKVGQFRHLCQANALPSHVKITVNRNNLFEDSFSQVMRYQPHDLRRRLYIIFKGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYANKNNYSLQINAASSVNPDHLMYFRFIGRLIAMALYHGKFIDRGFTLPFYKRMLNKKLSMKDLESIDPEFYNSLVWIKENNIEECGLEMFFAVDMELLGKVTSHDLKPGGSEIEVTEDNKDEYILLMTEWRLNRGIEEQTKAFLEGLNEVVPLYWIQYFDEKEMELMLCGMQEIDIEDWQQNTVYRHYTRNSKQIMWFWQAVKAFDNEKRTRLLQFVTGTCRLPVGGFAELMGSNGPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLVEKLTFAVEETEGFAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCB3</accession>
    <name>A0A6P8HCB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein LOC116287770 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC116287770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031550317.1">
        <property type="nucleotide sequence ID" value="XM_031694457.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031550318.1">
        <property type="nucleotide sequence ID" value="XM_031694458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HCB3"/>
    <dbReference type="GeneID" id="116287770"/>
    <dbReference type="KEGG" id="aten:116287770"/>
    <dbReference type="OrthoDB" id="5781878at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653039" evidence="3">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="4">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031550317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031550318.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22072" checksum="9468896EECB49943" modified="2020-12-02" version="1">MNQVISLCTVLVICQSWTGRAAIVPGIMDLLNIDVTTLPTVVNTWPPTKPGQVNSPPCTKTKYGCCRDWHTPSPGPNEEGCAKKLCYDDFPGDCLIKKMTKTLDCTPGGYDFKHCTYRCGVCKLPASPISRCQRLNPASGCCWDGTIPLDRYGSGCQPCEDLFPHTCQQFVHVSGGCDSGSLGIRNFMMTKCPKTCGLCVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HDZ9</accession>
    <name>A0A6P8HDZ9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glycosylated lysosomal membrane protein B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116291609</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
            <orientation evidence="9">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554649.1">
        <property type="nucleotide sequence ID" value="XM_031698789.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HDZ9">
        <property type="interactions" value="969"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116291609"/>
    <dbReference type="InParanoid" id="A0A6P8HDZ9"/>
    <dbReference type="OrthoDB" id="6264340at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981:SF1">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15065">
        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028146163" evidence="12">
        <location>
            <begin position="30"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="14">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031554649.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47750" checksum="8DF192F05E04178F" modified="2020-12-02" version="1">MVALSQLSSRLSFLLLFPIFLILIEPCYSXERKITKTEYTCSSSNFKDQNISIFYVKAEDTRQKNTVQFIWSVFETPSIIVAYTSKKEYGKXSGLNIDCSKLLQGSEGAIQFQLKYDYIVAFEISELHEFNDPDDNVIFSKSDFDGYVHKMNNTYWKNPQEEKDNVIFVGDFLNGSISFQCLAATNDGRDEVAPKQLYSSNSTRFTISLKNLKLNTTHTRXALKLLTHTRKEEDKTCVMEDQSIDDEYSPGVFRTFVINNTVLNADGLSSSISWKPVSYNDEPRKLLYQVPSYQYLYDSNNEYPHSKVDGSCKKSLISSLEDRPSKVIRAAMNVGKTYPMMVSFGQNKDGWYEKSEDLIWSGQVGYGKPQFDKISSTVFIAIIVGLGLPFAFIFAGSIYICVKKYRKRMTTSTYEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HEI6</accession>
    <name>A0A6P8HEI6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116288397</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031551042.1">
        <property type="nucleotide sequence ID" value="XM_031695182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HEI6"/>
    <dbReference type="FunCoup" id="A0A6P8HEI6">
        <property type="interactions" value="1044"/>
    </dbReference>
    <dbReference type="GeneID" id="116288397"/>
    <dbReference type="KEGG" id="aten:116288397"/>
    <dbReference type="InParanoid" id="A0A6P8HEI6"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="65"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031551042.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29858" checksum="B0B0D629AE23D146" modified="2020-12-02" version="1">MCLTTSWPFCRVAMEKISWKIESSVIVAAVGGASNLWLKWLNTVRVHNQITLDQCTADRPDGVPLVTVSNHYSCLDDPLMWGILKLKVLFSREKQRWTLGAKELLFSKPLHAFLFSRGKVIPVVRGEGVYQKGVDFALEQLNQGQWVHVFPEGKVIEDGSLVRLKWGVGRLIAESKVTPIVLPLWHVGMDDILPNQKPYIPQIMKKVTVLVGEPIKFEDILKDYQKRKKSATEARKHITDVIQCRFKELKEEAEFIHSKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HG08</accession>
    <name>A0A6P8HG08_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116290922 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116290922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553903.1">
        <property type="nucleotide sequence ID" value="XM_031698043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290922"/>
    <dbReference type="KEGG" id="aten:116290922"/>
    <dbReference type="InParanoid" id="A0A6P8HG08"/>
    <dbReference type="OrthoDB" id="5978906at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031553903.1"/>
        </source>
    </evidence>
    <sequence length="664" mass="74807" checksum="4E14FAEE48CA94BD" modified="2020-12-02" version="1">MASRCIKALNDLDDISDKVFYKYSKNRFRSEIQGRIKASKSKVDRSLDQNSPPKSEKRRGSTGSFSLXSKESPGPNTSAKARGTKSAANPKISHTQIKEQKERAKSTSYCRNRAHKTLLKKNEQKNEEMKEKSSLKAVGKTPSVYGKHYQDEERTCTESWFNFDDGVKMGSIDSFVCDDRNRKALCYGLDKKEAKXVPKLLRHRLEVRIGQNGEVRDDNGGIKKTDSKDTGDNNMCKKMPLSWEEQLNWENACIKSTRSPSQQKTEDQGLCETHPVIFHPQESPTTLSSSPSDIGDTTAAYRMFLERRLLVSDRGNLMYGGKCITSVEIEDARDEIKEKKELKMINTSLKAYVVDDDRMDMGATIRNIQNIYPRRSAASKSSLMFNPENVVANTEPSEFNQVENIDEVSDRDNTQSIDSERMDKINKRVSFKDQTDLTEKYDGLGVQDTNAEAVRDANMPISPSKVRPKSSKERSRVLTDVNEKPKRPYTAPPCSPRLTQDEDFEKEIARPFNLAPVCVXTSQVNLSDQDENNEIPLPDNGENLTTDNDNELKDISIKDTNESKPAMRVSVACKSAPMXGRTQTPEEPISRSLSSMSTRTNKNKYVPTQPVAVLADSSLELPPNLPPAKALVELRKKIREDLAKETADLQLDIQQLYLKHHASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGR1</accession>
    <name>A0A6P8HGR1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amyloid protein-binding protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555036.1">
        <property type="nucleotide sequence ID" value="XM_031699176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGR1"/>
    <dbReference type="FunCoup" id="A0A6P8HGR1">
        <property type="interactions" value="2756"/>
    </dbReference>
    <dbReference type="GeneID" id="116291942"/>
    <dbReference type="KEGG" id="aten:116291942"/>
    <dbReference type="InParanoid" id="A0A6P8HGR1"/>
    <dbReference type="OrthoDB" id="7103806at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042476">
        <property type="entry name" value="APPBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575:SF1">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555036.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="66746" checksum="6A1C298F5DDC7FD7" modified="2020-12-02" version="1">MADGTEESVLTLYNLAVFKAVRHQNVFRTEFRYLPDAIQCDIYRQLFHAGEYDSLADELLDLEAFAKALRAGDRRVKLYYPFQELIDKGYNLPKEISQEFCQRIKISLHEKENVAKHYGTLLSIGWLIGGFLTETGWHLAAEDIFEACLSLCDIRKTDDCAIALRCFTRLVYVRTAYCKFTEAKHSFDDAMELVQKLRNRGQKVNTAVLYGEKCALLFALSEYEQAYQNSIRALEEITQGLPEKAVIDIVRQASKACVVKRKFKKAETLIKQAMELARLYFGEEHPKFADTLVDYGFYLLNVDSIHMSVQVYKTALQIRQKVFGKNNVHVATAHEDLAYALYVHEYSTGKFDEAKYQAECSISIVTGLFPQDHLLLASSKRVKALILEEIAIDCYDKEKESKILQEAQDLHLSSLDLARKAFGESNVQTAKHYGNLGRLYQSMRRYKEAEEMHKRAIEIKERILGSEDYEVALSLGHLASLYNYDMERYDKAEELYIRSIAIGRKLFGDGYSGLEYDYRGLINLYDSLGDFEDSDKYKAILIEWKAIRERVSQNNVMDVDTLGDPRPTHQFIESFLSELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIW2</accession>
    <name>A0A6P8HIW2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat shock 70 kDa protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC116289727</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552529.1">
        <property type="nucleotide sequence ID" value="XM_031696669.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552530.1">
        <property type="nucleotide sequence ID" value="XM_031696670.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289727"/>
    <dbReference type="KEGG" id="aten:116289727"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10238">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042049">
        <property type="entry name" value="HSPA14_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031552529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031552530.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="56416" checksum="989A81AD4E141963" modified="2020-12-02" version="1">MADKVVXGVHVGSTSTCIAVCKDGKTEILTSDSGERVTPAVVAFSGKEKNVGLHAKQGLIRNSKNTIVRAKKVIGLRFSDEIVQEEIKSSDCKIIEKDDYPYYTTESEGKSITVSPKEVLTEIXGKMLETVTSYSGAGDKSVVLAVPHDFSEDQRKTLGEAAEAAGFHVLRLITEPCAAILAYGISQNERSVDSTVLVYRLGGTSTDVSIVSITNGMYRILAHQRDHTLGGRNFDELIANHLALEFKRQWKIDPLTNKRSTAKLYSAAENIKNVLSNLDSAPVTIDTLCEGFDFQTKLSRARFESLCSQLFQQCLVTIEQVLTKALLTKNDIDKVILVGGTTRIPKIQRILKEYFVGKEICRRIDPDEVIAYGAAVEASILQGRKEQTDSLLDEVQCMAKTISVSVGADTPRLIPVIPKFSPFPLRKTHTFTTSQDNQESVCLSVYEVDDSLKGEEVSSKVLLGKIILKELSSVSKGELKFSVTFHVRKDGSMHVHLVERQSNKASDITIETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJ83</accession>
    <name>A0A6P8HJ83_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase rnf213-alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554913.1">
        <property type="nucleotide sequence ID" value="XM_031699053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291840"/>
    <dbReference type="KEGG" id="aten:116291840"/>
    <dbReference type="InParanoid" id="A0A6P8HJ83"/>
    <dbReference type="OrthoDB" id="5976613at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554913.1"/>
        </source>
    </evidence>
    <sequence length="1572" mass="176682" checksum="0EB6F56D0657D7ED" modified="2020-12-02" version="1">ADGGTGNQDQAEEQDGNTSSVALGDASDGSASADGGIGNQDQAEEQDGNTSSVALGDASDGSGSADGGTGNQDQGEEQDGSTSSVALGDASDGSGSADGKDAKQSEDAKEGNNSKEGKDAKEGNDSKEGKDAKEGNNSKEGKDANEGKDANEGKEGKDAKEGKEGKDAKDSKDAKDSKDAKETKQDKESKDAKDSKGAKQGKDAKEGKDVKETKQDKESKDAKDSRGAKEGKNAKETKQDKESKDAKDSKGAKESKDAKETKQDKESKDAKASKGAKQGKDAKETKQDKESKDAKDSKGAKEGKDAKDVKDAKDVKESKDVKQHKESFQASTGDGRSSSDDNYMTIVLHALLAPHFQFDPDEDIVVVRGGFPNFSGWKKDHLQMTPIRPLPDGYIVIEGTTTILLKNAREKINYKYLVLKKNDNNEMWEELIDCHSNNKAHVNRCFSIPEQYRKPKGVWHQYDDAVFSQPKFWESVRNKLPYWKGMDPYEGRELAIEAVLPDWESFGLDETLGKRKGKEVLGTINQVIHCMEYLEAELYGRTMLRILNGFSLDQVILSYVEPRLKKNYELAQSTNDENVQANRLATSLTIVAVASTFIRKLSFHPTQGHLVAMFECLALNSTLGRQRIERIMEILAQHYPRKNWMRFSGAISELCQYAINHYPDVHQWLLAVPLMHFMSDESQPYTDAAPLSEPTLRDASYWGTNGLDVTQIQTLPWRSPIGFLSRLKPMFEVDPLLRRTFLFALPLSNLGRCVVQGAFLPYEVNWTLAYRLQNIKYYNQEELTSINTCLDVMMNSGYLDSENKDESVYGSLDELTSLAKGSLPVLECLLIPLKDVFQLACKVLHLLSKCLWAIKSSGSTSDQAESNNAFCARILKEATEKVQNRLSKSFSSNLIRAADYYRNEELKIWSAFLSVEFLDEVLQTSWQTKLMESLKARADKMDDMQKIDFYSTVNLNHLHKEVEKCFQEAAFDAITRIIEAGREAEHAKAFASLTQHDPNSIQSRRVGDMMSLLLNRCWPKDTEQQGSLLTHVLTWSPMANYLRYFSENSLTLPDESQLLLTRTTSCLEDIHRMVSDASVTVNTLRILRGKEDKYCELLEIMRYSIGDSDEDSDEDSDEESEEDDEQDDTNKDFGRIYKKARATLQTRLDELAAFEQEREQLRSFLGISSILEHVDVDDMKERVNADVSKDDISDLAVHTCGKRYGEAQVQVTFFGLSKELKTMITTMHTIHNSRIFNNIWREKIVDSQPDEQLTLEEVVKQVWTPTFKKCKDILQAVLTGNITLGDVDKRFEGFKDRYAELEQELVIMDACSATVDAGRIKKQVNQIRQYHRLTNYIAAADKILEFAEKMNLRGDFDMVDTFRLQISPESKRQPLKSLQEEFNQTGGILGEFTPERLQCLDAVMESKDFIVWLKKAVPDPSEIKVLVDLAMMSAGEGDMESDRIAALHTCTRGFKPLIYDLEEDDGFERLVELCSDVWDDLEHNPRLPLQMNDTSRRLEWLKNVLEFHGSVTMSSLQQVETIMKHGTLTIGCHXKGEEININTVISLRVPPENVKGMQKETYSLEDLKDLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJB8</accession>
    <name>A0A6P8HJB8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor SF3b 155 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Spliceosome-associated protein 155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116293217</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556479.1">
        <property type="nucleotide sequence ID" value="XM_031700619.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HJB8">
        <property type="interactions" value="3046"/>
    </dbReference>
    <dbReference type="GeneID" id="116293217"/>
    <dbReference type="KEGG" id="aten:116293217"/>
    <dbReference type="InParanoid" id="A0A6P8HJB8"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000303">
        <property type="entry name" value="splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="TOG" evidence="12">
        <location>
            <begin position="890"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031556479.1"/>
        </source>
    </evidence>
    <sequence length="1318" mass="147422" checksum="1EF63FFBBF1F72D9" modified="2020-12-02" version="1">MATLAKAPTTHEEIDKQIQELQARRSDKGLNDDGERVGLGSAGRFDTDIYGSGGDKYAGYVPSIAANELEEDDDDYAATSIMQQGKRQSYTAPMVVLNDMAKGGEQVDPLAEHRRQTIAEREDEYRARRRQMIISPPRLDPFADGGKTPDPALLKQVRTYKDVMQEQDLRRDQAQIVKQIQDKSKAGELQVTQAAPSKQERKRRRWDQQAQGDEAPAKKKSAWDQADISTPSASRWDDTPGRPKGSETPGVTPHRPGSETPGATPSTRIWEATPSHTTPGHATPGHATPGSTTPGMASARRNRWDETPKTERGETPGHSTPGWAETPRTDRTGAETPGATPTPASKRRSRWDETPASQMGGTTPMIGSSGVTPAGAAAMQMQTPTPGQLVSMTPEQMQAYRWEREIDERNRPLSDEELDTLFPKDGYKILDPPPGYQPIRTPGRKLTATPTPAGGTGFYMQQEDRSAKVVEDQPPGNLPYLKPDDVQYFDKLLVDVDESTLGPEELKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPFVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKAVCRSKKSWQARHTGIKIVQQIAILMGCAILPHLRNLVEIIEHGLVDEQQKVRTITALALAALAEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDPEYANYYTREVMIILIREFQSPDEEMKKIVLKVVKQCCATDGVEPSYIKQDILPDFFKHFWQHRMALDRRNYRQLVDTTVELANKVGPSEIINRIVDDLKDENEQYRKMVMETIEKIMGNLGSADIDSRLEEQLIDGILYAFQEQTQEDIVMLNGFGTVVNALSKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAQVMMTCGEEKLLGHLGVVLYEYLGEEYPEVLGSILGALKAVVNVIGMNKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEHVGAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTTLLEDALMDRDLVHRQTACSAIKHMSLGVFGLGCEDALCHLMNYIWPNIFETSPHVINAVMEAVDGLRVALGPAKTLQYCMQGLFHPARKVRDVYWKIYNNLYIGSQDALVAAYPTGQNEEKNNFVRSELMYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJJ0</accession>
    <name>A0A6P8HJJ0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116292794</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116292794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031556006.1">
        <property type="nucleotide sequence ID" value="XM_031700146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJJ0"/>
    <dbReference type="GeneID" id="116292794"/>
    <dbReference type="KEGG" id="aten:116292794"/>
    <dbReference type="InParanoid" id="A0A6P8HJJ0"/>
    <dbReference type="OrthoDB" id="10292997at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027947740" evidence="2">
        <location>
            <begin position="23"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="359"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031556006.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="64945" checksum="01B0EAE7A537BA71" modified="2020-12-02" version="1">MDLKGIPLLFVLIYYQLCLNSALNLVLKTSPPSPVYAAVNTELVLDCTQKGNDDLITLQWTSPKNNEVYSTTSNGSFTSLVFPKLNYSNESVYYCQAVNQTTGLVVAQTNITVNVGDPPAKPPPPTLKRICGYPPTVVIFSYQYPSLTSKSTHYPVIVELIVSPISTTNPCLRVGNDFEVVEESKRIIYGPKNDSFEVNVVQIVMEKVPDFPICNDDYSLIDCKLLCTSVRATNAFGTRFSQTKLTKLVEKCGKIADLRAINIGRNNFTVAWGLPWCLRNSTQFYRNSYYLIQCEPSCGDYIVKSDVRVVSGLNHTISKLIEYKNYTVFASCSFFMHLEDFGERVSISVQTKEGVPREAPTIVTIRWQSECADSNGTALISWKVPNKATLFGKVRYYIVEYQITKTSIRATRNVPAGLHQLLVTGLGMNKSYEFTVKVCTSGGCSKAKQYASLSPNRCTSSDGPAPTPDRLYVNVYPKLHVWMISIVVVIIILAIVIGTLGYCVFLKKHSSRLNLQRIVPIGDIHLTVTGEFSYQAKPIDSDYACAYGKISPLNDPAFLANGPQELILSSTCLSRSSSVLTCNTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLS4</accession>
    <name>A0A6P8HLS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mucin-5AC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116293413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nematocyst</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556696.1">
        <property type="nucleotide sequence ID" value="XM_031700836.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HLS4">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="GeneID" id="116293413"/>
    <dbReference type="KEGG" id="aten:116293413"/>
    <dbReference type="InParanoid" id="A0A6P8HLS4"/>
    <dbReference type="OrthoDB" id="160294at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042151">
        <property type="term" value="C:nematocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0166">Nematocyst</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028355102" evidence="11">
        <location>
            <begin position="32"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="465"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="14">
        <location>
            <begin position="542"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="14">
        <location>
            <begin position="916"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="14">
        <location>
            <begin position="1390"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031556696.1"/>
        </source>
    </evidence>
    <sequence length="1848" mass="202443" checksum="AACB79BEBC590252" modified="2020-12-02" version="1">MHIRFRVIPAVLSSWLLIILTVHLTAPITDASVNVPGAFEREIDNLAALAREQRSVEDLVPAEDKPLQPRSKESKCFLESRPSEGVFKRVDALFDFADRAEGECQRHLFSLIEEQANGVDISKKATHQECLAKCSDSEESKKSCSIFLPNSDKYYHKLVVKSKTTGRRFGVCVRTTSFDAEDNRENGIFNSKKECKDACGFSEKDTSSQKRSQVPTLNKRSGCELYPCENDGTCVNGTCVCPAGFDGNLCENKKCNPTCQNGGVCQNGVCQCPGGYTGSSCETAVCSTPCKNGGTCKDPQRNTCQCPSGFFGSLCEHASCVPFCENFGKCVRPNVCDCAFEYTGPRCNASKCAHDPGNXGDCKLNATDMVYETICIPGYSGDGCTVKSRCNMNVQPGYSKLIVDKILTTAGQNVNNLDWTGNSDSTSTCLAFLKTLRNACNGTSLTLNQNICEANCIPAQTGKVCDRLWNPAKYNYGSEYFVSKWYHDSTTKSCKTFDFLGCYANDNSFNSESECRASCVEPVATSPPPPPTYHPTTPDEPGLCVAHGRAHFSTFDHTDYAFYGICSYLLLYINDPNINFQVILDNDPSCDINSKCKKTVKIDVAGKIIELLPKVGNTQIVKINKNIVKLPYKQEMPSIREVGDHVIVQTSDNIFIYWDGYENVMIKLPDSYKSTAAEQKIAVKGLCGNYDGDSSNDLTGLDNKLYTKKTINDFGKSWLHDTLCTKEPSKPQTCFTLPGESYEDALNRAERICETINSAPFQPCHPKLSSKEFKYMCIADVCACNTTARSDCPCNALAMYSRACAWSHNTTLAWRSPSLCPVTCPTGMVHSECGSACPLECTNLNNDPSKCQSKCLDGCHCPTGEYFDNGKCVAKSKCSCHHSNIRYPHGSIRQSECENCTCNGGQWNCQKIPCKGTCSVLGDPHINTFDGRSYNMHGRCAYVLSEHCHYSAAETKKFSIVLKTVNCQSDAACSRQLIINITGAALITLGSTKSGNNFLPTITVENGNPKTYYSKLVDIEHVGQQTVQVHAVIGFMLTWTGYNAYLTVKPGLEGQTCGLCGTFNHNAGDDFHTRDGDTEVTAIAFSKEWMLPDSAQVDPNCHRTNWANLDNPCSLYSSYRTYANDSCSHINDVNGIFKHCHRYIPPNDYFQKCLGDGCKCKDCLCEVVSAYARACAEKNIIVNGWRNIITDCASKFKCEAGKVLKQCNKDPATNQPICPLTCNDLSKVSQTCSSRGCVEACYCSTPGHYLNNEHKCVPKTECPCYHNDKVYRYQEVRKEGCNNCTCVGGSFECTNVNCESMCQAKGLVYSECGKTCKNLNEPSNCQAGCFCAAGLVMHENGTCLPVDQCQCTHNSKFFDKGAVSPIDCSRRCDGKRNWAQTPGIQSQPEYECSSFGQGHIETFDGMLYNFDNAGCSYKMVDHADFGLVVKKKKCVNSFELQMCKEVTISLPKDNVEIVLMQKTFTIKRNNVPSTYNPGEYPPPCKPVMEGNIDSIEIFQVGLFLIVRIVDKMNPKLTKFEIRFDQGTRVYVTANPIYKNQLKGLCGNFDGSKSGERLSSTGFIASSVPEFVNSWKTGDDCENSKQISPCDLYPDRSAWAQKGCNEIRNNPNFTICHDSVDPDEYVKACEYESCLCHEGGDCACFCSAVAAYVRACNRFGISITWRREGFCELPCCRPCKNTGGYIANNTIPHTCEQNPQDCSKVGDRCCRGARVEGCSCPNNTFFDGKKCVPLNETCENPCSSTSTISTISSTTVVSSTSLTSSVSTTIISSSTISTPTISTSLSSTISSSSTTISSSSSGIVSSSFSLITPSSSTPTLTTSFGTSFPSTSSSMVTSTPTTTVVTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMX5</accession>
    <name>A0A6P8HMX5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116293078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556333.1">
        <property type="nucleotide sequence ID" value="XM_031700473.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HMX5">
        <property type="interactions" value="2779"/>
    </dbReference>
    <dbReference type="GeneID" id="116293078"/>
    <dbReference type="KEGG" id="aten:116293078"/>
    <dbReference type="InParanoid" id="A0A6P8HMX5"/>
    <dbReference type="OrthoDB" id="6022262at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031556333.1"/>
        </source>
    </evidence>
    <sequence length="1298" mass="145482" checksum="D0D1A9CD5A7A98D4" modified="2020-12-02" version="1">MDTDALCSPVLLQVHSLHVGSVCLASLGKQEFKKITGHSSTAVTSLLVPLCNPIPAIRKGAILCLKSLRSSFTLLPPVGTFVDLLVESGEELEADHEHLQRLLSLAFSCLSSSPAKNSQTKSRKSEEEMVLAGMLEYVVGHTVRKETPIYVQKTLLTVMSGVITQPLFESCIPALEKLISKSRTTGLSKDENTCLSLLIQKFSPVTADMLESEPRVWHIMKTILDLRVSVCPGHPPPIVILLTQINNTFFQAIPSKTIQQEILSTLLDILLHTKNDTINSKVKDTISQMKLSAEHVMEELCKLKTEKELKTPKKKKVKKSPVVEDLQSVETASWQRVIIILELLQHLAVTDEQLILPALFSILARCVEMDSSSPVNYDYIMQILLGQILSICQRVGKDGKHDKKDNNLPEDKFNVELIVQCIRVSDNPQTHHHALLLLAVAANLFPEKVLHNVMSIFTFMGANVMRQDDSYSFQVISKTVDTVIPALIQAGERQQLPKLDSKGSPAVSLDDIVAMVIRVFVDASPHVPEHRRLPVFSHLVSTVGASRFLHVTLVLLLEKYVIHSPETEEEEDGTVHSPLDLDFCLSLCQEFEPEIQAEGVLKLLQYLTKLPAEKTDVPHRTRSNRRSTALFSTSSPLFDVQAHTAKHLRQFKFIAMGFISTVLSSDGFVSQLQEQESHVKDSIQNIYLSLIEEVLTYVTTTSQYAEGQTQGTAGKFWRALLHRTYDIIDKVNQLLPPGVFVGVIRQLLSNSNSTVRRKAMELLNTKLGHRTIHQQTQVDEFIQLVEDLLSLVKTCDNSETPVNRQTALYSLKLLTRTLGEQQPAMFTKVLETCIEVFTNKNENSQVSSNALLCLGEVCTALKANAISYLPRFMPRLLELLQTTGQDRNVLILLCSVVTLHKVTETLPNFLSPYLVSILQRVTCPSLNTLNNSEKDEKKSSLEVQLQDNLSALRKDIAQVITARVLIPAVSICYDSIVNTSHVSIPLLIGIVHEAITCMDKRDVTSHQEPLFKFFLVVLDFRVVEPQCEPDILEDVESIVISTICGLVIKMSEATFXPMFLKLVDWATRGNADRDRLLVFYRLCDSLADKLKKLMVLFAGYIIKNCALLLDANNITKTEEPFYVVQGVQDKQASSDHDKSCLLINNIMDCLQKCLLHSTRGFMDKERFNCLMQPLVDQLENQMGSTSEFQERITNHVVPCLAQLAVAAGSDAEWKPLNHQVLLKTRHSSPQVRFAALKALEEFYRQLGEEFVVHLLPESLPFLAELMEDECPEVEEQCQHVAQQIESIIGEPLQKYLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN93</accession>
    <name>A0A6P8HN93_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116291154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554140.1">
        <property type="nucleotide sequence ID" value="XM_031698280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HN93"/>
    <dbReference type="GeneID" id="116291154"/>
    <dbReference type="KEGG" id="aten:116291154"/>
    <dbReference type="InParanoid" id="A0A6P8HN93"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000018">
        <property type="entry name" value="3'-5' ssDNA/RNA exonuclease TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031554140.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47189" checksum="198247478A61629F" modified="2020-12-02" version="1">MAGNQKFHISNLSPKSTKESLAKYLGLDATPYLRSSSWVDLPLDKSGKSLGFAYVNVPTHLGTHMTDLNNTKYMDKRIVVQPVYGKGSQPSMYSSPNVFVPFDMANYASGAWPRPGNIRNRRYGGHPISYEQVSIPVEKKLALIDVAINLTNKIFSLDLDFVLDRALNAGIEKMILTGNTIQMSDKAVLLANRHPGFIYAGVGIHPHFAEKQWNAKTLEVMKRLVSLPEVVAVGEVGLDFHRNYSKQENQIEAFEKQVELACEFKKPLLAHERAAHQKFMEILSKFRGRLPPIVVHCFTGTKQEMKTYVAMGFYIGITGFICKEKVGKNLREAIADCPLDRILLESDAPYMIPNAPITDLDSVCRSLISKCKTGRNEPCTLPVVAYTVAKCLEVDVEEVTKATMDNANRVFNLTNTTPVDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNL4</accession>
    <name>A0A6P8HNL4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fanconi anemia group I protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116291259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554270.1">
        <property type="nucleotide sequence ID" value="XM_031698410.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HNL4">
        <property type="interactions" value="1853"/>
    </dbReference>
    <dbReference type="GeneID" id="116291259"/>
    <dbReference type="KEGG" id="aten:116291259"/>
    <dbReference type="InParanoid" id="A0A6P8HNL4"/>
    <dbReference type="OrthoDB" id="195089at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11720">
        <property type="entry name" value="FANCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029310">
        <property type="entry name" value="FANCI_HD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029313">
        <property type="entry name" value="FANCI_S3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029314">
        <property type="entry name" value="FANCI_S4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14679">
        <property type="entry name" value="FANCI_HD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14677">
        <property type="entry name" value="FANCI_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14678">
        <property type="entry name" value="FANCI_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1" evidence="2">
        <location>
            <begin position="65"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 2" evidence="3">
        <location>
            <begin position="379"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 3" evidence="4">
        <location>
            <begin position="808"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 4" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031554270.1"/>
        </source>
    </evidence>
    <sequence length="1369" mass="153124" checksum="B41A64D86AC9980A" modified="2020-12-02" version="1">MNKNIVRLADEGNVSALTKTLAEVQLEELGEILEERALEEKADTVSFIRAVLKGSSCNTSDGLKRTMYMYKQTIKLLNNGEITNKVSTDIVGFLLMELDALPGKALAELADVFLDAIKEGSVSGKSLELLPKVLSAVAAKESVPLTTDCGGEMSGPEYKRQILNSLCSSRWDSQCVIHLAAMFRDVPMSSEELRFVIDKLQRMFKELDLQELPPLVYQLLLLSTKGHKNLVLQGVLSFFNEQDEACREEEKAQNHDGVQSISKEQLRHMEGTIILHITFAIKQDQNLGKELIKFLKASQSSPGKILTPFTVALSLSVAQIHRFEETVFDILKSSILRSFKDEERQRQSKWIKENIPECFKVQDFILETVQNSLFGWDHVTQGLVQLGFLLMDSYGPRVFETHALEHLSPTQQACELGSKVLLNTFKGHEMVRAEILEQILNRVVTKATTPVGHFINLLSSTVRSAPHVLLESLPKVKEALDYLSFLPPRTAEGLLKALQPLMKISLSLRDSLILVLRKAMFSRQVDARKIAVTGFLQLLKHFKVLGSGGLGSSQASSQASVSFSQCSQVQVDVHIRGGAGNEALCLEILGNLRRCFTQQSDVRILLYEGLYDVMCHNPQLRQPILDALYVQFQKYYETEDDVTPPIKLDPCLSASGEQVFLAEPLAHLLSALQHCTLWCGDHTSEEDDDQDNVEHLFNEVEDLLQSLTRRMIKSEMEDFELDKSADFSPTTSVGMKNSFLANLVLGVCELLLEFTFTEGEFSTQSIEEVTQLFAVYHQLEDILKEKSVVQGKKSRPWGSKQQSSSTSLLSLGCVAQLCTALFSDLTPSHQQGLMPLRSVADFVRYVLNVTLQKLKQISESGTCSGPRGRNKEHIYKQCHSIARVFLKHVSGNSCINDDRVKKDKSKKLSSLCLEGLCIVVNIVCCHYKDKLSHFLAIIDLSGESRSDQIDQDDEQEHIYSTIKIFQQLIISIISSDTQDSDISVKDTHTLINVISLLTHHLDPDSQQFAHLQCWVQRICKEHNVDDMTLSKALVTLLFSLTFQSKTGTSMIREMAQDIHSQLGDVDEEIEVENRTHFAIVNPRTAAPTIALIVVNQMDKILDELDWTMSKIRGDLAVTQSTPSNAKMPDSPDNTQRTTLESAVCVRLTGLVMALHELSQSALPEGPCTESTVKVLTKLYVTLATCGKYYMALYNQRLGHLPPKFEKLVKLTGTHLSQQVYAMITYIQAVQTQSLQEMAASSKGKAKDKKRAQNMAGKAKVMKEMKSIPNLIYAIEQYEKFLIQLSKKSKINLMEHFKRSTARDFRINGATLEAALRDDPSDEEDEDGSESESEEPPKKKGKNEEGKPRGGKMSLKQKKAAKQALAVPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNS4</accession>
    <name>A0A6P8HNS4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116293405</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116293405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gasdermin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031556688.1">
        <property type="nucleotide sequence ID" value="XM_031700828.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293405"/>
    <dbReference type="KEGG" id="aten:116293405"/>
    <dbReference type="InParanoid" id="A0A6P8HNS4"/>
    <dbReference type="OrthoDB" id="9436533at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040460">
        <property type="entry name" value="Gasdermin_pore"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042377">
        <property type="entry name" value="GSDME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15207:SF3">
        <property type="entry name" value="DEAFNESS, AUTOSOMAL DOMINANT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15207">
        <property type="entry name" value="NONSYNDROMIC HEARING IMPAIRMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04598">
        <property type="entry name" value="Gasdermin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gasdermin pore forming" evidence="4">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031556688.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52185" checksum="649780805D7AEC65" modified="2020-12-02" version="1">MALFESASKQLVKDTGRSSLHPVLDLNSSSKYGIMCVVEKKKSRWFWRKTKYLPTPFNLNEILLQPIDYSSTVKTTEFVANYENDPSLHVSGKLGAKLAGELGIDVSTTDSFTVKINLGTINKSKIRWQELSNLMKDKKLNLEHEFVQAILKSKRRKLCIVNEVLKTTKETNIQSVLIVEGDADAKASATTKAEVDVKGSVSDTHHHSFDIPKDTIXAYGCYEFDFDDGIGMIDLAIEKKLEDVTDAAPSDETTVDHPDGQDSALTSIFHGLLKSPKKDDVIKCFKQILATPESIKPLDELLEKAVYSVEGEMVKPYTFQEFKSLVEHCEGWEKLLALLGFTIEKEKDGLIVYPDEEALDLILPCSALADALNGLSSQQCLALKDLKHEHAEPLLYLIKNAMYGRSTPEDDPQLKRIYSHAANPGKTFLLTLGFVQTTEDGKKVLTLPPKHFIPLEEAYVSVFVMGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPB6</accession>
    <name>A0A6P8HPB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Uncharacterized protein LOC116291469</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116291469</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554500.1">
        <property type="nucleotide sequence ID" value="XM_031698640.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116291469"/>
    <dbReference type="InParanoid" id="A0A6P8HPB6"/>
    <dbReference type="OrthoDB" id="5983314at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000016">
        <property type="entry name" value="Polycystin family receptor for egg jelly"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ71</accession>
    <name>A0A6P8HQ71_ACTTE</name>
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        <submittedName>
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        <name evidence="13" type="primary">LOC116293887</name>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
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    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
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        <subcellularLocation>
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            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="168"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557243.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="50353" checksum="E1AAB1BE17BD8E70" modified="2020-12-02" version="1">MIGGLFIYNHKGEVLISRVYRDDIGRNTVDAFRVNVIHARGQIRSPVTNIARISFFHIRQGNVWIAAVTRQNVNAALVFEFLNRTVDIMMSYFGKVTEEGIKNNFVLIYELLDEIADYGYPQKTDTAILKTFITQQGVKTQTREEQAQITSQVTGQIGWRRENIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSFLSGMPECKFGMNDKLVVEKQSSKSSSSDSSLDTTLGSKKNTSKTGIAIDDCTFHQCVKLSKFETERSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRSRMEVKVVLKSNFKPSILGQKIEVRIPTPPTTAGVQVVCLKGKAKYKSSENAIVWKIKRMGGMKESQISAEIELMPTKDSKKWARPPISLNFEVPFACSGLKVRYLKVFEPKLNYSDHDTIKWVRYISRSGLYETRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSB3</accession>
    <name>A0A6P8HSB3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Polycystic kidney disease protein 1-like 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116292381</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555550.1">
        <property type="nucleotide sequence ID" value="XM_031699690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292381"/>
    <dbReference type="KEGG" id="aten:116292381"/>
    <dbReference type="InParanoid" id="A0A6P8HSB3"/>
    <dbReference type="OrthoDB" id="2121937at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF150">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027635995" evidence="18">
        <location>
            <begin position="30"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1420"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1628"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1668"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1726"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1773"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1841"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2110"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2141"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2199"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2237"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2296"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="19">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="23">
        <location>
            <begin position="412"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="22">
        <location>
            <begin position="1258"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="21">
        <location>
            <begin position="1463"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1945"/>
            <end position="1961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031555550.1"/>
        </source>
    </evidence>
    <sequence length="2550" mass="286677" checksum="C97170DCB2924DD3" modified="2020-12-02" version="1">MTTVVMHSQISRILLAMVVAFSCLAKVAPQGWHDCRKPLGMVSGAILDQQIQAASVYNNETTYGPSFARLGFPGGGYRADPNADQAWIMVIFTKPTIITGIATQGFGDERIQEWVDKFWLGYSDGAVNSYFKDVKGGKQAKQFDGNKDSNSIVRNDMPVPESVITINIMPIKWNKNFAIRFELYGCLADGYECLSTPCQNNGTCVDMVASYHCNCTEGFNGTNCQYNIDDCASSPCKQGGNCTDLINDFSCDCPPGYTGKTCNIDINECLSSPCQHGGSCKDVVNGYECTCVRGFGGKNCEEETGFFLIIWLQIKGKTFTMDFMDRSSAAFNTNAFQAKQQITSMMSLDEGFLSSDVRRFSPDSFLVVEVLIECLRNSTGRIMDSMERNIVNGAGIFKNDYIKFGDTVNLYCKPPDVKLPFLKTLQQATHISRHMTFTVSMTTDLSCVASNYIASYKAAIYSISNVTGSLQNVYQTFGNLAQNATIWKIPAKTLSYGKYYVKVMSVIENKRGAQSSDFGFIVVGETPLVSRIAGASLVYQGIKEIVYLNGSGSYDPDIGPGHYDGMEFIWLCRRDNESFKGDPTSLPVVTPSSNQNADLGGCYGTGIGRLESSPMENYSSGLDIDRMEGNTKYVIALLVKKGERSKWSEHSIYVKEEIDIALKCIQNCRQRVIPSGRLIIERTCEGLLCNKIXSYAWDLQYLDSKTQKWLLVPNFADYILTYMNSPNLVTKESLLRGNTTYLLRLTAEAPGGIADTTSYRFVTNSPPTGGTCDVDLQEGEAWLTFFSFTCSGWQDVDLPLTYKFRYNTSDGIEMVFFSGRSSSARVRLPVGDKMDDMKLHIQILVLDSLGSATSFWLHVRVTEPVMSSISIEEAVGKQGEMNQYLQDNNIELAAQRATSVLSVVNNASPQEISLVKKIKIKDAIVKAWSNVTVSNLEEIGQVSAVITGVSDKNDEVSFESQKTILTLLGNMTTILESEVSNKAKNDGNEQSIQGVGSSLLHGVGNFIEIAAINASLTEKKTGKTRQRRDTESEYGNTESISMVQKAVQLIDQXGSSLEQTKELYEKPSVFKTKSLSMVIDRQKPELIGGKTLREEGMMISLPAAEELLRGEDAGKEEQISSQLVSLTGNPFTWDTXAQHVKSSVLDFKLRNANGTHMEVNNLNKDFELFIPVKNSGEYPPDNEESYFVKPSVNGSMQYHIINIPGDEYAVSIKIKPLSAVNLXLYVRYGSRPTVHENNYTAVVPNFESCNFTRLEGFHNCTSDPYTVTISSAVTGHMGLHYIGILYKIFSVTSENRTEVRMRVRRDCFSNGGRQRRSLCVGVKDPPPTESTTDNLLLTYDPHTDVNYTMSVSIATCLFWNTTQQKWTSYGCRVGSRSRVXLLHCRCNHLSSFGGNFFVAPNPIDFNKVKQRFIDFDPENFVVFFVVFGIFGLYLVALVIARRADRKDEVKATETLCLSSSNXHLFEISVYTGMWRNNGTTANVXAIVYGQNGQSDVLPLNDRYSKRKLFARASVNVFMVSLPDTLGPMVGIKLWHDNEGSSPSWYINQIVIRDLENDVKTYFVCNRWLAVDKEDGEVQATFGVSSKEELSSFKYQFYSRISKSLGDGHLWLSVVTRPPHSPFTRSQRVSCCLSVLYCAMVASAMFYQFGEKTKDTIKFGPLRLSVKQLMIGVQSALVVVPINILIVTIFRNVKFSNNINNLRRNSYLPQEKNEKSKQKTPGCLPHFFVYIGWFLCMASVITAGTFTIIYSLSWGGETSNQWLTSILIAYVQDIGVIQPIKVVSFAVILALIIKKPVEEKTSHSMKKADLEVNTKVTIVPPEGEKLEEARTYRKNIVETLRAVGEIVFYLMFVTCLMVFVYGNRGYDRYRLTKSIDDIFTSSFKEISSSQTLWEWSRTSLLPGLYDTTWYRPGGPRMTEGYISSKEAFLVGMPRFRQLRVKTESPCEVDNYFPWSGFHFNRCILPYEPQNEDRTPYNFPRWVPVKNISTYGSLFDLMRLCPKPWRYKSSKELNTFDIQGVNGEYDGGGYVADLGYNMETALGVINDLQSDNWIDRQTSLVILEFTVFEPTSSLFSHAKFIYEVSPSTGKPILSVKIETLSLYESPNSSLRSVMSVVQILLLVFIFVYLISEVGKIMELRCKYFASFWNWLNIVQLLSASTAVVLFFFKANYVSRFIKQIQSNPYQTTSMDYVLLWCNLELYIISVVIFVVTIKFLRLLRFNRHICQMTASITHSSGHITTYTFIFLIDMLAFGILGVLVFGHTVKEYSSLVESLSSLFQKFLGGEMIFYDLLSTNRIIAPLFVFLYMLSMTFILVNMFVAILNDSYESVRHISGGKFPDSDLGSFMREYYRKRFRGTHDILKRKLGRFGYRAKKYDPQXEEIRGSHEEDNCISYTSLSSQEFSSHVNLGFSSESLACPIRREDLVPKELQPKPADTPEISFPVTEAESLDSNDVAMETATTVSIATTSTTPELLDLISELPESLVDDEDTVDIVREKLSNVGAILRLSKRTYRRFSTTGDKFVVERDFNIKPAVQIYFTPETHRKHKVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTH8</accession>
    <name>A0A6P8HTH8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116295881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_031559699.1">
        <property type="nucleotide sequence ID" value="XM_031703839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTH8"/>
    <dbReference type="GeneID" id="116295881"/>
    <dbReference type="KEGG" id="aten:116295881"/>
    <dbReference type="InParanoid" id="A0A6P8HTH8"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031559699.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35125" checksum="1A18941EE54CF198" modified="2020-12-02" version="1">MELDVLKQKSIDAYKRIRSNVRHTAIDYSPWLSALGEANVYIKWESEQITGSAKARGAFNKLLTLKEDNPDMIEKGAVAASTGNHGAACSKAMHVLGIKGVIYVPAMAEDFKRKMIEQFGSTVEQYGHTCAEAESKARAVSQEKGIPYISPSNDWDVIAGQGALGYELHQDLPEIDVLFVAVGGGGIIGGMAAYLKSVKPSIKIIGCETDQSPVMSESQKAGKILEMPHKDTLSDGTAGGVEQGSVTFNLCKRVVDQWVVVTEEDMSRAIYNVLEHHHKIIEGSAGLAVAGYVKTKEQHVGKTVAILSCGSNISIEKIKAIIKTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTY8</accession>
    <name>A0A6P8HTY8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8 9 10 11 12" type="primary">LOC116295112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031558703.1">
        <property type="nucleotide sequence ID" value="XM_031702843.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558704.1">
        <property type="nucleotide sequence ID" value="XM_031702844.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558706.1">
        <property type="nucleotide sequence ID" value="XM_031702846.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558707.1">
        <property type="nucleotide sequence ID" value="XM_031702847.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558708.1">
        <property type="nucleotide sequence ID" value="XM_031702848.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031558709.1">
        <property type="nucleotide sequence ID" value="XM_031702849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295112"/>
    <dbReference type="KEGG" id="aten:116295112"/>
    <dbReference type="OrthoDB" id="5962126at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031558703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031558708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031558709.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48208" checksum="276D93D006BBC9B6" modified="2020-12-02" version="1">MRRRRTAQQQTTGKPLRVVLLGKDGVGKSALTVRFVTRRFIGEYDQTLESTYRHTLQIENEDVYVDIMDTAGENTDGKIRRYTRRGDLFIILYSIVDRSSFDEARSIAKYIKDHRNIESMSMVIVATKKDLDHLRRVDIEEGIGFSNELECTFYEVSISEGYIEVQELLKELLKRVLSQKNDRKDTLKIPSISIKRSPSLERRKWGVGMFEKPKSYFERSEEESSPDGTRNPGNKSPEITRRRKDSNNNIPEQLKSLQELHGSTSPEETSTKYRFMSKNNSPVSQRKKNPFAIEKVKGASSANKLKLQKIEDXNKTNQKPKMFALQKVRSGSGNTELGKTTGISPTERSVTCTENNDNSDVVERSSDDKPKGPFLLNKLHSTSTDKLRSNSSHERLRATTSFGRMRSGFERTFGRKKAIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUT3</accession>
    <name>A0A6P8HUT3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116295397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116295397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559053.1">
        <property type="nucleotide sequence ID" value="XM_031703193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUT3"/>
    <dbReference type="GeneID" id="116295397"/>
    <dbReference type="KEGG" id="aten:116295397"/>
    <dbReference type="InParanoid" id="A0A6P8HUT3"/>
    <dbReference type="OrthoDB" id="73209at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31535">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31535:SF3">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028342458" evidence="2">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559053.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="56254" checksum="9E3CA2D1E5EBFE2B" modified="2020-12-02" version="1">MTRAILSLAFCCIVGFSQGFFLGGNEKDSIGIPVQLDKLGFRQDAKVYSHLVIPPWSRPFKPGYCMSWEWNTDKRYRDQRLAICQELTKGKHECDSPGGCRDKCPFSNGTYPYWRLRNAEDVPFLWVISSLQMYETPFSNRPLTSDPSRGYASSYFGPGYKPSNAFDNNEDTLWISNGAAPPGMQWIAFEFERPVFVGSIRMALEEGKPERSPSMIYVEASCEKYFRNFVTMWVISNPRREADKRYSVFGEAKFTTLGASGRLGPVSVGTHYKGADHEGKVNVNKGVQMWKVPASGTYSIEAAGASGGYDKFSAGSGKFRGRGSRVKGNFKLQKGDVLKILVGQEGSSNPTSGGAGGGGGSFVVKEDNTPLIIAGGGGGVDKLKGESPRCHGTISQDGNPGYGGSMFQGGSGGRGAEEGDNGYSGGGGGGLKSNGRSNRNFGGSKGTGGEGGKSFVSGGVGGRSNQNHVDGGFGGGGGPNGAGGGGGGGGGYSGGASGSRSNSCGGGGGSLNKGTEQSNKQGANNGHGYVVVKLVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWP4</accession>
    <name>A0A6P8HWP4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116295977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM147 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559798.1">
        <property type="nucleotide sequence ID" value="XM_031703938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWP4"/>
    <dbReference type="FunCoup" id="A0A6P8HWP4">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="GeneID" id="116295977"/>
    <dbReference type="KEGG" id="aten:116295977"/>
    <dbReference type="InParanoid" id="A0A6P8HWP4"/>
    <dbReference type="OrthoDB" id="9993532at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031559798.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25690" checksum="2B411D57BF076239" modified="2020-12-02" version="1">MTLFHFGNCLALAYFPYLIVYKCSGMSEYSAFWQCVKAGGAYLVTQLCKMLVLATFFPTSEVPPDSMDYIGEFLRSTVDLADLVGLYLVMSKVAGKGDLKVLVAGLGWATAELSMTRLLPLWVGARGMEFDWKYMQMSFDANISLAHHIATATLVWLWGRTDLHKTFLPVVMVFLTLGCYKPLIIEVLSHTFGVQSWALLVLKASFTSCIGFVALQLYLALTTDQKQHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX70</accession>
    <name>A0A6P8HX70_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC116296108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116296108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559926.1">
        <property type="nucleotide sequence ID" value="XM_031704066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296108"/>
    <dbReference type="KEGG" id="aten:116296108"/>
    <dbReference type="InParanoid" id="A0A6P8HX70"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027996586" evidence="5">
        <location>
            <begin position="22"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="573"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031559926.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="71760" checksum="66AB3E9302455688" modified="2020-12-02" version="1">MMGPLWVAIALLATQVTCSLAACDLSSPLNSTEASELLRNYTDQIRSNAVGNTSFSGVTVLQLVEFALNTTGNTTLTQAKLNWDDTCLDAFKFTLSQVAMINGKELDNFPGNATMDDVRVLLTSNATKAVVQDVGHVLITLRNRNVSLDRNLDFFIQDVGFVIRKSSFLSILSYSLKSSDRKSTVSLLGYDERLENATLGQVAEYLLITPEELQKSLTLEYVVRYLRSSRTFFHMLLEFVKEERDRLAEKTVWYLVNSNEDTNILTTLKGIYQGNNLTFIQFFWERRVELRYMNYTVAELAASTDVQRAVIKNYTILETFEFLYKYTELNLVYKESIAASKNIREKILQHYQIANMSILEDTFNVTTSYLHLLTDFEFENYAIKYYIHRYARLHLNITYGELETFAKLEPGSLKNASVEDFAQLMSQIGVAYAVKALHESGFFKYLLNNHSXLEIHMLLLKQQIEKDRQPLTKNYRVLYQEFEVSYLIYLYRLDTTVFYERTVFNFTETLKLNWHTFLVLFDLNNTXLEEVKLLFKTYSFKQLSIFFGIKEYTIFNWNFLKIINRLLYLXRNRIDECSLGRHSCARRSQCKNYIIGGYTCVCPAGMNVDPDNHCRGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXW7</accession>
    <name>A0A6P8HXW7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCNA-interacting partner</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PARP-1 binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PARP1-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116297180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PARI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561209.1">
        <property type="nucleotide sequence ID" value="XM_031705349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXW7"/>
    <dbReference type="FunCoup" id="A0A6P8HXW7">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="GeneID" id="116297180"/>
    <dbReference type="KEGG" id="aten:116297180"/>
    <dbReference type="InParanoid" id="A0A6P8HXW7"/>
    <dbReference type="OrthoDB" id="6427080at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038932">
        <property type="entry name" value="PARPBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32121">
        <property type="entry name" value="PCNA-INTERACTING PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32121:SF0">
        <property type="entry name" value="PCNA-INTERACTING PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="579"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031561209.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="79489" checksum="05B6E02C870B352E" modified="2020-12-02" version="1">MDADVYCVLEVKGKQDIDLILQRINESSDNENDSNRKVLAMGDVLNSTRSTYGNPNEFLGQCEEHSLLHPLELCVEIYRKHCSKSPPFCNSIYGLTDQLISLQIVMAQKNKEKSGEFEADTLDVISTHQQLIESKLYGLSSVKDPEILQIIEDYGKFLADCNAMDYADIINCVSQCFQASDNNTKELYQNQQYIILGIPTTVFEMEILQLLIGARNIVLLSPNQGKSTITSDKFNEIIKDRFDANKHMEEVVPRTQESVMPSTPVHVTKKQTCQVTPQHQTGTNDRQGSVCLSGGQSPILSQSPFSQGRRTMGQELSVVMSYLQLLLNSRDELALARVINTPDRELGVRKFTKIKRLAREKNMSMYQMVTSFILQIRLGGKSYAPSTENPLWLMTKGLGDFVSFFQKLQNILEEEPDAKSAVTKILWNLQSTFIRGTDGTISKEDVKKAISYLKTQIDGVLNSSAKKHTDELKPEPDKNMIGSESYLLLCTLLDKNVLYDYQEKELSIALKTPSRKQGTTCSLLTKFRSPDAPTPEKVESPGANQNRTTENPEHRKRQGRSVYGDISWANPAVTIETRKSIWQNNDDNNINQEQQTRKPCGMLTTGETPKSSSRKRTFDDTCDTLKDKSSSPLRKRPFESKDDQENIINKQTKPTAKRGLLRMHQMTEPGKKKPQRTNTVPKKKQKSVKLTQGQKQMTHFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HY28</accession>
    <name>A0A6P8HY28_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116294119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557512.1">
        <property type="nucleotide sequence ID" value="XM_031701652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294119"/>
    <dbReference type="KEGG" id="aten:116294119"/>
    <dbReference type="InParanoid" id="A0A6P8HY28"/>
    <dbReference type="OrthoDB" id="5989844at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028310705" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1398"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031557512.1"/>
        </source>
    </evidence>
    <sequence length="1510" mass="172115" checksum="DCB79995B72C26BB" modified="2020-12-02" version="1">MVSVILILFCAILTIAEVTPDVLRVVYVSKARGLATAVCGSTLTPCKTLELGFKRLAWNGTLYVDGKNTDKDPYTCESRYRSAKKGYKIQKSFTLLSYGNSIPRISCSNGIIIEVSTPRETVRVNVSNVMFVDSNRLWVKSGIRVKSGIRVTLTNVLFNNTKLQLKNALSDIRDCSFQRSYPAVFVCISNTLPTYYLKVKNTLFKENCGCIEIYQPKAKGCNREIVLNLKDVLFQGNTILMKKINKNRESGLVSVRGSRNWRCKNMSFLSKWENVTVIDNQGEVKFCKKDREEKPKDCCWKRKENPRDFTRNIFAVSACRVDLTFSKVKSLKNVNMRFLMSQSGYNKIRVDDSIYHGHHIDKPGGVIHVKGQGALVNLNISDSAFFNNSGTLGGVLQVDGGYTKVVRLKMDNVSLVHSHGSDFGCVLSVANVSYNHKSRFTHVATIVANFEGLLVNNTRFSYNTADKERHYAAFCFVASHLSQVSIMKSLFYKNDVPAFILKHNPIDPSLASAEVNVKIYRTDFIENYSRRKNAILTLMVDHSVKKSSLELSRTTFMKNNGTAVIARNVIDLNARNFICSHNSWICMLLKSELRKGRNVSSVNSTLMIKDSVFTHNMNSPIEFYHTMPRFLDIQILNTSFHKNHYRAALNIKIGFKKRSNTLIKGKLQIKRTNFTSNSVDFAGSHVLRFILMVPTKADFKVSIDETLFINNVQHFKGNLPGMSSVLFFFMPEDFELQKQKKCRKFPHFIQTRKMFFKKVVFENNTGSSTILYISNGFNSFRQCLFKNNFAKYPRSGAHVFIEEGTARVLFDRTEFEQTKISNCKPCSDNPCNHSKVLPFIFAGARGPLVIQNSSFTLHASERKSNMFVIQNGRYVHFDSSTKLLCPLGSYINLENSSHVIPPMFTHDSCRLNITRIRFVCQMCPTSTYSLQRGSFRGHSNKTHVSCLDCPFGGNCTWNIKSKNDFWGYLSSSDPPRLRFASCPEHYCYVPKRSRNTSVYNRCAGNRTGMMCGVCKEGYTESLFNHDCRPVNDCRDRWFWVVAGLYSVIMGVYILVRPPIVMQLVKKIMWFKHKTPSMRHTTHEQEGTTHGHGEHGYSKIIFYFYQVADLLMLESSFHILQKEVFIITLVSFYNFQVNIANSSFGCPFPGLSAVTKELFRSLQVFAVMVFLVVLYFLHWLLWSFRRRPRPHFAPYLAAIIEVLLLGYERLAHTSFNLLTCTPLNINGQEVWKMFIDGNITCWVHWWQYAMIAYNIVFVIPFVLVLLVGTPKLRSGHIGPFYFLAACFLPLPFLVYWMLKRILKCDRCIFDAKEEARDEEYTKHLLEVIQGPFRPPQDQSKGALNWESILIGRRLVLLCLHSLVTTPMLRILSMTFICLLILLHDVVIMPFKDGKTNAMAAFLLCIHVVLGAINLAKATLITAGVSPEGPPKTQIHALQLLEIALLGILPCSFMLLVAACVMSQAIRLMFKAGLYLFSKICFQEEGGGRWYPEQNRECLGESYQPLLDPTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYW8</accession>
    <name>A0A6P8HYW8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296686 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560603.1">
        <property type="nucleotide sequence ID" value="XM_031704743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HYW8"/>
    <dbReference type="GeneID" id="116296686"/>
    <dbReference type="KEGG" id="aten:116296686"/>
    <dbReference type="InParanoid" id="A0A6P8HYW8"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044823">
        <property type="entry name" value="ASIL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307:SF4">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="73"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560603.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45972" checksum="D2154F12F8061C73" modified="2020-12-02" version="1">MATSMKQDRRVSELRGVMVPSDMVQVEMHRVPSDMVQVEMQAPRNSQLLLGVDERNVGQRNKQVRTAGVTNSSRWTDVETRHLLEVWGKRYSSLRFKKRNFKDWEIIAREFNKRCETSGIIGLGPRMGAQCKIRIKNIIADYKRMKGQYSGHNSRQLFPFFETIDQIIGNSKQGRSHQANEQYSREEFKADEIVHLDLPEEATEQPTSGDVTIATAAIAVPVSADSVPENTTAIHEQNSTVGTLVGTHMTKPVLSFSTTPSFHPNTSVTVNHVPLPSPQASGIVTQFNVTNPEPRRIPSSFAVSSQLQTFKRSSTGQPYTNTLQKKKLRKNPRPVKVVKVSRQAAEDDKLLAIVREFMEERRKREEELFHKLFQQQAEAEKRYQEFTLNVIKEIGRLFRPEAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZB9</accession>
    <name>A0A6P8HZB9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger protein 830</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Coiled-coil domain-containing protein 16</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Actinia tenebrosa</name>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        <location>
            <begin position="919"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="528"/>
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        <ligand>
            <name>L-glutamate</name>
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        <location>
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="15">
        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29985"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="754"/>
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        <ligand>
            <name>L-glutamate</name>
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            <position position="686"/>
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        <location>
            <position position="806"/>
        </location>
    </feature>
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        <location>
            <begin position="767"/>
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    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031560848.1"/>
        </source>
    </evidence>
    <sequence length="997" mass="112361" checksum="BD22B7E3182597A1" modified="2020-12-02" version="1">MAFLFLLYLFFCVCTEPVKTQSTKRILIGGIFRNISNAESDYEGFRTAIDYINEVEKQKNSMIRFEGIVEFTDSDEDLDNVLKGLAISLVDRGAVAIIGPNEVIHIEAIQRLCPQLRTPQLAPFASGLTQSFNPCDFEYILRMSPSDDLLCNVAADVVKYFKWTKVAVLASRDNEGREALGSFRDFLEDRRIKLLQSELFIVDPDDNTMHHEIRRVLDSILKAEARIIVVRCRSSVIRKVLQEAENKDMLKEYAWIWLVNNFEKEHLFPGGQMSHELKGLIGVRQAIGHGPLGEAINEYYYKNRRIAITKPSVGRIIDSVLVVAKAVRNALQDGFQISSDKRSGRICNKSMDIVDDGGQGAILSSYLRQVTMYGFMGNISFDKGAQKSGIYDVVNFHDNSITKIGLWNTNEKLKMFKNKTIIWNSDSSYVPRDSINTLKNKILTVVTSMSSPFTMLKLDNVTGGVRGRPEFEGAAIDILDKLKEALHFDYVIYKSPDGTVGNFNSRTGRWNGAIGELLNETADLAIGPITISSRRSKVVVFTQPYMTTGLGVIMATEEGDPSFFGFLKPFSVHLWIVIIGAVLGMAVVSFVFSLLSPYGFYGRCVQSTSNEVKASHLETQYNLSLLNSIWSSTAYYLGQGPDGLHPISASGRAAIAVWWFCITILTSTYTANLAAYLTTNRMQTPIAHVNDLSEQNEIDYGLIENSQTQRFFEDSRLSRYLIMWEYMKLRRALVSNTSSGIQRVLKGKYAFIHDAPVLQYQARKNYCGHIKLIGGFDEKTIGKMSYGFALPKGSPYRLLINIELLKLQQKGVIKKIIKKWMIDKTPCSLLDDADLHEESKTDAYRMGLMNMLGVFIFMLAGVVIGLIFLIIEWWAAAVGDSKRAMRHLPFMRAIQNRLSSFFKHVKNPETKKLDLSHPRSATRSTQTKNPSEKTSMHYDHLHDRYRPVTQAIAPSKATGVPRKLVKGMRANKPRPKLQSMVVSPSMKATKRWPSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I0K1</accession>
    <name>A0A6P8I0K1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Collagen alpha-1(I) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116294868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031558407.1">
        <property type="nucleotide sequence ID" value="XM_031702547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294868"/>
    <dbReference type="KEGG" id="aten:116294868"/>
    <dbReference type="InParanoid" id="A0A6P8I0K1"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028029175" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="6">
        <location>
            <begin position="1224"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
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            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
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        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="956"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1156"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558407.1"/>
        </source>
    </evidence>
    <sequence length="1413" mass="136646" checksum="0ED3ED1116649AFB" modified="2020-12-02" version="1">MVTSRPPILVVVALLCAICILVHAAPSGDDLELLKLKLDKSIERSSRQRRQAPSRNTCYCKPGCNCDCPAGIFCNATLPGVGSNGRPGLRGRPGLRGQAGERGVQGPGGDIGRAGNRGNAGAPGTIGVPGKDGPPGITLIGAPPGTVLTQEELEQILQIWNSMQRQIRSGLRHVGRVGPSGRRGAPGTPGEPGLDGEHGEQGLKGNRGETGPPGPPGPPGDPGRPGKDGSEGLPGRPGLPGKNGEKGDRGVQGRFGMPGTKGPRGRPGRQGQKGRRGITGEKGGQGAVGKSGKPGEQGVQGPRGLPGPAGSPGIKGSTGLRGVQGPPGPKGSVGVPGPQGIPGSLGARGEAGADGSPGPSGPTGDVGNPGPPGPSGDRGAPGAAGADGVAGEKGSPGSQGPMGGIGISGGLGPKGNEGRGGRNGRKGDKGPSGIKGTKGNRGPKGDKAPDGASGEVGVPGVAGAPGEEGRLGPVGPVGATGPKGVQGSPGYPGANGGKGDKGNRGGRGRRGSRGARGDPGPTGIDGQGGVAGPRGVRGAKGKPGSPGRPGPPGYPGNPGQPGTIGGAGPDGFKGPPGAAGTQGPRGAPGSQGAPGPDGVAGQTGEAGVTGPEGLPGPQGPQGPKGNAGAAGDKGVIGKQGGKGEPGEKGDRGPDGSQGPLGTPGRNGENGVDGAPGEDGTRGNPGAAGPQGLRGIPGAAGKSGEMGPEGPAGPRGKSGPGGPQGPEGAVGPPGANGAKGDMGPDGEQGPNGNPGATGPDGNNGNAGPVGAQGPKGESGEPGLAGVAGRDGPRGQRGSAGQPGQPGPPGPIGGAGEAGARGARGKMGPSGDRGDMGPTGPGGLPGPQGEQGDVGPIGNKGDRGPQGSAGAPGSQGERGSIGGPGSKGPRGGKGEKGPDGKDGAKGSTGQSGPDGESGQNGAPGPDGAPGKDGAKGQPGQQGPVGKPGPQGIAGSRGQSGFPGPQGAAGPRGEPGERGDNGGDGRDGPPGPPGGRGPRGPKGKRGSTGTPGLQGLQGPRGGVGINGGKGDKGDIGERGMRGGAGPIGIIGAAGRQGAKGRSGRTGAKGQGGDQGIDGDRGVTGKSGEQGIKGMSGELGVRGIKGYRGNMGQIGPRGPIGLKGDAGEEGLRGSRGPKGPKGFKGEPGPPGVHGDQGPPGKYGGVGDKGARGGAGLKGRRGRIGDPGAPGPPGPTSDSLFGSRRSGGEGARGNGRQKRSIEDEAIKFNEVVIDAIVETSQAFQKIVRPSGARDSPARTCRELMKTNSQLPDGTYWLDPNQGVTADAFRAFCNFTAGGQTCVKPINRLVRWNSNVNSNTLFSTVKDGFKFSYEANTVQMKFLRLLSATAAQKVTHDCIQDIQLLGTNNKEMPNEHTRCKTGQRNVQNLQKLELLPLRDIALSKANGQLQFEVGPVCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1I5</accession>
    <name>A0A6P8I1I5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116297539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561648.1">
        <property type="nucleotide sequence ID" value="XM_031705788.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I1I5">
        <property type="interactions" value="1399"/>
    </dbReference>
    <dbReference type="GeneID" id="116297539"/>
    <dbReference type="KEGG" id="aten:116297539"/>
    <dbReference type="InParanoid" id="A0A6P8I1I5"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000001">
        <property type="entry name" value="RNA terminal phosphate cyclase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031561648.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41224" checksum="57AA734F3F0D86A4" modified="2020-12-02" version="1">MADTTLVYEGCNYFRLRLVLATLSSRPVRIKNIRTDDDNPGLKDFEANFIRXMDKLTNGSHIEVNETGTSIYYKPGLLAGGTIDHECNSQRAIGYYLEGVVMLAPFCKKPLRLTMRGVTNDTFDPSVDVIKMVTIPLLKRFVVDDKGLDIKISKRGSPPDGGGQIFFSCPVRKTLRPLQFTDPGKIKRIRGLAYATRVSPSMVNRVVDATRGVLNQFVSDIYIYTDHCRGQQAGKSSGFGLSLVAETTKGAVLGAQCSSNLPGQGEPTIAEDLGKKTAHMLLDEIYKGGSVDSRHQSLVLLFMAMGQPDVSKVLTGPLTPYTIQFLRYLKDFTGVMFKIQTQEKDSEDDSRTGGPTKILLSCVGMGFTNINKSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I310</accession>
    <name>A0A6P8I310_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/arginine-rich splicing factor RS2Z33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562218.1">
        <property type="nucleotide sequence ID" value="XM_031706358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I310"/>
    <dbReference type="GeneID" id="116298017"/>
    <dbReference type="KEGG" id="aten:116298017"/>
    <dbReference type="InParanoid" id="A0A6P8I310"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562218.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21350" checksum="1568633819644A08" modified="2020-12-02" version="1">MLKIKMARGGTELFVGRLSKETKQRDLENVFYLYGKLSRCDIKYGRERAYGFIEYEDPRDAEEALRRENNRKLFGSRIVVEYVKGKERGGPAGDECFKCGRLGHWASSCTVSRDDTDGFRGSGRHARPSPAILLKRPPPSRYRSRSRSPRRFPNPPPRRRRSLSPPRRPRPPPISRSRDRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3W3</accession>
    <name>A0A6P8I3W3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 61-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116297972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031562151.1">
        <property type="nucleotide sequence ID" value="XM_031706291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3W3"/>
    <dbReference type="FunCoup" id="A0A6P8I3W3">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="GeneID" id="116297972"/>
    <dbReference type="KEGG" id="aten:116297972"/>
    <dbReference type="InParanoid" id="A0A6P8I3W3"/>
    <dbReference type="OrthoDB" id="382863at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056299">
        <property type="entry name" value="CFAP61_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032151">
        <property type="entry name" value="CFAP61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23150">
        <property type="entry name" value="CFAP61_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16092">
        <property type="entry name" value="CFAP61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 61 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP61 dimerisation" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031562151.1"/>
        </source>
    </evidence>
    <sequence length="1205" mass="137411" checksum="3AFF1CD2892B27C0" modified="2020-12-02" version="1">MSGAEVIQARRTESLDAPEILKLVSGGTEKLFGRVNVVNIIEKANLAVTLVNAKNDVIAFAAFFDYPNIPSINQAKWEEWLKEKYDCTKANALNSLFLNFFVAKPDFALGCASEIIRTVFNAVPFLHYLFLVMPRGADCGPGLFEIFNSMRYNPDFKGNLNFEVKICHRHEHCPKLHIRHARVEDHDDLMPTFNRQNDVLTSMYGNFFLAEMIEAQDEDNRCLVADVDGTAVGFMSVCSQVDCQILNRCFDLGPFNGLKKLVDGDDTGSMNEEMVKEEKVVKDIPEQKEERKSSTDSGKSSKETKDDEILEEEESQSFVPKLSDEHMRQGYDSESDSDSARKTSVYQGIESAFCIQLFCIDEKYEMRSLDFLPAAFAQFPDRDYCILTMPHLVSEFPLLQSFTRVTPKRHSTLSQELYVYHRWGLIESFSVKPCTTSDTDGIKNVVKSLKGSNRIMTDIEQYIASRRDHDGTQLQAFVAESMGQIVGVAILRREEDIEYIRSHYSIEDFVYFNHHQREEHAHLHHFVLNPIFQQYSKHFLKEVLRLSHKSCLYYPIFPRYSTLEGIKPHSTVTALNDLVTIKARRQIIYPVEQLGGNAPSDRILQPKEPFALNHLNRKLTLEPKVAINARIVVVGASDVGISFLETFVFCPHLRFNNLTLITPQGLPGQSAPDPQVNQFLPSSLCFTDDDHAHMSLRTWINVVKEKMTRIDRTNKIVYVTNDHKVPYDYLVLCTGQQFQIPVPSGADISTLVTTSEVERPRDTVYRGTLPGNVFAINSLQDSAHIVKWLKDQFLASDGKAVVYGWAMEAYTTIQGLLSLGVPASRIVMVQPPPPIPSCFNNLDIDEAIENSLKTLGVEIHIGFTLAQWNDSNLDGPLTCATFTSDNKPLRVECQAFFCFQEKRVDYQAFKAINDSCLVFDGKLVVNANFHTNDPFIRAAGPLTKYQRRYHAESWTHANYNSKEIGSELAHSMLVLFDPTLEGFSPEPVSMEDDQLVPIYKQAKMYSALLPGGYHYLHVGKPGLNLPLDSLMVQPEYGRELVTGSAKHDESSPGYFRLHVNQYRSIETITCLSKQPIDTSNLLCLYGLHERYLNNLLQRFDEDLITNFYSFFRESWCLAIFHDRFNDFREEVRELLVSKPEQDAHSLEEKVRKMIDEDLVLTKEQRRNLRDAYIASPVRKAIELRQLSFLSYNSYHLPMYVKQGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4J9</accession>
    <name>A0A6P8I4J9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559837.1">
        <property type="nucleotide sequence ID" value="XM_031703977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4J9"/>
    <dbReference type="FunCoup" id="A0A6P8I4J9">
        <property type="interactions" value="2775"/>
    </dbReference>
    <dbReference type="GeneID" id="116296011"/>
    <dbReference type="KEGG" id="aten:116296011"/>
    <dbReference type="InParanoid" id="A0A6P8I4J9"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000025">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031559837.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23862" checksum="D94F196D900DEBF5" modified="2020-12-02" version="1">MADSLSSKEKDFASKDAENSLKRKREPDQEGETPSIKKELEGMESPPAKIAAKTADISSSAQITTERRTSSDNKSKGTELSTPSTSENPPQKQETDGQGNEKDGGVEKMQLLVSSFSEEQLNRYEMYRRAAFPKAAIKRLMQSVTGGSSIPPNVVIAMAGIAKVFVGEVVEEACDTKEQWGNKGPLQPKHLREAVRRMKKKGLVPSIRYKKQLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4M4</accession>
    <name>A0A6P8I4M4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559857.1">
        <property type="nucleotide sequence ID" value="XM_031703997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I4M4"/>
    <dbReference type="GeneID" id="116296035"/>
    <dbReference type="KEGG" id="aten:116296035"/>
    <dbReference type="InParanoid" id="A0A6P8I4M4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF335">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028463156" evidence="2">
        <location>
            <begin position="24"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="196"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031559857.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48060" checksum="7E69D24B322D4D22" modified="2020-12-02" version="1">MTSTKRWILPVAWLFSMASFGTCFSDCTSPLGMTSRAIKDHQITASSTFSDFTKPQEGRLRNQRIPGQFSTFAGWCADDNDASPYLQIDFQQETVVRELATQGLEEPSGNWVTEYALNYSCDGATWTAYKDEGDDKQKVFKANTDDSTIVKVHLKLPVIARMIRFRPLKKRNHGMACMRVEMYGCKSNPDKQFSDCSVAVGVENGQIANAQMTSSSHSQSHFPYYGRLNNKNKVVDGNVSWGAWCTNEVRNKQYLQVDLGNTRSISGVAIQGYAKGGWVTKFMLQYSLNLKEWNLYKDFNSSKNMVFDGSWDAETIIKHDLNVNVQTRYVRFIPTAWKTSGNICMRVEVYQCIYYKGCPRLPTTIQPTGTITSSLSNTGISPTGEPTLQSTQDKNNNVRNSNSLGSIIQVEFLAFCFCFLCCYFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I559</accession>
    <name>A0A6P8I559_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc metalloproteinase-disintegrin-like atrase-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116298665</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563048.1">
        <property type="nucleotide sequence ID" value="XM_031707188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I559"/>
    <dbReference type="FunCoup" id="A0A6P8I559">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116298665"/>
    <dbReference type="InParanoid" id="A0A6P8I559"/>
    <dbReference type="OrthoDB" id="5985446at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027553969" evidence="12">
        <location>
            <begin position="24"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="15">
        <location>
            <begin position="215"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="14">
        <location>
            <begin position="420"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="735"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="17">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031563048.1"/>
        </source>
    </evidence>
    <sequence length="924" mass="102342" checksum="84FCF02263768D4C" modified="2020-12-02" version="1">MRKAGLFLIVFVVLLALVLRIAGFRSDRQHFPDEFLENYEVVHLKRVLDDGRYRRSADPLSTVYKNGHQEEISFSVEGFGRRFVLQLSRNRGLLPKGSRHSFVSSKGILTSQPFKSIDNCYYHGTIKGLPKSSVAISTCGGIEGLIFDGNERFYIQPSEEIRNTTHANPHIMFKMSDLKLPKVKCGHDHEHDVMELLHTSKIKTRKRRNIDSETKYIELVLVNDNSQYKYYQENTTQRALKIVNYVDSFYRALKVRVALIEMITWKDKDEILVGNNSNKALANFVKWRNVVLMKNRTFYHDNTQLLTHMQFERQTVGKAHVLAICTTRSAGVVRDHSSNAAATAATLAHEMGHNLGLDHDDRKECKCPAKKKDQVCIMSGVARFEPATDWSSCSVKEFQKMLDKGLDSCLFNEPKELYGDPVCGNGFKEEGEECDCGNYTECEKYTDNCCDPRTCKLLSHVECDEGPCCEKCKFKSSKVLCRKKVTECDLPEFCSGSSSLCPSNKYVYNGKPCDGGKGFCYGGICPTHDSQCEVLWGKDVKSGPKLCYTANERGNHLGSCKLEDEVYTACKKKDIFCGTLHCTNTKTDLPVIGSDRKVYKYTYKTEKGPIECRSASLDLGRDVPDPGMTKEGTKCGDEKVCLGQECVNVTQLYLSNPKCPGDCSSHGVCNNEGDCFCDDGWGGRDCSKNIGLAGQSKLAGYVILVFLCIALVAGCVGGFIFRDQLKTKWQERQQSRQKRYRSVEGKPTLSPSSKTASETLTDGREVPSVTIAPKPPPPPASRPVASRQPGKIELPSWPAENRHDELGAPVPRRAPPGIPKQSSLNRASSPPIGSYDSKPAAGARPGSYAGVLDTTPVNKPPQRPSPLAGLSQGSTNRPLLPSEIKKSQETIGGVGPRPAQPHKPARMPPPLPSKPPATGFTNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I701</accession>
    <name>A0A6P8I701_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116296851</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116296851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031560817.1">
        <property type="nucleotide sequence ID" value="XM_031704957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296851"/>
    <dbReference type="KEGG" id="aten:116296851"/>
    <dbReference type="InParanoid" id="A0A6P8I701"/>
    <dbReference type="OrthoDB" id="10397192at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031560817.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17429" checksum="51414B3182A0C0B2" modified="2020-12-02" version="1">MPPKRSLTNLNEEVPERNPLSSTPQSTSTVTLSQEYRRELVDEVVRAVLAATQQTAISQSPAATTSQPALPLQSTAQDTPGTSNVLVPNFVNTFSLASVNTTSTASIVTLPIPQARSLGAVGGPPSSXTTVLSGPSRRRRPSQRQQFFSPLLLDLVLLRSRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7U2</accession>
    <name>A0A6P8I7U2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein CLEC16A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563331.1">
        <property type="nucleotide sequence ID" value="XM_031707471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7U2"/>
    <dbReference type="GeneID" id="116298891"/>
    <dbReference type="KEGG" id="aten:116298891"/>
    <dbReference type="InParanoid" id="A0A6P8I7U2"/>
    <dbReference type="OrthoDB" id="5981281at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="4">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031563331.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="63675" checksum="4BA631147FF2341F" modified="2020-12-02" version="1">MFQRQKNWLSDVLWKPKKAHSLEQLRYLHYVLNKNSVINETNRGLLVETLRSIAEILIWGDQNDSRVFDFFLEKNMLIYFHKMMNQKSSNQICVQLLQTLSIMFENIRNQTSLYYLLSNNHVNSIIIHKFDFSDEEVLAYYISFLKTLSLKLNTQTIHFFFNERKNDFPLYTEALKFFNHSESMVRIAVRTLTLNVYRVGDQNMLHFIRDKTADPYFWNLVWFIGSHAIDLDNCAKKEADHLRCDHLKHLVADHLDHLHYINDILCLDIHDLSTILTEHLLDRLLIPLYVYSLVKEKPDIDLVKPRINALLSLYLLSQILLIMSYPPLVSSLVDIILNGDEVDPGATPEASPLPLKKAVSKASSSASIRTFQCPEQTLEESLVAYGVNTEGYMFLGKSSMISLSRDRPKTVHVANSKFYIKEKRKMEGGFLEEKIDDPISTVATKLSGITVPVTDTPLGETNSEVDSLGSVTPTQPHTTDERPVKGQNKELFTKASRIPVKSFVRRSKDFEPDRLFFDTLRSSLECTENDGEALFALCLIYAAIQNKGVDKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I828</accession>
    <name>A0A6P8I828_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC116299638</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6 7 8 9 10 11 12 13 14" type="primary">LOC116299638</name>
    </gene>
    <organism evidence="2 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564186.1">
        <property type="nucleotide sequence ID" value="XM_031708326.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564187.1">
        <property type="nucleotide sequence ID" value="XM_031708327.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564188.1">
        <property type="nucleotide sequence ID" value="XM_031708328.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564189.1">
        <property type="nucleotide sequence ID" value="XM_031708329.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564190.1">
        <property type="nucleotide sequence ID" value="XM_031708330.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564191.1">
        <property type="nucleotide sequence ID" value="XM_031708331.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564193.1">
        <property type="nucleotide sequence ID" value="XM_031708333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564194.1">
        <property type="nucleotide sequence ID" value="XM_031708334.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564195.1">
        <property type="nucleotide sequence ID" value="XM_031708335.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564196.1">
        <property type="nucleotide sequence ID" value="XM_031708336.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564197.1">
        <property type="nucleotide sequence ID" value="XM_031708337.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031564198.1">
        <property type="nucleotide sequence ID" value="XM_031708338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I828"/>
    <dbReference type="GeneID" id="116299638"/>
    <dbReference type="KEGG" id="aten:116299638"/>
    <dbReference type="OrthoDB" id="5961311at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031564188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031564189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031564190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031564191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031564193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031564194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031564195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031564196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031564197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031564198.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25128" checksum="BD66FDE797B9C5CF" modified="2020-12-02" version="1">MEDTSERKFPPRSKFNDEEATAVLRLIIEQEKLLKNANTRPLLNISANRLQRLPPLNAKRSESLDENELENVRTRKPSGHREPGSEIFLKPTLLKGKDSRSLSDNVSLPGKPRRVPDIYSTPKIVKPHRDRERPKGSYGRNNALRKDINNELTPLENHSDERQLETEVQRSESNGCHKDATETEDNTFSPIHNGYISDHGLYERPNCPAPAQYSPPSYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8H5</accession>
    <name>A0A6P8I8H5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="18">1.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116300192</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50820"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:17347"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:50822"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5alpha-pregnane-3,20-dione + NADP(+) = progesterone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17026"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:21954"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54384"/>
            <dbReference type="ChEBI" id="CHEBI:13601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:47909"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>androst-4-ene-3,17-dione + NADPH + H(+) = 5alpha-androstan-3,17-dione + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:50816"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16422"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:50817"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.22" evidence="18"/>
    <dbReference type="RefSeq" id="XP_031564859.1">
        <property type="nucleotide sequence ID" value="XM_031708999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8H5"/>
    <dbReference type="FunCoup" id="A0A6P8I8H5">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="GeneID" id="116300192"/>
    <dbReference type="KEGG" id="aten:116300192"/>
    <dbReference type="InParanoid" id="A0A6P8I8H5"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047751">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006702">
        <property type="term" value="P:androgen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000002">
        <property type="entry name" value="Steroid 5 alpha-reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016636">
        <property type="entry name" value="3-oxo-5-alpha-steroid_4-DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF57">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015596">
        <property type="entry name" value="5_alpha-SR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="19">
        <location>
            <begin position="119"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR015596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031564859.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31067" checksum="2D80783610D15BE3" modified="2020-12-02" version="1">MADVLGFFRSYSEQEIIFFLCTLLNFFGLLSALLLQFMYAEYGRYFSSNSTTKWGFGIHPRIAWFSQELPMFTLPLIFLLYAKDGNLGLTPNTVLICMLVSHYFRRVFIYSFQLKGGKPTPFLIWFFALTYTLINGYVQGRHLAMFAEYNQSWFTDPRFIVGVLLFFTGMMLNIQADNILTNLRKPGETGYKIPRGGLFEYVSGANFFSEILEWSGFAVACWSYPAFTYAFFTLCNIGPRACQHHRFYLEKFEDYPKTRKALIPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9D4</accession>
    <name>A0A6P8I9D4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Testican-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116297611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561732.1">
        <property type="nucleotide sequence ID" value="XM_031705872.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I9D4">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="GeneID" id="116297611"/>
    <dbReference type="KEGG" id="aten:116297611"/>
    <dbReference type="InParanoid" id="A0A6P8I9D4"/>
    <dbReference type="OrthoDB" id="8875634at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="4" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027759290" evidence="10">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="12">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="11">
        <location>
            <begin position="329"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031561732.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="48047" checksum="7FFA900815A6E872" modified="2020-12-02" version="1">MKVLLLLAFVVLVTAFAEAKPKWKKVLQERKQRITEEKHRQHCSEIECPKYSACKIKKTGKSIKVICVKCKPCPEXXESRPVCGTDGNQYESRCDLNYQACMHNKIGLLRVKCQSTCAECSGNRVKEHMIDSNRLPKADTRDSDGYLTEGQPEEEEEEMEETENIKSSKRYKKWNQWKKYKHDFQKYKMQVMQMAGMQLTDENNCSQYENATLGSRLLDWFHVLRSEYIKHNLKKAGKPVVHPIIPQMELRQAHEPYPCGHHHDECREPINFMFHYLDMNDDHVLGQEELLELKQIPYEHCITQFLNSCDKTKDEQLSVQEFCECFPVEPPCLAKLKDVPTIVQRGQPIPLPGHFLPRCDXDGFFLPMQCHMKATAEFCWCVDRNGGKIEGTYKKGKTDCDDNTINPRDNEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I9L6</accession>
    <name>A0A6P8I9L6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neurofilament heavy polypeptide-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116297695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561832.1">
        <property type="nucleotide sequence ID" value="XM_031705972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I9L6"/>
    <dbReference type="KEGG" id="aten:116297695"/>
    <dbReference type="InParanoid" id="A0A6P8I9L6"/>
    <dbReference type="OrthoDB" id="5981129at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027680295" evidence="4">
        <location>
            <begin position="22"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="5">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="888"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="7">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031561832.1"/>
        </source>
    </evidence>
    <sequence length="921" mass="102403" checksum="801EDC5D0B5C409B" modified="2020-12-02" version="1">MPVTKSVIFVVVFAVVSSINASKVDKKSGIYAHHHEKKCEDYKAVASKCHMWKDLGFCFKHRKEMEFVCSKTCKFCDPGESHWTYTSKPDENAETKTIIETPNKPSPVVEVMGKKKALYLSSNDIAGMLQTLSSQNYDVTEKPTPKPKELAVIQGRIQKVEPVVIKTDAKGEMKIKPTISVGGKMQTEPKAAEKEESGGKDEGKNDAKAEDKKKEGQNRENSFENKLLGLMSQVIRGGSSEREKKPKDNASEIKKAECVNIPEIMKILQNLKEKMKKDKENPVKEKQATEQKPPNVASAEQKVNTTGNQVLTAKNKALLAAMKLFQAIGPASKGNHSSLMEQLTAAAEEASVALNLLNKTGAVDKLKEANVPSKVGNVMYNVKLLQEELNKANKNHSNVVTSTPVLETNATANSTKMAVVNVSSSNPQLSEFILRLQDSITNPQGNVSALSSSVSERGGVAIRKEEGKPTLSEIIPFNIKVDDADSDATGNFKSETPTEGTTKPDTKVTYQSDEQKIMEILDGLDQDDKPKTVQDKGNSAKDIVMQIREAYDDLGEIVNGAEIQEGLKKKKKKEDEDNEEETEESSEEKKKKDEKKDEKKDEKEKFFDPNAKPKPKKKKPLTKEQHLVLVVSLIKKAGHYLEMIGAKRVKMAGKSQDPSDEDASMRSSHNSYNQGDWKMLATRLARQLGLVLKKMAEKDEKYKAERNRLQSVLAALAQTELSTKHTYEDTSEEGDEEGDDDYNQDEDRSKIIHNMATKLLNFSKTISAVQKSSRGKPVRKKKKVLHNLVSRYRSLVSKILSNWKKLKGKKKSGIPRRTGKRGEIVRGAGNHTLKAVHGKPVVAKVNQTEAKAKQKTQDTHKKEKTTVIKPTQSVSLHATVQTKKTKKKAEEKKEIGKEATKKETITPDSDDEQDVIEIVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IB47</accession>
    <name>A0A6P8IB47_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116297817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_031561980.1">
        <property type="nucleotide sequence ID" value="XM_031706120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IB47"/>
    <dbReference type="FunCoup" id="A0A6P8IB47">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="GeneID" id="116297817"/>
    <dbReference type="KEGG" id="aten:116297817"/>
    <dbReference type="InParanoid" id="A0A6P8IB47"/>
    <dbReference type="OrthoDB" id="5988573at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561980.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43745" checksum="39330966BDCD75B8" modified="2020-12-02" version="1">MTYYYIRRRFVGLFVSRRIRTVYKVVIFLVFLISLSAFYLSVVSPEIPQNVFFLKLRGNKSRFIDLKWNCSCEFGSGSTPSNKISTSPGSSKDCLNDQSRQADTDFSTVGWTNFSLIMPRVEPNISCEERKLFMVVVVNSATDDRHRILRMSIRKTWGNLTQGKGNQKWRIYFALGMSSSYAMNLKNVQEALQYNDIIIGNFSDTYKNIVIKTFMSHFWVYSQFDCMYVMKTDDDVYVRVSRLSKWLEKQGFPNPFYGGFLSENLLVVRDPKSPWFVSKEDFNETRWPPFSHGAFQVVSTAILPRCFNYTQSVKRPLTTDNAYFGVMARDLGVNATQIPGFSLNPPKSDFEVMIATAFGHALDSSAMFKYHARYHNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE67</accession>
    <name>A0A6P8IE67_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116300234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116300234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564922.1">
        <property type="nucleotide sequence ID" value="XM_031709062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300234"/>
    <dbReference type="KEGG" id="aten:116300234"/>
    <dbReference type="InParanoid" id="A0A6P8IE67"/>
    <dbReference type="OrthoDB" id="6111702at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031564922.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16195" checksum="58875E9F2422632B" modified="2020-12-02" version="1">MPVIDLKGKITAIVDVVKDNISGELDKEADEETGFNXCSSDNPSCDAWGNKNWKSIILTALKRKGDFVKLILQSMYPAGSENISLESPNRKKFFHEIKVGETFYWPENQLLVNNLQSTNKHVATTTITSKHRPSLLTNTVPPPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF06</accession>
    <name>A0A6P8IF06_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-beta-glucosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116300351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031565070.1">
        <property type="nucleotide sequence ID" value="XM_031709210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300351"/>
    <dbReference type="KEGG" id="aten:116300351"/>
    <dbReference type="InParanoid" id="A0A6P8IF06"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02847">
        <property type="entry name" value="E_set_Chitobiase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06569">
        <property type="entry name" value="GH20_Sm-chitobiase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004866">
        <property type="entry name" value="CHB/HEX_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004867">
        <property type="entry name" value="CHB_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF57">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03173">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03174">
        <property type="entry name" value="CHB_HEX_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM01081">
        <property type="entry name" value="CHB_HEX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="Carbohydrate-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028297960" description="beta-N-acetylhexosaminidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="domain" description="Chitobiase/beta-hexosaminidases N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Chitobiase/beta-hexosaminidases N-terminal" evidence="10">
        <location>
            <begin position="916"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031565070.1"/>
        </source>
    </evidence>
    <sequence length="1791" mass="203113" checksum="2490E38A3B28C1CF" modified="2020-12-02" version="1">MASVMLIFLILGVCLPVLNAQVSQSTLDYIAGNLGLRYDILDNMQDTWKTYLIELTLTNEGSQAISLGNWAIYFCHIRVIEPEHTKHNPNGYVLPGYALKITHINGCQHKLEPTPEFRALVAGEVRKIRFKSEFWAVAKTDVMPNFYVAADGLQARTITSTSGESLDFVGDFTTPKQWKRYDADKYNPYSPQVRFTINDIKDMKRPGLPVIPSPSEVTGFEDSQRLNLMTGDWSLVAESGLSREKKFLATALGLNINYNINTFRQIHLKLGDVQIAGKPSSSNEAYSLNVEVLLERITITGKTPVAVFWGIQSLLSLGHSGYVPQISIRDAPRYEYRGMEIDLGRNFMPKSEILKTIDAMAMYKLNKLHLHLTDDEGWRLEIPGLPELTTIGSRRCHDPQETQCVDSQLGSGPGTGNAGTGFYTVDAYKEILRYANDRHVEIIPEFDMPGHGHAAIKAMQARYQKYLAMGDSYKANQYLLSDAQDTSKYLSVQFFTDNAINPCLESTYEFFEHIVFQVRNMHLGIQPLKIFHFGGDEVAKGAWTKSPACAKMSAQLGLNFTSPNIVKDLKEIFVRRVANIAHKYCLDLGAWEDGVLGVKDTPYDRSYLKNRHVYAYAWDNVWEWFQGDRAYKLANAGYKVVMTQATHLYFDHPYEPDPEERGYYWAPRFIDTRKTFGFMPDDLYANADFTRMGDPIIDLCNNMYKGKCIPLSKPENVAGMAGALWSETVRTPSQLQSMIYPRLLALAERAWHVGCWESEKDVAMRKQHQKLDWELFANSLGHKELMRLDKLNIDYHIPVPGARVVNGVLETNVALPGLVVQYSTDNGSTWSDVTSGLRLTGKVVLATRSADRRRQSRRIELQIFIRALSGCYVDLDHLSMRLNTLTFECLLIYIVGPAKYSSLVRLDQYLLNRVVSSLAVRYDVLDNLQTTLNDNPKTYRAQITLTNKGRDVIPKGDWGLYFCHIRMIEEEHTAHAPSGYRIPGDHGFKVTHINGCLFKFSPTEDFKDLDVKNSIRIQFNASFWCVSRTDVMPNWYIAAEGLEARTITSTAGEGLGFVGLFDTPRKWKRYPSDKYNPYTSEQRYEMSGVSDMGRPGNVVLPTPLNISRYNVSRTADVRTGDWIIVAPIELEKEARFLAGKLGINEVTTQGSHRVFRLIQLKLDDVKLGGNFSSNQEAYELNVDAGKSIITILGVTASGVFWGVQSLLSITREGRVPHIHIVDAPRYEFRGMHIDVARNFFDKENIFKLINVMAMYKMNKLHLHLTDDEGWRLEIPGLPELTKVGGRRCHDPTEKTCIASQLGSGAFTGNTGSGFFTTNDYRDILQYAEDRHVQIIPEFDMPGHAHAAIKSMNARMENLTKLGQYDEAKKYLLSDPNDQSKYLSAQLFKDNAISPCVNSTYEFIETLVKAIKALHSGIQPLQIFHFGGDEVPKGAWTGSPSCKDLAKELGISLTDPSAVKHLMGYFVQRVSNITKTHGLDLAAWEDGLLGADEQPYKRSLVMNRNVFANTWDNVWEWNKATRPYKLANAGYKVVMTQATHLFFDHPYEPDPEERGYYWAPRFTDTRKTFGFMPDNLYANADFKQNGEKITNVCETIYEGKCEQLYKPENIVGMSGALWTETIRTSEELDSMLFPRSLALAERAWHKADWENIQDDVRRERMKTRDWEFFVNTLGYKELGRLDKLNVAYRIPPPGARLVSDQLHTNVLVPGLTIQYTRDEGKTWSDVQEGIRVTDGIKIATRSADRRRTSRLIDVSGRKVTTTNSSPRLDKMXSTTIILWLLANLLVLRIHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFL2</accession>
    <name>A0A6P8IFL2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Doublecortin domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116300746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031565529.1">
        <property type="nucleotide sequence ID" value="XM_031709669.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IFL2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300746"/>
    <dbReference type="KEGG" id="aten:116300746"/>
    <dbReference type="InParanoid" id="A0A6P8IFL2"/>
    <dbReference type="OrthoDB" id="9999986at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17156">
        <property type="entry name" value="DCX1_DCDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043188">
        <property type="entry name" value="DCDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056415">
        <property type="entry name" value="DCX2_DCDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057424">
        <property type="entry name" value="Ubiquitin_DCDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302:SF3">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24478">
        <property type="entry name" value="DCX2_DCDC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25510">
        <property type="entry name" value="Ubiquitin_DCDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="289"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="485"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="1811"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1625"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1724"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1904"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1582"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1934"/>
            <end position="1945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031565529.1"/>
        </source>
    </evidence>
    <sequence length="1945" mass="218580" checksum="D1A61BD32666A309" modified="2020-12-02" version="1">MASQSKQRPLTAMQRGMSDIISYEDILIAQYMNQIEKSPPTRKQTKDVPVSPYAIATQTGEISKSKRPKSAVALHQKRKDFESSRALASQGRVPLMAWDEGELAPRTTSKKRPTSASSIRSRSSVLSGTGSAYSRSSSKSLNSKASSTAGSSSIKRNKPLYKKKPKVICIRAFQNGNRENFARVTAPDLLQLLDNCTLKLGLVSAARKLFFSDGTLITDSRLIEKDDDVYVSCGEAFKDPYSTLKEKEELRRSACWTLTGIVLPENKSRGKTKTTLSKRMQTLVESQKRRILVFRNGESAEGVEIVAARFNEFLDDCTAKLKLESGARCLFDWEGHEIKSFRDVPVLERILQPSTTTVLGPLWVTRGGESFSPKGAYNFLLTVLSNTKERIRYSKLFNDQLNMQSNCSPDLQSKEVMSMTDEEIQKEIQQVEEHITELLSVVPTLKKQLKRLQEGVDIEGGMETHKYQHISEISPDSRLLGKQGLRFKVFENGRNDGEVIVYFNLAEAEKGIQGDKSQLMHRFLDTCTTSRRVGDGTGGPAGRQIARRVFIKDGKEVTNVHDLEYDQEIWLSYGEDFKPLNVMALQLTLDKASCMSLWDEMEIVQREAVMDEEKGRDRPTAWRAVTGFPPGNKRQLINLDMPGPKRLEYAQGLQKSRVDEKGCFLQYREKKNLVLYPEVTIEVKKKKGAKDIWPPDAQEWAITQGGIIFSKSMPQLSLAKSEHAVQVTVFDKPVGGFSVQLAKRSTNDLNQQWGFSPTGQIYSLAKPSFFLTYVAGHEVTMVTAKDCTSLEQAASESQPQKEEEDLGNGLANLQFLDTNESNGENGNHKDEKSEDANNVSNQEIETILPGLADLETEYGGKTNVIVLLPKLSGKAGLQRWALKQEDLGSIGQWKHTTVANPEWNKKALSWPVTKDGNWNTEYSWPMEGFLLPFAPPVKKPSDKKSALPGSAVRLRVMKNGDSDQTRVAVVVGPDLTNMWHDVSDANRSFKTKRRSLGKPANNSSVGVYESDACHPLDCKRIEIELFLDQCTQALGLPFAGRKLFDEEGREITCISDLTRDQLVYVSCGEKWIDPQMSYSEQQRRALLMNLASDIARIRQYCVLRDPTDLVLDVDGPILPGSRIVVENCVLSSLEREKLIKKLNDDNADEVEDEDAISSAALLSYAITAHERAHQRADERLKSLRWSWENDKTSKGDQDLEGQDEGDFTNEITFSDPVLQKKFVRQAIKTGDAKQVSDPSIRQRWHYRDGFIHLKNNSLLVLGLADGINEGTASNEVVLCKKKLEDPCQRWIISEDGTISLRSNVQFVLTVTTPPLGNDPFSYDKALDHGYLGSAVIVATRKSCENGNCHQLWSFDRFTGFIEAFASDTANKEITAANKSNVCTYAILGQREIYQPGYAYMPGTSREKRLCEACGKASRGKNKLQRLKDSRRFACNTGTNDENGNNGKLSGCFKCLSSKVDLTTLEAESTLELWEYQLDRLRNEGNVRTITKELNVAKSVAAVRILAHRNGEGSRGQGELVIGSSIHSLLDQSTTRLCLMQAARRLYTVRGELITDIHQLFRPYNASMMRSLQESEEIVLAEGDEKKTKKKESPPSIPNGDAVDYIEAENKRYYISDSSKEVQKLDLSGAQDKVDDEDNESGNDTYRLGKGRKRRSLPTVMQDPSGFPRWDTRWPIDVWVSCGEPFIPLEEADKQYLLSMKHREERTWLQAYLDIEKHVLRQMQGRRITRFSPPQSPSNEPTRKEEHKEETINELKMHLLDVKSRQKNEELALSKPAKESTQRLYSTPKTVRIEVFQNGESIERAVIVYGASIREVLDNSTSRLGLSSAARRIFRLDGREILEFADIRRGETFCVSCGDNFIRARDRRHQMELKATWSRMVRCPGGYVLTESTAANVTYEARSSNPQLALPAPPSPATSAFKGQEHPVGQVSVHTLHRSSKPLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IG39</accession>
    <name>A0A6P8IG39_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">General transcription and DNA repair factor IIH helicase/translocase subunit XPB</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA 3'-5' helicase/translocase XPB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116300879</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="RefSeq" id="XP_031565707.1">
        <property type="nucleotide sequence ID" value="XM_031709847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IG39"/>
    <dbReference type="FunCoup" id="A0A6P8IG39">
        <property type="interactions" value="2513"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116300879"/>
    <dbReference type="InParanoid" id="A0A6P8IG39"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="344"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="559"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="21">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031565707.1"/>
        </source>
    </evidence>
    <sequence length="799" mass="91323" checksum="B2B25F5F34293F12" modified="2020-12-02" version="1">MKPQKRKRDEASNSKKSKKGKTQVEEEEYEFEDEEESLTEEGECIPKSSGAALKSENQEDEFGARDYRQQIELKPDHSSRPLWVAPDGHIFLESFSPVYKHAHDFLIAISEPVCRPEHIHEYRLTAYSLYAAVSVGLQTSDIIEYLRRLSKTTIPDGIEKFIKLCTLSYGKVKLVLKRNQYFVESNHPEVLQTLLRDEVIQSCRIIPEEGDAPEVSEILKSTDKGRSAIKFNSKQKENNTADSSKAQDSSQEPGEQEKTAIPSDITDYIDKIDQDEEDEEESQIFSFEIRQEQIEILQRRCIDLDYPLLAEYDFKNDTVNADLNMDLKPTTVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKTLVGVTAACTVRKPCLILCTSGVAVEQWRSQFKLWSTVDSRIICCFTSDAKDKPKDCGIAISTYSMVSHTGKRSWEAEQVMSFLQAQEWGLMILDEVHTIPAKQFRRVLTVVQAHCKLGLTATLVREDDKIQDLNFLIGPKLYEANWMELQNNGFIARVQCAEVWCPMTPEFYSEYLAIRTRKRKLLYVMNPNKFRSCEFLIRYHERRNDKVIVFSDNVFALKNYAVKLGKPFIYGPTSQAERINILQNFQHNPLVNTIFISKVGDNSFDLPEANVLIQVSSHGGSRRQEAQRLGRILRAKKDMAAEEYNAFFYTLVSTDTEEMYYSSKRQRFLVNQGYSFKVITSLAGMDEENLNLSTKREQQELLQKVLAASDADAEEEKNAGDPNQKSSGVIRRAGSMASMSGADDMMYLEYRSSSRSSSNLARHPLFKRFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGS5</accession>
    <name>A0A6P8IGS5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">THAP domain-containing protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116301070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565929.1">
        <property type="nucleotide sequence ID" value="XM_031710069.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301070"/>
    <dbReference type="KEGG" id="aten:116301070"/>
    <dbReference type="InParanoid" id="A0A6P8IGS5"/>
    <dbReference type="OrthoDB" id="5971057at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031565929.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="23671" checksum="0F696CF4DBEA0079" modified="2020-12-02" version="1">MPHKSNCCVPGCLNSFRNAPELHYYRIPKDEEQRKXYERILRNETLKIESQATRVCSAHFEGGEKLSRNHFPTIFPWTKQTHKRREISRHPVVDKSQKKKKQRVESETNEQTIENPDFHHGVEVNNQDIQQATETLLSGQDIDRLLEIEKQYLAIKEENEKLRSENKDIDRLLEIEKQFSAVKEENKDLKKQLAELKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IH17</accession>
    <name>A0A6P8IH17_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116301251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566147.1">
        <property type="nucleotide sequence ID" value="XM_031710287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IH17"/>
    <dbReference type="GeneID" id="116301251"/>
    <dbReference type="KEGG" id="aten:116301251"/>
    <dbReference type="InParanoid" id="A0A6P8IH17"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="245"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031566147.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="53916" checksum="4C82015B0FC05CF2" modified="2020-12-02" version="1">MMLRVMSRRGASVLSRVRVIRCVSTTTPTLVQEADKSNENKHFRFTSIDAFMDFVSKNNPGESEFHQAVHEVVTSIWDVLSENPYYNQHNILERIVEPERVVIFRVPWRDDKGNINVNKGYRVEFNSTIGPFKGGLRFHPSVNLGILKFLGFEQVFKNSLTTLPLGGGKGGSDFDPKGKSDNEVMNFCQSFMTELQRHIGPNTDVPAGDIGVGGREIGYMFGQYKRIRNEFTGVLTGKAHGWGGSLLRPEATGYGLVYFTAEMLATKGESLKGKTVTVSGSGNVAQFATEKVKQMGGRVVTLSDSSGTVYDPDGIDKEKLAYVSELKNVKRGRISEYALKYGVKFYEGKRPWFIKCDIALPCATQNEVDEEDAQTLVDNGCTCVAEGANMPTLPKAIEIFQKAKILYGPGKASNAGGVAVSGLEMSQNSLRSAWTREGVDERLHDIMENIHSTCVKFGTSKDGSYVDYVRGANIGGFIKVAQSMVEQGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHF4</accession>
    <name>A0A6P8IHF4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116301305</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566201.1">
        <property type="nucleotide sequence ID" value="XM_031710341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHF4"/>
    <dbReference type="FunCoup" id="A0A6P8IHF4">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="GeneID" id="116301305"/>
    <dbReference type="KEGG" id="aten:116301305"/>
    <dbReference type="InParanoid" id="A0A6P8IHF4"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028444837" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="27"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="197"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="338"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031566201.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="40718" checksum="46E3D0513E643E3E" modified="2020-12-02" version="1">MNSKESWKICLFVVFVLISYSAFSEGWKDDRVKLNDVNVLTLRQGHMSNGRRSAPVPQMKCVGGSAGCSAFVPKVVQCYNRGSDGYDVQWECKADMDNGYRFGEISVSCEGYDYPEDSYILKGSCGLEYTIDHVGGNSGNAYHHSSSYPHSNQHGNYGYKQHRNRVFPCSISTLIMWGIIAFIVYYIYSTCSANQHMTDSTQDTSQPSTYGTAPPPYTPPPPGFRPEYTQDQRAHTTNTSSSSSSSSSGLGGFWSGFGTGGLAGYLFGSSRGHDRTGYYHHDPYYTPGYNRGYGNGWFGSSSGNTGWFSGNSGNTGWFGGNSGNTGWFGGNSGNTGWFSNRGSSGSTFGTTHRRSSPTSSSSGSSTSSGFGGTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHN1</accession>
    <name>A0A6P8IHN1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate receptor ionotropic, NMDA 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116301393</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566306.1">
        <property type="nucleotide sequence ID" value="XM_031710446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHN1"/>
    <dbReference type="GeneID" id="116301393"/>
    <dbReference type="KEGG" id="aten:116301393"/>
    <dbReference type="InParanoid" id="A0A6P8IHN1"/>
    <dbReference type="OrthoDB" id="5958792at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027835087" evidence="13">
        <location>
            <begin position="20"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="822"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="431"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="436"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="953"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031566306.1"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113817" checksum="9B764DB3FB708359" modified="2020-12-02" version="1">MSVISAGLIMLLLTTVTESRVFNVAIILNISDIKQNNILSEATKVINQTQNEIAGSSSTIRFTEQHLPTFPSTPKNVLESHLNFTSNITATTDLVIFMEISINSLILADILKDLYIPTIGIQHREIGVLSSESLNLFTRVPTQSLIRDTAFVIKDIINKMGWRRIGLLTTADQEGLQLATIFQSFSLDENWETLEIAWISFDTNLNRLFQDIVDFKPDLLVIHGQGGKVEIFDAAKFFTCPLLMTSSVFDGILTENTPSGVLKLSLRKVIPDADHHFNVQMLSESMALVQNAFSDTVQKLCENDIDRTNCENALNKRLVREQVSSYISNYSKAGSVFFIPGPKDLPAQVFDIWNLRTDLRGHKYWLEIGMWTPAGIALDSFVIQNEKKFTPSLHNPRPTLRVPVVGVPTWMEVGEPYNNKPEGECLSGKPCYSYEKIGNSNEVTRIKHCCVGAVIDLIILLENDLEFKSYIYFAPDKKWGIYNETSKNWNGLMEQLTTGKGDVTALLGIDKARYQSVGFTQPYMNLGMNILVRKTDIPYFWAMNWKFLEPFKIELWLTITCVSNIFLLVIWGLDRLSPHGHRRRISLLQEEDSPTKDNGFSLLDSMSYVWGVAFSKDIGAENTPRSPSARFVSIFFGFMALILVNTYCANLTAVLMQDKFSSPINGIRDKKLVDPLLYPPDGFQLGVVRGSLEEWYFKNHKDTQIQLLYNVNIKINLVDDYEGGFRQLQDRKLDGLVGDEISLQAQANLANCDYNLIGTKFYEFGVGFAFKKDSPWLHKATLSVLKNQENGTIEHIKKLRFPSKPCEKLSFRRFNIDDFSGLFITVLLVIMFGILALVAELFIIFILIKYWEFLGCFGRKLRYFIFGVKESDRHLIDIQWISAFGRSFGKSWDVNIKTPQASLNNGHIMYQNGFSAKNGIKNDGFFISDDFSNGLFSATRASGRSLTSLHSFEMREETTQRSSHSSSQYNRHKKNKNKSVRIAEANDIRQANTDGMVYSNGTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIK2</accession>
    <name>A0A6P8IIK2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB/POZ domain-containing protein 6-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116301612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566559.1">
        <property type="nucleotide sequence ID" value="XM_031710699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIK2"/>
    <dbReference type="GeneID" id="116301612"/>
    <dbReference type="KEGG" id="aten:116301612"/>
    <dbReference type="InParanoid" id="A0A6P8IIK2"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031566559.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55398" checksum="5244ED1CDB52BE6E" modified="2020-12-02" version="1">MEASAWQTKLSSFKERHLYAYNKSLFCDVEFSVMDANGDKVPIPAHKYILAISSPVFEAMFYGESAETGRTIDLPDCTKEGLQEMLLYVYSDEVNLTGSNVLQVLCLAERYMLPLLKEKCEAYLEKELKPEEVFHVLPHVRNEKVEQKCWDMVDSDAERAVSSESFLNVSKEMLGKVLGRDTMSIDKVVLLQAVEKWALNKLKEEGLEESMENKRALSTWGRSDQTYSISTDVTEKVAEKVEIFKDTTTELVQTFSGLCPLKRSVSNNRKGSYKAKVIIPNTRFAKIRKPGGGRWSYLNGKSDAISFKVNKPLSLAGVRLFGDEGSTYHVNLALYKSARPIKHISSPFSTEDEEKDGYYGFTIPHKPVPLDPDVLYTIEATISGPCSYSGFKGETTIAFEDIVITYHNCSYKKSENQTSTEWGQFPTLEFEIEGGNWKVRRQSLTEDGKPTVEVNGIVVTFMSSEKSQNGTSEKKGQFPTLIFRKKDDLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJW5</accession>
    <name>A0A6P8IJW5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Coadhesin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116301756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566733.1">
        <property type="nucleotide sequence ID" value="XM_031710873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IJW5"/>
    <dbReference type="GeneID" id="116301756"/>
    <dbReference type="KEGG" id="aten:116301756"/>
    <dbReference type="InParanoid" id="A0A6P8IJW5"/>
    <dbReference type="OrthoDB" id="8889285at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF20">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028425144" evidence="7">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="227"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031566733.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46024" checksum="1DBAB7077DBBFA58" modified="2020-12-02" version="1">MQRNTAEVLVFLIWVVAAFITKTAESSASCPRVEKIGCFIDTLIPRPLPELLLTDRDPTDPVYSGNTINWYNFMDYLKGLVCRCAERTKERGFTHFGLQFYGECWSGPDAESRFAMHGPSKQCLMGLSIPPAYCNRTDTKACVGGPHLNYVYKIEEDRPKDPIDGKWSPWGPWTSCSTTCGPGTRSRIRECTNPPPENGGKTCAGNETQHGDCNVGKCPTPCHRDLDLGLVLDSSSSVGVERYQTAKEFLVNLVTNAQGSFKGTRIGIIVYNQEPQLQLTFNQTAALSLGEIMNVIRAIPYLHGGTRTDKALLKAATDLYTKKGGDRESVANVLLVVTDGRTNHLSEPYGDALKPLKERKVHVIVVGIGEGVKKSELLQIAMGNHNHVVTLADYQDLQAKLSDIVDEVCSAGNGVNRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK41</accession>
    <name>A0A6P8IK41_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="12">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116302200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567291.1">
        <property type="nucleotide sequence ID" value="XM_031711431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IK41"/>
    <dbReference type="FunCoup" id="A0A6P8IK41">
        <property type="interactions" value="3055"/>
    </dbReference>
    <dbReference type="GeneID" id="116302200"/>
    <dbReference type="KEGG" id="aten:116302200"/>
    <dbReference type="InParanoid" id="A0A6P8IK41"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031567291.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="59822" checksum="B803047634BF1778" modified="2020-12-02" version="1">MQPGIILLKEGTDSSQGIPQLISNINACQFIANAVRTTLGPRGMDKLMVDNRGKSTISNDGATIINLLDIVHPAAKTLVDIAKSQDAEVGDGTTSVVLLTCEFLKQVKPFIEEGVHPQIVVKSYRKAANLAIKRIKELAVPVKKDDPEEMRKLLERCAATAMSSKLIASYKEFFAKMVVDAVLHLDELLPLNMIGIKMVSGGALEDSMLIKGVAFKKTFSYAGFEMQPKKYKDCKIAMLNVELELKAEKENAEVRLDNVEEYQNIVDAEWDILYDKLEKVVKSGAKVVLSKLPIGDVATQYFADRDMFCAGRVVEEDLMRTMKACGGAIQTSVNGLTDDVLGRCELFEERQIGGERYNIFSGCPEAKTCTIILRGGAEQFMAETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIAGKEQLLIGAMAKAFEIIPRQLCDNAGFDATNVLNKLRQKHFQGGLWYGVDINREDIADNFEACVWEPAVVRINAITAACEAACLILSVDETVKNPKSSDAAGAGAMPGIGRGRGRGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IK94</accession>
    <name>A0A6P8IK94_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Snaclec 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116301846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566858.1">
        <property type="nucleotide sequence ID" value="XM_031710998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IK94"/>
    <dbReference type="FunCoup" id="A0A6P8IK94">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="GeneID" id="116301846"/>
    <dbReference type="KEGG" id="aten:116301846"/>
    <dbReference type="InParanoid" id="A0A6P8IK94"/>
    <dbReference type="OrthoDB" id="5971167at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="51"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031566858.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18152" checksum="591B74AC2BAE5543" modified="2020-12-02" version="1">LEDYCDAGKHNCSINANCTAAAGTFKCSYTDGYQGDGVICDRACKLGWHLFGGSCYHVYTETKLWQDSSLACQSNQANLVSITSLQENNFVHSLIRSAVVSAVWIGLARSGSPSTLSWSDGSTLSYNNWYRNEPDSSGDCVYMRTRDSKWLDESCTFTLGFVCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKA7</accession>
    <name>A0A6P8IKA7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC116302116</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567187.1">
        <property type="nucleotide sequence ID" value="XM_031711327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKA7"/>
    <dbReference type="GeneID" id="116302116"/>
    <dbReference type="KEGG" id="aten:116302116"/>
    <dbReference type="InParanoid" id="A0A6P8IKA7"/>
    <dbReference type="OrthoDB" id="6019542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031567187.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="55399" checksum="49A97674DFD64B06" modified="2020-12-02" version="1">MADKDEKSGDNSEHDASTPLNPKEEQPADQDPEAPVVQDNLNRVELKKSVTLLSGISFIVGTVIGSGIFVSPTGILVTSKSIGLSLIVWLGCGVLAMLASLCYTELGTAVPKSGAEYAYLMKAFGPIPAFLFAWTGIVINRPAICAIVSLIFAEYVAKPFFLDCRPPEAVIKLLGLSCIVVVTGINCWSVRWATRVQRIFTYAKLLCIALLVIIGVVELCRGRTENLQNAFENSETDPAKIGFAFYIGLWAYDGWNSLNYCTEEMKNPSRDMPRAIMIGISLVTACYLIVNVAYITVLGGSGILKSEAVAVSIGNAYLGPVNWIIPLFVAASTFGTVNGVAFTSGRLTYVAARDGLLPSLLAMIQVKRLTPLPSMLLTSTIAIIMVIPPGSNFMNLVGFFSFAAWLFYGGSFAALLWLRYREPNMPRPYKVPIVIPIFMLIASTYLVIAPIVAKPLGSLIALLIVVAGLPFYFFFKSNLVPQWFRNAIDDFTYGSQKVFNIAETEPNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM65</accession>
    <name>A0A6P8IM65_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uveal autoantigen with coiled-coil domains and ankyrin repeats-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567483.1">
        <property type="nucleotide sequence ID" value="XM_031711623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM65"/>
    <dbReference type="GeneID" id="116302341"/>
    <dbReference type="KEGG" id="aten:116302341"/>
    <dbReference type="InParanoid" id="A0A6P8IM65"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567483.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51029" checksum="74F0E5D22C2C4DBB" modified="2020-12-02" version="1">MAVAPAQFNVVLGFSQTPLTQALENKNFQEALDFINNRYGGCFDEGYYRRIPLYIVLSGEKTCYGKVMPVHLDIARRLIERGANPILRIPESIGAEYIGPGRSPIECVVDLYNTVTAYDLGSTPTDIAPSFPAVLMNGQRCTSVRDLIDDLISLVWMLLGHGAEVNVRDAENKTPLHNTLIRSADLRLAEILCDNGANVNAADRCGNTPLMAVCNPMPWRYYEEYGPAASGYDVSRAIFYLLRFDNLKINSCGVHGRTALFYAMQSGNFHVAKILLERGANPNMRGMGPDGSYISPLLASLIPWTALDRKDIKANLQAVATLVDEGFFSTPEILKEVLEYAVDDNGSKILQQNLLHKGVNLIQLLFGQGSAPLTQLAARTAIEHKFPNLEFSSMSSFNVSNLIRSQGLPLELITHLEVVLLREKILHVLSEIDWDEWDVEEYSLNDSDDYDESDDEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IM96</accession>
    <name>A0A6P8IM96_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116302872</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031568126.1">
        <property type="nucleotide sequence ID" value="XM_031712266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IM96"/>
    <dbReference type="FunCoup" id="A0A6P8IM96">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="GeneID" id="116302872"/>
    <dbReference type="KEGG" id="aten:116302872"/>
    <dbReference type="InParanoid" id="A0A6P8IM96"/>
    <dbReference type="OrthoDB" id="5986427at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000006">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="199"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031568126.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="49765" checksum="BABD982D38D3A35E" modified="2020-12-02" version="1">MNSFLKYLKWMLVLLVITTFITILFVYEAAREQVFYLAEKLDLVKPSWMSWMAPLSNVTGGYKIILFYTPYFRSMPWPQARGKEKRLTDPYGRKCKVSSCYVTYSRQDFSKSNAVVFHTSAMPSLSRMESLLWKKTKGQKWVWYGQENPENMPFSAKTYSNMFDWTITYRTDSNVLDRYGYYVPITSNKDEFTKKNFIAGKDRLILWLASNCVSFRLSVVKEISKYLHVDVYGKCQRYFDHQPKGSCTRGSGDCDKMARRYKFYLALENFNCRDYVTEKYWRNALAHEVVPVLVAGSYSKDVLIPGSYIDILDFPNAKSLASYLKYLDSNDTAYNRYFEWKKNYTSVTTTNWLCDLCELLHRNDSDQEKEPLDMGTFWGTGNCHADDAYIRNVWLKSDARGRDSLGLCCLSFLYSILLLGFHVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IND1</accession>
    <name>A0A6P8IND1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC116302795</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031568025.1">
        <property type="nucleotide sequence ID" value="XM_031712165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IND1"/>
    <dbReference type="FunCoup" id="A0A6P8IND1">
        <property type="interactions" value="1788"/>
    </dbReference>
    <dbReference type="GeneID" id="116302795"/>
    <dbReference type="KEGG" id="aten:116302795"/>
    <dbReference type="InParanoid" id="A0A6P8IND1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="17">
        <location>
            <begin position="366"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="546"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031568025.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="75265" checksum="EBB90A6D46B164E6" modified="2020-12-02" version="1">MPALVAFNRRWQIGSDDLVFVFAGGLMARIAWVTVLCIIFGVYHSQIRLCTASFALQSFFIGVIALTFIVILNEIAIIWMSMRGSVINTRPRRHIPILLYIQIALYVPETCLSALGIYWAFYESKGCEDGLTIPVKITVVLQWCLFLTVLVVVVVFFDPLGSTQITDHGEDRRALQEKTTKIWERRCKVLCCCFASCDEDYRDAISDIAGMFASELHGIDAVPSDVAAGLILLQEQQEEEERQKIQDGQTSSEGVPVDLSDPSQKKLIDDAAHFMKYSLGSYGWPMYVFMNPCCGTFHFCSKVRWLSCLGPRAKHIINDNCCMCNSAAIHLQSSLPESDLIYCTYHNKLYEIPFYVAIDDKAKAVVISIRGTLSMRDTLTDLTGHGERIDMEGVEDGMAHKGMFLSAQYIKKVLLDNGILQGAFDEAEDRGGNYRLVIVGHSLGAGTASVLSILLKPLFPGLQCFAYSNPSVLNESATVNCEDYVLSVLVGKDVVPRMSVKTLNTLVQDLENVIMNCNLPKYRILMTGCWRAICFFLGNNNKNRKGDPKVLPPSISPRTDQGSQPHITEPLLGKRGERQPLSSSTGGARSSYVSNNGGSSESESNRQRNESQLVRLFPAGKILQIDVKPKNRPRPGLAYDLTWANKENYDRVIICPTMVKDHFPDVVMNALRDITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQA3</accession>
    <name>A0A6P8IQA3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-lysine N-methyltransferase SMYD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET and MYND domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116303136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568473.1">
        <property type="nucleotide sequence ID" value="XM_031712613.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116303136"/>
    <dbReference type="InParanoid" id="A0A6P8IQA3"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF7">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="238"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="14">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="14">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031568473.1"/>
        </source>
    </evidence>
    <sequence length="668" mass="74925" checksum="24EC8513829B36EE" modified="2020-12-02" version="1">MEDEENVARSVYDQICNSLIEKKXLQETSVAFGKLKSDAERVKFVLNLTSVDQIIRIXPXSXQKSTEXSINARVEGNKLFQKKLLXKALKEYTQTIFLAPESDKKATALGYANRSAVLFHLHEYDLCLRDIKAALDNGYPDDSLYKLVDRKGRCLALLNRKDEAHSAFKEALECLAISSLKSKDKHLWKKQLEKQINQCLDTNEVQSPVNPVESVRAGCPTXVELSYGVNNKYTAASKAXDLAVSPLKGRYPIASQDIQIGDIILAEKPYASVLLSTHTDIHCHHCFVRLLAPIPCXQCVAVRYCSFXCAXESWKAYHSVECKYLKHIYSTGKYGHLALRAVIKTGLQQLRDVISKAQSSVNDPRMLGCNDIGVYDPSDYTPIYHLVGHTEDRAINDLFKRTVTAVYLLKCIQETRFFDSSQGEQGSDKGTEESLILVGSMILRHLQSFPCNAHEISELQLSRKSVATSETTEIGAGIYCTLSLFNHSCDPNVTRFFYGDKCVLRAMKTIPGGQEIADNYGVLCALTPRDERRKALANQYYFHCECKACTEDAPLYSEIMKIXKPIFKCEGCGFPLTGSKDTVFTCKSCNSKQNIESKAKLLKDSEDGFAEAANKLLDKADVSSALPQFQHHLHYLEENVSQPWHGFNNCHELMKQCYNILANCNLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQK3</accession>
    <name>A0A6P8IQK3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 271-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116303191</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031568548.1">
        <property type="nucleotide sequence ID" value="XM_031712688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQK3"/>
    <dbReference type="GeneID" id="116303191"/>
    <dbReference type="KEGG" id="aten:116303191"/>
    <dbReference type="InParanoid" id="A0A6P8IQK3"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000017">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002284">
        <property type="entry name" value="Zinc finger protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031568548.1"/>
        </source>
    </evidence>
    <sequence length="849" mass="99562" checksum="1D33BADC075C045E" modified="2020-12-02" version="1">MSVSDQLDPDWYGYECKPGQLLFYYNKTTGEHRWNNNIPIKCEPFDDGYREWVSIKTEHDPCVDECLSMYIDASHDQETDHSDSQVNTEANYCKPFHIMENVSSQTNKVQGEVAQAEDNGCTSSSMDNIITMQDCPPKENDEITGADESNCEDLVGKTYSCVERTDTKRTKNISHDAQRSNLANENTKQQPAQRPKRMKDLTSNAFSMSTCSKGGRHEVLDCQDQSMQEMKRGLSCELCDLFVNSTYDYYHHLKSHCLEKSHMCPVCKKTHQQKSSLFAHLRIHCRTFTQNVHIEVHERIHSELKPYICTYCNRTFTRQVCLKKHELIHTGVKQYKCTYTNMAFRRQSHVIPHERIHTGVKPYKCEFCNEKFAQKDYLKVHKLEHTGVKQYKCTRCEKAFSRQSHLKQHERIHTGIKTYKCTTCTKAFTYGFDLKKHELIYTGIKPYKCTYCNKAFTRHSVVKVHERVHTGAKPYKCTYCKKAFRQQGHLGIHERLHTGVKPYKCAYCIEAFTRQICLKRHERFHTGVKSYKCKCCNKTFARKDNLNVHKLVHTGLKPYKCARCDKEFKRNDYLKAHELAHIGVKPYKCTYCGKAFMRQGHLKQHERAHTGIKAYKCTTCAKAFTYGFLLKKHERIHTGVKPYKCTYCNNAYTQQGDLKRHERIHTGMKKTCKCTYCNKAFTRQGDLERHERIHTGVKPYKCTYCNKAFTLRGNFKKHERIHTGVLPYKCAYCEKAFGQRYYLKVHERIHTGVKPYKCTHCNKAFTQQCTLNRHERIHIDRGRHLSKKTLSTHEHEDITKAKHRIITVFSKDMLKAIKCLYLFIQDFKIRSIKFCLLANRAFIKRQSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQP6</accession>
    <name>A0A6P8IQP6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate sulfotransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116303806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569269.1">
        <property type="nucleotide sequence ID" value="XM_031713409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQP6"/>
    <dbReference type="GeneID" id="116303806"/>
    <dbReference type="KEGG" id="aten:116303806"/>
    <dbReference type="InParanoid" id="A0A6P8IQP6"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031569269.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="48829" checksum="B1334E74B6B179B0" modified="2020-12-02" version="1">MCFGVDQHNTYEQNDYPYRMARRVSNTRGGRILLILIIVAVDILTSNVFLHTSSKLFRLFSSFTKRSIEMGYISKDIDKQTRTNLIILSHSRSGSSFLGQIFNHHPDVFYMYEPFYIMKVTTLDQSNFYESSALRLLDDILNCNFKNQEEYMGFLNHLPHHRYSSRSLTVPFCAPNQTDTKFGKTVRYFCKPLDPWETSRVCSTHKHRVIKLLTHRIPNFKVNFFKPLMKSEVNVKILQLVRDPRAIVASMERVGWIQSYTQFNSKQTFIRTSFHDFEQRVKRFCFSLLDTIKFILEAERKLLGRYKLVRYEDLVQQITTKTDDVMKFAQFRSSDDVTRWLQRSTHAENTAVRKKNYDYSTERVNISHLADSWRRTLNRQQIVVVEKYCKPVMTMLRYPVVFTDHVQKGFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR47</accession>
    <name>A0A6P8IR47_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="16">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC116303934</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="16"/>
    <dbReference type="RefSeq" id="XP_031569419.1">
        <property type="nucleotide sequence ID" value="XM_031713559.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IR47">
        <property type="interactions" value="1136"/>
    </dbReference>
    <dbReference type="GeneID" id="116303934"/>
    <dbReference type="KEGG" id="aten:116303934"/>
    <dbReference type="InParanoid" id="A0A6P8IR47"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23532">
        <property type="entry name" value="TFP_LU_ECD_BMPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000021">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027917342" description="Serine/threonine-protein kinase receptor" evidence="17">
        <location>
            <begin position="24"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="19">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="207"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_031569419.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58279" checksum="3FE7FDCECDA80F53" modified="2020-12-02" version="1">MSNFGRPALIFLAFCAVLQVSNTVRCKCTEHSCPGDHVNETCTTTGKCYKKIEEKDGYELITLGCLAPEDQSYMQCNTPSSVHRDKISLLCCNGKDLCNYQLDPTFLPPTTLSLDDEPSTEESSVATKQYFYLFVTAGACSFVFVVFLIVLYLRFREMRRRIPSHFTYDRHSTFISSGETLKDYFDQSSGSGSGLPXXVQRTIAKQVTLIQSVGKGRYGEVWKARWHGEDVAVKIFLSHCETSWMRETEIYQTVLLRHDSILGFVASDIIGIGQVTQMYLITDYHSLGSLYDFLRIHRLVKKVMGKLVFSAAAGIAHLHAEIRGTQGKPMIAHRDIKSKNILVKENLTCCIADFGLAVKYIQDSKSIDVKSDTRVGTKRYMSPEVLSHTLDSKSFDAYRMADMYSFGLVLWEIARRCISDETGLCEDYEVPYYDLVPNDPSFEDMKKVVVIDRKRPDIPNRWRRDETLRVMGKLMSECWSHNPSARLTALRVKKSLDKIVSLNREPITPENPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IR75</accession>
    <name>A0A6P8IR75_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116303903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116303903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569372.1">
        <property type="nucleotide sequence ID" value="XM_031713512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IR75"/>
    <dbReference type="GeneID" id="116303903"/>
    <dbReference type="KEGG" id="aten:116303903"/>
    <dbReference type="InParanoid" id="A0A6P8IR75"/>
    <dbReference type="OrthoDB" id="5968137at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569372.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23682" checksum="66D067F37219DB8C" modified="2020-12-02" version="1">FAAGYTNSGVYEITTPNTSKIDVYCDHGNEDSGWTMVFKAVSGVPLQQQGPSVLWLSNSLLESSSSALSINSSSRQHYKNRIVEHWQAFNPTQVRLSLYKDKKEVVLLVFNATGSTKTNWFSRVRLLTSPWTDIHSQPVNYFSINGDIRDILRRTFFINSQYVDCSLDLGWMVLEEKIPGGCTWENHFQHFSVLYSPTNSRVLWSNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISJ8</accession>
    <name>A0A6P8ISJ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17 18">Protocadherin-19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17 18 19" type="primary">LOC116304368</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16 17 18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031569953.1">
        <property type="nucleotide sequence ID" value="XM_031714093.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569954.1">
        <property type="nucleotide sequence ID" value="XM_031714094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569955.1">
        <property type="nucleotide sequence ID" value="XM_031714095.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569957.1">
        <property type="nucleotide sequence ID" value="XM_031714097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304368"/>
    <dbReference type="KEGG" id="aten:116304368"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653228" evidence="13">
        <location>
            <begin position="17"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="792"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="129"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="242"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="355"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="462"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="567"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="668"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="891"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031569953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031569954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031569955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031569957.1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112847" checksum="2628D9C112616200" modified="2020-12-02" version="1">MIVLFITITLLQLSVAKTTTIKFQVKEEQNAXAFVGDASQTDPPNRLIKGNFKIRFAIQDPTQTIFKIDQKTGILRTNQVLNRENLPPSARGDVFQIQIVFSDDSMGITGVLPTEVRVIDINDNDPKFPTDFEELRISESAPLNSRFQLVPATDADIGNNSIQSYRIITGNEDGMFALKLLKPSANVMYLYLVNVKRLDRETKDFYRLVIAAVDGGTPLPRSATKILNITILDSNDHSPEFTKFNYIGKVRENMPNGTFVVRVEATDKDIGTNGIVRYSLDPLPEYHGLFRIDERTGEVWTNAVLDYENDSGSRYVLSVSARDLGPDSIPSMASITVEVIDENDNKPVIIALPVQAVLESGRIPEDIPVGRAVASIQVNDKDSPNNSMIDLRLINHKHDFRIKTIFPNSNYLLVVQRPLNLSRKAWYDMKLXARDSGVPSLNSTSPIFFRIADKNRHAPNFTKSVYXVKVVDDVKPGTHIASIAAYDPDTDREGDLEYSINTLRMGNKNVSNPERFFKYDKKTGNLKVIPKLWCSFTPSFDLVVEARDNGRVRRRGSAVVKVTVLCAKYQYNFTIKENQPKGSVVGRVVVDPPSPGKKLSFKIVNDARKDFIINNASGFITTARMLDRESVATHSLVVLVTDGLIDMRLTVLVHVEDVNDNAPIFIGLNDNHEVSLPSTAKRGDEVITVRATDPDTGSNGRIQYTLESGNDDKTFILDKDRGVLVVFDYLFEPSYELKIKATDAGEGSKTAYVTLRVVVALPKYLQSTSRPSKVPIYDTQEGNGXLLASKTILIVVILCSIVSLLVVVVIVVVVIRCYRRQGETKTHKCTPLQRDSNFREPEISREAAIKASKQMYSQATVNMYASNEMLEIKKPKNLKMGQAQPLPLKSSFATSPTGVNASPSHRVNNPPPYADIYPPISTTRPVSECFSSGDELDSGRGDSSLPSSPYSCHTLGKTNNDHTNHYSTYKHPKRDSTSYNHYNHPVVTLPNRSQSGKKKTVTIAPDALPHSSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISZ8</accession>
    <name>A0A6P8ISZ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pleckstrin homology domain-containing family F member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116304452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570047.1">
        <property type="nucleotide sequence ID" value="XM_031714187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISZ8"/>
    <dbReference type="FunCoup" id="A0A6P8ISZ8">
        <property type="interactions" value="976"/>
    </dbReference>
    <dbReference type="GeneID" id="116304452"/>
    <dbReference type="KEGG" id="aten:116304452"/>
    <dbReference type="InParanoid" id="A0A6P8ISZ8"/>
    <dbReference type="OrthoDB" id="70570at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15717">
        <property type="entry name" value="FYVE_PKHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01218">
        <property type="entry name" value="PH_Phafin2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000167">
        <property type="entry name" value="Pleckstrin homology domain-containing family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037871">
        <property type="entry name" value="PH_Phafin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570047.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30991" checksum="9D85102DD4FC444F" modified="2020-12-02" version="1">MVDRLVNSEANLRRIRGVEACFGSSGQPLVVPSRVLVGEGVLTKLCRKKPKPRQFFLFNDILVYGNIVINKKKYNKQHLIPLEQVKLLSLEDDGSLKNGWQIISTKKSFAVYAATATEKAEWMAHINKCIQDLFAKTGKKASDNHAAVWVPDSEASTCMHCMKSKFTALNRRHHCRKCGAVVCGACSAKRLSLPAQSSKPLRVCNTCYQAVMSKAKNPDSKKTDAVPAPSKELKGDEDSSGEENSDEEEAGGETAEVQPPSTPTFYQENPPSEQKPAEEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT22</accession>
    <name>A0A6P8IT22_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-1(II) chain-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570072.1">
        <property type="nucleotide sequence ID" value="XM_031714212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT22"/>
    <dbReference type="GeneID" id="116304474"/>
    <dbReference type="KEGG" id="aten:116304474"/>
    <dbReference type="InParanoid" id="A0A6P8IT22"/>
    <dbReference type="OrthoDB" id="5986542at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570072.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="22911" checksum="64FB5C6BA6835594" modified="2020-12-02" version="1">MPPKKAAKETSTSNGNIPFFQIFIFLIATVSMAINFGIITGKIPIKGCVGPAGKDGEPGLAGSPGERGLQGAPGDKGPKGDQGERGPQGIKGDPGPLGPEGPSGAPGTNGEPGKDGAPGSNGTDGAAGENGSPGEKGDTGEQGPQGPEGTPGPVGPEGTPGPVGPEGAKGDKGDPGVDGKQGPQGDKGDQGPIGNPGPEGPQGPPGDMGPQGPPGDMGPAGPQGPPGPSAEVGAADDADIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITR0</accession>
    <name>A0A6P8ITR0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116304964</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116304964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031570631.1">
        <property type="nucleotide sequence ID" value="XM_031714771.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304964"/>
    <dbReference type="KEGG" id="aten:116304964"/>
    <dbReference type="InParanoid" id="A0A6P8ITR0"/>
    <dbReference type="OrthoDB" id="5976724at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000003">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="488"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031570631.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="68595" checksum="54DD79903E1C72E8" modified="2020-12-02" version="1">MASSLQWAAPREMSFEGNVSENYRKFEEHWNLFEKTELKGKXEEERCSYFLLCIGEKGREVYKTLDLPDETTTDDKGETVWNRTTADIKTAFKTYCNPRKNITFERHKFNTRNQEQGETIDQYVTVLRTLASLCEFKDLKDGLIRDRIVCGISDQSLRERLLREADLSLDKALNICRASEHSRQQLKTISEAKNANVDFVKQRQPRYNERHTPTQTRTTGDSKQKPCGNCGILHRPKSCPAYGKECNSCSKLGHFAKYCRSSQQQQQFQQKYQTRNHRTRVHEVEYDVIESDYSDQITIDSVNESIDHNEQYADIRIGNKDLKLKLDTGAETSVLTKEDFYKVVPRKRRREKLQSSHARLTAFGGHAIPIIGQCSLMCQFKNIKQIVQFQVVEAGKSLLGCEDCETLQLITFNAHEMERNTDSSKLIGLSKEEILKEYSTCFEGLGRISEPYHIKIDSSVSPVIHPPRKLPSALREKVKDELEHMERAGVITKVNEPTPWVNSMVVNEKRSGKLRICIDPRDLNKAVKREHYQLPTQEEITARLSGAKFFSHLDAQSGFWQIPLDEESSLLTTFNTPFGRYRFRVMPFGFVFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IUU0</accession>
    <name>A0A6P8IUU0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo repeat-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116304356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569945.1">
        <property type="nucleotide sequence ID" value="XM_031714085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IUU0"/>
    <dbReference type="GeneID" id="116304356"/>
    <dbReference type="KEGG" id="aten:116304356"/>
    <dbReference type="InParanoid" id="A0A6P8IUU0"/>
    <dbReference type="OrthoDB" id="201709at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031569945.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9248" checksum="374A38EB8FD99435" modified="2020-12-02" version="1">MFTSQEHIDYKCGADGLGRLEYLQALVTEYQDTSKEGNKEQVLANLANFAYDPINYGHFKKLNVADLFMESWRPGTKARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV71</accession>
    <name>A0A6P8IV71_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Probable serine/threonine-protein kinase ireA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC116304447</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570042.1">
        <property type="nucleotide sequence ID" value="XM_031714182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031570043.1">
        <property type="nucleotide sequence ID" value="XM_031714183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116304447"/>
    <dbReference type="KEGG" id="aten:116304447"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
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        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="188"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="7">
        <location>
            <begin position="458"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031570042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031570043.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="68104" checksum="BFCEA12E9CD0BBDD" modified="2020-12-02" version="1">MKRNAETFFETSRRSLFLGVLTSEEKEEEKKSEMLLRKRRCSWAIAKDMRKTNETLQKSLFLRTDTSKEDDVEEKSEVRSSLSVAPYRVTSEGDKKNFLFLKPWPRTVMEDMGIKRNATFQKSTSEDDEKENSKASCRSKLSRLSPTAQRKLKEDIGTSTKRSGPIVLKAQSSEDEGEEEMSTVSSYKYSKKPIGFGAFGTCVYSGENTKDRRKVAIKKVNCHTQRQIRQYKREVKYLLVLSGCPNIVKYLDVVVKQNVVYIMLELMEGTLETLVNQPNLMHNIKFTEVCYDIISXLHFLHNQSNKTIIHRDIKPRNILFVSSPRLMLKLADFGLSKMLDSDSSSIGYNGGTRCWMAPEVHRSLDQFSTASDVFAAGLVLHYLMTSKNPFEPTDVECTKENRLYVEHKTVENILSQNLNIQNSLSPEVDHLIDQMLKDEKDQRPNAEKVLAHPFFWSNQKKMKFLEATANQPEIFQKCTSDFKKDLALTQLEAQFQTVRWSEQSPTMVYIYSRMMMAGRRKYNTTSVAELLRFMRNAYQHVSEPGRTTLFKEYLLKDFIFQKEFKSLLMFTKLFKSINGIKTKRKSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IW63</accession>
    <name>A0A6P8IW63_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stromal membrane-associated protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116305748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571591.1">
        <property type="nucleotide sequence ID" value="XM_031715731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IW63"/>
    <dbReference type="FunCoup" id="A0A6P8IW63">
        <property type="interactions" value="2538"/>
    </dbReference>
    <dbReference type="GeneID" id="116305748"/>
    <dbReference type="KEGG" id="aten:116305748"/>
    <dbReference type="InParanoid" id="A0A6P8IW63"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031571591.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="52274" checksum="614061CF89E19C79" modified="2020-12-02" version="1">MSTRAQREKGQTQNANQAILAGLLKEESNKYCSDCGAKGPRWASWNLGVFLCIRCAGIHRNLGVHISKVKSVNLDSWTPEQMTKIQDWGNRRAGMYWECFLPKDFHRPQTNSAVETFIRNKYEHKKYAKKDGMPPKAIVQESTSIATKVNKPEKVVKKKKLIDEQNGISVTAQALSDKVVAPSRTTAPVSRPKPRVTATAPPAVQSSAPSVDLLSLDTPAPVANQTQNPVMQIPNSSPSAELIDFGAFQGAPQILSQSPPSQPQQLASMTQSAPPVDNEESLLKDDNTTKKSTKDSIMALYTGGGSTAAQQPHMYGVPGGMYLQQQPQMHKTPANVYKSPLQTPYHPQPHVMPMHMQQHLMQHPTPHQQQAQLSQIQQQMQQLKVQKNQQMPPFPQQQQQSHQQPNMYGNNTMFTQQHAMKNIMTQQQSMHYQKQQQPQFISTGPSTNMFPMNGMPSSGHTFNNQLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IX30</accession>
    <name>A0A6P8IX30_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">methylenetetrahydrofolate reductase (NADPH)</fullName>
            <ecNumber evidence="7">1.5.1.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116304937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:19819"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.53" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031570598.1">
        <property type="nucleotide sequence ID" value="XM_031714738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IX30"/>
    <dbReference type="FunCoup" id="A0A6P8IX30">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="GeneID" id="116304937"/>
    <dbReference type="KEGG" id="aten:116304937"/>
    <dbReference type="InParanoid" id="A0A6P8IX30"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="341"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031570598.1"/>
        </source>
    </evidence>
    <sequence length="656" mass="74065" checksum="AF50E31217BA86AD" modified="2020-12-02" version="1">MGLGQQEPATPTIEIIQDLENQSKSSSPISVPSTPLSLIEKIKNKIAMDEKFFSLEFFPPRTPNGAVNLLGKFDRAARGCPMFCDITWHPAGDPSGDKETSSMTVASAALNYCGLETMLHMTCANTTKDDVTKHLQKAKGLGIRNILALRGDPPDGDEWKALDDGLAYGTDMVRHIRKEFGDNFTICVAGYPAGHPDCNNYQEDIQHLKEKVDAGADFIITQLFFENKTFFKFVKDCREVGITVPIIPGILPIQGYASLRHLVKLSRLEIPQSIIDALQPIKDDDEAIRKLGIQMALDMCRELLDSGIVPGLHFYTLNREIATREILCALGLWCSDPAASRPLPWRASANQKRFTEDVRPIFWASRPKSYLYRTSEWDEFPNGRWGNSSAPSFRDLSDHHFFYLRSRAKIDERLKMWGTKLERVEDVYEAFSCYISGKENREGVKVKSLPWNDDELASETDIIKAKLEYLNSEGILTINSQPAVNAKPSTDRLVGWGGEGGYVYQKAYLEFFTSPETVSILLEVLKDYPLVNYHVVNAEGTVDITNCHQDTPVAVTWGVFPGKEIMQPTVVDPISFKIWKDEAFSLWEQQWGRLYPEESRSRKVINEIINTFYLVNLVDNDFVKGTCLWHVLDKVVSIAKSKEDTKESHTSQPMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXM1</accession>
    <name>A0A6P8IXM1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Vacuolar protein sorting-associated protein 33B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116306031</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031571918.1">
        <property type="nucleotide sequence ID" value="XM_031716058.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571919.1">
        <property type="nucleotide sequence ID" value="XM_031716059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116306031"/>
    <dbReference type="KEGG" id="aten:116306031"/>
    <dbReference type="OrthoDB" id="10262528at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031571919.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="66220" checksum="B17134AC609F6857" modified="2020-12-02" version="1">MATGTGSLPNFSFLKNIVRDQLTDVLESFPGKKDLVIDPKLMKPLDHVAGATFLKDHGVNKIFKLEKQKLDVECDKRIYLLRPSMVLTRYVADHINSDKQNHVTREYKIVFAPRKMYVCEMVLEQEGVYGDATLDELAFDIIPLDQDILSLELPEFFKDFFLDGDQSWVYSIAKSLMILQSMYGTIPEIYGLGXSAKMVMEILEDLIKEEGEYKPVDGPEIGSLIIIDRDVDLITPLCSQVTYEGLLDDTFGTKSGFIEFGPDVTGKDQTAKLLLNSNDAVFSDIRDRHFSNVFGYLSQKAKVLQSGYDKRHELSSVTDMKNFVSVELKDLRQQHKSLALHIGACEVVLKKKANEDFERLLQTEHNILELADNKDSLVYIEECMMRQFSSTNALRLLCLLSLTHGGLDPKLHKTLKQQYLLSYGYEHLNTFVNLKKLGLFTETDRKNIFKVTSKRLNLVPRSAEEINLKNPSHMSYVFGGAYTPISCKLVEQIQHGAGISSIEDLARLMGVEVSXMRRPXSVRHPSAGSPPKKRPTLVMFMGGCTYSEITALRFLGKLKGCSYVIGTTSITTSRRTLTSIIEHTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IYH8</accession>
    <name>A0A6P8IYH8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-protein ligase E3B</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HECT-type ubiquitin transferase E3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116306613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031572556.1">
        <property type="nucleotide sequence ID" value="XM_031716696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IYH8"/>
    <dbReference type="FunCoup" id="A0A6P8IYH8">
        <property type="interactions" value="1611"/>
    </dbReference>
    <dbReference type="GeneID" id="116306613"/>
    <dbReference type="KEGG" id="aten:116306613"/>
    <dbReference type="InParanoid" id="A0A6P8IYH8"/>
    <dbReference type="OrthoDB" id="6019025at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000012">
        <property type="entry name" value="Ubiquitin-protein ligase E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="696"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031572556.1"/>
        </source>
    </evidence>
    <sequence length="1064" mass="122032" checksum="7C1EF12728A0EB12" modified="2020-12-02" version="1">MFAGSDNKKNESVVSKAQAARQQRAEERAKEKAALKIQAWTRRVVCVSKLRKQIREEFDAFLEEESSSSKTSAITVFHKIRRFLFIFQDKYDAKRLVSLCRIILSSMEQNNPKVWYISVALSQDLILLWIQQVKNILWHCCRLMRKLKPHIGNDSKEIIIYLNMLITLTDCSKWKILTAKGGDALKPSFQQLCSNILGFLNTKGFYPVLKDLLMNGLARSSPSLKVVPLTAATTLSLRSLVLSQFSENLCSLFILNILSVPGLVLHLSSIAPEMLKRFQSIMLFSKVIDFMKSEQRSRITYNSLECGYSLCLLANIVSLSQLGDEALKQNLRDFIVVVSRVLLYCQSYVAKKQSSLTNWHPLLGWFKQNTDQRLNDSIPHVTKQLQILWHRSTVQLLFEDLKAVTDLDKEAQSREQNRKDSKSLWSLFGSLQRGNRSSIKVSQSQVELVSNVCVMYQTMVTTFSLIRLDILTGLSYQEEFLVRLWRFFVLIGNNGGPELVLNSITRSGVNCSHALQSTLTLFFDCCGHLLPIVDDQEMYEQQKPFSLDDLVHMSTFLNKLVFKLYWNEITDENKPQSVSAETLLNSGHSLLMILYDRDCRRSFTPPNHWLIKEVKSNTFRAELAEGRRRACVILQKIPHVMPHIERVQLFRECVAKDKEVLGITRPNDDFVPQGTLITVRRNRLLEDGYDQLSKLSPKVLKGVIRVRFINEQGLPEAGIDQDGVFKEFLEETIKKAFDPGLNLFKTTTGDEQRLYPSSTSFVHDNHLNLFEFIGKMLGKAVYEGIVVEVPFASFFLNHVLGHQHSSMYSSIDELPSLDQELYKSLTFIKNYDGDIRDLDLSFAFEEDVLGKVVTHELKPGGSVIPVTNENKISYVHLMANYRMRLQHHNQTKSFIRGFKSIVRSDWLRMFSAPELQRLISGDNAALDLSDLRKHSRYYGGYHSGHRVVVWLWEILEKDFNDKEKSQFLKFVTSCSKPPLLGFEHLEPPFSVRCVECSDDEDDGDTVGSVIRGFLNIRRRREPVGRLPTASTCFNLLKLPNYHKKSTLKEKLRYSIQCNAGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ17</accession>
    <name>A0A6P8IZ17_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C1orf194 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116305434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571188.1">
        <property type="nucleotide sequence ID" value="XM_031715328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ17"/>
    <dbReference type="FunCoup" id="A0A6P8IZ17">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="GeneID" id="116305434"/>
    <dbReference type="KEGG" id="aten:116305434"/>
    <dbReference type="InParanoid" id="A0A6P8IZ17"/>
    <dbReference type="OrthoDB" id="10013535at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022179">
        <property type="entry name" value="CFAP276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12494">
        <property type="entry name" value="DUF3695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571188.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18458" checksum="D4FB93C0D5C29E06" modified="2020-12-02" version="1">MPRDPYPFPRLQNDTDFAGNQPKQVQKGKETMKDNGQQWDRLYKTATLSSSRREVFHYDPQAPQDSLDFVIKSRYDNHHEFLKSKAETLTQPETLGLQHGRVLKNRPPSPEPPIDIYKLPLMRSTAVKKESNNSTNGAIESHHSAATNGGYSRKHDGGFYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ23</accession>
    <name>A0A6P8IZ23_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel subfamily KQT member 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116306496</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031572429.1">
        <property type="nucleotide sequence ID" value="XM_031716569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ23"/>
    <dbReference type="FunCoup" id="A0A6P8IZ23">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="GeneID" id="116306496"/>
    <dbReference type="KEGG" id="aten:116306496"/>
    <dbReference type="InParanoid" id="A0A6P8IZ23"/>
    <dbReference type="OrthoDB" id="6020680at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="98"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="14">
        <location>
            <begin position="496"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="608"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="652"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031572429.1"/>
        </source>
    </evidence>
    <sequence length="906" mass="100756" checksum="929575FFCEFAC796" modified="2020-12-02" version="1">MSVMFRKGSTNFARESGDCDLSLKEARFQSYTLKSEEKASKGDECGSVVQNGPSTRLDLLGRPIPGARNRAHSEQYRKIQLACYNFLERPHGLSHLYHASICLLVVMSLFLTALSTVNTDDMDYWTILRTPVFVVEVILVLVFITEYVVRLWAAGCRSTYVGFKGRLKFAKKTYAILDILVIISSISALTLVATAKVPTTAVSLIRFLPLLRVLRFDRQGGTWKLLASVIYIHRKELVTTLYLGFISLIFASFVLYMVEKDANIKFDSWPNSFWWGIVTLTTIGYGDKTPITWYGRFCAALFAVFGISFFALPAGILGSGFALKVTQQQRQKHFHRRRRPAAILLQSHWRMYCADINSKSVATWLPHIYYNRRTSHEKTPYNNTVDSSQLPGSGAPKKGRKLSSVWKSRNEGKATRSQSVDVIRASRSDSAPMIDTGVTGQRQGSIGSTLDTSFFVPGENLHCTLVYTRKPMITSRTFASDEANISLSEDGETAITLTPAQKHAIRLIRLLKLNVAIRKFKEARKPYDVKDVIEQYSTGHVEMLSRMKSLQQRIDKVVLDRENALQDESSFRSSITCRLIKVEQQVTSVERKIDAILNILSKTTGADTTLYHHDEPGPSPPPDGHSPGSSTSRSSGLPTVIIGSDKMFDTSRLRSESLPSTAVAPEDISHWPPKHSQSDPVLPLNSIESMKPHRPRTPSLSSEDSTEGGQNMDCLNAPTVSSVAPNRILGNHGRQLSDVTEGDESVSSDSKENVLGSKFSRESTLDSIEDTNEPMSPSDDVDFPMYDPLLNPYAQDKSPKTTEEQPLVWEKKPHPDTKRTRSESHKTSSTSSFGTLVGEGSGNGSMEQDCCYSDVFQGSQEESSIDKEMPGASLVGESFDLDESVTSVDESKSKRRPLLRHSPIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZ84</accession>
    <name>A0A6P8IZ84_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing G-protein coupled receptor 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572499.1">
        <property type="nucleotide sequence ID" value="XM_031716639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZ84"/>
    <dbReference type="FunCoup" id="A0A6P8IZ84">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="GeneID" id="116306563"/>
    <dbReference type="KEGG" id="aten:116306563"/>
    <dbReference type="InParanoid" id="A0A6P8IZ84"/>
    <dbReference type="OrthoDB" id="5989349at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027552512" evidence="4">
        <location>
            <begin position="24"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572499.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="42779" checksum="0F8D9683EB75E1C0" modified="2020-12-02" version="1">MTTVQHMLFVLLLQFACLESFDAKQSIRSMKHTNGSHPCPQPTVGNCSCEWTGPYVKVTCVGLDTVPEKVPESALYITFFNGTIKEIPQNFFLSFKNLITLNLKENKISNKFKLPKSLFNLFLDNNCLNASTIFGMFDGLTRLRALHLSWNPLGEKLVPGTFSSVKNVIELTLANCLLEDVGENMFLGLTNLRTLKIFGNKIRTLKRGAFRGISCPKGETSLTLKLVDNLISHIEDGAFEGVHGLFRLSLDGNQLSSFPNLTGFPKFSDLTLSQNNIVDASSLTHSGIKQLENLLLNNNQISVIPEDLFKHIIIRTLDLSSNRIKEIPPRFLENPKTPQIINNLYLYDNEIEFVHSESFAGLPNLKTLPPPITNIKALMRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZU3</accession>
    <name>A0A6P8IZU3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116306751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572702.1">
        <property type="nucleotide sequence ID" value="XM_031716842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZU3"/>
    <dbReference type="FunCoup" id="A0A6P8IZU3">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="GeneID" id="116306751"/>
    <dbReference type="KEGG" id="aten:116306751"/>
    <dbReference type="InParanoid" id="A0A6P8IZU3"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF110">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031572702.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14486" checksum="5BCD384B59C56C0D" modified="2020-12-02" version="1">METTFEDALDMVCMDDVLPPASSPEPDSPQQKKKKARRRGPRLTGVSKQRRLANARERNRVHILNMNIQVLRELIPLPPQEKEPTKTEIIWMAAKYIALLGDMLDQEPFDFEECSVLSDLFLDAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0K4</accession>
    <name>A0A6P8J0K4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116307014</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116307014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573017.1">
        <property type="nucleotide sequence ID" value="XM_031717157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0K4"/>
    <dbReference type="GeneID" id="116307014"/>
    <dbReference type="KEGG" id="aten:116307014"/>
    <dbReference type="InParanoid" id="A0A6P8J0K4"/>
    <dbReference type="OrthoDB" id="5972940at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032736">
        <property type="entry name" value="Hinderin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28375">
        <property type="entry name" value="PROTEIN HINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28375:SF1">
        <property type="entry name" value="PROTEIN HINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15369">
        <property type="entry name" value="KIAA1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573017.1"/>
        </source>
    </evidence>
    <sequence length="982" mass="109298" checksum="D24FB432514EA398" modified="2020-12-02" version="1">MAAKTRRRFEDKTNVFWTKDPEVSDNQIVKVHIPGVSLDAALNIKQPMVKKPVKHRKPRIATLQQASGMSSNCLTSRGGVGMIRRKVNHEIDTIPTREDPTASGNVAQKKTSLKDLGPEDKKRVANLVKELAKVGEEREIALTQLTQERIAFEERLQILQEEYDSNIKEKLNLQSRFLELQGLLKKYNKHGTDKNKDTSSSGNISRTNHMTQTSPGLIPSPEDVPGNVRQSAGQTKSPCKTIKQSGLEDGSHNLIADSGCQFPSPTKMSRQSTPLPGKPEGDRSLVLPGNGIAGSEKGSASNNKGIVENDSVVTGNGTSSFDRSRSKRESAQSSKILPGKVTTGVPQIASHQEAAGLDLRQGSLSVPGSSAGNHVTRPAVLTEIPTSQQEVAHSVPGKAGNGALDQEIGNNLPSYHFLGNAPPSLRSQWPPVYRHPPPVSSEHDPPVYANRMFDVSVTRPDVLRQATVTTNRSQSDTSQSFSAELDAVYRLYCREYELQLQLQQQQLELQKQQLQLQQQLQQLEYFQQRQQQQRPTSSIEEMPKSSSKTVIRETPDPTPAPQPEAQPQWASSMSNLVPTPDETYESHRGQSSVSYHQDNEYRGDEDEGTEGDKDSRTIRRITSSKRPKANSSRERNVQSHEGSYTSTNHNRVSRSRDNPSMSHHSLQPSGERGFDESSRGVNKEIIKPEEASHFRFSLHSSSSLHPSQTQSIPHSTRLENQVDWTNATDFEFRQLQESKIREHYGLGQRSVHSTQVLLDPSEPRVTGARYNLYESATVAEPVGSITNKDHQVLQGYTGSSIDRHPHGTRTDRQYLAQQNRFDATAPDDISERELEQRTLQNFSLYENRANQFKGASCGAGFYGDNNHGDHHEDIEPWVSESSGFQRDASRSLELNYPPQIIDLVEELEDEPTIPPYSSKPNYTVYLSPPRQETAAQNGGLDSTDSGFSNLSREKSPMIYSHQGSENEADIEELSVLEDIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J119</accession>
    <name>A0A6P8J119_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein POC5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein of centriole 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116307203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POC5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573217.1">
        <property type="nucleotide sequence ID" value="XM_031717357.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J119">
        <property type="interactions" value="1769"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116307203"/>
    <dbReference type="InParanoid" id="A0A6P8J119"/>
    <dbReference type="OrthoDB" id="10064898at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033351">
        <property type="entry name" value="POC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="14">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="14">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031573217.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="58961" checksum="45F74430F5EA8047" modified="2020-12-02" version="1">MSSSSDNSLPYLPDNDSPGSSVSSSLQKEYEELLKYAVVTPKIHIAENIYERNSKAQPSRGVDNGGQSSEDSSKSSASFSSKPSNSDSSQSIYVEDTSNVVRDSVAGLPSISLMGQGSLARDSLLRDESAXATPNGREGGSXSSSNDASPSEESPSSDKSDESPIGRQRSPGIDADLARMEALLDSWCLDLKRNVLAELAQCKMGLFEKQKQIILQEKRRHXADRNKLLNEMESQKELLYTYEQSISHKDSIVANMTSALQRQRDKFELLKGFSQWKVKHNDENREAFTDKLSXKHYNHKLKAKAWSSWRQLIESQWKNRVERACQSKAQEVCVKLTEDYETKLEKTNHELEEARQEIAHLHAEREAYEETMKKAFMRGVCALNLEAMTMFREGEEGGRQTSFDSDQEDTPRSQAPVPSASSTGIPVGMPGPSSQSGVPYKPASQAGGRKITVRATGREDLKGAKGGAGLIGHQGPVSSILVQRHTSQPSGPSTLPPTRQQPPTTTSMRTTKSRPLPVKTVHTTPLKSDFPETXK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J122</accession>
    <name>A0A6P8J122_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 271-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116307207</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573222.1">
        <property type="nucleotide sequence ID" value="XM_031717362.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307207"/>
    <dbReference type="KEGG" id="aten:116307207"/>
    <dbReference type="InParanoid" id="A0A6P8J122"/>
    <dbReference type="OrthoDB" id="5984430at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
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        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
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    <feature type="domain" description="C2H2-type" evidence="13">
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="397"/>
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        <location>
            <begin position="425"/>
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            <begin position="630"/>
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        <location>
            <begin position="658"/>
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    <evidence type="ECO:0000256" key="12">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="13">
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    <sequence length="946" mass="109736" checksum="BB2F2C55E211B91B" modified="2020-12-02" version="1">MAEEDAVDPDWCGYECKSGQILFYYNKRTGEHRWEGGDYIFMSEXDKIDPDWCGYECKSGEILFYYNKTTGEHRWAGGEHEFKNDSSPSVSQEIQCAKTDDCGCTNGQTTQTKGKRVRQENRNSSKESGYLDEKDEESQPSKQRSLGEHVTETTGGEGDKKRRKSKNPNAKTNKCTYCNKGFEKKLGLEKHERIHTGVKPYECKYCKKAFAQKGDLKCHERIHTGVKPYKCSYCDKAFARQTNLKTHERIHTGVKPYKCTQCSKEFTRSDQLTSHKLIHAGVKSHKCTYCDKAFTQKCTLKEHERIHTGIKPYKCTYCDKAFTKLGNLKYHEXIHTGVKPHKCTYCDKAFTLKGNLKDHERIHTGVKPYNCTYCDKAFILRSTLKDHERSHTGVKPYKCTQCSKGFGLKCSLKNHERIHTGLKPYKCTYCDKAFARREHLKYHEGTHKGVKPYQSXMAEXEAVDPDWCGYECKSGXILFYXNKRTGEHRWEGGDYIFMSERDKIDPDWCGYECKSGEILFYYNKTTGEHRWAGGEHESKNDCNPLVSQEIQCAKTDNCGCTNGQQTTQSTGKRVRQENRNSSKESGYLDEADEESQPSKQRSLGEHVTETTGGEGDKIRRKRKNPNAKTNKCTYCNKGFKRKRDLQKHESIHTGVKPYKCTHCDKAFTHQSSLERHELIHTGVKAYKCTYCDKAFTTQDQLKSHERCHTLVKQNKCTYCSKEFLYQYDLKRHERIHTGVKPYNCSYCSKAFTLKSHLNDHERIHTGVKPHKCTYCSKAFTLKGNLKDHERIHTGVKPYKCTYCDKAFTQHGGLKRHESVHTGVKLYKCTYCDKKFRESGHLKSHERIHTGVKPYKCTYCNKAFSDPSSRKRHKRIHTGVKPYECTYCXKAFLERSNLNRHERIYTGVKSYECSYCKKSFKQQCILKVHENTHKDVKPYKCTHYLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J1S0</accession>
    <name>A0A6P8J1S0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19 20">Integrin alpha-9-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19 20" type="primary">LOC116307695</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18 19 20">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573856.1">
        <property type="nucleotide sequence ID" value="XM_031717996.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573864.1">
        <property type="nucleotide sequence ID" value="XM_031718004.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573872.1">
        <property type="nucleotide sequence ID" value="XM_031718012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J1S0"/>
    <dbReference type="GeneID" id="116307695"/>
    <dbReference type="KEGG" id="aten:116307695"/>
    <dbReference type="OrthoDB" id="5573735at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519134" evidence="13">
        <location>
            <begin position="21"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="423"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="476"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="630"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="775"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031573856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_031573864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_031573872.1"/>
        </source>
    </evidence>
    <sequence length="1033" mass="113121" checksum="2973DF59858A7354" modified="2020-12-02" version="1">MELMLIALLVIATVPWNLDAFNVDTSKAQIFSPPSGYKGSYFGYSVALHSYSTDKWLLVGAPLSNVSDLASSSSSLSLKNYGAIFKCKVPSSSPSCIYIPIDNTANEKRQGRLNNQPTQLEMETKQNQWLGAVLESTGKNGKVVTCAPRYAYRGEPPQDSSTFQYKWILGRCFEVETSLIRAKSTIIEPCLDKKKGNNYYGYCQSGFSAKITADKEPYIAMGAVGVSRWKGGVITYSPAFKTTTLSTQDQIDHGNYMGYSVTSGYFGLANKTGIAGGAPRAENIKGKVLIYQIEGQLTVSAALPQPKNIKMGSYFGSVLCSVDLNKDGYTDMLVGAPLYSDVGDEGRVFVYMNNKRGALNLMPDMDLTGDKVAEGRFGSSIASVGDLNKDGFEDVAIGAPYEGSGAVYIYHGTMTGIDPKHKQKIMGSEVQSSLSQFGQSITGGLDVDDNSYPDIAVGAFGSDQVVLFLTQEVLNVEAEVKLNVQRIVLENNETTCSESDNTLHKCLNVTVCFRNLETQRTDLNISYKVELDRDKGSDALKRMYFYKNDQKSFVASRQRLMPFKSQERVCLSPYTVHLREKDRIVDLLSVLTFDLSFDLADTPCGKVLCPVLNSYKSKLTRAVATFQKQCGSDICKPDLSVTGNLVIPGNLKEIHIGTVQEVTLVVEVKNKAGDAAYLSQVLISYPTTFDYIGPRASDLVRCTTSATRNGTETATCTVGNPLKGNSNKTFGIKFGTTELVNDFYITITAKSANEDLNKKDNEVKLKVGVKFEADLEVVGSSVPDEVIYEGKAKERSEIKTQRDIGPKIAQTIIVQNNGPSKVDGSEITINVPSQSLGDAKGYLLYMLQVELTGASGSCITKGVLNPENIPVGNITSESKESRRKRRDVTYLDCRRTTCKRFKCQLGLLLPGEKAEVTIRSRLWQSTLIRKNPGSVKIETVATVSIPDKRYTQPNTENDYVKIIINASPVSTGQAKQKTPWWVYFLAALGGVLLLAIAVGIMYKLNFFKRNRYAKDISEPVVDHAGSDNHASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3Q6</accession>
    <name>A0A6P8J3Q6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RPB5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116308381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574646.1">
        <property type="nucleotide sequence ID" value="XM_031718786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3Q6"/>
    <dbReference type="FunCoup" id="A0A6P8J3Q6">
        <property type="interactions" value="2482"/>
    </dbReference>
    <dbReference type="GeneID" id="116308381"/>
    <dbReference type="KEGG" id="aten:116308381"/>
    <dbReference type="InParanoid" id="A0A6P8J3Q6"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="8">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031574646.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24626" checksum="7F6F3E5CE9F05C35" modified="2020-12-02" version="1">MDDTELTYRFWRIRKTVMQMCHDRGYLVTQDELDQTLEQFKEQFGDRPSEGRPSRSDLSILVAHNDDPTDQMFVFFPEEPKVGIKTIKLYCQRMQEENINRAIIVVQLGMTPSAKQALVDMAPKYILEQFVEAELMVNITEHELVPEHVVMTPEEKQELLLRYKLKEHQLPRIQVGDPVARYFGLKRGQVVKIIRPSETAGRYITYRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J421</accession>
    <name>A0A6P8J421_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Failed axon connections homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116308485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574776.1">
        <property type="nucleotide sequence ID" value="XM_031718916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J421"/>
    <dbReference type="FunCoup" id="A0A6P8J421">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="GeneID" id="116308485"/>
    <dbReference type="KEGG" id="aten:116308485"/>
    <dbReference type="InParanoid" id="A0A6P8J421"/>
    <dbReference type="OrthoDB" id="5809458at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="189"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031574776.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31306" checksum="7BF5366B18DC5B6E" modified="2020-12-02" version="1">MAARSWSKVVRTFTRAKNTSSKLFNPQESVIVRQPAVATTVPSVSPFPLKLETYLRLANIPYKNRFGRAFSSKGKIPWMEYKDDKVADSNFCIRYLNEKFSVDLDAGLSAKGKGVGHAVLTMLEENTYWTIVYYRWIEIPHKTTNFLFPTASPWMKKLIAFGGQRRVKSYLHGHGIGRHTKDEIYSIACRDLASISAMLDNAPFLLGDKPTLVDTAAFGLLANIVWHDTESPLSAMIRKDFQNIEGYCQRIKEQAWPDWDDEIAKRKAIMYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4N2</accession>
    <name>A0A6P8J4N2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein 47-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116306954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572953.1">
        <property type="nucleotide sequence ID" value="XM_031717093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4N2"/>
    <dbReference type="FunCoup" id="A0A6P8J4N2">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="GeneID" id="116306954"/>
    <dbReference type="KEGG" id="aten:116306954"/>
    <dbReference type="InParanoid" id="A0A6P8J4N2"/>
    <dbReference type="OrthoDB" id="9858120at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056622">
        <property type="entry name" value="ARM_FBXO47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24467">
        <property type="entry name" value="ARM_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBXO47 ARM repeats region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031572953.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="51866" checksum="21BE6936EC0D748F" modified="2020-12-02" version="1">MASSICSYMKNVKPNYKTRKQKKTKDLLTKSSNPSTTYGYFSLLPKEMRFQVFSTIPLADLGNLALTSRPLRDCVLEFIESKQGLEKILPSIAVSEESASHIEEVVLFDDAMKYTEHFGDLVGEKVGFEDTESSPLRMLKDTHSLLCSQFGSEFAYSCYGSFLRAFIAGWENDEKLRAYNAIKGASCLDERIEKVLNSSPGTYPWFEKYIRVFCREIFLNKALDDQDRGFWLSTILKPWPLVFQARLLYILYGPFYRDTGLINWVVMSTCPTFYGVDDIEIRDLAEALTLLHKECEKTWNDDDIISVIEELSVITNDWCLENTAKLLVMCGEEITYAVLGSKAVNGRVHELAYLGYYVTQLAGRYDMGRSKSKKLESFMGLIKKILTAMPGYKNKVSFTMSLFNVWEENIITLTEAIQEDTEREGSPEEQEQALIETVHNLSKVAAFLLKESIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Y3</accession>
    <name>A0A6P8J4Y3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116308437</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">Golgi stack membrane</location>
            <topology evidence="12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_031574717.1">
        <property type="nucleotide sequence ID" value="XM_031718857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4Y3"/>
    <dbReference type="FunCoup" id="A0A6P8J4Y3">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="GeneID" id="116308437"/>
    <dbReference type="KEGG" id="aten:116308437"/>
    <dbReference type="InParanoid" id="A0A6P8J4Y3"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000006">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="66"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="203"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031574717.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="48908" checksum="DD3E9CD848358725" modified="2020-12-02" version="1">MYCLSIKHYKQFSLRTVLILGFIFLVFLWKSLDISIEFGKPLIKGDLYTSVVQKKSLRSNNERTVKLILLYTKFFGDFWNDHPSLGPLRPPILPGREAFDDCDYKCEITYEHDLLPLADAVGFHGPDIHLLSSNSLPNRTRPDQIWFYYILENPTNCNISSSLNRIFNWTMSYRQNSEIYIPYGKYSSLEPGDIVKEVDLTYKDLFVAWMASNCRETERNTYVGELQKFIPVDVYGHCGRFTCPLPRRSSSCRLLLKRYKFYLAFENGNCHDYITEKYWDNALENDIVPVVMGGADYSSPALAIPNSYMDVRDFDSPKDLAEYLIYLSQNDSAYMEYFQWKKKYKLVAPMRACPMCTALYNQELYDPPRTIVDLGKAWSKSDCWSLNLLNKSETQTKGISRTSESPIFIEPLDPTDTANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Z6</accession>
    <name>A0A6P8J4Z6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116308797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575146.1">
        <property type="nucleotide sequence ID" value="XM_031719286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308797"/>
    <dbReference type="KEGG" id="aten:116308797"/>
    <dbReference type="InParanoid" id="A0A6P8J4Z6"/>
    <dbReference type="OrthoDB" id="5962192at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="885"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="99"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="471"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="790"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1063"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031575146.1"/>
        </source>
    </evidence>
    <sequence length="1301" mass="147565" checksum="EA5E973DA731B88F" modified="2020-12-02" version="1">MAGLDKTWKYSLFMRNPKERAGVMSRLSFCWMNSIIKIGNRRALDPCDLYPLLDEDRSKELTEKLDTSWSQEIQDSYLKGREARLTRALIRILQWSEFALLSFSLFIGVACNILQPLLLGLLLSALLGNKNARGDPLVYVFSAGLCLSSLLRAVVLNQFHAKAQLLGMRWRSATTGLIYKKALRMRQKEMTKTSNETVLELVTRDCQRFDQVILKIGFLVEGSLEIVAITAFLWQLIDLPALTGMVFVVFLIGYYIGVWDVCIKMRSRIRHWLDRRMFIIKNIVSNLRCVKMNAWEGIYKEKALKYRRKEAQVLVQKSAILASFATLFYTSTTIAVFVSLTTLAVANVQLNVYNIFMTVALIRMIRLSSSSLYASAVSYISEYSASVSRIQAFLQIEEPSQLGTKNNKLKRSLKSRSFLDLTKNELSEFITRDDVNKIYSDIKKTSALEVPKYNEEFAETSDPENFPERFVSSSNLTCYWNGENKAPVLQNLTFKANAKELTLINGPPGCGKSSLLAAVLEELPAIEGTIAHEGKIAYVPQNPVIFTQSFRQNITFGRSFNPFRYQAVINACNLQKLLDKLPDGDLTIIGSQAIQLTDDQKARICLARAAFADADIYLLDDPLRLVNTKSAEKVFDKCICGLLSKRLRIMVSRQLQYVERADQILTMRGGTIINEVTSPMMGYRPAKLHGVGYGNDFKERVNDSLMRDEPEVMIPSDNHQNAQVVDAAVQTVTWTTYWDFFKIGLWSPLIPMCCLIFLGVQVALTAPDVWLLYIXHTSTNLMTSDETWYIYAALVATSFFLVIIRAAXFISTTLRSSDRLHDKLLEAILKGPADYFDNNSKHTILKCFXKDVASTDELLPGVFLDAMQGTLFNLSALLLPSFLNPFIFLFAIPLLLLFICYWNYYLKASRQIKXLGTNNCLPVFKHFTEMLNGIMVIRHYDVQEEFTEEVFRYQDTYSQACCAAVTCEAWIGLRIDLLSMVFLSIVVFGAHFMNLDAALTGISLVYTIQMACEMSIYGVKRCSDVDSYMTCVQKVMDLAKIKPEPGYNIRTRPHEPWPXAGRIHFDHVSLAYKTGGKKALKDLTISIYPREKIGIVGRNGTGKSSIIHALFRMPEIDGKIIIDDVDVKGMNLQRMRQGISVITKDPIIFCGNVRANVDPFNKHTDRQIWEVLEKTHIRAWVEALPKQLYQDMGECLSTLGPSEKQLFAIARALLHNAKILVMDEATAGVDYKTDXLIQELIRSKFRNTTIITIPYRLSTVIDYDRVMVLDNGHITEFDKPEKLLKKSDGFFAHLYNSQCAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J546</accession>
    <name>A0A6P8J546_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Protein white-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC116308845</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575210.1">
        <property type="nucleotide sequence ID" value="XM_031719350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575211.1">
        <property type="nucleotide sequence ID" value="XM_031719351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J546"/>
    <dbReference type="GeneID" id="116308845"/>
    <dbReference type="KEGG" id="aten:116308845"/>
    <dbReference type="OrthoDB" id="5984731at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="99"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031575210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031575211.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34365" checksum="D99222A26178A082" modified="2020-12-02" version="1">MAEVEPDHWASNANDTIDEGNGEETKTTEDADDSSDSSQEKTKMDGLSKPKASLISNEVVPEVASEPENPHAVSSLTGGGDNQKRATLSWHGVDVFAPIDRGSICRRLCRKTDPNEPRIKQILFDVNGKVEPGTLLAVMGASGAGKTTLMNVLAHRNIGNVKVMGSVMVNNTPVGLNINSISAYVQQEDLFIGTLTVREHLTFHALLRMDKHVSRADRLRRVEEVLLELGLVKCADTLIGIPGRMRGISGGEKKRLAFASEVLTDPSILFADEPTSGLDSFMAQNVVSTLQRLASQGRTIVCTIHQPSSEVYAMFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J645</accession>
    <name>A0A6P8J645_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116308847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031575217.1">
        <property type="nucleotide sequence ID" value="XM_031719357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J645"/>
    <dbReference type="FunCoup" id="A0A6P8J645">
        <property type="interactions" value="2454"/>
    </dbReference>
    <dbReference type="GeneID" id="116308847"/>
    <dbReference type="KEGG" id="aten:116308847"/>
    <dbReference type="InParanoid" id="A0A6P8J645"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01337">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575217.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24046" checksum="A4E46289CB7CC7C6" modified="2020-12-02" version="1">TLFFKPLHCLGSQRSTISPKGKKENQDPNQKFPGKTSKQPWSQKCTVSITCDNGWSGIPDVRFDEGLSSSDGGGGGDDDEDDISFYTLFVGQCEKYPAKECSPPPKTEFFSFRVKTGDHDVAEWSAVHINECLYVHVPNEEMQPGSKECFVSLLEYAEEQLNCTHVFVCLLKDRPDRTSMMRAFMFMGFQTVKPGHEMVPEDPNYVFLAYTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JCH0</accession>
    <name>A0A6P8JCH0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116308917</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031575298.1">
        <property type="nucleotide sequence ID" value="XM_031719438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308917"/>
    <dbReference type="KEGG" id="aten:116308917"/>
    <dbReference type="InParanoid" id="A0A6P8JCH0"/>
    <dbReference type="OrthoDB" id="5978053at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="14">
        <location>
            <begin position="46"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="13">
        <location>
            <begin position="286"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031575298.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49468" checksum="47AAD080F1205791" modified="2020-12-02" version="1">MPYRKIEDSIIHVVPNDYTVEDFIESRITAPGRENEDDGFFVSNMDKMIAKYHEWHDHLPDIKPFYAVKCNDDPILIRLLHKLGTGFDCASRKEIXTVLGVGIPSSEIIYAHSCKKKSSISFADKNDVKMMTFDSENELHKIKEACPDAKLLLRLRPKESKALHGFSCAKFGCTLSNCAHLLSVAKSLSLEVVGVSFHIGSGCYDATTFIEPVESAREVFDLAEQYDFKLSVLDVGGGFPGDDSEYHFGHMCNILKETLNKNFPPESGVKFIAEPGRFFASASYTLAAIITTKKTCVKENCKDEEYPVSFSKYEPKKGFMYYIDDGIASSFTESVWLPGYEYSKPFPLKESKGEPLFPSSIWGQTCASMDYVTKNCILPEMFAGDWLYFKNMGAYSSVHASGFNGYTTNKHKYHFIRQANWEKVSKYFKEFPVDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYN6</accession>
    <name>A0A6P8GYN6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL19m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L19, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116286302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548633.1">
        <property type="nucleotide sequence ID" value="XM_031692773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GYN6"/>
    <dbReference type="FunCoup" id="A0A6P8GYN6">
        <property type="interactions" value="2193"/>
    </dbReference>
    <dbReference type="GeneID" id="116286302"/>
    <dbReference type="KEGG" id="aten:116286302"/>
    <dbReference type="InParanoid" id="A0A6P8GYN6"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031548633.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="31854" checksum="8B306E63BB3C00BC" modified="2020-12-02" version="1">MAHRFRAKTGFLSPFVTEKYFNKIARRVLNIPWSTKDTSKGSAEASYEERKKKQITTQVTPELWFKQDASQVQVDSIYKTLPNAKKALLRETPEPRFLWKECDQTQQEFPSTPEEVGVDVMTYLEQRDCYERIKRLQVPEFCVGSIVAVTRADPYVPRGKVRFVGLCMAKNHWQNTLGATFTLRNVIDGEPMEVNFQLYSPNIQKIEVLKHEKRDKAALWYLRDYPPNNSSINETMEALPYTTEPSTFVQSKEESAKIEKWFDQVRKKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H056</accession>
    <name>A0A6P8H056_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116286392</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031548765.1">
        <property type="nucleotide sequence ID" value="XM_031692905.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031548766.1">
        <property type="nucleotide sequence ID" value="XM_031692906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H056"/>
    <dbReference type="GeneID" id="116286392"/>
    <dbReference type="KEGG" id="aten:116286392"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="53"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031548765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031548766.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43420" checksum="39BAD568A4E55F47" modified="2020-12-02" version="1">MNHLCNNTGNGTGGNGACPNNRDDGQTQASITEIMRITSIVSYVLILVLSSLGNSTIIATVIRNKSMQNKANVLIINMAVSDLLATLFALPRMLDVYITKSKVWKVPEVVAEGACKFSPFMREVSCAVSIFSMVAIAVDRFYAIVVPMHRKPRLLELKFLIPSTWVTALVTNALYLYAFQMKKENELLQCKNVLTLQQDRIFDTFRFVVFIAVPLQILVYLYIIIAIKMGRQAIPGATGQSFASNRRHQNKKIVILAVTIVAFFFISWTPYYVLLLMFIYNAWQVYRPSPNAMIVIFILQRVFTILTYASFAINPIICIVFSSNFRRHITRTFCRSHLPKTRTFTQRTTATNRTTSRPLSLHNLDISLGQVTGIENPTHEDDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1X2</accession>
    <name>A0A6P8H1X2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549648.1">
        <property type="nucleotide sequence ID" value="XM_031693788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1X2"/>
    <dbReference type="GeneID" id="116287148"/>
    <dbReference type="KEGG" id="aten:116287148"/>
    <dbReference type="InParanoid" id="A0A6P8H1X2"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08557">
        <property type="entry name" value="PI-PLCc_bacteria_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26178">
        <property type="entry name" value="PI-PLC_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027768939" evidence="1">
        <location>
            <begin position="25"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549648.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40720" checksum="3A53C187964D375E" modified="2020-12-02" version="1">MGGCWTFLQLLCVIASQFIATSFGLSCNGSPQYCGLRFNQFTFPATHNSFSRPQSTPFKLYGNKEVSDADCYARNQGDSVTKQLKHGIRSIDIDTCAKDTFDLLEGNYMIKAYTCHKVFYSDPVSAILEEIDAWMDANPNEVVVLSFTDKVQRWNNNEIAKDIKKKLEDLWAPTSQRRRRRNLMLNDAFMTTGEWPTLREAVQLNQRIFLFMHTKLTSHMGGITWAHDFTWIKQTNNNLKFQESDNCQNLIPLIDESCQTDEKLISVDMFVTRGLPVCTTERANACNPLLSQATDRCYYQRKEYTLTVNFLKIDFPDRNGNLGYKVLKKVARDINKRNVESYIGINFGRYTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H304</accession>
    <name>A0A6P8H304_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cathepsin K-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116287296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549821.1">
        <property type="nucleotide sequence ID" value="XM_031693961.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116287296"/>
    <dbReference type="InParanoid" id="A0A6P8H304"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028021641" evidence="7">
        <location>
            <begin position="18"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="264"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="351"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="11">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031549821.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="69537" checksum="F6DFD25F12D6B156" modified="2020-12-02" version="1">MLSLSIFVLVVVYLCFSGLLKNGRDTSGVYRRXIVEAHDRIYDSLLLPRRYHATGLVSLPFDEINEPFEAWFAGDMNMSRIDYYYGMDKTIQRGDVGKQGTLFKIVPMHSEIKPSNNDYVSCWYKPLPRWLSRSGQSVVPTNLSEFNISGVEIHRGHPCYKLQRKFTQYNKTNTYILYITAHAPHRPLRFEMIGYDDLLTSHYDHYVIDYITFEPWKINTTVFDVPGESLCRKRXRINSTYVMNPMAEFMHFNHAKDKEIDKLYDKYKKKHRKKYKTAKEHETRKHIYKHNMRFIYSKNRQNLKYKLXSNHLTDISDEEIRVQNGLLHDHTSRHPAAKHININISRALARVPQSLDWRDYGAVSHVHSQGMCGSCWTFSALGAVEGSVFLRTGKLVELSKQQLLDCTWPVGNHGCRGGFQDRTLRWIKRNGIATKRDYGQYLAQEGYCHCGKGNCTTVHINGFMHVKKHNPLLLKIALATHGPIASSVNADRKTFRFYSHGIYDDVKCRRNTNHAVITVGYGNEKGVSYWLIKNSWGHLWGENGYIKISARRNLCGTTSGSLIAIKKSNNMKEFPLEHLRKIPWKNDDGPKEEELEPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4Y9</accession>
    <name>A0A6P8H4Y9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 13">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116288727</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity. Interacts with CHODL. Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 13"/>
    <dbReference type="RefSeq" id="XP_031551419.1">
        <property type="nucleotide sequence ID" value="XM_031695559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4Y9"/>
    <dbReference type="FunCoup" id="A0A6P8H4Y9">
        <property type="interactions" value="971"/>
    </dbReference>
    <dbReference type="GeneID" id="116288727"/>
    <dbReference type="KEGG" id="aten:116288727"/>
    <dbReference type="InParanoid" id="A0A6P8H4Y9"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000004">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 13" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="14">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031551419.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37217" checksum="713920F7CED0768D" modified="2020-12-02" version="1">MGTQIKDVTIAADAPKTLLLDKHADFIFSYGKKKDTDYDYCMTEYLRMSGIYWGLTAMALMDRLDQLNRDEVLEFVKSCHHENGGFSASVNHDPHLLYTLSALQILVLYDALDTVDVKKIVEYVKKLQQPDGSFYADKWGEVDTRFSFCAIASLQILDHLDAIDVDKAVEYVVSCMNFDGGFGCRPGSESHAGQIYCCLGALSITNALHHVNVDMLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGKVHWIDKEKLITYILACQDNETGGFADRPGDMVDPFHTVFGLTGLSLLGSNEVEEINPVYCLPQKTINKLKSQPELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6G0</accession>
    <name>A0A6P8H6G0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC116289234</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="14"/>
    <dbReference type="RefSeq" id="XP_031551984.1">
        <property type="nucleotide sequence ID" value="XM_031696124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H6G0"/>
    <dbReference type="FunCoup" id="A0A6P8H6G0">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="GeneID" id="116289234"/>
    <dbReference type="KEGG" id="aten:116289234"/>
    <dbReference type="InParanoid" id="A0A6P8H6G0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004509">
        <property type="term" value="F:steroid 21-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11027">
        <property type="entry name" value="CYP17A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="10 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 22" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027619790" description="Steroid 21-hydroxylase" evidence="23">
        <location>
            <begin position="24"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_031551984.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56653" checksum="3718F6C219D07799" modified="2020-12-02" version="1">MLVEVLAFVVILVLLYVAVKSTGRPKGMPPGPTPLPIIGNFLEVIKWTSKNQMQIEFTKAAKKYGNIFTVDIPGDRTVVVNSASIAREACLTKKDDFAGRPYKFTWDYLTRGSIDIAIGDFTPTLILQRKLVHSALRNYNPHLVENVEKEADKLSKRLKSHAGNPVDPAHDFLLTTVNVICAMVYGEHYEIDDPEFLMILDYNTKMFRLLSAVHLLNIFPFLIHFPIKDSKDIELVRVNRDRLLDTKLHEHRETYQDGVIRDLTDALIKALQEAQKEDSKVRDLITENHVVMTMTDAFSGGLETTMTSLRWYCAYMVLNPDIQAKVHAELDDVVGRDVMPKWEDKSRLPYLEATIAETLRMSCVAALAVPHKASVDSTLAGYKIPKGTTLLLNIWAMHYDENEWKSPHLFDPTRFLDDEGKFLHGSGTKSYLPFGAGRRVCIGEALAKQELFIVISRLMHQFRIESPPGCPPPERIGYMGLVHMPKPYKICFKERVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H7R6</accession>
    <name>A0A6P8H7R6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caspase-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116289657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552464.1">
        <property type="nucleotide sequence ID" value="XM_031696604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289657"/>
    <dbReference type="KEGG" id="aten:116289657"/>
    <dbReference type="InParanoid" id="A0A6P8H7R6"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF41">
        <property type="entry name" value="CASPASE 14, APOPTOSIS-RELATED CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="146"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="4">
        <location>
            <begin position="332"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031552464.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45679" checksum="D60E26E536FC6337" modified="2020-12-02" version="1">MDRKESNKVAKEFCKAFLLERINEDQRAYERVLACHCNNFGGKRCECAPTEDISSIADTPMENRGTEINGDPNFYFSLKRIEKASMNGDEKDSFAKSKEDVLVDITGEGAFTMADIQTPSVAARIKDKKPLIKQPSFLEQVYDGLKDPYVILINNVNFKKRPAPRNGAEADTKNLRKFLKMAQFNTVKCYFDVKKDDMLKIFQDAQKNINLIRHDGLMCFIMSHGSSKGVETADNKYIKVDDITALFRGNQCPQFATKPKLFFIQACRGDDEDDGFNVPRGPNEXESDSESEEQLPVKMPSDSDFLIAYSTTKEKCSYRRYMHPGCDVYDASYENVSMGSWFIACLVDVFLAYSHEEDLLSMLTRVNKAMAELYTDMGQKQISCHLSILTKKVYFQNLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H842</accession>
    <name>A0A6P8H842_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 525-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116286285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031548610.1">
        <property type="nucleotide sequence ID" value="XM_031692750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H842"/>
    <dbReference type="GeneID" id="116286285"/>
    <dbReference type="KEGG" id="aten:116286285"/>
    <dbReference type="InParanoid" id="A0A6P8H842"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000385">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000787">
        <property type="entry name" value="Zinc finger protein 784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000345">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031548610.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30124" checksum="B9BD7F086AA70706" modified="2020-12-02" version="1">MILCSLVIRQHFEIKQQVRKCKCSFCCPAVNHSINEPIRRQETKSNIYDRIPPLISIASTVNNESIKNVNIPWSSRAELPKNSEPSKDDVMTAPMKEVESAHASSLNKPCGKQVTCSCSFCSKSFTSTRALELHVRRHSGLRPYPCKFCDKCFYQPSERAVHMRTHTGARPYRCPYCLKLFRYSGDLKQHINIHTGQRPYQCEICAKAFTNHSTLRQHKRIHTGERPYKCEECGKTYRYHSSLKQHLLAHAANKLKQKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8V0</accession>
    <name>A0A6P8H8V0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Radical S-adenosyl methionine and flavodoxin domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA wybutosine-synthesizing protein 1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA-yW-synthesizing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116286746</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031549187.1">
        <property type="nucleotide sequence ID" value="XM_031693327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8V0"/>
    <dbReference type="FunCoup" id="A0A6P8H8V0">
        <property type="interactions" value="2471"/>
    </dbReference>
    <dbReference type="GeneID" id="116286746"/>
    <dbReference type="KEGG" id="aten:116286746"/>
    <dbReference type="InParanoid" id="A0A6P8H8V0"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="21">
        <location>
            <begin position="95"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="22">
        <location>
            <begin position="388"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="259"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031549187.1"/>
        </source>
    </evidence>
    <sequence length="719" mass="81707" checksum="354C62CEB743D495" modified="2020-12-02" version="1">MATKDFCRNFQTSLFFSLIFITFLTITVKGDDNPDKTSVHTNEVSWSMIFKPVMGVVAGILGIWLWTTLKAKQDEEKLPKTRDPNQADKLTTSAIKIFYGTQTGTAKKFAEMLQELSTRQGTDCSVTSLKDYEPEDNLPNESCTCVFIVSTYTDGQPPEDAVWFCKWLEESSNDFRVQKSLLGGVKYAVFGLGNSLYKDNFNMVAKNIDQWMTALSAQPAVPLRLGDENHINSKHGGIEADFEAWTKELLATFKSTSSCECGSQETCCKDEKNPQPLLKDSDEDAMYESSTDEDNDDESDKNRKKDPKSSGMVDLEDLGPALRKMKKAKEMENGSLVNEPKEMVTTVIRESLTKQGYKIIGSHSGVKICRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWQMNEPEMIVDGAMQNHFNMIKQFRGVPGVKLEKFEEAMKIKHCALSLVGEPIMYPKINELIKLLHGHEISTFLVTNAQFPDAIKNLVPVTQLYVSVDASTKESLKKIDRPLFRDFWPRFLDSLKALSDKGQRTVYRLTLVKSWNTDELKSYADLVALGKPDFIEVKGVTYCGESKASTLTMANVPWHQEVVGFVQQLVALLPDYELACEHEHSNCLLIAHKKFNIDGDWHTWIDYSKFHELIRDYEDSEGKASFSSLDYMAKTPNWAVFGDEHRGFDPDETRWYRKNRKDISGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9K8</accession>
    <name>A0A6P8H9K8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lamin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551853.1">
        <property type="nucleotide sequence ID" value="XM_031695993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H9K8"/>
    <dbReference type="GeneID" id="116289105"/>
    <dbReference type="KEGG" id="aten:116289105"/>
    <dbReference type="InParanoid" id="A0A6P8H9K8"/>
    <dbReference type="OrthoDB" id="5969558at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551853.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="39892" checksum="3F748C2508ACFDF8" modified="2020-12-02" version="1">MHVELGSQQRYPCNSSRIRDMNDHEHEFLEDDKTPSTIEELKRRKAQLENENSDLSMKLQEGQRLKTKLQESRKDGKKLVHNREKLKNLKSERQETSHNVVGGYQKKVEDESEATARDEPPTDTAYKEEHHSITAPLITEIHALKLENSMLVKGKRKVEEQRDSVVQELAALNTKHDKLLGVCNRLESEIHRLSSLVVKSKSQTSEQEEGIEILKEQLRCYQEDIKSLQGELQSTKRSNEQMKTELNEARLVIRDMRRQPPSVQVYPAAAMVEPVYRTYDERGYRYGREPLGYAMMRTYSGECLMPMRDANLRRGTPSKKAFLTPDETAVVDNEVVDHSLASSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HAZ8</accession>
    <name>A0A6P8HAZ8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116290680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031553644.1">
        <property type="nucleotide sequence ID" value="XM_031697784.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HAZ8">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="GeneID" id="116290680"/>
    <dbReference type="KEGG" id="aten:116290680"/>
    <dbReference type="InParanoid" id="A0A6P8HAZ8"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17390">
        <property type="entry name" value="MFS_MFSD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="11"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031553644.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50205" checksum="09B9C61E7B32DAB4" modified="2020-12-02" version="1">MTFKITEHRTSIYCLYFIGFMDLFSVSMGLPLLTRRTRQLGASPSIVGLIGSIYGGIQLFSSPMMGKLSDTAGRRKILVISLLGTAMGYFSIGLADSLLLLALARIPVGIFKQTQGMCKACLADVTAAIERPKVFGNFNAICSLGFVVGPLIGGHLAMTQNXFFTVMTLQSAMFVFMAAFAAFVLKLQSDNKDIKKDKPVEIQNPEEKEKNDDHFEIHGSKYTDNFILKKEKDDKIQEANPVSPKENTFFSKLLHFLQFQSLGSMVDILMLRFVLGFSMILFRSNFTTMLEYRYQTTPKTNGYIMSYNGIISGTSGAFVGYLMSFYNHQDSKALFHFAIILTSCILFITYSPDLWVLLIFIIPLSFSTAISRVCITNLTLTRGHKDERGVILGVGNSLLSFARMLSPLIGGFALEFSVYGPGTISVIIASIGTAIAAFPMLEEKKKVEVKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBW0</accession>
    <name>A0A6P8HBW0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 UFM1-protein ligase 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031549985.1">
        <property type="nucleotide sequence ID" value="XM_031694125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBW0"/>
    <dbReference type="GeneID" id="116287445"/>
    <dbReference type="KEGG" id="aten:116287445"/>
    <dbReference type="InParanoid" id="A0A6P8HBW0"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549985.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17657" checksum="FF1D2686DBC3824E" modified="2020-12-02" version="1">ETSDFFNQFEVVSGPDLCEFMIKKLDKKKEKQLAIEHRAALQEQLRQEDEPAMALHLVTVLLFQHFTSVPIHAPGRCVPQIISFLASHLTPEQQETLTRYQSLVVKRLTGGPVTDESEPGEEEACEKSAGALLEEKLQEIKNMALNIKKSNNKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HCN6</accession>
    <name>A0A6P8HCN6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116287755</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116287755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550295.1">
        <property type="nucleotide sequence ID" value="XM_031694435.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116287755"/>
    <dbReference type="InParanoid" id="A0A6P8HCN6"/>
    <dbReference type="OrthoDB" id="5987889at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031550295.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33150" checksum="93FA865468FEEA81" modified="2020-12-02" version="1">MILHAAYAVRESPTSVIIIQSPDTDVLVLCVSHFSEIECRKLWFRTGLSDRQRYIPVHTIQQSLGERLCQCLPAFHALTGCNSTSSISHRGKKKLWIALKFSATHQITLSLFGQQPDLDDTLAEKTEAFIRDLYPNTKRSTSTMDELRYLMFCQQRKRRNEALPPTSDSLRQHMKRASYQTFIWRSSLIAMQDLQSXEGHGWEIEDGTLKPVYMTKDPAPRSLVELTTCNCKKSQCQGNCSCYNSGLSCTEACFCMRDETCNNPHSTAEQYYSDSDEGSDDDLEDDSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HD74</accession>
    <name>A0A6P8HD74_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein P19A11.02c-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116290156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553013.1">
        <property type="nucleotide sequence ID" value="XM_031697153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290156"/>
    <dbReference type="KEGG" id="aten:116290156"/>
    <dbReference type="InParanoid" id="A0A6P8HD74"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031553013.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25396" checksum="A7DEFCA56240002C" modified="2020-12-02" version="1">MVPDNHTLHVHFTNFSLYEYDXDCLQLYENKSRIFKSKQAFFGQKSPFTITATRDVMFVFRSDEENNSTGFRANYTMFKTPTTAPPKTTAYSTTTIKPTTEHITTQPTTTKQPTTKQPTTTEATTFPTTTNINSTTNETVQCNPTTAKNKSYNKDNIHPLKKTWFCDETWRIVVMIIPLVVFILIVLVIIDIFCRCRSKKASKSGTSGSRYVSLIFYTHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HD89</accession>
    <name>A0A6P8HD89_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hemicentin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116287946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550515.1">
        <property type="nucleotide sequence ID" value="XM_031694655.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116287946"/>
    <dbReference type="InParanoid" id="A0A6P8HD89"/>
    <dbReference type="OrthoDB" id="5990028at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000612">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028236273" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="115"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="210"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="303"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="398"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="493"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="594"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="707"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="793"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="893"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="8">
        <location>
            <position position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031550515.1"/>
        </source>
    </evidence>
    <sequence length="1142" mass="122440" checksum="913894D1B94D4B3B" modified="2020-12-02" version="1">MIKGLGIILGVLLLVSKQGDAVITTQPISQSQFEGFDVTFNCSATASRTLTFTWTKDSTNIASDSRHNVTSNNQSSTLVITGLVASDASNYSCVANDSGNISTSNNATLTVKSNPSILTHPNSQYIFENTNATLSCKATGNPVPSLSWKKEGTILTSSDRLIIQTSNGQSNLSIIKFNKTIDEGNYTCVAKSGNKSVTSNTASLTLKLAPKVTSHPANQTKIEGENATIACDVNGTPPIAVTWEKDDSAFNVSSDERFHYSNGGKQLDIIAVQTSDSGSYMCVADNGVRVKSYPGRLTVHTYPAILAHPNGTKEVTENDNITFTCAVGGKPSPSIQWLKNNATLNTTAHSKFNVSGDGRILTITGVVRSDEGNFSCNATNKVGSVVSSSAQLIVNYPPEFINIQPNGTKEVKENDNVTFTCAVGGNPSPSIQWMKNNATLDTTAPSRFDVFGDGRILTITGVVRSDEGNFSCNATNKVGSVVSSSAQLIVNYPSKILVPPTSKTVVERSNVSLTCYLEGKPVSNVTWLKDGHPIIAANDSRVSVTLPSSVNATSVKITIINVNRNDEGNYSCQAVNDVGNDTSSGALLKVNYPPRILVPPTNKTVVERSSVSLTCYLEGKPVSNVTWLKDGHPIIPANDNRISVXXPSSVSNTTATITITNVNRTDEGYYSCQALNDVGNDTSSGALLTVNYGVTIFVNPQPEKRIEGESVTFTCEVEGKPAPNVTWLVNDNPLTLETSRMNVSQPTTHDRTVVNLTINGLKRTDEGSYSCNVKNSYGEKNSTAAALTVNYPPKILVPPTNKTVVERSNVSLTCYLEGKPVSNVTWLKDGHPIIAANDSRVSVTLPSSVNKTSASITITNVSRTDEGYYSCQALNDVGNDTSSGALLTVNYPPKILVPPTSKTVVERSNVSLTCYLEGKPVSNVTWLRDGHPVIAANDNRISVSPPSSVSNTTATIAITNVNRTDEGNYSCQALNDVGNDTSSGALLTVNYPPRIFSISPQNETKHENHSMTFNCTLEGKPLANVTWMFNNTDIVPDGTKYHVSGTTSVEKGTASLTITDLHRSDQGXYTCRAQNXIGTATSPVSAFLXVLCKFICKNYFYTMLDEQLRNNRGGPISRDNLPXYVIQGLSVKCRINTDLTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HE78</accession>
    <name>A0A6P8HE78_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116290437</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116290437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553328.1">
        <property type="nucleotide sequence ID" value="XM_031697468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HE78"/>
    <dbReference type="GeneID" id="116290437"/>
    <dbReference type="KEGG" id="aten:116290437"/>
    <dbReference type="InParanoid" id="A0A6P8HE78"/>
    <dbReference type="OrthoDB" id="5976830at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031553328.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="68815" checksum="21BD6FF3C62487DB" modified="2020-12-02" version="1">MDSQYNFETYAIAGSSAIDLRRYWNTNARRIQRLIERGIEELGAAKVSIVVEVNLMKDETETTVWLRTKMLTVLESTDLDQRVSSQVEPISESLAKYTREGSGWTVTAIKGATISIARYVPTRGGSYVPLPTFIEGKKAIISVRNKDNRCFQWALRSALYPVNQNPFRTSKYPHDDLDWSDVEFPMEIRCIPDFEERNELAINVYGVREKTIVPLHVPCNRGERIHLFYHGEHYSWVKSPSRLFAMHSKDGHKRFYCDACLLPFKDLKALKKHDQICRGASAKNSAAIVRCDGEADEPVLYRGPNAARNFLTALEEEEEYIRQRLVHKKKAKLTKEQLEAYHAAQKCHVCELGVLKYGRRAKKAWDKDGAYLGEAHPTCGRYAKDGEKPGKPSTHCFHCGEPLEEDFYTDKVMDCCEITGEYKGAAHWKCRHRIDPNMEIPVFFHNLRGYDSHLLLQGVEGHEVKCIPNNKERYMSVTIGKLKFLDSQQFMADSLANLAKYNEDSPISDEYGAERKGVYPYEYMNCWERFEETQLPPQESFYITLNEAGISDAEYSYAQEVWVKYDCKNIGDYHDVYLLSDVVLLADVFQSFRKMAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HGW1</accession>
    <name>A0A6P8HGW1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116291189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554183.1">
        <property type="nucleotide sequence ID" value="XM_031698323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HGW1"/>
    <dbReference type="GeneID" id="116291189"/>
    <dbReference type="KEGG" id="aten:116291189"/>
    <dbReference type="InParanoid" id="A0A6P8HGW1"/>
    <dbReference type="OrthoDB" id="6019752at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ephrin_rec_like"/>
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    </dbReference>
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        <property type="entry name" value="HYR"/>
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        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
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    </dbReference>
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        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028125025" evidence="4">
        <location>
            <begin position="23"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="366"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554183.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="89094" checksum="08CD6C77ECB32789" modified="2020-12-02" version="1">MAMLGCLVSLIVLVQLFQVAFSCPCSWTTCRHQWRNDWRPSNPPQGACVNQRRDAHFIYTRHKSTGSCPSSRGCSHSSQWKKLCSCREVYSCPYNHWTRWTGNVPSGTCRKQSRLRSYNEAVRYVIRQNSCGGIKSRCGAAQYDYRTFCACRFAVCSLGQWSSWTDLSKPVSNDHCASQKRRRSYTFTWAYMPRRDNCNGVEPQSCPRDQEETREKVVTCSPLPRPPNGKWDREDCVVNSQVCTSYCRLQCNIRNGYEISGTDARRCQTNGQWSTPWNSYCKDVQAPTIVCPSPRVVGNDIGKNKARITLPTVVATDNDGKVPRVTNDVGAAVKDFEIKDTYHIVKYTAIDETGNNASCFWQVTVKDTERPTAVTCPDDIKVETNQNLIRVNWKYPTFVDNYDKPPLRISSNKNPGVLFPWGKHKVIYTAFDRANNNGSCEFFVEVGPVKCPLFDPPQHGTRACNKNVQSSNYEMFCNVQCKKGYAFADSTPQLYMCESNGIWKTMTNGVATPLANSEKKPWPDCAPEEAASAAKKEFTFYTGACIGDEGQALNQIRNNFLIAIRNTPLAKFLLCDISQGLDCVVNNVKVYCGSRSKRSGGSETQRIITFDFIMSDTHPSADHQILVEKLQKMLKELGDLEIYLKTKLPSLSNMPSLTVEAKQATAFCPAPKVKRILDGQGSEIERSICVECPIGTHYSNNTQSCNLCEVGNYQDNIGQTSCKPCPPGKLSIEQGATNVTQCYDACKPGEYAHVTTGGAVTCLACPIGSYQPKALSKSCLKCPQGKTTSRVGASALEDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIC9</accession>
    <name>A0A6P8HIC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C7orf57 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556144.1">
        <property type="nucleotide sequence ID" value="XM_031700284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIC9"/>
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        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="GeneID" id="116292936"/>
    <dbReference type="KEGG" id="aten:116292936"/>
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    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040247">
        <property type="entry name" value="DUF5524"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31097">
        <property type="entry name" value="SI:DKEY-276J7.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17662">
        <property type="entry name" value="DUF5524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031556144.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="37381" checksum="EA5FF7B1CF15C550" modified="2020-12-02" version="1">MPNPRISTQDWYYDAPNKKSTAKAKEPPPASQIPGLSNFIEEPNEMEERQFRRKWLRDTDSNYIKLAKGGGRKHLLDYREPPSEKPEEVGYPRVDWFDHYNPEPENVEEFSSAPPPVEMPRSKRMMPRTQPHRVLPEWYVHDRRDEEEKEPLNDLHVDQSGKKKNIISFDNMSAWEREAKDEANARNGRHVKLPPLHSKGKQEKSKASKVVQQFPKRYATRVPKMDSEPVDFRHLMSMGYQRDWFDDQNQKHVEEKRKLQVERQKNDQKASKQMREAIEMRKPKYNVTEDEDRHMFKLSRFQKVQPRVESFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIP0</accession>
    <name>A0A6P8HIP0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase delta subunit 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116289648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552455.1">
        <property type="nucleotide sequence ID" value="XM_031696595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HIP0"/>
    <dbReference type="FunCoup" id="A0A6P8HIP0">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="GeneID" id="116289648"/>
    <dbReference type="KEGG" id="aten:116289648"/>
    <dbReference type="InParanoid" id="A0A6P8HIP0"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031552455.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13020" checksum="43AF1F09B4B5C196" modified="2020-12-02" version="1">MSNKLITDTFPTVKKQKVIKQKPQSAKTQDKKAEVKKIDVGVSVQDEKTRLSLLKEFDLNSEYGPCIGISRLQRWERAEKFGLHPSQDIKDIITQHLDDETYTECIWKDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HIV7</accession>
    <name>A0A6P8HIV7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine dehydrogenase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555786.1">
        <property type="nucleotide sequence ID" value="XM_031699926.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HIV7">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116292581"/>
    <dbReference type="InParanoid" id="A0A6P8HIV7"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000008">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000769">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000004">
        <property type="entry name" value="Sarcosine dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF11">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="428"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="486"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="821"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555786.1"/>
        </source>
    </evidence>
    <sequence length="930" mass="104230" checksum="CA1E6E68DDDD0AD4" modified="2020-12-02" version="1">MLRIQRFLTYKTTPFYRPIIGLCRRTGIRYISTSTRDDVKAKVPYQNILQKEGDKANPKSLPKEADVVVIGGGSIGCSVLYHLACMGVTNTVLLEKDQLTAGTTWHSAGLLWRLRPSDQELELLAHTRNLARDVLENETGISTGWIENGGLFIANNKERLDEYKRLMTLGKAFGVESHVLSPEETKELYPLMNVNDLYGTLYSQGDGTIDPAGWALSLNRGATKRGAKVIENCRVTGITTDVDDFGMRRVMGVDTDSGHIKTKNVVNCSGVWSPYIGSLAGVNVPLCAMYHAYIVTERIEGIQNMPNVRDHDAAVYLKLQGDGLSVGGYEQNPVFWEKVKKDFAFGLFDLDWDVFSVHIEGACNRVPVIEQTGIKSTVCGPESFTADHKPLMGEVPELRGFYLGCGFNSAGIMLAGGCGRELARWIINGSPDLDLHGYDIRRFHSSMTDNQKWIWERSHESYAKNYAMVFPHDEPLASRNMRCDAFHKVLLDAGCVYQERHGWERPGWFNISQQPEVKEYDYYGCYDKKKHEDYLYNELLSQEYTFDFPPHHDIIEQEAKACRTSAAVFNMSYFAKYYITGQDAQQAVDWIFTANMQKPAGSTTYTCMTNKDGGVEADLTVSVLEDGDGSSVVRPQFDGDGFYVAIGGGVGQHSWSHINNILAEKKFDVKIQDHTNDMGLLSVQGPKSLEILQSLTTTDLSTEAIPFSTHKVINIAGHDVRVIRLTFVGELGLELHIPRDSCVPVYHAVMSAGENYGIANAGYRAIDSLSAEKGYKHWHQDLRHDDTPLEAGLGFTCKLKTDTPFLGREALEKQKEEGLKKKLVCFTIDQPKALIGLEVIHRNDEVVGFIRRGDFGFAINKSIAYGYVKDPSGKTVNNNYLKEGSYTLESMGEVFPAEIHLKAXFDPKNLRIKGQYEAERITERKYMMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJJ1</accession>
    <name>A0A6P8HJJ1_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase RNF181</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RING finger protein 181</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116293285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNF181 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031556549.1">
        <property type="nucleotide sequence ID" value="XM_031700689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJJ1"/>
    <dbReference type="FunCoup" id="A0A6P8HJJ1">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="GeneID" id="116293285"/>
    <dbReference type="KEGG" id="aten:116293285"/>
    <dbReference type="InParanoid" id="A0A6P8HJJ1"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16669">
        <property type="entry name" value="RING-H2_RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000022">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF160">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031556549.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15731" checksum="875EC1A27DEDF6EE" modified="2020-12-02" version="1">MASYFDEHASTDRASHPNFLLELASAGFDNIGSPPASNEAINNLVVVTITRNHLKDDSTSSCPICLAEYEENEKVKQMPCEHMFHSGCILPWLEKTNSCPVCRYELPTDNEEYEELKKLKGKEEGRQHRVQTLHASMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HJX8</accession>
    <name>A0A6P8HJX8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116290055</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116290055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031552895.1">
        <property type="nucleotide sequence ID" value="XM_031697035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HJX8"/>
    <dbReference type="GeneID" id="116290055"/>
    <dbReference type="KEGG" id="aten:116290055"/>
    <dbReference type="InParanoid" id="A0A6P8HJX8"/>
    <dbReference type="OrthoDB" id="5966955at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031964">
        <property type="entry name" value="CARD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF37">
        <property type="entry name" value="MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16739">
        <property type="entry name" value="CARD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CARD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031552895.1"/>
        </source>
    </evidence>
    <sequence length="951" mass="107301" checksum="3E754CDFE57A150B" modified="2020-12-02" version="1">MEQGIRDLLKEHYQDMMRDITEPHILANGISVLTPVDLERIEAETRERGASTGVFELLNRLQKRGPQAFPQLIEALRKSKYDEIANKLARIAESRKLYRNRCNRQTGNNTEVVARGPWAGPKPPQTERSLSYPVQQQTSLNHQDSTEELHASRSTPVLTHINIPRPEDLTQHEEKPQQLKYKGKDTLLKDIPSSLKDKVVNMLSVEDALGKDWKGIAGALQLTAEEQGQIKSCSKISPMEELFNQMLHKGYCVVDLIKMLKKIYRFDVIGEISKAGYYSQDLEEGVESPTQGADDLAAKKLDKGLPLPKQVSEDSSMEEEKTDAVSPTAISPLSPTDFTMEQKERKGFSPTASPLSPTDFTMEEKKRDDISPTASPLSPTRSDNSTVKELDKKKVEKGGDVRCLTQGLPLPTKVPVFGSDDNTKQELDMKKGSSIAGQSSENEDAEFGSDKKGDVSNCAESFPSPTQVSEFNSLDEKLDEKKEAHFSQEIENAKKEEQDQSEPLTDMTPFEEEVFFPDTLQSKAIFITCEKYKKMSNLPHLNKETKKLCRELEDGNWEVFPLKDNNSVKMKSELDLKLHNLSKTDVCLVYLAGHTLQINGENYLLPIDVESNLAAADIVDSCLNINSLVNQLSKKALMALIIVDGGHYNQEKFECPFVLTGLTSIIPPPNTVIAFPCQPGYIRPKEETLSYLKALVDIIKEKKHLALTDLFELVRDTLKDCQSLPVEFSLSSSLLPIYLNTNEDDEGITIWKPDEKTPRRAIVFCDHSLHKKTVLTSAGHLESALKQLDWQVQMCANLKPEQIKMKIRQSLKRLQGMNVFMLYFIGYVTKDKHSIGQENYELNIFAHSQKLSIQWVVNIMTEYVTGPKILVVDDPSVPVRHPLSTMTPLPQEVLTCLPNGNRERIREEENSFTLLFAQNLSKSRQYALKTVITNTARTWKYHHVNSSLFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK41</accession>
    <name>A0A6P8HK41_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116290111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552960.1">
        <property type="nucleotide sequence ID" value="XM_031697100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK41"/>
    <dbReference type="GeneID" id="116290111"/>
    <dbReference type="KEGG" id="aten:116290111"/>
    <dbReference type="InParanoid" id="A0A6P8HK41"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031552960.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33763" checksum="D472833B9D06711C" modified="2020-12-02" version="1">MNRRHWRGRARMTGTNVRGHNGLAGAGDHKVLVDLIILSKKMSSCFVFQVEVNPLTYFENVQKHYQLNRKVILNLRGTKPKCQSWNMRYTTQNAQYTPSCNKIGVAVGLLQPPLYHSDFPSAINFGSIGMATGHEITHGFDASGAMYNKDGNVKLWWTKDTLQKFEKKTKCMEKQYSKFLVYGHHLNGKQTLNENIADNGGLRIAYEAYSKWLQTQGPDLTLPTISLTPKQLFFLSFSQTWCLKNTKSASIYALFTDEHSPSKARVNYVLSNMKEFSDAFKCAKGSPMNPEKKCIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HLL3</accession>
    <name>A0A6P8HLL3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116290578</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031553510.1">
        <property type="nucleotide sequence ID" value="XM_031697650.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HLL3">
        <property type="interactions" value="1907"/>
    </dbReference>
    <dbReference type="GeneID" id="116290578"/>
    <dbReference type="KEGG" id="aten:116290578"/>
    <dbReference type="InParanoid" id="A0A6P8HLL3"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="394"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="705"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="913"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1145"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031553510.1"/>
        </source>
    </evidence>
    <sequence length="1322" mass="148893" checksum="F684B52DCFE8E06D" modified="2020-12-02" version="1">MRNLEVLRCIPVTEIDGSEGSSCLTVDCDTGSVYTATATNIIGFNPSTQQVESNVSLVTDEYLPDDGSGQVIGIQHLPDIQSVCVATLAGDVILCNTNTEELECVGSVDSGITCMSWSPDQELVVFSTGDNTLIMMTREFDPITELSIHTTEFGEEKPINVGWGKKETQFHGSVGKPTAEKLKPVIVNPAFEWDDKQCRISWRGDGQYFVVSAIETDTGARKLRVWNREGVLMTSSEDVDGLESPLCWKPSGSLIGSTQRKPHRHEVVFFERNGLRHGEFTLPFDRMEVKVNEMQWNSDSSVLAVWLEDMPAKDNFPKSYVQLWTVNNYHWYLKQEICFSATQEDKVACFVWDPEFPLKLHVMCSGGQYICYEWCWSTTYSQGNSSNNLSTVAVIDGTRLLLTPMRHMVVPPPMAAQTVTMPTAVQAVTFAPPPLCNDMAVLLSDGSLALVEGSHKDEFKPSGDLPRVIGTQKMDFDGVSGLWKGPLFLHHLTWWKEKQLVAVGWDVMEQKDVLCQMDINKEEAGKAVITVSHSQPTEEPVLRMYSNPDTGSLVIQSSNGNIWKYASEVNGIHLSPLLSGKGDPICLPQPCVQLQTATIGDEEIVLGLTEHGRLYAXDKEVATNCTSFAVHDEFLILTTHAHTCRCISLLKSSKGLPVLVEDKPYPMDENVRRVERGSRIVVAVRQDTKLVLQMPRGNLETIHPRALVLSFLQKCLDNLQYKNAFVTMRRHRINLNLIYDHNPKLFMDNVETFVRQVESVNFINLFLSDLKEEDVTTKMYSDYYDTSKTGTADEKTKVDXICDAIRAALQTIGPDRYILSILTSYVKXTNPELDTVLHIIRHLKDKPIEGDKCVTSEEALKYVIFLVDVNQMYDVALGMYDFQLVLMVAEKSQKDPKEYLPFLNKLRTMETNYQRYTIDKYLKRYSKAIQHLSKCGTKHFNELHSLVEEKCLFKEALGLFPKSSEQHKAIAVSYGEHLITKKQYEQAGIVLARCGAHEQAMDAFQKKGNWQQVFCMAAILGLSQQKKIEIARSLAGYLKGHHRHAEAARILEDYALDSEEAIVSLIEGSLWDEALRLIYKYSRLDIIETHLKVALKEGYSTQCDSIEQNMETFTKYKTRLQVVRETKERERLEILESGTLRDDTDADIYSDTSSMTGVSGYGSSVGSKGTRSTGRSSKNRRKLERKKYSLKEGSKNEDLALMYELAEIITKTDKCKEDISALLRALSLFDFDDEASILQKEFAKLDSLIEKSLPEIWPPNAPQEAQPALSMVTGPGATVNSIIAAMNTGNNTTQQAKKDDPEIPKMPVIRKDFQWQMDQYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HM40</accession>
    <name>A0A6P8HM40_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557424.1">
        <property type="nucleotide sequence ID" value="XM_031701564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HM40"/>
    <dbReference type="GeneID" id="116294042"/>
    <dbReference type="KEGG" id="aten:116294042"/>
    <dbReference type="InParanoid" id="A0A6P8HM40"/>
    <dbReference type="OrthoDB" id="5948373at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557424.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16037" checksum="EDBC5CB19D36354A" modified="2020-12-02" version="1">MQRSEATRAEYCRFMSSLSRDMLLFLDESAKDTRKLQRTMGHFFPGYAPVLEGHFVRKDRYSVLAAMDVDGIVATHTVQNAFSTQDFNFAIEFMIAPFIGNFSLREKRSVVILDNCRIHDSDYFINIIRERGGIVVFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMB7</accession>
    <name>A0A6P8HMB7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 3A2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116294106</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557494.1">
        <property type="nucleotide sequence ID" value="XM_031701634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294106"/>
    <dbReference type="KEGG" id="aten:116294106"/>
    <dbReference type="InParanoid" id="A0A6P8HMB7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031557494.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58180" checksum="56267864CEF29143" modified="2020-12-02" version="1">MEFVSSCVXSVSSHFGTLVIGLAVMVLIYWYGTRRARVLESAFPGMPGPKPLPFIGNXLDLIAAKGQXHVHFDRYYKKYGRLFSVSFFGSPGLVVGDPEMIKDILVKNFECFHDRPEMFTLPEPLDKAINIVKGESWRRIRNTLSPTFSAFKLKGMARLMNMSCDTLMKKAEDVAQXGGSFDIVRHQQALTLDIIMSTMFGIQTDYQNNPNDPIMQRALAAMKPSVFMQXMGNIVLPMLPFGRKFLTSKAGGKIFFKEMLELKNLXQDVVDVKRRGESNRKDLLDLILNSTSHDSTDKKKLTDDEVVAQCVVFLLGGYETXSTTLALVCYHLATNPRVQERLQSEIDTVWTDVDKMPSYETLHELPYLDMVISETLRLCPPGLVLLRQCNKECVIKGTKIPKGAIILIPSYSMHRDPNFFPDPETFDPERFSDEAKHSRDPYVYQPFGHGPRXCIGMRFAQMEIKLVXVRLLKNYSFVVTKDTKIPPTIESXATLTVTEDITLGVRKREQYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HMY1</accession>
    <name>A0A6P8HMY1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116294297</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116294297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031557724.1">
        <property type="nucleotide sequence ID" value="XM_031701864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HMY1"/>
    <dbReference type="GeneID" id="116294297"/>
    <dbReference type="KEGG" id="aten:116294297"/>
    <dbReference type="InParanoid" id="A0A6P8HMY1"/>
    <dbReference type="OrthoDB" id="7249367at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333:SF5">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031557724.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22953" checksum="4AFE1FBAFDAB0304" modified="2020-12-02" version="1">MAARFVQVLLRKNTVINFYFSRQLTNKTRVFQLKATLPYLSVFKRREFSSNSPENEQNSGRNEKENLENEDKGQIKGTVGTVITQGPFGWLSKKLHMVLLKAFFDPGFNEEEFLRGAKQALIVTSEILAERRFQDMSKICPPKFVDLIQEALKSKDPGPAIRAVDIIMAKIKKIQLGFTEEQKKQVEIDVTFVCHPKDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HN64</accession>
    <name>A0A6P8HN64_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger C2HC domain-containing protein 1C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116291115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554097.1">
        <property type="nucleotide sequence ID" value="XM_031698237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291115"/>
    <dbReference type="KEGG" id="aten:116291115"/>
    <dbReference type="InParanoid" id="A0A6P8HN64"/>
    <dbReference type="OrthoDB" id="10255185at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026104">
        <property type="entry name" value="ZNF_C2HC_dom_1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14649">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14649:SF1">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="8">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031554097.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="72658" checksum="A87B019A57A7DF76" modified="2020-12-02" version="1">MAHPSVYERQSAHSFQQSLQMPETYAPISTVQGMSTRDKKPRLSRLELMKQNYEKKRQKDVQEKLTEIRAQRARADSGKDHSGGTVRAFFAERRAMEASKRGQQDPSSLPPIGTHFKKMKSNNQGPVVPRSSQKKENKPVIPAENVTAIHGVHSTGNRGMVKYYXKKSKGVDKQNPLPPLQRRPSNPSNHKPPTPNRRYETQNTLKSEDEAFILNHSNVEQENIVADKDMVYVPRPPKNPKPSKTNARAAKPVLVDDNEERADEEDNDGWSLYSDEPQPNLSKVKALRMKRLSQKKLSVGNSKPEKPTEFQKWQMQQDEERRERLENHRKQNQHIDDSDNEQKATLSMRERELLEKIKAEQDKLSHIKRMQQELEEQEKLERENTITPQIPNENKRKMAVKEEKSFQYAQKRIDKTPTPVKKVSPVIPAQEETQLQFPEAPKKSKPKPKPQIIQQEQDSDEHELEPKDNFVHFYEQAGEEAEQVEVDLTPCSICGRNFATERLSKHQVVCRKNSNKMRKKFDTRKQRVAGMEHENYVLSGKYKEETPKAKKADWRVQHENFVKTIRYAKGASSEPPPVIENPHYVACPYCERKFNPETAERHIPRCKDIKARPAPPPKKDRHRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPK7</accession>
    <name>A0A6P8HPK7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC116291572</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116291572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554605.1">
        <property type="nucleotide sequence ID" value="XM_031698745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HPK7"/>
    <dbReference type="GeneID" id="116291572"/>
    <dbReference type="KEGG" id="aten:116291572"/>
    <dbReference type="InParanoid" id="A0A6P8HPK7"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027799919" evidence="6">
        <location>
            <begin position="22"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031554605.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45463" checksum="3081369EE3594826" modified="2020-12-02" version="1">MDRNLVLLAFLILSFLTPMQTQSSWLKESFPNPLKDTKKCGRGGVMSWICDPDQVIPYKEANILEEMLQFVGTKTKSGCSIDPQRPGFQIGVAVMNKMAVPSEMSKEEVAQDFARHLHNEWGVGSAGCDDGVLLLLSIKDRQIYVSTGRTAKERLTDDQIDIIIDEMKPILVNKQYGKALQLAADRMHQVFDGKILRSKNYFAIICILGFLAFFLGILIYKIYQSKQYESCQEKLNRIERERNAAKESKKYVSASCPICLEDFTPEMRTRLLLCGHKYCEPCLKRWLETNSTCPICRQSTNRRENENKDEDSASSGTLDFFPELTFRLLNLQRQYPTFITEDLIHHWTSQQFQGSFVDDSLFTVMRPIASSSGTTGSFGSTGGFGGGFGGGFGGGGSTSGGGKGGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPT7</accession>
    <name>A0A6P8HPT7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CSC1-like protein ERD4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116293769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557098.1">
        <property type="nucleotide sequence ID" value="XM_031701238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116293769"/>
    <dbReference type="KEGG" id="aten:116293769"/>
    <dbReference type="InParanoid" id="A0A6P8HPT7"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="35"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="202"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="364"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031557098.1"/>
        </source>
    </evidence>
    <sequence length="752" mass="85718" checksum="F0F068BE193107AC" modified="2020-12-02" version="1">MIPTMELSGNISTIAPTSHPNRSAGSKPHETSVTSFLVSLGINGLIAIIALLLFSLLRTKLKYIYTPRLLLLDTRFPLGKLPRSLVSWFIPALMAKDDDVFNYAGIDALVYIRFMRLCVKISFVLLPYGLAVLLPLNVYGGVGLAGLSKLTMSNLKENSSKMWAHFVAVWVYTLVIFYMLYEEWRVFVVYRQEYLAKGLDHQYAVLLRDLPKRLRKEENMKTYVDELFPSQVEDVAVVEDLRRWDKMISIHDELVLKLEKAKFVFEKTGKRPSHRSNQGHSIGDSITYYEKRLEDLQVKLEAELHKKHSVLPCSFVIFKSLKFATESLLRKSAFRKKGNSMPAPDSNDVIWDNLMLIPAKRKFRALVITLIVMLTVMFYFIPVGIVSSLIALQNLERKFPFLSHLESLPPVVXSFIEGFLSGLALLIFFAILPMFMRFLSSKQGFASMSQAEISTLKKLFIFKVINQFLFLTAGSALNKLKEMSNDPSLIPRYLSTTLPSQSTFFISYLMLCSFTVYPIELLRPFPLLFVAFKRKFFTLTPREDREIWRPPPAAYDALFADHLLILIIGLCYSVMAPIVSIFVLLYFVFGYVVWMYQLLCVYIPTHSSGGLMWPAIFNRIIVCLMVFHLVMTGIFGLKKMVVMPILLAPLPFLALGFLVYMNRSFSHSCNFLSHEISNTLPEASPRILQTVTQSYIRNHSLPEWNGLSTNATSRNITGYEEIPTASERSPLLSPIDVRTSSDPGHNEGHFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HR37</accession>
    <name>A0A6P8HR37_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116292049</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116292049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031555147.1">
        <property type="nucleotide sequence ID" value="XM_031699287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116292049"/>
    <dbReference type="KEGG" id="aten:116292049"/>
    <dbReference type="InParanoid" id="A0A6P8HR37"/>
    <dbReference type="OrthoDB" id="5989982at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028159657" evidence="1">
        <location>
            <begin position="25"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555147.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="59258" checksum="68404FA4510CECB0" modified="2020-12-02" version="1">MPGHHTFVLSLCFILTTPRCPSWANVKTRGLSLRGTTILVPLNISFQKWDCTRLFFAILHSNAIGKDLDSGVKKAVNDLRLIRNEVFGHLSSGKLTEHKFQTSMNTVKTAFATLHLDTADIEEVRNQXTFPIEELRVTQELLEKEKMRNEEPEAFCVLPPKPSHEVSYREKETKNILQEMEKLXNTKPNEITVIYLSGNPGCGKSEVARQIGEKVFDDVPDKETEVKFVFTLNASSIDRLIESYVEFAVSLKCDENSTTNIGTSTDLSQEDKLFHLKRLVAPKLRKYSSWLLIVDNVTDLKSVFRYLLEAGEKTDGKGQILVTTQDSRSIPDDSYTYHISLSRGMNLDEAMGTLLVISDMAADDEVTTQVAKTLDLQPLALACAATYMKCVRKTTPRFSWQQYLQKLEQGKREATEGXYKKISRXYTQTMTAAVKLAIERELAEDAVMLHAFKFLSAMAPETIPLEYIVQYVTRSMPDEDKELVAANVTSSSLILSFEGQSQEICVHQVVHACLNTILRQQSMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRE4</accession>
    <name>A0A6P8HRE4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116292139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555252.1">
        <property type="nucleotide sequence ID" value="XM_031699392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRE4"/>
    <dbReference type="FunCoup" id="A0A6P8HRE4">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="GeneID" id="116292139"/>
    <dbReference type="KEGG" id="aten:116292139"/>
    <dbReference type="InParanoid" id="A0A6P8HRE4"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031555252.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19902" checksum="F5BFCAD908DE724C" modified="2020-12-02" version="1">MVGETKANPMKDLRISKLVLNVCVGESGDRLTRAAKVLEQLTGQQPVFSKARYTVRSFGIRRNEKISVHCTVRGPKAEEILEKGLKVKEYELPRGCFSETGNFGFGIQEHIDLGIKYDPSIGIYGMDFYIVLGRPGMNISKRRRARSRVGAPHRLKKDDAMKWFQQKYDGIILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HRG4</accession>
    <name>A0A6P8HRG4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hexosyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116295325</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Golgi apparatus membrane</location>
            <topology evidence="2 15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_031558969.1">
        <property type="nucleotide sequence ID" value="XM_031703109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HRG4"/>
    <dbReference type="FunCoup" id="A0A6P8HRG4">
        <property type="interactions" value="932"/>
    </dbReference>
    <dbReference type="GeneID" id="116295325"/>
    <dbReference type="KEGG" id="aten:116295325"/>
    <dbReference type="InParanoid" id="A0A6P8HRG4"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047220">
        <property type="term" value="F:galactosylxylosylprotein 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000018">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031558969.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41420" checksum="87B583FAC90769CD" modified="2020-12-02" version="1">MVSCRRLILKYALFKPLRALFALFVIVVFLVIILTGDPDLDRYKIKKFQRDEKAVDKGTFESKLKELEPQKDQTDNTKPPKTSSFLFIMILTSPKGTERRDAIRNTWLKLDNSGQYMAKFIIGGKSLTRSERGMLEAENDNYEDLVIIPDMKDGYHELTNKVLQGFRWIDQHIDCSYVLKADDDSFVRLDAVLSELEGQTEEAKDPLYWGFFRGNANVKRRGQWAEKKWVLCDHYLPYANGGGYILSSKLINFISKNWEFFQLYNSEDVSVGTWLAPLKVHRLHDTRFDTEYRSRGCNNLHIVSHKQSIQDMYSKYESLQKTGKLCEEEEEIRNSFEYDWKVPPSQCCKRQSGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSK0</accession>
    <name>A0A6P8HSK0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleolin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558183.1">
        <property type="nucleotide sequence ID" value="XM_031702323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSK0"/>
    <dbReference type="GeneID" id="116294677"/>
    <dbReference type="KEGG" id="aten:116294677"/>
    <dbReference type="InParanoid" id="A0A6P8HSK0"/>
    <dbReference type="OrthoDB" id="5990665at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028444832" evidence="2">
        <location>
            <begin position="26"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558183.1"/>
        </source>
    </evidence>
    <sequence length="858" mass="91087" checksum="0DD0995C083348DE" modified="2020-12-02" version="1">MWPKHFVAVCLVATVVFAFTGPSDAAPTKGCKKTFTSLSQEAGLEAQALTDPDEDKVFHANSIDEITLMKKKSKVMEKRSDDNDCEGEDVENGAKKGNVVHQTVKPIPKSGIIKLDTNKPDKFVESIQIDANENSDKKVKKSSATGFIDPLVVQQKQRIQTLQSSIHKNLVKLFHHLKHTHPLNTLDDQKEVAQAKEALIADAKRMTALNHERSPAENFLSGLSNNTLISKMLKNKNKPNIVSLDNPLGNATKVNTSSSEAKAGSKEDSSFEVKTSGEAEPHGNEGSSNVEIKISGDVKPSGNNSKNIEVKNDDHSSFSAEEGKKASSQGSSGTEINSSGNLDSIDLAMKSSNDKPEENANKVKKLDNNKFTVSENDSSSNPNETAKLGKFSLDKKEENVTKLKVKEVKEKESDENPNIKHDPYAEIAASPDDPKMPPNVKLPKEGPYIPVGIPKNDDDDDDEKETEKEKDRGRGGGGGGGGGGGGARGGGGGAPFIPPPGDFAGQSEAPGQNDLSMEGNVNPDLADKGILNSFRTEAIQAQLQDQIQQQALEGQMMHGMNRMMGRGRMASAFGGGSLDGLGAVGGMGGMHGMGGMGMGAMGGMGAMGGMGAMGGMGAMGGMGGMGGMGGMAAGMDGIDGPRMGAMGGIGGMNDMPGGMGGMAGGMPGGMGGMEGVGGMGSMGSMGFARSMDGYGGMNGMNGMGRMPDMAGDMDFDEGAYGRRDFMPEEPPSYGGQYGYDESPRYPSMMEETGVSRNTVPARYPGADEIKRSRRPMYNPRYFNDDDDDEDDGPEGDYPEAVAATQRDRAPEPSRYEDLQANDYDPDEEYDSEDERKTRIAKVEKLSKIKTKSSKKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HT92</accession>
    <name>A0A6P8HT92_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium-regulated heat stable protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116295068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558646.1">
        <property type="nucleotide sequence ID" value="XM_031702786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HT92"/>
    <dbReference type="FunCoup" id="A0A6P8HT92">
        <property type="interactions" value="819"/>
    </dbReference>
    <dbReference type="GeneID" id="116295068"/>
    <dbReference type="KEGG" id="aten:116295068"/>
    <dbReference type="InParanoid" id="A0A6P8HT92"/>
    <dbReference type="OrthoDB" id="448492at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000086">
        <property type="entry name" value="Cold shock domain-containing protein C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052069">
        <property type="entry name" value="Ca-reg_mRNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962">
        <property type="entry name" value="CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12962:SF1">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN CG9705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558646.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16657" checksum="4B3A39D2BCE8B984" modified="2020-12-02" version="1">MSSDKKEVNEEKVDGVHHHVHHGSSPKKHDSTGSPSHKRTPFLVPSPVPTRRTRTTSQSRIASETPLRTGVCKTFCRNKGHGFILPDDGEKQIFVHISDIEGEYVLKEGDRVQFRTCPLPPKLTEEQAVEVTIIEYHGQHEKWWSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTS2</accession>
    <name>A0A6P8HTS2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamine-rich protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116295055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558628.1">
        <property type="nucleotide sequence ID" value="XM_031702768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116295055"/>
    <dbReference type="KEGG" id="aten:116295055"/>
    <dbReference type="InParanoid" id="A0A6P8HTS2"/>
    <dbReference type="OrthoDB" id="5985042at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057926">
        <property type="entry name" value="QRICH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF4">
        <property type="entry name" value="HYPOTHETICAL PROTEIN MGC115716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25561">
        <property type="entry name" value="QRICH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="QRICH1-like" evidence="6">
        <location>
            <begin position="94"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="221"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558628.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34302" checksum="E67D61F1D625D082" modified="2020-12-02" version="1">MASEDGSEDESIFITPSSSTCTIYVPEESDDHDFLKYITGTAAENHKDDSVEGKESSNLEENIRKKQDRFREPISASDCEKFEESWVSDASRRKWNWVLKVFKDWRDSRNQAIMNDVYSGEPLLNKELKELSEEDLNFFLVRFVAEVKKEDGSEYPGKTIYKMISNLQAYLHYNCKRDLYLIDKKGCKFRALNSALNFILKDRAGQGLGTVVKQANIITPXQVEILWEKGFLGSHKPEILRDTLVFVLGNCFALRAGQEHRNLRMHNSQLSIQTDESGEDYLQYVEDISKTNDKGASTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUA8</accession>
    <name>A0A6P8HUA8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dual specificity protein kinase shkE-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116293041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556295.1">
        <property type="nucleotide sequence ID" value="XM_031700435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HUA8"/>
    <dbReference type="FunCoup" id="A0A6P8HUA8">
        <property type="interactions" value="2546"/>
    </dbReference>
    <dbReference type="GeneID" id="116293041"/>
    <dbReference type="KEGG" id="aten:116293041"/>
    <dbReference type="InParanoid" id="A0A6P8HUA8"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097527">
        <property type="term" value="P:necroptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="253"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031556295.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57740" checksum="CCE95F8E9D386FC5" modified="2020-12-02" version="1">MLMLRIPWPRTFATHSWNGIERSRERRRNAHSLENCVRSLENELAARLEILKKDTDLVNSEQILDEFEKELMIQLKLNEPQKKLASEQEDMKIAKHPFERSEQRVRELEVTLAEERHDHEQTKENLKERSEKIHELDINLASTLKALEEKENELIRIRQISAAFEEKRVTEQQTTKEKEKPRERNEDKSNELQRKLACEQKAKEETEKRLQCCQEKSKEFETTLAMTQELVKHLKKQEPENECEWILNREEIQMTEEKLGSGTFGTVYKGMFRGTQVAVKQVSVKPKITEYNIRNFRREMKMASRCRHPCMLQFIGATSDDQSPLLLTELLDTSLKAVLLERALDLVEITTIAQDVAKGLNYLHLTRPHPIVHRDISSGNVLLWKHGQSWRGKISDYGNAVLMNYAKTGSGGAISYLAPEMNNKRFSPKSDVYSFGVLLLEMCLREEPSSLDDRDGLICLVENRELRTLIRSCLQEDPTQRPSMDEVLAALTTASSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUN2</accession>
    <name>A0A6P8HUN2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Prolactin-releasing peptide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116295347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
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        <scope>IDENTIFICATION</scope>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="279"/>
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        <location>
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            <end position="314"/>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
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            <dbReference type="RefSeq" id="XP_031558998.1"/>
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    <sequence length="360" mass="41579" checksum="FC6D691DE3ADB6AC" modified="2020-12-02" version="1">MSNSQNDDRVFSNISTQTEQDSKEHYQYSNYGISGQGSKIEHIILTCAYTIVILAGLIGNLLVIRAVKINQSMHTTTNFLIANISTADLITMLSCLPFVILKFYSHPDGMVGKMVCILITKNNLSCITLSVSIISLCILAVERYHALIKPMQHRLRMNKDNVLYVVFAIWLSSVVIALPLLIYTDYDQQLHRCQFTFSSQVYWIAVGTVTFLILVTICYCYFKVLREIYRKRILGTIPGITPQTRINEVRSRRKLVKLLLILTCAFVFFFTPRLVYLFFASMIPNDVRLSFRRLSFFLIVCNSCVNPIICAFQSENYRSAFERMLGFRSRRIEVEPSSFSMRRVERQLTFKSLRFQESQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWQ1</accession>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX52</accession>
    <name>A0A6P8HX52_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116296155</name>
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        <name type="scientific">Actinia tenebrosa</name>
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        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031559983.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41952" checksum="5C25FBFA68DF458E" modified="2020-12-02" version="1">MLSLFVSPNISNNSYVGVLSNDISQLNRGLKITLCSVVGVAGLLGNLLVILAVCRVPRMKTTTFYLIVNMSVSDILFTFISMPPFILGIAGYGLLVGGTLGSFLCKFVNFSVFSLMASSVLTMTAIAFDRFFAITKPMKDIINMVVLQRVVIAIWLISFVTSSPLIYSFQLGQDNIGCFCYEEWSPIFDEETGSRIYTLFDFIVIYMVPFLTIAVLYSLIARHLWFGKSSSSNGRQTQINLLRSRRKVVIMLITVIFFFIICWLPLQILTLLAYFSEIQDNREVLFMGEFLIRTNAAINPLLYLIFSSTFRQAVKETFVRSHTTRNPTIEITSPEKGNSGRRMSVPISYFSKNSIYHHNDSFLNLKRETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXH4</accession>
    <name>A0A6P8HXH4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heme-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116293997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031557365.1">
        <property type="nucleotide sequence ID" value="XM_031701505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXH4"/>
    <dbReference type="GeneID" id="116293997"/>
    <dbReference type="KEGG" id="aten:116293997"/>
    <dbReference type="InParanoid" id="A0A6P8HXH4"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000003">
        <property type="entry name" value="Heme-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF1">
        <property type="entry name" value="HEME-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031557365.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25819" checksum="637391DFED3A6FC2" modified="2020-12-02" version="1">MLSWFKGEEKPKIDTSEFHIPEFYRGADGPLIKVLETCDDYETRLYDKSQWVSSNAPPGEFMSAFWRLYSYIGGKNDQGKKMDMNMPVRIHVKLSEDDADGTKVEVFNVSFFLSSSLLPNLPKPLDEKVFLKQEDSRVTYVAHFSGMAKDKDWSDSRCRLMQALDRDGKSYVRAEYFSAGYDPPYKLWNRRNEMILLAADDQADDQTEEVEKTKEENTENEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXM5</accession>
    <name>A0A6P8HXM5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560106.1">
        <property type="nucleotide sequence ID" value="XM_031704246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HXM5"/>
    <dbReference type="FunCoup" id="A0A6P8HXM5">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="GeneID" id="116296250"/>
    <dbReference type="KEGG" id="aten:116296250"/>
    <dbReference type="InParanoid" id="A0A6P8HXM5"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF16">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560106.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54181" checksum="4588D4CE6FE1E10D" modified="2020-12-02" version="1">MQLKRKKLLTKISIGLFFFLAGVEYAVILPTMWMYSHERYGAEPWFYGVIFAAFSFSSLILSPFFGIWVDFTEKTKSTILFANLFEIGGNILYFVAWSKYWIFAGRLIAGVGAGAGSAIFAQIARTTTEEERTGVYSIAMGLRQFGLLVGPAFNIFLKETNFSIGPFKVDHYTSPGLFMAALWLIQEVIMIFMYYDLPTINEENDYNEEEEKKPLLSNESIQSNETKAIMNGTTPPVSGKVNAHDSLKDLTGSNSTSRKRRTSSLSENIALAKNLISEAVVVILASQFIMFFNETSFEALYTPLSNYYLGWRELEISISFCLIALEAILTFIIVKKLSTKLSDRWLMVIGIAFEASALILYLIMLTDIKPYEPKILPTIVIGTILIVFGLPFFSVANISLLSKITDKRTQGLYQGIQRSVTGVATILGPLWGGSLGHRMVIILSVMAGLEALLGVLMFLSFRRLRSPSKKTKDPLPSQYSEISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZY7</accession>
    <name>A0A6P8HZY7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand calcium-binding domain-containing protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560836.1">
        <property type="nucleotide sequence ID" value="XM_031704976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZY7"/>
    <dbReference type="FunCoup" id="A0A6P8HZY7">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="GeneID" id="116296869"/>
    <dbReference type="KEGG" id="aten:116296869"/>
    <dbReference type="InParanoid" id="A0A6P8HZY7"/>
    <dbReference type="OrthoDB" id="199400at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22968">
        <property type="entry name" value="DD_EFCAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46788">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46788:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560836.1"/>
        </source>
    </evidence>
    <sequence length="1251" mass="143192" checksum="1796C9F1DF0DDA2E" modified="2020-12-02" version="1">MEDVSPPRTASGSDRSRSLSAAMVFERSLIEREGTKSPVVRTFARNILKKWRDSKERAINKRLQEVKLEKKRREAESKEVARLITRTVPLDLLANEWMNDNNITADVRMYLVEKLLPTLILGVEKLLKEASKRNLEDSEGFCPDFNPINYLAQYLMRNNPKYSNFVESSPYAKGLHKITADLKKEIYSTEENKLAKLKAEARKKREVRETEERKRDIEERRRAYAIEEQFIEWTSDWKGMIPLAVVQNTLLSFQELAASFSEEVRKGADFCIPLEPTDTLGKLLDMDAYKQYMKPYAGNISTKAFDLFMNHLSASAKEYRAASLRQALQMMLQNLFLACDVNRVGELDRKRVLQLLGTFYDKAAGSDRKILRNPRQWPVIEVEETSSDDGSISEEDEEEPAPREEKQSKPPEEEKPKPAEEETVTEQGKEKDAEKEEAQQGPEDKKESEKPDEMSTAQEDQEKQPEKQPDKDSEKDPEKDAGKEPEKQNEQPGGEEIEKDEKKDEMKDETKEQKKDDADLSEEDKKLLNSIPEEFNSSEGTESETTVSGVYKPDTQSIVEGSAFDENSLNQSQFIHLTEKFLGDEPNRQLLEKLVRFIRSHYIEVDYDRLERINKARKDAYSAKKRKMVDQLFELWDVDMSGFIEVEKIQVVLSKWSSDNPNSFPEAYKILSEVTSKLDRLEFRECIKTIEFPDEESSFEELMQFLMACVERSFEERRRSETRKRWLGAIDVAAQTSGANLDPVYNAIFQILYKDAEEHGRGKTISAFVSMLENNEDMETISRGETVLRYVACTQEDIGCMLGKVIFRNMKAVSWAAVDTGKPIHVPKVGSHGGVQFWNPSRKPESTDGSFIVLPVKDSEKRVIGLLGIDTLNDSHKATFITHEISFFQGVAKALGQAIQFIDVRKKTLRVAESAVQWILRRSQNVLNVNVYLVEPGLRSTDGLVLRRMMLMSHNTLTQRFNNPPRLERKDNLFRDYLFKCVESSETITADAYGERHMAFPLRDAEGRAVAVVDISIGTLKALPPHENKEIQRMLRLLAMAHREVAREVAGIEKNIVLEVEKEHEEARIDVLFDRLMLLDLRENVGRLDARAFAEIKSYKDPPKVIHDILKAVLGIFYTDPELQERFEEWTTCKQYINQDLVKNLTLYDPTAKEHIVKVDAKTLARILQDVPQGAVAKHGSLPAQYLFNWAFVCLSLIEHTDKMTETRPGKVISPHATSSLMVDHGKGRRDSPTETINTVSKTGTGYGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3M6</accession>
    <name>A0A6P8I3M6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trefoil factor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116298752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031563159.1">
        <property type="nucleotide sequence ID" value="XM_031707299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3M6"/>
    <dbReference type="GeneID" id="116298752"/>
    <dbReference type="KEGG" id="aten:116298752"/>
    <dbReference type="InParanoid" id="A0A6P8I3M6"/>
    <dbReference type="OrthoDB" id="5946378at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017994">
        <property type="entry name" value="P_trefoil_chordata"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13826">
        <property type="entry name" value="INTESTINAL TREFOIL FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13826:SF14">
        <property type="entry name" value="TREFOIL FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00680">
        <property type="entry name" value="PTREFOIL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028221314" evidence="3">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="4">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031563159.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20193" checksum="E37DFC70779B2F3A" modified="2020-12-02" version="1">MAIIMTGLVVLFVSMLPIGVHTGVNMSLECSKHILQPRYRANCGFPGITKDQCENGHGGGRCCYDTSVKGVPWCFFGIKRLVCYKDVINPKNRVNCGFPGITKEQCEKRHGGRRCCYDDSVESVPWCFFETKKRISTKDRYLLQQFFFKLLKTHGTDTVVTRQVIRQPNNIAQEFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I3S9</accession>
    <name>A0A6P8I3S9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116295775</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031559564.1">
        <property type="nucleotide sequence ID" value="XM_031703704.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031559572.1">
        <property type="nucleotide sequence ID" value="XM_031703712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I3S9"/>
    <dbReference type="GeneID" id="116295775"/>
    <dbReference type="KEGG" id="aten:116295775"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF51">
        <property type="entry name" value="ANOCTAMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="194"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031559564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031559572.1"/>
        </source>
    </evidence>
    <sequence length="653" mass="74514" checksum="E1264BA601E9369C" modified="2020-12-02" version="1">MSGSTEEVVQLADSVKTLVVLEFSPKTPEETKKWLIGLIQAPVSTGGAGLQCKIEPDSLKKCDTLHLWGSTKRLLEGAEKFKVKKSHISGAMLDFCLNNCKEFKDFGSDGEGFLTTSESQRIVQCSLDAIKCHMDMSVPGYTEITLYKNRAIVPKIVSKGVLTAIYPLHEKNKLKALEHKWFLGFQAKQPLDDIREYYGDTIAMYFGFLGFYSLTLIPPVLLMVVFWFSNAHEQTKNTVFGVLNLLWATVFLEAWKRRCSELSFKWGTLKKNLGSEEIEEPRPNYWGPMRTSPITGQQEQYYPPMKRKIKTYCISYPIVLMCMKVATVVMLMYFRLQFYMEEKYAKSGGIVGSVMLLVPSIFYAVMIAVLNYAYHLLATYLTEWENHRLESSFKNHLIVKLVLFYFVNCFYSLFYIAFYLQDIELLRRHLAALLVTSQVIQQITESLIPYLMFRSRVTTVTKEGKKFVVKSADLSDQIERQGQQEVYIDTFADYLELFLQFGYTFLFSSVYPMAAFWALLNNVIEIRTDAFKMCRIFQRPFATPAASIGAWQSAFEAMSVIAVITNCALIGMAANSAHWLPDLTPVNAVLIFVAIEHFLLGAKFVLALVIPDVPQWVQDEMAKQDYQTQLSLKGNQGRPSRQTVGEPKETVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I421</accession>
    <name>A0A6P8I421_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC116298347</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC116298347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562623.1">
        <property type="nucleotide sequence ID" value="XM_031706763.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031562625.1">
        <property type="nucleotide sequence ID" value="XM_031706765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298347"/>
    <dbReference type="KEGG" id="aten:116298347"/>
    <dbReference type="OrthoDB" id="5945347at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF17">
        <property type="entry name" value="ENDONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653136" evidence="4">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="6">
        <location>
            <begin position="89"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031562623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031562625.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37372" checksum="B0E4904A2376445C" modified="2020-12-02" version="1">MMLLFVVVALLSINEMEGKSEEFKRKFGEHHAQPWKRDNDNAFANDINKCLFTKWTTASGSKDAVLSGPVQCKGQGGTAVQLCYGTAPPVAQFAVCYNTNTLIPDFTGHIVRKDIEGVGRDTDWRADVGTFAPKPQXTIADYDPYSQKGLYDNYDIQNQYFCAKGHLTPNADFTXDDQRLLTMITTNIAPQWQNFNSKNWAGLEEAVRTSARNDKRDVYVFTGVGGQARNLMGDIIKLNKRVLAPRWYWKAVCDPGAKQSIVFLGENAIGIADTTKAAGCNNIMQTKNAGIVYCYSLEGARKKYPDFKWPPFNENCKPSEKGTFMDNELRNAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I4W8</accession>
    <name>A0A6P8I4W8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-related protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116298272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562521.1">
        <property type="nucleotide sequence ID" value="XM_031706661.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I4W8">
        <property type="interactions" value="2267"/>
    </dbReference>
    <dbReference type="GeneID" id="116298272"/>
    <dbReference type="KEGG" id="aten:116298272"/>
    <dbReference type="InParanoid" id="A0A6P8I4W8"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031562521.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64223" checksum="836CDF8077937155" modified="2020-12-02" version="1">MVEGSQEQSNREKHIFTFKDFEPVPDAVFDYPGSIRDGKVPLVIDNGGYQCRAGWATDSKPKLVFRNLVAKSRGRKGEXDSGGIALGNDIGNLEMLRWSVKTQFDRDVVTHYECQPQVPQNNSSKNEEKDKLRRQKQGKRLQEINARRREEKIAREEARLKELNDIKDLEGKDEDAFKAALKGGGFQTSQSLQNAIKNLITSMQKRKEKLAAMQAAAELDEAGQASGSGVFIGVDSTSSEQPQSQDTKKRQRSPRGDTKGESSAEKRLKEEKKQEMQKAQDSGQQEEAFKSWLAGLKKRREEIYEARQQRRQRREELATRRSQASMERMRILSRLAYDPNVRDDGTTRQSHKKNKEDTFGQNDDDWMVYRAINKDAGDSDSEKEQEELNELENLLKKHDQEFARSEESKGAPLDWGEYHQLHLGVERIRVPEILFEPSMLGIEQAGITDTMDFILNHYSPRIQNSLVQNIFLTGGNTIFPNFQQRLEKELLAIRPFKSSFKIHKAANPRLDAWCGARKWASNSTNLTLGSITRKNYEEMGHDYLKEHFASNLYVPTPVNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6A6</accession>
    <name>A0A6P8I6A6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116298506</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116298506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031562866.1">
        <property type="nucleotide sequence ID" value="XM_031707006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6A6"/>
    <dbReference type="GeneID" id="116298506"/>
    <dbReference type="KEGG" id="aten:116298506"/>
    <dbReference type="InParanoid" id="A0A6P8I6A6"/>
    <dbReference type="OrthoDB" id="5954502at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031562866.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34594" checksum="A7B8CFE2D58AF167" modified="2020-12-02" version="1">MRKHIKLTQECLARPENVLDGTVVIRRAKGKRFGTFTRFDNLCNLFDNLFDNYTRTSKLRRCASAESFQQPQEVVLKSDIILLIGVISPSTKDFIRMESTYLSSPVLAPSSSRESAKDSNENTDSQSDTLSFGAVIQAKVMAGRARRRKSLFETEKCDNDIGASILSHADFPAASMSRSASKMSHSEGMGFDRELIYEILEHEVKQKLQSRTYDSTECESVCRQLANAVKERISALEIKNYKIVCTFYISKRAKPSMKMDSGCAWDELLATVDKDSFVDYVFQNDSISAVGSVYGVCCEKPRQKTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I6I7</accession>
    <name>A0A6P8I6I7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296721</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560647.1">
        <property type="nucleotide sequence ID" value="XM_031704787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I6I7"/>
    <dbReference type="GeneID" id="116296721"/>
    <dbReference type="KEGG" id="aten:116296721"/>
    <dbReference type="InParanoid" id="A0A6P8I6I7"/>
    <dbReference type="OrthoDB" id="5975880at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560647.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28404" checksum="F77C21ABED939AE9" modified="2020-12-02" version="1">MSGMTPLRFVRSAILSSFIGATGAVTYNTWKRDKNRAKQLLLYSATAGTSGLLVGYAIASFKRRNVYTHGLTVGGNFFVMTGAFLVFRDSILFQFGKGRKQLFTNESPDSNINILLARHPVSPMFASAVSGGLTGFILSSVFWRGPLVIASNSIQGIGLGVLGQFLYDKYRVWRLEKVLEYNYPQLTGNAPKPPQETELEEKLHWSDNIKNFLTRETYSSQVNNKIRHLQIQLELLEEEEEKLQSRLKAGENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7E3</accession>
    <name>A0A6P8I7E3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116299394</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031563908.1">
        <property type="nucleotide sequence ID" value="XM_031708048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7E3"/>
    <dbReference type="GeneID" id="116299394"/>
    <dbReference type="KEGG" id="aten:116299394"/>
    <dbReference type="InParanoid" id="A0A6P8I7E3"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027917338" description="procollagen-proline 4-dioxygenase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="456"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031563908.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="66467" checksum="05C9385BB746D6D8" modified="2020-12-02" version="1">MGVYGSFLAISLIFSTFFQPFRPEVFTSTSQLSEHTKVEQSLDKALQNYIKKEKQRLKKLKTFLRLKKKQSQKRLLDLEDLSGLTISPVDAFTTLNRFGKDWEDVGKQLRQREHREDFLNVLSEQNESLNLFSQMDFDGAMNALLRLSKVYDISPQNLLQGKIDKRSVKTVCTKGLINNQSRQLRQSIDQRIQNETCLIPTSFPPVQIDTQSITTRLTTMDSFRLGRQAYVTGHRLLAKTWLEHTISMMGNTQYALRDMAESTNRSEVLNYLAFIEYLFANYKKSLSYYQEMSRYDPSDEVKENVKIMEGLVAKNKVGERLSDDDDDQDEFMIEYANHCRKADQTVPLPSNDPRLNCYYDNRHPGSYLRPSKVETLNLNPRIEIFRDVLSDNEVDEIISLARPKLLRAGVNNLETGITELADYRISKNAWLRDQDSELVQKIDQRIGVLTGLNMNTAEHLQVNNYGLGGQYEPHVDHALNMSISPIRELGWGNRIATLMFYLSDVQAGGATVFIKLNVHSRPSKGDALFWYNLKKSGEGDLDTLHAGCPVLLGDKWVANKWIHEYGNEFLRPCGLTEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I7F8</accession>
    <name>A0A6P8I7F8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296701</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560620.1">
        <property type="nucleotide sequence ID" value="XM_031704760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I7F8"/>
    <dbReference type="GeneID" id="116296701"/>
    <dbReference type="KEGG" id="aten:116296701"/>
    <dbReference type="InParanoid" id="A0A6P8I7F8"/>
    <dbReference type="OrthoDB" id="10293508at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027877687" evidence="2">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031560620.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12019" checksum="50FE6EAC2BC07E6C" modified="2020-12-02" version="1">MARIIPLLLLITLSLCVTTQSRSQLGRWTNRRLVIKPKPKGDASSTTKVNLNDDELQNTALPSQSNGTPDSDKSIEQLENWKLMNSAYDNTIRHDPFYRRNEITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8D7</accession>
    <name>A0A6P8I8D7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116299741 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116299741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564318.1">
        <property type="nucleotide sequence ID" value="XM_031708458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I8D7"/>
    <dbReference type="GeneID" id="116299741"/>
    <dbReference type="KEGG" id="aten:116299741"/>
    <dbReference type="InParanoid" id="A0A6P8I8D7"/>
    <dbReference type="OrthoDB" id="289416at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038800">
        <property type="entry name" value="CCDC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33820">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33820:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031564318.1"/>
        </source>
    </evidence>
    <sequence length="743" mass="83518" checksum="4AF85D01B2E18F09" modified="2020-12-02" version="1">MERQQNDGLRKTPELSSEFQRLKAEHLEKMAGLKQESEMLKQLTEIERMKKELNEIKGNKVVVTNDEDKQKYETPFLMSTSGMEKSLLPSPYDPSAGFSVFLDFVLGMPSSSIKCRLAVGIYNVTELVSDVKVLPLVNVVNKHNSRIPSGGVAVFGIMYPFPKCAPIQTLSVIAELQANSTDDPQDPHKLFSKGWTKMDLFDTADRLISGRWKIPFRVPPIKTYLSYNELNRIPQVGMAELYIRLVNARDVKQEEILSPQPLQYYMYKYPTLDNPVHHYSRQRIVGKTPSTRESIDEPPLPPPTAPYRRDMRGAISLTSLKSEHNHSDSSSSITGFQVDQLYKAIDGEAKIKITAYSQQDGEILKAAGDTPVMCVTKSCKQDFLKDIYVFGLQEVRFRQVQWNSKSIVVVRVYLQPKDPGTDQIPAVNLLDESRLAAWTLIPLGYSNGRLSRQSAQGVGSSSSLNVGIHTVPIFFPPVPEITDMPVKIDKYPSEWSRYGRAALTMAIFSGFQRPLESPSPPPEYVEENEVPKNAWLKNARSFVTNKMFTPGSGFDLYIDGVRFLPDSVTVSKVAGRVMDKNYDKVGPDVEAQSKLYSDIYNPEFDHRLEFREPVFPATSTLMLKVYTVDRLSKKLCCLGYAVLPIFLKLGSTDPPSNNSDTEKFSLNEGAHQIRIFNGAPDFSQPLGPSLIQKLKPVPCASLLVRIVLAACHPNGRPKETSEFPESQWEREGLVVAKQRYEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8Z5</accession>
    <name>A0A6P8I8Z5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">A disintegrin and metalloproteinase with thrombospondin motifs adt-1-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">A disintegrin and metalloproteinase with thrombospondin motifs adt-1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC116297102</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031561120.1">
        <property type="nucleotide sequence ID" value="XM_031705260.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031561122.1">
        <property type="nucleotide sequence ID" value="XM_031705262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297102"/>
    <dbReference type="KEGG" id="aten:116297102"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000002">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653151" evidence="10">
        <location>
            <begin position="25"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="1152"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031561122.1"/>
        </source>
    </evidence>
    <sequence length="1468" mass="158058" checksum="B732E158C75DB08C" modified="2020-12-02" version="1">MTKFLICSLLFLAVLVDFPGIIYGQIHVETLGCFRAYSDPPVFPVIFLDYKYKADWTRFPNMNDLVQACAKAAKEKGYKYFAIQNFGECRWGASGLSLYSQHGRSTDCYGGVGGALSYYVYSFEKVLKSISYTEWSSWSICSVTCGNGIKVRRRQCLHGISSDCLEPVLQRMACTKDPCKEIYTSWGAWSICSKSCGSGRRYRIRSCLNWNNLDCWKWLDTEVCNKHNCSAQDSADDGQWSEWNPWSSCSVTCGGGFKKRTRTCTNPAPTKEGKPCVGVSSETSNCGTELCSVKIDGQWSNWGSWTSCPVTCGGGSQSRTRTCTNPAPANGGQDCSGNSSEKQECGASLCPVNGGWSTWKPWGPCSTTCGSGSQSRARTCTNPSPANGGENCQGESSETQACQVKLCPVDGQWSVWKAWTTCSATCGGGSQSRTRTCTNPAPANGGADCSGDPSESRVCGTNPCPVDGKWSDWKAWSSCSVTCGGGSQSRTRTCTNPEPANGGKNCVGESSETQACAEALCPVDGKWSDWKAWSACSATCGGGSQSRTRTCTNPAPANGGSDCVGVKLETQACGAQLCPVDGKWSDWKAWSSCSVTCGGGSQSRTRTCTNPTPANGGKECEGEDTQTQACQASHCPVDGKWTDWTEWKTCPVTCGGGSQSRTRACTNPAPSNGGKDCVGVDSETQACGTKLCPVDGKWSDWKPWSSCPVTCGGGSHSRSRSCTNPAPANGGKDCVGESSESQACGTNLCPVDGNWTVWTAWSSCPVTCGGGSQSRTRKCTNPEPANGGQDCVGGNSETQDCGTKLCPVDGKWSDWKPWSSCPVTCGGGSQSRERTCTNPTPANGGKDCIGENSETQACATNLCPVDGKWSEWKPWSTCPVTCGGGSQSRTRSCTNPAPANGGKDCVGDSSETQACGTKLCPVDGKWSDWKPWSSCPVTCGGGSQSRERTCTNPAPANGGKDCVGEISETQACATNLCPVDGKWSDWKPWSNCPVTCGGGSQSRERTCTNPAPANGGKDCVGDSSETQACGTTLCPVDGKWSDWKPWSPCPVTCGGGSQSRTRSCTNPAPANGGKDCVGENSETQECGTKQCPGCKIGELALDKCSQRCVCDSSGSFVNCTRIRQEFSSMSTADRERYINAVKLASTDPSYKTEYDNLITIHKVYFMKGIHGRMHFLTWHRWFILQYENLLRQIDCNITVPYWDWSVVSGNPWGTSPSDFWYSGNSGFGGNGVQPTGCVQTGVFREGAWTLVPSAGPSKCLKRFLNGHPPDSIAIAQLLKLDPKDFNSFELGLRVNFHDVVHCLIDGTMCSFDSAAAPEFFMHHGFVDKIWADWQKQSHEHKTVYFTELNEILPNAGVYSKFYVDNDNLTDKAVRVEYAPVNDNLLNSILIRLRSFSVQMLGRIPRVEFSKLDDRAVKVFSVTPEEVEEAKRLEALFNPQIRQSGLINPDALDQKLGFNHKLLDYISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I8Z9</accession>
    <name>A0A6P8I8Z9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein O-glucosyltransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116297484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58116"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62016"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="Rhea" id="RHEA-COMP:16011"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KDELC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561572.1">
        <property type="nucleotide sequence ID" value="XM_031705712.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8I8Z9">
        <property type="interactions" value="1544"/>
    </dbReference>
    <dbReference type="GeneID" id="116297484"/>
    <dbReference type="KEGG" id="aten:116297484"/>
    <dbReference type="InParanoid" id="A0A6P8I8Z9"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000419">
        <property type="entry name" value="KDEL (Lys-Asp-Glu-Leu) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF122">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Filamin" evidence="10">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="11">
        <location>
            <begin position="230"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031561572.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="59187" checksum="FE6D86CAA1D352AC" modified="2020-12-02" version="1">MSKYFTRMVFNSKILLLVTFCISFIVIQGAGISRKKTLIWGPGLRDGAVVPARYFFIQTVDTQGRNLTESPGENTFDVRITTSQGRARVWVQLLDRXDGSFIVRFRLFASYRDLRIEVLYKDKHVAQSPYQLTGGVYHEGCYCPESDTTKWEEAMQCPNNFSQMDRDLQKFSKINLKRLAKEGVERFGKHNALCHYSVINNKVYRKTHGEHVGFSMFMDAILLSLSRKVRLPDMEFFVNLGDWPLENKKNNPLPVLSWCGSEETXDIVMPTYDLTEAALEAMGRVSLDMLSVQANTGPKWKDKIPKAFWRGRDSRQERLDLVVMGRKKPELYDVALTNFFFFPYDENKYGPKMKHISFFDFFKWKYQINIDGTVAAYRMPYLIAGDSVVLKQDSNYYEHFYXDLKPWEHYIPFKRDLKDLEEKLHWAIDNDDKAQKIAQQAQQYARDHLQAIDVFCYHWVLFREYAKRQTTKPVIHKGMEYIKQPDDNDNRCDCLRKTKNRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I982</accession>
    <name>A0A6P8I982_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tissue inhibitor of metalloproteinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116297558</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031561667.1">
        <property type="nucleotide sequence ID" value="XM_031705807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8I982"/>
    <dbReference type="FunCoup" id="A0A6P8I982">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="GeneID" id="116297558"/>
    <dbReference type="KEGG" id="aten:116297558"/>
    <dbReference type="InParanoid" id="A0A6P8I982"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
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    <sequence length="228" mass="25806" checksum="031CA553997D6433" modified="2020-12-02" version="1">MALWETVVVLLCVITMTSACSCMPAHPQEHFCQAQFVIRGKVISGPVQVLPDNYFVSSNVLGRFLAERVYTFRITKTYKGAAAIKKTDSLKVYGSRGRSVITKIYTPSKLNSCRVDLDVGKVYVIAGYIGRKKLSISGCSLRMEWEKITKKQRSGFARKYGRSCECVHQKCYKDCGKESQEMACNFEISRNPANECRDRYGYCQLSSDGRSCSWTTNALYRKCMKKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="1305" mass="143638" checksum="8A657DC7CD8920C0" modified="2020-12-02" version="1">MTAGTDPDPAESSNAVKMPSIMQIRHIPYLDHNYGQPPPMTPPDSSSPTPDDVDTGNEDDEGNAITRCICGFNHDDGYMICCDKCSVWQHIECMGISSENLPENYLCEQCDPRVLDRDRAKAIQSRKREEMSDDDDDDDESAEDADGTLYTAVSNTPTRITLTAKVSHQKRKNPGPRVKGEKDKEKKQKRTKRQKQRLSADFLPVDEETNGPWESNCSKSEYYTEVKECIYSQEILEYMAKLPQNNQEALIPEGTEQFCKIVEVQRNTKGLVTTEDLHKNQFLVKYNGKMMLRHEFDEENPVFRRYNPYVLFYDHQDHLKLCVDARVMGNDARFVRRSCSPNTEVRCIVQNGKLNLVLFSLYPLPKGAEITIPFEFSLAEYNCSLSCACAQDTCTVAKYKLKHQVPSQELNSIMEHNGHKLCDDSSNSSHNPLTTSPLRATLATQNSFQGDSDSDLDNNHERSEAENRRKKLSREERKLEAYVKQIEKMEKKEKKRQQPQKEHRPVLRVSSDEGKAQIRGIRGQRQLSHKRRSNGSSSVLKKKRACASSCSSEPLSPDEVSSSASTPTTPKTVTTIAEEPLVETPSTSPSRNFRFPKTKGDENSQDGYFKTEAVSSSILSSPISPCSPRESETETKQTLSTASSNSDIAMEIEMEESEAGRLEDSCDQVQVSLHSSTTGDLGSALSVRLAEITNVAGTESNTPSPCPSTSASPTSSESVMNGCPSVVISDGRSPGPAPGSPLAALLHGVHVSRSNPYYYSLKKRWLCKFLYSHNGVGVARPANGLRTSLGILQPPKVATLNNKTFHSKLNNTVPLPLKKRHLKYLKTSLGTKDEVMNNRTLNNDNISSTHNGPLSDTSDIKPSFNQYVSCGEEHKPASSVHCTVMSNTSKEVIKSSQSRTLENRPSNTRTLDIIQNEVPSNSVDTAQVSYQSTTEHSVQAIVGRGTLDTVPDVKPVMISTTAVRRPSDPRLLSPSASISQQFPQQPTSTVIQTVPITTSVTQSSDVSSGTPGKKKVSLLEYRNRSLQRLSGDGSKPSQPTSSSSTPLGSSSASSVATSVVRSNSEPQPSLSSSALIKKPKNWEANGPRIEPISPDENERIKLSTSSMTGLTTCNTPLFEALAKKEVGMNMYNKKLSALISEQLLSDPKYSPTSSKSPSTASNSPSIPPPPPPPLDTAGKGDAMEIEEEDGVSDQKIFLTTPLVSTSRTPIQPSTQPTSLISEYGHPHQISEYHPSVHDQHLHTRAQNLMVPMMQPSSSQLPSHSQSRITSTPYLVAATASPAMPSQVRFPSYQNPSLQSTTYYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICB9</accession>
    <name>A0A6P8ICB9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC116298888 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116298888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031563327.1">
        <property type="nucleotide sequence ID" value="XM_031707467.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116298888"/>
    <dbReference type="KEGG" id="aten:116298888"/>
    <dbReference type="InParanoid" id="A0A6P8ICB9"/>
    <dbReference type="OrthoDB" id="5985333at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028343036" evidence="9">
        <location>
            <begin position="35"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031563327.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58040" checksum="275B224A4E96132E" modified="2020-12-02" version="1">MLMIRTKAKAWKSNFLSSLYSQILLLLCSGCVNGNLNHSYAMDEACLTGKMIHVRYVDNAPYIFKRNDEMKGILLEIFEKGVQFCCKDGVQISYNLSTSNNILELRTKHVGFLPLSRASQIISSIHGLPFVSLIESPGFAVVSVKSVPGEDLLMAILDSWPILVFIITTISLSGICIWVLDFHVNPKHFPAFFPLGVCEGFWWAAVTMTTVGYGDKVPKSVGGRLFAVVWISAGLVILAMFMGIVTASLTSSGIGQINHLYGLEVSAINGSAEYQFAILQSAYVQAQDSYTSVYSSIASGKPKLALVDLYATTQHQNFFSRHNLRVSMXIEQELSYGLVLPQGTQNLHQCLREYKEAYQFQSYSYIQKYLTKHKIPDISDGTEYFHGIFGYSVYAMTGVFILILAVGFWWQYYWLKRRGEWKEENEDIDMTELELSTMGPYHCSKTQHIPQVCNSSTVNHWSSYMMAQQSTQIQGLIDEYMSYEGNWTRRFESLQTKHRREQVEIFNLDRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ICF3</accession>
    <name>A0A6P8ICF3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116298939 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116298939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031563382.1">
        <property type="nucleotide sequence ID" value="XM_031707522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ICF3"/>
    <dbReference type="GeneID" id="116298939"/>
    <dbReference type="KEGG" id="aten:116298939"/>
    <dbReference type="InParanoid" id="A0A6P8ICF3"/>
    <dbReference type="OrthoDB" id="10317192at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031563382.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28531" checksum="1B7EFDDD721A91EE" modified="2020-12-02" version="1">MTIYKKGADSKAKIILNRSTSGLVRTLRSDIFNSKLNMNLNVKLSIWLYAITSFTLLVDSLSIKNDYYAYINEDEALERAMPLNEPEFGVEMEEMDSKEDSTCTNGTFTICKPITASKILGVLKQLGVRQNPAIRIAKVSKRFLRELKMNNGTLKATQRKRRSSNNYSELCEEKEVVMNFQLIHPKVSLLYVVRGVTCVNKFCFSQYCAPDNPIGKCILTKSQVFLHLFDDYGTLCGKTLEVGVACKCRPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IDA6</accession>
    <name>A0A6P8IDA6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Uncharacterized protein LOC116299563</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC116299563</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="28">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031564097.1">
        <property type="nucleotide sequence ID" value="XM_031708237.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116299563"/>
    <dbReference type="KEGG" id="aten:116299563"/>
    <dbReference type="InParanoid" id="A0A6P8IDA6"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08685">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0768">Sushi</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027732821" evidence="19">
        <location>
            <begin position="23"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1478"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1515"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1540"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1585"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1626"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1663"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1699"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="domain" description="GON" evidence="26">
        <location>
            <begin position="164"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="20">
        <location>
            <begin position="375"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="661"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="755"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="852"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="1013"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="25">
        <location>
            <begin position="1052"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="1122"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="22">
        <location>
            <begin position="1306"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="23">
        <location>
            <begin position="1480"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1765"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1846"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1848"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1083"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
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            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_031564097.1"/>
        </source>
    </evidence>
    <sequence length="1999" mass="222222" checksum="B1AB9C425B0B8238" modified="2020-12-02" version="1">MARGIWLRFVILLLSWLRCSCSQSCAGRCSCSTRGIPGQDTYEKIVNCSARALPSVPNTIPSDTTELNIKNNVISWLDTNVFRTLPKLQKVDLSNNNLQTLPHDVFNYNPSLREVHLNGNPLTCDCNLYGTYNISQHLAKFSGICSNPPSLANRELQSLKVYEFCGGCAGIKMTGKGSRDKEYFIQLKVKCEAFASVYCHGMNTNSPKEYISLRSGPVSNYALIYDYKQPESAKYECDQQTGGVLYSEAGITNFTKVRLILGPNSATVVSDDFQFATKVGKTVPLGVAGDCYSASPNNCRKGRFKIDLTGTGFHLKDGVHWEHYGTPSNINNTLEVDTDRSIVYGECGGYCGGCRPRGDIHLELDACPEEGVKPCSTSLGMDDRSIEDSQITALSNIANYLPSYGRLNNIKSASMGGSWCAGTSDVNQYLQIDMKKKMTFSGIATQGAGDAQNWLTKFKIMKSDDGNSFTDHTEFGIVKDFYANKDNYNVVTNWFSQRFRARYIRIMPLEWSNAICLRAELYGCDNDMVSVVVRKKSGDKRCWSPHGSEECNFADGTSMVLKSDCQGKGVMITFRKNNAIIHTCSGKCVTIDNNNLLTLRDGPCDTFRKQEKGVNEFIIIHEKSKLCIGLGNVKTGLLLLAACDLQPTLFEFSQDGISPLPPIITYADDNYLEVNKSGWVHCQVTADPRAQIFWSKTRPWPDGQSLSKLEFLQSLSGSLYVRKARMSYSGRYYCSAANTADFKFGSLNIKVGSPPNITLGPVDTKVVLNATVMLNCKVTNSNLPTKIFWYKRGPNRTAVSVDKLDLRFLVLTNMSLRIRLVQKNDEAHYLCVAKNPLGSNNSTAFLKVLIPPKFYVFPKDIEVPSSSSPIIHCKGIGDPAPVIKWFHKGSLNLPPNFKVYPNGSLFMSNIEKIDQGLYMCSASNEAGTVQVEAAVKVYVACRIDSIPYATYVPHXMFFHVDESTVVTCKTGYQMRQGPKFNITCVASGKFNKAIPKCKDIDECRVDPSTELNNHNVTKYHKCNKNALCVNTPGSYRCECSEGYKXNGTSCEPLCSRPKIPINARNWLPEQKYYDIGSSITLICKPGFKTESKSSVTCNSSHASFGHLPSCKDMDECVVGVQDINSGELHSACHHNAECSNSIGSYRCMCKSGFEGDGFNTCTVVKERLVKSSSGKEWKFSPKMDAVKDKLKEYKAKNTTAAAVLKVLEERTGVKQETLTSGDLIIIFETVKELLNDAKTPGTQTSKTEELKTVTKVCSNILAEDNKEHWEKIQKDSKGVTEVMKLMEDYTSALADDVVTLQASGNSSFLLDTDNIGLKLGVYQAKALYDGHKYPEGEQNPQVIIPGEVFHDYKSGLQSIKIVGITYKGLGNILPNRAEGVEKFDVDSSSVISTSLYPSPAMHDGKLPAPVKIALVKQKTTKQSAVPKCVFWDFKTDPDRGGSWSSEGCRVVVSSDNGTLCQCDHMTSFASLAVYDKELVFSLVVYIGCGILLLAVFILAIRHLCLYCKRKSERSVIHLHLYFAIAAAVGLFIGALKLTKIKAVCVLVAALLHYFFMAMFCWIIVKCLQIYMTLVTGKNKNRSRIKWFYIIGWLLPAVVVGASLGIFQLKGYGNSDWCWLDYKDRLLMWAFAGPAAAFFFVTLIFAILICVLKGRVLDSTDKSKISVALLLAVLLEIVIGGTWVAAAIYVKHHQARLWEYLFAGLCVLQGITLLVFGLLDKEIKNFSFLYQIKKIQQREHKEKRNYYSTTDTIQYYGAANAPDGKTYTVTRPSAKESIGDLRGSSKRLSRIGSNQEVNEPPDYPPLIVESPPELDDSYRRKIESQPIPYTPSYPNSEVIQLQTFPVRKASSETHSRFSSERQPDGAEAAELSPSNEHKDRYYSLPRSIGTSPAHSKLEQIPEKAPLLTDYQHSTTNATKSYQTPKVCTESCVTDSEKVPLTGDSSRRRSERAKARLEERYKMDKDSINRRKRKLRYSSGFLIGATIEEDRKPGEKDHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE46</accession>
    <name>A0A6P8IE46_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Axin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116299498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564020.1">
        <property type="nucleotide sequence ID" value="XM_031708160.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IE46">
        <property type="interactions" value="2224"/>
    </dbReference>
    <dbReference type="GeneID" id="116299498"/>
    <dbReference type="KEGG" id="aten:116299498"/>
    <dbReference type="InParanoid" id="A0A6P8IE46"/>
    <dbReference type="OrthoDB" id="10007451at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Axin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102:SF2">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="122"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DIX" evidence="7">
        <location>
            <begin position="748"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="488"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031564020.1"/>
        </source>
    </evidence>
    <sequence length="833" mass="93719" checksum="A12BEBFCFCC83C5E" modified="2020-12-02" version="1">MEPREKDSSVPNTQGSFRTLDHSSTREIESANARLYNMPRPPPTGEDSSENDRSKEGLGQFKADSYEPPSPRLTPRRSTAKELPISHGASLATDEEKLAPLGFEPEGQAVSSPTFHERLGTCFTDKLSDCDESYVFYQYLRRINRDILLDFCRTCDDFRGMVPTSPQTRSTAKAIFQKYIFSRDTCDLLGIKESSRTKIAEHISDQPTDPLLFEQACSEVMVNLKTTYYESFLSSSFYKEFTETHCESPKIINEMVAPYSGRFQGGYLPTLPEEKVLGFGEEIEEFEYDQQCKNTKGLSGLTYTSTDPTSDEKNARKLLHNPVKDTSSPYYYPTAPLASITESVESQSMSSDALTDDTLSMTTDTSDGHSRHSGGRRHPXRSRNPSNPMSRFPFVPRTHRMPKEARNPLSPEEFVRILNQKLEKVVIERQLQEREAINLSHSIDVESASSGHSKKSILQEAIENKERRDRIPLSTMAMMSPLLVQDDTTSISTSNHSSSKSTSANATAGSGAVNSSSSDSTHKRSKSKHGSKSSRQESDKSCEQAPHLNRECNKPPKKVTIPSDNNIPFLTVNHHRIMKWMETGEEELQREKTTKVRHQSKSSRQSSSSSRTGENYTSQLQPNQPIAQDPNMPLLPQPEATTVLGEVRRRLMESKEQERRSKHSQKHRSRASVDNTSDSMSSFQDKXSSTDCSSCAQSLLSYDLKPHQSCEASSTFSSIPSSASNINNDTKSRSDSGIGTGLRKKEKHNSTTIIYWLWGEPIAYRTSLPGKNVTLGQFKTLIMRKGEFRYFFKTKTDEEDRDCEVVYEEVRDDESKLPLYEGKIVGKVEKVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IE73</accession>
    <name>A0A6P8IE73_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel subfamily A member 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116300263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031564952.1">
        <property type="nucleotide sequence ID" value="XM_031709092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IE73"/>
    <dbReference type="GeneID" id="116300263"/>
    <dbReference type="KEGG" id="aten:116300263"/>
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    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000264">
        <property type="entry name" value="Potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000157">
        <property type="entry name" value="Potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000074">
        <property type="entry name" value="SHaW family of potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031564952.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="54056" checksum="1D61CF66044DCBBA" modified="2020-12-02" version="1">MLTTASVPSTVQHSNEPPRGTGIYRYKQIIEQMDGIGQTAAASSMSDPIVINVSGKRFETYEETLARFPDTLLGCPSRRAKFYNSKKGEYFFDRHRSAFDAVLYYYQAGGTLIRPEHVPPHVFINEAIFYDLPEEALNTVQQEAGIVDEPGEKILPKNFYCRVIWQTLEFPEYSCFAKFLAIFSVVIIVLSLIIFCVETLPEFSPEPPKKPENATADWLPPPGPYDETWFMLNTFVIIWFTGEYLLRLLVSPDKIQFLVSSLNIIDLLSVLPYYVQLALDKNGNSSISVLRVVRVVRVFRVFKLSRHSRGLQILGNTLKASLNELLMLMFFLGIGVMIFGSCVYYAEGGLDSDFQSIPHSFWWAVVTMTTVGYGDISPKSLWGKLVGALCAISGVLTIALPVPVIVSNFENFYNKEVNRRKEEQLRKDEEERQRQQEKRNKEKKMEEMGVSKSSRGILVCGVNGCDEPPNPTIAQTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IES0</accession>
    <name>A0A6P8IES0_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116300019</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031564640.1">
        <property type="nucleotide sequence ID" value="XM_031708780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300019"/>
    <dbReference type="KEGG" id="aten:116300019"/>
    <dbReference type="InParanoid" id="A0A6P8IES0"/>
    <dbReference type="OrthoDB" id="5965869at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031564640.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31728" checksum="D318134362811C51" modified="2020-12-02" version="1">MDASPTQTTLISSQDSTSSTSEFVDTCTPLAPKQKGRFNVGLYAKRRKLIMEKLVDEKIATDVKLKSFQNKPNYRKRKCDDLXEQLPSSKXKARLPNTQSNLNKENSDFLDLSKAQSHRRRTATIKVLREVHCTPRSTDNKPIMNGMWSTLVNNNSVKFMESLIGTSKFCTSKVIPNIVKKNVLSYENSEDNFIRSTALLYKGGILTKVKYKEMRNERINFMSDVPVPRPVAYDRLVSYIKGINMGDVLDLEVSLRLPYYMFTVLRMQAFAYGTVFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF30</accession>
    <name>A0A6P8IF30_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein rolling stone-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116300452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565190.1">
        <property type="nucleotide sequence ID" value="XM_031709330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300452"/>
    <dbReference type="KEGG" id="aten:116300452"/>
    <dbReference type="InParanoid" id="A0A6P8IF30"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049352">
        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF49">
        <property type="entry name" value="HEADBUTT, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031565190.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35800" checksum="157A51491074E2E2" modified="2020-12-02" version="1">MPAGMDLKELLLSELQLKNFRLLYHDASDFTESPFFAVLFVVLYRLFFAIYCFGWLIASGLHPSNGDEKWFIYLXNWSYFFLTVYFVCSMILTAIYYRGEWMVGEYDVQNHDVLKPKSRSRPGELNQQPQEDLEENVVNPLDLRHQEPVHWYHQTIWAVFNIAATNAVVVTVXYWTAXYPXYPDSYTPNGLDISTHLLNTIFILIDICLSCMPIRLYHVIYPMLFFFVYVIFTVVYWASDGTNVGGHMYIYKTLDYTGNPGSAAALILGYMFIGLVLTQLILFGLSKLRSWISEKVYSGRRRGYEVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IF84</accession>
    <name>A0A6P8IF84_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116300622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031565385.1">
        <property type="nucleotide sequence ID" value="XM_031709525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116300622"/>
    <dbReference type="KEGG" id="aten:116300622"/>
    <dbReference type="InParanoid" id="A0A6P8IF84"/>
    <dbReference type="OrthoDB" id="5958014at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="26"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031565385.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59759" checksum="EDF8657D41A770FD" modified="2020-12-02" version="1">MKMAVDEPKEHILDKIGSFGLYQLRLFGIMNYAIFFFVMVFLVMTFSTAEPPWKCKANSTSCTLNGTFKAGDKDYEHRCSIPRKDWEFAVEGNFDSIVTEWDLVCERGEQASLVNSLTFLFGIVGVLATSILGDKYGRKNMVFFTYFFLCTCGLLSAFAQTYWVFALFRCLVGLGMGIIPSSFTLVMEXVGARHRSMVGTAYWTSWEISLCVLALLGYLLQSWRLLTIIASAPGMLFILFWWYTPESLRWFLVKGRIDEAKKTLKTAARVNKKVLLDDDMTLLAVNEDRGNLGEKERLGDIRDLFASRSKAHIILFSWYCWFVNGLVFYGITLSAPTVGGNMYLNFFLQAVCEALAIIVGIPALNRFGRKKTVXFGLWMAGVFMFSAALLSYYDDGSEGFLAGKILSAIVLGKLFITLSFNSVCVHSSEFFPTVIRNTAMGFLEAASNIGSACSSYVVYSISYDIHLIPPQQRVHPLMPFGIMAINTLICGIMFMTLPDTNKKAMPDTIKQADLMIQNTSVRVDEYPCNQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IFM7</accession>
    <name>A0A6P8IFM7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DDB1- and CUL4-associated factor 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116300757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat DCAF12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031565544.1">
        <property type="nucleotide sequence ID" value="XM_031709684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IFM7"/>
    <dbReference type="FunCoup" id="A0A6P8IFM7">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="GeneID" id="116300757"/>
    <dbReference type="KEGG" id="aten:116300757"/>
    <dbReference type="InParanoid" id="A0A6P8IFM7"/>
    <dbReference type="OrthoDB" id="9610195at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF16">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="11">
        <location>
            <begin position="39"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031565544.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="43976" checksum="E85A5DD74796525B" modified="2020-12-02" version="1">MKSVFEYLSTRRQSTDAKLSSQTVTDLISHRVPLTWKPSNVPLGTIDKVFASKWLDDRRVICGTKCNQLVVIDVVTKERVFIPMLEGSPHATPQMVSAGVHDIALNQSQTMLASNGENPNHLAVYKLPTFDPVCVGEGHSDWVFATEWIDDRLLATGSRDGTISIWNTYGGEPAYTSNKLVGTTNGKEKAKIMPAYVSPKTTLTGTVEADRIRDLAYNSNTGNLAALSPHSLVHVWDIASGKQLSSFPLPFYYENVCLALEKDRSLYAIGSQSHVSLVDLRSYKMVKNIRTYDPGAGVRSVSFQDVLLTIGTGHGSVVFYDLVANGFLVTDTKDDLTLKSGKGWLRLDNTLYEYFTETEVDCFSNAIYTHCYDPTGTKLFTAGGPLALVLYGNYAAVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IGN5</accession>
    <name>A0A6P8IGN5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin and armadillo repeat-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116300995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031565845.1">
        <property type="nucleotide sequence ID" value="XM_031709985.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8IGN5">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="GeneID" id="116300995"/>
    <dbReference type="KEGG" id="aten:116300995"/>
    <dbReference type="InParanoid" id="A0A6P8IGN5"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043379">
        <property type="entry name" value="ANKAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46464:SF1">
        <property type="entry name" value="ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="785"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="826"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1334"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1401"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1401"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031565845.1"/>
        </source>
    </evidence>
    <sequence length="1457" mass="162064" checksum="36CBF1FC9AC3D96A" modified="2020-12-02" version="1">MSSRAGGRNASTSSSSDVMNSLTASRVAATYFDKIERYELQESLAYYSSDWLLSTEDTKISVDPPVGLISGIQISSNLDNCLVLIPHEEGIEPLELREMHQIVRELVMGIYVLNQTPSICLEANYDCSTSCQIPPAYYDTRVGQIMVEVDYMMKSLWHGAYFPKDKRTKFVERWRQAVNLNTMTGVPETRRSLELVWTEAGIQDLSKDPEFTKAYESLPVDNKDDLTVAEERKNFMKNVDDLALKMTFKQKTINQHQNMFLLDSDYHISSVVRSDKLDQQSYEKLQRRLTIHQEFIRKYLPLKAEIHCLLVLLKFISFMVPFLVAIKKRCKVPDVTKLLPSFTFEECKTEREFPPLMLRKEFTCKNFDSSEKYFHLHGGIYFDRETGSTQKINEQIIAQKEHLEYTASDDYNKIITSDTVMLESYPIKPIKIDNKSYYVLNISLETYYPSSPKHPLWIHAHYDEISKLKPKRLPIPELQIHEQYKKRYGYQRTVKLKQIPAGLQASAIRGLVAIFYTMCRKLPPSRLNTQDSNGLSLIHHAAMFNRPQMITMLVVMGFDVNVRRYNNISSQGVSPLHLAARCGALDSLTCLIAYRADVSIFDDQGWAPIHYAAYYNHVDCLMHLVHKEPKLLEITSTDDTLSTPILLAASSGALDVIKCLIDAKACYTVTNCQGNGVVHLAALHFHTNVLEYFIEWSNQELPVWDILVGMLKSEDLSRKESAIKCMEVLSVAKETNWKSILYAGGIPALVALLKIENEDLQSLACSVLCNIGSHIEVRVAVSATDATGVIVQLLSSPNVMIHSRASVVIADLACVDNNQDKIAEQGGVEALVSLLESKVEHVLVNTVNAIRVLVEEHKNNQTTVANSDAVEILIDLLGTYSKRLQANTAACLSALVKHHHENQNLVIAKGAVKPLVKQLRNTSSLCQVKAASALEALAENNPDAQGIIEKAEAAKPLIRLLKVWSIEVKEQAAGALWALAGAVHLQQQEIAGLIGVNILVDMLMLKSEVLQYISGMAMIALGTENIENQNKIVAGGGVQPLVRLLRSGKTSEKVLLMVIRVLGVLCVGPAHQSNKSTQVEIANAEALITLVHLLRTSRVSLIQVETAICIGKIALNNTTTQKILSEQTKFRVVDIMHLLKDPDQEVRLKSGMALATFAYNNTTQQYAIKKAGGLLLSSFEEFLTSPKQLHQAHAAFQIIVLARVIGDCDQVTLTARGVELLVSLLRSEEQATQILSASLTASLGHTRAGIPDALITAGAVESLLKSLFSDNEGVRISAAVALGYLSFNRTAERLMLVACRNTPGLYDSLLANLGGGKLSMIFIDDWNETKGVGLPSESLEINGGPPVPKKDAPREVRRRPHTTQPSTRRARRQEMSSKRIASAPVMDSYRNQVKGKVIQAMKTTSSSRKTMSPRLTEGEYDDPVEAAAGLWKTKLLAHRPNLDNKLKKMTISESVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IHZ8</accession>
    <name>A0A6P8IHZ8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116301497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566427.1">
        <property type="nucleotide sequence ID" value="XM_031710567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IHZ8"/>
    <dbReference type="FunCoup" id="A0A6P8IHZ8">
        <property type="interactions" value="2175"/>
    </dbReference>
    <dbReference type="GeneID" id="116301497"/>
    <dbReference type="KEGG" id="aten:116301497"/>
    <dbReference type="InParanoid" id="A0A6P8IHZ8"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031566427.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20187" checksum="54C1F972D8179795" modified="2020-12-02" version="1">MGGFFSSLFSSLFGQKELRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSVDRERIGISKQELVSMLEEDELKKAILVVFANKQDMEGALSSTEVSNALGLSALKNRTWAIFKTSAVKGEGLDEAMEWLVDALKARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIB6</accession>
    <name>A0A6P8IIB6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Double-strand-break repair protein rad21 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC116301533</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031566468.1">
        <property type="nucleotide sequence ID" value="XM_031710608.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031566469.1">
        <property type="nucleotide sequence ID" value="XM_031710609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIB6"/>
    <dbReference type="GeneID" id="116301533"/>
    <dbReference type="KEGG" id="aten:116301533"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="528"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031566468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031566469.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="65509" checksum="58A226200CFCAAAF" modified="2020-12-02" version="1">MFYHTFILAKKGPMARVWLAAHWEKKLSKAVVFETDIKSSVESIVSPKIKMALRTSGHLLLGVVRIYSRKAKYLLADCSEAFVKIKMAFRPGVVDLPEEGRELAFSAITLPEVFTDLDMTLPELNDIELQAQFTLNQSRIEEITMKEDVVVNNLLGDEGFGDIPFDSDGEKEIMRAGTGMEESLYQSKDLSKITLNETDVGKGIADSTFERSKIDLALDEPIKDDGFGGDGVDFLADGFGDGLGDALVPGIDDLPPVAADELPLEPIDTNIEGEELKKDDTSPLDNHNETGANTTNELTILQNEAEAFVLEPVEVVQKGKRSRRKRKLIVDEDKILSTDAIKAQLSDTTDVVKHATLAPPTKRRMKLKTKSTVEQLFALPALELLASPLVEVFVINLTHKAANELKTVNHEAEEKMDTDEMDQEVPQESTSSGDKTQKRTSVSFEEPLPSMDEPLQDMVQAEMPFPEQLEPEQEEKESEKEDVAELPSSQMDEEQKMNTETEEQFENRRWTKRTSQLIHTLKREFNKKDTVNFNNLVQKNTRKQAAYKFYSCLLLSKDNTLNMKQKDLFGDIMLNKGAHFAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IIU9</accession>
    <name>A0A6P8IIU9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Metabotropic glutamate receptor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116301808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031566786.1">
        <property type="nucleotide sequence ID" value="XM_031710926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IIU9"/>
    <dbReference type="GeneID" id="116301808"/>
    <dbReference type="KEGG" id="aten:116301808"/>
    <dbReference type="InParanoid" id="A0A6P8IIU9"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01094">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027671194" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="572"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031566786.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118481" checksum="53B1D2A4A8E0A9DA" modified="2020-12-02" version="1">MITLHLIILNAIFVYVSPVNSLINTTIIDEEVSVYQPADVILGGLFPVHSSRLGGKCGDLDMESIALIEAMIYTTDRVNRESLIPWNLTLGYDIRDTCNLVAVSLKRTLDFLSEKKYSITDGDLERCGSNGRQSCDGKLVSVIGAGRNEISVAVNKVLSVFEIPQIGYASTSGILSDKSRFPSFSRTVVPGSHRPKVMSKVVAHFGWTYVALVTSNDPHWRSLSIKFKNLAHSKGICIGIEETLPNNSSAKEMQSIIARIKSKEKLKIILLFTSPLDTNNIIIRADTAKMTGRVWVASEVLAGSSSVMSEHASVTQGMLVIANKLDSVAEFAKYFENLNPAQNTRNPWLRNLWEKVFDCSFMETNKKMCKGTEKMNGIRHMLSFSHVNHVIDAIMAVCHVIKRICKEFIHVNDTRGKEKCLNELTKTKVLSEMFLGPFVFQSLSNRKVYLDSNGDAVSSYRIENLQISFQGAKFQTIGMYSGNTLDIEKNQIQWPNKSITQPFGKCSFPCNAGSYRIHVGSRCCWKCAKCPVGSISKNGLKCTACQSGFTSNENNTSCRKIMHDFFGWGTKEADAIIAVSIISFVLSLTVYVTLIIYKTTPIVSGLGSDTNFRLLWSISFGVLVPFAYIGLPSDNMCKIQSVLFGTSLTFTMSLVLAKAKQLTSKRKKLASRWLVRINSQSQFIFSLFLTIVELFICILWIINKPPSAQIREESAGRSIVVCDNTTSAWYALSAFHILVISIACTYLSYSVRKRLVNYSEAKYILYGMIAFYTIWVILTAVLYGTPVGLHDVAINCLAIIASQLIFLVFIFFPKLYIVFFKSKLNKDAVFYALISADHEIECACKDSKEKLEAEQPSTRPHSLSFREVSSREFPSDLSLETKTFRPSLLKKLSAWPCCACLQRDSTSAADFSDSRENVNNRLALNSYPLPIISIEEGSRSQTSDPGYNVRDDVITNYPTDRCNCDFHPPEDHEYQAENIVSLTAAEDRGAIRGAKIWNKQNGSSEDKLGKRRSRCDNGAPCEKPEEKRISRLIMKGGHIQEDNCLEGAVITNEHGRISESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IJB2</accession>
    <name>A0A6P8IJB2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione synthetase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116301865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031566889.1">
        <property type="nucleotide sequence ID" value="XM_031711029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116301865"/>
    <dbReference type="KEGG" id="aten:116301865"/>
    <dbReference type="InParanoid" id="A0A6P8IJB2"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031566889.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18097" checksum="B19FD126A70F6930" modified="2020-12-02" version="1">MKPIKRQRLVKXLTIAADDFIARIFNIYEQTKIEGIAQPISLGLVRSDYMLDVDQQADINQNKNDEQMSIKQVEINTIAAGACHFGSELPGLGSYVLGLMDKDIPEGSPKLPSNSALIGIAEGIAQAWEMYGNKRAVILMVTNDVDSAMFDQRPVEYYLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IKP8</accession>
    <name>A0A6P8IKP8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar complex protein 4 homolog A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116302389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031567531.1">
        <property type="nucleotide sequence ID" value="XM_031711671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IKP8"/>
    <dbReference type="FunCoup" id="A0A6P8IKP8">
        <property type="interactions" value="1833"/>
    </dbReference>
    <dbReference type="GeneID" id="116302389"/>
    <dbReference type="KEGG" id="aten:116302389"/>
    <dbReference type="InParanoid" id="A0A6P8IKP8"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="316"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031567531.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="61924" checksum="135763DAC74D785C" modified="2020-12-02" version="1">MADKKVNIALKQKEIKEKTKLILESSSNANLLVDLIESADTDDEEIILTFIKSVHKIFLAFLNDRKLMHGTKSSSHQASQEERETSGDKKTEDPEDVFNSWLYDKYLATQRKLLSFLHHVSVAVAELSLCSLMKFLVEEYKGRTHEKSAVFPAVLFAKIFEELVRGDYNMSSLIDRFSEYVEYDDIRFHLLKNIRKALENEEDFQRNGRFFKGNIHALLSQVKVPGDNDEINNFLVLENNLQGPEGKDSKPEVFLLKAHKKHFSKAWLLFLSKPLSPEIHKKVLLNLHTNVIPYMNDPKMLMDFLTDSYNFGGATSLLALNGLFILIHQYNLDYPDFYKKLYALLEPEIFHIKYQSRFFHLLDLFLSSTHLPAYLVAAFAKKLSTLVLSAPPQGAILAVVFIGNLLKRHPSCQVLIHRKEVSKLLLSGDVEENNVPSIESDPYNPKEPDPAKCNAIQSSLWELKTLQHHVYPKLPSFIEFFEKPLGKEDIDISKYFDSSYDDLFEKQCIKVTENNAILEYEQPKGFLGKNFDGFWSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ILU1</accession>
    <name>A0A6P8ILU1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium channel protein type 11 subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116302728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031567951.1">
        <property type="nucleotide sequence ID" value="XM_031712091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116302728"/>
    <dbReference type="KEGG" id="aten:116302728"/>
    <dbReference type="InParanoid" id="A0A6P8ILU1"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031567951.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="15051" checksum="BB90A069627A220C" modified="2020-12-02" version="1">MDEEQLYSYTRNSSNSVFKTNANSCKTAKNRDCVVRRPHSKDTTRLKRCPSQLLGRPLEDYDCSESGHDEPSPNTFIVLSRXTKNAPDQVQRFNKSKSLFLLGPEHPVRLFAIHILIHKYPYYNYILQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8INB6</accession>
    <name>A0A6P8INB6_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116303053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_031568359.1">
        <property type="nucleotide sequence ID" value="XM_031712499.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8INB6">
        <property type="interactions" value="1830"/>
    </dbReference>
    <dbReference type="GeneID" id="116303053"/>
    <dbReference type="KEGG" id="aten:116303053"/>
    <dbReference type="InParanoid" id="A0A6P8INB6"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="80"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031568359.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="63970" checksum="A1D7C167A09EBDDF" modified="2020-12-02" version="1">MEFEDCRSEASIGLENSISTVLGDDEQQCISLPQRNCSSPSGKRKRKQSSPPSSPSAIEGFGDSEAGDILKQFPELEEIFTVVRKVGEGTFSNVYLARVKKFPDELCALKHIIPTSGPERIENELRCLQTIGGRENVVGIETAYRKNDHIVFVLPYVPHQKFQDYYLELSVCEIRQYLKNLFIALKRVHSFDVIHRDVKPSNFLYSRQSKQYSLVDFGLAMPVPGSTKSLFASSKEKSITPKQTSRHPPRRSSRLSPQIENNQDNRKHLTTSSNIKHVLKPSITHSGNIRFASHSKNFKMPVSKSHTGSRIQLESKQTAIIKTHKMCCPVKHSQLEICSACMSRGHQNAPRAGTPGFRSPEVLLKCPKQTTAVDIWSGGIIMLCLLSGRYPFFRAHDDMTALAQIISVIGSSECIKSANDIGKDLILNAKFPQGDLKAACQRLRSGSCKGXTSGCIASDPSDGHDSASKRARRKSPTSKKNQSKDSKPHQRCSFCREAANPDSIVHHCPNSKWIKEGKDHEHLDGTKCSSDCCKCCWTIPSSAYDLLQRCLDLNPQTRITASQALQHPFFTEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQ40</accession>
    <name>A0A6P8IQ40_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">QRFP-like peptide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16" type="primary">LOC116303591</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569018.1">
        <property type="nucleotide sequence ID" value="XM_031713158.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569019.1">
        <property type="nucleotide sequence ID" value="XM_031713159.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569020.1">
        <property type="nucleotide sequence ID" value="XM_031713160.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569021.1">
        <property type="nucleotide sequence ID" value="XM_031713161.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031569023.1">
        <property type="nucleotide sequence ID" value="XM_031713163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116303591"/>
    <dbReference type="KEGG" id="aten:116303591"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="40"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031569018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031569019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031569020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031569021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031569023.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42728" checksum="9CFE8835E5E8F0FA" modified="2020-12-02" version="1">MDNTNNTTAEAMCTDPPINATAEWVKAVTYIILAITALIGNIIVIRVFTTSQRMRTEVNLLIVNVAVADLLIAVINMPMMVRYFVRAANHLPTIWFGGIFGEXLCKIVSFVSGVSQNCCILSMTAIAFNRYFAIMFPLKSPLNATKTKVLIAFIWLCSCAICSPVLYAMRILEVEGQYHCIEKWQWDEPLDSKNNVDAPKYYTLALFILMYVIPLVLITYLYSCVIHKVWIRHVPGNVTVANQRLEDVAKRRVLKMLITVVVAFALCWLPFHIYLMMVNFKYGIHSCEISPLMLFLGLLLGHSNSAINPWIYFVFNKDYRRNIKDLCSSPCNSQTYKTVRLYSHTTRCSTIKSTNGQTSGGKDIELQELKNNIDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IQX4</accession>
    <name>A0A6P8IQX4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleic acid dioxygenase ALKBH1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116303840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569307.1">
        <property type="nucleotide sequence ID" value="XM_031713447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IQX4"/>
    <dbReference type="FunCoup" id="A0A6P8IQX4">
        <property type="interactions" value="3459"/>
    </dbReference>
    <dbReference type="GeneID" id="116303840"/>
    <dbReference type="KEGG" id="aten:116303840"/>
    <dbReference type="InParanoid" id="A0A6P8IQX4"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035515">
        <property type="term" value="F:oxidative RNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="6">
        <location>
            <begin position="126"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031569307.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41629" checksum="4A364D613AF8D63C" modified="2020-12-02" version="1">MDAFMKAFKYYKQRKPPPDLSHVIDFETPDKYKDMVVPVSVSSLDDDRRLSSLGLRSGSEWEIFSVKDSPGFFFIKNPFLPGVQWDLVTRCLEVYLCKPNISNLDAHMEIKTSIWDSSQDSLDKKSPLYKLRWVTIGYHYNWDTKTYSPDNKSDFPQDLDQLFVRIANTLGYEKFSPEAGIINYYHLDSTLAGHTDHSEFDLEAPLFSLSLGQSAIFLLGGKSRDDAPVPMYMRSGDIMVMAGKSRLAYHAVPRVLSPPSDQKSIPSCLKPPCFDQSQHKLLSCPSKAMDTISTNEQSEHKTVRREAGELLTKRKNLDGEECASGVSLSLEKTETDLILQYLSCSRININIRQVLRTGQSFPVDRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IRT2</accession>
    <name>A0A6P8IRT2_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116303643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569080.1">
        <property type="nucleotide sequence ID" value="XM_031713220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IRT2"/>
    <dbReference type="FunCoup" id="A0A6P8IRT2">
        <property type="interactions" value="1510"/>
    </dbReference>
    <dbReference type="GeneID" id="116303643"/>
    <dbReference type="KEGG" id="aten:116303643"/>
    <dbReference type="InParanoid" id="A0A6P8IRT2"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031569080.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15442" checksum="C9E84D63ACDD35CA" modified="2020-12-02" version="1">MGRVRTKTVKKAARVIIEKYYPRLTLDFHINKRVCEEIAIIPSKKLRNQIAGFVTHLMKRIQKGAVRGISIKLQEEERERRDNYVPEVSALDTELIEVDPDTKEMLKILEFGSIPNLQVTQPITAAQTFRPANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ISK7</accession>
    <name>A0A6P8ISK7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane progestin receptor gamma-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116303838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031569305.1">
        <property type="nucleotide sequence ID" value="XM_031713445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ISK7"/>
    <dbReference type="FunCoup" id="A0A6P8ISK7">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="GeneID" id="116303838"/>
    <dbReference type="KEGG" id="aten:116303838"/>
    <dbReference type="InParanoid" id="A0A6P8ISK7"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF143">
        <property type="entry name" value="MEMBRANE PROGESTIN RECEPTOR EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031569305.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41262" checksum="004331BDD961DDD2" modified="2020-12-02" version="1">MGKGMNESKCMESSVENKARENHILLGKQDGNSQTEICRALRWDEVPCQFREQYIMTGYRQPYISAYQCIKSAFMARNETMNFWTHFVPFLLFLIRFGVLFMREPFDPYTYPLLSFAIGICGFLLMSSGAHLFNSMSPRRRHVCFFCDYSAISVYSVGAGMAFYSYGRPVHNGSKGWSFFSPGIYLSGSILVSFISTYFCCASRHRWAKMKYVIRTGCFVLAFFFNCSPYLYRVAVEGIDTIDPLAWSYFKRHSIFYLIAALANTSRMPERLMPGVFDIIGHSHNFLHVFTALGVSDQFTAMEIEMRHRRPSLERLGDSFLSQKSLILMILVSLANIFIVIWFAKGLKSDKEEEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IT82</accession>
    <name>A0A6P8IT82_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Nidogen-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC116304579</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EGF domain peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031570204.1">
        <property type="nucleotide sequence ID" value="XM_031714344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IT82"/>
    <dbReference type="GeneID" id="116304579"/>
    <dbReference type="KEGG" id="aten:116304579"/>
    <dbReference type="InParanoid" id="A0A6P8IT82"/>
    <dbReference type="OrthoDB" id="5953547at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF28">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="15">
        <location>
            <begin position="131"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_031570204.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35171" checksum="F355D3CF9D0C0760" modified="2020-12-02" version="1">MSQNPCEGKPCLNKGKCLLHKNRRDYRCRCKKGYTGEKCQHDIDECTTASPCHVNATCINIPGSYACRCNDGFSGDGFSCADIDECATNVHQCDRNAYCNNTVGSYRCTCNRGYYGNGIKCTTSRGLDFSAILSNYGNADYIRTLSGYLDPVLQSSSRSRWIRCWHAATDGWNTATIFHPQCDGKGPTVTIVRVGSYVFGGYTDVSWHSRWQYFSSSRSFLYSLYNTNGYSPVKLTLNGRDGNQHAIYGGSSYGPTFGRGHDLVISNYASNTTSSHTYMGFSYYAPPGCRNGGYECSTLAGTYGFTPNDIEVFYETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8ITF6</accession>
    <name>A0A6P8ITF6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116303975</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116303975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031569473.1">
        <property type="nucleotide sequence ID" value="XM_031713613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8ITF6"/>
    <dbReference type="GeneID" id="116303975"/>
    <dbReference type="KEGG" id="aten:116303975"/>
    <dbReference type="InParanoid" id="A0A6P8ITF6"/>
    <dbReference type="OrthoDB" id="5947728at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031569473.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18907" checksum="7C5E2BA4AAB18E88" modified="2020-12-02" version="1">MHRRLKDSDEPPYKPLGPKTVVKVLLIIFTCLGFSCMVVAHMAFGDDYTEAYQNRYILYFATHLIGMLESIIILAIFLAQLDLACGARRVFEIANVVMSFGLSILCGISAGLMFYYADKLYNNRLYDTDTEYWKWYTDHLLVAISVGILNSILFLIDATLHANAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IU10</accession>
    <name>A0A6P8IU10_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116304764</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116304764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570402.1">
        <property type="nucleotide sequence ID" value="XM_031714542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IU10"/>
    <dbReference type="GeneID" id="116304764"/>
    <dbReference type="KEGG" id="aten:116304764"/>
    <dbReference type="InParanoid" id="A0A6P8IU10"/>
    <dbReference type="OrthoDB" id="5988348at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031570402.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26027" checksum="9691B3DDE316C69A" modified="2020-12-02" version="1">MVSFLSNNQGKRRTRSSKSSTDSVGSPDSKKVKNLEKKSTEEHSTEENDEVLIALDMTKELCEKMDDVLKKLTKLDSIESAVTNIQTSLHKLEERTTNLEKSSASNKEDINDLKSAMAFCDGTVNNVKFEVDVLKKALESENSNKEELKLKVKDCGYYTGDQPNICKWMEPKTTQPSTKDIMNVLKLNFTMRIDVHKRIIEHAEILEADDQQLSNLMPPDAKQQIMIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IV97</accession>
    <name>A0A6P8IV97_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116305180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031570897.1">
        <property type="nucleotide sequence ID" value="XM_031715037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116305180"/>
    <dbReference type="KEGG" id="aten:116305180"/>
    <dbReference type="InParanoid" id="A0A6P8IV97"/>
    <dbReference type="OrthoDB" id="5968803at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="5">
        <location>
            <begin position="311"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031570897.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="54728" checksum="8691CBD7A2BECC8A" modified="2020-12-02" version="1">MASQIPLPEKLESKRPEAWKTWIERFDFYRIASELHTKGDAVQVSTLIYAMGGNAHEISKNFPLGAKDVTYKNMVKCFNDHFIGKTNVIYERAKFXRRCQLETESAIDFIEDLHKLAESCNYGDLKDELIRDRLVVGIRNDAXSEKLMSDESLTLDQTIKKWLEINILILHDLSDYNKQQTIKARESTDVRVATIHNKKQNSYRRSNVEHSSTQGNPQPKPKSSDKSCYRCGRSPPHQRQDCSALSHKCYHCQKIGHYASVCKANSVSAVEQDSDSDSSDSKTGKFLGEVRSQENTDSKWHVKLSIGDTDVTFKLDTGADVTVIPERVYNNARLKPLSRSNRKLFGPGHSPLSVRGVVKTQVTTMDGKSATTEVYVIDGLKEPLLGRPAIDSLHLVERVNEPKTSRFAVYSEKDLDNLVDESQAKSTKYATAYAVPVFKEWASSKGIEEEIANMSKEELNYNLKSFYAETRNKDGENYTYSGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IVC3</accession>
    <name>A0A6P8IVC3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC116304490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031570093.1">
        <property type="nucleotide sequence ID" value="XM_031714233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IVC3"/>
    <dbReference type="FunCoup" id="A0A6P8IVC3">
        <property type="interactions" value="970"/>
    </dbReference>
    <dbReference type="GeneID" id="116304490"/>
    <dbReference type="KEGG" id="aten:116304490"/>
    <dbReference type="InParanoid" id="A0A6P8IVC3"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="12">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="13">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031570093.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26934" checksum="5497091BDBC71A41" modified="2020-12-02" version="1">MLRKEEVASMRIDYKTEGFSEDDLVAKEPMKQFDVWFKMARESKDIQEANAMVLSTCGSDGQPSARTVLMKNYDDQGFTFFTNFTSTKGKQLMENPKACLLFYWPPLHRQVIIKGTAEKVSDEEATEYFHSRPRGSQIGACISRQSTVIPSREVLSEREKVLKERYADESIPVPKPDYWGGFLVRPESIEFWNGQTSRLHNRIRFRKLIPNEEIDSKLTKLGTNGWVYEMLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IXZ3</accession>
    <name>A0A6P8IXZ3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC116306403</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116306403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. Cappuccino subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031572316.1">
        <property type="nucleotide sequence ID" value="XM_031716456.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116306403"/>
    <dbReference type="InParanoid" id="A0A6P8IXZ3"/>
    <dbReference type="OrthoDB" id="427644at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF7">
        <property type="entry name" value="FORMIN-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="1179"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="804"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="946"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="871"/>
            <end position="885"/>
        </location>
    </feature>
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        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031572316.1"/>
        </source>
    </evidence>
    <sequence length="1619" mass="181521" checksum="E64D3BA0B987349B" modified="2020-12-02" version="1">MAELNSRVYDFKTFIDEYPLPQIVKVIEGVYGNEDELXLSALEVVHLHMVKNCDTVKATDERNREFYXPLNSPAKVKVLPNPIYQEFYDDVLKLAEDFPTYVEACDDDSELNIKMGDVLKLKRLTTNPHDDNYLICECTNKEKREILIPFSYRAKFKTLGDFEHSVLFLKEVVAKTPHFPVLVKFQDNLLKTSRRDINAGCPTGFNQLGAFSLKEAFVMKLVVATSCGANHGSKERTLLTIPHDLDIRVIPVLDKSERSAYQTEKLCRIGSFKINFNETSFRYGCNFIKKQECSLLKQGNTRKPIPRXRNRVTPDMTATSSGICDDKQTVNDSCXFSSCLDDETEKKGTCADDIDESAKTTTLINEKEDVYVDMSFCKDITPEVNFGESESLKQQQSKKYEATAAASGNGTGTGTVTAXXDDNDEEDGGGHGRDSSGSDDGKDGHLAKSNIPPLQFNNSRDITEETNDYDEVPVKQSQSASRPTSIVKNLRYDTNDNVFQSGHGHLGLPPFVPKQPSRYSTKKTKSKIRKKIENLKKISRSALKRSKSTTDMESSVDYHYVEPISEAKADKQTDIAKFLSRLQRSKEQGGKDFSXVDYLSTLTVDEVSESLKNLNLHRYVETFRANTVDGSLLMDLNDKMLDELEPKKFSHLPANDSKQSDKPAWLTPKLKSVSRAGGGSKALADLIQXDQNRLQKAKNERKEEEKSPPQSSFSGKAVFEGSSRTNRGTRDGIGAKIEATNHNGPTSPTHKSGPVSPTRKVQSTAVFTPQGSQNRXXVXNGNAEXNICFADRKKSLEREKXHRVTEARATSASSVRSPIVVSSKKVGQQNTEGTSPRTHPIADTPKSLTRKTSTGHIILSSPGNSNPNNPTRRDKPVYWRDKGKTNENQTTSQIGQEIQNHKISENIASNVGQRSGQNNNQRGGMITNVQSVGQDSQKHIRQGDMKTIAGQRPGQSHVQRGDTHTKGPQNNVIKSKTVSNNVTSNDCVTVEAEKQERDEKTVEQQEQKLHDGLEKENVVSATAVNSGNQKPRSKVWREKLQTNDLNPEPEPEMNVAEDRVEPQAVYHPTMPFNLDRAXDSSRADVDKLRQELENLKTEHESVVGMYKTTINKLKEELEEMKMMNSLMSEGQSIEPAAPPPPPPPCPPPPPPPFPGGAPPPPPPPGGAPPPXGSRIIRPRKGVIKPGVEMRPLFWQRILLTDDTADDQCSDGATKSRNTIWGNMKEAEFDIKEFQKLFGRKINKRKRANKRKSLHEDLIFDRPAGKQVXKVLDNSRSQMIGIIMTSLSCQLDDVKEAIYKMDTNTIDMDGLKALYHIRPKPDEIEVISKEVQDHPEATLDKPEEFLMRLXKMDHFSERLECWLYKDRFTETIHDVDRRLGAIGEANAHIRTDKEIHFVLSLVLALGNYMNGSTARGQADGFQINALMKLKDIKTQDNMMNLLQYIVQMYCKIREIKGPGAEYTLPDPYIVLAGSQSSFKEIRENMAQAKITLATCKAKFWICFFSAEVELSRLSEKHETVAGEFKKITDYFVFKAEQGEEVGPPYFYGIWGHFLEDFKNYWKAEVLQIAKKKFSKTEHLQQIKAMATQFINRRGSSSKDDVEQAKAAVAPNKVSSVAWCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZT7</accession>
    <name>A0A6P8IZT7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116307069</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116307069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031573071.1">
        <property type="nucleotide sequence ID" value="XM_031717211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116307069"/>
    <dbReference type="KEGG" id="aten:116307069"/>
    <dbReference type="InParanoid" id="A0A6P8IZT7"/>
    <dbReference type="OrthoDB" id="5951371at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031573071.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30956" checksum="CD2ED20854866305" modified="2020-12-02" version="1">MDMAMSGEFENTAIQTRPLKIEDEKALRRFQDIAQYFLKNTGEGKILYKSGVKNNYQWRSICYASQNFRAYYALELFGLRSELSCQAFKTAIEKEIFNKELFRDITKVTSLGCGPGAEMWGFKIFCDEILPYSSNCSNGRKTSPRFMGYDSELGWMPFVESLDFEFVNKELDATALRNMMPTDVIILSYFAKVAKINIDSPQVNSFWEELERKGNIIVVIEMVDENLHQILQRRGYSSFTIFDKIGNQAQVHCLHQTDXAVLRRSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8IZY3</accession>
    <name>A0A6P8IZY3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC116305506 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC116305506</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2 3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571299.1">
        <property type="nucleotide sequence ID" value="XM_031715439.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031571300.1">
        <property type="nucleotide sequence ID" value="XM_031715440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8IZY3"/>
    <dbReference type="GeneID" id="116305506"/>
    <dbReference type="KEGG" id="aten:116305506"/>
    <dbReference type="OrthoDB" id="5987939at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031571300.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21029" checksum="DF6C8B3804493508" modified="2020-12-02" version="1">MAYACPITITKHPVIAKSMILITFCIPRTWSTKLDIRMLEQKGGNRWVATRIEDIAHCRFISDKLNSIIQQEVSKECLKSAKKKAEEKGFEYFGIQYKTECWGSPNGKEITYNLHGCKNNCLRHDDGFGVGSDWSNFVYRLKKDWSDCKDGFKYKLVSKQGTGYECPLYNVKIEKSATKREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J084</accession>
    <name>A0A6P8J084_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116306865</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="RefSeq" id="XP_031572849.1">
        <property type="nucleotide sequence ID" value="XM_031716989.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J084">
        <property type="interactions" value="3511"/>
    </dbReference>
    <dbReference type="GeneID" id="116306865"/>
    <dbReference type="KEGG" id="aten:116306865"/>
    <dbReference type="InParanoid" id="A0A6P8J084"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000172">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="G_DYNAMIN_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
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            <begin position="22"/>
            <end position="331"/>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51388"/>
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            <dbReference type="Proteomes" id="UP000515163"/>
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    <sequence length="743" mass="83619" checksum="5E36F739B986291A" modified="2020-12-02" version="1">MEQLIPVINKLQDVFNTVGAESIQLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGVVTRRPLVLQLIHVASKTKPVKKSQKDSEKEELKAEENAGDKFYSDDNEDDXEDGDEKEPEEWGKFLHLKEKKFSDFDEIRDEIERETERVTGVNKGISNEPINLKIFSPKVVNLTLVDLPGITKVPVGDQPHDIEAQIRLLILQYIRNPNSIILAVSPANIDLATSEALKLAKEVDPEGHRTLAVITKLDLMDHGTDALEMLYGRVIPVXLGIIGVVNRSQLDINNKKSIQKALRDEAFFFSKTYPTLASRNGTPYLAKTLNKLLMHHIRNCLPELKSRVNSMISQYHHLLQSYGEPVEDKGPYLLQLITRFAASYCSIIEGRAKDIETSELCGGARISYIFHDIFGRTLTNTDAMEGLSTRDILTAIRNATGPRPALFVPEISFELLVKRQIRRLEEPSLRCVELVHEEMQRIIQHAFQQVLEIKRFPKLHDSIFEVITDLLQRRLYPCNSMVENLVSIELAYINTNHPDFTDGTLLVSTVVHSQEXERKRRLAQNSLSNGPLEGVKSQTSTPVGSPVXGARAAERQEELNPNNPSNSVPVDSSGGGFMSWMPSIRSSKSADQSDAAKQVPAVQDFPAALRQRGLTDREQMDSDIIRKLIISYFVIVRKSIQDSVPKAIMCFLVNFVQERIQSELVEKLYKSEKFDRLLEESEHMHIKRKEAAEMLKALQRAGQIIGEIRDTQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J095</accession>
    <name>A0A6P8J095_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC116305772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116305772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031571608.1">
        <property type="nucleotide sequence ID" value="XM_031715748.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A6P8J095"/>
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    <dbReference type="KEGG" id="aten:116305772"/>
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    </dbReference>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031571608.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27525" checksum="312652A4E74A6106" modified="2020-12-02" version="1">MWKFKMASGKKQSEADLKARESALNDLVLNFGFPKEQADKVLTECHNNVDHARERLCKMYGKSPASGPSCVPPNEPPPPYSECASSPISNPPLYISQEKEALLKNVEERFPVDTEERCSSCFDPIKPDPEEGFSGKMIWQGTKAYHSECYMKSKGPKCEHCCFALIAHPSKGLSGEWGIYDNKKYHEECYRQFAGPRCSSCCDVIAPNSEEGFTGRWIEDHNKIYHEECFAKKNFVEARAKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0R2</accession>
    <name>A0A6P8J0R2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NAD-dependent protein deacetylase sirtuin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116305658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
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        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
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        <property type="nucleotide sequence ID" value="XM_031715615.1"/>
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    <dbReference type="FunCoup" id="A0A6P8J0R2">
        <property type="interactions" value="722"/>
    </dbReference>
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    <dbReference type="KEGG" id="aten:116305658"/>
    <dbReference type="InParanoid" id="A0A6P8J0R2"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="10">
        <location>
            <begin position="55"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031571475.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="50975" checksum="3EF9B512D41B1E0F" modified="2020-12-02" version="1">MKNIDNDGASSKSGSQASQGTGTTEENKHLNFLQQLLARFRVAAPEEEEKEKPEQLLEEVTFEGAAKYIKSEKCKNIIVMTGAGISTAAGIPDFRSPGTGLYDNLQKYNLPSPQSVFEIGYFRENPEPFYMLAKELYPGTFKPTISHYFIKLLENKGVLLRNYTQNIDTLERIAGLSSENIVEAHGTFHSAHCIECRKEYTQEWVKDKVFKDKIPKCSACEGIVKPDIVFFGESLPKRFFNLVDNDLHKCDMLIVMGTSLVVQPFASLIDRVPLTTPRLLINREKAANRGDMWGILMGTGGFAFDEEHNYRDVAWLGDTDDGCVALADLLGWKDELLSMVKTVHQKIDEEIALHSDTPETKQPTASSETSTGTNQTQVAKDSPSSPEKTDQGVEETKDDLDKNTDPETQEGQTTDEQTEDAKEGGENPGKSNVTDTVSIRETSATSPTGDEDPCLDNPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0X7</accession>
    <name>A0A6P8J0X7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116307156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_031573167.1">
        <property type="nucleotide sequence ID" value="XM_031717307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0X7"/>
    <dbReference type="FunCoup" id="A0A6P8J0X7">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="GeneID" id="116307156"/>
    <dbReference type="KEGG" id="aten:116307156"/>
    <dbReference type="InParanoid" id="A0A6P8J0X7"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="91"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031573167.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32410" checksum="7413C9B09FCF54A7" modified="2020-12-02" version="1">MASFIHRILPKKGSDLAAFVFMFVMLWVIALFELFVVLPEFHEPFSPWYLIHVVCGLFLFLNVFSNLYQVIMTDITGANLALPSVLKPGWTYCPYCQMNAPPRAHHCHACNVCVLRRDHHCIFAGKCVGHSNYRYYLFLALYLWLGALYANIFHWQYVTSVIGTFGWATMFTMFMPMLSWMVGHTTVFQTFVTFMAGISLFAFVMFSFLLFFQVNIISRGQTSYERKKKKRLYDKGVVDNFVEILGKKWYISWLWPTVPSTLPGDGTNYTQLTESMKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J0X9</accession>
    <name>A0A6P8J0X9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Fibroblast growth factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116307434</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573550.1">
        <property type="nucleotide sequence ID" value="XM_031717690.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031573551.1">
        <property type="nucleotide sequence ID" value="XM_031717691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J0X9"/>
    <dbReference type="GeneID" id="116307434"/>
    <dbReference type="KEGG" id="aten:116307434"/>
    <dbReference type="OrthoDB" id="5986928at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00058">
        <property type="entry name" value="beta-trefoil_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056378">
        <property type="entry name" value="Let-756-like_FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044653264" evidence="2">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031573550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031573551.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="22233" checksum="4E7B13A845BB1154" modified="2020-12-02" version="1">MNRVSMLVLFVMATLIRCRGTTIARRPNMSKTPLPLRSSFQNISTQATVNETSRVNRPCIQDTLLPPSFKGLRKIWSEHKYVLQINANGAVNGTSDMASPYAQLELESLGKGLFRAKGVTAKRYLSMDRLGRLYTRKIPSLESVFKKIPADKGFVAYKNYVHCWYIGLKRNGQPKRGNRVHKDQHSAHFLELQGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J312</accession>
    <name>A0A6P8J312_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tolloid-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116307846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031574022.1">
        <property type="nucleotide sequence ID" value="XM_031718162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J312"/>
    <dbReference type="GeneID" id="116307846"/>
    <dbReference type="KEGG" id="aten:116307846"/>
    <dbReference type="InParanoid" id="A0A6P8J312"/>
    <dbReference type="OrthoDB" id="5964477at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF40">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027880147" evidence="6">
        <location>
            <begin position="35"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="44"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="176"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="308"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="445"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031574022.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="76573" checksum="FA659109E81CFFB9" modified="2020-12-02" version="1">MKCSEGICWVSRHFIAIAVLFVVTQSLLQYEVVAQESDSDLPICNRSQNFFLLNSSTTTLQNFSSPNFPADYPTYSYCIWVLTAPIGKLVKLVFSSFSIYSPSASNSRDCPYAYVKVTEQDKQGNSQVVGSFCGNQPPQTIYSSGGSLRVEFKNTFRASAKGFVAKYAAIQPGTACSEHNSLDENTNILLDASTGRIVTPQFTDSFSKAIDCTWKITLPPKNGVNMSFHAFKPKKQVPCSDAALEVYNGRYGRGHGAQLGVFCESSVLPVIYSAGRYMSLRWRGKNPESAIEFEMDFRSIQQKVNGSCDQMDRLRSVVRLEGVAGSIFSPGYPEEYPNNKECAWHLSVPSGFNIRLKFLTFQLESSGNCKSDFVEVRDGDSPTSPLKNAFCGSSLPPVLISKGRHMYVSFRSNFASSGKGFLAVFESTTEAPKTITTPWVQPGICSPDYTSTVNNNLKLSGSSGVILSPLYPSQYPNSISCTWKISVPDDKRIRLEFDDFWIDDQRGCHGDYLEVRDGPGTSSPMLGDKYCGNKNPGEIYSTGSSIRLQFVSDASGTSHGFKAKYSAVSKPFNRFIAVGIAIGAIVIVLIAILIYCKIKKKRSKDLEDDIEDFEDGQGTIDSRQAETPGNPLLSNGAETHHNNATPNDRYSVNYEPRPVAMETLLNDQGSIKNDLTEEECAWFKPSKRKSKGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J3J4</accession>
    <name>A0A6P8J3J4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm-associated antigen 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC116306643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="2">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031572583.1">
        <property type="nucleotide sequence ID" value="XM_031716723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J3J4"/>
    <dbReference type="GeneID" id="116306643"/>
    <dbReference type="KEGG" id="aten:116306643"/>
    <dbReference type="InParanoid" id="A0A6P8J3J4"/>
    <dbReference type="OrthoDB" id="2120499at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026124">
        <property type="entry name" value="Sperm-assoc_Ag8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15510">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15510:SF5">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22584">
        <property type="entry name" value="CFAP143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_031572583.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21815" checksum="EF8E0A363E497C4E" modified="2020-12-02" version="1">MTDSISAIRHNSNGKTLLDNWVEERQSAQFEDPNATIPTLQRHGHRGIMTTEFEAKAEDLTTVRDSYREPIELGIRTRGTKEEHLRNKLMAQVAAELEEELNPPPPPVELISTTHKDFNKEFEPFIKEPTRNHDVNKDQSLSFWLERHQEIHGVSQVKTQDTPFRKNASFSTPIGEYLDAPKPGEQWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J4Z9</accession>
    <name>A0A6P8J4Z9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease domain-containing 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574734.1">
        <property type="nucleotide sequence ID" value="XM_031718874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J4Z9"/>
    <dbReference type="GeneID" id="116308455"/>
    <dbReference type="KEGG" id="aten:116308455"/>
    <dbReference type="InParanoid" id="A0A6P8J4Z9"/>
    <dbReference type="OrthoDB" id="5967827at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039015">
        <property type="entry name" value="ENDOD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472">
        <property type="entry name" value="ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN ENDOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472:SF7">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574734.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22058" checksum="5C262147162A240A" modified="2020-12-02" version="1">MYKDNTQNIQKGHLVPASTYSFDCIYMVSTFKYTNAVPQYKSFNEGPWKVYEDRVRLFAASVCYPAGGDLYLLTGTSEAVLTAHGFPKQPDPLTYFPHNNPTRWDNIVIPNSMWTAGCCILRNGGIVGGFAAIGNNVQVNSEMHQKKVAELQDILATGIGGVGATINLFPGNEGCSKNLQQFRYEEGGTHPGWTKVIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J5Z2</accession>
    <name>A0A6P8J5Z2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein c-ets-2-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575147.1">
        <property type="nucleotide sequence ID" value="XM_031719287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J5Z2"/>
    <dbReference type="GeneID" id="116308798"/>
    <dbReference type="KEGG" id="aten:116308798"/>
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    <dbReference type="OrthoDB" id="10042983at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08536">
        <property type="entry name" value="SAM_PNT-Mae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PNT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575147.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25090" checksum="C7F4A0FDE40F5610" modified="2020-12-02" version="1">MNESVVIRVLIDDGTPRLPLPFRIQLSLTGLRFKQMIEAQEGFGVSEQELYFQNIQLVDNLTLGQQGVSDESHLDLRVNFQEIPSPTRKKGSTSETEDCVVPDIDDEDNVFNFEQPRVPPDPRIWTKWEVLEWLKWASERYNVRDVTADKFLMNGKGMCMLSLEGFMFRVPRGGDALYKDFHRRLTAAVEQSRHLQSLMNRSRGHSSPGPSNFYYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6I7</accession>
    <name>A0A6P8J6I7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC116309021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575407.1">
        <property type="nucleotide sequence ID" value="XM_031719547.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031575408.1">
        <property type="nucleotide sequence ID" value="XM_031719548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6I7"/>
    <dbReference type="GeneID" id="116309021"/>
    <dbReference type="KEGG" id="aten:116309021"/>
    <dbReference type="OrthoDB" id="5954753at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="455"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031575407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031575408.1"/>
        </source>
    </evidence>
    <sequence length="728" mass="83155" checksum="CDC83C7FFD2FCEA1" modified="2020-12-02" version="1">MNAYMMLGNAHLYKKEYDNAISYSTKFLAIAKESGDKVVEMNAYLMLGNAHLKNEEYDDAHRFFAEGTTIARQLEDNLDVSYFELRLNGIYEMVGTSERYSGLLPVGSFLKEFPDDVPDIERFANSFYRYVYYNANNEYEEAISCLETCMALGENSINKDDYLELLWNCKHDISELHVLLGDYDKGIQYQQEALHDARKEGSNSKQAKSHLSLGEIYYKLKQFVNAEESFKESLRCYELIFIGLKQNDRFKIAFVDQHKETFKLLLKVLIETNKKEEALLLSDHYRAKALKDLLVSSYGMKKEQTADEGLQYVDVQSLVSSSNYTLLFYSTCFEDLYTFVVEAGKELGFLVQHIEYCDSCLDKLVDKTFDYMKVREVINCEDRSIDVMDDYEENKNPKEDELTQLLIQQREKGLLEQCRSICKFRGNPSENSDKSSLTSGLEIFNQKLINNIKHLIKQDEMVIIPEGPLCRLPFAALRDPDKGQYLCERMRIRMAPSMASLKLLQEYPVEHHSRKEALIIGANVVDPVMLDGVEKVFDFLDGVIEEADEIAKMLGVQPLLSANATKPVVIKRLQEGVSVVHIAAHGSLEKATIVLAPSPEIRETKIPEEEDYMLTMADVQQTQVRAQLVVLSCCHSGRGEIKAEGVVGICRAFLASGVRAVVGTLWAIDDKATLMFMKKFYEYLKDGKSASTSINLTMNDMRKTPQYSEPKYWAPFFLMGDDVTIKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J6M3</accession>
    <name>A0A6P8J6M3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-5A-dependent ribonuclease-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116309027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031575419.1">
        <property type="nucleotide sequence ID" value="XM_031719559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8J6M3"/>
    <dbReference type="GeneID" id="116309027"/>
    <dbReference type="KEGG" id="aten:116309027"/>
    <dbReference type="InParanoid" id="A0A6P8J6M3"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031575419.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43440" checksum="216E2BC652EE5CB1" modified="2020-12-02" version="1">MSLLMAVKCGRIHQTRLLLDIGTDPNISTDKDSKTSLMQACFIEKQNIAAKIARMLIDKGAVVSTKDRFKRTALSYACMNGKEKIVEMLLEDIEYDINEQDEEGNTPLMYAAMSGNAKALCYMLKKIMKYRLSVDLRNKKGFSAYLLAAKMGHFYCAHILKTEGFASDGIRDTEYFLSDKEWIKKVRRDISRMQLDGDDIRIMGSRSACTRTPRVSLTSRPKTSLDFIDRLESPSRHNYTRRTVTDSRLDSRTGSRITARNETPHMTKNSWIDIADGRRSRVTSATSSNSENSLMLVSESSDATEIVPCEARTKTPDLHAILSHYLDKEAYKPVKMIPRKGRNVQFSKEARTAPSAGKSAQSTLRQRKQSRQSPKPKRRGVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J7N7</accession>
    <name>A0A6P8J7N7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC116307107 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC116307107</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031573115.1">
        <property type="nucleotide sequence ID" value="XM_031717255.1"/>
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    <dbReference type="KEGG" id="aten:116307107"/>
    <dbReference type="InParanoid" id="A0A6P8J7N7"/>
    <dbReference type="OrthoDB" id="5958059at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019955">
        <property type="term" value="F:cytokine binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="FA58C"/>
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    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
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    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
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    <dbReference type="InterPro" id="IPR003961">
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        <property type="entry name" value="Galactose-bd-like_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
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        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050379">
        <property type="entry name" value="Type-I_Cytokine_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23036:SF151">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00754">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07885">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="10"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="10"/>
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        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
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    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3779"/>
            <end position="3799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3845"/>
            <end position="3864"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="4024"/>
            <end position="4042"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="482"/>
            <end position="627"/>
        </location>
    </feature>
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        <location>
            <begin position="658"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="16">
        <location>
            <begin position="936"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="11">
        <location>
            <begin position="1250"/>
            <end position="1409"/>
        </location>
    </feature>
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        <location>
            <begin position="1531"/>
            <end position="1688"/>
        </location>
    </feature>
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        <location>
            <begin position="1704"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="15">
        <location>
            <begin position="1783"/>
            <end position="1970"/>
        </location>
    </feature>
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        <location>
            <begin position="1976"/>
            <end position="2196"/>
        </location>
    </feature>
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        <location>
            <begin position="2643"/>
            <end position="2738"/>
        </location>
    </feature>
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        <location>
            <begin position="2741"/>
            <end position="2835"/>
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    </feature>
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            <begin position="2837"/>
            <end position="2934"/>
        </location>
    </feature>
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        <location>
            <begin position="2939"/>
            <end position="3036"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="3039"/>
            <end position="3150"/>
        </location>
    </feature>
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            <begin position="3154"/>
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        </location>
    </feature>
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            <begin position="3252"/>
            <end position="3346"/>
        </location>
    </feature>
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        <location>
            <begin position="3351"/>
            <end position="3445"/>
        </location>
    </feature>
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        <location>
            <begin position="3450"/>
            <end position="3543"/>
        </location>
    </feature>
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        <location>
            <begin position="3548"/>
            <end position="3652"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_031573115.1"/>
        </source>
    </evidence>
    <sequence length="4126" mass="461361" checksum="B9CC15B328259EA4" modified="2020-12-02" version="1">[encoded data, 4126 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8J9P6</accession>
    <name>A0A6P8J9P6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 13B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116308234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574473.1">
        <property type="nucleotide sequence ID" value="XM_031718613.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8J9P6">
        <property type="interactions" value="1634"/>
    </dbReference>
    <dbReference type="GeneID" id="116308234"/>
    <dbReference type="KEGG" id="aten:116308234"/>
    <dbReference type="InParanoid" id="A0A6P8J9P6"/>
    <dbReference type="OrthoDB" id="445152at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="2">
        <location>
            <begin position="1844"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574473.1"/>
        </source>
    </evidence>
    <sequence length="3288" mass="364701" checksum="4B32DA68C5FA9F38" modified="2020-12-02" version="1">MEIHRNNPMYPTELTKLIIANAEFPASKSMLHHAFNNTVIQVFNIEMYISHTIPESALINIMPSVSAILSVKDCILPDTWKNETLKRTEVHLEVPSISLSLTKAQFLLLSHLFASWSTMWMQNKILPVLPTTVIASTLDFHSNNSQSELELDMSNIDIQCCNTSVVMTTTSSVGTISATIKSKGATRLPDSEEKRTAVTQIIKGPCDTKEIYKGTLFNNSTYHEDEVENVGPVISLTLQLPRYMEKKDIKSFQGYLHNTEASNVVLLQAKGISVCCDPLLYSWLAYQPSASSSSGMRKVEKDRRIRXASLVRTPSIGTPRKKSYARGSISSPSKGKVPQERSTESKLENTDGLTFEAWLFEKLPLITSFAVQVDIQSTLIFVPESPISQAPHVSSIAQNFAYQSWKGKSAFPSTLVVCLPSLEIFSASHIKVSFRPSLPVHLCKQTAKDSIKHDTLPWTMSAKNLAVYSVHLQSNHFDKTASPVCYYIVSPLSCTAVLASAKTSTPSSPTNLSLLLRSGSRAHEGTSRRESQKSPMLGFCIHADFEPLIVSTSRKQIKLLANLLESFFLAVVSPSSRSIEFCPPIPDSTSQRRMSVTSSSSTVEHIEKESVLSPSESSFSFTQIHQSLQDVKVSLWLQWTLPRFIVKLYNNMPSGSIPVCVTMDLEDLTAFIDYQETHLQMQYKVGAFNITHTMKRDSTWLPGPFGGILLSCKDILTYKNPPLVTSQRIPSTANQHEGPASGPHGFFNITYNRSSLHLKRKHSYSQKSGKEPSIEECLKIQHEVCLSVQPFDVVLWSPIIVAGIDVFDASLLCKFKFPSRENSKPFFDVDKEAKDGNDNVTLSVCLLPLLFMNMRDIRLFLPCSEITQIASSSESLHEDLVIVHLSAVTATPHPENPIGRTVLNEDLYEKFKKFGRSSRHALGYEVHEIQYQMVFSGFGVWTTKWKELCGNLNKQGDVGSSPLMDQNPALEWNTQLWRSAKEVHVSPVLTGSDFKIVIAPATTMERTVADARNTSKSFTDSIPVCGCSMELNLVTNVDIFLSKCQMQLLRTLTLENVDAFYSCELMSSLSQGILGNADFKIASQDGDHIDSGLGSTHTDPVKPSQKAIPFEAFLAARNITISMYLQRALKCRRNQHGLTVPAKEESPVYALSTKPVLQIGFLQPSVTYKDHALGPHLKLWCFDMSVLGSLAQVQHQGWLPKSLPEFSDYSIDCFSTGSGLPDPHTGIMPPLLTVDARNLTNGAMNASLDLGRPIHLSFNPDMVLEITRFFDDFIVHQSVSSAPTPPHKSPQEASTENYSALKFCNLTTHDISLELSLTTRDDCPKVLLGMTGGRGSIRIKCDEQGIFQRLDGNVETEGMEMSFLAYAQSFYLVRPFILKCEFEIISSPHSLTPIIPSLPQICSRVSIGLLRLEFGQQHMNCIAALSKALQEFSSXHSSSANTEEMQVVMTNKQIDIKNDNDKVVGLTSVRAEADLGLDEQDVDNTYGKNDVKEQDLDGVKQTFDDLRAGPFKYVMVSGEVGLHHPESYEILFTTDTRERPPTMVWRYPEPRALSSVEVLPLPFTSPVLVNTLNMGDELRVPCVLSYWDTLQKCYIVYKXFYISETSSCKISLPDPLRSDPATVIVAKEWQMIVDASFEIDYSEDQSLVDEDSGSSYSSPYRSLISATSLAASVKVDSVFSPSLIPXVLAQVSISMFQIKLLHHNQYSHQVLPKHLAGYTIDSSVPTEQEFCTLTIEGLSGVTKHLGGGNAVTLCSYEWNCHFELLDFGDLTYRTLVSPFSISVTTAFHXKGREAIKTADQRSVCLEAGVDIGNIEXVVTQSTVHTLALAVDSWTRDDKRKNETTLLCHYIICNDTNEAIRLGQVDTDESILLSSKHLLPYSWRVAQSLKAEPSLHVCFEREGDWRWSEPFDVDSVGISSRTIHHKLHSATLLIDVRSLSGVQKQVIFRGGLQIESRLSTGVDLQILKSPDLGSPHKEKASFQIHEDISLAPVTTLPSYIVSHAGLLGMRIRIPNTTTWSEALPLDNVGGDAKAQHLIXKLLGVKTFQTFYLWYSLEKTMFEQIQISLSPLFIMRSHLPDPILLNIFSSKTNSEASLEMIGRGHEEQLLHLPPNTWHHLTFQFDKCSKMSDPSVPLNSTLIDLANKVNPNMCDKVDIPLNTLWPYCGTILKEKDEISSVSAAHSPFVRYVVSRGNDKDANSYQKRAEISPKVSPFPDVELQCRVIKKWHHLNTLLVDVTPWCLLINKTVSTIFIKDFEDKGEIQMPSGQTIAPFKFKGKIQFGILVTGSSTISWSKPLSLPISNDEMKDLSAKEPNTPDESNHATINIAHISTSSRPVAVVWTMTSQTRHGVRVISVQEKFGFVNSTGKPLLVLPVLAAKVKKIPSDVLDIERAIQLPIDSKIKLPVAYWDIALTSSVVIDKEEVASVDDTFPVAFFALGEQKFQSNIENQDDNSIKLHTESLSSQWSQVFLMNSDLPRSAIAIPVRDSRTTIPLVMTPNIVSGITNIVVANDSSPRLIFYNDCPFTLQFGQATPPQSPSYQKGSLDKVIVVEQLEPFYEVPKIPALGMTHYELTIMREWFKTSSEFQEIPNIHIQALYDVTVAEISEGAEGRISHGQTTEVPQGWSHGFDINSKGHFVVNLPGRGRVIVFVSKSRLCTAVRIQIYDKDAVAMELPSNEVLSPSFDVAMKISKLEISLIDARNQRKPSEVLRTAILGINLCNSPLIEHSDGNSVFSELSLTLNSFQLDNQLEGELFQFPVVILANESFPKLSNASSQRKPRVGTCLKPFLSIKIKYEPNMEKTFLHSVLVSCEPITVFLEDTLIYRMALLAESFLPPAQEYDLLADSSFLETTLLLNECSSILNPLVIGKFDIEPVTIHLTLHASVKLFIGMDDTSLSLGHFHMSPVYAPTSAFAQKVLFHYMSSVMFKIGWVVGSLELLGNPAGLIRNFSQGLSDFFFLPYDGLTRGPGAFVSGMSQGVSSLVRHVSAGALTSVTNLASGISRNLDRMCMDEDHLRLLEEQRCRRPTRLMAGVTQGLSGFGLSLLGAVAGVVDQPIQGIQRANDVKEAAYGALTGVGRGLLGVVTKPIGGAMELVSQTGQGILLEAGLSHLPSRLHTVEDGLVIESRNSLLKYSWKVLQLKTNANILCVDVTVVNTVGHDYSGALLLTNNMIYITDTDTDAIQQSFHLRNTVLQKDEXDNRTIIVTSVLQANSFDDYASDNPEPTGDPERMEQFLRDAQMFAQVSQADSSTDHSAESIITSNLKLIIDPILRDSVISRFTTAKYKVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JAQ6</accession>
    <name>A0A6P8JAQ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC116308514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC116308514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574813.1">
        <property type="nucleotide sequence ID" value="XM_031718953.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031574814.1">
        <property type="nucleotide sequence ID" value="XM_031718954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8JAQ6"/>
    <dbReference type="GeneID" id="116308514"/>
    <dbReference type="KEGG" id="aten:116308514"/>
    <dbReference type="OrthoDB" id="5818871at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38553:SF1">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38553">
        <property type="entry name" value="PROTEIN CBG19621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031574813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031574814.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39754" checksum="EA892A358A6F371E" modified="2020-12-02" version="1">MVAPTNISDALWHSYAYTGCFGTFNTMSCVRDSTLTCLAFFTCLICIFKVVKLHRHHHSLPNQYIIYYSGIVNCILCGLNWLYLAKTPVLLVTQFLKTSCQILTVTHFHCLLAARMTRREETFKLFNIPIMFVLLMYMLVTVIVGLATMKSEFNECKEPEWLLLSSAEFFIVQFFLVAGICISRELNVVRMQENNRASQKRDLWGIIFVFEISAMASLIHDIVMRITGPSNSCQGVFLNTAAGYTAVYITVKIIRWFLPLWAIAIIFGIEANHEMVERQPIYITPGNSGNFTSAFRPRGTSFNYKHLYDDPPPAERPLISPYGSSSGGMDAYGSFGKSPKDLRSGQTYPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8JD38</accession>
    <name>A0A6P8JD38_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116308202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116308202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031574445.1">
        <property type="nucleotide sequence ID" value="XM_031718585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116308202"/>
    <dbReference type="KEGG" id="aten:116308202"/>
    <dbReference type="InParanoid" id="A0A6P8JD38"/>
    <dbReference type="OrthoDB" id="5959890at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031574445.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28871" checksum="9D1E305F56E2CF03" modified="2020-12-02" version="1">MDSHKSDQGFRESKEIRKLLKLKDSKVGNVILKSNVFEQAKLGNKLDKISHHQRSQEVNLSWKKHLLLRKQRSTLLKSKSTSSIMIPPSQLPRLLPPIKMKPNTFSHQQIGTGLTGHTEEDRFHSKRHGIPMDTSGTEASGELREKNLCPKTKSSEKALLQWKRAIKKTRERIQXSKRKLPPLVLQKSQLDYEKDPRFARLIEQLVPNMSRRISDGDIRHKNEDVDDDEEDTDISHENGDHEDEQYFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYN5</accession>
    <name>A0A6P8GYN5_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116286878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549324.1">
        <property type="nucleotide sequence ID" value="XM_031693464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116286878"/>
    <dbReference type="KEGG" id="aten:116286878"/>
    <dbReference type="InParanoid" id="A0A6P8GYN5"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF182">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="451"/>
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        <location>
            <begin position="463"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="512"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="545"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="586"/>
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            <begin position="644"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="675"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="717"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="776"/>
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            <begin position="1"/>
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        <location>
            <begin position="51"/>
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    </feature>
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            <begin position="68"/>
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    </feature>
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        <location>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
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    <sequence length="836" mass="94696" checksum="E921AEAB1ED548E5" modified="2020-12-02" version="1">MSNRDHRGSNSDVFYPEEDKKPXTPSKSMQGLEHILHSRAVRPPSQGGGRLPSEGRGGRPPSVGNSRPPRDDRDWEPRDRDRRNSRSRENRPSSRDYDRAPRDSDDRPRNDRRPRDSRPSRDYGPTRQSRPSRDGRPRDYDPYPSRNERNAYPRHERPIDGSRPPSYEPPRSDTPYRTSRDNGPPPNYQGNKDLSLRVDKSTDALTPENSKGLYKPKEWSKPEKDELTVVEDDETTPRETWGHKAEFILATVGLAVGLGNVWRFPYLCQKNGGGAFLIPYVIFMLIEGLPLFFLELSIGQRMRKSAIMCWRDIHPCLFGIGVGCLMVSLMLCLYYVVVIAWCCYYFFISFTSELPWKKETLCHNWPAYNNILQAIKACESGSNPNCTTNSTLYLTLKSNESTFPDCCVRDPPQYYFYHHALQISSSIEDPGIGINIKLFGCLIFAWIITYLCVVKGIKSSGKVVYFTATFPYIILIILFFRGVTLEGAGEGLKTFFTPKWDLLLDANIWKDAATQMFFTLSLGFGALIAFASYMPIHNQVMRDAYTVVFINCGTSLFAGIVVFSILGYRQIKTGIPADKVGSGPGLAFMTFSDAMLLMDVSPLWAILFFFMLILLGIDSEFGTLEAAIGPIIDLKLFPKVRKEFLTLIIAVILFLFGISMVSGPGFYIFQIFDDYSVTIPLLVIALFQCIGVAWVYGNNRFADDIEFMTGKRPWVGWMICWKYISPIALFVVLVALVAQQAQKPPTYSKFVGCEQKPFGDNPGTETWTVKAEYPGWAVFLVVLIVLVSTVPVLIWLIKDWPKNSARSFHRTFCSGLNNYAPDPKKDPSEQTRNPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GYR5</accession>
    <name>A0A6P8GYR5_ACTTE</name>
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        <submittedName>
            <fullName evidence="3">FK506-binding protein 4-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC116286911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="3">Tentacle</tissue>
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        <location>
            <begin position="1"/>
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            <end position="30"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="90"/>
            <end position="101"/>
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            <end position="117"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031549364.1"/>
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    </evidence>
    <sequence length="150" mass="17162" checksum="A9C80E91136482D2" modified="2020-12-02" version="1">MAASLPFVXTIDSDEEIEPLDEDNDSEEEELPKKKKSKKIKDKSLFEKGFSFTDPNDLEDQSWNLDMAIKVAKKKDELATPTTSLQDKISKKRESKKKQKAKSREEENTEQEEEEEVTQSKATEGTKSSTEDLQDSSEDEDELEDKELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8GZZ4</accession>
    <name>A0A6P8GZZ4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="22" type="primary">LOC116286646</name>
    </gene>
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        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="4"/>
    <dbReference type="RefSeq" id="XP_031549058.1">
        <property type="nucleotide sequence ID" value="XM_031693198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8GZZ4"/>
    <dbReference type="FunCoup" id="A0A6P8GZZ4">
        <property type="interactions" value="2431"/>
    </dbReference>
    <dbReference type="GeneID" id="116286646"/>
    <dbReference type="KEGG" id="aten:116286646"/>
    <dbReference type="InParanoid" id="A0A6P8GZZ4"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isoleucine--tRNA ligase, cytoplasmic-like"/>
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    </dbReference>
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        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
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    </dbReference>
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        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
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    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057033">
        <property type="entry name" value="Ubiquitin_IARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23567">
        <property type="entry name" value="Ubiquitin_IARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="18">
        <location>
            <begin position="57"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="19">
        <location>
            <begin position="732"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Isoleucine--tRNA ligase cytoplasmic ubiquitin-like" evidence="20">
        <location>
            <begin position="1122"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_031549058.1"/>
        </source>
    </evidence>
    <sequence length="1209" mass="139386" checksum="EB39F90AD648A766" modified="2020-12-02" version="1">MWKQNSRNFSKFSFKSLNSLIRRAFASQTYSSAVDTAPEMASHAPEQHNFPKEEERILELWKKLDAFKTSLKQSEGRPRYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGYHVERRFGWDCHGLPVEYEIDQKLNIKSPEDVAKMGIAQYNKECRSIVMRYSNDWEVIVNRLGRWIDFEHDYKTLYPWFMESVWWVFKQLYEKKLVYRGFKVMPYSTACNTPLSNFESNQNYKEVVDPAVFISFPLDENPDISMIAWTTTPWTLPSNLALVVNPDMEYVKVKDNTTERLYIMMAARLEALFKTPEEYTVLERFKGETLKGKTYQPLFPYFKEMKETGAFRILTDGYVTDDSGTGVVHSAPAFGEDDYRVSIANGVIKKGGKLPCPVDANGKFTGEVTDFAGQYVKDADKHIIKLLKQHNRLVHQSTVKHNYPFCWRSDSPLIYKAVPGWFVQVESFVEKLLANNQKCYWVPEFVKEKRFHNWLQNAHDWNISRNRYWGTPIPLWVSDDYQEVVSVGSIDELAELSGVRITDLHRESVDDITIPSKTGRGVLRRVSEVFDCWFESGSMPYAQVHYPFENKEVFEQSFPADFIAEGIDQTRGWFYTLLVISTALFDKPPFKNLIVNGLVLAADGAKMSKRKKNYPNPVEIIDKYGADALRLYLINSPVVRAETLKFHEKGVKDVVKDVFLPWYNAHRFMDQNIKQFERDHNVKFTYKESNTLALNNIMDKWILSFTQSLVQFVHEEMAAYRLYTVVPRLVKFIDYLTNWYVRFNRKRLKGEQGKDDSLQAIQTLFGVVLTITKLMAPFTPFLTEHIYQSMKQYIVFDKDQSYTDSVHYLMLPKTRENLIDENIERAVAKMQSTIELGRVVRDRKTMPTKYPLPEIVIIHQDQQCLDDVMALQNYIMEELNVRKVTVSSDKEKFGVHLRAEPDSQVLGKRLKKDFKQVFQAVKELLDADLQLFQDMGELTVCGHVLSGDDLKLSYTFDKNGDRPSSYEAHSDGEILILLDVTPDQTMLDEGLAREVVNRIQKLRKRANLLPTDDVTVVYEALAAPQHRLGDIISAHQEYITSSIKQPLLAAPLPPLTEIIHERTEVKGEPLKLWILRGHKKADSSTNPSPVCRFVNVELCGVEPGNGIKSRSATVLLENPQGDFEMSIERLQNQVKAIFCLDGKKIELSTSQSCDKVLKPAELKKIHGTTLYAFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H1X5</accession>
    <name>A0A6P8H1X5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Photoreceptor-specific nuclear receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116286944</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549401.1">
        <property type="nucleotide sequence ID" value="XM_031693541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H1X5"/>
    <dbReference type="GeneID" id="116286944"/>
    <dbReference type="KEGG" id="aten:116286944"/>
    <dbReference type="InParanoid" id="A0A6P8H1X5"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01282">
        <property type="entry name" value="COUPTNFACTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="141"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031549401.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32979" checksum="783B8F5A12DC6C9B" modified="2020-12-02" version="1">MEVDAKVGEEHDREMENCSPKRTELDKKQEILCKVCGDISSGRHYGIYTCDGCSGFFMRSVRRDMVYTCKGNGTCTVDKKRRNQCQACRFKKCLDVKMNRFAVQQERQPNSARILKPHMDEYGMKSAMNNDFLASLIVAEPCRDAMLRTNQVYNIPFPQPDIPSSVYCSSPEAIFESAARLLFMSVKWARNIPSFVNLPFRDQVILLEEGWRELFIMGAVQWSLPLEVAPLLAAAGMHVENTQAEKIVGTMANIRQLQEISSRFRTLQVCEAEFACLKAIVLFKSGMKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H360</accession>
    <name>A0A6P8H360_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IQ and ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031550053.1">
        <property type="nucleotide sequence ID" value="XM_031694193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H360"/>
    <dbReference type="FunCoup" id="A0A6P8H360">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="GeneID" id="116287510"/>
    <dbReference type="KEGG" id="aten:116287510"/>
    <dbReference type="InParanoid" id="A0A6P8H360"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037695">
        <property type="entry name" value="IQUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057887">
        <property type="entry name" value="IQUB_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21074">
        <property type="entry name" value="IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21074:SF0">
        <property type="entry name" value="IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25805">
        <property type="entry name" value="IQUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="154"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550053.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="92690" checksum="E693AC4C9DA2C963" modified="2020-12-02" version="1">MSAKDEGEAVVGEKEGETVKEKSEENNENEDVKDEEGSEEKGEQNDEQNDEVNIEKQQENTNPDEVKEEDDEAQTALLPKSDEPIEQTETSAQTDGKITPDKASEVTSQSKEAASMATASVSEPNLVAPPASQIDLSSSAAEGGTKKPVESHDIKVKFVIMPEGEIINMTCNTKQTILDLRKHLSSEVGQPADIILMMHEDKLLDDTGLLSDLGAQLGQTLQIELQSSDPINNPLRVKPAAKTPTKLPPVINVKAESNGKPVEIKVHIVQEDRKKPFIGGYKHRLTGTEYHNATAQTVPKIRVPSPVECFHRDTQTYKMRNRLQQTTNTTSTQMTKDGCYVSNITDKVVIPGKYETAEDYHNKRLEKVIILQTYWRRWLAIKYVQNLKRDQHIRQEWERQEEIRKQKEKAERIRKEWDRRLNPKTKEDFDLLYAHLEKWRLEEIERIEQLYSGPERKAALIGLVEQEAYLIASIDRHKIAASNENMDKKVKSFLDKAAAPKRWRAFDGKITEMDTPYTIRAQELRDIYNTLCMKYLTQDERLDVLLTLKHTVKEHDCKLTHEIVELIDREADLLMRGVKENNLEGLRKRISTLFLQYCKTPLFNPEAARLIKVPQDPTVLRKNIYFCPSCNRYLPSTEFKLSLTSSVVGRCRKCIKLDNDARLRQDLLQYKNMLRGLRRVEEDFEDGSQIAYLIQEPDLRYLVENIWNSQSALSAHDDLFDLVLVRWNKHEEWSPWNCILLTKEEAKAHSKLDNVTEAYGRMFIGKILHKHLLARNYFSRLPGMAERMKSKISPQSAGATKGPQTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4G9</accession>
    <name>A0A6P8H4G9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4E transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116287877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031550443.1">
        <property type="nucleotide sequence ID" value="XM_031694583.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8H4G9">
        <property type="interactions" value="2974"/>
    </dbReference>
    <dbReference type="GeneID" id="116287877"/>
    <dbReference type="KEGG" id="aten:116287877"/>
    <dbReference type="InParanoid" id="A0A6P8H4G9"/>
    <dbReference type="OrthoDB" id="5989914at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018862">
        <property type="entry name" value="eIF4E-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10477">
        <property type="entry name" value="EIF4E-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="675"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="878"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="889"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031550443.1"/>
        </source>
    </evidence>
    <sequence length="1110" mass="125499" checksum="090B72239CA867A3" modified="2020-12-02" version="1">MEVEEPSEKVETANARGECEPKTINETPKQVIKNGDQEEEEKEENSKAEPKRTRVKYSYSLEDLNGLKDSPASQAWPAFIEEDCIKNGVWDPELWHHTPASAKRCASPVDDIRRQIIKEDGIVLSPQRQSFGQGCHVPQSAPERGLQQERTKNMLSRTLERDPRDGRNRLTGRVGRGSRSMDYRVNPRERPTRNGDLRQTSPWERDRNDKDYKRTKEEDGYSYKKGKKRYENIEPEPEWMTYGPTSQLETIELGGFDREEMFGKRKGKTGSFTGSDDAPKANKKEKVENKNKKNKETLDDQEEGKDEKDFDINQFFVSDAFSQFSDVLEKSNSNASRFCQFFGVDERKDGSRRSSAAEELLEYSGLSSASPSTPRTPSPNQGFMFTPIKPVDASTEPENLAEMLEKTKIDMKPLLETVMSSGKTDKERVKGQIRLEDIEKTVENDKQGEEPVKQEDSQKKDNDGQDMSAFFKLVETMATSGNLPEKPQPVIPGLPSRLLPRPPSPKANRPSRTPSPQQKFRTSPSPTEILQHMMQGHQIPSPSAIPSPPQVVPQLDRPYSPYGTPVHRSLEMLRRSPSPLSSMYNQPKSYSPLLTPDAFMMSSVMHPYPPMRGSPSRQYIDKPHFELPNEQPEKPSYRIPRPMPNPNNAGSVKTTQKSQTSALKDLAFMPTSVLQKIKKDQMTPKSKTDTDESKKDKIENGVKDSSRNVAAXKNTKQSVLPSSSRVPEQYPPGKEEIKSMFQPFSHEATLLKPTAFKPYSGMSPGSVSPLRSGIHSEPHSPVASRTSASPSQNRLPMTSXAPVTPQRPPHAEHHLXSNQQLHFHHLRNGPTSRADEFQGNERAIKSVMQEKRSLGKGIANSHEGKVPDELFHLRMQKEMSDRRQDHEQQXQLQQAIQQHQQQQQQQLRREIHNLNQMYRNRPTPPHMMGGRVSPSTLRSPGLPRTPYNTPLQNMHPQGKQGVHPAMMRSPVPSPYLRMMPPRNPSMPMPSQAAVMQMMQQHXSMMYGPGHTPMPGHHGYGPMNPPMVPPASNYPVPRHPGLMHHQGKVPSNMPQHQDPNPRXSPSDNVLAKWFSEDILRSTQGKTPSVHDKKVMSVEDLERQQAMFAAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H4V3</accession>
    <name>A0A6P8H4V3_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC116288002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Tentacle</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_031550573.1">
        <property type="nucleotide sequence ID" value="XM_031694713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H4V3"/>
    <dbReference type="GeneID" id="116288002"/>
    <dbReference type="KEGG" id="aten:116288002"/>
    <dbReference type="InParanoid" id="A0A6P8H4V3"/>
    <dbReference type="OrthoDB" id="5977689at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="144"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_031550573.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="64599" checksum="78906691E27A61CD" modified="2020-12-02" version="1">MPAEKELSYEDFKRQTKVPYVIYADFESIITKENQENGATKRLGLHEICSYGYIVVRHDGKADAPVIYRGKNAANKFLEALQDEEEKGEKPGKPSTHCIHCHKRLVEDFYMDKVLDYCSVTGAYVGAAHWRCRTHVDPEMEIPVFFHNLRGYDSHLLLQGTDGSDVKCIPNNKERYMSVTVGKLKFLDSQQFMADSLVNRVKYNTDFPISSQYGAERKGVYPYEYMDSWERFEEPLPSKERVYSTLTESGIKDEEYQHALDVWQKYGCRTRGNYHVIYLRSDVVLLADVFQSFRKMAMEYYDLDPANFYTAPGLSWSALLKKTNEQLHLLTEYDMYRFMEDGIRGGVCGPSRRFARANNPAVEYDPEKPTTYIFYLDANNLYGVDKESDKGYVLEVDLEYPEHLHDAHDEFPLAPEAIEIPSAQLSPLQQQMCPNYKPYRKLTMNLMDKRKYVVHYRNLQFYVRHGMRVKKIHRVLKFTQKPWMQPYIASNTQKRTAAKNDFENYGHHIHSVTQEKVSLSAFDGKRWMCDDGIHTMAFGHHTISSSSLTNPRVGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H6P2</accession>
    <name>A0A6P8H6P2_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116288501</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116288501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031551156.1">
        <property type="nucleotide sequence ID" value="XM_031695296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116288501"/>
    <dbReference type="KEGG" id="aten:116288501"/>
    <dbReference type="InParanoid" id="A0A6P8H6P2"/>
    <dbReference type="OrthoDB" id="5978482at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031551156.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="56741" checksum="A0988A05EA011D36" modified="2020-12-02" version="1">MVRGLHHQDSSTDFTSSSEDEGCTKTKEEQIKNVVNVGGKGNFVAVGSDANVSTTAESAGVTQNSFDVVXILKNPTTLLEAVAKCRGTEKDKIEKNILQHLLPEIENHAIKAASSCNDALELLARFCSPELKSPRLTIHSLRIMKRLLDLEFGSCESANAHIIEVERILRRSLVDGSFAENLQHIQRXRLEVYNSILALILLYLAKGHLKPPYINKTEKEEIKQTVTKNIQKTLQRNPRPKKDRWRFSMETVLNLIERLFDYNKLSXMTKLLDLCKDITLEAFLKKLQCAESSSVDYFVILKMLHGKLCTSNADAYQIIEIIIKNHDVFSKKWPHRNEDWKFSLLACQTLLHTINSTKLSKATRIKAARCLACLMEAKVCGKSEVIRNIIENHCIKTSFARDFKSRKIVIERRLKPEVLDHIPLERDVMIKQICKIHESKGLECIEIIXEDENRVIVRGLYDYQPVAITVAIINPIKNLYADQDQDLSPSEKHLQNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8A4</accession>
    <name>A0A6P8H8A4_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallophosphoesterase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116288781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031551473.1">
        <property type="nucleotide sequence ID" value="XM_031695613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8A4"/>
    <dbReference type="GeneID" id="116288781"/>
    <dbReference type="KEGG" id="aten:116288781"/>
    <dbReference type="InParanoid" id="A0A6P8H8A4"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031551473.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41612" checksum="5EC2AF4CDDF1A4EB" modified="2020-12-02" version="1">MPLFSFKKLAVSKACLVILILTVVIGDYLSFYKTSVTWKIPDREEDGSLCVLAVSDPQIQGFNGELPSILGYITRWDADRYLSHAFEAAVKFVKPDVIIFLGDLLDEGFESTNEEFSVYTQRFDRIFNVPNDIHKIYLAGDNDIGGEGPDVLSSQTVGRFTKHFGPLNDIINIKSFQFVKINTVSFLRFSVPAYKEEKETYNATLQFIHGISSRMKDDTTTIVLAHAPLPNMPSDLYHEFISKTKPKISLAGHLHKHLQVYHRIKNPVATFWEYVIPTCSYRMGTRQIGFGVLIVENNAKPKLSILKLPDRYFYLFGHLLLSCFTLFVLIIRFARRFLMSLIWKAIRLLKKVFRKHIMRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H8N4</accession>
    <name>A0A6P8H8N4_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC116286696</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031549122.1">
        <property type="nucleotide sequence ID" value="XM_031693262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H8N4"/>
    <dbReference type="GeneID" id="116286696"/>
    <dbReference type="KEGG" id="aten:116286696"/>
    <dbReference type="InParanoid" id="A0A6P8H8N4"/>
    <dbReference type="OrthoDB" id="442503at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000137">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="50"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="266"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_031549122.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="52936" checksum="EADF5D3B975501F8" modified="2020-12-02" version="1">MPSSRTMKYTKLNQFVLGFLVWMMVYSTVSSLGCRRSQNAQVKNITSQKKALSIIFKNYDKDVRPYSQDGKPVNITVNMRINSIYDVREEEMDYTIRFAFRQKWTDPRLSYDISLTHGKGHPYMQLESADQIWYPDTFFMNARSAFIHDVTKNNLGVRVFPDGSIYMSQKITVTAECQMDLRKFPMDTQICVLMFESFFHTAAEIIFKWERSEQPVAISKDMNLPHFDIVSLKTKEVNNVYKSGKFNSLEVHITFQRRLGFYIIQIYLPCVFLVFLSWMPFWMDPSETGDRLAVGITAVLTLVFLSGAMNNKMPKVSYMKAIDWYVIACFLAMVLSFVESMVVFRAVVHEDKKDAKDKEEWGEPVKRKNDVLQEDDDMRGISDDIELTDNGHLRERRSQGRIIKMQSLTRMSCGGTSKPKSLKAAKYNKIDSVSHMMFPGLFIAFNLFYWLLYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H978</accession>
    <name>A0A6P8H978_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Melanocyte-stimulating hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116286869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031549312.1">
        <property type="nucleotide sequence ID" value="XM_031693452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H978"/>
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    </dbReference>
    <dbReference type="GeneID" id="116286869"/>
    <dbReference type="KEGG" id="aten:116286869"/>
    <dbReference type="InParanoid" id="A0A6P8H978"/>
    <dbReference type="OrthoDB" id="10301161at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22750">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031549312.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36033" checksum="561C469AA675E5A9" modified="2020-12-02" version="1">MDHENGNTSVDNVCGTFQSIWADYSDRLDRNVYIINATFSVIFCFPTVAINLILFIAVWRTSTLRTPSNILICVLAITDLCVGIVEMIFAGLLFSMITNAIQTIKCVLAVLSRLLANMFAEMSFLTFTAISVDKLLMVHFHLRYNTLVTIPKILIAVTVISCLCGGIAALNFISIKLYTAFIAVITCTCFIVAFISYSKIYRTVIRHQQEIHEQTMAVATRGGNNKVLELARFKKRTFSMMCIYCIFLLFYFPYILIIIIMMTLKQENTTLAAAKIYSITFIFLNSFVNPLLICSTMREIRKAMRHMLSITKQKKNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H997</accession>
    <name>A0A6P8H997_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553014.1">
        <property type="nucleotide sequence ID" value="XM_031697154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8H997"/>
    <dbReference type="GeneID" id="116290158"/>
    <dbReference type="KEGG" id="aten:116290158"/>
    <dbReference type="InParanoid" id="A0A6P8H997"/>
    <dbReference type="OrthoDB" id="5954510at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028415054" evidence="1">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553014.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22649" checksum="DA3E0B2EDC93BD61" modified="2020-12-02" version="1">MYPWCWFVFVILLQTAVENKGSPPTWPYGKYTLLKPRTGCPAGWDDMGYLYQDTMNKNPSNNRSQTLHIDGEVARSHVKRYFCSKTERMGKNITQVWPLGQFCVYSRVSETLYGMTSGSIAMYDRGNNYDKDQSKFTKFFEFLKKKIFGSYEVTRLYFSCQTSGDKKIPISLPITKPFYLLPYGSRDCQQVKWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8H9M7</accession>
    <name>A0A6P8H9M7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Substance-P receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16" type="primary">LOC116289437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552236.1">
        <property type="nucleotide sequence ID" value="XM_031696376.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552237.1">
        <property type="nucleotide sequence ID" value="XM_031696377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552238.1">
        <property type="nucleotide sequence ID" value="XM_031696378.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552239.1">
        <property type="nucleotide sequence ID" value="XM_031696379.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031552240.1">
        <property type="nucleotide sequence ID" value="XM_031696380.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289437"/>
    <dbReference type="KEGG" id="aten:116289437"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031552236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031552237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031552238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_031552239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_031552240.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42821" checksum="4C2C667331EC4BF3" modified="2020-12-02" version="1">METMESKIVKTIASALVTFFAILGNLLVIAAVLLIPRMKTVTNYLIVNMAVADLLYILVIMPPFFVEIFELYTWAMENYGQGVYFCKIXNFGQYFLATVSVLTLAAIAADRFFAIVLPLRKVFTKQVFYYIVPVIWXIASAVAAPVLYAFKIKETEDGYLSCEQDWAPAFDDLRASLIYSGILFAVVYCIPFLAITVMYAIICRRLWKRKILNTRHKRQYQKAIESRKKVVKMLITVVIAFVICWLPVQVITFIWEANPHIKFPYSLFFVCMFLMRAHACTSPFVYAIFSENYRRGFKVALTSCCYGRKFSLXXQPSLLRSTNMTMSSRRSYQLKVISRELSPNEEDDNCEKKTITNCLLKNGNQATTIMDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HBJ0</accession>
    <name>A0A6P8HBJ0_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116289679</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552493.1">
        <property type="nucleotide sequence ID" value="XM_031696633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HBJ0"/>
    <dbReference type="FunCoup" id="A0A6P8HBJ0">
        <property type="interactions" value="1800"/>
    </dbReference>
    <dbReference type="GeneID" id="116289679"/>
    <dbReference type="KEGG" id="aten:116289679"/>
    <dbReference type="InParanoid" id="A0A6P8HBJ0"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17044">
        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000016">
        <property type="entry name" value="Tubulin-folding cofactor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="11">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031552493.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59955" checksum="E6BBB4DAB3B18109" modified="2020-12-02" version="1">MADGVTFVGKRVICDDFIGTVKYFGVVPPTQGEWLGVEWDDEKRGKHDGTLDGVSYFVCSHPKSGSFVRLKKVNFGVSVIDALKQRYGVKHDTVQDMYVVDANNKKTAVEMVGVNDVHKVQSCFEKLVEVGLREQLVNGPDKDVSLSSVAPNIVQLDISRNLIASWDDLAKVIKDLNKLKTLNVSENQLTLPTDHSLLKSSFCMIKELYLNRMNLSWTEVLMIMTMFPDLEDLHVCYNAIDSLRLNNDEENSNQCLLNQKIVTLNLEGNLISNWSDITLLGNLTRLKTLILNDNKLIDVIFDDDTGSNKTNLFPSLTSLSFSRNSIKDITSVNALNKLVDLVELRFKDNPVFKGETGFSIRQELIARISSVKTVNGSPVTEKERLAAERAYIKKYAKDWFDAGGKVDNYDANKLTTEFVEKHPRYAELARVHGIPDSEVHQKTAATLKESLIALTFKCPDDSSKKVLTKKLPGTMTIGKLKGLLYRLYKVDSADQKLSYLDTKNDREIQLDDDLRSLSFYSVVQGDTLYVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC10</accession>
    <name>A0A6P8HC10_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116287662</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116287662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031550212.1">
        <property type="nucleotide sequence ID" value="XM_031694352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116287662"/>
    <dbReference type="KEGG" id="aten:116287662"/>
    <dbReference type="InParanoid" id="A0A6P8HC10"/>
    <dbReference type="OrthoDB" id="100767at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031550212.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43097" checksum="719E60B5C1CF025D" modified="2020-12-02" version="1">MQQHGSDATKACLAEALFKIERRDIAENLIGNEHFTSKTSHEQIFLFKEEGSFKIPGENGQDVRFLTCRNIQNGKLYLVRELTGTKYEESCKALKQQDSIADSILSSLDVHGIVEEERQKKENQKFKEAQDKITELLKNCXADSILSSLDVHGIVDEERRKNENQKFKEAQDKITELLKNCQELTNRIQNQERNEKEVLQQLHEEKTSLAEMQRLGTGLLQLTGIVSHLKDPFPLQAQMYSFSLGLRAILKDLQERVKVLKEMAPSGETXGIEKVLNQCRNLSKEIQMKENRFLKLSKADNLEGQQRXRDECSPSAPQPRTSGYPVDVPEVRRASTQPVSEXELRALREQVAPPPDPLEHEEEASIPYVNSENEDSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HC98</accession>
    <name>A0A6P8HC98_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116290381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116290381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031553261.1">
        <property type="nucleotide sequence ID" value="XM_031697401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116290381"/>
    <dbReference type="KEGG" id="aten:116290381"/>
    <dbReference type="InParanoid" id="A0A6P8HC98"/>
    <dbReference type="OrthoDB" id="5984844at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031553261.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="55434" checksum="597017F738A81522" modified="2020-12-02" version="1">MAANEAENSSQDISSLPELTFAFVENYAKDKSGCKSTSKAYKFFAEPGYLHDIKVAYDLDSAVINARCYRSMKKSEPPYILQAKIKLTDCSASGRCSCVAGIGGYCHHVVGLLYYIAHCKQLGLRSVPDSLTCTSMPKRWSIPRGKKIEQKEIQDILVKKPKIGANYSKFIKSTLYSPSEVYRTMTKEDFDNFETKPLIASILPSAENLASISFVQCKFGKVPKGSIISYQQKLSQDYVINDFSCTNFPKLPLDSAESRFENTFSSCQTQQQQASLDALRVSTEASLDIQEKTMTQSANNLWHVLRSKRITASKFGIVAKXVRDFENLVKQLNPSRHVVTAPMRRGIEMEPTAAMTYANNLKGGSVNLFPSGLIIHPKCPWLGCSPDRKVYDLEAVQNGSNPFGLLEIKVVKEGETDFGNVRYLTNDPITNEYSLKKTDIYYYQVQCQLALTGLEWCDFFSYISDNLLVCKRILFDKDFFQEAKDKVDSFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HF70</accession>
    <name>A0A6P8HF70_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291964</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IER family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555059.1">
        <property type="nucleotide sequence ID" value="XM_031699199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HF70"/>
    <dbReference type="GeneID" id="116291964"/>
    <dbReference type="KEGG" id="aten:116291964"/>
    <dbReference type="InParanoid" id="A0A6P8HF70"/>
    <dbReference type="OrthoDB" id="5973588at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008653">
        <property type="entry name" value="IER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15895">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05760">
        <property type="entry name" value="IER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031555059.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26451" checksum="65532938FBF838E7" modified="2020-12-02" version="1">MEREMERIIQVSLTKITDCRRRRGGPMLRRSLLVSNVLNNALTSSETSYGHYRTPKDGDVDCDGLEQESVCLERPVLLRDDTGGSGNAHELRNSTNNMDSKVLCERTADNQVTNMNISKEVNPKVLHSSALANCSSGNKESKAVKRPRSHYANDTCENHAVTRKRCRTEQNTTERNTLDAENIEPMDVSGLVNVFSNSLSGLSGFSSKSSNDSFIFSCITPPVNGVYSQPSWQQTVAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HFU9</accession>
    <name>A0A6P8HFU9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031555289.1">
        <property type="nucleotide sequence ID" value="XM_031699429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HFU9"/>
    <dbReference type="GeneID" id="116292165"/>
    <dbReference type="KEGG" id="aten:116292165"/>
    <dbReference type="InParanoid" id="A0A6P8HFU9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031555289.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19063" checksum="FEB0C738E0076FAB" modified="2020-12-02" version="1">MGGKYQRLASEAGSKTLKAGLLSYLFFTWLNGILKLGYQRPLTDDDLLELSDENKAQDLVAKLHGLWMEEINCAKKRGRKPRLWKAMFKLFLRDVLLFTALKLIDEAMGITLVVSVWFYLKFLEEGSHMDQTYAVGIVASIGIPSLIKVFFYHHSDYLAVLMGVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHE3</accession>
    <name>A0A6P8HHE3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116289246</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116289246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031551995.1">
        <property type="nucleotide sequence ID" value="XM_031696135.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116289246"/>
    <dbReference type="KEGG" id="aten:116289246"/>
    <dbReference type="InParanoid" id="A0A6P8HHE3"/>
    <dbReference type="OrthoDB" id="5966174at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF9">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="1842"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031551995.1"/>
        </source>
    </evidence>
    <sequence length="2335" mass="278828" checksum="4F3D5B8DD39D8330" modified="2020-12-02" version="1">MAQPSKYQAQKEVRRWNVKAKYGNWTAQNPRRPLGPTLRTSSVTRPPPSIDTTNPASRKSSLDSLVDSDFSDTSFYDFPSWFAKNPKKTSLGPSSTVGVVVPPYHSESFHAHAFPEHRFQGESTSRRSDGRRPISGLSKYPQPDPLTSEQKPLQQYYRPYYNQFNPYSTMNNTGYSQPLENGSRQNGTGQDSQTQYHNGRHGNYSAKDGQQNTEMVQEYVPLVAVSPDLIDRTRSPPTASPSCSPESDDTLARSSSGFASDIESPRSLKSCLVETPRGLVQSAIGVDYRGNYSSRDNSFKREHLDAKTVSFSKNGVSEKHLNGGHGLGQAPRESEFRRRLHSTRLSSNSTSSAIKPYHVQSNVVDSNGSLYSYDKMSSSLPYTTASSQLSSSIYHPQSPPTRDASKVNTSKSLYLHQNNSSVPAMSLFEETGMVFGKHLVQTPSRNLQSNLNGGASFEKDKQTNMYKLQETRYNNELVLNNGMDATRRNKQQGPPSKQSFHSLNNGKRDPTLPNHVSLVNSFSVDTSRRISSAVWAMKVLEAEQTTTPALYQQLLLKARLFRRWHQRARLRRLERMESDNKMNKAVEFWRGVTLHKHLSAWKELRHIQETKADDTYRRHMLETGLRGLKFATHVNSQARRDVETKINGRLMAKYWLKWQGHMMRRRGERMRSLFNRWRVFQLEGNREKILDGMANKHFMSRKYVKWKMRYQVEQNNSVARLNFKITLLTKCWHSWRIYTAQRIVKTRTNEVARIHYENNLQTRVFLQWLEGSRKSSIASNLSKRRIVVKAFYSWRNWTEYAKVIHQRFQSMCKEYYNKSLVKQTFIQWKRKLMVKQAENFHGKLLQKRVYRLWFLRYRRKVIHRHLCKAMARKGKKRRFFRKLLEVTRSQRERRNAFVGILQKLLLTKMMKTWREHTIMKKSLRIRYIRLIQIKESRLTVKAMNQWLFAMKVANFKKQAKINWSKRCTRKACEEWKLLLKRKHLEETLIESRPTRDTWILRVAWNTWMKKKKIANQELERVITVKTILARNFKRRILQAWRVTNQQQQIIAPMVQRRERKHIARAFDAWRLYLHRQKYIVNQQSRGDEKLVDRHFLYWRDRVMLRIKERNAVTSLQNSKLTRAFKAWQAHVREIRHQKLKERAERLQLLSVYFNKWTISAEARAEEKEQRQANQARKVLLVRWGFRYWKESSERQRLRLNLIEEEVTSSRNRLALKRFFDTWKRWFTVANIARDHIAYRRDNLLRTAFTAWGNFIKQEINEQVNRFSTGLSLDCSMGSNMGSLLRSTMDSSASDYLSSSGYGTSFRRGSGSVFPLRSPGISQRDDDIASLPGRFDQLHPDSPRRVASPITVLRESNHVVQVTSPLVVQTPTSSPSPSPPDLHLSLPLSVTSYESVFSPVKDKEFLLAKPDSFEMHRSISLADDDEFEHMSMTSGMSSASVRDKEMVIIDTILHWRSLPLSLTFRSWLKYTREQKLLRDLLFYSKEKKTREIIAGTMKRWRRELYIKVAARQYLRDGTRLRCLRAWHLYVKTRRMKERRNADAKNLNRSFLIKRFFDDWKNKYTAKKRLQTIVVQWQKKAIITDKHKAIGEKVQMKHDQQALRRRFYYWVKMTRKSQEARRFYLERLLPRFFISWHLYSSARSENRKKGAYFNDRRILAMAFREWQEQFISERKAKDFLEAKEIECSLDILRTWHEWANGVRTRRVQWRNFHRSLEIKTMKGIFSAWREQVLQREHAEQYYHHTVMRKVLLSWRRTVQASIENRLKASALKESCSNNLLKRSFTFWRRLYLHRQLALSHAQQKDRDLLRERFLDWRDYTLESRAEKHYLKAMVKKVYYRWYDEYLSRKKARRLLRSWKSITEDSKALNSKAMELCQLSEKKVLHQTFTFWMQEAHKIQKAKLHYATNTTRSSLKAWFRYAHTKTRCRKTLADIEASRNQDLISRSFFTWRDRFTRNASNQEILDEHLRNKQFQSLESCMLKWHKYTLNCRALKHHDGRLQYMSLMKWRLRLSQKKGLEKIMERVFYRRIRQAAVHWRQWTVKTKREQARADEFQFEMGNRHVRVCFAYWVNSTEQSTRAKDHHNNTVLKRSLMVWQSVITAKIKQQKIMEKFQKEVMAKKVGRMFKEWRAALKQAQKHNQLVSIQMSKHNKLVLQGCMRQWKKYIQKCRADKHFNIVLTARFFLNWKSRFNERMERKQKEKELGDIALDHYHHRLRKLCFRSWYYDVLVGKHLEMKQQQLVHKHFHLWKKKQRLKTIASELGDRQLYSKYWGKWRNQLVRKRVSELMMKHEEKKLLSEVFGAWYKLTMIRRRLLMEWNIAVVEKWFRKWMQKYNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHF7</accession>
    <name>A0A6P8HHF7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide FF receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC116289255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031552010.1">
        <property type="nucleotide sequence ID" value="XM_031696150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HHF7"/>
    <dbReference type="FunCoup" id="A0A6P8HHF7">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="GeneID" id="116289255"/>
    <dbReference type="KEGG" id="aten:116289255"/>
    <dbReference type="InParanoid" id="A0A6P8HHF7"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_031552010.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44609" checksum="40BBE1F78C7039AE" modified="2020-12-02" version="1">MPHMEEEMANDSSSSFDSNSSIFSNSNQNYSNSNDLEWRDLEWRLGIDITIFVVAVIGNFAVLVVIYTTRERRKTPFEILIANLSVADVLSVLLYFKYLIYFNIPRPKWYCKLVVPFFSSTQMVSVLTMTTIAIFPCRSIVHPFKTKPSTKLTYSTVAGLWLVANICLIPDYLVREQYQGRCKEIWPSELLNKVYTVSLFVVQYMIPLTIIAISYTKIILYLKRNKVPQCGLTSDRIKQLKMTRKRDMEVIKISLIIVLLYTISTLPIHMAWILLIVFESNHMSSLIFKFSPQLLLLHSCCNPFVYGTISREYRSRFVQVLWSILCCVCKIRRTQTGVLQTEQGQMNNACEDLEMIEIKGYVKRDKAATEPATDRPTEERTNKATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HHK9</accession>
    <name>A0A6P8HHK9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC116289305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031552055.1">
        <property type="nucleotide sequence ID" value="XM_031696195.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HHK9">
        <property type="interactions" value="3063"/>
    </dbReference>
    <dbReference type="GeneID" id="116289305"/>
    <dbReference type="KEGG" id="aten:116289305"/>
    <dbReference type="InParanoid" id="A0A6P8HHK9"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="718"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_031552055.1"/>
        </source>
    </evidence>
    <sequence length="836" mass="92488" checksum="3681308533CBBB84" modified="2020-12-02" version="1">MPAPLKLRDLIRTIRAARTAADERAVISKECASIRDAFREEDNDFRCRSVAKLLYIHMLGYPAHFGQLECLKLIASPKFTDKRIGYLGAMLLLDERQDVHLLVTNSMKNDMNHTNQFVVGLALCALGTICSQEMSRDLAGEIEKLIKSTNSYIRKKATLCATRIIRKVPELIEIFVPSTRSLLHERNHGVLLTGITLVTSMCNLNTETLSHFKRHVSTLVKVLKNLIMSGYSPEHDVSGISDPFLQVQIIRLLRILGKDDEEASEHXNDVLAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALNTLLKTVTADYNAVQRHRSTILDCLKDPDISIRRRAIELSFALVNTSNIRGMMKELLAFLNKTDVEFKSYVASNILLVADKHSPNKRWHIDTMMKVLTTSGNYVMDETVPSLIHMVCASSELQAYSVQRLFKAMQHDISQQSLVQIGSWCCGEFGEKLLIDIEEDEPQGITERDVIDVLESILYSSHSTAVTRDYALNAVMKLSTRFTQEIDRIQAVVKNFGCNMDVELQQRGVEYGALFDKYNNMRPGLLERMPLAKISKMNGDLTNGEVEPDTPPELKQVEIEQKPPQQKQDSDALLDLLGGGETINTAPPEPLAVPKPASSGGDLLDLLGGLDMGPTTAPVGLNPMAPLASMNQAPNLLSGGGLLSPGNTSQPAMQVNNEMPVQSSGIPPLTAYEKGGLKIDFSFERDPNNPCLSTISVNAVNSLSVPMTDFIFQAAVPKTFQLQMQSPSGNMIPPNNTGSVTQKIQVNNPQQQPLRMRIKISYKLNGAPISEQGEINKFPPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HI67</accession>
    <name>A0A6P8HI67_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Receptor-type tyrosine-protein phosphatase S-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116291588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031554623.1">
        <property type="nucleotide sequence ID" value="XM_031698763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291588"/>
    <dbReference type="KEGG" id="aten:116291588"/>
    <dbReference type="InParanoid" id="A0A6P8HI67"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd21699">
        <property type="entry name" value="JMTM_APP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="209"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="311"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="648"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031554623.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="84982" checksum="18A688189624553B" modified="2020-12-02" version="1">TRCTLQMTPATPISSSSIQVHWTQQSSEKCRNAVLDGYKVVYGLWNAERNKYKVLDVTNPSSTSAVVTGLGTFTWYRFLVQAYRGKLDGPLSNWKAARTLEDAPSCFPQLTSPTANSSTSIRVSWTPLRPNKKCINGQLRGYKVAYRLSRTGSTLQYITVNNSSATSVVVRRLDKYTWYRFQVLAYTIKDGQLSNAVEERTKEDEPDASPLALHVFTLNATTYEATWSEVPGGMRNGLVIKYEVRWMTTGRKGKQTTARQSNTRGKIYDFSYTIHGLSLCAQYSISVRAYTGIGPGPYSAPVNITTQRPGSPLDFKASLQKKTTVRLFWRKPANVKNPIQSYKVQYEGFKFYWNDFKHTKSHTQRTTNLTIPNLIPLTNYTFKVFATTKCGDSPASITRIIIAIXRPVAPAAQVEHHNDTGTVLNITIWKAEPRNGPISAYQVIVLRLQDEITTTSKLPSNYTENIFNHSTAADKNLHYYITAELPAEAFESKTKVVTIGDGTVFNNMYKNVPLEKGQRYIMYERALTYYNETILYGKEALISFISVERASVKIAKSKSSLSAGGVIGILVAVALVLVIIIVGARMWRRRQNKNENIPVPLHVLNMEHQREENVMTGNVYGDDNSQAIKVDEFSEFITRNRCHDFAVLKQEYKMAPNHQFSWTIAKKPVNTNKNRYGNIVPYDNSRVAIKPVKSEPGSDYINASYMHGYAKKPKAYVATQGPLTQTFNDFWKMIWEQKASSIVMLTNLLELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HK27</accession>
    <name>A0A6P8HK27_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
            <ecNumber evidence="5">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC116292951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031556161.1">
        <property type="nucleotide sequence ID" value="XM_031700301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HK27"/>
    <dbReference type="FunCoup" id="A0A6P8HK27">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="GeneID" id="116292951"/>
    <dbReference type="KEGG" id="aten:116292951"/>
    <dbReference type="InParanoid" id="A0A6P8HK27"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031556161.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="55433" checksum="4FC3D0C6C6C37107" modified="2020-12-02" version="1">MADEAGNLSYRDLQHKFVSNLNGTSLFEISVVVSCAPMAVLLRTCVGGIVMGSMASHSWLSSSIILFLDYMTLVIPIILSFTVLADYASKMLVAMAVFIGSCMVLKSAVNYFEGNLSTKTLLHSRTNGRQPFICNFRAYVLIATAISILAVDFPIYPRRFAKAETYGTGIMDVGVGAFVVSNAIVAPEARNVSKKGTSFLKSFIKSLISSSPLLVLGLLRCLAVKSTDYQEHISEYGVHWNFFITLFIVRVLSTIIVYLITSPNAYGPTGLGLAIFYQYCLSKLGLEDFILHGSGGDGSRHGLVNANREGMVSCIGYLALYLMGLQLGRFLFIKRDTFSSWLKAFILLVLLDILFWVLTITCSNNVQPVSRRMANLTFVLWQMAYNIQLLSSFLLADLIVAVTMVTKSDNPKAAGCEVCYASTESLKRKPIRQTYCACLITAINRNQLAYFLLANLLTGAVNLSVKTLFCSQGQSLGIVCGYMFILNLVFSVLHIWNITLRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNQ6</accession>
    <name>A0A6P8HNQ6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein atonal homolog 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556663.1">
        <property type="nucleotide sequence ID" value="XM_031700803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNQ6"/>
    <dbReference type="GeneID" id="116293381"/>
    <dbReference type="KEGG" id="aten:116293381"/>
    <dbReference type="InParanoid" id="A0A6P8HNQ6"/>
    <dbReference type="OrthoDB" id="6022561at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11390">
        <property type="entry name" value="bHLH_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF163">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="61"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556663.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17291" checksum="FF9480302781C65A" modified="2020-12-02" version="1">MNNQVLCPRSIEEDNFAKMYAEQATTFPWSLFQNTPSQKDEENHKTSKRSRTSVPQTVRRHRQLRRNARERERQGRLNSAFDVLRGVIPDYLSGKGPERKLTQIETLRLATHYIMALSEMLEEENQKPAAEYCECGLAFSSTRTIGQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HNS1</accession>
    <name>A0A6P8HNS1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC116294521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558004.1">
        <property type="nucleotide sequence ID" value="XM_031702144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HNS1"/>
    <dbReference type="FunCoup" id="A0A6P8HNS1">
        <property type="interactions" value="737"/>
    </dbReference>
    <dbReference type="GeneID" id="116294521"/>
    <dbReference type="KEGG" id="aten:116294521"/>
    <dbReference type="InParanoid" id="A0A6P8HNS1"/>
    <dbReference type="OrthoDB" id="5970108at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_031558004.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24965" checksum="5F0FBD1072DE47FC" modified="2020-12-02" version="1">MVLHSRSMKSRSFHLESENIRGELLILKCRSSNSLSCEIEVYPRSTRKSVFLVPLSFLVVVGATFVTWWISDVQSTSSTWLFASCLLGLIILWIKYNYFDVIKESVTVVKNIGIQIKTTYKSGKQALKFVDHKSVADIIINEAITMHKVIFYVAILTRNSENTKKDLKLVPLFTSFYPRLEGLKPIYHSIRDIIFNDHDQEEWPGHSLIGLKHSGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HPG6</accession>
    <name>A0A6P8HPG6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC116291497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116291497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031554527.1">
        <property type="nucleotide sequence ID" value="XM_031698667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116291497"/>
    <dbReference type="KEGG" id="aten:116291497"/>
    <dbReference type="InParanoid" id="A0A6P8HPG6"/>
    <dbReference type="OrthoDB" id="5968624at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031554527.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16968" checksum="FA5C43A1653BA9AB" modified="2020-12-02" version="1">MSTRGMREKYGIETLYEGKQLIVRKKPVRFRYKVGDMVRIAKTRMTFEKSYLPGWSEEIFKIDSRQASHPPTYRIKDLNGQEIQGRFYEKELQKXNKRDEVYRVEKIIRRRQRKGVKEVLVKWLGWPQDFNSWIPESDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQ05</accession>
    <name>A0A6P8HQ05_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">E3 ubiquitin-protein ligase RNF19B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC116291660</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031554716.1">
        <property type="nucleotide sequence ID" value="XM_031698856.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_031554717.1">
        <property type="nucleotide sequence ID" value="XM_031698857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQ05"/>
    <dbReference type="GeneID" id="116291660"/>
    <dbReference type="KEGG" id="aten:116291660"/>
    <dbReference type="OrthoDB" id="5952631at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_031554716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031554717.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34852" checksum="8C6B6EEEC86F978C" modified="2020-12-02" version="1">MADEKERHCLSCQEKDFLIMACNDDCHHLCLQCLSLWLRSKTNEPDSFNYQCPLYDECHSSFDPDTVNDILVQLPDNSQGVTSKDVQKLSVNSAVRSDKKVSCPNCAFFWTEDEDFVELFANCSACKTAFCLTCEHILGPYSHLDHVCPLDNNSKNERKAVAEILSEASTFKCKNPNCEYSRAGTCMAKQEGDCNVIRCSSCKIYYCYICSKSLGFGKIRAHESFPHENSLIPGAPNCWIFDEIAFNHTTEEASNLRKLHQLSKYFSSLPISKKAKQVVLAQCRDLVGDLSEKIVLELNESTVNKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HQC9</accession>
    <name>A0A6P8HQC9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NPC intracellular cholesterol transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116295019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558579.1">
        <property type="nucleotide sequence ID" value="XM_031702719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HQC9"/>
    <dbReference type="FunCoup" id="A0A6P8HQC9">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="GeneID" id="116295019"/>
    <dbReference type="KEGG" id="aten:116295019"/>
    <dbReference type="InParanoid" id="A0A6P8HQC9"/>
    <dbReference type="OrthoDB" id="5965801at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028191011" evidence="6">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031558579.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16595" checksum="709D664F55E9EEA9" modified="2020-12-02" version="1">MAKVFLIACILYVLYLANAEVVKFDDCTGGEGKGEITQLEVIPCPKQPCELKKGTKVQVKVTFVPHEDLTSAVSVVHGEIGGFPVPFPLPNPDCCKDSGLKCPLKAGQKYVYSSALEIKSAYPAIKVAVKWEMQDPKKQDVFCFEIATKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HSA8</accession>
    <name>A0A6P8HSA8_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger CCCH domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC116294570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031558058.1">
        <property type="nucleotide sequence ID" value="XM_031702198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HSA8"/>
    <dbReference type="GeneID" id="116294570"/>
    <dbReference type="KEGG" id="aten:116294570"/>
    <dbReference type="InParanoid" id="A0A6P8HSA8"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000008">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_031558058.1"/>
        </source>
    </evidence>
    <sequence length="791" mass="88323" checksum="BC0133486AAB845A" modified="2020-12-02" version="1">MATNSDAEKLRKQIEVLSSLISTHREIKKNDSSTNKQQSSVKYNWKKESSENKKESESSSRNELSDEGQYKNNSFPLDRRKDGNSVEFRAKTSASNPLPRTGTTKTYKNNNSYQKSEQIIPLLRPSVSRDTHISKSFLVSVDKDNKCSKILDRNDDKTREGIVSEMWLHETSKKGVNSLSASRSLLSARLSSLSSSIAAAKSKLNLESSAVSNTGSEKLTKFPSTTSYSSSNVLMKSSSSSLKTQDKINWSSSSSSFSWSKLQTSVPRTSSLFNMNKPSTSSSSSHILMNSLPSSLNNKGKINQSSSSSYSWSKLGTSVLRTSSLSNMNKPSTSSLKWTKPIRTNKNRSTLGNKPLHATRVSVKPSHGNTLVWRSQQSLKLDRRKRRSITSESKGFMRRRQKALKDVPRKAVHVSRYSLVNCKRKNPIKAEKSNKVVIIEGVQYKSSANKLQKASQEKTGRNPKKAKRRPSMTLNIRGEKFLMSESGKTLTRINPGKTPIRKGPERDTPREAASISEGTKGKHAKSRSSLSKVSIGGVTFVQTAPGVLVRSNDAVNKKIASRVVRRSVQHAILYKYKKNVKTKSKSEQYCMFYNRFGKCNKGVNCPYIHDPTKIAVCTKFLQGKCKKTDGTCSFSHKIDKDKMPVCQFFLKGTCTNDDCPYSHVNVNSKAAVCQDFIRGYCVNGQQCKMKHILDCEEFSRTGKCSKGKKCNLIHRERKAKKRSRQSSTSKEPKPKQAALEQLTEEDGFLPLVQIDVSTEKDSSHPDDVTHKQPAESIAIKPRFLVNKDKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTG7</accession>
    <name>A0A6P8HTG7_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein arginine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116292768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_031555980.1">
        <property type="nucleotide sequence ID" value="XM_031700120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HTG7"/>
    <dbReference type="FunCoup" id="A0A6P8HTG7">
        <property type="interactions" value="3418"/>
    </dbReference>
    <dbReference type="GeneID" id="116292768"/>
    <dbReference type="KEGG" id="aten:116292768"/>
    <dbReference type="InParanoid" id="A0A6P8HTG7"/>
    <dbReference type="OrthoDB" id="412876at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000070">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000071">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014644">
        <property type="entry name" value="MeTrfase_PRMT7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF4">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036946">
        <property type="entry name" value="Arg_N-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="279"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="537"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031555980.1"/>
        </source>
    </evidence>
    <sequence length="714" mass="80486" checksum="2C974624D8580ADB" modified="2020-12-02" version="1">MFCQRFSPITGKMEWVVEDENYDLRDEIARSAYADMLHDDERNKKYYAATKEAVEKMKSVGEKIHVLDIGTGSGLLAMMAATSGADTATACEAFPPIAKVAAEIIEKNGFKDRLKVVNKRSTDVILGPENCDMDSRANLLVTELWDTELIGEGALPTLIDACQRLLEPGFVCIPAAGTIYAQVFTCTALWEMHQLEPDKLPCGTQIKLPNSMTTCLGTTSGFDLHVDEIHDHEIGFLSEPIPVLRFDFCDNNLNSNCPNVFSIPNSITSFKEGENKEAQYHAETIATETGVAHGVVVWWLLDMDVDGKITLETAPRWAHPDGDKCQWRDHWMQAVYYLKKPLPIKQEQELKVYCCHDEYSLWFDVQHGESLLTAVERPICTCGAHITWSRHRYCMLNDIERNSVFESALSKLVNSGCSSAFCVSDKSLLPVTAASAGFKEVLVLESSISFTKLLQKILHINDLNDRVHLLDKTLDNVCKDDMPNGKIDAVIGEPYFNTSLLPWHNLYFWYALTTIRQLVNKDVKVMPQGGILRGIAVEFKDLWKYHSPVNRVEGFDLSLFDQLIEKSKLKNEEIDGDCETCIALEPHHVWEYPSSPLTDVIDLMEFEFTKPLPEKTLKKSGVVPITGLGTLHCVVLWMDFHVMDDVFITNGLTKKCKSTGTDTLDWVRHTKQAVYFMRCPTYLDEKAASEATLAYTVTFEPTQGDVKLSFDLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTH6</accession>
    <name>A0A6P8HTH6_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116294975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031558538.1">
        <property type="nucleotide sequence ID" value="XM_031702678.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116294975"/>
    <dbReference type="KEGG" id="aten:116294975"/>
    <dbReference type="InParanoid" id="A0A6P8HTH6"/>
    <dbReference type="OrthoDB" id="5986588at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="2">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031558538.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="68747" checksum="470BAD83838D91D6" modified="2020-12-02" version="1">MNAYNLIMVAYTNMQKYDDTILYAHKLLDCAMKNNNQEGMMEAYLELGVAHYALNHYQDATDFGKKCIGIAREIENRRVEVGAYLLMGQTYIALSDYDNAIIYCKKCIELAVTIGEKRAEAQAYSLLGEIYISLEKYDDAIQNFKQCIDIVKRFRFEKKPAVNAFLYLGKIYETLDQYNDAVHYYKKCIDMAQETGEKKIEAQACLGLSCLYRTLVDKESMDNAIQYXNKGLKIXQEIGDKNTEMDGYHCLAHAYIDSMQLNEASLSMDAGMAIATELGDKEAEENFNVIRSSLYCTVGLQNKVDAPLLKELIEVPTCSEDALLQDLDQAVKTGDKKKESRAFMRLYKFYRSRKEYVKTINCLQLFKEMNVDCSVNLFCITEMGNLYHLMGQNDMALHNFEQGLPTAESCSVTGQLSLFYHGFGQLLCSLNRELILAEHYLREAIRCFEATFTTLGSREEFKISIFDEYIDSYKLLAILLITGKQIEEAVLVLDRCRARALKDLMMSNFKMEQEESNDEHLEYSDVLSLVSRNDFSIAFYTICFDALLKFFIGGETNSHYSRCPNHSLQIDVDRSFKEMGVGEVVDCENRSLDKEEDIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HTY7</accession>
    <name>A0A6P8HTY7_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Adhesion G protein-coupled receptor L3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC116296033</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031559854.1">
        <property type="nucleotide sequence ID" value="XM_031703994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296033"/>
    <dbReference type="KEGG" id="aten:116296033"/>
    <dbReference type="InParanoid" id="A0A6P8HTY7"/>
    <dbReference type="OrthoDB" id="5961629at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
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        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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    <feature type="chain" id="PRO_5027760255" evidence="9">
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            <begin position="23"/>
            <end position="1548"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="977"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="1046"/>
            <end position="1072"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <sequence length="1548" mass="173492" checksum="6453798C9D9C7EA6" modified="2020-12-02" version="1">MEFPRIIICGCLLLLLVHKTNAECKSALGMSRQNNKGKYIADSQITASSELLQFFGPSQGRLDLSPSVSGVGGGWCAGDKDPDPYIQVDLLRIHTITKLATQGIETYTSWVTQFSVQYSIDGVRWYDYKESGKVRVFTGNRNTALHKIATFTTPITARIIRIKPLRANNDYKCLRMELYGCEPIEDCDTPVGLEDGRIENNQISASSHWNEHVASNARLNNRMHTDNNTGKVVWGGWCTDKKNIHQYLEVDLGHVRAVSGIATQGYQLNNFVKQYKMNYSIDGREWKSYKANGASMIFAANWDNETVIKNPLIRIFARFIRLNPVSWDVFGYVCMRVEIYECLPTKGSVPQVSPPGASYKVNRTSPLNVTCLLSGQEGFDYTWMRNGIPVVNSNTQTIYRQIFSNGTTLSTLRLQYIKYQDSGSVISCTAWYPGLAINTSRNVHVFVNAPRPVIKVSEHKARAISMGIIDPVPQDTAKYLVRYRIKDLENAPWSTTQFTRPRIKSSSIAYITLDKLIPFTTYVTEISSAYKDGDSGPYSIPVTFTTQEDVPSGPPRDVLVEPVSDGHIIVSWSVPGFDQQNGRIMKYEVTYRSKTKKPKSLFTQQLQKDIIGLEKDQRYEITVRAYTRVGPGPYSKYVIYSTETGLKPKTKTTMALEKLSKVTVTEYNAAKVTATVQNLTSKQTELQEQDIHMTANILNKVISTNSSSEKVGDNLLKTLSNVMDVDSEVLYKTQAKYNTSATLVKVLETYIEKGGRFTVDTDNIVVRRQQIKNSFKVLRTSVTTQNNKLYLNSTTEVTSGSEPKGSDASIIIPSSVFPKDETNNETVYFVYYKSSKLFAPNYQRIEVCRDGFTSSKLGKTESRGSTYTVERVASRGLVTESSPVISASLKGREVANLTEPVIIMFKLPPEMIEANQTKCVWWDFTAKNGRGGWSTEGCELQGVLNDTVMCECNHMTNFAALVDVYGPSSKPCGVHEIALSMIAYIGCGLSILGLCLTILTYGFCAKLRKDIAAKILLHLCIALLSVLIVFVAGIEKGVTSKLSCQIVAVLIHYFLLVAFMWFFFEAYFMYYAFVKVWNDHGDYILWKCASIAWGLPAVAVIVTIVVDKESYGGQHYCRLKDLPFFLAFLAPVVSIIFFNTIIFGIIMYKLSVRPPARSADKDRGREGILQLRRAFGILILVGLTWMFGFFAISSMRLVFTYLFAVLNCLQGFSIFMFYCVTQKNVRDCWRALLRCDLQSLNKKTMYTESYDPKTKTHLDTMRPRAKTEPAKGNTLQKDKLRPRMNTADVKLPIRDVYKPSEMSSDNPNYVNSEEDESAVKLLTHVTVTIEPPRDYQNALGSQCIDLDQSHEEIELMSRPESRSGSIRSHDTSRSRDPSKHGSRGTINSNQSTPKLFRIPRFNGGNSIGALSVENKSPVKINLKRTASHAPEAPKMYTPMCLRRTKSASSLGKDNRFSGKSLISFSSTSSESLSTDSQSAPRRSRLLRISDLDPDKYGELIISPQRGSVRGIVGHVETSVDTYDDIIEHEKKRSISLPPGAYSLHSSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU05</accession>
    <name>A0A6P8HU05_ACTTE</name>
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        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 9-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">LOC116295126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_031702863.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="aten:116295126"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SDS22/Internalin_LRR"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1666"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031558723.1"/>
        </source>
    </evidence>
    <sequence length="1712" mass="195052" checksum="9D2A9727433210E6" modified="2020-12-02" version="1">MKGLMTGSSKASDEDEETVRELVKPAKKSRSPRNTKGNNQIKELCTSNGINYEKLQKGSAKAVKKLEMFFSGFPKICGMELFPVLQSLCLIGQEIEVLENLETLINLTELFVCECAVKKITGLEKCVNLKKLFLYDNEIPRIENLSNLTKLTTLWLNNNNITAIEGLENLTLLTNLNLASNRISAIGNSLIHNTSLETFDLSANNLGSFKDLTNLTKLKNLTSLSLKNPVYGPNPVSLLCNYSTHLLFHLPNLKRLDTYDVESKQLKELAKTTVMKKKMYYNMRIKTLQRNTADLQHKLTNEKYNLQMFANTRIRALYSCIKEIEREQEETHLAPPKELRNQSSDEEGEKEKTKEEDNPDELTKKFEIKKEALKTRIKKWDKQCQEIESSYRESWEQVQLVSDMTIQRLLVELDTGGNVRFEDGKPTDIWYKSCHDLVTSRFCAGDYLNYGVTGIKVHRITRVHNRILRARFDEVLYQTLAKSHIVEITKGRSHKKLLEYLFFMWNPDAFDEANEPVTVLEKGFRKSTEYEKAGFDGGVPLSNSVGICDQSRIQKCTAKSKEKGIANPFPFRHGQLIISKTFVGRAVSANTGETRVTKGRYPYADSVFRLRTHEASKTEIAKPVKSCDCSSRQCEWFVFDHEMVLPEYVVDFEYLTRHKSKSPYIHYIGDTVHKSTSSDSGQNENYVDVDVLNMEPKSKPRPRLIGLTEEILLSHCNVQSLEHITVLNLHGNGLNRLKHLNSIPLLKKLILSFNELTKLDDINHMSFLEHLDVSFNKVTTLEGLKGCTRLRYLDISWNKLKFIREELGIMRKHIATLVTLDTRNNPWQKPETLRTRALGRLRNLEVLDDIPVTDDEVALALRMAAASRISTFAILAHSRTDQVKPRSLSIVPTAQTILATSIQKPARPMDDDNQWMVKVTTLNLDNMRLGKISNLEKLVNLRWASFNDNDLTKIEGFEHCSMLEELSLEGNCISKFEGLVRNPKIQWLNLRNNNLVNLDTGMLERLPELKYLSIENNLITSLRGLQHLVNLQELYIGNNEIANTREIFTLKTISTLVILDLFGNPLVENTINYRLFVVYHLTTLKALDGLAVEPSEGGVAKDTFGGRMTTDFIAERLGHSNFAELRELDFPSCSLRTVDLGSGEQFLNLRSVNLEHNSLTSFGGLINLVHLKPTITKQREVRLSIMEEQEAQAELSENDKVDNGSPEDNELDEPEMKTLEAISIQDEAYFNSLKTQKSDYTFKIMCVGDYTGFGKKGGFVADYIHERPLSFYHKPTIGVDFYIHFLKWKDTVKKKEFSVKLQFWDVAEHERFLNMTGIYCRNCAGALVFWGPKSPSRLSSTLKWSQKIQEANTGDRPMVLIVENIPTSRRGKPIEWIGPGKMFESREALDRFCVKNGFLGCYNGISNMATLQLSRLPNLKALFLQGNEIAKVEGLQGLQELRELVLDRNKIKGLSEHSFINQWNLVELHMEENRIRDLNHVESLQNLQRLYVGMNRIQDFTELEKLESLSNLIELSVINNAVTRRLLHRPMLVFRMPSLLCIDGIPVSPEERTKAEIYFLEQQSMQGNSMTIESALPGIVSARQSQAPLRVTTMHLSNTERNWSGKTRQDNINSVSSNGDSRDSNKGQRRVTNQKGPSSGPVQTTNPYPSADSYSHVNIDRQLRSHSNSNVTNAQSSSRQPGGSNSISYIPHGFTYPNYPYTNDGDARTRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HU53</accession>
    <name>A0A6P8HU53_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116293001</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116293001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031556240.1">
        <property type="nucleotide sequence ID" value="XM_031700380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HU53"/>
    <dbReference type="GeneID" id="116293001"/>
    <dbReference type="KEGG" id="aten:116293001"/>
    <dbReference type="InParanoid" id="A0A6P8HU53"/>
    <dbReference type="OrthoDB" id="5976961at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF335">
        <property type="entry name" value="EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="162"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="350"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031556240.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51270" checksum="CA948784BDE74B28" modified="2020-12-02" version="1">MNKRRCLEQSLVGKNNLSIPDSSYTASSYHKNSTIPGDVRYAPYNAKLNGSYGWGARDNNNPDDYLQIDLGTTRVVTALATQGNGFSDEWVSKYKIHHSNNLTKWTSYAENHFLKIFEGNTDSNGVKRHDLSQNPITARYIRFVPVTYNGHKTMRVDISVIYQEVPVVSAIPQQRSIQLSWIIKQCNLTGPITGFVIKNGSKDLHVSGSDRQYALLGLKPHTEYDVRLLAKTQRVNGSWSETTKIKTKEDAPSAPVNVTGALIPAQGSFGPRAVITWERPRYLHGIIRKYTIVYYYNEETFNDKTVTISGSADLNYSINVTKNGILSYKISATTVKEGPYADGKDIEYGCPEQSLVGKEKNLKLSDSSYTASSYYRRPSFPGDVRYAPYNAKLNGSHGWAARYNNNPDDYLQINLGTPRVITAVATQGSGRTANREWVTKYKLYLAPNNITRWYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HUG9</accession>
    <name>A0A6P8HUG9_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribonucleases P/MRP protein subunit POP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC116296206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Tentacle</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_031560059.1">
        <property type="nucleotide sequence ID" value="XM_031704199.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HUG9">
        <property type="interactions" value="1803"/>
    </dbReference>
    <dbReference type="GeneID" id="116296206"/>
    <dbReference type="KEGG" id="aten:116296206"/>
    <dbReference type="InParanoid" id="A0A6P8HUG9"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="135"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="559"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="809"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="867"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_031560059.1"/>
        </source>
    </evidence>
    <sequence length="931" mass="104285" checksum="F5212DB924D6F09B" modified="2020-12-02" version="1">MASEEKVHVNKTNRKRKHGTLSAGPSAKSSPXSSSTVNAQAPRGINVVEFAEARALELHNMVEGMAMADRTGKKRLFQSLPKHMRRRAMSYNVKRMPVRLREQAKKEMEKNKLDAKTTKKSRRQRRKAKELLEDYNRRKKQNIWLETHIWHAKRMKMVNSWGYRLAEHPSDKGFRAAHRAAASNCLLQDISYYGCIEIKGNRKNILSAMGLLTRTELGPTIGSLDCMNTGKEGHVVLYHKDCYPFGAVGPVSFLWRQDRHQNDGDIFIDDGSTSQSSQLWIWAHPACFAVVFQAIQEACQSVTSTVVVQDCASQNDNPSTESQEMKTSPTTKQGQHINISSLRFDLARFRLTGPLSHSLLVNMLELPGENKPVQREKCLMHDESFLIEKDEQNAINTTGNETTKCGCTINSDTQVGAYESALSSEAFWERIKSSSTSSILPAYTVIGLTVVDPRLGMPGIRTSIDSFLTEQHNRKGDIPPSRSSSDMLFTKCPPHIATSSIWDVNTRQNVKETKITEQNLNQMRSELLVPGSRLDLGDKTSHIPVLLVQQPGSNGYAGGWDIILPAGWAMAFWMALVYRGARVGGLRESRNCSLECEEPYFPRDVPDTCSGKQYNRDVQTEEENRYNRYPPAKRPNYTKLGFLSPFFIPWSQLVEEWSLEVLNNEAVPDARLDLHDLSLGRQVIDNVSPXGRQGIDNTSSVPQQDIKNVTFGSQEIHHLAPLDHGQPKSETSQTGEEIDIDMNMESKPTRHNSNLTFFVLRDLSQLRLLRKIITSLRSKTNRCKPSDTSHSKLDIRPLVDTMTSNPRGLVGVSLRMLNKGYPLPNATVSIPSVVDIQALEQDKAFGGPVEPLHKGSTNVAEKNMMIGRCSRKVIGFVTSGQYSLSRGFGVGIAYCALPGLVELLTTRDQAVVLVRNTKSLQYRMALIEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HWU8</accession>
    <name>A0A6P8HWU8_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC116296048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_031559863.1">
        <property type="nucleotide sequence ID" value="XM_031704003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HWU8"/>
    <dbReference type="GeneID" id="116296048"/>
    <dbReference type="KEGG" id="aten:116296048"/>
    <dbReference type="InParanoid" id="A0A6P8HWU8"/>
    <dbReference type="OrthoDB" id="5973784at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559863.1"/>
        </source>
    </evidence>
    <sequence length="744" mass="85314" checksum="D9A73CFEE40AA82C" modified="2020-12-02" version="1">MEAETSQEVVKISRAKETGEITQLDKVEDPEKEVMVTCVKKRPLLSTGECPVCGERRKHLRAHLATNKPGHGWSSEKYEQWLFQKQSEQRKDRHRIRACPAKKCTWSGVKLERHLNVHHDIDIGSEKMARLKAKSKIISKKEKMITTTKDTPNNTQDDQSSKSKKQEVDGKKPLSKFKMALLKLAKDVETKKKCPLALDSESEEQEGSEWDERDENDESEDEISEDNKDSEENEACKEQEMDESIGDDVSDDNDNVQGKEANLGPYGPNSMPTNIFESLVRGWNIYLATPDGTEKTPAMIRQMCQHVVTIAKAVDPNVRDLGVFLDKDRLYKRFFKRQIELRKQEKSQGLCSKTLSCYSSSLERFLTYAIKSMKRSLSSDKREALEELKDTQRNWRESWGKTIAKQRADQEWKAQNVLPTVQEIRSINSSSHVKEMREMIMHTSNYSLTPEDAVNVRNYLIFLINTENANRAGPCAKWTIHISNQKTTKTLGGLILNFSNDLRLMIIRYIKYFRQLLIKDGSETDAMFLNSTGSPYTNSHVHHALKQFVAKTGCLREESVSGFSSSMIRHCIVTNTRGLSSPEKNKLASKMGHSRATADRHYNLINKMQAASDAHDTITTLMDGKLEEKALELEAEDEKDEPEVDVKSFQETEKGSDVIPPSENADVGRSSICYKRRQWSIADTKKIEDVCRNEITSVKVPTRDMIIRKLINNKETFEITQREGTERAYQKVKHMRRNYQIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HX21</accession>
    <name>A0A6P8HX21_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC116296125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031559943.1">
        <property type="nucleotide sequence ID" value="XM_031704083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116296125"/>
    <dbReference type="KEGG" id="aten:116296125"/>
    <dbReference type="InParanoid" id="A0A6P8HX21"/>
    <dbReference type="OrthoDB" id="5982078at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="596"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="778"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="895"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_031559943.1"/>
        </source>
    </evidence>
    <sequence length="1792" mass="209571" checksum="4DC38862E05F7FCA" modified="2020-12-02" version="1">MNPDNVLRREDTEIDLIQRRFNEALCDKDXEIASLRETMKNIVSSMRYGNTFSDADLSIVDYFEMRSELEKYRKLLKESERGEKELLASLKECKSALREKEEEARRLSEVFNRHKDCVDLTTVEKLRKCLEAKNDEEKKIIKMNEFLQQAIKEKDQKIAELRLSLWEAQSYCETRSARLGKLNDDTILSKDREIDFLREEKKRLEQDIEGIRKSSAETLGLKEAEIERMRRAATNFQDAVKLEDTTIWKLQTALELKEKELFSVEKSRKLEIEAKTEEFERTRKELEERLCLIKTELQNVKDNADLALRDKQLHVEDLIRXIDEENRNSSAEILEKDKEIENLKEKVTEMEEVLRSKEKKIDETKKFLSNAEDSVKKLQEELSLKLKHHEMEIVHRNSIMESLRKAKEISEQTLSNNIHMLQQKLNEANKEIILHGENEIKVEKLSRSNKDKELELVELTKAVNELEEENKTLKERVHFLNSNLEKKVSTLETTVDYVEVLKKEKRNMEEEILCLKRKLSDSRIKNNKYEMALDNLEISSEETEDEGIRIVNDRGIGKTSFLHGKESESELYLRDESFATNNDERFQVLGLDNEDVQELKKELNVLKLRCKEKEESSYLMKTMLEESEKMIRNLESRIQKLSNAVEDEKDAHKKTAKDMQELLSMNEILVDEVQKFETLQDQQIEEVRGFYDLLDEEEEGLTNGSTPKSLRDRTKPSFPKTTKSKKEFEDIFWRKKSEKDGADSKEVLMSKMKKTLSEKTKWNSKRFQDMNLLINQTLAKKNLELKALKKKNEQLQELLENKELEISSGKELIMSRQKYKRQMEEFKEYKAKAFEEFDKEKKELXQSMMKEIASKEKEIQNLVDCSKETLEKKEEIIAGFKQFIQETALRNKNSLSEKEDIIISIRKEIEALKDEKEKLQNTLNAVVKKCTGLENKVKNSDGIRIKVEEESRNLVGKLESKIRMRDELNMRLKSDINNERKMRGKMEIEIEKLREMLKNEELLSQEGEKILRHVTDEKEQESRILREKEEQCNNLEGALTEKQNMVHLLKQEKKDLIKENERLKNNDGKLTKKIDNKQEKIEELKVVITELKEVVVKFKQKVSKTEQLNLVLRERLDQKSKENIEKEQEIKNLRILNDKIRDEQHVSGNKLSELETQIKNLEDKLQDLTKALAESQTMNSGLKKSLESSKALSEKLEIKVVAFEEELRKKEQEISVLELAIEGLKEAKQSLILQKDEIGRIKDEEIESLRKELECSRIYLNQGEEIINNVVREKDNLIQELGKTIEMHKNAALTMESYYKSLQHDKETLVEKTNALENELSERNKKNIELNSALQAAEMSIRFLSENMDKLNSVKQVLEKKQEENALLRSKVKEHEELNDKEMQNNRRKMRKNEEEFLKLCEDYQNLENVLRQTEKDLKKAESGNNDIKQDNQELREIVDNTNQMNKEIEKAMLKYKEDAERMENMLSQLKTDNDFLQEFAKDTEKIKLKLNAVEVLCVVLVVEMVVVALTQSQLETRVQASEKEIKELRVMLEERTRDVSLIKVDKNNLEMQKREADMKIMELTNSLKNETAFQQIVSQRNQELELEVRQIHRDKTLGLLSPRLPNNPQPSRDLEVVYPDLAAERSLQQKVDNIAVDKIRTLHSKKAQLEIELEKERHERVKDHAELARLKAKLAVYRSCILVSTPSPRVGHTKPSPTEPPVVNQVXCTIASFDESFGWISDCCNHPITTKTSATAGQNCVTRIDINSPATISIDSSFTGAICSSLSRITVMVRRHANSPASSPTGYKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HXN1</accession>
    <name>A0A6P8HXN1_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC116296258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC116296258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031560116.1">
        <property type="nucleotide sequence ID" value="XM_031704256.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P8HXN1">
        <property type="interactions" value="1737"/>
    </dbReference>
    <dbReference type="GeneID" id="116296258"/>
    <dbReference type="KEGG" id="aten:116296258"/>
    <dbReference type="InParanoid" id="A0A6P8HXN1"/>
    <dbReference type="OrthoDB" id="6256369at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040171">
        <property type="entry name" value="USBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019536">
        <property type="entry name" value="USHBP1_PDZ-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347">
        <property type="entry name" value="COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347:SF6">
        <property type="entry name" value="FI17904P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10506">
        <property type="entry name" value="USHBP1_PDZ-bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Harmonin-binding protein USHBP1 PDZ-binding" evidence="3">
        <location>
            <begin position="690"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Harmonin-binding protein USHBP1 PDZ-binding" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="966"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="408"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="979"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_031560116.1"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125350" checksum="F9B00936FD8F035B" modified="2020-12-02" version="1">MSDFERHENGVACLSSTSSKSTESLEENIRKILNVVDGKGRVLVDSNDMAEAAQQLTVDANGFHEFLSQIQYENNPKTSDKMASGQFASPTRRSNSCPEDLAKQSDYKQRENENKGSDKGPIRETWEMDSGTHDLGNYEPALQQLMSAATGKGQSRSSNFLELANTLHLAALASLKNEIVDVSGKLQQVTEERDSIKTNIEFTNEERKELIRDYEERLLSQAQQSEEQITELQSVIAELNKKLANASANKIEELEEVESQTSEHGSRSSESLESLEDEDEVDDELSKVVGDLEFAIEREKPEPKDNKKDKEPIKVTVKVTDDKSNNVIEVSKAVGSRASTDNKSQECNQLMEKARLLREQCVELEKKKQVLERQLQQASLREYVARKKSSSIGSEGQSQDAQTPCNECAGLRTKLNQTTQELETSRQEISSFREERDKLRKRILEMQDHLKALHQKTINFETRSRSSSFHEPGSKSPRQPRANPPQPGDPRGPHTGSRSFPRQTSYSSNASDVSSRDGFLAASPRTARRSSIENLNNSMSKSRSPSTPRRSVTLPGNYTRRASGSSMSGQGLPDSPTMTPRGSVQSVASSQSFWRGAGTSDLGSSQGSSSQEITVIARPVDDTMDTRTSGDHCIRSLSQLPEFANGRLPNELLRSLRSCRNLQDVYKVLFSYCDDQADKKLKEYELEIERLNCTVEHLQSQINVLCLSLEESRENAEKMCVLMGKYESNSTASQLSLTFCDKVIETYEVLLQLSESEQSCLLANCKAAGVKTGLNSSYRLLYPENXIKDDQSDDVDACLVRRRTAETEARSLLQKLDKDLEEQYIKEQPWESVSSRSRTSSGSSNENMEFTREEETRLKSYIQQLKSERLTVGSTVLELQGVHDVPEPQKIDSLDPKLDLENAVLMQELMALKEEKAELKAKNYLIEKEKKALELKINSREAHEQAYLLQIEQLKSEIREELKKRRRIEKERDAGNKDGNLSSGNQSSSGSGSGNLSDIRISDDDLPTDLHEAAIREKKLRARIKELMEALESLSKNSETRHTQTAEYVSDLKRANGALVAAYEKAKKKHAARLRKLEQQMMCVVERHDAQVRTLKERISLLEEEVSSRQNETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HYV5</accession>
    <name>A0A6P8HYV5_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450 3A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC116296667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031560583.1">
        <property type="nucleotide sequence ID" value="XM_031704723.1"/>
    </dbReference>
    <dbReference type="KEGG" id="aten:116296667"/>
    <dbReference type="InParanoid" id="A0A6P8HYV5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="13">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_031560583.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="55681" checksum="9DE069C972B15377" modified="2020-12-02" version="1">MWLVIAVVVVLLALIYWNGVKDFSLLAEIPLDGPKPWPYVGNILDVFKYGGLHKTYMAYFKEYGRVYKMAIGRKPTIVVNDPEMVKQITVKEFSKFRNRTLPIQLNPPLSSGVFFARDATWKRIRTTLNPTFSAAKLRQVVPLIETSCDKLAKKMHKFAETGESXNCTKLFSLFALDVIMKAAFRYDVDIQNDAEATFIKRAKEALKTPIWIRFFSMFPFNKYLSKLTNPIGHLEYFAGIARSMIESRKSVGHVETGRRDLLQLMLDAHEEELAEGLTRLSDEELAAQSVIFLLGGFETTGTTLSCAAHVLATRPDIQEKLIQEIDKARENRESESLYDFVQKIDYLDQFISEVLRIYSPAFNLIRECNEEVVIAGVRFPKGIDVTIPNYSLHRDPDSWEKPEEFNPGHFTAEAKAKRHPYSYLPFGIGPRQCIGMRFAMNEIKIGLFNVLEKFKFEKAPETVEIEGRAVLLMRPKDDITLRIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8HZH9</accession>
    <name>A0A6P8HZH9_ACTTE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC116294531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Tentacle</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_031558017.1">
        <property type="nucleotide sequence ID" value="XM_031702157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P8HZH9"/>
    <dbReference type="FunCoup" id="A0A6P8HZH9">
        <property type="interactions" value="1713"/>
    </dbReference>
    <dbReference type="GeneID" id="116294531"/>
    <dbReference type="KEGG" id="aten:116294531"/>
    <dbReference type="InParanoid" id="A0A6P8HZH9"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_031558017.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13579" checksum="E44AB27414A86624" modified="2020-12-02" version="1">MASHSQGIQQLLAAEKRAAELVSDAKKRKTKRLKQAKEEAVEEITSYRAERENQFQEYQKEHMGSKDDFQVKIDENTKVKLDVMTNDVNQNKDKVIKRILSLVYDISPELHENYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P8I1N3</accession>
    <name>A0A6P8I1N3_ACTTE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein K02A2.6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC116297340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Actinia tenebrosa</name>
        <name type="common">Australian red waratah sea anemone</name>
        <dbReference type="NCBI Taxonomy" id="6105"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Cnidaria</taxon>
            <taxon>Anthozoa</taxon>
            <taxon>Hexacorallia</taxon>
            <taxon>Actiniaria</taxon>
            <taxon>Actiniidae</taxon>
            <taxon>Actinia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Tentacle</tissue>
        </source>
    </reference>
    <dbReference type="RefSeq" id="XP_031561421.1">
        <property type="nucleotide sequence ID" value="XM_031705561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="116297340"/>
    <dbReference type="KEGG" id="aten:116297340"/>
    <dbReference type="InParanoid" id="A0A6P8I1N3"/>
    <dbReference type="OrthoDB" id="5986177at2759"/>
    <dbReference type="Proteomes" id="UP000515163">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000004">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="200"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000515163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_031561421.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="44012" checksum="95C5218B76E4FBFB" modified="2020-12-02" version="1">MRLQLQKYSLALEYKXGPKMYISDTLSRAXLPNMQSTRTETPYYQIFQIQEEQKLCEELENISHXEALFVTDSRLNAXKYETAKDTSIQTLMXVIKEGWPDSKTDVPLCIREYWAYRDELTTQNGLAYRGTRIVIPTTMRTEMVKRAHASHLGIQYTINTARDIMYWPXMTADLTEAVNSCTTCQTRPTPQKEPMMXHPIPQLPWQAVASDCFELEGQHSVILVDLYSDCIEVAKLPNMSTTSLINQIKPIFATHGSPEVLITDNGTNYVSKEFKTFXRTWDITHVTSSPHHQKSNGKAEFAVKIMKNLIKRAQKERQDXWKAMLEWRNSSTPGTTSSPAQRLMSRRTRSFLPCIQPQRVQTRSSNQCHRSSCTEEKTSQVVL</sequ
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